organism	gene	review_path	gene_symbol	uniprot_id	taxon_id	taxon_label	annotation_index	reactome_id	reactome_title	reactome_cached	reactome_path	reactome_display_name	reactome_species	term_id	term_label	evidence_type	qualifier	aspect	negated	isoform	review_action	review_summary
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	20	R-DME-110475	DAkt1-mediated phosphorylation inactivates DFOXO	yes	reactome/R-DME-110475.md	DAkt1-mediated phosphorylation inactivates DFOXO	Drosophila melanogaster	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Akt1 is a serine/threonine protein kinase.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	21	R-DME-169828	Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex	yes	reactome/R-DME-169828.md	Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex	Drosophila melanogaster	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Akt1 is a serine/threonine protein kinase.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	77	R-DME-110463	Increased PIP3 levels recruit DAkt1 to the membrane	yes	reactome/R-DME-110463.md	Increased PIP3 levels recruit DAkt1 to the membrane	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 localizes to the cytosol/cytoplasm.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	78	R-DME-110468	Activation of DAkt1 by DPDK1	yes	reactome/R-DME-110468.md	Activation of DAkt1 by DPDK1	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 localizes to the cytosol/cytoplasm.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	79	R-DME-110475	DAkt1-mediated phosphorylation inactivates DFOXO	yes	reactome/R-DME-110475.md	DAkt1-mediated phosphorylation inactivates DFOXO	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 localizes to the cytosol/cytoplasm.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	80	R-DME-169828	Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex	yes	reactome/R-DME-169828.md	Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 localizes to the cytosol/cytoplasm.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	81	R-DME-110463	Increased PIP3 levels recruit DAkt1 to the membrane	yes	reactome/R-DME-110463.md	Increased PIP3 levels recruit DAkt1 to the membrane	Drosophila melanogaster	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 can localize to the plasma membrane upon activation.
DROME	Akt1	genes/DROME/Akt1/Akt1-ai-review.yaml	Akt1	Q8INB9	NCBITaxon:7227	Drosophila melanogaster	82	R-DME-110468	Activation of DAkt1 by DPDK1	yes	reactome/R-DME-110468.md	Activation of DAkt1 by DPDK1	Drosophila melanogaster	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Akt1 can localize to the plasma membrane upon activation.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	31	R-DME-432371	CRY is activated by light and binds to phosphorylated nuclear TIM	yes	reactome/R-DME-432371.md	CRY is activated by light and binds to phosphorylated nuclear TIM	Drosophila melanogaster	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places CRY in nucleoplasm during circadian signaling.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	32	R-DME-432378	Nuclear JET binds CRY, facilitating its ubiquitination	yes	reactome/R-DME-432378.md	Nuclear JET binds CRY, facilitating its ubiquitination	Drosophila melanogaster	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places CRY in nucleoplasm during clock-regulatory steps.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	33	R-DME-432424	JET binds phosphorylated nuclear TIM, facilitating its ubiquitination	yes	reactome/R-DME-432424.md	JET binds phosphorylated nuclear TIM, facilitating its ubiquitination	Drosophila melanogaster	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotates CRY in nucleoplasm for TIM-related steps.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	34	R-DME-432652	Nuclear CRY is degraded by the 26S proteasome	yes	reactome/R-DME-432652.md	Nuclear CRY is degraded by the 26S proteasome	Drosophila melanogaster	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to nucleoplasm, consistent with light-induced nuclear localization.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	35	R-DME-432401	JET binds cytosolic TIM, facilitating its ubiquitination	yes	reactome/R-DME-432401.md	JET binds cytosolic TIM, facilitating its ubiquitination	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to cytosol in light-input pathway steps.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	36	R-DME-432426	CRY is activated by light and binds to cytosolic TIM	yes	reactome/R-DME-432426.md	CRY is activated by light and binds to cytosolic TIM	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to cytosol during TIM-related interactions.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	37	R-DME-432428	Cytosolic CRY is degraded by the 26S proteasome	yes	reactome/R-DME-432428.md	Cytosolic CRY is degraded by the 26S proteasome	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to cytosol during degradation steps.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	38	R-DME-432593	Cytosolic JET binds to CRY, facilitating its ubiquitination	yes	reactome/R-DME-432593.md	Cytosolic JET binds to CRY, facilitating its ubiquitination	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to cytosol in ubiquitination steps.
DROME	CRY	genes/DROME/CRY/CRY-ai-review.yaml	CRY	O77059	NCBITaxon:7227	Drosophila melanogaster	39	R-DME-881988	CRY is phosphorylated by SGG	yes	reactome/R-DME-881988.md	CRY is phosphorylated by SGG	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns CRY to cytosol for phosphorylation steps.
DROME	Pdk1	genes/DROME/Pdk1/Pdk1-ai-review.yaml	Pdk1	Q9W0V1	NCBITaxon:7227	Drosophila melanogaster	17	R-DME-110468	Activation of DAkt1 by DPDK1	yes	reactome/R-DME-110468.md	Activation of DAkt1 by DPDK1	Drosophila melanogaster	GO:0004676	3-phosphoinositide-dependent protein kinase activity	TAS	enables	MF	false		ACCEPT	PDK1 has 3-phosphoinositide-dependent protein kinase activity.
DROME	Pdk1	genes/DROME/Pdk1/Pdk1-ai-review.yaml	Pdk1	Q9W0V1	NCBITaxon:7227	Drosophila melanogaster	18	R-DME-169827	DPDK1 phosphorylates and activates DS6K	yes	reactome/R-DME-169827.md	DPDK1 phosphorylates and activates DS6K	Drosophila melanogaster	GO:0004676	3-phosphoinositide-dependent protein kinase activity	TAS	enables	MF	false		ACCEPT	PDK1 has 3-phosphoinositide-dependent protein kinase activity.
DROME	Pdk1	genes/DROME/Pdk1/Pdk1-ai-review.yaml	Pdk1	Q9W0V1	NCBITaxon:7227	Drosophila melanogaster	25	R-DME-110468	Activation of DAkt1 by DPDK1	yes	reactome/R-DME-110468.md	Activation of DAkt1 by DPDK1	Drosophila melanogaster	GO:0045793	positive regulation of cell size	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	PDK1 promotes cell size via insulin signaling and S6K/Akt activation.
DROME	Pdk1	genes/DROME/Pdk1/Pdk1-ai-review.yaml	Pdk1	Q9W0V1	NCBITaxon:7227	Drosophila melanogaster	40	R-DME-110468	Activation of DAkt1 by DPDK1	yes	reactome/R-DME-110468.md	Activation of DAkt1 by DPDK1	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	PDK1 localizes to the cytosol.
DROME	Pdk1	genes/DROME/Pdk1/Pdk1-ai-review.yaml	Pdk1	Q9W0V1	NCBITaxon:7227	Drosophila melanogaster	41	R-DME-169827	DPDK1 phosphorylates and activates DS6K	yes	reactome/R-DME-169827.md	DPDK1 phosphorylates and activates DS6K	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	PDK1 localizes to the cytosol.
DROME	krz	genes/DROME/krz/krz-ai-review.yaml	krz	Q9V393	NCBITaxon:7227	Drosophila melanogaster	19	R-DME-2071846	Deltex recruits Kurtz arrestin to Notch	yes	reactome/R-DME-2071846.md	Deltex recruits Kurtz arrestin to Notch	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) cytosol localization for the ""Deltex recruits Kurtz arrestin to Notch"" step, consistent with the cytoplasmic/cytosolic localization of Krz."
DROME	krz	genes/DROME/krz/krz-ai-review.yaml	krz	Q9V393	NCBITaxon:7227	Drosophila melanogaster	20	R-NUL-2071858	Kurtz promotes ubiquitination of Notch	yes	reactome/R-NUL-2071858.md	Kurtz promotes ubiquitination of Notch	Drosophila melanogaster	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) cytosol localization for the ""Kurtz promotes ubiquitination of Notch"" step, consistent with the cytoplasmic/cytosolic localization of Krz."
KLEPN	rmtD	genes/KLEPN/rmtD/rmtD-ai-review.yaml	rmtD	B0F9V0	NCBITaxon:573	Klebsiella pneumoniae	3	R-HSA-9913143	Antimicrobial resistance	yes	reactome/R-HSA-9913143.md	Antimicrobial resistance	Homo sapiens	GO:0046677	response to antibiotic	TAS	involved_in	BP	false		ACCEPT	The gene product is an antimicrobial-resistance determinant, so the antibiotic-response annotation is retained.
KLEPN	rmtD	genes/KLEPN/rmtD/rmtD-ai-review.yaml	rmtD	B0F9V0	NCBITaxon:573	Klebsiella pneumoniae	4	R-HSA-9911509	RMTases methylate 16S ribosomal RNA	yes	reactome/R-HSA-9911509.md	RMTases methylate 16S ribosomal RNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cellular location is compatible with the encoded AMR enzyme and is retained.
KLEPN	rmtD	genes/KLEPN/rmtD/rmtD-ai-review.yaml	rmtD	B0F9V0	NCBITaxon:573	Klebsiella pneumoniae	5	R-HSA-9911509	RMTases methylate 16S ribosomal RNA	yes	reactome/R-HSA-9911509.md	RMTases methylate 16S ribosomal RNA	Homo sapiens	GO:0008649	rRNA methyltransferase activity	TAS	enables	MF	false		MODIFY	The existing MF term is directionally correct but less informative than the family-specific AMR activity rRNA (guanine-N7-)-methyltransferase activity.
KLEPN	rmtF	genes/KLEPN/rmtF/rmtF-ai-review.yaml	rmtF	I1YZZ5	NCBITaxon:573	Klebsiella pneumoniae	3	R-HSA-9913143	Antimicrobial resistance	yes	reactome/R-HSA-9913143.md	Antimicrobial resistance	Homo sapiens	GO:0046677	response to antibiotic	TAS	involved_in	BP	false		ACCEPT	The gene product is an antimicrobial-resistance determinant, so the antibiotic-response annotation is retained.
KLEPN	rmtF	genes/KLEPN/rmtF/rmtF-ai-review.yaml	rmtF	I1YZZ5	NCBITaxon:573	Klebsiella pneumoniae	4	R-HSA-9911509	RMTases methylate 16S ribosomal RNA	yes	reactome/R-HSA-9911509.md	RMTases methylate 16S ribosomal RNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cellular location is compatible with the encoded AMR enzyme and is retained.
KLEPN	rmtF	genes/KLEPN/rmtF/rmtF-ai-review.yaml	rmtF	I1YZZ5	NCBITaxon:573	Klebsiella pneumoniae	5	R-HSA-9911509	RMTases methylate 16S ribosomal RNA	yes	reactome/R-HSA-9911509.md	RMTases methylate 16S ribosomal RNA	Homo sapiens	GO:0008649	rRNA methyltransferase activity	TAS	enables	MF	false		MODIFY	The existing MF term is directionally correct but less informative than the family-specific AMR activity rRNA (guanine-N7-)-methyltransferase activity.
SCHPO	chk1	genes/SCHPO/chk1/chk1-ai-review.yaml	chk1	P34208	NCBITaxon:284812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	14	R-SPO-75040	Phosphorylation of Wee1 kinase by Chk1	yes	reactome/R-SPO-75040.md	Phosphorylation of Wee1 kinase by Chk1	Schizosaccharomyces pombe	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation (Phosphorylation of Wee1 kinase by Chk1) supporting Chk1's Ser/Thr kinase activity. Correct core molecular function.
SCHPO	chk1	genes/SCHPO/chk1/chk1-ai-review.yaml	chk1	P34208	NCBITaxon:284812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39	R-SPO-75040	Phosphorylation of Wee1 kinase by Chk1	yes	reactome/R-SPO-75040.md	Phosphorylation of Wee1 kinase by Chk1	Schizosaccharomyces pombe	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome) consistent with Chk1's nuclear function in phosphorylating Wee1/Cdc25. Correct.
SCHPO	wee1	genes/SCHPO/wee1/wee1-ai-review.yaml	wee1	P07527	NCBITaxon:284812	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36	R-SPO-75040	Phosphorylation of Wee1 kinase by Chk1	yes	reactome/R-SPO-75040.md	Phosphorylation of Wee1 kinase by Chk1	Schizosaccharomyces pombe	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization asserted by Reactome (phosphorylation of Wee1 by Chk1 event). Consistent with the experimentally established nuclear localization; nucleoplasm is a finer-grained subcompartment of the nucleus.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	7	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places A1BG in the secretory-granule lumen and its exocytosis reaction. Retain this curated contextual location; CRISP3 localization is not independent evidence for A1BG localization.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	8	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places A1BG in ficolin-1-rich granules and their exocytosis reaction. Retain the contextual granule location. Ficolin-rich granules are distinguished from specific granules in the cached reaction summary; no CRISP3-based localization inference is needed.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	9	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the Reactome-curated platelet alpha-granule lumen location as a contextual site of A1BG storage/release. The reaction does not establish that A1BG performs the exocytosis machinery function.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	10	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places the released A1BG in the extracellular region following platelet alpha-granule exocytosis. Correct core localisation for a secreted plasma glycoprotein.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	11	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome secretory-granule exocytosis reaction placing A1BG in the extracellular region. Correct core localisation.
human	A1BG	genes/human/A1BG/A1BG-ai-review.yaml	A1BG	P04217	NCBITaxon:9606	Homo sapiens	12	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome ficolin-rich granule exocytosis reaction placing A1BG in the extracellular region. Correct core localisation.
human	A1CF	genes/human/A1CF/A1CF-ai-review.yaml	A1CF	Q9NQ94	NCBITaxon:9606	Homo sapiens	27	R-HSA-77608	Binding of A1CF to stem-looped RNA	yes	reactome/R-HSA-77608.md	Binding of A1CF to stem-looped RNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places A1CF-RNA binding in the nucleus, consistent with nucleoplasmic editosome assembly.
human	A1CF	genes/human/A1CF/A1CF-ai-review.yaml	A1CF	Q9NQ94	NCBITaxon:9606	Homo sapiens	28	R-HSA-77609	Binding of APOBEC-1 to form editosome	yes	reactome/R-HSA-77609.md	Binding of APOBEC-1 to form editosome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome models APOBEC1 joining the A1CF-RNA complex in the nucleoplasm.
human	A1CF	genes/human/A1CF/A1CF-ai-review.yaml	A1CF	Q9NQ94	NCBITaxon:9606	Homo sapiens	29	R-HSA-83677	C4 deamination of cytidine	yes	reactome/R-HSA-83677.md	C4 deamination of cytidine	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome assigns A1CF to a nucleoplasmic deamination reaction, although its cached prose is sparse.
human	A2M	genes/human/A2M/A2M-ai-review.yaml	A2M	P01023	NCBITaxon:9606	Homo sapiens	19	R-HSA-1454781	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin	yes	reactome/R-HSA-1454781.md	MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places A2M in the extracellular region while it binds and traps extracellular matrix metalloproteinases.
human	A2M	genes/human/A2M/A2M-ai-review.yaml	A2M	P01023	NCBITaxon:9606	Homo sapiens	20	R-HSA-158340	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin	yes	reactome/R-HSA-158340.md	kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places A2M in the extracellular region during inactivation of plasma kallikrein.
human	A2M	genes/human/A2M/A2M-ai-review.yaml	A2M	P01023	NCBITaxon:9606	Homo sapiens	21	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places platelet-stored A2M in the extracellular region following alpha-granule exocytosis.
human	A2M	genes/human/A2M/A2M-ai-review.yaml	A2M	P01023	NCBITaxon:9606	Homo sapiens	22	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome identifies A2M as cargo within the platelet alpha-granule lumen before regulated exocytosis.
human	A4GALT	genes/human/A4GALT/A4GALT-ai-review.yaml	A4GALT	Q9NPC4	NCBITaxon:9606	Homo sapiens	6	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS annotation to glycosphingolipid biosynthetic process, via the ""Glycosphingolipid biosynthesis"" pathway. Correct core biological process; A4GALT catalyzes the LacCer-to-Gb3Cer step that initiates the globo-series of glycosphingolipids."
human	A4GALT	genes/human/A4GALT/A4GALT-ai-review.yaml	A4GALT	Q9NPC4	NCBITaxon:9606	Homo sapiens	7	R-HSA-9846477	A4GALT transfers galactose to LacCer	yes	reactome/R-HSA-9846477.md	A4GALT transfers galactose to LacCer	Homo sapiens	GO:0050512	lactosylceramide 4-alpha-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS annotation (reaction ""A4GALT transfers galactose to LacCer"") to the specific molecular function lactosylceramide 4-alpha-galactosyltransferase activity. This is the enzyme's core catalytic function and matches the experimental evidence."
human	A4GALT	genes/human/A4GALT/A4GALT-ai-review.yaml	A4GALT	Q9NPC4	NCBITaxon:9606	Homo sapiens	9	R-HSA-9846477	A4GALT transfers galactose to LacCer	yes	reactome/R-HSA-9846477.md	A4GALT transfers galactose to LacCer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to Golgi membrane. This is the correct specific compartment where A4GALT acts as a type II Golgi glycosyltransferase, consistent with the UniProt subcellular location.
human	A4GNT	genes/human/A4GNT/A4GNT-ai-review.yaml	A4GNT	Q9UNA3	NCBITaxon:9606	Homo sapiens	7	R-HSA-913709	O-linked glycosylation of mucins	yes	reactome/R-HSA-913709.md	O-linked glycosylation of mucins	Homo sapiens	GO:0016266	protein O-linked glycosylation via N-acetylgalactosamine	TAS	involved_in	BP	false		ACCEPT	A4GNT elaborates mucin O-glycans after the initiating GalNAc linkage, with the strongest activity on core 2 branched acceptors. This is within mucin-type O-GalNAc glycosylation.
human	A4GNT	genes/human/A4GNT/A4GNT-ai-review.yaml	A4GNT	Q9UNA3	NCBITaxon:9606	Homo sapiens	10	R-HSA-5694487	A4GNT transfers GlcNAc to core 2 mucins	yes	reactome/R-HSA-5694487.md	A4GNT transfers GlcNAc to core 2 mucins	Homo sapiens	GO:0008375	acetylglucosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome assigns A4GNT the transfer of GlcNAc to core 2 mucins, creating an alpha-1,4 linkage to beta-galactose residues.
human	A4GNT	genes/human/A4GNT/A4GNT-ai-review.yaml	A4GNT	Q9UNA3	NCBITaxon:9606	Homo sapiens	11	R-HSA-5694487	A4GNT transfers GlcNAc to core 2 mucins	yes	reactome/R-HSA-5694487.md	A4GNT transfers GlcNAc to core 2 mucins	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	The Reactome reaction assigns A4GNT to the Golgi membrane, consistent with human-tissue immunohistochemistry that localized the enzyme to the Golgi region of mucous cells.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	21	R-HSA-1176059	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	yes	reactome/R-HSA-1176059.md	Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	22	R-HSA-165043	Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC	yes	reactome/R-HSA-165043.md	Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	23	R-HSA-165047	Translocation of nuclear RNA transport complex to cytoplasm	yes	reactome/R-HSA-165047.md	Translocation of nuclear RNA transport complex to cytoplasm	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	24	R-HSA-170796	NPC transports GCK1:GCKR from cytosol to nucleoplasm	yes	reactome/R-HSA-170796.md	NPC transports GCK1:GCKR from cytosol to nucleoplasm	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	25	R-HSA-180622	Vpr binds nucleoporins	yes	reactome/R-HSA-180622.md	Vpr binds nucleoporins	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	26	R-HSA-192627	Viral mRNA Export	yes	reactome/R-HSA-192627.md	Viral mRNA Export	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	27	R-HSA-192925	Export of Spliced Viral mRNA	yes	reactome/R-HSA-192925.md	Export of Spliced Viral mRNA	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	28	R-HSA-2990880	NEK6/NEK7 phosphorylates NUP98	yes	reactome/R-HSA-2990880.md	NEK6/NEK7 phosphorylates NUP98	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	29	R-HSA-2990882	CDK1 phosphorylates NUP98	yes	reactome/R-HSA-2990882.md	CDK1 phosphorylates NUP98	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	30	R-HSA-3000348	RANBP2 SUMOylates SP100 with SUMO2	yes	reactome/R-HSA-3000348.md	RANBP2 SUMOylates SP100 with SUMO2	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	31	R-HSA-3000399	RANBP2 SUMOylates SP100 with SUMO1	yes	reactome/R-HSA-3000399.md	RANBP2 SUMOylates SP100 with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	32	R-HSA-3000411	RANBP2 SUMOylates PML with SUMO2	yes	reactome/R-HSA-3000411.md	RANBP2 SUMOylates PML with SUMO2	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	33	R-HSA-4551649	RANBP2 SUMOylates RANBP2 with SUMO1	yes	reactome/R-HSA-4551649.md	RANBP2 SUMOylates RANBP2 with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	34	R-HSA-4551679	RANBP2 SUMOylates RANBP2 with SUMO2	yes	reactome/R-HSA-4551679.md	RANBP2 SUMOylates RANBP2 with SUMO2	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	35	R-HSA-4570493	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1	yes	reactome/R-HSA-4570493.md	RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	36	R-HSA-4615872	RANBP2 SUMOylates HDAC4 with SUMO1	yes	reactome/R-HSA-4615872.md	RANBP2 SUMOylates HDAC4 with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	37	R-HSA-4615987	RANBP2 SUMOylates HDAC4 with SUMO2,3	yes	reactome/R-HSA-4615987.md	RANBP2 SUMOylates HDAC4 with SUMO2,3	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	38	R-HSA-4655355	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	yes	reactome/R-HSA-4655355.md	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	39	R-HSA-5228508	RANBP2 SUMOylates PML with SUMO1	yes	reactome/R-HSA-5228508.md	RANBP2 SUMOylates PML with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	40	R-HSA-5228523	RANBP2 SUMOylates MDM2 with SUMO1	yes	reactome/R-HSA-5228523.md	RANBP2 SUMOylates MDM2 with SUMO1	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	41	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	yes	reactome/R-HSA-5252041.md	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	42	R-HSA-5661474	Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm	yes	reactome/R-HSA-5661474.md	Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	43	R-HSA-6783483	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol	yes	reactome/R-HSA-6783483.md	tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	44	R-HSA-75096	Docking of the TAP:EJC Complex with the NPC	yes	reactome/R-HSA-75096.md	Docking of the TAP:EJC Complex with the NPC	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	45	R-HSA-75097	Transport of the export-competent mRNP complex through the NPC	yes	reactome/R-HSA-75097.md	Transport of the export-competent mRNP complex through the NPC	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	46	R-HSA-75098	mRNP complex dissociates from cytosolic face of NPC	yes	reactome/R-HSA-75098.md	mRNP complex dissociates from cytosolic face of NPC	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	47	R-HSA-9614367	HCMV Nuclear Pore Docking	yes	reactome/R-HSA-9614367.md	HCMV Nuclear Pore Docking	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	48	R-HSA-9614369	Transport of HCMV DNA Into the Nucleus	yes	reactome/R-HSA-9614369.md	Transport of HCMV DNA Into the Nucleus	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AAAS	genes/human/AAAS/AAAS-ai-review.yaml	AAAS	Q9NRG9	NCBITaxon:9606	Homo sapiens	49	R-HSA-9708889	SARS-CoV-2 6 binds NUP98:RAE1 within NPC	yes	reactome/R-HSA-9708889.md	SARS-CoV-2 6 binds NUP98:RAE1 within NPC	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	AAAS is correctly placed at the nuclear envelope/NPC, but the Reactome source event should be treated as location context only for this nuclear envelope row.
human	AACS	genes/human/AACS/AACS-ai-review.yaml	AACS	Q86V21	NCBITaxon:9606	Homo sapiens	7	R-HSA-77111	Synthesis of Ketone Bodies	yes	reactome/R-HSA-77111.md	Synthesis of Ketone Bodies	Homo sapiens	GO:0046951	ketone body biosynthetic process	TAS	involved_in	BP	false		MODIFY	Reactome:R-HSA-77111 is a mitochondrial hepatic ketone-body-synthesis pathway that contains the AACS reaction, but propagating the parent pathway term to AACS reverses the reaction's local direction: AACS consumes the ketone body acetoacetate in the cytosol to form acetoacetyl-CoA for downstream metabolism.
human	AACS	genes/human/AACS/AACS-ai-review.yaml	AACS	Q86V21	NCBITaxon:9606	Homo sapiens	8	R-HSA-5694494	AACS ligates CoA-SH to ACA, forming ACA-CoA	yes	reactome/R-HSA-5694494.md	AACS ligates CoA-SH to ACA, forming ACA-CoA	Homo sapiens	GO:0030729	acetoacetate-CoA ligase activity	TAS	enables	MF	false		ACCEPT	The human Reactome event states that AACS ligates CoA to acetoacetate to form acetoacetyl-CoA in the cytosol, which is precisely GO:0030729.
human	AACS	genes/human/AACS/AACS-ai-review.yaml	AACS	Q86V21	NCBITaxon:9606	Homo sapiens	10	R-HSA-5694494	AACS ligates CoA-SH to ACA, forming ACA-CoA	yes	reactome/R-HSA-5694494.md	AACS ligates CoA-SH to ACA, forming ACA-CoA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome reaction is explicitly cytosolic, consistent with AACS activation of acetoacetate outside mitochondria and with human-islet biochemical evidence.
human	AADAC	genes/human/AADAC/AADAC-ai-review.yaml	AADAC	P22760	NCBITaxon:9606	Homo sapiens	32	R-HSA-211945	Phase I - Functionalization of compounds	yes	reactome/R-HSA-211945.md	Phase I - Functionalization of compounds	Homo sapiens	GO:0006805	xenobiotic metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome places AADAC-mediated ester and amide hydrolysis in Phase I functionalization of xenobiotic compounds.
human	AADAC	genes/human/AADAC/AADAC-ai-review.yaml	AADAC	P22760	NCBITaxon:9606	Homo sapiens	33	R-HSA-5689000	AADAC deacetylates PHEN	yes	reactome/R-HSA-5689000.md	AADAC deacetylates PHEN	Homo sapiens	GO:0019213	deacetylase activity	TAS	enables	MF	false		ACCEPT	The Reactome reaction assigns AADAC-catalyzed phenacetin deacetylation to p-phenetidine, a well-established human AADAC drug-hydrolysis activity.
human	AADAC	genes/human/AADAC/AADAC-ai-review.yaml	AADAC	P22760	NCBITaxon:9606	Homo sapiens	34	R-HSA-5689000	AADAC deacetylates PHEN	yes	reactome/R-HSA-5689000.md	AADAC deacetylates PHEN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	AADAC is an integral single-pass endoplasmic-reticulum membrane protein; Reactome's catalyst placement at the ER membrane agrees with direct human localization data.
human	AADAT	genes/human/AADAT/AADAT-ai-review.yaml	AADAT	Q8N5Z0	NCBITaxon:9606	Homo sapiens	13	R-HSA-9972889	AADAT transaminates 3HKYN to xanthurenate	yes	reactome/R-HSA-9972889.md	AADAT transaminates 3HKYN to xanthurenate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation placing an AADAT activity (3-hydroxykynurenine to xanthurenate) in the cytosol; the cytosolic localization of human AADAT is inferred from rat work. A cytosolic pool is reported in the literature (KAT II described as soluble cytoplasmic), but the UniProt-authoritative core call is mitochondrion/matrix. Keep as non-core.
human	AADAT	genes/human/AADAT/AADAT-ai-review.yaml	AADAT	Q8N5Z0	NCBITaxon:9606	Homo sapiens	20	R-HSA-508561	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate	yes	reactome/R-HSA-508561.md	alpha-ketoadipate + glutamate <=> alpha-aminoadipate + alpha-ketoglutarate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the aminoadipate/2-oxoglutarate transaminase reaction of AADAT in the mitochondrial matrix. Consistent with the transit peptide and UniProt location. Accept as core compartment.
human	AADAT	genes/human/AADAT/AADAT-ai-review.yaml	AADAT	Q8N5Z0	NCBITaxon:9606	Homo sapiens	21	R-HSA-70952	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate	yes	reactome/R-HSA-70952.md	alpha-aminoadipate + alpha-ketoglutarate <=> alpha-ketoadipate + glutamate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (reverse aminoadipate reaction) placing AADAT in the mitochondrial matrix. Same compartment call as above; accept as core.
human	AADAT	genes/human/AADAT/AADAT-ai-review.yaml	AADAT	Q8N5Z0	NCBITaxon:9606	Homo sapiens	22	R-HSA-893583	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate	yes	reactome/R-HSA-893583.md	kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (kynurenine + 2-oxoglutarate reaction) placing AADAT in the mitochondrial matrix. Consistent with the UniProt location; accept as core.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	13	R-HSA-199991	Membrane Trafficking	yes	reactome/R-HSA-199991.md	Membrane Trafficking	Homo sapiens	GO:0061024	membrane organization	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome assigns AAK1 to the broad membrane-trafficking umbrella and maps that participation to membrane organization. This captures pathway context but is broader than AAK1's specific clathrin-mediated endocytic role.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	14	R-HSA-8856813	AAK1 phosphorylates AP-2 mu subunit at T156	yes	reactome/R-HSA-8856813.md	AAK1 phosphorylates AP-2 mu subunit at T156	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome represents AAK1 phosphorylating the AP-2 mu subunit and maps the event to protein serine/threonine kinase activity. This matches the core catalytic function established experimentally.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	19	R-HSA-8856808	Recruitment of AP-2 complex and clathrin	yes	reactome/R-HSA-8856808.md	Recruitment of AP-2 complex and clathrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The Reactome AP-2/clathrin recruitment event models AAK1 as cytosolic before or during recruitment to the endocytic machinery.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	20	R-HSA-8856813	AAK1 phosphorylates AP-2 mu subunit at T156	yes	reactome/R-HSA-8856813.md	AAK1 phosphorylates AP-2 mu subunit at T156	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The Reactome AP2M1 phosphorylation event assigns its AAK1 participant to the cytosol.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	21	R-HSA-8866283	ARBB recruits GPCRs into clathrin-coated pits	yes	reactome/R-HSA-8866283.md	ARBB recruits GPCRs into clathrin-coated pits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled recruitment of GPCRs to clathrin-coated pits.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	22	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the modeled F-/N-BAR protein recruitment phase of coated-pit maturation.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	23	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in a modeled nascent coated-pit cargo/CLASP recruitment event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	24	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the clathrin-dependent PIK3C2A recruitment event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	25	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled PIK3C2A phosphoinositide phosphorylation stage of coated-pit maturation.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	26	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled SNX9/actin-machinery recruitment stage of clathrin-mediated endocytosis.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	27	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in a modeled BAR-protein/dynamin recruitment event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	28	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled synaptojanin lipid-hydrolysis stage of coated-vesicle formation.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	29	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the modeled endophilin/synaptojanin recruitment event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	30	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled HSPA8-driven vesicle-uncoating event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	31	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the modeled recruitment of auxilins to clathrin-coated vesicles.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	32	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled auxilin/HSPA8 recruitment event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	33	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the modeled dynamin-mediated vesicle scission event.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	34	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic AAK1 in the modeled dissociation of AAK1 and dephosphorylation of AP2M1.
human	AAK1	genes/human/AAK1/AAK1-ai-review.yaml	AAK1	Q2M2I8	NCBITaxon:9606	Homo sapiens	35	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places AAK1 in the cytosol in the modeled RAB5/GAPVD1 binding phase of the AP-2 endocytic pathway.
human	AAMP	genes/human/AAMP/AAMP-ai-review.yaml	AAMP	Q13685	NCBITaxon:9606	Homo sapiens	10	R-HSA-9674529	AAMP binds to TBXA2R	yes	reactome/R-HSA-9674529.md	AAMP binds to TBXA2R	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic location asserted by the Reactome reaction ""AAMP binds to TBXA2R"". Correct compartment; the annotation is a by-product of Reactome modelling a specific binding event rather than independent localisation evidence."
human	AAMP	genes/human/AAMP/AAMP-ai-review.yaml	AAMP	Q13685	NCBITaxon:9606	Homo sapiens	11	R-HSA-9674531	AAMP binds EGFR	yes	reactome/R-HSA-9674531.md	AAMP binds EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic location from the Reactome reaction ""AAMP binds EGFR"". Same assessment as the other Reactome-derived cytosol annotations."
human	AAMP	genes/human/AAMP/AAMP-ai-review.yaml	AAMP	Q13685	NCBITaxon:9606	Homo sapiens	12	R-HSA-9674532	AAMP gene expression is positively regulated by VEGF	yes	reactome/R-HSA-9674532.md	AAMP gene expression is positively regulated by VEGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic location from the Reactome reaction ""AAMP gene expression is positively regulated by VEGF"". Consistent with PMID:26350504, which showed VEGF upregulates AAMP and recruits it to membrane protrusions. Correct compartment."
human	AAMP	genes/human/AAMP/AAMP-ai-review.yaml	AAMP	Q13685	NCBITaxon:9606	Homo sapiens	13	R-HSA-9676160	AAMP binds NOD2	yes	reactome/R-HSA-9676160.md	AAMP binds NOD2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic location from the Reactome reaction ""AAMP binds NOD2"", which models the innate-immune arm of AAMP function reported in PMID:19535145. Correct compartment for a cytosolic NLR interaction."
human	AANAT	genes/human/AANAT/AANAT-ai-review.yaml	AANAT	Q16613	NCBITaxon:9606	Homo sapiens	25	R-HSA-209931	Serotonin and melatonin biosynthesis	yes	reactome/R-HSA-209931.md	Serotonin and melatonin biosynthesis	Homo sapiens	GO:0046219	indolalkylamine biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS to indolalkylamine biosynthetic process. Serotonin, N-acetylserotonin and melatonin are indolalkylamines, so this is a correct (if more general) parent of the melatonin biosynthetic process that AANAT drives. Accurate but less specific than melatonin biosynthetic process; kept as a valid non-core generalization.
human	AANAT	genes/human/AANAT/AANAT-ai-review.yaml	AANAT	Q16613	NCBITaxon:9606	Homo sapiens	27	R-HSA-209792	N-acetylation of serotonin	yes	reactome/R-HSA-209792.md	N-acetylation of serotonin	Homo sapiens	GO:0004059	aralkylamine N-acetyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS assertion of the core aralkylamine N-acetyltransferase activity (N-acetylation of serotonin). Correct and consistent with experimental and phylogenetic evidence; accepted as the gene's core molecular function.
human	AANAT	genes/human/AANAT/AANAT-ai-review.yaml	AANAT	Q16613	NCBITaxon:9606	Homo sapiens	36	R-HSA-209792	N-acetylation of serotonin	yes	reactome/R-HSA-209792.md	N-acetylation of serotonin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the cytosol, consistent with the experimental cytosolic/cytoplasmic localization of AANAT; accepted as the core cellular location.
human	AARS1	genes/human/AARS1/AARS1-ai-review.yaml	AARS1	P49588	NCBITaxon:9606	Homo sapiens	23	R-HSA-379864	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate	yes	reactome/R-HSA-379864.md	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate	Homo sapiens	GO:0004813	alanine-tRNA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome assigns alanine-tRNA ligase activity to AARS1 in the cytosolic Ala-tRNA(Ala) reaction.
human	AARS1	genes/human/AARS1/AARS1-ai-review.yaml	AARS1	P49588	NCBITaxon:9606	Homo sapiens	35	R-HSA-379716	Cytosolic tRNA aminoacylation	yes	reactome/R-HSA-379716.md	Cytosolic tRNA aminoacylation	Homo sapiens	GO:0006418	tRNA aminoacylation for protein translation	TAS	involved_in	BP	false		MODIFY	Reactome places AARS1 in the broad cytosolic tRNA-aminoacylation pathway.
human	AARS1	genes/human/AARS1/AARS1-ai-review.yaml	AARS1	P49588	NCBITaxon:9606	Homo sapiens	46	R-HSA-379864	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate	yes	reactome/R-HSA-379864.md	alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places AARS1 in the cytosol for its alanine-tRNA charging reaction.
human	AASDHPPT	genes/human/AASDHPPT/AASDHPPT-ai-review.yaml	AASDHPPT	Q9NRN7	NCBITaxon:9606	Homo sapiens	13	R-HSA-199220	Vitamin B5 (pantothenate) metabolism	yes	reactome/R-HSA-199220.md	Vitamin B5 (pantothenate) metabolism	Homo sapiens	GO:0015939	pantothenate metabolic process	TAS	involved_in	BP	false		MODIFY	Placement of AASDHPPT in Reactome's vitamin B5 pathway reflects use of CoA-derived phosphopantetheine, but pantothenate metabolism is not the reaction catalyzed by this enzyme.
human	AASDHPPT	genes/human/AASDHPPT/AASDHPPT-ai-review.yaml	AASDHPPT	Q9NRN7	NCBITaxon:9606	Homo sapiens	14	R-HSA-199202	Phosphopantetheine conjugation of the ACP domain of FAS	yes	reactome/R-HSA-199202.md	Phosphopantetheine conjugation of the ACP domain of FAS	Homo sapiens	GO:0008897	holo-[acyl-carrier-protein] synthase activity	TAS	enables	MF	false		ACCEPT	Reactome explicitly assigns AASDHPPT the transfer of phosphopantetheine from CoA to the ACP domain of FASN, matching the GO molecular function.
human	AASDHPPT	genes/human/AASDHPPT/AASDHPPT-ai-review.yaml	AASDHPPT	Q9NRN7	NCBITaxon:9606	Homo sapiens	27	R-HSA-199202	Phosphopantetheine conjugation of the ACP domain of FAS	yes	reactome/R-HSA-199202.md	Phosphopantetheine conjugation of the ACP domain of FAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the FASN ACP phosphopantetheinylation reaction and its catalyst AASDHPPT in the cytosol.
human	AASS	genes/human/AASS/AASS-ai-review.yaml	AASS	Q9UDR5	NCBITaxon:9606	Homo sapiens	8	R-HSA-70938	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O	yes	reactome/R-HSA-70938.md	lysine + alpha-ketoglutarate +NADPH + H+ => saccharopine + NADP+ + H2O	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the LKR reaction of human AASS in the mitochondrial matrix.
human	AASS	genes/human/AASS/AASS-ai-review.yaml	AASS	Q9UDR5	NCBITaxon:9606	Homo sapiens	9	R-HSA-70940	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+	yes	reactome/R-HSA-70940.md	saccharopine + NAD+ + H2O => alpha-aminoadipic semialdehyde + glutamate + NADH + H+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the SDH reaction of human AASS in the mitochondrial matrix.
human	ABAT	genes/human/ABAT/ABAT-ai-review.yaml	ABAT	P80404	NCBITaxon:9606	Homo sapiens	37	R-HSA-916855	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA	yes	reactome/R-HSA-916855.md	PXLP-K357-ABAT dimer:2Fe-2S transforms GABA to SUCCSA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Traceable-author-statement (Reactome) localization to the mitochondrial matrix, where the GABA -> succinate semialdehyde reaction occurs. This is the most specific correct localization for ABAT.
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	99	R-HSA-5682111	Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane	yes	reactome/R-HSA-5682111.md	Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	100	R-HSA-5682084	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer	yes	reactome/R-HSA-5682084.md	ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ABCA1 is synthesized and folded in the ER membrane before trafficking to the cell surface; ER residence is biosynthetic, not its active site (TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	101	R-HSA-5682103	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane	yes	reactome/R-HSA-5682103.md	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ABCA1 is synthesized and folded in the ER membrane before trafficking to the cell surface; ER residence is biosynthetic, not its active site (TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	102	R-HSA-216723	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane	yes	reactome/R-HSA-216723.md	4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	103	R-HSA-216727	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1	yes	reactome/R-HSA-216727.md	4xPALM-C-p-2S-ABCA1 tetramer binds APOA1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	104	R-HSA-216757	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane	yes	reactome/R-HSA-216757.md	4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	105	R-HSA-5682101	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer	yes	reactome/R-HSA-5682101.md	PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	106	R-HSA-5682103	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane	yes	reactome/R-HSA-5682103.md	4xPALM-C-ABCA1 tetramer translocates from ER membrane to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	112	R-HSA-1989765	Expression of ABCA1	yes	reactome/R-HSA-1989765.md	Expression of ABCA1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	113	R-HSA-9618479	ABCA1 mRNA is translated	yes	reactome/R-HSA-9618479.md	ABCA1 mRNA is translated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA1	genes/human/ABCA1/ABCA1-ai-review.yaml	ABCA1	O95477	NCBITaxon:9606	Homo sapiens	114	R-HSA-9619756	NR1H2 binds ABCA1	yes	reactome/R-HSA-9619756.md	NR1H2 binds ABCA1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCA1 is a multi-pass plasma-membrane protein; the cell surface is where it docks apoA-I and effluxes lipid. Best-supported localization (n=17; IDA/IMP/TAS).
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	2	R-HSA-5683672	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5683672.md	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0005319	lipid carrier activity	TAS	enables	MF	false		ACCEPT	ABCA3 is an ATP-dependent membrane lipid carrier.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	3	R-HSA-5683714	ABCA3 transports PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5683714.md	ABCA3 transports PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0005319	lipid carrier activity	TAS	enables	MF	false		ACCEPT	ABCA3 is an ATP-dependent membrane lipid carrier.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	4	R-HSA-5688397	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5688397.md	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0005319	lipid carrier activity	TAS	enables	MF	false		ACCEPT	ABCA3 is an ATP-dependent membrane lipid carrier.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	19	R-HSA-1369062	ABC transporters in lipid homeostasis	yes	reactome/R-HSA-1369062.md	ABC transporters in lipid homeostasis	Homo sapiens	GO:0006869	lipid transport	TAS	involved_in	BP	false		ACCEPT	Lipid transport is the central activity-dependent process of ABCA3.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	64	R-HSA-5683672	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5683672.md	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0097232	lamellar body membrane	TAS	located_in	CC	false		ACCEPT	The limiting membrane of alveolar lamellar bodies is the main physiological site of ABCA3.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	65	R-HSA-5683714	ABCA3 transports PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5683714.md	ABCA3 transports PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0097232	lamellar body membrane	TAS	located_in	CC	false		ACCEPT	The limiting membrane of alveolar lamellar bodies is the main physiological site of ABCA3.
human	ABCA3	genes/human/ABCA3/ABCA3-ai-review.yaml	ABCA3	Q99758	NCBITaxon:9606	Homo sapiens	66	R-HSA-5688397	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	yes	reactome/R-HSA-5688397.md	Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body	Homo sapiens	GO:0097232	lamellar body membrane	TAS	located_in	CC	false		ACCEPT	The limiting membrane of alveolar lamellar bodies is the main physiological site of ABCA3.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	2	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	ABCA4 participates in retinal/retinoid handling by moving the retinal-PE adduct to the cytosolic disc leaflet for subsequent retinal release and reduction.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	36	R-HSA-1467466	ABCA4 mediates atRAL transport	yes	reactome/R-HSA-1467466.md	ABCA4 mediates atRAL transport	Homo sapiens	GO:0034632	retinol transmembrane transporter activity	TAS	enables	MF	false		MODIFY	The Reactome event describes retinal or NRPE handling, but the assigned GO term denotes retinol, the corresponding alcohol.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	37	R-HSA-2466802	Defective ABCA4 does not transport NRPE from disc membranes	yes	reactome/R-HSA-2466802.md	Defective ABCA4 does not transport NRPE from disc membranes	Homo sapiens	GO:0034632	retinol transmembrane transporter activity	TAS	enables	MF	false		MODIFY	The Reactome event describes retinal or NRPE handling, but the assigned GO term denotes retinol, the corresponding alcohol.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	47	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		MODIFY	The transport performed by ABCA4 is phospholipid translocation between the two membrane leaflets.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	49	R-HSA-1467466	ABCA4 mediates atRAL transport	yes	reactome/R-HSA-1467466.md	ABCA4 mediates atRAL transport	Homo sapiens	GO:0097381	photoreceptor disc membrane	TAS	located_in	CC	false		ACCEPT	ABCA4 acts in photoreceptor outer-segment disc membranes, particularly at rims and incisures; the rod-disc annotation describes a well-established location.
human	ABCA4	genes/human/ABCA4/ABCA4-ai-review.yaml	ABCA4	P78363	NCBITaxon:9606	Homo sapiens	50	R-HSA-2466802	Defective ABCA4 does not transport NRPE from disc membranes	yes	reactome/R-HSA-2466802.md	Defective ABCA4 does not transport NRPE from disc membranes	Homo sapiens	GO:0097381	photoreceptor disc membrane	TAS	located_in	CC	false		ACCEPT	ABCA4 acts in photoreceptor outer-segment disc membranes, particularly at rims and incisures; the rod-disc annotation describes a well-established location.
human	ABCA7	genes/human/ABCA7/ABCA7-ai-review.yaml	ABCA7	Q8IZY2	NCBITaxon:9606	Homo sapiens	29	R-HSA-1369062	ABC transporters in lipid homeostasis	yes	reactome/R-HSA-1369062.md	ABC transporters in lipid homeostasis	Homo sapiens	GO:0006869	lipid transport	TAS	involved_in	BP	false		ACCEPT	This annotation is part of the core lipid transport, phospholipid efflux, or membrane-trafficking function of ABCA7.
human	ABCA7	genes/human/ABCA7/ABCA7-ai-review.yaml	ABCA7	Q8IZY2	NCBITaxon:9606	Homo sapiens	33	R-HSA-382553	ABCA7:Apo1A-mediated phospholipid efflux	yes	reactome/R-HSA-382553.md	ABCA7:Apo1A-mediated phospholipid efflux	Homo sapiens	GO:0120014	phospholipid transfer activity	TAS	enables	MF	false		ACCEPT	This molecular-function annotation captures the core ABCA7 activity: ATP-coupled intramembrane phospholipid transport/floppase activity and apoA-I-associated phospholipid efflux.
human	ABCA7	genes/human/ABCA7/ABCA7-ai-review.yaml	ABCA7	Q8IZY2	NCBITaxon:9606	Homo sapiens	81	R-HSA-382553	ABCA7:Apo1A-mediated phospholipid efflux	yes	reactome/R-HSA-382553.md	ABCA7:Apo1A-mediated phospholipid efflux	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This location fits ABCA7 function as a multipass membrane lipid transporter active at plasma, Golgi/endosomal, ruffle, and phagocytic-cup membranes.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	13	R-HSA-1989762	Expression of ABCB4	yes	reactome/R-HSA-1989762.md	Expression of ABCB4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCB4 is an integral plasma-membrane transporter.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	14	R-HSA-5678706	ABCB4 transports PC from plasma membrane to extracellular region	yes	reactome/R-HSA-5678706.md	ABCB4 transports PC from plasma membrane to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCB4 is an integral plasma-membrane transporter.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	15	R-HSA-5678749	Defective ABCB4 does not transport PC from plasma membrane to extracellular region	yes	reactome/R-HSA-5678749.md	Defective ABCB4 does not transport PC from plasma membrane to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ABCB4 is an integral plasma-membrane transporter.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	46	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		ACCEPT	ABCB4 contributes a lipid-transport step to the ABC transport pathway.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	59	R-HSA-5678706	ABCB4 transports PC from plasma membrane to extracellular region	yes	reactome/R-HSA-5678706.md	ABCB4 transports PC from plasma membrane to extracellular region	Homo sapiens	GO:0120014	phospholipid transfer activity	TAS	enables	MF	false		MODIFY	The Reactome PC-export event is executed by a membrane floppase.
human	ABCB4	genes/human/ABCB4/ABCB4-ai-review.yaml	ABCB4	P21439	NCBITaxon:9606	Homo sapiens	60	R-HSA-5678749	Defective ABCB4 does not transport PC from plasma membrane to extracellular region	yes	reactome/R-HSA-5678749.md	Defective ABCB4 does not transport PC from plasma membrane to extracellular region	Homo sapiens	GO:0120014	phospholipid transfer activity	TAS	enables	MF	false		MODIFY	The Reactome PC-export event is executed by a membrane floppase.
human	ABCB7	genes/human/ABCB7/ABCB7-ai-review.yaml	ABCB7	O75027	NCBITaxon:9606	Homo sapiens	38	R-HSA-382560	ABC7, mABC1 and mABC2 mediate heme transport	yes	reactome/R-HSA-382560.md	ABC7, mABC1 and mABC2 mediate heme transport	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway. Note that the Reactome pathway name referring to heme transport is outdated - ABCB7 transports Fe-S clusters.
human	ABCC6	genes/human/ABCC6/ABCC6-ai-review.yaml	ABCC6	O95255	NCBITaxon:9606	Homo sapiens	31	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Full-length ABCC6 is a plasma-membrane transporter.
human	ABCC6	genes/human/ABCC6/ABCC6-ai-review.yaml	ABCC6	O95255	NCBITaxon:9606	Homo sapiens	32	R-HSA-5690340	Defective ABCC6 does not transport organic anion from cytosol to extracellular region	yes	reactome/R-HSA-5690340.md	Defective ABCC6 does not transport organic anion from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Full-length ABCC6 is a plasma-membrane transporter.
human	ABCC6	genes/human/ABCC6/ABCC6-ai-review.yaml	ABCC6	O95255	NCBITaxon:9606	Homo sapiens	54	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0042626	ATPase-coupled transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	ABCC6 is an ATPase-coupled primary active membrane transporter.
human	ABCC6	genes/human/ABCC6/ABCC6-ai-review.yaml	ABCC6	O95255	NCBITaxon:9606	Homo sapiens	55	R-HSA-5690340	Defective ABCC6 does not transport organic anion from cytosol to extracellular region	yes	reactome/R-HSA-5690340.md	Defective ABCC6 does not transport organic anion from cytosol to extracellular region	Homo sapiens	GO:0042626	ATPase-coupled transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	ABCC6 is an ATPase-coupled primary active membrane transporter.
human	ABCC6	genes/human/ABCC6/ABCC6-ai-review.yaml	ABCC6	O95255	NCBITaxon:9606	Homo sapiens	64	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		ACCEPT	ABCC6 directly performs transmembrane transport.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	6	R-HSA-265682	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel	yes	reactome/R-HSA-265682.md	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel	Homo sapiens	GO:0005524	ATP binding	TAS	enables	MF	false		ACCEPT	SUR1 directly binds ATP in its ABC nucleotide-binding domains.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	10	R-HSA-1296024	Activation of ATP sensitive Potassium channels in neuroendocrine cells	yes	reactome/R-HSA-1296024.md	Activation of ATP sensitive Potassium channels in neuroendocrine cells	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	11	R-HSA-265682	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel	yes	reactome/R-HSA-265682.md	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	12	R-HSA-5683113	Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia	yes	reactome/R-HSA-5683113.md	Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	13	R-HSA-5683209	Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)	yes	reactome/R-HSA-5683209.md	Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	14	R-HSA-9650858	Meglitinides bind ABCC8	yes	reactome/R-HSA-9650858.md	Meglitinides bind ABCC8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	15	R-HSA-9652580	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)	yes	reactome/R-HSA-9652580.md	SU drugs bind ABCC8 (in KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Mature SUR1-containing KATP channels function at the plasma membrane.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	30	R-HSA-5683209	Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)	yes	reactome/R-HSA-5683209.md	Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)	Homo sapiens	GO:0015272	ATP-activated inward rectifier potassium channel activity	TAS	enables	MF	false		MODIFY	Activating SUR1 variants alter regulation of a separate potassium pore.
human	ABCC8	genes/human/ABCC8/ABCC8-ai-review.yaml	ABCC8	Q09428	NCBITaxon:9606	Homo sapiens	51	R-HSA-422356	Regulation of insulin secretion	yes	reactome/R-HSA-422356.md	Regulation of insulin secretion	Homo sapiens	GO:0050796	regulation of insulin secretion	TAS	involved_in	BP	false		ACCEPT	SUR1 couples metabolic nucleotide signals to insulin secretion.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	11	R-HSA-1369017	Activation of ATP sensitive Potassium channels in muscle cells	yes	reactome/R-HSA-1369017.md	Activation of ATP sensitive Potassium channels in muscle cells	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome record places SUR2-containing channels at the plasma membrane.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	12	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome record places SUR2-containing channels at the plasma membrane.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	13	R-HSA-5678261	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol	yes	reactome/R-HSA-5678261.md	KCNJ11:ABCC9 transports K+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome record places SUR2-containing channels at the plasma membrane.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	14	R-HSA-5678418	Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol	yes	reactome/R-HSA-5678418.md	Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome record places SUR2-containing channels at the plasma membrane.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	15	R-HSA-9691566	KCNJ11:ABCC9 binds nicorandil	yes	reactome/R-HSA-9691566.md	KCNJ11:ABCC9 binds nicorandil	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome record places SUR2-containing channels at the plasma membrane.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	36	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0042626	ATPase-coupled transmembrane transporter activity	TAS	enables	MF	false		MODIFY	The family-level Reactome mapping assigns active transport too broadly to a nontransporting channel regulator.
human	ABCC9	genes/human/ABCC9/ABCC9-ai-review.yaml	ABCC9	O60706	NCBITaxon:9606	Homo sapiens	42	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		MODIFY	SUR2 contributes specifically to potassium movement across the plasma membrane as a channel regulator.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	9	R-HSA-5684043	Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix	yes	reactome/R-HSA-5684043.md	Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix	Homo sapiens	GO:0005324	long-chain fatty acid transmembrane transporter activity	TAS	enables	MF	false		MODIFY	ABCD1 recognizes fatty-acyl-CoA substrates for ATP-dependent peroxisomal import.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	43	R-HSA-2046087	Translocation of tetracosahexaenoyl-CoA to peroxisomes	yes	reactome/R-HSA-2046087.md	Translocation of tetracosahexaenoyl-CoA to peroxisomes	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	44	R-HSA-2046093	Translocation of tetracosapentaenoyl-CoA to peroxisomes	yes	reactome/R-HSA-2046093.md	Translocation of tetracosapentaenoyl-CoA to peroxisomes	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	45	R-HSA-382575	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix	yes	reactome/R-HSA-382575.md	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	46	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	47	R-HSA-390393	Peroxisomal uptake of very long-chain fatty acyl CoA	yes	reactome/R-HSA-390393.md	Peroxisomal uptake of very long-chain fatty acyl CoA	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	48	R-HSA-5684043	Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix	yes	reactome/R-HSA-5684043.md	Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	49	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	The peroxisomal membrane is the principal functional site of ABCD1.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	52	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nascent ABCD1 can be a PEX19-bound cytosolic client before membrane insertion.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	53	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	This dissociation event leaves the ABCD1-class cargo in the peroxisomal membrane.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	54	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nascent ABCD1 can be a PEX19-bound cytosolic client before membrane insertion.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	55	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nascent ABCD1 can be a PEX19-bound cytosolic client before membrane insertion.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	91	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Polyunsaturated-fatty-acid pathway participation is broader and less characteristic than saturated VLCFA import.
human	ABCD1	genes/human/ABCD1/ABCD1-ai-review.yaml	ABCD1	P33897	NCBITaxon:9606	Homo sapiens	109	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Polyunsaturated-fatty-acid pathway participation is broader and less characteristic than saturated VLCFA import.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	31	R-HSA-382575	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix	yes	reactome/R-HSA-382575.md	ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix. Consistent with ABCD3 function.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	32	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PEX19 docks ABCD3 to peroxisomal membrane.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	33	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PEX3:PEX19:class I PMP dissociates. ABCD3 is a class I PMP.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	34	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome: PEX19 docks ABCD3 to peroxisomal membrane, implying ABCD3 transits through cytosol during biogenesis. ABCD3 is synthesized on free ribosomes and targeted posttranslationally [PMID:17761678].
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	35	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome: PEX3:PEX19:class I PMP complex dissociation. Transient cytosolic location during import pathway.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	36	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome: PEX19:class I PMP binds PEX3. Part of peroxisomal membrane protein import.
human	ABCD3	genes/human/ABCD3/ABCD3-ai-review.yaml	ABCD3	P28288	NCBITaxon:9606	Homo sapiens	37	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome: PEX19 binds class I peroxisomal membrane proteins in cytosol.
human	ABCD4	genes/human/ABCD4/ABCD4-ai-review.yaml	ABCD4	O14678	NCBITaxon:9606	Homo sapiens	23	R-HSA-9758881	Uptake of dietary cobalamins into enterocytes	yes	reactome/R-HSA-9758881.md	Uptake of dietary cobalamins into enterocytes	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in cobalamin transport (dietary cobalamin uptake pathway). This is the core biological process of ABCD4.
human	ABCD4	genes/human/ABCD4/ABCD4-ai-review.yaml	ABCD4	O14678	NCBITaxon:9606	Homo sapiens	24	R-HSA-9758890	Transport of RCbl within the body	yes	reactome/R-HSA-9758890.md	Transport of RCbl within the body	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in cobalamin transport (transport of RCbl within the body). Core biological process of ABCD4.
human	ABCD4	genes/human/ABCD4/ABCD4-ai-review.yaml	ABCD4	O14678	NCBITaxon:9606	Homo sapiens	43	R-HSA-5683325	Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol	yes	reactome/R-HSA-5683325.md	Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal membrane localization (defective-transport event). Consistent with all experimental localization data.
human	ABCD4	genes/human/ABCD4/ABCD4-ai-review.yaml	ABCD4	O14678	NCBITaxon:9606	Homo sapiens	44	R-HSA-5223313	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)	yes	reactome/R-HSA-5223313.md	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal membrane localization (RCbl transport in gut mucosal cells). Consistent with experimental data.
human	ABCD4	genes/human/ABCD4/ABCD4-ai-review.yaml	ABCD4	O14678	NCBITaxon:9606	Homo sapiens	45	R-HSA-9759206	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol	yes	reactome/R-HSA-9759206.md	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal membrane localization (ABCD4-LMBRD1 transports RCbl from lysosomal lumen to cytosol). Consistent with experimental data.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	17	R-HSA-9948299	Ribosome-associated quality control	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Reactome places ABCE1 downstream of PELO/HBS1L in rescue of non-stop or stalled cytosolic ribosomes, where ABCE1 hydrolyzes ATP to split the 80S ribosome.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	18	R-HSA-9955731	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA	yes	reactome/R-HSA-9955731.md	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	Reactome explicitly describes ABCE1 hydrolyzing ATP while bound with PELO to split a stalled 80S ribosome.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	30	R-HSA-8985201	ABCE1 binds RNASEL	yes	reactome/R-HSA-8985201.md	ABCE1 binds RNASEL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's RNASEL binding event places ABCE1/RLI in the cytoplasm and describes its RNase L inhibitory role.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	31	R-HSA-9954919	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome describes the cytosolic stalled-ribosome rescue pathway in which HBS1L dissociation exposes PELO for ABCE1 binding.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	32	R-HSA-9955731	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA	yes	reactome/R-HSA-9955731.md	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome describes ABCE1-bound PELO hydrolyzing ATP to dissociate a stalled cytosolic 80S ribosome.
human	ABCE1	genes/human/ABCE1/ABCE1-ai-review.yaml	ABCE1	P61221	NCBITaxon:9606	Homo sapiens	37	R-HSA-5223305	ABCE1 binds RNASEL, inhibiting it	yes	reactome/R-HSA-5223305.md	ABCE1 binds RNASEL, inhibiting it	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MODIFY	Mitochondrial association of ABCE1/RLI is supported, but the more specific mitochondrial matrix location is not clearly justified by the cited RNASEL inhibition event.
human	ABCF2	genes/human/ABCF2/ABCF2-ai-review.yaml	ABCF2	Q9UG63	NCBITaxon:9606	Homo sapiens	5	R-HSA-9796042	NFE2L2 dependent ABCF2 expression	yes	reactome/R-HSA-9796042.md	NFE2L2 dependent ABCF2 expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		REMOVE	Reactome models NFE2L2-dependent ABCF2 expression, but the primary evidence supports ABCF2 as a cytosolic, non-transmembrane ABCF protein rather than a plasma membrane transporter.
human	ABCG5	genes/human/ABCG5/ABCG5-ai-review.yaml	ABCG5	Q9H222	NCBITaxon:9606	Homo sapiens	8	R-HSA-265783	ABCG5:ABCG8 transports sterols from cytosol to extracellular region	yes	reactome/R-HSA-265783.md	ABCG5:ABCG8 transports sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome sterol-export event places the transporter in the plasma membrane.
human	ABCG5	genes/human/ABCG5/ABCG5-ai-review.yaml	ABCG5	Q9H222	NCBITaxon:9606	Homo sapiens	9	R-HSA-5679101	Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	yes	reactome/R-HSA-5679101.md	Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The defective-ABCG8 event retains the normal complex membrane context.
human	ABCG5	genes/human/ABCG5/ABCG5-ai-review.yaml	ABCG5	Q9H222	NCBITaxon:9606	Homo sapiens	10	R-HSA-5679145	Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	yes	reactome/R-HSA-5679145.md	Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The defective-ABCG5 event retains the normal complex membrane context.
human	ABCG5	genes/human/ABCG5/ABCG5-ai-review.yaml	ABCG5	Q9H222	NCBITaxon:9606	Homo sapiens	11	R-HSA-9029531	Expression of ABCG5 regulated by NR1H2,3	yes	reactome/R-HSA-9029531.md	Expression of ABCG5 regulated by NR1H2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The expression event identifies ABCG5 as a plasma-membrane transporter product.
human	ABCG8	genes/human/ABCG8/ABCG8-ai-review.yaml	ABCG8	Q9H221	NCBITaxon:9606	Homo sapiens	8	R-HSA-265783	ABCG5:ABCG8 transports sterols from cytosol to extracellular region	yes	reactome/R-HSA-265783.md	ABCG5:ABCG8 transports sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome sterol-export reaction places ABCG8 in the plasma membrane.
human	ABCG8	genes/human/ABCG8/ABCG8-ai-review.yaml	ABCG8	Q9H221	NCBITaxon:9606	Homo sapiens	9	R-HSA-5679101	Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	yes	reactome/R-HSA-5679101.md	Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The disease-pathway record retains the normal complex’s plasma-membrane compartment.
human	ABCG8	genes/human/ABCG8/ABCG8-ai-review.yaml	ABCG8	Q9H221	NCBITaxon:9606	Homo sapiens	10	R-HSA-5679145	Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	yes	reactome/R-HSA-5679145.md	Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The disease-pathway record retains the normal complex’s plasma-membrane compartment.
human	ABCG8	genes/human/ABCG8/ABCG8-ai-review.yaml	ABCG8	Q9H221	NCBITaxon:9606	Homo sapiens	11	R-HSA-9029591	Expression of ABCG8 regulated by NR1H2 or NR1H3	yes	reactome/R-HSA-9029591.md	Expression of ABCG8 regulated by NR1H2 or NR1H3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The regulated-expression pathway correctly describes the location of the ABCG8 product.
human	ABHD12	genes/human/ABHD12/ABHD12-ai-review.yaml	ABHD12	Q8N2K0	NCBITaxon:9606	Homo sapiens	7	R-HSA-5694462	ABHD6,12 hydrolyse 3AG	yes	reactome/R-HSA-5694462.md	ABHD6,12 hydrolyse 3AG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the monoacylglycerol-hydrolyzing ABHD12 pool at the plasma membrane.
human	ABHD12	genes/human/ABHD12/ABHD12-ai-review.yaml	ABHD12	Q8N2K0	NCBITaxon:9606	Homo sapiens	16	R-HSA-426048	Arachidonate production from DAG	yes	reactome/R-HSA-426048.md	Arachidonate production from DAG	Homo sapiens	GO:0019369	arachidonate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Monoacylglycerol hydrolysis can release arachidonate.
human	ABHD12	genes/human/ABHD12/ABHD12-ai-review.yaml	ABHD12	Q8N2K0	NCBITaxon:9606	Homo sapiens	26	R-HSA-5694462	ABHD6,12 hydrolyse 3AG	yes	reactome/R-HSA-5694462.md	ABHD6,12 hydrolyse 3AG	Homo sapiens	GO:0047372	monoacylglycerol lipase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	The Reactome reaction captures ABHD12 hydrolysis of arachidonoylglycerol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	226	R-HSA-428888	Reactome - ESR-mediated signaling	yes	reactome/R-HSA-428888.md	Phosphorylation of ROBO1 by ABL kinase	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	ABL1 tyrosine kinase activity in Reactome pathway.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	227	R-HSA-5686587	Reactome - Lysosome	yes	reactome/R-HSA-5686587.md	ABL1 phosphorylates RAD52	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	ABL1 tyrosine kinase activity in Reactome pathway.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	228	R-HSA-8956659	Reactome - ABL1 signaling events	yes	reactome/R-HSA-8956659.md	ABL1 phosphorylates YAP1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	ABL1 tyrosine kinase activity in Reactome pathway.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	229	R-HSA-9841924	Reactome - ABL1 signaling in DNA damage response	yes	reactome/R-HSA-9841924.md	ABL1 phosphorylates PPARG2	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	ABL1 tyrosine kinase activity.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	230	R-HSA-9865196	Reactome - ABL1 kinase activity	yes	reactome/R-HSA-9865196.md	p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	ABL1 tyrosine kinase activity.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	233	R-HSA-5686578	Reactome - Autophagy	yes	reactome/R-HSA-5686578.md	Activated ATM phosphorylates ABL1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to nucleoplasm.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	234	R-HSA-5686587	Reactome - Lysosome	yes	reactome/R-HSA-5686587.md	ABL1 phosphorylates RAD52	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to nucleoplasm.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	235	R-HSA-8956659	Reactome - ABL1 signaling events	yes	reactome/R-HSA-8956659.md	ABL1 phosphorylates YAP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to nucleoplasm.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	236	R-HSA-9841924	Reactome - ABL1 signaling in DNA damage response	yes	reactome/R-HSA-9841924.md	ABL1 phosphorylates PPARG2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to nucleoplasm.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	237	R-HSA-9842028	Reactome - DNA damage checkpoint signaling	yes	reactome/R-HSA-9842028.md	ABL1 binds PPARG2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to nucleoplasm.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	240	R-HSA-2130194	Reactome - EPH-ephrin signaling	yes	reactome/R-HSA-2130194.md	ABL phosphorylates WAVEs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 localizes to cytosol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	241	R-HSA-376141	Reactome - Termination of O-glycan biosynthesis	yes	reactome/R-HSA-376141.md	Interaction of ABL with ROBO1:SLIT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 in cytosol (Reactome pathway).
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	242	R-HSA-428888	Reactome - ESR-mediated signaling	yes	reactome/R-HSA-428888.md	Phosphorylation of ROBO1 by ABL kinase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 in cytosol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	243	R-HSA-448958	Reactome - Axon guidance	yes	reactome/R-HSA-448958.md	Nuclear translocation of p38 MAPK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 in cytosol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	244	R-HSA-9865184	Reactome - ABL1 cytosolic signaling	yes	reactome/R-HSA-9865184.md	Phosphorylation of ABL1 on tyrosine-393 in response to oscillatory shear stress	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 in cytosol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	245	R-HSA-9865196	Reactome - ABL1 kinase activity	yes	reactome/R-HSA-9865196.md	p-Y393-ABL1 phosphorylates tyrosine-407 of YAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ABL1 in cytosol.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	257	R-HSA-2029480	Reactome - Fcgamma receptor (FCGR) dependent phagocytosis	yes	reactome/R-HSA-2029480.md	Fcgamma receptor (FCGR) dependent phagocytosis	Homo sapiens	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ABL1 involved in Fc-gamma receptor signaling.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	258	R-HSA-9664422	Reactome - Fc-gamma receptor signaling	yes	reactome/R-HSA-9664422.md	FCGR3A-mediated phagocytosis	Homo sapiens	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ABL1 in Fc-gamma receptor signaling.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	263	R-HSA-9860927	Reactome - Endothelial cell response to shear stress	yes	reactome/R-HSA-9860927.md	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Homo sapiens	GO:0097706	vascular endothelial cell response to oscillatory fluid shear stress	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ABL1 involved in endothelial shear stress response.
human	ABL1	genes/human/ABL1/ABL1-ai-review.yaml	ABL1	P00519	NCBITaxon:9606	Homo sapiens	265	R-HSA-8939236	Reactome - RUNX1 regulates transcription of genes involved in differentiation of HSCs	yes	reactome/R-HSA-8939236.md	RUNX1 regulates transcription of genes involved in differentiation of HSCs	Homo sapiens	GO:1902036	regulation of hematopoietic stem cell differentiation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ABL1 regulates hematopoietic stem cell differentiation.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	15	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		ACCEPT	The correct least common ancestor of ABR's regulatory range, and the target chosen for the four vague domain-derived process rows.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	17	R-HSA-9014296	RAC2 GEFs activate RAC2	yes	reactome/R-HSA-9014296.md	RAC2 GEFs activate RAC2	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	Traceable Reactome statement crediting the primary GEF biochemistry.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	18	R-HSA-9013022	RHOB GAPs stimulate RHOB GTPase activity	yes	reactome/R-HSA-9013022.md	RHOB GAPs stimulate RHOB GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	Correct term. The RHOB substrate assignment behind it is in apparent tension with the 1995 biochemistry, and the resolution is that both measured an isolated, intrinsically nonselective domain.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	27	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Correct resting-state compartment; not where the activity is exercised.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	28	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Correct resting-state compartment; not where the activity is exercised.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	29	R-HSA-9013022	RHOB GAPs stimulate RHOB GTPase activity	yes	reactome/R-HSA-9013022.md	RHOB GAPs stimulate RHOB GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Correct resting-state compartment; not where the activity is exercised.
human	ABR	genes/human/ABR/ABR-ai-review.yaml	ABR	Q12979	NCBITaxon:9606	Homo sapiens	30	R-HSA-9014296	RAC2 GEFs activate RAC2	yes	reactome/R-HSA-9014296.md	RAC2 GEFs activate RAC2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Correct resting-state compartment; not where the activity is exercised.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	24	R-HSA-5683384	UIMC1 and FAM175A bind DNA DSBs	yes	reactome/R-HSA-5683384.md	UIMC1 and FAM175A bind DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	25	R-HSA-5683385	Formation of BRCA1-A complex at DNA DSBs	yes	reactome/R-HSA-5683385.md	Formation of BRCA1-A complex at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	26	R-HSA-5683735	CHEK2 is recruited to DNA DSBs	yes	reactome/R-HSA-5683735.md	CHEK2 is recruited to DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	27	R-HSA-5683801	CHEK2 phosphorylates BRCA1	yes	reactome/R-HSA-5683801.md	CHEK2 phosphorylates BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	28	R-HSA-5684052	PIAS4 SUMOylates MDC1	yes	reactome/R-HSA-5684052.md	PIAS4 SUMOylates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	29	R-HSA-5684071	RNF4 ubiquitinates MDC1	yes	reactome/R-HSA-5684071.md	RNF4 ubiquitinates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	30	R-HSA-5686685	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5686685.md	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	31	R-HSA-5691411	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	yes	reactome/R-HSA-5691411.md	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	32	R-HSA-5693551	Phosphorylation of BRCA1-A complex at multiple sites by ATM	yes	reactome/R-HSA-5693551.md	Phosphorylation of BRCA1-A complex at multiple sites by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS1	genes/human/ABRAXAS1/ABRAXAS1-ai-review.yaml	ABRAXAS1	Q6UWZ7	NCBITaxon:9606	Homo sapiens	33	R-HSA-69891	Phosphorylation and activation of CHEK2 by ATM	yes	reactome/R-HSA-69891.md	Phosphorylation and activation of CHEK2 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported Reactome-derived nuclear compartment annotation. The BRCA1-A complex events involving FAM175A/ABRAXAS1 are modeled at nuclear DNA double-strand breaks.
human	ABRAXAS2	genes/human/ABRAXAS2/ABRAXAS2-ai-review.yaml	ABRAXAS2	Q15018	NCBITaxon:9606	Homo sapiens	30	R-HSA-5691439	BRISC complex deubiquitinates NLRP3	yes	reactome/R-HSA-5691439.md	BRISC complex deubiquitinates NLRP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization is consistent with ABRAXAS2 as a major cytosolic BRISC scaffold.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	12	R-HSA-390247	Beta-oxidation of very long chain fatty acids	yes	reactome/R-HSA-390247.md	Beta-oxidation of very long chain fatty acids	Homo sapiens	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	involved_in	BP	false		ACCEPT	"Reactome (TAS) assignment to the peroxisomal (acyl-CoA-oxidase-initiated) branch of fatty acid beta-oxidation, via the ""Beta-oxidation of very long chain fatty acids"" pathway. This is the correct peroxisomal specialization of the beta-oxidation process, of which ACAA1 catalyzes the thiolase step."
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	13	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) assignment to alpha-linolenic acid (ALA, C18:3n-3) metabolism. ACAA1 participates in the peroxisomal beta-oxidation chain-shortening of the C24:6n-3 intermediate to DHA within n-3 PUFA metabolism derived from ALA.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	15	R-HSA-390250	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA	yes	reactome/R-HSA-390250.md	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA	Homo sapiens	GO:0003988	acetyl-CoA C-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of the 3-ketoacyl-CoA thiolase activity to the specific reaction 3-ketohexacosanoyl-CoA + CoA => tetracosanoyl-CoA + acetyl-CoA, an instance of the core thiolase step.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033232	PEX7 binds cargo proteins containing PTS2	yes	reactome/R-HSA-9033232.md	PEX7 binds cargo proteins containing PTS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) cytosol localization corresponding to the pre-import state, when PEX7 binds the PTS2-containing cytosolic cargo (thiolase) prior to translocation into peroxisomes.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	27	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) cytosol localization for the cytosolic cargo state prior to PEX5L:PEX7-mediated translocation into the peroxisomal matrix.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	28	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) peroxisomal-matrix localization, the compartment where the mature ACAA1 enzyme resides and functions after PTS2 cleavage.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome (TAS) extracellular-region localization from the neutrophil-degranulation pathway (""Exocytosis of specific granule lumen proteins""). ACAA1 has been detected in neutrophil granule proteomes, but as a peroxisomal-matrix beta-oxidation enzyme an extracellular localization is not a biologically meaningful site of action."
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) specific-granule-lumen localization from the neutrophil-degranulation pathway. Based on detection of ACAA1 in neutrophil granule proteomes rather than a functional role there.
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	32	R-HSA-2066788	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase	yes	reactome/R-HSA-2066788.md	Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) peroxisomal-matrix localization from the ""Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase"" reaction, i.e. the matrix compartment where ACAA1 acts."
human	ACAA1	genes/human/ACAA1/ACAA1-ai-review.yaml	ACAA1	P09110	NCBITaxon:9606	Homo sapiens	33	R-HSA-390250	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA	yes	reactome/R-HSA-390250.md	3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) peroxisomal-matrix localization associated with a specific VLCFA thiolase reaction.
human	ACAA2	genes/human/ACAA2/ACAA2-ai-review.yaml	ACAA2	P42765	NCBITaxon:9606	Homo sapiens	20	R-HSA-8874745	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH	yes	reactome/R-HSA-8874745.md	ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted localization to the mitochondrial matrix. This is the most precise and correct localization for ACAA2, a soluble matrix thiolase (distinct from the inner-membrane MTP thiolase HADHB). Accept as core localization.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	19	R-HSA-75105	Fatty acyl-CoA biosynthesis	yes	reactome/R-HSA-75105.md	Fatty acyl-CoA biosynthesis	Homo sapiens	GO:0046949	fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation placing ACC1 in fatty-acyl-CoA biosynthesis. ACC1 supplies the malonyl-CoA that fuels the fatty acid synthase pathway; this reflects pathway context rather than ACC1's direct product. Retained as a correct non-core process (the specific malonyl-CoA/fatty-acid biosynthesis terms are the core BP).
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	20	R-HSA-75851	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-75851.md	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0046949	fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation (duplicate of the fatty-acyl-CoA biosynthetic process annotation) from the ACC carboxylation reaction module. Pathway-context process retained as non-core.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	22	R-HSA-200555	Formation of Malonyl-CoA from Acetyl-CoA (liver)	yes	reactome/R-HSA-200555.md	Formation of Malonyl-CoA from Acetyl-CoA (liver)	Homo sapiens	GO:0003989	acetyl-CoA carboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation to the enzyme's core catalytic activity (malonyl-CoA formation in liver). Correct core molecular function.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	23	R-HSA-75851	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-75851.md	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0003989	acetyl-CoA carboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation to acetyl-CoA carboxylase activity (biotinylated ACACA polymer carboxylating acetyl-CoA to malonyl-CoA). Correct core molecular function; redundant with the experimental IDA annotations.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	30	R-HSA-200555	Formation of Malonyl-CoA from Acetyl-CoA (liver)	yes	reactome/R-HSA-200555.md	Formation of Malonyl-CoA from Acetyl-CoA (liver)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol, consistent with the experimental (IDA) and curated localization of ACC1. Correct core localization.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	31	R-HSA-2993814	HLCS biotinylates ACACA:Mn2+	yes	reactome/R-HSA-2993814.md	HLCS biotinylates ACACA:Mn2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from the HLCS-biotinylates-ACACA module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	32	R-HSA-3065958	An unknown protease degrades ACACA	yes	reactome/R-HSA-3065958.md	An unknown protease degrades ACACA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from an ACACA degradation module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	33	R-HSA-75851	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-75851.md	Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from the ACC carboxylation reaction module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	34	R-HSA-163743	Transcriptional activation of ACACA by ChREBP:MLX	yes	reactome/R-HSA-163743.md	Transcriptional activation of ACACA by ChREBP:MLX	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from an ACACA transcriptional-activation module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	35	R-HSA-1655845	Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)	yes	reactome/R-HSA-1655845.md	Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from an ACACA expression module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACA	genes/human/ACACA/ACACA-ai-review.yaml	ACACA	Q13085	NCBITaxon:9606	Homo sapiens	36	R-HSA-3323184	Defective HLCS does not biotinylate ACACA:Mn2+	yes	reactome/R-HSA-3323184.md	Defective HLCS does not biotinylate ACACA:Mn2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol (from a defective-HLCS biotinylation module). Correct core localization, redundant with the experimental IDA annotation.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	36	R-HSA-8876889	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-8876889.md	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0055089	fatty acid homeostasis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS to fatty acid homeostasis, from the pathway in which biotinylated ACC2 carboxylates acetyl-CoA to malonyl-CoA. Consistent with ACC2's role in balancing fatty-acid synthesis and oxidation. Keep as non-core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	37	R-HSA-8876889	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-8876889.md	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0003989	acetyl-CoA carboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS to the core acetyl-CoA carboxylase activity, from the reaction in which the biotinylated ACACB polymer carboxylates acetyl-CoA to malonyl-CoA. Correct core function. Accept.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	40	R-HSA-200423	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis	yes	reactome/R-HSA-200423.md	pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing ACC2 to the mitochondrial outer membrane (reaction where pAMPK inactivates ACACB). This is ACC2's defining, physiologically critical location. Accept as core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	46	R-HSA-4167501	An unknown protease degrades ACACB	yes	reactome/R-HSA-4167501.md	An unknown protease degrades ACACB	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to mitochondrial outer membrane (ACACB degradation reaction). ACC2's defining location. Accept as core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	47	R-HSA-4167511	HLCS biotinylates ACACB	yes	reactome/R-HSA-4167511.md	HLCS biotinylates ACACB	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to mitochondrial outer membrane (HLCS biotinylates ACACB reaction). ACC2's defining location. Accept as core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	48	R-HSA-8876889	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	yes	reactome/R-HSA-8876889.md	Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to mitochondrial outer membrane (Btn-ACACB polymer carboxylates Ac-CoA reaction). ACC2's defining location. Accept as core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	49	R-HSA-1655830	Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)	yes	reactome/R-HSA-1655830.md	Expression of Acetyl CoA Carboxylase 2 (ACACB, ACC2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS to cytosol, from the ACACB expression reaction. This reflects the transcription/expression context rather than a functional cytosolic pool; ACC2 is targeted to the mitochondrial outer membrane. Keep as non-core.
human	ACACB	genes/human/ACACB/ACACB-ai-review.yaml	ACACB	O00763	NCBITaxon:9606	Homo sapiens	50	R-HSA-9856605	Transcriptional activation of ACACB by ChREBP:MLX	yes	reactome/R-HSA-9856605.md	Transcriptional activation of ACACB by ChREBP:MLX	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS to cytosol, from the ChREBP:MLX transcriptional-activation reaction. As with the other cytosol annotation, this reflects an expression/regulation context, not ACC2's functional mitochondrial-outer-membrane localization. Keep as non-core.
human	ACAD8	genes/human/ACAD8/ACAD8-ai-review.yaml	ACAD8	Q9UKU7	NCBITaxon:9606	Homo sapiens	17	R-HSA-70859	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2	yes	reactome/R-HSA-70859.md	isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the core functional location of ACAD8.
human	ACAD8	genes/human/ACAD8/ACAD8-ai-review.yaml	ACAD8	Q9UKU7	NCBITaxon:9606	Homo sapiens	18	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the core functional location of ACAD8.
human	ACAD8	genes/human/ACAD8/ACAD8-ai-review.yaml	ACAD8	Q9UKU7	NCBITaxon:9606	Homo sapiens	19	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the core functional location of ACAD8.
human	ACAD8	genes/human/ACAD8/ACAD8-ai-review.yaml	ACAD8	Q9UKU7	NCBITaxon:9606	Homo sapiens	20	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the core functional location of ACAD8.
human	ACAD8	genes/human/ACAD8/ACAD8-ai-review.yaml	ACAD8	Q9UKU7	NCBITaxon:9606	Homo sapiens	21	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the core functional location of ACAD8.
human	ACAD9	genes/human/ACAD9/ACAD9-ai-review.yaml	ACAD9	Q9H845	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex"". ACAD9 functions at the mitochondrial inner membrane as part of the MCIA complex during CI biogenesis."
human	ACAD9	genes/human/ACAD9/ACAD9-ai-review.yaml	ACAD9	Q9H845	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I"". Consistent with ACAD9's role as an MCIA assembly factor at the inner membrane."
human	ACAD9	genes/human/ACAD9/ACAD9-ai-review.yaml	ACAD9	Q9H845	NCBITaxon:9606	Homo sapiens	32	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""ND4, ND5 bind the 550kDa complex to form the 815kDa complex"". Another step in CI biogenesis at the inner membrane."
human	ACAD9	genes/human/ACAD9/ACAD9-ai-review.yaml	ACAD9	Q9H845	NCBITaxon:9606	Homo sapiens	33	R-HSA-6799199	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex	yes	reactome/R-HSA-6799199.md	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex"". This step directly involves the MCIA complex of which ACAD9 is a core member."
human	ACAD9	genes/human/ACAD9/ACAD9-ai-review.yaml	ACAD9	Q9H845	NCBITaxon:9606	Homo sapiens	34	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex"". Another CI assembly step at the inner membrane."
human	ACADM	genes/human/ACADM/ACADM-ai-review.yaml	ACADM	P11310	NCBITaxon:9606	Homo sapiens	30	R-HSA-109341	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA	yes	reactome/R-HSA-109341.md	dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome unsaturated medium-chain substrate reaction places ACADM in the mitochondrial matrix.
human	ACADM	genes/human/ACADM/ACADM-ai-review.yaml	ACADM	P11310	NCBITaxon:9606	Homo sapiens	31	R-HSA-1989745	Expression of ACADM	yes	reactome/R-HSA-1989745.md	Expression of ACADM	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome expression event carries the location of the produced ACADM protein.
human	ACADM	genes/human/ACADM/ACADM-ai-review.yaml	ACADM	P11310	NCBITaxon:9606	Homo sapiens	32	R-HSA-77338	Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2	yes	reactome/R-HSA-77338.md	Octanoyl-CoA+FAD => trans-Oct-2-enoyl-CoA+FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome describes the matrix dehydrogenation of octanoyl-CoA by ACADM.
human	ACADM	genes/human/ACADM/ACADM-ai-review.yaml	ACADM	P11310	NCBITaxon:9606	Homo sapiens	33	R-HSA-77345	Decanoyl-CoA+FAD => trans-Dec-2-enoyl-CoA+FADH2	yes	reactome/R-HSA-77345.md	Decanoyl-CoA+FAD => trans-Dec-2-enoyl-CoA+FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome describes the matrix dehydrogenation of decanoyl-CoA by ACADM.
human	ACADS	genes/human/ACADS/ACADS-ai-review.yaml	ACADS	P16219	NCBITaxon:9606	Homo sapiens	25	R-HSA-77319	Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2	yes	reactome/R-HSA-77319.md	Butanoyl-CoA+FAD => Crotonoyl-CoA+FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome locates ACADS-catalyzed butanoyl-CoA dehydrogenation in the mitochondrial matrix.
human	ACADS	genes/human/ACADS/ACADS-ai-review.yaml	ACADS	P16219	NCBITaxon:9606	Homo sapiens	26	R-HSA-77327	Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2	yes	reactome/R-HSA-77327.md	Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome locates ACADS-catalyzed hexanoyl-CoA dehydrogenation in the mitochondrial matrix.
human	ACADSB	genes/human/ACADSB/ACADSB-ai-review.yaml	ACADSB	P45954	NCBITaxon:9606	Homo sapiens	25	R-HSA-70800	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2	yes	reactome/R-HSA-70800.md	alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-70800 places the ACADSB-catalyzed 2-methylbutyryl-CoA to tiglyl-CoA reaction in the mitochondrial matrix.
human	ACADSB	genes/human/ACADSB/ACADSB-ai-review.yaml	ACADSB	P45954	NCBITaxon:9606	Homo sapiens	26	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome LONP1 degradation event supplies a mitochondrial-matrix location annotation, consistent with the independently established ACADSB compartment.
human	ACADSB	genes/human/ACADSB/ACADSB-ai-review.yaml	ACADSB	P45954	NCBITaxon:9606	Homo sapiens	27	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome LONP1 binding event supplies a mitochondrial-matrix annotation, matching the enzyme compartment recorded in human UniProt.
human	ACADVL	genes/human/ACADVL/ACADVL-ai-review.yaml	ACADVL	P49748	NCBITaxon:9606	Homo sapiens	32	R-HSA-1791069	Expression of ACADVL	yes	reactome/R-HSA-1791069.md	Expression of ACADVL	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome event describes ACADVL expression, not a beta-oxidation reaction.
human	ACADVL	genes/human/ACADVL/ACADVL-ai-review.yaml	ACADVL	P49748	NCBITaxon:9606	Homo sapiens	33	R-HSA-77299	palmitoyl-CoA+FAD => trans-Hexadec-2-enoyl-CoA+FADH2	yes	reactome/R-HSA-77299.md	palmitoyl-CoA+FAD => trans-Hexadec-2-enoyl-CoA+FADH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the palmitoyl-CoA dehydrogenation reaction in the mitochondrial matrix.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	12	R-HSA-2046180	KSPG is secreted from the cell	no				GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Reactome R-HSA-2046180 explicitly describes secretion of keratan sulfate proteoglycans into the extracellular matrix. Although the exported compartment is extracellular region, the source narrative resolves the destination as matrix.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	13	R-HSA-2046239	Extracellular KSPG translocates to the lysosome for degradation	no				GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome R-HSA-2046239 represents an extracellular keratan sulfate proteoglycan pool before lysosomal delivery. Its input is labeled extracellular region, and the narrative leaves uptake uncertain, including endocytosis or autophagy. Unlike the matrix-assembly and ECM-secretion records, this record does not specify whether the material entering turnover remains matrix-associated.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	14	R-HSA-2318623	Aggrecan binds Hyaluronan and HAPLN1	no				GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Reactome R-HSA-2318623 represents aggrecan binding hyaluronan and HAPLN1 into an extracellular matrix aggregate. Extracellular matrix is the informative location of this core binding event.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	15	R-HSA-2424246	Tenascins C, R, (X, N) bind lecticans	yes	reactome/R-HSA-2424246.md	Tenascins C, R, (X, N) bind lecticans	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Reactome R-HSA-2424246 represents tenascin binding to lecticans, including aggrecan. Its source summary explicitly identifies TNC and TNR as aggrecan partners in the extracellular matrix; the human G3 binding studies independently support this interaction.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	16	R-HSA-2424252	COMP binds collagen, fibronectin, aggrecan and matrilins	yes	reactome/R-HSA-2424252.md	COMP binds collagen, fibronectin, aggrecan and matrilins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Reactome R-HSA-2424252 represents COMP binding to aggrecan within the extracellular matrix. The aggrecan-COMP interaction is directly supported by PMID:17588949 and implicates aggrecan glycosaminoglycan chains.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	17	R-HSA-8855825	HTRA1 hydrolyzes ACAN (Aggrecan)	no				GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Reactome R-HSA-8855825 places HTRA1-mediated aggrecan cleavage within degradation of the extracellular matrix and explicitly describes that matrix-turnover role. The source therefore supports extracellular matrix as the more precise compartment of the represented cleavage event.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	18	R-HSA-2025724	B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Biosynthetic transit compartment, one of fourteen identical Golgi lumen rows. This row comes from the reaction in which B3GNT enzymes add GlcNAc to build the keratan chain on the aggrecan core protein. Correct, but it records where aggrecan is glycanated, not where it acts.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	19	R-HSA-2046175	CHST1 transfers sulfate to Gal on keratan chain	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from CHST1 sulfating galactose on the keratan chain. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	20	R-HSA-2046180	KSPG is secreted from the cell	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from the secretion step of keratan sulfate proteoglycan. The same Reactome reaction also generates one of the six extracellular region rows, which is how a single secretion event yields two GOA compartment statements.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	21	R-HSA-2046222	CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from CHST2/3/5/6 sulfating GlcNAc on the keratan chain. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	22	R-HSA-2046265	B4GALTs transfer Gal to the keratan chain	yes	reactome/R-HSA-2046265.md	B4GALTs transfer Gal to the keratan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from B4GALT enzymes transferring galactose to the keratan chain. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	23	R-HSA-2046285	ST3GAL1-4,6 optionally cap keratan chain	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from ST3GAL enzymes optionally capping the keratan chain with sialic acid. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	24	R-HSA-2046298	B4GALTs transfer Gal to a branch of keratan	yes	reactome/R-HSA-2046298.md	B4GALTs transfer Gal to a branch of keratan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from B4GALT enzymes transferring galactose to a keratan branch. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	25	R-HSA-3656230	Defective B4GALT1 does not transfer Gal to the keratan chain	yes	reactome/R-HSA-3656230.md	Defective B4GALT1 does not transfer Gal to the keratan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models defective B4GALT1 and failure of galactose transfer to a keratan chain in the Golgi. Aggrecan is represented among the proteoglycan acceptors. This places the proteoglycan acceptor in the Golgi during biosynthesis; retain that non-core location. The named modifying enzyme is the catalyst.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	26	R-HSA-3656258	Defective ST3GAL3 does not transfer SA to keratan	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models defective ST3GAL3 and failure of sialic acid transfer to keratan in the Golgi. Aggrecan is represented among the proteoglycan acceptors. This places the proteoglycan acceptor in the Golgi during biosynthesis; retain that non-core location. The named modifying enzyme is the catalyst.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	27	R-HSA-3656269	Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG	no				GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models defective CHST6 and failure of GlcNAc sulfation on keratan in the Golgi. Aggrecan is represented among the proteoglycan acceptors. This places the proteoglycan acceptor in the Golgi during biosynthesis; retain that non-core location. The named modifying enzyme is the catalyst.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	28	R-HSA-9035950	Defective B4GALT1 does not transfer Gal to a branch of keratan	yes	reactome/R-HSA-9035950.md	Defective B4GALT1 does not transfer Gal to a branch of keratan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models defective B4GALT1 and failure of galactose transfer to a keratan branch in the Golgi. Aggrecan is represented among the proteoglycan acceptors. This places the proteoglycan acceptor in the Golgi during biosynthesis; retain that non-core location. The named modifying enzyme is the catalyst.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	29	R-HSA-1793217	Unknown endo-β-galactosidase cleaves keratan chain	no				GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Catabolic compartment, from the reaction in which an unidentified endo-beta-galactosidase cleaves the keratan chain inside the lysosome. Correct as the site where aggrecan is degraded, not a functional location.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	30	R-HSA-2046239	Extracellular KSPG translocates to the lysosome for degradation	no				GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate lysosomal lumen row, from the translocation of extracellular keratan sulfate proteoglycan to the lysosome for degradation. The same Reactome reaction also generates one of the six extracellular region rows.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	35	R-HSA-2025723	B4GALTs transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-2025723.md	B4GALTs transfer Gal to the N-glycan precursor	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen row, from B4GALT enzymes transferring galactose to the N-glycan precursor that keratan chains are built on. Biosynthetic transit, not a site of function.
human	ACAN	genes/human/ACAN/ACAN-ai-review.yaml	ACAN	P16112	NCBITaxon:9606	Homo sapiens	36	R-HSA-9035949	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-9035949.md	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models defective B4GALT1 and failure of galactose transfer to the N-glycan precursor in the Golgi. Aggrecan is represented among the proteoglycan acceptors. This places the proteoglycan acceptor in the Golgi during biosynthesis; retain that non-core location. The named modifying enzyme is the catalyst.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	25	R-HSA-70844	alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA	yes	reactome/R-HSA-70844.md	alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	This Reactome isoleucine-intermediate cleavage reaction places the ACAT1 enzyme in the mitochondrial matrix.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	26	R-HSA-73916	2 acetyl-CoA <=> acetoacetyl-CoA + CoA	yes	reactome/R-HSA-73916.md	2 acetyl-CoA <=> acetoacetyl-CoA + CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	This Reactome acetyl-CoA condensation in ketogenesis reaction places the ACAT1 enzyme in the mitochondrial matrix.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	27	R-HSA-74181	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA	yes	reactome/R-HSA-74181.md	acetoacetyl-CoA + CoA <=> 2 acetyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	This Reactome acetoacetyl-CoA thiolysis in ketolysis reaction places the ACAT1 enzyme in the mitochondrial matrix.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	28	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome quality-control event includes a mitochondrial-matrix localization assertion for ACAT1.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	29	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome quality-control event includes a mitochondrial-matrix localization assertion for ACAT1.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	30	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome quality-control event includes a mitochondrial-matrix localization assertion for ACAT1.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	31	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome quality-control event includes a mitochondrial-matrix localization assertion for ACAT1.
human	ACAT1	genes/human/ACAT1/ACAT1-ai-review.yaml	ACAT1	P24752	NCBITaxon:9606	Homo sapiens	32	R-HSA-9854415	ACAT1 tetramer acetylates IDH2 dimer	yes	reactome/R-HSA-9854415.md	ACAT1 tetramer acetylates IDH2 dimer	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the ACAT1 tetramer in the mitochondrial matrix in an IDH2 acetylation event.
human	ACBD3	genes/human/ACBD3/ACBD3-ai-review.yaml	ACBD3	Q9H3P7	NCBITaxon:9606	Homo sapiens	21	R-HSA-8874979	ACBD3 binds GOLGB1	yes	reactome/R-HSA-8874979.md	ACBD3 binds GOLGB1	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane. This is the protein's defining compartment: ACBD3 is a peripheral Golgi-membrane scaffold, targeted there in two steps - an SCFD1-dependent step upstream, then redundant binding of the golgins giantin and golgin-45 to an MWT374-376 motif in the unique region just upstream of the GOLD domain (PMID:38134218) - and it is where it recruits PI4KB and anchors PKA. Core location. From a Reactome reaction. Correct compartment, asserted at pathway level.
human	ACER1	genes/human/ACER1/ACER1-ai-review.yaml	ACER1	Q8TDN7	NCBITaxon:9606	Homo sapiens	13	R-HSA-9845614	Sphingolipid catabolism	yes	reactome/R-HSA-9845614.md	Sphingolipid catabolism	Homo sapiens	GO:0030149	sphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places ACER1 in sphingolipid catabolism. Correct but a broad parent of the specific ceramide catabolic process that is the core BP; kept as non-core.
human	ACER1	genes/human/ACER1/ACER1-ai-review.yaml	ACER1	Q8TDN7	NCBITaxon:9606	Homo sapiens	15	R-HSA-428231	ACER1 hydrolyzes ceramide (endoplasmic reticulum)	yes	reactome/R-HSA-428231.md	ACER1 hydrolyzes ceramide (endoplasmic reticulum)	Homo sapiens	GO:0017040	N-acylsphingosine amidohydrolase activity	TAS	enables	MF	false		ACCEPT	Reactome (traceable author statement) of the core ceramidase activity of ACER1 at the ER membrane. Correct and consistent with experimental evidence.
human	ACER1	genes/human/ACER1/ACER1-ai-review.yaml	ACER1	Q8TDN7	NCBITaxon:9606	Homo sapiens	20	R-HSA-428231	ACER1 hydrolyzes ceramide (endoplasmic reticulum)	yes	reactome/R-HSA-428231.md	ACER1 hydrolyzes ceramide (endoplasmic reticulum)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable statement of ER membrane localization, matching the experimental EXP annotation; core cellular location.
human	ACER2	genes/human/ACER2/ACER2-ai-review.yaml	ACER2	Q5QJU3	NCBITaxon:9606	Homo sapiens	10	R-HSA-9845614	Sphingolipid catabolism	yes	reactome/R-HSA-9845614.md	Sphingolipid catabolism	Homo sapiens	GO:0030149	sphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing ACER2 in sphingolipid catabolism. Correct but a broad parent of the specific ceramide-catabolic core term; kept as non-core.
human	ACER2	genes/human/ACER2/ACER2-ai-review.yaml	ACER2	Q5QJU3	NCBITaxon:9606	Homo sapiens	12	R-HSA-428205	ACER2 hydrolyzes ceramide (Golgi)	yes	reactome/R-HSA-428205.md	ACER2 hydrolyzes ceramide (Golgi)	Homo sapiens	GO:0017040	N-acylsphingosine amidohydrolase activity	TAS	enables	MF	false		ACCEPT	Reactome curated reaction 'ACER2 hydrolyzes ceramide (Golgi)' asserting the core ceramidase activity. Correct.
human	ACER2	genes/human/ACER2/ACER2-ai-review.yaml	ACER2	Q5QJU3	NCBITaxon:9606	Homo sapiens	26	R-HSA-428205	ACER2 hydrolyzes ceramide (Golgi)	yes	reactome/R-HSA-428205.md	ACER2 hydrolyzes ceramide (Golgi)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome curated Golgi membrane localization for the ACER2 ceramide-hydrolysis reaction. Correct core location.
human	ACER3	genes/human/ACER3/ACER3-ai-review.yaml	ACER3	Q9NUN7	NCBITaxon:9606	Homo sapiens	27	R-HSA-428262	ACER3 hydrolyzes phytoceramide	yes	reactome/R-HSA-428262.md	ACER3 hydrolyzes phytoceramide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER-membrane location for the ACER3 phytoceramide-hydrolysis reaction; consistent with direct data.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	22	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	23	R-HSA-9770141	Formation of the Spliceosomal C* complex	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	24	R-HSA-9770142	Formation of the Spliceosomal B complex	yes	reactome/R-HSA-9770142.md	Formation of the Spliceosomal B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	25	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	26	R-HSA-9770236	Formation of the Spliceosomal P complex and exon ligation	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	27	R-HSA-9770847	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	28	R-HSA-9794542	Formation of the Spliceosomal C complex containing intron lariat	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported ACIN1 nuclear localization.
human	ACIN1	genes/human/ACIN1/ACIN1-ai-review.yaml	ACIN1	Q9UKV3	NCBITaxon:9606	Homo sapiens	33	R-HSA-201630	Caspase-mediated cleavage of Acinus	yes	reactome/R-HSA-201630.md	Caspase-mediated cleavage of Acinus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Cytosol is not the supported core ACIN1 location.
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	24	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome (neutrophil-degranulation ""Exocytosis of azurophil granule lumen proteins"") localization to extracellular region. This reflects capture of an abundant cytosolic enzyme in a secretory/degranulation pathway rather than a site where ACLY performs its function. Not a functional location; over-annotation."
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	25	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome (neutrophil-degranulation ""Exocytosis of ficolin-rich granule lumen proteins"") localization to extracellular region. As above, this is a degranulation-pathway capture of a cytosolic enzyme, not a functional location. Over-annotation."
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	26	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation annotation placing ACLY in the azurophil granule lumen. ACLY is a cytosolic enzyme; its appearance in granule/degranulation proteomics does not indicate function in this compartment. Over-annotation.
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	27	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation annotation placing ACLY in the ficolin-1-rich granule lumen. Same rationale as the azurophil granule annotation: a degranulation-pathway capture of a cytosolic enzyme, not a functional location. Over-annotation.
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	41	R-HSA-163770	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX	yes	reactome/R-HSA-163770.md	Transcriptional activation of Citrate lyase monomer gene by ChREBP:MLX	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol (transcriptional-activation pathway context). Consistent with the established primary location of ACLY. Correct core CC.
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	42	R-HSA-75848	ACLY tetramer transforms CIT to Ac-CoA	yes	reactome/R-HSA-75848.md	ACLY tetramer transforms CIT to Ac-CoA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to cytosol (""ACLY tetramer transforms CIT to Ac-CoA""). This is the compartment in which ACLY performs its catalytic function. Correct core CC."
human	ACLY	genes/human/ACLY/ACLY-ai-review.yaml	ACLY	P53396	NCBITaxon:9606	Homo sapiens	43	R-HSA-9734540	ACLY tetramer binds ETC-1002-CoA	yes	reactome/R-HSA-9734540.md	ACLY tetramer binds ETC-1002-CoA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to cytosol (""ACLY tetramer binds ETC-1002-CoA"", the bempedoic acid active metabolite). Correct primary location of ACLY. Accept."
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	28	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome represents a transient cytosolic pre-import pool.
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	29	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The docking reaction represents cargo before matrix entry.
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	30	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	The matrix is the destination and catalytic compartment of ACOX1.
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	33	R-HSA-1989749	Expression of ACOX1	yes	reactome/R-HSA-1989749.md	Expression of ACOX1	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Retain the matrix location in the ACOX1 expression event.
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	34	R-HSA-2066787	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA	yes	reactome/R-HSA-2066787.md	Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Retain the peroxisomal matrix location of the DHA precursor oxidation step.
human	ACOX1	genes/human/ACOX1/ACOX1-ai-review.yaml	ACOX1	Q15067	NCBITaxon:9606	Homo sapiens	35	R-HSA-390256	ACOX1 oxidizes C26:0 CoA	yes	reactome/R-HSA-390256.md	ACOX1 oxidizes C26:0 CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Retain the matrix location of C26:0-CoA oxidation.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	25	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ACOX2 can occupy the cytosol as a PEX5 cargo before peroxisomal import.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ACOX2 can occupy the cytosol as a PEX5 cargo before peroxisomal import.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	35	R-HSA-192335	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)	yes	reactome/R-HSA-192335.md	25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix localization from Reactome, tied to the curated reaction in which ACOX2 dehydrogenates 25(S) THCA-CoA in the peroxisomal matrix. Accurate compartment for this soluble matrix enzyme.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	36	R-HSA-193369	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA	yes	reactome/R-HSA-193369.md	25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix localization from Reactome, tied to the curated reaction in which ACOX2 dehydrogenates 25(S) DHCA-CoA. Accurate compartment for this soluble matrix enzyme.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	37	R-HSA-389889	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA	yes	reactome/R-HSA-389889.md	ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix localization from Reactome, tied to the curated reaction in which ACOX2:FAD oxidizes (2S)-pristanoyl-CoA. Accurate compartment for this soluble matrix enzyme.
human	ACOX2	genes/human/ACOX2/ACOX2-ai-review.yaml	ACOX2	Q99424	NCBITaxon:9606	Homo sapiens	38	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix localization from Reactome, from the peroxisomal-import reaction in which PEX5 cargo (including ACOX2) is translocated into the matrix. Accurate destination compartment.
human	ACOX3	genes/human/ACOX3/ACOX3-ai-review.yaml	ACOX3	O15254	NCBITaxon:9606	Homo sapiens	21	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation reflecting the transient cytosolic stage of PEX5-mediated peroxisomal matrix import (cargo translocates from the cytosol to the peroxisomal matrix), not a steady-state cytosolic localization. Keep as non-core; the steady-state compartment is the peroxisomal matrix.
human	ACOX3	genes/human/ACOX3/ACOX3-ai-review.yaml	ACOX3	O15254	NCBITaxon:9606	Homo sapiens	22	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome cytosol annotation from the PEX5 docking/translocation step. As above, an import intermediate rather than the functional localization.
human	ACOX3	genes/human/ACOX3/ACOX3-ai-review.yaml	ACOX3	O15254	NCBITaxon:9606	Homo sapiens	24	R-HSA-389891	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)	yes	reactome/R-HSA-389891.md	(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Correct, specific localization. Reactome models ACOX3 as the matrix enzyme catalyzing (2S)-pristanoyl-CoA oxidation. Consistent with the PTS1 import pathway and UniProt peroxisome localization.
human	ACOX3	genes/human/ACOX3/ACOX3-ai-review.yaml	ACOX3	O15254	NCBITaxon:9606	Homo sapiens	25	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Duplicate peroxisomal-matrix annotation from the PEX5 import reaction (cargo released into the peroxisomal matrix). Correct steady-state localization.
human	ACSL4	genes/human/ACSL4/ACSL4-ai-review.yaml	ACSL4	O60488	NCBITaxon:9606	Homo sapiens	20	R-HSA-434313	Intracellular metabolism of fatty acids regulates insulin secretion	yes	reactome/R-HSA-434313.md	Intracellular metabolism of fatty acids regulates insulin secretion	Homo sapiens	GO:0006631	fatty acid metabolic process	TAS	involved_in	BP	false		ACCEPT	The insulin-secretion pathway includes a direct fatty-acid metabolism step catalyzed by ACSL4.
human	ACSL4	genes/human/ACSL4/ACSL4-ai-review.yaml	ACSL4	O60488	NCBITaxon:9606	Homo sapiens	21	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		ACCEPT	ACSL4 directly synthesizes long-chain fatty acyl-CoAs by fatty-acid activation.
human	ACSL4	genes/human/ACSL4/ACSL4-ai-review.yaml	ACSL4	O60488	NCBITaxon:9606	Homo sapiens	22	R-HSA-434382	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A	yes	reactome/R-HSA-434382.md	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A	Homo sapiens	GO:0090433	palmitoyl-CoA ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Palmitate activation is a reported secondary substrate activity.
human	ACSL4	genes/human/ACSL4/ACSL4-ai-review.yaml	ACSL4	O60488	NCBITaxon:9606	Homo sapiens	23	R-HSA-434382	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A	yes	reactome/R-HSA-434382.md	ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome locates the beta-cell ACSL3/4 activation reaction at the mitochondrial outer membrane.
human	ACSL4	genes/human/ACSL4/ACSL4-ai-review.yaml	ACSL4	O60488	NCBITaxon:9606	Homo sapiens	24	R-HSA-548843	ACSL3,4 ligate CoA to AA to form AA-CoA	yes	reactome/R-HSA-548843.md	ACSL3,4 ligate CoA to AA to form AA-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The arachidonate activation reaction occurs at ER-associated ACSL4.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	31	R-HSA-390593	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-390593.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	32	R-HSA-390595	Calcium Binds Troponin-C	yes	reactome/R-HSA-390595.md	Calcium Binds Troponin-C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	33	R-HSA-390597	Release Of ADP From Myosin	yes	reactome/R-HSA-390597.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	34	R-HSA-390598	Myosin Binds ATP	yes	reactome/R-HSA-390598.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	35	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	36	R-HSA-9934294	CDH1-associated CTNNA1 binds VCL	yes	reactome/R-HSA-9934294.md	CDH1-associated CTNNA1 binds VCL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	37	R-HSA-9934410	CDH1 forms homotypic trans-dimers	yes	reactome/R-HSA-9934410.md	CDH1 forms homotypic trans-dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA1	genes/human/ACTA1/ACTA1-ai-review.yaml	ACTA1	P68133	NCBITaxon:9606	Homo sapiens	38	R-HSA-9934486	CDH1-associated CTNNA1 binds F-actin	yes	reactome/R-HSA-9934486.md	CDH1-associated CTNNA1 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment of ACTA1 actin assembly and contractile function.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	27	R-HSA-445699	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-445699.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	28	R-HSA-445700	Myosin Binds ATP	yes	reactome/R-HSA-445700.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	29	R-HSA-445704	Calcium Binds Caldesmon	yes	reactome/R-HSA-445704.md	Calcium Binds Caldesmon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	30	R-HSA-445705	Release Of ADP From Myosin	yes	reactome/R-HSA-445705.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	31	R-HSA-9604664	ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4	yes	reactome/R-HSA-9604664.md	ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	32	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	33	R-HSA-9934294	CDH1-associated CTNNA1 binds VCL	yes	reactome/R-HSA-9934294.md	CDH1-associated CTNNA1 binds VCL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	34	R-HSA-9934410	CDH1 forms homotypic trans-dimers	yes	reactome/R-HSA-9934410.md	CDH1 forms homotypic trans-dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTA2	genes/human/ACTA2/ACTA2-ai-review.yaml	ACTA2	P62736	NCBITaxon:9606	Homo sapiens	35	R-HSA-9934486	CDH1-associated CTNNA1 binds F-actin	yes	reactome/R-HSA-9934486.md	CDH1-associated CTNNA1 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core compartment for ACTA2 monomers and contractile actin assemblies.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	125	R-HSA-5250947	B-WICH complex binds rDNA promoter	yes	reactome/R-HSA-5250947.md	B-WICH complex binds rDNA promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	126	R-HSA-5689544	UCHL5 binds INO80 complex	yes	reactome/R-HSA-5689544.md	UCHL5 binds INO80 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	127	R-HSA-9825847	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	yes	reactome/R-HSA-9825847.md	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	128	R-HSA-9933236	SS18-containing ATPase complex binds SMARCC dimer:SMARCDs:BICRAs:BRD9	yes	reactome/R-HSA-9933236.md	SS18-containing ATPase complex binds SMARCC dimer:SMARCDs:BICRAs:BRD9	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	129	R-HSA-9933237	PBRM1-containing ATPase complex binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD&:PHF10	yes	reactome/R-HSA-9933237.md	PBRM1-containing ATPase complex binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD&:PHF10	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	130	R-HSA-9933238	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	yes	reactome/R-HSA-9933238.md	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	131	R-HSA-9934021	Formation of neuronal progenitor BAF (npBAF)	yes	reactome/R-HSA-9934021.md	Formation of neuronal progenitor BAF (npBAF)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	132	R-HSA-9934024	SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10	yes	reactome/R-HSA-9934024.md	SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	133	R-NUL-4551334	NuA4 complex actetylates H2A and H4	yes	reactome/R-NUL-4551334.md	NuA4 complex actetylates H2A and H4	Gallus gallus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the nucleoplasm.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	134	R-HSA-1861595	Extension of pseudopodia by myosin-X in a PI3K dependent manner	yes	reactome/R-HSA-1861595.md	Extension of pseudopodia by myosin-X in a PI3K dependent manner	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	135	R-HSA-2029466	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	yes	reactome/R-HSA-2029466.md	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	136	R-HSA-2029473	Branching and elongation of mother and daughter filaments	yes	reactome/R-HSA-2029473.md	Branching and elongation of mother and daughter filaments	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	137	R-HSA-2029476	Role of myosins in phagosome formation	yes	reactome/R-HSA-2029476.md	Role of myosins in phagosome formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	138	R-HSA-203070	Association of profilin with monomeric actin	yes	reactome/R-HSA-203070.md	Association of profilin with monomeric actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	139	R-HSA-2197690	Detachment of WASP/WAVE	yes	reactome/R-HSA-2197690.md	Detachment of WASP/WAVE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	140	R-HSA-392751	L1 linked to actin cytoskeleton by ankyrin	yes	reactome/R-HSA-392751.md	L1 linked to actin cytoskeleton by ankyrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	141	R-HSA-3928595	N-WASP binds ARP2/3 and G-actin	yes	reactome/R-HSA-3928595.md	N-WASP binds ARP2/3 and G-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	142	R-HSA-430347	MigFilin associates with Filamin and F-actin	yes	reactome/R-HSA-430347.md	MigFilin associates with Filamin and F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	143	R-HSA-443779	Linkage of L1 with treadmilling F-actin	yes	reactome/R-HSA-443779.md	Linkage of L1 with treadmilling F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	144	R-HSA-445089	Dephosphorylation of pL1 (Y1176)	yes	reactome/R-HSA-445089.md	Dephosphorylation of pL1 (Y1176)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	145	R-HSA-5218916	p-MAPK2/3 phosphorylates HSP27	yes	reactome/R-HSA-5218916.md	p-MAPK2/3 phosphorylates HSP27	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	146	R-HSA-5626507	IQGAPs bind F-actin, which is inhibited by calmodulin	yes	reactome/R-HSA-5626507.md	IQGAPs bind F-actin, which is inhibited by calmodulin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	147	R-HSA-5665751	CDC42:GTP:FMNL2 binds Profilin:G-actin	yes	reactome/R-HSA-5665751.md	CDC42:GTP:FMNL2 binds Profilin:G-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	148	R-HSA-5665767	Activated FMNL3 binds G-actin	yes	reactome/R-HSA-5665767.md	Activated FMNL3 binds G-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	149	R-HSA-5665802	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin	yes	reactome/R-HSA-5665802.md	SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	150	R-HSA-5665809	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments	yes	reactome/R-HSA-5665809.md	SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	151	R-HSA-5665982	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1	yes	reactome/R-HSA-5665982.md	RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	152	R-HSA-5666001	Profilin:G-actin binds MKL1	yes	reactome/R-HSA-5666001.md	Profilin:G-actin binds MKL1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	153	R-HSA-9666458	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole	yes	reactome/R-HSA-9666458.md	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	154	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	155	R-HSA-9934294	CDH1-associated CTNNA1 binds VCL	yes	reactome/R-HSA-9934294.md	CDH1-associated CTNNA1 binds VCL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	156	R-HSA-9934410	CDH1 forms homotypic trans-dimers	yes	reactome/R-HSA-9934410.md	CDH1 forms homotypic trans-dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	157	R-HSA-9934486	CDH1-associated CTNNA1 binds F-actin	yes	reactome/R-HSA-9934486.md	CDH1-associated CTNNA1 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the cytosol.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	158	R-HSA-3928654	Clathrin internalises EPH:EFN complexes	yes	reactome/R-HSA-3928654.md	Clathrin internalises EPH:EFN complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	159	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	160	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	161	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	162	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	163	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	164	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	165	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	166	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	167	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	168	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTB	genes/human/ACTB/ACTB-ai-review.yaml	ACTB	P60709	NCBITaxon:9606	Homo sapiens	169	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated event places ACTB in the plasma membrane.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	20	R-HSA-445699	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-445699.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	First of eight identical GO:0005829 rows exported one per Reactome reaction (R-HSA-445699, -445700, -445704, -445705, -9914537, -9934294, -9934410, -9934486, spanning Smooth Muscle Contraction, Regulation of CDH1 Function and the dystrophin-glycoprotein complex). They are one curatorial claim - that ACTG2 participates in these reactions as a cytosolic entity - rendered eight times by the export, not eight independent findings, and the reasoning is given once here and cross-referenced on rows 21 to 27. The claim is true and, for this gene, more than usually meaningful. Actin exists in a monomer-polymer equilibrium, the monomeric G-actin pool is cytosolic, and that pool is the disease-relevant variable here: every characterised ACTG2 variant is assayed as a shift in the G-actin/F-actin ratio or in the critical concentration. It is nevertheless not the core location. ACTG2's function is discharged in the filament, in the contractile apparatus of visceral smooth muscle; cytosol is where the unpolymerised reserve sits.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	21	R-HSA-445700	Myosin Binds ATP	yes	reactome/R-HSA-445700.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Second of the eight per-reaction Reactome cytosol rows; see row 20 for the reasoning, which is identical and is not restated per reaction.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	22	R-HSA-445704	Calcium Binds Caldesmon	yes	reactome/R-HSA-445704.md	Calcium Binds Caldesmon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Third of the eight per-reaction Reactome cytosol rows; see row 20.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	23	R-HSA-445705	Release Of ADP From Myosin	yes	reactome/R-HSA-445705.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fourth of the eight per-reaction Reactome cytosol rows; see row 20.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	24	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fifth of the eight per-reaction Reactome cytosol rows; see row 20. This one belongs to the dystrophin-glycoprotein complex pathway rather than to smooth muscle contraction, but the compartment claim it exports is the same.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	25	R-HSA-9934294	CDH1-associated CTNNA1 binds VCL	yes	reactome/R-HSA-9934294.md	CDH1-associated CTNNA1 binds VCL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Sixth of the eight per-reaction Reactome cytosol rows; see row 20. From the Regulation of CDH1 Function pathway.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	26	R-HSA-9934410	CDH1 forms homotypic trans-dimers	yes	reactome/R-HSA-9934410.md	CDH1 forms homotypic trans-dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Seventh of the eight per-reaction Reactome cytosol rows; see row 20.
human	ACTG2	genes/human/ACTG2/ACTG2-ai-review.yaml	ACTG2	P63267	NCBITaxon:9606	Homo sapiens	27	R-HSA-9934486	CDH1-associated CTNNA1 binds F-actin	yes	reactome/R-HSA-9934486.md	CDH1-associated CTNNA1 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Eighth and last of the per-reaction Reactome cytosol rows; see row 20. This reaction is ""CDH1-associated CTNNA1 binds F-actin"", i.e. the one place in the export where ACTG2 is being used as filamentous rather than monomeric actin, which makes cytosol the least apt of the eight."
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	11	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places dynactin, and hence ACTR10, in the cytosol as a participant in transport of antigen-loaded MHC class II molecules to the cell surface. The compartment is correct: ACTR10 has no signal peptide, no transmembrane segment and no lipid anchor, and dynactin is a soluble cytoplasmic complex. This is the first of five rows carrying the same term from five different Reactome reactions.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	12	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol assignment, here from the reaction in which ERGIC-to-Golgi vesicles bind dynein:dynactin. Correct compartment for a soluble dynactin subunit; the reaction is a genuine dynactin function, but the only GO statement extracted from it is a location the gene already has.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	13	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol assignment, from the Golgi vesicle-tethering reaction. Correct compartment, no functional content for ACTR10.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	14	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol assignment, from the reaction in which RAB6:GTP displaces PAFAH1B1/LIS1 from the dynein:dynactin complex. Correct compartment, no functional content for ACTR10 specifically.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	15	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol assignment, from the reaction in which dynein drives COPI-independent Golgi-to-ER retrograde traffic. Notable as the clearest case where Reactome records a real dynactin-dependent process from which only a location term has reached GO for ACTR10.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	16	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	"Follows from ACTR10's inclusion in Reactome's azurophil granule lumen protein set, which Reactome's Neutrophil degranulation pathway derives from bulk neutrophil granule proteomics. ACTR10 has no signal peptide and no transmembrane segment - the UniProt feature table contains only a CHAIN, three sequence conflicts and secondary-structure features - and its only recorded location is ""Cytoplasm, cytoskeleton"". A subunit buried at the pointed end of a 1.2 MDa cytosolic complex has no route into the secretory pathway. The assignment is also not a property of dynactin, and this is now computed rather than asserted. Across the 11 canonical subunits named in UniProt's SUBUNIT line - DCTN1, DCTN2 and DCTN3 in the shoulder, ACTR1A and ACTB in the filament, CAPZA1 and CAPZB at the barbed end, ACTR10, DCTN4, DCTN5 and DCTN6 at the pointed end - exactly one, ACTR10, carries any annotation originating from Reactome's Neutrophil degranulation route, and ACTR10 alone is annotated to azurophil granule lumen. Two near-misses are worth stating because they would otherwise inflate the count: CAPZA1 does carry an extracellular-region TAS, but from R-HSA-879377, an S100B/AGER binding reaction that is not under Neutrophil degranulation at all; and ACTB carries extracellular-region terms only by HDA mass spectrometry, a different artefact class. The one protein that genuinely shares ACTR10's route is ACTR1B, the beta-centractin paralog that substitutes for ACTR1A in a fraction of dynactin and so is a twelfth protein rather than one of the 11 - and, like CAPZA1, one with a large non-dynactin pool. So the pattern is per-protein detection in granule fractions, not secretion of the complex."
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	17	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	Duplicate extracellular-region assignment, here from the ficolin-rich granule exocytosis reaction. The same argument applies: no signal peptide, no transmembrane segment, a single cytoplasmic UniProt location, and none of the other ten canonical dynactin subunits carries an annotation from this Reactome route (CAPZA1's extracellular TAS comes from an unrelated S100B/AGER reaction). Only ACTR1B, the beta-centractin paralog outside the canonical 11, shares it.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		REMOVE	The strongest form of the same error: ACTR10 is placed in the lumen of a secretory granule. Reaching a granule lumen requires translocation into the secretory pathway, for which ACTR10 has neither a signal peptide nor a transmembrane segment; and it would require dissociation from the dynactin complex, which ACTR10 is required to hold together. The annotation traces to bulk granule-fraction proteomics cited by Reactome's Neutrophil degranulation pathway.
human	ACTR10	genes/human/ACTR10/ACTR10-ai-review.yaml	ACTR10	Q9NZ32	NCBITaxon:9606	Homo sapiens	19	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		REMOVE	Same granule-lumen assignment for the ficolin-1-rich (specific) granule subset. Identical objection: no secretory-pathway targeting information in the sequence, a single cytoplasmic UniProt location, obligatory residence in a large cytosolic complex, and no canonical dynactin subunit shares the term - the only other dynactin-associated protein that carries it is ACTR1B, the beta-centractin paralog outside the canonical 11. ACTR1B and CAPZA1 are alike in having large non-dynactin pools, but only ACTR1B is on this Reactome route: CAPZA1's single extracellular-region TAS comes from an unrelated S100B/AGER reaction.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	10	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Transport of antigen loaded MHC II molecules to surface'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	11	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'AJUBA facilitates AURKA autophosphorylation'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	12	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'AJUBA binds centrosome-associated AURKA'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	13	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'AURKA phosphorylates PLK1'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	14	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'BORA binds PLK1 and AURKA'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	15	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Plk1-mediated phosphorylation of Nlp'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	16	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	17	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Loss of C-Nap-1 from centrosomes'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	18	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Dissociation of Phospho-Nlp from the centrosome'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	19	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Recruitment of Plk1 to centrosomes'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	20	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Association of NuMA with microtubules'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	21	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Recruitment of CDK11p58 to the centrosomes'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	22	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Translocation of NuMA to the centrosomes'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	23	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'RAB3IP stimulates nucleotide exchange on RAB8A'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	24	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'C2CD3 binds the mother centriole'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	25	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	26	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'CP110 and CEP97 dissociate from the centriole'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	27	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'The distal appendage proteins recruit TTBK2'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	28	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Recruitment of transition zone proteins'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	29	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'MARK4 binds ODF2 in the centriole'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	30	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	31	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'ERGIC-to-Golgi vesicles bind dynein:dynactin'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	32	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	33	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	34	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	35	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'TPX2 binds AURKA at centrosomes'. Correct but low-information, and one of 27 identical rows.
human	ACTR1A	genes/human/ACTR1A/ACTR1A-ai-review.yaml	ACTR1A	P61163	NCBITaxon:9606	Homo sapiens	36	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation asserted by Reactome for the dynactin complex as a participant in the reaction 'TPX2 promotes AURKA autophosphorylation'. Correct but low-information, and one of 27 identical rows.
human	ACTR1B	genes/human/ACTR1B/ACTR1B-ai-review.yaml	ACTR1B	P42025	NCBITaxon:9606	Homo sapiens	12	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	Topologically impossible for a cytosolic actin-fold protein. This extracellular region assertion comes from the Reactome Neutrophil degranulation pathway, where ACTR1B is modelled as a granule lumen protein released by exocytosis. The Reactome pathway model places ACTR1B among the neutrophil granule lumen proteins, membership that traces to granule subcellular-fraction proteomics (Reactome's own summation for these reactions cites Rorvig et al. 2009, 2013). ACTR1B has no signal peptide and no transmembrane segment -- the P42025 feature table contains only CHAIN, MOD_RES and VARIANT -- and UniProt places it in the cytoplasm and cytoskeleton only, with the founding paper finding no free pool outside dynactin. A cytosolic actin-fold protein cannot be topologically inside a granule lumen or secreted. The decisive argument is the paralog pair: ACTR1A is in the same complex at roughly fifteen times the abundance, so if beta-centractin were genuinely granule-lumen cargo alpha-centractin would necessarily be too, and ACTR1A carries none of these four Reactome annotations. The asymmetry is detection stochasticity in a granule proteome, not localisation. If the proteomic observation is worth recording at all, the honest representation is a granule-associated cytoplasmic-face location or the extracellular-vesicle row already on this record, not a lumen or extracellular term.
human	ACTR1B	genes/human/ACTR1B/ACTR1B-ai-review.yaml	ACTR1B	P42025	NCBITaxon:9606	Homo sapiens	13	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	Topologically impossible for a cytosolic actin-fold protein. This extracellular region assertion comes from the Reactome Neutrophil degranulation pathway, where ACTR1B is modelled as a granule lumen protein released by exocytosis. The Reactome pathway model places ACTR1B among the neutrophil granule lumen proteins, membership that traces to granule subcellular-fraction proteomics (Reactome's own summation for these reactions cites Rorvig et al. 2009, 2013). ACTR1B has no signal peptide and no transmembrane segment -- the P42025 feature table contains only CHAIN, MOD_RES and VARIANT -- and UniProt places it in the cytoplasm and cytoskeleton only, with the founding paper finding no free pool outside dynactin. A cytosolic actin-fold protein cannot be topologically inside a granule lumen or secreted. The decisive argument is the paralog pair: ACTR1A is in the same complex at roughly fifteen times the abundance, so if beta-centractin were genuinely granule-lumen cargo alpha-centractin would necessarily be too, and ACTR1A carries none of these four Reactome annotations. The asymmetry is detection stochasticity in a granule proteome, not localisation. If the proteomic observation is worth recording at all, the honest representation is a granule-associated cytoplasmic-face location or the extracellular-vesicle row already on this record, not a lumen or extracellular term.
human	ACTR1B	genes/human/ACTR1B/ACTR1B-ai-review.yaml	ACTR1B	P42025	NCBITaxon:9606	Homo sapiens	14	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		REMOVE	Topologically impossible for a cytosolic actin-fold protein. This secretory granule lumen assertion comes from the Reactome Neutrophil degranulation pathway, where ACTR1B is modelled as a granule lumen protein released by exocytosis. The Reactome pathway model places ACTR1B among the neutrophil granule lumen proteins, membership that traces to granule subcellular-fraction proteomics (Reactome's own summation for these reactions cites Rorvig et al. 2009, 2013). ACTR1B has no signal peptide and no transmembrane segment -- the P42025 feature table contains only CHAIN, MOD_RES and VARIANT -- and UniProt places it in the cytoplasm and cytoskeleton only, with the founding paper finding no free pool outside dynactin. A cytosolic actin-fold protein cannot be topologically inside a granule lumen or secreted. The decisive argument is the paralog pair: ACTR1A is in the same complex at roughly fifteen times the abundance, so if beta-centractin were genuinely granule-lumen cargo alpha-centractin would necessarily be too, and ACTR1A carries none of these four Reactome annotations. The asymmetry is detection stochasticity in a granule proteome, not localisation. If the proteomic observation is worth recording at all, the honest representation is a granule-associated cytoplasmic-face location or the extracellular-vesicle row already on this record, not a lumen or extracellular term.
human	ACTR1B	genes/human/ACTR1B/ACTR1B-ai-review.yaml	ACTR1B	P42025	NCBITaxon:9606	Homo sapiens	15	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		REMOVE	Topologically impossible for a cytosolic actin-fold protein. This ficolin-1-rich granule lumen assertion comes from the Reactome Neutrophil degranulation pathway, where ACTR1B is modelled as a granule lumen protein released by exocytosis. The Reactome pathway model places ACTR1B among the neutrophil granule lumen proteins, membership that traces to granule subcellular-fraction proteomics (Reactome's own summation for these reactions cites Rorvig et al. 2009, 2013). ACTR1B has no signal peptide and no transmembrane segment -- the P42025 feature table contains only CHAIN, MOD_RES and VARIANT -- and UniProt places it in the cytoplasm and cytoskeleton only, with the founding paper finding no free pool outside dynactin. A cytosolic actin-fold protein cannot be topologically inside a granule lumen or secreted. The decisive argument is the paralog pair: ACTR1A is in the same complex at roughly fifteen times the abundance, so if beta-centractin were genuinely granule-lumen cargo alpha-centractin would necessarily be too, and ACTR1A carries none of these four Reactome annotations. The asymmetry is detection stochasticity in a granule proteome, not localisation. If the proteomic observation is worth recording at all, the honest representation is a granule-associated cytoplasmic-face location or the extracellular-vesicle row already on this record, not a lumen or extracellular term.
human	ACTR1B	genes/human/ACTR1B/ACTR1B-ai-review.yaml	ACTR1B	P42025	NCBITaxon:9606	Homo sapiens	18	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct and well supported. Reactome places dynactin in the cytosol for the dynein-dependent transport of peptide-loaded MHC class II to the cell surface, and the founding beta-centractin paper found both centractin isoforms predominantly in the cytosolic fraction, entirely within the 20S dynactin complex, with no free pool. This is where ACTR1B does its work.
human	ACTR5	genes/human/ACTR5/ACTR5-ai-review.yaml	ACTR5	Q9H9F9	NCBITaxon:9606	Homo sapiens	33	R-HSA-5689544	UCHL5 binds INO80 complex	yes	reactome/R-HSA-5689544.md	UCHL5 binds INO80 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Correct and slightly more informative than nucleus: the Reactome reaction places the INO80 complex, and therefore ACTR5, in the nucleoplasm.
human	ACTR8	genes/human/ACTR8/ACTR8-ai-review.yaml	ACTR8	Q9H981	NCBITaxon:9606	Homo sapiens	28	R-HSA-5689544	UCHL5 binds INO80 complex	yes	reactome/R-HSA-5689544.md	UCHL5 binds INO80 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome's compartment assignment for the reaction UCHL5 binds INO80 complex. Correct but redundant with the HPA IDA.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	28	R-HSA-9748784	Drug ADME	yes	reactome/R-HSA-9748784.md	Drug ADME	Homo sapiens	GO:0006805	xenobiotic metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (Drug ADME) annotation reflecting ADA's deamination of nucleoside analog drugs, notably ribavirin (RBV -> RBV-COOH) and cordycepin. This is a pharmacologically important but incidental substrate promiscuity.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	29	R-HSA-74217	Purine salvage	yes	reactome/R-HSA-74217.md	Purine salvage	Homo sapiens	GO:0043101	purine-containing compound salvage	TAS	involved_in	BP	false		ACCEPT	Reactome (Purine salvage pathway) TAS annotation. ADA participates in the purine salvage/interconversion network by converting adenosine and 2'-deoxyadenosine to their inosine counterparts, which are then further metabolized.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	36	R-HSA-9754964	ADA deamidates RBV	yes	reactome/R-HSA-9754964.md	ADA deamidates RBV	Homo sapiens	GO:0019239	deaminase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome assigns generic deaminase activity to ribavirin deamidation.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	39	R-HSA-9734745	Defective ADA does not deaminate (deoxy)adenosine	yes	reactome/R-HSA-9734745.md	Defective ADA does not deaminate (deoxy)adenosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The disease reaction retains the cytosolic compartment of normal ADA.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	40	R-HSA-74241	ADA catalyzes the deamination of (deoxy)adenosine	yes	reactome/R-HSA-74241.md	ADA catalyzes the deamination of (deoxy)adenosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosolic localization (ADA catalyzes the deamination of (deoxy)adenosine). Consistent with the core cytosolic site of ADA activity.
human	ADA	genes/human/ADA/ADA-ai-review.yaml	ADA	P00813	NCBITaxon:9606	Homo sapiens	41	R-HSA-9754964	ADA deamidates RBV	yes	reactome/R-HSA-9754964.md	ADA deamidates RBV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The ribavirin deamidation event is assigned to cytosolic ADA.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	47	R-HSA-1474228	Degradation of the extracellular matrix	yes	reactome/R-HSA-1474228.md	Degradation of the extracellular matrix	Homo sapiens	GO:0022617	extracellular matrix disassembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ADAM10 contributes to ECM remodeling/disassembly (Reactome collagen/ECM degradation), a downstream tissue-level consequence of its sheddase activity.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	48	R-HSA-4224014	E-cadherin degradation by ADAM10, ADAM15	yes	reactome/R-HSA-4224014.md	E-cadherin degradation by ADAM10, ADAM15	Homo sapiens	GO:0004222	metalloendopeptidase activity	TAS	enables	MF	false		ACCEPT	ADAM10 is a zinc-dependent metalloendopeptidase (EC 3.4.24.81) that hydrolyzes peptide bonds in substrate ectodomains via its HEXGHXXGXXHD catalytic motif.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	95	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Portions of nascent ADAM10 reside in the ER lumen during folding and maturation, an early secretory-pathway step rather than a site of catalysis.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	96	R-HSA-9010074	ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane	yes	reactome/R-HSA-9010074.md	ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Portions of nascent ADAM10 reside in the ER lumen during folding and maturation, an early secretory-pathway step rather than a site of catalysis.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	97	R-HSA-9010113	ADAM10:Zn2+ binds TSPANs	yes	reactome/R-HSA-9010113.md	ADAM10:Zn2+ binds TSPANs	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Portions of nascent ADAM10 reside in the ER lumen during folding and maturation, an early secretory-pathway step rather than a site of catalysis.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	99	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ADAM10 is annotated to neutrophil specific granule membranes (Reactome neutrophil degranulation), a leukocyte-specific compartment peripheral to its core role.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	100	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ADAM10 is annotated to neutrophil tertiary granule membranes, reflecting its presence in granulocyte degranulation compartments rather than its core sheddase site.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	110	R-HSA-2220944	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	yes	reactome/R-HSA-2220944.md	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	111	R-HSA-2220976	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	yes	reactome/R-HSA-2220976.md	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	112	R-HSA-2666278	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	yes	reactome/R-HSA-2666278.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	113	R-HSA-2730752	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	yes	reactome/R-HSA-2730752.md	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	114	R-HSA-4224014	E-cadherin degradation by ADAM10, ADAM15	yes	reactome/R-HSA-4224014.md	E-cadherin degradation by ADAM10, ADAM15	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	115	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	116	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	117	R-HSA-9010034	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	yes	reactome/R-HSA-9010034.md	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	118	R-HSA-9010074	ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane	yes	reactome/R-HSA-9010074.md	ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAM10	genes/human/ADAM10/ADAM10-ai-review.yaml	ADAM10	O14672	NCBITaxon:9606	Homo sapiens	119	R-HSA-9013284	NOTCH3-ligand complex is cleaved to produce NEXT3	yes	reactome/R-HSA-9013284.md	NOTCH3-ligand complex is cleaved to produce NEXT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ADAM10 is a single-pass type I membrane protein localized at the plasma membrane, the principal site where it cleaves substrate ectodomains in cis and in trans.
human	ADAMTSL1	genes/human/ADAMTSL1/ADAMTSL1-ai-review.yaml	ADAMTSL1	Q8N6G6	NCBITaxon:9606	Homo sapiens	2	R-HSA-5173005	B3GALTL transfers glucose to O-fucosyl-proteins	yes	reactome/R-HSA-5173005.md	B3GALTL transfers glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True but non-core. ADAMTSL1's thrombospondin repeats really are glucosylated by B3GLCT in the ER lumen, so the protein occupies that compartment during biosynthesis; it acts in the extracellular matrix.
human	ADAMTSL1	genes/human/ADAMTSL1/ADAMTSL1-ai-review.yaml	ADAMTSL1	Q8N6G6	NCBITaxon:9606	Homo sapiens	3	R-HSA-5173192	POFUT2 transfers fucose to TSR domain-containing proteins	yes	reactome/R-HSA-5173192.md	POFUT2 transfers fucose to TSR domain-containing proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Same statement as the B3GLCT row, from the upstream reaction of the same pathway. POFUT2 acts on ADAMTSL1's thrombospondin repeats in the ER lumen; kept as a transit location rather than a functional one.
human	ADAMTSL1	genes/human/ADAMTSL1/ADAMTSL1-ai-review.yaml	ADAMTSL1	Q8N6G6	NCBITaxon:9606	Homo sapiens	4	R-HSA-6785565	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	yes	reactome/R-HSA-6785565.md	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The weakest of the three identical rows: it derives from a Reactome FailedReaction modelling the Peters-plus disease state, in which the B3GALTL G393E variant does not glucosylate its substrates. The location it asserts is still correct, but it carries no information the two working reactions do not already supply.
human	ADAMTSL4	genes/human/ADAMTSL4/ADAMTSL4-ai-review.yaml	ADAMTSL4	Q6UY14	NCBITaxon:9606	Homo sapiens	11	R-HSA-5173005	B3GALTL transfers glucose to O-fucosyl-proteins	yes	reactome/R-HSA-5173005.md	B3GALTL transfers glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	This annotation indicates ADAMTSL4 transits through the ER lumen, based on Reactome pathway data for B3GALTL-mediated glucose transfer to O-fucosylated proteins. ADAMTSL4's thrombospondin type-1 repeats undergo O-fucosylation in the ER.
human	ADAMTSL4	genes/human/ADAMTSL4/ADAMTSL4-ai-review.yaml	ADAMTSL4	Q6UY14	NCBITaxon:9606	Homo sapiens	12	R-HSA-5173192	POFUT2 transfers fucose to TSR domain-containing proteins	yes	reactome/R-HSA-5173192.md	POFUT2 transfers fucose to TSR domain-containing proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	This annotation derives from Reactome pathway data for POFUT2-mediated fucose transfer to TSR domain-containing proteins, which occurs in the ER lumen.
human	ADAMTSL4	genes/human/ADAMTSL4/ADAMTSL4-ai-review.yaml	ADAMTSL4	Q6UY14	NCBITaxon:9606	Homo sapiens	13	R-HSA-6785565	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	yes	reactome/R-HSA-6785565.md	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	This annotation relates to the pathway for defective B3GALTL, which fails to transfer glucose to O-fucosylated proteins. ADAMTSL4 is a substrate for this glycosylation pathway.
human	ADIPOQ	genes/human/ADIPOQ/ADIPOQ-ai-review.yaml	ADIPOQ	Q15848	NCBITaxon:9606	Homo sapiens	106	R-HSA-1183058	Expression of Adiponectin	yes	reactome/R-HSA-1183058.md	Expression of Adiponectin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Adiponectin is a secreted plasma protein; the extracellular region is its core location.
human	ADIPOQ	genes/human/ADIPOQ/ADIPOQ-ai-review.yaml	ADIPOQ	Q15848	NCBITaxon:9606	Homo sapiens	107	R-HSA-8848663	ADIPOQ trimer binds ADIPOR dimers	yes	reactome/R-HSA-8848663.md	ADIPOQ trimer binds ADIPOR dimers	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Adiponectin is a secreted plasma protein; the extracellular region is its core location.
human	ADM2	genes/human/ADM2/ADM2-ai-review.yaml	ADM2	Q7Z4H4	NCBITaxon:9606	Homo sapiens	16	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation placing ADM2 in the extracellular region as part of the Gs-activating GPCR signaling complex. Consistent with its role as a secreted hormone ligand.
human	ADM2	genes/human/ADM2/ADM2-ai-review.yaml	ADM2	Q7Z4H4	NCBITaxon:9606	Homo sapiens	17	R-HSA-420214	The adrenomedullin receptor can bind adrenomedullin and intermedin	yes	reactome/R-HSA-420214.md	The adrenomedullin receptor can bind adrenomedullin and intermedin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation specifically documenting that intermedin (ADM2) binds to the adrenomedullin receptor in the extracellular region.
human	ADM2	genes/human/ADM2/ADM2-ai-review.yaml	ADM2	Q7Z4H4	NCBITaxon:9606	Homo sapiens	18	R-HSA-744886	The Ligand:GPCR:Gs complex dissociates	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ligand:GPCR:Gs complex dissociation, placing ADM2 in the extracellular region. Redundant with other extracellular region annotations.
human	ADM2	genes/human/ADM2/ADM2-ai-review.yaml	ADM2	Q7Z4H4	NCBITaxon:9606	Homo sapiens	19	R-HSA-744887	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for liganded Gs-activating GPCRs binding inactive heterotrimeric Gs. Places ADM2 as extracellular ligand.
human	ADNP	genes/human/ADNP/ADNP-ai-review.yaml	ADNP	Q9H2P0	NCBITaxon:9606	Homo sapiens	44	R-HSA-9940477	Formation of ChAHP complex	yes	reactome/R-HSA-9940477.md	Formation of ChAHP complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The nucleoplasmic ChAHP assembly supports this localization.
human	ADO	genes/human/ADO/ADO-ai-review.yaml	ADO	Q96SZ5	NCBITaxon:9606	Homo sapiens	19	R-HSA-6814153	ADO oxidises 2AET to HTAU	yes	reactome/R-HSA-6814153.md	ADO oxidises 2AET to HTAU	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization of ADO for the cysteamine-to-hypotaurine reaction. This is the authoritative core location of ADO.
human	ADPRS	genes/human/ADPRS/ADPRS-ai-review.yaml	ADPRS	Q9NX46	NCBITaxon:9606	Homo sapiens	2	R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	yes	reactome/R-HSA-110373.md	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Homo sapiens	GO:0006287	base-excision repair, gap-filling	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	A mitochondrial-matrix reaction inheriting a nucleoplasmic gap-filling term by pathway containment. ARH3 neither excises a base nor fills a gap.
human	ADPRS	genes/human/ADPRS/ADPRS-ai-review.yaml	ADPRS	Q9NX46	NCBITaxon:9606	Homo sapiens	30	R-HSA-8952903	ADPRHL2 hydrolyses poly(ADP-ribose)	yes	reactome/R-HSA-8952903.md	ADPRHL2 hydrolyses poly(ADP-ribose)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places its ADPRHL2 PAR-hydrolysis reaction in the mitochondrial matrix, matching the experimental rows.
human	ADPRS	genes/human/ADPRS/ADPRS-ai-review.yaml	ADPRS	Q9NX46	NCBITaxon:9606	Homo sapiens	46	R-HSA-8952903	ADPRHL2 hydrolyses poly(ADP-ribose)	yes	reactome/R-HSA-8952903.md	ADPRHL2 hydrolyses poly(ADP-ribose)	Homo sapiens	GO:0004649	poly(ADP-ribose) glycohydrolase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'ADPRHL2 hydrolyses poly(ADP-ribose)' - a faithful, single-gene statement.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	70	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	71	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	72	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	73	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	74	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	75	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	76	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Clathrin-coated endocytic vesicle membrane is a supported receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	86	R-HSA-5696968	USP20, USP33 deubiquitinate ADRB2	yes	reactome/R-HSA-5696968.md	USP20, USP33 deubiquitinate ADRB2	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endosome membrane is a supported post-endocytic receptor trafficking location.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	87	R-HSA-8851797	ADRB2 in ADRB2:GRK complex is phosphorylated	yes	reactome/R-HSA-8851797.md	ADRB2 in ADRB2:GRK complex is phosphorylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	88	R-HSA-8852167	ADRB2:Catecholamine binds ARRB1, ARRB2	yes	reactome/R-HSA-8852167.md	ADRB2:Catecholamine binds ARRB1, ARRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	89	R-HSA-8866269	ARRB bind GPCRs	yes	reactome/R-HSA-8866269.md	ARRB bind GPCRs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	90	R-HSA-8866283	ARBB recruits GPCRs into clathrin-coated pits	yes	reactome/R-HSA-8866283.md	ARBB recruits GPCRs into clathrin-coated pits	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	91	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	92	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	93	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	94	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	95	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	96	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	97	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	98	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	99	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	100	R-HSA-8982641	ADRB2:GRK complex dissociates to Phosphorylated ADRB2	yes	reactome/R-HSA-8982641.md	ADRB2:GRK complex dissociates to Phosphorylated ADRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	106	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	107	R-HSA-744886	The Ligand:GPCR:Gs complex dissociates	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	108	R-HSA-744887	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	109	R-HSA-8982645	GRKs bind ADRB2:Catecholamine	yes	reactome/R-HSA-8982645.md	GRKs bind ADRB2:Catecholamine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	110	R-HSA-9609310	β-blockers bind ADRB1,2,3	yes	reactome/R-HSA-9609310.md	β-blockers bind ADRB1,2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	111	R-HSA-9611751	β1,2-agonists bind ADRB1,2	yes	reactome/R-HSA-9611751.md	β1,2-agonists bind ADRB1,2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRB2	genes/human/ADRB2/ADRB2-ai-review.yaml	ADRB2	P07550	NCBITaxon:9606	Homo sapiens	112	R-HSA-9611851	ADRB2 bind ADR,NAd	yes	reactome/R-HSA-9611851.md	ADRB2 bind ADR,NAd	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane is the primary active location for ADRB2 catecholamine receptor signaling.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	38	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	39	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	40	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	41	R-HSA-5635854	GLI2,3 are degraded by the proteasome	yes	reactome/R-HSA-5635854.md	GLI2,3 are degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	42	R-HSA-68825	Ubiquitinated geminin is degraded by the proteasome	yes	reactome/R-HSA-68825.md	Ubiquitinated geminin is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	43	R-HSA-69600	Proteolytic degradation of ubiquitinated-Cdc25A	yes	reactome/R-HSA-69600.md	Proteolytic degradation of ubiquitinated-Cdc25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	44	R-HSA-8939801	26S proteasome degrades PolyUb-RUNX2	yes	reactome/R-HSA-8939801.md	26S proteasome degrades PolyUb-RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	45	R-HSA-8952408	Polyubiquitinated RUNX3 is degraded by the proteasome	yes	reactome/R-HSA-8952408.md	Polyubiquitinated RUNX3 is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	46	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	47	R-NUL-9604648	Proteasome degrades ubiquitinated mouse NICD4	yes	reactome/R-NUL-9604648.md	Proteasome degrades ubiquitinated mouse NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ADRM1-containing proteasomes are reported in the nucleus/nucleoplasm as part of the 26S proteasome distribution.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	48	R-HSA-1168640	Ubiquitinated IkB is degraded	yes	reactome/R-HSA-1168640.md	Ubiquitinated IkB is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	49	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	50	R-HSA-1236970	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	yes	reactome/R-HSA-1236970.md	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	51	R-HSA-1504193	Ubiquitinated DVL is degraded by the proteasome	yes	reactome/R-HSA-1504193.md	Ubiquitinated DVL is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	52	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	53	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	54	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	55	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	56	R-HSA-180573	Degradation of ubiquitinated CD4	yes	reactome/R-HSA-180573.md	Degradation of ubiquitinated CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	57	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	58	R-HSA-209061	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	yes	reactome/R-HSA-209061.md	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	59	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	60	R-HSA-264458	Proteasome mediated degradation of COP1	yes	reactome/R-HSA-264458.md	Proteasome mediated degradation of COP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	61	R-HSA-353125	26S proteosome degrades ODC holoenzyme complex	yes	reactome/R-HSA-353125.md	26S proteosome degrades ODC holoenzyme complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	62	R-HSA-3640874	Ub-RibC-AXIN is degraded by the proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	63	R-HSA-450466	AUF1:mRNA complex is degraded	yes	reactome/R-HSA-450466.md	AUF1:mRNA complex is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	64	R-HSA-4608855	PRICKLE1 is degraded by the proteasome	yes	reactome/R-HSA-4608855.md	PRICKLE1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	65	R-HSA-4641256	Ubiquitinated AXIN is degraded by the proteasome	yes	reactome/R-HSA-4641256.md	Ubiquitinated AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	66	R-HSA-4641260	Ubiquitinated DVL1 is degraded by the proteasome	yes	reactome/R-HSA-4641260.md	Ubiquitinated DVL1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	67	R-HSA-5362448	Hh C-terminal fragments are degraded by the proteasome	yes	reactome/R-HSA-5362448.md	Hh C-terminal fragments are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	68	R-HSA-5387392	processing defective Hh variants are degraded by the proteasome	yes	reactome/R-HSA-5387392.md	processing defective Hh variants are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	69	R-HSA-5607724	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	yes	reactome/R-HSA-5607724.md	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	70	R-HSA-5607731	26S proteasome processes p-7S-p100:RELB to form p52:RELB	yes	reactome/R-HSA-5607731.md	26S proteasome processes p-7S-p100:RELB to form p52:RELB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	71	R-HSA-5610754	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	yes	reactome/R-HSA-5610754.md	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	72	R-HSA-5610758	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	yes	reactome/R-HSA-5610758.md	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	73	R-HSA-5610760	GLI1 is degraded by the proteasome after ubiquitination by ITCH	yes	reactome/R-HSA-5610760.md	GLI1 is degraded by the proteasome after ubiquitination by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	74	R-HSA-5635868	ub-GLI is degraded by the proteasome	yes	reactome/R-HSA-5635868.md	ub-GLI is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	75	R-HSA-5658430	NF1 is degraded by the proteasome	yes	reactome/R-HSA-5658430.md	NF1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	76	R-HSA-5665854	ADRM1:26S proteaseome binds UCHL5	yes	reactome/R-HSA-5665854.md	ADRM1:26S proteaseome binds UCHL5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	77	R-HSA-5665871	ADRM1 binds 26S proteasome	yes	reactome/R-HSA-5665871.md	ADRM1 binds 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	78	R-HSA-5668481	Protesomal degradation of K48polyUb-TRAF3	yes	reactome/R-HSA-5668481.md	Protesomal degradation of K48polyUb-TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	79	R-HSA-5668520	26Sproteasome degrades K48polyUb-NIK	yes	reactome/R-HSA-5668520.md	26Sproteasome degrades K48polyUb-NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	80	R-HSA-5687112	MAPK6 is degraded by the 26S proteasome	yes	reactome/R-HSA-5687112.md	MAPK6 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	81	R-HSA-5689539	ADRM1:26S proteaseome binds USP14	yes	reactome/R-HSA-5689539.md	ADRM1:26S proteaseome binds USP14	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	82	R-HSA-68948	Ubiquitinated Orc1 is degraded by the proteasome	yes	reactome/R-HSA-68948.md	Ubiquitinated Orc1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	83	R-HSA-69016	Ubiquitinated Cdc6 is degraded by the proteasome	yes	reactome/R-HSA-69016.md	Ubiquitinated Cdc6 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	84	R-HSA-75825	Proteasome mediated degradation of Cyclin D1	yes	reactome/R-HSA-75825.md	Proteasome mediated degradation of Cyclin D1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	85	R-HSA-8850992	Proteasome degrades polyubiquitinated PTEN	yes	reactome/R-HSA-8850992.md	Proteasome degrades polyubiquitinated PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	86	R-HSA-8852354	GTSE1 facilitates proteasome-mediated degradation of TP53	yes	reactome/R-HSA-8852354.md	GTSE1 facilitates proteasome-mediated degradation of TP53	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	87	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	88	R-HSA-8854071	Proteasome-mediated degradation of PolyUb-FBXL7	yes	reactome/R-HSA-8854071.md	Proteasome-mediated degradation of PolyUb-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	89	R-HSA-8866553	misfolded CFTR is degraded by the 26S proteasome	yes	reactome/R-HSA-8866553.md	misfolded CFTR is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	90	R-HSA-8866858	CFTR F508del is degraded by the 26S proteasome	yes	reactome/R-HSA-8866858.md	CFTR F508del is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	91	R-HSA-8932355	26S proteasome degrades Ub-NFE2L2	yes	reactome/R-HSA-8932355.md	26S proteasome degrades Ub-NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	92	R-HSA-8956140	NEDD8 and UBD bind NUB1 and the 26S proteasome	yes	reactome/R-HSA-8956140.md	NEDD8 and UBD bind NUB1 and the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	93	R-HSA-8956184	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	yes	reactome/R-HSA-8956184.md	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	94	R-HSA-8957265	26S proteasome degrades TP73 polyubiquitinated by ITCH	yes	reactome/R-HSA-8957265.md	26S proteasome degrades TP73 polyubiquitinated by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	95	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	96	R-HSA-9755306	ub UBXN7 is degraded by the 26S proteasome	yes	reactome/R-HSA-9755306.md	ub UBXN7 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	97	R-HSA-9766223	Proteasome-dependent degradation of ubiquitinated CDH1	yes	reactome/R-HSA-9766223.md	Proteasome-dependent degradation of ubiquitinated CDH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	98	R-HSA-983150	Proteasomal cleavage of substrate	yes	reactome/R-HSA-983150.md	Proteasomal cleavage of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	99	R-HSA-9907980	Formation of the 19S regulatory particle base precursor	yes	reactome/R-HSA-9907980.md	Formation of the 19S regulatory particle base precursor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	100	R-HSA-9908026	Formation of the 19S regulatory particle precursor	yes	reactome/R-HSA-9908026.md	Formation of the 19S regulatory particle precursor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	101	R-HSA-9908178	Formation of the 26S proteasome	yes	reactome/R-HSA-9908178.md	Formation of the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	102	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	103	R-HSA-9929486	SPOP-mediated degradation of CD274 by 26S Proteosome	yes	reactome/R-HSA-9929486.md	SPOP-mediated degradation of CD274 by 26S Proteosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	104	R-HSA-9931314	Proteasomal degradation of polyUb-p-S195-CD274	yes	reactome/R-HSA-9931314.md	Proteasomal degradation of polyUb-p-S195-CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	105	R-HSA-9934893	Proteolysis of K48polyUb-K,p-S-PER1,2,3	yes	reactome/R-HSA-9934893.md	Proteolysis of K48polyUb-K,p-S-PER1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	106	R-HSA-9954728	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	yes	reactome/R-HSA-9954728.md	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	107	R-NUL-212917	Proteasome mediated degradation of PAK-2p34	yes	reactome/R-NUL-212917.md	Proteasome mediated degradation of PAK-2p34	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	108	R-NUL-5610751	Gli2is degraded by the proteasome	yes	reactome/R-NUL-5610751.md	Gli2is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADRM1	genes/human/ADRM1/ADRM1-ai-review.yaml	ADRM1	Q16186	NCBITaxon:9606	Homo sapiens	109	R-NUL-9011324	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	yes	reactome/R-NUL-9011324.md	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	Caenorhabditis elegans	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ADRM1-containing 26S proteasomes act in cytosolic protein degradation, and independent localization annotations also support cytosol/cytoplasm.
human	ADSL	genes/human/ADSL/ADSL-ai-review.yaml	ADSL	P30566	NCBITaxon:9606	Homo sapiens	26	R-HSA-73800	SAICAR => AICAR + Fumarate	yes	reactome/R-HSA-73800.md	SAICAR => AICAR + Fumarate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The SAICAR-cleaving ADSL tetramer acts in the cytosol.
human	ADSL	genes/human/ADSL/ADSL-ai-review.yaml	ADSL	P30566	NCBITaxon:9606	Homo sapiens	27	R-HSA-73828	adenylosuccinate => adenosine 5'-monophosphate + fumarate	yes	reactome/R-HSA-73828.md	adenylosuccinate => adenosine 5'-monophosphate + fumarate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The adenylosuccinate-cleaving ADSL tetramer acts in the cytosol.
human	ADSS1	genes/human/ADSS1/ADSS1-ai-review.yaml	ADSS1	Q8N142	NCBITaxon:9606	Homo sapiens	18	R-HSA-111524	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]	yes	reactome/R-HSA-111524.md	IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome for the adenylosuccinate synthase reaction, consistent with the soluble cytosolic nature of the enzyme.
human	AEBP2	genes/human/AEBP2/AEBP2-ai-review.yaml	AEBP2	Q6ZN18	NCBITaxon:9606	Homo sapiens	17	R-HSA-212252	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin	yes	reactome/R-HSA-212252.md	Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	A Reactome pathway-level location assignment for the reaction in which PRC2 is recruited to chromatin. Correct but redundant with the HPA IDA row.
human	AEBP2	genes/human/AEBP2/AEBP2-ai-review.yaml	AEBP2	Q6ZN18	NCBITaxon:9606	Homo sapiens	18	R-HSA-212263	PRC2 trimethylates histone H3 at lysine-27	yes	reactome/R-HSA-212263.md	PRC2 trimethylates histone H3 at lysine-27	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The same Reactome compartment assignment for the H3K27 trimethylation reaction. Correct and redundant.
human	AEBP2	genes/human/AEBP2/AEBP2-ai-review.yaml	AEBP2	Q6ZN18	NCBITaxon:9606	Homo sapiens	19	R-HSA-5638332	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)	yes	reactome/R-HSA-5638332.md	PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The third Reactome compartment row, from a reaction whose name identifies AEBP2 as part of the acting complex. Correct and redundant.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	31	R-HSA-112379	Recruitment of elongation factors to form elongation complex	yes	reactome/R-HSA-112379.md	Recruitment of elongation factors to form elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. One of eleven Reactome rows carrying the same true term from separate reactions of the polymerase II elongation complex.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	32	R-HSA-112381	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex	yes	reactome/R-HSA-112381.md	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome reaction in which P-TEFb hyperphosphorylates the polymerase II CTD.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	33	R-HSA-112385	Addition of nucleotides leads to transcript elongation	yes	reactome/R-HSA-112385.md	Addition of nucleotides leads to transcript elongation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the nucleotide-addition reaction of the Reactome elongation complex.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	34	R-HSA-112392	Resumption of elongation after recovery from pausing	yes	reactome/R-HSA-112392.md	Resumption of elongation after recovery from pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome reaction for resumption of elongation after pausing.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	35	R-HSA-112395	Abortive termination of elongation after arrest	yes	reactome/R-HSA-112395.md	Abortive termination of elongation after arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome abortive-termination reaction.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	36	R-HSA-112396	Separation of elongating transcript from template	yes	reactome/R-HSA-112396.md	Separation of elongating transcript from template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome transcript-separation reaction.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	37	R-HSA-113411	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	yes	reactome/R-HSA-113411.md	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome short-backtracking reaction.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	38	R-HSA-113412	Pol II elongation complex moves on the template as transcript elongates	yes	reactome/R-HSA-113412.md	Pol II elongation complex moves on the template as transcript elongates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome reaction for processive movement of the elongation complex.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	39	R-HSA-113413	TFIIS-mediated recovery of elongation from arrest	yes	reactome/R-HSA-113413.md	TFIIS-mediated recovery of elongation from arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome TFIIS-mediated recovery reaction.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	40	R-HSA-113414	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	yes	reactome/R-HSA-113414.md	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome long-backtracking reaction.
human	AFF4	genes/human/AFF4/AFF4-ai-review.yaml	AFF4	Q9UHB7	NCBITaxon:9606	Homo sapiens	41	R-HSA-113429	Elongating transcript encounters a lesion in the template	yes	reactome/R-HSA-113429.md	Elongating transcript encounters a lesion in the template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accepted. The same compartment statement, from the Reactome reaction in which the elongating transcript meets a template lesion.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	60	R-HSA-8949649	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	yes	reactome/R-HSA-8949649.md	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	61	R-HSA-8949659	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU	yes	reactome/R-HSA-8949659.md	AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	62	R-HSA-8949661	C2orf47:AFG3L2 binds the transit peptide of SMDT1	yes	reactome/R-HSA-8949661.md	C2orf47:AFG3L2 binds the transit peptide of SMDT1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	63	R-HSA-9838627	AFG3L2 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838627.md	AFG3L2 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	64	R-HSA-9839053	AFG3L2:SPG7 binds SMDT1 (EMRE)	yes	reactome/R-HSA-9839053.md	AFG3L2:SPG7 binds SMDT1 (EMRE)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	65	R-HSA-9839059	AFG3L2:SPG7 degrades SMDT1 (EMRE)	yes	reactome/R-HSA-9839059.md	AFG3L2:SPG7 degrades SMDT1 (EMRE)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	66	R-HSA-9839105	AFG3L2 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9839105.md	AFG3L2 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	67	R-HSA-9839113	AFG3L2 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9839113.md	AFG3L2 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFG3L2	genes/human/AFG3L2/AFG3L2-ai-review.yaml	AFG3L2	Q9Y4W6	NCBITaxon:9606	Homo sapiens	68	R-HSA-9839149	AFG3L2 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9839149.md	AFG3L2 binds mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places the m-AAA machinery at the mitochondrial inner membrane.
human	AFP	genes/human/AFP/AFP-ai-review.yaml	AFP	P02771	NCBITaxon:9606	Homo sapiens	7	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Correct but incidental. The Reactome reaction behind this row is FAM20C phosphorylates FAM20C substrates, which is annotated to the endoplasmic reticulum lumen compartment, and AFP is on the substrate list with real backing, because UniProt records six FAM20C phosphoserines on AFP at Ser-111, Ser-115, Ser-117, Ser-344, Ser-444 and Ser-445, each carrying ECO:0000269 to PMID:26091039. So the protein demonstrably is in the ER lumen. It is there because every secreted protein passes through it.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	16	R-HSA-8863718	AGFG1 binds VAMP7	yes	reactome/R-HSA-8863718.md	AGFG1 binds VAMP7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. This entry and the fifteen that follow are one claim: sixteen GOA rows that differ only in the Reactome reaction id, all asserting cytosol. They are analysed here as a set and each retains its own entry so the review reconciles one-to-one with the GOA file.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	17	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. One of the fifteen generic clathrin-pathway reactions; see the R-HSA-8863718 entry for the shared analysis.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	18	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. This is the one generic reaction of the fifteen whose description does cover AGFG1's role, since AGFG1 is a CLASP; see the R-HSA-8863718 entry for the shared analysis.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	19	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	20	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	21	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	22	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	23	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	24	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	25	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	26	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	27	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	28	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	29	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	30	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGFG1	genes/human/AGFG1/AGFG1-ai-review.yaml	AGFG1	P52594	NCBITaxon:9606	Homo sapiens	31	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Generic clathrin-pathway reaction; see the R-HSA-8863718 entry.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	25	R-HSA-5696074	AGK:Mg2+ phosphorylates MAG, DAG	yes	reactome/R-HSA-5696074.md	AGK:Mg2+ phosphorylates MAG, DAG	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		UNDECIDED	An IMS-proximity source does not independently establish outer-membrane attachment of AGK.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	28	R-HSA-6802927	BRAF and RAF fusion mutant dimers are phosphorylated	yes	reactome/R-HSA-6802927.md	BRAF and RAF fusion mutant dimers are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The Reactome cytosolic entity in these events is an oncogenic AGK-BRAF fusion.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	29	R-HSA-6802932	Dissociation of BRAF/RAF fusion complex	yes	reactome/R-HSA-6802932.md	Dissociation of BRAF/RAF fusion complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The Reactome cytosolic entity in these events is an oncogenic AGK-BRAF fusion.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	30	R-HSA-6802933	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	yes	reactome/R-HSA-6802933.md	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The Reactome cytosolic entity in these events is an oncogenic AGK-BRAF fusion.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	31	R-HSA-6802934	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802934.md	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The Reactome cytosolic entity in these events is an oncogenic AGK-BRAF fusion.
human	AGK	genes/human/AGK/AGK-ai-review.yaml	AGK	Q53H12	NCBITaxon:9606	Homo sapiens	32	R-HSA-6802935	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	yes	reactome/R-HSA-6802935.md	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The Reactome cytosolic entity in these events is an oncogenic AGK-BRAF fusion.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	20	R-HSA-70221	Glycogen breakdown (glycogenolysis)	yes	reactome/R-HSA-70221.md	Glycogen breakdown (glycogenolysis)	Homo sapiens	GO:0005980	glycogen catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome places AGL in the glycogen-breakdown pathway.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		UNDECIDED	Reactome models extracellular AGL after secretory-granule exocytosis, but direct release evidence remains unresolved.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	28	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		UNDECIDED	Reactome models extracellular AGL after ficolin-rich-granule exocytosis, but direct release evidence remains unresolved.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		UNDECIDED	Reactome assigns AGL to the secretory-granule lumen, while its intragranular topology remains unresolved.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	30	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		UNDECIDED	Reactome assigns AGL to the ficolin-rich-granule lumen, while its intragranular topology remains unresolved.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	31	R-HSA-71552	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin	yes	reactome/R-HSA-71552.md	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The AGL glucan-transfer reaction occurs in the cytosol.
human	AGL	genes/human/AGL/AGL-ai-review.yaml	AGL	P35573	NCBITaxon:9606	Homo sapiens	32	R-HSA-71593	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose	yes	reactome/R-HSA-71593.md	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The AGL branch-hydrolysis reaction occurs in the cytosol.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	64	R-HSA-5578742	AGO1,2:small RNA complexes interact with chromatin	yes	reactome/R-HSA-5578742.md	AGO1,2:small RNA complexes interact with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	AGO1 occurs in nucleoplasmic chromatin-associated RNA complexes.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	68	R-HSA-1606561	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606561.md	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	69	R-HSA-1606682	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606682.md	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	70	R-HSA-1912362	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912362.md	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR150 microRNA binds 3'UTR of NOTCH3 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	71	R-HSA-1912363	MIR200B/C microRNAs bind NOTCH1 mRNA	yes	reactome/R-HSA-1912363.md	MIR200B/C microRNAs bind NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR200B/C microRNAs bind NOTCH1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	72	R-HSA-1912364	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912364.md	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR181C microRNA binds 3'UTR of NOTCH4 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	73	R-HSA-1912366	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912366.md	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR206 microRNA binds 3'UTR of NOTCH3 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	74	R-HSA-1912367	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	yes	reactome/R-HSA-1912367.md	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	75	R-HSA-1912368	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912368.md	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR302A microRNA binds 3'UTR of NOTCH4 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	76	R-HSA-1912406	p53 positively regulates transcription of MIR34 microRNAs	yes	reactome/R-HSA-1912406.md	p53 positively regulates transcription of MIR34 microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated p53 positively regulates transcription of MIR34 microRNAs context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	77	R-HSA-2318752	miR-26A microRNAs bind PTEN mRNA	yes	reactome/R-HSA-2318752.md	miR-26A microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26A microRNAs bind PTEN mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	78	R-HSA-3209151	miR-24 binds p16INK4A and p14ARF mRNAs	yes	reactome/R-HSA-3209151.md	miR-24 binds p16INK4A and p14ARF mRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-24 binds p16INK4A and p14ARF mRNAs context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	79	R-HSA-426489	RISC binds inexactly matching target RNAs	yes	reactome/R-HSA-426489.md	RISC binds inexactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated RISC binds inexactly matching target RNAs context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	80	R-HSA-426522	Nonendonucleolytic RISC binds exactly matching target RNAs	yes	reactome/R-HSA-426522.md	Nonendonucleolytic RISC binds exactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated Nonendonucleolytic RISC binds exactly matching target RNAs context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	81	R-HSA-4518575	miR-92b binds 3'UTR of NLK mRNA	yes	reactome/R-HSA-4518575.md	miR-92b binds 3'UTR of NLK mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-92b binds 3'UTR of NLK mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	82	R-HSA-5687103	FOXO3 regulates MIR34B,C expression	yes	reactome/R-HSA-5687103.md	FOXO3 regulates MIR34B,C expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated FOXO3 regulates MIR34B,C expression context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	83	R-HSA-8935766	miR-378 binds RUNX1 mRNA	yes	reactome/R-HSA-8935766.md	miR-378 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-378 binds RUNX1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	84	R-HSA-8937097	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	yes	reactome/R-HSA-8937097.md	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	85	R-HSA-8937134	miR-27a binds RUNX1 mRNA	yes	reactome/R-HSA-8937134.md	miR-27a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-27a binds RUNX1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	86	R-HSA-8938440	miR-17 binds RUNX1 mRNA	yes	reactome/R-HSA-8938440.md	miR-17 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-17 binds RUNX1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	87	R-HSA-8938487	miR-20a binds RUNX1 mRNA	yes	reactome/R-HSA-8938487.md	miR-20a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-20a binds RUNX1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	88	R-HSA-8938507	miR-106a binds RUNX1 mRNA	yes	reactome/R-HSA-8938507.md	miR-106a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-106a binds RUNX1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	89	R-HSA-8944650	miR-214 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944650.md	miR-214 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-214 microRNA binds PTEN mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	90	R-HSA-8944684	miR-205 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944684.md	miR-205 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-205 microRNA binds PTEN mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	91	R-HSA-8944706	miR-21 nonendonucleolytic RISC binds PTEN mRNA	yes	reactome/R-HSA-8944706.md	miR-21 nonendonucleolytic RISC binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-21 nonendonucleolytic RISC binds PTEN mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	92	R-HSA-9011958	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	yes	reactome/R-HSA-9011958.md	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26A and B bind to the 3'UTR of the GREB1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	93	R-HSA-9012203	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	yes	reactome/R-HSA-9012203.md	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26A and B bind to the 3'UTR of the CHD11 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	94	R-HSA-9012208	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	yes	reactome/R-HSA-9012208.md	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26A and B bind to the 3'UTR of the KPNA2 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	95	R-HSA-9038545	miR-613 binds to the 3'UTR of the NR1H3 mRNA	yes	reactome/R-HSA-9038545.md	miR-613 binds to the 3'UTR of the NR1H3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-613 binds to the 3'UTR of the NR1H3 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	96	R-HSA-9618392	miR-26 binds to the 3'UTR of the ARL4C mRNA	yes	reactome/R-HSA-9618392.md	miR-26 binds to the 3'UTR of the ARL4C mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26 binds to the 3'UTR of the ARL4C mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	97	R-HSA-9618486	miR-26 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9618486.md	miR-26 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-26 binds to the 3'UTR of the ABCA1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	98	R-HSA-9624925	miR-33 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9624925.md	miR-33 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-33 binds to the 3'UTR of the ABCA1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	99	R-HSA-9657791	miR-144 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9657791.md	miR-144 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-144 binds to the 3'UTR of the ABCA1 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	100	R-HSA-9858289	MITF-M-dependent miR-211 expression	yes	reactome/R-HSA-9858289.md	MITF-M-dependent miR-211 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated MITF-M-dependent miR-211 expression context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	101	R-HSA-9858309	miR-211 RISC binds POU3F2 mRNA	yes	reactome/R-HSA-9858309.md	miR-211 RISC binds POU3F2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated miR-211 RISC binds POU3F2 mRNA context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	102	R-HSA-9924921	CD274 mRNA binds miR-34 RISC	yes	reactome/R-HSA-9924921.md	CD274 mRNA binds miR-34 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated CD274 mRNA binds miR-34 RISC context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	103	R-HSA-9925095	CD274 mRNA binds miR-340 RISC	yes	reactome/R-HSA-9925095.md	CD274 mRNA binds miR-340 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated CD274 mRNA binds miR-340 RISC context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	104	R-HSA-9925158	CD274 mRNA binds miR-152 RISC	yes	reactome/R-HSA-9925158.md	CD274 mRNA binds miR-152 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated CD274 mRNA binds miR-152 RISC context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	105	R-HSA-9925159	CD274 mRNA binds miR-140 RISC	yes	reactome/R-HSA-9925159.md	CD274 mRNA binds miR-140 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated CD274 mRNA binds miR-140 RISC context.
human	AGO1	genes/human/AGO1/AGO1-ai-review.yaml	AGO1	Q9UL18	NCBITaxon:9606	Homo sapiens	106	R-HSA-9925324	CD274 mRNA binds miR-200B/C RISC	yes	reactome/R-HSA-9925324.md	CD274 mRNA binds miR-200B/C RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AGO1 is compatible with the curated CD274 mRNA binds miR-200B/C RISC context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	80	R-HSA-426496	Post-transcriptional silencing by small RNAs	yes	reactome/R-HSA-426496.md	Post-transcriptional silencing by small RNAs	Homo sapiens	GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing	TAS	involved_in	BP	false		ACCEPT	AGO2 supports regulatory ncRNA-mediated post-transcriptional gene silencing in the specified molecular or cellular context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	82	R-HSA-426520	Endonucleolytic RISC hydrolyzes target RNAs	yes	reactome/R-HSA-426520.md	Endonucleolytic RISC hydrolyzes target RNAs	Homo sapiens	GO:0004521	RNA endonuclease activity	TAS	enables	MF	false		ACCEPT	AGO2 supports RNA endonuclease activity in the specified molecular or cellular context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	94	R-HSA-5578742	AGO1,2:small RNA complexes interact with chromatin	yes	reactome/R-HSA-5578742.md	AGO1,2:small RNA complexes interact with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	AGO2 supports nucleoplasm in the specified molecular or cellular context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	95	R-HSA-5578744	Importin-8 imports AGO2:miRNA into the nucleus	yes	reactome/R-HSA-5578744.md	Importin-8 imports AGO2:miRNA into the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	AGO2 supports nucleoplasm in the specified molecular or cellular context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	96	R-HSA-5578966	TNRC6A:AGO2:miRNA is transported into the nucleus	yes	reactome/R-HSA-5578966.md	TNRC6A:AGO2:miRNA is transported into the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	AGO2 supports nucleoplasm in the specified molecular or cellular context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	110	R-HSA-1606561	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606561.md	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	111	R-HSA-1606682	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606682.md	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	112	R-HSA-1912362	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912362.md	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	113	R-HSA-1912363	MIR200B/C microRNAs bind NOTCH1 mRNA	yes	reactome/R-HSA-1912363.md	MIR200B/C microRNAs bind NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	114	R-HSA-1912364	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912364.md	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	115	R-HSA-1912366	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912366.md	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	116	R-HSA-1912367	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	yes	reactome/R-HSA-1912367.md	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	117	R-HSA-1912368	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912368.md	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	118	R-HSA-1912406	p53 positively regulates transcription of MIR34 microRNAs	yes	reactome/R-HSA-1912406.md	p53 positively regulates transcription of MIR34 microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	119	R-HSA-203862	Dicer cleaves pre-miRNA to yield duplex miRNA	yes	reactome/R-HSA-203862.md	Dicer cleaves pre-miRNA to yield duplex miRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	120	R-HSA-2106614	Duplex miRNA is loaded into Argonaute	yes	reactome/R-HSA-2106614.md	Duplex miRNA is loaded into Argonaute	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	121	R-HSA-2106615	Removal of siRNA passenger strand	yes	reactome/R-HSA-2106615.md	Removal of siRNA passenger strand	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	122	R-HSA-2106625	Duplex siRNA is loaded into Argonaute	yes	reactome/R-HSA-2106625.md	Duplex siRNA is loaded into Argonaute	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	123	R-HSA-210805	Removal of miRNA passenger strand	yes	reactome/R-HSA-210805.md	Removal of miRNA passenger strand	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	124	R-HSA-2318752	miR-26A microRNAs bind PTEN mRNA	yes	reactome/R-HSA-2318752.md	miR-26A microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	125	R-HSA-426464	Dicer cleaves double-stranded RNA to yield double-stranded siRNA	yes	reactome/R-HSA-426464.md	Dicer cleaves double-stranded RNA to yield double-stranded siRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	126	R-HSA-426489	RISC binds inexactly matching target RNAs	yes	reactome/R-HSA-426489.md	RISC binds inexactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	127	R-HSA-426520	Endonucleolytic RISC hydrolyzes target RNAs	yes	reactome/R-HSA-426520.md	Endonucleolytic RISC hydrolyzes target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	128	R-HSA-4518575	miR-92b binds 3'UTR of NLK mRNA	yes	reactome/R-HSA-4518575.md	miR-92b binds 3'UTR of NLK mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	129	R-HSA-5578712	Importin-8 binds AGO2:miRNA	yes	reactome/R-HSA-5578712.md	Importin-8 binds AGO2:miRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	130	R-HSA-5578744	Importin-8 imports AGO2:miRNA into the nucleus	yes	reactome/R-HSA-5578744.md	Importin-8 imports AGO2:miRNA into the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	131	R-HSA-5578965	TNRC6A binds AGO2:miRNA	yes	reactome/R-HSA-5578965.md	TNRC6A binds AGO2:miRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	132	R-HSA-5578966	TNRC6A:AGO2:miRNA is transported into the nucleus	yes	reactome/R-HSA-5578966.md	TNRC6A:AGO2:miRNA is transported into the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	133	R-HSA-5687103	FOXO3 regulates MIR34B,C expression	yes	reactome/R-HSA-5687103.md	FOXO3 regulates MIR34B,C expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	134	R-HSA-8935864	miR-302b binds RUNX1 mRNA	yes	reactome/R-HSA-8935864.md	miR-302b binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	135	R-HSA-8935930	miR-18a binds RUNX1 mRNA	yes	reactome/R-HSA-8935930.md	miR-18a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	136	R-HSA-8936058	miR-675 binds RUNX1 mRNA	yes	reactome/R-HSA-8936058.md	miR-675 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	137	R-HSA-8936068	H19 is cleaved to produce miR-675	yes	reactome/R-HSA-8936068.md	H19 is cleaved to produce miR-675	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	138	R-HSA-8939129	miR-215 binds RUNX1 mRNA	yes	reactome/R-HSA-8939129.md	miR-215 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	139	R-HSA-8944483	miR-17 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944483.md	miR-17 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	140	R-HSA-8944522	miR-19a microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944522.md	miR-19a microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	141	R-HSA-8944538	miR-22 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944538.md	miR-22 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	142	R-HSA-8944569	miR-25 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944569.md	miR-25 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	143	R-HSA-8944599	miR-93 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944599.md	miR-93 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	144	R-HSA-8944632	miR-106 microRNAs bind PTEN mRNA	yes	reactome/R-HSA-8944632.md	miR-106 microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	145	R-HSA-8944684	miR-205 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944684.md	miR-205 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	146	R-HSA-8945709	miR-20 microRNAs bind PTEN mRNA	yes	reactome/R-HSA-8945709.md	miR-20 microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	147	R-HSA-8948524	PTENP1 mRNA binds miR-19b RISC	yes	reactome/R-HSA-8948524.md	PTENP1 mRNA binds miR-19b RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	148	R-HSA-8948536	PTENP1 mRNA binds miR-20 RISC	yes	reactome/R-HSA-8948536.md	PTENP1 mRNA binds miR-20 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	149	R-HSA-8948569	miR-19b microRNA binds PTEN mRNA	yes	reactome/R-HSA-8948569.md	miR-19b microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	150	R-HSA-8948582	miR-17 microRNA binds VAPA mRNA	yes	reactome/R-HSA-8948582.md	miR-17 microRNA binds VAPA mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	151	R-HSA-8948583	miR-17 microRNA binds CNOT6L mRNA	yes	reactome/R-HSA-8948583.md	miR-17 microRNA binds CNOT6L mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	152	R-HSA-8948594	miR-19a microRNA binds VAPA mRNA	yes	reactome/R-HSA-8948594.md	miR-19a microRNA binds VAPA mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	153	R-HSA-8948602	miR-19a microRNA binds CNOT6L mRNA	yes	reactome/R-HSA-8948602.md	miR-19a microRNA binds CNOT6L mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	154	R-HSA-8948612	miR-19b microRNA binds CNOT6L mRNA	yes	reactome/R-HSA-8948612.md	miR-19b microRNA binds CNOT6L mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	155	R-HSA-8948621	miR-20 microRNAs bind VAPA mRNA	yes	reactome/R-HSA-8948621.md	miR-20 microRNAs bind VAPA mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	156	R-HSA-8948623	miR-20 microRNAs bind CNOT6L mRNA	yes	reactome/R-HSA-8948623.md	miR-20 microRNAs bind CNOT6L mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	157	R-HSA-8948641	miR-106 microRNAs bind VAPA mRNA	yes	reactome/R-HSA-8948641.md	miR-106 microRNAs bind VAPA mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	158	R-HSA-8948651	miR-106a,(miR106b) microRNA binds CNOT6L mRNA	yes	reactome/R-HSA-8948651.md	miR-106a,(miR106b) microRNA binds CNOT6L mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	159	R-HSA-9011958	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	yes	reactome/R-HSA-9011958.md	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	160	R-HSA-9012203	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	yes	reactome/R-HSA-9012203.md	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	161	R-HSA-9012208	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	yes	reactome/R-HSA-9012208.md	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	162	R-HSA-9023909	C3PO hydrolyzes cleaved passenger strand	yes	reactome/R-HSA-9023909.md	C3PO hydrolyzes cleaved passenger strand	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	163	R-HSA-9023912	AGO2 cleaves passenger strand of duplex siRNA	yes	reactome/R-HSA-9023912.md	AGO2 cleaves passenger strand of duplex siRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	164	R-HSA-9038545	miR-613 binds to the 3'UTR of the NR1H3 mRNA	yes	reactome/R-HSA-9038545.md	miR-613 binds to the 3'UTR of the NR1H3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	165	R-HSA-9618392	miR-26 binds to the 3'UTR of the ARL4C mRNA	yes	reactome/R-HSA-9618392.md	miR-26 binds to the 3'UTR of the ARL4C mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	166	R-HSA-9618486	miR-26 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9618486.md	miR-26 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	167	R-HSA-9624925	miR-33 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9624925.md	miR-33 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	168	R-HSA-9657791	miR-144 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9657791.md	miR-144 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	169	R-HSA-9759950	miR-200c-3p binds CDH11 mRNA	yes	reactome/R-HSA-9759950.md	miR-200c-3p binds CDH11 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	170	R-HSA-9768616	miR-9 binds CDH1 mRNA	yes	reactome/R-HSA-9768616.md	miR-9 binds CDH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	171	R-HSA-9768643	miR-10b binds CDH1 mRNA	yes	reactome/R-HSA-9768643.md	miR-10b binds CDH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	172	R-HSA-9768788	miR-224 binds NPAS4 mRNA	yes	reactome/R-HSA-9768788.md	miR-224 binds NPAS4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	173	R-HSA-9860139	MIR27B microRNA binds 3'UTR of TGFBR3 mRNA	yes	reactome/R-HSA-9860139.md	MIR27B microRNA binds 3'UTR of TGFBR3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	174	R-HSA-9860160	MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA	yes	reactome/R-HSA-9860160.md	MIR-Let7-a1 microRNA binds 3'UTR of TGFBR3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	175	R-HSA-9860168	MIR23B microRNA binds 3'UTR of TGFBR3 mRNA	yes	reactome/R-HSA-9860168.md	MIR23B microRNA binds 3'UTR of TGFBR3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	176	R-HSA-9924908	CD274 mRNA binds miR-93 RISC	yes	reactome/R-HSA-9924908.md	CD274 mRNA binds miR-93 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	177	R-HSA-9924921	CD274 mRNA binds miR-34 RISC	yes	reactome/R-HSA-9924921.md	CD274 mRNA binds miR-34 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	178	R-HSA-9924968	CD274 mRNA binds miR-429 RISC	yes	reactome/R-HSA-9924968.md	CD274 mRNA binds miR-429 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	179	R-HSA-9925087	CD274 mRNA binds miR-138-5p RISC	yes	reactome/R-HSA-9925087.md	CD274 mRNA binds miR-138-5p RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	180	R-HSA-9925095	CD274 mRNA binds miR-340 RISC	yes	reactome/R-HSA-9925095.md	CD274 mRNA binds miR-340 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	181	R-HSA-9925158	CD274 mRNA binds miR-152 RISC	yes	reactome/R-HSA-9925158.md	CD274 mRNA binds miR-152 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	182	R-HSA-9925159	CD274 mRNA binds miR-140 RISC	yes	reactome/R-HSA-9925159.md	CD274 mRNA binds miR-140 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	183	R-HSA-9925246	CD274 mRNA binds miR-Let7-a1 RISC	yes	reactome/R-HSA-9925246.md	CD274 mRNA binds miR-Let7-a1 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	184	R-HSA-9925270	CD274 mRNA binds miR-148a-3p RISC	yes	reactome/R-HSA-9925270.md	CD274 mRNA binds miR-148a-3p RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	185	R-HSA-9925289	CD274 mRNA binds miR-424 RISC	yes	reactome/R-HSA-9925289.md	CD274 mRNA binds miR-424 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	186	R-HSA-9925320	CD274 mRNA binds miR-142-5p RISC	yes	reactome/R-HSA-9925320.md	CD274 mRNA binds miR-142-5p RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO2	genes/human/AGO2/AGO2-ai-review.yaml	AGO2	Q9UKV8	NCBITaxon:9606	Homo sapiens	187	R-HSA-9925324	CD274 mRNA binds miR-200B/C RISC	yes	reactome/R-HSA-9925324.md	CD274 mRNA binds miR-200B/C RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome source places AGO2 in the cytosol in this RNA-regulatory context.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	53	R-HSA-1606561	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606561.md	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	54	R-HSA-1606682	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606682.md	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	55	R-HSA-1912362	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912362.md	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	56	R-HSA-1912363	MIR200B/C microRNAs bind NOTCH1 mRNA	yes	reactome/R-HSA-1912363.md	MIR200B/C microRNAs bind NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	57	R-HSA-1912364	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912364.md	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	58	R-HSA-1912366	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912366.md	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	59	R-HSA-1912367	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	yes	reactome/R-HSA-1912367.md	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	60	R-HSA-1912368	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912368.md	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	61	R-HSA-1912406	p53 positively regulates transcription of MIR34 microRNAs	yes	reactome/R-HSA-1912406.md	p53 positively regulates transcription of MIR34 microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	62	R-HSA-2318752	miR-26A microRNAs bind PTEN mRNA	yes	reactome/R-HSA-2318752.md	miR-26A microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	63	R-HSA-3209151	miR-24 binds p16INK4A and p14ARF mRNAs	yes	reactome/R-HSA-3209151.md	miR-24 binds p16INK4A and p14ARF mRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	64	R-HSA-426489	RISC binds inexactly matching target RNAs	yes	reactome/R-HSA-426489.md	RISC binds inexactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	65	R-HSA-426522	Nonendonucleolytic RISC binds exactly matching target RNAs	yes	reactome/R-HSA-426522.md	Nonendonucleolytic RISC binds exactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	66	R-HSA-4518575	miR-92b binds 3'UTR of NLK mRNA	yes	reactome/R-HSA-4518575.md	miR-92b binds 3'UTR of NLK mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	67	R-HSA-5687103	FOXO3 regulates MIR34B,C expression	yes	reactome/R-HSA-5687103.md	FOXO3 regulates MIR34B,C expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	68	R-HSA-8935766	miR-378 binds RUNX1 mRNA	yes	reactome/R-HSA-8935766.md	miR-378 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	69	R-HSA-8937097	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	yes	reactome/R-HSA-8937097.md	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	70	R-HSA-8937134	miR-27a binds RUNX1 mRNA	yes	reactome/R-HSA-8937134.md	miR-27a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	71	R-HSA-8938440	miR-17 binds RUNX1 mRNA	yes	reactome/R-HSA-8938440.md	miR-17 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	72	R-HSA-8938487	miR-20a binds RUNX1 mRNA	yes	reactome/R-HSA-8938487.md	miR-20a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	73	R-HSA-8938507	miR-106a binds RUNX1 mRNA	yes	reactome/R-HSA-8938507.md	miR-106a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	74	R-HSA-8944650	miR-214 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944650.md	miR-214 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	75	R-HSA-8944684	miR-205 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944684.md	miR-205 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	76	R-HSA-8944706	miR-21 nonendonucleolytic RISC binds PTEN mRNA	yes	reactome/R-HSA-8944706.md	miR-21 nonendonucleolytic RISC binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	77	R-HSA-9011958	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	yes	reactome/R-HSA-9011958.md	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	78	R-HSA-9012203	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	yes	reactome/R-HSA-9012203.md	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	79	R-HSA-9012208	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	yes	reactome/R-HSA-9012208.md	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	80	R-HSA-9038545	miR-613 binds to the 3'UTR of the NR1H3 mRNA	yes	reactome/R-HSA-9038545.md	miR-613 binds to the 3'UTR of the NR1H3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	81	R-HSA-9618392	miR-26 binds to the 3'UTR of the ARL4C mRNA	yes	reactome/R-HSA-9618392.md	miR-26 binds to the 3'UTR of the ARL4C mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	82	R-HSA-9618486	miR-26 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9618486.md	miR-26 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	83	R-HSA-9624925	miR-33 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9624925.md	miR-33 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	84	R-HSA-9657791	miR-144 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9657791.md	miR-144 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	85	R-HSA-9858289	MITF-M-dependent miR-211 expression	yes	reactome/R-HSA-9858289.md	MITF-M-dependent miR-211 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	86	R-HSA-9858309	miR-211 RISC binds POU3F2 mRNA	yes	reactome/R-HSA-9858309.md	miR-211 RISC binds POU3F2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	87	R-HSA-9924921	CD274 mRNA binds miR-34 RISC	yes	reactome/R-HSA-9924921.md	CD274 mRNA binds miR-34 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	88	R-HSA-9925095	CD274 mRNA binds miR-340 RISC	yes	reactome/R-HSA-9925095.md	CD274 mRNA binds miR-340 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	89	R-HSA-9925158	CD274 mRNA binds miR-152 RISC	yes	reactome/R-HSA-9925158.md	CD274 mRNA binds miR-152 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	90	R-HSA-9925159	CD274 mRNA binds miR-140 RISC	yes	reactome/R-HSA-9925159.md	CD274 mRNA binds miR-140 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO3	genes/human/AGO3/AGO3-ai-review.yaml	AGO3	Q9H9G7	NCBITaxon:9606	Homo sapiens	91	R-HSA-9925324	CD274 mRNA binds miR-200B/C RISC	yes	reactome/R-HSA-9925324.md	CD274 mRNA binds miR-200B/C RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO3 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	43	R-HSA-1606561	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606561.md	MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	44	R-HSA-1606682	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	yes	reactome/R-HSA-1606682.md	MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	45	R-HSA-1912362	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912362.md	MIR150 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	46	R-HSA-1912363	MIR200B/C microRNAs bind NOTCH1 mRNA	yes	reactome/R-HSA-1912363.md	MIR200B/C microRNAs bind NOTCH1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	47	R-HSA-1912364	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912364.md	MIR181C microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	48	R-HSA-1912366	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	yes	reactome/R-HSA-1912366.md	MIR206 microRNA binds 3'UTR of NOTCH3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	49	R-HSA-1912367	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	yes	reactome/R-HSA-1912367.md	MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	50	R-HSA-1912368	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	yes	reactome/R-HSA-1912368.md	MIR302A microRNA binds 3'UTR of NOTCH4 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	51	R-HSA-1912406	p53 positively regulates transcription of MIR34 microRNAs	yes	reactome/R-HSA-1912406.md	p53 positively regulates transcription of MIR34 microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	52	R-HSA-2318752	miR-26A microRNAs bind PTEN mRNA	yes	reactome/R-HSA-2318752.md	miR-26A microRNAs bind PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	53	R-HSA-3209151	miR-24 binds p16INK4A and p14ARF mRNAs	yes	reactome/R-HSA-3209151.md	miR-24 binds p16INK4A and p14ARF mRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	54	R-HSA-426489	RISC binds inexactly matching target RNAs	yes	reactome/R-HSA-426489.md	RISC binds inexactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	55	R-HSA-426522	Nonendonucleolytic RISC binds exactly matching target RNAs	yes	reactome/R-HSA-426522.md	Nonendonucleolytic RISC binds exactly matching target RNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	56	R-HSA-4518575	miR-92b binds 3'UTR of NLK mRNA	yes	reactome/R-HSA-4518575.md	miR-92b binds 3'UTR of NLK mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	57	R-HSA-5687103	FOXO3 regulates MIR34B,C expression	yes	reactome/R-HSA-5687103.md	FOXO3 regulates MIR34B,C expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	58	R-HSA-8935766	miR-378 binds RUNX1 mRNA	yes	reactome/R-HSA-8935766.md	miR-378 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	59	R-HSA-8937097	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	yes	reactome/R-HSA-8937097.md	MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	60	R-HSA-8937134	miR-27a binds RUNX1 mRNA	yes	reactome/R-HSA-8937134.md	miR-27a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	61	R-HSA-8938440	miR-17 binds RUNX1 mRNA	yes	reactome/R-HSA-8938440.md	miR-17 binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	62	R-HSA-8938487	miR-20a binds RUNX1 mRNA	yes	reactome/R-HSA-8938487.md	miR-20a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	63	R-HSA-8938507	miR-106a binds RUNX1 mRNA	yes	reactome/R-HSA-8938507.md	miR-106a binds RUNX1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	64	R-HSA-8944650	miR-214 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944650.md	miR-214 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	65	R-HSA-8944684	miR-205 microRNA binds PTEN mRNA	yes	reactome/R-HSA-8944684.md	miR-205 microRNA binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	66	R-HSA-8944706	miR-21 nonendonucleolytic RISC binds PTEN mRNA	yes	reactome/R-HSA-8944706.md	miR-21 nonendonucleolytic RISC binds PTEN mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	67	R-HSA-9011958	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	yes	reactome/R-HSA-9011958.md	miR-26A and B bind to the 3'UTR of the GREB1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	68	R-HSA-9012203	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	yes	reactome/R-HSA-9012203.md	miR-26A and B bind to the 3'UTR of the CHD11 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	69	R-HSA-9012208	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	yes	reactome/R-HSA-9012208.md	miR-26A and B bind to the 3'UTR of the KPNA2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	70	R-HSA-9038545	miR-613 binds to the 3'UTR of the NR1H3 mRNA	yes	reactome/R-HSA-9038545.md	miR-613 binds to the 3'UTR of the NR1H3 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	71	R-HSA-9618392	miR-26 binds to the 3'UTR of the ARL4C mRNA	yes	reactome/R-HSA-9618392.md	miR-26 binds to the 3'UTR of the ARL4C mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	72	R-HSA-9618486	miR-26 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9618486.md	miR-26 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	73	R-HSA-9624925	miR-33 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9624925.md	miR-33 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	74	R-HSA-9657791	miR-144 binds to the 3'UTR of the ABCA1 mRNA	yes	reactome/R-HSA-9657791.md	miR-144 binds to the 3'UTR of the ABCA1 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	75	R-HSA-9858289	MITF-M-dependent miR-211 expression	yes	reactome/R-HSA-9858289.md	MITF-M-dependent miR-211 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	76	R-HSA-9858309	miR-211 RISC binds POU3F2 mRNA	yes	reactome/R-HSA-9858309.md	miR-211 RISC binds POU3F2 mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	77	R-HSA-9924921	CD274 mRNA binds miR-34 RISC	yes	reactome/R-HSA-9924921.md	CD274 mRNA binds miR-34 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	78	R-HSA-9925095	CD274 mRNA binds miR-340 RISC	yes	reactome/R-HSA-9925095.md	CD274 mRNA binds miR-340 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	79	R-HSA-9925158	CD274 mRNA binds miR-152 RISC	yes	reactome/R-HSA-9925158.md	CD274 mRNA binds miR-152 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	80	R-HSA-9925159	CD274 mRNA binds miR-140 RISC	yes	reactome/R-HSA-9925159.md	CD274 mRNA binds miR-140 RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGO4	genes/human/AGO4/AGO4-ai-review.yaml	AGO4	Q9HCK5	NCBITaxon:9606	Homo sapiens	81	R-HSA-9925324	CD274 mRNA binds miR-200B/C RISC	yes	reactome/R-HSA-9925324.md	CD274 mRNA binds miR-200B/C RISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with AGO4 as a small-RNA-loaded Argonaute/RISC effector.
human	AGPAT2	genes/human/AGPAT2/AGPAT2-ai-review.yaml	AGPAT2	O15120	NCBITaxon:9606	Homo sapiens	12	R-HSA-1483166	Synthesis of PA	yes	reactome/R-HSA-1483166.md	Synthesis of PA	Homo sapiens	GO:0006654	phosphatidic acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome places AGPAT2 in the PA-synthesis pathway.
human	AGPAT2	genes/human/AGPAT2/AGPAT2-ai-review.yaml	AGPAT2	O15120	NCBITaxon:9606	Homo sapiens	14	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome assigns AGPAT2 to the LPA-to-PA acylation reaction.
human	AGPAT2	genes/human/AGPAT2/AGPAT2-ai-review.yaml	AGPAT2	O15120	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	Reactome models AGPAT2 at the plasma membrane after specific-granule exocytosis.
human	AGPAT2	genes/human/AGPAT2/AGPAT2-ai-review.yaml	AGPAT2	O15120	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		UNDECIDED	Reactome explicitly includes AGPAT2 among specific-granule membrane proteins.
human	AGPAT2	genes/human/AGPAT2/AGPAT2-ai-review.yaml	AGPAT2	O15120	NCBITaxon:9606	Homo sapiens	24	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The curated LPA-acylation reaction occurs at the ER membrane.
human	AGPS	genes/human/AGPS/AGPS-ai-review.yaml	AGPS	O00116	NCBITaxon:9606	Homo sapiens	19	R-HSA-9033232	PEX7 binds cargo proteins containing PTS2	yes	reactome/R-HSA-9033232.md	PEX7 binds cargo proteins containing PTS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic AGPS is a precursor cargo for PEX7-dependent import.
human	AGPS	genes/human/AGPS/AGPS-ai-review.yaml	AGPS	O00116	NCBITaxon:9606	Homo sapiens	20	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The import reaction includes the cytosolic precursor stage.
human	AGPS	genes/human/AGPS/AGPS-ai-review.yaml	AGPS	O00116	NCBITaxon:9606	Homo sapiens	21	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Human AGPS reaches the peroxisomal matrix through PTS2 import.
human	AGPS	genes/human/AGPS/AGPS-ai-review.yaml	AGPS	O00116	NCBITaxon:9606	Homo sapiens	24	R-HSA-390427	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate	yes	reactome/R-HSA-390427.md	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	The ether-bond-forming reaction occurs on the luminal side of the peroxisome.
human	AGPS	genes/human/AGPS/AGPS-ai-review.yaml	AGPS	O00116	NCBITaxon:9606	Homo sapiens	25	R-HSA-75879	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	yes	reactome/R-HSA-75879.md	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	The GNPAT-associated AGPS pool is peroxisomal.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	27	R-HSA-2467665	AGRN binds Beta amyloid fibril via GAG chains	yes	reactome/R-HSA-2467665.md	AGRN binds Beta amyloid fibril via GAG chains	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Agrin is an extracellular ligand and matrix component.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	28	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Agrin is an extracellular ligand and matrix component.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	29	R-NUL-2467431	Agrin binds Integrin alphaVbeta1	yes	reactome/R-NUL-2467431.md	Agrin binds Integrin alphaVbeta1 (alpha1beta1)	Gallus gallus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Agrin is an extracellular ligand and matrix component.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	30	R-HSA-1667005	Heparanase cleaves heparan sulfate from proteoglycan in lysosome	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		UNDECIDED	The cited heparanase event resolves a lysosomal step, not this Golgi location.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	31	R-HSA-1878002	XYLTs transfer Xyl to core protein	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	32	R-HSA-1889955	B3GAT dimers transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	33	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	34	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	35	R-HSA-2022851	EXT1:EXT2 transfers GlcNAc to the heparan chain	yes	reactome/R-HSA-2022851.md	EXT1:EXT2 transfers GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	36	R-HSA-2022856	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2022856.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	37	R-HSA-2022860	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	yes	reactome/R-HSA-2022860.md	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	38	R-HSA-2022887	NDST1-4 N-deacetylates GlcNAc residues in heparan	yes	reactome/R-HSA-2022887.md	NDST1-4 N-deacetylates GlcNAc residues in heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	39	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	40	R-HSA-2076383	HS3ST1 sulfates GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076383.md	HS3ST1 sulfates GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	41	R-HSA-2076392	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2076392.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	42	R-HSA-2076419	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	yes	reactome/R-HSA-2076419.md	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	43	R-HSA-2076508	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	yes	reactome/R-HSA-2076508.md	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	44	R-HSA-2076611	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076611.md	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	45	R-HSA-3560802	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	46	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	47	R-HSA-3656254	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656254.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	48	R-HSA-3656257	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656257.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	49	R-HSA-3656261	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656261.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	50	R-HSA-3656267	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656267.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	51	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	52	R-HSA-9036285	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036285.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	53	R-HSA-9036289	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036289.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	54	R-HSA-9940993	PXYLP1 dephosphorylates Xyl moiety	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	55	R-HSA-9941039	FAM20B phosphorylates Xyl moiety	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	56	R-HSA-9953259	EXTL3 dimer transfers GlcNAc to the GAG linker	yes	reactome/R-HSA-9953259.md	EXTL3 dimer transfers GlcNAc to the GAG linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi transit accompanies agrin glycan maturation and secretion.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	57	R-HSA-1678694	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	yes	reactome/R-HSA-1678694.md	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	58	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	59	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	60	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	61	R-HSA-2423785	CR:atREs binds apoE and HSPG	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	62	R-HSA-2429643	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	63	R-HSA-9694579	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	yes	reactome/R-HSA-9694579.md	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	64	R-HSA-9694661	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9694661.md	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	65	R-HSA-9698988	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	yes	reactome/R-HSA-9698988.md	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	66	R-HSA-9699007	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9699007.md	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	67	R-HSA-9836899	sG binds to HSPGs	yes	reactome/R-HSA-9836899.md	sG binds to HSPGs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Agrin has a physiological cell-surface pool.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	68	R-HSA-1667005	Heparanase cleaves heparan sulfate from proteoglycan in lysosome	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Agrin can enter the lysosomal compartment during turnover.
human	AGRN	genes/human/AGRN/AGRN-ai-review.yaml	AGRN	O00468	NCBITaxon:9606	Homo sapiens	69	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Agrin can enter the lysosomal compartment during turnover.
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	21	R-HSA-1989774	Expression of AGT	yes	reactome/R-HSA-1989774.md	Expression of AGT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-1989774, ""Expression of AGT""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	22	R-HSA-2022403	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	yes	reactome/R-HSA-2022403.md	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022403, ""Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	23	R-HSA-2022412	Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	yes	reactome/R-HSA-2022412.md	Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022412, ""Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	24	R-HSA-2065357	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))	yes	reactome/R-HSA-2065357.md	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2065357, ""Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	25	R-HSA-2022368	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)	yes	reactome/R-HSA-2022368.md	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022368, ""MME:Zn2+ (Neprilysin) hydrolyses AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7)""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	26	R-HSA-2022378	ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))	yes	reactome/R-HSA-2022378.md	ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022378, ""ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	27	R-HSA-2022379	ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))	yes	reactome/R-HSA-2022379.md	ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022379, ""ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	28	R-HSA-2022381	Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	yes	reactome/R-HSA-2022381.md	Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022381, ""Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	29	R-HSA-2022383	Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	yes	reactome/R-HSA-2022383.md	Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022383, ""Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	30	R-HSA-2022396	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))	yes	reactome/R-HSA-2022396.md	MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022396, ""MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	31	R-HSA-2022398	ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7))	yes	reactome/R-HSA-2022398.md	ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022398, ""ACE:Zn2+ hydrolyzes AGT(25-33) (Angiotensin-(1-9)) to AGT(25-31) (Angiotensin-(1-7))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	32	R-HSA-2022399	ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))	yes	reactome/R-HSA-2022399.md	ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022399, ""ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	33	R-HSA-2022405	ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	yes	reactome/R-HSA-2022405.md	ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022405, ""ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	34	R-HSA-2022411	Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	yes	reactome/R-HSA-2022411.md	Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2022411, ""Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	35	R-HSA-2028294	Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))	yes	reactome/R-HSA-2028294.md	Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2028294, ""Mast Cell Carboxypeptidase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	36	R-HSA-2065355	Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	yes	reactome/R-HSA-2065355.md	Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-2065355, ""Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	37	R-HSA-374173	AGT(25-32) binds to AGTR1	yes	reactome/R-HSA-374173.md	AGT(25-32) binds to AGTR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-374173, ""AGT(25-32) binds to AGTR1""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	38	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-379048, ""Liganded Gq/11-activating GPCRs act as GEFs for Gq/11""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	39	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-380073, ""Liganded Gi-activating GPCR acts as a GEF for Gi""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	40	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-749448, ""Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	41	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-749452, ""The Ligand:GPCR:Gq complex dissociates""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	42	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-749454, ""The Ligand:GPCR:Gi complex dissociates""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	43	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-749456, ""Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	44	R-HSA-9615348	AGT(25-32) binds to AGTR2	yes	reactome/R-HSA-9615348.md	AGT(25-32) binds to AGTR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-9615348, ""AGT(25-32) binds to AGTR2""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	45	R-HSA-9944473	AGT(25-31) is decarboxylated to yield Alamandine	yes	reactome/R-HSA-9944473.md	AGT(25-31) is decarboxylated to yield Alamandine	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-9944473, ""AGT(25-31) is decarboxylated to yield Alamandine""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	46	R-HSA-9944540	AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)	yes	reactome/R-HSA-9944540.md	AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-HSA-9944540, ""AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A)""."
human	AGT	genes/human/AGT/AGT-ai-review.yaml	AGT	P01019	NCBITaxon:9606	Homo sapiens	47	R-NUL-2022369	ANPEP hydrolyzes Angiotensin III to Angiotensin IV	yes	reactome/R-NUL-2022369.md	ANPEP hydrolyzes Angiotensin III to Angiotensin IV	Oryctolagus cuniculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"One of 27 Reactome TAS rows on this gene, all asserting the same term - located_in extracellular region - and differing only in which reaction is cited. Together they are 24% of AGT's entire GOA record expressing a single correct claim once per reaction the protein or one of its peptides participates in. This row cites Reactome:R-NUL-2022369, ""ANPEP hydrolyzes Angiotensin III to Angiotensin IV""."
human	AGXT	genes/human/AGXT/AGXT-ai-review.yaml	AGXT	P21549	NCBITaxon:9606	Homo sapiens	31	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome represents AGXT cargo before import into the peroxisomal matrix.
human	AGXT	genes/human/AGXT/AGXT-ai-review.yaml	AGXT	P21549	NCBITaxon:9606	Homo sapiens	32	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The PEX5 cargo-docking event represents a pre-import cytosolic AGXT pool.
human	AGXT	genes/human/AGXT/AGXT-ai-review.yaml	AGXT	P21549	NCBITaxon:9606	Homo sapiens	35	R-HSA-389684	glyoxylate + alanine => glycine + pyruvate [peroxisome]	yes	reactome/R-HSA-389684.md	glyoxylate + alanine => glycine + pyruvate [peroxisome]	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	The Reactome glyoxylate-transamination event places active AGXT in the peroxisomal matrix.
human	AGXT	genes/human/AGXT/AGXT-ai-review.yaml	AGXT	P21549	NCBITaxon:9606	Homo sapiens	36	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	The PEX5 cargo-translocation model terminates in the peroxisomal matrix.
human	AGXT2	genes/human/AGXT2/AGXT2-ai-review.yaml	AGXT2	Q9BYV1	NCBITaxon:9606	Homo sapiens	23	R-HSA-904864	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate	yes	reactome/R-HSA-904864.md	Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement localizing the AGXT2 transamination reaction to the mitochondrial matrix. Consistent with the enzyme being a soluble matrix aminotransferase.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	17	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	18	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	19	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	20	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	21	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	22	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	23	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	24	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	25	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	26	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	27	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	28	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	29	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	30	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	31	R-HSA-9615901	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex	yes	reactome/R-HSA-9615901.md	AHCTF1 (ELYS) binds chromatin and Nup107-Nup160 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	The Reactome event is highly relevant to AHCTF1 function, but the propagated cytosol location is over-annotated.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	32	R-HSA-9618378	POM121 binds the Nup107-Nup160 complex	yes	reactome/R-HSA-9618378.md	POM121 binds the Nup107-Nup160 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This downstream NPC-assembly Reactome event does not support cytosol localization for AHCTF1.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	33	R-HSA-9634169	POM121 and NDC1 bind the Nup93 complex	yes	reactome/R-HSA-9634169.md	POM121 and NDC1 bind the Nup93 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This downstream NPC-assembly Reactome event does not support cytosol localization for AHCTF1.
human	AHCTF1	genes/human/AHCTF1/AHCTF1-ai-review.yaml	AHCTF1	Q8WYP5	NCBITaxon:9606	Homo sapiens	34	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome-derived cytosol annotation is not an informative AHCTF1 cellular-component call.
human	AHCY	genes/human/AHCY/AHCY-ai-review.yaml	AHCY	P23526	NCBITaxon:9606	Homo sapiens	21	R-HSA-5579084	Defective AHCY does not hydrolyse AdoHcy	yes	reactome/R-HSA-5579084.md	Defective AHCY does not hydrolyse AdoHcy	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The disease Reactome event explicitly describes AHCY as cytosolic.
human	AHCY	genes/human/AHCY/AHCY-ai-review.yaml	AHCY	P23526	NCBITaxon:9606	Homo sapiens	24	R-HSA-174401	AHCY:NAD+ tetramer hydrolyses AdoHcy	yes	reactome/R-HSA-174401.md	AHCY:NAD+ tetramer hydrolyses AdoHcy	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The normal Reactome SAH hydrolysis event places the AHCY tetramer in the cytosol.
human	AHI1	genes/human/AHI1/AHI1-ai-review.yaml	AHI1	Q8N157	NCBITaxon:9606	Homo sapiens	11	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is compatible with AHI1-containing ciliary-base assemblies.
human	AHI1	genes/human/AHI1/AHI1-ai-review.yaml	AHI1	Q8N157	NCBITaxon:9606	Homo sapiens	12	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is compatible with AHI1-containing ciliary-base assemblies.
human	AHI1	genes/human/AHI1/AHI1-ai-review.yaml	AHI1	Q8N157	NCBITaxon:9606	Homo sapiens	13	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is compatible with AHI1-containing ciliary-base assemblies.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	25	R-HSA-8937144	Aryl hydrocarbon receptor signalling	yes	reactome/R-HSA-8937144.md	Aryl hydrocarbon receptor signalling	Homo sapiens	GO:0006805	xenobiotic metabolic process	TAS	involved_in	BP	false		ACCEPT	xenobiotic metabolic process is a core AHR pathway outcome. AHR binds xenobiotic ligands such as TCDD/dioxin-related compounds and induces detoxification and response genes.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	27	R-HSA-8936849	AHR:2xHSP90:AIP:PTGES3 binds TCDD	yes	reactome/R-HSA-8936849.md	AHR:2xHSP90:AIP:PTGES3 binds TCDD	Homo sapiens	GO:0004879	nuclear receptor activity	TAS	enables	MF	false		ACCEPT	AHR is a ligand-activated intracellular receptor/transcription factor. Ligand binding, nuclear translocation, ARNT heterodimerization, and target-gene activation are all well supported.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	28	R-HSA-8937191	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	yes	reactome/R-HSA-8937191.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	Homo sapiens	GO:0004879	nuclear receptor activity	TAS	enables	MF	false		ACCEPT	AHR is a ligand-activated intracellular receptor/transcription factor. Ligand binding, nuclear translocation, ARNT heterodimerization, and target-gene activation are all well supported.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	69	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is consistent with AHR biology: inactive AHR is predominantly cytoplasmic/cytosolic in a chaperone complex and ligand activation drives nuclear/nucleoplasmic accumulation and chromatin-associated transcriptional activity.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	70	R-HSA-8937177	AHR:TCDD binds ARNT	yes	reactome/R-HSA-8937177.md	AHR:TCDD binds ARNT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is consistent with AHR biology: inactive AHR is predominantly cytoplasmic/cytosolic in a chaperone complex and ligand activation drives nuclear/nucleoplasmic accumulation and chromatin-associated transcriptional activity.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	71	R-HSA-8937191	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	yes	reactome/R-HSA-8937191.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is consistent with AHR biology: inactive AHR is predominantly cytoplasmic/cytosolic in a chaperone complex and ligand activation drives nuclear/nucleoplasmic accumulation and chromatin-associated transcriptional activity.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	72	R-HSA-8936849	AHR:2xHSP90:AIP:PTGES3 binds TCDD	yes	reactome/R-HSA-8936849.md	AHR:2xHSP90:AIP:PTGES3 binds TCDD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with AHR biology: inactive AHR is predominantly cytoplasmic/cytosolic in a chaperone complex and ligand activation drives nuclear/nucleoplasmic accumulation and chromatin-associated transcriptional activity.
human	AHR	genes/human/AHR/AHR-ai-review.yaml	AHR	P35869	NCBITaxon:9606	Homo sapiens	73	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with AHR biology: inactive AHR is predominantly cytoplasmic/cytosolic in a chaperone complex and ligand activation drives nuclear/nucleoplasmic accumulation and chromatin-associated transcriptional activity.
human	AIFM2	genes/human/AIFM2/AIFM2-ai-review.yaml	AIFM2	Q9BRQ8	NCBITaxon:9606	Homo sapiens	44	R-HSA-6791306	TP53 stimulates AIFM2 gene expression	yes	reactome/R-HSA-6791306.md	TP53 stimulates AIFM2 gene expression	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome annotation relates to TP53-mediated AIFM2 transcription in the context of cytochrome C release. The mitochondrial outer membrane localization derives from the original AMID characterization, but FSP1's primary functional location is now known to be plasma membrane and lipid droplets.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	34	R-HSA-379861	glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate	yes	reactome/R-HSA-379861.md	glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The glutamate-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	35	R-HSA-379865	proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate	yes	reactome/R-HSA-379865.md	proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The proline-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	36	R-HSA-379867	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate	yes	reactome/R-HSA-379867.md	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The aspartate-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	37	R-HSA-379893	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate	yes	reactome/R-HSA-379893.md	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The isoleucine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	38	R-HSA-379974	leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate	yes	reactome/R-HSA-379974.md	leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The leucine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	39	R-HSA-379982	glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate	yes	reactome/R-HSA-379982.md	glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The glutamine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	40	R-HSA-379993	arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate	yes	reactome/R-HSA-379993.md	arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The arginine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	41	R-HSA-379994	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate	yes	reactome/R-HSA-379994.md	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The methionine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	42	R-HSA-380008	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate	yes	reactome/R-HSA-380008.md	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The lysine-charging event places AIMP1 in the cytosolic synthetase complex.
human	AIMP1	genes/human/AIMP1/AIMP1-ai-review.yaml	AIMP1	Q12904	NCBITaxon:9606	Homo sapiens	43	R-HSA-9825759	MAPK-dependent phosphorylation of KARS	yes	reactome/R-HSA-9825759.md	MAPK-dependent phosphorylation of KARS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The KARS phosphorylation event includes the cytosolic AIMP1-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	42	R-HSA-379861	Glutamate-tRNA ligation	yes	reactome/R-HSA-379861.md	glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	43	R-HSA-379865	Proline-tRNA ligation	yes	reactome/R-HSA-379865.md	proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	44	R-HSA-379867	Aspartate-tRNA ligation	yes	reactome/R-HSA-379867.md	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	45	R-HSA-379893	Isoleucine-tRNA ligation	yes	reactome/R-HSA-379893.md	isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	46	R-HSA-379974	Leucine-tRNA ligation	yes	reactome/R-HSA-379974.md	leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	47	R-HSA-379982	Glutamine-tRNA ligation	yes	reactome/R-HSA-379982.md	glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	48	R-HSA-379993	Arginine-tRNA ligation	yes	reactome/R-HSA-379993.md	arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	49	R-HSA-379994	Methionine-tRNA ligation	yes	reactome/R-HSA-379994.md	methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	50	R-HSA-380008	Lysine-tRNA ligation	yes	reactome/R-HSA-380008.md	lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIMP2	genes/human/AIMP2/AIMP2-ai-review.yaml	AIMP2	Q13155	NCBITaxon:9606	Homo sapiens	51	R-HSA-9825759	MAPK-dependent phosphorylation of KARS	yes	reactome/R-HSA-9825759.md	MAPK-dependent phosphorylation of KARS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome event supports the cytosolic compartment of the AIMP2-containing complex.
human	AIP	genes/human/AIP/AIP-ai-review.yaml	AIP	O00170	NCBITaxon:9606	Homo sapiens	25	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This TAS annotation is based on Reactome pathway R-HSA-8937169 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm). In the Reactome model, the entire AHR complex including AIP translocates to the nucleus upon ligand binding. AIP is primarily cytosolic and its presence in the nucleoplasm is transient as part of the ligand-bound AHR complex before the complex dissociates. This is a non-core localization.
human	AIP	genes/human/AIP/AIP-ai-review.yaml	AIP	O00170	NCBITaxon:9606	Homo sapiens	26	R-HSA-8937191	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	yes	reactome/R-HSA-8937191.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This TAS annotation is based on Reactome pathway R-HSA-8937191 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates). This represents the dissociation of the AHR complex in the nucleoplasm after translocation. AIP is released from the complex in the nucleus. This is consistent with the transient nuclear localization of AIP during AHR signaling.
human	AIP	genes/human/AIP/AIP-ai-review.yaml	AIP	O00170	NCBITaxon:9606	Homo sapiens	27	R-HSA-8936849	AHR:2xHSP90:AIP:PTGES3 binds TCDD	yes	reactome/R-HSA-8936849.md	AHR:2xHSP90:AIP:PTGES3 binds TCDD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This TAS annotation is based on Reactome pathway R-HSA-8936849 (AHR:2xHSP90:AIP:PTGES3 binds TCDD). AIP is part of the cytosolic AHR complex that binds the TCDD ligand. Cytosolic localization of AIP is well-established.
human	AIP	genes/human/AIP/AIP-ai-review.yaml	AIP	O00170	NCBITaxon:9606	Homo sapiens	28	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This TAS annotation is based on Reactome pathway R-HSA-8937169 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm). AIP starts in the cytosol as part of the AHR complex. Cytosol is the primary localization.
human	AIP	genes/human/AIP/AIP-ai-review.yaml	AIP	O00170	NCBITaxon:9606	Homo sapiens	29	R-HSA-8950201	Expression of Aryl Hydrocarbon receptor-interacting protein	yes	reactome/R-HSA-8950201.md	Expression of Aryl Hydrocarbon receptor-interacting protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This TAS annotation is based on Reactome pathway R-HSA-8950201 (Expression of Aryl Hydrocarbon receptor-interacting protein). AIP is expressed and localized in the cytosol. This is consistent with all other evidence.
human	AK2	genes/human/AK2/AK2-ai-review.yaml	AK2	P54819	NCBITaxon:9606	Homo sapiens	18	R-HSA-110144	ADP + ADP <=> AMP + ATP [AK2]	yes	reactome/R-HSA-110144.md	ADP + ADP <=> AMP + ATP [AK2]	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	The reaction is localized to the mitochondrial intermembrane space.
human	AK2	genes/human/AK2/AK2-ai-review.yaml	AK2	P54819	NCBITaxon:9606	Homo sapiens	19	R-HSA-110145	AMP + ATP <=> ADP + ADP [AK2]	yes	reactome/R-HSA-110145.md	AMP + ATP <=> ADP + ADP [AK2]	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	The reaction is localized to the mitochondrial intermembrane space.
human	AK2	genes/human/AK2/AK2-ai-review.yaml	AK2	P54819	NCBITaxon:9606	Homo sapiens	22	R-HSA-499943	Interconversion of nucleotide di- and triphosphates	yes	reactome/R-HSA-499943.md	Interconversion of nucleotide di- and triphosphates	Homo sapiens	GO:0015949	nucleobase-containing small molecule interconversion	TAS	involved_in	BP	false		ACCEPT	Adenylate interconversion is a direct AK2 pathway step.
human	AKAP10	genes/human/AKAP10/AKAP10-ai-review.yaml	AKAP10	O43572	NCBITaxon:9606	Homo sapiens	29	R-HSA-992708	Dual-specific AKAPs bind type I and II PKA regulatory subunits	yes	reactome/R-HSA-992708.md	Dual-specific AKAPs bind type I and II PKA regulatory subunits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Sourced from a Reactome reaction whose compartment tag is a property of the reaction, not a measurement of where AKAP10 is. The provenance is weak; the term is independently established, so the row stands.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	28	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS placing AKR1C4 in retinoid metabolism, consistent with its documented retinaldehyde reductase activity (reduces retinaldehyde to retinol, IDA PMID:21851338). A real but minor, non-core metabolic role for this liver enzyme.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	29	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile-acid synthesis via 7alpha-hydroxycholesterol). This is a core biological process for AKR1C4: as the hepatic 3-alpha-hydroxysteroid dehydrogenase it reduces the 3-oxo group of the 5beta-reduced bile-acid intermediates (downstream of the AKR1D1 5beta-reductase).
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	30	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile-acid synthesis via 24-hydroxycholesterol). Same core bile-acid biosynthetic role; redundant Reactome pathway variant.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	31	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile-acid synthesis via 27-hydroxycholesterol). Same core bile-acid biosynthetic role; redundant Reactome pathway variant.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	32	R-HSA-192036	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol	yes	reactome/R-HSA-192036.md	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	33	R-HSA-192160	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol	yes	reactome/R-HSA-192160.md	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	34	R-HSA-193758	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol	yes	reactome/R-HSA-193758.md	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	35	R-HSA-193781	TODO: Fetch title	no				GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	36	R-HSA-193800	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol	yes	reactome/R-HSA-193800.md	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	37	R-HSA-193841	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol	yes	reactome/R-HSA-193841.md	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	38	R-HSA-2855252	AKRs reduce RBP2:atRAL to RBP2:atROL	yes	reactome/R-HSA-2855252.md	AKRs reduce RBP2:atRAL to RBP2:atROL	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	The broad redox or metabolic annotation accurately describes AKR1C4 catalytic function.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	56	R-HSA-192036	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol	yes	reactome/R-HSA-192036.md	5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization, consistent with the curated subcellular location. Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	57	R-HSA-192160	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol	yes	reactome/R-HSA-192160.md	5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (redundant pathway variant). Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	58	R-HSA-193758	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol	yes	reactome/R-HSA-193758.md	5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (redundant pathway variant). Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	59	R-HSA-193781	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (redundant pathway variant). Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	60	R-HSA-193800	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol	yes	reactome/R-HSA-193800.md	5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (redundant pathway variant). Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	61	R-HSA-193841	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol	yes	reactome/R-HSA-193841.md	5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (redundant pathway variant). Core localization.
human	AKR1C4	genes/human/AKR1C4/AKR1C4-ai-review.yaml	AKR1C4	P17516	NCBITaxon:9606	Homo sapiens	62	R-HSA-2855252	AKRs reduce RBP2:atRAL to RBP2:atROL	yes	reactome/R-HSA-2855252.md	AKRs reduce RBP2:atRAL to RBP2:atROL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (retinaldehyde-reduction pathway). Core localization.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	17	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	AKR1D1 contributes to bile-acid synthesis via 7alpha-hydroxycholesterol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	18	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	AKR1D1 contributes to bile-acid synthesis via 24-hydroxycholesterol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	19	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	AKR1D1 contributes to bile-acid synthesis via 27-hydroxycholesterol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	20	R-HSA-192033	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one	yes	reactome/R-HSA-192033.md	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	21	R-HSA-192067	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one	yes	reactome/R-HSA-192067.md	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	22	R-HSA-193746	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one	yes	reactome/R-HSA-193746.md	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	23	R-HSA-193755	TODO: Fetch title	no				GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	24	R-HSA-193821	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one	yes	reactome/R-HSA-193821.md	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	25	R-HSA-193824	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one	yes	reactome/R-HSA-193824.md	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one	Homo sapiens	GO:0008106	alcohol dehydrogenase (NADP+) activity	TAS	enables	MF	false		MODIFY	This Reactome reaction is steroid double-bond reduction.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	28	R-HSA-192033	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one	yes	reactome/R-HSA-192033.md	4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	29	R-HSA-192067	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one	yes	reactome/R-HSA-192067.md	4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	30	R-HSA-193746	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one	yes	reactome/R-HSA-193746.md	4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	31	R-HSA-193755	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	32	R-HSA-193821	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one	yes	reactome/R-HSA-193821.md	4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKR1D1	genes/human/AKR1D1/AKR1D1-ai-review.yaml	AKR1D1	P51857	NCBITaxon:9606	Homo sapiens	33	R-HSA-193824	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one	yes	reactome/R-HSA-193824.md	4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The steroid reduction reaction places AKR1D1 in cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	107	R-HSA-9607240	FLT3 Signaling	yes	reactome/R-HSA-9607240.md	FLT3 Signaling	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	FLT3-ligand signaling activates the PI3K–AKT pathway, with AKT-catalyzed FOXO3 phosphorylation represented as a downstream step.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	108	R-HSA-389356	Co-stimulation by CD28	yes	reactome/R-HSA-389356.md	Co-stimulation by CD28	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	CD28 costimulation engages the PI3K–AKT signaling branch in T cells; the constituent event models AKT phosphorylation of MAP3K8/Cot.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	109	R-HSA-2262752	Cellular responses to stress	yes	reactome/R-HSA-2262752.md	Cellular responses to stress	Homo sapiens	GO:0033554	cellular response to stress	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	The stress-response pathway includes an AKT–ESR1 signaling branch responding to mitochondrial protein-folding stress, alongside other stress pathways.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	110	R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	yes	reactome/R-HSA-450385.md	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	Homo sapiens	GO:0043488	regulation of mRNA stability	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	AKT1 phosphorylates ZFP36L1/BRF1, permitting its sequestration by 14-3-3 and inhibiting its mRNA-destabilizing activity.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	111	R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA	yes	reactome/R-HSA-450604.md	KSRP (KHSRP) binds and destabilizes mRNA	Homo sapiens	GO:0043488	regulation of mRNA stability	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	AKT phosphorylation of KHSRP at Ser193 inhibits its mRNA-destabilizing activity and promotes 14-3-3-dependent nuclear retention.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	112	R-HSA-198599	AKT phosphorylates MDM2	yes	reactome/R-HSA-198599.md	AKT phosphorylates MDM2	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates MDM2 at Ser166 and Ser188 in the cytosol, regulating MDM2 stability and subsequent signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	113	R-HSA-198609	AKT phosphorylates TSC2, inhibiting it	yes	reactome/R-HSA-198609.md	AKT phosphorylates TSC2, inhibiting it	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates TSC2 at Ser939 and Thr1462 in the cytosol, inhibiting the TSC regulatory branch upstream of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	114	R-HSA-198611	AKT phosphorylates IKKalpha	yes	reactome/R-HSA-198611.md	AKT phosphorylates IKKalpha	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates the IKK subunit CHUK at Thr23 in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	115	R-HSA-198613	AKT phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-198613.md	AKT phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates the cell-cycle inhibitors CDKN1A and CDKN1B in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	116	R-HSA-198621	AKT phosphorylates caspase-9	yes	reactome/R-HSA-198621.md	AKT phosphorylates caspase-9	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates caspase-9 at Ser196 in the cytosol, inhibiting this apoptotic protease.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	117	R-HSA-199298	AKT phosphorylates CREB1	yes	reactome/R-HSA-199298.md	AKT phosphorylates CREB1	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates CREB1 at Ser133 in the nucleoplasm, linking PI3K signaling to CREB-dependent transcription.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	118	R-HSA-199299	AKT phosphorylates FOXO transcription factors	yes	reactome/R-HSA-199299.md	AKT phosphorylates FOXO transcription factors	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	Nuclear AKT phosphorylates FOXO1, FOXO3 and FOXO4 at defined serine/threonine sites; the event explicitly distinguishes the less certain FOXO6 inference.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	119	R-HSA-199839	AKT can phosphorylate RSK	yes	reactome/R-HSA-199839.md	AKT can phosphorylate RSK	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	The event models AKT phosphorylation of RPS6KB2 in the nucleoplasm; this is the nuclear S6 kinase substrate, not a transfer of its activity to AKT.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	120	R-HSA-199863	AKT can phosphorylate NR4A1 (NUR77)	yes	reactome/R-HSA-199863.md	AKT can phosphorylate NR4A1 (NUR77)	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	The event models nuclear AKT phosphorylation of NR4A1 but explicitly notes subsequent work favoring RSK/MSK as the physiological NR4A1 kinase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	121	R-HSA-200143	AKT phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-200143.md	AKT phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT phosphorylates AKT1S1/PRAS40 in the cytosol, relieving its inhibition of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	122	R-HSA-8948757	AKT phosphorylates MKRN1	yes	reactome/R-HSA-8948757.md	AKT phosphorylates MKRN1	Homo sapiens	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	AKT1 phosphorylates cytosolic MKRN1 at Ser109, stabilizing this ubiquitin ligase in an EGF-responsive regulatory circuit.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	123	R-HSA-9604328	AKT1 phosphorylates NOTCH4	yes	reactome/R-HSA-9604328.md	AKT1 phosphorylates NOTCH4	Homo sapiens	GO:0045746	negative regulation of Notch signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Recombinant human AKT1 phosphorylates human NOTCH4 intracellular domain at four serines; the model places this inhibitory Notch-regulatory step in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	124	R-HSA-203615	eNOS activation	yes	reactome/R-HSA-203615.md	eNOS activation	Homo sapiens	GO:0046209	nitric oxide metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	The eNOS-activation pathway includes AKT1-catalyzed NOS3 phosphorylation as a concrete regulatory step in nitric-oxide production.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	125	R-HSA-9856530	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	yes	reactome/R-HSA-9856530.md	High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Homo sapiens	GO:0097700	vascular endothelial cell response to laminar fluid shear stress	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Laminar shear stress activates endothelial AKT1, which phosphorylates NOS3 as a defined downstream signaling step.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	126	R-HSA-6804758	Regulation of TP53 Activity through Acetylation	yes	reactome/R-HSA-6804758.md	Regulation of TP53 Activity through Acetylation	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	AKT phosphorylates KAT6A at Thr369 within the pathway controlling TP53 acetylation; KAT6A, not AKT, performs the acetylation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	127	R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors	yes	reactome/R-HSA-6804759.md	Regulation of TP53 Activity through Association with Co-factors	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	AKT phosphorylation of PHF20 at Ser291 regulates its effect on TP53 stability, providing a defined step in the cofactor-regulation pathway.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	128	R-HSA-211163	AKT-mediated inactivation of FOXO1A	yes	reactome/R-HSA-211163.md	AKT-mediated inactivation of FOXO1A	Homo sapiens	GO:2000074	regulation of type B pancreatic cell development	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	AKT-mediated FOXO1 phosphorylation and nuclear exclusion are modeled within regulation of pancreatic beta-cell gene expression and development.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	131	R-HSA-1358791	Phosphorylation of USP8 by P-AKT	yes	reactome/R-HSA-1358791.md	Phosphorylation of USP8 by P-AKT	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates USP8 at Thr945 in the cytosol, stabilizing the USP8–NRDP1 regulatory pathway.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	132	R-HSA-198599	AKT phosphorylates MDM2	yes	reactome/R-HSA-198599.md	AKT phosphorylates MDM2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates MDM2 at Ser166 and Ser188 in the cytosol, regulating MDM2 stability and subsequent signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	133	R-HSA-198609	AKT phosphorylates TSC2, inhibiting it	yes	reactome/R-HSA-198609.md	AKT phosphorylates TSC2, inhibiting it	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates TSC2 at Ser939 and Thr1462 in the cytosol, inhibiting the TSC regulatory branch upstream of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	134	R-HSA-198611	AKT phosphorylates IKKalpha	yes	reactome/R-HSA-198611.md	AKT phosphorylates IKKalpha	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates the IKK subunit CHUK at Thr23 in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	135	R-HSA-198613	AKT phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-198613.md	AKT phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates the cell-cycle inhibitors CDKN1A and CDKN1B in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	136	R-HSA-198621	AKT phosphorylates caspase-9	yes	reactome/R-HSA-198621.md	AKT phosphorylates caspase-9	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates caspase-9 at Ser196 in the cytosol, inhibiting this apoptotic protease.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	137	R-HSA-199298	AKT phosphorylates CREB1	yes	reactome/R-HSA-199298.md	AKT phosphorylates CREB1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates CREB1 at Ser133 in the nucleoplasm, linking PI3K signaling to CREB-dependent transcription.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	138	R-HSA-199299	AKT phosphorylates FOXO transcription factors	yes	reactome/R-HSA-199299.md	AKT phosphorylates FOXO transcription factors	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Nuclear AKT phosphorylates FOXO1, FOXO3 and FOXO4 at defined serine/threonine sites; the event explicitly distinguishes the less certain FOXO6 inference.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	139	R-HSA-199839	AKT can phosphorylate RSK	yes	reactome/R-HSA-199839.md	AKT can phosphorylate RSK	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event models AKT phosphorylation of RPS6KB2 in the nucleoplasm; this is the nuclear S6 kinase substrate, not a transfer of its activity to AKT.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	140	R-HSA-199863	AKT can phosphorylate NR4A1 (NUR77)	yes	reactome/R-HSA-199863.md	AKT can phosphorylate NR4A1 (NUR77)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event models nuclear AKT phosphorylation of NR4A1 but explicitly notes subsequent work favoring RSK/MSK as the physiological NR4A1 kinase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	141	R-HSA-200143	AKT phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-200143.md	AKT phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates AKT1S1/PRAS40 in the cytosol, relieving its inhibition of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	142	R-HSA-211164	AKT phosphorylates FOXO1A	yes	reactome/R-HSA-211164.md	AKT phosphorylates FOXO1A	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT catalyzes FOXO1 phosphorylation at Thr24, Ser256 and Ser319 in the nucleoplasm.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	143	R-HSA-2399941	AKT1 E17K mutant phosphorylates BAD	yes	reactome/R-HSA-2399941.md	AKT1 E17K mutant phosphorylates BAD	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The cancer event models cytosolic AKT1 E17K phosphorylation of BAD, retaining the normal AKT serine/threonine kinase chemistry.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	144	R-HSA-2399966	AKT1 E17K mutant phosphorylates GSK3	yes	reactome/R-HSA-2399966.md	AKT1 E17K mutant phosphorylates GSK3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 E17K retains cytosolic phosphorylation of GSK3, an inhibitory modification of that substrate.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	145	R-HSA-2399969	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-2399969.md	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 E17K phosphorylates CDKN1B; extension to CDKN1A is explicitly predicted rather than experimentally tested in this event.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	146	R-HSA-2399977	AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-2399977.md	AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of PRAS40 from the established wild-type reaction; mutant-specific testing is not claimed.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	147	R-HSA-2399981	AKT1 E17K mutant phosphorylates MDM2	yes	reactome/R-HSA-2399981.md	AKT1 E17K mutant phosphorylates MDM2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of MDM2 from the established wild-type reaction; mutant-specific testing is not claimed.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	148	R-HSA-2399982	AKT1 E17K mutant phosphorylates TSC2, inhibiting it	yes	reactome/R-HSA-2399982.md	AKT1 E17K mutant phosphorylates TSC2, inhibiting it	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation and inhibition of TSC2 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	149	R-HSA-2399985	AKT1 E17K mutant phosphorylates caspase-9	yes	reactome/R-HSA-2399985.md	AKT1 E17K mutant phosphorylates caspase-9	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of caspase-9 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	150	R-HSA-2399988	AKT1 E17K mutant phosphorylates NR4A1 (NUR77)	yes	reactome/R-HSA-2399988.md	AKT1 E17K mutant phosphorylates NR4A1 (NUR77)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of NR4A1; its wild-type counterpart also records uncertainty about the physiological NR4A1 kinase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	151	R-HSA-2399992	AKT1 E17K mutant phosphorylates forkhead box transcription factors	yes	reactome/R-HSA-2399992.md	AKT1 E17K mutant phosphorylates forkhead box transcription factors	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 E17K phosphorylates FOXO3; the model extends this to other FOXO proteins with explicit experimental limitations.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	152	R-HSA-2399996	AKT1 E17K mutant phosphorylates CREB1	yes	reactome/R-HSA-2399996.md	AKT1 E17K mutant phosphorylates CREB1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of CREB1 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	153	R-HSA-2399999	AKT1 E17K mutant phosphorylates RSK	yes	reactome/R-HSA-2399999.md	AKT1 E17K mutant phosphorylates RSK	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of RPS6KB2 from the wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	154	R-HSA-2400001	AKT1 E17K mutant phosphorylates CHUK (IKKalpha)	yes	reactome/R-HSA-2400001.md	AKT1 E17K mutant phosphorylates CHUK (IKKalpha)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of CHUK from the wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	155	R-HSA-3769394	AKT phosphorylates CBY1	yes	reactome/R-HSA-3769394.md	AKT phosphorylates CBY1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1/AKT2 phosphorylates CBY1 at Ser20 in a nuclear beta-catenin complex, enabling subsequent 14-3-3-dependent export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	156	R-HSA-377186	Activated AKT phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-377186.md	Activated Akt1 phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates AKT1S1/PRAS40 at Thr246; the current model explicitly places the AKT catalyst in the cytosol and the mTORC1 substrate complex at the lysosomal membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	157	R-HSA-389756	AKT interacts and phosphorylates Cot	yes	reactome/R-HSA-389756.md	AKT interacts and phosphorylates Cot	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT interacts with MAP3K8/Cot and phosphorylates Ser400 in cytosolic assays; Reactome explicitly limits the evidence to in-vitro and overexpression conditions.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	158	R-HSA-432110	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding	yes	reactome/R-HSA-432110.md	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 can phosphorylate the integrin beta3 cytoplasmic tail at Thr779; the modeled kinase entity is at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	159	R-HSA-6805640	AKT phosphorylates KAT6A	yes	reactome/R-HSA-6805640.md	AKT phosphorylates KAT6A	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates nuclear KAT6A at Thr369, preventing association with PML and reducing KAT6A-mediated TP53 acetylation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	160	R-HSA-6805785	AKT phosphorylates PHF20	yes	reactome/R-HSA-6805785.md	AKT phosphorylates PHF20	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates PHF20 at Ser291 in the nucleoplasm, regulating damage-induced TP53 stabilization.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	161	R-HSA-8933446	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling	yes	reactome/R-HSA-8933446.md	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates DENND1A/DENND1B in the cytosol, relieving their autoinhibition and promoting RAB35 activation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	162	R-HSA-8948757	AKT phosphorylates MKRN1	yes	reactome/R-HSA-8948757.md	AKT phosphorylates MKRN1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 phosphorylates cytosolic MKRN1 at Ser109, stabilizing this ubiquitin ligase in an EGF-responsive regulatory circuit.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	163	R-HSA-9624526	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR	yes	reactome/R-HSA-9624526.md	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates FOXO3 in the nucleoplasm downstream of estrogen/EGFR signaling, promoting FOXO3 nuclear export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	164	R-HSA-9699579	AKT phosphorylates FOXO3 downstream of FLT3	yes	reactome/R-HSA-9699579.md	AKT phosphorylates FOXO3 downstream of FLT3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	AKT phosphorylates FOXO3 in the nucleoplasm downstream of FLT3 signaling, promoting FOXO3 nuclear export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	165	R-NUL-3139045	AKT phosphorylates Bad	yes	reactome/R-NUL-3139045.md	AKT phosphorylates Bad	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This mixed-species reaction uses recombinant human AKT to phosphorylate recombinant mouse Bad at Ser136; the catalyst is human and the modeled location is cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	166	R-NUL-8939977	Activated AKT1 phosphorylates Runx2	yes	reactome/R-NUL-8939977.md	Activated AKT1 phosphorylates Runx2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This mixed-species reaction uses recombinant human AKT1 to phosphorylate mouse Runx2-5 at Ser203, Thr205 and Thr207; the model places the catalyst in nucleoplasm.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	199	R-HSA-9860792	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177	yes	reactome/R-HSA-9860792.md	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177	Homo sapiens	GO:0106310	protein serine kinase activity	TAS	enables	MF	false		ACCEPT	AKT1 phosphorylates NOS3 Ser1177 at the plasma membrane during endothelial flow signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	202	R-HSA-9841244	Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species	yes	reactome/R-HSA-9841244.md	Phosphorylation of AKT1 on serine-473 in response to reactive oxygen species	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Mitochondrial folding stress causes phosphorylation of cytosolic AKT1 at Ser473; the model does not place AKT1 inside the mitochondrial intermembrane space.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	203	R-HSA-9841265	p-S473-AKT1 phosphorylates ESR1 on serine-167	yes	reactome/R-HSA-9841265.md	p-S473-AKT1 phosphorylates ESR1 on serine-167	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Activated cytosolic AKT1 phosphorylates ESR1 at Ser167 in a mitochondrial stress-response signaling branch.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	204	R-HSA-9841265	p-S473-AKT1 phosphorylates ESR1 on serine-167	yes	reactome/R-HSA-9841265.md	p-S473-AKT1 phosphorylates ESR1 on serine-167	Homo sapiens	GO:0106310	protein serine kinase activity	TAS	enables	MF	false		ACCEPT	Activated cytosolic AKT1 phosphorylates ESR1 at Ser167 in a mitochondrial stress-response signaling branch.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	280	R-HSA-8848758	PTK6 phosphorylates AKT1	yes	reactome/R-HSA-8848758.md	PTK6 phosphorylates AKT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PTK6 phosphorylates cytosolic AKT1 at Tyr315 and Tyr326; AKT1 is the tyrosine-phosphorylated substrate in this event.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	303	R-HSA-2399988	AKT1 E17K mutant phosphorylates NR4A1 (NUR77)	yes	reactome/R-HSA-2399988.md	AKT1 E17K mutant phosphorylates NR4A1 (NUR77)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of NR4A1; its wild-type counterpart also records uncertainty about the physiological NR4A1 kinase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	304	R-HSA-2399992	AKT1 E17K mutant phosphorylates forkhead box transcription factors	yes	reactome/R-HSA-2399992.md	AKT1 E17K mutant phosphorylates forkhead box transcription factors	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT1 E17K phosphorylates FOXO3; the model extends this to other FOXO proteins with explicit experimental limitations.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	305	R-HSA-2399996	AKT1 E17K mutant phosphorylates CREB1	yes	reactome/R-HSA-2399996.md	AKT1 E17K mutant phosphorylates CREB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of CREB1 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	306	R-HSA-2399997	AKT1 E17K mutant translocates to the nucleus	yes	reactome/R-HSA-2399997.md	AKT1 E17K mutant translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event predicts movement of activated AKT1 E17K from cytosol to nucleoplasm and explicitly states that this mutant-specific translocation was not directly tested.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	307	R-HSA-2399999	AKT1 E17K mutant phosphorylates RSK	yes	reactome/R-HSA-2399999.md	AKT1 E17K mutant phosphorylates RSK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event predicts nuclear AKT1 E17K phosphorylation of RPS6KB2 from the wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	308	R-HSA-2219536	AKT1 E17K mutant binds PIP2	yes	reactome/R-HSA-2219536.md	AKT1 E17K mutant binds PIP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The AKT1 E17K variant binds PIP2, moving from the cytosol to the plasma membrane with altered lipid affinity.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	309	R-HSA-2243942	PDPK1 phosphorylates AKT1 E17K mutant	yes	reactome/R-HSA-2243942.md	PDPK1 phosphorylates AKT1 E17K mutant	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event models PDPK1 phosphorylation of membrane-bound AKT1 E17K and release of active AKT1 E17K into the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	310	R-HSA-2399941	AKT1 E17K mutant phosphorylates BAD	yes	reactome/R-HSA-2399941.md	AKT1 E17K mutant phosphorylates BAD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cancer event models cytosolic AKT1 E17K phosphorylation of BAD, retaining the normal AKT serine/threonine kinase chemistry.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	311	R-HSA-2399966	AKT1 E17K mutant phosphorylates GSK3	yes	reactome/R-HSA-2399966.md	AKT1 E17K mutant phosphorylates GSK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT1 E17K retains cytosolic phosphorylation of GSK3, an inhibitory modification of that substrate.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	312	R-HSA-2399969	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-2399969.md	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT1 E17K phosphorylates CDKN1B; extension to CDKN1A is explicitly predicted rather than experimentally tested in this event.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	313	R-HSA-2399977	AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-2399977.md	AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of PRAS40 from the established wild-type reaction; mutant-specific testing is not claimed.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	314	R-HSA-2399981	AKT1 E17K mutant phosphorylates MDM2	yes	reactome/R-HSA-2399981.md	AKT1 E17K mutant phosphorylates MDM2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of MDM2 from the established wild-type reaction; mutant-specific testing is not claimed.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	315	R-HSA-2399982	AKT1 E17K mutant phosphorylates TSC2, inhibiting it	yes	reactome/R-HSA-2399982.md	AKT1 E17K mutant phosphorylates TSC2, inhibiting it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation and inhibition of TSC2 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	316	R-HSA-2399985	AKT1 E17K mutant phosphorylates caspase-9	yes	reactome/R-HSA-2399985.md	AKT1 E17K mutant phosphorylates caspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of caspase-9 from the established wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	317	R-HSA-2399997	AKT1 E17K mutant translocates to the nucleus	yes	reactome/R-HSA-2399997.md	AKT1 E17K mutant translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts movement of activated AKT1 E17K from cytosol to nucleoplasm and explicitly states that this mutant-specific translocation was not directly tested.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	318	R-HSA-2400001	AKT1 E17K mutant phosphorylates CHUK (IKKalpha)	yes	reactome/R-HSA-2400001.md	AKT1 E17K mutant phosphorylates CHUK (IKKalpha)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The event predicts cytosolic AKT1 E17K phosphorylation of CHUK from the wild-type reaction.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	319	R-HSA-2219536	AKT1 E17K mutant binds PIP2	yes	reactome/R-HSA-2219536.md	AKT1 E17K mutant binds PIP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The AKT1 E17K variant binds PIP2, moving from the cytosol to the plasma membrane with altered lipid affinity.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	320	R-HSA-2243937	PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1	yes	reactome/R-HSA-2243937.md	PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PIP2-bound AKT1 E17K associates with PDPK1 at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	321	R-HSA-2243938	AKT1 E17K mutant is phosphorylated by TORC2 complex	yes	reactome/R-HSA-2243938.md	AKT1 E17K mutant is phosphorylated by TORC2 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The event models Ser473 phosphorylation of membrane-bound AKT1 E17K by mTORC2; the kinase assignment is stated as presumptive.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	322	R-HSA-2243942	PDPK1 phosphorylates AKT1 E17K mutant	yes	reactome/R-HSA-2243942.md	PDPK1 phosphorylates AKT1 E17K mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The event models PDPK1 phosphorylation of membrane-bound AKT1 E17K and release of active AKT1 E17K into the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	323	R-HSA-199298	AKT phosphorylates CREB1	yes	reactome/R-HSA-199298.md	AKT phosphorylates CREB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates CREB1 at Ser133 in the nucleoplasm, linking PI3K signaling to CREB-dependent transcription.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	324	R-HSA-199299	AKT phosphorylates FOXO transcription factors	yes	reactome/R-HSA-199299.md	AKT phosphorylates FOXO transcription factors	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear AKT phosphorylates FOXO1, FOXO3 and FOXO4 at defined serine/threonine sites; the event explicitly distinguishes the less certain FOXO6 inference.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	325	R-HSA-199839	AKT can phosphorylate RSK	yes	reactome/R-HSA-199839.md	AKT can phosphorylate RSK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event models AKT phosphorylation of RPS6KB2 in the nucleoplasm; this is the nuclear S6 kinase substrate, not a transfer of its activity to AKT.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	326	R-HSA-199863	AKT can phosphorylate NR4A1 (NUR77)	yes	reactome/R-HSA-199863.md	AKT can phosphorylate NR4A1 (NUR77)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The event models nuclear AKT phosphorylation of NR4A1 but explicitly notes subsequent work favoring RSK/MSK as the physiological NR4A1 kinase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	327	R-HSA-211164	AKT phosphorylates FOXO1A	yes	reactome/R-HSA-211164.md	AKT phosphorylates FOXO1A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT catalyzes FOXO1 phosphorylation at Thr24, Ser256 and Ser319 in the nucleoplasm.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	328	R-HSA-3769394	AKT phosphorylates CBY1	yes	reactome/R-HSA-3769394.md	AKT phosphorylates CBY1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT1/AKT2 phosphorylates CBY1 at Ser20 in a nuclear beta-catenin complex, enabling subsequent 14-3-3-dependent export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	329	R-HSA-6805640	AKT phosphorylates KAT6A	yes	reactome/R-HSA-6805640.md	AKT phosphorylates KAT6A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates nuclear KAT6A at Thr369, preventing association with PML and reducing KAT6A-mediated TP53 acetylation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	330	R-HSA-6805785	AKT phosphorylates PHF20	yes	reactome/R-HSA-6805785.md	AKT phosphorylates PHF20	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates PHF20 at Ser291 in the nucleoplasm, regulating damage-induced TP53 stabilization.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	331	R-HSA-9624526	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR	yes	reactome/R-HSA-9624526.md	AKT phosphorylates FOXO3 downstream of ESR1 and EGFR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates FOXO3 in the nucleoplasm downstream of estrogen/EGFR signaling, promoting FOXO3 nuclear export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	332	R-HSA-9699579	AKT phosphorylates FOXO3 downstream of FLT3	yes	reactome/R-HSA-9699579.md	AKT phosphorylates FOXO3 downstream of FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates FOXO3 in the nucleoplasm downstream of FLT3 signaling, promoting FOXO3 nuclear export.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	333	R-NUL-8939977	Activated AKT1 phosphorylates Runx2	yes	reactome/R-NUL-8939977.md	Activated AKT1 phosphorylates Runx2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	This mixed-species reaction uses recombinant human AKT1 to phosphorylate mouse Runx2-5 at Ser203, Thr205 and Thr207; the model places the catalyst in nucleoplasm.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	334	R-HSA-1358791	Phosphorylation of USP8 by P-AKT	yes	reactome/R-HSA-1358791.md	Phosphorylation of USP8 by P-AKT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates USP8 at Thr945 in the cytosol, stabilizing the USP8–NRDP1 regulatory pathway.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	335	R-HSA-1497784	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle	yes	reactome/R-HSA-1497784.md	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	The BH4-binding event contains AKT1 in a NOS3–CaM–HSP90 complex explicitly assigned to the plasma membrane; BH4 is a cytosolic input.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	336	R-HSA-1497796	BH2 binding can lead to eNOS uncoupling	yes	reactome/R-HSA-1497796.md	BH2 binding can lead to eNOS uncoupling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	The BH2-exchange event places the AKT1-containing NOS3 complex at the plasma membrane, while the exchanged small molecules are cytosolic.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	337	R-HSA-1497810	Uncoupled eNOS favours the formation of superoxide	yes	reactome/R-HSA-1497810.md	Uncoupled eNOS favours the formation of superoxide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	Uncoupled NOS3 produces superoxide in a reaction whose AKT1-containing enzyme complex is at the plasma membrane; AKT1 is not the oxidoreductase.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	338	R-HSA-198270	PDPK1 phosphorylates AKT at T308	yes	reactome/R-HSA-198270.md	PDPK1 phosphorylates AKT at T308	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PDPK1 phosphorylates membrane-bound AKT at Thr308 and releases phosphorylated AKT into the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	339	R-HSA-198599	AKT phosphorylates MDM2	yes	reactome/R-HSA-198599.md	AKT phosphorylates MDM2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates MDM2 at Ser166 and Ser188 in the cytosol, regulating MDM2 stability and subsequent signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	340	R-HSA-198609	AKT phosphorylates TSC2, inhibiting it	yes	reactome/R-HSA-198609.md	AKT phosphorylates TSC2, inhibiting it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates TSC2 at Ser939 and Thr1462 in the cytosol, inhibiting the TSC regulatory branch upstream of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	341	R-HSA-198611	AKT phosphorylates IKKalpha	yes	reactome/R-HSA-198611.md	AKT phosphorylates IKKalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates the IKK subunit CHUK at Thr23 in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	342	R-HSA-198613	AKT phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-198613.md	AKT phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates the cell-cycle inhibitors CDKN1A and CDKN1B in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	343	R-HSA-198621	AKT phosphorylates caspase-9	yes	reactome/R-HSA-198621.md	AKT phosphorylates caspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates caspase-9 at Ser196 in the cytosol, inhibiting this apoptotic protease.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	344	R-HSA-199425	PHLPP dephosphorylates S473 in AKT	yes	reactome/R-HSA-199425.md	PHLPP dephosphorylates S473 in AKT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PHLPP dephosphorylates activated AKT in the cytosol; the localization assertion concerns the AKT substrate.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	345	R-HSA-200143	AKT phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-200143.md	AKT phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates AKT1S1/PRAS40 in the cytosol, relieving its inhibition of mTORC1.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	346	R-HSA-202111	AKT1 phosphorylates eNOS	yes	reactome/R-HSA-202111.md	AKT1 phosphorylates eNOS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	AKT1 phosphorylates NOS3 Ser1177 within a NOS3–CaM–HSP90–AKT1 complex assigned to the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	347	R-HSA-202127	eNOS synthesizes NO	yes	reactome/R-HSA-202127.md	eNOS synthesizes NO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	NOS3 synthesizes nitric oxide in an AKT1-containing complex assigned to the plasma membrane; the cytosolic species are reaction metabolites.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	348	R-HSA-202137	AKT1 binds eNOS complex via HSP90	yes	reactome/R-HSA-202137.md	AKT1 binds eNOS complex via HSP90	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AKT1 is recruited through HSP90 into a NOS3 complex at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	349	R-HSA-389756	AKT interacts and phosphorylates Cot	yes	reactome/R-HSA-389756.md	AKT interacts and phosphorylates Cot	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT interacts with MAP3K8/Cot and phosphorylates Ser400 in cytosolic assays; Reactome explicitly limits the evidence to in-vitro and overexpression conditions.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	350	R-HSA-390329	Dephosphorylation of AKT by PP2A	yes	reactome/R-HSA-390329.md	Dephosphorylation of AKT by PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PP2A dephosphorylates the AKT substrate in the cytosol during CTLA4-mediated inhibition of T-cell signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	351	R-HSA-450490	Protein Kinase B/Akt phosphorylates BRF1	yes	reactome/R-HSA-450490.md	Protein Kinase B/Akt phosphorylates BRF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates ZFP36L1/BRF1 at Ser92 and Ser203 in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	352	R-HSA-450499	Protein Kinase B (AKT) phosphorylates KSRP	yes	reactome/R-HSA-450499.md	Protein Kinase B (AKT) phosphorylates KSRP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates KHSRP at Ser193 in the cytosol, regulating the mRNA-decay factor rather than hydrolyzing RNA itself.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	353	R-HSA-6811504	AKT1 dephosphorylation by PP2A-B56-beta,gamma	yes	reactome/R-HSA-6811504.md	AKT1 dephosphorylation by PP2A-B56-beta,gamma	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PP2A complexes containing B56 beta or gamma dephosphorylate cytosolic AKT1 at Thr308 and Ser473.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	354	R-HSA-8933446	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling	yes	reactome/R-HSA-8933446.md	Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates DENND1A/DENND1B in the cytosol, relieving their autoinhibition and promoting RAB35 activation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	355	R-HSA-8948757	AKT phosphorylates MKRN1	yes	reactome/R-HSA-8948757.md	AKT phosphorylates MKRN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT1 phosphorylates cytosolic MKRN1 at Ser109, stabilizing this ubiquitin ligase in an EGF-responsive regulatory circuit.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	356	R-HSA-9604328	AKT1 phosphorylates NOTCH4	yes	reactome/R-HSA-9604328.md	AKT1 phosphorylates NOTCH4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Recombinant human AKT1 phosphorylates human NOTCH4 intracellular domain at four serines; the model places this inhibitory Notch-regulatory step in the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	357	R-NUL-3139045	AKT phosphorylates Bad	yes	reactome/R-NUL-3139045.md	AKT phosphorylates Bad	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This mixed-species reaction uses recombinant human AKT to phosphorylate recombinant mouse Bad at Ser136; the catalyst is human and the modeled location is cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	358	R-HSA-202111	AKT1 phosphorylates eNOS	yes	reactome/R-HSA-202111.md	AKT1 phosphorylates eNOS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	AKT1 phosphorylates NOS3 Ser1177 within a NOS3–CaM–HSP90–AKT1 complex assigned to the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	359	R-HSA-202137	AKT1 binds eNOS complex via HSP90	yes	reactome/R-HSA-202137.md	AKT1 binds eNOS complex via HSP90	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Cytosolic AKT1 is recruited through HSP90 into a NOS3 complex at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	360	R-HSA-377186	Activated AKT phosphorylates AKT1S1 (PRAS40)	yes	reactome/R-HSA-377186.md	Activated Akt1 phosphorylates AKT1S1 (PRAS40)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MODIFY	AKT phosphorylates AKT1S1/PRAS40 at Thr246; the current model explicitly places the AKT catalyst in the cytosol and the mTORC1 substrate complex at the lysosomal membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	361	R-HSA-432110	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding	yes	reactome/R-HSA-432110.md	Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	AKT1 can phosphorylate the integrin beta3 cytoplasmic tail at Thr779; the modeled kinase entity is at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	362	R-HSA-9860759	p-T816-PKN2 phosphorylates AKT1 on serine-308	yes	reactome/R-HSA-9860759.md	p-T816-PKN2 phosphorylates AKT1 on serine-308	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The event places activated AKT1 at the plasma membrane in endothelial cells under laminar flow, contrasting it with perinuclear localization under disturbed flow.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	363	R-HSA-9860792	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177	yes	reactome/R-HSA-9860792.md	Phospho-AKT1 phosphorylates NOS3 (eNOS) on serine-1177	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	AKT1 phosphorylates NOS3 Ser1177 at the plasma membrane during endothelial flow signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	364	R-HSA-198270	PDPK1 phosphorylates AKT at T308	yes	reactome/R-HSA-198270.md	PDPK1 phosphorylates AKT at T308	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PDPK1 phosphorylates membrane-bound AKT at Thr308 and releases phosphorylated AKT into the cytosol.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	365	R-HSA-198640	mTORC2 phosphorylates AKT at S473	yes	reactome/R-HSA-198640.md	TORC2 (mTOR) phosphorylates AKT at S473	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	mTORC2 phosphorylates PIP3-bound AKT at the plasma membrane; AKT is the substrate in this activation event.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	366	R-HSA-2317314	AKT binds PDPK1	yes	reactome/R-HSA-2317314.md	AKT binds PDPK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PIP3-bound, Ser473-phosphorylated AKT associates with PIP3-bound PDPK1 at the plasma membrane.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	367	R-HSA-9860800	mTORC2 phosphorylates AKT1 on serine-473	yes	reactome/R-HSA-9860800.md	mTORC2 phosphorylates AKT1 on serine-473	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	mTORC2 phosphorylates PIP3-bound AKT1 at the plasma membrane during endothelial flow signaling.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	372	R-HSA-2317332	PIP3 recruits AKT to the membrane	yes	reactome/R-HSA-2317332.md	PIP3 recruits AKT to the membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PIP3 recruits cytosolic AKT to the plasma membrane through its PH domain.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	373	R-HSA-2400010	AKT inhibitors block AKT membrane recruitment	yes	reactome/R-HSA-2400010.md	AKT inhibitors block AKT membrane recruitment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT inhibitors form cytosolic complexes with AKT and prevent its membrane recruitment; this is inhibitor binding to AKT, not inhibitor activity of AKT.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	374	R-HSA-6790041	Expression of STAT3-upregulated cytosolic proteins	yes	reactome/R-HSA-6790041.md	Expression of STAT3-upregulated cytosolic proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT1 is among the cytosolic protein products whose expression is upregulated by STAT3; the annotation concerns the location of that product.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	375	R-HSA-8848751	PTK6 binds AKT1	yes	reactome/R-HSA-8848751.md	PTK6 binds AKT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AKT1 binds the SH3 domain of PTK6 through its C-terminal proline-rich region.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	376	R-HSA-9603279	PIP3 recruits PDK1 and AKT to the membrane	yes	reactome/R-HSA-9603279.md	PIP3 recruits PDK1 and AKT to the membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PIP3 recruits both AKT and PDPK1 from cytosol to a plasma-membrane signaling complex.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	377	R-HSA-199443	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation	yes	reactome/R-HSA-199443.md	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	THEM4 or TRIB3 binds membrane-recruited AKT and inhibits its activating phosphorylation.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	378	R-HSA-2317332	PIP3 recruits AKT to the membrane	yes	reactome/R-HSA-2317332.md	PIP3 recruits AKT to the membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PIP3 recruits cytosolic AKT to the plasma membrane through its PH domain.
human	AKT1	genes/human/AKT1/AKT1-ai-review.yaml	AKT1	P31749	NCBITaxon:9606	Homo sapiens	379	R-HSA-9603279	PIP3 recruits PDK1 and AKT to the membrane	yes	reactome/R-HSA-9603279.md	PIP3 recruits PDK1 and AKT to the membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PIP3 recruits both AKT and PDPK1 from cytosol to a plasma-membrane signaling complex.
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	43	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Traceable (Reactome) involvement in heme biosynthesis; ALAD catalyzes the cytosolic condensation of two ALA into porphobilinogen within the eight-enzyme heme pathway.
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	48	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing ALAD in the extracellular region via neutrophil secretory-granule exocytosis.
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	49	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing ALAD in the extracellular region via ficolin-1-rich granule exocytosis.
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	50	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation to the secretory granule lumen (neutrophil degranulation).
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	51	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation to the ficolin-1-rich granule lumen (neutrophil degranulation).
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	56	R-HSA-189439	ALAD condenses 2 dALAs to form PBG	yes	reactome/R-HSA-189439.md	ALAD condenses 2 dALAs to form PBG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the ALAD-catalyzed ALA-condensation reaction in the cytosol.
human	ALAD	genes/human/ALAD/ALAD-ai-review.yaml	ALAD	P13716	NCBITaxon:9606	Homo sapiens	57	R-HSA-190141	ALAD binds to Pb2+	yes	reactome/R-HSA-190141.md	ALAD binds to Pb2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation of cytosolic localization (ALAD-Pb2+ binding reaction).
human	ALAS2	genes/human/ALAS2/ALAS2-ai-review.yaml	ALAS2	P22557	NCBITaxon:9606	Homo sapiens	27	R-HSA-189442	ALAS condenses SUCC-CoA and Gly to form dALA	yes	reactome/R-HSA-189442.md	ALAS condenses SUCC-CoA and Gly to form dALA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the ALAS condensation reaction in the mitochondrial matrix.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	15	R-HSA-2168887	Ferriheme is transferred from Albumin to Hemopexin	yes	reactome/R-HSA-2168887.md	Ferriheme is transferred from Albumin to Hemopexin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Heme transfer from albumin to hemopexin occurs extracellularly.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	16	R-HSA-264679	Serum albumin binds 2-lysophosphatidylcholine	yes	reactome/R-HSA-264679.md	Serum albumin binds 2-lysophosphatidylcholine	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin binds lysophosphatidylcholine in the extracellular compartment.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	17	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Platelet granule exocytosis releases albumin into extracellular fluid.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	18	R-HSA-9661419	ALB binds extracellular heme	yes	reactome/R-HSA-9661419.md	ALB binds extracellular heme	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin captures extracellular heme.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	19	R-HSA-9661425	BIL:ALB dissociates	yes	reactome/R-HSA-9661425.md	BIL:ALB dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Bilirubin is released from extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	20	R-HSA-9661432	BIL binds ALB	yes	reactome/R-HSA-9661432.md	BIL binds ALB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular albumin binds bilirubin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	21	R-HSA-9709883	BIL:ALB scavenges O2.-	yes	reactome/R-HSA-9709883.md	BIL:ALB scavenges O2.-	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin-bound bilirubin participates in extracellular oxidant scavenging.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	22	R-HSA-9733545	Bile salts and acids bind ALB	yes	reactome/R-HSA-9733545.md	Bile salts and acids bind ALB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin binds circulating bile salts and acids.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	23	R-HSA-9733960	Bile salts and acids dissociate from ALB	yes	reactome/R-HSA-9733960.md	Bile salts and acids dissociate from ALB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Bile salts and acids dissociate from extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	24	R-HSA-9749590	ASA- acetylates ALB	yes	reactome/R-HSA-9749590.md	ASA- acetylates ALB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Aspirin acetylates extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	25	R-HSA-9750666	ALB binds ST	yes	reactome/R-HSA-9750666.md	ALB binds ST	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Salicylate binds extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	26	R-HSA-9757574	ALB binds PREDL	yes	reactome/R-HSA-9757574.md	ALB binds PREDL	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin binds prednisolone in plasma.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	27	R-HSA-9757578	ALB binds PREDN	yes	reactome/R-HSA-9757578.md	ALB binds PREDN	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin binds prednisone in plasma.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	28	R-HSA-9762343	PREDL:ALB dissociates	yes	reactome/R-HSA-9762343.md	PREDL:ALB dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Prednisolone dissociates from extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	29	R-HSA-9762345	PREDN:ALB dissociates	yes	reactome/R-HSA-9762345.md	PREDN:ALB dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Prednisone dissociates from extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	30	R-HSA-9794444	ALB binds Cipro	yes	reactome/R-HSA-9794444.md	ALB binds Cipro	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Albumin binds ciprofloxacin extracellularly.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	31	R-HSA-9794475	Cipro:ALB dissociates	yes	reactome/R-HSA-9794475.md	Cipro:ALB dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Ciprofloxacin is released from extracellular albumin.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	34	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Albumin passes through the secretory lumen as a FAM20C substrate.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	35	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		REMOVE	Extracellular acceptance of completed heme is not a heme-synthetic step.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	44	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Albumin is cargo in platelet alpha-granule lumen.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	47	R-HSA-9707564	Cytoprotection by HMOX1	yes	reactome/R-HSA-9707564.md	Cytoprotection by HMOX1	Homo sapiens	GO:0034599	cellular response to oxidative stress	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Albumin participates in extracellular protection associated with the HMOX1 pathway.
human	ALB	genes/human/ALB/ALB-ai-review.yaml	ALB	P02768	NCBITaxon:9606	Homo sapiens	48	R-HSA-189483	Heme degradation	yes	reactome/R-HSA-189483.md	Heme degradation	Homo sapiens	GO:0042167	heme catabolic process	TAS	involved_in	BP	false		MODIFY	The specified albumin step carries bilirubin after heme breakdown.
human	ALDH18A1	genes/human/ALDH18A1/ALDH18A1-ai-review.yaml	ALDH18A1	P54886	NCBITaxon:9606	Homo sapiens	21	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		UNDECIDED	Reactome places the P5CS substrate entity in the mitochondrial inner membrane during LONP1 binding.
human	ALDH18A1	genes/human/ALDH18A1/ALDH18A1-ai-review.yaml	ALDH18A1	P54886	NCBITaxon:9606	Homo sapiens	22	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		UNDECIDED	Reactome places P5CS in the mitochondrial inner membrane during LONP1-mediated degradation.
human	ALDH18A1	genes/human/ALDH18A1/ALDH18A1-ai-review.yaml	ALDH18A1	P54886	NCBITaxon:9606	Homo sapiens	32	R-HSA-508040	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]	yes	reactome/R-HSA-508040.md	glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		UNDECIDED	The P5CS catalytic Reactome event explicitly describes inner-membrane association.
human	ALDH4A1	genes/human/ALDH4A1/ALDH4A1-ai-review.yaml	ALDH4A1	P30038	NCBITaxon:9606	Homo sapiens	12	R-HSA-6784402	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate	yes	reactome/R-HSA-6784402.md	ALDH4A1 converts 1PYR-3OH-5COOH to 4-OH-L-glutamate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome assigns matrix ALDH4A1 to a hydroxyproline-catabolic reaction.
human	ALDH4A1	genes/human/ALDH4A1/ALDH4A1-ai-review.yaml	ALDH4A1	P30038	NCBITaxon:9606	Homo sapiens	13	R-HSA-70679	ALDH4A1 oxidises L-GluSS to Glu	yes	reactome/R-HSA-70679.md	ALDH4A1 oxidises L-GluSS to Glu	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome assigns matrix ALDH4A1 to a proline-catabolic reaction.
human	ALDH4A1	genes/human/ALDH4A1/ALDH4A1-ai-review.yaml	ALDH4A1	P30038	NCBITaxon:9606	Homo sapiens	14	R-HSA-9929439	ALDH4A1 oxidizes 1PYR-3OH-5COOH	yes	reactome/R-HSA-9929439.md	ALDH4A1 oxidizes 1PYR-3OH-5COOH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome assigns matrix ALDH4A1 to a hydroxyproline-catabolic reaction.
human	ALDH5A1	genes/human/ALDH5A1/ALDH5A1-ai-review.yaml	ALDH5A1	P51649	NCBITaxon:9606	Homo sapiens	18	R-HSA-888548	ALDH5A1 dehydrogenates SUCCSA to SUCCA	yes	reactome/R-HSA-888548.md	ALDH5A1 dehydrogenates SUCCSA to SUCCA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The matrix-localized Reactome reaction agrees with the primary SSADH literature.
human	ALDH6A1	genes/human/ALDH6A1/ALDH6A1-ai-review.yaml	ALDH6A1	Q02252	NCBITaxon:9606	Homo sapiens	8	R-HSA-70895	Branched-chain amino acid catabolism	yes	reactome/R-HSA-70895.md	Branched-chain amino acid catabolism	Homo sapiens	GO:0009083	branched-chain amino acid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Valine catabolism is a branch of branched-chain amino acid catabolism, so this broader parent process is correct. It is less specific than the L-valine catabolic process annotation but is a valid, author-asserted Reactome pathway membership. Kept as a valid non-core generalization.
human	ALDH6A1	genes/human/ALDH6A1/ALDH6A1-ai-review.yaml	ALDH6A1	Q02252	NCBITaxon:9606	Homo sapiens	9	R-HSA-70893	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+	yes	reactome/R-HSA-70893.md	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+	Homo sapiens	GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	TAS	enables	MF	false		ACCEPT	Core catalytic activity, author-asserted by Reactome for the reaction methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+. Consistent with the experimental IMP annotation.
human	ALDH6A1	genes/human/ALDH6A1/ALDH6A1-ai-review.yaml	ALDH6A1	Q02252	NCBITaxon:9606	Homo sapiens	17	R-HSA-70893	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+	yes	reactome/R-HSA-70893.md	methylmalonate semialdehyde + NAD+ + CoA + H2O => propionyl-CoA + HCO3- + NADH + H+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Most specific and correct localization. As a matrix-soluble enzyme cleaved of its transit peptide, MMSDH acts in the mitochondrial matrix. Core cellular component; preferred over the plainer mitochondrion annotations.
human	ALDH7A1	genes/human/ALDH7A1/ALDH7A1-ai-review.yaml	ALDH7A1	P49419	NCBITaxon:9606	Homo sapiens	13	R-HSA-6798163	Choline catabolism	yes	reactome/R-HSA-6798163.md	Choline catabolism	Homo sapiens	GO:0042426	choline catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Betaine-aldehyde oxidation is a catalytic step in choline catabolism.
human	ALDH7A1	genes/human/ALDH7A1/ALDH7A1-ai-review.yaml	ALDH7A1	P49419	NCBITaxon:9606	Homo sapiens	14	R-HSA-6797955	ALDH7A1 oxidises BETALD to BET	yes	reactome/R-HSA-6797955.md	ALDH7A1 oxidises BETALD to BET	Homo sapiens	GO:0008802	betaine-aldehyde dehydrogenase (NAD+) activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome records the supported betaine-aldehyde reaction.
human	ALDH7A1	genes/human/ALDH7A1/ALDH7A1-ai-review.yaml	ALDH7A1	P49419	NCBITaxon:9606	Homo sapiens	38	R-HSA-6797955	ALDH7A1 oxidises BETALD to BET	yes	reactome/R-HSA-6797955.md	ALDH7A1 oxidises BETALD to BET	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the mitochondrial enzyme in the matrix.
human	ALDH7A1	genes/human/ALDH7A1/ALDH7A1-ai-review.yaml	ALDH7A1	P49419	NCBITaxon:9606	Homo sapiens	39	R-HSA-70941	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+	yes	reactome/R-HSA-70941.md	alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The lysine-catabolic Reactome catalyst is a matrix ALDH7A1 tetramer.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	20	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion that aldolase A participates in gluconeogenesis, where it catalyzes the reverse aldol condensation of DHAP + G3P into fructose-1,6-bisphosphate.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	21	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion for the canonical (glucose-derived) glycolytic pathway, the specific glycolysis subtype for aldolase A.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to secretory granule lumen via the neutrophil-degranulation exocytosis pathway, where abundant cytosolic proteins such as aldolase A are cargo of granule/secretion events.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	31	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to tertiary granule lumen via the neutrophil-degranulation pathway; aldolase A appears as granule cargo.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	32	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to ficolin-1-rich granule lumen via neutrophil degranulation; aldolase A is granule cargo.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	42	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to extracellular region via platelet alpha-granule exocytosis; abundant cytosolic aldolase A appears as granule/secretion cargo.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	43	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome extracellular-region localization via neutrophil-degranulation exocytosis.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	44	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome extracellular-region localization via neutrophil-degranulation exocytosis.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	45	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome extracellular-region localization via neutrophil-degranulation exocytosis.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	46	R-HSA-71495	Aldolase tetramers convert GA3P and DHAP to F1,6PP	yes	reactome/R-HSA-71495.md	Aldolase tetramers convert GA3P and DHAP to F1,6PP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the aldolase reaction (DHAP + G3P -> F1,6BP, gluconeogenic direction). Correct core localization.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	47	R-HSA-71496	Aldolase tetramer cleaves F1,6PP	yes	reactome/R-HSA-71496.md	Aldolase tetramer cleaves F1,6PP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the aldolase reaction (F1,6BP cleavage, glycolytic direction). Correct core localization.
human	ALDOA	genes/human/ALDOA/ALDOA-ai-review.yaml	ALDOA	P04075	NCBITaxon:9606	Homo sapiens	48	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to platelet alpha-granule lumen via the platelet-degranulation pathway; aldolase A appears as granule cargo.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	17	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	ALDOB performs the reversible aldol-condensation step of gluconeogenesis.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	18	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	ALDOB directly contributes to canonical glycolysis.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	35	R-HSA-5656438	Defective ALDOB does not cleave Fru 1-P to GA and DHAP	yes	reactome/R-HSA-5656438.md	Defective ALDOB does not cleave Fru 1-P to GA and DHAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The disease event retains ALDOB in the cytosolic compartment.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	38	R-HSA-70342	ALDOB tetramer cleaves Fru-1-P to GA and DHAP	yes	reactome/R-HSA-70342.md	ALDOB tetramer cleaves Fru-1-P to GA and DHAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The live F1P-cleavage event explicitly places ALDOB in cytosol.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	39	R-HSA-71495	Aldolase tetramers convert GA3P and DHAP to F1,6PP	yes	reactome/R-HSA-71495.md	Aldolase tetramers convert GA3P and DHAP to F1,6PP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The reverse aldol-condensation event is cytosolic.
human	ALDOB	genes/human/ALDOB/ALDOB-ai-review.yaml	ALDOB	P05062	NCBITaxon:9606	Homo sapiens	40	R-HSA-71496	Aldolase tetramer cleaves F1,6PP	yes	reactome/R-HSA-71496.md	Aldolase tetramer cleaves F1,6PP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The canonical aldol-cleavage event is cytosolic.
human	ALG1	genes/human/ALG1/ALG1-ai-review.yaml	ALG1	Q9BT22	NCBITaxon:9606	Homo sapiens	8	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	ALG1 catalyzes the first mannosylation step of dolichol-linked oligosaccharide synthesis.
human	ALG1	genes/human/ALG1/ALG1-ai-review.yaml	ALG1	Q9BT22	NCBITaxon:9606	Homo sapiens	9	R-HSA-446218	Addition of the first mannose to the N-glycan precursor by ALG1	yes	reactome/R-HSA-446218.md	Addition of the first mannose to the N-glycan precursor by ALG1	Homo sapiens	GO:0004578	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	The normal Reactome ALG1 reaction matches its specific catalytic function.
human	ALG1	genes/human/ALG1/ALG1-ai-review.yaml	ALG1	Q9BT22	NCBITaxon:9606	Homo sapiens	10	R-HSA-4549382	Defective ALG1 does not transfer the first Man to the N-glycan precursor	yes	reactome/R-HSA-4549382.md	Defective ALG1 does not transfer the first Man to the N-glycan precursor	Homo sapiens	GO:0004578	chitobiosyldiphosphodolichol beta-mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	The disease reaction describes loss of the established wild-type ALG1 activity.
human	ALG1	genes/human/ALG1/ALG1-ai-review.yaml	ALG1	Q9BT22	NCBITaxon:9606	Homo sapiens	17	R-HSA-4549382	Defective ALG1 does not transfer the first Man to the N-glycan precursor	yes	reactome/R-HSA-4549382.md	Defective ALG1 does not transfer the first Man to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease-associated ALG1 reaction is assigned to the normal ER membrane context.
human	ALG1	genes/human/ALG1/ALG1-ai-review.yaml	ALG1	Q9BT22	NCBITaxon:9606	Homo sapiens	18	R-HSA-446218	Addition of the first mannose to the N-glycan precursor by ALG1	yes	reactome/R-HSA-446218.md	Addition of the first mannose to the N-glycan precursor by ALG1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal ALG1 reaction takes place at the ER membrane.
human	ALG11	genes/human/ALG11/ALG11-ai-review.yaml	ALG11	Q2TAA5	NCBITaxon:9606	Homo sapiens	12	R-HSA-4551297	Defective ALG11 does not transfer Man to the N-glycan precursor	yes	reactome/R-HSA-4551297.md	Defective ALG11 does not transfer Man to the N-glycan precursor	Homo sapiens	GO:0000026	alpha-1,2-mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome author-statement annotation to the general alpha-1,2-mannosyltransferase activity, the parent of the specific ALG11 activity term.
human	ALG11	genes/human/ALG11/ALG11-ai-review.yaml	ALG11	Q2TAA5	NCBITaxon:9606	Homo sapiens	13	R-HSA-4551297	Defective ALG11 does not transfer Man to the N-glycan precursor	yes	reactome/R-HSA-4551297.md	Defective ALG11 does not transfer Man to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome author-statement localization of ALG11 to the ER membrane, where it acts on the cytosolic face during LLO assembly.
human	ALG12	genes/human/ALG12/ALG12-ai-review.yaml	ALG12	Q9BV10	NCBITaxon:9606	Homo sapiens	7	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	ALG12 catalyzes eighth-mannose addition in dolichol-linked oligosaccharide biosynthesis.
human	ALG12	genes/human/ALG12/ALG12-ai-review.yaml	ALG12	Q9BV10	NCBITaxon:9606	Homo sapiens	16	R-HSA-446198	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1	yes	reactome/R-HSA-446198.md	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1	Homo sapiens	GO:0000030	mannosyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome reaction resolves the donor and acceptor more precisely than generic mannosyltransferase activity.
human	ALG12	genes/human/ALG12/ALG12-ai-review.yaml	ALG12	Q9BV10	NCBITaxon:9606	Homo sapiens	17	R-HSA-4720497	Defective ALG12 does not add mannose to the N-glycan precursor	yes	reactome/R-HSA-4720497.md	Defective ALG12 does not add mannose to the N-glycan precursor	Homo sapiens	GO:0000030	mannosyltransferase activity	TAS	enables	MF	false		MODIFY	The disease event identifies the normal ALG12 reaction whose activity is impaired.
human	ALG12	genes/human/ALG12/ALG12-ai-review.yaml	ALG12	Q9BV10	NCBITaxon:9606	Homo sapiens	18	R-HSA-4720497	Defective ALG12 does not add mannose to the N-glycan precursor	yes	reactome/R-HSA-4720497.md	Defective ALG12 does not add mannose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease reaction places ALG12 in the ER membrane.
human	ALG12	genes/human/ALG12/ALG12-ai-review.yaml	ALG12	Q9BV10	NCBITaxon:9606	Homo sapiens	21	R-HSA-446198	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1	yes	reactome/R-HSA-446198.md	ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal ALG12 reaction is located in the ER membrane.
human	ALG13	genes/human/ALG13/ALG13-ai-review.yaml	ALG13	Q9NP73	NCBITaxon:9606	Homo sapiens	8	R-HSA-446207	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP	yes	reactome/R-HSA-446207.md	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome reaction places the ALG13–ALG14 enzyme at the ER membrane.
human	ALG13	genes/human/ALG13/ALG13-ai-review.yaml	ALG13	Q9NP73	NCBITaxon:9606	Homo sapiens	9	R-HSA-5633241	Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP	yes	reactome/R-HSA-5633241.md	Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The defective-ALG14 event retains the relevant ER-membrane enzyme context.
human	ALG14	genes/human/ALG14/ALG14-ai-review.yaml	ALG14	Q96F25	NCBITaxon:9606	Homo sapiens	13	R-HSA-5633241	Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP	yes	reactome/R-HSA-5633241.md	Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing ALG14 at the ER membrane (reaction: defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP). Consistent with all other localization evidence.
human	ALG14	genes/human/ALG14/ALG14-ai-review.yaml	ALG14	Q96F25	NCBITaxon:9606	Homo sapiens	14	R-HSA-446207	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP	yes	reactome/R-HSA-446207.md	ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing ALG14 at the ER membrane (reaction: ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP). Consistent with all other localization evidence.
human	ALG2	genes/human/ALG2/ALG2-ai-review.yaml	ALG2	Q9H553	NCBITaxon:9606	Homo sapiens	10	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in LLO (dolichol lipid-linked oligosaccharide) biosynthesis and transfer to nascent protein. Core biological process for ALG2.
human	ALG2	genes/human/ALG2/ALG2-ai-review.yaml	ALG2	Q9H553	NCBITaxon:9606	Homo sapiens	20	R-HSA-4549368	Defective ALG2 does not transfer a second Man to N-glycan precursor	yes	reactome/R-HSA-4549368.md	Defective ALG2 does not transfer a second Man to N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization. Consistent with the experimental localization of ALG2.
human	ALG2	genes/human/ALG2/ALG2-ai-review.yaml	ALG2	Q9H553	NCBITaxon:9606	Homo sapiens	22	R-HSA-446208	Addition of a second mannose to the N-glycan precursor by ALG2	yes	reactome/R-HSA-446208.md	Addition of a second mannose to the N-glycan precursor by ALG2	Homo sapiens	GO:0000033	alpha-1,3-mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted alpha-1,3-mannosyltransferase activity (addition of a second mannose to the N-glycan precursor by ALG2). Correct parent-level molecular function.
human	ALG2	genes/human/ALG2/ALG2-ai-review.yaml	ALG2	Q9H553	NCBITaxon:9606	Homo sapiens	23	R-HSA-4549368	Defective ALG2 does not transfer a second Man to N-glycan precursor	yes	reactome/R-HSA-4549368.md	Defective ALG2 does not transfer a second Man to N-glycan precursor	Homo sapiens	GO:0000033	alpha-1,3-mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted alpha-1,3-mannosyltransferase activity (from the defective-ALG2 / CDG-1i pathway). Correct parent-level molecular function.
human	ALG2	genes/human/ALG2/ALG2-ai-review.yaml	ALG2	Q9H553	NCBITaxon:9606	Homo sapiens	26	R-HSA-446208	Addition of a second mannose to the N-glycan precursor by ALG2	yes	reactome/R-HSA-446208.md	Addition of a second mannose to the N-glycan precursor by ALG2	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization. Consistent with the experimental localization of ALG2.
human	ALG3	genes/human/ALG3/ALG3-ai-review.yaml	ALG3	Q92685	NCBITaxon:9606	Homo sapiens	13	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	ALG3 adds the sixth mannose during dolichol-linked oligosaccharide assembly.
human	ALG3	genes/human/ALG3/ALG3-ai-review.yaml	ALG3	Q92685	NCBITaxon:9606	Homo sapiens	19	R-HSA-446188	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1	yes	reactome/R-HSA-446188.md	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1	Homo sapiens	GO:0000033	alpha-1,3-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	The normal Reactome event resolves the donor and acceptor beyond the broad linkage-specific MF.
human	ALG3	genes/human/ALG3/ALG3-ai-review.yaml	ALG3	Q92685	NCBITaxon:9606	Homo sapiens	20	R-HSA-4720473	Defective ALG3 does not add mannose to the N-glycan precursor	yes	reactome/R-HSA-4720473.md	Defective ALG3 does not add mannose to the N-glycan precursor	Homo sapiens	GO:0000033	alpha-1,3-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	The disease event identifies the normal ALG3 reaction that pathogenic variants impair.
human	ALG3	genes/human/ALG3/ALG3-ai-review.yaml	ALG3	Q92685	NCBITaxon:9606	Homo sapiens	21	R-HSA-4720473	Defective ALG3 does not add mannose to the N-glycan precursor	yes	reactome/R-HSA-4720473.md	Defective ALG3 does not add mannose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease reaction retains the ER-membrane compartment of ALG3.
human	ALG3	genes/human/ALG3/ALG3-ai-review.yaml	ALG3	Q92685	NCBITaxon:9606	Homo sapiens	22	R-HSA-446188	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1	yes	reactome/R-HSA-446188.md	ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome mannose-transfer reaction acts at the ER membrane.
human	ALG5	genes/human/ALG5/ALG5-ai-review.yaml	ALG5	Q9Y673	NCBITaxon:9606	Homo sapiens	10	R-HSA-480985	Synthesis of dolichyl-phosphate-glucose	yes	reactome/R-HSA-480985.md	Synthesis of dolichyl-phosphate-glucose	Homo sapiens	GO:0006487	protein N-linked glycosylation	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in protein N-linked glycosylation. ALG5 makes Dol-P-Glc, the glucose donor for the terminal LLO glucosylation steps that produce the fully assembled glycan precursor transferred to nascent proteins.
human	ALG5	genes/human/ALG5/ALG5-ai-review.yaml	ALG5	Q9Y673	NCBITaxon:9606	Homo sapiens	11	R-HSA-446214	Synthesis of dolichyl-phosphate-glucose	yes	reactome/R-HSA-446214.md	Synthesis of dolichyl-phosphate-glucose	Homo sapiens	GO:0004581	dolichyl-phosphate beta-glucosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted dolichyl-phosphate beta-glucosyltransferase activity. Reactome describes ALG5 catalyzing UDP-glucose + dolichyl phosphate to form Dol-P-Glc on the cytosolic face of the ER membrane.
human	ALG5	genes/human/ALG5/ALG5-ai-review.yaml	ALG5	Q9Y673	NCBITaxon:9606	Homo sapiens	19	R-HSA-446214	Synthesis of dolichyl-phosphate-glucose	yes	reactome/R-HSA-446214.md	Synthesis of dolichyl-phosphate-glucose	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization of ALG5, consistent with the experimental and phylogenetic ER-membrane annotations.
human	ALG6	genes/human/ALG6/ALG6-ai-review.yaml	ALG6	Q9Y672	NCBITaxon:9606	Homo sapiens	8	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome places ALG6-mediated first-glucose transfer within LLO biosynthesis.
human	ALG6	genes/human/ALG6/ALG6-ai-review.yaml	ALG6	Q9Y672	NCBITaxon:9606	Homo sapiens	16	R-HSA-446202	Addition of the first glucose to the N-glycan precursor by ALG6	yes	reactome/R-HSA-446202.md	Addition of the first glucose to the N-glycan precursor by ALG6	Homo sapiens	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS	enables	MF	false		MODIFY	The normal Reactome event explicitly models first-glucose transfer by ALG6.
human	ALG6	genes/human/ALG6/ALG6-ai-review.yaml	ALG6	Q9Y672	NCBITaxon:9606	Homo sapiens	17	R-HSA-4724291	Defective ALG6 does not add glucose to the N-glycan precursor	yes	reactome/R-HSA-4724291.md	Defective ALG6 does not add glucose to the N-glycan precursor	Homo sapiens	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS	enables	MF	false		MODIFY	The disease Reactome event describes altered ALG6 activity in the same first-glucose reaction.
human	ALG6	genes/human/ALG6/ALG6-ai-review.yaml	ALG6	Q9Y672	NCBITaxon:9606	Homo sapiens	18	R-HSA-4724291	Defective ALG6 does not add glucose to the N-glycan precursor	yes	reactome/R-HSA-4724291.md	Defective ALG6 does not add glucose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease-context Reactome catalyst is assigned to the ER membrane.
human	ALG6	genes/human/ALG6/ALG6-ai-review.yaml	ALG6	Q9Y672	NCBITaxon:9606	Homo sapiens	20	R-HSA-446202	Addition of the first glucose to the N-glycan precursor by ALG6	yes	reactome/R-HSA-446202.md	Addition of the first glucose to the N-glycan precursor by ALG6	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome first-glucose reaction places its ALG6 catalyst in the ER membrane.
human	ALG8	genes/human/ALG8/ALG8-ai-review.yaml	ALG8	Q9BVK2	NCBITaxon:9606	Homo sapiens	11	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	The Reactome pathway places ALG8 in lipid-linked precursor biosynthesis.
human	ALG8	genes/human/ALG8/ALG8-ai-review.yaml	ALG8	Q9BVK2	NCBITaxon:9606	Homo sapiens	19	R-HSA-446189	Addition of a second glucose to the N-glycan precursor by ALG8	yes	reactome/R-HSA-446189.md	Addition of a second glucose to the N-glycan precursor by ALG8	Homo sapiens	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS	enables	MF	false		MODIFY	The normal Reactome reaction resolves the acceptor-specific ALG8 activity.
human	ALG8	genes/human/ALG8/ALG8-ai-review.yaml	ALG8	Q9BVK2	NCBITaxon:9606	Homo sapiens	20	R-HSA-4724330	Defective ALG8 does not add glucose to the N-glycan precursor	yes	reactome/R-HSA-4724330.md	Defective ALG8 does not add glucose to the N-glycan precursor	Homo sapiens	GO:0004583	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS	enables	MF	false		MODIFY	The disease event describes failure of the normal ALG8 glucosyl-transfer step.
human	ALG8	genes/human/ALG8/ALG8-ai-review.yaml	ALG8	Q9BVK2	NCBITaxon:9606	Homo sapiens	22	R-HSA-4724330	Defective ALG8 does not add glucose to the N-glycan precursor	yes	reactome/R-HSA-4724330.md	Defective ALG8 does not add glucose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease-associated ALG8 entity is assigned to the ER membrane.
human	ALG8	genes/human/ALG8/ALG8-ai-review.yaml	ALG8	Q9BVK2	NCBITaxon:9606	Homo sapiens	23	R-HSA-446189	Addition of a second glucose to the N-glycan precursor by ALG8	yes	reactome/R-HSA-446189.md	Addition of a second glucose to the N-glycan precursor by ALG8	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal ALG8 reaction occurs at the ER membrane.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	8	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Retain ALG9 participation in dolichol-linked oligosaccharide biosynthesis.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	18	R-HSA-446215	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1	yes	reactome/R-HSA-446215.md	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1	Homo sapiens	GO:0000026	alpha-1,2-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine this event to the specific seventh-mannose transfer.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	19	R-HSA-446216	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1	yes	reactome/R-HSA-446216.md	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1	Homo sapiens	GO:0000026	alpha-1,2-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine this event to the specific ninth-mannose transfer.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	20	R-HSA-4720478	Defective ALG9 does not add the seventh mannose to the N-glycan precursor	yes	reactome/R-HSA-4720478.md	Defective ALG9 does not add the seventh mannose to the N-glycan precursor	Homo sapiens	GO:0000026	alpha-1,2-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine this event to the specific seventh-mannose transfer.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	21	R-HSA-9035514	Defective ALG9 does not add the last mannose to the N-glycan precursor	yes	reactome/R-HSA-9035514.md	Defective ALG9 does not add the last mannose to the N-glycan precursor	Homo sapiens	GO:0000026	alpha-1,2-mannosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine this event to the specific ninth-mannose transfer.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	22	R-HSA-4720478	Defective ALG9 does not add the seventh mannose to the N-glycan precursor	yes	reactome/R-HSA-4720478.md	Defective ALG9 does not add the seventh mannose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain the ER-membrane placement of ALG9.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	23	R-HSA-9035514	Defective ALG9 does not add the last mannose to the N-glycan precursor	yes	reactome/R-HSA-9035514.md	Defective ALG9 does not add the last mannose to the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain the ER-membrane placement of ALG9.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	25	R-HSA-446215	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1	yes	reactome/R-HSA-446215.md	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain the ER-membrane placement of ALG9.
human	ALG9	genes/human/ALG9/ALG9-ai-review.yaml	ALG9	Q9H6U8	NCBITaxon:9606	Homo sapiens	26	R-HSA-446216	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1	yes	reactome/R-HSA-446216.md	ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain the ER-membrane placement of ALG9.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	6	R-HSA-201521	ALK autophosphorylation	yes	reactome/R-HSA-201521.md	ALK autophosphorylation	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		MODIFY	Refine kinase chemistry to the established receptor tyrosine kinase activity.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	7	R-HSA-9700168	Active ALK phosphorylates IRS1	yes	reactome/R-HSA-9700168.md	Active ALK phosphorylates IRS1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	8	R-HSA-9700171	Active ALK phosphorylates PLCG1	yes	reactome/R-HSA-9700171.md	Active ALK phosphorylates PLCG1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	9	R-HSA-9700175	Active ALK phosphorylates SHC1	yes	reactome/R-HSA-9700175.md	Active ALK phosphorylates SHC1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	10	R-HSA-9700193	ALK mutants phosphorylate SHC1	yes	reactome/R-HSA-9700193.md	ALK mutants phosphorylate SHC1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	11	R-HSA-9701488	Active ALK phosphorylates JAK3	yes	reactome/R-HSA-9701488.md	Active ALK phosphorylates JAK3	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	12	R-NUL-9700161	p-7Y ALK dimer phosphorylates Frs2	yes	reactome/R-NUL-9700161.md	p-7Y ALK dimer phosphorylates Frs2	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	13	R-NUL-9700655	Active ALK phosphorylates Src	yes	reactome/R-NUL-9700655.md	Active ALK phosphorylates Src	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Retain the tyrosine kinase activity at the resolution of this reaction model.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	38	R-HSA-201486	ALK binds ligand pleiotrophin (PTN)	yes	reactome/R-HSA-201486.md	ALK binds ligand pleiotrophin (PTN)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	39	R-HSA-201510	PI3K synthesizes PIP3 downstream of ALK	yes	reactome/R-HSA-201510.md	PI3K synthesizes PIP3 downstream of ALK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	40	R-HSA-201515	Active ALK recruits PI3K	yes	reactome/R-HSA-201515.md	Active ALK recruits PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	41	R-HSA-201521	ALK autophosphorylation	yes	reactome/R-HSA-201521.md	ALK autophosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	42	R-HSA-9667914	ALK binds ligand midkine (MDK)	yes	reactome/R-HSA-9667914.md	ALK binds ligand midkine (MDK)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	43	R-HSA-9700114	NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684	yes	reactome/R-HSA-9700114.md	NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	44	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	45	R-HSA-9700149	Active ALK binds PLCG1	yes	reactome/R-HSA-9700149.md	Active ALK binds PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	46	R-HSA-9700154	Active ALK binds SHC1	yes	reactome/R-HSA-9700154.md	Active ALK binds SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	47	R-HSA-9700156	Active ALK dimer binds IRS1	yes	reactome/R-HSA-9700156.md	Active ALK dimer binds IRS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	48	R-HSA-9700168	Active ALK phosphorylates IRS1	yes	reactome/R-HSA-9700168.md	Active ALK phosphorylates IRS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	49	R-HSA-9700171	Active ALK phosphorylates PLCG1	yes	reactome/R-HSA-9700171.md	Active ALK phosphorylates PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	50	R-HSA-9700175	Active ALK phosphorylates SHC1	yes	reactome/R-HSA-9700175.md	Active ALK phosphorylates SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	51	R-HSA-9700184	Ligand-independent dimerization of point mutants of ALK	yes	reactome/R-HSA-9700184.md	Ligand-independent dimerization of point mutants of ALK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	52	R-HSA-9700186	Autophosphorylation of point mutants of ALK	yes	reactome/R-HSA-9700186.md	Autophosphorylation of point mutants of ALK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	53	R-HSA-9700190	ALK mutants bind SHC	yes	reactome/R-HSA-9700190.md	ALK mutants bind SHC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	54	R-HSA-9700193	ALK mutants phosphorylate SHC1	yes	reactome/R-HSA-9700193.md	ALK mutants phosphorylate SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	55	R-HSA-9700200	PTPRZ dephosphorylates ligand-bound ALK dimers	yes	reactome/R-HSA-9700200.md	PTPRZ dephosphorylates ligand-bound ALK dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	56	R-HSA-9700646	ASP-3026- resistant ALK mutants don't bind ASP-3026	yes	reactome/R-HSA-9700646.md	ASP-3026- resistant ALK mutants don't bind ASP-3026	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	57	R-HSA-9700656	alectinib resistant ALK mutants don't bind alectinib	yes	reactome/R-HSA-9700656.md	alectinib resistant ALK mutants don't bind alectinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	58	R-HSA-9700658	ceritinib-resistant ALK mutants don't bind ceritinib	yes	reactome/R-HSA-9700658.md	ceritinib-resistant ALK mutants don't bind ceritinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	59	R-HSA-9700662	Liganded-ALK dimer binds type I ALK-binding TKIs	yes	reactome/R-HSA-9700662.md	Liganded-ALK dimer binds type I ALK-binding TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	60	R-HSA-9701485	Active ALK binds JAK3	yes	reactome/R-HSA-9701485.md	Active ALK binds JAK3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	61	R-HSA-9701488	Active ALK phosphorylates JAK3	yes	reactome/R-HSA-9701488.md	Active ALK phosphorylates JAK3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	62	R-HSA-9701507	PTPN6 dephosphorylates JAK3	yes	reactome/R-HSA-9701507.md	PTPN6 dephosphorylates JAK3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	63	R-HSA-9701524	STAT3 is phosphorylated downstream of active ALK	yes	reactome/R-HSA-9701524.md	STAT3 is phosphorylated downstream of active ALK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	64	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	65	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	66	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	67	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	68	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	69	R-HSA-9715355	lorlatinib-resistant ALK mutants don't bind lorlatinib	yes	reactome/R-HSA-9715355.md	lorlatinib-resistant ALK mutants don't bind lorlatinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	70	R-HSA-9715356	brigatinib-resistant ALK mutants don't bind brigatinib	yes	reactome/R-HSA-9715356.md	brigatinib-resistant ALK mutants don't bind brigatinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	71	R-HSA-9715357	crizotinib-resistant ALK mutants don't bind crizotinib	yes	reactome/R-HSA-9715357.md	crizotinib-resistant ALK mutants don't bind crizotinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	72	R-HSA-9724099	ALK mutants:p-3Y SHC binds GRB2	yes	reactome/R-HSA-9724099.md	ALK mutants:p-3Y SHC binds GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	73	R-HSA-9725117	ALK gene expression	yes	reactome/R-HSA-9725117.md	ALK gene expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	74	R-HSA-9842656	ALK binds ALKAL ligand	yes	reactome/R-HSA-9842656.md	ALK binds ALKAL ligand	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	75	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	76	R-NUL-9700145	Active ALK binds Frs2	yes	reactome/R-NUL-9700145.md	Active ALK binds Frs2	Rattus norvegicus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	77	R-NUL-9700161	p-7Y ALK dimer phosphorylates Frs2	yes	reactome/R-NUL-9700161.md	p-7Y ALK dimer phosphorylates Frs2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	78	R-NUL-9700655	Active ALK phosphorylates Src	yes	reactome/R-NUL-9700655.md	Active ALK phosphorylates Src	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALK	genes/human/ALK/ALK-ai-review.yaml	ALK	Q9UM73	NCBITaxon:9606	Homo sapiens	79	R-NUL-9700661	Active ALK binds Src	yes	reactome/R-NUL-9700661.md	Active ALK binds Src	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the normal ALK plasma-membrane assertion at pathway-model resolution.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	15	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	16	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	17	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	18	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	19	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	20	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	21	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	22	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	23	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	24	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	25	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	26	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	27	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	28	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	29	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	30	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	31	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	32	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	33	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	34	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	35	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALMS1	genes/human/ALMS1/ALMS1-ai-review.yaml	ALMS1	Q8TCU4	NCBITaxon:9606	Homo sapiens	36	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosol location, supported by human-cell immunofluorescence.
human	ALPG	genes/human/ALPG/ALPG-ai-review.yaml	ALPG	P10696	NCBITaxon:9606	Homo sapiens	7	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	From the Reactome reaction in which GPLD1 cleaves GPI anchors, releasing anchored proteins from the membrane into extracellular fluid.
human	ALPG	genes/human/ALPG/ALPG-ai-review.yaml	ALPG	P10696	NCBITaxon:9606	Homo sapiens	8	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome's statement of the substrate side of the same reaction: ALPG is a GPI-anchored plasma membrane protein before GPLD1 acts on it.
human	ALPI	genes/human/ALPI/ALPI-ai-review.yaml	ALPI	P09923	NCBITaxon:9606	Homo sapiens	9	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	From the Reactome reaction in which GPLD1 cleaves GPI anchors, releasing anchored proteins from the membrane. For ALPI this is not merely a biochemical possibility but the physiological route to its main site of action: the enzyme is shed from the brush border into the gut lumen, and faecal ALPI activity is the assay used to demonstrate deficiency in patients.
human	ALPI	genes/human/ALPI/ALPI-ai-review.yaml	ALPI	P09923	NCBITaxon:9606	Homo sapiens	10	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome's statement of the substrate side of the GPI-cleavage reaction: ALPI is a GPI-anchored plasma membrane protein before GPLD1 acts on it.
human	ALPI	genes/human/ALPI/ALPI-ai-review.yaml	ALPI	P09923	NCBITaxon:9606	Homo sapiens	11	R-HSA-8878787	ALPI dimer hydrolyses phosphate monoesters	yes	reactome/R-HSA-8878787.md	ALPI dimer hydrolyses phosphate monoesters	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A second Reactome-derived plasma membrane assertion, from a different reaction in which ALPI participates as a membrane-resident phosphatase.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	7	R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	yes	reactome/R-HSA-9645460.md	Alpha-protein kinase 1 signaling pathway	Homo sapiens	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	ALPK1 initiates cytosolic bacterial nucleotide-heptose sensing through TIFA.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	20	R-HSA-9645394	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	yes	reactome/R-HSA-9645394.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	21	R-HSA-9645406	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)	yes	reactome/R-HSA-9645406.md	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	22	R-HSA-9645414	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	yes	reactome/R-HSA-9645414.md	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	23	R-HSA-9645428	ALPK1 binds ADP-heptose	yes	reactome/R-HSA-9645428.md	ALPK1 binds ADP-heptose	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	24	R-HSA-9645442	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex	yes	reactome/R-HSA-9645442.md	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	25	R-HSA-9645481	TIFA oligomerization	yes	reactome/R-HSA-9645481.md	TIFA oligomerization	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	26	R-HSA-9645501	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex	yes	reactome/R-HSA-9645501.md	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	27	R-HSA-9645520	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6	yes	reactome/R-HSA-9645520.md	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	28	R-HSA-9645524	ALPK1:ADP-heptose binds TIFA	yes	reactome/R-HSA-9645524.md	ALPK1:ADP-heptose binds TIFA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	29	R-HSA-9645535	ALPK1 phosphorylates TIFA	yes	reactome/R-HSA-9645535.md	ALPK1 phosphorylates TIFA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPK1	genes/human/ALPK1/ALPK1-ai-review.yaml	ALPK1	Q96QP1	NCBITaxon:9606	Homo sapiens	30	R-HSA-9758604	Ubiquitination of IKBKG by TRAF6	yes	reactome/R-HSA-9758604.md	Ubiquitination of IKBKG by TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated signaling event places ALPK1 in its cytosolic pathway context.
human	ALPL	genes/human/ALPL/ALPL-ai-review.yaml	ALPL	P05186	NCBITaxon:9606	Homo sapiens	65	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular TNAP includes an enzymatically active soluble pool.
human	ALPL	genes/human/ALPL/ALPL-ai-review.yaml	ALPL	P05186	NCBITaxon:9606	Homo sapiens	66	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome GPI-anchor substrate context is consistent with membrane-associated TNAP.
human	ALS2	genes/human/ALS2/ALS2-ai-review.yaml	ALS2	Q96Q42	NCBITaxon:9606	Homo sapiens	20	R-HSA-8875320	RAB5 GEFs exchange GTP for GDP on RAB5	yes	reactome/R-HSA-8875320.md	RAB5 GEFs exchange GTP for GDP on RAB5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the Rab5 exchange machinery on the cytosolic side.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	8	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway (synthesis of bile acids via 7alpha-hydroxycholesterol) places AMACR in bile-acid biosynthesis via racemization of the C27 intermediate.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	9	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway (synthesis of bile acids via 24-hydroxycholesterol) places AMACR in bile-acid biosynthesis. Duplicate of the biosynthetic-process annotation from a parallel Reactome route.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	10	R-HSA-389887	Beta-oxidation of pristanoyl-CoA	yes	reactome/R-HSA-389887.md	Beta-oxidation of pristanoyl-CoA	Homo sapiens	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	involved_in	BP	false		ACCEPT	Reactome pathway (beta-oxidation of pristanoyl-CoA) places AMACR in peroxisomal branched-chain fatty acid beta-oxidation. AMACR produces the (S)-pristanoyl-CoA that the acyl-CoA oxidase step can act on.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	14	R-HSA-192056	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA	yes	reactome/R-HSA-192056.md	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA	Homo sapiens	GO:0008111	alpha-methylacyl-CoA racemase activity	TAS	enables	MF	false		ACCEPT	Reactome (isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA) asserts the racemase activity on a specific bile-acid intermediate substrate.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	15	R-HSA-193452	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA	yes	reactome/R-HSA-193452.md	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA	Homo sapiens	GO:0008111	alpha-methylacyl-CoA racemase activity	TAS	enables	MF	false		ACCEPT	Reactome (isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA) asserts the racemase activity on the DHCA-CoA bile-acid intermediate.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	16	R-HSA-193736	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	yes	reactome/R-HSA-193736.md	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	Homo sapiens	GO:0008111	alpha-methylacyl-CoA racemase activity	TAS	enables	MF	false		ACCEPT	Reactome (isomerization of 3,7,24-THCA-CoA) asserts racemase activity on a bile-acid intermediate. Duplicate assertion of the core function.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	17	R-HSA-193763	TODO: Fetch title	no				GO:0008111	alpha-methylacyl-CoA racemase activity	TAS	enables	MF	false		ACCEPT	Reactome assertion of AMACR racemase activity within the bile-acid synthesis pathway. Duplicate assertion of the core function.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	19	R-HSA-192056	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA	yes	reactome/R-HSA-192056.md	Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome places AMACR in the peroxisomal matrix, the soluble compartment where matrix enzymes act after PTS1-mediated import.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	20	R-HSA-193452	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA	yes	reactome/R-HSA-193452.md	Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal-matrix localization (DHCA-CoA isomerization context). Duplicate of the peroxisomal-matrix location.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	21	R-HSA-193736	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	yes	reactome/R-HSA-193736.md	Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal-matrix localization (3,7,24-THCA-CoA context). Duplicate of the peroxisomal-matrix location.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	22	R-HSA-193763	TODO: Fetch title	no				GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal-matrix localization. Duplicate of the peroxisomal-matrix location.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	23	R-HSA-389897	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA	yes	reactome/R-HSA-389897.md	Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal-matrix localization (pristanoyl-CoA isomerization context). Duplicate of the peroxisomal-matrix location.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	24	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal-matrix localization (peroxisomal import context). Duplicate of the peroxisomal-matrix location.
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	31	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome ""cytosol"" localization arising from the peroxisomal protein-import reaction (cargo translocates from cytosol to peroxisomal matrix). This reflects a transient import intermediate, not a functional cytosolic pool."
human	AMACR	genes/human/AMACR/AMACR-ai-review.yaml	AMACR	Q9UHK6	NCBITaxon:9606	Homo sapiens	32	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome ""cytosol"" localization from the peroxisomal docking/translocation import step (PEX5:cargo binding the docking module). Transient import intermediate, not a functional cytosolic pool."
human	AMBRA1	genes/human/AMBRA1/AMBRA1-ai-review.yaml	AMBRA1	Q9C0C7	NCBITaxon:9606	Homo sapiens	81	R-HSA-1632843	AMBRA1 binds DYNLL1,DYNLL2	yes	reactome/R-HSA-1632843.md	AMBRA1 binds DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization is supported by Reactome and AMBRA1 autophagy/mitophagy evidence.
human	AMBRA1	genes/human/AMBRA1/AMBRA1-ai-review.yaml	AMBRA1	Q9C0C7	NCBITaxon:9606	Homo sapiens	82	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization is supported by Reactome and AMBRA1 autophagy/mitophagy evidence.
human	AMBRA1	genes/human/AMBRA1/AMBRA1-ai-review.yaml	AMBRA1	Q9C0C7	NCBITaxon:9606	Homo sapiens	83	R-HSA-5678313	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	yes	reactome/R-HSA-5678313.md	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization is supported by Reactome and AMBRA1 autophagy/mitophagy evidence.
human	AMBRA1	genes/human/AMBRA1/AMBRA1-ai-review.yaml	AMBRA1	Q9C0C7	NCBITaxon:9606	Homo sapiens	84	R-HSA-5678315	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	yes	reactome/R-HSA-5678315.md	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization is supported by Reactome and AMBRA1 autophagy/mitophagy evidence.
human	AMD1	genes/human/AMD1/AMD1-ai-review.yaml	AMD1	P17707	NCBITaxon:9606	Homo sapiens	12	R-HSA-351202	Metabolism of polyamines	yes	reactome/R-HSA-351202.md	Metabolism of polyamines	Homo sapiens	GO:0006595	polyamine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome traceable assignment placing AMD1 in polyamine metabolism, which is correct. This is a more general parent of the specific spermidine/spermine biosynthetic process annotations; kept as a valid but less specific process term.
human	AMD1	genes/human/AMD1/AMD1-ai-review.yaml	AMD1	P17707	NCBITaxon:9606	Homo sapiens	13	R-HSA-351222	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2	yes	reactome/R-HSA-351222.md	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2	Homo sapiens	GO:0004014	adenosylmethionine decarboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assignment of the core catalytic activity (the reaction S-adenosylmethionine <=> decarboxylated-adenosylmethionine + CO2). Correct core molecular function.
human	AMD1	genes/human/AMD1/AMD1-ai-review.yaml	AMD1	P17707	NCBITaxon:9606	Homo sapiens	19	R-HSA-351222	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2	yes	reactome/R-HSA-351222.md	S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization, consistent with AdoMetDC being a soluble cytosolic metabolic enzyme with no membrane/organelle targeting. Correct cellular component.
human	AMDHD1	genes/human/AMDHD1/AMDHD1-ai-review.yaml	AMDHD1	Q96NU7	NCBITaxon:9606	Homo sapiens	11	R-HSA-70921	Histidine catabolism	yes	reactome/R-HSA-70921.md	Histidine catabolism	Homo sapiens	GO:0006548	L-histidine catabolic process	TAS	involved_in	BP	false		ACCEPT	"Core biological process, author-asserted via Reactome's ""Histidine catabolism"" pathway, in which AMDHD1 catalyses step 3 (4-imidazolone-5-propanoate to N-formimino-L-glutamate). Correct."
human	AMDHD1	genes/human/AMDHD1/AMDHD1-ai-review.yaml	AMDHD1	Q96NU7	NCBITaxon:9606	Homo sapiens	12	R-HSA-70906	4-imidazolone-5-propanoate + H2O => N-formiminoglutamate	yes	reactome/R-HSA-70906.md	4-imidazolone-5-propanoate + H2O => N-formiminoglutamate	Homo sapiens	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	TAS	enables	MF	false		MODIFY	Correct reaction class from Reactome (the 4-imidazolone-5-propanoate + H2O reaction) but over-general relative to the specific catalytic term. Replace with GO:0050480 imidazolonepropionase activity.
human	AMDHD1	genes/human/AMDHD1/AMDHD1-ai-review.yaml	AMDHD1	Q96NU7	NCBITaxon:9606	Homo sapiens	13	R-HSA-70906	4-imidazolone-5-propanoate + H2O => N-formiminoglutamate	yes	reactome/R-HSA-70906.md	4-imidazolone-5-propanoate + H2O => N-formiminoglutamate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct and appropriately precise location. Reactome places the imidazolonepropionase reaction in the cytosol, consistent with the soluble histidine-catabolic enzymes and with UniProt's experimental cytoplasmic localization. This is the preferred location term (over the parent GO:0005737 cytoplasm).
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	23	R-HSA-195251	Assembly of the destruction complex	yes	reactome/R-HSA-195251.md	Assembly of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	24	R-HSA-195275	Phosphorylation of APC component of the destruction complex	yes	reactome/R-HSA-195275.md	Phosphorylation of APC component of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	25	R-HSA-195280	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	yes	reactome/R-HSA-195280.md	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	26	R-HSA-195283	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	yes	reactome/R-HSA-195283.md	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	27	R-HSA-195287	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	yes	reactome/R-HSA-195287.md	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	28	R-HSA-195300	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	yes	reactome/R-HSA-195300.md	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	29	R-HSA-195304	Association of beta-catenin with the destruction complex	yes	reactome/R-HSA-195304.md	Association of beta-catenin with the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	30	R-HSA-195318	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	yes	reactome/R-HSA-195318.md	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	31	R-HSA-201685	Beta-catenin is released from the destruction complex	yes	reactome/R-HSA-201685.md	Beta-catenin is released from the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	32	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	33	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	34	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	35	R-HSA-4791278	APC truncation mutants have impaired AXIN binding	yes	reactome/R-HSA-4791278.md	APC truncation mutants have impaired AXIN binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	36	R-HSA-4827388	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	yes	reactome/R-HSA-4827388.md	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	37	R-HSA-4839634	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839634.md	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	38	R-HSA-4839635	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839635.md	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	39	R-HSA-4839638	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839638.md	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	40	R-HSA-4839734	AXIN mutants destabilize the destruction complex	yes	reactome/R-HSA-4839734.md	AXIN mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	41	R-HSA-5229343	AXIN is phosphorylated in the destruction complex	yes	reactome/R-HSA-5229343.md	AXIN is phosphorylated in the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	42	R-HSA-5251557	Expression of AMER1 gene	yes	reactome/R-HSA-5251557.md	Expression of AMER1 gene	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMER1	genes/human/AMER1/AMER1-ai-review.yaml	AMER1	Q5JTC6	NCBITaxon:9606	Homo sapiens	43	R-HSA-5339713	Misspliced GSK3beta mutants stabilize beta-catenin levels	yes	reactome/R-HSA-5339713.md	Misspliced GSK3beta mutants stabilize beta-catenin levels	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMER1 occupies the cytosolic compartment in this Reactome context.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	37	R-HSA-3296477	Defective AMN does not transport GIF:Cbl	yes	reactome/R-HSA-3296477.md	Defective AMN does not transport GIF:Cbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization of AMN at the plasma membrane in the context of cubam-mediated GIF:Cbl uptake (and its defect). Consistent with experimental localization.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	38	R-HSA-264834	Endocytosis and degradation of apoA-I	yes	reactome/R-HSA-264834.md	Endocytosis and degradation of apoA-I	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of AMN at the plasma membrane in the apoA-I endocytosis/degradation pathway (renal cubam reabsorption). Consistent with experimental localization.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	39	R-HSA-264848	apoA-I binds to CUBN:AMN	yes	reactome/R-HSA-264848.md	apoA-I binds to CUBN:AMN	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of AMN at the plasma membrane in the apoA-I binding step of cubam-mediated renal reabsorption. Consistent with experimental localization.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	40	R-HSA-3000103	CUBN:AMN binds CBLIF:RCbl	yes	reactome/R-HSA-3000103.md	CUBN:AMN binds CBLIF:RCbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of AMN at the plasma membrane where CUBN:AMN binds CBLIF:RCbl in the ileum. Consistent with experimental localization.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	41	R-HSA-3000137	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000137.md	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of AMN at the plasma membrane in CUBN:AMN-mediated CBLIF:RCbl uptake and lysosomal delivery. Consistent with experimental localization and endocytic recycling.
human	AMN	genes/human/AMN/AMN-ai-review.yaml	AMN	Q9BXJ7	NCBITaxon:9606	Homo sapiens	42	R-HSA-3296462	Defective CUBN does not transport GIF:Cbl	yes	reactome/R-HSA-3296462.md	Defective CUBN does not transport GIF:Cbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of AMN at the plasma membrane in the defective-CUBN pathway (failed GIF:Cbl transport). Consistent with experimental localization.
human	AMPD1	genes/human/AMPD1/AMPD1-ai-review.yaml	AMPD1	P23109	NCBITaxon:9606	Homo sapiens	11	R-HSA-76590	AMP + H2O => IMP + NH4+ (AMPD)	yes	reactome/R-HSA-76590.md	AMP + H2O => IMP + NH4+ (AMPD)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMP deaminase is a cytosolic enzyme. Reactome curates the AMPD reaction (AMP + H2O => IMP + NH4+) in the cytosol; in skeletal muscle AMPD1 is classically associated with the myofibrillar/contractile apparatus.
human	AMPD2	genes/human/AMPD2/AMPD2-ai-review.yaml	AMPD2	Q01433	NCBITaxon:9606	Homo sapiens	20	R-HSA-76590	AMP + H2O => IMP + NH4+ (AMPD)	yes	reactome/R-HSA-76590.md	AMP + H2O => IMP + NH4+ (AMPD)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of AMP deaminase, asserted by Reactome. Consistent with the known subcellular distribution of the enzyme.
human	AMPD3	genes/human/AMPD3/AMPD3-ai-review.yaml	AMPD3	Q01432	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"This localization derives from the Reactome ""Exocytosis of secretory granule lumen proteins"" neutrophil-degranulation pathway, which catalogs proteins found in neutrophil granule proteomes. AMPD3 is a cytosolic purine-metabolism enzyme; catalog membership in a granule/exocytosis proteome does not establish a bona fide extracellular localization or function for it."
human	AMPD3	genes/human/AMPD3/AMPD3-ai-review.yaml	AMPD3	Q01432	NCBITaxon:9606	Homo sapiens	19	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Same situation as the other extracellular-region annotation, but sourced from the Reactome ""Exocytosis of ficolin-rich granule lumen proteins"" neutrophil-degranulation pathway. AMPD3's presence in this granule-exocytosis proteome does not establish a genuine extracellular localization for a cytosolic AMP deaminase."
human	AMPD3	genes/human/AMPD3/AMPD3-ai-review.yaml	AMPD3	Q01432	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Secretory-granule-lumen localization is asserted from the Reactome neutrophil secretory-granule exocytosis pathway proteome. AMPD3 is a cytosolic homotetrameric AMP deaminase; its appearance in the granule proteome catalog does not establish a genuine luminal granule localization or secretory function.
human	AMPD3	genes/human/AMPD3/AMPD3-ai-review.yaml	AMPD3	Q01432	NCBITaxon:9606	Homo sapiens	21	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Ficolin-1-rich-granule-lumen localization is asserted from the Reactome ficolin-rich granule exocytosis pathway proteome. As with the other granule localizations, this is bulk neutrophil-granule proteome membership for a cytosolic AMP deaminase, not evidence of a bona fide luminal localization or function.
human	AMPD3	genes/human/AMPD3/AMPD3-ai-review.yaml	AMPD3	Q01432	NCBITaxon:9606	Homo sapiens	22	R-HSA-76590	AMP + H2O => IMP + NH4+ (AMPD)	yes	reactome/R-HSA-76590.md	AMP + H2O => IMP + NH4+ (AMPD)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core subcellular localization. AMPD3 is a cytosolic AMP deaminase; the Reactome AMP deaminase reaction module describes cytosolic AMPD activity, and this is consistent with the IBA cytosol annotation from GO_Central.
human	AMT	genes/human/AMT/AMT-ai-review.yaml	AMT	P48728	NCBITaxon:9606	Homo sapiens	8	R-HSA-6783984	Glycine degradation	yes	reactome/R-HSA-6783984.md	Glycine degradation	Homo sapiens	GO:0006546	glycine catabolic process	TAS	involved_in	BP	false		ACCEPT	The curated human glycine-degradation pathway includes the AMT reaction.
human	AMT	genes/human/AMT/AMT-ai-review.yaml	AMT	P48728	NCBITaxon:9606	Homo sapiens	15	R-HSA-5693977	AMT transfers NH2CH2 from GCSH:SAMDLL to THF	yes	reactome/R-HSA-5693977.md	AMT transfers NH2CH2 from GCSH:SAMDLL to THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome explicitly places the human AMT catalyst in the mitochondrial matrix.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	10	R-HSA-174057	Multiubiquitination of APC/C-associated Cdh1	yes	reactome/R-HSA-174057.md	Multiubiquitination of APC/C-associated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for autoubiquitination of APC/C-associated CDH1 (R-HSA-174057), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	11	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for proteasomal degradation of multiubiquitinated CDH1 (R-HSA-174058), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	12	R-HSA-174079	Phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for phosphorylation of CDH1 by cyclin A-CDK2 at the G1/S transition (R-HSA-174079), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	13	R-HSA-174119	Free APC/C phosphorylated by Plk1	yes	reactome/R-HSA-174119.md	Free APC/C phosphorylated by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for phosphorylation of free APC/C by PLK1 (R-HSA-174119), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	14	R-HSA-174132	Free APC/C phosphorylated by Cyclin B:Cdc2	yes	reactome/R-HSA-174132.md	Free APC/C phosphorylated by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for phosphorylation of free APC/C by cyclin B-CDK1 (R-HSA-174132), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	15	R-HSA-174139	Dissociation of phospho-Cdh1 from the APC/C complex	yes	reactome/R-HSA-174139.md	Dissociation of phospho-Cdh1 from the APC/C complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for dissociation of phospho-CDH1 from the APC/C (R-HSA-174139), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	16	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for APC/C-CDH1-mediated degradation of SKP2 (R-HSA-188191), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	17	R-HSA-188371	Association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-188371.md	Association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for association of cyclin A-CDK2 with CDH1 (R-HSA-188371), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	18	R-HSA-3788705	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for CDKN1A (p21) preventing CDH1 phosphorylation by cyclin A-CDK2 (R-HSA-3788705), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	19	R-HSA-3788708	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-3788708.md	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for CDKN1A (p21) preventing cyclin A-CDK2 association with CDH1 (R-HSA-3788708), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	20	R-HSA-3788724	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	yes	reactome/R-HSA-3788724.md	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for ubiquitination of EHMT1 and EHMT2 by APC/C-CDH1 (R-HSA-3788724), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	21	R-HSA-3788725	Cdh1:APC/C complex binds EHMT1:EHMT2	yes	reactome/R-HSA-3788725.md	Cdh1:APC/C complex binds EHMT1:EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for binding of APC/C-CDH1 to EHMT1-EHMT2 (R-HSA-3788725), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	22	R-HSA-68712	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	yes	reactome/R-HSA-68712.md	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for APC/C-CDH1 ubiquitination of geminin, releasing CDT1 (R-HSA-68712), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	23	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for APC/C-CDH1 polyubiquitination of SKP2 (R-HSA-9686969), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	24	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for RB1 recruiting APC/C-CDH1 to SKP2 (R-HSA-9686980), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	25	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (nucleoplasm) for the disease reaction in which defective RB1 fails to bridge SKP2 and FZR1 (R-HSA-9687377), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	35	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for binding of the mitotic checkpoint complex to the APC/C (R-HSA-141423), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	36	R-HSA-174070	Association of Cdh1 with the APC/C	yes	reactome/R-HSA-174070.md	Association of Cdh1 with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of CDH1 with the APC/C in late mitosis (R-HSA-174070), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	37	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of D-box/KEN-box substrates with APC/C-CDH1 (R-HSA-174088), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	38	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for ubiquitination of cyclin A by APC/C-CDC20 (R-HSA-174104), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	39	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for proteasomal degradation of APC/C-multiubiquitinated cell-cycle proteins (R-HSA-174105), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	40	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of cyclin B-CDK1 with APC/C-CDC20 (R-HSA-174120), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	41	R-HSA-174121	Association of Securin with Cdc20:APC/C complex	yes	reactome/R-HSA-174121.md	Association of Securin with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of securin with APC/C-CDC20 (R-HSA-174121), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	42	R-HSA-174144	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174144.md	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for ubiquitination of securin by phospho-APC/C-CDC20 (R-HSA-174144), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	43	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for proteasomal degradation of multiubiquitinated cyclin B (R-HSA-174157), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	44	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of cyclin A with the APC/C (R-HSA-174171), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	45	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for ubiquitination of cell-cycle proteins by APC/C-CDH1 (R-HSA-174195), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	46	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for proteasomal degradation of multiubiquitinated securin (R-HSA-174202), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	47	R-HSA-174224	Dissociation of Cdc20 from APC/C complex	yes	reactome/R-HSA-174224.md	Dissociation of Cdc20 from APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for dissociation of CDC20 from the APC/C in late mitosis (R-HSA-174224), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	48	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for ubiquitination of cyclin B by phospho-APC/C-CDC20 (R-HSA-174227), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	49	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for release of APC/C-CDC20 from the mitotic checkpoint complex (R-HSA-174238), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	50	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for proteasomal degradation of multiubiquitinated cyclin A (R-HSA-174255), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	51	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for association of NEK2A with MCC-bound APC/C (R-HSA-179410), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	52	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for multiubiquitination of NEK2A by APC/C-CDC20 (R-HSA-179417), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	53	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for proteasomal degradation of multiubiquitinated NEK2A (R-HSA-179421), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC11	genes/human/ANAPC11/ANAPC11-ai-review.yaml	ANAPC11	Q9NYG5	NCBITaxon:9606	Homo sapiens	54	R-HSA-69015	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	yes	reactome/R-HSA-69015.md	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for ubiquitination of cytoplasmic phosphorylated CDC6 by the APC/C (R-HSA-69015), an event of the APC/C of which ANAPC11 is the RING catalytic subunit.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	25	R-HSA-174057	Multiubiquitination of APC/C-associated Cdh1	yes	reactome/R-HSA-174057.md	Multiubiquitination of APC/C-associated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	26	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	27	R-HSA-174079	Phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	28	R-HSA-174119	Free APC/C phosphorylated by Plk1	yes	reactome/R-HSA-174119.md	Free APC/C phosphorylated by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	29	R-HSA-174132	Free APC/C phosphorylated by Cyclin B:Cdc2	yes	reactome/R-HSA-174132.md	Free APC/C phosphorylated by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	30	R-HSA-174139	Dissociation of phospho-Cdh1 from the APC/C complex	yes	reactome/R-HSA-174139.md	Dissociation of phospho-Cdh1 from the APC/C complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	31	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	32	R-HSA-188371	Association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-188371.md	Association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	33	R-HSA-3788705	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	34	R-HSA-3788708	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-3788708.md	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	35	R-HSA-3788724	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	yes	reactome/R-HSA-3788724.md	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	36	R-HSA-3788725	Cdh1:APC/C complex binds EHMT1:EHMT2	yes	reactome/R-HSA-3788725.md	Cdh1:APC/C complex binds EHMT1:EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	37	R-HSA-68712	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	yes	reactome/R-HSA-68712.md	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	38	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	39	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	40	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	41	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	42	R-HSA-174070	Association of Cdh1 with the APC/C	yes	reactome/R-HSA-174070.md	Association of Cdh1 with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	43	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	44	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	45	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	46	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	47	R-HSA-174121	Association of Securin with Cdc20:APC/C complex	yes	reactome/R-HSA-174121.md	Association of Securin with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	48	R-HSA-174144	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174144.md	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	49	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	50	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	51	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	52	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	53	R-HSA-174224	Dissociation of Cdc20 from APC/C complex	yes	reactome/R-HSA-174224.md	Dissociation of Cdc20 from APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	54	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	55	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	56	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	57	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	58	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	59	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANAPC2	genes/human/ANAPC2/ANAPC2-ai-review.yaml	ANAPC2	Q9UJX6	NCBITaxon:9606	Homo sapiens	60	R-HSA-69015	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	yes	reactome/R-HSA-69015.md	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is retained as APC/C reaction/localization context rather than a core molecular function.
human	ANG	genes/human/ANG/ANG-ai-review.yaml	ANG	P03950	NCBITaxon:9606	Homo sapiens	22	R-HSA-9708327	ANG cleaves tRNA to yield tRNA halves	no				GO:0004521	RNA endonuclease activity	TAS	enables	MF	false		ACCEPT	Correct. ANG is an RNase A-family RNA endoribonuclease that catalyzes RNA backbone cleavage.
human	ANG	genes/human/ANG/ANG-ai-review.yaml	ANG	P03950	NCBITaxon:9606	Homo sapiens	71	R-HSA-9708296	tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis	no				GO:0016078	tRNA decay	TAS	involved_in	BP	false		ACCEPT	Correct and core. ANG cleaves mature cytoplasmic tRNAs in the anticodon loop to generate tiRNA/tsRNA halves.
human	ANG	genes/human/ANG/ANG-ai-review.yaml	ANG	P03950	NCBITaxon:9606	Homo sapiens	72	R-HSA-9708327	ANG cleaves tRNA to yield tRNA halves	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. ANG has compartment-dependent function across extracellular, nuclear/nucleolar, and cytosolic stress-response pools.
human	ANG	genes/human/ANG/ANG-ai-review.yaml	ANG	P03950	NCBITaxon:9606	Homo sapiens	73	R-HSA-5692437	ANG binds F-actin	no				GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct. ANG has compartment-dependent function across extracellular, nuclear/nucleolar, and cytosolic stress-response pools.
human	ANGPTL3	genes/human/ANGPTL3/ANGPTL3-ai-review.yaml	ANGPTL3	Q9Y5C1	NCBITaxon:9606	Homo sapiens	9	R-HSA-8856525	ANGPTL8 binds ANGPTL3	yes	reactome/R-HSA-8856525.md	ANGPTL8 binds ANGPTL3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The curated reaction places ANGPTL3 with ANGPTL8 extracellularly, consistent with the co-immunoprecipitated circulating complex in PMID:23150577.
human	ANGPTL3	genes/human/ANGPTL3/ANGPTL3-ai-review.yaml	ANGPTL3	Q9Y5C1	NCBITaxon:9606	Homo sapiens	10	R-HSA-9657775	Expression of ANGPTL3 regulated by NR1H2 or NR1H3	yes	reactome/R-HSA-9657775.md	Expression of ANGPTL3 regulated by NR1H2 or NR1H3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The Reactome record describes production of a secreted hepatic protein under nuclear-receptor control.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	9	R-HSA-392751	L1 linked to actin cytoskeleton by ankyrin	yes	reactome/R-HSA-392751.md	L1 linked to actin cytoskeleton by ankyrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	10	R-HSA-443774	Trans-homodimerization of Neurofascin	yes	reactome/R-HSA-443774.md	Trans-homodimerization of Neurofascin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	11	R-HSA-445076	Phosphorylation of Y1229 in L1	yes	reactome/R-HSA-445076.md	Phosphorylation of Y1229 in L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	12	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	13	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	14	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	15	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	16	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK1	genes/human/ANK1/ANK1-ai-review.yaml	ANK1	P16157	NCBITaxon:9606	Homo sapiens	17	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The cytosolic compartment is consistent with ankyrin-mediated complexes.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	24	R-HSA-392751	L1 linked to actin cytoskeleton by ankyrin	yes	reactome/R-HSA-392751.md	L1 linked to actin cytoskeleton by ankyrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	25	R-HSA-445076	Phosphorylation of Y1229 in L1	yes	reactome/R-HSA-445076.md	Phosphorylation of Y1229 in L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	26	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	27	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	28	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	29	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	30	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANK2	genes/human/ANK2/ANK2-ai-review.yaml	ANK2	Q01484	NCBITaxon:9606	Homo sapiens	31	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic ankyrin-B pool is consistent with membrane-trafficking adaptor activity.
human	ANKFY1	genes/human/ANKFY1/ANKFY1-ai-review.yaml	ANKFY1	Q9P2R3	NCBITaxon:9606	Homo sapiens	22	R-HSA-9013438	RHOD binds effectors at the endosome membrane	yes	reactome/R-HSA-9013438.md	RHOD binds effectors at the endosome membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Endosome membrane localization/activity is well supported for ANKFY1/Rabankyrin-5.
human	ANKZF1	genes/human/ANKZF1/ANKZF1-ai-review.yaml	ANKZF1	Q9H8Y5	NCBITaxon:9606	Homo sapiens	4	R-HSA-9948299	Ribosome-associated quality control	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Correct. Reactome places ANKZF1 in the RQC pathway, where it cleaves the tRNA portion of peptidyl-tRNA on stalled-ribosome 60S complexes.
human	ANKZF1	genes/human/ANKZF1/ANKZF1-ai-review.yaml	ANKZF1	Q9H8Y5	NCBITaxon:9606	Homo sapiens	5	R-HSA-9948427	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0004521	RNA endonuclease activity	TAS	enables	MF	false		MODIFY	The activity is correct but the more specific term tRNA-specific ribonuclease activity better captures ANKZF1's substrate and reaction.
human	ANKZF1	genes/human/ANKZF1/ANKZF1-ai-review.yaml	ANKZF1	Q9H8Y5	NCBITaxon:9606	Homo sapiens	6	R-HSA-9948427	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. The RQC substrate and Reactome event are cytosolic ribosome-nascent-chain complexes.
human	ANO10	genes/human/ANO10/ANO10-ai-review.yaml	ANO10	Q9NW15	NCBITaxon:9606	Homo sapiens	6	R-HSA-2684901	ANOs transport cytosolic Cl- to extracellular region	yes	reactome/R-HSA-2684901.md	ANOs transport cytosolic Cl- to extracellular region	Homo sapiens	GO:0005254	chloride channel activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	The historical Reactome channel assignment represents a secondary ion-permeation capability.
human	ANO10	genes/human/ANO10/ANO10-ai-review.yaml	ANO10	Q9NW15	NCBITaxon:9606	Homo sapiens	11	R-HSA-2684901	ANOs transport cytosolic Cl- to extracellular region	yes	reactome/R-HSA-2684901.md	ANOs transport cytosolic Cl- to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The Reactome surface assignment is retained as a context-dependent location.
human	ANO10	genes/human/ANO10/ANO10-ai-review.yaml	ANO10	Q9NW15	NCBITaxon:9606	Homo sapiens	13	R-HSA-983712	Ion channel transport	yes	reactome/R-HSA-983712.md	Ion channel transport	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Ion transport is retained as a secondary capability supported independently of Reactome.
human	ANO5	genes/human/ANO5/ANO5-ai-review.yaml	ANO5	Q75V66	NCBITaxon:9606	Homo sapiens	5	R-HSA-2684901	ANOs transport cytosolic Cl- to extracellular region	yes	reactome/R-HSA-2684901.md	ANOs transport cytosolic Cl- to extracellular region	Homo sapiens	GO:0005254	chloride channel activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	The Reactome channel assertion is retained as a secondary expression-assay activity.
human	ANO5	genes/human/ANO5/ANO5-ai-review.yaml	ANO5	Q75V66	NCBITaxon:9606	Homo sapiens	12	R-HSA-2684901	ANOs transport cytosolic Cl- to extracellular region	yes	reactome/R-HSA-2684901.md	ANOs transport cytosolic Cl- to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome plasma-membrane location is independently supported for ANO5.
human	ANO5	genes/human/ANO5/ANO5-ai-review.yaml	ANO5	Q75V66	NCBITaxon:9606	Homo sapiens	13	R-HSA-9854657	ANO5, ANO6 expose PS, PE on endothelial cells	yes	reactome/R-HSA-9854657.md	ANO5, ANO6 expose PS, PE on endothelial cells	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Surface ANO5 contributes to phospholipid exposure in endothelial cells.
human	ANO5	genes/human/ANO5/ANO5-ai-review.yaml	ANO5	Q75V66	NCBITaxon:9606	Homo sapiens	15	R-HSA-983712	Ion channel transport	yes	reactome/R-HSA-983712.md	Ion channel transport	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ANO5-associated ion transport is retained as a secondary activity.
human	ANOS1	genes/human/ANOS1/ANOS1-ai-review.yaml	ANOS1	P23352	NCBITaxon:9606	Homo sapiens	6	R-HSA-5654514	KAL1 binds FGFR1c	yes	reactome/R-HSA-5654514.md	KAL1 binds FGFR1c	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The FGFR1c binding event occurs extracellularly.
human	ANOS1	genes/human/ANOS1/ANOS1-ai-review.yaml	ANOS1	P23352	NCBITaxon:9606	Homo sapiens	7	R-HSA-5654515	KAL1 binds HS	yes	reactome/R-HSA-5654515.md	KAL1 binds HS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The heparan sulfate binding event occurs extracellularly.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	10	R-HSA-5210909	ANTXR1-bound pagA(197-794) forms oligomers	yes	reactome/R-HSA-5210909.md	ANTXR1-bound pagA(197-794) forms oligomers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Receptor-bound toxin assembly occurs at the plasma membrane.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	11	R-HSA-5210921	pagA binds ANTXR1	yes	reactome/R-HSA-5210921.md	pagA binds ANTXR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ANTXR1 binds protective antigen at the target-cell plasma membrane.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	12	R-HSA-5210923	cya and lef bind to pagA(197-794):ANTXR1 oligomer	yes	reactome/R-HSA-5210923.md	cya and lef bind to pagA(197-794):ANTXR1 oligomer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The receptor-bound PA complex is on the cell surface.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	13	R-HSA-5210935	Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)	yes	reactome/R-HSA-5210935.md	Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Furin processes receptor-bound PA at the cell surface.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	14	R-HSA-5210944	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)	yes	reactome/R-HSA-5210944.md	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The endocytic reaction begins at the plasma membrane.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	19	R-HSA-5210944	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)	yes	reactome/R-HSA-5210944.md	Endocytosis of cya:lef:(pagA(197-794):ANTXR1 oligomer) (plasma membrane to endosome membrane)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The endosomal receptor pool is retained in the toxin-uptake context.
human	ANTXR1	genes/human/ANTXR1/ANTXR1-ai-review.yaml	ANTXR1	Q9H6X2	NCBITaxon:9606	Homo sapiens	20	R-HSA-5210947	pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)	yes	reactome/R-HSA-5210947.md	pagA(197-794):ANTRX1 oligomer transports cya and lef (target cell endosome to cytosol)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The endosomal location is distinct from the PA translocation pore.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	11	R-HSA-5210892	cya and lef bind to pagA(197-794):ANTXR2 oligomer	yes	reactome/R-HSA-5210892.md	cya and lef bind to pagA(197-794):ANTXR2 oligomer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The receptor-bound toxin assembly is at the cell surface.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	12	R-HSA-5210912	Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)	yes	reactome/R-HSA-5210912.md	Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Furin processes receptor-bound protective antigen at the cell surface.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	13	R-HSA-5210918	pagA binds ANTXR2	yes	reactome/R-HSA-5210918.md	pagA binds ANTXR2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated reaction explicitly places human ANTXR2 at the plasma membrane.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	14	R-HSA-5210932	ANTXR2-bound pagA(197-794) forms oligomers	yes	reactome/R-HSA-5210932.md	ANTXR2-bound pagA(197-794) forms oligomers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Receptor-bound protective antigen oligomerizes at the plasma membrane.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	15	R-HSA-5210959	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)	yes	reactome/R-HSA-5210959.md	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The curated uptake reaction starts at the plasma membrane.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	19	R-HSA-5210943	pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)	yes	reactome/R-HSA-5210943.md	pagA(197-794):ANTRX2 oligomer transports cya and lef (target cell endosome to cytosol)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	The endosomal receptor pool is distinct from the protective-antigen pore.
human	ANTXR2	genes/human/ANTXR2/ANTXR2-ai-review.yaml	ANTXR2	P58335	NCBITaxon:9606	Homo sapiens	20	R-HSA-5210959	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)	yes	reactome/R-HSA-5210959.md	Endocytosis of cya:lef:(pagA(197-794):ANTXR2 oligomer) (plasma membrane to endosome membrane)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	The receptor–toxin complex is transported into endosomes.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	31	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for trans-Golgi network coat assembly pathway.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	32	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for VAMP and AP-1 binding with cargo capture.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	33	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for TGN vesicle scission.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	34	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for lysosome vesicle destined coat assembly.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	35	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for lysosomal vesicle scission.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	36	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome annotation for VAMP and AP-1 binding on lysosome destined membrane.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	37	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN-derived lysosomal vesicle uncoating, indicating AP-1 reaches lysosomal membrane during vesicle delivery.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	38	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for lysosomal vesicle scission.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	39	R-HSA-182263	Degradation of MHC I Complex	yes	reactome/R-HSA-182263.md	Degradation of MHC I Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation. AP-1 complex cycles between cytosol and membranes.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	40	R-HSA-182279	Formation of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182279.md	Formation of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MHC I:Nef:AP-1:PACS-1 complex formation.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	41	R-HSA-182286	Transport of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182286.md	Transport of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for transport of MHC I:Nef:AP-1:PACS-1 complex.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	42	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN-lysosomal vesicle coat assembly.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	43	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for vesicle uncoating and release of complex.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	44	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	45	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN vesicle uncoating.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	46	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for lysosomal vesicle uncoating.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	47	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	48	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for dissociation of Arf1:GDP, AP-1 clathrin coated complex.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	49	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN vesicle scission, indicating AP-1 on nascent vesicle.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	50	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN vesicle uncoating.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	51	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TGN-lysosome vesicle translocation.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	52	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	53	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for clathrin:AP1:CLVS binding PI(3,5)P2.
human	AP1B1	genes/human/AP1B1/AP1B1-ai-review.yaml	AP1B1	Q10567	NCBITaxon:9606	Homo sapiens	54	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for dissociation of Arf1:GDP, AP-1 complex.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	1	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	2	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	3	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	4	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	5	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	6	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain Golgi membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	20	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		UNDECIDED	The source-specific lysosomal membrane assertion remains unresolved.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	21	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		UNDECIDED	The source-specific lysosomal membrane assertion remains unresolved.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	30	R-HSA-182263	Degradation of MHC I Complex	yes	reactome/R-HSA-182263.md	Degradation of MHC I Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	31	R-HSA-182279	Formation of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182279.md	Formation of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	32	R-HSA-182286	Transport of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182286.md	Transport of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	33	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	34	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	35	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	36	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	37	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	38	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	39	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain cytosol as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	56	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Retain cytoplasmic vesicle membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	57	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Retain cytoplasmic vesicle membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	67	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Retain trans-Golgi network membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	68	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Retain trans-Golgi network membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	69	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Retain trans-Golgi network membrane as part of AP-1 adaptor function.
human	AP1G1	genes/human/AP1G1/AP1G1-ai-review.yaml	AP1G1	O43747	NCBITaxon:9606	Homo sapiens	70	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Retain trans-Golgi network membrane as part of AP-1 adaptor function.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	1	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'trans-Golgi Network Coat Assembly'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	2	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	3	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'trans-Golgi Network Vesicle Scission'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	4	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	5	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'trans-Golgi Network Lysosomal Vesicle Scission'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	6	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	sigma1A is on the Golgi membrane as part of the AP-1 coat; this row is the Reactome step 'Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	8	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the AP-1 coat on the lysosome-directed carrier ('trans-Golgi Network Derived Lysosomal Vesicle Uncoating').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	9	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the AP-1 coat on the lysosome-directed carrier ('trans-Golgi Network Lysosomal Vesicle Scission').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	13	R-HSA-182263	Degradation of MHC I Complex	yes	reactome/R-HSA-182263.md	Degradation of MHC I Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Degradation of MHC I Complex'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	14	R-HSA-182279	Formation of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182279.md	Formation of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Formation of MHC I:Nef:AP-1:PACS-1 Complex'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	15	R-HSA-182286	Transport of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182286.md	Transport of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Transport of MHC I:Nef:AP-1:PACS-1 Complex'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	16	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'TGN-lysosomal vesicle coat assembly'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	17	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	18	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	19	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'trans-Golgi Network Derived Vesicle Uncoating'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	20	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'trans-Golgi Network Derived Lysosomal Vesicle Uncoating'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	21	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	22	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models the uncoated/unassembled AP-1 pool as cytosolic; this row is the step 'Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex'.
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	39	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome places AP-1 on the budded vesicle membrane ('trans-Golgi Network Vesicle Scission').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	40	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome places AP-1 on the budded vesicle membrane ('trans-Golgi Network Derived Vesicle Uncoating').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	44	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 coat on the TGN membrane ('Translocation of TGN-lysosome vesicle to lysosome').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	45	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 coat on the TGN membrane ('TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	46	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 coat on the TGN membrane ('CLAT:AP1:CLVS bind PI(3,5)P2').
human	AP1S1	genes/human/AP1S1/AP1S1-ai-review.yaml	AP1S1	P61966	NCBITaxon:9606	Homo sapiens	47	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 coat on the TGN membrane ('Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex').
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	1	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 clathrin coat, including the sigma1b variant complex, on the trans-Golgi network membrane during coat assembly. This is the membrane on which AP-1 is recruited and assembled, and it is a core location for the protein.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	2	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Same Golgi membrane location, cited to the Reactome reaction in which AP-1 binds VAMP and TGN membrane while capturing cargo.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	3	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane during TGN vesicle scission, the step at which the assembled coat pinches off a vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	4	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane during assembly of the coat on TGN membrane destined for the lysosome.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	5	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane during scission of the TGN-derived lysosomal vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	6	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane during AP-1 binding and cargo capture on the lysosome-destined Golgi membrane.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	15	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models uncoating of the TGN-derived lysosomal vesicle, which it places at the lysosomal membrane; the AP-1 coat is present at that instant.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	16	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Lysosomal membrane during scission of the TGN-derived lysosomal vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	20	R-HSA-182263	Degradation of MHC I Complex	yes	reactome/R-HSA-182263.md	Degradation of MHC I Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic pool of AP-1, cited to the Reactome MHC class I degradation reaction in the HIV-1 Nef pathway.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	21	R-HSA-182279	Formation of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182279.md	Formation of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to formation of the MHC I:Nef:AP-1:PACS-1 complex.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	22	R-HSA-182286	Transport of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182286.md	Transport of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to transport of the MHC I:Nef:AP-1:PACS-1 complex.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	23	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to TGN-lysosomal vesicle coat assembly - the point at which cytosolic AP-1 is recruited to the membrane.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	24	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to uncoating of the TGN-lysosome vesicle and release of the nonameric complex.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	25	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to VAMP and TGN AP-1 binding coupled with cargo capture.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	26	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to uncoating of the TGN-derived vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	27	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to uncoating of the TGN-derived lysosomal vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	28	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to AP-1 binding and cargo capture on the lysosome-destined Golgi membrane.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	29	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, cited to dissociation of the Arf1:GDP, AP-1 clathrin-coated nonameric complex.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	41	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Cytoplasmic vesicle membrane during TGN vesicle scission, when the coated vesicle separates from the donor membrane.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	42	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Cytoplasmic vesicle membrane during uncoating of the TGN-derived vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	44	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TGN membrane, cited to translocation of the TGN-lysosome vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	45	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TGN membrane, cited to uncoating of the TGN-lysosome vesicle.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	46	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TGN membrane, cited to the reaction in which the clathrin:AP-1:CLVS complex binds PI(3,5)P2.
human	AP1S2	genes/human/AP1S2/AP1S2-ai-review.yaml	AP1S2	P56377	NCBITaxon:9606	Homo sapiens	47	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TGN membrane, cited to dissociation of the Arf1:GDP, AP-1 clathrin-coated nonameric complex.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	1	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome's trans-Golgi Network Coat Assembly reaction places AP-1, with AP1S3 in the sigma slot, on the Golgi membrane as the clathrin coat is nucleated.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	2	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places AP-1 on the Golgi membrane while it binds VAMP cargo and captures it into the forming coat.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	3	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome's trans-Golgi Network Vesicle Scission reaction has the AP-1 coat, including AP1S3, still on the Golgi membrane as the vesicle is released.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	4	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places AP-1 on the Golgi membrane during coat assembly on the lysosome-destined TGN vesicle.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	5	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome's trans-Golgi Network Lysosomal Vesicle Scission reaction has the AP-1 coat on the Golgi membrane at the moment of scission.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	6	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places AP-1 on the lysosome-vesicle-destined Golgi membrane while it binds VAMP and captures cargo.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	10	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome's trans-Golgi Network Derived Lysosomal Vesicle Uncoating reaction places the AP-1 coat at the lysosomal membrane at the moment it is shed.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	11	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome also places the coat at the lysosomal membrane in the lysosomal vesicle scission reaction.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	14	R-HSA-182263	Degradation of MHC I Complex	yes	reactome/R-HSA-182263.md	Degradation of MHC I Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's Degradation of MHC I Complex reaction, part of the HIV-1 Nef pathway, has AP-1 present as a cytosolic complex.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	15	R-HSA-182279	Formation of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182279.md	Formation of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome has cytosolic AP-1 forming the MHC I:Nef:AP-1:PACS-1 complex.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	16	R-HSA-182286	Transport of MHC I:Nef:AP-1:PACS-1 Complex	yes	reactome/R-HSA-182286.md	Transport of MHC I:Nef:AP-1:PACS-1 Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's transport step for the MHC I:Nef:AP-1:PACS-1 complex again lists AP-1 in the cytosol.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	17	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's TGN-lysosomal vesicle coat assembly reaction draws AP-1 from the cytosol onto the membrane.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	18	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome returns AP-1 to the cytosol when the TGN-lysosome vesicle uncoats.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	19	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AP-1 in Reactome's VAMP-binding and cargo-capture reaction at the TGN.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	20	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's trans-Golgi Network Derived Vesicle Uncoating reaction returns AP-1 to the cytosol.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	21	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AP-1 released by uncoating of the TGN-derived lysosomal vesicle.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	22	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic AP-1 in Reactome's cargo-capture reaction on the lysosome-vesicle-destined Golgi membrane.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	23	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's dissociation of the Arf1:GDP, AP-1 clathrin-coated nonameric complex leaves AP-1 in the cytosol.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	35	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the AP-1 coat on the membrane of the vesicle being released from the TGN.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	36	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome's TGN-derived vesicle uncoating reaction has AP-1 on the vesicle membrane until it is shed.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	39	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome's translocation of the TGN-lysosome vesicle places the AP-1 coat at the trans-Golgi network membrane.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	40	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome's TGN-lysosome vesicle uncoating reaction also lists the trans-Golgi network membrane.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	41	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome's CLAT:AP1:CLVS bind PI(3,5)P2 reaction places the clathrin/AP-1 coat at the trans-Golgi network membrane.
human	AP1S3	genes/human/AP1S3/AP1S3-ai-review.yaml	AP1S3	Q96PC3	NCBITaxon:9606	Homo sapiens	42	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome's dissociation of the Arf1:GDP, AP-1 clathrin-coated nonameric complex is placed at the trans-Golgi network membrane.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	65	R-HSA-190519	Internalization of gap junction plaques	yes	reactome/R-HSA-190519.md	Internalization of gap junction plaques	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	66	R-HSA-190829	Lysosomal degradation of gap junction plaques	yes	reactome/R-HSA-190829.md	Lysosomal degradation of gap junction plaques	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	68	R-HSA-167537	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167537.md	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	69	R-HSA-167597	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167597.md	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	70	R-HSA-167601	Degradation of CD4	yes	reactome/R-HSA-167601.md	Degradation of CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	71	R-HSA-167637	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	yes	reactome/R-HSA-167637.md	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	72	R-HSA-182171	Degradation of CD8	yes	reactome/R-HSA-182171.md	Degradation of CD8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	73	R-HSA-182186	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182186.md	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	74	R-HSA-182198	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182198.md	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	75	R-HSA-3928654	Clathrin internalises EPH:EFN complexes	yes	reactome/R-HSA-3928654.md	Clathrin internalises EPH:EFN complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	76	R-HSA-5138433	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	yes	reactome/R-HSA-5138433.md	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	77	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	78	R-HSA-8856808	Recruitment of AP-2 complex and clathrin	yes	reactome/R-HSA-8856808.md	Recruitment of AP-2 complex and clathrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	79	R-HSA-8856813	AAK1 phosphorylates AP-2 mu subunit at T156	yes	reactome/R-HSA-8856813.md	AAK1 phosphorylates AP-2 mu subunit at T156	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	80	R-HSA-8862280	FCHo proteins bind nascent clathrin-coated pit	yes	reactome/R-HSA-8862280.md	FCHo proteins bind nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	81	R-HSA-8866277	AP-2 directly binds some endocytic cargo	yes	reactome/R-HSA-8866277.md	AP-2 directly binds some endocytic cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	82	R-HSA-8866283	ARBB recruits GPCRs into clathrin-coated pits	yes	reactome/R-HSA-8866283.md	ARBB recruits GPCRs into clathrin-coated pits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	83	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	84	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	85	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	86	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	87	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	88	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	89	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	90	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	91	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	92	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	93	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	94	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	95	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	96	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	97	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	98	R-HSA-8871196	Initial binding of AP-2 and clathrin to PI(4,5)P2	yes	reactome/R-HSA-8871196.md	Initial binding of AP-2 and clathrin to PI(4,5)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	99	R-HSA-9681616	AP2 binds chlorpromazine	yes	reactome/R-HSA-9681616.md	AP2 binds chlorpromazine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the cytosolic coat/adaptor pool in this pathway event.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	104	R-HSA-167633	Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex	yes	reactome/R-HSA-167633.md	Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	105	R-HSA-167637	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	yes	reactome/R-HSA-167637.md	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	106	R-HSA-177479	Axonal transport of NGF:Trk complexes	yes	reactome/R-HSA-177479.md	Axonal transport of NGF:Trk complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	107	R-HSA-190519	Internalization of gap junction plaques	yes	reactome/R-HSA-190519.md	Internalization of gap junction plaques	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	108	R-HSA-196017	Dynamin is recruited to the gap junction plaque	yes	reactome/R-HSA-196017.md	Dynamin is recruited to the gap junction plaque	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	109	R-HSA-196026	Dab2 is recruited to the junctional plaques	yes	reactome/R-HSA-196026.md	Dab2 is recruited to the junctional plaques	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	110	R-HSA-2130640	Recruitment of clathrin coated vesicle by Ii	yes	reactome/R-HSA-2130640.md	Recruitment of clathrin coated vesicle by Ii	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	111	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	112	R-HSA-392748	L1 binds to AP-2 Clathrin complex	yes	reactome/R-HSA-392748.md	L1 binds to AP-2 Clathrin complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	113	R-HSA-392749	Transport of L1 into endosomes	yes	reactome/R-HSA-392749.md	Transport of L1 into endosomes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	114	R-HSA-445071	Reinsertion of L1 into the plasma membrane	yes	reactome/R-HSA-445071.md	Reinsertion of L1 into the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	115	R-HSA-445079	Phosphorylation of L1 by ERK	yes	reactome/R-HSA-445079.md	Phosphorylation of L1 by ERK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	116	R-HSA-555065	Formation of clathrin coated vesicle	yes	reactome/R-HSA-555065.md	Formation of clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	117	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	118	R-HSA-6784735	PCSK9:LDLR bind to Clathrin	yes	reactome/R-HSA-6784735.md	PCSK9:LDLR bind to Clathrin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	119	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	120	R-HSA-8855131	VLDLR:PCSK9 binds Clathrin-coated vesicles	yes	reactome/R-HSA-8855131.md	VLDLR:PCSK9 binds Clathrin-coated vesicles	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	121	R-HSA-8866279	Epsin family proteins bind ubiquitinated cargo	yes	reactome/R-HSA-8866279.md	Epsin family proteins bind ubiquitinated cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	122	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	123	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	124	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	125	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	126	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	127	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	128	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	129	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	130	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Retain the plasma-membrane-associated AP-2 pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	147	R-HSA-416639	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	yes	reactome/R-HSA-416639.md	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Retain the transient endocytic carrier membrane pool.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	148	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Retain association with forming clathrin-coated endocytic carriers.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	154	R-HSA-2130486	Uncoating of clathrin-coated vesicles and fusion with endosomes	yes	reactome/R-HSA-2130486.md	Uncoating of clathrin-coated vesicles and fusion with endosomes	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	155	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	156	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	157	R-HSA-6784738	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	yes	reactome/R-HSA-6784738.md	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2M1	genes/human/AP2M1/AP2M1-ai-review.yaml	AP2M1	Q96CW1	NCBITaxon:9606	Homo sapiens	158	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		UNDECIDED	Destination-membrane localization is not resolved by the available event record.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	9	R-HSA-167537	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167537.md	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-167537), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	10	R-HSA-167597	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167597.md	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-167597), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	11	R-HSA-167601	Degradation of CD4	yes	reactome/R-HSA-167601.md	Degradation of CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-167601), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	12	R-HSA-182171	Degradation of CD8	yes	reactome/R-HSA-182171.md	Degradation of CD8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-182171), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	13	R-HSA-182186	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182186.md	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-182186), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	14	R-HSA-182198	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182198.md	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-182198), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	15	R-HSA-3928654	Clathrin internalises EPH:EFN complexes	yes	reactome/R-HSA-3928654.md	Clathrin internalises EPH:EFN complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-3928654), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	16	R-HSA-5138433	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	yes	reactome/R-HSA-5138433.md	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-5138433), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	17	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-5138459), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	18	R-HSA-8856808	Recruitment of AP-2 complex and clathrin	yes	reactome/R-HSA-8856808.md	Recruitment of AP-2 complex and clathrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8856808), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	19	R-HSA-8856813	AAK1 phosphorylates AP-2 mu subunit at T156	yes	reactome/R-HSA-8856813.md	AAK1 phosphorylates AP-2 mu subunit at T156	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8856813), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	20	R-HSA-8862280	FCHo proteins bind nascent clathrin-coated pit	yes	reactome/R-HSA-8862280.md	FCHo proteins bind nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8862280), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	21	R-HSA-8866277	AP-2 directly binds some endocytic cargo	yes	reactome/R-HSA-8866277.md	AP-2 directly binds some endocytic cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8866277), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	22	R-HSA-8866283	ARBB recruits GPCRs into clathrin-coated pits	yes	reactome/R-HSA-8866283.md	ARBB recruits GPCRs into clathrin-coated pits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8866283), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	23	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8867754), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	24	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8867756), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	25	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868071), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	26	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868072), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	27	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868230), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	28	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868236), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	29	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868648), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	30	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868651), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	31	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868658), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	32	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868659), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	33	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868660), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	34	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8868661), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	35	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8869438), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	36	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8871193), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	37	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8871194), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	38	R-HSA-8871196	Initial binding of AP-2 and clathrin to PI(4,5)P2	yes	reactome/R-HSA-8871196.md	Initial binding of AP-2 and clathrin to PI(4,5)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-8871196), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	39	R-HSA-9681616	AP2 binds chlorpromazine	yes	reactome/R-HSA-9681616.md	AP2 binds chlorpromazine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of thirty-one identical Reactome cytosol rows. The underlying biology is real -- AP-2 is assembled in the cytosol and cycles between a soluble pool and the membrane -- but this row is a participant-compartment assignment attached to a Reactome reaction (Reactome:R-HSA-9681616), not an observation about AP2S1.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	42	R-HSA-177479	Axonal transport of NGF:Trk complexes	yes	reactome/R-HSA-177479.md	Axonal transport of NGF:Trk complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-177479). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	43	R-HSA-2130640	Recruitment of clathrin coated vesicle by Ii	yes	reactome/R-HSA-2130640.md	Recruitment of clathrin coated vesicle by Ii	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-2130640). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	44	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-2130725). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	45	R-HSA-392748	L1 binds to AP-2 Clathrin complex	yes	reactome/R-HSA-392748.md	L1 binds to AP-2 Clathrin complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-392748). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	46	R-HSA-392749	Transport of L1 into endosomes	yes	reactome/R-HSA-392749.md	Transport of L1 into endosomes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-392749). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	47	R-HSA-445071	Reinsertion of L1 into the plasma membrane	yes	reactome/R-HSA-445071.md	Reinsertion of L1 into the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-445071). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	48	R-HSA-445079	Phosphorylation of L1 by ERK	yes	reactome/R-HSA-445079.md	Phosphorylation of L1 by ERK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-445079). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	49	R-HSA-555065	Formation of clathrin coated vesicle	yes	reactome/R-HSA-555065.md	Formation of clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-555065). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	50	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-6784729). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	51	R-HSA-6784735	PCSK9:LDLR bind to Clathrin	yes	reactome/R-HSA-6784735.md	PCSK9:LDLR bind to Clathrin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-6784735). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	52	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8855130). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	53	R-HSA-8855131	VLDLR:PCSK9 binds Clathrin-coated vesicles	yes	reactome/R-HSA-8855131.md	VLDLR:PCSK9 binds Clathrin-coated vesicles	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8855131). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	54	R-HSA-8866279	Epsin family proteins bind ubiquitinated cargo	yes	reactome/R-HSA-8866279.md	Epsin family proteins bind ubiquitinated cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8866279). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	55	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8867754). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	56	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8867756). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	57	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868071). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	58	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868072). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	59	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868230). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	60	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868236). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	61	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868648). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	62	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868651). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	63	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	One of twenty-two Reactome plasma-membrane rows (Reactome:R-HSA-8868661). Unlike the cytosol and endolysosome rows, the compartment this one assigns is exactly where AP-2 works.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	77	R-HSA-416639	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	yes	reactome/R-HSA-416639.md	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome row from R-HSA-416639 'Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites', placing AP2S1 on the endocytic vesicle membrane.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	78	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome row from R-HSA-5138459 'WNT5A:FZD4 is endocytosed', placing AP2S1 on the clathrin-coated endocytic vesicle membrane.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	81	R-HSA-2130486	Uncoating of clathrin-coated vesicles and fusion with endosomes	yes	reactome/R-HSA-2130486.md	Uncoating of clathrin-coated vesicles and fusion with endosomes	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		REMOVE	One of five Reactome rows placing AP2S1 in the endolysosome membrane, from Reactome:R-HSA-2130486. Reading the cached Reactome entries shows what produced them: these are reactions in which a clathrin-coated-vesicle entity is relocated to a downstream compartment while keeping its full subunit roster -- 'Uncoating of clathrin-coated vesicles and fusion with endosomes' (R-HSA-2130486), 'PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome' (R-HSA-6784729), 'VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane' (R-HSA-8855130). The first of those is literally the step at which AP-2 leaves.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	82	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		REMOVE	One of five Reactome rows placing AP2S1 in the endolysosome membrane, from Reactome:R-HSA-2130725. Reading the cached Reactome entries shows what produced them: these are reactions in which a clathrin-coated-vesicle entity is relocated to a downstream compartment while keeping its full subunit roster -- 'Uncoating of clathrin-coated vesicles and fusion with endosomes' (R-HSA-2130486), 'PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome' (R-HSA-6784729), 'VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane' (R-HSA-8855130). The first of those is literally the step at which AP-2 leaves.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	83	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		REMOVE	One of five Reactome rows placing AP2S1 in the endolysosome membrane, from Reactome:R-HSA-6784729. Reading the cached Reactome entries shows what produced them: these are reactions in which a clathrin-coated-vesicle entity is relocated to a downstream compartment while keeping its full subunit roster -- 'Uncoating of clathrin-coated vesicles and fusion with endosomes' (R-HSA-2130486), 'PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome' (R-HSA-6784729), 'VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane' (R-HSA-8855130). The first of those is literally the step at which AP-2 leaves.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	84	R-HSA-6784738	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	yes	reactome/R-HSA-6784738.md	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		REMOVE	One of five Reactome rows placing AP2S1 in the endolysosome membrane, from Reactome:R-HSA-6784738. Reading the cached Reactome entries shows what produced them: these are reactions in which a clathrin-coated-vesicle entity is relocated to a downstream compartment while keeping its full subunit roster -- 'Uncoating of clathrin-coated vesicles and fusion with endosomes' (R-HSA-2130486), 'PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome' (R-HSA-6784729), 'VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane' (R-HSA-8855130). The first of those is literally the step at which AP-2 leaves.
human	AP2S1	genes/human/AP2S1/AP2S1-ai-review.yaml	AP2S1	P53680	NCBITaxon:9606	Homo sapiens	85	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		REMOVE	One of five Reactome rows placing AP2S1 in the endolysosome membrane, from Reactome:R-HSA-8855130. Reading the cached Reactome entries shows what produced them: these are reactions in which a clathrin-coated-vesicle entity is relocated to a downstream compartment while keeping its full subunit roster -- 'Uncoating of clathrin-coated vesicles and fusion with endosomes' (R-HSA-2130486), 'PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome' (R-HSA-6784729), 'VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane' (R-HSA-8855130). The first of those is literally the step at which AP-2 leaves.
human	AP4B1	genes/human/AP4B1/AP4B1-ai-review.yaml	AP4B1	Q9Y6B7	NCBITaxon:9606	Homo sapiens	24	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""AP4 transports APP from trans-Golgi network to endosome lumen."" This represents the destination of AP-4-mediated cargo transport."
human	AP4B1	genes/human/AP4B1/AP4B1-ai-review.yaml	AP4B1	Q9Y6B7	NCBITaxon:9606	Homo sapiens	25	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome showing AP-4 localization to TGN membrane where it initiates cargo sorting.
human	AP4B1	genes/human/AP4B1/AP4B1-ai-review.yaml	AP4B1	Q9Y6B7	NCBITaxon:9606	Homo sapiens	26	R-HSA-5229132	AP4 binds APP	yes	reactome/R-HSA-5229132.md	AP4 binds APP	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""AP4 binds APP"" showing AP-4 at TGN membrane where cargo recognition occurs."
human	AP4E1	genes/human/AP4E1/AP4E1-ai-review.yaml	AP4E1	Q9UPM8	NCBITaxon:9606	Homo sapiens	21	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		REMOVE	The cargo destination in the Reactome event does not place epsilon inside the endosome lumen.
human	AP4E1	genes/human/AP4E1/AP4E1-ai-review.yaml	AP4E1	Q9UPM8	NCBITaxon:9606	Homo sapiens	22	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	AP-4 assembles at the trans-Golgi network membrane.
human	AP4E1	genes/human/AP4E1/AP4E1-ai-review.yaml	AP4E1	Q9UPM8	NCBITaxon:9606	Homo sapiens	23	R-HSA-5229132	AP4 binds APP	yes	reactome/R-HSA-5229132.md	AP4 binds APP	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	AP-4 assembles at the trans-Golgi network membrane.
human	AP4M1	genes/human/AP4M1/AP4M1-ai-review.yaml	AP4M1	O00189	NCBITaxon:9606	Homo sapiens	29	R-HSA-199992	trans-Golgi Network Vesicle Budding	yes	reactome/R-HSA-199992.md	trans-Golgi Network Vesicle Budding	Homo sapiens	GO:0006892	post-Golgi vesicle-mediated transport	TAS	involved_in	BP	false		ACCEPT	A correct, broad process term attached through a Reactome pathway whose own narrative is about clathrin coats nucleated by AP-1 rather than about AP-4.
human	AP4M1	genes/human/AP4M1/AP4M1-ai-review.yaml	AP4M1	O00189	NCBITaxon:9606	Homo sapiens	33	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0008320	transmembrane protein transporter activity	TAS	enables	MF	false		REMOVE	Asserts that AP4M1 moves a protein from one side of a membrane to the other. It does not. AP-4 selects cargo into vesicles; nothing crosses a bilayer.
human	AP4M1	genes/human/AP4M1/AP4M1-ai-review.yaml	AP4M1	O00189	NCBITaxon:9606	Homo sapiens	44	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		REMOVE	Places the adaptor inside the endosome. AP4M1 is a cytosolic, peripheral-membrane coat subunit; the lumen is where its cargo ends up in Reactome's model, not where the protein is.
human	AP4M1	genes/human/AP4M1/AP4M1-ai-review.yaml	AP4M1	O00189	NCBITaxon:9606	Homo sapiens	45	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	The membrane-level refinement of the core localization, and the most precise cellular-component term on this gene.
human	AP4M1	genes/human/AP4M1/AP4M1-ai-review.yaml	AP4M1	O00189	NCBITaxon:9606	Homo sapiens	46	R-HSA-5229132	AP4 binds APP	yes	reactome/R-HSA-5229132.md	AP4 binds APP	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	The same membrane localization from the binding reaction rather than the transport reaction. Correct.
human	AP4S1	genes/human/AP4S1/AP4S1-ai-review.yaml	AP4S1	Q9Y587	NCBITaxon:9606	Homo sapiens	12	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		REMOVE	Topologically impossible, and traceable to a specific mechanism: Reactome models the reaction's output as the complex AP4:APP sitting in compartment 'endosome lumen', and the Reactome-to-GO mapping gives that compartment to every member of the complex. AP-4 is a cytosolic peripheral membrane coat and never enters a lumen.
human	AP4S1	genes/human/AP4S1/AP4S1-ai-review.yaml	AP4S1	Q9Y587	NCBITaxon:9606	Homo sapiens	13	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	The same Reactome projection as the endosome lumen row, but reaching the right answer: the reaction's input complex is placed at the trans-Golgi network membrane, which is where AP-4 assembles.
human	AP4S1	genes/human/AP4S1/AP4S1-ai-review.yaml	AP4S1	Q9Y587	NCBITaxon:9606	Homo sapiens	14	R-HSA-5229132	AP4 binds APP	yes	reactome/R-HSA-5229132.md	AP4 binds APP	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	The trans-Golgi network membrane term again, from the companion Reactome reaction in which AP-4 binds APP. Every participant in that reaction is placed at the TGN membrane, which is correct.
human	APBB1	genes/human/APBB1/APBB1-ai-review.yaml	APBB1	O00213	NCBITaxon:9606	Homo sapiens	41	R-HSA-5683986	APBB1 and MAPK8 bind diphosphorylated H2AFX	yes	reactome/R-HSA-5683986.md	APBB1 and MAPK8 bind diphosphorylated H2AFX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for nucleoplasm localization in the context of H2AX binding pathway.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	125	R-HSA-3361751	beta-catenin is replaced by repression complexes at the promoter	yes	reactome/R-HSA-3361751.md	beta-catenin is replaced by repression complexes at the promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is supported but secondary to APC’s principal activities.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	126	R-HSA-3364042	APC promotes disassembly of beta-catenin transactivation complex	yes	reactome/R-HSA-3364042.md	APC promotes disassembly of beta-catenin transactivation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm is supported but secondary to APC’s principal activities.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	133	R-HSA-195251	Assembly of the destruction complex	yes	reactome/R-HSA-195251.md	Assembly of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	134	R-HSA-195275	Phosphorylation of APC component of the destruction complex	yes	reactome/R-HSA-195275.md	Phosphorylation of APC component of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	135	R-HSA-195280	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	yes	reactome/R-HSA-195280.md	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	136	R-HSA-195283	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	yes	reactome/R-HSA-195283.md	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	137	R-HSA-195287	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	yes	reactome/R-HSA-195287.md	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	138	R-HSA-195300	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	yes	reactome/R-HSA-195300.md	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	139	R-HSA-195304	Association of beta-catenin with the destruction complex	yes	reactome/R-HSA-195304.md	Association of beta-catenin with the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	140	R-HSA-195318	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	yes	reactome/R-HSA-195318.md	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	141	R-HSA-201685	Beta-catenin is released from the destruction complex	yes	reactome/R-HSA-201685.md	Beta-catenin is released from the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	142	R-HSA-202947	Caspase mediated cleavage of APC	yes	reactome/R-HSA-202947.md	Caspase mediated cleavage of APC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	143	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	144	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	145	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	146	R-HSA-4791278	APC truncation mutants have impaired AXIN binding	yes	reactome/R-HSA-4791278.md	APC truncation mutants have impaired AXIN binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	147	R-HSA-4827388	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	yes	reactome/R-HSA-4827388.md	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	148	R-HSA-4839634	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839634.md	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	149	R-HSA-4839635	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839635.md	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	150	R-HSA-4839638	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839638.md	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	151	R-HSA-4839734	AXIN mutants destabilize the destruction complex	yes	reactome/R-HSA-4839734.md	AXIN mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	152	R-HSA-4839746	Truncated AMER1 mutants destabilize the destruction complex	yes	reactome/R-HSA-4839746.md	Truncated AMER1 mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	153	R-HSA-5229343	AXIN is phosphorylated in the destruction complex	yes	reactome/R-HSA-5229343.md	AXIN is phosphorylated in the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	154	R-HSA-5246693	APC is K63-polyubiquitinated	yes	reactome/R-HSA-5246693.md	APC is K63-polyubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	155	R-HSA-5246696	APC truncation mutants are not K63 polyubiquitinated	yes	reactome/R-HSA-5246696.md	APC truncation mutants are not K63 polyubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	156	R-HSA-5339713	Misspliced GSK3beta mutants stabilize beta-catenin levels	yes	reactome/R-HSA-5339713.md	Misspliced GSK3beta mutants stabilize beta-catenin levels	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	157	R-HSA-6781905	ZRANB1 binds APC	yes	reactome/R-HSA-6781905.md	ZRANB1 binds APC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	158	R-NUL-209060	Human APC is further phosphorylated by Murine GSK3beta	yes	reactome/R-NUL-209060.md	Human APC is further phosphorylated by Murine GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	159	R-NUL-209065	Human APC is further phosphorylated by Murine CKIepsilon	yes	reactome/R-NUL-209065.md	Human APC is further phosphorylated by Murine CKIepsilon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	160	R-NUL-209132	Human APC is initially phosphorylated by Murine CKIepsilon	yes	reactome/R-NUL-209132.md	Human APC is initially phosphorylated by Murine CKIepsilon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APC	genes/human/APC/APC-ai-review.yaml	APC	P25054	NCBITaxon:9606	Homo sapiens	161	R-NUL-209144	Human APC is finally phosphorylated by Murine GSK3beta	yes	reactome/R-NUL-209144.md	Human APC is finally phosphorylated by Murine GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol fits the established APC function or location.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	78	R-HSA-73933	Resolution of Abasic Sites (AP sites)	yes	reactome/R-HSA-73933.md	Resolution of Abasic Sites (AP sites)	Homo sapiens	GO:0006287	base-excision repair, gap-filling	TAS	involved_in	BP	false		ACCEPT	APEX1 participates in BER gap-filling by coordinating with DNA polymerase beta after AP site incision.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	79	R-HSA-110359	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site	yes	reactome/R-HSA-110359.md	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site	Homo sapiens	GO:0004520	DNA endonuclease activity	TAS	enables	MF	false		ACCEPT	APEX1 has DNA endonuclease activity, cleaving at AP sites.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	80	R-HSA-110349	Displacement of UNG glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110349.md	Displacement of UNG glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	APEX1 localizes to nucleoplasm for BER function.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	81	R-HSA-110350	Displacement of TDG glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110350.md	Displacement of TDG glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome TDG displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	82	R-HSA-110351	Displacement of SMUG1 glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110351.md	Displacement of SMUG1 glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome SMUG1 displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	83	R-HSA-110352	Displacement of NTHL1 glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110352.md	Displacement of NTHL1 glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome NTHL1 displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	84	R-HSA-110353	Displacement of MBD4 glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110353.md	Displacement of MBD4 glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome MBD4 displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	85	R-HSA-110354	Displacement of OGG1 glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110354.md	Displacement of OGG1 glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome OGG1 displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	86	R-HSA-110355	Displacement of MUTYH glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110355.md	Displacement of MUTYH glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome MUTYH displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	87	R-HSA-110356	Displacement of MPG glycosylase by APEX1 at the AP site	yes	reactome/R-HSA-110356.md	Displacement of MPG glycosylase by APEX1 at the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome MPG displacement reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	88	R-HSA-110359	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site	yes	reactome/R-HSA-110359.md	APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome AP site cleavage reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	89	R-HSA-110360	Recruitment of POLB to the AP site	yes	reactome/R-HSA-110360.md	Recruitment of POLB to the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome POLB recruitment.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	90	R-HSA-110363	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	yes	reactome/R-HSA-110363.md	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome FEN1 cleavage reaction.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	91	R-HSA-110364	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	yes	reactome/R-HSA-110364.md	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome long-patch BER.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	92	R-HSA-110368	POLD,POLE-mediated DNA strand displacement synthesis	yes	reactome/R-HSA-110368.md	POLD,POLE-mediated DNA strand displacement synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome strand displacement.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	93	R-HSA-110371	LIG1 binds APEX1 and PCNA at SSB	yes	reactome/R-HSA-110371.md	LIG1 binds APEX1 and PCNA at SSB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome LIG1 binding.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	94	R-HSA-110375	Excision of the abasic sugar phosphate (5'dRP) residue	yes	reactome/R-HSA-110375.md	Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome dRP excision.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	95	R-HSA-111253	POLB incorporates the first 3' dNMP and displaces 5'ddRP	yes	reactome/R-HSA-111253.md	POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome POLB incorporation.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	96	R-HSA-5649854	Recruitment of POLB to oxidatively damaged AP site	yes	reactome/R-HSA-5649854.md	Recruitment of POLB to oxidatively damaged AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome oxidatively damaged AP site.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	97	R-HSA-5649856	Oxidative damage to the AP site	yes	reactome/R-HSA-5649856.md	Oxidative damage to the AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome oxidative damage.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	98	R-HSA-5649873	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1	yes	reactome/R-HSA-5649873.md	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome PARP binding.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	99	R-HSA-5651805	LIG1 bound to APEX1 and PCNA ligates SSB	yes	reactome/R-HSA-5651805.md	LIG1 bound to APEX1 and PCNA ligates SSB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome ligation.
human	APEX1	genes/human/APEX1/APEX1-ai-review.yaml	APEX1	P27695	NCBITaxon:9606	Homo sapiens	100	R-HSA-5651809	LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA	yes	reactome/R-HSA-5651809.md	LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome dissociation.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	46	R-HSA-9010096	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	yes	reactome/R-HSA-9010096.md	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1A as a multipass gamma-secretase subunit, especially its ER/cis-Golgi localization.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	56	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	57	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	58	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	59	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	60	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	61	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	62	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	63	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	64	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1A	genes/human/APH1A/APH1A-ai-review.yaml	APH1A	Q96BI3	NCBITaxon:9606	Homo sapiens	65	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane annotations are plausible for gamma-secretase substrate events, but APH1A-specific steady-state localization is strongest for ER and cis-Golgi membranes.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	29	R-HSA-9010096	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	yes	reactome/R-HSA-9010096.md	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	30	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	31	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	32	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	33	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	34	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	35	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	36	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	37	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	38	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APH1B	genes/human/APH1B/APH1B-ai-review.yaml	APH1B	Q8WW43	NCBITaxon:9606	Homo sapiens	39	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with APH1B as a multipass gamma-secretase subunit; cell-surface Aph-1 localization is also directly reported.
human	APIP	genes/human/APIP/APIP-ai-review.yaml	APIP	Q96GX9	NCBITaxon:9606	Homo sapiens	33	R-HSA-6804596	APAF1:CYCS binds APIP	yes	reactome/R-HSA-6804596.md	APAF1:CYCS binds APIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for APIP binding to the apoptosome complex (APAF1:CYCS). Cytosolic localization is consistent with immunofluorescence data (PMID:23285211).
human	APLN	genes/human/APLN/APLN-ai-review.yaml	APLN	Q9ULZ1	NCBITaxon:9606	Homo sapiens	12	R-HSA-374337	Apelin receptor binds to apelin	yes	reactome/R-HSA-374337.md	Apelin receptor binds to apelin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places apelin extracellularly in its reaction for apelin binding to its receptor.
human	APLN	genes/human/APLN/APLN-ai-review.yaml	APLN	Q9ULZ1	NCBITaxon:9606	Homo sapiens	13	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places apelin extracellularly in its reaction for the liganded receptor acting as a GEF for Gi.
human	APLN	genes/human/APLN/APLN-ai-review.yaml	APLN	Q9ULZ1	NCBITaxon:9606	Homo sapiens	14	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places apelin extracellularly in its reaction for dissociation of the ligand:GPCR:Gi complex.
human	APLN	genes/human/APLN/APLN-ai-review.yaml	APLN	Q9ULZ1	NCBITaxon:9606	Homo sapiens	15	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places apelin extracellularly in its reaction for the liganded receptor binding inactive Gi.
human	APOC4	genes/human/APOC4/APOC4-ai-review.yaml	APOC4	P55056	NCBITaxon:9606	Homo sapiens	26	R-HSA-8854408	APOBR dimer binds VLDLs	yes	reactome/R-HSA-8854408.md	APOBR dimer binds VLDLs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement from 'APOBR dimer binds VLDLs' (Reactome:R-HSA-8854408) placing the secreted APOC4 protein in the extracellular region. APOC4 appears in this Reactome reaction as a component of the VLDL particle that the macrophage apolipoprotein B receptor binds. The extracellular-region assignment follows from the particle being in blood.
human	APOC4	genes/human/APOC4/APOC4-ai-review.yaml	APOC4	P55056	NCBITaxon:9606	Homo sapiens	27	R-HSA-8854462	VLDLR binds VLDL	yes	reactome/R-HSA-8854462.md	VLDLR binds VLDL	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement from 'VLDLR binds VLDL' (Reactome:R-HSA-8854462) placing the secreted APOC4 protein in the extracellular region. APOC4 appears here as a constituent of the VLDL particle bound by VLDLR; the Reactome summary cites Kotite et al. 2003 for apoC-IV being a minor VLDL constituent, which is the same evidence as the IDA row.
human	APOC4	genes/human/APOC4/APOC4-ai-review.yaml	APOC4	P55056	NCBITaxon:9606	Homo sapiens	28	R-HSA-8866321	VLDL binds APOC1 and APOC4	yes	reactome/R-HSA-8866321.md	VLDL binds APOC1 and APOC4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement from 'VLDL binds APOC1 and APOC4' (Reactome:R-HSA-8866321) placing the secreted APOC4 protein in the extracellular region. This is the reaction in which APOC4 is the participant rather than a bystander: newly secreted VLDL acquiring apoC-I and apoC-IV in the circulation, again citing Kotite et al. 2003.
human	APOC4	genes/human/APOC4/APOC4-ai-review.yaml	APOC4	P55056	NCBITaxon:9606	Homo sapiens	29	R-HSA-9035279	Expression of APOC4 regulated by NR1H2 or NR1H3	yes	reactome/R-HSA-9035279.md	Expression of APOC4 regulated by NR1H2 or NR1H3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement from 'Expression of APOC4 regulated by NR1H2 or NR1H3' (Reactome:R-HSA-9035279) placing the secreted APOC4 protein in the extracellular region. A gene-expression event - liver X receptors inducing the APOE/APOC1/APOC2/APOC4 cluster in macrophages - in which the APOC4 protein is the product. The extracellular-region assignment is for the secreted product.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	64	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	retinoid metabolic process is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	68	R-HSA-2423785	CR:atREs binds apoE and HSPG	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0050750	low-density lipoprotein particle receptor binding	TAS	enables	MF	false		ACCEPT	APOE low-density lipoprotein particle receptor binding supports receptor- or proteoglycan-dependent uptake of APOE-containing lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	101	R-HSA-976734	Amyloid fibrils have additional components	yes	reactome/R-HSA-976734.md	Amyloid fibrils have additional components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	178	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	213	R-HSA-174657	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex	yes	reactome/R-HSA-174657.md	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	214	R-HSA-174660	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron	yes	reactome/R-HSA-174660.md	nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	215	R-HSA-174690	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III	yes	reactome/R-HSA-174690.md	TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	216	R-HSA-174739	chylomicron remnant + apoE => chylomicron remnant:apoE complex	yes	reactome/R-HSA-174739.md	chylomicron remnant + apoE => chylomicron remnant:apoE complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	217	R-HSA-174757	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols	yes	reactome/R-HSA-174757.md	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	218	R-HSA-2395768	LPL hydrolyses TGs from mature CMs	yes	reactome/R-HSA-2395768.md	LPL hydrolyses TGs from mature CMs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	219	R-HSA-2395784	Nascent CMs transform into mature CMs	yes	reactome/R-HSA-2395784.md	Nascent CMs transform into mature CMs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	220	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	221	R-HSA-2423785	CR:atREs binds apoE and HSPG	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	222	R-HSA-2507854	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	yes	reactome/R-HSA-2507854.md	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	223	R-HSA-266303	Spherical HDL binds C and E apolipoproteins	yes	reactome/R-HSA-266303.md	Spherical HDL binds C and E apolipoproteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	224	R-HSA-8869590	The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK	yes	reactome/R-HSA-8869590.md	The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	225	R-HSA-9031512	Expression of APOE regulated by NR1H2 or NR1H3	yes	reactome/R-HSA-9031512.md	Expression of APOE regulated by NR1H2 or NR1H3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	226	R-HSA-9612243	APOE gene transcription is stimulated by ERBB4s80	yes	reactome/R-HSA-9612243.md	APOE gene transcription is stimulated by ERBB4s80	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	APOE is appropriately localized to extracellular region as a secreted apolipoprotein associated with plasma and tissue lipoprotein particles.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	227	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005769	early endosome	TAS	located_in	CC	false		KEEP_AS_NON_CORE	early endosome is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	228	R-HSA-2404140	NREH hydrolyses atREs to atROL and FAs	yes	reactome/R-HSA-2404140.md	NREH hydrolyses atREs to atROL and FAs	Homo sapiens	GO:0005769	early endosome	TAS	located_in	CC	false		KEEP_AS_NON_CORE	early endosome is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	229	R-HSA-2429643	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005769	early endosome	TAS	located_in	CC	false		KEEP_AS_NON_CORE	early endosome is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	230	R-HSA-174657	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex	yes	reactome/R-HSA-174657.md	chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	plasma membrane is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	231	R-HSA-174706	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)	yes	reactome/R-HSA-174706.md	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	plasma membrane is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	232	R-HSA-174706	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)	yes	reactome/R-HSA-174706.md	chylomicron remnant:apoE:LDLR complex [plasma membrane] => chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	clathrin-coated endocytic vesicle membrane is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOE	genes/human/APOE/APOE-ai-review.yaml	APOE	P02649	NCBITaxon:9606	Homo sapiens	233	R-HSA-2507854	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	yes	reactome/R-HSA-2507854.md	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	Homo sapiens	GO:0071682	endocytic vesicle lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endocytic vesicle lumen is retained as APOE-associated contextual biology, not as the core apolipoprotein activity.
human	APOL1	genes/human/APOL1/APOL1-ai-review.yaml	APOL1	O14791	NCBITaxon:9606	Homo sapiens	7	R-HSA-2168889	Haptoglobin-related Protein binds Hemoglobin	yes	reactome/R-HSA-2168889.md	Haptoglobin-related Protein binds Hemoglobin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The Reactome TLF-1 complex contains extracellular APOL1.
human	APOL1	genes/human/APOL1/APOL1-ai-review.yaml	APOL1	O14791	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		UNDECIDED	The APOL1-specific ER-lumen entity is not exposed in this event summary.
human	APOOL	genes/human/APOOL/APOOL-ai-review.yaml	APOOL	Q6UXV4	NCBITaxon:9606	Homo sapiens	5	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	A name-era artefact. APOOL is not secreted; the row is a projection of a Reactome platelet pathway membership that itself rests on a 2004 bulk releasate proteomics screen.
human	APOOL	genes/human/APOOL/APOOL-ai-review.yaml	APOOL	Q6UXV4	NCBITaxon:9606	Homo sapiens	16	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		REMOVE	The second half of the same Reactome platelet projection, and the more specific of the two false locations. APOOL is not a platelet granule cargo protein.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	188	R-HSA-9839072	HTRA2 degrades APP (Amyloid-beta precursor protein)	yes	reactome/R-HSA-9839072.md	HTRA2 degrades APP (Amyloid-beta precursor protein)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	189	R-HSA-9839072	HTRA2 degrades APP (Amyloid-beta precursor protein)	yes	reactome/R-HSA-9839072.md	HTRA2 degrades APP (Amyloid-beta precursor protein)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	271	R-HSA-9617595	SGTA binds mislocalized membrane protein	yes	reactome/R-HSA-9617595.md	SGTA binds mislocalized membrane protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	290	R-HSA-9010034	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	yes	reactome/R-HSA-9010034.md	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	291	R-HSA-9010034	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	yes	reactome/R-HSA-9010034.md	ADAM10:Zn2+:TSPANs cleaves APP(18-770)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	292	R-HSA-9010091	APP translocates from plasma membrane to endosome lumen	yes	reactome/R-HSA-9010091.md	APP translocates from plasma membrane to endosome lumen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	293	R-HSA-5692495	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	yes	reactome/R-HSA-5692495.md	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	294	R-HSA-9010096	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	yes	reactome/R-HSA-9010096.md	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	332	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	335	R-HSA-8871506	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	yes	reactome/R-HSA-8871506.md	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	343	R-HSA-6783332	APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region	yes	reactome/R-HSA-6783332.md	APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	358	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	359	R-HSA-1296421	NLRP3 oligomerizes via NACHT domains	yes	reactome/R-HSA-1296421.md	NLRP3 oligomerizes via NACHT domains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	360	R-HSA-844440	NLRP3 activation by elicitor proteins	yes	reactome/R-HSA-844440.md	NLRP3 activation by elicitor proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	361	R-HSA-844610	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction	yes	reactome/R-HSA-844610.md	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	362	R-HSA-844612	PYCARD recruits procaspase-1 via CARD	yes	reactome/R-HSA-844612.md	PYCARD recruits procaspase-1 via CARD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	363	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	364	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	365	R-HSA-8871494	SORL1 binds APP(18-770)	yes	reactome/R-HSA-8871494.md	SORL1 binds APP(18-770)	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	366	R-HSA-8871506	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	yes	reactome/R-HSA-8871506.md	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	367	R-HSA-9010091	APP translocates from plasma membrane to endosome lumen	yes	reactome/R-HSA-9010091.md	APP translocates from plasma membrane to endosome lumen	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	368	R-HSA-5229111	AP4 transports APP from trans-Golgi network to endosome lumen	yes	reactome/R-HSA-5229111.md	AP4 transports APP from trans-Golgi network to endosome lumen	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	369	R-HSA-5229132	AP4 binds APP	yes	reactome/R-HSA-5229132.md	AP4 binds APP	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	370	R-HSA-2467665	AGRN binds Beta amyloid fibril via GAG chains	yes	reactome/R-HSA-2467665.md	AGRN binds Beta amyloid fibril via GAG chains	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	371	R-HSA-6783332	APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region	yes	reactome/R-HSA-6783332.md	APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	372	R-HSA-879411	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor	yes	reactome/R-HSA-879411.md	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	373	R-HSA-976734	Amyloid fibrils have additional components	yes	reactome/R-HSA-976734.md	Amyloid fibrils have additional components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	374	R-HSA-977136	Amyloid precursor proteins form ordered fibrils	yes	reactome/R-HSA-977136.md	Amyloid precursor proteins form ordered fibrils	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	375	R-NUL-997411	AGER binds rat ERK1/2	yes	reactome/R-NUL-997411.md	AGER binds rat ERK1/2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	376	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	377	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	378	R-HSA-391913	FPR2 binds FPR2 ligands	yes	reactome/R-HSA-391913.md	FPR2 binds FPR2 ligands	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	379	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	380	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	381	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	382	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APP	genes/human/APP/APP-ai-review.yaml	APP	P05067	NCBITaxon:9606	Homo sapiens	383	R-HSA-8870710	APP gene expression	yes	reactome/R-HSA-8870710.md	APP gene expression	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway database.
human	APRT	genes/human/APRT/APRT-ai-review.yaml	APRT	P07741	NCBITaxon:9606	Homo sapiens	20	R-HSA-9734193	Defective APRT does not convert adenine to AMP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (Defective APRT does not convert adenine to AMP) placing APRT in the cytosol, the site of the salvage reaction.
human	APRT	genes/human/APRT/APRT-ai-review.yaml	APRT	P07741	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome annotation derived from the neutrophil-degranulation pathway (Exocytosis of secretory granule lumen proteins). APRT is detected in neutrophil granule proteomes but this is not its site of catalytic function.
human	APRT	genes/human/APRT/APRT-ai-review.yaml	APRT	P07741	NCBITaxon:9606	Homo sapiens	22	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome annotation from the neutrophil-degranulation pathway. Reflects detection of APRT in neutrophil granule preparations, not a bona fide functional localization of this cytosolic enzyme.
human	APRT	genes/human/APRT/APRT-ai-review.yaml	APRT	P07741	NCBITaxon:9606	Homo sapiens	26	R-HSA-74213	APRT catalyzes the conversion of adenine to AMP	yes	reactome/R-HSA-74213.md	APRT catalyzes the conversion of adenine to AMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (APRT catalyzes the conversion of adenine to AMP) placing the reaction in the cytosol, the correct functional location.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	149	R-HSA-376419	Formation of NR-MED1 Coactivator Complex	yes	reactome/R-HSA-376419.md	Formation of NR-MED1 Coactivator Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	150	R-HSA-382096	Formation of NR-NCOR Corepressor Complex	yes	reactome/R-HSA-382096.md	Formation of NR-NCOR Corepressor Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	151	R-HSA-4090390	PIAS1,2-1 SUMOylates AR with SUMO1	yes	reactome/R-HSA-4090390.md	PIAS1,2-1 SUMOylates AR with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	152	R-HSA-5618080	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	153	R-HSA-5618093	ATP hydrolysis by HSP90	yes	reactome/R-HSA-5618093.md	ATP hydrolysis by HSP90	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	154	R-HSA-5625738	p-T774-PKN1:AR:Androgen complex translocates to the nucleus	yes	reactome/R-HSA-5625738.md	p-T774-PKN1:AR:Androgen complex translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	155	R-HSA-5625745	PKN1 stimulates association of AR with NCOA2	yes	reactome/R-HSA-5625745.md	PKN1 stimulates association of AR with NCOA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	156	R-HSA-5625774	PKN1:AR complex binds promoters of KLK2 and KLK3 genes	yes	reactome/R-HSA-5625774.md	PKN1:AR complex binds promoters of KLK2 and KLK3 genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	157	R-HSA-5625784	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625784.md	PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	158	R-HSA-5625796	Demethylase KDM4C binds KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625796.md	Demethylase KDM4C binds KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	159	R-HSA-5625797	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625797.md	KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	160	R-HSA-5625848	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625848.md	KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	161	R-HSA-5625849	Demethylase KDM1A binds KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625849.md	Demethylase KDM1A binds KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	162	R-HSA-5625870	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters	yes	reactome/R-HSA-5625870.md	KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	163	R-HSA-5696605	USP12, USP26 deubiquitinate AR	yes	reactome/R-HSA-5696605.md	USP12, USP26 deubiquitinate AR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	164	R-HSA-8877902	Activated AR binds RUNX2	yes	reactome/R-HSA-8877902.md	Activated AR binds RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	172	R-HSA-5618080	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	173	R-HSA-5625717	Phosphorylated PKN1 binds androgen receptor (AR)	yes	reactome/R-HSA-5625717.md	Phosphorylated PKN1 binds androgen receptor (AR)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	174	R-HSA-5625738	p-T774-PKN1:AR:Androgen complex translocates to the nucleus	yes	reactome/R-HSA-5625738.md	p-T774-PKN1:AR:Androgen complex translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	175	R-HSA-9705925	Androgens binds AR (in the HSP90 chaperone complex)	yes	reactome/R-HSA-9705925.md	Androgens binds AR (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	176	R-HSA-9705926	AR binds AR agonists	yes	reactome/R-HSA-9705926.md	AR binds AR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	AR	genes/human/AR/AR-ai-review.yaml	AR	P10275	NCBITaxon:9606	Homo sapiens	177	R-HSA-9706837	AR binds AR antagonists	yes	reactome/R-HSA-9706837.md	AR binds AR antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol — accept.
human	ARC	genes/human/ARC/ARC-ai-review.yaml	ARC	Q7LC44	NCBITaxon:9606	Homo sapiens	12	R-HSA-9031624	ARC gene expression	yes	reactome/R-HSA-9031624.md	ARC gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Compartment assignment attached to the Reactome 'ARC gene expression' pathway, which places the newly translated ARC protein in the cytosol. Uncontroversial - Arc is translated on cytosolic and dendritic ribosomes and has no signal peptide or transmembrane segment - but it is a pathway-diagram statement rather than an observation.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	25	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs"". ARCN1 associates with ER membrane during retrograde COPI vesicle targeting and fusion."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	26	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COPI vesicle uncoating at the ER"". ARCN1 is present on COPI vesicles that undergo uncoating at the ER membrane."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	27	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Vesicle is tethered through binding GOLGA2 GORASP1, GOLGB1 and the COG complex"". Documents ARCN1 on vesicles tethering to Golgi."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	28	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COPI vesicle uncoating"". Documents ARCN1 during vesicle uncoating at Golgi membranes."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	29	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""cis-Golgi t-SNAREs bind YKT6 on tethered vesicle"". Documents ARCN1 on vesicles engaging with Golgi SNARE machinery."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	30	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""ARFGAPs stimulate ARF GTPase activity"". ARCN1 is on transport vesicles during ARF-GAP mediated vesicle scission."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	31	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""ERGIC-to-Golgi vesicles bind dynein dynactin"". ARCN1 on transport vesicles engaging motor proteins."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	32	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway documenting ARCN1 on transport vesicles during tethering.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	33	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""ARFGAPs stimulate ARF GTPase activity at the Golgi membrane"". ARCN1 on vesicles during Golgi-based budding."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	34	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway documenting ARCN1 on retrograde transport vesicles targeting the ER.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	35	R-HSA-6811426	Retrograde COPI vesicles bind kinesin and microtubules	yes	reactome/R-HSA-6811426.md	Retrograde COPI vesicles bind kinesin and microtubules	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Retrograde COPI vesicles bind kinesin and microtubules"". ARCN1 on vesicles engaging motor proteins."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	38	R-HSA-6807872	Active ARF recruits coatomer	yes	reactome/R-HSA-6807872.md	Active ARF recruits coatomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Active ARF recruits coatomer"". ARCN1 exists in cytosol as part of the soluble coatomer complex pool before membrane recruitment."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	39	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway documenting ARCN1 in cytosol during coatomer complex formation and cargo binding.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome documenting ARCN1 in cytosol during vesicle budding and ARF-GAP activity.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	41	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COPI vesicle uncoating"". ARCN1 returns to cytosol after vesicle coat disassembly."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	42	R-HSA-6811412	Active ARF recruits coatomer to the Golgi	yes	reactome/R-HSA-6811412.md	Active ARF recruits coatomer to the Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Active ARF recruits coatomer to the Golgi"". Documents cytosolic coatomer containing ARCN1 before Golgi recruitment."
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	43	R-HSA-6811417	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	yes	reactome/R-HSA-6811417.md	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome documenting ARCN1 in cytosol during Golgi-based COPI vesicle formation.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	44	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome documenting ARCN1 in cytosol during ARF-GAP mediated vesicle scission at Golgi.
human	ARCN1	genes/human/ARCN1/ARCN1-ai-review.yaml	ARCN1	P48444	NCBITaxon:9606	Homo sapiens	45	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COPI vesicle uncoating at the ER"". ARCN1 returns to cytosol after ER-targeted vesicles undergo coat disassembly."
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	36	R-HSA-8847883	CYTH proteins stimulate ARF1 GTPase activity	yes	reactome/R-HSA-8847883.md	CYTH proteins stimulate ARF1 GTPase activity	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		ACCEPT	ARF1 is a canonical small GTPase that binds guanine nucleotide and hydrolyzes GTP as part of its membrane-trafficking cycle.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	53	R-HSA-1675883	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane	yes	reactome/R-HSA-1675883.md	PI is phosphorylated to PI4P by PI4KB at the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	54	R-HSA-1676152	PI4KB binds to ARF1/3:GTP at the Golgi membrane	yes	reactome/R-HSA-1676152.md	PI4KB binds to ARF1/3:GTP at the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	55	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	56	R-HSA-350769	trans-Golgi Network Coat Activation	yes	reactome/R-HSA-350769.md	trans-Golgi Network Coat Activation	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	57	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	58	R-HSA-421833	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	yes	reactome/R-HSA-421833.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	59	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	60	R-HSA-432712	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	yes	reactome/R-HSA-432712.md	Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	61	R-HSA-8847875	ARF1:GTP binds Golgin TRIP11	yes	reactome/R-HSA-8847875.md	ARF1:GTP binds Golgin TRIP11	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	62	R-HSA-8847880	CYTH proteins bind ARF1:GTP	yes	reactome/R-HSA-8847880.md	CYTH proteins bind ARF1:GTP	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	63	R-HSA-8847883	CYTH proteins stimulate ARF1 GTPase activity	yes	reactome/R-HSA-8847883.md	CYTH proteins stimulate ARF1 GTPase activity	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	64	R-HSA-8870499	PLEKHA3,8 bind PI4P, ARF1	yes	reactome/R-HSA-8870499.md	PLEKHA3,8 bind PI4P, ARF1	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	65	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	66	R-HSA-9845055	PLEKHA8 catalyzes transport of GlcCer to plasma membrane	yes	reactome/R-HSA-9845055.md	PLEKHA8 catalyzes transport of GlcCer to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization is central to ARF1 function in coat recruitment and Golgi/TGN trafficking.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	67	R-HSA-200879	Formation of a Nef:ARF1:CD4 complex	yes	reactome/R-HSA-200879.md	Formation of a Nef:ARF1:CD4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	68	R-HSA-350769	trans-Golgi Network Coat Activation	yes	reactome/R-HSA-350769.md	trans-Golgi Network Coat Activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	69	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	70	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	71	R-HSA-8950173	Expression of ADP-ribosylation factor 1	yes	reactome/R-HSA-8950173.md	Expression of ADP-ribosylation factor 1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	72	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is consistent with the soluble GDP-bound pool of ARF1 between membrane-recruitment cycles.
human	ARF1	genes/human/ARF1/ARF1-ai-review.yaml	ARF1	P84077	NCBITaxon:9606	Homo sapiens	75	R-HSA-6811434	COPI-dependent Golgi-to-ER retrograde traffic	yes	reactome/R-HSA-6811434.md	COPI-dependent Golgi-to-ER retrograde traffic	Homo sapiens	GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	TAS	involved_in	BP	false		NEW	PN projection and Reactome support adding the specific Golgi-to-ER retrograde transport process for ARF1.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	20	R-HSA-9956512	ARG1 variants don't synthesize urea and ornithine	yes	reactome/R-HSA-9956512.md	ARG1 variants don't synthesize urea and ornithine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation (ARG1 variant reaction) placing ARG1 in the cytosol.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation (exocytosis of specific granule lumen proteins) placing ARG1 in the extracellular region upon neutrophil degranulation.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation (exocytosis of azurophil granule lumen proteins) placing ARG1 in the extracellular region upon neutrophil degranulation.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	31	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing ARG1 in the azurophil granule lumen of neutrophils.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	32	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing ARG1 in the specific granule lumen of neutrophils.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	34	R-HSA-70569	arginine + H2O => ornithine + urea [ARG1]	yes	reactome/R-HSA-70569.md	arginine + H2O => ornithine + urea [ARG1]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation (arginine + H2O => ornithine + urea reaction) placing ARG1 in the cytosol.
human	ARG1	genes/human/ARG1/ARG1-ai-review.yaml	ARG1	P05089	NCBITaxon:9606	Homo sapiens	35	R-HSA-9959871	ARG1 gene expression	yes	reactome/R-HSA-9959871.md	ARG1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation (ARG1 gene expression) associated with cytosolic localization.
human	ARHGAP11B	genes/human/ARHGAP11B/ARHGAP11B-ai-review.yaml	ARHGAP11B	Q3KRB8	NCBITaxon:9606	Homo sapiens	3	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		REMOVE	Reactome asserts, by TAS, the exact molecular function that two independent IDA annotations on this same gene explicitly negate. GOA therefore ships a flat contradiction inside one gene's record, and the positive side carries the weaker evidence code.
human	ARHGAP11B	genes/human/ARHGAP11B/ARHGAP11B-ai-review.yaml	ARHGAP11B	Q3KRB8	NCBITaxon:9606	Homo sapiens	8	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	A cytosol annotation produced by the same Reactome reaction as the contradicted GAP-activity row, and by the same mechanism: the compartment is the reaction's, not a measurement of where ARHGAP11B is.
human	ARHGAP11B	genes/human/ARHGAP11B/ARHGAP11B-ai-review.yaml	ARHGAP11B	Q3KRB8	NCBITaxon:9606	Homo sapiens	17	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		REMOVE	Pathway-membership annotation placing ARHGAP11B in the RHO GTPase cycle. The gene has no measured role in small GTPase signalling, and a NOT annotation on the closely related GO:0043547 points the other way.
human	ARHGAP21	genes/human/ARHGAP21/ARHGAP21-ai-review.yaml	ARHGAP21	Q5T5U3	NCBITaxon:9606	Homo sapiens	4	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	GAP activity, asserted by Reactome from the reaction 'RHOA GAPs stimulate RHOA GTPase activity'.
human	ARHGAP21	genes/human/ARHGAP21/ARHGAP21-ai-review.yaml	ARHGAP21	Q5T5U3	NCBITaxon:9606	Homo sapiens	31	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, asserted by Reactome as the compartment of the 'RHOA GAPs stimulate RHOA GTPase activity' reaction.
human	ARHGAP21	genes/human/ARHGAP21/ARHGAP21-ai-review.yaml	ARHGAP21	Q5T5U3	NCBITaxon:9606	Homo sapiens	41	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		ACCEPT	Regulation of small GTPase mediated signal transduction, asserted by Reactome from the RHO GTPase cycle.
human	ARHGAP23	genes/human/ARHGAP23/ARHGAP23-ai-review.yaml	ARHGAP23	Q9P227	NCBITaxon:9606	Homo sapiens	2	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	"A set-level Reactome projection that happens to be correct here. The reaction's catalyst is the defined entity ""GTPase activator activity of RHOA GAPs"", so every member receives this term; ARHGAP23's membership is sourced in Reactome's own summary to the FRET specificity screen, which scores it significantly active on RhoA."
human	ARHGAP23	genes/human/ARHGAP23/ARHGAP23-ai-review.yaml	ARHGAP23	Q9P227	NCBITaxon:9606	Homo sapiens	3	R-HSA-9013144	RAC1 GAPs stimulate RAC1 GTPase activity	yes	reactome/R-HSA-9013144.md	RAC1 GAPs stimulate RAC1 GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	The RAC1 counterpart of the previous row, from the equivalent RAC1 GAP catalyst set. Reactome sources ARHGAP23's membership to the Rac FRET biosensor study PMID:28114311 and to the family-wide screen, both of which report Rac1-directed activity.
human	ARHGAP23	genes/human/ARHGAP23/ARHGAP23-ai-review.yaml	ARHGAP23	Q9P227	NCBITaxon:9606	Homo sapiens	4	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The compartment attached to the RHOA GAP reaction, projected onto every member. A cytosolic pool of ARHGAP23 is real and is functionally implicated in the keratinocyte work, but it is not where the protein does most of its reported work, and this row is not evidence of localization in its own right.
human	ARHGAP23	genes/human/ARHGAP23/ARHGAP23-ai-review.yaml	ARHGAP23	Q9P227	NCBITaxon:9606	Homo sapiens	5	R-HSA-9013144	RAC1 GAPs stimulate RAC1 GTPase activity	yes	reactome/R-HSA-9013144.md	RAC1 GAPs stimulate RAC1 GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	A duplicate of the preceding row, arising because ARHGAP23 is a member of two Reactome catalyst sets that are both annotated to the cytosol. It adds no independent information.
human	ARHGAP23	genes/human/ARHGAP23/ARHGAP23-ai-review.yaml	ARHGAP23	Q9P227	NCBITaxon:9606	Homo sapiens	7	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		MODIFY	True, correctly placed on the regulation branch, and too general. It is a pathway-membership projection: every participant in Reactome's RHO GTPase cycle receives this term, so it records that ARHGAP23 is in the cycle rather than what it does there.
human	ARHGAP29	genes/human/ARHGAP29/ARHGAP29-ai-review.yaml	ARHGAP29	Q52LW3	NCBITaxon:9606	Homo sapiens	3	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	ARHGAP29 contributes GAP activity to the RHOA inactivation reaction.
human	ARHGAP29	genes/human/ARHGAP29/ARHGAP29-ai-review.yaml	ARHGAP29	Q52LW3	NCBITaxon:9606	Homo sapiens	7	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated RHOA-GAP event includes cytosolic ARHGAP29.
human	ARHGAP29	genes/human/ARHGAP29/ARHGAP29-ai-review.yaml	ARHGAP29	Q52LW3	NCBITaxon:9606	Homo sapiens	13	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		ACCEPT	ARHGAP29 participates in regulation of the Rho GDP/GTP cycle.
human	ARHGAP4	genes/human/ARHGAP4/ARHGAP4-ai-review.yaml	ARHGAP4	P98171	NCBITaxon:9606	Homo sapiens	4	R-HSA-9013144	RAC1 GAPs stimulate RAC1 GTPase activity	yes	reactome/R-HSA-9013144.md	RAC1 GAPs stimulate RAC1 GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	"Reactome places ARHGAP4 in the reaction ""RAC1 GAPs stimulate RAC1 GTPase activity"", which is a substrate-specific claim that the GO term itself cannot carry."
human	ARHGAP4	genes/human/ARHGAP4/ARHGAP4-ai-review.yaml	ARHGAP4	P98171	NCBITaxon:9606	Homo sapiens	11	R-HSA-9013144	RAC1 GAPs stimulate RAC1 GTPase activity	yes	reactome/R-HSA-9013144.md	RAC1 GAPs stimulate RAC1 GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The compartment Reactome assigns to the RAC1-GAP reaction that ARHGAP4 participates in.
human	ARHGAP4	genes/human/ARHGAP4/ARHGAP4-ai-review.yaml	ARHGAP4	P98171	NCBITaxon:9606	Homo sapiens	22	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		ACCEPT	The Reactome placement of ARHGAP4 in the RHO GTPase cycle.
human	ARHGAP6	genes/human/ARHGAP6/ARHGAP6-ai-review.yaml	ARHGAP6	O43182	NCBITaxon:9606	Homo sapiens	3	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	Reactome's RHOA-GAP event, and the better-grounded of its two GAP assertions for this protein.
human	ARHGAP6	genes/human/ARHGAP6/ARHGAP6-ai-review.yaml	ARHGAP6	O43182	NCBITaxon:9606	Homo sapiens	4	R-HSA-9018806	RAC3 GAPs stimulate RAC3 GTPase activity	yes	reactome/R-HSA-9018806.md	RAC3 GAPs stimulate RAC3 GTPase activity	Homo sapiens	GO:0005096	GTPase activator activity	TAS	enables	MF	false		ACCEPT	Same term, but reached through a RAC3-GAP claim that rests on a co-immunoprecipitation.
human	ARHGAP6	genes/human/ARHGAP6/ARHGAP6-ai-review.yaml	ARHGAP6	O43182	NCBITaxon:9606	Homo sapiens	30	R-HSA-8981637	RHOA GAPs stimulate RHOA GTPase activity	yes	reactome/R-HSA-8981637.md	RHOA GAPs stimulate RHOA GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation; true but not where the informative biology is.
human	ARHGAP6	genes/human/ARHGAP6/ARHGAP6-ai-review.yaml	ARHGAP6	O43182	NCBITaxon:9606	Homo sapiens	31	R-HSA-9018806	RAC3 GAPs stimulate RAC3 GTPase activity	yes	reactome/R-HSA-9018806.md	RAC3 GAPs stimulate RAC3 GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localisation; true but not where the informative biology is.
human	ARHGAP6	genes/human/ARHGAP6/ARHGAP6-ai-review.yaml	ARHGAP6	O43182	NCBITaxon:9606	Homo sapiens	41	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Regulation of small GTPase mediated signal transduction; true, and strictly more general than terms already held.
human	ARHGEF15	genes/human/ARHGEF15/ARHGEF15-ai-review.yaml	ARHGEF15	O94989	NCBITaxon:9606	Homo sapiens	6	R-HSA-8980691	RHOA GEFs activate RHOA	yes	reactome/R-HSA-8980691.md	RHOA GEFs activate RHOA	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	Reactome places ARHGEF15 in its confirmed list of RHOA GEFs. Consistent with every other line of evidence, and the citation behind it is a family-wide specificity screen.
human	ARHGEF15	genes/human/ARHGEF15/ARHGEF15-ai-review.yaml	ARHGEF15	O94989	NCBITaxon:9606	Homo sapiens	7	R-HSA-9013159	CDC42 GEFs activate CDC42	yes	reactome/R-HSA-9013159.md	CDC42 GEFs activate CDC42	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	Reactome places ARHGEF15 in its confirmed list of CDC42 GEFs as well. This is the only point in the entire GO record where CDC42 is named for this gene, and it is supported by three independent measurements.
human	ARHGEF15	genes/human/ARHGEF15/ARHGEF15-ai-review.yaml	ARHGEF15	O94989	NCBITaxon:9606	Homo sapiens	17	R-HSA-8980691	RHOA GEFs activate RHOA	yes	reactome/R-HSA-8980691.md	RHOA GEFs activate RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome's compartment assignment for the RHOA GEF reaction. A modelling convention rather than a measurement.
human	ARHGEF15	genes/human/ARHGEF15/ARHGEF15-ai-review.yaml	ARHGEF15	O94989	NCBITaxon:9606	Homo sapiens	18	R-HSA-9013159	CDC42 GEFs activate CDC42	yes	reactome/R-HSA-9013159.md	CDC42 GEFs activate CDC42	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The same compartment assignment from the CDC42 GEF reaction.
human	ARHGEF15	genes/human/ARHGEF15/ARHGEF15-ai-review.yaml	ARHGEF15	O94989	NCBITaxon:9606	Homo sapiens	25	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome's RHO GTPase cycle membership. True, and subsumed by the more specific GO:0035025 row that the human experimental evidence supports.
human	ARHGEF16	genes/human/ARHGEF16/ARHGEF16-ai-review.yaml	ARHGEF16	Q5VV41	NCBITaxon:9606	Homo sapiens	64	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, asserted by Reactome reaction R-HSA-205039.
human	ARHGEF16	genes/human/ARHGEF16/ARHGEF16-ai-review.yaml	ARHGEF16	Q5VV41	NCBITaxon:9606	Homo sapiens	65	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, asserted by Reactome reaction R-HSA-419166.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	8	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of two Reactome cytosol rows. This one comes from the reaction p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor, in which ARHGEF18 is a member of a generic GEFs catalyst set rather than a named participant.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	9	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The second Reactome cytosol row, from the reaction GEFs activate RhoA,B,C. ARHGEF18 is again a member of a generic GEFs catalyst set, but here the reaction substrate matches the protein's established activity.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	23	R-HSA-2160931	Disassembly of tight junctions	yes	reactome/R-HSA-2160931.md	Disassembly of tight junctions	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows. ARHGEF18 is a component of Reactome's Tight Junction Complex entity, and every reaction that consumes or produces that complex assigns the cell-junction compartment to all of its participants. This reaction is Disassembly of tight junctions.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	24	R-HSA-2160932	SMURF1 binds phosphorylated PARD6A	yes	reactome/R-HSA-2160932.md	SMURF1 binds phosphorylated PARD6A	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows, from the reaction SMURF1 binds phosphorylated PARD6A, whose inputs and outputs contain the Tight Junction Complex entity of which ARHGEF18 is a member.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	25	R-HSA-2160935	SMURF1 ubiquitinates RHOA	yes	reactome/R-HSA-2160935.md	SMURF1 ubiquitinates RHOA	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows, from the reaction SMURF1 ubiquitinates RHOA within the tight-junction-associated complex.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	26	R-NUL-2161147	TGFBR1 is recruited to tight junction by binding Pard6a	yes	reactome/R-NUL-2161147.md	TGFBR1 is recruited to tight junction by binding Pard6a	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows. The R-NUL prefix marks an inferred, non-human-specific event, here TGFBR1 is recruited to tight junction by binding Pard6a.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	27	R-NUL-2161160	TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation	yes	reactome/R-NUL-2161160.md	TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows, from the inferred event TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation.
human	ARHGEF18	genes/human/ARHGEF18/ARHGEF18-ai-review.yaml	ARHGEF18	Q6ZSZ5	NCBITaxon:9606	Homo sapiens	28	R-NUL-2161165	TGFBR2 phosphorylates Pard6a	yes	reactome/R-NUL-2161165.md	TGFBR2 phosphorylates Pard6a	Homo sapiens	GO:0030054	cell junction	TAS	located_in	CC	false		KEEP_AS_NON_CORE	One of six identical Reactome cell-junction rows, from the inferred event TGFBR2 phosphorylates Pard6a.
human	ARHGEF19	genes/human/ARHGEF19/ARHGEF19-ai-review.yaml	ARHGEF19	Q8IW93	NCBITaxon:9606	Homo sapiens	3	R-HSA-8980691	RHOA GEFs activate RHOA	yes	reactome/R-HSA-8980691.md	RHOA GEFs activate RHOA	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	Correct. Reactome places ARHGEF19 in its RHOA GEF set on the strength of the 2004 characterisation paper, which is the same paper GO itself never annotated.
human	ARHGEF19	genes/human/ARHGEF19/ARHGEF19-ai-review.yaml	ARHGEF19	Q8IW93	NCBITaxon:9606	Homo sapiens	6	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	The compartment is not false, but the route by which ARHGEF19 acquired it is. This Reactome reaction produces RAC1-GTP, and human WGEF does not activate Rac1.
human	ARHGEF19	genes/human/ARHGEF19/ARHGEF19-ai-review.yaml	ARHGEF19	Q8IW93	NCBITaxon:9606	Homo sapiens	7	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome compartment convention for a RhoA-GEF reaction, not a localisation experiment on this protein. Keep, but not as a core location.
human	ARHGEF19	genes/human/ARHGEF19/ARHGEF19-ai-review.yaml	ARHGEF19	Q8IW93	NCBITaxon:9606	Homo sapiens	8	R-HSA-8980691	RHOA GEFs activate RHOA	yes	reactome/R-HSA-8980691.md	RHOA GEFs activate RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Same compartment convention as the R-HSA-419166 row, attached to the RHOA-GEF reaction. Keep as non-core.
human	ARHGEF19	genes/human/ARHGEF19/ARHGEF19-ai-review.yaml	ARHGEF19	Q8IW93	NCBITaxon:9606	Homo sapiens	12	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		MODIFY	Right idea, needlessly generic. Both the Reactome source and the experimental data are Rho-specific and directional, so a Rho-specific positive-regulation term is available and better.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	3	R-HSA-9013159	CDC42 GEFs activate CDC42	yes	reactome/R-HSA-9013159.md	CDC42 GEFs activate CDC42	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	The CDC42 GEF event explicitly identifies ARHGEF9.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	18	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Independent target evidence supports the cytosolic pool; the event graph remains uninspected.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	19	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The compartment is supported independently of the broad Rho-family event.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	20	R-HSA-9013159	CDC42 GEFs activate CDC42	yes	reactome/R-HSA-9013159.md	CDC42 GEFs activate CDC42	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The target-specific CDC42 event agrees with independent cytosolic localization.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	21	R-HSA-975340	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol	yes	reactome/R-HSA-975340.md	GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization does not imply GABA-channel activity.
human	ARHGEF9	genes/human/ARHGEF9/ARHGEF9-ai-review.yaml	ARHGEF9	O43307	NCBITaxon:9606	Homo sapiens	25	R-HSA-9012999	RHO GTPase cycle	yes	reactome/R-HSA-9012999.md	RHO GTPase cycle	Homo sapiens	GO:0051056	regulation of small GTPase mediated signal transduction	TAS	involved_in	BP	false		ACCEPT	The established exchange-factor role fits the GDP/GTP-cycle process.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	33	R-HSA-9766293	ARID1A binds CDH1 gene promoter	yes	reactome/R-HSA-9766293.md	ARID1A binds CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	34	R-HSA-9825847	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	yes	reactome/R-HSA-9825847.md	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is supported by the integrated human evidence.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	35	R-HSA-9932437	ARID1 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1	yes	reactome/R-HSA-9932437.md	ARID1 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	36	R-HSA-9932836	DPF1,2,3 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1	yes	reactome/R-HSA-9932836.md	DPF1,2,3 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	37	R-HSA-9933238	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	yes	reactome/R-HSA-9933238.md	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	38	R-HSA-9934021	Formation of neuronal progenitor BAF (npBAF)	yes	reactome/R-HSA-9934021.md	Formation of neuronal progenitor BAF (npBAF)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	39	R-HSA-9934022	DPF2, PHF10 bind SMARCC1:SMARCC2 dimer:SMARD1:ARID1A	yes	reactome/R-HSA-9934022.md	DPF2, PHF10 bind SMARCC1:SMARCC2 dimer:SMARD1:ARID1A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	40	R-HSA-9934024	SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10	yes	reactome/R-HSA-9934024.md	SMARCA4, BCL11A,B-containing ATPase module binds SMARCC1:SMACC2 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1A:DPF2, PHF10	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1A	genes/human/ARID1A/ARID1A-ai-review.yaml	ARID1A	O14497	NCBITaxon:9606	Homo sapiens	41	R-HSA-9934028	ARID1A binds SMARCC1:SMARCC2 dimer:SMARCD1:SMARCE1:SMARCB1	yes	reactome/R-HSA-9934028.md	ARID1A binds SMARCC1:SMARCC2 dimer:SMARCD1:SMARCE1:SMARCB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm — accept.
human	ARID1B	genes/human/ARID1B/ARID1B-ai-review.yaml	ARID1B	Q8NFD5	NCBITaxon:9606	Homo sapiens	19	R-HSA-9825847	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	yes	reactome/R-HSA-9825847.md	MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ARID1B has an independently supported nucleoplasmic transcriptional pool.
human	ARID1B	genes/human/ARID1B/ARID1B-ai-review.yaml	ARID1B	Q8NFD5	NCBITaxon:9606	Homo sapiens	20	R-HSA-9932437	ARID1 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1	yes	reactome/R-HSA-9932437.md	ARID1 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ARID1B-containing cBAF assembly is consistent with nucleoplasmic localization.
human	ARID1B	genes/human/ARID1B/ARID1B-ai-review.yaml	ARID1B	Q8NFD5	NCBITaxon:9606	Homo sapiens	21	R-HSA-9932836	DPF1,2,3 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1	yes	reactome/R-HSA-9932836.md	DPF1,2,3 binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DPF recruitment occurs within an ARID-containing nuclear assembly.
human	ARID1B	genes/human/ARID1B/ARID1B-ai-review.yaml	ARID1B	Q8NFD5	NCBITaxon:9606	Homo sapiens	22	R-HSA-9933238	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	yes	reactome/R-HSA-9933238.md	SS18-containing ATPase complex binds SMARCC1 dimer:SMARCD1:SMARCE1:SMARCB1:ARID1:DPF1,2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The ARID-containing core joins an ATPase module in the nuclear pool.
human	ARID1B	genes/human/ARID1B/ARID1B-ai-review.yaml	ARID1B	Q8NFD5	NCBITaxon:9606	Homo sapiens	23	R-HSA-9934021	Formation of neuronal progenitor BAF (npBAF)	yes	reactome/R-HSA-9934021.md	Formation of neuronal progenitor BAF (npBAF)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Curated npBAF assembly agrees with independently supported human nucleoplasm.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	22	R-HSA-9833482	PKR-mediated signaling	yes	reactome/R-HSA-9833482.md	PKR-mediated signaling	Homo sapiens	GO:0039585	PKR/eIFalpha signaling	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	PKR/eIFalpha signaling is a pathway-level consequence in Reactome rather than the core molecular role of ARIH1; keep it as non-core while prioritizing ubiquitin/ubiquitin-like ligase activity.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	23	R-HSA-1169394	ISGylation of IRF3	yes	reactome/R-HSA-1169394.md	ISGylation of IRF3	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	24	R-HSA-1169395	ISGylation of viral protein NS1	yes	reactome/R-HSA-1169395.md	ISGylation of viral protein NS1	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	25	R-HSA-1169398	ISGylation of host protein filamin B	yes	reactome/R-HSA-1169398.md	ISGylation of host protein filamin B	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	26	R-HSA-1169402	ISGylation of E2 conjugating enzymes	yes	reactome/R-HSA-1169402.md	ISGylation of E2 conjugating enzymes	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	27	R-HSA-1169405	ISGylation of protein phosphatase 1 beta (PP2CB)	yes	reactome/R-HSA-1169405.md	ISGylation of protein phosphatase 1 beta (PP2CB)	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	28	R-HSA-1169406	ISGylation of host proteins	yes	reactome/R-HSA-1169406.md	ISGylation of host proteins	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	29	R-HSA-9833973	ISGylation of PKR	yes	reactome/R-HSA-9833973.md	ISGylation of PKR	Homo sapiens	GO:0061662	ISG15 ligase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	ISG15 ligase activity is retained as a confirmed secondary ubiquitin-like/ISGylation function: UniProt explicitly states that ARIH1 acts as the ligase involved in ISGylation of EIF4E2, while the dominant core function remains ubiquitin transfer with neddylated CRLs.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	50	R-HSA-1169394	ISGylation of IRF3	yes	reactome/R-HSA-1169394.md	ISGylation of IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	51	R-HSA-1169395	ISGylation of viral protein NS1	yes	reactome/R-HSA-1169395.md	ISGylation of viral protein NS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	52	R-HSA-1169398	ISGylation of host protein filamin B	yes	reactome/R-HSA-1169398.md	ISGylation of host protein filamin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	53	R-HSA-1169402	ISGylation of E2 conjugating enzymes	yes	reactome/R-HSA-1169402.md	ISGylation of E2 conjugating enzymes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	54	R-HSA-1169403	Interaction of E3 ligase with ISG15:E2 complex	yes	reactome/R-HSA-1169403.md	Interaction of E3 ligase with ISG15:E2 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	55	R-HSA-1169405	ISGylation of protein phosphatase 1 beta (PP2CB)	yes	reactome/R-HSA-1169405.md	ISGylation of protein phosphatase 1 beta (PP2CB)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	56	R-HSA-1169406	ISGylation of host proteins	yes	reactome/R-HSA-1169406.md	ISGylation of host proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	57	R-HSA-1678843	ISGylation of protein translation regulator 4EHP	yes	reactome/R-HSA-1678843.md	ISGylation of protein translation regulator 4EHP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	58	R-HSA-9833973	ISGylation of PKR	yes	reactome/R-HSA-9833973.md	ISGylation of PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	59	R-HSA-9837231	ISGylation of BECN1	yes	reactome/R-HSA-9837231.md	ISGylation of BECN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARIH1	genes/human/ARIH1/ARIH1-ai-review.yaml	ARIH1	Q9Y4X5	NCBITaxon:9606	Homo sapiens	60	R-HSA-9927247	ISGylation of DDX58 (RIG-I)	yes	reactome/R-HSA-9927247.md	ISGylation of DDX58 (RIG-I)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for intracellular ARIH1; the most relevant functional locations are cytoplasm/cytosol and nucleus.
human	ARL2BP	genes/human/ARL2BP/ARL2BP-ai-review.yaml	ARL2BP	Q9Y2Y0	NCBITaxon:9606	Homo sapiens	35	R-HSA-5250209	ARL2:GTP:ARL2BP binds SLC25A4	yes	reactome/R-HSA-5250209.md	ARL2:GTP:ARL2BP binds SLC25A4	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		UNDECIDED	The exact model does not yet resolve the side occupied by ARL2BP.
human	ARL2BP	genes/human/ARL2BP/ARL2BP-ai-review.yaml	ARL2BP	Q9Y2Y0	NCBITaxon:9606	Homo sapiens	36	R-HSA-5250210	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix	yes	reactome/R-HSA-5250210.md	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		UNDECIDED	The reaction title and summary leave a compartment ambiguity.
human	ARL2BP	genes/human/ARL2BP/ARL2BP-ai-review.yaml	ARL2BP	Q9Y2Y0	NCBITaxon:9606	Homo sapiens	37	R-HSA-5672027	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane	yes	reactome/R-HSA-5672027.md	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		UNDECIDED	Nucleotide transport context does not establish the ARL2BP compartment.
human	ARL2BP	genes/human/ARL2BP/ARL2BP-ai-review.yaml	ARL2BP	Q9Y2Y0	NCBITaxon:9606	Homo sapiens	42	R-HSA-5250210	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix	yes	reactome/R-HSA-5250210.md	ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Retain the independently supported cytosolic starting pool.
human	ARL2BP	genes/human/ARL2BP/ARL2BP-ai-review.yaml	ARL2BP	Q9Y2Y0	NCBITaxon:9606	Homo sapiens	43	R-HSA-5250217	ARL2:GTP binds ARL2BP	yes	reactome/R-HSA-5250217.md	ARL2:GTP binds ARL2BP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic ARL2–ARL2BP association is consistent with localization evidence.
human	ARL6	genes/human/ARL6/ARL6-ai-review.yaml	ARL6	Q9H0F7	NCBITaxon:9606	Homo sapiens	18	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005929	cilium	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of ciliary localization, consistent with experimental data.
human	ARL6	genes/human/ARL6/ARL6-ai-review.yaml	ARL6	Q9H0F7	NCBITaxon:9606	Homo sapiens	20	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assertion. ARL6 acts at the plasma/ciliary membrane interface; GTP-bound ARL6 binds the (ciliary) membrane where it recruits the BBSome and cargo.
human	ARL6	genes/human/ARL6/ARL6-ai-review.yaml	ARL6	Q9H0F7	NCBITaxon:9606	Homo sapiens	21	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome plasma membrane assertion.
human	ARL8A	genes/human/ARL8A/ARL8A-ai-review.yaml	ARL8A	Q96BM9	NCBITaxon:9606	Homo sapiens	25	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		REMOVE	plasma membrane is a Reactome granule-exocytosis context and is not supported as an ARL8A steady-state location.
human	ARL8A	genes/human/ARL8A/ARL8A-ai-review.yaml	ARL8A	Q96BM9	NCBITaxon:9606	Homo sapiens	26	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		REMOVE	plasma membrane is a Reactome granule-exocytosis context and is not supported as an ARL8A steady-state location.
human	ARL8A	genes/human/ARL8A/ARL8A-ai-review.yaml	ARL8A	Q96BM9	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		REMOVE	azurophil granule membrane is a Reactome granule-exocytosis context and is not supported as an ARL8A steady-state location.
human	ARL8A	genes/human/ARL8A/ARL8A-ai-review.yaml	ARL8A	Q96BM9	NCBITaxon:9606	Homo sapiens	28	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		REMOVE	ficolin-1-rich granule membrane is a Reactome granule-exocytosis context and is not supported as an ARL8A steady-state location.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	40	R-HSA-8937144	Aryl hydrocarbon receptor signalling	yes	reactome/R-HSA-8937144.md	Aryl hydrocarbon receptor signalling	Homo sapiens	GO:0006805	xenobiotic metabolic process	TAS	involved_in	BP	false		ACCEPT	Xenobiotic metabolic process is supported through the AHR-ARNT transcriptional response.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	42	R-HSA-8937177	AHR:TCDD binds ARNT	yes	reactome/R-HSA-8937177.md	AHR:TCDD binds ARNT	Homo sapiens	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	TAS	enables	MF	false		ACCEPT	DNA-binding transcription activator activity, RNA polymerase II-specific captures the transcription-factor activity of ARNT-containing RNA polymerase II regulatory complexes.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	56	R-HSA-1234167	Formation of HIF:CBP:p300 complex at promoters	yes	reactome/R-HSA-1234167.md	Formation of HIF:CBP:p300 complex at promoters	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported nuclear localization for ARNT.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	57	R-HSA-1234171	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT	yes	reactome/R-HSA-1234171.md	HIF-alpha binds ARNT (HIF1-beta) forming HIF-alpha:ARNT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported nuclear localization for ARNT.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	58	R-HSA-8936851	AHRR binds ARNT	yes	reactome/R-HSA-8936851.md	AHRR binds ARNT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported nuclear localization for ARNT.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	59	R-HSA-8937177	AHR:TCDD binds ARNT	yes	reactome/R-HSA-8937177.md	AHR:TCDD binds ARNT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported nuclear localization for ARNT.
human	ARNT	genes/human/ARNT/ARNT-ai-review.yaml	ARNT	P27540	NCBITaxon:9606	Homo sapiens	60	R-HSA-9634850	NPAS4 binds ARNT	yes	reactome/R-HSA-9634850.md	NPAS4 binds ARNT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a supported nuclear localization for ARNT.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	7	R-HSA-1861595	Extension of pseudopodia by myosin-X in a PI3K dependent manner	yes	reactome/R-HSA-1861595.md	Extension of pseudopodia by myosin-X in a PI3K dependent manner	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is independently supported in the myosin-X event context.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	8	R-HSA-2029466	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	yes	reactome/R-HSA-2029466.md	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The branching event is compatible with an independently observed cytosolic pool.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	9	R-HSA-2029473	Branching and elongation of mother and daughter filaments	yes	reactome/R-HSA-2029473.md	Branching and elongation of mother and daughter filaments	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The filament-elongation context does not change the supported cytosol call.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	10	R-HSA-2029476	Role of myosins in phagosome formation	yes	reactome/R-HSA-2029476.md	Role of myosins in phagosome formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The myosin-dependent internalization model is a contextual cytosol source.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	11	R-HSA-2197690	Detachment of WASP/WAVE	yes	reactome/R-HSA-2197690.md	Detachment of WASP/WAVE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	WASP/WAVE release is compatible with the cytosolic actin-complex pool.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	12	R-HSA-3928595	N-WASP binds ARP2/3 and G-actin	yes	reactome/R-HSA-3928595.md	N-WASP binds ARP2/3 and G-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The N-WASP model provides complex context, with independent target location support.
human	ARPC1B	genes/human/ARPC1B/ARPC1B-ai-review.yaml	ARPC1B	O15143	NCBITaxon:9606	Homo sapiens	13	R-HSA-9666458	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole	yes	reactome/R-HSA-9666458.md	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The receptor-internalization model is retained as a contextual cytosol source.
human	ARPP19	genes/human/ARPP19/ARPP19-ai-review.yaml	ARPP19	P56211	NCBITaxon:9606	Homo sapiens	11	R-HSA-2168079	MASTL (GWL) phosphorylates ARPP19	yes	reactome/R-HSA-2168079.md	MASTL (GWL) phosphorylates ARPP19	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the MASTL-ARPP19 Ser62 phosphorylation reaction in the nucleoplasm.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	17	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled extracellular ARSA pool as a non-core location.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled azurophil-granule ARSA pool as a non-core location.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	20	R-HSA-1614362	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	yes	reactome/R-HSA-1614362.md	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain ER-lumen ARSA maturation by SUMF1 as a non-core location.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	21	R-HSA-2248891	M6PR transports activated ARSA to the lysosome	yes	reactome/R-HSA-2248891.md	M6PR transports activated ARSA to the lysosome	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain ER-lumen transit of ARSA cargo as non-core.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	22	R-HSA-1606807	ARSA removes sulfate from PSAP(195-273):Sulfatide	yes	reactome/R-HSA-1606807.md	ARSA removes sulfate from PSAP(195-273):Sulfatide	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept the lysosomal-lumen site of sulfatide hydrolysis.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	23	R-HSA-2248891	M6PR transports activated ARSA to the lysosome	yes	reactome/R-HSA-2248891.md	M6PR transports activated ARSA to the lysosome	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept lysosomal-lumen delivery of active ARSA.
human	ARSA	genes/human/ARSA/ARSA-ai-review.yaml	ARSA	P15289	NCBITaxon:9606	Homo sapiens	24	R-HSA-9840949	ARSA removes sulfate from SM3	yes	reactome/R-HSA-9840949.md	ARSA removes sulfate from SM3	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept lysosomal-lumen ARSA catalysis of SM3 desulfation.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	17	R-HSA-2282889	Defective ARSB does not hydrolyse C4S/C6S chains	yes	reactome/R-HSA-2282889.md	Defective ARSB does not hydrolyse C4S/C6S chains	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept the independently corroborated lysosomal-lumen compartment.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	18	R-HSA-9036065	Defective ARSB does not hydrolyse DS	yes	reactome/R-HSA-9036065.md	Defective ARSB does not hydrolyse DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept lysosomal lumen without adopting ambiguous mutant-reaction wording.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled extracellular granule-cargo pool as non-core.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	20	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled extracellular ficolin-rich-granule cargo pool as non-core.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled azurophil-granule lumen location as non-core.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	22	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled ficolin-rich-granule lumen location as non-core.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	29	R-HSA-1614362	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	yes	reactome/R-HSA-1614362.md	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain ER-lumen maturation cargo localization as non-core.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	30	R-HSA-1606789	ARSB hydrolyses DS	yes	reactome/R-HSA-1606789.md	ARSB hydrolyses DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept the lysosomal-lumen site of human ARSB-catalyzed DS desulfation.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	31	R-HSA-1793207	ARSB hydrolyses C4S/C6S chains	yes	reactome/R-HSA-1793207.md	ARSB hydrolyses C4S/C6S chains	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Accept the lysosomal-lumen catalyst location in CS degradation.
human	ARSB	genes/human/ARSB/ARSB-ai-review.yaml	ARSB	P15848	NCBITaxon:9606	Homo sapiens	36	R-HSA-1606789	ARSB hydrolyses DS	yes	reactome/R-HSA-1606789.md	ARSB hydrolyses DS	Homo sapiens	GO:0030209	dermatan sulfate proteoglycan catabolic process	TAS		UNKNOWN	false		NEW	Retain the proposal for ARSB-catalyzed dermatan sulfate degradation.
human	ARSI	genes/human/ARSI/ARSI-ai-review.yaml	ARSI	Q5FYB1	NCBITaxon:9606	Homo sapiens	9	R-HSA-1614362	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	yes	reactome/R-HSA-1614362.md	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places ARSI in the ER lumen for SUMF1-mediated conversion of its catalytic cysteine to formylglycine.
human	ARSJ	genes/human/ARSJ/ARSJ-ai-review.yaml	ARSJ	Q5FYB0	NCBITaxon:9606	Homo sapiens	6	R-HSA-1614362	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	yes	reactome/R-HSA-1614362.md	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places ARSJ in the ER lumen during SUMF1-mediated conversion of its catalytic cysteine to formylglycine.
human	ARSL	genes/human/ARSL/ARSL-ai-review.yaml	ARSL	P51690	NCBITaxon:9606	Homo sapiens	8	R-HSA-1614362	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	yes	reactome/R-HSA-1614362.md	SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled ER-lumen precursor and maturation location.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	45	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled extracellular region location as non-core.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	46	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled extracellular region location as non-core.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	47	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled tertiary granule lumen location as non-core.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	48	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the modeled ficolin-1-rich granule lumen location as non-core.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	52	R-HSA-1606602	ASAH1 hydrolyzes ceramide	yes	reactome/R-HSA-1606602.md	ASAH1 hydrolyzes ceramide	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome annotation ('ASAH1 hydrolyzes ceramide') placing the enzyme in the lysosomal lumen.
human	ASAH1	genes/human/ASAH1/ASAH1-ai-review.yaml	ASAH1	Q13510	NCBITaxon:9606	Homo sapiens	53	R-HSA-9859104	MITF-M-dependent ASAH1 expression	yes	reactome/R-HSA-9859104.md	MITF-M-dependent ASAH1 expression	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Retain the lysosomal-lumen product location recorded in the expression event.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	17	R-HSA-112123	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	yes	reactome/R-HSA-112123.md	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3/ASCC-dependent oxidative demethylation of 1-meA damaged DNA in the nucleoplasm.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	18	R-HSA-112124	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	yes	reactome/R-HSA-112124.md	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3/ASCC-dependent oxidative demethylation of 3-meC damaged DNA in the nucleoplasm.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	19	R-HSA-112125	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	yes	reactome/R-HSA-112125.md	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3/ASCC-dependent oxidative dealkylation of 1-etA damaged DNA in the nucleoplasm.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	20	R-HSA-5657617	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	yes	reactome/R-HSA-5657617.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome models ALKBH3 associated with ASCC1:ASCC2:ASCC3 binding 3-meC-containing alkylated dsDNA.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	21	R-HSA-5657637	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	yes	reactome/R-HSA-5657637.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome models ALKBH3 associated with ASCC1:ASCC2:ASCC3 binding 1-meA-containing alkylated dsDNA.
human	ASCC1	genes/human/ASCC1/ASCC1-ai-review.yaml	ASCC1	Q8N9N2	NCBITaxon:9606	Homo sapiens	22	R-HSA-5657642	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	yes	reactome/R-HSA-5657642.md	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome models ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binding 1-etA-containing alkylated DNA.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	10	R-HSA-9948291	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948291.md	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places ASCC2 in cytosolic RQT binding of K63-polyubiquitinated stalled ribosomes.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	11	R-HSA-9948300	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places ASCC2 in cytosolic RQT-mediated splitting of stalled K63-polyubiquitinated ribosomes.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	33	R-HSA-112123	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	yes	reactome/R-HSA-112123.md	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3/ASCC repair reactions in the nucleoplasm.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	34	R-HSA-112124	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	yes	reactome/R-HSA-112124.md	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3-mediated oxidative demethylation of alkylated DNA in the nucleoplasm.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	35	R-HSA-112125	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	yes	reactome/R-HSA-112125.md	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ALKBH3-associated ASCC repair of ethylated DNA in the nucleoplasm.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	36	R-HSA-5657617	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	yes	reactome/R-HSA-5657617.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ASCC1:ASCC2:ASCC3-associated ALKBH3 binding to alkylated DNA in the nucleoplasm.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	37	R-HSA-5657637	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	yes	reactome/R-HSA-5657637.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ASCC-associated ALKBH3 binding to 1-meA-containing alkylated DNA in the nucleoplasm.
human	ASCC2	genes/human/ASCC2/ASCC2-ai-review.yaml	ASCC2	Q9H1I8	NCBITaxon:9606	Homo sapiens	38	R-HSA-5657642	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	yes	reactome/R-HSA-5657642.md	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places ASCC-associated ALKBH3 binding to 1-etA-containing alkylated DNA in the nucleoplasm.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	18	R-HSA-9948299	Ribosome-associated quality control	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Rescue of stalled cytosolic ribosomes is the PN-relevant core process for ASCC3/hRQT.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	22	R-HSA-9948300	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	ATP hydrolysis activity is directly tied to ASCC3 helicase-dependent DNA repair and hRQT ribosome splitting.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	23	R-HSA-9948291	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948291.md	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is supported by the ribosome-associated quality-control role.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	24	R-HSA-9948300	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is supported by the ribosome-associated quality-control role.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	43	R-HSA-112123	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	yes	reactome/R-HSA-112123.md	Oxidative demethylation of 1-meA damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	44	R-HSA-112124	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	yes	reactome/R-HSA-112124.md	Oxidative demethylation of 3-meC damaged DNA By ALKBH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	45	R-HSA-112125	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	yes	reactome/R-HSA-112125.md	Oxidative dealkylation of 1-EtA damaged DNA by ABH3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	46	R-HSA-5657617	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	yes	reactome/R-HSA-5657617.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 3-meC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	47	R-HSA-5657637	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	yes	reactome/R-HSA-5657637.md	ALKBH3 associated with ASCC1:ASCC2:ASCC3 binds alkylated dsDNA containing 1-meA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASCC3	genes/human/ASCC3/ASCC3-ai-review.yaml	ASCC3	Q8N3C0	NCBITaxon:9606	Homo sapiens	48	R-HSA-5657642	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	yes	reactome/R-HSA-5657642.md	ALKBH3 in complex with ASCC1:ASCC2:ASCC3 binds alkylated DNA containing 1-etA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm annotations from Reactome ALKBH3 repair events are consistent with ASCC3 nuclear DNA repair function.
human	ASH1L	genes/human/ASH1L/ASH1L-ai-review.yaml	ASH1L	Q9NR48	NCBITaxon:9606	Homo sapiens	8	R-HSA-4827383	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)	yes	reactome/R-HSA-4827383.md	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is consistent with ASH1L chromatin catalysis.
human	ASH1L	genes/human/ASH1L/ASH1L-ai-review.yaml	ASH1L	Q9NR48	NCBITaxon:9606	Homo sapiens	9	R-HSA-5638157	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)	yes	reactome/R-HSA-5638157.md	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is the supported compartment for ASH1L histone methylation.
human	ASH1L	genes/human/ASH1L/ASH1L-ai-review.yaml	ASH1L	Q9NR48	NCBITaxon:9606	Homo sapiens	24	R-HSA-4827383	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)	yes	reactome/R-HSA-4827383.md	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)	Homo sapiens	GO:0140938	histone H3 methyltransferase activity	TAS	enables	MF	false		MODIFY	Replace broad H3 methyltransferase activity with K36 dimethylation.
human	ASH1L	genes/human/ASH1L/ASH1L-ai-review.yaml	ASH1L	Q9NR48	NCBITaxon:9606	Homo sapiens	25	R-HSA-5638157	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)	yes	reactome/R-HSA-5638157.md	WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)	Homo sapiens	GO:0140938	histone H3 methyltransferase activity	TAS	enables	MF	false		MODIFY	The reaction supports the specific H3K36 dimethyltransferase activity.
human	ASL	genes/human/ASL/ASL-ai-review.yaml	ASL	P04424	NCBITaxon:9606	Homo sapiens	18	R-HSA-9956524	ASL variants don't synthesize fumarate and arginine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization (from the ASL variant urea-cycle reaction pathway). ASL is a soluble cytosolic enzyme.
human	ASL	genes/human/ASL/ASL-ai-review.yaml	ASL	P04424	NCBITaxon:9606	Homo sapiens	28	R-HSA-70573	argininosuccinate <=> fumarate + arginine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization (from the argininosuccinate to fumarate + arginine urea-cycle reaction). Correct.
human	ASMT	genes/human/ASMT/ASMT-ai-review.yaml	ASMT	P46597	NCBITaxon:9606	Homo sapiens	9	R-HSA-209931	Serotonin and melatonin biosynthesis	yes	reactome/R-HSA-209931.md	Serotonin and melatonin biosynthesis	Homo sapiens	GO:0046219	indolalkylamine biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	TAS (Reactome) annotation to indolalkylamine biosynthetic process. Melatonin (N-acetyl-5-methoxytryptamine) is an indolalkylamine, so this is correct, but it is a broad parent of the specific melatonin biosynthetic process (GO:0030187). Keep as non-core.
human	ASMT	genes/human/ASMT/ASMT-ai-review.yaml	ASMT	P46597	NCBITaxon:9606	Homo sapiens	11	R-HSA-209821	Methylation of N-acetyl-5-HT to form melatonin	yes	reactome/R-HSA-209821.md	Methylation of N-acetyl-5-HT to form melatonin	Homo sapiens	GO:0008172	S-methyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	TAS (Reactome) annotation to S-methyltransferase activity. This is the WRONG MOLECULAR-FUNCTION BRANCH: S-methyltransferases transfer a methyl group to a sulfur atom, whereas ASMT is definitively an O-methyltransferase (EC 2.1.1.4) that methylates the 5-hydroxyl oxygen of N-acetylserotonin. This is a Reactome-to-GO mapping artifact (the reaction consumes SAM, but the acceptor atom is oxygen, not sulfur). Not experimental. Mark as over-annotated; the correct MF is GO:0017096 / GO:0008171.
human	ASMT	genes/human/ASMT/ASMT-ai-review.yaml	ASMT	P46597	NCBITaxon:9606	Homo sapiens	15	R-HSA-209821	Methylation of N-acetyl-5-HT to form melatonin	yes	reactome/R-HSA-209821.md	Methylation of N-acetyl-5-HT to form melatonin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to cytosol. ASMT is a soluble class I-like SAM-dependent O-methyltransferase with no transit peptide or membrane anchor, consistent with a cytosolic location. Accept as the core cellular location.
human	ASPA	genes/human/ASPA/ASPA-ai-review.yaml	ASPA	P45381	NCBITaxon:9606	Homo sapiens	19	R-HSA-5691507	ASPA deacetylates NAASP to acetate and L-aspartate	yes	reactome/R-HSA-5691507.md	ASPA deacetylates NAASP to acetate and L-aspartate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	
human	ASS1	genes/human/ASS1/ASS1-ai-review.yaml	ASS1	P00966	NCBITaxon:9606	Homo sapiens	56	R-HSA-9956517	ASS1 variants don't synthesize arginosuccinate	yes	reactome/R-HSA-9956517.md	ASS1 variants don't synthesize arginosuccinate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The curated variant reaction occurs in the cytosol.
human	ASS1	genes/human/ASS1/ASS1-ai-review.yaml	ASS1	P00966	NCBITaxon:9606	Homo sapiens	78	R-HSA-70577	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA	yes	reactome/R-HSA-70577.md	ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The normal human ASS1 reaction is assigned to the cytosol.
human	ASXL1	genes/human/ASXL1/ASXL1-ai-review.yaml	ASXL1	Q8IXJ9	NCBITaxon:9606	Homo sapiens	18	R-HSA-5689630	BAP1 binds BAP1-interacting complex	yes	reactome/R-HSA-5689630.md	BAP1 binds BAP1-interacting complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization agrees with independent ASXL1 evidence.
human	ASXL1	genes/human/ASXL1/ASXL1-ai-review.yaml	ASXL1	Q8IXJ9	NCBITaxon:9606	Homo sapiens	19	R-HSA-5690790	Histone H2A is dubiquitinated by the PR-DUB complex	yes	reactome/R-HSA-5690790.md	Histone H2A is dubiquitinated by the PR-DUB complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic PR-DUB localization is supported.
human	ASXL2	genes/human/ASXL2/ASXL2-ai-review.yaml	ASXL2	Q76L83	NCBITaxon:9606	Homo sapiens	6	R-HSA-5689630	BAP1 binds BAP1-interacting complex	yes	reactome/R-HSA-5689630.md	BAP1 binds BAP1-interacting complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The modeled BAP1 assembly includes nucleoplasmic ASXL2.
human	ASXL2	genes/human/ASXL2/ASXL2-ai-review.yaml	ASXL2	Q76L83	NCBITaxon:9606	Homo sapiens	7	R-HSA-5690790	Histone H2A is dubiquitinated by the PR-DUB complex	yes	reactome/R-HSA-5690790.md	Histone H2A is dubiquitinated by the PR-DUB complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The modeled PR-DUB reaction includes nucleoplasmic ASXL2.
human	ATAD1	genes/human/ATAD1/ATAD1-ai-review.yaml	ATAD1	Q8NBU5	NCBITaxon:9606	Homo sapiens	23	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome treats ATAD1 as a class I peroxisomal membrane protein in the PEX19/PEX3 import pathway.
human	ATAD1	genes/human/ATAD1/ATAD1-ai-review.yaml	ATAD1	Q8NBU5	NCBITaxon:9606	Homo sapiens	24	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	The cytosol localization appears to come from the PEX19 cytosolic step in peroxisomal membrane protein import rather than ATAD1 itself.
human	ATAD1	genes/human/ATAD1/ATAD1-ai-review.yaml	ATAD1	Q8NBU5	NCBITaxon:9606	Homo sapiens	25	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	This Reactome cytosol annotation reflects cytosolic PEX19-cargo handling, not a soluble ATAD1 pool.
human	ATAD1	genes/human/ATAD1/ATAD1-ai-review.yaml	ATAD1	Q8NBU5	NCBITaxon:9606	Homo sapiens	26	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Reactome explicitly places PEX19 in the cytosol; ATAD1 is one of the membrane protein cargos listed in the same pathway context.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	78	R-HSA-3318415	ATF2 acetylates histone H2B, H4	yes	reactome/R-HSA-3318415.md	ATF2 acetylates histone H2B, H4	Homo sapiens	GO:0004402	histone acetyltransferase activity	TAS	enables	MF	false		UNDECIDED	ATF2 has reported intrinsic HAT activity toward H2B and H4 (PMID:10821277, Kawasaki et al. 2000, Nature). However, UniProt notes a CAUTION that this activity may be due to contamination. Reactome pathway R-HSA-3318415 describes ATF2 acetylating H2B and H4.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	123	R-HSA-168053	Phosphorylated MAPKs phosphorylate ATF-2	yes	reactome/R-HSA-168053.md	Phosphorylated MAPKs phosphorylate ATF-2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-168053. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	124	R-HSA-168440	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.	yes	reactome/R-HSA-168440.md	Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-168440. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	125	R-HSA-3318415	ATF2 acetylates histone H2B, H4	yes	reactome/R-HSA-3318415.md	ATF2 acetylates histone H2B, H4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-3318415. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	126	R-HSA-6806412	TP53 and AP-1 bind the MSH2 promoter	yes	reactome/R-HSA-6806412.md	TP53 and AP-1 bind the MSH2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-6806412. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	127	R-HSA-8944397	p-T69,T71-ATF2 binds PTEN gene promoter	yes	reactome/R-HSA-8944397.md	p-T69,T71-ATF2 binds PTEN gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-8944397. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	128	R-HSA-9009371	Binding of AP1 transcriptional activator complexes to CCND1 promoter	yes	reactome/R-HSA-9009371.md	Binding of AP1 transcriptional activator complexes to CCND1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-9009371. ATF2 is a nuclear transcription factor.
human	ATF2	genes/human/ATF2/ATF2-ai-review.yaml	ATF2	P15336	NCBITaxon:9606	Homo sapiens	129	R-HSA-9635804	ATF4 and phospho-ATF2 bind the DDIT3 promoter	yes	reactome/R-HSA-9635804.md	ATF4 and phospho-ATF2 bind the DDIT3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-9635804. ATF2 is a nuclear transcription factor.
human	ATF3	genes/human/ATF3/ATF3-ai-review.yaml	ATF3	P18847	NCBITaxon:9606	Homo sapiens	77	R-HSA-9653893	ATF4, CEBPB, and ATF3 bind the CHAC1 promoter	yes	reactome/R-HSA-9653893.md	ATF4, CEBPB, and ATF3 bind the CHAC1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is consistent with ATF3 acting as a nuclear transcription factor.
human	ATF3	genes/human/ATF3/ATF3-ai-review.yaml	ATF3	P18847	NCBITaxon:9606	Homo sapiens	78	R-HSA-9909594	ATF3 binding to CD274 gene	yes	reactome/R-HSA-9909594.md	ATF3 binding to CD274 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is consistent with ATF3 acting as a nuclear transcription factor.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	155	R-HSA-9796061	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9796061.md	NFE2L2 dependent ATF4 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ATF4 is synthesized in the cytosol.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	189	R-HSA-9635804	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9635804.md	ATF4 and phospho-ATF2 bind the DDIT3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATF4 nucleoplasmic localization in Reactome pathway.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	190	R-HSA-9635892	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9635892.md	ATF4 binds the ATF3 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATF4 nucleoplasmic localization.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	191	R-HSA-9635936	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9635936.md	ATF4 binds the CEBPB gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATF4 nucleoplasmic localization.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	192	R-HSA-9653893	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9653893.md	ATF4, CEBPB, and ATF3 bind the CHAC1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATF4 nucleoplasmic localization.
human	ATF4	genes/human/ATF4/ATF4-ai-review.yaml	ATF4	P18848	NCBITaxon:9606	Homo sapiens	193	R-HSA-9761815	Reactome pathway involving ATF4.	yes	reactome/R-HSA-9761815.md	AcK-NFE2L2 and ATF4 bind the SLC7A11 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATF4 nucleoplasmic localization.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	3	R-HSA-381135	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)	yes	reactome/R-HSA-381135.md	MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain supported Golgi membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	4	R-HSA-381186	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi	yes	reactome/R-HSA-381186.md	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain supported Golgi membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	5	R-HSA-420818	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)	yes	reactome/R-HSA-420818.md	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Retain supported Golgi membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	39	R-HSA-381026	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus	yes	reactome/R-HSA-381026.md	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	48	R-HSA-381158	ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein	yes	reactome/R-HSA-381158.md	ATF6:HSPA5 (ATF6-alpha:BiP) dissociates and HSPA5 binds unfolded protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain supported endoplasmic reticulum membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	49	R-HSA-381186	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi	yes	reactome/R-HSA-381186.md	ATF6 (ATF6-alpha) translocates from the endoplasmic reticulum to the Golgi	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain supported endoplasmic reticulum membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	50	R-HSA-9921802	IFI6 binds HSPA5	yes	reactome/R-HSA-9921802.md	IFI6 binds HSPA5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Retain supported endoplasmic reticulum membrane.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	53	R-HSA-381026	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus	yes	reactome/R-HSA-381026.md	ATF6 (ATF6-alpha) translocates from the cytosol to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosol as a contextual annotation.
human	ATF6	genes/human/ATF6/ATF6-ai-review.yaml	ATF6	P18850	NCBITaxon:9606	Homo sapiens	54	R-HSA-420818	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)	yes	reactome/R-HSA-420818.md	MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosol as a contextual annotation.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	40	R-HSA-5205663	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-5205663.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ATG12-containing conjugation machinery can associate with phagosomes.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	41	R-HSA-8959571	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-8959571.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ATG12-containing conjugation machinery can associate with phagosomes.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	42	R-HSA-5678490	ATG16L1 complex transfers LC3 from ATG3 to PE	yes	reactome/R-HSA-5678490.md	ATG16L1 complex transfers LC3 from ATG3 to PE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	43	R-HSA-5679255	WIPI2 binds ATG12:ATG5:ATG16L	yes	reactome/R-HSA-5679255.md	WIPI2 binds ATG12:ATG5:ATG16L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	44	R-HSA-5681980	ATG12 binds ATG7 dimer	yes	reactome/R-HSA-5681980.md	ATG12 binds ATG7 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	45	R-HSA-5682010	ATG10:ATG12 binds ATG5	yes	reactome/R-HSA-5682010.md	ATG10:ATG12 binds ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	46	R-HSA-5682012	ATG5:ATG12 binds ATG16L1	yes	reactome/R-HSA-5682012.md	ATG5:ATG12 binds ATG16L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	47	R-HSA-5682690	ATG10 dissociates from ATG12:ATG5	yes	reactome/R-HSA-5682690.md	ATG10 dissociates from ATG12:ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	48	R-HSA-5683588	ATG10 transfers ATG12 from ATG10 to ATG5	yes	reactome/R-HSA-5683588.md	ATG10 transfers ATG12 from ATG10 to ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	49	R-HSA-9020616	ATG12 forms a thioester bond with ATG7 dimer	yes	reactome/R-HSA-9020616.md	ATG12 forms a thioester bond with ATG7 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG12	genes/human/ATG12/ATG12-ai-review.yaml	ATG12	O94817	NCBITaxon:9606	Homo sapiens	50	R-HSA-9936620	ATG5:ATG12 binds ATG16L2	yes	reactome/R-HSA-9936620.md	ATG5:ATG12 binds ATG16L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a core location for the ATG12 conjugation machinery.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	63	R-HSA-5682385	The phagophore extends from the PIP3-enriched structure	yes	reactome/R-HSA-5682385.md	The phagophore extends from the PIP3-enriched structure	Homo sapiens	GO:0034045	phagophore assembly site membrane	TAS	located_in	CC	false		MODIFY	Localization to the phagophore membrane is supported.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	74	R-HSA-5672012	Beclin-1 complex phosphorylates PtdIns	yes	reactome/R-HSA-5672012.md	Beclin-1 complex phosphorylates PtdIns	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	75	R-HSA-5679205	ULK1 phosphorylates Beclin-1	yes	reactome/R-HSA-5679205.md	ULK1 phosphorylates Beclin-1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	76	R-HSA-5679266	Beclin-1 complex translocates to the ER	yes	reactome/R-HSA-5679266.md	Beclin-1 complex translocates to the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	77	R-HSA-5682385	The phagophore extends from the PIP3-enriched structure	yes	reactome/R-HSA-5682385.md	The phagophore extends from the PIP3-enriched structure	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	78	R-HSA-9755359	SARS-CoV-2 8:class I MHC binds BECN1	yes	reactome/R-HSA-9755359.md	SARS-CoV-2 8:class I MHC binds BECN1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	79	R-HSA-9921171	NS1 binds Beclin-1	yes	reactome/R-HSA-9921171.md	NS1 binds Beclin-1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane localization is a core ATG14 autophagy-initiation context.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	84	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is supported as a broad ATG14 location in nutrient-rich cells and Reactome events.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	85	R-HSA-5678313	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	yes	reactome/R-HSA-5678313.md	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is supported as a broad ATG14 location in nutrient-rich cells and Reactome events.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	86	R-HSA-5678315	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	yes	reactome/R-HSA-5678315.md	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is supported as a broad ATG14 location in nutrient-rich cells and Reactome events.
human	ATG14	genes/human/ATG14/ATG14-ai-review.yaml	ATG14	Q6ZNE5	NCBITaxon:9606	Homo sapiens	87	R-HSA-5679266	Beclin-1 complex translocates to the ER	yes	reactome/R-HSA-5679266.md	Beclin-1 complex translocates to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is supported as a broad ATG14 location in nutrient-rich cells and Reactome events.
human	ATG16L1	genes/human/ATG16L1/ATG16L1-ai-review.yaml	ATG16L1	Q676U5	NCBITaxon:9606	Homo sapiens	35	R-HSA-1632852	Macroautophagy	yes	reactome/R-HSA-1632852.md	Macroautophagy	Homo sapiens	GO:0016236	macroautophagy	TAS	involved_in	BP	false		ACCEPT	Macroautophagy, the canonical pathway ATG16L1 serves.
human	ATG16L1	genes/human/ATG16L1/ATG16L1-ai-review.yaml	ATG16L1	Q676U5	NCBITaxon:9606	Homo sapiens	48	R-HSA-5678490	ATG16L1 complex transfers LC3 from ATG3 to PE	yes	reactome/R-HSA-5678490.md	ATG16L1 complex transfers LC3 from ATG3 to PE	Homo sapiens	GO:0019787	ubiquitin-like protein transferase activity	TAS	enables	MF	false		MODIFY	Ubiquitin-like protein transferase activity. Correct in kind but two levels too general; the specific term exists.
human	ATG16L1	genes/human/ATG16L1/ATG16L1-ai-review.yaml	ATG16L1	Q676U5	NCBITaxon:9606	Homo sapiens	66	R-HSA-5678490	ATG16L1 complex transfers LC3 from ATG3 to PE	yes	reactome/R-HSA-5678490.md	ATG16L1 complex transfers LC3 from ATG3 to PE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, the soluble pool of a peripherally membrane-associated complex.
human	ATG16L1	genes/human/ATG16L1/ATG16L1-ai-review.yaml	ATG16L1	Q676U5	NCBITaxon:9606	Homo sapiens	67	R-HSA-5679255	WIPI2 binds ATG12:ATG5:ATG16L	yes	reactome/R-HSA-5679255.md	WIPI2 binds ATG12:ATG5:ATG16L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, the soluble pool of a peripherally membrane-associated complex.
human	ATG16L1	genes/human/ATG16L1/ATG16L1-ai-review.yaml	ATG16L1	Q676U5	NCBITaxon:9606	Homo sapiens	68	R-HSA-5682012	ATG5:ATG12 binds ATG16L1	yes	reactome/R-HSA-5682012.md	ATG5:ATG12 binds ATG16L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, the soluble pool of a peripherally membrane-associated complex.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	68	R-HSA-5205663	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-5205663.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for LC3-associated phagocytosis (LAP). ATG5 participates in LC3 lipidation on phagosome membranes during LAP.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	69	R-HSA-8959571	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-8959571.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for phagocytic vesicle membrane localization.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	71	R-HSA-5678490	ATG16L1 complex transfers LC3 from ATG3 to PE	yes	reactome/R-HSA-5678490.md	ATG16L1 complex transfers LC3 from ATG3 to PE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization during LC3 lipidation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	72	R-HSA-5679255	WIPI2 binds ATG12:ATG5:ATG16L	yes	reactome/R-HSA-5679255.md	WIPI2 binds ATG12:ATG5:ATG16L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	73	R-HSA-5682010	ATG10:ATG12 binds ATG5	yes	reactome/R-HSA-5682010.md	ATG10:ATG12 binds ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	74	R-HSA-5682012	ATG5:ATG12 binds ATG16L1	yes	reactome/R-HSA-5682012.md	ATG5:ATG12 binds ATG16L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	75	R-HSA-5682690	ATG10 dissociates from ATG12:ATG5	yes	reactome/R-HSA-5682690.md	ATG10 dissociates from ATG12:ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	76	R-HSA-5683588	ATG10 transfers ATG12 from ATG10 to ATG5	yes	reactome/R-HSA-5683588.md	ATG10 transfers ATG12 from ATG10 to ATG5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG5	genes/human/ATG5/ATG5-ai-review.yaml	ATG5	Q9H1Y0	NCBITaxon:9606	Homo sapiens	77	R-HSA-9936620	ATG5:ATG12 binds ATG16L2	yes	reactome/R-HSA-9936620.md	ATG5:ATG12 binds ATG16L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	41	R-HSA-5681981	ATG3 transfers LC3 from ATG7 to ATG3	yes	reactome/R-HSA-5681981.md	ATG3 transfers LC3 from ATG7 to ATG3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for ATG3 transferring LC3 from ATG7.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	42	R-HSA-5682011	LC3 binds ATG7 dimer	yes	reactome/R-HSA-5682011.md	LC3 binds ATG7 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for LC3 binding ATG7 dimer.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	43	R-HSA-5682896	LC3:ATG7 dimer binds ATG3	yes	reactome/R-HSA-5682896.md	LC3:ATG7 dimer binds ATG3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for LC3:ATG7 dimer binding ATG3.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	44	R-HSA-9020616	ATG12 forms a thioester bond with ATG7 dimer	yes	reactome/R-HSA-9020616.md	ATG12 forms a thioester bond with ATG7 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for ATG12 forming thioester with ATG7 dimer.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	54	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome for secretory granule exocytosis. ATG7 detected in secretory granule lumen which can be released extracellularly.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	55	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome for ficolin-1-rich granule exocytosis.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	56	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS for secretory granule lumen localization.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	57	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS for ficolin-1-rich granule lumen localization in neutrophils.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	65	R-HSA-5681980	ATG12 binds ATG7 dimer	yes	reactome/R-HSA-5681980.md	ATG12 binds ATG7 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for ATG12 binding ATG7 dimer in cytosol.
human	ATG7	genes/human/ATG7/ATG7-ai-review.yaml	ATG7	O95352	NCBITaxon:9606	Homo sapiens	66	R-HSA-5683593	ATG7:ATG3:LC3 dissociates	yes	reactome/R-HSA-5683593.md	ATG7:ATG3:LC3 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for ATG7:ATG3:LC3 complex dissociation.
human	ATG9A	genes/human/ATG9A/ATG9A-ai-review.yaml	ATG9A	Q7Z3C6	NCBITaxon:9606	Homo sapiens	58	R-HSA-9840807	OPTN binds ATG9A	yes	reactome/R-HSA-9840807.md	OPTN binds ATG9A	Homo sapiens	GO:0034045	phagophore assembly site membrane	TAS	located_in	CC	false		MODIFY	Phagophore assembly site membrane: the evidence describes ATG9A on the phagophore itself, not on a membrane bounding the assembly site.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	24	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation. Consistent with the established cytosolic localization of ATIC, though attached to an ALK-fusion signaling event module (see reference).
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	25	R-HSA-9700190	ALK mutants bind SHC	yes	reactome/R-HSA-9700190.md	ALK mutants bind SHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	26	R-HSA-9700193	ALK mutants phosphorylate SHC1	yes	reactome/R-HSA-9700193.md	ALK mutants phosphorylate SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	27	R-HSA-9710914	ALK fusions bind GRB2	yes	reactome/R-HSA-9710914.md	ALK fusions bind GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	28	R-HSA-9710917	ALK fusion proteins bind PLCG1	yes	reactome/R-HSA-9710917.md	ALK fusion proteins bind PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	29	R-HSA-9712086	ALK fusions phosphorylate PLCG1	yes	reactome/R-HSA-9712086.md	ALK fusions phosphorylate PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	30	R-HSA-9724099	ALK mutants:p-3Y SHC binds GRB2	yes	reactome/R-HSA-9724099.md	ALK mutants:p-3Y SHC binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	40	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization annotation (ALK-fusion module). Consistent with ATIC's cytosolic localization.
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	46	R-HSA-73797	FAICAR => IMP + H2O	yes	reactome/R-HSA-73797.md	FAICAR => IMP + H2O	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome cytosol localization for the reaction ""FAICAR => IMP + H2O"" (the IMP cyclohydrolase step). This correctly places ATIC's catalytic activity in the cytosol."
human	ATIC	genes/human/ATIC/ATIC-ai-review.yaml	ATIC	P31939	NCBITaxon:9606	Homo sapiens	47	R-HSA-73798	AICAR + 10-Formyl-THF => FAICAR + THF	yes	reactome/R-HSA-73798.md	AICAR + 10-Formyl-THF => FAICAR + THF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome cytosol localization for the reaction ""AICAR + 10-Formyl-THF => FAICAR + THF"" (the AICAR transformylase step). Correctly places ATIC's catalytic activity in the cytosol."
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	37	R-HSA-3371567	DBC1 is phosphorylated by ATM/ART	yes	reactome/R-HSA-3371567.md	DBC1 is phosphorylated by ATM/ART	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	38	R-HSA-349444	Phosphorylation of COP1 at Ser-387 by ATM	yes	reactome/R-HSA-349444.md	Phosphorylation of COP1 at Ser-387 by ATM	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	39	R-HSA-349455	Phosphorylation of MDM4 by ATM	yes	reactome/R-HSA-349455.md	Phosphorylation of MDM4 by ATM	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	40	R-HSA-5682598	ATM phosphorylates HERC2	yes	reactome/R-HSA-5682598.md	ATM phosphorylates HERC2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	41	R-HSA-5682983	ATM phosphorylates WHSC1	yes	reactome/R-HSA-5682983.md	ATM phosphorylates WHSC1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	42	R-HSA-5683425	ATM phosphorylates TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5683425.md	ATM phosphorylates TP53BP1 at DNA DSBs	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	43	R-HSA-5683964	ATM phosphorylates EYA1-4	yes	reactome/R-HSA-5683964.md	ATM phosphorylates EYA1-4	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	44	R-HSA-5684140	ATM phosphorylates RBBP8	yes	reactome/R-HSA-5684140.md	ATM phosphorylates RBBP8	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	45	R-HSA-5686578	Activated ATM phosphorylates ABL1	yes	reactome/R-HSA-5686578.md	Activated ATM phosphorylates ABL1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	46	R-HSA-5686704	Activated ATM phosphorylates DCLRE1C	yes	reactome/R-HSA-5686704.md	Activated ATM phosphorylates DCLRE1C	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	47	R-HSA-5693536	ATM phosphorylates MDC1	yes	reactome/R-HSA-5693536.md	ATM phosphorylates MDC1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	48	R-HSA-5693549	ATM phosphorylates histone H2AFX on S139 at DNA DSBs	yes	reactome/R-HSA-5693549.md	ATM phosphorylates histone H2AFX on S139 at DNA DSBs	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	49	R-HSA-5693551	Phosphorylation of BRCA1-A complex at multiple sites by ATM	yes	reactome/R-HSA-5693551.md	Phosphorylation of BRCA1-A complex at multiple sites by ATM	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	50	R-HSA-5693598	ATM phosphorylates NBN	yes	reactome/R-HSA-5693598.md	ATM phosphorylates NBN	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	51	R-HSA-5693609	ATM phosphorylates TP53 at S15	yes	reactome/R-HSA-5693609.md	ATM phosphorylates TP53 at S15	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	52	R-HSA-6798372	ATM phosphorylates DYRK2	yes	reactome/R-HSA-6798372.md	ATM phosphorylates DYRK2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain source-supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	53	R-HSA-6799097	ATM phosphorylates ZNF420	yes	reactome/R-HSA-6799097.md	ATM phosphorylates ZNF420	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain source-supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	54	R-HSA-6800490	ATM phosphorylates PIDD1	yes	reactome/R-HSA-6800490.md	ATM phosphorylates PIDD1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain source-supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	55	R-HSA-6804276	ATM phosphorylates TTC5	yes	reactome/R-HSA-6804276.md	ATM phosphorylates TTC5	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain source-supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	56	R-HSA-6804955	ATM phosphorylates MDM2	yes	reactome/R-HSA-6804955.md	ATM phosphorylates MDM2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain source-supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	57	R-HSA-69891	Phosphorylation and activation of CHEK2 by ATM	yes	reactome/R-HSA-69891.md	Phosphorylation and activation of CHEK2 by ATM	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Retain supported protein serine/threonine kinase activity.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	102	R-HSA-3371567	DBC1 is phosphorylated by ATM/ART	yes	reactome/R-HSA-3371567.md	DBC1 is phosphorylated by ATM/ART	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	103	R-HSA-349444	Phosphorylation of COP1 at Ser-387 by ATM	yes	reactome/R-HSA-349444.md	Phosphorylation of COP1 at Ser-387 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	104	R-HSA-349455	Phosphorylation of MDM4 by ATM	yes	reactome/R-HSA-349455.md	Phosphorylation of MDM4 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	105	R-HSA-5682018	MRN complex bound to shortened telomeres recruits ATM	yes	reactome/R-HSA-5682018.md	MRN complex bound to shortened telomeres recruits ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	106	R-HSA-5682026	MRN bound to shortened telomeres activates ATM	yes	reactome/R-HSA-5682026.md	MRN bound to shortened telomeres activates ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	107	R-HSA-5682044	KAT5 acetylates ATM at DNA DSBs	yes	reactome/R-HSA-5682044.md	KAT5 acetylates ATM at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	108	R-HSA-5682586	HERC2 and PIAS4 are recruited to DNA DSBs	yes	reactome/R-HSA-5682586.md	HERC2 and PIAS4 are recruited to DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	109	R-HSA-5682588	RNF8 binds phosphorylated MDC1 at DNA DSBs	yes	reactome/R-HSA-5682588.md	RNF8 binds phosphorylated MDC1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	110	R-HSA-5682598	ATM phosphorylates HERC2	yes	reactome/R-HSA-5682598.md	ATM phosphorylates HERC2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	111	R-HSA-5682607	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs	yes	reactome/R-HSA-5682607.md	PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	112	R-HSA-5682629	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8	yes	reactome/R-HSA-5682629.md	HERC2 facilitates UBE2N:UBE2V2 binding to RNF8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	113	R-HSA-5682858	RNF8 and RNF168 ubiquitinate H2AFX	yes	reactome/R-HSA-5682858.md	RNF8 and RNF168 ubiquitinate H2AFX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	114	R-HSA-5682863	RNF168 binds DNA DSBs	yes	reactome/R-HSA-5682863.md	RNF168 binds DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	115	R-HSA-5682965	WHSC1 dimethylates histone H4 on lysine K21 at DSBs	yes	reactome/R-HSA-5682965.md	WHSC1 dimethylates histone H4 on lysine K21 at DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	116	R-HSA-5682967	WHSC1 binds DNA DSBs	yes	reactome/R-HSA-5682967.md	WHSC1 binds DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	117	R-HSA-5682983	ATM phosphorylates WHSC1	yes	reactome/R-HSA-5682983.md	ATM phosphorylates WHSC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	118	R-HSA-5682992	KDM4A,B bind H4K20Me2	yes	reactome/R-HSA-5682992.md	KDM4A,B bind H4K20Me2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	119	R-HSA-5683077	RNF8 and RNF168 ubiquitinate KDM4A,B	yes	reactome/R-HSA-5683077.md	RNF8 and RNF168 ubiquitinate KDM4A,B	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	120	R-HSA-5683384	UIMC1 and FAM175A bind DNA DSBs	yes	reactome/R-HSA-5683384.md	UIMC1 and FAM175A bind DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	121	R-HSA-5683385	Formation of BRCA1-A complex at DNA DSBs	yes	reactome/R-HSA-5683385.md	Formation of BRCA1-A complex at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	122	R-HSA-5683405	PPP5C dephosphorylates TP53BP1	yes	reactome/R-HSA-5683405.md	PPP5C dephosphorylates TP53BP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	123	R-HSA-5683425	ATM phosphorylates TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5683425.md	ATM phosphorylates TP53BP1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	124	R-HSA-5683735	CHEK2 is recruited to DNA DSBs	yes	reactome/R-HSA-5683735.md	CHEK2 is recruited to DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	125	R-HSA-5683801	CHEK2 phosphorylates BRCA1	yes	reactome/R-HSA-5683801.md	CHEK2 phosphorylates BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	126	R-HSA-5683964	ATM phosphorylates EYA1-4	yes	reactome/R-HSA-5683964.md	ATM phosphorylates EYA1-4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	127	R-HSA-5683967	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX	yes	reactome/R-HSA-5683967.md	EYA1-4 dephosphorylates tyrosine Y142 of H2AFX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	128	R-HSA-5683986	APBB1 and MAPK8 bind diphosphorylated H2AFX	yes	reactome/R-HSA-5683986.md	APBB1 and MAPK8 bind diphosphorylated H2AFX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	129	R-HSA-5684052	PIAS4 SUMOylates MDC1	yes	reactome/R-HSA-5684052.md	PIAS4 SUMOylates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	130	R-HSA-5684071	RNF4 ubiquitinates MDC1	yes	reactome/R-HSA-5684071.md	RNF4 ubiquitinates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	131	R-HSA-5684081	MRN complex binds CDK2 and RBBP8	yes	reactome/R-HSA-5684081.md	MRN complex binds CDK2 and RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	132	R-HSA-5684096	CDK2 phosphorylates RBBP8	yes	reactome/R-HSA-5684096.md	CDK2 phosphorylates RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	133	R-HSA-5684108	BRCA1 binds phosphorylated RBBP8	yes	reactome/R-HSA-5684108.md	BRCA1 binds phosphorylated RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	134	R-HSA-5684140	ATM phosphorylates RBBP8	yes	reactome/R-HSA-5684140.md	ATM phosphorylates RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	135	R-HSA-5684875	Binding of ATR:ATRIP to RPA at resected DNA DSBs	yes	reactome/R-HSA-5684875.md	Binding of ATR:ATRIP to RPA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	136	R-HSA-5684882	CHEK1 is recruited to resected DNA DSBs	yes	reactome/R-HSA-5684882.md	CHEK1 is recruited to resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	137	R-HSA-5684887	Activation of CHEK1 at resected DNA DSBs	yes	reactome/R-HSA-5684887.md	Activation of CHEK1 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	138	R-HSA-5685011	ATR activation at DNA DSBs	yes	reactome/R-HSA-5685011.md	ATR activation at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	139	R-HSA-5685156	ATR phosphorylates RPA2	yes	reactome/R-HSA-5685156.md	ATR phosphorylates RPA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	140	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	141	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	142	R-HSA-5685985	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	yes	reactome/R-HSA-5685985.md	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	143	R-HSA-5685994	Long-range resection of DNA DSBs by EXO1 or DNA2	yes	reactome/R-HSA-5685994.md	Long-range resection of DNA DSBs by EXO1 or DNA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	144	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	145	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	146	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	147	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	148	R-HSA-5686578	Activated ATM phosphorylates ABL1	yes	reactome/R-HSA-5686578.md	Activated ATM phosphorylates ABL1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	149	R-HSA-5686642	RAD52 promotes single strand annealing at resected DNA DSBs	yes	reactome/R-HSA-5686642.md	RAD52 promotes single strand annealing at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	150	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	151	R-HSA-5686663	Completion of SSA	yes	reactome/R-HSA-5686663.md	Completion of SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	152	R-HSA-5686685	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5686685.md	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	153	R-HSA-5686704	Activated ATM phosphorylates DCLRE1C	yes	reactome/R-HSA-5686704.md	Activated ATM phosphorylates DCLRE1C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	154	R-HSA-5686900	TP53BP1 recruits DCLRE1C to ATM	yes	reactome/R-HSA-5686900.md	TP53BP1 recruits DCLRE1C to ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	155	R-HSA-5693536	ATM phosphorylates MDC1	yes	reactome/R-HSA-5693536.md	ATM phosphorylates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	156	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	157	R-HSA-5693540	MRN activates ATM	yes	reactome/R-HSA-5693540.md	MRN activates ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	158	R-HSA-5693542	Association of RPA complexes with ssDNA at resected DNA DSBs	yes	reactome/R-HSA-5693542.md	Association of RPA complexes with ssDNA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	159	R-HSA-5693549	ATM phosphorylates histone H2AFX on S139 at DNA DSBs	yes	reactome/R-HSA-5693549.md	ATM phosphorylates histone H2AFX on S139 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	160	R-HSA-5693551	Phosphorylation of BRCA1-A complex at multiple sites by ATM	yes	reactome/R-HSA-5693551.md	Phosphorylation of BRCA1-A complex at multiple sites by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	161	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	162	R-HSA-5693564	Association of RAD51 with RAD52:DNA double-strand break ends	yes	reactome/R-HSA-5693564.md	Association of RAD51 with RAD52:DNA double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	163	R-HSA-5693566	TP53BP1 associates with H4K20Me2 at DNA DSBs	yes	reactome/R-HSA-5693566.md	TP53BP1 associates with H4K20Me2 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	164	R-HSA-5693580	Association of RAD52 with the RPA complex at resected DNA DSBs	yes	reactome/R-HSA-5693580.md	Association of RAD52 with the RPA complex at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	165	R-HSA-5693583	MDC1 associates with gamma-H2AFX at nuclear foci	yes	reactome/R-HSA-5693583.md	MDC1 associates with gamma-H2AFX at nuclear foci	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	166	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	167	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	168	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	169	R-HSA-5693598	ATM phosphorylates NBN	yes	reactome/R-HSA-5693598.md	ATM phosphorylates NBN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	170	R-HSA-5693599	Association of Ku heterodimer with ends of DNA double-strand break	yes	reactome/R-HSA-5693599.md	Association of Ku heterodimer with ends of DNA double-strand break	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	171	R-HSA-5693602	ATM recognizes H2AFX-Nucleosomes	yes	reactome/R-HSA-5693602.md	ATM recognizes H2AFX-Nucleosomes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	172	R-HSA-5693608	Initial resection of double-strand break ends	yes	reactome/R-HSA-5693608.md	Initial resection of double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	173	R-HSA-5693609	ATM phosphorylates TP53 at S15	yes	reactome/R-HSA-5693609.md	ATM phosphorylates TP53 at S15	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	174	R-HSA-5693612	MRN complex bound to DNA ends recruits ATM	yes	reactome/R-HSA-5693612.md	MRN complex bound to DNA ends recruits ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	175	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	176	R-HSA-6792712	KAT5 acetylates ATM at shortened telomeres	yes	reactome/R-HSA-6792712.md	KAT5 acetylates ATM at shortened telomeres	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	177	R-HSA-6798372	ATM phosphorylates DYRK2	yes	reactome/R-HSA-6798372.md	ATM phosphorylates DYRK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	178	R-HSA-6799097	ATM phosphorylates ZNF420	yes	reactome/R-HSA-6799097.md	ATM phosphorylates ZNF420	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	179	R-HSA-6799332	ATR phosphorylates TP53	yes	reactome/R-HSA-6799332.md	ATR phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	180	R-HSA-6800490	ATM phosphorylates PIDD1	yes	reactome/R-HSA-6800490.md	ATM phosphorylates PIDD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	181	R-HSA-6804276	ATM phosphorylates TTC5	yes	reactome/R-HSA-6804276.md	ATM phosphorylates TTC5	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	182	R-HSA-6804955	ATM phosphorylates MDM2	yes	reactome/R-HSA-6804955.md	ATM phosphorylates MDM2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain source-supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	183	R-HSA-69891	Phosphorylation and activation of CHEK2 by ATM	yes	reactome/R-HSA-69891.md	Phosphorylation and activation of CHEK2 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	184	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	185	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	186	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	187	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	188	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	189	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	190	R-HSA-9980006	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	yes	reactome/R-HSA-9980006.md	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	191	R-HSA-9980021	LIG1 binds SSA sites	yes	reactome/R-HSA-9980021.md	LIG1 binds SSA sites	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Retain supported nucleoplasm.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	199	R-HSA-9664855	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664855.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	200	R-HSA-9664862	ATM dimer:PEX5 phosphorylates PEX5	yes	reactome/R-HSA-9664862.md	ATM dimer:PEX5 phosphorylates PEX5	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	201	R-HSA-9664879	ATM:PEX5 binds ATM	yes	reactome/R-HSA-9664879.md	ATM:PEX5 binds ATM	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	202	R-HSA-9664880	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	yes	reactome/R-HSA-9664880.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	203	R-HSA-9664881	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664881.md	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	204	R-HSA-9664883	ATM:PEX5 translocates from cytosol to peroxisomal membrane	yes	reactome/R-HSA-9664883.md	ATM:PEX5 translocates from cytosol to peroxisomal membrane	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	205	R-HSA-9664888	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9664888.md	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	206	R-HSA-9664892	SQSTM1 binds ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9664892.md	SQSTM1 binds ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	207	R-HSA-9674127	USP30 deubiquitinates ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9674127.md	USP30 deubiquitinates ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	208	R-HSA-9674131	USP30 binds ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9674131.md	USP30 binds ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		MODIFY	Retain peroxisomal association with membrane rather than matrix placement.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	212	R-HSA-9664850	ATM binds PEX5	yes	reactome/R-HSA-9664850.md	ATM binds PEX5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosol as a contextual function or association.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	213	R-HSA-9664883	ATM:PEX5 translocates from cytosol to peroxisomal membrane	yes	reactome/R-HSA-9664883.md	ATM:PEX5 translocates from cytosol to peroxisomal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosol as a contextual function or association.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	217	R-HSA-5693606	DNA Double Strand Break Response	yes	reactome/R-HSA-5693606.md	DNA Double Strand Break Response	Homo sapiens	GO:0006302	double-strand break repair	TAS	involved_in	BP	false		ACCEPT	Retain supported double-strand break repair.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	218	R-HSA-5693571	Nonhomologous End-Joining (NHEJ)	yes	reactome/R-HSA-5693571.md	Nonhomologous End-Joining (NHEJ)	Homo sapiens	GO:0006303	double-strand break repair via nonhomologous end joining	TAS	involved_in	BP	false		ACCEPT	Retain supported double-strand break repair via nonhomologous end joining.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	247	R-HSA-69563	p53-Dependent G1 DNA Damage Response	yes	reactome/R-HSA-69563.md	p53-Dependent G1 DNA Damage Response	Homo sapiens	GO:0030330	DNA damage response, signal transduction by p53 class mediator	TAS	involved_in	BP	false		ACCEPT	Retain supported DNA damage response, signal transduction by p53 class mediator.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	268	R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes	yes	reactome/R-HSA-5633008.md	TP53 Regulates Transcription of Cell Death Genes	Homo sapiens	GO:0042981	regulation of apoptotic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Retain regulation of apoptotic process as a contextual function or association.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	289	R-HSA-2559583	Cellular Senescence	yes	reactome/R-HSA-2559583.md	Cellular Senescence	Homo sapiens	GO:0090398	cellular senescence	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Retain cellular senescence as a contextual function or association.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	307	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		UNDECIDED	The source-specific regulation of cellular response to heat assertion remains unresolved.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	309	R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	yes	reactome/R-HSA-6804756.md	Regulation of TP53 Activity through Phosphorylation	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		ACCEPT	Retain supported regulation of signal transduction by p53 class mediator.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	310	R-HSA-6804760	Regulation of TP53 Activity through Methylation	yes	reactome/R-HSA-6804760.md	Regulation of TP53 Activity through Methylation	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		ACCEPT	Retain supported regulation of signal transduction by p53 class mediator.
human	ATM	genes/human/ATM/ATM-ai-review.yaml	ATM	Q13315	NCBITaxon:9606	Homo sapiens	311	R-HSA-6806003	Regulation of TP53 Expression and Degradation	yes	reactome/R-HSA-6806003.md	Regulation of TP53 Expression and Degradation	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		ACCEPT	Retain supported regulation of signal transduction by p53 class mediator.
human	ATP13A1	genes/human/ATP13A1/ATP13A1-ai-review.yaml	ATP13A1	Q9HD20	NCBITaxon:9606	Homo sapiens	20	R-HSA-936837	Ion transport by P-type ATPases	yes	reactome/R-HSA-936837.md	Ion transport by P-type ATPases	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		REMOVE	Direct manganese/cation translocation is not supported by the P5A substrate mechanism.
human	ATP13A1	genes/human/ATP13A1/ATP13A1-ai-review.yaml	ATP13A1	Q9HD20	NCBITaxon:9606	Homo sapiens	21	R-HSA-5692462	ATP13A1 transports Mn2+ from cytosol to ER lumen	yes	reactome/R-HSA-5692462.md	ATP13A1 transports Mn2+ from cytosol to ER lumen	Homo sapiens	GO:0015410	ABC-type manganese transporter activity	TAS	enables	MF	false		REMOVE	ATP13A1 is a P-type ATPase, not an ABC-type manganese transporter.
human	ATP13A1	genes/human/ATP13A1/ATP13A1-ai-review.yaml	ATP13A1	Q9HD20	NCBITaxon:9606	Homo sapiens	28	R-HSA-5692462	ATP13A1 transports Mn2+ from cytosol to ER lumen	yes	reactome/R-HSA-5692462.md	ATP13A1 transports Mn2+ from cytosol to ER lumen	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The ER membrane location is correct, but the associated Reactome manganese-transport event should not be used for ATP13A1 molecular-function assertions.
human	ATP13A2	genes/human/ATP13A2/ATP13A2-ai-review.yaml	ATP13A2	Q9NQ11	NCBITaxon:9606	Homo sapiens	64	R-HSA-5692480	ATP13A2 transports cations from cytosol to lysosomal lumen	yes	reactome/R-HSA-5692480.md	ATP13A2 transports cations from cytosol to lysosomal lumen	Homo sapiens	GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Retain the reported potassium-associated transport activity as non-core.
human	ATP13A2	genes/human/ATP13A2/ATP13A2-ai-review.yaml	ATP13A2	Q9NQ11	NCBITaxon:9606	Homo sapiens	79	R-HSA-936837	Ion transport by P-type ATPases	yes	reactome/R-HSA-936837.md	Ion transport by P-type ATPases	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Retain the reported potassium-associated transport activity as non-core.
human	ATP13A2	genes/human/ATP13A2/ATP13A2-ai-review.yaml	ATP13A2	Q9NQ11	NCBITaxon:9606	Homo sapiens	87	R-HSA-5692480	ATP13A2 transports cations from cytosol to lysosomal lumen	yes	reactome/R-HSA-5692480.md	ATP13A2 transports cations from cytosol to lysosomal lumen	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		MODIFY	Correct the compartment or regulatory direction while preserving the source assertion.
human	ATP1A2	genes/human/ATP1A2/ATP1A2-ai-review.yaml	ATP1A2	P50993	NCBITaxon:9606	Homo sapiens	28	R-HSA-936897	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+	yes	reactome/R-HSA-936897.md	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome summary places the alpha/beta/FXYD sodium-potassium exchange complex at the plasma membrane.
human	ATP1A2	genes/human/ATP1A2/ATP1A2-ai-review.yaml	ATP1A2	P50993	NCBITaxon:9606	Homo sapiens	29	R-HSA-9684068	ATP1A:ATP1B:FXYD binds cardiac glycosides	yes	reactome/R-HSA-9684068.md	ATP1A:ATP1B:FXYD binds cardiac glycosides	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The glycoside-binding Reactome event concerns the plasma-membrane alpha/beta/FXYD pump.
human	ATP1A3	genes/human/ATP1A3/ATP1A3-ai-review.yaml	ATP1A3	P13637	NCBITaxon:9606	Homo sapiens	36	R-HSA-936897	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+	yes	reactome/R-HSA-936897.md	ATP1A:ATP1B:FXYD exchanges 3Na+ for 2K+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The complete R-HSA-936897 summary describes sodium-potassium exchange by the plasma-membrane ATP1A:ATP1B:FXYD complex.
human	ATP1A3	genes/human/ATP1A3/ATP1A3-ai-review.yaml	ATP1A3	P13637	NCBITaxon:9606	Homo sapiens	37	R-HSA-9684068	ATP1A:ATP1B:FXYD binds cardiac glycosides	yes	reactome/R-HSA-9684068.md	ATP1A:ATP1B:FXYD binds cardiac glycosides	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The complete R-HSA-9684068 summary describes cardiac-glycoside binding to the plasma-membrane ATP1A:ATP1B:FXYD complex.
human	ATP2B2	genes/human/ATP2B2/ATP2B2-ai-review.yaml	ATP2B2	Q01814	NCBITaxon:9606	Homo sapiens	7	R-HSA-418309	ATP2B1-4 transport cytosolic Ca2+ to extracellular region	yes	reactome/R-HSA-418309.md	ATP2B1-4 transport cytosolic Ca2+ to extracellular region	Homo sapiens	GO:0005388	P-type calcium transporter activity	TAS	enables	MF	false		ACCEPT	Reactome places PMCA2 among plasma-membrane calcium-exporting ATPases.
human	ATP2B2	genes/human/ATP2B2/ATP2B2-ai-review.yaml	ATP2B2	Q01814	NCBITaxon:9606	Homo sapiens	17	R-HSA-418309	ATP2B1-4 transport cytosolic Ca2+ to extracellular region	yes	reactome/R-HSA-418309.md	ATP2B1-4 transport cytosolic Ca2+ to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome calcium-export reaction places its ATP2B catalysts in the plasma membrane.
human	ATP2B2	genes/human/ATP2B2/ATP2B2-ai-review.yaml	ATP2B2	Q01814	NCBITaxon:9606	Homo sapiens	32	R-HSA-936837	Ion transport by P-type ATPases	yes	reactome/R-HSA-936837.md	Ion transport by P-type ATPases	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		ACCEPT	PMCA2 carries out the calcium-export step within the P-type ATPase pathway.
human	ATP2B2	genes/human/ATP2B2/ATP2B2-ai-review.yaml	ATP2B2	Q01814	NCBITaxon:9606	Homo sapiens	55	R-HSA-5578775	Ion homeostasis	yes	reactome/R-HSA-5578775.md	Ion homeostasis	Homo sapiens	GO:1903779	regulation of cardiac conduction	TAS	involved_in	BP	false		UNDECIDED	Reactome embeds a family calcium-export reaction in a cardiac pathway.
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	53	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""ATPase synthesizes ATP"". The F1 head where ATP5F1A resides faces the mitochondrial matrix."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	54	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""Enzyme-bound ATP is released"". Duplicate CC annotation from a different Reactome reaction. Correct."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	55	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""ADP and Pi bind to ATPase"". Duplicate CC annotation from a different Reactome reaction. Correct."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	56	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""F1Fo ATP synthase dimerizes"". The dimerization occurs at the inner mitochondrial membrane, with the F1 head in the matrix."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	57	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""CLPXP binds mitochondrial matrix proteins"". ATP5F1A is a substrate of CLPXP protease in the mitochondrial matrix."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	58	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""LONP1 degrades mitochondrial matrix proteins"". ATP5F1A is a substrate of LONP1 protease in the matrix."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	59	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""LONP1 binds mitochondrial matrix proteins"". Same context as above."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	60	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""CLPXP degrades mitochondrial matrix proteins""."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	61	R-HSA-9839105	AFG3L2 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9839105.md	AFG3L2 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""AFG3L2 degrades mitochondrial matrix proteins""."
human	ATP5F1A	genes/human/ATP5F1A/ATP5F1A-ai-review.yaml	ATP5F1A	P25705	NCBITaxon:9606	Homo sapiens	62	R-HSA-9839149	AFG3L2 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9839149.md	AFG3L2 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""AFG3L2 binds mitochondrial matrix proteins""."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	46	R-HSA-1592247	Expression of ATP5B	yes	reactome/R-HSA-1592247.md	Expression of ATP5B	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""Expression of ATP5B"". The F1 head containing the beta subunit faces the mitochondrial matrix."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	47	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""ATPase synthesizes ATP"". Correct localization for ATP synthesis at the matrix side."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	48	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""Enzyme-bound ATP is released""."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	49	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""ADP and Pi bind to ATPase""."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	50	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""F1Fo ATP synthase dimerizes"". The beta subunit is part of the complex that dimerizes."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	51	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""CLPXP binds mitochondrial matrix proteins"". ATP5F1B is a substrate for the CLPXP protease quality control system."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	52	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""LONP1 degrades mitochondrial matrix proteins""."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	53	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""LONP1 binds mitochondrial matrix proteins""."
human	ATP5F1B	genes/human/ATP5F1B/ATP5F1B-ai-review.yaml	ATP5F1B	P06576	NCBITaxon:9606	Homo sapiens	54	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for CC from Reactome pathway ""CLPXP degrades mitochondrial matrix proteins""."
human	ATP5F1D	genes/human/ATP5F1D/ATP5F1D-ai-review.yaml	ATP5F1D	P30049	NCBITaxon:9606	Homo sapiens	25	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix (ATPase synthesizes ATP reaction). Defensible because the F1 head projects into the matrix, but the curated primary location is the inner membrane.
human	ATP5F1D	genes/human/ATP5F1D/ATP5F1D-ai-review.yaml	ATP5F1D	P30049	NCBITaxon:9606	Homo sapiens	26	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix (Enzyme-bound ATP is released reaction). Same rationale as the other Reactome matrix annotations.
human	ATP5F1D	genes/human/ATP5F1D/ATP5F1D-ai-review.yaml	ATP5F1D	P30049	NCBITaxon:9606	Homo sapiens	27	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix (ADP and Pi bind to ATPase reaction). Same rationale as the other Reactome matrix annotations.
human	ATP5F1D	genes/human/ATP5F1D/ATP5F1D-ai-review.yaml	ATP5F1D	P30049	NCBITaxon:9606	Homo sapiens	28	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix (F1Fo ATP synthase dimerizes reaction). Same rationale as the other Reactome matrix annotations.
human	ATP5F1E	genes/human/ATP5F1E/ATP5F1E-ai-review.yaml	ATP5F1E	P56381	NCBITaxon:9606	Homo sapiens	19	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of epsilon to the mitochondrial matrix, reflecting that the F1 head (with the central stalk including epsilon) projects into the matrix.
human	ATP5F1E	genes/human/ATP5F1E/ATP5F1E-ai-review.yaml	ATP5F1E	P56381	NCBITaxon:9606	Homo sapiens	20	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) matrix localization associated with the ""Enzyme-bound ATP is released"" step of ATP synthesis. Reflects the matrix-facing F1/central-stalk position of epsilon."
human	ATP5F1E	genes/human/ATP5F1E/ATP5F1E-ai-review.yaml	ATP5F1E	P56381	NCBITaxon:9606	Homo sapiens	21	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) matrix localization associated with the ""ADP and Pi bind to ATPase"" step. Reflects the matrix-facing catalytic/central-stalk region of the complex."
human	ATP5F1E	genes/human/ATP5F1E/ATP5F1E-ai-review.yaml	ATP5F1E	P56381	NCBITaxon:9606	Homo sapiens	22	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) matrix localization associated with the ""F1Fo ATP synthase dimerizes"" step. Reflects the matrix-facing F1/central-stalk position of epsilon."
human	ATP5MC1	genes/human/ATP5MC1/ATP5MC1-ai-review.yaml	ATP5MC1	P05496	NCBITaxon:9606	Homo sapiens	25	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway 'ATPase synthesizes ATP' localizes ATP5MC1 to mitochondrial inner membrane.
human	ATP5MC1	genes/human/ATP5MC1/ATP5MC1-ai-review.yaml	ATP5MC1	P05496	NCBITaxon:9606	Homo sapiens	26	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway 'Enzyme-bound ATP is released' shows ATP synthase in inner membrane.
human	ATP5MC1	genes/human/ATP5MC1/ATP5MC1-ai-review.yaml	ATP5MC1	P05496	NCBITaxon:9606	Homo sapiens	27	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway 'ADP and Pi bind to ATPase' localizes complex to inner membrane.
human	ATP5MC1	genes/human/ATP5MC1/ATP5MC1-ai-review.yaml	ATP5MC1	P05496	NCBITaxon:9606	Homo sapiens	28	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway 'F1Fo ATP synthase dimerizes' shows dimerization occurs in inner membrane.
human	ATP5MC2	genes/human/ATP5MC2/ATP5MC2-ai-review.yaml	ATP5MC2	Q06055	NCBITaxon:9606	Homo sapiens	16	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC2	genes/human/ATP5MC2/ATP5MC2-ai-review.yaml	ATP5MC2	Q06055	NCBITaxon:9606	Homo sapiens	17	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC2	genes/human/ATP5MC2/ATP5MC2-ai-review.yaml	ATP5MC2	Q06055	NCBITaxon:9606	Homo sapiens	18	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC2	genes/human/ATP5MC2/ATP5MC2-ai-review.yaml	ATP5MC2	Q06055	NCBITaxon:9606	Homo sapiens	19	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC3	genes/human/ATP5MC3/ATP5MC3-ai-review.yaml	ATP5MC3	P48201	NCBITaxon:9606	Homo sapiens	16	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC3	genes/human/ATP5MC3/ATP5MC3-ai-review.yaml	ATP5MC3	P48201	NCBITaxon:9606	Homo sapiens	17	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC3	genes/human/ATP5MC3/ATP5MC3-ai-review.yaml	ATP5MC3	P48201	NCBITaxon:9606	Homo sapiens	18	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MC3	genes/human/ATP5MC3/ATP5MC3-ai-review.yaml	ATP5MC3	P48201	NCBITaxon:9606	Homo sapiens	19	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation confirming ATP synthase localization to mitochondrial inner membrane.
human	ATP5MD	genes/human/ATP5MD/ATP5MD-ai-review.yaml	ATP5MD	Q96IX5	NCBITaxon:9606	Homo sapiens	13	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author-statement (TAS) inner-membrane localization associated with the ""ATPase synthesizes ATP"" reaction of the F1Fo ATP synthase."
human	ATP5MD	genes/human/ATP5MD/ATP5MD-ai-review.yaml	ATP5MD	Q96IX5	NCBITaxon:9606	Homo sapiens	14	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS inner-membrane localization associated with the ""Enzyme-bound ATP is released"" reaction of the F1Fo ATP synthase."
human	ATP5MD	genes/human/ATP5MD/ATP5MD-ai-review.yaml	ATP5MD	Q96IX5	NCBITaxon:9606	Homo sapiens	15	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS inner-membrane localization associated with the ""ADP and Pi bind to ATPase"" reaction of the F1Fo ATP synthase."
human	ATP5MD	genes/human/ATP5MD/ATP5MD-ai-review.yaml	ATP5MD	Q96IX5	NCBITaxon:9606	Homo sapiens	16	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS inner-membrane localization associated with the ""F1Fo ATP synthase dimerizes"" reaction — directly relevant given ATP5MD's role in Complex V dimerization."
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	30	R-HSA-164832	ATPase synthesizes ATP	yes	reactome/R-HSA-164832.md	ATPase synthesizes ATP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (ATPase synthesizes ATP reaction). Correct core location.
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	31	R-HSA-164834	Enzyme-bound ATP is released	yes	reactome/R-HSA-164834.md	Enzyme-bound ATP is released	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (enzyme-bound ATP release reaction). Correct core location.
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	32	R-HSA-164840	ADP and Pi bind to ATPase	yes	reactome/R-HSA-164840.md	ADP and Pi bind to ATPase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (ADP and Pi binding reaction). Correct core location.
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	33	R-HSA-8949580	F1Fo ATP synthase dimerizes	yes	reactome/R-HSA-8949580.md	F1Fo ATP synthase dimerizes	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (F1Fo ATP synthase dimerization). Correct core location.
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	34	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (LONP1 binds inner-membrane proteins). Correct core location.
human	ATP5PO	genes/human/ATP5PO/ATP5PO-ai-review.yaml	ATP5PO	P48047	NCBITaxon:9606	Homo sapiens	35	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (LONP1 degrades inner-membrane proteins). Correct core location.
human	ATP6AP1	genes/human/ATP6AP1/ATP6AP1-ai-review.yaml	ATP6AP1	Q15904	NCBITaxon:9606	Homo sapiens	50	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane context for the Reactome ATP6AP1-binds-V-ATPase event.
human	ATP6AP1	genes/human/ATP6AP1/ATP6AP1-ai-review.yaml	ATP6AP1	Q15904	NCBITaxon:9606	Homo sapiens	51	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane for the Reactome endosome acidification event.
human	ATP6AP1	genes/human/ATP6AP1/ATP6AP1-ai-review.yaml	ATP6AP1	Q15904	NCBITaxon:9606	Homo sapiens	52	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane for transferrin-receptor endosome acidification context.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	46	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The official human Reactome ATP6AP2 entity R-HSA-6799717 is explicitly located in tertiary-granule membrane and belongs to the event's protein set.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	47	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Official human ATP6AP2 entity R-HSA-6800921 explicitly belongs to the ficolin-rich granule membrane set.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	56	R-HSA-2022403	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	yes	reactome/R-HSA-2022403.md	Renin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The original Reactome renin-receptor complex is at the plasma membrane, consistent with the directly demonstrated human receptor function.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	57	R-HSA-2065357	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))	yes	reactome/R-HSA-2065357.md	Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to AGT(25-35) (Angiotensin-(1-10))	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The prorenin-receptor Reactome event uses plasma-membrane ATP6AP2.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	58	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Official R-HSA-2022356 links ATP6AP2 at the plasma membrane to the tertiary-granule exocytosis output set.
human	ATP6AP2	genes/human/ATP6AP2/ATP6AP2-ai-review.yaml	ATP6AP2	O75787	NCBITaxon:9606	Homo sapiens	59	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Official R-HSA-2022356 links the same human ATP6AP2 plasma-membrane entity to the ficolin-rich exocytosis output set.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	26	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported specialized-cell localization. Reactome places V-ATPase-containing secretory vesicle membranes at the plasma membrane during degranulation.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	27	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported specialized neutrophil granule/plasma membrane context, but non-core.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	28	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported secretory granule membrane context for V-ATPase-containing vesicles, but non-core.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	29	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported ficolin-1-rich granule membrane context in neutrophil degranulation, but non-core.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	34	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported specialized phagocytic vesicle membrane context. V-ATPase acidifies phagosomes, but this is a cell-context-specific location.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	35	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Correct endosome membrane localization in a V-ATPase assembly/accessory-subunit pathway context.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	36	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Correct endosome membrane localization for endosome acidification.
human	ATP6V0A1	genes/human/ATP6V0A1/ATP6V0A1-ai-review.yaml	ATP6V0A1	Q93050	NCBITaxon:9606	Homo sapiens	37	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Correct endosome membrane localization in transferrin receptor endosome acidification.
human	ATP6V0A2	genes/human/ATP6V0A2/ATP6V0A2-ai-review.yaml	ATP6V0A2	Q9Y487	NCBITaxon:9606	Homo sapiens	26	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Phagocytic vesicle membrane localization is supported by Reactome V-ATPase phagosome acidification context but is a context-specific location rather than ATP6V0A2 core identity.
human	ATP6V0A2	genes/human/ATP6V0A2/ATP6V0A2-ai-review.yaml	ATP6V0A2	Q9Y487	NCBITaxon:9606	Homo sapiens	27	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome places ATP6V0A2-containing V-ATPase context at endosome membranes during ATP6AP1/V-ATPase binding and acidification-related events.
human	ATP6V0A2	genes/human/ATP6V0A2/ATP6V0A2-ai-review.yaml	ATP6V0A2	Q9Y487	NCBITaxon:9606	Homo sapiens	28	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Endosome membrane localization is supported by the Reactome endosome acidification event and direct early-endosome literature for the a2 isoform.
human	ATP6V0A2	genes/human/ATP6V0A2/ATP6V0A2-ai-review.yaml	ATP6V0A2	Q9Y487	NCBITaxon:9606	Homo sapiens	29	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Endosome membrane localization is supported by Reactome transferrin-receptor endosome acidification context and by direct literature on the a2 isoform in early endosomes.
human	ATP6V0A4	genes/human/ATP6V0A4/ATP6V0A4-ai-review.yaml	ATP6V0A4	Q9HBG4	NCBITaxon:9606	Homo sapiens	29	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Phagocytic vesicle membrane is a generic Reactome V-ATPase projection and is not well supported for ATP6V0A4 specifically.
human	ATP6V0A4	genes/human/ATP6V0A4/ATP6V0A4-ai-review.yaml	ATP6V0A4	Q9HBG4	NCBITaxon:9606	Homo sapiens	30	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endosome membrane is retained as a supported V-ATPase context but not the defining ATP6V0A4 localization.
human	ATP6V0A4	genes/human/ATP6V0A4/ATP6V0A4-ai-review.yaml	ATP6V0A4	Q9HBG4	NCBITaxon:9606	Homo sapiens	31	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endosome membrane is retained as a supported V-ATPase context but not the defining ATP6V0A4 localization.
human	ATP6V0A4	genes/human/ATP6V0A4/ATP6V0A4-ai-review.yaml	ATP6V0A4	Q9HBG4	NCBITaxon:9606	Homo sapiens	32	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endosome membrane is retained as a supported V-ATPase context but not the defining ATP6V0A4 localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	30	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	31	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	32	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	33	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	34	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	35	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	36	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	37	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	38	R-HSA-9858940	MITF-M-dependent ATP6V0B gene expression	yes	reactome/R-HSA-9858940.md	MITF-M-dependent ATP6V0B gene expression	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Accept lysosomal membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	40	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Keep this localization as a valid but non-core or context-specific site for V-ATPase complexes.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	41	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	42	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane as a supported V-ATPase membrane localization.
human	ATP6V0B	genes/human/ATP6V0B/ATP6V0B-ai-review.yaml	ATP6V0B	Q99437	NCBITaxon:9606	Homo sapiens	43	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Accept endosome membrane as a supported V-ATPase membrane localization.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	38	R-HSA-9639286	RRAGC,D GTP/GDP exchange	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RRAGC,D GTP/GDP exchange. V-ATPase on lysosomal membrane participates in mTORC1 regulation through Rag GTPase signaling.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	39	R-HSA-9640167	RRAGA,B GDP/GTP exchange	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RRAGA,B GDP/GTP exchange. Related to mTORC1 signaling.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	40	R-HSA-9640168	V-ATPase Ragulator Rag complex dissociation with SLC38A9	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for V-ATPase:Ragulator:Rag complex dissociation with SLC38A9.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	41	R-HSA-9640175	V-ATPase Ragulator Rag binding to SLC38A9 Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for V-ATPase:Ragulator:Rag binding to SLC38A9:Arginine.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	42	R-HSA-9640195	RRAGA,B GTP hydrolysis	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RRAGA,B GTP hydrolysis.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	43	R-HSA-9645598	RRAGC,D GTP hydrolysis	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RRAGC,D GTP hydrolysis.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	44	R-HSA-9645608	V-ATPase Ragulator Rag binding to mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for V-ATPase:Ragulator:Rag binding to mTORC1.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	45	R-HSA-9646468	mTORC1 binding to RHEB GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for mTORC1 binding to RHEB:GTP.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	46	R-HSA-9858913	MITF-M-dependent ATP6V0C gene expression	yes	reactome/R-HSA-9858913.md	MITF-M-dependent ATP6V0C gene expression	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for MITF-M-dependent ATP6V0C gene expression.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	47	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for exocytosis of azurophil granule membrane proteins. V-ATPase components are present on neutrophil granule membranes and reach plasma membrane upon degranulation.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	48	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for exocytosis of tertiary granule membrane proteins.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	49	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for exocytosis of ficolin-rich granule membrane proteins.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	50	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		ACCEPT	V-ATPase is present on azurophil (primary) granule membranes in neutrophils.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	51	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		ACCEPT	V-ATPase is present on tertiary granule membranes in neutrophils.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	52	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		ACCEPT	V-ATPase is present on ficolin-1-rich granule membranes.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	60	R-HSA-1222516	Phagosomal pH reduction	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for phagosomal pH reduction. V-ATPase acidifies phagosomes for microbial killing.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	61	R-HSA-5252133	ATP6AP1 binding to V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for ATP6AP1 binding to V-ATPase. ATP6AP1 is an accessory subunit that helps assemble V-ATPase on endosomal membranes.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	62	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for endosome acidification.
human	ATP6V0C	genes/human/ATP6V0C/ATP6V0C-ai-review.yaml	ATP6V0C	P27449	NCBITaxon:9606	Homo sapiens	63	R-HSA-917841	Acidification of transferrin transferrin receptor containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for acidification of transferrin:transferrin receptor containing endosome.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	32	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	33	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	34	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	35	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	36	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	37	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	38	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	39	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	40	R-HSA-9858932	MITF-M-dependent ATP6V0D1 gene expression	yes	reactome/R-HSA-9858932.md	MITF-M-dependent ATP6V0D1 gene expression	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: lysosomal membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	51	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Context-specific vesicle membrane localization for V-ATPase: phagocytic vesicle membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	52	R-HSA-1791184	Expression of ATP6VOD1	yes	reactome/R-HSA-1791184.md	Expression of ATP6VOD1	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: endosome membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	53	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: endosome membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	54	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: endosome membrane.
human	ATP6V0D1	genes/human/ATP6V0D1/ATP6V0D1-ai-review.yaml	ATP6V0D1	P61421	NCBITaxon:9606	Homo sapiens	55	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Supported endolysosomal V-ATPase location: endosome membrane.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	17	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome places ATP6V0D2-containing V-ATPase events at the lysosomal membrane. The lysosomal interpretation is also consistent with ccRCC evidence that ATP6V0D2 increases lysosomal acidification/activity during autophagic degradation [PMID:39477683].
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	18	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome pathway (RRAG GTP exchange). Same evidence and rationale as above.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	19	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome (V-ATPase:Ragulator complex).
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	20	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome pathway.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	21	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome pathway.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	22	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome pathway.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	23	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome (mTORC1 signaling).
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	24	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Duplicate lysosomal membrane annotation from Reactome pathway.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	28	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"From Reactome pathway ""Intraphagosomal pH is lowered to 5 by V-ATPase"". V-ATPases including ATP6V0D2 function in phagosome acidification. This is consistent with d2's role in osteoclasts (which have specialized phagocytic activity) and macrophages."
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	29	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	From Reactome pathway showing ATP6AP1 binding to V-ATPase. Endosome membrane localization is consistent with V-ATPase function in endosomal acidification.
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	30	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"From Reactome pathway ""Endosome acidification"". Core function of V-ATPase."
human	ATP6V0D2	genes/human/ATP6V0D2/ATP6V0D2-ai-review.yaml	ATP6V0D2	Q8N8Y2	NCBITaxon:9606	Homo sapiens	31	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"From Reactome pathway ""Acidification of Tf:TfR1 containing endosome"". V-ATPases acidify endosomes containing transferrin receptor."
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	8	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane localization; consistent with V0 component localization.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	9	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	10	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	11	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	12	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	13	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	14	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	15	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	16	R-HSA-9858941	MITF-M-dependent ATP6V0E1 gene expression	yes	reactome/R-HSA-9858941.md	MITF-M-dependent ATP6V0E1 gene expression	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal membrane in MITF-dependent lysosome biogenesis context; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	20	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for phagocytic vesicle membrane (intraphagosomal pH lowering context); consistent with V0 domain at phagocytic vesicles in immune cells.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	21	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for endosome membrane; consistent with V0 component at endosomal membranes where V-ATPase acidifies endosomes.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	22	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for endosome membrane in endosome acidification context; consistent.
human	ATP6V0E1	genes/human/ATP6V0E1/ATP6V0E1-ai-review.yaml	ATP6V0E1	O15342	NCBITaxon:9606	Homo sapiens	23	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for endosome membrane in transferrin acidification context; consistent.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	11	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-context annotation placing the V-ATPase (and thus e2) on the lysosomal membrane during amino-acid/mTORC1 signaling reactions. Localization is correct; the specific reaction context is mTORC1 signaling rather than an e2-specific role.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	12	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation to lysosomal membrane in the context of mTORC1 amino-acid sensing. Correct compartment, complex-level/reaction context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	13	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization from an mTORC1/Ragulator dissociation reaction. Correct compartment for the V-ATPase complex.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	14	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization (V-ATPase:Ragulator binding SLC38A9:Arginine reaction). Correct compartment, signaling context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	15	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization (RRAGA,B GTP hydrolysis reaction). Correct compartment, signaling context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	16	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization (RRAGC,D GTP hydrolysis reaction). Correct compartment, signaling context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	17	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization (V-ATPase:Ragulator binding mTORC1 reaction). Correct compartment, signaling context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	18	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome lysosomal membrane localization (mTORC1 binding RHEB:GTP reaction). Correct compartment, signaling context.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	22	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing the V-ATPase on the phagosome membrane during intraphagosomal acidification. Correct compartment for the complex; not an e2-specific function.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	23	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing the V-ATPase on the endosome membrane (ATP6AP1 binds V-ATPase reaction). Correct compartment for the complex.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	24	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation to endosome membrane in the context of endosome acidification. Correct compartment for the V-ATPase complex.
human	ATP6V0E2	genes/human/ATP6V0E2/ATP6V0E2-ai-review.yaml	ATP6V0E2	Q8NHE4	NCBITaxon:9606	Homo sapiens	25	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation to endosome membrane (acidification of Tf:TfR1 endosome). Correct compartment for the V-ATPase complex.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	60	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Multiple Reactome TAS annotations for cytosol reflect V-ATPase participation in various Reactome pathway reactions.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	61	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	62	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	63	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	64	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in context of mTOR/Rag GTPase pathway.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	65	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in context of mTOR pathway.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	66	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	67	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	68	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	69	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	70	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in context of mTORC1 recruitment.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	71	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1A	genes/human/ATP6V1A/ATP6V1A-ai-review.yaml	ATP6V1A	P38606	NCBITaxon:9606	Homo sapiens	72	R-HSA-9858928	MITF-M-dependent ATP6V1A gene expression	yes	reactome/R-HSA-9858928.md	MITF-M-dependent ATP6V1A gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in context of MITF-M regulation of ATP6V1A.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	45	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the phagosomal-acidification event’s cytosolic context.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	46	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for ATP6AP1–V-ATPase association.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	47	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the endosome-acidification event’s cytosolic context.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	48	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for the transferrin-endosome event.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	49	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for RagC/D nucleotide exchange.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	50	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for RagA/B nucleotide exchange.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	51	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for SLC38A9 dissociation.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	52	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for SLC38A9 association.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	53	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for RagA/B GTP hydrolysis.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	54	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for RagC/D GTP hydrolysis.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	55	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for mTORC1 recruitment.
human	ATP6V1B1	genes/human/ATP6V1B1/ATP6V1B1-ai-review.yaml	ATP6V1B1	P15313	NCBITaxon:9606	Homo sapiens	56	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain cytosolic context for RHEB–mTORC1 association.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	35	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosolic V-ATPase. Reflects V1 domain dissociation.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	36	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	37	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	38	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	39	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in mTOR/Rag GTPase pathway context.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	40	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	41	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	42	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	43	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	44	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	45	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in mTORC1 recruitment context.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	46	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1B2	genes/human/ATP6V1B2/ATP6V1B2-ai-review.yaml	ATP6V1B2	P21281	NCBITaxon:9606	Homo sapiens	47	R-HSA-9858918	MITF-M-dependent ATP6V1B2 gene expression	yes	reactome/R-HSA-9858918.md	MITF-M-dependent ATP6V1B2 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in MITF-M-dependent ATP6V1B2 gene expression context.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	19	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization reflects the regulated disassembly of V1 from V0. When V-ATPase disassembles in response to nutrient starvation, the free V1 complex (including C subunit) is released into the cytosol. This is biologically real.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	20	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a different Reactome pathway (ATP6AP1 binds V-ATPase). Same reasoning applies.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	21	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome endosome acidification pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	22	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome transferrin endocytosis pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	23	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome mTORC1 amino acid sensing pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	24	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome mTORC1 pathway (RRAGA,B GDP exchange).
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	25	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome v-ATPase/Ragulator pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	26	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome v-ATPase/Ragulator/SLC38A9 pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	27	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome mTORC1 pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	28	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome mTORC1 pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	29	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome v-ATPase/mTORC1 pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	30	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome mTORC1/RHEB pathway.
human	ATP6V1C1	genes/human/ATP6V1C1/ATP6V1C1-ai-review.yaml	ATP6V1C1	P21283	NCBITaxon:9606	Homo sapiens	31	R-HSA-9858912	MITF-M-dependent ATP6V1C1 gene expression	yes	reactome/R-HSA-9858912.md	MITF-M-dependent ATP6V1C1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome MITF-M-dependent ATP6V1C1 gene expression pathway.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	11	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization reflects the regulated disassembly of V1 from V0; free subunit C is released into the cytosol when the holoenzyme disassembles. This Reactome annotation (intraphagosomal pH lowering) places the V-ATPase machinery in the cytosol.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	12	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a different Reactome reaction (ATP6AP1 binds V-ATPase). Same reasoning applies regarding the free cytosolic V1 pool.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	13	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from the Reactome endosome acidification reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	14	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from the Reactome transferrin-endosome acidification reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	15	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome mTORC1 amino-acid-sensing reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	16	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome mTORC1 reaction (RRAGA,B GDP/GTP exchange).
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	17	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome v-ATPase:Ragulator:SLC38A9 dissociation reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	18	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome v-ATPase:Ragulator:SLC38A9 binding reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	19	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome mTORC1 reaction (RRAGA,B GTP hydrolysis).
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	20	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome mTORC1 reaction (RRAGC,D GTP hydrolysis).
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	21	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome v-ATPase:Ragulator binds mTORC1 reaction.
human	ATP6V1C2	genes/human/ATP6V1C2/ATP6V1C2-ai-review.yaml	ATP6V1C2	Q8NEY4	NCBITaxon:9606	Homo sapiens	22	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from a Reactome mTORC1:RHEB reaction.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	38	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation placing ATP6V1D in specific granule membrane of neutrophils. V-ATPase is present in neutrophil granules.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	39	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for V-ATPase in neutrophil specific granule membrane.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	50	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation placing ATP6V1D in cytosol, consistent with the V1 domain being a peripheral complex on the cytoplasmic face of membranes.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	51	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Additional Reactome TAS annotation for cytosol localization.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	52	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	53	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	54	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in RRAG-related pathway context.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	55	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	56	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	57	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	58	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	59	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	60	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1D	genes/human/ATP6V1D/ATP6V1D-ai-review.yaml	ATP6V1D	Q9Y5K8	NCBITaxon:9606	Homo sapiens	61	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	24	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation. The V1 peripheral sector can dissociate from V0 and exist as a soluble cytoplasmic complex during regulated disassembly.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	25	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	26	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	27	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	28	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	29	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	30	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	31	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	32	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	33	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	34	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	35	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1E1	genes/human/ATP6V1E1/ATP6V1E1-ai-review.yaml	ATP6V1E1	P36543	NCBITaxon:9606	Homo sapiens	36	R-HSA-9858923	MITF-M-dependent ATP6V1E1 gene expression	yes	reactome/R-HSA-9858923.md	MITF-M-dependent ATP6V1E1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in MITF/lysosome biogenesis context.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	13	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol. The V1 sector is cytoplasmic/peripheral, so 'cytosol' is defensible, but it is a coarse location that fails to capture the V-ATPase-complex / organelle-membrane functional context.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	14	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	15	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	16	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	17	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	18	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	19	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	20	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	21	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	22	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	23	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1E2	genes/human/ATP6V1E2/ATP6V1E2-ai-review.yaml	ATP6V1E2	Q96A05	NCBITaxon:9606	Homo sapiens	24	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome reaction-level TAS annotation to cytosol, duplicating other Reactome cytosol annotations for this gene.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	31	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation. V1 F subunit can be in cytosol during regulated V1-V0 disassembly.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	32	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	33	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	34	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	35	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	36	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	37	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	38	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	39	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	40	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	41	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1F	genes/human/ATP6V1F/ATP6V1F-ai-review.yaml	ATP6V1F	Q16864	NCBITaxon:9606	Homo sapiens	42	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	31	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation; cytosolic location reflects regulated disassembly state of free V1 complex.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	32	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; same rationale as above.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	33	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core regulated disassembly state.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	34	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	35	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in mTORC1 signaling context; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	36	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	37	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	38	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	39	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	40	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	41	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	42	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G1	genes/human/ATP6V1G1/ATP6V1G1-ai-review.yaml	ATP6V1G1	O75348	NCBITaxon:9606	Homo sapiens	43	R-HSA-9858924	MITF-M-dependent ATP6V1G1gene expression	yes	reactome/R-HSA-9858924.md	MITF-M-dependent ATP6V1G1gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; non-core.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	17	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome pathway participation (phagosomal acidification); reflects the peripheral/cytosolic-facing V1 sector and reaction-participant context rather than a defining stable location.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	18	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (ATP6AP1 binds V-ATPase); reflects the cytosolic-facing V1 sector in pathway context.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	19	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (endosome acidification); reflects the cytosolic-facing V1 sector in pathway context.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	20	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (acidification of transferrin-containing endosome); reflects pathway participation of the V1 sector.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	21	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation of the V-ATPase.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	22	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	23	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	24	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	25	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	26	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	27	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 amino-acid signaling pathway); reflects pathway participation.
human	ATP6V1G2	genes/human/ATP6V1G2/ATP6V1G2-ai-review.yaml	ATP6V1G2	O95670	NCBITaxon:9606	Homo sapiens	28	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (mTORC1 binds RHEB:GTP); reflects pathway participation.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	10	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation, one of many duplicate cytosol localizations from pathway reactions. Accurate for the peripheral V1 pool but non-core relative to the assembled membrane pump.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	11	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization. Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	12	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization. Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	13	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization. Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	14	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	15	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	16	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	17	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	18	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	19	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	20	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1G3	genes/human/ATP6V1G3/ATP6V1G3-ai-review.yaml	ATP6V1G3	Q96LB4	NCBITaxon:9606	Homo sapiens	21	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol annotation duplicating the V1 peripheral localization (mTORC1 amino-acid signaling context). Real but non-core.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	32	R-HSA-1222516	Intraphagosomal pH is lowered to 5 by V-ATPase	yes	reactome/R-HSA-1222516.md	Intraphagosomal pH is lowered to 5 by V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation; cytosolic localization reflects free V1 complex or V1H in its adaptor role during endocytic events.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	33	R-HSA-167597	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167597.md	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in Nef/CD4 endocytosis context; V1H bridges cytosolic Nef to the AP-2 endocytic complex.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	34	R-HSA-167601	Degradation of CD4	yes	reactome/R-HSA-167601.md	Degradation of CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in CD4 degradation pathway; consistent.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	35	R-HSA-182171	Degradation of CD8	yes	reactome/R-HSA-182171.md	Degradation of CD8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in CD8 degradation pathway; consistent.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	36	R-HSA-182198	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182198.md	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in CD8 internalization; consistent.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	37	R-HSA-5252133	ATP6AP1 binds V-ATPase	yes	reactome/R-HSA-5252133.md	ATP6AP1 binds V-ATPase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; free V1 complex context.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	38	R-HSA-74723	Endosome acidification	yes	reactome/R-HSA-74723.md	Endosome acidification	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; free V1 complex context.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	39	R-HSA-917841	Acidification of Tf:TfR1 containing endosome	yes	reactome/R-HSA-917841.md	Acidification of Tf:TfR1 containing endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; free V1 complex context.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	40	R-HSA-9636397	PtpA binds ATP6V1H	yes	reactome/R-HSA-9636397.md	PtpA binds ATP6V1H	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol; Mycobacterium PtpA binds ATP6V1H context.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	41	R-HSA-9639286	RRAGC,D exchanges GTP for GDP	yes	reactome/R-HSA-9639286.md	RRAGC,D exchanges GTP for GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol in mTORC1 signaling context.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	42	R-HSA-9640167	RRAGA,B exchanges GDP for GTP	yes	reactome/R-HSA-9640167.md	RRAGA,B exchanges GDP for GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	43	R-HSA-9640168	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	yes	reactome/R-HSA-9640168.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	44	R-HSA-9640175	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	yes	reactome/R-HSA-9640175.md	v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	45	R-HSA-9640195	RRAGA,B hydrolyzes GTP	yes	reactome/R-HSA-9640195.md	RRAGA,B hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	46	R-HSA-9645598	RRAGC,D hydrolyzes GTP	yes	reactome/R-HSA-9645598.md	RRAGC,D hydrolyzes GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	47	R-HSA-9645608	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	yes	reactome/R-HSA-9645608.md	v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	48	R-HSA-9646468	mTORC1 binds RHEB:GTP	yes	reactome/R-HSA-9646468.md	mTORC1 binds RHEB:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	49	R-HSA-9858916	MITF-M-dependent ATP6V1H gene expression	yes	reactome/R-HSA-9858916.md	MITF-M-dependent ATP6V1H gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for cytosol.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	50	R-HSA-167537	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167537.md	Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation for plasma membrane in Nef/CD4 complex context; V1H at plasma membrane bridges Nef to AP-2 for CD4 internalization.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	51	R-HSA-167597	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-167597.md	Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for plasma membrane in CD4 internalization context; non-core.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	52	R-HSA-182186	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182186.md	Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for plasma membrane in CD8/Nef complex context; non-core.
human	ATP6V1H	genes/human/ATP6V1H/ATP6V1H-ai-review.yaml	ATP6V1H	Q9UI12	NCBITaxon:9606	Homo sapiens	53	R-HSA-182198	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	yes	reactome/R-HSA-182198.md	Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for plasma membrane in CD8 internalization context; non-core.
human	ATP7B	genes/human/ATP7B/ATP7B-ai-review.yaml	ATP7B	P35670	NCBITaxon:9606	Homo sapiens	6	R-HSA-936895	ATP7B transports cytosolic Cu1+ to Golgi lumen	yes	reactome/R-HSA-936895.md	ATP7B transports cytosolic Cu1+ to Golgi lumen	Homo sapiens	GO:0140581	P-type monovalent copper transporter activity	TAS	enables	MF	false		ACCEPT	Reactome pathway annotation for ATP7B transporting Cu1+ to Golgi lumen. Redundant with IMP evidence.
human	ATP7B	genes/human/ATP7B/ATP7B-ai-review.yaml	ATP7B	P35670	NCBITaxon:9606	Homo sapiens	36	R-HSA-936837	Ion transport by P-type ATPases	yes	reactome/R-HSA-936837.md	Ion transport by P-type ATPases	Homo sapiens	GO:0034220	monoatomic ion transmembrane transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation for ion transport by P-type ATPases. General term.
human	ATP7B	genes/human/ATP7B/ATP7B-ai-review.yaml	ATP7B	P35670	NCBITaxon:9606	Homo sapiens	49	R-HSA-936895	ATP7B transports cytosolic Cu1+ to Golgi lumen	yes	reactome/R-HSA-936895.md	ATP7B transports cytosolic Cu1+ to Golgi lumen	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation. Less specific than TGN membrane.
human	ATRX	genes/human/ATRX/ATRX-ai-review.yaml	ATRX	P46100	NCBITaxon:9606	Homo sapiens	30	R-HSA-9007926	ATRX binds DAXX	yes	reactome/R-HSA-9007926.md	ATRX binds DAXX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	ATRX and DAXX assemble in the nucleoplasm.
human	ATRX	genes/human/ATRX/ATRX-ai-review.yaml	ATRX	P46100	NCBITaxon:9606	Homo sapiens	31	R-HSA-9670101	ATRX:DAXX binds to subtelomeric chromosomal regions	yes	reactome/R-HSA-9670101.md	ATRX:DAXX binds to subtelomeric chromosomal regions	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The subtelomeric ATRX–DAXX event occurs in the nuclear compartment.
human	ATRX	genes/human/ATRX/ATRX-ai-review.yaml	ATRX	P46100	NCBITaxon:9606	Homo sapiens	32	R-HSA-9670114	Histone H3.3 deposition at telomere	yes	reactome/R-HSA-9670114.md	Histone H3.3 deposition at telomere	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The telomeric H3.3-deposition machinery acts in the nucleus.
human	ATRX	genes/human/ATRX/ATRX-ai-review.yaml	ATRX	P46100	NCBITaxon:9606	Homo sapiens	33	R-HSA-9670619	Defective ATRX does not bind DAXX	yes	reactome/R-HSA-9670619.md	Defective ATRX does not bind DAXX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is a core location of normal ATRX, although this Reactome event describes defective ATRX variants.
human	ATRX	genes/human/ATRX/ATRX-ai-review.yaml	ATRX	P46100	NCBITaxon:9606	Homo sapiens	34	R-HSA-9670620	Defective DAXX does not bind ATRX	yes	reactome/R-HSA-9670620.md	Defective DAXX does not bind ATRX	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The normal ATRX compartment remains nucleoplasmic despite the defective-DAXX context of this source event.
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	22	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) assertion that ataxin-3 participates in protein deubiquitination.
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	23	R-HSA-5688797	ATXN3 family cleave Ub chains	yes	reactome/R-HSA-5688797.md	ATXN3 family cleave Ub chains	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of cysteine-type deubiquitinase activity (Ub-chain cleavage).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	24	R-HSA-5688837	ATXN3 deubiquitinates polyUb-PARK2	yes	reactome/R-HSA-5688837.md	ATXN3 deubiquitinates polyUb-PARK2	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of DUB activity in the context of deubiquitinating polyUb-parkin (PARK2).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	30	R-HSA-5688786	ATXN3 binds RAD23	yes	reactome/R-HSA-5688786.md	ATXN3 binds RAD23	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (ATXN3 binds RAD23 reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	31	R-HSA-5688834	ATXN3 binds VCP	yes	reactome/R-HSA-5688834.md	ATXN3 binds VCP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (ATXN3 binds VCP reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	32	R-HSA-9617832	FOXO4:ATXN3 binds SOD2 gene promoter	yes	reactome/R-HSA-9617832.md	FOXO4:ATXN3 binds SOD2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (FOXO4:ATXN3 binds SOD2 promoter reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	33	R-HSA-9617927	FOXO4 binds ATXN3	yes	reactome/R-HSA-9617927.md	FOXO4 binds ATXN3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (FOXO4 binds ATXN3 reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	34	R-HSA-5688797	ATXN3 family cleave Ub chains	yes	reactome/R-HSA-5688797.md	ATXN3 family cleave Ub chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization (Ub-chain cleavage reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	35	R-HSA-5688837	ATXN3 deubiquitinates polyUb-PARK2	yes	reactome/R-HSA-5688837.md	ATXN3 deubiquitinates polyUb-PARK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization (deubiquitinates polyUb-PARK2 reaction context).
human	ATXN3	genes/human/ATXN3/ATXN3-ai-review.yaml	ATXN3	P54252	NCBITaxon:9606	Homo sapiens	36	R-HSA-5689085	ATXN3 binds polyUb-PARK2	yes	reactome/R-HSA-5689085.md	ATXN3 binds polyUb-PARK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization (ATXN3 binds polyUb-PARK2 reaction context).
human	AUH	genes/human/AUH/AUH-ai-review.yaml	AUH	Q13825	NCBITaxon:9606	Homo sapiens	14	R-HSA-9914271	AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA	yes	reactome/R-HSA-9914271.md	AUH mutants don't synthesize 3-hydroxy-methylglutaryl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places AUH in the matrix, independently supported by human-cell mitochondrial subfractionation.
human	AUH	genes/human/AUH/AUH-ai-review.yaml	AUH	Q13825	NCBITaxon:9606	Homo sapiens	20	R-HSA-70785	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA	yes	reactome/R-HSA-70785.md	beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The normal Reactome reaction and independent human-cell subfractionation support matrix localization.
human	AUP1	genes/human/AUP1/AUP1-ai-review.yaml	AUP1	Q9Y679	NCBITaxon:9606	Homo sapiens	15	R-HSA-9921605	NS4A binds AUP1	yes	reactome/R-HSA-9921605.md	NS4A binds AUP1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of ER membrane localization is consistent with the established core localization.
human	AVEN	genes/human/AVEN/AVEN-ai-review.yaml	AVEN	Q9NQS1	NCBITaxon:9606	Homo sapiens	5	R-HSA-6805507	APAF1 binds AVEN	yes	reactome/R-HSA-6805507.md	APAF1 binds AVEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This TAS annotation from Reactome reflects AVEN localization in the cytosol where it can interact with Apaf-1 to inhibit apoptosome assembly. Apoptosome formation occurs in the cytosol following cytochrome c release from mitochondria, so cytosolic localization of AVEN is required for its anti-apoptotic function.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	92	R-HSA-195275	Phosphorylation of APC in the destruction complex	yes	reactome/R-HSA-195275.md	Phosphorylation of APC component of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for phosphorylation of APC in the destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	93	R-HSA-195280	Dissociation of beta-catenin from Axin and association with phospho-APC	yes	reactome/R-HSA-195280.md	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - dissociation of beta-catenin from Axin and association with phospho-APC.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	94	R-HSA-195283	GSK3 phosphorylation of beta-catenin at Ser37	yes	reactome/R-HSA-195283.md	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - GSK3 phosphorylation of beta-catenin at Ser37.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	95	R-HSA-195287	GSK3 phosphorylation of beta-catenin at Thr41	yes	reactome/R-HSA-195287.md	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - GSK3 phosphorylation of beta-catenin at Thr41.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	96	R-HSA-195300	GSK3 phosphorylation of beta-catenin at Ser33	yes	reactome/R-HSA-195300.md	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - GSK3 phosphorylation of beta-catenin at Ser33.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	97	R-HSA-195304	Association of beta-catenin with destruction complex	yes	reactome/R-HSA-195304.md	Association of beta-catenin with the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Association of beta-catenin with destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	98	R-HSA-195318	CK1alpha phosphorylation of beta-catenin at Ser45	yes	reactome/R-HSA-195318.md	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CK1alpha phosphorylation of beta-catenin at Ser45.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	99	R-HSA-2130279	Beta-catenin association with SCF(beta-TrCP) complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Beta-catenin association with SCF(beta-TrCP) complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	100	R-HSA-2130282	Degradation of ubiquitinated beta-catenin	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Degradation of ubiquitinated beta-catenin.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	101	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Multi-ubiquitination of phospho-beta-catenin.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	102	R-HSA-5229343	AXIN phosphorylation in destruction complex	yes	reactome/R-HSA-5229343.md	AXIN is phosphorylated in the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - AXIN phosphorylation in destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	103	R-HSA-5339713	Misspliced GSK3beta mutants stabilize beta-catenin	yes	reactome/R-HSA-5339713.md	Misspliced GSK3beta mutants stabilize beta-catenin levels	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Misspliced GSK3beta mutants stabilize beta-catenin.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	108	R-HSA-4839734	AXIN mutants destabilize destruction complex	yes	reactome/R-HSA-4839734.md	AXIN mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - AXIN mutants destabilize destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	116	R-HSA-4641129	AXIN ubiquitination by SMURF2	yes	reactome/R-HSA-4641129.md	AXIN is ubiquitinated by SMURF2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - AXIN ubiquitination by SMURF2.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	117	R-HSA-4641256	Ubiquitinated AXIN degradation	yes	reactome/R-HSA-4641256.md	Ubiquitinated AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Ubiquitinated AXIN degradation.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	118	R-HSA-3640861	RNF146 ubiquitinates ADP-ribosylated AXIN	yes	reactome/R-HSA-3640861.md	RNF146 ubiquitinates ADP-ribosylated AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - RNF146 ubiquitinates ADP-ribosylated AXIN.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	119	R-HSA-3640872	USP34 deubiquitinates AXIN1/AXIN2	yes	reactome/R-HSA-3640872.md	USP34 deubiquitinates AXIN1,AXIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - USP34 deubiquitinates AXIN1/AXIN2.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	120	R-HSA-3640874	Ub-RibC-AXIN degradation by proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Ub-RibC-AXIN degradation by proteasome.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	121	R-HSA-3640844	RNF146 binds RibC-AXIN:TNKS complex	yes	reactome/R-HSA-3640844.md	RNF146 binds RibC-AXIN:TNKS complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - RNF146 binds RibC-AXIN:TNKS complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	122	R-HSA-3640858	Tankyrase ADP-ribosylates AXIN	yes	reactome/R-HSA-3640858.md	Tankyrase ADP-ribosylates AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Tankyrase ADP-ribosylates AXIN.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	123	R-HSA-1504186	DVL recruits GSK3beta:AXIN1 to receptor complex	yes	reactome/R-HSA-1504186.md	DVL recruits GSK3beta:AXIN1 to the receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - DVL recruits GSK3beta:AXIN1 to receptor complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	124	R-HSA-195251	Assembly of the destruction complex	yes	reactome/R-HSA-195251.md	Assembly of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Assembly of the destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	125	R-HSA-201677	Phosphorylation of LRP5/6 cytoplasmic domain	yes	reactome/R-HSA-201677.md	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Phosphorylation of LRP5/6 cytoplasmic domain.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	126	R-HSA-201685	Beta-catenin release from destruction complex	yes	reactome/R-HSA-201685.md	Beta-catenin is released from the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Beta-catenin release from destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	127	R-HSA-3640862	Tankyrase binds AXIN	yes	reactome/R-HSA-3640862.md	Tankyrase binds AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Tankyrase binds AXIN.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	128	R-HSA-4641134	SMURF2 binds AXIN	yes	reactome/R-HSA-4641134.md	SMURF2 binds AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - SMURF2 binds AXIN.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	129	R-HSA-4791278	APC truncation mutants have impaired AXIN binding	yes	reactome/R-HSA-4791278.md	APC truncation mutants have impaired AXIN binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - APC truncation mutants have impaired AXIN binding.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	130	R-HSA-4827388	CTNNB1 S45 mutants not phosphorylated by CK1alpha	yes	reactome/R-HSA-4827388.md	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CTNNB1 S45 mutants not phosphorylated by CK1alpha.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	131	R-HSA-4839634	CTNNB1 S33 mutants not phosphorylated by GSK3beta	yes	reactome/R-HSA-4839634.md	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CTNNB1 S33 mutants not phosphorylated by GSK3beta.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	132	R-HSA-4839635	CTNNB1 S37 mutants not phosphorylated by GSK3beta	yes	reactome/R-HSA-4839635.md	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CTNNB1 S37 mutants not phosphorylated by GSK3beta.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	133	R-HSA-4839638	CTNNB1 T41 mutants not phosphorylated by GSK3beta	yes	reactome/R-HSA-4839638.md	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CTNNB1 T41 mutants not phosphorylated by GSK3beta.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	134	R-HSA-4839746	Truncated AMER1 mutants destabilize destruction complex	yes	reactome/R-HSA-4839746.md	Truncated AMER1 mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Truncated AMER1 mutants destabilize destruction complex.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	135	R-HSA-5251555	Expression of AXIN1 gene	yes	reactome/R-HSA-5251555.md	Expression of AXIN1 gene	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - Expression of AXIN1 gene.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	136	R-HSA-5368596	WNT3A stimulates caveolin-dependent internalization	yes	reactome/R-HSA-5368596.md	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - WNT3A stimulates caveolin-dependent internalization.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	137	R-HSA-8932076	AXIN1 gene expression regulated by ESR1 and RUNX1	yes	reactome/R-HSA-8932076.md	AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - AXIN1 gene expression regulated by ESR1 and RUNX1.
human	AXIN1	genes/human/AXIN1/AXIN1-ai-review.yaml	AXIN1	O15169	NCBITaxon:9606	Homo sapiens	138	R-NUL-1458902	CK1gamma phosphorylates LRP5/6 (frog model)	yes	reactome/R-NUL-1458902.md	frog CK1gamma phosphorylates LRP5/6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome - CK1gamma phosphorylates LRP5/6 (frog model).
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	60	R-HSA-3640844	RNF146 binds RibC-AXIN:TNKS complex	yes	reactome/R-HSA-3640844.md	RNF146 binds RibC-AXIN:TNKS complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	61	R-HSA-3640858	Tankyrase ADP-ribosylates AXIN	yes	reactome/R-HSA-3640858.md	Tankyrase ADP-ribosylates AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	62	R-HSA-3640861	RNF146 ubiquitinates ADP-ribosylated AXIN	yes	reactome/R-HSA-3640861.md	RNF146 ubiquitinates ADP-ribosylated AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	63	R-HSA-3640862	Tankyrase binds AXIN	yes	reactome/R-HSA-3640862.md	Tankyrase binds AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	64	R-HSA-3640872	USP34 deubiquitinates AXIN1,AXIN2	yes	reactome/R-HSA-3640872.md	USP34 deubiquitinates AXIN1,AXIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	65	R-HSA-3640874	Ub-RibC-AXIN is degraded by the proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	66	R-HSA-4411372	TCF/LEF:CTNNB1 promote transcription of AXIN2	yes	reactome/R-HSA-4411372.md	TCF/LEF:CTNNB1 promote transcription of AXIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated cytosolic localization is consistent with the destruction complex; the event itself regulates AXIN2 expression.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	67	R-HSA-4641129	AXIN is ubiquitinated by SMURF2	yes	reactome/R-HSA-4641129.md	AXIN is ubiquitinated by SMURF2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	68	R-HSA-4641134	SMURF2 binds AXIN	yes	reactome/R-HSA-4641134.md	SMURF2 binds AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	69	R-HSA-4641256	Ubiquitinated AXIN is degraded by the proteasome	yes	reactome/R-HSA-4641256.md	Ubiquitinated AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated pathway context supports cytosolic AXIN2 destruction-complex function.
human	AXIN2	genes/human/AXIN2/AXIN2-ai-review.yaml	AXIN2	Q9Y2T1	NCBITaxon:9606	Homo sapiens	70	R-HSA-9944652	CHD8:CTNNB1 represses AXIN2 expression	yes	reactome/R-HSA-9944652.md	CHD8:CTNNB1 represses AXIN2 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated cytosolic localization is consistent with the destruction complex; the event itself regulates AXIN2 expression.
human	AZIN2	genes/human/AZIN2/AZIN2-ai-review.yaml	AZIN2	Q96A70	NCBITaxon:9606	Homo sapiens	27	R-HSA-351143	Reactome pathway	yes	reactome/R-HSA-351143.md	Agmatine biosynthesis	Homo sapiens	GO:0097055	agmatine biosynthetic process	TAS	involved_in	BP	false		REMOVE	Agmatine biosynthetic process (TAS, Reactome) - the product of arginine decarboxylase, an activity AZIN2 lacks.
human	AZIN2	genes/human/AZIN2/AZIN2-ai-review.yaml	AZIN2	Q96A70	NCBITaxon:9606	Homo sapiens	28	R-HSA-350598	Reactome pathway	yes	reactome/R-HSA-350598.md	Arginine<=>Agmatine+CO2	Homo sapiens	GO:0008792	arginine decarboxylase activity	TAS	enables	MF	false		REMOVE	Legacy positive arginine decarboxylase activity (TAS, Reactome). The CAUTION notes AZIN2 was initially reported to have ODC/ADC activity but the ortholog has neither.
human	AZIN2	genes/human/AZIN2/AZIN2-ai-review.yaml	AZIN2	Q96A70	NCBITaxon:9606	Homo sapiens	50	R-HSA-350598	Reactome pathway	yes	reactome/R-HSA-350598.md	Arginine<=>Agmatine+CO2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for AZIN2.
human	B3GALNT1	genes/human/B3GALNT1/B3GALNT1-ai-review.yaml	B3GALNT1	O75752	NCBITaxon:9606	Homo sapiens	10	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	B3GALNT1 acts in the glycosphingolipid biosynthesis pathway (globo-series branch), adding GalNAc to Gb3Cer. Correct process term; the more precise child globoside biosynthetic process is used in core_functions.
human	B3GALNT1	genes/human/B3GALNT1/B3GALNT1-ai-review.yaml	B3GALNT1	O75752	NCBITaxon:9606	Homo sapiens	11	R-HSA-8878914	B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer	yes	reactome/R-HSA-8878914.md	B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer	Homo sapiens	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer"" directly supports the globoside synthase MF."
human	B3GALNT1	genes/human/B3GALNT1/B3GALNT1-ai-review.yaml	B3GALNT1	O75752	NCBITaxon:9606	Homo sapiens	13	R-HSA-8878914	B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer	yes	reactome/R-HSA-8878914.md	B3GALNT1 transfers GalNAc to Gb3Cer to form Gb4Cer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome describes B3GALNT1 as a Golgi membrane-associated protein performing the Gb3Cer -> Gb4Cer reaction; consistent with UniProt and the IBA/IEA Golgi annotations.
human	B3GALNT2	genes/human/B3GALNT2/B3GALNT2-ai-review.yaml	B3GALNT2	Q8NCR0	NCBITaxon:9606	Homo sapiens	10	R-HSA-8932505	DAG1 core M3 glycosylations	yes	reactome/R-HSA-8932505.md	DAG1 core M3 glycosylations	Homo sapiens	GO:0006493	protein O-linked glycosylation	TAS	involved_in	BP	false		MODIFY	Reactome traceable annotation (DAG1 core M3 glycosylations). Correct directionally; same generality issue as the IBA O-glycosylation term. The Reactome pathway is specifically about alpha-DG core M3 O-mannosyl glycan synthesis, so the more specific O-mannosylation term is preferable.
human	B3GALNT2	genes/human/B3GALNT2/B3GALNT2-ai-review.yaml	B3GALNT2	Q8NCR0	NCBITaxon:9606	Homo sapiens	11	R-HSA-8931648	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1	yes	reactome/R-HSA-8931648.md	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1	Homo sapiens	GO:0008376	acetylgalactosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	"Correct and specific molecular function from the Reactome reaction ""B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1"". This is the core catalytic activity of the enzyme. Accept (concordant with the IDA annotation)."
human	B3GALNT2	genes/human/B3GALNT2/B3GALNT2-ai-review.yaml	B3GALNT2	Q8NCR0	NCBITaxon:9606	Homo sapiens	12	R-HSA-8931648	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1	yes	reactome/R-HSA-8931648.md	B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the reaction at the ER membrane, consistent with the experimental ER localization (PMID:23453667) and the fact that the enzyme is a single-pass ER/Golgi membrane protein acting on the O-mannosyl glycan that is assembled in the ER. Accept; this is the precise membrane sub-location.
human	B3GALT6	genes/human/B3GALT6/B3GALT6-ai-review.yaml	B3GALT6	Q96L58	NCBITaxon:9606	Homo sapiens	2	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	The normal linker-synthesis reaction occurs at the Golgi membrane.
human	B3GALT6	genes/human/B3GALT6/B3GALT6-ai-review.yaml	B3GALT6	Q96L58	NCBITaxon:9606	Homo sapiens	3	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	The disease reaction preserves the normal enzyme's Golgi location.
human	B3GALT6	genes/human/B3GALT6/B3GALT6-ai-review.yaml	B3GALT6	Q96L58	NCBITaxon:9606	Homo sapiens	25	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0047220	galactosylxylosylprotein 3-beta-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	The normal Reactome reaction matches GalT-II catalysis.
human	B3GALT6	genes/human/B3GALT6/B3GALT6-ai-review.yaml	B3GALT6	Q96L58	NCBITaxon:9606	Homo sapiens	26	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0047220	galactosylxylosylprotein 3-beta-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	The disease event identifies disruption of the normal GalT-II reaction.
human	B3GALT6	genes/human/B3GALT6/B3GALT6-ai-review.yaml	B3GALT6	Q96L58	NCBITaxon:9606	Homo sapiens	29	R-HSA-1971475	Glycosaminoglycan-protein linkage region biosynthesis	yes	reactome/R-HSA-1971475.md	Glycosaminoglycan-protein linkage region biosynthesis	Homo sapiens	GO:0120532	glycosaminoglycan-protein linkage region biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Linker-region biosynthesis is the precise core process.
human	B3GLCT	genes/human/B3GLCT/B3GLCT-ai-review.yaml	B3GLCT	Q6Y288	NCBITaxon:9606	Homo sapiens	3	R-HSA-5173005	B3GALTL transfers glucose to O-fucosyl-proteins	yes	reactome/R-HSA-5173005.md	B3GALTL transfers glucose to O-fucosyl-proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The normal Reactome glucosylation reaction places B3GLCT at the ER membrane.
human	B3GLCT	genes/human/B3GLCT/B3GLCT-ai-review.yaml	B3GLCT	Q6Y288	NCBITaxon:9606	Homo sapiens	4	R-HSA-6785565	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	yes	reactome/R-HSA-6785565.md	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The disease-pathway source retains the normal enzyme's ER compartment.
human	B3GLCT	genes/human/B3GLCT/B3GLCT-ai-review.yaml	B3GLCT	Q6Y288	NCBITaxon:9606	Homo sapiens	8	R-HSA-5173005	B3GALTL transfers glucose to O-fucosyl-proteins	yes	reactome/R-HSA-5173005.md	B3GALTL transfers glucose to O-fucosyl-proteins	Homo sapiens	GO:0016757	glycosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine the general activity to the specific reaction described by Reactome.
human	B3GLCT	genes/human/B3GLCT/B3GLCT-ai-review.yaml	B3GLCT	Q6Y288	NCBITaxon:9606	Homo sapiens	9	R-HSA-6785565	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	yes	reactome/R-HSA-6785565.md	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	Homo sapiens	GO:0016757	glycosyltransferase activity	TAS	enables	MF	false		MODIFY	Refine the general wild-type activity while preserving the disease-event provenance.
human	B3GLCT	genes/human/B3GLCT/B3GLCT-ai-review.yaml	B3GLCT	Q6Y288	NCBITaxon:9606	Homo sapiens	12	R-HSA-5173214	O-glycosylation of TSR domain-containing proteins	yes	reactome/R-HSA-5173214.md	O-glycosylation of TSR domain-containing proteins	Homo sapiens	GO:0036066	protein O-linked glycosylation via fucose	TAS	involved_in	BP	false		ACCEPT	The Reactome TSR glycosylation pathway correctly assigns B3GLCT the elongation step.
human	B3GNT5	genes/human/B3GNT5/B3GNT5-ai-review.yaml	B3GNT5	Q9BYG0	NCBITaxon:9606	Homo sapiens	11	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Accurate core biological process. B3GNT5 initiates the (neo)lacto-series branch of glycosphingolipid biosynthesis by making Lc3Cer. Supported by Reactome and consistent with UniProt. Accepted as the core process (no more specific lacto-series term exists in GO).
human	B3GNT5	genes/human/B3GNT5/B3GNT5-ai-review.yaml	B3GNT5	Q9BYG0	NCBITaxon:9606	Homo sapiens	12	R-HSA-9846501	B3GNT5 transfers GlcNAc to LacCer	yes	reactome/R-HSA-9846501.md	B3GNT5 transfers GlcNAc to LacCer	Homo sapiens	GO:0047256	lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	"Precise core molecular function, curated by Reactome from the reaction ""B3GNT5 transfers GlcNAc to LacCer"". Matches the experimental EC 2.4.1.206 activity. Accepted."
human	B3GNT5	genes/human/B3GNT5/B3GNT5-ai-review.yaml	B3GNT5	Q9BYG0	NCBITaxon:9606	Homo sapiens	15	R-HSA-9846501	B3GNT5 transfers GlcNAc to LacCer	yes	reactome/R-HSA-9846501.md	B3GNT5 transfers GlcNAc to LacCer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi-membrane localization curated by Reactome, consistent with the UniProt location and the IBA/IEA Golgi annotations. Accepted as core localization.
human	B4GALNT1	genes/human/B4GALNT1/B4GALNT1-ai-review.yaml	B4GALNT1	Q00973	NCBITaxon:9606	Homo sapiens	17	R-HSA-8856223	B4GALNT1 dimer transfers GalNAc to gangliosides	yes	reactome/R-HSA-8856223.md	B4GALNT1 dimer transfers GalNAc to gangliosides	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	The Reactome reaction places the catalytic enzyme at the Golgi membrane.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	18	R-HSA-5653890	Lactose synthesis	yes	reactome/R-HSA-5653890.md	Lactose synthesis	Homo sapiens	GO:0005989	lactose biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation for lactose synthesis. B4GALT1, in the lactose synthase complex, is the catalytic component producing lactose in lactating mammary gland (PMID:11419947; PMID:806951). This is a genuine, tissue-specific core process. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	19	R-HSA-3656230	Defective B4GALT1 does not transfer Gal to the keratan chain	yes	reactome/R-HSA-3656230.md	Defective B4GALT1 does not transfer Gal to the keratan chain	Homo sapiens	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction (""Defective B4GALT1 does not transfer Gal to the keratan chain"") annotating the core galactosyltransferase activity (here in the keratan sulfate context). Correct core MF. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	20	R-HSA-4793956	Defective B4GALT1 does not add Gal to N-glycan	yes	reactome/R-HSA-4793956.md	Defective B4GALT1 does not add Gal to N-glycan	Homo sapiens	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction (""Defective B4GALT1 does not add Gal to N-glycan"") annotating the core N-glycan galactosyltransferase activity. Correct core MF. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	21	R-HSA-9035949	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-9035949.md	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	Homo sapiens	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction annotating the core galactosyltransferase activity (N-glycan precursor context). Redundant with the other MF annotations; correct. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	22	R-HSA-9035950	Defective B4GALT1 does not transfer Gal to a branch of keratan	yes	reactome/R-HSA-9035950.md	Defective B4GALT1 does not transfer Gal to a branch of keratan	Homo sapiens	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction annotating the core galactosyltransferase activity (keratan branch context). Correct core MF. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	40	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation pathway annotation. Reflects presence of B4GALT1 in granule-membrane proteomes during exocytosis rather than a core functional location. Keep as non-core.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	41	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil azurophil-granule annotation, from large-scale granule proteomics. Not a core functional compartment for the galactosyltransferase. Keep as non-core.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	50	R-HSA-3656230	Defective B4GALT1 does not transfer Gal to the keratan chain	yes	reactome/R-HSA-3656230.md	Defective B4GALT1 does not transfer Gal to the keratan chain	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the (defective) keratan-galactosylation reaction at the Golgi membrane. Correct core location. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	51	R-HSA-4793956	Defective B4GALT1 does not add Gal to N-glycan	yes	reactome/R-HSA-4793956.md	Defective B4GALT1 does not add Gal to N-glycan	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi membrane location for the N-glycan galactosylation reaction. Correct core location. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	52	R-HSA-9035949	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-9035949.md	Defective B4GALT1 does not transfer Gal to the N-glycan precursor	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi membrane location (N-glycan precursor reaction). Correct core location, redundant with the other Golgi membrane annotations. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	53	R-HSA-9035950	Defective B4GALT1 does not transfer Gal to a branch of keratan	yes	reactome/R-HSA-9035950.md	Defective B4GALT1 does not transfer Gal to a branch of keratan	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi membrane location (keratan branch reaction). Correct core location. Accept.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	54	R-HSA-1297338	Association of ADAM and B4GALT1 With ZP3	yes	reactome/R-HSA-1297338.md	Association of ADAM and B4GALT1 With ZP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome annotation for ""Association of ADAM and B4GALT1 With ZP3"" (fertilization / sperm-egg binding), placing the surface form at the plasma membrane. Reflects the specialized cell-surface recognition role of the long isoform. Keep as non-core."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	55	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation pathway (plasma-membrane fusion of azurophil granules). Non-core trafficking location. Keep as non-core.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	56	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome secretory-granule exocytosis pathway. Non-core trafficking location. Keep as non-core.
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	57	R-HSA-2025723	B4GALTs transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-2025723.md	B4GALTs transfer Gal to the N-glycan precursor	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location (""B4GALTs transfer Gal to the N-glycan precursor""). Correct core location. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	58	R-HSA-2046265	B4GALTs transfer Gal to the keratan chain	yes	reactome/R-HSA-2046265.md	B4GALTs transfer Gal to the keratan chain	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location (""B4GALTs transfer Gal to the keratan chain""). Correct core location. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	59	R-HSA-2046298	B4GALTs transfer Gal to a branch of keratan	yes	reactome/R-HSA-2046298.md	B4GALTs transfer Gal to a branch of keratan	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location (""B4GALTs transfer Gal to a branch of keratan""). Correct core location. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	60	R-HSA-5653878	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac	yes	reactome/R-HSA-5653878.md	B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location for ""B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac"" (lactose synthesis occurs in the Golgi). Correct core location. Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	61	R-HSA-5653886	B4GALT1 binds LALBA	yes	reactome/R-HSA-5653886.md	B4GALT1 binds LALBA	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location for ""B4GALT1 binds LALBA"". Correct core location (lactose synthase assembly in the Golgi). Accept."
human	B4GALT1	genes/human/B4GALT1/B4GALT1-ai-review.yaml	B4GALT1	P15291	NCBITaxon:9606	Homo sapiens	62	R-HSA-975919	Addition of galactose by beta 4-galactosyltransferases	yes	reactome/R-HSA-975919.md	Addition of galactose by beta 4-galactosyltransferases	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome Golgi membrane location (""Addition of galactose by beta 4-galactosyltransferases""). Correct core location. Accept."
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	20	R-HSA-913709	O-linked glycosylation of mucins	yes	reactome/R-HSA-913709.md	O-linked glycosylation of mucins	Homo sapiens	GO:0016266	protein O-linked glycosylation via N-acetylgalactosamine	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome pathway annotation (""O-linked glycosylation of mucins""). B4GALT5 can add galactose within elongating O-glycan cores, hence its inclusion in this pathway, but O-GalNAc mucin glycosylation is a peripheral, pathway-membership activity rather than a core function of this enzyme. Keep as non-core."
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	23	R-HSA-1964501	Addition of galactose to Core 6 glycoprotein	yes	reactome/R-HSA-1964501.md	Addition of galactose to Core 6 glycoprotein	Homo sapiens	GO:0008378	galactosyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS to the general galactosyltransferase activity (via the ""Addition of galactose to Core 6 glycoprotein"" reaction). Correct at the family level but subsumed by the specific LacCer-synthase (GO:0008489) and beta-1,4-galactosyltransferase (GO:0003831) terms."
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	32	R-HSA-1964501	Addition of galactose to Core 6 glycoprotein	yes	reactome/R-HSA-1964501.md	Addition of galactose to Core 6 glycoprotein	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to Golgi membrane. Accurate and consistent with UniProt; redundant with the ARBA IEA Golgi-membrane annotation.
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	33	R-HSA-2025723	B4GALTs transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-2025723.md	B4GALTs transfer Gal to the N-glycan precursor	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS Golgi-membrane localization from a distinct N-glycan reaction; redundant duplicate of the same correct location. Localization accepted.
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	34	R-HSA-2046265	B4GALTs transfer Gal to the keratan chain	yes	reactome/R-HSA-2046265.md	B4GALTs transfer Gal to the keratan chain	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS Golgi-membrane localization (keratan sulfate reaction); redundant duplicate of the same correct location. Localization accepted.
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	35	R-HSA-2046298	B4GALTs transfer Gal to a branch of keratan	yes	reactome/R-HSA-2046298.md	B4GALTs transfer Gal to a branch of keratan	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS Golgi-membrane localization (keratan branch reaction); redundant duplicate of the same correct location. Localization accepted.
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	36	R-HSA-975919	Addition of galactose by beta 4-galactosyltransferases	yes	reactome/R-HSA-975919.md	Addition of galactose by beta 4-galactosyltransferases	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS Golgi-membrane localization (Gal addition by beta-4-GalTs); redundant duplicate of the same correct location. Localization accepted.
human	B4GALT5	genes/human/B4GALT5/B4GALT5-ai-review.yaml	B4GALT5	O43286	NCBITaxon:9606	Homo sapiens	37	R-HSA-9851347	B4GALT5/6 transfer Gal to GlcCer	yes	reactome/R-HSA-9851347.md	B4GALT5/6 transfer Gal to GlcCer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS Golgi-membrane localization from the reaction ""B4GALT5/6 transfer Gal to GlcCer"" (LacCer synthesis) - the most directly relevant Reactome reaction for this enzyme. Localization is correct and consistent with UniProt; accepted."
human	B4GALT6	genes/human/B4GALT6/B4GALT6-ai-review.yaml	B4GALT6	Q9UBX8	NCBITaxon:9606	Homo sapiens	26	R-HSA-2025723	B4GALTs transfer Gal to the N-glycan precursor	yes	reactome/R-HSA-2025723.md	B4GALTs transfer Gal to the N-glycan precursor	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted Golgi membrane location, from a generic B4GALT reaction (transfer of Gal to the N-glycan precursor). The Golgi membrane location is correct for B4GALT6 (single-pass type II Golgi stack membrane protein) even though the specific N-glycan reaction is a family-level context rather than the established glycolipid role. The Golgi membrane location is accepted.
human	B4GALT6	genes/human/B4GALT6/B4GALT6-ai-review.yaml	B4GALT6	Q9UBX8	NCBITaxon:9606	Homo sapiens	27	R-HSA-2046265	B4GALTs transfer Gal to the keratan chain	yes	reactome/R-HSA-2046265.md	B4GALTs transfer Gal to the keratan chain	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted Golgi membrane location from a generic B4GALT keratan-chain reaction. Location correct for B4GALT6; the specific keratan reaction is a family-level assignment. Golgi membrane location accepted.
human	B4GALT6	genes/human/B4GALT6/B4GALT6-ai-review.yaml	B4GALT6	Q9UBX8	NCBITaxon:9606	Homo sapiens	28	R-HSA-2046298	B4GALTs transfer Gal to a branch of keratan	yes	reactome/R-HSA-2046298.md	B4GALTs transfer Gal to a branch of keratan	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted Golgi membrane location from a generic B4GALT keratan-branch reaction. Location correct; specific reaction is family-level. Golgi membrane location accepted.
human	B4GALT6	genes/human/B4GALT6/B4GALT6-ai-review.yaml	B4GALT6	Q9UBX8	NCBITaxon:9606	Homo sapiens	29	R-HSA-975919	Addition of galactose by beta 4-galactosyltransferases	yes	reactome/R-HSA-975919.md	Addition of galactose by beta 4-galactosyltransferases	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted Golgi membrane location from a generic beta-4-galactosyl transfer reaction. Location correct for B4GALT6. Golgi membrane location accepted.
human	B4GALT6	genes/human/B4GALT6/B4GALT6-ai-review.yaml	B4GALT6	Q9UBX8	NCBITaxon:9606	Homo sapiens	30	R-HSA-9851347	B4GALT5/6 transfer Gal to GlcCer	yes	reactome/R-HSA-9851347.md	B4GALT5/6 transfer Gal to GlcCer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted Golgi membrane location from the reaction B4GALT5/6 transfer Gal to GlcCer, i.e. lactosylceramide synthesis, the established B4GALT6 function. This is the most relevant Reactome context: correct Golgi membrane location for the LacCer-synthase activity. Accept the location.
human	B4GALT7	genes/human/B4GALT7/B4GALT7-ai-review.yaml	B4GALT7	Q9UBV7	NCBITaxon:9606	Homo sapiens	2	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the site of the membrane-anchored linker enzyme.
human	B4GALT7	genes/human/B4GALT7/B4GALT7-ai-review.yaml	B4GALT7	Q9UBV7	NCBITaxon:9606	Homo sapiens	3	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the site of the membrane-anchored linker enzyme.
human	B4GALT7	genes/human/B4GALT7/B4GALT7-ai-review.yaml	B4GALT7	Q9UBV7	NCBITaxon:9606	Homo sapiens	35	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	B4GALT7 catalyzes the xylose-directed first galactose addition.
human	B4GALT7	genes/human/B4GALT7/B4GALT7-ai-review.yaml	B4GALT7	Q9UBV7	NCBITaxon:9606	Homo sapiens	36	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0046525	xylosylprotein 4-beta-galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	B4GALT7 catalyzes the xylose-directed first galactose addition.
human	B4GALT7	genes/human/B4GALT7/B4GALT7-ai-review.yaml	B4GALT7	Q9UBV7	NCBITaxon:9606	Homo sapiens	39	R-HSA-1971475	Glycosaminoglycan-protein linkage region biosynthesis	yes	reactome/R-HSA-1971475.md	Glycosaminoglycan-protein linkage region biosynthesis	Homo sapiens	GO:0120532	glycosaminoglycan-protein linkage region biosynthetic process	TAS	involved_in	BP	false		ACCEPT	The enzyme catalyzes the second sugar-addition step of the common proteoglycan linker.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	27	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation placing BAAT in bile acid biosynthesis. BAAT catalyzes the terminal conjugation step of bile-acid synthesis, so this is a core biosynthetic-process annotation.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	28	R-HSA-159431	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	yes	reactome/R-HSA-159431.md	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	Homo sapiens	GO:0008206	bile acid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation to bile acid metabolic process (duplicate of the IBA). Correct broad process term for the bile-acid-conjugating enzyme.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	35	R-HSA-159431	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	yes	reactome/R-HSA-159431.md	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	Homo sapiens	GO:0016746	acyltransferase activity	TAS	enables	MF	false		MODIFY	Reactome (TAS) general acyltransferase activity. Correct but a general parent of the specific bile acid-CoA:amino acid N-acyltransferase function.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	36	R-HSA-192312	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate	yes	reactome/R-HSA-192312.md	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate	Homo sapiens	GO:0016746	acyltransferase activity	TAS	enables	MF	false		MODIFY	Reactome (TAS) general acyltransferase activity (choloyl-CoA + glycine/taurine reaction). Correct but general.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	37	R-HSA-193491	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate	yes	reactome/R-HSA-193491.md	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate	Homo sapiens	GO:0016746	acyltransferase activity	TAS	enables	MF	false		MODIFY	Reactome (TAS) general acyltransferase activity (chenodeoxycholoyl-CoA + glycine/taurine reaction). Correct but general.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	40	R-HSA-192312	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate	yes	reactome/R-HSA-192312.md	Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) peroxisomal matrix localization. BAAT is a soluble matrix enzyme imported into peroxisomes (PTS-dependent), consistent with matrix (a child of peroxisome) location.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	41	R-HSA-193491	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate	yes	reactome/R-HSA-193491.md	Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) peroxisomal matrix localization (chenodeoxycholoyl-CoA conjugation reaction). Consistent with BAAT being a matrix peroxisomal enzyme.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	42	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) peroxisomal matrix localization (peroxisomal protein import). BAAT is a PTS-containing cargo imported into the peroxisomal matrix.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	43	R-HSA-159431	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	yes	reactome/R-HSA-159431.md	Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization (bile acid conjugation reaction placed in the cytosol). Consistent with the cytosolic BAAT pool.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	44	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization (peroxisomal import - cargo starts in the cytosol before translocation). Consistent with cytosolic BAAT prior to peroxisomal import.
human	BAAT	genes/human/BAAT/BAAT-ai-review.yaml	BAAT	Q14032	NCBITaxon:9606	Homo sapiens	45	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization (PEX5 docking of cargo). Consistent with cytosolic BAAT prior to peroxisomal import.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	59	R-HSA-5692495	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	yes	reactome/R-HSA-5692495.md	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	Homo sapiens	GO:0008798	beta-aspartyl-peptidase activity	TAS	enables	MF	false		ACCEPT	beta-aspartyl-peptidase activity is retained as a core molecular-function annotation for BACE1; it captures activity or binding specificity within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	74	R-HSA-977225	Amyloid fiber formation	yes	reactome/R-HSA-977225.md	Amyloid fiber formation	Homo sapiens	GO:1990000	amyloid fibril formation	TAS	involved_in	BP	false		MODIFY	amyloid fibril formation is directionally related to BACE1 biology but is not the best curation target; amyloid-beta formation, amyloid precursor protein catabolic process better captures the specific supported function or process.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	108	R-HSA-5692934	BACE1 binds GGA1,2,3	yes	reactome/R-HSA-5692934.md	BACE1 binds GGA1,2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	109	R-HSA-5692941	BACE1:GGA1,2,3 translocates from plasma membrane to endosome	yes	reactome/R-HSA-5692941.md	BACE1:GGA1,2,3 translocates from plasma membrane to endosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	110	R-HSA-5693086	BACE1(46-501) translocates from Golgi lumen to plasma membrane	yes	reactome/R-HSA-5693086.md	BACE1(46-501) translocates from Golgi lumen to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	111	R-HSA-5693001	NAT8,8B acetylate BACE1	yes	reactome/R-HSA-5693001.md	NAT8,8B acetylate BACE1	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is retained as a non-core cellular-component/localization annotation for BACE1; it records a supported context, interaction, localization, or pathway branch that is secondary to BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	112	R-HSA-5693071	BACE1 translocates from ER lumen to Golgi apparatus	yes	reactome/R-HSA-5693071.md	BACE1 translocates from ER lumen to Golgi apparatus	Homo sapiens	GO:0070931	Golgi-associated vesicle lumen	TAS	located_in	CC	false		ACCEPT	Golgi-associated vesicle lumen is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	113	R-HSA-5693081	FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)	yes	reactome/R-HSA-5693081.md	FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)	Homo sapiens	GO:0070931	Golgi-associated vesicle lumen	TAS	located_in	CC	false		ACCEPT	Golgi-associated vesicle lumen is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	114	R-HSA-5693071	BACE1 translocates from ER lumen to Golgi apparatus	yes	reactome/R-HSA-5693071.md	BACE1 translocates from ER lumen to Golgi apparatus	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is retained as a non-core cellular-component/localization annotation for BACE1; it records a supported context, interaction, localization, or pathway branch that is secondary to BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	115	R-HSA-5692495	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	yes	reactome/R-HSA-5692495.md	BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	116	R-HSA-5692941	BACE1:GGA1,2,3 translocates from plasma membrane to endosome	yes	reactome/R-HSA-5692941.md	BACE1:GGA1,2,3 translocates from plasma membrane to endosome	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	117	R-HSA-5693086	BACE1(46-501) translocates from Golgi lumen to plasma membrane	yes	reactome/R-HSA-5693086.md	BACE1(46-501) translocates from Golgi lumen to plasma membrane	Homo sapiens	GO:0070931	Golgi-associated vesicle lumen	TAS	located_in	CC	false		ACCEPT	Golgi-associated vesicle lumen is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BACE1	genes/human/BACE1/BACE1-ai-review.yaml	BACE1	P56817	NCBITaxon:9606	Homo sapiens	118	R-HSA-5693092	Unknown deacetylase deacetylates 7K-BACE1(46-501)	yes	reactome/R-HSA-5693092.md	Unknown deacetylase deacetylates 7K-BACE1(46-501)	Homo sapiens	GO:0070931	Golgi-associated vesicle lumen	TAS	located_in	CC	false		ACCEPT	Golgi-associated vesicle lumen is retained as a core cellular-component/localization annotation for BACE1; it captures site of action or component context within the synthesized core biology: BACE1 beta-secretase/aspartyl endopeptidase activity, amyloidogenic APP processing, membrane-substrate proteolysis, and TGN/endosomal trafficking that controls substrate access and enzyme turnover.
human	BAG1	genes/human/BAG1/BAG1-ai-review.yaml	BAG1	Q99933	NCBITaxon:9606	Homo sapiens	31	R-HSA-5252079	HSP110s exchange ATP for ADP on HSP70s:ADP	yes	reactome/R-HSA-5252079.md	HSP110s exchange ATP for ADP on HSP70s:ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for HSP110-mediated nucleotide exchange on HSP70. BAG1 is part of the cytosolic chaperone machinery.
human	BAG2	genes/human/BAG2/BAG2-ai-review.yaml	BAG2	O95816	NCBITaxon:9606	Homo sapiens	60	R-HSA-5252079	HSP110s exchange ATP for ADP on HSP70s:ADP	yes	reactome/R-HSA-5252079.md	HSP110s exchange ATP for ADP on HSP70s:ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	BAG2 is a cytosolic co-chaperone; cytosolic localization is the core compartment for its HSP70 NEF/CHIP-regulatory activity.
human	BAG3	genes/human/BAG3/BAG3-ai-review.yaml	BAG3	O95817	NCBITaxon:9606	Homo sapiens	72	R-HSA-5252079	HSP110s exchange ATP for ADP on HSP70s:ADP	yes	reactome/R-HSA-5252079.md	HSP110s exchange ATP for ADP on HSP70s:ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places BAG-family NEF activity in the cytosolic HSP70 nucleotide-exchange pathway.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	80	R-HSA-2029465	RAC1:GTP and PIP3 bind WAVE Regulatory Complex	yes	reactome/R-HSA-2029465.md	RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: RAC1:GTP and PIP3 bind WAVE Regulatory Complex.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	81	R-HSA-2029466	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	yes	reactome/R-HSA-2029466.md	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	82	R-HSA-2029469	p-ERK phosphorylates WAVEs and ABI	yes	reactome/R-HSA-2029469.md	p-ERK phosphorylates WAVEs and ABI	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: p-ERK phosphorylates WAVEs and ABI.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	83	R-HSA-2130194	ABL phosphorylates WAVEs	yes	reactome/R-HSA-2130194.md	ABL phosphorylates WAVEs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: ABL phosphorylates WAVEs.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	84	R-HSA-2197690	Detachment of WASP/WAVE	yes	reactome/R-HSA-2197690.md	Detachment of WASP/WAVE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Detachment of WASP/WAVE.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	85	R-HSA-9013145	RAC1 binds effectors at the plasma membrane	yes	reactome/R-HSA-9013145.md	RAC1 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: RAC1 binds effectors at the plasma membrane.
human	BAIAP2	genes/human/BAIAP2/BAIAP2-ai-review.yaml	BAIAP2	Q9UQB8	NCBITaxon:9606	Homo sapiens	86	R-HSA-9013157	CDC42 binds effectors at the plasma membrane	yes	reactome/R-HSA-9013157.md	CDC42 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: CDC42 binds effectors at the plasma membrane.
human	BAIAP2L1	genes/human/BAIAP2L1/BAIAP2L1-ai-review.yaml	BAIAP2L1	Q9UHR4	NCBITaxon:9606	Homo sapiens	22	R-HSA-9693125	RHOF binds effectors at the plasma membrane	yes	reactome/R-HSA-9693125.md	RHOF binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RHOF GTPase cycle indicates cytosolic localization.
human	BAIAP2L2	genes/human/BAIAP2L2/BAIAP2L2-ai-review.yaml	BAIAP2L2	Q6UXY1	NCBITaxon:9606	Homo sapiens	14	R-HSA-9693125	RHOF binds effectors at the plasma membrane	yes	reactome/R-HSA-9693125.md	RHOF binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""RHOF binds effectors at the plasma membrane"". Duplicate of IBA annotation above. Cytosolic pool exists as part of dynamic membrane recruitment."
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	17	R-HSA-5690759	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1	yes	reactome/R-HSA-5690759.md	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome assigns BAP1 the catalytic role in HCF-1 deubiquitination.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	18	R-HSA-5690790	Histone H2A is dubiquitinated by the PR-DUB complex	yes	reactome/R-HSA-5690790.md	Histone H2A is dubiquitinated by the PR-DUB complex	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	BAP1 supplies the deubiquitinase chemistry in the Reactome PR-DUB reaction.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	49	R-HSA-5689630	BAP1 binds BAP1-interacting complex	yes	reactome/R-HSA-5689630.md	BAP1 binds BAP1-interacting complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	50	R-HSA-5689649	BAP1 binds BRCA1:BARD1	yes	reactome/R-HSA-5689649.md	BAP1 binds BRCA1:BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	51	R-HSA-5690759	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1	yes	reactome/R-HSA-5690759.md	BAP1:Ub-HCFC1 deubiquitinates BAP1:Ub-HCFC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	52	R-HSA-5690785	BAP1 binds Ub-HCFC1	yes	reactome/R-HSA-5690785.md	BAP1 binds Ub-HCFC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	53	R-HSA-5690790	Histone H2A is dubiquitinated by the PR-DUB complex	yes	reactome/R-HSA-5690790.md	Histone H2A is dubiquitinated by the PR-DUB complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	54	R-HSA-9700998	BAP1 disrupts the BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9700998.md	BAP1 disrupts the BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	55	R-HSA-9701003	BAP1 binds BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9701003.md	BAP1 binds BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization is consistent with the curated reaction context.
human	BAP1	genes/human/BAP1/BAP1-ai-review.yaml	BAP1	Q92560	NCBITaxon:9606	Homo sapiens	73	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	BAP1 is a catalytic participant in protein deubiquitination.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	60	R-HSA-5659781	BRCA1 forms a heterodimer with BARD1	yes	reactome/R-HSA-5659781.md	BRCA1 forms a heterodimer with BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	61	R-HSA-5683385	Formation of BRCA1-A complex at DNA DSBs	yes	reactome/R-HSA-5683385.md	Formation of BRCA1-A complex at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	62	R-HSA-5683735	CHEK2 is recruited to DNA DSBs	yes	reactome/R-HSA-5683735.md	CHEK2 is recruited to DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	63	R-HSA-5683801	CHEK2 phosphorylates BRCA1	yes	reactome/R-HSA-5683801.md	CHEK2 phosphorylates BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	64	R-HSA-5684052	PIAS4 SUMOylates MDC1	yes	reactome/R-HSA-5684052.md	PIAS4 SUMOylates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	65	R-HSA-5684071	RNF4 ubiquitinates MDC1	yes	reactome/R-HSA-5684071.md	RNF4 ubiquitinates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	66	R-HSA-5684108	BRCA1 binds phosphorylated RBBP8	yes	reactome/R-HSA-5684108.md	BRCA1 binds phosphorylated RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	67	R-HSA-5684875	Binding of ATR:ATRIP to RPA at resected DNA DSBs	yes	reactome/R-HSA-5684875.md	Binding of ATR:ATRIP to RPA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	68	R-HSA-5684882	CHEK1 is recruited to resected DNA DSBs	yes	reactome/R-HSA-5684882.md	CHEK1 is recruited to resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	69	R-HSA-5684887	Activation of CHEK1 at resected DNA DSBs	yes	reactome/R-HSA-5684887.md	Activation of CHEK1 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	70	R-HSA-5685011	ATR activation at DNA DSBs	yes	reactome/R-HSA-5685011.md	ATR activation at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	71	R-HSA-5685156	ATR phosphorylates RPA2	yes	reactome/R-HSA-5685156.md	ATR phosphorylates RPA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	72	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	73	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	74	R-HSA-5685985	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	yes	reactome/R-HSA-5685985.md	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	75	R-HSA-5685994	Long-range resection of DNA DSBs by EXO1 or DNA2	yes	reactome/R-HSA-5685994.md	Long-range resection of DNA DSBs by EXO1 or DNA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	76	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	77	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	78	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	79	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	80	R-HSA-5686642	RAD52 promotes single strand annealing at resected DNA DSBs	yes	reactome/R-HSA-5686642.md	RAD52 promotes single strand annealing at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	81	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	82	R-HSA-5686663	Completion of SSA	yes	reactome/R-HSA-5686663.md	Completion of SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	83	R-HSA-5686685	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5686685.md	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	84	R-HSA-5689649	BAP1 binds BRCA1:BARD1	yes	reactome/R-HSA-5689649.md	BAP1 binds BRCA1:BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	85	R-HSA-5691411	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	yes	reactome/R-HSA-5691411.md	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	86	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	87	R-HSA-5693542	Association of RPA complexes with ssDNA at resected DNA DSBs	yes	reactome/R-HSA-5693542.md	Association of RPA complexes with ssDNA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	88	R-HSA-5693551	Phosphorylation of BRCA1-A complex at multiple sites by ATM	yes	reactome/R-HSA-5693551.md	Phosphorylation of BRCA1-A complex at multiple sites by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	89	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	90	R-HSA-5693564	Association of RAD51 with RAD52:DNA double-strand break ends	yes	reactome/R-HSA-5693564.md	Association of RAD51 with RAD52:DNA double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	91	R-HSA-5693580	Association of RAD52 with the RPA complex at resected DNA DSBs	yes	reactome/R-HSA-5693580.md	Association of RAD52 with the RPA complex at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	92	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	93	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	94	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	95	R-HSA-5693608	Initial resection of double-strand break ends	yes	reactome/R-HSA-5693608.md	Initial resection of double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	96	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	97	R-HSA-6799332	ATR phosphorylates TP53	yes	reactome/R-HSA-6799332.md	ATR phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	98	R-HSA-69891	Phosphorylation and activation of CHEK2 by ATM	yes	reactome/R-HSA-69891.md	Phosphorylation and activation of CHEK2 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	99	R-HSA-9663194	Some pathogenic BRCA1 mutants do not bind BARD1	yes	reactome/R-HSA-9663194.md	Some pathogenic BRCA1 mutants do not bind BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	100	R-HSA-9699163	Defective BARD1 does not bind BRCA1	yes	reactome/R-HSA-9699163.md	Defective BARD1 does not bind BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	101	R-HSA-9700998	BAP1 disrupts the BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9700998.md	BAP1 disrupts the BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	102	R-HSA-9701000	BRCA1:BARD1 heterodimer autoubiquitinates	yes	reactome/R-HSA-9701000.md	BRCA1:BARD1 heterodimer autoubiquitinates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	103	R-HSA-9701003	BAP1 binds BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9701003.md	BAP1 binds BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	104	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	105	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	106	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	107	R-HSA-9707051	UBXN1 binds BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9707051.md	UBXN1 binds BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	108	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	109	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	110	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	111	R-HSA-9980006	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	yes	reactome/R-HSA-9980006.md	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BARD1	genes/human/BARD1/BARD1-ai-review.yaml	BARD1	Q99728	NCBITaxon:9606	Homo sapiens	112	R-HSA-9980021	LIG1 binds SSA sites	yes	reactome/R-HSA-9980021.md	LIG1 binds SSA sites	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BARD1 is localized to the nucleoplasm in the curated repair context.
human	BBIP1	genes/human/BBIP1/BBIP1-ai-review.yaml	BBIP1	A8MTZ0	NCBITaxon:9606	Homo sapiens	10	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the BBSome (and thus BBIP1) in the cytosol during pathway steps prior to ciliary entry. Consistent with cytoplasmic localization but less specific than the BBSome/ciliary CCs.
human	BBIP1	genes/human/BBIP1/BBIP1-ai-review.yaml	BBIP1	A8MTZ0	NCBITaxon:9606	Homo sapiens	11	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol localization from the Reactome Formation of the BBSome reaction.
human	BBIP1	genes/human/BBIP1/BBIP1-ai-review.yaml	BBIP1	A8MTZ0	NCBITaxon:9606	Homo sapiens	12	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol localization from a Reactome BBSome cargo-binding reaction.
human	BBIP1	genes/human/BBIP1/BBIP1-ai-review.yaml	BBIP1	A8MTZ0	NCBITaxon:9606	Homo sapiens	13	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol localization from a Reactome BBSome cargo-targeting reaction.
human	BBIP1	genes/human/BBIP1/BBIP1-ai-review.yaml	BBIP1	A8MTZ0	NCBITaxon:9606	Homo sapiens	14	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol localization from the Reactome LZTFL1-BBSome reaction.
human	BBS1	genes/human/BBS1/BBS1-ai-review.yaml	BBS1	Q8NFJ9	NCBITaxon:9606	Homo sapiens	38	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the BBSome (BBSome binds RAB3IP step) in the cytosol prior to ciliary recruitment. Consistent with a cytoplasmic/cytosolic pool of the assembled complex.
human	BBS1	genes/human/BBS1/BBS1-ai-review.yaml	BBS1	Q8NFJ9	NCBITaxon:9606	Homo sapiens	39	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization for BBSome formation. Consistent with cytoplasmic assembly of the complex.
human	BBS1	genes/human/BBS1/BBS1-ai-review.yaml	BBS1	Q8NFJ9	NCBITaxon:9606	Homo sapiens	40	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization (ARL6:GTP and BBSome bind ciliary cargo). Accept as a supported localization step.
human	BBS1	genes/human/BBS1/BBS1-ai-review.yaml	BBS1	Q8NFJ9	NCBITaxon:9606	Homo sapiens	41	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization (cargo targeting to cilium). Accept as a supported step.
human	BBS1	genes/human/BBS1/BBS1-ai-review.yaml	BBS1	Q8NFJ9	NCBITaxon:9606	Homo sapiens	42	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization (LZTFL1 binds BBSome, preventing premature ciliary traffic). Consistent with cytosolic regulation of BBSome ciliary entry.
human	BBS2	genes/human/BBS2/BBS2-ai-review.yaml	BBS2	Q9BXC9	NCBITaxon:9606	Homo sapiens	34	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (BBSome binds RAB3IP/Rabin8). Consistent with the cytoplasmic pool of the BBSome.
human	BBS2	genes/human/BBS2/BBS2-ai-review.yaml	BBS2	Q9BXC9	NCBITaxon:9606	Homo sapiens	35	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (Formation of the BBSome).
human	BBS2	genes/human/BBS2/BBS2-ai-review.yaml	BBS2	Q9BXC9	NCBITaxon:9606	Homo sapiens	36	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (ARL6:GTP and the BBSome bind ciliary cargo).
human	BBS2	genes/human/BBS2/BBS2-ai-review.yaml	BBS2	Q9BXC9	NCBITaxon:9606	Homo sapiens	37	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (ARL6:GTP and the BBSome target cargo to the cilium).
human	BBS2	genes/human/BBS2/BBS2-ai-review.yaml	BBS2	Q9BXC9	NCBITaxon:9606	Homo sapiens	38	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (LZTFL1 binds the BBSome).
human	BBS4	genes/human/BBS4/BBS4-ai-review.yaml	BBS4	Q96RK4	NCBITaxon:9606	Homo sapiens	42	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation for the BBSome-binds-RAB3IP reaction. Cytosolic pool exists but the cilium/centrosome locations are the functionally informative ones.
human	BBS4	genes/human/BBS4/BBS4-ai-review.yaml	BBS4	Q96RK4	NCBITaxon:9606	Homo sapiens	43	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation for BBSome formation reaction.
human	BBS4	genes/human/BBS4/BBS4-ai-review.yaml	BBS4	Q96RK4	NCBITaxon:9606	Homo sapiens	44	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation for ARL6:GTP/BBSome cargo-binding reaction.
human	BBS4	genes/human/BBS4/BBS4-ai-review.yaml	BBS4	Q96RK4	NCBITaxon:9606	Homo sapiens	45	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation for ARL6:GTP/BBSome cargo-targeting reaction.
human	BBS4	genes/human/BBS4/BBS4-ai-review.yaml	BBS4	Q96RK4	NCBITaxon:9606	Homo sapiens	46	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation for the LZTFL1-binds-BBSome reaction.
human	BBS5	genes/human/BBS5/BBS5-ai-review.yaml	BBS5	Q8N3I7	NCBITaxon:9606	Homo sapiens	20	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-asserted cytosolic localization within the BBSome cargo-targeting pathway. The BBSome cycles through the cytosol; correct but non-core relative to the ciliary localizations.
human	BBS5	genes/human/BBS5/BBS5-ai-review.yaml	BBS5	Q8N3I7	NCBITaxon:9606	Homo sapiens	21	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (BBSome formation). Redundant with the other cytosol annotations; correct but non-core.
human	BBS5	genes/human/BBS5/BBS5-ai-review.yaml	BBS5	Q8N3I7	NCBITaxon:9606	Homo sapiens	22	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (ARL6:GTP/BBSome cargo binding). Redundant; correct but non-core.
human	BBS5	genes/human/BBS5/BBS5-ai-review.yaml	BBS5	Q8N3I7	NCBITaxon:9606	Homo sapiens	23	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (cargo targeting to cilium). Redundant; correct but non-core.
human	BBS5	genes/human/BBS5/BBS5-ai-review.yaml	BBS5	Q8N3I7	NCBITaxon:9606	Homo sapiens	24	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (LZTFL1/BBSome). Redundant; correct but non-core.
human	BBS7	genes/human/BBS7/BBS7-ai-review.yaml	BBS7	Q8IWZ6	NCBITaxon:9606	Homo sapiens	23	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the cytosolic BBSome (binding RAB3IP/Rabin8) in the cytosol. Correct but generic relative to the centriolar satellite and centrosome locations.
human	BBS7	genes/human/BBS7/BBS7-ai-review.yaml	BBS7	Q8IWZ6	NCBITaxon:9606	Homo sapiens	24	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Formation of the BBSome places BBS7 in the cytosol during assembly. Correct but generic.
human	BBS7	genes/human/BBS7/BBS7-ai-review.yaml	BBS7	Q8IWZ6	NCBITaxon:9606	Homo sapiens	25	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (ARL6-GTP and BBSome bind ciliary cargo) places BBS7 in the cytosol. Correct but generic.
human	BBS7	genes/human/BBS7/BBS7-ai-review.yaml	BBS7	Q8IWZ6	NCBITaxon:9606	Homo sapiens	26	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (ARL6-GTP and BBSome target cargo to cilium) places BBS7 in the cytosol. Correct but generic.
human	BBS7	genes/human/BBS7/BBS7-ai-review.yaml	BBS7	Q8IWZ6	NCBITaxon:9606	Homo sapiens	27	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (LZTFL1 binds BBSome and prevents ciliary traffic) places BBS7 in the cytosol. Correct but generic.
human	BBS9	genes/human/BBS9/BBS9-ai-review.yaml	BBS9	Q3SYG4	NCBITaxon:9606	Homo sapiens	24	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ""cytosol"" from a Reactome reaction (BBSome binds RAB3IP/Rabin8). Reflects the cytosolic pool of the BBSome before/around ciliary docking. General location term."
human	BBS9	genes/human/BBS9/BBS9-ai-review.yaml	BBS9	Q3SYG4	NCBITaxon:9606	Homo sapiens	25	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ""cytosol"" from the Reactome ""Formation of the BBSome"" reaction. General location term reflecting cytosolic BBSome assembly."
human	BBS9	genes/human/BBS9/BBS9-ai-review.yaml	BBS9	Q3SYG4	NCBITaxon:9606	Homo sapiens	26	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ""cytosol"" from the Reactome ""ARL6:GTP and the BBSome bind ciliary cargo"" reaction. General location term."
human	BBS9	genes/human/BBS9/BBS9-ai-review.yaml	BBS9	Q3SYG4	NCBITaxon:9606	Homo sapiens	27	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ""cytosol"" from the Reactome ""ARL6:GTP and the BBSome target cargo to the primary cilium"" reaction. General location term."
human	BBS9	genes/human/BBS9/BBS9-ai-review.yaml	BBS9	Q3SYG4	NCBITaxon:9606	Homo sapiens	28	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ""cytosol"" from the Reactome ""LZTFL1 binds the BBSome and prevents its traffic to the cilium"" reaction. General location term."
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	31	R-HSA-8951499	Loading of antigenic peptides on to class I MHC	yes	reactome/R-HSA-8951499.md	Loading of antigenic peptides on to class I MHC	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation relating to MHC class I peptide loading. BCAP31 has a short lumenal N-terminus but most of the protein is cytosolic. This specific localization relates to its role in peptide loading complex.
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	32	R-HSA-983138	Transport of MHC heterotrimer to ER exit site	yes	reactome/R-HSA-983138.md	Transport of MHC heterotrimer to ER exit site	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MHC transport. Duplicate evidence for same localization.
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	33	R-HSA-983142	Formation of peptide loading complex (PLC)	yes	reactome/R-HSA-983142.md	Formation of peptide loading complex (PLC)	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Peptide loading complex formation in Reactome.
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	34	R-HSA-983161	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex	yes	reactome/R-HSA-983161.md	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Dissociation of peptide loading complex annotation.
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	37	R-HSA-9837136	SH binds to BCAP31	yes	reactome/R-HSA-9837136.md	SH binds to BCAP31	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RSV SH binding to BCAP31 at ER membrane.
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	48	R-HSA-351894	Caspase mediated cleavage of BAP31	yes	reactome/R-HSA-351894.md	Caspase mediated cleavage of BAP31	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"This Reactome annotation is for ""Caspase mediated cleavage of BAP31"". The cytosolic annotation likely refers to the cytosolic domain of BCAP31 or the released p20 fragment after caspase cleavage."
human	BCAP31	genes/human/BCAP31/BCAP31-ai-review.yaml	BCAP31	P51572	NCBITaxon:9606	Homo sapiens	49	R-HSA-351894	Caspase mediated cleavage of BAP31	yes	reactome/R-HSA-351894.md	Caspase mediated cleavage of BAP31	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for caspase cleavage context - BCAP31 at ER membrane.
human	BCAT2	genes/human/BCAT2/BCAT2-ai-review.yaml	BCAT2	O15382	NCBITaxon:9606	Homo sapiens	34	R-HSA-508179	a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the BCAT2 reaction in the mitochondrial matrix (reverse direction: keto acids + glutamate to BCAAs + alpha-ketoglutarate).
human	BCAT2	genes/human/BCAT2/BCAT2-ai-review.yaml	BCAT2	O15382	NCBITaxon:9606	Homo sapiens	35	R-HSA-70724	leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate,	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the BCAT2 reaction in the mitochondrial matrix (forward catabolic direction: BCAAs + alpha-ketoglutarate to keto acids + glutamate).
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865121	BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of the BCKDH reaction to the mitochondrial matrix. Correct and consistent with all other localization evidence.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	26	R-HSA-5693148	BCKDK phosphorylates BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct and consistent with all other localization evidence.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	27	R-HSA-5693153	PPM1K dephosphorylates p-BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct; duplicate of the well-supported matrix localization.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	28	R-HSA-9859148	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix (BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV reaction). Correct localization of the E1-catalyzed step.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	29	R-HSA-9859163	DBT transfers BCAA to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct; consistent with all other localization evidence.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	30	R-HSA-9859172	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix (DLD dimer dehydrogenates dihydrolipoyl step of the BCKDH complex). Correct localization; annotated to E1-alpha as part of the same complex.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	31	R-HSA-9865115	DBT loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct; consistent duplicate of the matrix localization.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	32	R-HSA-9907572	Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct; consistent duplicate of the matrix localization.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	33	R-HSA-9912480	BCKDK loss-of-function mutations do not phosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix. Correct; consistent duplicate of the matrix localization.
human	BCKDHA	genes/human/BCKDHA/BCKDHA-ai-review.yaml	BCKDHA	P12694	NCBITaxon:9606	Homo sapiens	34	R-HSA-9912527	H139Hfs13* PPM1K does not dephosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial matrix (H139Hfs13* PPM1K does not dephosphorylate BCKDH). Correct localization of the regulated BCKDH reaction.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	23	R-HSA-9865121	BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization annotation from a curated pathway reaction involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	30	R-HSA-5693148	BCKDK phosphorylates BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated pathway reaction involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	31	R-HSA-5693153	PPM1K dephosphorylates p-BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated pathway reaction involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	32	R-HSA-9912527	H139Hfs13* PPM1K does not dephosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated pathway reaction (BCKDH dephosphorylation by PPM1K) involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	34	R-HSA-9859148	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from the curated reaction in which the BCKDHA:BCKDHB E1 tetramer decarboxylates KIC, KMV and KIV.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	35	R-HSA-9859163	DBT transfers BCAA to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated pathway reaction involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	36	R-HSA-9859172	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from the curated reaction in which the DLD (E3) dimer dehydrogenates dihydrolipoyl, part of the BCKDH complex cycle.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	37	R-HSA-9865115	DBT loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated reaction involving DBT (E2) loss-of-function within the BCKDH pathway.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	38	R-HSA-9907572	Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from a curated pathway reaction involving the BCKDH complex.
human	BCKDHB	genes/human/BCKDHB/BCKDHB-ai-review.yaml	BCKDHB	P21953	NCBITaxon:9606	Homo sapiens	39	R-HSA-9912480	BCKDK loss-of-function mutations do not phosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization from the curated reaction in which BCKDK loss-of-function mutations fail to phosphorylate BCKDH.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	119	R-HSA-114352	BCL2 sequestration of tBID	yes	reactome/R-HSA-114352.md	Sequestration of tBID by BCL-2	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BCL2 sequestration of tBID at OMM.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	120	R-HSA-139897	BAD displacing tBID from BCL2	yes	reactome/R-HSA-139897.md	BAD displaces tBID from BCL-2 sequestration	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BAD displacing tBID from BCL2.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	121	R-HSA-508163	BH3-only proteins inactivating BCL2	yes	reactome/R-HSA-508163.md	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BH3-only proteins inactivating BCL2.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	122	R-HSA-6790025	BCL2 expression	yes	reactome/R-HSA-6790025.md	Expression of BCL2, BCL2L1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BCL2 expression.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	123	R-HSA-879201	BCL2 binding NLRP1	yes	reactome/R-HSA-879201.md	Bcl-2 and Bcl-XL bind NLRP1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BCL2 binding NLRP1.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	124	R-HSA-9011941	Estrogen-responsive BCL2 expression	yes	reactome/R-HSA-9011941.md	Estrogen-responsive BCL2 gene expression	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for estrogen-responsive BCL2 expression.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	125	R-HSA-9623999	BCL2 expression downstream of ESR1	yes	reactome/R-HSA-9623999.md	BCL gene expression downstream of ESR1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BCL2 expression downstream of ESR1.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	126	R-HSA-9692376	BCL2 binding antagonists	yes	reactome/R-HSA-9692376.md	BCL2 binds BCL2 antagonists	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for BCL2 binding antagonists.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	127	R-HSA-9796055	NFE2L2-dependent BCL2 expression	yes	reactome/R-HSA-9796055.md	NFE2L2 dependent BCL2 expression	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NFE2L2-dependent BCL2 expression.
human	BCL2	genes/human/BCL2/BCL2-ai-review.yaml	BCL2	P10415	NCBITaxon:9606	Homo sapiens	128	R-HSA-9824587	MITF-dependent BCL2 expression	yes	reactome/R-HSA-9824587.md	MITF-M-dependent BCL2 expression	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for MITF-dependent BCL2 expression.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	66	R-HSA-9698026	FLT3 ITD- and STAT5-dependent BCL2L1 gene expression	yes	reactome/R-HSA-9698026.md	FLT3 ITD- and STAT5-dependent BCL2L1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosol annotation. Consistent with IEA annotation.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	67	R-HSA-9704655	SARS-CoV-1 E binds BCL2L1	yes	reactome/R-HSA-9704655.md	SARS-CoV-1 E binds BCL2L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosol annotation. Duplicate.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	68	R-HSA-9704692	SARS-CoV-1 7a binds BCL2L1	yes	reactome/R-HSA-9704692.md	SARS-CoV-1 7a binds BCL2L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosol annotation. Duplicate.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	69	R-HSA-9796043	NFE2L2 dependent BCL2L1 expression	yes	reactome/R-HSA-9796043.md	NFE2L2 dependent BCL2L1 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosol annotation. Duplicate.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	77	R-HSA-508162	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL	yes	reactome/R-HSA-508162.md	BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived MOM annotation. Core localization.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	78	R-HSA-6790025	Expression of BCL2, BCL2L1	yes	reactome/R-HSA-6790025.md	Expression of BCL2, BCL2L1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived MOM annotation. Duplicate.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	79	R-HSA-879201	Bcl-2 and Bcl-XL bind NLRP1	yes	reactome/R-HSA-879201.md	Bcl-2 and Bcl-XL bind NLRP1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived MOM annotation. Duplicate.
human	BCL2L1	genes/human/BCL2L1/BCL2L1-ai-review.yaml	BCL2L1	Q07817	NCBITaxon:9606	Homo sapiens	80	R-HSA-9653595	pS181-S-Farn-Me KRAS4B binds BCL2L1	yes	reactome/R-HSA-9653595.md	pS181-S-Farn-Me KRAS4B binds BCL2L1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived MOM annotation. Duplicate.
human	BDH1	genes/human/BDH1/BDH1-ai-review.yaml	BDH1	Q02338	NCBITaxon:9606	Homo sapiens	13	R-HSA-73912	acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS location (matrix) associated with the ketogenesis-direction reaction (acetoacetate + NADH -> beta-hydroxybutyrate + NAD+). The location statement is consistent with the enzyme's matrix-facing activity.
human	BDH1	genes/human/BDH1/BDH1-ai-review.yaml	BDH1	Q02338	NCBITaxon:9606	Homo sapiens	14	R-HSA-73920	D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS location (matrix) associated with the ketolysis-direction reaction (beta-hydroxybutyrate + NAD+ -> acetoacetate + NADH). Consistent with the matrix-facing activity of the enzyme.
human	BDH1	genes/human/BDH1/BDH1-ai-review.yaml	BDH1	Q02338	NCBITaxon:9606	Homo sapiens	15	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS location (matrix) arising from the generic reaction ""CLPXP binds mitochondrial matrix proteins"", in which BDH1 is one of many matrix proteins engaged by the CLPXP quality- control protease. The location assignment is correct, but this reflects BDH1 being a protease substrate, not a BDH1-specific function."
human	BDH1	genes/human/BDH1/BDH1-ai-review.yaml	BDH1	Q02338	NCBITaxon:9606	Homo sapiens	16	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS location (matrix) arising from the generic reaction ""CLPXP degrades mitochondrial matrix proteins"", where BDH1 is a substrate of the CLPXP protease. The location is correct but reflects generic proteostasis, not a BDH1-specific role."
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	118	R-HSA-9837231	ISGylation of BECN1	yes	reactome/R-HSA-9837231.md	ISGylation of BECN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ISGylation of BECN1 in cytosol.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	155	R-HSA-6781779	USP13 deubiquitinates BECN1	yes	reactome/R-HSA-6781779.md	USP13 deubiquitinates BECN1,USP10	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	USP13 deubiquitinates BECN1 in cytosol.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	162	R-HSA-5672012	Beclin-1 complex phosphorylates PtdIns	yes	reactome/R-HSA-5672012.md	Beclin-1 complex phosphorylates PtdIns	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Beclin-1 complex phosphorylates PtdIns in cytosol.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	163	R-HSA-5679205	ULK1 phosphorylates Beclin-1	yes	reactome/R-HSA-5679205.md	ULK1 phosphorylates Beclin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 phosphorylates Beclin-1 in cytosol.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	164	R-HSA-5682385	Phagophore extends from PI3P-enriched structure	yes	reactome/R-HSA-5682385.md	The phagophore extends from the PIP3-enriched structure	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Phagophore extends from PI3P-enriched structure.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	179	R-HSA-1169406	ISGylation of host proteins	yes	reactome/R-HSA-1169406.md	ISGylation of host proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ISGylation of host proteins in cytosol.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	180	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 phosphorylates AMBRA1:BECN1 complex.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	181	R-HSA-1678841	USP18 regulation	yes	reactome/R-HSA-1678841.md	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ISG15 deconjugating enzyme USP18 regulation.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	182	R-HSA-5678313	AMBRA1:DYNLL binds BECN1 complex	yes	reactome/R-HSA-5678313.md	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AMBRA1:DYNLL binds BECN1 complex.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	183	R-HSA-5678315	BECN1 complex dissociates from DYNLL	yes	reactome/R-HSA-5678315.md	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	BECN1 complex dissociates from DYNLL.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	184	R-HSA-5679266	Beclin-1 complex translocates to ER	yes	reactome/R-HSA-5679266.md	Beclin-1 complex translocates to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Beclin-1 complex translocates to ER.
human	BECN1	genes/human/BECN1/BECN1-ai-review.yaml	BECN1	Q14457	NCBITaxon:9606	Homo sapiens	185	R-HSA-9755359	SARS-CoV-2 ORF8 binds BECN1	yes	reactome/R-HSA-9755359.md	SARS-CoV-2 8:class I MHC binds BECN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SARS-CoV-2 ORF8:class I MHC binds BECN1.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	81	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	82	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	83	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	84	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	85	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	86	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	87	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	88	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	89	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	90	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	91	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIN1	genes/human/BIN1/BIN1-ai-review.yaml	BIN1	O00499	NCBITaxon:9606	Homo sapiens	92	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This location or process is consistent with BIN1 membrane-remodeling and endocytic adaptor function in neuronal and muscle contexts.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	69	R-HSA-8956026	Reactome pathway annotation	yes	reactome/R-HSA-8956026.md	CUL9:RBX1 ubiquitinates BIRC5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for cytosolic localization.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	70	R-HSA-4655355	SUMOylation of the CPC	yes	reactome/R-HSA-4655355.md	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for nucleoplasm localization.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	71	R-HSA-6790036	Reactome mitosis pathway	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation - duplicate.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	72	R-HSA-6797763	TP53 regulation of BIRC5	yes	reactome/R-HSA-6797763.md	TP53 inhibits BIRC5 expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TP53-BIRC5 regulation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	74	R-HSA-141409	Spindle checkpoint signaling	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for spindle checkpoint pathway.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	75	R-HSA-141422	Spindle checkpoint	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome spindle checkpoint annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	76	R-HSA-141431	Spindle checkpoint pathway	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome spindle checkpoint annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	77	R-HSA-141439	Spindle checkpoint signaling	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome spindle checkpoint annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	78	R-HSA-1638803	Cohesin phosphorylation	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cohesin phosphorylation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	79	R-HSA-1638821	Mitotic pathway	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	80	R-HSA-2467809	Separase/cohesin cleavage	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for separase/cohesin cleavage.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	81	R-HSA-2467811	Sister chromatid separation	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for sister chromatid separation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	82	R-HSA-2468287	CDK1 phosphorylation of sororin	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CDK1 phosphorylation of sororin.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	83	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kinetochore assembly.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	84	R-HSA-375302	Kinetochore capture	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kinetochore capture.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	85	R-HSA-4655355	SUMOylation of the CPC	yes	reactome/R-HSA-4655355.md	RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CPC SUMOylation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	86	R-HSA-5666129	Mitosis pathway	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	87	R-HSA-5666160	Cell cycle pathway	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	88	R-HSA-5666169	Mitotic pathway	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation.
human	BIRC5	genes/human/BIRC5/BIRC5-ai-review.yaml	BIRC5	O15392	NCBITaxon:9606	Homo sapiens	89	R-HSA-9648114	Mitotic spindle pathway	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for mitotic spindle.
human	BIRC6	genes/human/BIRC6/BIRC6-ai-review.yaml	BIRC6	Q9NR09	NCBITaxon:9606	Homo sapiens	29	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome pathway R-HSA-9700131 (ALK mutants bind type I TKIs) seems unrelated to BIRC6's primary biology. However, BIRC6 is a cytoplasmic/cytosolic protein that functions in the cytoplasm. Cytosol localization is reasonable given the protein's known distribution.
human	BLVRA	genes/human/BLVRA/BLVRA-ai-review.yaml	BLVRA	P53004	NCBITaxon:9606	Homo sapiens	31	R-HSA-189384	BLVRA:Zn2+, BLVRB reduce BV to BIL	yes	reactome/R-HSA-189384.md	BLVRA:Zn2+, BLVRB reduce BV to BIL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the BLVRA-catalyzed biliverdin-to-bilirubin reaction in the cytosol. Consistent with experimental localization; accepted.
human	BLVRB	genes/human/BLVRB/BLVRB-ai-review.yaml	BLVRB	P30043	NCBITaxon:9606	Homo sapiens	25	R-HSA-189384	BLVRA:Zn2+, BLVRB reduce BV to BIL	yes	reactome/R-HSA-189384.md	BLVRA:Zn2+, BLVRB reduce BV to BIL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) placement of BLVRB in the cytosol as part of the biliverdin-to-bilirubin reduction reaction. Accurate compartment for this soluble reductase.
human	BNIP3L	genes/human/BNIP3L/BNIP3L-ai-review.yaml	BNIP3L	O60238	NCBITaxon:9606	Homo sapiens	47	R-HSA-6798004	TP53 stimulates BNIP3L expression	yes	reactome/R-HSA-6798004.md	TP53 stimulates BNIP3L expression	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated mitochondrial outer membrane localization (TP53 stimulates BNIP3L expression pathway).
human	BNIP3L	genes/human/BNIP3L/BNIP3L-ai-review.yaml	BNIP3L	O60238	NCBITaxon:9606	Homo sapiens	48	R-HSA-6801195	STEAP3 binds BNIP3L	yes	reactome/R-HSA-6801195.md	STEAP3 binds BNIP3L	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated mitochondrial outer membrane localization (STEAP3 binds BNIP3L pathway).
human	BPGM	genes/human/BPGM/BPGM-ai-review.yaml	BPGM	P07738	NCBITaxon:9606	Homo sapiens	11	R-HSA-6798335	BPGM dimer isomerises 1,3BPG to 2,3BPG	yes	reactome/R-HSA-6798335.md	BPGM dimer isomerises 1,3BPG to 2,3BPG	Homo sapiens	GO:1901136	carbohydrate derivative catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-traceable involvement in a carbohydrate-derivative catabolic process, reflecting BPGM consuming/isomerising the sugar-phosphate 1,3-bisphosphoglycerate (and the phosphatase breakdown of 2,3-BPG) within the Rapoport-Luebering shunt.
human	BPGM	genes/human/BPGM/BPGM-ai-review.yaml	BPGM	P07738	NCBITaxon:9606	Homo sapiens	12	R-HSA-6798335	BPGM dimer isomerises 1,3BPG to 2,3BPG	yes	reactome/R-HSA-6798335.md	BPGM dimer isomerises 1,3BPG to 2,3BPG	Homo sapiens	GO:0004082	bisphosphoglycerate mutase activity	TAS	enables	MF	false		ACCEPT	Reactome-traceable assertion of bisphosphoglycerate mutase activity (isomerisation of 1,3-BPG to 2,3-BPG). This is the core molecular function of BPGM.
human	BPGM	genes/human/BPGM/BPGM-ai-review.yaml	BPGM	P07738	NCBITaxon:9606	Homo sapiens	13	R-HSA-6798335	BPGM dimer isomerises 1,3BPG to 2,3BPG	yes	reactome/R-HSA-6798335.md	BPGM dimer isomerises 1,3BPG to 2,3BPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-traceable cytosolic localization, consistent with the soluble erythrocyte Rapoport-Luebering shunt.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	76	R-HSA-5672950	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	yes	reactome/R-HSA-5672950.md	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	77	R-HSA-5672951	Inactive RAFs bind YWHAB	yes	reactome/R-HSA-5672951.md	Inactive RAFs bind YWHAB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	78	R-HSA-5672960	YWHAB dimer dissociates from dephosphorylated RAF	yes	reactome/R-HSA-5672960.md	YWHAB dimer dissociates from dephosphorylated RAF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	79	R-HSA-5672961	PP2A dephosphorylates inactive RAFs	yes	reactome/R-HSA-5672961.md	PP2A dephosphorylates inactive RAFs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	80	R-HSA-5672966	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	yes	reactome/R-HSA-5672966.md	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	81	R-HSA-5672969	Phosphorylation of RAF	yes	reactome/R-HSA-5672969.md	Phosphorylation of RAF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	82	R-HSA-5672972	MAP2Ks and MAPKs bind to the activated RAF complex	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	83	R-HSA-5672973	MAP2Ks phosphorylate MAPKs	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	84	R-HSA-5672978	RAF phosphorylates MAP2K dimer	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	85	R-HSA-5672980	Dissociation of RAS:RAF complex	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	86	R-HSA-5674130	MAP2Ks and MAPKs are phosphorylated at the endosome membrane	yes	reactome/R-HSA-5674130.md	MAP2Ks and MAPKs are phosphorylated at the endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	87	R-HSA-5674132	WDR83:LAMTOR2:LAMTOR3 binds MAPK components	yes	reactome/R-HSA-5674132.md	WDR83:LAMTOR2:LAMTOR3 binds MAPK components	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	88	R-HSA-5674140	PAQR3 binds inactive RAFs	yes	reactome/R-HSA-5674140.md	PAQR3 binds inactive RAFs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	89	R-HSA-5675417	PEBP1 binds activated RAF1	yes	reactome/R-HSA-5675417.md	PEBP1 binds activated RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	90	R-HSA-5675431	PP2A dephosphorylates RAF1	yes	reactome/R-HSA-5675431.md	PP2A dephosphorylates RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	91	R-HSA-5675433	PP5 dephosphorylates RAF1 S338	yes	reactome/R-HSA-5675433.md	PP5 dephosphorylates RAF1 S338	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	92	R-HSA-6802924	RAF is phosphorylated downstream of oncogenic RAS	yes	reactome/R-HSA-6802924.md	RAF is phosphorylated downstream of oncogenic RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	93	R-HSA-6803240	Homo- or heterodimerization of RAF downstream of mutant RAS	yes	reactome/R-HSA-6803240.md	Homo- or heterodimerization of RAF downstream of mutant RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	94	R-HSA-9610152	Activated BRAF recruits MAP2Ks and MAPKs to the endosome	yes	reactome/R-HSA-9610152.md	Activated BRAF recruits MAP2Ks and MAPKs to the endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	95	R-HSA-9610153	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF	yes	reactome/R-HSA-9610153.md	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	96	R-HSA-9610154	Dissociation of phosphorylated MAP2Ks and MAPKs	yes	reactome/R-HSA-9610154.md	Dissociation of phosphorylated MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	97	R-HSA-9610156	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF	yes	reactome/R-HSA-9610156.md	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	98	R-HSA-9610163	BRAF autophosphorylates downstream of RAP1 and NGF	yes	reactome/R-HSA-9610163.md	BRAF autophosphorylates downstream of RAP1 and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	99	R-HSA-9653108	Raf dimer inhibitors bind RAF heterodimers	yes	reactome/R-HSA-9653108.md	Raf dimer inhibitors bind RAF heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	100	R-HSA-9656209	Dissociation of RAS:RAF1 mutant complex	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	101	R-HSA-9656211	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	102	R-HSA-9656212	Phosphorylation of RAF1 mutants	yes	reactome/R-HSA-9656212.md	Phosphorylation of RAF1 mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	103	R-HSA-9656213	RAF1 mutants show enhanced heterodimerization with BRAF	yes	reactome/R-HSA-9656213.md	RAF1 mutants show enhanced heterodimerization with BRAF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	104	R-HSA-9656214	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	105	R-HSA-9656215	RAF1 mutant complexes phosphorylate MAP2K dimer	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	106	R-HSA-9657599	Dual mechanism MAP2K inhibitors bind MAP2Ks	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	107	R-HSA-9657603	Dual mechanism MAPK inhibitors bind MAPKs	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	108	R-HSA-9657606	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	109	R-HSA-9657608	Single mechanism MAPK inhibitors bind phosphorylated MAPK	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	110	R-HSA-9658445	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs	yes	reactome/R-HSA-9658445.md	MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	111	R-HSA-9660536	SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex	yes	reactome/R-HSA-9660536.md	SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	112	R-HSA-9660538	Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs	yes	reactome/R-HSA-9660538.md	Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	113	R-HSA-5675198	Activated MAPKs phosphorylate BRAF	yes	reactome/R-HSA-5675198.md	Activated MAPKs phosphorylate BRAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	114	R-HSA-6802908	RAS mutants bind inactive RAF	yes	reactome/R-HSA-6802908.md	RAS mutants bind inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	115	R-HSA-6802922	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	116	R-HSA-6802924	RAF is phosphorylated downstream of oncogenic RAS	yes	reactome/R-HSA-6802924.md	RAF is phosphorylated downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	117	R-HSA-6802925	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	118	R-HSA-6802926	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	119	R-HSA-6803233	Dissociation of oncogenic RAS:RAF complex	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	120	R-HSA-6803240	Homo- or heterodimerization of RAF downstream of mutant RAS	yes	reactome/R-HSA-6803240.md	Homo- or heterodimerization of RAF downstream of mutant RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	121	R-HSA-6802910	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants	yes	reactome/R-HSA-6802910.md	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	122	R-HSA-6802911	High kinase activity BRAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802911.md	High kinase activity BRAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	123	R-HSA-6802912	High kinase activity BRAF mutants bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802912.md	High kinase activity BRAF mutants bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	124	R-HSA-6802930	Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance	yes	reactome/R-HSA-6802930.md	Dimerization of BRAF V600E splice variants contributes to BRAF inhibitor resistance	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	125	R-HSA-6802938	Inhibitors bind and inhibit highly active BRAF mutants	yes	reactome/R-HSA-6802938.md	Inhibitors bind and inhibit highly active BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	126	R-HSA-6803227	Dissociation of high activity BRAF complexes	yes	reactome/R-HSA-6803227.md	Dissociation of high activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	137	R-HSA-6802914	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	138	R-HSA-6802915	Moderate kinase activity BRAF mutants bind RAS:GTP	yes	reactome/R-HSA-6802915.md	Moderate kinase activity BRAF mutants bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	139	R-HSA-6802916	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802916.md	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	140	R-HSA-6802918	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	141	R-HSA-6802919	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	142	R-HSA-6802921	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	143	R-HSA-6802937	Inactive BRAF mutants bind mutant RAS:GTP	yes	reactome/R-HSA-6802937.md	Inactive BRAF mutants bind mutant RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	144	R-HSA-6802941	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	yes	reactome/R-HSA-6802941.md	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	145	R-HSA-6802942	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	146	R-HSA-6802943	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	147	R-HSA-6803230	Dissociation of moderate activity BRAF complexes	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	148	R-HSA-6803234	Dissociation of paradoxically activated RAS:BRAF complexes	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	149	R-HSA-8936676	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	yes	reactome/R-HSA-8936676.md	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	150	R-HSA-8936731	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	yes	reactome/R-HSA-8936731.md	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	151	R-HSA-6802914	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	152	R-HSA-6802916	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802916.md	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	153	R-HSA-6802919	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	154	R-HSA-6802921	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	155	R-HSA-6803230	Dissociation of moderate activity BRAF complexes	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. BRAF is recruited to the plasma membrane via the RBD-RAS-GTP interaction, where it dimerizes (homo- and with CRAF/ARAF) and phosphorylates MEK1/2 in the MAPK cascade.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	159	R-HSA-1295604	B-RAF dissociates from S110/S120 p-SPRY2	yes	reactome/R-HSA-1295604.md	B-RAF dissociates from S110/S120 p-SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRAF	genes/human/BRAF/BRAF-ai-review.yaml	BRAF	P15056	NCBITaxon:9606	Homo sapiens	160	R-HSA-1295634	SPRY2 is serine phosphorylated in response to MAPK activation	yes	reactome/R-HSA-1295634.md	SPRY2 is serine phosphorylated in response to MAPK activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization. BRAF is cytosolic in the autoinhibited (14-3-3-bound) resting state and is recruited to the plasma membrane upon RAS-GTP activation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	47	R-HSA-9701000	BRCA1:BARD1 heterodimer autoubiquitinates	yes	reactome/R-HSA-9701000.md	BRCA1:BARD1 heterodimer autoubiquitinates	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Reactome pathway annotation for BRCA1-BARD1 autoubiquitination activity.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	113	R-HSA-5693606	DNA Double Strand Break Response	yes	reactome/R-HSA-5693606.md	DNA Double Strand Break Response	Homo sapiens	GO:0006302	double-strand break repair	TAS	involved_in	BP	false		ACCEPT	BRCA1 is essential for DNA double-strand break repair via homologous recombination.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	191	R-HSA-5683735	CHEK2 is recruited to DNA DSBs	yes	reactome/R-HSA-5683735.md	CHEK2 is recruited to DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 localizes to nucleoplasm where it performs its DNA repair and checkpoint functions.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	192	R-HSA-5683801	CHEK2 phosphorylates BRCA1	yes	reactome/R-HSA-5683801.md	CHEK2 phosphorylates BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	193	R-HSA-5684052	PIAS4 SUMOylates MDC1	yes	reactome/R-HSA-5684052.md	PIAS4 SUMOylates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	194	R-HSA-5684071	RNF4 ubiquitinates MDC1	yes	reactome/R-HSA-5684071.md	RNF4 ubiquitinates MDC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	195	R-HSA-5684108	BRCA1 binds phosphorylated RBBP8	yes	reactome/R-HSA-5684108.md	BRCA1 binds phosphorylated RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	196	R-HSA-5684875	Binding of ATR:ATRIP to RPA at resected DNA DSBs	yes	reactome/R-HSA-5684875.md	Binding of ATR:ATRIP to RPA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	197	R-HSA-5684882	CHEK1 is recruited to resected DNA DSBs	yes	reactome/R-HSA-5684882.md	CHEK1 is recruited to resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	198	R-HSA-5684887	Activation of CHEK1 at resected DNA DSBs	yes	reactome/R-HSA-5684887.md	Activation of CHEK1 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	199	R-HSA-5685011	ATR activation at DNA DSBs	yes	reactome/R-HSA-5685011.md	ATR activation at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	200	R-HSA-5685156	ATR phosphorylates RPA2	yes	reactome/R-HSA-5685156.md	ATR phosphorylates RPA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	201	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	202	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	203	R-HSA-5685985	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	yes	reactome/R-HSA-5685985.md	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	204	R-HSA-5685994	Long-range resection of DNA DSBs by EXO1 or DNA2	yes	reactome/R-HSA-5685994.md	Long-range resection of DNA DSBs by EXO1 or DNA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	205	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	206	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	207	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	208	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	209	R-HSA-5686642	RAD52 promotes single strand annealing at resected DNA DSBs	yes	reactome/R-HSA-5686642.md	RAD52 promotes single strand annealing at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	210	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	211	R-HSA-5686685	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	yes	reactome/R-HSA-5686685.md	RIF1 and PAX1IP bind TP53BP1 at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	212	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	213	R-HSA-5693542	Association of RPA complexes with ssDNA at resected DNA DSBs	yes	reactome/R-HSA-5693542.md	Association of RPA complexes with ssDNA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	214	R-HSA-5693551	Phosphorylation of BRCA1-A complex at multiple sites by ATM	yes	reactome/R-HSA-5693551.md	Phosphorylation of BRCA1-A complex at multiple sites by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	215	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	216	R-HSA-5693564	Association of RAD51 with RAD52:DNA double-strand break ends	yes	reactome/R-HSA-5693564.md	Association of RAD51 with RAD52:DNA double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	217	R-HSA-5693580	Association of RAD52 with the RPA complex at resected DNA DSBs	yes	reactome/R-HSA-5693580.md	Association of RAD52 with the RPA complex at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	218	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	219	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	220	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	221	R-HSA-5693608	Initial resection of double-strand break ends	yes	reactome/R-HSA-5693608.md	Initial resection of double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	222	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	223	R-HSA-6799332	ATR phosphorylates TP53	yes	reactome/R-HSA-6799332.md	ATR phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	224	R-HSA-69891	Phosphorylation and activation of CHEK2 by ATM	yes	reactome/R-HSA-69891.md	Phosphorylation and activation of CHEK2 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	225	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	226	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	227	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	228	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	229	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	230	R-HSA-2997709	PIAS1,4 SUMOylates BRCA1 with SUMO1	yes	reactome/R-HSA-2997709.md	PIAS1,4 SUMOylates BRCA1 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	231	R-HSA-2997616	PIAS1,4 SUMOylates BRCA1 with SUMO2,3	yes	reactome/R-HSA-2997616.md	PIAS1,4 SUMOylates BRCA1 with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	233	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	234	R-HSA-5683385	Formation of BRCA1-A complex at DNA DSBs	yes	reactome/R-HSA-5683385.md	Formation of BRCA1-A complex at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	235	R-HSA-5691411	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	yes	reactome/R-HSA-5691411.md	BRCA1-A complex deubiquitinates K63polyUb-histone H2A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	236	R-HSA-9701000	BRCA1:BARD1 heterodimer autoubiquitinates	yes	reactome/R-HSA-9701000.md	BRCA1:BARD1 heterodimer autoubiquitinates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	237	R-HSA-9707051	UBXN1 binds BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9707051.md	UBXN1 binds BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	238	R-HSA-9663194	Some pathogenic BRCA1 mutants do not bind BARD1	yes	reactome/R-HSA-9663194.md	Some pathogenic BRCA1 mutants do not bind BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	248	R-HSA-5659781	BRCA1 forms a heterodimer with BARD1	yes	reactome/R-HSA-5659781.md	BRCA1 forms a heterodimer with BARD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	249	R-HSA-6797712	CDK12 stimulates expression of DNA repair genes	yes	reactome/R-HSA-6797712.md	CDK12 stimulates expression of DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	250	R-HSA-9007605	BRCA1 gene expression is inhibited by E2F6	yes	reactome/R-HSA-9007605.md	BRCA1 gene expression is inhibited by E2F6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	251	R-HSA-9699163	Defective BARD1 does not bind BRCA1	yes	reactome/R-HSA-9699163.md	Defective BARD1 does not bind BRCA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	252	R-HSA-9700998	BAP1 disrupts the BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9700998.md	BAP1 disrupts the BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	253	R-HSA-9701003	BAP1 binds BRCA1:BARD1 heterodimer	yes	reactome/R-HSA-9701003.md	BAP1 binds BRCA1:BARD1 heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA1	genes/human/BRCA1/BRCA1-ai-review.yaml	BRCA1	P38398	NCBITaxon:9606	Homo sapiens	254	R-HSA-9926521	MITF-M-dependent BRCA1 gene expression	yes	reactome/R-HSA-9926521.md	MITF-M-dependent BRCA1 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	BRCA1 nucleoplasm localization from Reactome pathway annotation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	107	R-HSA-9763200	BRCA2 mutants do not bind SEM1 (DSS1)	yes	reactome/R-HSA-9763200.md	BRCA2 mutants do not bind SEM1 (DSS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for cytosolic BRCA2.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	108	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	111	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	112	R-HSA-9709268	Defective BRCA2 does not translocate to the nucleus	yes	reactome/R-HSA-9709268.md	Defective BRCA2 does not translocate to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	113	R-HSA-9709273	BRCA2 translocates to the nucleus	yes	reactome/R-HSA-9709273.md	BRCA2 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	114	R-HSA-9763137	BRCA2 binds SEM1 (DSS1)	yes	reactome/R-HSA-9763137.md	BRCA2 binds SEM1 (DSS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway - BRCA2 binds SEM1(DSS1).
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	120	R-HSA-5685242	CHEK1 phosphorylates BRCA2	yes	reactome/R-HSA-5685242.md	CHEK1 phosphorylates BRCA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - CHEK1 phosphorylates BRCA2.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	121	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - BCDX2 complex stabilizes RAD51 filament.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	122	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - CX3 complex binds D-loop.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	123	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - BLM mediates dissolution of double Holliday junction.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	124	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - MUS81:EME1,EME2 cleaves D-loop.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	125	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Resolution of D-loops.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	126	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Resolution of Holliday junctions.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	127	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Ligation of DNA and Holliday structure formation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	128	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - RAD51 binds BRCA2 at resected DSBs.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	129	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Cleavage of Holliday junctions.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	130	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - D-loop dissociation and strand annealing.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	131	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - D-loop extension by DNA polymerases.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	132	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - D-loop formation mediated by PALB2, BRCA2 and RAD51.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	133	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Defective D-loop formation due to BRCA1 loss.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	134	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Defective D-loop formation due to PALB2 loss.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	135	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - Defective D-loop formation.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	136	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - FIGNL1 binds RAD51.
human	BRCA2	genes/human/BRCA2/BRCA2-ai-review.yaml	BRCA2	P51587	NCBITaxon:9606	Homo sapiens	138	R-HSA-9709273	BRCA2 translocates to the nucleus	yes	reactome/R-HSA-9709273.md	BRCA2 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome - BRCA2 translocates to nucleus.
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	49	R-HSA-5684875	Binding of ATR:ATRIP to RPA at resected DNA DSBs	yes	reactome/R-HSA-5684875.md	Binding of ATR:ATRIP to RPA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing BRIP1 in the nucleoplasm within an HR/DSB-response reaction (ATR:ATRIP binding to RPA).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	50	R-HSA-5684882	CHEK1 is recruited to resected DNA DSBs	yes	reactome/R-HSA-5684882.md	CHEK1 is recruited to resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (CHEK1 recruitment reaction).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	51	R-HSA-5684887	Activation of CHEK1 at resected DNA DSBs	yes	reactome/R-HSA-5684887.md	Activation of CHEK1 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (CHEK1 activation reaction).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	52	R-HSA-5685011	ATR activation at DNA DSBs	yes	reactome/R-HSA-5685011.md	ATR activation at DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ATR activation reaction).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	53	R-HSA-5685156	ATR phosphorylates RPA2	yes	reactome/R-HSA-5685156.md	ATR phosphorylates RPA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ATR phosphorylates RPA2).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	54	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (BCDX2 stabilizes RAD51 filament).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	55	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (CX3 complex binds D-loops).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	56	R-HSA-5685985	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	yes	reactome/R-HSA-5685985.md	EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization; this reaction explicitly involves BRIP1 recruitment during long-range DSB resection (EXO1/DNA2 with BLM/WRN).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	57	R-HSA-5685994	Long-range resection of DNA DSBs by EXO1 or DNA2	yes	reactome/R-HSA-5685994.md	Long-range resection of DNA DSBs by EXO1 or DNA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (long-range resection by EXO1/DNA2).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	58	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (BLM double-Holliday-junction dissolution).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	59	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (MUS81:EME1,EME2 cleaves D-loop).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	60	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (resolution of MUS81-cleaved D-loops).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	61	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (resolution of Holliday junctions).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	62	R-HSA-5686642	RAD52 promotes single strand annealing at resected DNA DSBs	yes	reactome/R-HSA-5686642.md	RAD52 promotes single strand annealing at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (RAD52 single-strand annealing).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	63	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ERCC1:XPF cleaves SSA flaps).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	64	R-HSA-5686663	Completion of SSA	yes	reactome/R-HSA-5686663.md	Completion of SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (completion of SSA).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	65	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ligation/Holliday structure formation).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	66	R-HSA-5693542	Association of RPA complexes with ssDNA at resected DNA DSBs	yes	reactome/R-HSA-5693542.md	Association of RPA complexes with ssDNA at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (RPA association with resected ssDNA).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	67	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (RAD51 binds BRCA2 at resected DSBs).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	68	R-HSA-5693564	Association of RAD51 with RAD52:DNA double-strand break ends	yes	reactome/R-HSA-5693564.md	Association of RAD51 with RAD52:DNA double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (RAD51 association with RAD52:DSB ends).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	69	R-HSA-5693580	Association of RAD52 with the RPA complex at resected DNA DSBs	yes	reactome/R-HSA-5693580.md	Association of RAD52 with the RPA complex at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (RAD52 association with RPA complex).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	70	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (Holliday junction cleavage by GEN1/SLX).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	71	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (D-loop dissociation and strand annealing).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	72	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (D-loop extension by DNA polymerases).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	73	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (D-loop formation by PALB2/BRCA2/RAD51).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	74	R-HSA-6799332	ATR phosphorylates TP53	yes	reactome/R-HSA-6799332.md	ATR phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ATR phosphorylates TP53).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	75	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (defective D-loop formation, BRCA1 LoF).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	76	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (defective D-loop formation, PALB2 LoF).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	77	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (defective D-loop formation, PALB2 binding).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	78	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (BRCA2 RAD51-binding mutants).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	79	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (defective BRCA2/RAD51 recruitment).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	80	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (FIGNL1 binds RAD51).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	81	R-HSA-9980006	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	yes	reactome/R-HSA-9980006.md	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (ERCC1:XPF binds SSA intermediates).
human	BRIP1	genes/human/BRIP1/BRIP1-ai-review.yaml	BRIP1	Q9BX63	NCBITaxon:9606	Homo sapiens	82	R-HSA-9980021	LIG1 binds SSA sites	yes	reactome/R-HSA-9980021.md	LIG1 binds SSA sites	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization (LIG1 binds SSA sites).
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	9	R-HSA-196780	Biotin transport and metabolism	yes	reactome/R-HSA-196780.md	Biotin transport and metabolism	Homo sapiens	GO:0006768	biotin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome places biotinidase within biotin transport and metabolism (biotin salvage/recycling); a correct core biological process annotation.
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	10	R-HSA-3076905	Extracellular BTD hydrolyses BCTN	no				GO:0047708	biotinidase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted biotinidase activity for the extracellular hydrolysis of biocytin; the core molecular function.
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	11	R-HSA-3325540	Defective extracellular BTD does not hydrolyse BCTN	no				GO:0047708	biotinidase activity	TAS	enables	MF	false		ACCEPT	"Biotinidase activity annotation from the Reactome ""defective extracellular BTD"" disease reaction; the term is the correct core molecular function (its loss is what defines the disease reaction)."
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	12	R-HSA-4167509	Mitochondrial BTD hydrolyses BCTN	no				GO:0047708	biotinidase activity	TAS	enables	MF	false		ACCEPT	"Biotinidase activity annotation from the Reactome ""mitochondrial BTD hydrolyses BCTN"" reaction; the molecular function is correct and core."
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	13	R-HSA-4225086	Defective mitochondrial BTD does not hydrolyse BCTN	no				GO:0047708	biotinidase activity	TAS	enables	MF	false		ACCEPT	"Biotinidase activity annotation from the Reactome ""defective mitochondrial BTD"" disease reaction; the referenced molecular function is correct and core."
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	14	R-HSA-3325540	Defective extracellular BTD does not hydrolyse BCTN	no				GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome localizes the extracellular biotinidase reaction to the extracellular region; consistent with the secreted enzyme.
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	15	R-HSA-4225086	Defective mitochondrial BTD does not hydrolyse BCTN	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome asserts a mitochondrial pool of biotinidase. This localization is secondary and less well established than the dominant secreted/extracellular form.
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	18	R-HSA-4167509	Mitochondrial BTD hydrolyses BCTN	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome asserts a mitochondrial pool of biotinidase (mitochondrial matrix); secondary and less well established than the secreted form.
human	BTD	genes/human/BTD/BTD-ai-review.yaml	BTD	P43251	NCBITaxon:9606	Homo sapiens	19	R-HSA-3076905	Extracellular BTD hydrolyses BCTN	no				GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome localizes the extracellular biotinidase reaction to the extracellular region; consistent with the secreted enzyme and a core localization.
human	BTN3A3	genes/human/BTN3A3/BTN3A3-ai-review.yaml	BTN3A3	O00478	NCBITaxon:9606	Homo sapiens	10	R-HSA-8851038	BTN3A1 binds prenylated phosphoantigens	yes	reactome/R-HSA-8851038.md	BTN3A1 binds prenylated phosphoantigens	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for BTN3A1 binding prenylated phosphoantigens. This pathway primarily describes BTN3A1, not BTN3A3.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	86	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Mad1 binds kinetochore' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	87	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'MAD2 converted to an inhibitory state via interaction with Mad1' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	88	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Binding of the MCC complex to the APC/C complex' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	89	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'MAD2 associates with the Mad1 kinetochore complex' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	90	R-HSA-141437	Formation of the MCC complex	yes	reactome/R-HSA-141437.md	Formation of the MCC complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Formation of the MCC complex' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	91	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Release of activated MAD2 from kinetochores' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	92	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Phosphorylation of cohesin by PLK1 at centromeres', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	93	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'PP2A-B56 dephosphorylates centromeric cohesin', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	94	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Ubiquitination of Cyclin A by APC/C:Cdc20 complex' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	95	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Association of Cyclin A with the APC/C' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	96	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	97	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Degradation multiubiquitinated Cyclin A' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	98	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Association of Nek2A with MCC:APC/C' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	99	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Multiubiquitination of Nek2A' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	100	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Degradation of multiubiquitinated Nek2A' (mitotic spindle checkpoint / APC/C-MCC pathway); BUB1B participates as a subunit of the cytosolic MCC or APC/C-MCC complex.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	101	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'ESPL1 (Separase) cleaves centromeric cohesin', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	102	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Separation of sister chromatids', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	103	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'CDK1 phosphorylates CDCA5 (Sororin) at centromeres', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	104	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore assembly', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	105	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore capture of astral microtubules', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	106	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'CDC42:GTP recruits DIAPH2-2 to kinetochores', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	107	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'AURKB phosphorylates DIAPH2-2 at kinetochores', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	108	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB1B	genes/human/BUB1B/BUB1B-ai-review.yaml	BUB1B	O60566	NCBITaxon:9606	Homo sapiens	109	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'EML4 recruits NUDC to mitotic spindle', in which BUB1B is carried as a member of a generic Reactome kinetochore/centromere complex entity; the cytosol assignment is the compartment of that entity.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	37	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Mad1 binds kinetochore' (R-HSA-141409). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	38	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'MAD2 converted to an inhibitory state via interaction with Mad1' (R-HSA-141422). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	39	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Binding of the MCC complex to the APC/C complex' (R-HSA-141423), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	40	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'MAD2 associates with the Mad1 kinetochore complex' (R-HSA-141431). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	41	R-HSA-141437	Formation of the MCC complex	yes	reactome/R-HSA-141437.md	Formation of the MCC complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Formation of the MCC complex' (R-HSA-141437), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	42	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Release of activated MAD2 from kinetochores' (R-HSA-141439). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	43	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Phosphorylation of cohesin by PLK1 at centromeres' (R-HSA-1638803). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	44	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'PP2A-B56 dephosphorylates centromeric cohesin' (R-HSA-1638821). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	45	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Ubiquitination of Cyclin A by APC/C:Cdc20 (MCC-bound APC/C pathway)' (R-HSA-174104), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	46	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Association of Cyclin A with the APC/C' (R-HSA-174171), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	47	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Activation of APC/C:Cdc20 by dissociation of Cdc20 from the MCC' (R-HSA-174238), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	48	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Degradation of multiubiquitinated Cyclin A' (R-HSA-174255), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	49	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Association of Nek2A with MCC:APC/C' (R-HSA-179410), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	50	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Multiubiquitination of Nek2A' (R-HSA-179417), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	51	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Degradation of multiubiquitinated Nek2A' (R-HSA-179421), in which BUB3 participates as a subunit of the soluble mitotic checkpoint complex (MCC) or of the MCC-bound APC/C; Reactome places these entities in the cytosol.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	52	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'ESPL1 (Separase) cleaves centromeric cohesin' (R-HSA-2467809). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	53	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Separation of sister chromatids' (R-HSA-2467811). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	54	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'CDK1 phosphorylates CDCA5 (Sororin) at centromeres' (R-HSA-2468287). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	55	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore assembly' (R-HSA-2484822). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	56	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore capture of astral microtubules' (R-HSA-375302). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	57	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'CDC42:GTP recruits DIAPH2-2 to kinetochores' (R-HSA-5666129). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	58	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'AURKB phosphorylates DIAPH2-2 at kinetochores' (R-HSA-5666160). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	59	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'Kinetochore capture of astral microtubules regulated by CDC42:GTP:p-S196-DIAPH2-2' (R-HSA-5666169). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	BUB3	genes/human/BUB3/BUB3-ai-review.yaml	BUB3	O43684	NCBITaxon:9606	Homo sapiens	60	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction 'EML4 recruits NUDC to mitotic spindle' (R-HSA-9648114). BUB3 is not an active participant in this step; it enters the reaction only as a component of Reactome's composite mitotic-kinetochore or checkpoint-complex entity, and the cytosol assignment is that entity's compartment.
human	C1GALT1	genes/human/C1GALT1/C1GALT1-ai-review.yaml	C1GALT1	Q9NS00	NCBITaxon:9606	Homo sapiens	1	R-HSA-1964505	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	yes	reactome/R-HSA-1964505.md	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	"The Golgi membrane is where the T-synthase acts. Reactome's reaction ""C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins"" places the enzyme correctly, and the independent literature refers to it plainly as the Golgi enzyme of this pathway."
human	C1GALT1	genes/human/C1GALT1/C1GALT1-ai-review.yaml	C1GALT1	Q9NS00	NCBITaxon:9606	Homo sapiens	2	R-HSA-6785524	Defective C1GALT1C1 does not bind C1GALT1	yes	reactome/R-HSA-6785524.md	Defective C1GALT1C1 does not bind C1GALT1	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Golgi membrane assignment from a second Reactome reaction. Exact duplicates from different source reactions are expected and unproblematic.
human	C1GALT1C1	genes/human/C1GALT1C1/C1GALT1C1-ai-review.yaml	C1GALT1C1	Q96EU7	NCBITaxon:9606	Homo sapiens	1	R-HSA-1964505	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	yes	reactome/R-HSA-1964505.md	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	Reactome places Cosmc in the Golgi membrane because that is the compartment of the reaction it is modelling (C1GALT1 transferring galactose to the Tn antigen). Cosmc itself is an endoplasmic reticulum protein: it acts co-translationally on nascent T-synthase, and it is the folded client, not the chaperone, that travels on to the Golgi. The compartment assignment has been inherited from the client's site of action.
human	C1GALT1C1	genes/human/C1GALT1C1/C1GALT1C1-ai-review.yaml	C1GALT1C1	Q96EU7	NCBITaxon:9606	Homo sapiens	2	R-HSA-6785524	Defective C1GALT1C1 does not bind C1GALT1	yes	reactome/R-HSA-6785524.md	Defective C1GALT1C1 does not bind C1GALT1	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		MODIFY	"Duplicate Golgi membrane assignment from a second Reactome reaction (""Defective C1GALT1C1 does not bind C1GALT1""). The same reasoning applies: the chaperone acts in the ER, and the Golgi compartment belongs to the client enzyme's reaction rather than to Cosmc."
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	71	R-HSA-9645692	C1QBP promotes translocation of p14ARF to the mitochondrial matrix	yes	reactome/R-HSA-9645692.md	C1QBP promotes translocation of p14ARF to the mitochondrial matrix	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for C1QBP promoting p14ARF translocation to mitochondrial matrix.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	72	R-HSA-9645692	C1QBP promotes translocation of p14ARF to the mitochondrial matrix	yes	reactome/R-HSA-9645692.md	C1QBP promotes translocation of p14ARF to the mitochondrial matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic pool of C1QBP involved in p14ARF pathway.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	73	R-HSA-9645694	p14ARF binds C1QBP	yes	reactome/R-HSA-9645694.md	p14ARF binds C1QBP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	74	R-HSA-9645766	p14ARF mutants do not bind C1QBP	yes	reactome/R-HSA-9645766.md	p14ARF mutants do not bind C1QBP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	78	R-HSA-158218	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer	yes	reactome/R-HSA-158218.md	prekallikrein + kininogen:C1q binding protein tetramer -> prekallikrein:kininogen:C1q binding protein tetramer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kinin pathway at plasma membrane.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	79	R-HSA-158251	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer	yes	reactome/R-HSA-158251.md	prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for kinin pathway.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	80	R-HSA-158311	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin	yes	reactome/R-HSA-158311.md	kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for kinin pathway.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	81	R-HSA-158313	factor XII -> factor XIIa	yes	reactome/R-HSA-158313.md	factor XII -> factor XIIa	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for factor XII activation.
human	C1QBP	genes/human/C1QBP/C1QBP-ai-review.yaml	C1QBP	Q07021	NCBITaxon:9606	Homo sapiens	82	R-HSA-158354	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer	yes	reactome/R-HSA-158354.md	kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kininogen binding.
human	CACNB2	genes/human/CACNB2/CACNB2-ai-review.yaml	CACNB2	Q08289	NCBITaxon:9606	Homo sapiens	36	R-HSA-5577213	LTCC multimer transports Ca2+ from extracellular region to cytosol	yes	reactome/R-HSA-5577213.md	LTCC multimer transports Ca2+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway entry for LTCC multimer transporting calcium from extracellular region to cytosol places CaVbeta2 at the plasma membrane.
human	CACNB2	genes/human/CACNB2/CACNB2-ai-review.yaml	CACNB2	Q08289	NCBITaxon:9606	Homo sapiens	37	R-HSA-9614031	Class IV antihypertensives bind LTCC multimer	yes	reactome/R-HSA-9614031.md	Class IV antihypertensives bind LTCC multimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for Class IV antihypertensives binding LTCC multimer.
human	CACNB3	genes/human/CACNB3/CACNB3-ai-review.yaml	CACNB3	P54284	NCBITaxon:9606	Homo sapiens	20	R-HSA-210420	Ca2+ influx through voltage gated Ca2+ channels	yes	reactome/R-HSA-210420.md	Ca2+ influx through voltage gated Ca2+ channels	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The beta subunit is a cytosolic regulator that associates with intracellular portions of channel alpha subunits.
human	CAD	genes/human/CAD/CAD-ai-review.yaml	CAD	P27708	NCBITaxon:9606	Homo sapiens	71	R-HSA-73571	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO	yes	reactome/R-HSA-73571.md	CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (traceable author statement) placing the DHOase step of CAD in the cytosol.
human	CAD	genes/human/CAD/CAD-ai-review.yaml	CAD	P27708	NCBITaxon:9606	Homo sapiens	72	R-HSA-73573	CAD hexamer transforms CAP to N-carb-L-Asp	yes	reactome/R-HSA-73573.md	CAD hexamer transforms CAP to N-carb-L-Asp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (traceable author statement) placing the ATCase step of CAD in the cytosol.
human	CAD	genes/human/CAD/CAD-ai-review.yaml	CAD	P27708	NCBITaxon:9606	Homo sapiens	73	R-HSA-73577	CAD hexamer transforms L-Gln to CAP	yes	reactome/R-HSA-73577.md	CAD hexamer transforms L-Gln to CAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (traceable author statement) placing the CPS (L-Gln -> carbamoyl phosphate) step of CAD in the cytosol.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	22	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This Reactome annotation for extracellular region derives from the pathway reaction showing calcitonin acting as an extracellular ligand for Gs-activating GPCRs. Calcitonin is a secreted hormone that acts in the extracellular space.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	23	R-HSA-419843	CALCA(83-119) binds CALCR	yes	reactome/R-HSA-419843.md	CALCA(83-119) binds CALCR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This Reactome annotation derives from the reaction CALCA(83-119) binds CALCR, showing calcitonin as an extracellular ligand binding to the calcitonin receptor. Correctly places calcitonin in the extracellular compartment.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	24	R-HSA-744886	The Ligand:GPCR:Gs complex dissociates	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This Reactome annotation from the Ligand:GPCR:Gs complex dissociation pathway places calcitonin in the extracellular region as expected for a secreted hormone ligand.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	25	R-HSA-744887	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This Reactome annotation from the GPCR-Gs binding pathway correctly places calcitonin as an extracellular ligand.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	26	R-HSA-9702354	CALCA(83-119) binds CALCA antibodies	yes	reactome/R-HSA-9702354.md	CALCA(83-119) binds CALCA antibodies	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This Reactome annotation from the reaction CALCA(83-119) binds CALCA antibodies places calcitonin in the extracellular region where it can be bound by therapeutic antibodies.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	27	R-HSA-976734	Amyloid fibrils have additional components	yes	reactome/R-HSA-976734.md	Amyloid fibrils have additional components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This annotation from the amyloid fibril pathway places calcitonin in the extracellular region where amyloid deposits can form. Calcitonin amyloid is found in medullary thyroid carcinoma.
human	CALCA	genes/human/CALCA/CALCA-ai-review.yaml	CALCA	P01258	NCBITaxon:9606	Homo sapiens	28	R-HSA-977136	Amyloid precursor proteins form ordered fibrils	yes	reactome/R-HSA-977136.md	Amyloid precursor proteins form ordered fibrils	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	This annotation from the amyloid fibril formation pathway correctly places calcitonin in the extracellular region where amyloid precursor proteins can aggregate.
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	53	R-HSA-6786205	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1	yes	reactome/R-HSA-6786205.md	KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization for methylation by KAMKMT.
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	95	R-HSA-482772	Release of platelet cytosolic components	yes	reactome/R-HSA-482772.md	Release of platelet cytosolic components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular release from platelets.
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	96	R-HSA-111915	CAMK4 autophosphorylates	yes	reactome/R-HSA-111915.md	CAMK4 autophosphorylates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization for CAMK4 regulation.
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	97	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	98	R-HSA-442749	CaMKK autophosphorylates in the nucleus	yes	reactome/R-HSA-442749.md	CaMKK autophosphorylates in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	99	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	100	R-NUL-9618916	Camkk1 binds activated calmodulin in the nucleus	yes	reactome/R-NUL-9618916.md	Camkk1 binds activated calmodulin in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	101	R-NUL-9619177	Camkk2 phosphorylates CAMK4	yes	reactome/R-NUL-9619177.md	Camkk2 phosphorylates CAMK4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	102	R-HSA-202110	eNOS:Caveolin-1 complex binds to CaM	yes	reactome/R-HSA-202110.md	eNOS:Caveolin-1 complex binds to CaM	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	103	R-HSA-202111	AKT1 phosphorylates eNOS	yes	reactome/R-HSA-202111.md	AKT1 phosphorylates eNOS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	104	R-HSA-202129	HSP90 binds eNOS:Caveolin-1:CaM complex	yes	reactome/R-HSA-202129.md	HSP90 binds eNOS:Caveolin-1:CaM complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	105	R-HSA-202137	AKT1 binds eNOS complex via HSP90	yes	reactome/R-HSA-202137.md	AKT1 binds eNOS complex via HSP90	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	106	R-HSA-202144	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex	yes	reactome/R-HSA-202144.md	Caveolin-1 dissociates from eNOS:CaM:HSP90 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	107	R-HSA-5626549	IQGAPs bind CALM1	yes	reactome/R-HSA-5626549.md	IQGAPs bind CALM1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for CALM1 in plasma membrane.
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	108	R-HSA-111966	GRK2 binds CALM1:4Ca2+	yes	reactome/R-HSA-111966.md	GRK2 binds CALM1:4Ca2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	109	R-HSA-1497784	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle	yes	reactome/R-HSA-1497784.md	The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	110	R-HSA-1497796	BH2 binding can lead to eNOS uncoupling	yes	reactome/R-HSA-1497796.md	BH2 binding can lead to eNOS uncoupling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	111	R-HSA-1497810	Uncoupled eNOS favours the formation of superoxide	yes	reactome/R-HSA-1497810.md	Uncoupled eNOS favours the formation of superoxide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	112	R-HSA-1855153	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol	yes	reactome/R-HSA-1855153.md	I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	113	R-HSA-202110	eNOS:Caveolin-1 complex binds to CaM	yes	reactome/R-HSA-202110.md	eNOS:Caveolin-1 complex binds to CaM	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	114	R-HSA-202111	AKT1 phosphorylates eNOS	yes	reactome/R-HSA-202111.md	AKT1 phosphorylates eNOS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	115	R-HSA-202127	eNOS synthesizes NO	yes	reactome/R-HSA-202127.md	eNOS synthesizes NO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	116	R-HSA-202129	HSP90 binds eNOS:Caveolin-1:CaM complex	yes	reactome/R-HSA-202129.md	HSP90 binds eNOS:Caveolin-1:CaM complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	117	R-HSA-2025890	Calcineurin binds NFATC1,2,3	yes	reactome/R-HSA-2025890.md	Calcineurin binds NFATC1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	118	R-HSA-2730849	Calcineurin binds and dephosphorylates NFAT	yes	reactome/R-HSA-2730849.md	Calcineurin binds and dephosphorylates NFAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	119	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	120	R-HSA-2730872	Activation of Calcineurin	yes	reactome/R-HSA-2730872.md	Activation of Calcineurin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	121	R-HSA-3229181	CALM1:Ca2+ binds CNG channel	yes	reactome/R-HSA-3229181.md	CALM1:Ca2+ binds CNG channel	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	122	R-HSA-4332358	Dissociation of CaM and CAMK2 autophosphorylation	yes	reactome/R-HSA-4332358.md	Dissociation of CaM and CAMK2 autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	123	R-HSA-4332359	Active calmodulin binds CAMK2	yes	reactome/R-HSA-4332359.md	Active calmodulin binds CAMK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	124	R-HSA-4332363	Autophosphorylation and activation of CAMK2	yes	reactome/R-HSA-4332363.md	Autophosphorylation and activation of CAMK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	125	R-HSA-445797	MYLK (MLCK) Active Calmodulin Binding	yes	reactome/R-HSA-445797.md	MYLK (MLCK) Active Calmodulin Binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	126	R-HSA-445813	Phosphorylation of Smooth Muscle Myosin Light Chains	yes	reactome/R-HSA-445813.md	Phosphorylation of Smooth Muscle Myosin Light Chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	127	R-HSA-451283	kainate receptor binds glutamate	yes	reactome/R-HSA-451283.md	kainate receptor binds glutamate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	128	R-HSA-451311	Activation of Ca-permeable Kainate receptors	yes	reactome/R-HSA-451311.md	Activation of Ca-permeable Kainate receptors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	129	R-HSA-4551451	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	yes	reactome/R-HSA-4551451.md	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	130	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	131	R-HSA-482772	Release of platelet cytosolic components	yes	reactome/R-HSA-482772.md	Release of platelet cytosolic components	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	132	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	133	R-HSA-71541	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	yes	reactome/R-HSA-71541.md	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	134	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	135	R-HSA-9618785	Calmodulin binds neurogranin	yes	reactome/R-HSA-9618785.md	Calmodulin binds neurogranin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	136	R-HSA-9619355	CaMKK autophosphorylates in the cytosol	yes	reactome/R-HSA-9619355.md	CaMKK autophosphorylates in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	137	R-HSA-9619376	CAMK1 binds calmodulin	yes	reactome/R-HSA-9619376.md	CAMK1 binds calmodulin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	138	R-HSA-9653585	S-Farn-Me KRAS4B binds calmodulin	yes	reactome/R-HSA-9653585.md	S-Farn-Me KRAS4B binds calmodulin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	139	R-HSA-9654521	Calmodulin dissociates KRAS4B from the plasma membrane	yes	reactome/R-HSA-9654521.md	Calmodulin dissociates KRAS4B from the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	140	R-HSA-9654523	ARL2:GTP bind PDE6D on KRAS4B	yes	reactome/R-HSA-9654523.md	ARL2:GTP bind PDE6D on KRAS4B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	141	R-HSA-9654525	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+	yes	reactome/R-HSA-9654525.md	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	142	R-HSA-9654533	KRAS4B recycles to the plasma membrane	yes	reactome/R-HSA-9654533.md	KRAS4B recycles to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	143	R-HSA-9865670	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)	yes	reactome/R-HSA-9865670.md	TRPV4 tetramer binds CALM1:Ca2+ (calmodulin:Ca2+)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	144	R-NUL-9617449	Rasgrf1 promotes activation of HRAS	yes	reactome/R-NUL-9617449.md	Rasgrf1 promotes activation of HRAS	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	145	R-NUL-9619243	Camkk1 binds activated calmodulin in the cytosol	yes	reactome/R-NUL-9619243.md	Camkk1 binds activated calmodulin in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	146	R-NUL-9619396	CAMKK1 phosphorylates CAMK1	yes	reactome/R-NUL-9619396.md	CAMKK1 phosphorylates CAMK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM1	genes/human/CALM1/CALM1-ai-review.yaml	CALM1	P0DP23	NCBITaxon:9606	Homo sapiens	147	R-NUL-9619413	CAMKK2 phosphorylates Camk1	yes	reactome/R-NUL-9619413.md	CAMKK2 phosphorylates Camk1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation - see individual pathways for specific functions
human	CALM3	genes/human/CALM3/CALM3-ai-review.yaml	CALM3	P0DP25	NCBITaxon:9606	Homo sapiens	58	R-HSA-9956602	CALM binds bacterial OspC3	yes	reactome/R-HSA-9956602.md	CALM binds bacterial OspC3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
human	CALM3	genes/human/CALM3/CALM3-ai-review.yaml	CALM3	P0DP25	NCBITaxon:9606	Homo sapiens	59	R-HSA-9956624	OspC3 ADP-riboxanates CASP4	yes	reactome/R-HSA-9956624.md	OspC3 ADP-riboxanates CASP4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
human	CALM3	genes/human/CALM3/CALM3-ai-review.yaml	CALM3	P0DP25	NCBITaxon:9606	Homo sapiens	60	R-HSA-9956667	CASP4 binds CALM:OspC3	yes	reactome/R-HSA-9956667.md	CASP4 binds CALM:OspC3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	81	R-HSA-8863914	Transport of SEC22B, TAP and PLC from ER to ERGIC	yes	reactome/R-HSA-8863914.md	Transport of SEC22B, TAP and PLC from ER to ERGIC	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	As a soluble ER-luminal protein, calreticulin functions on the luminal side of the ER membrane.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	82	R-HSA-8951499	Loading of antigenic peptides on to class I MHC	yes	reactome/R-HSA-8951499.md	Loading of antigenic peptides on to class I MHC	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Luminal-side ER membrane localization (MHC I peptide loading pathway) is accurate.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	83	R-HSA-983142	Formation of peptide loading complex (PLC)	yes	reactome/R-HSA-983142.md	Formation of peptide loading complex (PLC)	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Luminal-side ER membrane localization (PLC formation) is accurate.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	84	R-HSA-983161	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex	yes	reactome/R-HSA-983161.md	Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Luminal-side ER membrane localization (PLC dissociation) is accurate.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	105	R-HSA-8863858	SEC22B, CALR, STX4, TAP and TAPBP bind	yes	reactome/R-HSA-8863858.md	SEC22B, CALR, STX4, TAP and TAPBP bind	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ERGIC membrane localization reflects trafficking of calreticulin-containing complexes; a minor non-core localization.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	106	R-HSA-8863914	Transport of SEC22B, TAP and PLC from ER to ERGIC	yes	reactome/R-HSA-8863914.md	Transport of SEC22B, TAP and PLC from ER to ERGIC	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ERGIC membrane localization (cross-presentation pathway); minor non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	107	R-HSA-8951595	CALR, TAP, TAPBP dissociate from SEC22B:STX4	yes	reactome/R-HSA-8951595.md	CALR, TAP, TAPBP dissociate from SEC22B:STX4	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ERGIC membrane localization (cross-presentation pathway); minor non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	119	R-HSA-2247514	SCARF1:ligand is endocytosed	yes	reactome/R-HSA-2247514.md	SCARF1:ligand is endocytosed	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular calreticulin in scavenger-receptor (SCARF1) clearance pathway; non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	120	R-HSA-2507854	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	yes	reactome/R-HSA-2507854.md	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular calreticulin in scavenger-receptor (MSR1) clearance pathway; non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	121	R-HSA-8951595	CALR, TAP, TAPBP dissociate from SEC22B:STX4	yes	reactome/R-HSA-8951595.md	CALR, TAP, TAPBP dissociate from SEC22B:STX4	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Phagocytic vesicle membrane localization in cross-presentation; non-core specialized localization.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	122	R-HSA-2247514	SCARF1:ligand is endocytosed	yes	reactome/R-HSA-2247514.md	SCARF1:ligand is endocytosed	Homo sapiens	GO:0071682	endocytic vesicle lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endocytic vesicle lumen localization in scavenger-receptor clearance; non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	123	R-HSA-2507854	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	yes	reactome/R-HSA-2507854.md	MSR1:ligand (SCARA1:ligand, SR-A:ligand) is endocytosed	Homo sapiens	GO:0071682	endocytic vesicle lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endocytic vesicle lumen localization in scavenger-receptor clearance; non-core.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	124	R-HSA-1791082	Expression of Calreticulin	yes	reactome/R-HSA-1791082.md	Expression of Calreticulin	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (calreticulin expression); accurate core compartment.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	125	R-HSA-535717	Binding of calnexin/calreticulin to the unfolded protein	yes	reactome/R-HSA-535717.md	Binding of calnexin/calreticulin to the unfolded protein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for the chaperone-client binding step; accurate.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	126	R-HSA-548890	Removal of the third glucose by glucosidase II and release from the chaperone	yes	reactome/R-HSA-548890.md	Removal of the third glucose by glucosidase II and release from the chaperone	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for the glucosidase II/release step; accurate.
human	CALR	genes/human/CALR/CALR-ai-review.yaml	CALR	P27797	NCBITaxon:9606	Homo sapiens	127	R-HSA-901047	Binding of ERp57	yes	reactome/R-HSA-901047.md	Binding of ERp57	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for ERp57 binding; accurate and functionally central.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	80	R-HSA-432164	Ca2+ influx into the post-synaptic cell	yes	reactome/R-HSA-432164.md	Ca2+ influx into the post-synaptic cell	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for cytosolic localization. CAMK2A is found in the cytosol under basal conditions.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	81	R-HSA-4332356	CAMK2 binds MAP3K7	yes	reactome/R-HSA-4332356.md	CAMK2 binds MAP3K7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization from CaMKII pathway.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	82	R-HSA-4332358	Dissociation of CaM and CAMK2 autophosphorylation	yes	reactome/R-HSA-4332358.md	Dissociation of CaM and CAMK2 autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization from CaMKII pathway.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	83	R-HSA-4332359	Active calmodulin binds CAMK2	yes	reactome/R-HSA-4332359.md	Active calmodulin binds CAMK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization from CaMKII pathway.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	84	R-HSA-4332363	Autophosphorylation and activation of CAMK2	yes	reactome/R-HSA-4332363.md	Autophosphorylation and activation of CAMK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization from CaMKII pathway.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	85	R-HSA-4332388	Activation of MAP3K7 in response to WNT	yes	reactome/R-HSA-4332388.md	Activation of MAP3K7 in response to WNT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization from CaMKII pathway.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	86	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	87	R-HSA-5082387	Phosphorylation of HSF1 at Ser230 induces transactivation	yes	reactome/R-HSA-5082387.md	Phosphorylation of HSF1 at Ser230 induces transactivation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for nucleoplasm localization. CAMK2A can translocate to nucleus to phosphorylate transcription factors.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	88	R-HSA-909552	Phosphorylation of STAT1 at Ser727	yes	reactome/R-HSA-909552.md	Phosphorylation of STAT1 at Ser727	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosol localization.
human	CAMK2A	genes/human/CAMK2A/CAMK2A-ai-review.yaml	CAMK2A	Q9UQM7	NCBITaxon:9606	Homo sapiens	89	R-HSA-416320	Trafficking of GluR1-containing AMPA receptors	yes	reactome/R-HSA-416320.md	Trafficking of GluR1-containing AMPA receptors	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for endocytic vesicle membrane localization. Related to receptor internalization pathways.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	27	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (CAND1 binds nuclear CRL4) is consistent with CAND1 nuclear function.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	28	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization linked to displacement of CAND1 from nuclear CRL4; consistent with CAND1 nuclear function.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular localization derives from a generic granule-exocytosis Reactome pathway and is not a functional site for this intracellular CRL-assembly factor.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	30	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular localization from a generic granule-exocytosis Reactome pathway; not a functional site for CAND1.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	31	R-HSA-5691131	CANDI binds CUL1	yes	reactome/R-HSA-5691131.md	CANDI binds CUL1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization where CAND1 binds CUL1; a core compartment.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	32	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization where CAND1 binds cytosolic CRL E3 ligases; core compartment.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	33	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization linked to displacement of CAND1 from cytosolic CRLs; core compartment.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	34	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Secretory granule lumen derives from a bulk granule-exocytosis Reactome pathway and is not a functional location for this cytosolic/nuclear CRL regulator.
human	CAND1	genes/human/CAND1/CAND1-ai-review.yaml	CAND1	Q86VP6	NCBITaxon:9606	Homo sapiens	35	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Ficolin-1-rich granule lumen derives from a bulk granule-exocytosis Reactome pathway; not a functional location for CAND1.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	36	R-HSA-9683772	Trimmed spike protein binds to calnexin	yes	reactome/R-HSA-9683772.md	Trimmed spike protein binds to calnexin	Homo sapiens	GO:0044183	protein folding chaperone	TAS	enables	MF	false		ACCEPT	Protein folding chaperone is an accurate core molecular function for calnexin.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	42	R-HSA-9683686	Maturation of spike protein	yes	reactome/R-HSA-9683686.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Viral protein processing (e.g. SARS-CoV-2 spike maturation) is a client-specific application of the calnexin chaperone cycle, not a distinct core function.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	43	R-HSA-9932913	Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1	yes	reactome/R-HSA-9932913.md	Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane localization is consistent with the core compartment.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	44	R-HSA-9932988	CANX binds Glu1Man9GlcNAc2-CDH1	yes	reactome/R-HSA-9932988.md	CANX binds Glu1Man9GlcNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane localization (CDH1 processing pathway) is consistent with the core compartment.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	45	R-HSA-983145	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin	yes	reactome/R-HSA-983145.md	Binding of newly synthesized MHC class I heavy chain (HC) with calnexin	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The lectin/chaperone domain of calnexin faces the ER lumen, so luminal-side ER membrane localization is accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	46	R-HSA-983146	Interaction of beta-2-microglobulin (B2M) chain with class I HC	yes	reactome/R-HSA-983146.md	Interaction of beta-2-microglobulin (B2M) chain with class I HC	Homo sapiens	GO:0098553	lumenal side of endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Luminal-side ER membrane localization (MHC I assembly pathway) matches calnexin topology.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	69	R-HSA-2130478	Interaction of invariant chain trimer and MHC II alpha beta dimer	yes	reactome/R-HSA-2130478.md	Interaction of invariant chain trimer and MHC II alpha beta dimer	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	The functional lectin/chaperone domains of calnexin reside in the ER lumen.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	70	R-HSA-2213241	Formation of nonameric complex	yes	reactome/R-HSA-2213241.md	Formation of nonameric complex	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization of the functional domain; accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	71	R-HSA-535717	Binding of calnexin/calreticulin to the unfolded protein	yes	reactome/R-HSA-535717.md	Binding of calnexin/calreticulin to the unfolded protein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for the chaperone-client binding step; accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	72	R-HSA-548890	Removal of the third glucose by glucosidase II and release from the chaperone	yes	reactome/R-HSA-548890.md	Removal of the third glucose by glucosidase II and release from the chaperone	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for the glucosidase II/release step; accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	73	R-HSA-8950342	EBI3:CANX binds IL27	yes	reactome/R-HSA-8950342.md	EBI3:CANX binds IL27	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (EBI3/IL27 assembly pathway); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	74	R-HSA-8950362	EBI3:CANX binds IL12A	yes	reactome/R-HSA-8950362.md	EBI3:CANX binds IL12A	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (EBI3/IL12A assembly pathway); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	75	R-HSA-8950387	CANX binds EBI3	yes	reactome/R-HSA-8950387.md	CANX binds EBI3	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (CANX binds EBI3); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	76	R-HSA-8950398	CANX dissociates from IL27:EBI3	yes	reactome/R-HSA-8950398.md	CANX dissociates from IL27:EBI3	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (CANX dissociates from IL27:EBI3); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	77	R-HSA-8950740	CANX dissociates from IL12A:EBI3	yes	reactome/R-HSA-8950740.md	CANX dissociates from IL12A:EBI3	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (CANX dissociates from IL12A:EBI3); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	78	R-HSA-8951500	Dissociation of CANX from nonameric complex	yes	reactome/R-HSA-8951500.md	Dissociation of CANX from nonameric complex	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (dissociation from nonameric complex); accurate.
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	79	R-HSA-901047	Binding of ERp57	yes	reactome/R-HSA-901047.md	Binding of ERp57	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization for ERp57 binding; accurate and functionally central (P domain recruits ERp57).
human	CANX	genes/human/CANX/CANX-ai-review.yaml	CANX	P27824	NCBITaxon:9606	Homo sapiens	80	R-HSA-9683772	Trimmed spike protein binds to calnexin	yes	reactome/R-HSA-9683772.md	Trimmed spike protein binds to calnexin	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (trimmed spike binds calnexin); accurate.
human	CASP14	genes/human/CASP14/CASP14-ai-review.yaml	CASP14	P31944	NCBITaxon:9606	Homo sapiens	18	R-HSA-6814387	CASP14 cleaves filaggrin	yes	reactome/R-HSA-6814387.md	CASP14 cleaves filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosol localization confirmed by Reactome pathway ""CASP14 cleaves filaggrin"", consistent with other evidence."
human	CASP14	genes/human/CASP14/CASP14-ai-review.yaml	CASP14	P31944	NCBITaxon:9606	Homo sapiens	19	R-HSA-8934819	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin	yes	reactome/R-HSA-8934819.md	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosol localization confirmed by Reactome pathway ""Cytoplasmic proteases cleave Profilaggrin producing Filaggrin""."
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	145	R-HSA-211186	Cleavage of DFF45 (224) by caspase-3	yes	reactome/R-HSA-211186.md	Cleavage of DFF45 (224) by caspase-3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places caspase-3 in the nucleoplasm for nuclear substrate cleavage (e.g., DFF45/ICAD), consistent with active caspase-3 translocating to the nucleus during apoptosis.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	146	R-HSA-211190	Caspase 3-mediated cleavage of DFF45 (117)	yes	reactome/R-HSA-211190.md	Caspase 3-mediated cleavage of DFF45 (117)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places caspase-3 in the nucleoplasm for nuclear substrate cleavage (e.g., DFF45/ICAD), consistent with active caspase-3 translocating to the nucleus during apoptosis.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	147	R-HSA-211219	Translocation of caspase-3 to the nucleus	yes	reactome/R-HSA-211219.md	Translocation of caspase-3 to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places caspase-3 in the nucleoplasm for nuclear substrate cleavage (e.g., DFF45/ICAD), consistent with active caspase-3 translocating to the nucleus during apoptosis.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	148	R-HSA-114252	Cleavage of Procaspase-3 by the apoptosome	yes	reactome/R-HSA-114252.md	Cleavage of Procaspase-3 by the apoptosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	149	R-HSA-201595	Caspase-mediated cleavage of plakophilin-1	yes	reactome/R-HSA-201595.md	Caspase-mediated cleavage of plakophilin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	150	R-HSA-201603	Caspase-mediated cleavage of PKC theta	yes	reactome/R-HSA-201603.md	Caspase-mediated cleavage of PKC theta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	151	R-HSA-201608	Caspase-mediated cleavage of alpha adducin	yes	reactome/R-HSA-201608.md	Caspase-mediated cleavage of alpha adducin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	152	R-HSA-201611	Caspase-mediated cleavage of Rock-1	yes	reactome/R-HSA-201611.md	Caspase-mediated cleavage of Rock-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	153	R-HSA-201622	Caspase-mediated cleavage of gelsolin	yes	reactome/R-HSA-201622.md	Caspase-mediated cleavage of gelsolin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	154	R-HSA-201628	Caspase-mediated cleavage of vimentin at DSVD (85)	yes	reactome/R-HSA-201628.md	Caspase-mediated cleavage of vimentin at DSVD (85)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	155	R-HSA-201629	Caspase-mediated cleavage of Tau	yes	reactome/R-HSA-201629.md	Caspase-mediated cleavage of Tau	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	156	R-HSA-201630	Caspase-mediated cleavage of Acinus	yes	reactome/R-HSA-201630.md	Caspase-mediated cleavage of Acinus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	157	R-HSA-201631	Caspase-mediated cleavage of Desmoglein 3	yes	reactome/R-HSA-201631.md	Caspase-mediated cleavage of Desmoglein 3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	158	R-HSA-201636	Caspase-mediated cleavage of Desmoplakin	yes	reactome/R-HSA-201636.md	Caspase-mediated cleavage of Desmoplakin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	159	R-HSA-201639	Caspase-mediated cleavage of GAS2	yes	reactome/R-HSA-201639.md	Caspase-mediated cleavage of GAS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	160	R-HSA-201640	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha	yes	reactome/R-HSA-201640.md	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	161	R-HSA-2028692	Cleavage of p-STK4 (p-MST1) by caspase 3	yes	reactome/R-HSA-2028692.md	Cleavage of p-STK4 (p-MST1) by caspase 3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	162	R-HSA-2028697	Cleavage of p-STK3 (p-MST2) by caspase 3	yes	reactome/R-HSA-2028697.md	Cleavage of p-STK3 (p-MST2) by caspase 3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	163	R-HSA-202917	Caspase-mediated cleavage of Desmoglein 1	yes	reactome/R-HSA-202917.md	Caspase-mediated cleavage of Desmoglein 1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	164	R-HSA-202939	Caspase-mediated cleavage of E-Cadherin	yes	reactome/R-HSA-202939.md	Caspase-mediated cleavage of E-Cadherin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	165	R-HSA-202947	Caspase mediated cleavage of APC	yes	reactome/R-HSA-202947.md	Caspase mediated cleavage of APC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	166	R-HSA-202960	Caspase mediated cleavage of C-IAP1	yes	reactome/R-HSA-202960.md	Caspase mediated cleavage of C-IAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	167	R-HSA-202966	Caspase mediated cleavage of HIP-55	yes	reactome/R-HSA-202966.md	Caspase mediated cleavage of HIP-55	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	168	R-HSA-202967	Caspase mediated cleavage of alpha-II-Fodrin	yes	reactome/R-HSA-202967.md	Caspase mediated cleavage of alpha-II-Fodrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	169	R-HSA-202969	Caspase mediated cleavage of beta-catenin	yes	reactome/R-HSA-202969.md	Caspase mediated cleavage of beta-catenin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	170	R-HSA-205117	p75NTR:NADE promotes caspase2/3 activation	yes	reactome/R-HSA-205117.md	p75NTR:NADE promotes caspase2/3 activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	171	R-HSA-211219	Translocation of caspase-3 to the nucleus	yes	reactome/R-HSA-211219.md	Translocation of caspase-3 to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	172	R-HSA-212552	Caspase 3-mediated cleavage of PKC delta	yes	reactome/R-HSA-212552.md	Caspase 3-mediated cleavage of PKC delta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	173	R-HSA-350651	Caspase-mediated cleavage of MASK	yes	reactome/R-HSA-350651.md	Caspase-mediated cleavage of MASK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	174	R-HSA-351849	Caspase-mediated cleavage of Etk	yes	reactome/R-HSA-351849.md	Caspase-mediated cleavage of Etk	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	175	R-HSA-351871	Caspase-mediated cleavage of Z0-2	yes	reactome/R-HSA-351871.md	Caspase-mediated cleavage of Z0-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	176	R-HSA-351876	Caspase-mediated cleavage of occludin	yes	reactome/R-HSA-351876.md	Caspase-mediated cleavage of occludin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	177	R-HSA-351877	Caspase-mediated cleavage of Desmoglein 2	yes	reactome/R-HSA-351877.md	Caspase-mediated cleavage of Desmoglein 2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	178	R-HSA-351901	Caspase-mediated cleavage of MST3	yes	reactome/R-HSA-351901.md	Caspase-mediated cleavage of MST3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	179	R-HSA-351913	Caspase-mediated cleavage of TJP1	yes	reactome/R-HSA-351913.md	Caspase-mediated cleavage of TJP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	180	R-HSA-373705	Caspase cleavage of DCC	yes	reactome/R-HSA-373705.md	Caspase cleavage of DCC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	181	R-HSA-418845	Activation of caspase-3	yes	reactome/R-HSA-418845.md	Activation of caspase-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	182	R-HSA-449073	Caspase-3 cleaves pro-interleukin-16	yes	reactome/R-HSA-449073.md	Caspase-3 cleaves pro-interleukin-16	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	183	R-HSA-9627104	XIAP binds CASP3	yes	reactome/R-HSA-9627104.md	XIAP binds CASP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	184	R-HSA-9647632	CASP3 cleaves GSDME	yes	reactome/R-HSA-9647632.md	CASP3 cleaves GSDME	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	185	R-HSA-9686088	CASP3 cleaves GSDMD	yes	reactome/R-HSA-9686088.md	CASP3 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP3	genes/human/CASP3/CASP3-ai-review.yaml	CASP3	P42574	NCBITaxon:9606	Homo sapiens	186	R-NUL-211643	Cleavage of PAK-2 at 212	yes	reactome/R-NUL-211643.md	Cleavage of PAK-2 at 212	Oryctolagus cuniculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places caspase-3 (and its substrate-cleavage reactions) in the cytosol, the principal compartment of caspase-3 activity.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	23	R-HSA-9947861	CASP4 autocatalysis on LPS micelles	yes	reactome/R-HSA-9947861.md	CASP4 autocatalysis on LPS micelles	Homo sapiens	GO:0004197	cysteine-type endopeptidase activity	TAS	enables	MF	false		ACCEPT	CASP4 is a cysteine protease that cleaves after Asp; this is its uncontested core molecular function.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	24	R-HSA-9948001	CASP4 inflammasome assembly	yes	reactome/R-HSA-9948001.md	CASP4 inflammasome assembly	Homo sapiens	GO:0160075	non-canonical inflammasome complex assembly	TAS	involved_in	BP	false		ACCEPT	LPS engagement drives CARD-mediated oligomerisation of CASP4 into the non-canonical inflammasome.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	25	R-HSA-9947861	CASP4 autocatalysis on LPS micelles	yes	reactome/R-HSA-9947861.md	CASP4 autocatalysis on LPS micelles	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	26	R-HSA-9947908	CASP4 autocatalysis on the bacterial surface	yes	reactome/R-HSA-9947908.md	CASP4 autocatalysis on the bacterial surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	27	R-HSA-9947987	CASP4 cleaves IL18 at D36	yes	reactome/R-HSA-9947987.md	CASP4 cleaves IL18 at D36	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	28	R-HSA-9948146	CASP4 cleaves GSDMD	yes	reactome/R-HSA-9948146.md	CASP4 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	29	R-HSA-9956624	OspC3 ADP-riboxanates CASP4	yes	reactome/R-HSA-9956624.md	OspC3 ADP-riboxanates CASP4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	30	R-HSA-9958657	CASP4 cleaves IL1B at D27	yes	reactome/R-HSA-9958657.md	CASP4 cleaves IL1B at D27	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	31	R-HSA-9960526	CASP4 cleaves IL1B at D116	yes	reactome/R-HSA-9960526.md	CASP4 cleaves IL1B at D116	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	90	R-HSA-9686096	CASP4 binds LPS micelles	yes	reactome/R-HSA-9686096.md	CASP4 binds LPS micelles	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	91	R-HSA-9686271	CASP4 dimerizes	yes	reactome/R-HSA-9686271.md	CASP4 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	92	R-HSA-9947934	CASP4 binds exposed LPS on the bacterial surface	yes	reactome/R-HSA-9947934.md	CASP4 binds exposed LPS on the bacterial surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	93	R-HSA-9947940	CASP4 forms dimers on the bacterial surface	yes	reactome/R-HSA-9947940.md	CASP4 forms dimers on the bacterial surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	94	R-HSA-9948160	SERPINB1 binds CASP4	yes	reactome/R-HSA-9948160.md	SERPINB1 binds CASP4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	95	R-HSA-9956613	CASP4 binds nleF	yes	reactome/R-HSA-9956613.md	CASP4 binds nleF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP4	genes/human/CASP4/CASP4-ai-review.yaml	CASP4	P49662	NCBITaxon:9606	Homo sapiens	96	R-HSA-9956667	CASP4 binds CALM:OspC3	yes	reactome/R-HSA-9956667.md	CASP4 binds CALM:OspC3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by phylogeny, by UniProt subcellular-location mapping, by Reactome and by direct observation.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	65	R-HSA-114259	Cleavage of Procaspase‑9 to caspase‑9	yes	reactome/R-HSA-114259.md	Cleavage of Procaspase‑9 to caspase‑9	Homo sapiens	GO:0004197	cysteine-type endopeptidase activity	TAS	enables	MF	false		ACCEPT	Reactome pathway annotation for caspase-9 cleavage. CRITICAL: This catalytic activity is ONLY present in isoform 1.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	71	R-HSA-9627089	CASP9 is phosphorylated at T412	yes	reactome/R-HSA-9627089.md	CASP9 is phosphorylated at T412	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for caspase-9 localization in phosphorylation reaction.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	85	R-HSA-114252	Cleavage of Procaspase-3 by the apoptosome	yes	reactome/R-HSA-114252.md	Cleavage of Procaspase-3 by the apoptosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for procaspase-3 cleavage by apoptosome.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	86	R-HSA-114259	Cleavage of Procaspase‑9 to caspase‑9	yes	reactome/R-HSA-114259.md	Cleavage of Procaspase‑9 to caspase‑9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for procaspase-9 cleavage.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	87	R-HSA-114261	Cleavage of Procaspase-7 by the apoptosome	yes	reactome/R-HSA-114261.md	Cleavage of Procaspase-7 by the apoptosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for procaspase-7 cleavage by apoptosome.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	88	R-HSA-373700	Caspase-9 binds DCC:DIP13alpha complex	yes	reactome/R-HSA-373700.md	Caspase-9 binds DCC:DIP13alpha complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for caspase-9 binding to DCC:DIP13alpha complex.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	89	R-HSA-418845	Activation of caspase-3	yes	reactome/R-HSA-418845.md	Activation of caspase-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for caspase-3 activation.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	90	R-HSA-6804596	APAF1:CYCS binds APIP	yes	reactome/R-HSA-6804596.md	APAF1:CYCS binds APIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for APAF1:CYCS binding APIP.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	91	R-HSA-6805426	CARD8 binds CASP9(1-416)	yes	reactome/R-HSA-6805426.md	CARD8 binds CASP9(1-416)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CARD8 binding to CASP9(1-416).
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	92	R-HSA-9627056	Procaspase 9 forms dimer	yes	reactome/R-HSA-9627056.md	Procaspase 9 forms dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for procaspase-9 dimer formation.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	93	R-HSA-9627078	XIAP binds CASP9	yes	reactome/R-HSA-9627078.md	XIAP binds CASP9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for XIAP binding CASP9.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	96	R-HSA-114256	CYCS:APAF1 binds procaspase-9	yes	reactome/R-HSA-114256.md	CYCS:APAF1 binds procaspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CYCS:APAF1 binding procaspase-9.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	97	R-HSA-198621	AKT phosphorylates caspase-9	yes	reactome/R-HSA-198621.md	AKT phosphorylates caspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for AKT phosphorylates caspase-9.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	98	R-HSA-2399985	AKT1 E17K mutant phosphorylates caspase-9	yes	reactome/R-HSA-2399985.md	AKT1 E17K mutant phosphorylates caspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for AKT1 E17K mutant phosphorylates caspase-9.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	99	R-HSA-6804596	APAF1:CYCS binds APIP	yes	reactome/R-HSA-6804596.md	APAF1:CYCS binds APIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate annotation - same as earlier entry.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	100	R-HSA-6805426	CARD8 binds CASP9(1-416)	yes	reactome/R-HSA-6805426.md	CARD8 binds CASP9(1-416)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate annotation - same as earlier entry.
human	CASP9	genes/human/CASP9/CASP9-ai-review.yaml	CASP9	P55211	NCBITaxon:9606	Homo sapiens	101	R-HSA-9627056	Procaspase 9 forms dimer	yes	reactome/R-HSA-9627056.md	Procaspase 9 forms dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate annotation - same as earlier entry.
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	9	R-HSA-9758881	Uptake of dietary cobalamins into enterocytes	yes	reactome/R-HSA-9758881.md	Uptake of dietary cobalamins into enterocytes	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS annotation to cobalamin transport, from the ""Uptake of dietary cobalamins into enterocytes"" pathway. CBLIF binds dietary cobalamin and delivers it to the ileal cubam receptor for absorption; this is the core process."
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	11	R-HSA-3000103	CUBN:AMN binds CBLIF:RCbl	yes	reactome/R-HSA-3000103.md	CUBN:AMN binds CBLIF:RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to extracellular region for the reaction in which the cubam (CUBN:AMN) receptor binds the secreted CBLIF:RCbl complex. Correct for a secreted protein acting on the intestinal luminal/apical surface.
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	12	R-HSA-3000120	CBLIF binds RCbl	yes	reactome/R-HSA-3000120.md	CBLIF binds RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to extracellular region for the reaction ""CBLIF binds RCbl"" (binding of free cobalamin by secreted intrinsic factor in the intestinal lumen). Correct for the secreted protein."
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	13	R-HSA-3000137	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000137.md	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to extracellular region for the cubam-mediated uptake reaction. Correct for the secreted CBLIF:RCbl complex engaging the cell-surface receptor prior to internalization.
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	14	R-HSA-3296462	Defective CUBN does not transport GIF:Cbl	yes	reactome/R-HSA-3296462.md	Defective CUBN does not transport GIF:Cbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to extracellular region for the disease reaction ""Defective CUBN does not transport GIF:Cbl"". The extracellular localization of CBLIF is correct regardless of the disease context."
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	15	R-HSA-3296477	Defective AMN does not transport GIF:Cbl	yes	reactome/R-HSA-3296477.md	Defective AMN does not transport GIF:Cbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to extracellular region for the disease reaction ""Defective AMN does not transport GIF:Cbl"". The secreted CBLIF localization is correct."
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	16	R-HSA-3315455	Defective CBLIF does not bind Cbl	yes	reactome/R-HSA-3315455.md	Defective CBLIF does not bind Cbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to extracellular region for the disease reaction ""Defective CBLIF does not bind Cbl"". The secreted CBLIF localization is correct."
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	17	R-HSA-3000137	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000137.md	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to lysosomal lumen. After cubam-mediated endocytosis in the ileal enterocyte, the CBLIF:RCbl complex is delivered to lysosomes, where cobalamin is released and CBLIF is degraded. This is a genuine trafficking endpoint but not the protein's core (secreted, cobalamin-binding) function.
human	CBLIF	genes/human/CBLIF/CBLIF-ai-review.yaml	CBLIF	P27352	NCBITaxon:9606	Homo sapiens	18	R-HSA-3000243	Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl	yes	reactome/R-HSA-3000243.md	Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to lysosomal lumen for the reaction in which a lysosomal protease degrades CBLIF:RCbl to release cobalamin. Same non-core trafficking endpoint as R-HSA-3000137.
human	CBS	genes/human/CBS/CBS-ai-review.yaml	CBS	P35520	NCBITaxon:9606	Homo sapiens	45	R-HSA-1614524	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine	yes	reactome/R-HSA-1614524.md	PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic CBS tetramers catalyzing cystathionine formation.
human	CC2D2A	genes/human/CC2D2A/CC2D2A-ai-review.yaml	CC2D2A	Q9P2K1	NCBITaxon:9606	Homo sapiens	2	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CC2D2A has a cytoplasmic pool associated with ciliary-base assembly.
human	CC2D2A	genes/human/CC2D2A/CC2D2A-ai-review.yaml	CC2D2A	Q9P2K1	NCBITaxon:9606	Homo sapiens	3	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CC2D2A has a cytoplasmic pool associated with ciliary-base assembly.
human	CC2D2A	genes/human/CC2D2A/CC2D2A-ai-review.yaml	CC2D2A	Q9P2K1	NCBITaxon:9606	Homo sapiens	4	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CC2D2A has a cytoplasmic pool associated with ciliary-base assembly.
human	CCL11	genes/human/CCL11/CCL11-ai-review.yaml	CCL11	P51671	NCBITaxon:9606	Homo sapiens	45	R-HSA-443986	Receptor ACKR2 binds most inflammatory CC chemokines	yes	reactome/R-HSA-443986.md	Receptor ACKR2 binds most inflammatory CC chemokines	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Receptor ACKR2 binds most inflammatory CC chemokines"". CCL11 is a secreted protein that binds to ACKR2 (a decoy chemokine receptor) in the extracellular region. This is consistent with its localization as a secreted chemokine."
human	CCL11	genes/human/CCL11/CCL11-ai-review.yaml	CCL11	P51671	NCBITaxon:9606	Homo sapiens	46	R-HSA-6793978	Expression of STAT6-upregulated extracellular proteins	yes	reactome/R-HSA-6793978.md	Expression of STAT6-upregulated extracellular proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Expression of STAT6-upregulated extracellular proteins"". CCL11 is a STAT6-induced secreted protein, consistent with its regulation by IL-4/IL-13 signaling and extracellular localization."
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	55	R-HSA-170044	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	yes	reactome/R-HSA-170044.md	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	56	R-HSA-170070	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	yes	reactome/R-HSA-170070.md	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	57	R-HSA-170072	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	yes	reactome/R-HSA-170072.md	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	58	R-HSA-170076	CAK phosphorylates CDK1 bound to CCNB1	yes	reactome/R-HSA-170076.md	CAK phosphorylates CDK1 bound to CCNB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	59	R-HSA-170131	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	yes	reactome/R-HSA-170131.md	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	60	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	61	R-HSA-174122	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	yes	reactome/R-HSA-174122.md	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	62	R-HSA-174132	Free APC/C phosphorylated by Cyclin B:Cdc2	yes	reactome/R-HSA-174132.md	Free APC/C phosphorylated by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	63	R-HSA-174251	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	yes	reactome/R-HSA-174251.md	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	64	R-HSA-2245218	CDK1 phosphorylates PHF8	yes	reactome/R-HSA-2245218.md	CDK1 phosphorylates PHF8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	65	R-HSA-2294600	CDK1 phosphorylates condensin II subunit NCAPD3	yes	reactome/R-HSA-2294600.md	CDK1 phosphorylates condensin II subunit NCAPD3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	66	R-HSA-380278	CCNB1:p-T160-CDK1 phosphorylates NUMA1	yes	reactome/R-HSA-380278.md	CCNB1:p-T160-CDK1 phosphorylates NUMA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	67	R-HSA-4088024	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	yes	reactome/R-HSA-4088024.md	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	68	R-HSA-4088298	FOXM1 stimulates CCNB1 transcription	yes	reactome/R-HSA-4088298.md	FOXM1 stimulates CCNB1 transcription	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	69	R-HSA-5195402	CDK1 phosphorylates LPIN	yes	reactome/R-HSA-5195402.md	CDK1 phosphorylates LPIN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	70	R-HSA-5244669	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments	yes	reactome/R-HSA-5244669.md	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	71	R-HSA-9009282	CDK1 phosphorylates RUNX2	yes	reactome/R-HSA-9009282.md	CDK1 phosphorylates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	72	R-HSA-9851092	NPM1-ALK and FOXM1-dependent CCNB1 gene expression	yes	reactome/R-HSA-9851092.md	NPM1-ALK and FOXM1-dependent CCNB1 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	73	R-NUL-2434198	CDK1 phosphorylates Mastl	yes	reactome/R-NUL-2434198.md	CDK1 phosphorylates Mastl	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	87	R-HSA-170044	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	yes	reactome/R-HSA-170044.md	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	88	R-HSA-170055	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170055.md	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	89	R-HSA-170057	Formation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170057.md	Formation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	90	R-HSA-170072	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	yes	reactome/R-HSA-170072.md	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	91	R-HSA-170126	Phosphorylation of Cyclin B1 in the CRS domain	yes	reactome/R-HSA-170126.md	Phosphorylation of Cyclin B1 in the CRS domain	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	92	R-HSA-170131	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	yes	reactome/R-HSA-170131.md	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	93	R-HSA-170161	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	yes	reactome/R-HSA-170161.md	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	94	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	95	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	96	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	97	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	98	R-HSA-2468293	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	yes	reactome/R-HSA-2468293.md	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	99	R-HSA-2984220	CDK1:CCNB phosphorylates NEK9	yes	reactome/R-HSA-2984220.md	CDK1:CCNB phosphorylates NEK9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	100	R-HSA-2990882	CDK1 phosphorylates NUP98	yes	reactome/R-HSA-2990882.md	CDK1 phosphorylates NUP98	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	101	R-HSA-4086410	CCNB:CDK1 phosphorylates BORA	yes	reactome/R-HSA-4086410.md	CCNB:CDK1 phosphorylates BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	102	R-HSA-6803875	SFN dimer binds CDK1 and CCNB1	yes	reactome/R-HSA-6803875.md	SFN dimer binds CDK1 and CCNB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	103	R-HSA-9624800	CDK1 phosphorylates LBR	yes	reactome/R-HSA-9624800.md	CDK1 phosphorylates LBR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	104	R-HSA-9858641	MITF-M-dependent CCNB1 gene expression	yes	reactome/R-HSA-9858641.md	MITF-M-dependent CCNB1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCNB1	genes/human/CCNB1/CCNB1-ai-review.yaml	CCNB1	P14635	NCBITaxon:9606	Homo sapiens	105	R-NUL-2422970	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB	yes	reactome/R-NUL-2422970.md	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome mitotic pathways.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	104	R-HSA-1226094	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	yes	reactome/R-HSA-1226094.md	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	105	R-HSA-1226095	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	yes	reactome/R-HSA-1226095.md	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	106	R-HSA-3215385	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	yes	reactome/R-HSA-3215385.md	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	107	R-HSA-3215426	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77	yes	reactome/R-HSA-3215426.md	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	108	R-HSA-5205799	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)	yes	reactome/R-HSA-5205799.md	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	109	R-HSA-5205861	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)	yes	reactome/R-HSA-5205861.md	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	110	R-HSA-5216234	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)	yes	reactome/R-HSA-5216234.md	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	111	R-HSA-5661117	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3	yes	reactome/R-HSA-5661117.md	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	112	R-HSA-6790036	Expression of STAT3-upregulated nuclear proteins	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	113	R-HSA-69227	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-69227.md	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	114	R-HSA-75822	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	yes	reactome/R-HSA-75822.md	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	115	R-HSA-75823	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm	yes	reactome/R-HSA-75823.md	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	116	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	117	R-HSA-8942836	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	yes	reactome/R-HSA-8942836.md	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	118	R-HSA-8952058	CCND1 binds RUNX3 and displaces EP300	yes	reactome/R-HSA-8952058.md	CCND1 binds RUNX3 and displaces EP300	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	119	R-HSA-8952062	CCND1 recruits HDAC4 to RUNX3	yes	reactome/R-HSA-8952062.md	CCND1 recruits HDAC4 to RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	120	R-HSA-8952069	HDAC4 deacetylates RUNX3	yes	reactome/R-HSA-8952069.md	HDAC4 deacetylates RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	121	R-HSA-9008412	CDK4 phosphorylates RUNX2	yes	reactome/R-HSA-9008412.md	CDK4 phosphorylates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	122	R-HSA-9754129	CDK6 inhibitors bind CDK6	yes	reactome/R-HSA-9754129.md	CDK6 inhibitors bind CDK6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	123	R-HSA-9754130	CDK4 inhibitors bind CDK4	yes	reactome/R-HSA-9754130.md	CDK4 inhibitors bind CDK4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Cyclin D1 acts in the nucleoplasm as part of the cyclin D1-CDK4/6 holoenzyme.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	129	R-HSA-75822	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	yes	reactome/R-HSA-75822.md	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	130	R-HSA-75823	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm	yes	reactome/R-HSA-75823.md	Relocalization of nuclearly localized Cyclin D1 to the cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	131	R-HSA-75824	Ubiquitination of Cyclin D1	yes	reactome/R-HSA-75824.md	Ubiquitination of Cyclin D1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	132	R-HSA-75825	Proteasome mediated degradation of Cyclin D1	yes	reactome/R-HSA-75825.md	Proteasome mediated degradation of Cyclin D1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	133	R-HSA-8848414	Activated PTK6 binds CDKN1B	yes	reactome/R-HSA-8848414.md	Activated PTK6 binds CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	134	R-HSA-8848436	PTK6 phosphorylates CDKN1B	yes	reactome/R-HSA-8848436.md	PTK6 phosphorylates CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	135	R-HSA-8853956	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1	yes	reactome/R-HSA-8853956.md	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1 and inhibited by VENTX:TCF4,LEF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	136	R-HSA-8941895	Formation of CDK4/6:CCND complexes	yes	reactome/R-HSA-8941895.md	Formation of CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	137	R-HSA-8941915	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	yes	reactome/R-HSA-8941915.md	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	138	R-HSA-8942607	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	yes	reactome/R-HSA-8942607.md	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	139	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	140	R-HSA-8951443	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1	yes	reactome/R-HSA-8951443.md	Expression of CCND1 is stimulated by CTNNB1:TCF4,LEF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	141	R-HSA-9009378	Estrogen-responsive CCND1 gene expression	yes	reactome/R-HSA-9009378.md	Estrogen-responsive CCND1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	142	R-HSA-9623355	ESR1-dependent CCND1 expression	yes	reactome/R-HSA-9623355.md	ESR1-dependent CCND1 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	143	R-HSA-9858645	MITF-M and CTNNB1-dependent CCND1 expression	yes	reactome/R-HSA-9858645.md	MITF-M and CTNNB1-dependent CCND1 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCND1	genes/human/CCND1/CCND1-ai-review.yaml	CCND1	P24385	NCBITaxon:9606	Homo sapiens	144	R-HSA-9929482	CDK4:CCND1 phosphorylates SPOP	yes	reactome/R-HSA-9929482.md	CDK4:CCND1 phosphorylates SPOP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-derived cytosolic localisation, reflecting cyclin D1 export, ubiquitination and proteasomal degradation and cytoplasmic holoenzyme assembly.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	53	R-HSA-187520	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	yes	reactome/R-HSA-187520.md	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasmic localization, from the Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 reaction.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	54	R-HSA-187552	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from binding of phospho-p27/p21 to SCF(Skp2):Cks1 complex.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	55	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from degradation of ubiquitinated p27/p21 by 26S proteasome.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	56	R-HSA-187575	Ubiquitination of phospho-p27/p21	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from ubiquitination of phospho-p27/p21.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	57	R-HSA-188350	CAK-mediated phosphorylation of Cyclin E:Cdk2	yes	reactome/R-HSA-188350.md	CAK-mediated phosphorylation of Cyclin E:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from CAK-mediated phosphorylation of Cyclin E:Cdk2.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	58	R-HSA-188386	Association of Rb with Cyclin E:Cdk2 complexes	yes	reactome/R-HSA-188386.md	Association of Rb with Cyclin E:Cdk2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from association of Rb with Cyclin E:Cdk2 complexes.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	59	R-HSA-188390	Cyclin E:CDK2-mediated phosphorylation of RB1	yes	reactome/R-HSA-188390.md	Cyclin E:CDK2-mediated phosphorylation of RB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from Cyclin E:CDK2-mediated phosphorylation of RB1.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	60	R-HSA-69005	Cdc6 protein is phosphorylated by CDK	yes	reactome/R-HSA-69005.md	Cdc6 protein is phosphorylated by CDK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from Cdc6 phosphorylation by CDK.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	61	R-HSA-69195	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	yes	reactome/R-HSA-69195.md	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from phosphorylation of Cyclin E:CDK2 complexes by WEE1.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	62	R-HSA-69199	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A	yes	reactome/R-HSA-69199.md	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm, from dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	63	R-HSA-157906	Translocation of Cyclin E:Cdk2 complex to the nucleus	yes	reactome/R-HSA-157906.md	Translocation of Cyclin E:Cdk2 complex to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol, from translocation of Cyclin E:Cdk2 complex to the nucleus. Cyclin E-CDK2 is present in the cytosol before nuclear translocation.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	64	R-HSA-69191	Formation of Cyclin E:Cdk2 complexes	yes	reactome/R-HSA-69191.md	Formation of Cyclin E:Cdk2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol, from formation of Cyclin E:Cdk2 complexes.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	65	R-HSA-8961846	CCNE1 gene transcription is stimulated by E2F1	yes	reactome/R-HSA-8961846.md	CCNE1 gene transcription is stimulated by E2F1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol, from CCNE1 gene transcription stimulated by E2F1. This annotation seems to be about the gene product being present in cytosol in the context of its transcriptional regulation.
human	CCNE1	genes/human/CCNE1/CCNE1-ai-review.yaml	CCNE1	P24864	NCBITaxon:9606	Homo sapiens	66	R-HSA-9706390	RHOBTB3 binds interacting proteins at trans-Golgi network	yes	reactome/R-HSA-9706390.md	RHOBTB3 binds interacting proteins at trans-Golgi network	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol from RHOBTB3 interaction at trans-Golgi network. This is a less well-characterized interaction.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	66	R-HSA-202165	Phosphorylation of ITAM motifs in CD3 complexes	yes	reactome/R-HSA-202165.md	Phosphorylation of ITAM motifs in CD3 complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane from Reactome ITAM phosphorylation pathway.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	67	R-HSA-202168	TCR signaling - ZAP70 activation	yes	reactome/R-HSA-202168.md	Phosphorylation of ZAP-70 by Lck	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	68	R-HSA-202174	TCR signaling pathway	yes	reactome/R-HSA-202174.md	Activation of ZAP-70	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	69	R-HSA-202216	TCR signaling - LAT phosphorylation	yes	reactome/R-HSA-202216.md	Phosphorylation of SLP-76	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	70	R-HSA-202245	TCR signaling cascade	yes	reactome/R-HSA-202245.md	Phosphorylation of TBSMs in LAT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	71	R-HSA-202248	TCR signal transduction	yes	reactome/R-HSA-202248.md	Phosphorylation of PLC-gamma1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	72	R-HSA-202344	TCR signaling events	yes	reactome/R-HSA-202344.md	Recruitment of ZAP-70 to phosphorylated ITAMs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	73	R-HSA-2029268	TCR signaling - downstream events	yes	reactome/R-HSA-2029268.md	Phosphorylation and activation of PLCG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR downstream events.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	74	R-HSA-2029270	CD28 dependent signaling	yes	reactome/R-HSA-2029270.md	Recruitment of PLCgamma to membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CD28 costimulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	75	R-HSA-2029271	Costimulation by CD28	yes	reactome/R-HSA-2029271.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CD28 costimulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	76	R-HSA-2029272	CD28 costimulation	yes	reactome/R-HSA-2029272.md	Release of PLCG from FCGR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CD28 costimulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	77	R-HSA-2029273	CD28 signaling pathway	yes	reactome/R-HSA-2029273.md	PI3K binds to p-6Y-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CD28 costimulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	78	R-HSA-2029451	PD-1 signaling	yes	reactome/R-HSA-2029451.md	Activation of RAC1 by VAV	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome PD-1 signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	79	R-HSA-2029452	PD-1 pathway	yes	reactome/R-HSA-2029452.md	Recruitment of SYK to phosphorylated ITAMs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome PD-1 signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	80	R-HSA-2029453	CTLA-4 inhibitory signaling	yes	reactome/R-HSA-2029453.md	Phosphorylation of VAV	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CTLA-4 signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	81	R-HSA-2029457	Immunoregulatory signaling	yes	reactome/R-HSA-2029457.md	Cross-linking of FCGRIIIA with IgG-coated Ag	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome immunoregulatory signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	82	R-HSA-2029458	Checkpoint signaling	yes	reactome/R-HSA-2029458.md	Recruitment of VAV1 to p-6Y-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome checkpoint signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	83	R-HSA-2029459	TCR checkpoint	yes	reactome/R-HSA-2029459.md	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR checkpoint.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	84	R-HSA-2029467	TCR regulation	yes	reactome/R-HSA-2029467.md	Activation of RAC1 by CRKII:DOCK180:ELMO	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR regulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	85	R-HSA-2029476	TCR complex regulation	yes	reactome/R-HSA-2029476.md	Role of myosins in phagosome formation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR complex regulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	86	R-HSA-2197697	TCR signaling in adaptive immunity	yes	reactome/R-HSA-2197697.md	Recruitment of CRKII:DOCK180:ELMO complex to FCGR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome adaptive immunity.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	87	R-HSA-389758	TCR signaling	yes	reactome/R-HSA-389758.md	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	88	R-HSA-8855381	TCR signaling events	yes	reactome/R-HSA-8855381.md	PTPN22 dephosphorylates ZAP70	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	89	R-HSA-9664261	PD-L1 expression	yes	reactome/R-HSA-9664261.md	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome PD-L1 pathway.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	90	R-HSA-9664270	Immune checkpoint signaling	yes	reactome/R-HSA-9664270.md	Recruitment of PLCgamma to membrane due to FCGR3A effect	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome checkpoint signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	91	R-HSA-9664271	Checkpoint inhibition	yes	reactome/R-HSA-9664271.md	Release of PLCG from FCGR3A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome checkpoint inhibition.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	92	R-HSA-9664273	Immunomodulation	yes	reactome/R-HSA-9664273.md	SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome immunomodulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	93	R-HSA-9664275	Immune regulation	yes	reactome/R-HSA-9664275.md	Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome immune regulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	94	R-HSA-9664278	T cell regulation	yes	reactome/R-HSA-9664278.md	Phosphorylation and activation of PLCG due to FCGR3A effect	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome T cell regulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	95	R-HSA-9666425	CAR-T cell signaling	yes	reactome/R-HSA-9666425.md	p-6Y-SYK phosphorylates VAV1,2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CAR-T signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	96	R-HSA-9666426	CAR signaling	yes	reactome/R-HSA-9666426.md	CRKII:DOCK180:ELMO binds FCGR3A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CAR signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	97	R-HSA-9666428	Chimeric receptor signaling	yes	reactome/R-HSA-9666428.md	DOCK180 exchanges GTP for GDP on RAC1:GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome chimeric receptor signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	98	R-HSA-9666430	CAR-T pathway	yes	reactome/R-HSA-9666430.md	p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CAR-T pathway.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	99	R-HSA-9666435	CAR activation	yes	reactome/R-HSA-9666435.md	VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CAR activation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	100	R-HSA-9666458	CAR-T cell activation	yes	reactome/R-HSA-9666458.md	IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome CAR-T cell activation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	101	R-HSA-164943	TCR receptor complex	yes	reactome/R-HSA-164943.md	Nef mediated activation of the T-cell receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR receptor complex.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	102	R-HSA-198955	TCR formation	yes	reactome/R-HSA-198955.md	TCR complex interacts with peptide antigen-presenting MHC Class I	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR formation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	103	R-HSA-202214	TCR assembly	yes	reactome/R-HSA-202214.md	Dephosphorylation of Lck-pY505 by CD45	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR assembly.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	104	R-HSA-202233	TCR complex assembly	yes	reactome/R-HSA-202233.md	Inactivation of Lck by Csk	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR complex assembly.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	105	R-HSA-202291	TCR complex formation	yes	reactome/R-HSA-202291.md	Activation of Lck	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR complex formation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	106	R-HSA-202307	TCR signaling initiation	yes	reactome/R-HSA-202307.md	Change of PKC theta conformation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling initiation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	107	R-HSA-5685600	TCR phosphorylation	yes	reactome/R-HSA-5685600.md	viral HA binds NCRI	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR phosphorylation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	108	R-HSA-5685602	ITAM phosphorylation	yes	reactome/R-HSA-5685602.md	NCR3LG1 binds NCR3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome ITAM phosphorylation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	109	R-HSA-6793275	TCR-CD3 complex	yes	reactome/R-HSA-6793275.md	CMVPP65 binds NCR3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR-CD3 complex.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	110	R-HSA-8850326	TCR signaling cascade	yes	reactome/R-HSA-8850326.md	TCR binds self-lipid-based antigen via CD1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling cascade.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	111	R-HSA-8850356	T cell signaling	yes	reactome/R-HSA-8850356.md	TCR binds microbial lipid-based antigen via CD1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome T cell signaling.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	112	R-HSA-8852200	T cell activation	yes	reactome/R-HSA-8852200.md	Inactivation of LCK by PTPN22	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome T cell activation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	113	R-HSA-9664268	TCR signaling modulation	yes	reactome/R-HSA-9664268.md	Opsonized leishmania amastigote binds FCGR3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome TCR signaling modulation.
human	CD247	genes/human/CD247/CD247-ai-review.yaml	CD247	P20963	NCBITaxon:9606	Homo sapiens	114	R-HSA-9664406	T cell signaling regulation	yes	reactome/R-HSA-9664406.md	IgG:Lma antigens binds FCGR3A:CD3 dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - Reactome T cell signaling regulation.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	49	R-HSA-2316434	PI3K phosphorylation of PIP2 to PIP3 in CD28 signaling	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PI3K phosphorylation of PIP2 to PIP3 in context of CD28 signaling at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	50	R-HSA-2400009	PI3K inhibitors in CD28 signaling	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PI3K inhibitors blocking PI3K catalytic activity. CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	51	R-HSA-388814	Grb2 binding to CD28	yes	reactome/R-HSA-388814.md	Grb2 binds CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Grb2 binding to CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	52	R-HSA-388831	Phosphorylation of CD28	yes	reactome/R-HSA-388831.md	Phosphorylation of CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for phosphorylation of CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	53	R-HSA-388832	PI3K binding to CD28	yes	reactome/R-HSA-388832.md	PI3K binds CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PI3K binding to CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	54	R-HSA-389158	CD28-bound PI3K phosphorylation of PIP2 to PIP3	yes	reactome/R-HSA-389158.md	CD28 bound PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CD28-bound PI3K phosphorylating PIP2 to PIP3.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	55	R-HSA-389348	Activation of Rac1 by pVav1 in CD28 pathway	yes	reactome/R-HSA-389348.md	Activation of Rac1 by pVav1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for activation of Rac1 by pVav1 in the CD28 pathway at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	56	R-HSA-389350	Activation of Cdc42 by pVav1 in CD28 pathway	yes	reactome/R-HSA-389350.md	Activation of Cdc42 by pVav1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for activation of Cdc42 by pVav1 in the CD28 pathway at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	57	R-HSA-389352	Translocation of Vav1 to CD28	yes	reactome/R-HSA-389352.md	Translocation of Vav1 to CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for translocation of Vav1 to CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	58	R-HSA-389354	Activation of Vav1 in CD28 pathway	yes	reactome/R-HSA-389354.md	Activation of Vav1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for activation of Vav1 in the CD28 pathway at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	59	R-HSA-389381	Gads binding to CD28	yes	reactome/R-HSA-389381.md	Gads binds CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Gads binding to CD28 at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	60	R-HSA-167637	Internalization of Nef-CD28-Clathrin complex	yes	reactome/R-HSA-167637.md	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein complex. This is in the context of HIV Nef-mediated downregulation of CD28, where CD28 is internalized to the cytosol.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	64	R-HSA-167630	Formation of Nef-CD28 cytoplasmic tail complex	yes	reactome/R-HSA-167630.md	Formation of Nef CD28 cytoplasmic tail complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Formation of Nef-CD28 cytoplasmic tail complex at the plasma membrane (HIV Nef pathway).
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	65	R-HSA-167633	Formation of Nef-CD28-Clathrin-Coated Pit Adapter Protein complex	yes	reactome/R-HSA-167633.md	Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Formation of Nef:CD28:Clathrin-Coated Pit Adapter Protein complex at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	66	R-HSA-167637	Internalization of Nef-CD28-Clathrin complex	yes	reactome/R-HSA-167637.md	Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for internalization of the Nef:CD28:Clathrin complex from the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	67	R-HSA-388808	CD28 homodimer binding B7-2 monomer	yes	reactome/R-HSA-388808.md	CD28 homodimer binds B7-2 monomer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CD28 homodimer binding B7-2 monomer at the plasma membrane.
human	CD28	genes/human/CD28/CD28-ai-review.yaml	CD28	P10747	NCBITaxon:9606	Homo sapiens	68	R-HSA-388811	CD28 homodimer binding B7-1 homodimer	yes	reactome/R-HSA-388811.md	CD28 homodimer binds B7-1 homodimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CD28 homodimer binding B7-1 homodimer at the plasma membrane.
human	CD320	genes/human/CD320/CD320-ai-review.yaml	CD320	Q9NPF0	NCBITaxon:9606	Homo sapiens	7	R-HSA-9758890	Transport of RCbl within the body	yes	reactome/R-HSA-9758890.md	Transport of RCbl within the body	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation placing CD320 in cobalamin transport (transport of cobalamins within the body). This is a core biological process for CD320: it delivers TC-bound cobalamin into cells.
human	CD320	genes/human/CD320/CD320-ai-review.yaml	CD320	Q9NPF0	NCBITaxon:9606	Homo sapiens	17	R-HSA-3325546	Defective CD320 does not transport extracellular TCII:Cbl to endosome	yes	reactome/R-HSA-3325546.md	Defective CD320 does not transport extracellular TCII:Cbl to endosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS plasma-membrane annotation from the model of defective CD320 failing to transport TCII:Cbl to the endosome. Consistent with the receptor's cell-surface location.
human	CD320	genes/human/CD320/CD320-ai-review.yaml	CD320	Q9NPF0	NCBITaxon:9606	Homo sapiens	18	R-HSA-3000112	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000112.md	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS plasma-membrane annotation from the CD320-mediated TCN2:RCbl uptake and lysosomal delivery model, in which CD320 recycles to the plasma membrane after internalization.
human	CD320	genes/human/CD320/CD320-ai-review.yaml	CD320	Q9NPF0	NCBITaxon:9606	Homo sapiens	19	R-HSA-3000122	CD320 binds extracellular TCN2:RCbl	yes	reactome/R-HSA-3000122.md	CD320 binds extracellular TCN2:RCbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS plasma-membrane annotation from the ""CD320 binds extracellular TCN2:RCbl"" reaction. Consistent with the receptor capturing its ligand at the cell surface."
human	CD33	genes/human/CD33/CD33-ai-review.yaml	CD33	P20138	NCBITaxon:9606	Homo sapiens	34	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This intracellular or granule-membrane localization is compatible with CD33 biosynthesis, trafficking, or myeloid granule context, but it is not the main functional site of full-length CD33M inhibitory signaling.
human	CD33	genes/human/CD33/CD33-ai-review.yaml	CD33	P20138	NCBITaxon:9606	Homo sapiens	35	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This intracellular or granule-membrane localization is compatible with CD33 biosynthesis, trafficking, or myeloid granule context, but it is not the main functional site of full-length CD33M inhibitory signaling.
human	CD33	genes/human/CD33/CD33-ai-review.yaml	CD33	P20138	NCBITaxon:9606	Homo sapiens	36	R-HSA-5685607	Sialic acid binds SIGLEC	yes	reactome/R-HSA-5685607.md	Sialic acid binds SIGLEC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Full-length CD33M is a type I plasma membrane/external cell-surface receptor on myeloid cells.
human	CD33	genes/human/CD33/CD33-ai-review.yaml	CD33	P20138	NCBITaxon:9606	Homo sapiens	37	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Full-length CD33M is a type I plasma membrane/external cell-surface receptor on myeloid cells.
human	CD33	genes/human/CD33/CD33-ai-review.yaml	CD33	P20138	NCBITaxon:9606	Homo sapiens	38	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Full-length CD33M is a type I plasma membrane/external cell-surface receptor on myeloid cells.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	52	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CD47 is present on specific granule membranes in neutrophils, where it can be mobilized to the cell surface.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	53	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CD47 is present on tertiary granule membranes in neutrophils.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	54	R-HSA-202703	CD47 binds SIRP	yes	reactome/R-HSA-202703.md	CD47 binds SIRP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CD47 binding SIRP. Confirms plasma membrane localization.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	55	R-HSA-2426259	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47	yes	reactome/R-HSA-2426259.md	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for COMP binding to CD47. Confirms plasma membrane localization.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	56	R-HSA-391151	p-4Y-SIRPA:CD47:SKAP2 binds FYB	yes	reactome/R-HSA-391151.md	p-4Y-SIRPA:CD47:SKAP2 binds FYB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SIRPalpha-CD47 signaling.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	57	R-HSA-391152	p-4Y-SIRPA:CD47 binds PTK2B	yes	reactome/R-HSA-391152.md	p-4Y-SIRPA:CD47 binds PTK2B	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	58	R-HSA-391153	p-4Y-SIRPA:CD47 binds GRB2-1	yes	reactome/R-HSA-391153.md	p-4Y-SIRPA:CD47 binds GRB2-1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	59	R-HSA-391157	p-4Y-SIRPA:CD47 binds SKAP2	yes	reactome/R-HSA-391157.md	p-4Y-SIRPA:CD47 binds SKAP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	60	R-HSA-391158	SIRP alpha binds CD47	yes	reactome/R-HSA-391158.md	SIRP alpha binds CD47	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SIRPalpha binding CD47.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	61	R-HSA-391168	SIRP gamma binds CD47	yes	reactome/R-HSA-391168.md	SIRP gamma binds CD47	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SIRPgamma binding CD47.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	62	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	CD47	genes/human/CD47/CD47-ai-review.yaml	CD47	Q08722	NCBITaxon:9606	Homo sapiens	63	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	CD8A	genes/human/CD8A/CD8A-ai-review.yaml	CD8A	P01732	NCBITaxon:9606	Homo sapiens	29	R-HSA-198955	TCR complex interacts with peptide antigen-presenting MHC Class I	yes	reactome/R-HSA-198955.md	TCR complex interacts with peptide antigen-presenting MHC Class I	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane from Reactome pathway on TCR-MHC class I interaction.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular-region location derives from Reactome neutrophil tertiary-granule exocytosis. CDA is a cytosolic enzyme with no signal peptide; its appearance in the extracellular space reflects release during neutrophil degranulation, not its primary catalytic compartment.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	28	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular-region location from Reactome secretory-granule exocytosis; a degranulation-context localization for a normally cytosolic enzyme.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	29	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular-region location from Reactome ficolin-rich-granule exocytosis; a degranulation-context localization.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Secretory-granule-lumen localization from Reactome neutrophil-degranulation proteomics. Reflects CDA's presence in neutrophil granule stores rather than its primary cytosolic catalytic site.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	31	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Tertiary-granule-lumen localization from Reactome neutrophil-degranulation proteomics; a neutrophil granule-store localization.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	32	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Ficolin-1-rich-granule-lumen localization from Reactome neutrophil-degranulation proteomics; a neutrophil granule-store localization.
human	CDA	genes/human/CDA/CDA-ai-review.yaml	CDA	P32320	NCBITaxon:9606	Homo sapiens	33	R-HSA-73608	deamination of 2'-Deoxycytidine to 2'-Deoxyuridine	yes	reactome/R-HSA-73608.md	deamination of 2'-Deoxycytidine to 2'-Deoxyuridine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curates CDA as the cytosolic cytidine deaminase catalyzing deamination of cytidine/deoxycytidine. Cytosol is the correct core compartment.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	71	R-HSA-174122	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	yes	reactome/R-HSA-174122.md	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome compartment assignment (nucleoplasm) for reactions involving EMI1/FBXO5 phosphorylation and CDC20 association, and USP44 deubiquitination of CDC20.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	72	R-HSA-174174	Phosphorylation of the Emi1 DSGxxS degron by Plk1	yes	reactome/R-HSA-174174.md	Phosphorylation of the Emi1 DSGxxS degron by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome compartment assignment (nucleoplasm) for reactions involving EMI1/FBXO5 phosphorylation and CDC20 association, and USP44 deubiquitination of CDC20.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	73	R-HSA-174235	Association of Emi1 with Cdc20	yes	reactome/R-HSA-174235.md	Association of Emi1 with Cdc20	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome compartment assignment (nucleoplasm) for reactions involving EMI1/FBXO5 phosphorylation and CDC20 association, and USP44 deubiquitination of CDC20.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	74	R-HSA-5696958	USP44 deubiquitinates CDC20	yes	reactome/R-HSA-5696958.md	USP44 deubiquitinates CDC20	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome compartment assignment (nucleoplasm) for reactions involving EMI1/FBXO5 phosphorylation and CDC20 association, and USP44 deubiquitination of CDC20.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	81	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Mad1 binds kinetochore', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	82	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'MAD2 converted to an inhibitory state via interaction with Mad1', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	83	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Binding of the MCC complex to the APC/C complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	84	R-HSA-141429	Inactivation of APC/C via CDC20 sequestration	yes	reactome/R-HSA-141429.md	Inactivation of APC/C via CDC20 sequestration	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Inactivation of APC/C via CDC20 sequestration', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	85	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'MAD2 associates with the Mad1 kinetochore complex', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	86	R-HSA-141437	Formation of the MCC complex	yes	reactome/R-HSA-141437.md	Formation of the MCC complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Formation of the MCC complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	87	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Release of activated MAD2 from kinetochores', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	88	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Phosphorylation of cohesin by PLK1 at centromeres', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	89	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'PP2A-B56 dephosphorylates centromeric cohesin', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	90	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Association of cell cycle proteins with the APC/C:Cdh1 complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	91	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Ubiquitination of Cyclin A by APC/C:Cdc20 complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	92	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Degradation of multiubiquitinated cell cycle proteins', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	93	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Association of Cyclin B:Cdc2 with Cdc20:APC/C complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	94	R-HSA-174121	Association of Securin with Cdc20:APC/C complex	yes	reactome/R-HSA-174121.md	Association of Securin with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Association of Securin with Cdc20:APC/C complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	95	R-HSA-174144	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174144.md	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Ubiquitination of Securin by phospho-APC/C:Cdc20 complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	96	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Degradation of multiubiquitinated Cyclin B', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	97	R-HSA-174159	Ubiquitination of Emi1 by SCF-beta-TrCP	yes	reactome/R-HSA-174159.md	Ubiquitination of Emi1 by SCF-beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Ubiquitination of Emi1 by SCF-beta-TrCP', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	98	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Association of Cyclin A with the APC/C', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	99	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	100	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Degradation of multiubiquitinated Securin', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	101	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'SCF-mediated degradation of Emi1', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	102	R-HSA-174209	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	yes	reactome/R-HSA-174209.md	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Phosphorylated Emi1 binds the beta-TrCP in the SCF complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	103	R-HSA-174224	Dissociation of Cdc20 from APC/C complex	yes	reactome/R-HSA-174224.md	Dissociation of Cdc20 from APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Dissociation of Cdc20 from APC/C complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	104	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	105	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	106	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Degradation multiubiquitinated Cyclin A', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	107	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Association of Nek2A with MCC:APC/C', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	108	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Multiubiquitination of Nek2A', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	109	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Degradation of multiubiquitinated Nek2A', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	110	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'ESPL1 (Separase) cleaves centromeric cohesin', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	111	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Separation of sister chromatids', a reaction in which APC/C-CDC20 or the MCC-bound CDC20 participates directly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	112	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'CDK1 phosphorylates CDCA5 (Sororin) at centromeres', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	113	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Kinetochore assembly', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	114	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Kinetochore capture of astral microtubules', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	115	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'CDC42:GTP recruits DIAPH2-2 to kinetochores', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	116	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'AURKB phosphorylates DIAPH2-2 at kinetochores', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	117	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC20	genes/human/CDC20/CDC20-ai-review.yaml	CDC20	Q12834	NCBITaxon:9606	Homo sapiens	118	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome compartment assignment (cytosol) for 'EML4 recruits NUDC to mitotic spindle', a reaction in which CDC20 is present only as a constituent of a larger kinetochore/spindle or cohesin-regulatory assembly.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	31	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	TAS annotation from Reactome G2/M Transition pathway. CDC25B is a central component of this pathway.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	32	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0004721	phosphoprotein phosphatase activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome pathway for dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 complexes by Cdc25 phosphatases.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	33	R-HSA-170161	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	yes	reactome/R-HSA-170161.md	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	Homo sapiens	GO:0004721	phosphoprotein phosphatase activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome pathway for dephosphorylation of cytoplasmic Cyclin B1/B2: phospho-Cdc2 complexes specifically by CDC25B.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	34	R-HSA-9929935	CCNA:CDK1 phosphorylates CDC25B	yes	reactome/R-HSA-9929935.md	CCNA:CDK1 phosphorylates CDC25B	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway CCNA:CDK1 phosphorylates CDC25B, placing CDC25B in the nucleoplasm.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	37	R-HSA-8863007	p25-bound CDK5 phosphorylates CDC25B	yes	reactome/R-HSA-8863007.md	p25-bound CDK5 phosphorylates CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for p25-bound CDK5 phosphorylation of CDC25B, placing CDC25B in the cytosol.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	38	R-HSA-170120	Translocation of Cdc25B to the cytoplasm	yes	reactome/R-HSA-170120.md	Translocation of Cdc25B to the cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for translocation of Cdc25B to the cytoplasm, implying nucleoplasmic origin.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	39	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 complexes, placing CDC25B in nucleoplasm.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	40	R-HSA-170159	Translocation of Cdc25 to the nucleus	yes	reactome/R-HSA-170159.md	Translocation of Cdc25 to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for translocation of Cdc25 to the nucleus.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	41	R-HSA-9926524	MITF-M-dependent CDC25B gene expression	yes	reactome/R-HSA-9926524.md	MITF-M-dependent CDC25B gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for MITF-M-dependent CDC25B gene expression, placing CDC25B in the nucleoplasm.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	42	R-HSA-170120	Translocation of Cdc25B to the cytoplasm	yes	reactome/R-HSA-170120.md	Translocation of Cdc25B to the cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for translocation of Cdc25B to the cytoplasm.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	43	R-HSA-170159	Translocation of Cdc25 to the nucleus	yes	reactome/R-HSA-170159.md	Translocation of Cdc25 to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for translocation of Cdc25 to the nucleus, implying cytosolic origin before translocation.
human	CDC25B	genes/human/CDC25B/CDC25B-ai-review.yaml	CDC25B	P30305	NCBITaxon:9606	Homo sapiens	44	R-HSA-170161	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	yes	reactome/R-HSA-170161.md	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for dephosphorylation of cytoplasmic Cyclin B1/B2: phospho-Cdc2 complexes by CDC25B.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	5	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome TAS places CDC25C in the G2/M Transition pathway.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	6	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0004721	phosphoprotein phosphatase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for dephosphorylation of nuclear cyclin B1:phospho-CDK1 (Thr14/Tyr15) by CDC25 phosphatases.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	37	R-HSA-170149	Translocation of active Cdc25C to the nucleus	yes	reactome/R-HSA-170149.md	Translocation of active Cdc25C to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	38	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	39	R-HSA-170159	Translocation of Cdc25 to the nucleus	yes	reactome/R-HSA-170159.md	Translocation of Cdc25 to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	40	R-HSA-6798268	TP53 and E2F4 inhibit CDC25C expression	yes	reactome/R-HSA-6798268.md	TP53 and E2F4 inhibit CDC25C expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	41	R-HSA-6802973	PLK3 phosphorylates CDC25C	yes	reactome/R-HSA-6802973.md	PLK3 phosphorylates CDC25C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	42	R-HSA-75010	Phosphorylation of Cdc25C at Ser 216 by Chk1	yes	reactome/R-HSA-75010.md	Phosphorylation of Cdc25C at Ser 216 by Chk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	43	R-HSA-75809	Phosphorylation of Cdc25C at Ser216 by CHEK2	yes	reactome/R-HSA-75809.md	Phosphorylation of Cdc25C at Ser216 by CHEK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	44	R-HSA-9029987	p-S216-CDC25C translocates to the cytosol	yes	reactome/R-HSA-9029987.md	p-S216-CDC25C translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS nucleoplasm localization within G2/M-transition reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	48	R-HSA-156678	Activation of Cdc25C	yes	reactome/R-HSA-156678.md	Activation of Cdc25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (Activation of Cdc25C).
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	49	R-HSA-170149	Translocation of active Cdc25C to the nucleus	yes	reactome/R-HSA-170149.md	Translocation of active Cdc25C to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	50	R-HSA-170159	Translocation of Cdc25 to the nucleus	yes	reactome/R-HSA-170159.md	Translocation of Cdc25 to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	51	R-HSA-5671737	p-T774-PKN1 binds CDC25C	yes	reactome/R-HSA-5671737.md	p-T774-PKN1 binds CDC25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	52	R-HSA-5671749	p-T774-PKN1 phosphorylates CDC25C	yes	reactome/R-HSA-5671749.md	p-T774-PKN1 phosphorylates CDC25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	53	R-HSA-75016	Association of p-S216-CDC25C with 14-3-3 proteins	yes	reactome/R-HSA-75016.md	Association of p-S216-CDC25C with 14-3-3 proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	54	R-HSA-8863011	p25-bound CDK5 phosphorylates CDC25C	yes	reactome/R-HSA-8863011.md	p25-bound CDK5 phosphorylates CDC25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	55	R-HSA-8863674	CDC25C binds YWHAE (14-3-3-epsilon)	yes	reactome/R-HSA-8863674.md	CDC25C binds YWHAE (14-3-3-epsilon)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC25C	genes/human/CDC25C/CDC25C-ai-review.yaml	CDC25C	P30307	NCBITaxon:9606	Homo sapiens	56	R-HSA-9029987	p-S216-CDC25C translocates to the cytosol	yes	reactome/R-HSA-9029987.md	p-S216-CDC25C translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization within CDC25C regulatory reactions.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	51	R-HSA-174057	Multiubiquitination of APC/C-associated Cdh1	yes	reactome/R-HSA-174057.md	Multiubiquitination of APC/C-associated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	52	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	53	R-HSA-174079	Phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	54	R-HSA-174119	Free APC/C phosphorylated by Plk1	yes	reactome/R-HSA-174119.md	Free APC/C phosphorylated by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	55	R-HSA-174132	Free APC/C phosphorylated by Cyclin B:Cdc2	yes	reactome/R-HSA-174132.md	Free APC/C phosphorylated by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	56	R-HSA-174139	Dissociation of phospho-Cdh1 from the APC/C complex	yes	reactome/R-HSA-174139.md	Dissociation of phospho-Cdh1 from the APC/C complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	57	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	58	R-HSA-188371	Association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-188371.md	Association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	59	R-HSA-3788705	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	60	R-HSA-3788708	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-3788708.md	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	61	R-HSA-3788724	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	yes	reactome/R-HSA-3788724.md	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	62	R-HSA-3788725	Cdh1:APC/C complex binds EHMT1:EHMT2	yes	reactome/R-HSA-3788725.md	Cdh1:APC/C complex binds EHMT1:EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	63	R-HSA-68712	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	yes	reactome/R-HSA-68712.md	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	64	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	65	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	66	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this APC/C-CDH1 reaction (coactivator loading/turnover, geminin, SKP2, EHMT1/2 and cyclin A/CDK2-CDH1 events) in the nucleoplasm, where the interphase APC/C-CDH1 acts from anaphase through G1.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	77	R-HSA-141423	Binding of the MCC complex to the APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	78	R-HSA-174070	Association of Cdh1 with the APC/C	yes	reactome/R-HSA-174070.md	Association of Cdh1 with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	79	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	80	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	81	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	82	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	83	R-HSA-174121	Association of Securin with Cdc20:APC/C complex	yes	reactome/R-HSA-174121.md	Association of Securin with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	84	R-HSA-174144	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174144.md	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	85	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	86	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	87	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	88	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	89	R-HSA-174224	Dissociation of Cdc20 from APC/C complex	yes	reactome/R-HSA-174224.md	Dissociation of Cdc20 from APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	90	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	91	R-HSA-174238	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	92	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	93	R-HSA-179410	Association of Nek2A with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	94	R-HSA-179417	Multiubiquitination of Nek2A	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	95	R-HSA-179421	Degradation of multiubiquitinated Nek2A	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC27	genes/human/CDC27/CDC27-ai-review.yaml	CDC27	P30260	NCBITaxon:9606	Homo sapiens	96	R-HSA-69015	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	yes	reactome/R-HSA-69015.md	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this mitotic APC/C event (phosphorylation of the free APC/C, CDC20/MCC binding, ubiquitination and degradation of securin, cyclin A, cyclin B and NEK2A, and CDC6/CDH1 events) in the cytosol, where the APC/C-CDC20 ligase acts after nuclear-envelope breakdown.
human	CDC37L1	genes/human/CDC37L1/CDC37L1-ai-review.yaml	CDC37L1	Q7L3B6	NCBITaxon:9606	Homo sapiens	14	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation derived from detection of CDC37L1 in platelet dense granule releasate/exocytosis. This reflects a specialized platelet-biology context, not CDC37L1's core cytoplasmic co-chaperone function.
human	CDC37L1	genes/human/CDC37L1/CDC37L1-ai-review.yaml	CDC37L1	Q7L3B6	NCBITaxon:9606	Homo sapiens	15	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0031089	platelet dense granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing CDC37L1 in the platelet dense granule lumen based on platelet exocytosis pathway curation. This is a specialized context distinct from its core cytoplasmic chaperone role.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	89	R-HSA-9935547	Lysosomal degradation of ubiquitinated CDH1	yes	reactome/R-HSA-9935547.md	Lysosomal degradation of ubiquitinated CDH1	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9935547): Endocytosed, ubiquitinated CDH1/E-cadherin is sorted to lysosomes for degradation as part of junction turnover and downregulation. Lysosomal localization is real but reflects CDH1 degradative turnover rather than the site of its core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	90	R-HSA-9935552	Ubiquitinated CDH1 translocates to lysosomes for degradation	yes	reactome/R-HSA-9935552.md	Ubiquitinated CDH1 translocates to lysosomes for degradation	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9935552): Endocytosed, ubiquitinated CDH1/E-cadherin is sorted to lysosomes for degradation as part of junction turnover and downregulation. Lysosomal localization is real but reflects CDH1 degradative turnover rather than the site of its core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	91	R-HSA-9934752	Ubiquitinated CDH1 is endocytosed	yes	reactome/R-HSA-9934752.md	Ubiquitinated CDH1 is endocytosed	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934752): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	92	R-HSA-9934753	CBLL1 ubiquitinates CDH1	yes	reactome/R-HSA-9934753.md	CBLL1 ubiquitinates CDH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934753): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	93	R-HSA-9934752	Ubiquitinated CDH1 is endocytosed	yes	reactome/R-HSA-9934752.md	Ubiquitinated CDH1 is endocytosed	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9934752): CDH1/E-cadherin undergoes clathrin-mediated endocytosis and is trafficked through early endosomes during junction remodelling, recycling, and degradative sorting (e.g. following CBLL1/Hakai-mediated ubiquitination). Early endosome localization is real but reflects CDH1 trafficking/turnover rather than the site of its core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA endosome annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	94	R-HSA-9935552	Ubiquitinated CDH1 translocates to lysosomes for degradation	yes	reactome/R-HSA-9935552.md	Ubiquitinated CDH1 translocates to lysosomes for degradation	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9935552): CDH1/E-cadherin undergoes clathrin-mediated endocytosis and is trafficked through early endosomes during junction remodelling, recycling, and degradative sorting (e.g. following CBLL1/Hakai-mediated ubiquitination). Early endosome localization is real but reflects CDH1 trafficking/turnover rather than the site of its core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA endosome annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	95	R-HSA-9934751	CDH1 is phosphorylated on tyrosine residues	yes	reactome/R-HSA-9934751.md	CDH1 is phosphorylated on tyrosine residues	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934751): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	96	R-HSA-9934755	CBLL1 binds p-Y-CDH1	yes	reactome/R-HSA-9934755.md	CBLL1 binds p-Y-CDH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934755): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	97	R-HSA-9766227	MDM2 mediates CDH1 ubiquitination	yes	reactome/R-HSA-9766227.md	MDM2 mediates CDH1 ubiquitination	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9766227): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	98	R-HSA-9934584	The complex of MDM2 and CDH1 translocates to early endosomes	yes	reactome/R-HSA-9934584.md	The complex of MDM2 and CDH1 translocates to early endosomes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934584): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	99	R-HSA-9766223	Proteasome-dependent degradation of ubiquitinated CDH1	yes	reactome/R-HSA-9766223.md	Proteasome-dependent degradation of ubiquitinated CDH1	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9766223): CDH1/E-cadherin undergoes clathrin-mediated endocytosis and is trafficked through early endosomes during junction remodelling, recycling, and degradative sorting (e.g. following CBLL1/Hakai-mediated ubiquitination). Early endosome localization is real but reflects CDH1 trafficking/turnover rather than the site of its core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA endosome annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	100	R-HSA-9934584	The complex of MDM2 and CDH1 translocates to early endosomes	yes	reactome/R-HSA-9934584.md	The complex of MDM2 and CDH1 translocates to early endosomes	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9934584): CDH1/E-cadherin undergoes clathrin-mediated endocytosis and is trafficked through early endosomes during junction remodelling, recycling, and degradative sorting (e.g. following CBLL1/Hakai-mediated ubiquitination). Early endosome localization is real but reflects CDH1 trafficking/turnover rather than the site of its core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA endosome annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	101	R-HSA-9766219	MDM2 binds CDH1	yes	reactome/R-HSA-9766219.md	MDM2 binds CDH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9766219): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	102	R-HSA-9816278	CDH1 translocates to the plasma membrane	yes	reactome/R-HSA-9816278.md	CDH1 translocates to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9816278): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	103	R-HSA-9817325	CDH1 associates with CTNND1	yes	reactome/R-HSA-9817325.md	CDH1 associates with CTNND1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9817325): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	104	R-HSA-9817330	CDH1:CTNNB1 complex binds CTNNA1	yes	reactome/R-HSA-9817330.md	CDH1:CTNNB1 complex binds CTNNA1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9817330): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	105	R-HSA-9934294	CDH1-associated CTNNA1 binds VCL	yes	reactome/R-HSA-9934294.md	CDH1-associated CTNNA1 binds VCL	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934294): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	106	R-HSA-9934410	CDH1 forms homotypic trans-dimers	yes	reactome/R-HSA-9934410.md	CDH1 forms homotypic trans-dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934410): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	107	R-HSA-9934411	CDH1 forms cis-clusters	yes	reactome/R-HSA-9934411.md	CDH1 forms cis-clusters	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934411): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	108	R-HSA-9934486	CDH1-associated CTNNA1 binds F-actin	yes	reactome/R-HSA-9934486.md	CDH1-associated CTNNA1 binds F-actin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9934486): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	109	R-HSA-9816275	CDH1 is proteolytically cleaved in Golgi	yes	reactome/R-HSA-9816275.md	CDH1 is proteolytically cleaved in Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816275): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	110	R-HSA-9816278	CDH1 translocates to the plasma membrane	yes	reactome/R-HSA-9816278.md	CDH1 translocates to the plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816278): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	111	R-HSA-9934330	CDH1:CTNNB1,JUP complex binds to ANK3	yes	reactome/R-HSA-9934330.md	CDH1:CTNNB1,JUP complex binds to ANK3	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9934330): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	112	R-HSA-9935209	CDH1 binds to PIP5K1C	yes	reactome/R-HSA-9935209.md	CDH1 binds to PIP5K1C	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9935209): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	113	R-HSA-9816275	CDH1 is proteolytically cleaved in Golgi	yes	reactome/R-HSA-9816275.md	CDH1 is proteolytically cleaved in Golgi	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816275): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	114	R-HSA-9816273	CDH1 translocates from ER to Golgi	yes	reactome/R-HSA-9816273.md	CDH1 translocates from ER to Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816273): CDH1/E-cadherin transits and is further processed/glycosylated in the Golgi apparatus en route from the ER to the plasma membrane. Golgi localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function. Consistent with KEEP_AS_NON_CORE on the IEA Golgi apparatus annotation in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	115	R-HSA-9816273	CDH1 translocates from ER to Golgi	yes	reactome/R-HSA-9816273.md	CDH1 translocates from ER to Golgi	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816273): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	116	R-HSA-9933194	CTNNB1, JUP bind CDH1	yes	reactome/R-HSA-9933194.md	CTNNB1, JUP bind CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9933194): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	117	R-HSA-9933380	Cytosolic tail of CDH1 is phosphorylated	yes	reactome/R-HSA-9933380.md	Cytosolic tail of CDH1 is phosphorylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9933380): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	118	R-HSA-9816277	CDH1 is O-manosylated	yes	reactome/R-HSA-9816277.md	CDH1 is O-manosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816277): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	119	R-HSA-9932352	Glucosidase II removes glucose residue from Glu2Man9GlucNAc2-CDH1	yes	reactome/R-HSA-9932352.md	Glucosidase II removes glucose residue from Glu2Man9GlucNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932352): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	120	R-HSA-9932913	Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1	yes	reactome/R-HSA-9932913.md	Glucosidase II removes glucose residue from Glu1Man9GlucNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932913): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	121	R-HSA-9932988	CANX binds Glu1Man9GlcNAc2-CDH1	yes	reactome/R-HSA-9932988.md	CANX binds Glu1Man9GlcNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932988): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	122	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9816276): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	123	R-HSA-9932344	MOGS removes terminal glucose from Glu3Man9GlcNAc2-CDH1	yes	reactome/R-HSA-9932344.md	MOGS removes terminal glucose from Glu3Man9GlcNAc2-CDH1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932344): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	124	R-HSA-9932162	Removal of CDH1 signal peptide	yes	reactome/R-HSA-9932162.md	Removal of CDH1 signal peptide	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932162): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	125	R-HSA-9932162	Removal of CDH1 signal peptide	yes	reactome/R-HSA-9932162.md	Removal of CDH1 signal peptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9932162): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	137	R-HSA-9768614	miR-9 inhibits CDH1 mRNA translation	yes	reactome/R-HSA-9768614.md	miR-9 inhibits CDH1 mRNA translation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9768614): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	138	R-HSA-9768618	miR-10b inhibits CDH1 mRNA translation	yes	reactome/R-HSA-9768618.md	miR-10b inhibits CDH1 mRNA translation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome (R-HSA-9768618): As a secretory-pathway transmembrane glycoprotein, pro-CDH1/E-cadherin is co-translationally inserted into, N-glycosylated, and folded within the endoplasmic reticulum before transport to the Golgi and plasma membrane. ER localization is real but represents a transient biosynthetic/processing compartment rather than the site of CDH1 core adhesion function.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	149	R-HSA-8876948	SRC phosphorylates InlA-bound CDH1 and CTNNB1	yes	reactome/R-HSA-8876948.md	SRC phosphorylates InlA-bound CDH1 and CTNNB1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-8876948): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	150	R-HSA-8876993	CBLL1 binds SRC-phosphorylated CDH1 complex	yes	reactome/R-HSA-8876993.md	CBLL1 binds SRC-phosphorylated CDH1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-8876993): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	151	R-HSA-8877003	CBLL1 ubiqutinates the InlA-bound CDH1 complex	yes	reactome/R-HSA-8877003.md	CBLL1 ubiqutinates the InlA-bound CDH1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-8877003): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	160	R-HSA-3827958	E-cadherin degradation by MMP9, KLK7	yes	reactome/R-HSA-3827958.md	E-cadherin degradation by MMP9, KLK7	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-3827958): CDH1/E-cadherin has a large N-terminal ectodomain (EC1-EC5) that occupies the extracellular space, and proteolytic shedding (e.g. by MMP9/KLK7) releases a soluble extracellular ectodomain fragment. Consistent with the extracellular region annotation ACCEPTed on IEA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	161	R-HSA-4224014	E-cadherin degradation by ADAM10, ADAM15	yes	reactome/R-HSA-4224014.md	E-cadherin degradation by ADAM10, ADAM15	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-4224014): CDH1/E-cadherin has a large N-terminal ectodomain (EC1-EC5) that occupies the extracellular space, and proteolytic shedding (e.g. by MMP9/KLK7) releases a soluble extracellular ectodomain fragment. Consistent with the extracellular region annotation ACCEPTed on IEA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	162	R-HSA-3827958	E-cadherin degradation by MMP9, KLK7	yes	reactome/R-HSA-3827958.md	E-cadherin degradation by MMP9, KLK7	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-3827958): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	163	R-HSA-4224014	E-cadherin degradation by ADAM10, ADAM15	yes	reactome/R-HSA-4224014.md	E-cadherin degradation by ADAM10, ADAM15	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-4224014): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	164	R-NUL-2534209	E-cadherin strand dimer degradation by PS1	yes	reactome/R-NUL-2534209.md	E-cadherin strand dimer degradation by PS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-NUL-2534209): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	165	R-HSA-202939	Caspase-mediated cleavage of E-Cadherin	yes	reactome/R-HSA-202939.md	Caspase-mediated cleavage of E-Cadherin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-202939): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	166	R-HSA-265422	Interaction of integrin alphaEbeta7 with Cadherin-1	yes	reactome/R-HSA-265422.md	Interaction of integrin alphaEbeta7 with Cadherin-1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-265422): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	167	R-HSA-419001	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin	yes	reactome/R-HSA-419001.md	Connection of adjacent cells through calcium-dependent trans-dimerization of cadherin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-419001): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	168	R-HSA-419002	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin	yes	reactome/R-HSA-419002.md	Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-419002): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	169	R-HSA-5672304	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1	yes	reactome/R-HSA-5672304.md	IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-5672304): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	170	R-HSA-8876497	InlA binds CDH1	yes	reactome/R-HSA-8876497.md	InlA binds CDH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-8876497): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	171	R-HSA-9825774	SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development	yes	reactome/R-HSA-9825774.md	SNAI2 and TBX3 repress CDH1 gene expression during melanocyte development	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9825774): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDH1	genes/human/CDH1/CDH1-ai-review.yaml	CDH1	P12830	NCBITaxon:9606	Homo sapiens	172	R-HSA-9926527	MITF-M-dependent CDH1 gene expression	yes	reactome/R-HSA-9926527.md	MITF-M-dependent CDH1 gene expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (R-HSA-9926527): The plasma membrane is the primary steady-state localization of CDH1/E-cadherin. As a type-I single-pass transmembrane glycoprotein, mature E-cadherin resides at the lateral/basolateral plasma membrane of epithelial cells, where it mediates calcium-dependent homophilic trans-dimerisation and cell-cell adhesion. Consistent with the plasma membrane annotations ACCEPTed on IEA and IDA evidence elsewhere in this file.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	90	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	G2/M transition is THE core function of CDK1. It is uniquely required among all CDKs for mammalian cell division.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	91	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	CDK1 is not a deubiquitinase. This annotation likely reflects CDK1's role in a pathway involving deubiquitination, not direct activity.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	92	R-HSA-110056	MAPK3 (ERK1) activation	yes	reactome/R-HSA-110056.md	MAPK3 (ERK1) activation	Homo sapiens	GO:0070371	ERK1 and ERK2 cascade	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	CDK1 can phosphorylate MAP2K1 (MEK1) contributing to ERK cascade regulation, but this is not its core function.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	93	R-HSA-112342	Inactivation of MAP2K1 by CDK1	yes	reactome/R-HSA-112342.md	Inactivation of MAP2K1 by CDK1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK1 is a serine/threonine kinase that phosphorylates S/T-P motifs. This is well-established biochemically.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	94	R-HSA-8940100	CDK1 phosphorylates VCPIP1	yes	reactome/R-HSA-8940100.md	CDK1 phosphorylates VCPIP1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK1 is a serine/threonine kinase that phosphorylates S/T-P motifs. This is well-established biochemically.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	95	R-HSA-4088024	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	yes	reactome/R-HSA-4088024.md	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	96	R-HSA-5692755	CDK1 phosphorylates MAPK6	yes	reactome/R-HSA-5692755.md	CDK1 phosphorylates MAPK6	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	97	R-HSA-9929514	CDK1 phosphorylates CCNA	yes	reactome/R-HSA-9929514.md	CDK1 phosphorylates CCNA	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	98	R-HSA-9929532	CCNA:CDK1 phosphorylates BORA	yes	reactome/R-HSA-9929532.md	CCNA:CDK1 phosphorylates BORA	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	99	R-HSA-9929535	CCNA:CDK1 phosphorylates WEE1	yes	reactome/R-HSA-9929535.md	CCNA:CDK1 phosphorylates WEE1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	100	R-HSA-9929717	CCNA:CDK1 phosphorylates FZR1	yes	reactome/R-HSA-9929717.md	CCNA:CDK1 phosphorylates FZR1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	101	R-HSA-9929719	CCNA:CDK1 phosphorylates TICRR	yes	reactome/R-HSA-9929719.md	CCNA:CDK1 phosphorylates TICRR	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	102	R-HSA-9929720	CCNA:CDK1 phosphorylates OBI1	yes	reactome/R-HSA-9929720.md	CCNA:CDK1 phosphorylates OBI1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	103	R-HSA-9929721	CCNA:CDK1 phosphorylates SGO1	yes	reactome/R-HSA-9929721.md	CCNA:CDK1 phosphorylates SGO1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	104	R-HSA-9929884	CCNA:CDK1 phosphorylates HJURP	yes	reactome/R-HSA-9929884.md	CCNA:CDK1 phosphorylates HJURP	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	105	R-HSA-9929904	CCNA:CDK1 phosphorylates MIS18BP1	yes	reactome/R-HSA-9929904.md	CCNA:CDK1 phosphorylates MIS18BP1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	106	R-HSA-9929935	CCNA:CDK1 phosphorylates CDC25B	yes	reactome/R-HSA-9929935.md	CCNA:CDK1 phosphorylates CDC25B	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	This is the most appropriate molecular function term for CDK1. The enzyme requires cyclin binding for activity and phosphorylates serine/threonine residues.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	134	R-HSA-9836184	p-PKR dimer phosphorylates CDK1	yes	reactome/R-HSA-9836184.md	p-PKR dimer phosphorylates CDK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	161	R-HSA-8940100	CDK1 phosphorylates VCPIP1	yes	reactome/R-HSA-8940100.md	CDK1 phosphorylates VCPIP1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	CDK1 may localize to ER membrane in some contexts.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	179	R-HSA-170044	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	yes	reactome/R-HSA-170044.md	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	180	R-HSA-170070	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	yes	reactome/R-HSA-170070.md	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	181	R-HSA-170072	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	yes	reactome/R-HSA-170072.md	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	182	R-HSA-170153	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	yes	reactome/R-HSA-170153.md	Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	183	R-HSA-170156	WEE1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170156.md	WEE1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	184	R-HSA-170158	CDC25A dephosphorylates CCNA:CDK1	yes	reactome/R-HSA-170158.md	CDC25A dephosphorylates CCNA:CDK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	185	R-HSA-170044	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	yes	reactome/R-HSA-170044.md	Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	186	R-HSA-170072	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	yes	reactome/R-HSA-170072.md	Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	187	R-HSA-170161	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	yes	reactome/R-HSA-170161.md	Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	188	R-HSA-170131	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	yes	reactome/R-HSA-170131.md	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	189	R-HSA-174122	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	yes	reactome/R-HSA-174122.md	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	190	R-HSA-174132	Free APC/C phosphorylated by Cyclin B:Cdc2	yes	reactome/R-HSA-174132.md	Free APC/C phosphorylated by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	191	R-HSA-174251	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	yes	reactome/R-HSA-174251.md	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	192	R-HSA-2245218	CDK1 phosphorylates PHF8	yes	reactome/R-HSA-2245218.md	CDK1 phosphorylates PHF8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	193	R-HSA-2294600	CDK1 phosphorylates condensin II subunit NCAPD3	yes	reactome/R-HSA-2294600.md	CDK1 phosphorylates condensin II subunit NCAPD3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	194	R-HSA-380278	CCNB1:p-T160-CDK1 phosphorylates NUMA1	yes	reactome/R-HSA-380278.md	CCNB1:p-T160-CDK1 phosphorylates NUMA1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	195	R-HSA-4088024	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	yes	reactome/R-HSA-4088024.md	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	196	R-HSA-5195402	CDK1 phosphorylates LPIN	yes	reactome/R-HSA-5195402.md	CDK1 phosphorylates LPIN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	197	R-HSA-5244669	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments	yes	reactome/R-HSA-5244669.md	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	198	R-HSA-5692755	CDK1 phosphorylates MAPK6	yes	reactome/R-HSA-5692755.md	CDK1 phosphorylates MAPK6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	199	R-HSA-6793661	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218	yes	reactome/R-HSA-6793661.md	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	200	R-HSA-9009282	CDK1 phosphorylates RUNX2	yes	reactome/R-HSA-9009282.md	CDK1 phosphorylates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	201	R-HSA-9929514	CDK1 phosphorylates CCNA	yes	reactome/R-HSA-9929514.md	CDK1 phosphorylates CCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	202	R-HSA-9929533	CCNA:CDK1 complex translocates to the cytosol	yes	reactome/R-HSA-9929533.md	CCNA:CDK1 complex translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	203	R-HSA-9929535	CCNA:CDK1 phosphorylates WEE1	yes	reactome/R-HSA-9929535.md	CCNA:CDK1 phosphorylates WEE1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	204	R-HSA-9929717	CCNA:CDK1 phosphorylates FZR1	yes	reactome/R-HSA-9929717.md	CCNA:CDK1 phosphorylates FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	205	R-HSA-9929719	CCNA:CDK1 phosphorylates TICRR	yes	reactome/R-HSA-9929719.md	CCNA:CDK1 phosphorylates TICRR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	206	R-HSA-9929720	CCNA:CDK1 phosphorylates OBI1	yes	reactome/R-HSA-9929720.md	CCNA:CDK1 phosphorylates OBI1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	207	R-HSA-9929721	CCNA:CDK1 phosphorylates SGO1	yes	reactome/R-HSA-9929721.md	CCNA:CDK1 phosphorylates SGO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	208	R-HSA-9929884	CCNA:CDK1 phosphorylates HJURP	yes	reactome/R-HSA-9929884.md	CCNA:CDK1 phosphorylates HJURP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	209	R-HSA-9929904	CCNA:CDK1 phosphorylates MIS18BP1	yes	reactome/R-HSA-9929904.md	CCNA:CDK1 phosphorylates MIS18BP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	210	R-HSA-9929935	CCNA:CDK1 phosphorylates CDC25B	yes	reactome/R-HSA-9929935.md	CCNA:CDK1 phosphorylates CDC25B	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	211	R-NUL-2434198	CDK1 phosphorylates Mastl	yes	reactome/R-NUL-2434198.md	CDK1 phosphorylates Mastl	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	212	R-HSA-112342	Inactivation of MAP2K1 by CDK1	yes	reactome/R-HSA-112342.md	Inactivation of MAP2K1 by CDK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	213	R-HSA-170126	Phosphorylation of Cyclin B1 in the CRS domain	yes	reactome/R-HSA-170126.md	Phosphorylation of Cyclin B1 in the CRS domain	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	214	R-HSA-170131	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	yes	reactome/R-HSA-170131.md	Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	215	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	216	R-HSA-174120	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	yes	reactome/R-HSA-174120.md	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	217	R-HSA-174157	Degradation of multiubiquitinated Cyclin B	yes	reactome/R-HSA-174157.md	Degradation of multiubiquitinated Cyclin B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	218	R-HSA-174171	Association of Cyclin A with the APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	219	R-HSA-174227	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174227.md	Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	220	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	221	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	222	R-HSA-2468293	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	yes	reactome/R-HSA-2468293.md	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	223	R-HSA-2984220	CDK1:CCNB phosphorylates NEK9	yes	reactome/R-HSA-2984220.md	CDK1:CCNB phosphorylates NEK9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	224	R-HSA-2990882	CDK1 phosphorylates NUP98	yes	reactome/R-HSA-2990882.md	CDK1 phosphorylates NUP98	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	225	R-HSA-4086410	CCNB:CDK1 phosphorylates BORA	yes	reactome/R-HSA-4086410.md	CCNB:CDK1 phosphorylates BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	226	R-HSA-9624800	CDK1 phosphorylates LBR	yes	reactome/R-HSA-9624800.md	CDK1 phosphorylates LBR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	227	R-HSA-9929532	CCNA:CDK1 phosphorylates BORA	yes	reactome/R-HSA-9929532.md	CCNA:CDK1 phosphorylates BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	228	R-HSA-9929533	CCNA:CDK1 complex translocates to the cytosol	yes	reactome/R-HSA-9929533.md	CCNA:CDK1 complex translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	229	R-NUL-2422970	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB	yes	reactome/R-NUL-2422970.md	Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	230	R-HSA-170076	CAK phosphorylates CDK1 bound to CCNB1	yes	reactome/R-HSA-170076.md	CAK phosphorylates CDK1 bound to CCNB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	231	R-HSA-170087	CAK phosphorylates CDK1 bound to CCNA	yes	reactome/R-HSA-170087.md	CAK phosphorylates CDK1 bound to CCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	232	R-HSA-170088	Translocation of CCNA:p-T14-CDK1 to the nucleus	yes	reactome/R-HSA-170088.md	Translocation of CCNA:p-T14-CDK1 to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the nucleoplasm. Consistent with its nuclear functions.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	233	R-HSA-170055	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170055.md	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	234	R-HSA-170057	Formation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170057.md	Formation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	235	R-HSA-170088	Translocation of CCNA:p-T14-CDK1 to the nucleus	yes	reactome/R-HSA-170088.md	Translocation of CCNA:p-T14-CDK1 to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	236	R-HSA-170116	PKMYT1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170116.md	PKMYT1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	237	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	238	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	239	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	240	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	241	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	242	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	243	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	244	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	245	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	246	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	247	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	248	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	249	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	250	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	251	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	252	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	253	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	254	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	255	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	256	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	257	R-HSA-6803875	SFN dimer binds CDK1 and CCNB1	yes	reactome/R-HSA-6803875.md	SFN dimer binds CDK1 and CCNB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	258	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	259	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	260	R-HSA-9928875	Formation of CCNA1:CDK1 complex	yes	reactome/R-HSA-9928875.md	Formation of CCNA1:CDK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK1	genes/human/CDK1/CDK1-ai-review.yaml	CDK1	P06493	NCBITaxon:9606	Homo sapiens	261	R-HSA-9928887	Formation of CCNA2:CDK1 complex	yes	reactome/R-HSA-9928887.md	Formation of CCNA2:CDK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDK1 localizes to the cytosol. Well-established localization.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	92	R-HSA-68911	Reactome:R-HSA-68911	yes	reactome/R-HSA-68911.md	G2 Phase	Homo sapiens	GO:0007346	regulation of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	Regulation of the mitotic cell cycle (Reactome TAS).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	93	R-HSA-69656	Reactome:R-HSA-69656	yes	reactome/R-HSA-69656.md	Cyclin A:Cdk2-associated events at S phase entry	Homo sapiens	GO:0045740	positive regulation of DNA replication	TAS	involved_in	BP	false		ACCEPT	Positive regulation of DNA replication by cyclin-CDK2 (Reactome TAS).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	94	R-HSA-2559583	Reactome:R-HSA-2559583	yes	reactome/R-HSA-2559583.md	Cellular Senescence	Homo sapiens	GO:0090398	cellular senescence	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Cellular senescence: cyclin E/CDK2-mediated MYC phosphorylation suppresses Ras-induced senescence (Reactome TAS).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	95	R-HSA-176408	Reactome:R-HSA-176408	yes	reactome/R-HSA-176408.md	Regulation of APC/C activators between G1/S and early anaphase	Homo sapiens	GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Regulation of APC/C-dependent catabolism: CDK2 activates USP37 to antagonize APC/C-CDH1 and promote S-phase entry.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	96	R-HSA-174079	Reactome:R-HSA-174079	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK2 is a cyclin-dependent serine/threonine protein kinase (EC 2.7.11.22); this is its defining, well-established molecular function, active only when bound to a cyclin partner.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	97	R-HSA-187520	Reactome:R-HSA-187520	yes	reactome/R-HSA-187520.md	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK2 is a cyclin-dependent serine/threonine protein kinase (EC 2.7.11.22); this is its defining, well-established molecular function, active only when bound to a cyclin partner.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	98	R-HSA-187959	Reactome:R-HSA-187959	yes	reactome/R-HSA-187959.md	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK2 is a cyclin-dependent serine/threonine protein kinase (EC 2.7.11.22); this is its defining, well-established molecular function, active only when bound to a cyclin partner.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	99	R-HSA-188390	Reactome:R-HSA-188390	yes	reactome/R-HSA-188390.md	Cyclin E:CDK2-mediated phosphorylation of RB1	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK2 is a cyclin-dependent serine/threonine protein kinase (EC 2.7.11.22); this is its defining, well-established molecular function, active only when bound to a cyclin partner.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	100	R-HSA-3788705	Reactome:R-HSA-3788705	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	CDK2 is a cyclin-dependent serine/threonine protein kinase (EC 2.7.11.22); this is its defining, well-established molecular function, active only when bound to a cyclin partner.
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	149	R-HSA-157906	Reactome:R-HSA-157906	yes	reactome/R-HSA-157906.md	Translocation of Cyclin E:Cdk2 complex to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization (Reactome pathway annotation).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	150	R-HSA-174054	Reactome:R-HSA-174054	yes	reactome/R-HSA-174054.md	Formation of Cyclin A:Cdk2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization (Reactome pathway annotation).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	151	R-HSA-174273	Reactome:R-HSA-174273	yes	reactome/R-HSA-174273.md	Translocation of Cyclin A:Cdk2 complexes to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization (Reactome pathway annotation).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	152	R-HSA-69191	Reactome:R-HSA-69191	yes	reactome/R-HSA-69191.md	Formation of Cyclin E:Cdk2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization (Reactome pathway annotation).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	153	R-HSA-9858566	Reactome:R-HSA-9858566	yes	reactome/R-HSA-9858566.md	MITF-M-dependent CDK2 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization (Reactome pathway annotation).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	154	R-HSA-1363303	Reactome:R-HSA-1363303	yes	reactome/R-HSA-1363303.md	p130 (RBL2) in complex with E2F4/5:DP1/2 binds to cyclin E/A:CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	155	R-HSA-1363306	Reactome:R-HSA-1363306	yes	reactome/R-HSA-1363306.md	p130 (RBL2) binds Cyclin E/A:CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	156	R-HSA-1363311	Reactome:R-HSA-1363311	yes	reactome/R-HSA-1363311.md	p107 (RBL1) in complex with E2F4:DP1/2 binds to cyclin E/A:CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	157	R-HSA-1363314	Reactome:R-HSA-1363314	yes	reactome/R-HSA-1363314.md	p107 (RBL1) binds CyclinE/A:CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	158	R-HSA-157906	Reactome:R-HSA-157906	yes	reactome/R-HSA-157906.md	Translocation of Cyclin E:Cdk2 complex to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	159	R-HSA-174079	Reactome:R-HSA-174079	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	160	R-HSA-174110	Reactome:R-HSA-174110	yes	reactome/R-HSA-174110.md	Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	161	R-HSA-174164	Reactome:R-HSA-174164	yes	reactome/R-HSA-174164.md	Phosphorylation of Cyclin A:Cdk2 at Tyr 15	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	162	R-HSA-174273	Reactome:R-HSA-174273	yes	reactome/R-HSA-174273.md	Translocation of Cyclin A:Cdk2 complexes to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	163	R-HSA-176298	Reactome:R-HSA-176298	yes	reactome/R-HSA-176298.md	Activation of claspin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	164	R-HSA-176318	Reactome:R-HSA-176318	yes	reactome/R-HSA-176318.md	Loading of claspin onto DNA during replication origin firing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	165	R-HSA-187520	Reactome:R-HSA-187520	yes	reactome/R-HSA-187520.md	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	166	R-HSA-187552	Reactome:R-HSA-187552	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	167	R-HSA-187574	Reactome:R-HSA-187574	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	168	R-HSA-187575	Reactome:R-HSA-187575	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	169	R-HSA-187916	Reactome:R-HSA-187916	yes	reactome/R-HSA-187916.md	Cyclin A:Cdk2 mediated phosphorylation of p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	170	R-HSA-187934	Reactome:R-HSA-187934	yes	reactome/R-HSA-187934.md	Inactivation of Cyclin A:Cdk2 complexes by p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	171	R-HSA-187937	Reactome:R-HSA-187937	yes	reactome/R-HSA-187937.md	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	172	R-HSA-187948	Reactome:R-HSA-187948	yes	reactome/R-HSA-187948.md	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	173	R-HSA-187949	Reactome:R-HSA-187949	yes	reactome/R-HSA-187949.md	CAK-mediated phosphorylation of Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	174	R-HSA-187959	Reactome:R-HSA-187959	yes	reactome/R-HSA-187959.md	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	175	R-HSA-188350	Reactome:R-HSA-188350	yes	reactome/R-HSA-188350.md	CAK-mediated phosphorylation of Cyclin E:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	176	R-HSA-188371	Reactome:R-HSA-188371	yes	reactome/R-HSA-188371.md	Association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	177	R-HSA-188386	Reactome:R-HSA-188386	yes	reactome/R-HSA-188386.md	Association of Rb with Cyclin E:Cdk2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	178	R-HSA-188390	Reactome:R-HSA-188390	yes	reactome/R-HSA-188390.md	Cyclin E:CDK2-mediated phosphorylation of RB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	179	R-HSA-3788705	Reactome:R-HSA-3788705	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	180	R-HSA-3788708	Reactome:R-HSA-3788708	yes	reactome/R-HSA-3788708.md	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	181	R-HSA-4088024	Reactome:R-HSA-4088024	yes	reactome/R-HSA-4088024.md	CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	182	R-HSA-5684081	Reactome:R-HSA-5684081	yes	reactome/R-HSA-5684081.md	MRN complex binds CDK2 and RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	183	R-HSA-5684096	Reactome:R-HSA-5684096	yes	reactome/R-HSA-5684096.md	CDK2 phosphorylates RBBP8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	184	R-HSA-6793661	Reactome:R-HSA-6793661	yes	reactome/R-HSA-6793661.md	(CDK1,CDK2):CCNA phosphorylates MDM2 at T218	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	185	R-HSA-6805109	Reactome:R-HSA-6805109	yes	reactome/R-HSA-6805109.md	CDK2 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	186	R-HSA-68916	Reactome:R-HSA-68916	yes	reactome/R-HSA-68916.md	DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	187	R-HSA-68917	Reactome:R-HSA-68917	yes	reactome/R-HSA-68917.md	Cdc45 associates with the pre-replicative complex at the origin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	188	R-HSA-68918	Reactome:R-HSA-68918	yes	reactome/R-HSA-68918.md	CDK and DDK associate with the Mcm10:pre-replicative complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	189	R-HSA-68944	Reactome:R-HSA-68944	yes	reactome/R-HSA-68944.md	Orc1 is phosphorylated by cyclin A/CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	190	R-HSA-69005	Reactome:R-HSA-69005	yes	reactome/R-HSA-69005.md	Cdc6 protein is phosphorylated by CDK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	191	R-HSA-69195	Reactome:R-HSA-69195	yes	reactome/R-HSA-69195.md	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	192	R-HSA-69199	Reactome:R-HSA-69199	yes	reactome/R-HSA-69199.md	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	193	R-HSA-69562	Reactome:R-HSA-69562	yes	reactome/R-HSA-69562.md	Inactivation of Cyclin E:Cdk2 complexes by p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	194	R-HSA-9624120	Reactome:R-HSA-9624120	yes	reactome/R-HSA-9624120.md	CEBPA binds CDK2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK2	genes/human/CDK2/CDK2-ai-review.yaml	CDK2	P24941	NCBITaxon:9606	Homo sapiens	195	R-HSA-9686521	Reactome:R-HSA-9686521	yes	reactome/R-HSA-9686521.md	CDK2:CCNA phosphorylates TERF2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Localizes to the nucleoplasm, where cyclin-CDK2 acts on nuclear cell-cycle substrates (RB1, NPAT, etc.).
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	15	R-HSA-9008412	CDK4 phosphorylates RUNX2	yes	reactome/R-HSA-9008412.md	CDK4 phosphorylates RUNX2	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Cyclin-dependent protein serine/threonine kinase activity (EC 2.7.11.22) - CDK4's defining molecular function, active as the cyclin D-CDK4 holoenzyme.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	16	R-HSA-9929482	CDK4:CCND1 phosphorylates SPOP	yes	reactome/R-HSA-9929482.md	CDK4:CCND1 phosphorylates SPOP	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Cyclin-dependent protein serine/threonine kinase activity (EC 2.7.11.22) - CDK4's defining molecular function, active as the cyclin D-CDK4 holoenzyme.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	192	R-HSA-1226094	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	yes	reactome/R-HSA-1226094.md	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	193	R-HSA-1226095	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	yes	reactome/R-HSA-1226095.md	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	194	R-HSA-3215385	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	yes	reactome/R-HSA-3215385.md	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	195	R-HSA-3215426	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77	yes	reactome/R-HSA-3215426.md	COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	196	R-HSA-5205799	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)	yes	reactome/R-HSA-5205799.md	CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	197	R-HSA-5205861	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)	yes	reactome/R-HSA-5205861.md	COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	198	R-HSA-5216234	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)	yes	reactome/R-HSA-5216234.md	PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	199	R-HSA-5661117	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3	yes	reactome/R-HSA-5661117.md	CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	200	R-HSA-69227	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-69227.md	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	201	R-HSA-75822	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	yes	reactome/R-HSA-75822.md	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	202	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	203	R-HSA-8942836	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	yes	reactome/R-HSA-8942836.md	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	204	R-HSA-9008412	CDK4 phosphorylates RUNX2	yes	reactome/R-HSA-9008412.md	CDK4 phosphorylates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	205	R-HSA-9624112	CEBPA binds CDK4	yes	reactome/R-HSA-9624112.md	CEBPA binds CDK4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	206	R-HSA-9754130	CDK4 inhibitors bind CDK4	yes	reactome/R-HSA-9754130.md	CDK4 inhibitors bind CDK4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization where cyclin D-CDK4 acts on nuclear substrates.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	215	R-HSA-182594	Association of INK4 family proteins with CDK4/6	yes	reactome/R-HSA-182594.md	Association of INK4 family proteins with CDK4/6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	216	R-HSA-75822	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	yes	reactome/R-HSA-75822.md	Relocalization of nuclearly localized phospho-(T286):cyclin D1:Cdk4 to cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	217	R-HSA-8848414	Activated PTK6 binds CDKN1B	yes	reactome/R-HSA-8848414.md	Activated PTK6 binds CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	218	R-HSA-8848436	PTK6 phosphorylates CDKN1B	yes	reactome/R-HSA-8848436.md	PTK6 phosphorylates CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	219	R-HSA-8941895	Formation of CDK4/6:CCND complexes	yes	reactome/R-HSA-8941895.md	Formation of CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	220	R-HSA-8941915	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	yes	reactome/R-HSA-8941915.md	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	221	R-HSA-8942607	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	yes	reactome/R-HSA-8942607.md	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	222	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	223	R-HSA-9630792	p16INK4A mutants do not bind CDK4	yes	reactome/R-HSA-9630792.md	p16INK4A mutants do not bind CDK4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	224	R-HSA-9630795	p16INK4A mutants do not bind CDK4,CDK6	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	225	R-HSA-9929482	CDK4:CCND1 phosphorylates SPOP	yes	reactome/R-HSA-9929482.md	CDK4:CCND1 phosphorylates SPOP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of the resting/assembling CDK4 pool.
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	233	R-HSA-3215385	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	yes	reactome/R-HSA-3215385.md	CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77	Homo sapiens	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	TAS	enables	MF	false		MODIFY	Cyclin-dependent protein serine/threonine kinase regulator activity (TAS, Reactome).
human	CDK4	genes/human/CDK4/CDK4-ai-review.yaml	CDK4	P11802	NCBITaxon:9606	Homo sapiens	242	R-HSA-212436	Generic Transcription Pathway	yes	reactome/R-HSA-212436.md	Generic Transcription Pathway	Homo sapiens	GO:0060260	regulation of transcription initiation by RNA polymerase II	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Regulation of transcription initiation by RNA polymerase II (TAS, Reactome generic transcription pathway).
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	68	R-HSA-399944	Phosphorylation of CRMPs by Cdk5	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is a core CDK5 molecular function.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	69	R-HSA-8863007	p25-bound CDK5 phosphorylates CDC25B	yes	reactome/R-HSA-8863007.md	p25-bound CDK5 phosphorylates CDC25B	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is a core CDK5 molecular function.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	70	R-HSA-8863011	p25-bound CDK5 phosphorylates CDC25C	yes	reactome/R-HSA-8863011.md	p25-bound CDK5 phosphorylates CDC25C	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is a core CDK5 molecular function.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	71	R-HSA-8863014	p25-bound CDK5 phosphorylates CDC25A	yes	reactome/R-HSA-8863014.md	p25-bound CDK5 phosphorylates CDC25A	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is a core CDK5 molecular function.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	72	R-HSA-180047	CDK5 phosphorylates DARPP-32 on Thr75	yes	reactome/R-HSA-180047.md	CDK5 phosphorylates DARPP-32 on Thr75	Homo sapiens	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	cyclin-dependent protein serine/threonine kinase activity is a core CDK5 molecular function.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	101	R-HSA-8863014	p25-bound CDK5 phosphorylates CDC25A	yes	reactome/R-HSA-8863014.md	p25-bound CDK5 phosphorylates CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	102	R-HSA-8863587	CDK5:p25 translocates to the nucleus	yes	reactome/R-HSA-8863587.md	CDK5:p25 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	103	R-HSA-6805276	CDK5 phosphorylates TP53	yes	reactome/R-HSA-6805276.md	CDK5 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	107	R-HSA-399944	Phosphorylation of CRMPs by Cdk5	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	108	R-HSA-399951	Phosphorylation of CRMPs by GSK3beta	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	109	R-NUL-9032945	Ntrk2 phosohorylates CDK5	yes	reactome/R-NUL-9032945.md	Ntrk2 phosohorylates CDK5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	110	R-HSA-180047	CDK5 phosphorylates DARPP-32 on Thr75	yes	reactome/R-HSA-180047.md	CDK5 phosphorylates DARPP-32 on Thr75	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	111	R-HSA-8863007	p25-bound CDK5 phosphorylates CDC25B	yes	reactome/R-HSA-8863007.md	p25-bound CDK5 phosphorylates CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	112	R-HSA-8863011	p25-bound CDK5 phosphorylates CDC25C	yes	reactome/R-HSA-8863011.md	p25-bound CDK5 phosphorylates CDC25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	113	R-HSA-8863013	CDK5 binds p25	yes	reactome/R-HSA-8863013.md	CDK5 binds p25	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5	genes/human/CDK5/CDK5-ai-review.yaml	CDK5	Q00535	NCBITaxon:9606	Homo sapiens	114	R-HSA-8863587	CDK5:p25 translocates to the nucleus	yes	reactome/R-HSA-8863587.md	CDK5:p25 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is a broad or complex-context CDK5 localization.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	56	R-HSA-8863007	p25-bound CDK5 phosphorylates CDC25B	yes	reactome/R-HSA-8863007.md	p25-bound CDK5 phosphorylates CDC25B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Keep cytosol as secondary localization context for p35/p25 or transferred CDK5R-family biology.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	57	R-HSA-8863011	p25-bound CDK5 phosphorylates CDC25C	yes	reactome/R-HSA-8863011.md	p25-bound CDK5 phosphorylates CDC25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Keep cytosol as secondary localization context for p35/p25 or transferred CDK5R-family biology.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	58	R-HSA-8863013	CDK5 binds p25	yes	reactome/R-HSA-8863013.md	CDK5 binds p25	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Keep cytosol as secondary localization context for p35/p25 or transferred CDK5R-family biology.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	59	R-HSA-8863587	CDK5:p25 translocates to the nucleus	yes	reactome/R-HSA-8863587.md	CDK5:p25 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Keep cytosol as secondary localization context for p35/p25 or transferred CDK5R-family biology.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	60	R-HSA-6805276	CDK5 phosphorylates TP53	yes	reactome/R-HSA-6805276.md	CDK5 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accept nucleoplasm; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	61	R-HSA-8863014	p25-bound CDK5 phosphorylates CDC25A	yes	reactome/R-HSA-8863014.md	p25-bound CDK5 phosphorylates CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accept nucleoplasm; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	62	R-HSA-8863587	CDK5:p25 translocates to the nucleus	yes	reactome/R-HSA-8863587.md	CDK5:p25 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Accept nucleoplasm; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	63	R-HSA-399944	Phosphorylation of CRMPs by Cdk5	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accept plasma membrane; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	64	R-HSA-399951	Phosphorylation of CRMPs by GSK3beta	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accept plasma membrane; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK5R1	genes/human/CDK5R1/CDK5R1-ai-review.yaml	CDK5R1	Q15078	NCBITaxon:9606	Homo sapiens	65	R-HSA-9616110	EGR1-dependent CDK5R1 gene expression	yes	reactome/R-HSA-9616110.md	EGR1-dependent CDK5R1 gene expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accept plasma membrane; CDK5R1/p35-p25 localizes to neuronal projections, membrane/cytoplasmic regions, and p25-associated nuclear/perinuclear compartments.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	7	R-HSA-6810233	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	yes	reactome/R-HSA-6810233.md	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		MODIFY	Cyclin dependence is a conserved characteristic of CDK7.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	8	R-HSA-77071	Phosphorylation (Ser5) of RNA pol II CTD	yes	reactome/R-HSA-77071.md	Phosphorylation (Ser5) of RNA pol II CTD	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		MODIFY	Cyclin dependence is a conserved characteristic of CDK7.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	37	R-HSA-109639	Formation of the closed pre-initiation complex	yes	reactome/R-HSA-109639.md	Formation of the closed pre-initiation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	38	R-HSA-111264	Addition of nucleotides between position +11 and +30	yes	reactome/R-HSA-111264.md	Addition of nucleotides between position +11 and +30	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	39	R-HSA-112379	Recruitment of elongation factors to form elongation complex	yes	reactome/R-HSA-112379.md	Recruitment of elongation factors to form elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	40	R-HSA-112383	Hypophosphorylation of RNA Pol II CTD by FCP1P protein	yes	reactome/R-HSA-112383.md	Hypophosphorylation of RNA Pol II CTD by FCP1P protein	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	41	R-HSA-112385	Addition of nucleotides leads to transcript elongation	yes	reactome/R-HSA-112385.md	Addition of nucleotides leads to transcript elongation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	42	R-HSA-113430	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex	yes	reactome/R-HSA-113430.md	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	43	R-HSA-170076	CAK phosphorylates CDK1 bound to CCNB1	yes	reactome/R-HSA-170076.md	CAK phosphorylates CDK1 bound to CCNB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	44	R-HSA-170087	CAK phosphorylates CDK1 bound to CCNA	yes	reactome/R-HSA-170087.md	CAK phosphorylates CDK1 bound to CCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	45	R-HSA-187949	CAK-mediated phosphorylation of Cyclin A:Cdk2	yes	reactome/R-HSA-187949.md	CAK-mediated phosphorylation of Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	46	R-HSA-188350	CAK-mediated phosphorylation of Cyclin E:Cdk2	yes	reactome/R-HSA-188350.md	CAK-mediated phosphorylation of Cyclin E:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	47	R-HSA-5689861	Recruitment of XPA and release of CAK	yes	reactome/R-HSA-5689861.md	Recruitment of XPA and release of CAK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	48	R-HSA-5691000	TFIIH binds GG-NER site to form a verification complex	yes	reactome/R-HSA-5691000.md	TFIIH binds GG-NER site to form a verification complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	49	R-HSA-6781818	RNA Pol II initiates transcription from damaged DNA template	yes	reactome/R-HSA-6781818.md	RNA Pol II initiates transcription from damaged DNA template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	50	R-HSA-6781824	Active RNA Pol II complex transcribes lesion-containing DNA template	yes	reactome/R-HSA-6781824.md	Active RNA Pol II complex transcribes lesion-containing DNA template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	51	R-HSA-6781833	ERCC8 (CSA) binds stalled RNA Pol II	yes	reactome/R-HSA-6781833.md	ERCC8 (CSA) binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	52	R-HSA-6781840	ERCC6 binds stalled RNA Pol II	yes	reactome/R-HSA-6781840.md	ERCC6 binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	53	R-HSA-6781867	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	yes	reactome/R-HSA-6781867.md	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	54	R-HSA-6782004	Assembly of the pre-incision complex in TC-NER	yes	reactome/R-HSA-6782004.md	Assembly of the pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	55	R-HSA-6782069	UVSSA:USP7 deubiquitinates ERCC6	yes	reactome/R-HSA-6782069.md	UVSSA:USP7 deubiquitinates ERCC6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	56	R-HSA-6782131	ERCC2-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-6782131.md	ERCC2-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	57	R-HSA-6782138	ERCC5 and RPA bind TC-NER site	yes	reactome/R-HSA-6782138.md	ERCC5 and RPA bind TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	58	R-HSA-6782141	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	yes	reactome/R-HSA-6782141.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	59	R-HSA-6782204	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	yes	reactome/R-HSA-6782204.md	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	60	R-HSA-6782208	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	yes	reactome/R-HSA-6782208.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	61	R-HSA-6782211	DNA polymerases delta, epsilon or kappa bind the TC-NER site	yes	reactome/R-HSA-6782211.md	DNA polymerases delta, epsilon or kappa bind the TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	62	R-HSA-6782224	3' incision by ERCC5 (XPG) in TC-NER	yes	reactome/R-HSA-6782224.md	3' incision by ERCC5 (XPG) in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	63	R-HSA-6782227	Ligation of newly synthesized repair patch to incised DNA in TC-NER	yes	reactome/R-HSA-6782227.md	Ligation of newly synthesized repair patch to incised DNA in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	64	R-HSA-6782234	Recovery of RNA synthesis after TC-NER	yes	reactome/R-HSA-6782234.md	Recovery of RNA synthesis after TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	65	R-HSA-6797606	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	yes	reactome/R-HSA-6797606.md	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	66	R-HSA-6797616	CCNK:CDK12 binds RNA Pol II at DNA repair genes	yes	reactome/R-HSA-6797616.md	CCNK:CDK12 binds RNA Pol II at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	67	R-HSA-6810233	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	yes	reactome/R-HSA-6810233.md	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	68	R-HSA-6810234	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene	yes	reactome/R-HSA-6810234.md	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	69	R-HSA-6810235	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain	yes	reactome/R-HSA-6810235.md	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	70	R-HSA-6810238	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)	yes	reactome/R-HSA-6810238.md	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	71	R-HSA-6814549	Pre-snRNA transcript initiation, Integrator binding, LEC binding	yes	reactome/R-HSA-6814549.md	Pre-snRNA transcript initiation, Integrator binding, LEC binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	72	R-HSA-6814555	Integrator complex processes the 3' end of snRNA	yes	reactome/R-HSA-6814555.md	Integrator complex processes the 3' end of snRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	73	R-HSA-6814559	Pre-snRNA is elongated and capped with 7-methylguanosine	yes	reactome/R-HSA-6814559.md	Pre-snRNA is elongated and capped with 7-methylguanosine	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	74	R-HSA-6814885	CBCAP complex binds 7-methylguanosine cap of snRNA	yes	reactome/R-HSA-6814885.md	CBCAP complex binds 7-methylguanosine cap of snRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	75	R-HSA-73758	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter	yes	reactome/R-HSA-73758.md	Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	76	R-HSA-73769	Loss of Rrn3 from RNA Polymerase I promoter escape complex	yes	reactome/R-HSA-73769.md	Loss of Rrn3 from RNA Polymerase I promoter escape complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	77	R-HSA-73946	Abortive initiation after formation of the first phosphodiester bond	yes	reactome/R-HSA-73946.md	Abortive initiation after formation of the first phosphodiester bond	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	78	R-HSA-74986	Elongation of pre-rRNA transcript	yes	reactome/R-HSA-74986.md	Elongation of pre-rRNA transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	79	R-HSA-74992	Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box	yes	reactome/R-HSA-74992.md	Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	80	R-HSA-74993	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box	yes	reactome/R-HSA-74993.md	PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	81	R-HSA-74994	Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box	yes	reactome/R-HSA-74994.md	Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	82	R-HSA-75850	Addition of the third nucleotide on the nascent transcript	yes	reactome/R-HSA-75850.md	Addition of the third nucleotide on the nascent transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	83	R-HSA-75856	Abortive Initiation Before Second Transition	yes	reactome/R-HSA-75856.md	Abortive Initiation Before Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	84	R-HSA-75861	NTP Binds Active Site of RNA Polymerase II	yes	reactome/R-HSA-75861.md	NTP Binds Active Site of RNA Polymerase II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	85	R-HSA-75862	Fall Back to Closed Pre-initiation Complex	yes	reactome/R-HSA-75862.md	Fall Back to Closed Pre-initiation Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	86	R-HSA-75864	Newly Formed Phosphodiester Bond Stabilized and PPi Released	yes	reactome/R-HSA-75864.md	Newly Formed Phosphodiester Bond Stabilized and PPi Released	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	87	R-HSA-75866	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP	yes	reactome/R-HSA-75866.md	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	88	R-HSA-75869	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	yes	reactome/R-HSA-75869.md	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	89	R-HSA-75873	Addition of Nucleotides 5 through 9 on the growing Transcript	yes	reactome/R-HSA-75873.md	Addition of Nucleotides 5 through 9 on the growing Transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	90	R-HSA-75891	Abortive Initiation After Second Transition	yes	reactome/R-HSA-75891.md	Abortive Initiation After Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	91	R-HSA-75949	RNA Polymerase II Promoter Opening: First Transition	yes	reactome/R-HSA-75949.md	RNA Polymerase II Promoter Opening: First Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	92	R-HSA-76576	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition	yes	reactome/R-HSA-76576.md	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	93	R-HSA-77068	Activation of GT	yes	reactome/R-HSA-77068.md	Activation of GT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	94	R-HSA-77069	RNA Polymerase II CTD (phosphorylated) binds to CE	yes	reactome/R-HSA-77069.md	RNA Polymerase II CTD (phosphorylated) binds to CE	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	95	R-HSA-77071	Phosphorylation (Ser5) of RNA pol II CTD	yes	reactome/R-HSA-77071.md	Phosphorylation (Ser5) of RNA pol II CTD	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	96	R-HSA-77073	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)	yes	reactome/R-HSA-77073.md	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	97	R-HSA-77077	Capping complex formation	yes	reactome/R-HSA-77077.md	Capping complex formation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	98	R-HSA-77078	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme	yes	reactome/R-HSA-77078.md	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	99	R-HSA-77081	Formation of the CE:GMP intermediate complex	yes	reactome/R-HSA-77081.md	Formation of the CE:GMP intermediate complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	100	R-HSA-77083	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA	yes	reactome/R-HSA-77083.md	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	101	R-HSA-77085	Dissociation of transcript with 5'-GMP from GT	yes	reactome/R-HSA-77085.md	Dissociation of transcript with 5'-GMP from GT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	102	R-HSA-77090	Methylation of GMP-cap by RNA Methyltransferase	yes	reactome/R-HSA-77090.md	Methylation of GMP-cap by RNA Methyltransferase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	103	R-HSA-8942836	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	yes	reactome/R-HSA-8942836.md	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	104	R-HSA-9613494	Unwinding of DNA for the Nascent Transcript: Second Transition	yes	reactome/R-HSA-9613494.md	Unwinding of DNA for the Nascent Transcript: Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	105	R-HSA-9613497	Unwinding DNA for the nascent transcript	yes	reactome/R-HSA-9613497.md	Unwinding DNA for the nascent transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	106	R-HSA-9684118	ERCC3-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-9684118.md	ERCC3-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	115	R-HSA-73857	RNA Polymerase II Transcription	yes	reactome/R-HSA-73857.md	RNA Polymerase II Transcription	Homo sapiens	GO:0006366	transcription by RNA polymerase II	TAS	involved_in	BP	false		ACCEPT	Phosphorylation of RNA polymerase II CTD is a central contribution to transcription.
human	CDK7	genes/human/CDK7/CDK7-ai-review.yaml	CDK7	P50613	NCBITaxon:9606	Homo sapiens	130	R-HSA-6807505	RNA polymerase II transcribes snRNA genes	yes	reactome/R-HSA-6807505.md	RNA polymerase II transcribes snRNA genes	Homo sapiens	GO:0042795	snRNA transcription by RNA polymerase II	TAS	involved_in	BP	false		ACCEPT	CDK7 supports RNA polymerase II transcription, including the polymerase-II-transcribed small nuclear RNA program represented by the pathway annotation.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	3	R-HSA-69206	G1/S Transition	yes	reactome/R-HSA-69206.md	G1/S Transition	Homo sapiens	GO:0000082	G1/S transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	G1/S transition, asserted by the Reactome G1/S Transition pathway in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	12	R-HSA-187934	Inactivation of Cyclin A:Cdk2 complexes by p27/p21	yes	reactome/R-HSA-187934.md	Inactivation of Cyclin A:Cdk2 complexes by p27/p21	Homo sapiens	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	TAS	enables	MF	false		ACCEPT	CDK inhibitor activity asserted by the Reactome reaction 'Inactivation of Cyclin A:Cdk2 complexes by p27/p21'.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	13	R-HSA-69562	Inactivation of Cyclin E:Cdk2 complexes by p27/p21	yes	reactome/R-HSA-69562.md	Inactivation of Cyclin E:Cdk2 complexes by p27/p21	Homo sapiens	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	TAS	enables	MF	false		ACCEPT	CDK inhibitor activity asserted by the Reactome reaction 'Inactivation of Cyclin E:Cdk2 complexes by p27/p21'.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	145	R-HSA-1226094	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	yes	reactome/R-HSA-1226094.md	Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	146	R-HSA-1226095	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	yes	reactome/R-HSA-1226095.md	Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	147	R-HSA-187506	Translocation of p27 to the nucleoplasm	yes	reactome/R-HSA-187506.md	Translocation of p27 to the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Translocation of p27 to the nucleoplasm', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	148	R-HSA-187520	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	yes	reactome/R-HSA-187520.md	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	149	R-HSA-187552	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	150	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Degradation of ubiquitinated p27/p21 by the 26S proteasome', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	151	R-HSA-187575	Ubiquitination of phospho-p27/p21	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Ubiquitination of phospho-p27/p21', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	152	R-HSA-187916	Cyclin A:Cdk2 mediated phosphorylation of p27/p21	yes	reactome/R-HSA-187916.md	Cyclin A:Cdk2 mediated phosphorylation of p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Cyclin A:Cdk2 mediated phosphorylation of p27/p21', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	153	R-HSA-187934	Inactivation of Cyclin A:Cdk2 complexes by p27/p21	yes	reactome/R-HSA-187934.md	Inactivation of Cyclin A:Cdk2 complexes by p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Inactivation of Cyclin A:Cdk2 complexes by p27/p21', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	154	R-HSA-69227	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-69227.md	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	155	R-HSA-69562	Inactivation of Cyclin E:Cdk2 complexes by p27/p21	yes	reactome/R-HSA-69562.md	Inactivation of Cyclin E:Cdk2 complexes by p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Inactivation of Cyclin E:Cdk2 complexes by p27/p21', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	156	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	157	R-HSA-8942836	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	yes	reactome/R-HSA-8942836.md	CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	158	R-HSA-9632868	CDKN1B is phosphorylated in response to estrogen	yes	reactome/R-HSA-9632868.md	CDKN1B is phosphorylated in response to estrogen	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'CDKN1B is phosphorylated in response to estrogen', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	159	R-HSA-9632873	p-S10 CDKN1B translocates to the cytosol	yes	reactome/R-HSA-9632873.md	p-S10 CDKN1B translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localisation asserted by the Reactome reaction 'p-S10 CDKN1B translocates to the cytosol', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	166	R-HSA-187506	Translocation of p27 to the nucleoplasm	yes	reactome/R-HSA-187506.md	Translocation of p27 to the nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Translocation of p27 to the nucleoplasm', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	167	R-HSA-198613	AKT phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-198613.md	AKT phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'AKT phosphorylates p21Cip1 and p27Kip1', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	168	R-HSA-2399969	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	yes	reactome/R-HSA-2399969.md	AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	169	R-HSA-8848414	Activated PTK6 binds CDKN1B	yes	reactome/R-HSA-8848414.md	Activated PTK6 binds CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Activated PTK6 binds CDKN1B', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	170	R-HSA-8848436	PTK6 phosphorylates CDKN1B	yes	reactome/R-HSA-8848436.md	PTK6 phosphorylates CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'PTK6 phosphorylates CDKN1B', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	171	R-HSA-8941915	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	yes	reactome/R-HSA-8941915.md	Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	172	R-HSA-8942607	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	yes	reactome/R-HSA-8942607.md	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	173	R-HSA-8942803	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	yes	reactome/R-HSA-8942803.md	Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	174	R-HSA-9632873	p-S10 CDKN1B translocates to the cytosol	yes	reactome/R-HSA-9632873.md	p-S10 CDKN1B translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'p-S10 CDKN1B translocates to the cytosol', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	175	R-HSA-9699575	FOXO3-dependent CDKN1B gene expression	yes	reactome/R-HSA-9699575.md	FOXO3-dependent CDKN1B gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'FOXO3-dependent CDKN1B gene expression', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	176	R-HSA-9699578	Active FLT3 phosphorylates CDKN1B	yes	reactome/R-HSA-9699578.md	Active FLT3 phosphorylates CDKN1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localisation asserted by the Reactome reaction 'Active FLT3 phosphorylates CDKN1B', in which CDKN1B is a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	186	R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes	yes	reactome/R-HSA-6791312.md	TP53 Regulates Transcription of Cell Cycle Genes	Homo sapiens	GO:0030330	DNA damage response, signal transduction by p53 class mediator	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	DNA damage response, signal transduction by p53 class mediator, asserted via the Reactome pathway 'TP53 Regulates Transcription of Cell Cycle Genes', in which CDKN1B appears as a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	187	R-HSA-69563	p53-Dependent G1 DNA Damage Response	yes	reactome/R-HSA-69563.md	p53-Dependent G1 DNA Damage Response	Homo sapiens	GO:0030330	DNA damage response, signal transduction by p53 class mediator	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	DNA damage response, signal transduction by p53 class mediator, asserted via the Reactome pathway 'p53-Dependent G1 DNA Damage Response', in which CDKN1B appears as a participant.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	196	R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	yes	reactome/R-HSA-69656.md	Cyclin A:Cdk2-associated events at S phase entry	Homo sapiens	GO:0045740	positive regulation of DNA replication	TAS	involved_in	BP	false		MODIFY	Positive regulation of DNA replication, asserted via the Reactome pathway 'Cyclin A:Cdk2-associated events at S phase entry', in which CDKN1B participates.
human	CDKN1B	genes/human/CDKN1B/CDKN1B-ai-review.yaml	CDKN1B	P46527	NCBITaxon:9606	Homo sapiens	205	R-HSA-2559583	Cellular Senescence	yes	reactome/R-HSA-2559583.md	Cellular Senescence	Homo sapiens	GO:0090398	cellular senescence	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Cellular senescence, asserted via Reactome's Cellular Senescence pathway.
human	CDO1	genes/human/CDO1/CDO1-ai-review.yaml	CDO1	Q16878	NCBITaxon:9606	Homo sapiens	28	R-HSA-1614645	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine	yes	reactome/R-HSA-1614645.md	CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Author-statement (TAS, Reactome) annotation placing the CDO1-catalyzed reaction in the cytosol. Consistent with the soluble cytosolic localization of CDO1; correct core location.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	44	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Mad1 binds kinetochore', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	45	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'MAD2 converted to an inhibitory state', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	46	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'MAD2 associates with the Mad1 kinetochore complex', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	47	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Release of activated MAD2 from kinetochores', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	48	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Phosphorylation of cohesin by PLK1 at centromeres', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	49	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'PP2A-B56 dephosphorylates centromeric cohesin', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	50	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'ESPL1 cleaves centromeric cohesin', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	51	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Separation of sister chromatids', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	52	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'CDK1 phosphorylates CDCA5 at centromeres', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	53	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Kinetochore assembly', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	54	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Kinetochore capture of astral microtubules', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	55	R-HSA-4088441	FOXM1 stimulates CENPF transcription	yes	reactome/R-HSA-4088441.md	FOXM1 stimulates CENPF transcription	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'FOXM1 stimulates CENPF transcription', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	56	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'CDC42:GTP recruits DIAPH2-2 to kinetochores', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	57	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'AURKB phosphorylates DIAPH2-2 at kinetochores', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	58	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'Kinetochore capture of astral microtubules regulated by CDC42/DIAPH2', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CENPF	genes/human/CENPF/CENPF-ai-review.yaml	CENPF	P49454	NCBITaxon:9606	Homo sapiens	59	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol, from the reaction 'EML4 recruits NUDC to mitotic spindle', in which CENPF participates as a kinetochore/centromere component represented in the cytosolic compartment after nuclear envelope breakdown.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	24	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	25	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	26	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	27	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	28	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	29	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	30	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	31	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	32	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	33	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	34	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	35	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	36	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	37	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	38	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	39	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	40	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	41	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	42	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	43	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	44	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEP152	genes/human/CEP152/CEP152-ai-review.yaml	CEP152	O94986	NCBITaxon:9606	Homo sapiens	45	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places CEP152 in a soluble cytosolic pool for this event; the location is plausible but broad and is not an independent localization experiment.
human	CEPT1	genes/human/CEPT1/CEPT1-ai-review.yaml	CEPT1	Q9Y6K0	NCBITaxon:9606	Homo sapiens	27	R-HSA-1482961	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane	yes	reactome/R-HSA-1482961.md	CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization. Reactome places the CEPT1-catalyzed conversion of CDP-choline and DAG to PC at the ER membrane.
human	CEPT1	genes/human/CEPT1/CEPT1-ai-review.yaml	CEPT1	Q9Y6K0	NCBITaxon:9606	Homo sapiens	28	R-HSA-1482962	CDP-ETA and DAG are converted to PE by CEPT1/EPT1	yes	reactome/R-HSA-1482962.md	CDP-ETA and DAG are converted to PE by CEPT1/EPT1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization. Reactome places the CEPT1/EPT1-catalyzed conversion of CDP-ethanolamine and DAG to PE at the ER membrane.
human	CERS1	genes/human/CERS1/CERS1-ai-review.yaml	CERS1	P27544	NCBITaxon:9606	Homo sapiens	12	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (Sphingolipid de novo biosynthesis) traceable assignment of CERS1 to sphingolipid biosynthesis, the pathway parent of ceramide biosynthesis.
human	CERS1	genes/human/CERS1/CERS1-ai-review.yaml	CERS1	P27544	NCBITaxon:9606	Homo sapiens	16	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0050291	sphingosine N-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (Ceramide synthases transfer acyl-CoA onto sphingoid) traceable assignment of the core ceramide-synthase catalytic activity.
human	CERS1	genes/human/CERS1/CERS1-ai-review.yaml	CERS1	P27544	NCBITaxon:9606	Homo sapiens	38	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (Ceramide synthases transfer acyl-CoA onto sphingoid) traceable assignment of CERS1 to the ER membrane.
human	CERS2	genes/human/CERS2/CERS2-ai-review.yaml	CERS2	Q96G23	NCBITaxon:9606	Homo sapiens	20	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation placing CERS2 in sphingolipid de novo biosynthesis, the pathway superset of ceramide biosynthesis.
human	CERS2	genes/human/CERS2/CERS2-ai-review.yaml	CERS2	Q96G23	NCBITaxon:9606	Homo sapiens	22	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0050291	sphingosine N-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of sphingosine N-acyltransferase (ceramide synthase) activity, the core MF.
human	CERS2	genes/human/CERS2/CERS2-ai-review.yaml	CERS2	Q96G23	NCBITaxon:9606	Homo sapiens	42	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation of ER membrane localization.
human	CERS3	genes/human/CERS3/CERS3-ai-review.yaml	CERS3	Q8IU89	NCBITaxon:9606	Homo sapiens	17	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of CERS3 in sphingolipid de novo biosynthesis. Correct but broader than the specific ceramide biosynthetic process.
human	CERS3	genes/human/CERS3/CERS3-ai-review.yaml	CERS3	Q8IU89	NCBITaxon:9606	Homo sapiens	19	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0050291	sphingosine N-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core ceramide synthase / sphingosine N-acyltransferase activity, redundant with the experimental and IBA annotations.
human	CERS3	genes/human/CERS3/CERS3-ai-review.yaml	CERS3	Q8IU89	NCBITaxon:9606	Homo sapiens	32	R-HSA-428185	Ceramide synthases transfer acyl-CoA onto sphingoid	yes	reactome/R-HSA-428185.md	Ceramide synthases transfer acyl-CoA onto sphingoid	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to ER membrane, the precise and correct subcellular location of CERS3 and site of its catalytic activity.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	83	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		ACCEPT	This TAS annotation from Reactome correctly identifies CFTR's role in transmembrane transport.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	102	R-HSA-383190	HCO3- transport through ion channel	yes	reactome/R-HSA-383190.md	HCO3- transport through ion channel	Homo sapiens	GO:0017081	chloride channel regulator activity	TAS	enables	MF	false		ACCEPT	This TAS annotation from Reactome suggests CFTR has chloride channel regulator activity, which is accurate as CFTR regulates other chloride channels like ORCC and ClC channels.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	105	R-HSA-5678822	Defective CFTR does not transport Cl- from cytosol to extracellular region	yes	reactome/R-HSA-5678822.md	Defective CFTR does not transport Cl- from cytosol to extracellular region	Homo sapiens	GO:0015108	chloride transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	This TAS annotation from Reactome correctly identifies CFTR's chloride transport function.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	106	R-HSA-5678863	CFTR transports Cl- from cytosol to extracellular region	yes	reactome/R-HSA-5678863.md	CFTR transports Cl- from cytosol to extracellular region	Homo sapiens	GO:0015108	chloride transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	This TAS annotation from Reactome correctly identifies CFTR's chloride transport function.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	107	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0043225	obsolete ATPase-coupled inorganic anion transmembrane transporter activity	TAS	enables	MF	false		REMOVE	This annotation uses an obsolete GO term and should be replaced with current terminology.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	108	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This TAS annotation from Reactome identifies CFTR in clathrin-coated endocytic vesicle membranes during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	109	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This TAS annotation from Reactome identifies CFTR in clathrin-coated endocytic vesicle membranes.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	110	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This TAS annotation from Reactome identifies CFTR in clathrin-coated endocytic vesicle membranes.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	111	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CFTR in clathrin-coated endocytic vesicle membranes during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	112	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CFTR in clathrin-coated endocytic vesicle membranes during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	113	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CFTR in clathrin-coated endocytic vesicle membranes during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	114	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CFTR in clathrin-coated endocytic vesicle membranes during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	142	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	CFTR transiently localizes to the ER membrane during biosynthesis before trafficking to the plasma membrane. This Reactome annotation documents CFTR's presence in the ER secretory pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	143	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	144	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	145	R-HSA-8866553	misfolded CFTR is degraded by the 26S proteasome	yes	reactome/R-HSA-8866553.md	misfolded CFTR is degraded by the 26S proteasome	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	146	R-HSA-8866851	CFTR transits to the plasma membrane	yes	reactome/R-HSA-8866851.md	CFTR transits to the plasma membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	147	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	148	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	149	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	150	R-HSA-9641109	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1	yes	reactome/R-HSA-9641109.md	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	151	R-HSA-9641111	Parkin transfers Ub to misfolded proteins	yes	reactome/R-HSA-9641111.md	Parkin transfers Ub to misfolded proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	152	R-HSA-9641127	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins	yes	reactome/R-HSA-9641127.md	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	153	R-HSA-9646348	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	yes	reactome/R-HSA-9646348.md	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	154	R-HSA-9646679	PolyUb-Misfolded proteins bind vimentin to form aggresome	yes	reactome/R-HSA-9646679.md	PolyUb-Misfolded proteins bind vimentin to form aggresome	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	155	R-HSA-9646685	Aggresome dissociates from dynein and microtubule	yes	reactome/R-HSA-9646685.md	Aggresome dissociates from dynein and microtubule	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	156	R-HSA-9700266	CFTR F508del binds CFTR correctors	yes	reactome/R-HSA-9700266.md	CFTR F508del binds CFTR correctors	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in ER membrane during biosynthesis pathway.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	157	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation indicating CFTR cytosolic domains face the cytosol. The NBD1, NBD2, and R domains of CFTR are cytoplasmic.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	158	R-HSA-8866858	CFTR F508del is degraded by the 26S proteasome	yes	reactome/R-HSA-8866858.md	CFTR F508del is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation indicating CFTR cytosolic domains face the cytosol.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	159	R-HSA-8866277	AP-2 directly binds some endocytic cargo	yes	reactome/R-HSA-8866277.md	AP-2 directly binds some endocytic cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization. CFTR functions as a chloride channel at the plasma membrane of epithelial cells.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	160	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	161	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	162	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	163	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	164	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	165	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	166	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	167	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	168	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	169	R-HSA-6782106	USP10 deubiquitinates SNX3, CFTR	yes	reactome/R-HSA-6782106.md	USP10 deubiquitinates SNX3, CFTR	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in endosome membrane during endocytic recycling. CFTR is rapidly endocytosed and recycled back to the plasma membrane.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	173	R-HSA-5678822	Defective CFTR does not transport Cl- from cytosol to extracellular region	yes	reactome/R-HSA-5678822.md	Defective CFTR does not transport Cl- from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	174	R-HSA-5678992	Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region	yes	reactome/R-HSA-5678992.md	Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	175	R-HSA-5679000	Ivacaftor binds CFTR G551D	yes	reactome/R-HSA-5679000.md	Ivacaftor binds CFTR G551D	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	176	R-HSA-5627275	GOPC promotes translocation of CFTR to lysosomes	yes	reactome/R-HSA-5627275.md	GOPC promotes translocation of CFTR to lysosomes	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in lysosomal membrane. Ubiquitinated CFTR that is not recycled is degraded in lysosomes.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	180	R-HSA-5627071	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane	yes	reactome/R-HSA-5627071.md	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane	Homo sapiens	GO:0030660	Golgi-associated vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in Golgi-associated vesicles during trafficking to the plasma membrane.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	181	R-HSA-5627072	RHOQ binds GOPC:CFTR	yes	reactome/R-HSA-5627072.md	RHOQ binds GOPC:CFTR	Homo sapiens	GO:0030660	Golgi-associated vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in Golgi-associated vesicles during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	182	R-HSA-5627275	GOPC promotes translocation of CFTR to lysosomes	yes	reactome/R-HSA-5627275.md	GOPC promotes translocation of CFTR to lysosomes	Homo sapiens	GO:0030660	Golgi-associated vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CFTR in Golgi-associated vesicles during trafficking.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	191	R-HSA-1454916	The ABCC family mediates organic anion transport	yes	reactome/R-HSA-1454916.md	The ABCC family mediates organic anion transport	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	192	R-HSA-383190	HCO3- transport through ion channel	yes	reactome/R-HSA-383190.md	HCO3- transport through ion channel	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	193	R-HSA-5627071	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane	yes	reactome/R-HSA-5627071.md	RHOQ positively regulates trafficking of GOPC:CFTR to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	194	R-HSA-5678863	CFTR transports Cl- from cytosol to extracellular region	yes	reactome/R-HSA-5678863.md	CFTR transports Cl- from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CFTR	genes/human/CFTR/CFTR-ai-review.yaml	CFTR	P13569	NCBITaxon:9606	Homo sapiens	195	R-HSA-8866851	CFTR transits to the plasma membrane	yes	reactome/R-HSA-8866851.md	CFTR transits to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CFTR plasma membrane localization.
human	CH25H	genes/human/CH25H/CH25H-ai-review.yaml	CH25H	O95992	NCBITaxon:9606	Homo sapiens	22	R-HSA-191983	Cholesterol is hydroxylated to 25-hydroxycholesterol	yes	reactome/R-HSA-191983.md	Cholesterol is hydroxylated to 25-hydroxycholesterol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Mislocalization. This TAS annotation reflects the compartment assigned to a Reactome reaction (""Cholesterol is hydroxylated to 25-hydroxycholesterol""), not the true topology of the enzyme. CH25H is a multi-pass integral ER-membrane protein (three transmembrane helices); it is not a cytosolic protein. The ER membrane annotations are the accurate ones."
human	CHAC1	genes/human/CHAC1/CHAC1-ai-review.yaml	CHAC1	Q9BUX1	NCBITaxon:9606	Homo sapiens	12	R-HSA-174403	Glutathione synthesis and recycling	yes	reactome/R-HSA-174403.md	Glutathione synthesis and recycling	Homo sapiens	GO:0006749	glutathione metabolic process	TAS	involved_in	BP	false		MODIFY	Reactome TAS placing CHAC1 in glutathione metabolism. Correct but a broad parent of the more specific catabolic process (GO:0006751) that CHAC1 actually performs. Retained as a true, if general, process annotation.
human	CHAC1	genes/human/CHAC1/CHAC1-ai-review.yaml	CHAC1	Q9BUX1	NCBITaxon:9606	Homo sapiens	14	R-HSA-6785928	CHAC1,2 cleaves GSH to OPRO and CysGly	yes	reactome/R-HSA-6785928.md	CHAC1,2 cleaves GSH to OPRO and CysGly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation for the CHAC1/2 GSH-cleavage reaction. Consistent with the experimental IDA; correct core location.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	14	R-HSA-5685230	CHEK1 phosphorylates RAD51	yes	reactome/R-HSA-5685230.md	CHEK1 phosphorylates RAD51	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	15	R-HSA-5685242	CHEK1 phosphorylates BRCA2	yes	reactome/R-HSA-5685242.md	CHEK1 phosphorylates BRCA2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799246	CHEK1 phosphorylates TP53	yes	reactome/R-HSA-6799246.md	CHEK1 phosphorylates TP53	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	17	R-HSA-69604	Phosphorylation of CDC25A by CHEK1	yes	reactome/R-HSA-69604.md	Phosphorylation of CDC25A by CHEK1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	18	R-HSA-75010	Phosphorylation of Cdc25C at Ser 216 by Chk1	yes	reactome/R-HSA-75010.md	Phosphorylation of Cdc25C at Ser 216 by Chk1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	19	R-HSA-9007539	CHEK1 phosphorylates E2F6	yes	reactome/R-HSA-9007539.md	CHEK1 phosphorylates E2F6	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	20	R-HSA-9943662	CHEK1 phosphorylates NEK11	yes	reactome/R-HSA-9943662.md	CHEK1 phosphorylates NEK11	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	21	R-HSA-9943678	CHEK1 phosphorylates CHEK2-phosphorylated CDC25A	yes	reactome/R-HSA-9943678.md	CHEK1 phosphorylates CHEK2-phosphorylated CDC25A	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity (Reactome TAS) for CHK1 checkpoint phosphorylation events.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	57	R-HSA-176116	Recruitment and activation of Chk1	yes	reactome/R-HSA-176116.md	Recruitment and activation of Chk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	58	R-HSA-5684882	CHEK1 is recruited to resected DNA DSBs	yes	reactome/R-HSA-5684882.md	CHEK1 is recruited to resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	59	R-HSA-5684887	Activation of CHEK1 at resected DNA DSBs	yes	reactome/R-HSA-5684887.md	Activation of CHEK1 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	60	R-HSA-5685230	CHEK1 phosphorylates RAD51	yes	reactome/R-HSA-5685230.md	CHEK1 phosphorylates RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	61	R-HSA-5685242	CHEK1 phosphorylates BRCA2	yes	reactome/R-HSA-5685242.md	CHEK1 phosphorylates BRCA2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	62	R-HSA-6799246	CHEK1 phosphorylates TP53	yes	reactome/R-HSA-6799246.md	CHEK1 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	63	R-HSA-69604	Phosphorylation of CDC25A by CHEK1	yes	reactome/R-HSA-69604.md	Phosphorylation of CDC25A by CHEK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	64	R-HSA-75010	Phosphorylation of Cdc25C at Ser 216 by Chk1	yes	reactome/R-HSA-75010.md	Phosphorylation of Cdc25C at Ser 216 by Chk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	65	R-HSA-9007539	CHEK1 phosphorylates E2F6	yes	reactome/R-HSA-9007539.md	CHEK1 phosphorylates E2F6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	66	R-HSA-9943662	CHEK1 phosphorylates NEK11	yes	reactome/R-HSA-9943662.md	CHEK1 phosphorylates NEK11	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	67	R-HSA-9943678	CHEK1 phosphorylates CHEK2-phosphorylated CDC25A	yes	reactome/R-HSA-9943678.md	CHEK1 phosphorylates CHEK2-phosphorylated CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (IDA/Reactome TAS).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	78	R-HSA-205328	Interaction of other tyrosine kinases with p-KIT	yes	reactome/R-HSA-205328.md	Interaction of other tyrosine kinases with p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Cytosol localization derived from Reactome R-HSA-205328.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	79	R-HSA-176187	Activation of ATR in response to replication stress	yes	reactome/R-HSA-176187.md	Activation of ATR in response to replication stress	Homo sapiens	GO:0006260	DNA replication	TAS	involved_in	BP	false		MODIFY	CHK1 restrains DNA replication (origin firing, fork progression) but does not perform replication.
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	102	R-HSA-8953750	Transcriptional Regulation by E2F6	yes	reactome/R-HSA-8953750.md	Transcriptional Regulation by E2F6	Homo sapiens	GO:0070317	negative regulation of G0 to G1 transition	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Negative regulation of G0-to-G1 transition (Reactome, via E2F6 phosphorylation).
human	CHEK1	genes/human/CHEK1/CHEK1-ai-review.yaml	CHEK1	O14757	NCBITaxon:9606	Homo sapiens	119	R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	yes	reactome/R-HSA-6804756.md	Regulation of TP53 Activity through Phosphorylation	Homo sapiens	GO:1901796	regulation of signal transduction by p53 class mediator	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Regulation of p53-class signaling (Reactome TAS) via CHK1 phosphorylation of TP53.
human	CHKA	genes/human/CHKA/CHKA-ai-review.yaml	CHKA	P35790	NCBITaxon:9606	Homo sapiens	24	R-HSA-1483004	Cho is phosphorylated to PCho by CHK dimer	yes	reactome/R-HSA-1483004.md	Cho is phosphorylated to PCho by CHK dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the CHK dimer in the cytosol for the choline-to-phosphocholine reaction. Consistent with the core cytosolic localization.
human	CHKA	genes/human/CHKA/CHKA-ai-review.yaml	CHKA	P35790	NCBITaxon:9606	Homo sapiens	25	R-HSA-1483222	ETA is phosphorylated to PETA by CHK/ETNK	yes	reactome/R-HSA-1483222.md	ETA is phosphorylated to PETA by CHK/ETNK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the CHK dimer in the cytosol for the ethanolamine-to-phosphoethanolamine reaction. Consistent with the core cytosolic localization.
human	CHKB	genes/human/CHKB/CHKB-ai-review.yaml	CHKB	Q9Y259	NCBITaxon:9606	Homo sapiens	10	R-HSA-1483004	Cho is phosphorylated to PCho by CHK dimer	yes	reactome/R-HSA-1483004.md	Cho is phosphorylated to PCho by CHK dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome, choline phosphorylation reaction). CHKB is a soluble enzyme and the choline kinase reaction occurs in the cytosol; this is the core location.
human	CHKB	genes/human/CHKB/CHKB-ai-review.yaml	CHKB	Q9Y259	NCBITaxon:9606	Homo sapiens	11	R-HSA-1483222	ETA is phosphorylated to PETA by CHK/ETNK	yes	reactome/R-HSA-1483222.md	ETA is phosphorylated to PETA by CHK/ETNK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome, ethanolamine phosphorylation reaction). Duplicate of the cytosol annotation from a second Reactome reaction; correct and core.
human	CHMP1A	genes/human/CHMP1A/CHMP1A-ai-review.yaml	CHMP1A	Q9HD42	NCBITaxon:9606	Homo sapiens	71	R-HSA-9610942	HCMV Formation of Final Envelopment Complex	yes	reactome/R-HSA-9610942.md	HCMV Formation of Final Envelopment Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HCMV final envelopment complex formation.
human	CHMP1A	genes/human/CHMP1A/CHMP1A-ai-review.yaml	CHMP1A	Q9HD42	NCBITaxon:9606	Homo sapiens	72	R-HSA-9610954	HCMV Final Envelopment	yes	reactome/R-HSA-9610954.md	HCMV Final Envelopment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HCMV final envelopment.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	61	R-HSA-917700	Reactome pathway annotation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A is cytosolic in autoinhibited state before membrane recruitment.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	62	R-HSA-3159232	Reactome pathway - ESCRT-mediated membrane scission	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization in ESCRT pathway.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	63	R-HSA-5671702	Reactome pathway - ESCRT-III recruitment to midbody	yes	reactome/R-HSA-5671702.md	AP1G2 binds HGS and CHMP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	64	R-HSA-917693	Reactome pathway - Autophagic flux	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	65	R-HSA-9668389	Reactome pathway - Nuclear envelope sealing	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	66	R-HSA-9668395	Reactome pathway - ESCRT complex assembly	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	67	R-HSA-9668398	Reactome pathway - Membrane scission	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	68	R-HSA-9668405	Reactome pathway - MVB formation	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	69	R-HSA-9668415	Reactome pathway - Viral budding	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2A	genes/human/CHMP2A/CHMP2A-ai-review.yaml	CHMP2A	O43633	NCBITaxon:9606	Homo sapiens	70	R-HSA-9668419	Reactome pathway - Plasma membrane repair	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHMP2A cytosolic localization.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	89	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HIV virion budding machinery.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	90	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ESCRT disassembly.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	91	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MVB vesicle formation.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	92	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for NE fenestration.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	93	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CHMP7-CC2D1B binding.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	94	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CHMP7-CHMP4B binding and ESCRT-III recruitment.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	95	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for spastin binding to IST1.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	96	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for VPS4-mediated ESCRT-III disassembly.
human	CHMP2B	genes/human/CHMP2B/CHMP2B-ai-review.yaml	CHMP2B	Q9UQN3	NCBITaxon:9606	Homo sapiens	97	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for spastin-mediated microtubule severing.
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	98	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization (HIV virion budding).
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	99	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization (ESCRT disassembly).
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	100	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization (MVB vesicle formation).
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	101	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization (NE reformation).
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	102	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	103	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	104	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	105	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	CHMP3	genes/human/CHMP3/CHMP3-ai-review.yaml	CHMP3	Q9Y3E7	NCBITaxon:9606	Homo sapiens	106	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	94	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	95	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	96	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	97	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	98	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	99	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	100	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	101	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4A	genes/human/CHMP4A/CHMP4A-ai-review.yaml	CHMP4A	Q9BY43	NCBITaxon:9606	Homo sapiens	102	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible non-core CHMP4A ESCRT context: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	126	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	127	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	128	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	129	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	130	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	131	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	132	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	133	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4B	genes/human/CHMP4B/CHMP4B-ai-review.yaml	CHMP4B	Q9H444	NCBITaxon:9606	Homo sapiens	134	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4B location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	80	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	81	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	82	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	83	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	84	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	85	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	86	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	87	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP4C	genes/human/CHMP4C/CHMP4C-ai-review.yaml	CHMP4C	Q96CF2	NCBITaxon:9606	Homo sapiens	88	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP4C location: cytosol.
human	CHMP5	genes/human/CHMP5/CHMP5-ai-review.yaml	CHMP5	Q9NZZ3	NCBITaxon:9606	Homo sapiens	83	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP5 location: cytosol.
human	CHMP5	genes/human/CHMP5/CHMP5-ai-review.yaml	CHMP5	Q9NZZ3	NCBITaxon:9606	Homo sapiens	84	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP5 location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	76	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	77	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	78	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	79	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	80	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	81	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	82	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	83	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP6	genes/human/CHMP6/CHMP6-ai-review.yaml	CHMP6	Q96FZ7	NCBITaxon:9606	Homo sapiens	84	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	True or plausible broad CHMP6 soluble pool/location: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	73	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	74	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	75	R-HSA-917700	MVB Vesicle Formation	yes	reactome/R-HSA-917700.md	MVB Vesicle Formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	76	R-HSA-9668335	CHMP7 binds LEMD2	yes	reactome/R-HSA-9668335.md	CHMP7 binds LEMD2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	77	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	78	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	79	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	80	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	81	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHMP7	genes/human/CHMP7/CHMP7-ai-review.yaml	CHMP7	Q8WUX9	NCBITaxon:9606	Homo sapiens	82	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible secondary ESCRT pathway or broad location context for CHMP7: cytosol.
human	CHPT1	genes/human/CHPT1/CHPT1-ai-review.yaml	CHPT1	Q8WUD6	NCBITaxon:9606	Homo sapiens	14	R-HSA-1482973	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane	yes	reactome/R-HSA-1482973.md	CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that the CHPT1 reaction occurs at the Golgi membrane; consistent with the experimental IDA. Accept.
human	CKB	genes/human/CKB/CKB-ai-review.yaml	CKB	P12277	NCBITaxon:9606	Homo sapiens	38	R-HSA-200318	creatine + ATP => phosphocreatine + ADP [CKB,CKM]	yes	reactome/R-HSA-200318.md	creatine + ATP => phosphocreatine + ADP [CKB,CKM]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing the creatine kinase reaction in the cytosol. Consistent with the core cytosolic localization. Accept.
human	CKM	genes/human/CKM/CKM-ai-review.yaml	CKM	P06732	NCBITaxon:9606	Homo sapiens	20	R-HSA-200318	creatine + ATP => phosphocreatine + ADP [CKB,CKM]	yes	reactome/R-HSA-200318.md	creatine + ATP => phosphocreatine + ADP [CKB,CKM]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct, specific subcellular location where the creatine kinase reaction occurs.
human	CKMT1A	genes/human/CKMT1A/CKMT1A-ai-review.yaml	CKMT1A	P12532	NCBITaxon:9606	Homo sapiens	16	R-HSA-200326	creatine + ATP => phosphocreatine + ADP [CK octamer]	yes	reactome/R-HSA-200326.md	creatine + ATP => phosphocreatine + ADP [CK octamer]	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization for the creatine kinase octamer reaction. Consistent with the peripheral, intermembrane-side inner-membrane localization of U-MtCK.
human	CKMT2	genes/human/CKMT2/CKMT2-ai-review.yaml	CKMT2	P17540	NCBITaxon:9606	Homo sapiens	15	R-HSA-200326	creatine + ATP => phosphocreatine + ADP [CK octamer]	yes	reactome/R-HSA-200326.md	creatine + ATP => phosphocreatine + ADP [CK octamer]	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Inner-membrane localization asserted by Reactome for the CK octamer; consistent with the curated UniProt subcellular location.
human	CLCN7	genes/human/CLCN7/CLCN7-ai-review.yaml	CLCN7	P51798	NCBITaxon:9606	Homo sapiens	30	R-HSA-2730959	CLCN7:OSTM1 exchanges Cl- for H+	yes	reactome/R-HSA-2730959.md	CLCN7:OSTM1 exchanges Cl- for H+	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Lysosomal membrane localization asserted in the Reactome reaction for CLCN7:OSTM1 Cl-/H+ exchange.
human	CLPS	genes/human/CLPS/CLPS-ai-review.yaml	CLPS	P04118	NCBITaxon:9606	Homo sapiens	10	R-HSA-192422	Digestion of triacylglycerols by extracellular PTL:colipase	yes	reactome/R-HSA-192422.md	Digestion of triacylglycerols by extracellular PTL:colipase	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Traceable author statement for extracellular localization.
human	CLPS	genes/human/CLPS/CLPS-ai-review.yaml	CLPS	P04118	NCBITaxon:9606	Homo sapiens	11	R-HSA-192434	Digestion of diacylglycerols by extracellular PTL:colipase	yes	reactome/R-HSA-192434.md	Digestion of diacylglycerols by extracellular PTL:colipase	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Traceable author statement for extracellular localization.
human	CLPS	genes/human/CLPS/CLPS-ai-review.yaml	CLPS	P04118	NCBITaxon:9606	Homo sapiens	12	R-HSA-975593	PNLIP:CLPS hydrolyses RPALM to atROL and PALM	yes	reactome/R-HSA-975593.md	PNLIP:CLPS hydrolyses RPALM to atROL and PALM	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Traceable author statement for extracellular localization.
human	CLPX	genes/human/CLPX/CLPX-ai-review.yaml	CLPX	O76031	NCBITaxon:9606	Homo sapiens	16	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome event placing CLPXP (and CLPX) in the mitochondrial matrix where it binds matrix protein substrates.
human	CLPX	genes/human/CLPX/CLPX-ai-review.yaml	CLPX	O76031	NCBITaxon:9606	Homo sapiens	17	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome event placing CLPXP in the mitochondrial matrix where it degrades matrix protein substrates.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	50	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for ALK mutants binding TKIs. Cytosolic localization reflects clathrin pool available for coat assembly.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	51	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	52	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	53	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	54	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	55	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	56	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	57	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	58	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Duplicate cytosol localization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	73	R-HSA-8856808	Recruitment of AP-2 complex and clathrin	yes	reactome/R-HSA-8856808.md	Recruitment of AP-2 complex and clathrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Recruitment of AP-2 complex and clathrin.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	74	R-HSA-8856813	AAK1 phosphorylates AP-2 mu subunit at T156	yes	reactome/R-HSA-8856813.md	AAK1 phosphorylates AP-2 mu subunit at T156	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: AAK1 phosphorylates AP-2 mu subunit.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	75	R-HSA-8862280	FCHo proteins bind nascent clathrin-coated pit	yes	reactome/R-HSA-8862280.md	FCHo proteins bind nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: FCHo proteins bind nascent clathrin-coated pit.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	76	R-HSA-8866283	ARRB recruits GPCRs into clathrin-coated pits	yes	reactome/R-HSA-8866283.md	ARBB recruits GPCRs into clathrin-coated pits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: ARRB recruits GPCRs into clathrin-coated pits.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	77	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: F- and N-BAR domain proteins bind clathrin-coated pit.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	78	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: CLASP proteins and cargo recruitment.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	79	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Clathrin recruits PIK3C2A.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	80	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Clathrin-associated PIK3C2A phosphorylates PI(4)P.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	81	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: SNX9 recruits actin polymerizing machinery.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	82	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: BAR domain proteins recruit dynamin.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	83	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: SYNJ hydrolyzes PI(4,5)P2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	84	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Endophilins recruit synaptojanins.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	85	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: HSPA8-mediated ATP hydrolysis promotes uncoating.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	86	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Clathrin recruits auxilins.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	87	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Auxilin recruits HSPA8:ATP.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	88	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dynamin-mediated vesicle scission.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	89	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dissociation of clathrin-associated proteins.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	90	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dissociation of AAK1 and dephosphorylation of AP-2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	91	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: RAB5 and GAPVD1 bind AP-2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	92	R-HSA-8871196	Initial binding of AP-2 and clathrin to PI(4,5)P2	yes	reactome/R-HSA-8871196.md	Initial binding of AP-2 and clathrin to PI(4,5)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Initial binding of AP-2 and clathrin to PI(4,5)P2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	93	R-HSA-2130486	Uncoating of clathrin-coated vesicles and fusion with endosomes	yes	reactome/R-HSA-2130486.md	Uncoating of clathrin-coated vesicles and fusion with endosomes	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Uncoating of clathrin-coated vesicles and fusion with endosomes.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	94	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Internalization of MHC II:Ii clathrin coated vesicle.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	95	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PCSK9:LDLR:Clathrin-coated vesicle transport.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	96	R-HSA-6784738	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	yes	reactome/R-HSA-6784738.md	Degradation of PCSK9:LDLR:Clathrin-coated vesicle	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Degradation of PCSK9:LDLR complex.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	97	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0036020	endolysosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: VLDLR:PCSK9:Clathrin-coated vesicle transport.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	106	R-HSA-5333658	CLAT:AP1:CLVS bind PI(3,5)P2	yes	reactome/R-HSA-5333658.md	CLAT:AP1:CLVS bind PI(3,5)P2	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: CLAT:AP1:CLVS bind PI(3,5)P2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	112	R-HSA-177479	Axonal transport of NGF:Trk complexes	yes	reactome/R-HSA-177479.md	Axonal transport of NGF:Trk complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Axonal transport of NGF:Trk complexes.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	113	R-HSA-2130640	Recruitment of clathrin coated vesicle by Ii	yes	reactome/R-HSA-2130640.md	Recruitment of clathrin coated vesicle by Ii	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Recruitment of clathrin coated vesicle by Ii.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	114	R-HSA-2130725	Internalization of MHC II:Ii clathrin coated vesicle	yes	reactome/R-HSA-2130725.md	Internalization of MHC II:Ii clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: MHC II:Ii clathrin coated vesicle internalization.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	115	R-HSA-392748	L1 binds to AP-2 Clathrin complex	yes	reactome/R-HSA-392748.md	L1 binds to AP-2 Clathrin complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: L1 binds to AP-2 Clathrin complex.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	116	R-HSA-392749	Transport of L1 into endosomes	yes	reactome/R-HSA-392749.md	Transport of L1 into endosomes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Transport of L1 into endosomes.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	117	R-HSA-445071	Reinsertion of L1 into the plasma membrane	yes	reactome/R-HSA-445071.md	Reinsertion of L1 into the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Reinsertion of L1 into plasma membrane.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	118	R-HSA-445079	Phosphorylation of L1 by ERK	yes	reactome/R-HSA-445079.md	Phosphorylation of L1 by ERK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Phosphorylation of L1 by ERK.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	119	R-HSA-5138433	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	yes	reactome/R-HSA-5138433.md	p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: DVL2 recruits AP-2 and beta-arrestin 2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	120	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: WNT5A:FZD4 endocytosis.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	121	R-HSA-555065	Formation of clathrin coated vesicle	yes	reactome/R-HSA-555065.md	Formation of clathrin coated vesicle	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Formation of clathrin coated vesicle.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	122	R-HSA-6784729	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	yes	reactome/R-HSA-6784729.md	PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PCSK9:LDLR transport.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	123	R-HSA-6784735	PCSK9:LDLR bind to Clathrin	yes	reactome/R-HSA-6784735.md	PCSK9:LDLR bind to Clathrin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PCSK9:LDLR bind Clathrin.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	124	R-HSA-8855130	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	yes	reactome/R-HSA-8855130.md	VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: VLDLR:PCSK9 transport.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	125	R-HSA-8855131	VLDLR:PCSK9 binds Clathrin-coated vesicles	yes	reactome/R-HSA-8855131.md	VLDLR:PCSK9 binds Clathrin-coated vesicles	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: VLDLR:PCSK9 binds clathrin.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	126	R-HSA-8866279	Epsin family proteins bind ubiquitinated cargo	yes	reactome/R-HSA-8866279.md	Epsin family proteins bind ubiquitinated cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Epsin binds ubiquitinated cargo.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	127	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: BAR domain proteins bind clathrin-coated pit.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	128	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: CLASP proteins and cargo recruitment.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	129	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Clathrin recruits PIK3C2A.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	130	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: PIK3C2A phosphorylates PI(4)P.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	131	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: SNX9 recruits actin machinery.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	132	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: BAR proteins recruit dynamin.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	133	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: SYNJ hydrolyzes PI(4,5)P2.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	134	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Endophilins recruit synaptojanins.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	135	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dynamin-mediated vesicle scission.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	136	R-HSA-5138459	WNT5A:FZD4 is endocytosed	yes	reactome/R-HSA-5138459.md	WNT5A:FZD4 is endocytosed	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: WNT5A:FZD4 endocytosis.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	141	R-HSA-2130619	TGN-lysosomal vesicle coat assembly	yes	reactome/R-HSA-2130619.md	TGN-lysosomal vesicle coat assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN-lysosomal vesicle coat assembly.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	142	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN-lysosome vesicle uncoating.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	143	R-HSA-421831	trans-Golgi Network Coat Assembly	yes	reactome/R-HSA-421831.md	trans-Golgi Network Coat Assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: trans-Golgi Network Coat Assembly.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	144	R-HSA-421835	trans-Golgi Network Vesicle Scission	yes	reactome/R-HSA-421835.md	trans-Golgi Network Vesicle Scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: trans-Golgi Network Vesicle Scission.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	145	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: trans-Golgi Network Derived Vesicle Uncoating.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	146	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN Derived Lysosomal Vesicle Uncoating.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	147	R-HSA-432706	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	yes	reactome/R-HSA-432706.md	trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN Lysosome Vesicle Coat Assembly.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	148	R-HSA-432707	trans-Golgi Network Lysosomal Vesicle Scission	yes	reactome/R-HSA-432707.md	trans-Golgi Network Lysosomal Vesicle Scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN Lysosomal Vesicle Scission.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	149	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dissociation of Arf1:GDP, AP-1 Clathrin coated complex.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	150	R-HSA-2130641	Translocation of TGN-lysosome vesicle to lysosome	yes	reactome/R-HSA-2130641.md	Translocation of TGN-lysosome vesicle to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Translocation of TGN-lysosome vesicle.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	151	R-HSA-2213236	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	yes	reactome/R-HSA-2213236.md	TGN-lysosome vesicle uncoating and release of nonameric complex to lysosome	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: TGN-lysosome vesicle uncoating.
human	CLTC	genes/human/CLTC/CLTC-ai-review.yaml	CLTC	Q00610	NCBITaxon:9606	Homo sapiens	152	R-HSA-8951498	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	yes	reactome/R-HSA-8951498.md	Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway: Dissociation of AP-1 clathrin complex.
human	CLU	genes/human/CLU/CLU-ai-review.yaml	CLU	P10909	NCBITaxon:9606	Homo sapiens	107	R-HSA-6810643	EPPIN protein complex binds bacteria	yes	reactome/R-HSA-6810643.md	EPPIN protein complex binds bacteria	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-6810643 describes the EPPIN protein complex binding bacteria. CLU is part of the EPPIN complex on spermatozoa (PMID:17567961). Extracellular region localization is consistent.
human	CLU	genes/human/CLU/CLU-ai-review.yaml	CLU	P10909	NCBITaxon:9606	Homo sapiens	108	R-HSA-8852580	Clusterin binds C5b-C7, C8, C9	yes	reactome/R-HSA-8852580.md	Clusterin binds C5b-C7, C8, C9	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-8852580 describes CLU binding C5b-C7, C8, C9 complement components. This is the core complement regulatory function occurring in the extracellular space.
human	CLU	genes/human/CLU/CLU-ai-review.yaml	CLU	P10909	NCBITaxon:9606	Homo sapiens	135	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-481007 describes exocytosis of platelet alpha granule contents. CLU is released from platelet alpha granules into the extracellular space upon platelet activation.
human	CLU	genes/human/CLU/CLU-ai-review.yaml	CLU	P10909	NCBITaxon:9606	Homo sapiens	136	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome R-HSA-481007 describes CLU as a component of platelet alpha granule contents that are released upon platelet activation.
human	CMAS	genes/human/CMAS/CMAS-ai-review.yaml	CMAS	Q8NFW8	NCBITaxon:9606	Homo sapiens	9	R-HSA-4084982	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac	yes	reactome/R-HSA-4084982.md	CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author-statement placing CMAS in the nucleoplasm. Reactome states that CMAS localizes to the nucleus in mammalian cells; nucleoplasm is a reasonable sub-nuclear compartment consistent with the experimental nuclear localization. Kept as a valid but non-core localization detail.
human	CNOT4	genes/human/CNOT4/CNOT4-ai-review.yaml	CNOT4	O95628	NCBITaxon:9606	Homo sapiens	24	R-HSA-429955	CCR4-NOT complex deadenylates mRNA	yes	reactome/R-HSA-429955.md	CCR4-NOT complex deadenylates mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation associated with the CCR4-NOT deadenylation reaction. Consistent with the cytoplasmic localization of CNOT4 and CCR4-NOT.
human	CNOT4	genes/human/CNOT4/CNOT4-ai-review.yaml	CNOT4	O95628	NCBITaxon:9606	Homo sapiens	25	R-HSA-6798044	BTG2 binds CCR4-NOT complex	yes	reactome/R-HSA-6798044.md	BTG2 binds CCR4-NOT complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation associated with BTG2 binding to the CCR4-NOT complex. Redundant with the other cytosol annotations and consistent with CNOT4's cytoplasmic localization.
human	CNPY3	genes/human/CNPY3/CNPY3-ai-review.yaml	CNPY3	Q9BT09	NCBITaxon:9606	Homo sapiens	8	R-HSA-1678923	TLR folding by chaperones GP96 and CNPY3	yes	reactome/R-HSA-1678923.md	TLR folding by chaperones GP96 and CNPY3	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome (event ""TLR folding by chaperones GP96 and CNPY3"") placing CNPY3 in the ER lumen, where it acts as a co-chaperone with HSP90B1/gp96. Consistent with the signal-peptide-cleaved, ER-luminal topology of CNPY3."
human	CNPY3	genes/human/CNPY3/CNPY3-ai-review.yaml	CNPY3	Q9BT09	NCBITaxon:9606	Homo sapiens	9	R-HSA-1678944	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex	yes	reactome/R-HSA-1678944.md	Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome (event ""Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex"") placing CNPY3 in the ER lumen as part of the GP96:CNPY3 TLR-folding complex."
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	11	R-HSA-9865350	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	yes	reactome/R-HSA-9865350.md	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	12	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	13	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA3	genes/human/COA3/COA3-ai-review.yaml	COA3	Q9Y2R0	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing COA3 at the mitochondrial inner membrane within the complex IV assembly pathway.
human	COA5	genes/human/COA5/COA5-ai-review.yaml	COA5	Q86WW8	NCBITaxon:9606	Homo sapiens	8	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome places COA5 in the metallochaperone complex that inserts copper into MT-CO1 at the inner mitochondrial membrane. This reflects where the complex IV metal-center maturation reactions occur; COA5 is an IMS protein acting at the IMS-facing side of the inner membrane.
human	COA5	genes/human/COA5/COA5-ai-review.yaml	COA5	Q86WW8	NCBITaxon:9606	Homo sapiens	9	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome associates COA5-containing metallochaperone machinery with the inner-membrane step in which MT-CO1 and MT-CO2 pre-assembly complexes associate and heme moieties are installed during complex IV assembly.
human	COA5	genes/human/COA5/COA5-ai-review.yaml	COA5	Q86WW8	NCBITaxon:9606	Homo sapiens	10	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome associates COA5 with the inner-membrane metallochaperone reaction that inserts copper into MT-CO2 (CuA center) during complex IV assembly.
human	COASY	genes/human/COASY/COASY-ai-review.yaml	COASY	Q13057	NCBITaxon:9606	Homo sapiens	14	R-HSA-196783	Coenzyme A biosynthesis	yes	reactome/R-HSA-196783.md	Coenzyme A biosynthesis	Homo sapiens	GO:0015937	coenzyme A biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome pathway ""Coenzyme A biosynthesis"" — the core biological process, supported by authoritative pathway curation. Core process."
human	COASY	genes/human/COASY/COASY-ai-review.yaml	COASY	Q13057	NCBITaxon:9606	Homo sapiens	15	R-HSA-196773	COASY phosphorylates DP-CoA	yes	reactome/R-HSA-196773.md	COASY phosphorylates DP-CoA	Homo sapiens	GO:0004140	dephospho-CoA kinase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""COASY phosphorylates DP-CoA"" captures the DPCK activity by authoritative pathway curation. Consistent with the experimental evidence. Core molecular function."
human	COASY	genes/human/COASY/COASY-ai-review.yaml	COASY	Q13057	NCBITaxon:9606	Homo sapiens	16	R-HSA-196754	COASY transfers an adenylyl group from ATP to PPANT	yes	reactome/R-HSA-196754.md	COASY transfers an adenylyl group from ATP to PPANT	Homo sapiens	GO:0004595	pantetheine-phosphate adenylyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""COASY transfers an adenylyl group from ATP to PPANT"" captures the PPAT activity by authoritative pathway curation. Consistent with the experimental evidence. Core molecular function."
human	COASY	genes/human/COASY/COASY-ai-review.yaml	COASY	Q13057	NCBITaxon:9606	Homo sapiens	27	R-HSA-196754	COASY transfers an adenylyl group from ATP to PPANT	yes	reactome/R-HSA-196754.md	COASY transfers an adenylyl group from ATP to PPANT	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the PPAT reaction of COASY at the mitochondrial outer membrane, citing Zhyvoloup et al. 2003. This submitochondrial assignment conflicts with the newer matrix/inner-membrane (UniProt) and predominantly-cytosolic (Liu et al. 2025) data, so it is not treated as a core location; retained as experimentally-sourced non-core (TAS, not removed).
human	COASY	genes/human/COASY/COASY-ai-review.yaml	COASY	Q13057	NCBITaxon:9606	Homo sapiens	28	R-HSA-196773	COASY phosphorylates DP-CoA	yes	reactome/R-HSA-196773.md	COASY phosphorylates DP-CoA	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the DPCK reaction of COASY at the mitochondrial outer membrane, citing Zhyvoloup et al. 2003. As with the PPAT-reaction annotation, this conflicts with the matrix/cytosol evidence and is retained as non-core rather than removed.
human	COLGALT1	genes/human/COLGALT1/COLGALT1-ai-review.yaml	COLGALT1	Q8NBJ5	NCBITaxon:9606	Homo sapiens	4	R-HSA-1650814	Collagen biosynthesis and modifying enzymes	yes	reactome/R-HSA-1650814.md	Collagen biosynthesis and modifying enzymes	Homo sapiens	GO:0030199	collagen fibril organization	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	COLGALT1 contributes to collagen biosynthesis/modification, which is upstream of collagen fibril organization in the extracellular matrix. Its direct action is intracellular hydroxylysine galactosylation, not fibril assembly itself.
human	COLGALT1	genes/human/COLGALT1/COLGALT1-ai-review.yaml	COLGALT1	Q8NBJ5	NCBITaxon:9606	Homo sapiens	5	R-HSA-1981120	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	yes	reactome/R-HSA-1981120.md	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	Homo sapiens	GO:0050211	procollagen galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted procollagen galactosyltransferase activity, the core molecular function of COLGALT1.
human	COLGALT1	genes/human/COLGALT1/COLGALT1-ai-review.yaml	COLGALT1	Q8NBJ5	NCBITaxon:9606	Homo sapiens	10	R-HSA-1981120	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	yes	reactome/R-HSA-1981120.md	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization asserted by Reactome, consistent with direct experimental evidence that COLGALT1 is a soluble ER-lumen protein.
human	COLGALT1	genes/human/COLGALT1/COLGALT1-ai-review.yaml	COLGALT1	Q8NBJ5	NCBITaxon:9606	Homo sapiens	11	R-HSA-8948228	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides	yes	reactome/R-HSA-8948228.md	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization asserted by Reactome (COLGALT1/COLGALT2 binding lysyl-hydroxylated collagen propeptides), consistent with the soluble ER-lumen localization of the enzyme.
human	COLGALT1	genes/human/COLGALT1/COLGALT1-ai-review.yaml	COLGALT1	Q8NBJ5	NCBITaxon:9606	Homo sapiens	12	R-HSA-8948231	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates	yes	reactome/R-HSA-8948231.md	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization asserted by Reactome, consistent with the experimentally established soluble ER-lumen residence of COLGALT1.
human	COLGALT2	genes/human/COLGALT2/COLGALT2-ai-review.yaml	COLGALT2	Q8IYK4	NCBITaxon:9606	Homo sapiens	8	R-HSA-1650814	Collagen biosynthesis and modifying enzymes	yes	reactome/R-HSA-1650814.md	Collagen biosynthesis and modifying enzymes	Homo sapiens	GO:0030199	collagen fibril organization	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Pathway-level biological process annotation placing COLGALT2 within collagen biosynthesis and modification. COLGALT2 contributes to collagen post-translational modification, but its direct, evolved role is the galactosylation reaction rather than fibril organization per se, which is a downstream consequence of properly modified collagen.
human	COLGALT2	genes/human/COLGALT2/COLGALT2-ai-review.yaml	COLGALT2	Q8IYK4	NCBITaxon:9606	Homo sapiens	9	R-HSA-1981120	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	yes	reactome/R-HSA-1981120.md	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	Homo sapiens	GO:0050211	procollagen galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	Core molecular function captured from Reactome (galactosylation of collagen propeptide hydroxylysines). Concordant with the direct biochemical evidence.
human	COLGALT2	genes/human/COLGALT2/COLGALT2-ai-review.yaml	COLGALT2	Q8IYK4	NCBITaxon:9606	Homo sapiens	10	R-HSA-1981120	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	yes	reactome/R-HSA-1981120.md	Galactosylation of collagen propeptide hydroxylysines by procollagen galactosyltransferases 1, 2	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization from Reactome, consistent with the UniProt subcellular location and the C-terminal ER-retention signal.
human	COLGALT2	genes/human/COLGALT2/COLGALT2-ai-review.yaml	COLGALT2	Q8IYK4	NCBITaxon:9606	Homo sapiens	11	R-HSA-8948228	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides	yes	reactome/R-HSA-8948228.md	COLGALT1,COLGALT2 bind Lysyl hydroxylated collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization from a Reactome reaction (COLGALT1,COLGALT2 bind lysyl hydroxylated collagen propeptides). Redundant with the other ER lumen annotations but correct.
human	COLGALT2	genes/human/COLGALT2/COLGALT2-ai-review.yaml	COLGALT2	Q8IYK4	NCBITaxon:9606	Homo sapiens	12	R-HSA-8948231	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates	yes	reactome/R-HSA-8948231.md	COLGALT1,COLGALT2:Galactosyl-hydroxylysyl collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization from a Reactome reaction (dissociation of COLGALT enzymes from galactosyl-hydroxylysyl collagen propeptides). Redundant but correct.
human	COMP	genes/human/COMP/COMP-ai-review.yaml	COMP	P49747	NCBITaxon:9606	Homo sapiens	63	R-HSA-2424252	COMP binds collagen, fibronectin, aggrecan and matrilins	yes	reactome/R-HSA-2424252.md	COMP binds collagen, fibronectin, aggrecan and matrilins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for COMP binding to ECM components.
human	COMP	genes/human/COMP/COMP-ai-review.yaml	COMP	P49747	NCBITaxon:9606	Homo sapiens	64	R-HSA-2426259	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47	yes	reactome/R-HSA-2426259.md	COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for COMP integrin interactions.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	18	R-HSA-264444	Autoubiquitination of phospho-COP1(Ser-387 )	yes	reactome/R-HSA-264444.md	Autoubiquitination of phospho-COP1(Ser-387 )	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	TAS (Reactome) assignment of ubiquitin-protein transferase activity, capturing COP1 autoubiquitination. This is a correct molecular-function term for COP1's E3 ligase activity (a parent/sibling of GO:0061630).
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	26	R-HSA-264418	Translocation of COP1 from the nucleus to the cytoplasm	yes	reactome/R-HSA-264418.md	Translocation of COP1 from the nucleus to the cytoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (TAS), modeling COP1 nucleus-to-cytoplasm translocation. Consistent with the documented cytoplasmic pool of COP1.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	27	R-HSA-264444	Autoubiquitination of phospho-COP1(Ser-387 )	yes	reactome/R-HSA-264444.md	Autoubiquitination of phospho-COP1(Ser-387 )	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (TAS), modeling COP1 autoubiquitination of phospho-COP1(Ser387). Consistent with the cytoplasmic pool of COP1.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	28	R-HSA-264458	Proteasome mediated degradation of COP1	yes	reactome/R-HSA-264458.md	Proteasome mediated degradation of COP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization from Reactome (TAS), modeling proteasome-mediated degradation of COP1. Consistent with the cytoplasmic pool of COP1.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	29	R-HSA-264418	Translocation of COP1 from the nucleus to the cytoplasm	yes	reactome/R-HSA-264418.md	Translocation of COP1 from the nucleus to the cytoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS), modeling COP1 nuclear-to-cytoplasmic translocation. Consistent with COP1's documented nuclear pool and nuclear-speckle localization.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	30	R-HSA-264435	Dissociation of the COP1-p53 complex	yes	reactome/R-HSA-264435.md	Dissociation of the COP1-p53 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS), modeling dissociation of the COP1-p53 complex. Consistent with COP1's nuclear pool where it regulates p53.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	31	R-HSA-349444	Phosphorylation of COP1 at Ser-387 by ATM	yes	reactome/R-HSA-349444.md	Phosphorylation of COP1 at Ser-387 by ATM	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS), modeling ATM phosphorylation of COP1 at Ser387 in the nucleus following DNA damage. Consistent with COP1's nuclear pool.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	32	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS) within the CRL4 neddylation cycle (NEDD8 transfer to the CRL4 complex). Consistent with COP1's nuclear CRL4-associated pool.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	33	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS) within the CRL4 neddylation cycle (NEDD8:UBE2M binding the CRL4 complex). Consistent with COP1's nuclear CRL4 pool.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	34	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS) within the CRL4 regulatory cycle (CAND1 binding the nuclear CRL4 complex). Consistent with COP1's nuclear CRL4 pool.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	35	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS) within the CRL4 regulatory cycle (COMMDs displacing CAND1 from the CRL4 complex). Consistent with COP1's nuclear CRL4 pool.
human	COP1	genes/human/COP1/COP1-ai-review.yaml	COP1	Q8NHY2	NCBITaxon:9606	Homo sapiens	36	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from Reactome (TAS) within the CRL4 regulatory cycle (COP9 signalosome deneddylation of the nuclear CRL4 complex). Consistent with COP1's nuclear CRL4 pool.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	28	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization during retrograde vesicle tethering at the ER.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	29	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization during COPI vesicle uncoating at the ER.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	30	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during vesicle tethering through GOLGA2:GORASP1.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	31	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during COPI vesicle uncoating.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	32	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during SNARE binding on tethered vesicle.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	33	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ARFGAPs stimulate ARF GTPase activity.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	34	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ERGIC-to-Golgi vesicle binding to dynein.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	35	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during vesicle tethering.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	36	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ARFGAPs stimulate ARF GTPase activity at Golgi.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	37	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during retrograde vesicle tethering at ER.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	38	R-HSA-6811426	Retrograde COPI vesicles bind kinesin and microtubules	yes	reactome/R-HSA-6811426.md	Retrograde COPI vesicles bind kinesin and microtubules	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during retrograde COPI vesicle binding to kinesin.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	39	R-HSA-6807872	Active ARF recruits coatomer	yes	reactome/R-HSA-6807872.md	Active ARF recruits coatomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during active ARF recruits coatomer step.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	41	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAPs stimulate ARF GTPase activity.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	42	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during COPI vesicle uncoating.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	43	R-HSA-6811412	Active ARF recruits coatomer to the Golgi	yes	reactome/R-HSA-6811412.md	Active ARF recruits coatomer to the Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during active ARF recruits coatomer to the Golgi.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	44	R-HSA-6811417	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	yes	reactome/R-HSA-6811417.md	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during cargo and adaptor binding at Golgi.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	45	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAPs stimulate ARF GTPase activity at Golgi membrane.
human	COPG1	genes/human/COPG1/COPG1-ai-review.yaml	COPG1	Q9Y678	NCBITaxon:9606	Homo sapiens	46	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during COPI vesicle uncoating at the ER.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	27	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization during retrograde vesicle tethering at the ER.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	28	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization during COPI vesicle uncoating at the ER.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	29	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during vesicle tethering.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	30	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during COPI vesicle uncoating.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	31	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane localization during SNARE binding on tethered vesicle.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	32	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ARFGAPs stimulate ARF GTPase activity.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	33	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ERGIC-to-Golgi vesicle binding to dynein.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	34	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during vesicle tethering.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	35	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during ARFGAPs stimulate ARF GTPase activity at Golgi.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	36	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during retrograde vesicle tethering at ER.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	37	R-HSA-6811426	Retrograde COPI vesicles bind kinesin and microtubules	yes	reactome/R-HSA-6811426.md	Retrograde COPI vesicles bind kinesin and microtubules	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Transport vesicle localization during retrograde COPI vesicle binding to kinesin.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	38	R-HSA-6807872	Active ARF recruits coatomer	yes	reactome/R-HSA-6807872.md	Active ARF recruits coatomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during active ARF recruits coatomer step.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	39	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAPs stimulate ARF GTPase activity.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	41	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during COPI vesicle uncoating.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	42	R-HSA-6811412	Active ARF recruits coatomer to the Golgi	yes	reactome/R-HSA-6811412.md	Active ARF recruits coatomer to the Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during active ARF recruits coatomer to the Golgi.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	43	R-HSA-6811417	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	yes	reactome/R-HSA-6811417.md	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during cargo and adaptor binding at Golgi.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	44	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during ARFGAPs stimulate ARF GTPase activity at Golgi membrane.
human	COPG2	genes/human/COPG2/COPG2-ai-review.yaml	COPG2	Q9UBF2	NCBITaxon:9606	Homo sapiens	45	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization during COPI vesicle uncoating at the ER.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	31	R-HSA-8863721	NEDD8-STON binds TOR1 hexamer and COP9 complex	yes	reactome/R-HSA-8863721.md	NEDD8-STON binds TOR1 hexamer and COP9 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN involvement in TOR1/STON deneddylation pathway. Cytosolic localization is consistent with biochemical evidence.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	32	R-HSA-8863723	COP9 and TOR1 deneddylate STON2	yes	reactome/R-HSA-8863723.md	COP9 and TOR1 deneddylate STON2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for COP9 and TOR1 deneddylation activity. Duplicate localization annotation for same compartment.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	33	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN deneddylation of cytosolic CRL E3 ubiquitin ligase complexes.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	34	R-HSA-5691006	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	yes	reactome/R-HSA-5691006.md	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for XPC:RAD23:CETN2 and UV-DDB binding to distorted DNA in nucleotide excision repair context.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	35	R-HSA-6781833	ERCC8 (CSA) binds stalled RNA Pol II	yes	reactome/R-HSA-6781833.md	ERCC8 (CSA) binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ERCC8 (CSA) binding stalled RNA Pol II, relevant to transcription-coupled repair.
human	COPS2	genes/human/COPS2/COPS2-ai-review.yaml	COPS2	P61201	NCBITaxon:9606	Homo sapiens	36	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN deneddylation of nuclear CRL4 E3 ubiquitin ligase complex.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	30	R-HSA-8863721	NEDD8-STON binds TOR1 hexamer and COP9 complex	yes	reactome/R-HSA-8863721.md	NEDD8-STON binds TOR1 hexamer and COP9 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN localization in cytosol based on NEDD8-related pathway. Consistent with experimental evidence.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	31	R-HSA-8863723	COP9 and TOR1 deneddylate STON2	yes	reactome/R-HSA-8863723.md	COP9 and TOR1 deneddylate STON2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN in cytosol involved in deneddylation.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	32	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN deneddylation of cytosolic CRL complexes.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	33	R-HSA-5691006	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	yes	reactome/R-HSA-5691006.md	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN in nucleoplasm involved in DNA damage recognition in global genome nucleotide excision repair.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	34	R-HSA-6781833	ERCC8 (CSA) binds stalled RNA Pol II	yes	reactome/R-HSA-6781833.md	ERCC8 (CSA) binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN in nucleoplasm involved in transcription-coupled nucleotide excision repair.
human	COPS8	genes/human/COPS8/COPS8-ai-review.yaml	COPS8	Q99627	NCBITaxon:9606	Homo sapiens	35	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CSN deneddylation of nuclear CRL4 complex.
human	COQ2	genes/human/COQ2/COQ2-ai-review.yaml	COQ2	Q96H96	NCBITaxon:9606	Homo sapiens	11	R-HSA-2142789	Ubiquinol biosynthesis	yes	reactome/R-HSA-2142789.md	Ubiquinol biosynthesis	Homo sapiens	GO:0006744	ubiquinone biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author assignment of the core BP (Ubiquinol biosynthesis pathway). Correct and core.
human	COQ2	genes/human/COQ2/COQ2-ai-review.yaml	COQ2	Q96H96	NCBITaxon:9606	Homo sapiens	12	R-HSA-2162192	COQ2 ligates all-E-10PrP2 to PHB	yes	reactome/R-HSA-2162192.md	COQ2 ligates all-E-10PrP2 to PHB	Homo sapiens	GO:0008412	4-hydroxybenzoate polyprenyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assignment of the defining molecular function, describing the reaction in which COQ2 ligates all-trans-decaprenyl diphosphate to 4-hydroxybenzoate to form 3-decaprenyl-4-hydroxybenzoate. Correct and core.
human	COQ2	genes/human/COQ2/COQ2-ai-review.yaml	COQ2	Q96H96	NCBITaxon:9606	Homo sapiens	23	R-HSA-2162192	COQ2 ligates all-E-10PrP2 to PHB	yes	reactome/R-HSA-2162192.md	COQ2 ligates all-E-10PrP2 to PHB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author assignment of the inner-membrane location, redundant with the experimental IDA annotation to the same term. Correct.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	12	R-HSA-2142789	Ubiquinol biosynthesis	yes	reactome/R-HSA-2142789.md	Ubiquinol biosynthesis	Homo sapiens	GO:0006744	ubiquinone biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author statement placing COQ4 in ubiquinol biosynthesis. Consistent with the core biological process.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	13	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0120539	4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""COQ4 decarboxylates MHDB"" assigns the C1 decarboxylase activity to COQ4. Consistent with the experimentally established core molecular function."
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	27	R-HSA-2162186	COQ3 methylates DeMQ10H2	yes	reactome/R-HSA-2162186.md	COQ3 methylates DeMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane. Consistent with the experimentally supported location.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	28	R-HSA-2162187	COQ6 hydroxylates DHB	yes	reactome/R-HSA-2162187.md	COQ6 hydroxylates DHB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane (redundant Reactome reaction). Consistent with the supported location.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	29	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane (redundant Reactome reaction). Consistent with the supported location.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	30	R-HSA-2162193	COQ3 methylates DHDB	yes	reactome/R-HSA-2162193.md	COQ3 methylates DHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane (redundant Reactome reaction). Consistent with the supported location.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	31	R-HSA-2162194	COQ7:COQ9 octamer hydroxylates DMQ10H2	yes	reactome/R-HSA-2162194.md	COQ7:COQ9 octamer hydroxylates DMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane (redundant Reactome reaction). Consistent with the supported location.
human	COQ4	genes/human/COQ4/COQ4-ai-review.yaml	COQ4	Q9Y3A0	NCBITaxon:9606	Homo sapiens	32	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial inner membrane, associated with the COQ4 decarboxylation reaction. Consistent with the supported location.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	9	R-HSA-2142789	Ubiquinol biosynthesis	yes	reactome/R-HSA-2142789.md	Ubiquinol biosynthesis	Homo sapiens	GO:0006744	ubiquinone biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Correct core BP asserted by Reactome (Ubiquinol biosynthesis); redundant with experimental evidence but accurately captures COQ5's role.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	10	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0008425	2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity	TAS	enables	MF	false		ACCEPT	"Correct core MF asserted by Reactome for the COQ5-catalyzed methylation reaction (R-HSA-2162188 ""COQ5 methylates MDMQ10H2""); consistent with the experimental IDA annotations."
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	15	R-HSA-2162186	COQ3 methylates DeMQ10H2	yes	reactome/R-HSA-2162186.md	COQ3 methylates DeMQ10H2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome; this Reactome reaction is the COQ3 step but Reactome co-annotates all COQ synthome members to the mitochondrial matrix. Concordant with the experimental IDA matrix annotation.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	16	R-HSA-2162187	COQ6 hydroxylates DHB	yes	reactome/R-HSA-2162187.md	COQ6 hydroxylates DHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome (COQ6 reaction step, co-annotated to the synthome). Concordant with the experimental IDA matrix annotation.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	17	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome for the COQ5 methylation reaction step (R-HSA-2162188). Concordant with the experimental IDA matrix annotation.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	18	R-HSA-2162193	COQ3 methylates DHDB	yes	reactome/R-HSA-2162193.md	COQ3 methylates DHDB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome (COQ3 reaction step, co-annotated to the synthome). Concordant with the experimental IDA matrix annotation.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	19	R-HSA-2162194	COQ7:COQ9 octamer hydroxylates DMQ10H2	yes	reactome/R-HSA-2162194.md	COQ7:COQ9 octamer hydroxylates DMQ10H2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome (COQ7:COQ9 reaction step, co-annotated to the synthome). Concordant with the experimental IDA matrix annotation.
human	COQ5	genes/human/COQ5/COQ5-ai-review.yaml	COQ5	Q5HYK3	NCBITaxon:9606	Homo sapiens	20	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix-side localization asserted by Reactome (COQ4 reaction step, co-annotated to the synthome). Concordant with the experimental IDA matrix annotation.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	23	R-HSA-2162186	COQ3 methylates DeMQ10H2	yes	reactome/R-HSA-2162186.md	COQ3 methylates DeMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the inner membrane, correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	24	R-HSA-2162187	COQ6 hydroxylates DHB	yes	reactome/R-HSA-2162187.md	COQ6 hydroxylates DHB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization (COQ6 hydroxylates DHB reaction), correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	25	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the inner membrane, correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	26	R-HSA-2162193	COQ3 methylates DHDB	yes	reactome/R-HSA-2162193.md	COQ3 methylates DHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the inner membrane, correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	27	R-HSA-2162194	COQ7:COQ9 octamer hydroxylates DMQ10H2	yes	reactome/R-HSA-2162194.md	COQ7:COQ9 octamer hydroxylates DMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the inner membrane, correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ6	genes/human/COQ6/COQ6-ai-review.yaml	COQ6	Q9Y2Z9	NCBITaxon:9606	Homo sapiens	28	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the inner membrane, correct but duplicating the experimental IDA call retained as core. Kept as non-core.
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	21	R-HSA-2162186	COQ3 methylates DeMQ10H2	yes	reactome/R-HSA-2162186.md	COQ3 methylates DeMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived location for a specific CoQ pathway reaction event. Correct core inner-membrane location (one of several redundant Reactome duplicates). Accept.
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	22	R-HSA-2162187	COQ6 hydroxylates DHB	yes	reactome/R-HSA-2162187.md	COQ6 hydroxylates DHB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Redundant Reactome-derived inner-membrane location for another CoQ pathway event. Correct core location. Accept.
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	23	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Redundant Reactome-derived inner-membrane location. Correct core location. Accept.
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	24	R-HSA-2162193	COQ3 methylates DHDB	yes	reactome/R-HSA-2162193.md	COQ3 methylates DHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Redundant Reactome-derived inner-membrane location. Correct core location. Accept.
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	25	R-HSA-2162194	COQ7:COQ9 octamer hydroxylates DMQ10H2	yes	reactome/R-HSA-2162194.md	COQ7:COQ9 octamer hydroxylates DMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome event ""COQ7:COQ9 octamer hydroxylates DMQ10H2"" — directly describes the COQ7 catalytic step at the inner membrane. Correct core inner-membrane location (one of several redundant Reactome duplicates). Accept."
human	COQ7	genes/human/COQ7/COQ7-ai-review.yaml	COQ7	Q99807	NCBITaxon:9606	Homo sapiens	26	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Redundant Reactome-derived inner-membrane location. Correct core location. Accept.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	19	R-HSA-2162186	COQ3 methylates DeMQ10H2	yes	reactome/R-HSA-2162186.md	COQ3 methylates DeMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization associated with a CoQ-pathway reaction step (COQ3 methylates DeMQ10H2). COQ9 acts on the matrix face of the inner membrane within the CoQ synthome, so the compartment is correct.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	20	R-HSA-2162187	COQ6 hydroxylates DHB	yes	reactome/R-HSA-2162187.md	COQ6 hydroxylates DHB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization associated with a CoQ-pathway reaction step (COQ6 hydroxylates DHB). Compartment assignment is correct for COQ9.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	21	R-HSA-2162188	COQ5 methylates MDMQ10H2	yes	reactome/R-HSA-2162188.md	COQ5 methylates MDMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization associated with a CoQ-pathway reaction step (COQ5 methylates MDMQ10H2). Compartment assignment is correct for COQ9.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	22	R-HSA-2162193	COQ3 methylates DHDB	yes	reactome/R-HSA-2162193.md	COQ3 methylates DHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization associated with a CoQ-pathway reaction step (COQ3 methylates DHDB). Compartment assignment is correct for COQ9.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	23	R-HSA-2162194	COQ7:COQ9 octamer hydroxylates DMQ10H2	yes	reactome/R-HSA-2162194.md	COQ7:COQ9 octamer hydroxylates DMQ10H2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization for the reaction step directly involving COQ9 (COQ7:COQ9 octamer hydroxylates DMQ10H2). This is the specific step in which the COQ7:COQ9 module presents DMQ substrate for hydroxylation.
human	COQ9	genes/human/COQ9/COQ9-ai-review.yaml	COQ9	O75208	NCBITaxon:9606	Homo sapiens	24	R-HSA-2162195	COQ4 decarboxylates MHDB	yes	reactome/R-HSA-2162195.md	COQ4 decarboxylates MHDB	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome inner-membrane localization associated with a CoQ-pathway reaction step (COQ4 decarboxylates MHDB). Compartment assignment is correct for COQ9.
human	COX10	genes/human/COX10/COX10-ai-review.yaml	COX10	Q12887	NCBITaxon:9606	Homo sapiens	15	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Heme biosynthetic process is a correct broad parent of heme A biosynthesis.
human	COX10	genes/human/COX10/COX10-ai-review.yaml	COX10	Q12887	NCBITaxon:9606	Homo sapiens	16	R-HSA-2995330	COX10 transforms heme to heme O	yes	reactome/R-HSA-2995330.md	COX10 transforms heme to heme O	Homo sapiens	GO:0008495	protoheme IX farnesyltransferase activity	TAS	enables	MF	false		ACCEPT	COX10 converts protoheme IX/heme b and farnesyl diphosphate to heme O.
human	COX10	genes/human/COX10/COX10-ai-review.yaml	COX10	Q12887	NCBITaxon:9606	Homo sapiens	20	R-HSA-2995330	COX10 transforms heme to heme O	yes	reactome/R-HSA-2995330.md	COX10 transforms heme to heme O	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the COX10 heme O-forming reaction at the mitochondrial inner membrane.
human	COX11	genes/human/COX11/COX11-ai-review.yaml	COX11	Q9Y6N1	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization tied to the reaction in which the metallochaperone inserts Cu2+ into MT-CO1. Consistent with the experimental inner-membrane annotations and with COX11's copper-delivery role.
human	COX11	genes/human/COX11/COX11-ai-review.yaml	COX11	Q9Y6N1	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization associated with the CIV assembly reaction in which MT-CO1 and MT-CO2 complexes associate and heme moieties are installed. Consistent with COX11's established inner-membrane localization.
human	COX11	genes/human/COX11/COX11-ai-review.yaml	COX11	Q9Y6N1	NCBITaxon:9606	Homo sapiens	18	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization tied to the reaction in which the metallochaperone inserts 2 Cu2+ into MT-CO2. Consistent with COX11's established inner-membrane localization and its role in complex IV copper delivery.
human	COX14	genes/human/COX14/COX14-ai-review.yaml	COX14	Q96I36	NCBITaxon:9606	Homo sapiens	11	R-HSA-9865350	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	yes	reactome/R-HSA-9865350.md	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation placing COX14 in the mitochondrial inner membrane as a subunit of the MITRAC complex that binds nascent MT-CO1. This is the functionally correct location for COX14.
human	COX14	genes/human/COX14/COX14-ai-review.yaml	COX14	Q96I36	NCBITaxon:9606	Homo sapiens	12	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to mitochondrial inner membrane, from a MITRAC assembly reaction. Duplicate location supporting COX14's inner-membrane residence.
human	COX14	genes/human/COX14/COX14-ai-review.yaml	COX14	Q96I36	NCBITaxon:9606	Homo sapiens	13	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to mitochondrial inner membrane, from a MITRAC assembly reaction. Duplicate location supporting COX14's inner-membrane residence.
human	COX14	genes/human/COX14/COX14-ai-review.yaml	COX14	Q96I36	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to mitochondrial inner membrane, from a MITRAC assembly reaction. Duplicate location supporting COX14's inner-membrane residence.
human	COX14	genes/human/COX14/COX14-ai-review.yaml	COX14	Q96I36	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to mitochondrial inner membrane, from a MITRAC assembly reaction. Duplicate location supporting COX14's inner-membrane residence.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	10	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Heme biosynthetic process is a broad parent of the more precise heme A biosynthetic process.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	11	R-HSA-2995334	COX15 transforms heme O to heme A	yes	reactome/R-HSA-2995334.md	COX15 transforms heme O to heme A	Homo sapiens	GO:0120547	heme A synthase activity	TAS	enables	MF	false		ACCEPT	COX15 catalyzes conversion of heme O to heme A, the specific heme A synthase reaction.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	20	R-HSA-2995334	COX15 transforms heme O to heme A	yes	reactome/R-HSA-2995334.md	COX15 transforms heme O to heme A	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX15 is a multi-pass mitochondrial inner membrane enzyme.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	21	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX15 is a multi-pass mitochondrial inner membrane enzyme.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	22	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX15 is a multi-pass mitochondrial inner membrane enzyme.
human	COX15	genes/human/COX15/COX15-ai-review.yaml	COX15	Q7KZN9	NCBITaxon:9606	Homo sapiens	23	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX15 is a multi-pass mitochondrial inner membrane enzyme.
human	COX16	genes/human/COX16/COX16-ai-review.yaml	COX16	Q9P0S2	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) location annotation placing COX16 at the mitochondrial inner membrane within the Complex IV assembly reaction ""Metallochaperone inserts Cu2+ into MT-CO1""."
human	COX16	genes/human/COX16/COX16-ai-review.yaml	COX16	Q9P0S2	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) location annotation placing COX16 at the mitochondrial inner membrane within the reaction ""MT-CO1 and MT-CO2 complexes associate, installing heme moieties""."
human	COX16	genes/human/COX16/COX16-ai-review.yaml	COX16	Q9P0S2	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) location annotation placing COX16 at the mitochondrial inner membrane within the reaction ""Metallochaperone inserts 2Cu2+ into MT-CO2""."
human	COX18	genes/human/COX18/COX18-ai-review.yaml	COX18	Q8N8Q8	NCBITaxon:9606	Homo sapiens	11	R-HSA-9864848	Complex IV assembly	yes	reactome/R-HSA-9864848.md	Complex IV assembly	Homo sapiens	GO:0033617	mitochondrial respiratory chain complex IV assembly	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation placing COX18 in complex IV assembly. Concordant with the experimental evidence.
human	COX18	genes/human/COX18/COX18-ai-review.yaml	COX18	Q8N8Q8	NCBITaxon:9606	Homo sapiens	20	R-HSA-9902096	COX18 inserts nascent MT-CO2 in COX20:TMEM77	yes	reactome/R-HSA-9902096.md	COX18 inserts nascent MT-CO2 in COX20:TMEM77	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation of inner-membrane localisation, from the pathway describing COX18 inserting nascent MT-CO2 in the COX20:TMEM77 module.
human	COX20	genes/human/COX20/COX20-ai-review.yaml	COX20	Q5RI15	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author (TAS) inner-membrane localization associated with the reaction in which the metallochaperone inserts copper into MT-CO2. COX20 operates at the inner membrane in this step. Consistent with experimental data.
human	COX20	genes/human/COX20/COX20-ai-review.yaml	COX20	Q5RI15	NCBITaxon:9606	Homo sapiens	18	R-HSA-9902096	COX18 inserts nascent MT-CO2 in COX20:TMEM77	yes	reactome/R-HSA-9902096.md	COX18 inserts nascent MT-CO2 in COX20:TMEM77	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author (TAS) inner-membrane localization for the reaction in which COX18 inserts nascent MT-CO2 into the COX20:TMEM177 chaperone complex. COX20 acts at the inner membrane. Consistent with experimental data.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	25	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9865412 describes TIMM21-mediated transport of COX4, COX5A, COX6C to the MT-CO1:MITRAC complex. The IMS annotation reflects the C-terminal domain of COX4I1 that extends into the IMS.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	34	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-163214 (Electron transfer from reduced cytochrome c to molecular oxygen) places COX4I1 in the mitochondrial inner membrane as part of CIV.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	35	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9709406 (CO binds to Cytochrome c oxidase) places COX4I1 in the mitochondrial inner membrane. This pathway describes carbon monoxide binding to CIV.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	36	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9865412 (TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC) places COX4I1 in the inner membrane during CIV assembly.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	37	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9865449 (Metallochaperone inserts Cu2+ into MT-CO1) places COX4I1 in the inner membrane during copper insertion step of CIV assembly.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	38	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9865579 (MT-CO1 and MT-CO2 complexes associate, installing heme moieties) places COX4I1 in the inner membrane during CIV assembly.
human	COX4I1	genes/human/COX4I1/COX4I1-ai-review.yaml	COX4I1	P13073	NCBITaxon:9606	Homo sapiens	39	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-9865663 (MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex) places COX4I1 in the inner membrane during late CIV assembly.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	12	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	13	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX4I2 is annotated by UniProt and Reactome as a single-pass mitochondrial inner membrane component of Complex IV.
human	COX4I2	genes/human/COX4I2/COX4I2-ai-review.yaml	COX4I2	Q96KJ9	NCBITaxon:9606	Homo sapiens	18	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	The intermembrane-space annotation reflects the topology of COX4-family subunits and their exposure toward the cytochrome c side of Complex IV. COX4I2 should not be treated as a soluble IMS protein, but the topology statement is acceptable.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	19	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome (TAS) annotation places COX5A in the mitochondrial intermembrane space, but COX5A is experimentally a peripheral inner-membrane protein on the matrix side (UniProt). The IMS term reflects the reaction context (electrons originate from cytochrome c in the IMS) rather than the topology of COX5A itself, so it mislocalises the subunit.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	23	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation localising COX5A to the mitochondrial inner membrane in the context of the electron-transfer reaction. Correct and consistent with the experimental inner-membrane annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	24	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation from a complex IV reaction context. Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	25	R-HSA-9838627	AFG3L2 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838627.md	AFG3L2 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in the context of AFG3L2-mediated inner-membrane protein handling. Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	26	R-HSA-9839113	AFG3L2 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9839113.md	AFG3L2 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in the context of AFG3L2-mediated degradation of inner-membrane proteins. Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	27	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in the context of complex IV assembly (TIMM21 delivering COX4/COX5A/COX6C to the MT-CO1:MITRAC intermediate). Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	28	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in a complex IV assembly reaction (copper insertion into MT-CO1). Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	29	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in a complex IV assembly reaction (MT-CO1/MT-CO2 association and heme installation). Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5A	genes/human/COX5A/COX5A-ai-review.yaml	COX5A	P20674	NCBITaxon:9606	Homo sapiens	30	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localisation in a complex IV assembly reaction (MT-CO3, COX6A/B/7A and NDUFA4 binding the holo-MT-CO1,2 complex). Correct localisation for a complex IV subunit; redundant with the other GO:0005743 annotations.
human	COX5B	genes/human/COX5B/COX5B-ai-review.yaml	COX5B	P10606	NCBITaxon:9606	Homo sapiens	24	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for electron transfer from reduced cytochrome c to molecular oxygen - core Complex IV function.
human	COX5B	genes/human/COX5B/COX5B-ai-review.yaml	COX5B	P10606	NCBITaxon:9606	Homo sapiens	25	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction - CO binds to Cytochrome c oxidase. Documents Complex IV as inner membrane complex.
human	COX5B	genes/human/COX5B/COX5B-ai-review.yaml	COX5B	P10606	NCBITaxon:9606	Homo sapiens	26	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	LONP1 binds mitochondrial inner membrane proteins including Complex IV subunits.
human	COX5B	genes/human/COX5B/COX5B-ai-review.yaml	COX5B	P10606	NCBITaxon:9606	Homo sapiens	27	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	LONP1 degrades mitochondrial inner membrane proteins - part of protein quality control.
human	COX5B	genes/human/COX5B/COX5B-ai-review.yaml	COX5B	P10606	NCBITaxon:9606	Homo sapiens	28	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Complex IV assembly reaction - incorporation of nuclear-encoded subunits including COX5B into inner membrane complex.
human	COX6A1	genes/human/COX6A1/COX6A1-ai-review.yaml	COX6A1	P12074	NCBITaxon:9606	Homo sapiens	16	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6A1 is a single-pass mitochondrial inner membrane subunit of Complex IV.
human	COX6A1	genes/human/COX6A1/COX6A1-ai-review.yaml	COX6A1	P12074	NCBITaxon:9606	Homo sapiens	17	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6A1 is a single-pass mitochondrial inner membrane subunit of Complex IV.
human	COX6A1	genes/human/COX6A1/COX6A1-ai-review.yaml	COX6A1	P12074	NCBITaxon:9606	Homo sapiens	18	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6A1 is a single-pass mitochondrial inner membrane subunit of Complex IV.
human	COX6A2	genes/human/COX6A2/COX6A2-ai-review.yaml	COX6A2	Q02221	NCBITaxon:9606	Homo sapiens	9	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (electron transfer from reduced cytochrome c to molecular oxygen) places COX6A2 in the mitochondrial inner membrane as part of Complex IV. Correct.
human	COX6A2	genes/human/COX6A2/COX6A2-ai-review.yaml	COX6A2	Q02221	NCBITaxon:9606	Homo sapiens	10	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (CO binds to cytochrome c oxidase) localizes COX6A2 to the mitochondrial inner membrane as a Complex IV subunit. Correct location.
human	COX6A2	genes/human/COX6A2/COX6A2-ai-review.yaml	COX6A2	Q02221	NCBITaxon:9606	Homo sapiens	11	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome models the final Complex IV assembly step in which COX6A (with other subunits) binds the holo-MT-CO1,2 complex in the inner membrane. This both localizes COX6A2 to the inner membrane and supports its role in Complex IV assembly.
human	COX6B1	genes/human/COX6B1/COX6B1-ai-review.yaml	COX6B1	P14854	NCBITaxon:9606	Homo sapiens	17	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6B1 associates with Complex IV at the mitochondrial inner membrane on the intermembrane-space side.
human	COX6B1	genes/human/COX6B1/COX6B1-ai-review.yaml	COX6B1	P14854	NCBITaxon:9606	Homo sapiens	18	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6B1 associates with Complex IV at the mitochondrial inner membrane on the intermembrane-space side.
human	COX6B1	genes/human/COX6B1/COX6B1-ai-review.yaml	COX6B1	P14854	NCBITaxon:9606	Homo sapiens	19	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	COX6B1 associates with Complex IV at the mitochondrial inner membrane on the intermembrane-space side.
human	COX7B	genes/human/COX7B/COX7B-ai-review.yaml	COX7B	P24311	NCBITaxon:9606	Homo sapiens	15	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localization of COX7B to the mitochondrial inner membrane in the context of electron transfer from reduced cytochrome c to molecular oxygen. Consistent with the core localization.
human	COX7B	genes/human/COX7B/COX7B-ai-review.yaml	COX7B	P24311	NCBITaxon:9606	Homo sapiens	16	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of COX7B to the mitochondrial inner membrane (in the CO-binding-to-cytochrome-c-oxidase reaction context). Consistent with the core localization.
human	COX7B	genes/human/COX7B/COX7B-ai-review.yaml	COX7B	P24311	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of COX7B to the mitochondrial inner membrane (Complex IV assembly context, MT-CO1/MT-CO2 heme installation). Consistent with the core localization.
human	COX7B	genes/human/COX7B/COX7B-ai-review.yaml	COX7B	P24311	NCBITaxon:9606	Homo sapiens	18	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of COX7B to the mitochondrial inner membrane (Complex IV assembly context in which COX7B binds the holo-MT-CO1,2 complex). Consistent with the core localization.
human	COX8A	genes/human/COX8A/COX8A-ai-review.yaml	COX8A	P10176	NCBITaxon:9606	Homo sapiens	17	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localization to the mitochondrial inner membrane, in the context of electron transfer from cytochrome c to oxygen by Complex IV.
human	COX8A	genes/human/COX8A/COX8A-ai-review.yaml	COX8A	P10176	NCBITaxon:9606	Homo sapiens	18	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization associated with the CO-binding reaction of cytochrome c oxidase. Correct localization for COX8A as a Complex IV subunit.
human	COX8A	genes/human/COX8A/COX8A-ai-review.yaml	COX8A	P10176	NCBITaxon:9606	Homo sapiens	19	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization tied to the Complex IV assembly step at which COX8A is incorporated (association of MT-CO1/MT-CO2 with COX7B, COX7C, and COX8A).
human	COX8A	genes/human/COX8A/COX8A-ai-review.yaml	COX8A	P10176	NCBITaxon:9606	Homo sapiens	20	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization associated with the final Complex IV assembly step. Correct, duplicate localization annotation.
human	CPOX	genes/human/CPOX/CPOX-ai-review.yaml	CPOX	P36551	NCBITaxon:9606	Homo sapiens	18	R-HSA-189421	CPO transforms COPRO3 to PPGEN9	yes	reactome/R-HSA-189421.md	CPO transforms COPRO3 to PPGEN9	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) localization to the mitochondrial intermembrane space, where CPOX catalyzes conversion of coproporphyrinogen III to protoporphyrinogen IX. This is the primary curated compartment for the enzyme.
human	CPS1	genes/human/CPS1/CPS1-ai-review.yaml	CPS1	P31327	NCBITaxon:9606	Homo sapiens	51	R-HSA-70635	Urea cycle	yes	reactome/R-HSA-70635.md	Urea cycle	Homo sapiens	GO:0000050	urea cycle	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation of CPS1 in the urea cycle, the core biological process.
human	CPS1	genes/human/CPS1/CPS1-ai-review.yaml	CPS1	P31327	NCBITaxon:9606	Homo sapiens	54	R-HSA-9955543	CPS1 variants don't synthesize carbamoyl phosphate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to the mitochondrial matrix, the correct functional location of CPS1.
human	CPS1	genes/human/CPS1/CPS1-ai-review.yaml	CPS1	P31327	NCBITaxon:9606	Homo sapiens	55	R-HSA-9955504	SIRT5 deglutarylates CPS1	yes	reactome/R-HSA-9955504.md	SIRT5 deglutarylates CPS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (SIRT5 deglutarylation of CPS1) to the mitochondrial matrix, the correct functional location.
human	CPS1	genes/human/CPS1/CPS1-ai-review.yaml	CPS1	P31327	NCBITaxon:9606	Homo sapiens	66	R-HSA-70555	2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to the mitochondrial matrix (the CPS1 reaction event), the correct functional location.
human	CPS1	genes/human/CPS1/CPS1-ai-review.yaml	CPS1	P31327	NCBITaxon:9606	Homo sapiens	67	R-HSA-9959874	CPS1 gene expression	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to the mitochondrial matrix (CPS1 gene-expression event context), the correct functional location.
human	CPT1A	genes/human/CPT1A/CPT1A-ai-review.yaml	CPT1A	P50416	NCBITaxon:9606	Homo sapiens	31	R-HSA-200425	Carnitine shuttle	yes	reactome/R-HSA-200425.md	Carnitine shuttle	Homo sapiens	GO:0006853	carnitine shuttle	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing CPT1A in the carnitine shuttle pathway, where it catalyzes the initial acylcarnitine-forming step.
human	CPT1A	genes/human/CPT1A/CPT1A-ai-review.yaml	CPT1A	P50416	NCBITaxon:9606	Homo sapiens	45	R-HSA-200406	CPT1A transfers PALM to CAR	no				GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing CPT1A at the mitochondrial outer membrane, where it transfers palmitoyl to carnitine.
human	CPT2	genes/human/CPT2/CPT2-ai-review.yaml	CPT2	P23786	NCBITaxon:9606	Homo sapiens	15	R-HSA-200425	Carnitine shuttle	yes	reactome/R-HSA-200425.md	Carnitine shuttle	Homo sapiens	GO:0006853	carnitine shuttle	TAS	involved_in	BP	false		ACCEPT	Reactome (Carnitine shuttle pathway) traceable-author-statement assignment. CPT2 catalyzes the matrix-side acylcarnitine-to-acyl-CoA step of this pathway. Core process, correctly attributed.
human	CPT2	genes/human/CPT2/CPT2-ai-review.yaml	CPT2	P23786	NCBITaxon:9606	Homo sapiens	29	R-HSA-1989773	Expression of CPT2	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localization to the mitochondrial inner membrane. Correct; CPT2 is a peripheral inner-membrane protein on the matrix side.
human	CPT2	genes/human/CPT2/CPT2-ai-review.yaml	CPT2	P23786	NCBITaxon:9606	Homo sapiens	30	R-HSA-200410	CPT2 converts acylcarnitine to acyl-CoA	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (CPT2 converts acylcarnitine to acyl-CoA) traceable-author-statement localization to the mitochondrial inner membrane. Correct core localization.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	41	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This intracellular/granule localization is compatible with immune-cell trafficking context but is not the main functional site of CR1 complement receptor activity.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	42	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This intracellular/granule localization is compatible with immune-cell trafficking context but is not the main functional site of CR1 complement receptor activity.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	45	R-HSA-3266557	Factor I cleaves iC3b	yes	reactome/R-HSA-3266557.md	Factor I cleaves iC3b	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	46	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	47	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	48	R-HSA-8939088	CR1 gene expression is stimulated by RUNX1	yes	reactome/R-HSA-8939088.md	CR1 gene expression is stimulated by RUNX1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	49	R-HSA-977375	CR1 binds C3bBb/C4bC2a	yes	reactome/R-HSA-977375.md	CR1 binds C3bBb/C4bC2a	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	50	R-HSA-977602	Complement factor I binds to MCP, CR1:C4b, C3b	yes	reactome/R-HSA-977602.md	Complement factor I binds to MCP, CR1:C4b, C3b	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	51	R-HSA-977615	Factor I inactivates MCP/CR1-bound C4b/C3b	yes	reactome/R-HSA-977615.md	Factor I inactivates MCP/CR1-bound C4b/C3b	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CR1	genes/human/CR1/CR1-ai-review.yaml	CR1	P17927	NCBITaxon:9606	Homo sapiens	52	R-HSA-977629	Displacement of C2a/Bb by CR1	yes	reactome/R-HSA-977629.md	Displacement of C2a/Bb by CR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane/extracellular location is consistent with CR1 as a large ectodomain-containing single-pass complement receptor.
human	CRBN	genes/human/CRBN/CRBN-ai-review.yaml	CRBN	Q96SW2	NCBITaxon:9606	Homo sapiens	26	R-HSA-9681169	CRBN binds IMiDs	yes	reactome/R-HSA-9681169.md	CRBN binds IMiDs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from Reactome (CRBN binds IMiDs), consistent with the experimentally supported cytoplasm annotation.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	96	R-HSA-199298	AKT phosphorylation of CREB1	yes	reactome/R-HSA-199298.md	AKT phosphorylates CREB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for AKT phosphorylation of CREB1 places CREB1 in nucleoplasm.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	97	R-HSA-199895	RSK1/2/3 phosphorylation of CREB	yes	reactome/R-HSA-199895.md	RSK1/2/3 phosphorylates CREB at Serine 119	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RSK1/2/3 phosphorylation of CREB.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	98	R-HSA-199917	MAPKAPK2 phosphorylation of CREB	yes	reactome/R-HSA-199917.md	MAPKAPK2 phosphorylates CREB at Serine 133	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for MAPKAPK2 phosphorylation of CREB.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	99	R-HSA-199935	MSK1 activation of CREB	yes	reactome/R-HSA-199935.md	MSK1 activates CREB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for MSK1 activation of CREB.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	100	R-HSA-2399996	AKT1 E17K mutant phosphorylation of CREB1	yes	reactome/R-HSA-2399996.md	AKT1 E17K mutant phosphorylates CREB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for AKT1 E17K mutant phosphorylation of CREB1.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	101	R-HSA-442724	RSK phosphorylation of CREB1	yes	reactome/R-HSA-442724.md	Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for RSK phosphorylation of CREB1.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	102	R-HSA-9612501	SGK phosphorylation of CREB1	yes	reactome/R-HSA-9612501.md	SGK phosphorylates CREB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SGK phosphorylation of CREB1.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	103	R-HSA-9612514	p-S133 CREB binding to EGR1 promoter	yes	reactome/R-HSA-9612514.md	p-S133 CREB and p-S103 SRF bind the EGR1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for p-S133 CREB binding to EGR1 promoter.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	104	R-HSA-9613451	CREB1 binding to ID1 and ID3 genes	yes	reactome/R-HSA-9613451.md	p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB1 binding to ID1 and ID3 genes.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	105	R-HSA-9623341	CREB1 binding to CCND1 promoter	yes	reactome/R-HSA-9623341.md	p-S133 CREB1 dimer binds the CCND1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB1 binding to CCND1 promoter.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	106	R-HSA-9662708	CREB binding to IL6 promoter	yes	reactome/R-HSA-9662708.md	CREB binds IL6 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB binding to IL6 promoter.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	107	R-HSA-9664332	CREB1 binding to IL-10 promoter	yes	reactome/R-HSA-9664332.md	CREB1 binds IL-10 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB1 binding to IL-10 promoter.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	108	R-HSA-9824653	CREB1 binding to MITF promoter	yes	reactome/R-HSA-9824653.md	p-S133-CREB1 binds MITF promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB1 binding to MITF promoter.
human	CREB1	genes/human/CREB1/CREB1-ai-review.yaml	CREB1	P16220	NCBITaxon:9606	Homo sapiens	109	R-HSA-9825848	CREB1 at DCT promoter	yes	reactome/R-HSA-9825848.md	MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway for CREB1 at DCT promoter.
human	CRISP3	genes/human/CRISP3/CRISP3-ai-review.yaml	CRISP3	P54108	NCBITaxon:9606	Homo sapiens	3	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6798745 (Exocytosis of tertiary granule lumen proteins) is correct, representing the destination of CRISP3 after exocytosis from tertiary granules.
human	CRISP3	genes/human/CRISP3/CRISP3-ai-review.yaml	CRISP3	P54108	NCBITaxon:9606	Homo sapiens	4	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6798749 (Exocytosis of specific granule lumen proteins) is correct, representing the destination of CRISP3 after exocytosis from specific granules.
human	CRISP3	genes/human/CRISP3/CRISP3-ai-review.yaml	CRISP3	P54108	NCBITaxon:9606	Homo sapiens	5	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation for specific granule lumen is strongly supported by direct experimental evidence showing CRISP3 as a matrix protein within specific granules of neutrophils.
human	CRISP3	genes/human/CRISP3/CRISP3-ai-review.yaml	CRISP3	P54108	NCBITaxon:9606	Homo sapiens	6	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation for tertiary granule lumen is supported by evidence showing CRISP3 in a continuum of peroxidase-negative granules including tertiary (gelatinase) granules.
human	CRMP1	genes/human/CRMP1/CRMP1-ai-review.yaml	CRMP1	Q14194	NCBITaxon:9606	Homo sapiens	37	R-HSA-399951	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for CRMP1 (cytoplasmic/cytoskeletal CRMP).
human	CRMP1	genes/human/CRMP1/CRMP1-ai-review.yaml	CRMP1	Q14194	NCBITaxon:9606	Homo sapiens	38	R-HSA-399944	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for CRMP1 (cytoplasmic/cytoskeletal CRMP).
human	CRMP1	genes/human/CRMP1/CRMP1-ai-review.yaml	CRMP1	Q14194	NCBITaxon:9606	Homo sapiens	39	R-HSA-399947	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399947.md	Tyrosine phosphorylation of CRMPs by Fes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for CRMP1 (cytoplasmic/cytoskeletal CRMP).
human	CRTAP	genes/human/CRTAP/CRTAP-ai-review.yaml	CRTAP	O75718	NCBITaxon:9606	Homo sapiens	16	R-HSA-1980233	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	yes	reactome/R-HSA-1980233.md	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome localizes CRTAP to the ER lumen, the precise compartment where the prolyl 3-hydroxylation complex acts on procollagen. This is more specific than the generic ER term and is well supported.
human	CRTAP	genes/human/CRTAP/CRTAP-ai-review.yaml	CRTAP	O75718	NCBITaxon:9606	Homo sapiens	17	R-HSA-2022073	Procollagen triple helix formation	yes	reactome/R-HSA-2022073.md	Procollagen triple helix formation	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Redundant Reactome ER-lumen localization (procollagen triple helix formation reaction). Correct and consistent with the validated ER-luminal location.
human	CRTAP	genes/human/CRTAP/CRTAP-ai-review.yaml	CRTAP	O75718	NCBITaxon:9606	Homo sapiens	18	R-HSA-8948226	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	yes	reactome/R-HSA-8948226.md	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Redundant Reactome ER-lumen localization (prolyl 3-hydroxylase complex dissociation reaction). Correct location, consistent with the accepted ER-lumen annotation.
human	CRTAP	genes/human/CRTAP/CRTAP-ai-review.yaml	CRTAP	O75718	NCBITaxon:9606	Homo sapiens	19	R-HSA-8948230	P3HB binds 4-Hyp-collagen propeptides	yes	reactome/R-HSA-8948230.md	P3HB binds 4-Hyp-collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Redundant Reactome ER-lumen localization (P3HB binds 4-Hyp-collagen propeptides reaction). Correct location, consistent with the accepted ER-lumen annotation.
human	CRYAB	genes/human/CRYAB/CRYAB-ai-review.yaml	CRYAB	P02511	NCBITaxon:9606	Homo sapiens	87	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-5082356 (HSF1-mediated gene expression) for nucleoplasm localization. CRYAB translocates to the nucleus during heat stress (PMID:19464326) and specifically resides in SC35 speckles within the nucleoplasm.
human	CSN1S1	genes/human/CSN1S1/CSN1S1-ai-review.yaml	CSN1S1	P47710	NCBITaxon:9606	Homo sapiens	8	R-HSA-5340124	CSN polymer binds CaPO4	yes	reactome/R-HSA-5340124.md	CSN polymer binds CaPO4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region - secreted into milk.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	33	R-HSA-204005	COPII-mediated vesicle transport	yes	reactome/R-HSA-204005.md	COPII-mediated vesicle transport	Homo sapiens	GO:0048208	COPII vesicle coat assembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation linking CK1delta to COPII vesicle formation via SEC23 phosphorylation. A narrow substrate-driven role.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	34	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of protein serine/threonine kinase activity in the context of SEC23 phosphorylation. Core MF.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	64	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to the ERGIC membrane in the context of SEC23 phosphorylation during COPII vesicle formation. Plausible given the Golgi/secretory role.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	71	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (AURKA pathway reaction). Cytosol is a genuine CK1delta location; one of many redundant Reactome citations.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	72	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (AURKA pathway reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	73	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (AURKA/PLK1 reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	74	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (BORA/PLK1/AURKA reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	75	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (centrosome maturation reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	76	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (gamma-TuRC recruitment reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	77	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (centrosome reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	78	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (Nlp dissociation reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	79	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (Plk1 recruitment reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	80	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (NuMA/microtubule reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	81	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (CDK11p58 recruitment reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	82	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (NuMA translocation reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	83	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (RAB3IP/RAB8A reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	84	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (C2CD3 centriole reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	85	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (distal appendage protein reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	86	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (CP110/CEP97 dissociation reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	87	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (TTBK2 recruitment reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	88	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (transition zone protein reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	89	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (MARK4/ODF2 reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	90	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (CEP164/RAB3IP vesicle reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	91	R-HSA-6791223	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	yes	reactome/R-HSA-6791223.md	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (pre-40S rRNA processing reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	92	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (TPX2/AURKA reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	93	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (TPX2/AURKA autophosphorylation reaction). Redundant but correct CC term.
human	CSNK1D	genes/human/CSNK1D/CSNK1D-ai-review.yaml	CSNK1D	P48730	NCBITaxon:9606	Homo sapiens	101	R-HSA-6791223	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	yes	reactome/R-HSA-6791223.md	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome (pre-rRNA processing reaction); consistent with documented nuclear localization.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	61	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular localization is a bulk neutrophil-degranulation/secretome transfer from Reactome (exocytosis of secretory granule lumen proteins). CK2beta is an intracellular kinase subunit; extracellular region is not a meaningful core localization.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	62	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular region via ficolin-rich granule exocytosis (Reactome neutrophil degranulation). Bulk-secretome transfer, not core.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	63	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Secretory granule lumen from neutrophil-degranulation Reactome transfer. Not a core localization of an intracellular kinase subunit.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	64	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Ficolin-1-rich granule lumen from neutrophil-degranulation Reactome transfer. Not core.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	65	R-HSA-6805059	CK2:FACT phosphorylates TP53	yes	reactome/R-HSA-6805059.md	CK2:FACT phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm from Reactome (CK2:FACT phosphorylates TP53). Consistent with the documented nuclear localization of CK2beta.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	66	R-HSA-6805061	CK2 binds FACT	yes	reactome/R-HSA-6805061.md	CK2 binds FACT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm from Reactome (CK2 binds FACT). Consistent with nuclear localization.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	67	R-HSA-9831712	M dimer is phosphorylated	yes	reactome/R-HSA-9831712.md	M dimer is phosphorylated	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm from Reactome (M dimer phosphorylation pathway). Consistent with nuclear localization.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	72	R-HSA-201717	CSNK2-mediated phosphorylation of DVL	yes	reactome/R-HSA-201717.md	CSNK2-mediated phosphorylation of DVL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CSNK2-mediated phosphorylation of DVL, Wnt signaling). CK2 is broadly cytosolic; cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	73	R-HSA-2529020	CK2 phosphorylates condensin I subunits	yes	reactome/R-HSA-2529020.md	CK2 phosphorylates condensin I subunits	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates condensin I subunits). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	74	R-HSA-392752	Phosphorylation of L1 by CK-II	yes	reactome/R-HSA-392752.md	Phosphorylation of L1 by CK-II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (phosphorylation of L1 by CK-II). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	75	R-HSA-6814409	CK2 phosphorylates PDCL	yes	reactome/R-HSA-6814409.md	CK2 phosphorylates PDCL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates PDCL). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	76	R-HSA-8850945	Casein kinase II phosphorylates PTEN	yes	reactome/R-HSA-8850945.md	Casein kinase II phosphorylates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates PTEN). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	77	R-HSA-8873929	Casein kinase II phosphorylates STARD10	yes	reactome/R-HSA-8873929.md	Casein kinase II phosphorylates STARD10	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates STARD10). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	78	R-HSA-8948039	FUNDC1 is phosphorylated by CK2	yes	reactome/R-HSA-8948039.md	FUNDC1 is phosphorylated by CK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (FUNDC1 phosphorylation by CK2, mitophagy). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	79	R-HSA-9831514	CK2 phosphorylates nascent P	yes	reactome/R-HSA-9831514.md	CK2 phosphorylates nascent P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates nascent viral P protein). Cytosolic localization is accurate.
human	CSNK2B	genes/human/CSNK2B/CSNK2B-ai-review.yaml	CSNK2B	P67870	NCBITaxon:9606	Homo sapiens	80	R-HSA-9931418	CK2 phosphorylates CD274	yes	reactome/R-HSA-9931418.md	CK2 phosphorylates CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol from Reactome (CK2 phosphorylates CD274/PD-L1). Cytosolic localization is accurate.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	62	R-HSA-3108209	PRC1 SUMOylates CTBP1 with SUMO1	yes	reactome/R-HSA-3108209.md	PRC1 SUMOylates CTBP1 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome SUMOylation pathway. CTBP1 is SUMOylated at Lys-428 by CBX4 in the nucleus (PMID:12679040). Consistent with nuclear localization.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	63	R-HSA-3108203	PRC1 SUMOylates CTBP1 with SUMO2,3	yes	reactome/R-HSA-3108203.md	PRC1 SUMOylates CTBP1 with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Same as above. Nucleoplasm is the site of CTBP1 SUMOylation events. Consistent with established nuclear localization.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	70	R-HSA-3361751	beta-catenin is replaced by repression complexes at the promoter	yes	reactome/R-HSA-3361751.md	beta-catenin is replaced by repression complexes at the promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-3361751. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	71	R-HSA-3364042	APC promotes disassembly of beta-catenin transactivation complex	yes	reactome/R-HSA-3364042.md	APC promotes disassembly of beta-catenin transactivation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-3364042. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	72	R-HSA-5334050	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes	yes	reactome/R-HSA-5334050.md	TCF7L2/TCF7L1 bind CTBP1 to repress WNT target genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-5334050. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	73	R-HSA-5334052	TFC7L2 mutants don't bind CTBP	yes	reactome/R-HSA-5334052.md	TFC7L2 mutants don't bind CTBP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-5334052. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	74	R-HSA-9765973	CTBP1,CTBP2 binds ZEB1	yes	reactome/R-HSA-9765973.md	CTBP1,CTBP2 binds ZEB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-9765973. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	75	R-HSA-9765974	MCRIP1 binds CTBP1	yes	reactome/R-HSA-9765974.md	MCRIP1 binds CTBP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-9765974. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTBP1	genes/human/CTBP1/CTBP1-ai-review.yaml	CTBP1	Q13363	NCBITaxon:9606	Homo sapiens	76	R-HSA-9768477	CTBP1,CTBP2 binds CDH1 gene promoter	yes	reactome/R-HSA-9768477.md	CTBP1,CTBP2 binds CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway Reactome:R-HSA-9768477. CTBP1 functions in the nucleoplasm as a transcriptional corepressor in Wnt signaling and other pathways.
human	CTDSP2	genes/human/CTDSP2/CTDSP2-ai-review.yaml	CTDSP2	O14595	NCBITaxon:9606	Homo sapiens	14	R-HSA-1791130	Expression of CTDSP2	yes	reactome/R-HSA-1791130.md	Expression of CTDSP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear/nucleoplasmic localization is appropriate for the CTD phosphatase role.
human	CTH	genes/human/CTH/CTH-ai-review.yaml	CTH	P32929	NCBITaxon:9606	Homo sapiens	24	R-HSA-1614567	Excess homocysteine yields homolanthionine and H2S	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing CTH to the cytosol in the reaction 'Excess homocysteine yields homolanthionine and H2S'.
human	CTH	genes/human/CTH/CTH-ai-review.yaml	CTH	P32929	NCBITaxon:9606	Homo sapiens	25	R-HSA-1614583	PXLP-K212-CTH cleaves L-Cystathionine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing CTH to the cytosol for the reaction 'PXLP-K212-CTH cleaves L-Cystathionine' (the canonical cystathionine gamma-lyase step, showing PLP at Lys212).
human	CTH	genes/human/CTH/CTH-ai-review.yaml	CTH	P32929	NCBITaxon:9606	Homo sapiens	26	R-HSA-1614591	Excess cysteine yields lanthionine and H2S	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing CTH to the cytosol for the reaction 'Excess cysteine yields lanthionine and H2S'.
human	CTH	genes/human/CTH/CTH-ai-review.yaml	CTH	P32929	NCBITaxon:9606	Homo sapiens	27	R-HSA-1614614	Cysteine is degraded to pyruvate and H2S	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing CTH to the cytosol for the reaction 'Cysteine is degraded to pyruvate and H2S'.
human	CTH	genes/human/CTH/CTH-ai-review.yaml	CTH	P32929	NCBITaxon:9606	Homo sapiens	28	R-HSA-1614631	Homocysteine is degraded to oxobutanoate and H2S	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing CTH to the cytosol for the reaction 'Homocysteine is degraded to oxobutanoate and H2S'.
human	CTLA4	genes/human/CTLA4/CTLA4-ai-review.yaml	CTLA4	P16410	NCBITaxon:9606	Homo sapiens	34	R-HSA-388829	SHP2 phosphatase binds CTLA-4	yes	reactome/R-HSA-388829.md	SHP2 phosphatase binds CTLA-4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome pathway ""SHP2 phosphatase binds CTLA-4"" (R-HSA-388829). CTLA4 is at the plasma membrane where SHP-2 binds to its cytoplasmic tail. Well-supported."
human	CTLA4	genes/human/CTLA4/CTLA4-ai-review.yaml	CTLA4	P16410	NCBITaxon:9606	Homo sapiens	35	R-HSA-388833	Phosphorylation of CTLA-4	yes	reactome/R-HSA-388833.md	Phosphorylation of CTLA-4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome pathway ""Phosphorylation of CTLA-4"" (R-HSA-388833). CTLA4 is phosphorylated at the plasma membrane."
human	CTLA4	genes/human/CTLA4/CTLA4-ai-review.yaml	CTLA4	P16410	NCBITaxon:9606	Homo sapiens	38	R-HSA-388809	CTLA-4 binds B7-1/B7-2	yes	reactome/R-HSA-388809.md	CTLA-4 binds B7-1/B7-2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome pathway ""CTLA-4 binds B7-1/B7-2"" (R-HSA-388809). CTLA4 binds B7 ligands at the plasma membrane."
human	CTLA4	genes/human/CTLA4/CTLA4-ai-review.yaml	CTLA4	P16410	NCBITaxon:9606	Homo sapiens	39	R-HSA-389532	PP2A binds CTLA4 dimer	yes	reactome/R-HSA-389532.md	PP2A binds CTLA4 dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome pathway ""PP2A binds CTLA4 dimer"" (R-HSA-389532). PP2A interacts with CTLA4 at the plasma membrane."
human	CTLA4	genes/human/CTLA4/CTLA4-ai-review.yaml	CTLA4	P16410	NCBITaxon:9606	Homo sapiens	40	R-HSA-8877421	CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1	yes	reactome/R-HSA-8877421.md	CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome pathway ""CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1"" (R-HSA-8877421). This Reactome entry describes transcriptional regulation of CTLA4 by FOXP3 in Tregs."
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	12	R-HSA-9758881	Uptake of dietary cobalamins into enterocytes	yes	reactome/R-HSA-9758881.md	Uptake of dietary cobalamins into enterocytes	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS annotation for cobalamin transport (""Uptake of dietary cobalamins into enterocytes""). This is a core biological process for cubilin, which as part of cubam mediates intestinal uptake of IF-bound B12."
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	13	R-HSA-196791	Vitamin D (calciferol) metabolism	yes	reactome/R-HSA-196791.md	Vitamin D (calciferol) metabolism	Homo sapiens	GO:0042359	vitamin D metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation for vitamin D metabolic process. Cubilin, with megalin, reabsorbs vitamin-D-binding protein (GC) carrying 25(OH)D from the glomerular filtrate, contributing to vitamin D handling. This is a physiologically relevant but non-core role.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	14	R-HSA-350186	CUBN binds GC:25(OH)D	yes	reactome/R-HSA-350186.md	CUBN binds GC:25(OH)D	Homo sapiens	GO:0038024	cargo receptor activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS annotation for cargo receptor activity (""CUBN binds GC:25(OH)D""). This is the core molecular function of cubilin - a non-enzymatic multiligand cargo/endocytic receptor."
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	46	R-HSA-3296462	Defective CUBN does not transport GIF:Cbl	yes	reactome/R-HSA-3296462.md	Defective CUBN does not transport GIF:Cbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (from a defective-CUBN transport reaction). Correct high-level location subsumed by the apical plasma membrane annotations.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	47	R-HSA-209760	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen	yes	reactome/R-HSA-209760.md	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to cytosol, arising from Reactome pathway modeling of endocytic translocation reactions. Cubilin is a peripheral, extracellular-facing membrane protein without a cytoplasmic domain, so a cytosolic localization is biologically implausible and likely an artifact of pathway-reaction compartment assignment.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	48	R-HSA-350168	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	yes	reactome/R-HSA-350168.md	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to cytosol (from the LRP2-mediated uptake reaction). As above, cubilin is an extracellular-facing peripheral membrane protein, so cytosolic localization is an artifact of Reactome reaction compartments.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	49	R-HSA-209760	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen	yes	reactome/R-HSA-209760.md	Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to lysosomal lumen, from the pathway modeling of endocytic delivery of the CUBN:GC:25(OH)D complex to the lysosome. Reflects trafficking of endocytosed cargo to lysosomes; a downstream, non-core location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	50	R-HSA-350158	LGMN hydrolyzes GC, releasing CUBN and 25(OH)D	yes	reactome/R-HSA-350158.md	LGMN hydrolyzes GC, releasing CUBN and 25(OH)D	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to lysosomal lumen (LGMN-mediated release of CUBN and 25(OH)D). Downstream lysosomal delivery of endocytosed cargo; non-core location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	51	R-HSA-264834	Endocytosis and degradation of apoA-I	yes	reactome/R-HSA-264834.md	Endocytosis and degradation of apoA-I	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (endocytosis/degradation of apoA-I reaction). Correct broad cell-surface location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	52	R-HSA-264848	apoA-I binds to CUBN:AMN	yes	reactome/R-HSA-264848.md	apoA-I binds to CUBN:AMN	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (apoA-I binds CUBN:AMN reaction). Correct broad cell-surface location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	53	R-HSA-3000103	CUBN:AMN binds CBLIF:RCbl	yes	reactome/R-HSA-3000103.md	CUBN:AMN binds CBLIF:RCbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (CUBN:AMN binds CBLIF:RCbl reaction). Correct broad cell-surface location where IF-cobalamin is captured.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	54	R-HSA-3000137	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000137.md	CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (CUBN:AMN-mediated CBLIF:RCbl uptake reaction). Correct broad cell-surface location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	55	R-HSA-3296477	Defective AMN does not transport GIF:Cbl	yes	reactome/R-HSA-3296477.md	Defective AMN does not transport GIF:Cbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (defective-AMN transport reaction). Correct broad cell-surface location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	56	R-HSA-350168	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	yes	reactome/R-HSA-350168.md	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D reaction). Correct broad cell-surface location.
human	CUBN	genes/human/CUBN/CUBN-ai-review.yaml	CUBN	O60494	NCBITaxon:9606	Homo sapiens	57	R-HSA-350186	CUBN binds GC:25(OH)D	yes	reactome/R-HSA-350186.md	CUBN binds GC:25(OH)D	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to plasma membrane (CUBN binds GC:25(OH)D reaction). Correct broad cell-surface location.
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	146	R-HSA-1363328	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-1363328.md	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	147	R-HSA-1363331	Ubiquitination of p130 (RBL2) by SCF (Skp2)	yes	reactome/R-HSA-1363331.md	Ubiquitination of p130 (RBL2) by SCF (Skp2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Ubiquitination of p130 (RBL2) by SCF (Skp2)""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	148	R-HSA-187545	Association of Cks1 with SCF(Skp2) complex	yes	reactome/R-HSA-187545.md	Association of Cks1 with SCF(Skp2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Association of Cks1 with SCF(Skp2) complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	149	R-HSA-187552	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	150	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Degradation of ubiquitinated p27/p21 by the 26S proteasome""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	151	R-HSA-187575	Ubiquitination of phospho-p27/p21	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Ubiquitination of phospho-p27/p21""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	152	R-HSA-2220967	p-NICD1 PEST domain mutants do not bind FBXW7	yes	reactome/R-HSA-2220967.md	p-NICD1 PEST domain mutants do not bind FBXW7	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""p-NICD1 PEST domain mutants do not bind FBXW7""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	153	R-HSA-2220978	FBXW7 WD mutants do not bind NICD1	yes	reactome/R-HSA-2220978.md	FBXW7 WD mutants do not bind NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""FBXW7 WD mutants do not bind NICD1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	154	R-HSA-68946	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	yes	reactome/R-HSA-68946.md	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Phosphorylated Orc1 is ubiquitinated while still associated with chromatin""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	155	R-HSA-69598	Ubiquitination of phosphorylated CDC25A	yes	reactome/R-HSA-69598.md	Ubiquitination of phosphorylated CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Ubiquitination of phosphorylated CDC25A""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	156	R-HSA-8939688	SCF(SKP2) complex binds RUNX2	yes	reactome/R-HSA-8939688.md	SCF(SKP2) complex binds RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""SCF(SKP2) complex binds RUNX2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	157	R-HSA-8939706	SCF(SKP2) polyubiquitinates RUNX2	yes	reactome/R-HSA-8939706.md	SCF(SKP2) polyubiquitinates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""SCF(SKP2) polyubiquitinates RUNX2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	158	R-HSA-9708517	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	yes	reactome/R-HSA-9708517.md	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	159	R-HSA-9708525	BACH1:FBXL17 binds SCF(SKP2) complex	yes	reactome/R-HSA-9708525.md	BACH1:FBXL17 binds SCF(SKP2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""BACH1:FBXL17 binds SCF(SKP2) complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	160	R-HSA-9725023	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	yes	reactome/R-HSA-9725023.md	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	161	R-HSA-9725030	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	yes	reactome/R-HSA-9725030.md	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	162	R-HSA-9762091	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	yes	reactome/R-HSA-9762091.md	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	163	R-HSA-9762093	BTRC binds p-S344, 347 NFE2L2	yes	reactome/R-HSA-9762093.md	BTRC binds p-S344, 347 NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""BTRC binds p-S344, 347 NFE2L2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	164	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""Ub,pS335,S338,T NFE2L2 is degraded""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	165	R-NUL-2064853	FBXW7 binds phosphorylated NICD1	yes	reactome/R-NUL-2064853.md	FBXW7 binds phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""FBXW7 binds phosphorylated NICD1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	166	R-NUL-2064883	FBXW7 mediates ubiquitination of phosphorylated NICD1	yes	reactome/R-NUL-2064883.md	FBXW7 mediates ubiquitination of phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""FBXW7 mediates ubiquitination of phosphorylated NICD1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	167	R-NUL-9604628	FBXW7 promotes ubiquitination of mouse p-NICD4	yes	reactome/R-NUL-9604628.md	FBXW7 promotes ubiquitination of mouse p-NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SCF in the Reactome reaction ""FBXW7 promotes ubiquitination of mouse p-NICD4""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	170	R-HSA-1168642	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB	yes	reactome/R-HSA-1168642.md	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	171	R-HSA-1168643	SCF-beta-TrCP ubiquitinylates IkB	yes	reactome/R-HSA-1168643.md	SCF-beta-TrCP ubiquitinylates IkB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-beta-TrCP ubiquitinylates IkB""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	172	R-HSA-1170539	Prolactin receptor is internalized	yes	reactome/R-HSA-1170539.md	Prolactin receptor is internalized	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Prolactin receptor is internalized""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	173	R-HSA-1370500	PRLR binds SCF beta-TrCP complex	yes	reactome/R-HSA-1370500.md	PRLR binds SCF beta-TrCP complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""PRLR binds SCF beta-TrCP complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	174	R-HSA-174159	Ubiquitination of Emi1 by SCF-beta-TrCP	yes	reactome/R-HSA-174159.md	Ubiquitination of Emi1 by SCF-beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Ubiquitination of Emi1 by SCF-beta-TrCP""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	175	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-mediated degradation of Emi1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	176	R-HSA-174209	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	yes	reactome/R-HSA-174209.md	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Phosphorylated Emi1 binds the beta-TrCP in the SCF complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	177	R-HSA-209063	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	yes	reactome/R-HSA-209063.md	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	178	R-HSA-209125	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	yes	reactome/R-HSA-209125.md	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""'SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex'""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	179	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	180	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Degradation of ubiquitinated beta catenin by the proteasome""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	181	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	182	R-HSA-3000335	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA	yes	reactome/R-HSA-3000335.md	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	183	R-HSA-3000339	Phosphorylated BORA binds SCF-beta-TrCp1/2	yes	reactome/R-HSA-3000339.md	Phosphorylated BORA binds SCF-beta-TrCp1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Phosphorylated BORA binds SCF-beta-TrCp1/2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	184	R-HSA-5607723	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB	yes	reactome/R-HSA-5607723.md	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	185	R-HSA-5607725	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP	yes	reactome/R-HSA-5607725.md	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	186	R-HSA-5607728	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex	yes	reactome/R-HSA-5607728.md	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	187	R-HSA-5610742	SCF(beta-TrCP) ubiquitinates p-GLI1	yes	reactome/R-HSA-5610742.md	SCF(beta-TrCP) ubiquitinates p-GLI1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF(beta-TrCP) ubiquitinates p-GLI1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	188	R-HSA-5610746	SCF(beta-TrCP) ubiquitinates p-GLI3	yes	reactome/R-HSA-5610746.md	SCF(beta-TrCP) ubiquitinates p-GLI3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF(beta-TrCP) ubiquitinates p-GLI3""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	189	R-HSA-5684248	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2	yes	reactome/R-HSA-5684248.md	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	190	R-HSA-5684250	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2	yes	reactome/R-HSA-5684250.md	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""'SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 '""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	191	R-HSA-5691108	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	yes	reactome/R-HSA-5691108.md	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	192	R-HSA-5691131	CANDI binds CUL1	yes	reactome/R-HSA-5691131.md	CANDI binds CUL1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""CANDI binds CUL1""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	193	R-HSA-5691167	CUL1, SKP1, FBXL5 bind	yes	reactome/R-HSA-5691167.md	CUL1, SKP1, FBXL5 bind	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""CUL1, SKP1, FBXL5 bind""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	194	R-HSA-5691176	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	yes	reactome/R-HSA-5691176.md	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	195	R-HSA-8853496	SCF:FBXL7 binds AURKA	yes	reactome/R-HSA-8853496.md	SCF:FBXL7 binds AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF:FBXL7 binds AURKA""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	196	R-HSA-8854041	SCF-FBXL7 ubiquitinates AURKA	yes	reactome/R-HSA-8854041.md	SCF-FBXL7 ubiquitinates AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-FBXL7 ubiquitinates AURKA""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	197	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Proteasome degrades AURKA ubiquitinated by SCF-FBXL7""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	198	R-HSA-8854051	SCF-FBXL18 ubiquitinates FBXL7	yes	reactome/R-HSA-8854051.md	SCF-FBXL18 ubiquitinates FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""SCF-FBXL18 ubiquitinates FBXL7""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	199	R-HSA-8854052	Formation of the SCF-FBXL7 complex	yes	reactome/R-HSA-8854052.md	Formation of the SCF-FBXL7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Formation of the SCF-FBXL7 complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	200	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	201	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	202	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""CAND1 binds cytosolic CRL E3 ubiquitin ligases""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	203	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	204	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	205	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	206	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Transfer of Ub from E2 to substrate and release of E2""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	207	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Release of E3 from polyubiquitinated substrate""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	208	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Polyubiquitination of substrate""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	209	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Interaction of E3 with substrate and E2-Ub complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	210	R-HSA-9929350	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	yes	reactome/R-HSA-9929350.md	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Ubiquitination of CD274 by BTRC-SCF E3-ligase complex""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	211	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Ubiquitinated CD274 is degraded by the 26S proteasome""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	212	R-HSA-9929353	Deubiquitination of CD274	yes	reactome/R-HSA-9929353.md	Deubiquitination of CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""Deubiquitination of CD274""."
human	CUL1	genes/human/CUL1/CUL1-ai-review.yaml	CUL1	Q13616	NCBITaxon:9606	Homo sapiens	213	R-HSA-9929357	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	yes	reactome/R-HSA-9929357.md	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic CUL1/SCF in the Reactome reaction ""p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex""."
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	142	R-HSA-8932327	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	yes	reactome/R-HSA-8932327.md	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 can be represented in cytosolic CRL3 pathway contexts.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	143	R-HSA-8952631	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952631.md	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	144	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	145	R-HSA-9712274	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	yes	reactome/R-HSA-9712274.md	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	146	R-HSA-9755505	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	yes	reactome/R-HSA-9755505.md	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	147	R-HSA-9755507	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	148	R-HSA-9758090	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	149	R-HSA-9759169	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	yes	reactome/R-HSA-9759169.md	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	150	R-HSA-9759172	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	yes	reactome/R-HSA-9759172.md	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	151	R-HSA-9766645	CUL3:RBX1 ubiquitinates KEAP1	yes	reactome/R-HSA-9766645.md	CUL3:RBX1 ubiquitinates KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	152	R-HSA-9766656	RBX1:CUL3 dissociates from forming autophagosome	yes	reactome/R-HSA-9766656.md	RBX1:CUL3 dissociates from forming autophagosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	153	R-HSA-9766677	MAP1LC3B binds KEAP1 and SQSTM1	yes	reactome/R-HSA-9766677.md	MAP1LC3B binds KEAP1 and SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	154	R-HSA-9766687	SESN1,SESN1 bind SQSTM1 and KEAP1	yes	reactome/R-HSA-9766687.md	SESN1,SESN1 bind SQSTM1 and KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	164	R-HSA-5635854	GLI2,3 are degraded by the proteasome	yes	reactome/R-HSA-5635854.md	GLI2,3 are degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as nucleoplasmic in Reactome GLI/Hedgehog CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	165	R-HSA-5635855	phosphorylated GLI proteins bind SPOP:CUL3:RBX1	yes	reactome/R-HSA-5635855.md	phosphorylated GLI proteins bind SPOP:CUL3:RBX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as nucleoplasmic in Reactome GLI/Hedgehog CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	166	R-HSA-5635856	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	yes	reactome/R-HSA-5635856.md	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as nucleoplasmic in Reactome GLI/Hedgehog CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	178	R-HSA-1504190	DVL is ubiquitinated by CUL3:KLHL12:RBX1	yes	reactome/R-HSA-1504190.md	DVL is ubiquitinated by CUL3:KLHL12:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 can be represented in cytosolic CRL3 pathway contexts.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	179	R-HSA-1504193	Ubiquitinated DVL is degraded by the proteasome	yes	reactome/R-HSA-1504193.md	Ubiquitinated DVL is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	180	R-HSA-1504213	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex	yes	reactome/R-HSA-1504213.md	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	181	R-HSA-5658424	KBTBD7:CUL3:RBX1 ubiquitinates NF1	yes	reactome/R-HSA-5658424.md	KBTBD7:CUL3:RBX1 ubiquitinates NF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	182	R-HSA-8952630	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952630.md	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	183	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	184	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	185	R-HSA-9018778	RHOBTB1 binds interacting proteins at the endosome membrane	yes	reactome/R-HSA-9018778.md	RHOBTB1 binds interacting proteins at the endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	186	R-HSA-9018787	RHOBTB2 binds interacting proteins at the endosome membrane	yes	reactome/R-HSA-9018787.md	RHOBTB2 binds interacting proteins at the endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	187	R-HSA-9706390	RHOBTB3 binds interacting proteins at trans-Golgi network	yes	reactome/R-HSA-9706390.md	RHOBTB3 binds interacting proteins at trans-Golgi network	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	188	R-HSA-9929484	SPOP:CUL3:RBX1 binds to CD274	yes	reactome/R-HSA-9929484.md	SPOP:CUL3:RBX1 binds to CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	189	R-HSA-9929486	SPOP-mediated degradation of CD274 by 26S Proteosome	yes	reactome/R-HSA-9929486.md	SPOP-mediated degradation of CD274 by 26S Proteosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CUL3	genes/human/CUL3/CUL3-ai-review.yaml	CUL3	Q13618	NCBITaxon:9606	Homo sapiens	190	R-HSA-9929490	CD274 ubiquitination by SPOP:CUL3:RBX1 complex	yes	reactome/R-HSA-9929490.md	CD274 ubiquitination by SPOP:CUL3:RBX1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CUL3 is represented as cytosolic in Reactome CRL3 pathway reactions.
human	CWC27	genes/human/CWC27/CWC27-ai-review.yaml	CWC27	Q6UX04	NCBITaxon:9606	Homo sapiens	12	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome, Formation of the Spliceosomal B* complex) localizing CWC27 to the nucleoplasm.
human	CWC27	genes/human/CWC27/CWC27-ai-review.yaml	CWC27	Q6UX04	NCBITaxon:9606	Homo sapiens	13	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome, Formation of the Spliceosomal Bact complex) localizing CWC27 to the nucleoplasm.
human	CWC27	genes/human/CWC27/CWC27-ai-review.yaml	CWC27	Q6UX04	NCBITaxon:9606	Homo sapiens	14	R-HSA-9921507	NS5 interacts with Spliceosome	yes	reactome/R-HSA-9921507.md	NS5 interacts with Spliceosome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome, NS5 interacts with Spliceosome) localizing CWC27 to the nucleoplasm.
human	CXCR3	genes/human/CXCR3/CXCR3-ai-review.yaml	CXCR3	P49682	NCBITaxon:9606	Homo sapiens	18	R-HSA-374248	Receptor CXCR3 binds ligands CXCL9 to 11	yes	reactome/R-HSA-374248.md	Receptor CXCR3 binds ligands CXCL9 to 11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: CXCR3 ligand binding and receptor signaling recruit immune cells. The human receptor/isoform experiments support this membrane chemokine-receptor function; calcium signaling and chemotaxis are mechanistic components rather than unrelated downstream associations.
human	CXCR3	genes/human/CXCR3/CXCR3-ai-review.yaml	CXCR3	P49682	NCBITaxon:9606	Homo sapiens	19	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: CXCR3 ligand binding and receptor signaling recruit immune cells. The human receptor/isoform experiments support this membrane chemokine-receptor function; calcium signaling and chemotaxis are mechanistic components rather than unrelated downstream associations.
human	CXCR3	genes/human/CXCR3/CXCR3-ai-review.yaml	CXCR3	P49682	NCBITaxon:9606	Homo sapiens	20	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: CXCR3 ligand binding and receptor signaling recruit immune cells. The human receptor/isoform experiments support this membrane chemokine-receptor function; calcium signaling and chemotaxis are mechanistic components rather than unrelated downstream associations.
human	CXCR3	genes/human/CXCR3/CXCR3-ai-review.yaml	CXCR3	P49682	NCBITaxon:9606	Homo sapiens	21	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: CXCR3 ligand binding and receptor signaling recruit immune cells. The human receptor/isoform experiments support this membrane chemokine-receptor function; calcium signaling and chemotaxis are mechanistic components rather than unrelated downstream associations.
human	CYB5R4	genes/human/CYB5R4/CYB5R4-ai-review.yaml	CYB5R4	Q7L1T6	NCBITaxon:9606	Homo sapiens	11	R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	yes	reactome/R-HSA-1237044.md	Erythrocytes take up carbon dioxide and release oxygen	Homo sapiens	GO:0015701	bicarbonate transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Reactome pathway-context annotation (""Erythrocytes take up carbon dioxide and release oxygen""). CYB5R4 is a redox enzyme, not a bicarbonate transporter; this is a pathway-membership artifact rather than a true molecular role."
human	CYB5R4	genes/human/CYB5R4/CYB5R4-ai-review.yaml	CYB5R4	Q7L1T6	NCBITaxon:9606	Homo sapiens	12	R-HSA-6806831	CYB5Rs reduce MetHb to HbA	yes	reactome/R-HSA-6806831.md	CYB5Rs reduce MetHb to HbA	Homo sapiens	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation of the core cytochrome-b5 reductase activity (in the context of methemoglobin reduction), consistent with experimental data.
human	CYB5R4	genes/human/CYB5R4/CYB5R4-ai-review.yaml	CYB5R4	Q7L1T6	NCBITaxon:9606	Homo sapiens	14	R-HSA-6806831	CYB5Rs reduce MetHb to HbA	yes	reactome/R-HSA-6806831.md	CYB5Rs reduce MetHb to HbA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome annotation to ER membrane. NCB5OR is explicitly a soluble protein lacking a membrane anchor, so an ER membrane localization is not accurate; it is associated with the ER but as a soluble protein.
human	CYC1	genes/human/CYC1/CYC1-ai-review.yaml	CYC1	P08574	NCBITaxon:9606	Homo sapiens	25	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS for the human ""Electron transfer from ubiquinol to cytochrome c of complex III"" reaction places CYC1 at the inner mitochondrial membrane. Core localization."
human	CYC1	genes/human/CYC1/CYC1-ai-review.yaml	CYC1	P08574	NCBITaxon:9606	Homo sapiens	26	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the UQCRFS1 maturation pathway (peptidase cleavage of the UQCRFS1 N-terminal fragment) places CYC1 at the IMM as part of the maturing Complex III. Consistent core localization.
human	CYC1	genes/human/CYC1/CYC1-ai-review.yaml	CYC1	P08574	NCBITaxon:9606	Homo sapiens	27	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the TTC19-mediated clearance of UQCRFS1 fragments from Complex III. Places CYC1 at the IMM as part of Complex III. Core localization.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	24	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-163214 (Electron transfer from reduced cytochrome c to molecular oxygen). Cytochrome c is associated with the inner mitochondrial membrane in the intermembrane space, where it interacts with Complex III and Complex IV embedded in the inner membrane. However, cytochrome c is a soluble protein of the IMS, not an integral or peripheral inner membrane protein. GO:0005758 (mitochondrial intermembrane space) is more accurate than GO:0005743. That said, UniProt notes cytochrome c is ""Loosely associated with the inner membrane"" via electrostatic and cardiolipin interactions, so this annotation is not entirely wrong."
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	25	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-164651 (Electron transfer from ubiquinol to cytochrome c of complex III). Same reasoning as above -- cytochrome c is loosely associated with the inner membrane during electron transfer.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	26	R-HSA-3341294	Superoxide reduces cytochrome c	yes	reactome/R-HSA-3341294.md	Superoxide reduces cytochrome c	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3341294 (Superoxide reduces cytochrome c). This reaction occurs in the IMS at the inner membrane surface. Same reasoning as above.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	27	R-HSA-9866217	HCCS inserts heme into cytochrome c	yes	reactome/R-HSA-9866217.md	HCCS inserts heme into cytochrome c	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9866217 (HCCS inserts heme into cytochrome c). HCCS is the holocytochrome c synthase that catalyzes heme attachment to apocytochrome c at the inner membrane. The heme insertion occurs at or near the inner membrane in the IMS.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	32	R-HSA-5688294	SIRT5 deacetylates Cytochrome C	yes	reactome/R-HSA-5688294.md	SIRT5 deacetylates Cytochrome C	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5688294 (SIRT5 deacetylates Cytochrome C). This places cytochrome c in the IMS where SIRT5 deacetylation occurs. Correct localization.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	36	R-HSA-114284	Release of Cytochrome c from mitochondria	yes	reactome/R-HSA-114284.md	Release of Cytochrome c from mitochondria	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114284 (Release of Cytochrome c from mitochondria). This Reactome entry describes the release of cytochrome c from the IMS during apoptosis. Correct localization for the starting point of the apoptotic release event.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	37	R-HSA-114252	Cleavage of Procaspase-3 by the apoptosome	yes	reactome/R-HSA-114252.md	Cleavage of Procaspase-3 by the apoptosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114252 (Cleavage of Procaspase-3 by the apoptosome). Cytochrome c is in the cytosol as part of the apoptosome during caspase-3 activation. Correct condition-specific localization during apoptosis.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	38	R-HSA-114254	CYCS binds to APAF1	yes	reactome/R-HSA-114254.md	CYCS binds to APAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114254 (CYCS binds to APAF1). Cytochrome c binds Apaf-1 in the cytosol to initiate apoptosome formation. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	39	R-HSA-114256	CYCS:APAF1 binds procaspase-9	yes	reactome/R-HSA-114256.md	CYCS:APAF1 binds procaspase-9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114256 (CYCS:APAF1 binds procaspase-9). Apoptosome formation in the cytosol. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	40	R-HSA-114259	Cleavage of Procaspase-9 to caspase-9	yes	reactome/R-HSA-114259.md	Cleavage of Procaspase‑9 to caspase‑9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114259 (Cleavage of Procaspase-9 to caspase-9). Caspase-9 activation within the cytosolic apoptosome. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	41	R-HSA-114261	Cleavage of Procaspase-7 by the apoptosome	yes	reactome/R-HSA-114261.md	Cleavage of Procaspase-7 by the apoptosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114261 (Cleavage of Procaspase-7 by the apoptosome). Apoptosome function in the cytosol. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	42	R-HSA-114284	Release of Cytochrome c from mitochondria	yes	reactome/R-HSA-114284.md	Release of Cytochrome c from mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-114284 (Release of Cytochrome c from mitochondria). This is the same Reactome entry used for the IMS annotation above. The cytosol annotation reflects where cytochrome c ends up after release. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	43	R-HSA-1592231	Expression of CYCS	yes	reactome/R-HSA-1592231.md	Expression of CYCS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-1592231 (Expression of CYCS). Cytochrome c is synthesized in the cytosol before import into mitochondria. Correct in the context of protein synthesis, though the functional localization is the IMS.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	44	R-HSA-6804596	APAF1:CYCS binds APIP	yes	reactome/R-HSA-6804596.md	APAF1:CYCS binds APIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-6804596 (APAF1:CYCS binds APIP). Describes APIP binding to the Apaf-1:cytochrome c complex in the cytosol. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	45	R-HSA-9627056	Procaspase 9 forms dimer	yes	reactome/R-HSA-9627056.md	Procaspase 9 forms dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9627056 (Procaspase 9 forms dimer). Dimerization of procaspase-9 in the cytosol within the apoptosome context. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	46	R-HSA-9627078	XIAP binds CASP9	yes	reactome/R-HSA-9627078.md	XIAP binds CASP9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9627078 (XIAP binds CASP9). Regulation of caspase-9 by XIAP in the cytosol. Correct.
human	CYCS	genes/human/CYCS/CYCS-ai-review.yaml	CYCS	P99999	NCBITaxon:9606	Homo sapiens	47	R-HSA-9627089	CASP9 is phosphorylated at T412	yes	reactome/R-HSA-9627089.md	CASP9 is phosphorylated at T412	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9627089 (CASP9 is phosphorylated at T412). Post-translational modification of caspase-9 in the cytosol. Correct.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	21	R-HSA-196108	Pregnenolone biosynthesis	yes	reactome/R-HSA-196108.md	Pregnenolone biosynthesis	Homo sapiens	GO:0006700	C21-steroid hormone biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation (Pregnenolone biosynthesis) to C21-steroid hormone biosynthesis, consistent with the well-supported core biological process.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	22	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation (Endogenous sterols) to sterol metabolic process. Correct broad parent capturing the enzyme's role in cholesterol/sterol homeostasis.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	25	R-HSA-193054	Oxidation of cholesterol to 22beta-hydroxycholesterol	yes	reactome/R-HSA-193054.md	Oxidation of cholesterol to 22beta-hydroxycholesterol	Homo sapiens	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation for the first hydroxylation step (cholesterol to 22beta-hydroxycholesterol) catalyzed by CYP11A1, supporting the core cholesterol side-chain-cleaving activity.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	26	R-HSA-193065	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol	yes	reactome/R-HSA-193065.md	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol	Homo sapiens	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation for the second hydroxylation step (22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol) catalyzed by CYP11A1.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	27	R-HSA-193101	CYP11A1 cleaves 20a,22b-DHCHOL	yes	reactome/R-HSA-193101.md	CYP11A1 cleaves 20a,22b-DHCHOL	Homo sapiens	GO:0008386	cholesterol monooxygenase (side-chain-cleaving) activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation for the final C20-C22 bond cleavage step (20alpha,22beta-dihydroxycholesterol to pregnenolone) catalyzed by CYP11A1.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	30	R-HSA-5580269	Defective CYP11A1 does not cleave 20a,22b-DHCHOL	yes	reactome/R-HSA-5580269.md	Defective CYP11A1 does not cleave 20a,22b-DHCHOL	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the mitochondrial matrix. CYP11A1 is a peripheral membrane protein on the matrix-facing side of the inner membrane, and its product pregnenolone is released into the matrix.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	31	R-HSA-193054	Oxidation of cholesterol to 22beta-hydroxycholesterol	yes	reactome/R-HSA-193054.md	Oxidation of cholesterol to 22beta-hydroxycholesterol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the mitochondrial matrix, associated with the first side-chain cleavage reaction.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	32	R-HSA-193065	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol	yes	reactome/R-HSA-193065.md	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the mitochondrial matrix, associated with the second side-chain cleavage reaction.
human	CYP11A1	genes/human/CYP11A1/CYP11A1-ai-review.yaml	CYP11A1	P05108	NCBITaxon:9606	Homo sapiens	33	R-HSA-193101	CYP11A1 cleaves 20a,22b-DHCHOL	yes	reactome/R-HSA-193101.md	CYP11A1 cleaves 20a,22b-DHCHOL	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to the mitochondrial matrix, associated with the final C-C cleavage step; the product pregnenolone is released into the matrix.
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	18	R-HSA-194002	Glucocorticoid biosynthesis	yes	reactome/R-HSA-194002.md	Glucocorticoid biosynthesis	Homo sapiens	GO:0006704	glucocorticoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation from the Glucocorticoid biosynthesis pathway, in which CYP11B1 converts 11-deoxycortisol to cortisol.
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	19	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation from the ""Endogenous sterols"" pathway, a broad grouping of CYP-mediated steroidogenic/sterol reactions."
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	21	R-HSA-193997	CYP11B1 oxidises 11DCORT	yes	reactome/R-HSA-193997.md	CYP11B1 oxidises 11DCORT	Homo sapiens	GO:0004507	steroid 11-beta-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) annotation from the reaction ""CYP11B1 oxidises 11DCORT"" (11-deoxycortisol to cortisol), the core catalytic activity."
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	22	R-HSA-5580292	Defective CYP11B1 does not oxidise 11DCORT	yes	reactome/R-HSA-5580292.md	Defective CYP11B1 does not oxidise 11DCORT	Homo sapiens	GO:0004507	steroid 11-beta-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) annotation from the disease reaction ""Defective CYP11B1 does not oxidise 11DCORT"", capturing the same 11beta-hydroxylase molecular function in the context of AH4."
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	27	R-HSA-5580292	Defective CYP11B1 does not oxidise 11DCORT	yes	reactome/R-HSA-5580292.md	Defective CYP11B1 does not oxidise 11DCORT	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation placing CYP11B1 at the mitochondrial inner membrane, matching the curated location.
human	CYP11B1	genes/human/CYP11B1/CYP11B1-ai-review.yaml	CYP11B1	P15538	NCBITaxon:9606	Homo sapiens	46	R-HSA-193997	CYP11B1 oxidises 11DCORT	yes	reactome/R-HSA-193997.md	CYP11B1 oxidises 11DCORT	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation placing CYP11B1 at the mitochondrial inner membrane in the ""CYP11B1 oxidises 11DCORT"" reaction."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	19	R-HSA-193993	Mineralocorticoid biosynthesis	yes	reactome/R-HSA-193993.md	Mineralocorticoid biosynthesis	Homo sapiens	GO:0006705	mineralocorticoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS to mineralocorticoid biosynthetic process. Aldosterone is the major human mineralocorticoid, synthesized from deoxycorticosterone in a three-reaction sequence catalyzed by CYP11B2.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	20	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Reactome ""Endogenous sterols"" TAS grouping many CYPs under sterol metabolism. CYP11B2 acts on corticosteroids rather than free sterols; the grouping is over-broad for this specific enzyme."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	21	R-HSA-194017	CYP11B2 oxidises 11DCORST to CORST	yes	reactome/R-HSA-194017.md	CYP11B2 oxidises 11DCORST to CORST	Homo sapiens	GO:0004507	steroid 11-beta-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the reaction ""CYP11B2 oxidises 11DCORST to CORST"" - 11-beta-hydroxylation of 11-deoxycorticosterone to corticosterone."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	22	R-HSA-5600598	Defective CYP11B2 does not oxidise 11DCORST	yes	reactome/R-HSA-5600598.md	Defective CYP11B2 does not oxidise 11DCORST	Homo sapiens	GO:0004507	steroid 11-beta-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS (disease reaction ""Defective CYP11B2 does not oxidise 11DCORST"") annotating the normal 11-beta-monooxygenase activity of CYP11B2."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	25	R-HSA-5600598	Defective CYP11B2 does not oxidise 11DCORST	yes	reactome/R-HSA-5600598.md	Defective CYP11B2 does not oxidise 11DCORST	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing CYP11B2 catalysis at the mitochondrial inner membrane.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	26	R-HSA-6785244	Defective CYP11B2 does not oxidise 18HCORST	yes	reactome/R-HSA-6785244.md	Defective CYP11B2 does not oxidise 18HCORST	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (disease reaction) placing CYP11B2 at the mitochondrial inner membrane.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	27	R-HSA-6785245	Defective CYP11B2 does not oxidise CORST	yes	reactome/R-HSA-6785245.md	Defective CYP11B2 does not oxidise CORST	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (disease reaction) placing CYP11B2 at the mitochondrial inner membrane.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	28	R-HSA-193965	CYP11B2 oxidises 18HCORST to ALDO	yes	reactome/R-HSA-193965.md	CYP11B2 oxidises 18HCORST to ALDO	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS (reaction ""CYP11B2 oxidises 18HCORST to ALDO"") placing CYP11B2 at the mitochondrial inner membrane."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	29	R-HSA-193995	CYP11B2 18-hydroxylates CORST to 18HCORST	yes	reactome/R-HSA-193995.md	CYP11B2 18-hydroxylates CORST to 18HCORST	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS (reaction ""CYP11B2 18-hydroxylates CORST to 18HCORST"") placing CYP11B2 at the mitochondrial inner membrane."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	30	R-HSA-194017	CYP11B2 oxidises 11DCORST to CORST	yes	reactome/R-HSA-194017.md	CYP11B2 oxidises 11DCORST to CORST	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS (reaction ""CYP11B2 oxidises 11DCORST to CORST"") placing CYP11B2 at the mitochondrial inner membrane."
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	31	R-HSA-193965	CYP11B2 oxidises 18HCORST to ALDO	yes	reactome/R-HSA-193965.md	CYP11B2 oxidises 18HCORST to ALDO	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS grouping CYP11B2's activity under steroid hydroxylase activity. Correct parent term encompassing its 11-beta- and 18-hydroxylase activities.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	32	R-HSA-193995	CYP11B2 18-hydroxylates CORST to 18HCORST	yes	reactome/R-HSA-193995.md	CYP11B2 18-hydroxylates CORST to 18HCORST	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS grouping CYP11B2 under steroid hydroxylase activity (from the 18-hydroxylation reaction). Correct parent term.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	33	R-HSA-6785244	Defective CYP11B2 does not oxidise 18HCORST	yes	reactome/R-HSA-6785244.md	Defective CYP11B2 does not oxidise 18HCORST	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (disease reaction) grouping CYP11B2 under steroid hydroxylase activity.
human	CYP11B2	genes/human/CYP11B2/CYP11B2-ai-review.yaml	CYP11B2	P19099	NCBITaxon:9606	Homo sapiens	34	R-HSA-6785245	Defective CYP11B2 does not oxidise CORST	yes	reactome/R-HSA-6785245.md	Defective CYP11B2 does not oxidise CORST	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (disease reaction) grouping CYP11B2 under steroid hydroxylase activity.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	16	R-HSA-193048	Androgen biosynthesis	yes	reactome/R-HSA-193048.md	Androgen biosynthesis	Homo sapiens	GO:0006702	androgen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Via its 17,20-lyase activity, CYP17A1 catalyzes the committed step that generates C19 androgen precursors (DHEA, androstenedione), so androgen biosynthetic process is a correct core biological process.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	17	R-HSA-194002	Glucocorticoid biosynthesis	yes	reactome/R-HSA-194002.md	Glucocorticoid biosynthesis	Homo sapiens	GO:0006704	glucocorticoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	The 17-alpha-hydroxylase activity of CYP17A1 produces 17-alpha-hydroxyprogesterone, the precursor required for cortisol (glucocorticoid) synthesis, so glucocorticoid biosynthetic process is a correct core biological process.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	19	R-HSA-193068	CYP17A1 17-hydroxylates PREG	yes	reactome/R-HSA-193068.md	CYP17A1 17-hydroxylates PREG	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""CYP17A1 17-hydroxylates PREG"" annotates the core steroid 17-alpha-monooxygenase activity."
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	20	R-HSA-193070	CYP17A1 cleaves 17aHPREG to DHA	yes	reactome/R-HSA-193070.md	CYP17A1 cleaves 17aHPREG to DHA	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""CYP17A1 cleaves 17aHPREG to DHA"" annotates the core steroid 17-alpha-monooxygenase/lyase activity (DHEA production)."
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	21	R-HSA-193072	CYP17A1 17-hydroxylates P4 to 17aHPROG	yes	reactome/R-HSA-193072.md	CYP17A1 17-hydroxylates P4 to 17aHPROG	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""CYP17A1 17-hydroxylates P4 to 17aHPROG"" annotates the core steroid 17-alpha-monooxygenase activity (progesterone hydroxylation)."
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	22	R-HSA-193099	CYP17A1 cleaves 17aHPROG to ANDST	yes	reactome/R-HSA-193099.md	CYP17A1 cleaves 17aHPROG to ANDST	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""CYP17A1 cleaves 17aHPROG to ANDST"" annotates the core steroid 17-alpha-monooxygenase/lyase activity (androstenedione production)."
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	23	R-HSA-5601843	Defective CYP17A1 does not 17-hydroxylate PREG	yes	reactome/R-HSA-5601843.md	Defective CYP17A1 does not 17-hydroxylate PREG	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction (defective CYP17A1 does not 17-hydroxylate PREG) annotates the core steroid 17-alpha-monooxygenase activity in the context of loss-of-function disease.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	24	R-HSA-9035954	Defective CYP17A1 does not 17-hydroxylate P4	yes	reactome/R-HSA-9035954.md	Defective CYP17A1 does not 17-hydroxylate P4	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction (defective CYP17A1 does not 17-hydroxylate P4) annotates the core steroid 17-alpha-monooxygenase activity in the loss-of-function disease context.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	25	R-HSA-9035956	Defective CYP17A1 does not cleave 17aHPROG	yes	reactome/R-HSA-9035956.md	Defective CYP17A1 does not cleave 17aHPROG	Homo sapiens	GO:0004508	steroid 17-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction (defective CYP17A1 does not cleave 17aHPROG) annotates the core steroid 17-alpha-monooxygenase/lyase activity in the loss-of-function disease context.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	32	R-HSA-5601843	Defective CYP17A1 does not 17-hydroxylate PREG	yes	reactome/R-HSA-5601843.md	Defective CYP17A1 does not 17-hydroxylate PREG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the endoplasmic reticulum membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	33	R-HSA-9035954	Defective CYP17A1 does not 17-hydroxylate P4	yes	reactome/R-HSA-9035954.md	Defective CYP17A1 does not 17-hydroxylate P4	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the endoplasmic reticulum membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	34	R-HSA-9035956	Defective CYP17A1 does not cleave 17aHPROG	yes	reactome/R-HSA-9035956.md	Defective CYP17A1 does not cleave 17aHPROG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the endoplasmic reticulum membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	41	R-HSA-193068	CYP17A1 17-hydroxylates PREG	yes	reactome/R-HSA-193068.md	CYP17A1 17-hydroxylates PREG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the ER membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	42	R-HSA-193070	CYP17A1 cleaves 17aHPREG to DHA	yes	reactome/R-HSA-193070.md	CYP17A1 cleaves 17aHPREG to DHA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the ER membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	43	R-HSA-193072	CYP17A1 17-hydroxylates P4 to 17aHPROG	yes	reactome/R-HSA-193072.md	CYP17A1 17-hydroxylates P4 to 17aHPROG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the ER membrane, consistent with the microsomal P450 subcellular location.
human	CYP17A1	genes/human/CYP17A1/CYP17A1-ai-review.yaml	CYP17A1	P05093	NCBITaxon:9606	Homo sapiens	44	R-HSA-193099	CYP17A1 cleaves 17aHPROG to ANDST	yes	reactome/R-HSA-193099.md	CYP17A1 cleaves 17aHPROG to ANDST	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localizes the CYP17A1 reaction to the ER membrane, consistent with the microsomal P450 subcellular location.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	16	R-HSA-193144	Estrogen biosynthesis	yes	reactome/R-HSA-193144.md	Estrogen biosynthesis	Homo sapiens	GO:0006703	estrogen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation to estrogen biosynthesis, the core biological process of aromatase (committed, rate-limiting step converting androgens to estrogens).
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	17	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Aromatase acts on C19 androgens and produces C18 estrogens, which are steroid hormones, not sterols; aromatase does not metabolize sterols (e.g. cholesterol). Sterol metabolic process is an over-broad/imprecise grouping for this enzyme.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	22	R-HSA-193060	CYP19A1 hydroxylates ANDST to E1	yes	reactome/R-HSA-193060.md	CYP19A1 hydroxylates ANDST to E1	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Steroid hydroxylase activity is a correct general parent describing the first two (C19 hydroxylation) steps of the aromatase reaction, but it is over-general relative to the specific aromatase activity (GO:0070330).
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	23	R-HSA-193143	CYP19A1 hydroxylates TEST to EST17b	yes	reactome/R-HSA-193143.md	CYP19A1 hydroxylates TEST to EST17b	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Duplicate Reactome annotation of the general steroid hydroxylase parent (for the testosterone -> estradiol reaction); over-general relative to aromatase activity.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	24	R-HSA-5601849	Defective CYP19A1 does not convert ANDST to E1	yes	reactome/R-HSA-5601849.md	Defective CYP19A1 does not convert ANDST to E1	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Duplicate Reactome annotation of the general steroid hydroxylase parent (defective-aromatase pathway); over-general relative to the specific aromatase activity.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	28	R-HSA-5601849	Defective CYP19A1 does not convert ANDST to E1	yes	reactome/R-HSA-5601849.md	Defective CYP19A1 does not convert ANDST to E1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to the ER membrane, the core cellular location of the microsomal aromatase.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	29	R-HSA-193060	CYP19A1 hydroxylates ANDST to E1	yes	reactome/R-HSA-193060.md	CYP19A1 hydroxylates ANDST to E1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation to the ER membrane (androstenedione -> estrone reaction context); correct core location.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	30	R-HSA-193143	CYP19A1 hydroxylates TEST to EST17b	yes	reactome/R-HSA-193143.md	CYP19A1 hydroxylates TEST to EST17b	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation to the ER membrane (testosterone -> estradiol reaction context); correct core location.
human	CYP19A1	genes/human/CYP19A1/CYP19A1-ai-review.yaml	CYP19A1	P11511	NCBITaxon:9606	Homo sapiens	31	R-HSA-9707353	CYP19A1 binds Aromatase inhibitors	yes	reactome/R-HSA-9707353.md	CYP19A1 binds Aromatase inhibitors	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation to the ER membrane (aromatase-inhibitor binding context); correct core location.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	17	R-HSA-194002	Glucocorticoid biosynthesis	yes	reactome/R-HSA-194002.md	Glucocorticoid biosynthesis	Homo sapiens	GO:0006704	glucocorticoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of CYP21A2 in glucocorticoid biosynthesis, consistent with the IBA annotation and the enzyme's role generating 11-deoxycortisol en route to cortisol. Core biological process.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	18	R-HSA-193993	Mineralocorticoid biosynthesis	yes	reactome/R-HSA-193993.md	Mineralocorticoid biosynthesis	Homo sapiens	GO:0006705	mineralocorticoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of CYP21A2 in mineralocorticoid biosynthesis, consistent with the ARBA IEA and the progesterone-to-DOC reaction feeding aldosterone. Core biological process.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	19	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome (TAS) assignment to the broad sterol metabolic process (""Endogenous sterols""). Steroids are derived from sterols, but this is a broad parent of the specific corticosteroid-biosynthesis processes; not the core term."
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	20	R-HSA-5601976	Defective CYP21A2 does not 21-hydroxylate PROG	yes	reactome/R-HSA-5601976.md	Defective CYP21A2 does not 21-hydroxylate PROG	Homo sapiens	GO:0004509	steroid 21-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of the core catalytic activity, in the context of defective CYP21A2 failing to 21-hydroxylate progesterone. Correct core molecular function.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	21	R-HSA-193964	CYP21A2 21-hydroxylates PROG	yes	reactome/R-HSA-193964.md	CYP21A2 21-hydroxylates PROG	Homo sapiens	GO:0106309	progesterone 21-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of the specific progesterone 21-hydroxylase reaction (CYP21A2 21-hydroxylates PROG). Correct and appropriately specific.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	22	R-HSA-193981	CYP21A2 oxidises 17HPROG	yes	reactome/R-HSA-193981.md	CYP21A2 oxidises 17HPROG	Homo sapiens	GO:0106309	progesterone 21-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of progesterone 21-hydroxylase activity (duplicate of the reaction annotation via a different Reactome event). Correct and appropriately specific.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	23	R-HSA-5601976	Defective CYP21A2 does not 21-hydroxylate PROG	yes	reactome/R-HSA-5601976.md	Defective CYP21A2 does not 21-hydroxylate PROG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization, consistent with the IDA and IEA localizations. Correct core cellular component.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	37	R-HSA-193964	CYP21A2 21-hydroxylates PROG	yes	reactome/R-HSA-193964.md	CYP21A2 21-hydroxylates PROG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization (progesterone 21-hydroxylation event), consistent with the IDA and other localizations. Correct core cellular component.
human	CYP21A2	genes/human/CYP21A2/CYP21A2-ai-review.yaml	CYP21A2	P08686	NCBITaxon:9606	Homo sapiens	38	R-HSA-193981	CYP21A2 oxidises 17HPROG	yes	reactome/R-HSA-193981.md	CYP21A2 oxidises 17HPROG	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization (17-hydroxyprogesterone oxidation event), consistent with the IDA and other localizations. Correct core cellular component.
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	17	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile acid/bile salt synthesis via 7alpha-hydroxycholesterol, the neutral pathway). Core biological process: CYP27A1 performs the side-chain oxidation steps of bile-acid biosynthesis. Accept.
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	18	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile acid synthesis via 24-hydroxycholesterol pathway). Core biological process for CYP27A1; accept (duplicate of the bile-acid biosynthesis annotation).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	19	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (bile acid synthesis via 27-hydroxycholesterol, the acidic/alternative pathway that CYP27A1 initiates). Core biological process; accept.
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	20	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (endogenous sterols) to the broad sterol metabolic process. Correct but general; the specific cholesterol/bile-acid processes are captured by more precise terms. Accept as a valid parent.
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	31	R-HSA-191999	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol	yes	reactome/R-HSA-191999.md	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (CYP27A1 27-hydroxylates 5b-cholestane-3a,7a,12a-triol). Correct; a general parent of the specific sterol 26/27-hydroxylase activity. Accept.
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	32	R-HSA-192042	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al	yes	reactome/R-HSA-192042.md	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 side-chain oxidation step in bile-acid biosynthesis; steroid hydroxylase is a correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	33	R-HSA-192054	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)	yes	reactome/R-HSA-192054.md	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 bile-acid side-chain oxidation step; steroid hydroxylase is a correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	34	R-HSA-192123	CYP27A1 27-hydroxylates CHOL	yes	reactome/R-HSA-192123.md	CYP27A1 27-hydroxylates CHOL	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (CYP27A1 27-hydroxylates cholesterol); steroid hydroxylase is a correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	35	R-HSA-193393	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol	yes	reactome/R-HSA-193393.md	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	36	R-HSA-193460	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)	yes	reactome/R-HSA-193460.md	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 side-chain oxidation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	37	R-HSA-193497	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al	yes	reactome/R-HSA-193497.md	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	38	R-HSA-193713	TODO: Fetch title	no				GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	39	R-HSA-193719	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al	yes	reactome/R-HSA-193719.md	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	40	R-HSA-193737	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)	yes	reactome/R-HSA-193737.md	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 side-chain oxidation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	41	R-HSA-193780	TODO: Fetch title	no				GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	42	R-HSA-193787	TODO: Fetch title	no				GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for a CYP27A1 sterol-hydroxylation step; correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	43	R-HSA-193792	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol	yes	reactome/R-HSA-193792.md	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (CYP27A1 27-hydroxylates 5b-CHOL3a,7a,24(s)-triol); correct general parent MF. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	44	R-HSA-5602170	CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol	yes	reactome/R-HSA-5602170.md	CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS from a 'CYP27A1 does not 27-hydroxylate ...' reaction record, but annotated as enabling steroid hydroxylase activity. The general MF is correct for CYP27A1; accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	45	R-HSA-9035960	Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol	yes	reactome/R-HSA-9035960.md	Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol	Homo sapiens	GO:0008395	steroid hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (defective CYP27A1 reaction record) annotated as enabling steroid hydroxylase activity; the general MF is correct for wild-type CYP27A1. Accept (duplicate).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	54	R-HSA-5602170	CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol	yes	reactome/R-HSA-5602170.md	CYP27A1 does not 27-hydroxylate 5bCHOL3a,7a,12a-triol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS placing CYP27A1 in the mitochondrial matrix. Consistent with UniProt: after import into the matrix, CYP27A1 associates with the inner membrane as a membrane-extrinsic protein, so it faces the matrix. Keep as non-core; the specific location is the inner membrane (matrix face).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	55	R-HSA-9035960	Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol	yes	reactome/R-HSA-9035960.md	Defective CYP27A1 does not 27-hydroxylate 5β-CHOL3α,7α,24(s)-triol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	56	R-HSA-191999	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol	yes	reactome/R-HSA-191999.md	CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	57	R-HSA-192042	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al	yes	reactome/R-HSA-192042.md	5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	58	R-HSA-192054	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)	yes	reactome/R-HSA-192054.md	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	59	R-HSA-192123	CYP27A1 27-hydroxylates CHOL	yes	reactome/R-HSA-192123.md	CYP27A1 27-hydroxylates CHOL	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	60	R-HSA-193393	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol	yes	reactome/R-HSA-193393.md	5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	61	R-HSA-193460	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)	yes	reactome/R-HSA-193460.md	3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	62	R-HSA-193497	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al	yes	reactome/R-HSA-193497.md	5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	63	R-HSA-193713	TODO: Fetch title	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	64	R-HSA-193719	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al	yes	reactome/R-HSA-193719.md	5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	65	R-HSA-193737	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)	yes	reactome/R-HSA-193737.md	3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	66	R-HSA-193780	TODO: Fetch title	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	67	R-HSA-193787	TODO: Fetch title	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP27A1	genes/human/CYP27A1/CYP27A1-ai-review.yaml	CYP27A1	Q02318	NCBITaxon:9606	Homo sapiens	68	R-HSA-193792	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol	yes	reactome/R-HSA-193792.md	CYP27A1 27-hydroxylates 5β-CHOL3α,7α,24(s)-triol	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for mitochondrial matrix localization; keep as non-core (see above).
human	CYP39A1	genes/human/CYP39A1/CYP39A1-ai-review.yaml	CYP39A1	Q9NYL5	NCBITaxon:9606	Homo sapiens	16	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Correct core BP, curated by Reactome as the pathway ""Synthesis of bile acids and bile salts via 24-hydroxycholesterol,"" in which CYP39A1 performs the initiating 7-alpha-hydroxylation. Consistent with experimental evidence."
human	CYP39A1	genes/human/CYP39A1/CYP39A1-ai-review.yaml	CYP39A1	Q9NYL5	NCBITaxon:9606	Homo sapiens	17	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Correct but general BP, curated by Reactome (""Endogenous sterols"") for P450s that participate in cholesterol/sterol metabolism and homeostasis. A true ancestor of the specific bile-acid/cholesterol-catabolic processes; kept as non-core."
human	CYP39A1	genes/human/CYP39A1/CYP39A1-ai-review.yaml	CYP39A1	Q9NYL5	NCBITaxon:9606	Homo sapiens	19	R-HSA-192178	CYP39A1 7-hydroxylates 24OH-CHOL	yes	reactome/R-HSA-192178.md	CYP39A1 7-hydroxylates 24OH-CHOL	Homo sapiens	GO:0008396	oxysterol 7-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	"Correct. UniProt lists ""Oxysterol 7-alpha-hydroxylase"" as an alternative name and CYP39A1 was cloned as such. This is a valid MF; however, CYP39A1 is specifically selective for 24-hydroxycholesterol, so the more precise GO:0033782 better captures the substrate specificity. Retained."
human	CYP39A1	genes/human/CYP39A1/CYP39A1-ai-review.yaml	CYP39A1	Q9NYL5	NCBITaxon:9606	Homo sapiens	22	R-HSA-192178	CYP39A1 7-hydroxylates 24OH-CHOL	yes	reactome/R-HSA-192178.md	CYP39A1 7-hydroxylates 24OH-CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Correct core localization, curated by Reactome for the reaction ""CYP39A1 7-hydroxylates 24OH-CHOL,"" which places the enzyme on the ER membrane. Consistent with the UniProt and ISS calls."
human	CYP46A1	genes/human/CYP46A1/CYP46A1-ai-review.yaml	CYP46A1	Q9Y6A2	NCBITaxon:9606	Homo sapiens	18	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) pathway annotation. CYP46A1's product 24S-hydroxycholesterol is exported from the brain to the liver where it feeds an alternative, minor bile-acid biosynthetic pathway. This is a downstream, whole-body pathway role rather than the enzyme's core neuronal cholesterol-elimination function; kept as non-core.
human	CYP46A1	genes/human/CYP46A1/CYP46A1-ai-review.yaml	CYP46A1	Q9Y6A2	NCBITaxon:9606	Homo sapiens	19	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) high-level biological process. Correct but generic parent of the specific cholesterol catabolic process; kept as a true but non-core generalization.
human	CYP46A1	genes/human/CYP46A1/CYP46A1-ai-review.yaml	CYP46A1	Q9Y6A2	NCBITaxon:9606	Homo sapiens	21	R-HSA-192061	CYP46A1 24-hydroxylates CHOL	yes	reactome/R-HSA-192061.md	CYP46A1 24-hydroxylates CHOL	Homo sapiens	GO:0033781	cholesterol 24-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of the core catalytic activity (CYP46A1 24-hydroxylates cholesterol). Redundant with experimental annotations; the defining molecular function.
human	CYP46A1	genes/human/CYP46A1/CYP46A1-ai-review.yaml	CYP46A1	Q9Y6A2	NCBITaxon:9606	Homo sapiens	40	R-HSA-192061	CYP46A1 24-hydroxylates CHOL	yes	reactome/R-HSA-192061.md	CYP46A1 24-hydroxylates CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane location, consistent with the UniProt annotation and original cloning study. Core cellular location.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	11	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation placing CYP51A1 in cholesterol biosynthesis (Bloch pathway). CYP51A1 catalyzes the first post-lanosterol demethylation step; this is a core biological process for the gene.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	12	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to the broader sterol metabolic process. Correct but more general than cholesterol biosynthetic process (GO:0006695), which is the specific pathway CYP51A1 acts in.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	15	R-HSA-194678	CYP51A1 demethylates LAN	yes	reactome/R-HSA-194678.md	CYP51A1 demethylates LAN	Homo sapiens	GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to a mechanistic parent term describing the P450 monooxygenase reaction coupled to a flavoprotein (NADPH-cytochrome P450 reductase) donor. Correct mechanistically but less specific than GO:0008398.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	16	R-HSA-6807062	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	yes	reactome/R-HSA-6807062.md	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation placing CYP51A1 in cholesterol biosynthesis (Kandutsch-Russell pathway, via 24,25-dihydrolanosterol/lathosterol). Core biological process; CYP51A1 demethylates both lanosterol and 24,25-dihydrolanosterol.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	17	R-HSA-1655847	Expression of Lanosterol Demethylase (CYP51A1)	yes	reactome/R-HSA-1655847.md	Expression of Lanosterol Demethylase (CYP51A1)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane. Consistent with the microsomal P450 nature of CYP51A1 and with UniProt subcellular location.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	18	R-HSA-194678	CYP51A1 demethylates LAN	yes	reactome/R-HSA-194678.md	CYP51A1 demethylates LAN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane (duplicate of other ER-membrane annotations). Correct core localization.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	19	R-HSA-9621404	CYP51A1 gene expression	yes	reactome/R-HSA-9621404.md	CYP51A1 gene expression	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane (duplicate). Correct core localization for this microsomal P450.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	20	R-HSA-9947148	CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol	yes	reactome/R-HSA-9947148.md	CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane (duplicate), from the reaction in which CYP51A1 14-demethylates 24,25-dihydrolanosterol. Correct core localization.
human	CYP51A1	genes/human/CYP51A1/CYP51A1-ai-review.yaml	CYP51A1	Q16850	NCBITaxon:9606	Homo sapiens	21	R-HSA-191273	Cholesterol biosynthesis	yes	reactome/R-HSA-191273.md	Cholesterol biosynthesis	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation to the overall cholesterol biosynthesis pathway. Core biological process for CYP51A1.
human	CYP7A1	genes/human/CYP7A1/CYP7A1-ai-review.yaml	CYP7A1	P22680	NCBITaxon:9606	Homo sapiens	23	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Core biological process, curated by Reactome as the classic bile-acid synthesis pathway initiated by CYP7A1.
human	CYP7A1	genes/human/CYP7A1/CYP7A1-ai-review.yaml	CYP7A1	P22680	NCBITaxon:9606	Homo sapiens	24	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Correct but general Reactome-curated term (CYP7A1 within the Endogenous sterols grouping). Subsumed by the specific cholesterol catabolic / bile acid biosynthetic terms.
human	CYP7A1	genes/human/CYP7A1/CYP7A1-ai-review.yaml	CYP7A1	P22680	NCBITaxon:9606	Homo sapiens	25	R-HSA-192051	CYP7A1 7-hydroxylates CHOL	yes	reactome/R-HSA-192051.md	CYP7A1 7-hydroxylates CHOL	Homo sapiens	GO:0008123	cholesterol 7-alpha-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Core molecular function, curated by Reactome as the CYP7A1 7-hydroxylation of cholesterol reaction.
human	CYP7A1	genes/human/CYP7A1/CYP7A1-ai-review.yaml	CYP7A1	P22680	NCBITaxon:9606	Homo sapiens	30	R-HSA-192051	CYP7A1 7-hydroxylates CHOL	yes	reactome/R-HSA-192051.md	CYP7A1 7-hydroxylates CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Core cellular component, Reactome-curated ER-membrane localization of the CYP7A1 reaction.
human	CYP7A1	genes/human/CYP7A1/CYP7A1-ai-review.yaml	CYP7A1	P22680	NCBITaxon:9606	Homo sapiens	31	R-HSA-1989746	Expression of CYP7A1	yes	reactome/R-HSA-1989746.md	Expression of CYP7A1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER-membrane localization annotation attributed to the Expression of CYP7A1 Reactome event, which is actually a gene transcription/translation event. The localization itself is correct (well supported by R-HSA-192051 and UniProt).
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	16	R-HSA-192105	Synthesis of bile acids and bile salts	yes	reactome/R-HSA-192105.md	Synthesis of bile acids and bile salts	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (Synthesis of bile acids and bile salts) for bile acid biosynthetic process. Consistent with the core biological role of CYP7B1.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	17	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (Synthesis of bile acids and bile salts via 27-hydroxycholesterol) for bile acid biosynthetic process. This is precisely the acidic pathway in which CYP7B1 7-alpha-hydroxylates 27-hydroxycholesterol.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	18	R-HSA-211976	Endogenous sterols	yes	reactome/R-HSA-211976.md	Endogenous sterols	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (Endogenous sterols) for sterol metabolic process. CYP7B1 metabolizes oxysterols (oxygenated sterols), so this broad BP is correct.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	19	R-HSA-191972	27-hydroxycholesterol is 7alpha-hydroxylated	yes	reactome/R-HSA-191972.md	27-hydroxycholesterol is 7alpha-hydroxylated	Homo sapiens	GO:0008396	oxysterol 7-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (27-hydroxycholesterol is 7alpha-hydroxylated) for oxysterol 7-alpha-hydroxylase activity. This is the specific, core molecular function of CYP7B1.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	20	R-HSA-192065	CYP7B1 7-hydroxylates 25OH-CHOL	yes	reactome/R-HSA-192065.md	CYP7B1 7-hydroxylates 25OH-CHOL	Homo sapiens	GO:0008396	oxysterol 7-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (CYP7B1 7-hydroxylates 25OH-CHOL) for oxysterol 7-alpha-hydroxylase activity. Specific, core MF; consistent with the experimental 25-hydroxycholesterol activity.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	21	R-HSA-5602885	Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL	yes	reactome/R-HSA-5602885.md	Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL	Homo sapiens	GO:0008396	oxysterol 7-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL) for oxysterol 7-alpha-hydroxylase activity, framed around the disease (SPG5A/CBAS3) loss of activity. Correct specific core MF.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	26	R-HSA-5602885	Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL	yes	reactome/R-HSA-5602885.md	Defective CYP7B1 does not 7-hydroxylate 25OH-CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for endoplasmic reticulum membrane localization. Correct, core localization for this microsomal P450.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	27	R-HSA-191972	27-hydroxycholesterol is 7alpha-hydroxylated	yes	reactome/R-HSA-191972.md	27-hydroxycholesterol is 7alpha-hydroxylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER membrane localization (duplicate of the core CC annotation). Correct.
human	CYP7B1	genes/human/CYP7B1/CYP7B1-ai-review.yaml	CYP7B1	O75881	NCBITaxon:9606	Homo sapiens	28	R-HSA-192065	CYP7B1 7-hydroxylates 25OH-CHOL	yes	reactome/R-HSA-192065.md	CYP7B1 7-hydroxylates 25OH-CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER membrane localization (duplicate of the core CC annotation). Correct.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	12	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Correct core biological process (Reactome bile-salt synthesis via 7-alpha-hydroxycholesterol, the classic pathway in which CYP8B1 is the 12-alpha-hydroxylation branch step). Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	13	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Correct core biological process (Reactome bile-salt synthesis pathway). Redundant with the other bile-acid biosynthesis annotations. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	14	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Correct core biological process (Reactome bile-salt synthesis pathway). Redundant Reactome TAS for bile-acid biosynthesis. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	15	R-HSA-211994	Sterols are 12-hydroxylated by CYP8B1	yes	reactome/R-HSA-211994.md	Sterols are 12-hydroxylated by CYP8B1	Homo sapiens	GO:0016125	sterol metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Correct but general. CYP8B1 acts on sterol intermediates, but its role is best captured by the specific bile acid biosynthetic process (GO:0006699) plus the sterol 12-alpha-hydroxylase MF. Keep as non-core context.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	17	R-HSA-192157	CYP8B1 12-hydroxylates 4CHOL7aOLONE	yes	reactome/R-HSA-192157.md	CYP8B1 12-hydroxylates 4CHOL7aOLONE	Homo sapiens	GO:0008397	sterol 12-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the defining reaction (CYP8B1 12-hydroxylates 7-alpha-hydroxycholest-4-en-3-one). Correct core molecular function. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	18	R-HSA-193709	TODO: Fetch title	no				GO:0008397	sterol 12-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the sterol 12-alpha-hydroxylase reaction. Correct core molecular function; redundant Reactome support. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	19	R-HSA-193845	CYP8B1 12-hydroxylates 4CHOL7a,27DONE	yes	reactome/R-HSA-193845.md	CYP8B1 12-hydroxylates 4CHOL7a,27DONE	Homo sapiens	GO:0008397	sterol 12-alpha-hydroxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the defining reaction (CYP8B1 12-hydroxylates 7-alpha,27-dihydroxy intermediate). Correct core molecular function. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	28	R-HSA-192157	CYP8B1 12-hydroxylates 4CHOL7aOLONE	yes	reactome/R-HSA-192157.md	CYP8B1 12-hydroxylates 4CHOL7aOLONE	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing CYP8B1 activity at the ER membrane. Correct location; redundant with ISS/IEA. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	29	R-HSA-193709	TODO: Fetch title	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the ER-membrane location. Correct; redundant Reactome support. Accept.
human	CYP8B1	genes/human/CYP8B1/CYP8B1-ai-review.yaml	CYP8B1	Q9UNU6	NCBITaxon:9606	Homo sapiens	30	R-HSA-193845	CYP8B1 12-hydroxylates 4CHOL7a,27DONE	yes	reactome/R-HSA-193845.md	CYP8B1 12-hydroxylates 4CHOL7a,27DONE	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the ER-membrane location. Correct; redundant Reactome support. Accept.
human	DAB2IP	genes/human/DAB2IP/DAB2IP-ai-review.yaml	DAB2IP	Q5VWQ8	NCBITaxon:9606	Homo sapiens	75	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization for Ras-GAP function.
human	DAB2IP	genes/human/DAB2IP/DAB2IP-ai-review.yaml	DAB2IP	Q5VWQ8	NCBITaxon:9606	Homo sapiens	76	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	20	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) ER membrane localization from the ""Transfer of N-glycan to the protein"" reaction, in which DAD1 is listed as a component of the OST complex. Correct core CC; accept."
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	21	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from an OST-catalyzed N-glycosylation reaction (viral spike protein). Correct core CC, redundant with the other ER membrane annotations; accept.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	22	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from the CDH1 (E-cadherin) N-glycosylation reaction catalyzed by OST. Correct core CC, redundant; accept.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	23	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from an OST-catalyzed N-glycosylation reaction. Correct core CC, redundant; accept.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	24	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from an OST-catalyzed N-glycosylation reaction. Correct core CC, redundant; accept.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	25	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from an OST-catalyzed N-glycosylation reaction. Correct core CC, redundant; accept.
human	DAD1	genes/human/DAD1/DAD1-ai-review.yaml	DAD1	P61803	NCBITaxon:9606	Homo sapiens	26	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from the PD-L1 (CD274) N-glycosylation reaction catalyzed by the OST complex in the ER lumen. Correct core CC, redundant; accept.
human	DARS2	genes/human/DARS2/DARS2-ai-review.yaml	DARS2	Q6PI48	NCBITaxon:9606	Homo sapiens	40	R-HSA-380229	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate	yes	reactome/R-HSA-380229.md	aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	mitochondrial matrix: Human DARS2 is a dimeric mitochondrial aspartate-tRNA synthetase, with direct aminoacylation and structural evidence. Binding ATP and tRNA and producing charged mitochondrial tRNA(Asp) are parts of this core reaction; mitochondrial localization is independently supported.
human	DBH	genes/human/DBH/DBH-ai-review.yaml	DBH	P09172	NCBITaxon:9606	Homo sapiens	40	R-HSA-209891	Dopamine is oxidised to noradrenaline	yes	reactome/R-HSA-209891.md	Dopamine is oxidised to noradrenaline	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Reactome-curated secretory granule lumen localization of the soluble form, consistent with the experimental IDA annotation to the same term. Core location.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	16	R-HSA-70895	Branched-chain amino acid catabolism	yes	reactome/R-HSA-70895.md	Branched-chain amino acid catabolism	Homo sapiens	GO:0009083	branched-chain amino acid catabolic process	TAS	involved_in	BP	false		ACCEPT	"Core biological process (Reactome pathway ""Branched-chain amino acid catabolism""), duplicate of the IEA/IDA annotations."
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	25	R-HSA-9865115	DBT loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Broad acyltransferase parent term from Reactome (DBT loss-of-function reaction).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	26	R-HSA-9865115	DBT loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	27	R-HSA-9859148	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (BCKDHA:BCKDHB decarboxylation reaction).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	28	R-HSA-9859163	DBT transfers BCAA to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	29	R-HSA-9859172	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (DLD dehydrogenation step).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	30	R-HSA-9907572	Loss-of-function DLD mutants don't dehydrogenate dihydrolipoyl DBT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	31	R-HSA-9859163	DBT transfers BCAA to CoA	no				GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Broad acyltransferase parent term from Reactome.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	32	R-HSA-5693148	BCKDK phosphorylates BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	33	R-HSA-5693153	PPM1K dephosphorylates p-BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (PPM1K dephosphorylates p-BCKDH).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	34	R-HSA-6792572	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	yes	reactome/R-HSA-6792572.md	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	35	R-HSA-9865121	BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization.
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	36	R-HSA-9912480	BCKDK loss-of-function mutations do not phosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (BCKDK loss-of-function).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	37	R-HSA-9912527	H139Hfs13* PPM1K does not dephosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (PPM1K variant).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	39	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (LONP1 degrades matrix proteins).
human	DBT	genes/human/DBT/DBT-ai-review.yaml	DBT	P11182	NCBITaxon:9606	Homo sapiens	40	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial matrix localization (LONP1 binds matrix proteins).
human	DCAF10	genes/human/DCAF10/DCAF10-ai-review.yaml	DCAF10	Q5QP82	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization asserted via a generic Reactome CRL4 neddylation/assembly reaction (AcM-UBE2M transfers NEDD8 to CRL4) in which DCAF10 stands in as one of many possible interchangeable DCAFs. Not DCAF10-specific experimental localization.
human	DCAF10	genes/human/DCAF10/DCAF10-ai-review.yaml	DCAF10	Q5QP82	NCBITaxon:9606	Homo sapiens	10	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from a generic Reactome CRL4 reaction (NEDD8:AcM-UBE2M binds CRL4) where DCAF10 represents a generic DCAF; not DCAF10-specific localization evidence.
human	DCAF10	genes/human/DCAF10/DCAF10-ai-review.yaml	DCAF10	Q5QP82	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from a generic Reactome CRL4 reaction (CAND1 binds CRL4 in the nucleus) where DCAF10 represents a generic DCAF; not DCAF10-specific localization evidence.
human	DCAF10	genes/human/DCAF10/DCAF10-ai-review.yaml	DCAF10	Q5QP82	NCBITaxon:9606	Homo sapiens	12	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from a generic Reactome CRL4 reaction (COMMDs displace CAND1 from CRL4) where DCAF10 represents a generic DCAF; not DCAF10-specific localization evidence.
human	DCAF10	genes/human/DCAF10/DCAF10-ai-review.yaml	DCAF10	Q5QP82	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from a generic Reactome CRL4 reaction (COP9 signalosome deneddylates nuclear CRL4) where DCAF10 represents a generic DCAF; not DCAF10-specific localization evidence.
human	DCAF11	genes/human/DCAF11/DCAF11-ai-review.yaml	DCAF11	Q8TEB1	NCBITaxon:9606	Homo sapiens	17	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the CRL4 complex (here DCAF11) in the nucleoplasm during the neddylation/deneddylation regulatory cycle. Consistent with the IDA nucleoplasm localization.
human	DCAF11	genes/human/DCAF11/DCAF11-ai-review.yaml	DCAF11	Q8TEB1	NCBITaxon:9606	Homo sapiens	18	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the CRL4 complex (here DCAF11) in the nucleoplasm during the neddylation regulatory cycle. Consistent with the IDA nucleoplasm localization.
human	DCAF11	genes/human/DCAF11/DCAF11-ai-review.yaml	DCAF11	Q8TEB1	NCBITaxon:9606	Homo sapiens	19	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the CRL4 complex (here DCAF11) in the nucleoplasm during the CAND1 exchange cycle. Consistent with the IDA nucleoplasm localization.
human	DCAF11	genes/human/DCAF11/DCAF11-ai-review.yaml	DCAF11	Q8TEB1	NCBITaxon:9606	Homo sapiens	20	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the CRL4 complex (here DCAF11) in the nucleoplasm during COMMD-mediated CAND1 displacement. Consistent with the IDA nucleoplasm localization.
human	DCAF11	genes/human/DCAF11/DCAF11-ai-review.yaml	DCAF11	Q8TEB1	NCBITaxon:9606	Homo sapiens	21	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the CRL4 complex (here DCAF11) in the nucleoplasm during COP9 signalosome-mediated deneddylation. Consistent with the IDA nucleoplasm localization.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	9	R-HSA-2022056	DSPG and CSPG translocate to the lysosome for degradation	yes	reactome/R-HSA-2022056.md	DSPG and CSPG translocate to the lysosome for degradation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for DSPG/CSPG translocation to lysosome for degradation. Decorin (as a dermatan sulfate proteoglycan) is secreted to extracellular region and eventually degraded. Correct but redundant with other extracellular annotations.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	10	R-HSA-2022065	DSPGs are secreted	yes	reactome/R-HSA-2022065.md	DSPGs are secreted	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for DSPG secretion. Decorin as a dermatan sulfate proteoglycan is secreted to extracellular region. Correct but redundant with other extracellular annotations.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	11	R-HSA-2022911	CSPG is secreted	yes	reactome/R-HSA-2022911.md	CSPG is secreted	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for CSPG secretion. Decorin can carry chondroitin sulfate GAG chain and is secreted to extracellular region. Correct but redundant with other extracellular annotations.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	12	R-HSA-2022065	DSPGs are secreted	yes	reactome/R-HSA-2022065.md	DSPGs are secreted	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for DSPG biosynthesis/modification in Golgi during secretion. Decorin transiently passes through Golgi lumen where GAG chain is modified (SO4 transfer to GalNAc by CHST14).
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	13	R-HSA-2022911	CSPG is secreted	yes	reactome/R-HSA-2022911.md	CSPG is secreted	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for CSPG biosynthesis/secretion. Decorin transiently passes through Golgi lumen during biosynthesis where GAG chain modifications occur.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	14	R-HSA-9940993	PXYLP1 dephosphorylates Xyl moiety	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for xylose dephosphorylation by PXYLP1 during GAG chain biosynthesis. Decorin present in Golgi lumen during this modification step.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	15	R-HSA-9941039	FAM20B phosphorylates Xyl moiety	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for xylose phosphorylation by FAM20B during GAG chain biosynthesis. Decorin present in Golgi lumen during this modification step.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	16	R-HSA-9941305	UST transfers sulfate to (2-)GlcA-GalNAc-6-sulfate	yes	reactome/R-HSA-9941305.md	UST transfers sulfate to (2-)GlcA-GalNAc-6-sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer by UST to GlcA-GalNAc-6-sulfate during dermatan sulfate biosynthesis. Decorin present in Golgi during GAG chain sulfation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	17	R-HSA-9941312	CHST15 transfers sulfate to (6-)GalNAc-4-sulfate	yes	reactome/R-HSA-9941312.md	CHST15 transfers sulfate to (6-)GalNAc-4-sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer by CHST15 during GAG biosynthesis. Decorin present in Golgi during chondroitin/dermatan sulfate chain sulfation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	43	R-HSA-2022052	DSE converts GlcA to IdoA	yes	reactome/R-HSA-2022052.md	DSE converts GlcA to IdoA	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for conversion of GlcA to IdoA (DSE enzyme) during dermatan sulfate biosynthesis. Decorin transiently in Golgi during GAG modification.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	44	R-HSA-2022063	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS	yes	reactome/R-HSA-2022063.md	CHST14 transfers SO4(2-) to GalNAc in dermatan or DS	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer by CHST14 to GalNAc in dermatan sulfate. Decorin transiently in Golgi during GAG biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	45	R-HSA-3636919	Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS	yes	reactome/R-HSA-3636919.md	Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for defective CHST14 (EDS musculocontractural type mutation). Decorin present in Golgi during GAG biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	47	R-HSA-2534248	DCN (decorin) degradation by MMP2, MMP3, MMP7	yes	reactome/R-HSA-2534248.md	DCN (decorin) degradation by MMP2, MMP3, MMP7	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway for decorin degradation by MMPs (MMP2, MMP3, MMP7) in extracellular region.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	48	R-HSA-3828025	DCN (decorin) degradation by MMP14	yes	reactome/R-HSA-3828025.md	DCN (decorin) degradation by MMP14	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway for decorin degradation by MMP14 in extracellular region.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	49	R-HSA-2327909	DCN binds collagen I, II, III, VI fibrils	yes	reactome/R-HSA-2327909.md	DCN binds collagen I, II, III, VI fibrils	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway for decorin binding to collagen I, II, III, VI fibrils in extracellular region.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	50	R-NUL-2466133	SLRPs bind TGF beta	yes	reactome/R-NUL-2466133.md	SLRPs bind TGF beta	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SLRPs binding TGF-beta in extracellular region. Decorin sequesters TGF-beta in ECM.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	51	R-HSA-1878002	XYLTs transfer Xyl to core protein	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for xylose transfer to decorin core protein by XYLTs (tetrasaccharide linker biosynthesis). Decorin in Golgi during GAG chain initiation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	52	R-HSA-1889955	B3GAT dimers transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for GlcA transfer to tetrasaccharide linker by B3GAT dimers. Decorin in Golgi during GAG linker biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	53	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for Gal transfer to tetrasaccharide linker by B3GALT6. Decorin in Golgi during GAG linker assembly.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	54	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for Gal transfer to xylosyl-unit by B4GALT7 (first step of tetrasaccharide linker). Decorin in Golgi during GAG biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	55	R-HSA-1971482	CSGALNACTs transfer GalNAc to CS linker glycan	yes	reactome/R-HSA-1971482.md	CSGALNACTs transfer GalNAc to CS linker glycan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for GalNAc transfer to CS linker glycan by CSGALNACTs. Decorin in Golgi during chondroitin sulfate biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	56	R-HSA-3560802	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective B3GAT3 (JDSSDHD mutation). Decorin present in Golgi during attempted GAG biosynthesis even with defective enzyme.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	57	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective B4GALT7 (EDS progeroid type mutation). Decorin present in Golgi even with defective GAG biosynthesis enzyme.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	58	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective B3GALT6 (EDSP2/SEMDJL1 mutations). Decorin present in Golgi even with defective GAG biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	59	R-HSA-1793176	DS is cleaved from its proteoglycan	yes	reactome/R-HSA-1793176.md	DS is cleaved from its proteoglycan	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for dermatan sulfate cleavage from proteoglycan in lysosome during degradation. Decorin eventually degraded in lysosomes.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	60	R-HSA-2065233	CS is cleaved from its proteoglycan	yes	reactome/R-HSA-2065233.md	CS is cleaved from its proteoglycan	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for chondroitin sulfate cleavage from proteoglycan in lysosome during degradation. Decorin eventually degraded in lysosomes.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	61	R-HSA-1971483	CHST11,12,13,9 transfer sulfate to (4-)GalNAc	yes	reactome/R-HSA-1971483.md	CHST11,12,13,9 transfer sulfate to (4-)GalNAc	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer to GalNAc by CHST enzymes during CS/DS biosynthesis. Decorin in Golgi during GAG sulfation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	62	R-HSA-1971487	Chondroitin polymerase complex transfers GalNAc to CS chain	yes	reactome/R-HSA-1971487.md	Chondroitin polymerase complex transfers GalNAc to CS chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for GalNAc transfer to CS chain by chondroitin polymerase complex. Decorin in Golgi during CS chain elongation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	63	R-HSA-1971491	Chondroitin polymerase complex transfers GlcA to CS chain	yes	reactome/R-HSA-1971491.md	Chondroitin polymerase complex transfers GlcA to CS chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for GlcA transfer to CS chain by chondroitin polymerase complex. Decorin in Golgi during CS chain elongation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	64	R-HSA-2018659	CHST15 transfers sulfate to (6-)GalNAc-4-sulfate	yes	reactome/R-HSA-2018659.md	CHST15 transfers sulfate to (6-)GalNAc-4-sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer by CHST15 to GalNAc-4-sulfate (creating 4,6-disulfated GalNAc). Decorin in Golgi during DS biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	65	R-HSA-2018682	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains	yes	reactome/R-HSA-2018682.md	CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfate transfer to position 6 of GalNAc by CHST3/7. Decorin in Golgi during CS biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	66	R-HSA-2022061	Dermatan sulfate can be further sulfated on position 2 of iduronate	yes	reactome/R-HSA-2022061.md	Dermatan sulfate can be further sulfated on position 2 of iduronate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sulfation of iduronate (position 2) in dermatan sulfate. Decorin in Golgi during DS modification.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	67	R-HSA-3595175	Defective CHST3 does not transfer SO4(2-) to chondroitin	yes	reactome/R-HSA-3595175.md	Defective CHST3 does not transfer SO4(2-) to chondroitin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective CHST3 (SEDCJD mutation - spondyloepiphyseal dysplasia with congenital joint dislocations). Decorin present in Golgi.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	68	R-HSA-3595176	Defective CHSY1 does not transfer GalNAc to chondroitin	yes	reactome/R-HSA-3595176.md	Defective CHSY1 does not transfer GalNAc to chondroitin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective CHSY1 (TPBS mutation - Temtamy preaxial brachydactyly syndrome). Decorin present in Golgi.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	69	R-HSA-3595178	Defective CHSY1 does not transfer GlcA to chondroitin	yes	reactome/R-HSA-3595178.md	Defective CHSY1 does not transfer GlcA to chondroitin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome disease pathway for defective CHSY1 (TPBS mutation). Decorin present in Golgi during defective CS biosynthesis.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	70	R-HSA-9632033	CSGALNACTs transfer GalNAc to CS chain	yes	reactome/R-HSA-9632033.md	CSGALNACTs transfer GalNAc to CS chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for GalNAc transfer to CS chain by CSGALNACTs. Decorin in Golgi during CS chain elongation.
human	DCN	genes/human/DCN/DCN-ai-review.yaml	DCN	P07585	NCBITaxon:9606	Homo sapiens	71	R-HSA-2022056	DSPG and CSPG translocate to the lysosome for degradation	yes	reactome/R-HSA-2022056.md	DSPG and CSPG translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for DSPG/CSPG translocation to lysosome for degradation. Decorin eventually degraded in lysosomal lumen.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	71	R-HSA-1791092	Expression of DCTN1	yes	reactome/R-HSA-1791092.md	Expression of DCTN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	72	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	73	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	74	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	75	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	76	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	77	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	78	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	79	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	80	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	81	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	82	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	83	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	84	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	85	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	86	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	87	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	88	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	89	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	90	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	91	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	92	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	93	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	94	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	95	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	96	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	97	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	98	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	99	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	100	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	101	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	102	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCTN1	genes/human/DCTN1/DCTN1-ai-review.yaml	DCTN1	Q14203	NCBITaxon:9606	Homo sapiens	103	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS); dynactin is a soluble cytosolic complex that associates with microtubules, centrosomes and membranes.
human	DCX	genes/human/DCX/DCX-ai-review.yaml	DCX	O43602	NCBITaxon:9606	Homo sapiens	25	R-NUL-443772	Doublecortin binds phosphorylated neurofascin	yes	reactome/R-NUL-443772.md	Doublecortin binds phosphorylated neurofascin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (HPA immunofluorescence IDA; Reactome TAS from the neurofascin-binding event).
human	DDA1	genes/human/DDA1/DDA1-ai-review.yaml	DDA1	Q9BW61	NCBITaxon:9606	Homo sapiens	18	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDA1 nucleoplasmic localization within a CRL4 neddylation reaction. Consistent with the nuclear site of CRL4 action.
human	DDA1	genes/human/DDA1/DDA1-ai-review.yaml	DDA1	Q9BW61	NCBITaxon:9606	Homo sapiens	19	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDA1 nucleoplasmic localization within a CRL4 neddylation reaction.
human	DDA1	genes/human/DDA1/DDA1-ai-review.yaml	DDA1	Q9BW61	NCBITaxon:9606	Homo sapiens	20	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDA1 nucleoplasmic localization within a CRL4 regulation reaction (CAND1 binds CRL4).
human	DDA1	genes/human/DDA1/DDA1-ai-review.yaml	DDA1	Q9BW61	NCBITaxon:9606	Homo sapiens	21	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDA1 nucleoplasmic localization within a CRL4 regulation reaction (COMMDs displace CAND1).
human	DDA1	genes/human/DDA1/DDA1-ai-review.yaml	DDA1	Q9BW61	NCBITaxon:9606	Homo sapiens	22	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDA1 nucleoplasmic localization within a CRL4 regulation reaction (COP9 signalosome deneddylates CRL4).
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	161	R-HSA-5652005	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	yes	reactome/R-HSA-5652005.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	162	R-HSA-5652009	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	yes	reactome/R-HSA-5652009.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	163	R-HSA-5689317	Formation of the pre-incision complex in GG-NER	yes	reactome/R-HSA-5689317.md	Formation of the pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	164	R-HSA-5689861	Recruitment of XPA and release of CAK	yes	reactome/R-HSA-5689861.md	Recruitment of XPA and release of CAK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	165	R-HSA-5690213	DNA polymerases delta, epsilon or kappa bind the GG-NER site	yes	reactome/R-HSA-5690213.md	DNA polymerases delta, epsilon or kappa bind the GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	166	R-HSA-5690988	3'-incision of DNA by ERCC5 (XPG) in GG-NER	yes	reactome/R-HSA-5690988.md	3'-incision of DNA by ERCC5 (XPG) in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	167	R-HSA-5690990	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	yes	reactome/R-HSA-5690990.md	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	168	R-HSA-5690991	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	yes	reactome/R-HSA-5690991.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	169	R-HSA-5690996	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	yes	reactome/R-HSA-5690996.md	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	170	R-HSA-5691000	TFIIH binds GG-NER site to form a verification complex	yes	reactome/R-HSA-5691000.md	TFIIH binds GG-NER site to form a verification complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	171	R-HSA-5691006	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	yes	reactome/R-HSA-5691006.md	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	172	R-HSA-5696655	PARP1 or PARP2 PARylates DDB2 and autoPARylates	yes	reactome/R-HSA-5696655.md	PARP1 or PARP2 PARylates DDB2 and autoPARylates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	173	R-HSA-5696664	PARP1 or PARP2 binds DDB2 at GG-NER site	yes	reactome/R-HSA-5696664.md	PARP1 or PARP2 binds DDB2 at GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	174	R-HSA-5696670	CHD1L is recruited to GG-NER site	yes	reactome/R-HSA-5696670.md	CHD1L is recruited to GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	175	R-HSA-6781833	ERCC8 (CSA) binds stalled RNA Pol II	yes	reactome/R-HSA-6781833.md	ERCC8 (CSA) binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	176	R-HSA-6781867	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	yes	reactome/R-HSA-6781867.md	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	177	R-HSA-6782004	Assembly of the pre-incision complex in TC-NER	yes	reactome/R-HSA-6782004.md	Assembly of the pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	178	R-HSA-6782069	UVSSA:USP7 deubiquitinates ERCC6	yes	reactome/R-HSA-6782069.md	UVSSA:USP7 deubiquitinates ERCC6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	179	R-HSA-6782131	ERCC2-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-6782131.md	ERCC2-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	180	R-HSA-6782138	ERCC5 and RPA bind TC-NER site	yes	reactome/R-HSA-6782138.md	ERCC5 and RPA bind TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	181	R-HSA-6782141	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	yes	reactome/R-HSA-6782141.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	182	R-HSA-6782204	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	yes	reactome/R-HSA-6782204.md	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	183	R-HSA-6782208	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	yes	reactome/R-HSA-6782208.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	184	R-HSA-6782211	DNA polymerases delta, epsilon or kappa bind the TC-NER site	yes	reactome/R-HSA-6782211.md	DNA polymerases delta, epsilon or kappa bind the TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	185	R-HSA-6782224	3' incision by ERCC5 (XPG) in TC-NER	yes	reactome/R-HSA-6782224.md	3' incision by ERCC5 (XPG) in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	186	R-HSA-6782227	Ligation of newly synthesized repair patch to incised DNA in TC-NER	yes	reactome/R-HSA-6782227.md	Ligation of newly synthesized repair patch to incised DNA in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	187	R-HSA-6782234	Recovery of RNA synthesis after TC-NER	yes	reactome/R-HSA-6782234.md	Recovery of RNA synthesis after TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	188	R-HSA-6782943	UV-DDB ubiquitinates XPC	yes	reactome/R-HSA-6782943.md	UV-DDB ubiquitinates XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	189	R-HSA-6790454	SUMOylation of XPC	yes	reactome/R-HSA-6790454.md	SUMOylation of XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	190	R-HSA-6790487	RNF111 ubiquitinates SUMOylated XPC	yes	reactome/R-HSA-6790487.md	RNF111 ubiquitinates SUMOylated XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	191	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	192	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	193	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	194	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	195	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB1	genes/human/DDB1/DDB1-ai-review.yaml	DDB1	Q16531	NCBITaxon:9606	Homo sapiens	196	R-HSA-9684118	ERCC3-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-9684118.md	ERCC3-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization (Reactome/IDA), a sub-compartment consistent with nuclear CRL4/NER activity.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	48	R-HSA-5696997	USP24 deubiquitinates DDB2	yes	reactome/R-HSA-5696997.md	USP24 deubiquitinates DDB2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization within a GG-NER/CRL4 reaction (USP24 deubiquitinates DDB2). Consistent with the core nuclear compartment.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	49	R-HSA-5689317	Formation of the pre-incision complex in GG-NER	yes	reactome/R-HSA-5689317.md	Formation of the pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in GG-NER pre-incision complex formation.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	50	R-HSA-5689861	Recruitment of XPA and release of CAK	yes	reactome/R-HSA-5689861.md	Recruitment of XPA and release of CAK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (XPA recruitment).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	51	R-HSA-5690213	DNA polymerases delta, epsilon or kappa bind the GG-NER site	yes	reactome/R-HSA-5690213.md	DNA polymerases delta, epsilon or kappa bind the GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	52	R-HSA-5690988	3'-incision of DNA by ERCC5 (XPG) in GG-NER	yes	reactome/R-HSA-5690988.md	3'-incision of DNA by ERCC5 (XPG) in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER incision reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	53	R-HSA-5690990	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	yes	reactome/R-HSA-5690990.md	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER incision reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	54	R-HSA-5690991	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	yes	reactome/R-HSA-5690991.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	55	R-HSA-5690996	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	yes	reactome/R-HSA-5690996.md	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	56	R-HSA-5691000	TFIIH binds GG-NER site to form a verification complex	yes	reactome/R-HSA-5691000.md	TFIIH binds GG-NER site to form a verification complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	57	R-HSA-5696655	PARP1 or PARP2 PARylates DDB2 and autoPARylates	yes	reactome/R-HSA-5696655.md	PARP1 or PARP2 PARylates DDB2 and autoPARylates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (PARP1/2 PARylates DDB2).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	58	R-HSA-5696670	CHD1L is recruited to GG-NER site	yes	reactome/R-HSA-5696670.md	CHD1L is recruited to GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (CHD1L recruitment).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	59	R-HSA-6790454	SUMOylation of XPC	yes	reactome/R-HSA-6790454.md	SUMOylation of XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER/XPC SUMOylation reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	60	R-HSA-6790487	RNF111 ubiquitinates SUMOylated XPC	yes	reactome/R-HSA-6790487.md	RNF111 ubiquitinates SUMOylated XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (RNF111 ubiquitinates SUMOylated XPC).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	63	R-HSA-5691006	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	yes	reactome/R-HSA-5691006.md	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	64	R-HSA-5696664	PARP1 or PARP2 binds DDB2 at GG-NER site	yes	reactome/R-HSA-5696664.md	PARP1 or PARP2 binds DDB2 at GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a GG-NER reaction (PARP1/2 binds DDB2).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	65	R-HSA-6782943	UV-DDB ubiquitinates XPC	yes	reactome/R-HSA-6782943.md	UV-DDB ubiquitinates XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in the GG-NER reaction in which UV-DDB ubiquitinates XPC.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	66	R-HSA-6806423	TP53 stimulates DDB2 expression	yes	reactome/R-HSA-6806423.md	TP53 stimulates DDB2 expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in the reaction TP53 stimulates DDB2 expression.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	67	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a CRL4 neddylation reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	68	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a CRL4 neddylation reaction.
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	69	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a CRL4 regulation reaction (CAND1 binds CRL4).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	70	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a CRL4 regulation reaction (COMMDs displace CAND1).
human	DDB2	genes/human/DDB2/DDB2-ai-review.yaml	DDB2	Q92466	NCBITaxon:9606	Homo sapiens	71	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DDB2 nucleoplasmic localization in a CRL4 regulation reaction (COP9 signalosome deneddylates CRL4).
human	DDC	genes/human/DDC/DDC-ai-review.yaml	DDC	P20711	NCBITaxon:9606	Homo sapiens	24	R-HSA-209859	Decarboxylation of 5-hydroxytryptophan forms serotonin	yes	reactome/R-HSA-209859.md	Decarboxylation of 5-hydroxytryptophan forms serotonin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core localization. AADC acts as a cytosolic homodimer; Reactome places the serotonin-forming decarboxylation reaction in the cytosol. Consistent with the IBA cytoplasm annotation.
human	DDC	genes/human/DDC/DDC-ai-review.yaml	DDC	P20711	NCBITaxon:9606	Homo sapiens	25	R-HSA-209924	Dopa is decarboxylated to dopamine	yes	reactome/R-HSA-209924.md	Dopa is decarboxylated to dopamine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core localization (duplicate of the other Reactome cytosol annotation, from the dopamine-forming reaction). AADC is a cytosolic enzyme. Accept.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	24	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation (azurophil granule exocytosis) inclusion. This reflects large-scale granule-proteome cataloguing rather than the site of DDOST's molecular function, which is the ER membrane. Not a core location; marked as over-annotated.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	26	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane (Transfer of N-glycan to the protein reaction). Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	27	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for a pathway-specific N-glycosylation reaction (SARS-CoV-2 spike glycosylation). Correct core location; pathway context is substrate-specific but the location is right.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	28	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for CDH1 N-glycosylation. Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	29	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for a viral (dengue E) N-glycosylation reaction. Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	30	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for a viral (pre-M) N-glycosylation reaction. Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	31	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for a viral (pre-NS1) N-glycosylation reaction. Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	32	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS to ER membrane for CD274/PD-L1 N-glycosylation. Correct core location.
human	DDOST	genes/human/DDOST/DDOST-ai-review.yaml	DDOST	P39656	NCBITaxon:9606	Homo sapiens	33	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome plasma-membrane annotation from the azurophil-granule exocytosis pathway (granule membrane proteins reaching the cell surface upon degranulation). This is not DDOST's functional location; DDOST acts in the ER membrane. Marked as over-annotated.
human	DEGS1	genes/human/DEGS1/DEGS1-ai-review.yaml	DEGS1	O15121	NCBITaxon:9606	Homo sapiens	13	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (Sphingolipid de novo biosynthesis) traceable assertion that DEGS1 acts in sphingolipid biosynthesis. Correct and consistent with the accepted BP.
human	DEGS1	genes/human/DEGS1/DEGS1-ai-review.yaml	DEGS1	O15121	NCBITaxon:9606	Homo sapiens	14	R-HSA-428259	DEGS1 dehydrogenates dihydroceramide	yes	reactome/R-HSA-428259.md	DEGS1 dehydrogenates dihydroceramide	Homo sapiens	GO:0042284	sphingolipid delta-4 desaturase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of the core desaturase reaction (DEGS1 dehydrogenates dihydroceramide). Correct core molecular function.
human	DEGS1	genes/human/DEGS1/DEGS1-ai-review.yaml	DEGS1	O15121	NCBITaxon:9606	Homo sapiens	33	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Plasma membrane localization from a Reactome neutrophil-degranulation pathway (specific granule exocytosis). This reflects bulk granule/membrane proteomics, not a functional DEGS1 site; DEGS1 acts at the ER, not the plasma membrane.
human	DEGS1	genes/human/DEGS1/DEGS1-ai-review.yaml	DEGS1	O15121	NCBITaxon:9606	Homo sapiens	34	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Specific granule membrane localization from the same neutrophil-degranulation pathway. Reflects granule-membrane proteomics rather than a functional DEGS1 location.
human	DEGS1	genes/human/DEGS1/DEGS1-ai-review.yaml	DEGS1	O15121	NCBITaxon:9606	Homo sapiens	35	R-HSA-428259	DEGS1 dehydrogenates dihydroceramide	yes	reactome/R-HSA-428259.md	DEGS1 dehydrogenates dihydroceramide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of ER membrane localization for the DEGS1 desaturation reaction. Correct core localization.
human	DGAT1	genes/human/DGAT1/DGAT1-ai-review.yaml	DGAT1	O75907	NCBITaxon:9606	Homo sapiens	37	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"From the Reactome neutrophil-degranulation (""Exocytosis of specific granule membrane proteins"") pathway. DGAT1 is an ER-membrane enzyme; plasma-membrane localization is not its physiological site of action and is an over-annotation."
human	DGAT1	genes/human/DGAT1/DGAT1-ai-review.yaml	DGAT1	O75907	NCBITaxon:9606	Homo sapiens	38	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	From the same Reactome neutrophil-degranulation pathway. Specific granule membrane is not the physiological location of this ER enzyme; over-annotation.
human	DGAT1	genes/human/DGAT1/DGAT1-ai-review.yaml	DGAT1	O75907	NCBITaxon:9606	Homo sapiens	45	R-HSA-1482889	DAG is acylated to TAG by DGAT1/2	yes	reactome/R-HSA-1482889.md	DAG is acylated to TAG by DGAT1/2	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the ER-membrane location (DAG-to-TAG acylation reaction). Correct core location.
human	DGAT1	genes/human/DGAT1/DGAT1-ai-review.yaml	DGAT1	O75907	NCBITaxon:9606	Homo sapiens	46	R-HSA-75900	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]	yes	reactome/R-HSA-75900.md	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS for the ER-membrane location, from the reaction ""1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]"". Correct core location."
human	DGAT2	genes/human/DGAT2/DGAT2-ai-review.yaml	DGAT2	Q96PD7	NCBITaxon:9606	Homo sapiens	33	R-HSA-75109	Triglyceride biosynthesis	yes	reactome/R-HSA-75109.md	Triglyceride biosynthesis	Homo sapiens	GO:0019432	triglyceride biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted participation in triglyceride biosynthesis, the core process for DGAT2. Concordant with the IDA and IBA annotations.
human	DGAT2	genes/human/DGAT2/DGAT2-ai-review.yaml	DGAT2	Q96PD7	NCBITaxon:9606	Homo sapiens	63	R-HSA-1482889	DAG is acylated to TAG by DGAT1/2	yes	reactome/R-HSA-1482889.md	DAG is acylated to TAG by DGAT1/2	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization; concordant with the experimental IDA/IC.
human	DGAT2	genes/human/DGAT2/DGAT2-ai-review.yaml	DGAT2	Q96PD7	NCBITaxon:9606	Homo sapiens	64	R-HSA-549192	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]	yes	reactome/R-HSA-549192.md	1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization from the DGAT2 TAG-synthesis reaction; concordant with experimental evidence.
human	DGUOK	genes/human/DGUOK/DGUOK-ai-review.yaml	DGUOK	Q16854	NCBITaxon:9606	Homo sapiens	27	R-HSA-74207	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)	yes	reactome/R-HSA-74207.md	dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the mitochondrial matrix, the most specific and correct compartment for DGUOK, where purine deoxyribonucleoside salvage occurs.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	18	R-HSA-191273	Cholesterol biosynthesis	yes	reactome/R-HSA-191273.md	Cholesterol biosynthesis	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	TAS annotation from Reactome for cholesterol biosynthetic process. This is a core function of DHCR24 as the terminal enzyme in cholesterol biosynthesis.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	19	R-HSA-6807047	Cholesterol biosynthesis via desmosterol	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0033489	cholesterol biosynthetic process via desmosterol	TAS	involved_in	BP	false		MODIFY	TAS annotation from Reactome for cholesterol biosynthesis via desmosterol. This is the primary pathway where DHCR24 functions, converting desmosterol to cholesterol in the Bloch pathway.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	20	R-HSA-6807062	Cholesterol biosynthesis via lathosterol	yes	reactome/R-HSA-6807062.md	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	Homo sapiens	GO:0033490	cholesterol biosynthetic process via lathosterol	TAS	involved_in	BP	false		MODIFY	TAS annotation from Reactome for cholesterol biosynthesis via lathosterol (Kandutsch-Russell pathway). DHCR24 can act on various sterol intermediates including those in this alternate pathway.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	33	R-HSA-9755937	DHCR24 reduces LAN to 24,25-dhLAN	no				GO:0050614	Delta24-sterol reductase activity	TAS	enables	MF	false		ACCEPT	TAS annotation from Reactome for Delta24-sterol reductase activity, specifically for lanosterol reduction. This is a validated core molecular function of DHCR24.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	39	R-HSA-196417	Reduction of desmosterol to cholesterol	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for ER membrane localization. This is the correct primary localization where DHCR24 performs its enzymatic function.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807064	DHCR24 reduces ZYMOL to ZYMSTNL	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Another TAS annotation from Reactome for ER membrane. This is a duplicate but correct annotation for the primary cellular localization.
human	DHCR24	genes/human/DHCR24/DHCR24-ai-review.yaml	DHCR24	Q15392	NCBITaxon:9606	Homo sapiens	41	R-HSA-9755937	DHCR24 reduces LAN to 24,25-dhLAN	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Another TAS annotation from Reactome for ER membrane. Multiple Reactome pathways correctly place DHCR24 at the ER membrane.
human	DHCR7	genes/human/DHCR7/DHCR7-ai-review.yaml	DHCR7	Q9UBM7	NCBITaxon:9606	Homo sapiens	9	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Cholesterol biosynthetic process, asserted via the Reactome Bloch-pathway (via desmosterol) module.
human	DHCR7	genes/human/DHCR7/DHCR7-ai-review.yaml	DHCR7	Q9UBM7	NCBITaxon:9606	Homo sapiens	10	R-HSA-9969901	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	yes	reactome/R-HSA-9969901.md	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Cholesterol biosynthetic process, asserted via the Reactome modified Kandutsch-Russell (from zymosterol) module - the arm terminated by DHCR7.
human	DHCR7	genes/human/DHCR7/DHCR7-ai-review.yaml	DHCR7	Q9UBM7	NCBITaxon:9606	Homo sapiens	25	R-HSA-1655827	Expression of 7-Dehydrocholesterol Reductase (DHCR7)	yes	reactome/R-HSA-1655827.md	Expression of 7-Dehydrocholesterol Reductase (DHCR7)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization asserted by Reactome.
human	DHCR7	genes/human/DHCR7/DHCR7-ai-review.yaml	DHCR7	Q9UBM7	NCBITaxon:9606	Homo sapiens	26	R-HSA-196402	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol	yes	reactome/R-HSA-196402.md	Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization asserted by Reactome.
human	DHCR7	genes/human/DHCR7/DHCR7-ai-review.yaml	DHCR7	Q9UBM7	NCBITaxon:9606	Homo sapiens	27	R-HSA-6807055	DHCR7 reduces 7-dehydroCHOL to CHOL	yes	reactome/R-HSA-6807055.md	DHCR7 reduces 7-dehydroCHOL to CHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization asserted by the Reactome reaction 'DHCR7 reduces 7-dehydroCHOL to CHOL'.
human	DHDDS	genes/human/DHDDS/DHDDS-ai-review.yaml	DHDDS	Q86SQ9	NCBITaxon:9606	Homo sapiens	22	R-HSA-4755545	Defective DHDDS does not elongate E,E-FPP	yes	reactome/R-HSA-4755545.md	Defective DHDDS does not elongate E,E-FPP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane localization asserted by Reactome, consistent with experimental evidence. Redundant with the IDA (PMID:14652022) but records the gene's own correct compartment; accepted.
human	DHDDS	genes/human/DHDDS/DHDDS-ai-review.yaml	DHDDS	Q86SQ9	NCBITaxon:9606	Homo sapiens	23	R-HSA-4419978	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP	yes	reactome/R-HSA-4419978.md	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane localization asserted by Reactome (DHDDS:NUS1 elongation reaction), consistent with the experimentally determined location. Accepted.
human	DHODH	genes/human/DHODH/DHODH-ai-review.yaml	DHODH	Q02127	NCBITaxon:9606	Homo sapiens	22	R-HSA-73569	DHODH:FMN oxidises (S)-DHO to orotate	yes	reactome/R-HSA-73569.md	DHODH:FMN oxidises (S)-DHO to orotate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway curation. Reactome reaction R-HSA-73569 represents ""DHODH:FMN oxidises (S)-DHO to orotate"" occurring at the inner mitochondrial membrane."
human	DHODH	genes/human/DHODH/DHODH-ai-review.yaml	DHODH	Q02127	NCBITaxon:9606	Homo sapiens	23	R-HSA-9708759	DHODH:FMN binds DHODH inhibitors	yes	reactome/R-HSA-9708759.md	DHODH:FMN binds DHODH inhibitors	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for DHODH inhibitor binding. This Reactome entry covers pharmacological targeting of DHODH at the inner membrane.
human	DHRS3	genes/human/DHRS3/DHRS3-ai-review.yaml	DHRS3	O75911	NCBITaxon:9606	Homo sapiens	8	R-HSA-2187335	The retinoid cycle in cones (daylight vision)	yes	reactome/R-HSA-2187335.md	The retinoid cycle in cones (daylight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Correct pathway-level process term, supported by the Reactome retinoid-cycle pathway. Consistent with DHRS3's retinaldehyde-reductase activity in retinoid metabolism; broader than retinol metabolic process. Accept.
human	DHRS3	genes/human/DHRS3/DHRS3-ai-review.yaml	DHRS3	O75911	NCBITaxon:9606	Homo sapiens	9	R-HSA-2465940	atRAL is reduced to atROL	yes	reactome/R-HSA-2465940.md	atRAL is reduced to atROL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	Core molecular function, curated by Reactome (atRAL is reduced to atROL using NADP+/NADPH). Consistent with UniProt EC 1.1.1.300. Accept.
human	DHRS3	genes/human/DHRS3/DHRS3-ai-review.yaml	DHRS3	O75911	NCBITaxon:9606	Homo sapiens	10	R-HSA-5419165	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	yes	reactome/R-HSA-5419165.md	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	Core molecular function, curated by Reactome (DHRS3 among reductases that reduce atRAL to atROL). Consistent with the NADP+ reaction in UniProt. Accept.
human	DHRS3	genes/human/DHRS3/DHRS3-ai-review.yaml	DHRS3	O75911	NCBITaxon:9606	Homo sapiens	12	R-HSA-5419165	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	yes	reactome/R-HSA-5419165.md	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct and the informative core localization: DHRS3 is a multi-pass membrane protein that functions in a complex with RDH10 inserted in the endoplasmic reticulum membrane. Accept.
human	DHRS3	genes/human/DHRS3/DHRS3-ai-review.yaml	DHRS3	O75911	NCBITaxon:9606	Homo sapiens	13	R-HSA-2465940	atRAL is reduced to atROL	yes	reactome/R-HSA-2465940.md	atRAL is reduced to atROL	Homo sapiens	GO:0042622	photoreceptor outer segment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retina-specific localization from the visual (retinoid) cycle; consistent with DHRS3 being expressed in cone outer segments. This is a tissue-specific context rather than the general (ER membrane) localization, so it is kept as non-core.
human	DHTKD1	genes/human/DHTKD1/DHTKD1-ai-review.yaml	DHTKD1	Q96HY7	NCBITaxon:9606	Homo sapiens	15	R-HSA-9858321	DHTKD1 dimer decarboxylates 2-OA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the DHTKD1-catalyzed 2-oxoadipate decarboxylation to the mitochondrial matrix, the compartment of the OADHC.
human	DHTKD1	genes/human/DHTKD1/DHTKD1-ai-review.yaml	DHTKD1	Q96HY7	NCBITaxon:9606	Homo sapiens	16	R-HSA-9858589	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the OADHC E3 (DLD) dihydrolipoyl dehydrogenation step to the mitochondrial matrix, the compartment where DHTKD1 acts.
human	DHTKD1	genes/human/DHTKD1/DHTKD1-ai-review.yaml	DHTKD1	Q96HY7	NCBITaxon:9606	Homo sapiens	17	R-HSA-9858590	DLST transfers glutaryl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the OADHC E2 (DLST) glutaryl transfer to CoA in the mitochondrial matrix, the compartment where DHTKD1 acts.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	19	R-HSA-9861559	PDH complex synthesizes acetyl-CoA from PYR	no				GO:0006086	pyruvate decarboxylation to acetyl-CoA	TAS	involved_in	BP	false		ACCEPT	Reactome TAS for the overall PDC reaction that synthesizes acetyl-CoA from pyruvate. Core process for DLAT as the E2 component.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	20	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the DLAT-catalyzed transfer of the acetyl group from acetyllipoyl-lysine to CoA. This is the defining E2 reaction.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	30	R-HSA-203946	PDK isozymes phosphorylate PDHC subunit E1	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (PDK phosphorylation of the PDC subunit E1 reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	31	R-HSA-204169	PDP1,2 dephosphorylate p-lipo-PDH	yes	reactome/R-HSA-204169.md	PDP1,2 dephosphorylate p-lipo-PDH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (PDP dephosphorylation reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	32	R-HSA-9858752	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT	yes	reactome/R-HSA-9858752.md	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (LIPT1 lipoyl transfer to DLAT reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	33	R-HSA-9861616	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (DLD dehydrogenation of dihydrolipoyl reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	34	R-HSA-9861626	SIRT4 cleaves lipoyl from DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (SIRT4 delipoylation of DLAT reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	35	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (DLAT acetyl transfer to CoA reaction). Correct specific compartment.
human	DLAT	genes/human/DLAT/DLAT-ai-review.yaml	DLAT	P10515	NCBITaxon:9606	Homo sapiens	36	R-HSA-9861734	PDH E1 decarboxylates PYR, transferring acetyl to DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing DLAT in the mitochondrial matrix (E1 decarboxylation transferring acetyl to DLAT reaction). Correct specific compartment.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	60	R-HSA-203946	PDK isozymes phosphorylate PDHC subunit E1	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	61	R-HSA-204169	PDP1,2 dephosphorylate p-lipo-PDH	yes	reactome/R-HSA-204169.md	PDP1,2 dephosphorylate p-lipo-PDH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	62	R-HSA-5693148	BCKDK phosphorylates BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	63	R-HSA-5693153	PPM1K dephosphorylates p-BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	64	R-HSA-5694018	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	yes	reactome/R-HSA-5694018.md	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	65	R-HSA-71401	OGDH dimer decarboxylates 2-OG	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	66	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	67	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	68	R-HSA-9853499	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	69	R-HSA-9853512	DLST transfers succinyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	70	R-HSA-9858321	DHTKD1 dimer decarboxylates 2-OA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	71	R-HSA-9858589	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	72	R-HSA-9858590	DLST transfers glutaryl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	73	R-HSA-9859148	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	74	R-HSA-9859163	DBT transfers BCAA to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	75	R-HSA-9859172	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	76	R-HSA-9861616	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	77	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	78	R-HSA-9861734	PDH E1 decarboxylates PYR, transferring acetyl to DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	79	R-HSA-9865115	DBT loss-of-function mutants don't synthesize BCAA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	80	R-HSA-9912480	BCKDK loss-of-function mutations do not phosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	81	R-HSA-9912527	H139Hfs13* PPM1K does not dephosphorylate BCKDH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing DLD (E3 dimer) in the mitochondrial matrix within curated 2-oxoacid dehydrogenase / glycine-cleavage reactions. Consistent with the established primary localization.
human	DLD	genes/human/DLD/DLD-ai-review.yaml	DLD	P09622	NCBITaxon:9606	Homo sapiens	84	R-HSA-5694018	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	yes	reactome/R-HSA-5694018.md	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	Homo sapiens	GO:0019464	glycine decarboxylation via glycine cleavage system	TAS	involved_in	BP	false		NEW	DLD is the L protein of the mitochondrial glycine cleavage system. It catalyses the final step of the cycle, reoxidising the dihydrolipoyl group on the H protein (GCSH) and passing the electrons to NAD+, which regenerates the lipoylated H protein for the next round of glycine decarboxylation.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	22	R-HSA-9858321	DHTKD1 dimer decarboxylates 2-OA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to the 2-oxoadipate dehydrogenase (DHTKD1) decarboxylation reaction, where DLST acts as the E2 of the OADHC. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	23	R-HSA-9858590	DLST transfers glutaryl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to the reaction in which DLST transfers the glutaryl group to CoA in the OADHC. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	24	R-HSA-71401	OGDH dimer decarboxylates 2-OG	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to the OGDH-catalyzed decarboxylation of 2-oxoglutarate within the OGDH complex. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	25	R-HSA-9853499	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to the DLD-catalyzed re-oxidation of the dihydrolipoyl arm within the OGDH complex. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	26	R-HSA-9853512	DLST transfers succinyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization for the reaction in which DLST transfers the succinyl group to CoA within the OGDH complex. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	27	R-HSA-9858589	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to the DLD-catalyzed re-oxidation step in the OADHC. The matrix is the correct core localization.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	37	R-HSA-5694018	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	yes	reactome/R-HSA-5694018.md	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to a lipoyl/glycine- cleavage-system oxidation reaction. The matrix is the correct core localization for DLST.
human	DLST	genes/human/DLST/DLST-ai-review.yaml	DLST	P36957	NCBITaxon:9606	Homo sapiens	38	R-HSA-6792572	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	yes	reactome/R-HSA-6792572.md	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial-matrix localization tied to LIPT1-mediated lipoyl transfer onto DBT/DLST (lipoylation of the E2 lipoyl domain). The matrix is the correct core localization for DLST.
human	DNAJA2	genes/human/DNAJA2/DNAJA2-ai-review.yaml	DNAJA2	O60884	NCBITaxon:9606	Homo sapiens	25	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation of GO:0005829 (cytosol) from Reactome pathway R-HSA-3371422 (ATP hydrolysis by HSP70). DNAJA2 is placed in the cytosol as part of the HSP70 chaperone cycle where J domain co-chaperones stimulate HSP70 ATPase activity. This is consistent with all other evidence for cytosolic localization.
human	DNAJA2	genes/human/DNAJA2/DNAJA2-ai-review.yaml	DNAJA2	O60884	NCBITaxon:9606	Homo sapiens	26	R-HSA-3371503	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation of GO:0005829 (cytosol) from Reactome pathway R-HSA-3371503 (STIP1 (HOP) binds HSP90 and HSP70:HSP40:nascent protein). DNAJA2 is placed in the cytosol as part of the HSP70:HSP40:nascent protein complex that is bridged to HSP90 by STIP1/HOP. Consistent with all other evidence for cytosolic localization.
human	DNAJA2	genes/human/DNAJA2/DNAJA2-ai-review.yaml	DNAJA2	O60884	NCBITaxon:9606	Homo sapiens	27	R-HSA-3371590	HSP70 binds to HSP40:nascent protein	yes	reactome/R-HSA-3371590.md	HSP70 binds to HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation of GO:0005829 (cytosol) from Reactome pathway R-HSA-3371590 (HSP70 binds to HSP40:nascent protein). DNAJA2 is placed in the cytosol as the HSP40 co-chaperone that first binds nascent/unfolded client proteins before delivering them to HSP70. Consistent with all other evidence.
human	DNAJA4	genes/human/DNAJA4/DNAJA4-ai-review.yaml	DNAJA4	Q8WW22	NCBITaxon:9606	Homo sapiens	23	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization from Reactome pathway R-HSA-3371422 (ATP hydrolysis by HSP70). The Reactome entry describes the HSP70 chaperone cycle in which HSP40 co-chaperones (including DNAJA4) stimulate HSP70 ATPase activity in the cytosol. This localization is independently confirmed by IDA evidence from PMID:21231916 and IBA evidence from GO_REF:0000033.
human	DNAJA4	genes/human/DNAJA4/DNAJA4-ai-review.yaml	DNAJA4	Q8WW22	NCBITaxon:9606	Homo sapiens	24	R-HSA-3371503	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization from Reactome pathway R-HSA-3371503 (STIP1/HOP binds HSP90 and HSP70:HSP40:nascent protein). The Reactome entry describes the HSP70-HSP40-HOP-HSP90 relay pathway in the cytosol, in which DNAJA4 participates as a HSP40 co-chaperone. This localization is independently confirmed by IDA (PMID:21231916) and IBA evidence.
human	DNAJA4	genes/human/DNAJA4/DNAJA4-ai-review.yaml	DNAJA4	Q8WW22	NCBITaxon:9606	Homo sapiens	25	R-HSA-3371590	HSP70 binds to HSP40:nascent protein	yes	reactome/R-HSA-3371590.md	HSP70 binds to HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization from Reactome pathway R-HSA-3371590 (HSP70 binds to HSP40:nascent protein). The Reactome entry describes the initial step of client protein binding by HSP40 co-chaperones followed by HSP70 recruitment in the cytosol. DNAJA4 is included as one of the HSP40 family members. This localization is independently confirmed by IDA and IBA evidence.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	35	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		ACCEPT	Reactome R-HSA-3371453 models the regulation of HSF1-mediated heat shock response. DNAJB1 participates in this pathway by repressing HSF1 transcriptional activity together with HSP70 during the attenuation phase (PMID:9499401).
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	41	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	Reactome R-HSA-5251955 models HSP40s activating intrinsic ATPase activity of HSP70s in the nucleoplasm. DNAJB1 translocates to the nucleus under heat shock and activates HSP70 ATPase activity there.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	42	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	Reactome R-HSA-5251959 models HSP40s activating intrinsic ATPase activity of HSP70s in the cytosol. DNAJB1 is explicitly listed as one of the HSP40s that modulates intrinsic ATPase activity of HSP70s.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	53	R-HSA-5690250	p-T182-MAPKAPK5 phoshphorylates DNAJB1	yes	reactome/R-HSA-5690250.md	p-T182-MAPKAPK5 phoshphorylates DNAJB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5690250 describes phosphorylation of DNAJB1 by MAPKAPK5 in the cytosol. Cytosolic localization of DNAJB1 is well-established and this Reactome annotation is consistent.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	59	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-3371467 models SIRT1 deacetylation of HSF1. DNAJB1 is included in this pathway as part of the HSF1 regulatory complex in the nucleoplasm.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	60	R-HSA-3371518	SIRT1 binds to HSF1	yes	reactome/R-HSA-3371518.md	SIRT1 binds to HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-3371518 models SIRT1 binding to HSF1. DNAJB1 participates in the nucleoplasmic HSF1 regulatory complex.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	61	R-HSA-3371554	HSF1 acetylation at Lys80	yes	reactome/R-HSA-3371554.md	HSF1 acetylation at Lys80	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-3371554 models HSF1 acetylation at Lys80. DNAJB1 participates in this HSF1 regulatory pathway in the nucleoplasm.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	62	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5082356 models HSF1-mediated gene expression. DNAJB1 is placed in the nucleoplasm as part of the HSF1 attenuation mechanism.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	63	R-HSA-5082369	Acetylated HSF1 dissociates from DNA	yes	reactome/R-HSA-5082369.md	Acetylated HSF1 dissociates from DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5082369 models acetylated HSF1 dissociation from DNA. DNAJB1 is part of the HSF1 attenuation complex in the nucleoplasm.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	64	R-HSA-5082384	HSP70:DNAJB1 binds HSF1	yes	reactome/R-HSA-5082384.md	HSP70:DNAJB1 binds HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5082384 specifically models HSP70:DNAJB1 binding HSF1 in the nucleoplasm. Shi et al. (PMID:9499401) showed that Hsp70 and Hdj1 interact with the HSF1 activation domain and repress transcription.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	65	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5251955 models HSP40s activating HSP70 ATPase activity in the nucleoplasm. DNAJB1 is explicitly listed as one of the HSP40s that stimulates HSP70 ATPase activity in this compartment.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	67	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5251959 models HSP40s activating HSP70 ATPase activity in the cytosol. DNAJB1 is one of the HSP40s that activates HSP70 ATPase in the cytosol.
human	DNAJB1	genes/human/DNAJB1/DNAJB1-ai-review.yaml	DNAJB1	P25685	NCBITaxon:9606	Homo sapiens	68	R-HSA-5690245	p-T182 MAPKAPK5 binds DNAJB1	yes	reactome/R-HSA-5690245.md	p-T182 MAPKAPK5 binds DNAJB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-5690245 models the binding of phosphorylated MAPKAPK5 to DNAJB1 in the cytosol. Cytosolic localization is consistent with known DNAJB1 biology.
human	DNAJB11	genes/human/DNAJB11/DNAJB11-ai-review.yaml	DNAJB11	Q9UBS4	NCBITaxon:9606	Homo sapiens	27	R-HSA-1791075	Reactome pathway annotation (ER lumen localization of DNAJB11/ERdj3)	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome-curated ER-lumen localization, consistent with the precise, experimentally established compartment.
human	DNAJB6	genes/human/DNAJB6/DNAJB6-ai-review.yaml	DNAJB6	O75190	NCBITaxon:9606	Homo sapiens	23	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	This TAS annotation from Reactome (R-HSA-3371453, Regulation of HSF1-mediated heat shock response) places DNAJB6 in the heat shock response pathway. As a DnaJ/Hsp40 co-chaperone, DNAJB6 participates in the Hsp70 chaperone network that is central to the cellular heat shock response. The Reactome pathway describes how chaperones regulate HSF1 activity. This is a legitimate biological process for DNAJB6 but represents a broader pathway context rather than a core specific function.
human	DNAJB6	genes/human/DNAJB6/DNAJB6-ai-review.yaml	DNAJB6	O75190	NCBITaxon:9606	Homo sapiens	25	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	This TAS annotation from Reactome (R-HSA-5251955, HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm) correctly identifies DNAJB6 as an activator of HSP70 ATPase activity. The Reactome pathway summary explicitly lists DNAJB6 (as DNAJB6) among the HSP40s that stimulate HSP70 ATPase activity, citing Izawa et al. 2000 (PMID:10954706) and Hanai & Mashima 2003. This is a core molecular function of all J-domain proteins.
human	DNAJB6	genes/human/DNAJB6/DNAJB6-ai-review.yaml	DNAJB6	O75190	NCBITaxon:9606	Homo sapiens	26	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	This TAS annotation from Reactome (R-HSA-5251959, HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol) correctly identifies DNAJB6 as an activator of HSP70 ATPase activity in the cytosol. The Reactome pathway explicitly mentions DNAJB6 (as DNAJB6) among the HSP40s that dramatically increase HSP70 ATPase activity, citing Izawa et al. 2000 (PMID:10954706). Duplicate of the nucleoplasm-specific annotation above but refers to the cytosolic context (isoform B).
human	DNAJB6	genes/human/DNAJB6/DNAJB6-ai-review.yaml	DNAJB6	O75190	NCBITaxon:9606	Homo sapiens	36	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	This TAS annotation from Reactome (R-HSA-5251955, HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm) places DNAJB6 in the nucleoplasm as the site where it stimulates HSP70 ATPase activity. This is consistent with the nuclear localization of DNAJB6a and the HPA immunofluorescence data showing nucleoplasm localization.
human	DNAJB6	genes/human/DNAJB6/DNAJB6-ai-review.yaml	DNAJB6	O75190	NCBITaxon:9606	Homo sapiens	37	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This TAS annotation from Reactome (R-HSA-5251959, HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol) places DNAJB6 in the cytosol where it stimulates HSP70 ATPase activity. The Reactome entry explicitly names DNAJB6 among the HSP40s with this function. Consistent with the well-established cytosolic localization of DNAJB6b.
human	DNAJC13	genes/human/DNAJC13/DNAJC13-ai-review.yaml	DNAJC13	O75165	NCBITaxon:9606	Homo sapiens	12	R-HSA-6798739	Neutrophil degranulation (azurophil granule)	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from the neutrophil-degranulation pathway placing DNAJC13 at the plasma membrane. This reflects bulk granule/membrane proteome curation, not DNAJC13's core endosomal function.
human	DNAJC13	genes/human/DNAJC13/DNAJC13-ai-review.yaml	DNAJC13	O75165	NCBITaxon:9606	Homo sapiens	13	R-HSA-6798743	Neutrophil degranulation (secretory granule / plasma membrane)	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Second Reactome (neutrophil degranulation) plasma-membrane annotation, redundant with the R-HSA-6798739 entry.
human	DNAJC13	genes/human/DNAJC13/DNAJC13-ai-review.yaml	DNAJC13	O75165	NCBITaxon:9606	Homo sapiens	14	R-HSA-6798743	Neutrophil degranulation (secretory granule / plasma membrane)	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation annotation placing DNAJC13 in the secretory granule membrane. Reflects bulk granule-proteome curation rather than a defined granule function.
human	DNAJC13	genes/human/DNAJC13/DNAJC13-ai-review.yaml	DNAJC13	O75165	NCBITaxon:9606	Homo sapiens	15	R-HSA-6798739	Neutrophil degranulation (azurophil granule)	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation annotation placing DNAJC13 in the azurophil granule membrane. Reflects bulk granule-proteome curation.
human	DNAJC3	genes/human/DNAJC3/DNAJC3-ai-review.yaml	DNAJC3	Q13217	NCBITaxon:9606	Homo sapiens	18	R-HSA-8952289	Reactome annotation (ER lumen localization of DNAJC3)	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome-curated ER-lumen localization, consistent with DNAJC3's ER residence.
human	DNAJC3	genes/human/DNAJC3/DNAJC3-ai-review.yaml	DNAJC3	Q13217	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Neutrophil degranulation (Reactome)	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from neutrophil-degranulation curation. This reflects a secretome/granule context, not DNAJC3's core ER co-chaperone function.
human	DNAJC3	genes/human/DNAJC3/DNAJC3-ai-review.yaml	DNAJC3	Q13217	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798751	Neutrophil degranulation (Reactome)	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from neutrophil azurophil-granule curation; a specialized context distinct from DNAJC3's ER co-chaperone role.
human	DNAJC3	genes/human/DNAJC3/DNAJC3-ai-review.yaml	DNAJC3	Q13217	NCBITaxon:9606	Homo sapiens	32	R-HSA-1791157	Reactome annotation (ER lumen localization of DNAJC3)	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome-curated ER-lumen localization, consistent with DNAJC3's ER residence.
human	DNAJC3	genes/human/DNAJC3/DNAJC3-ai-review.yaml	DNAJC3	Q13217	NCBITaxon:9606	Homo sapiens	33	R-HSA-9835454	PKR-mediated signaling (Reactome)	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-curated cytosolic localization, consistent with the cytosolic pool engaging PKR. Secondary to ER residence.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	23	R-HSA-6798739	Neutrophil degranulation (azurophil granule membrane)	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation pathway annotation placing CSPalpha on the azurophil granule membrane.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799350	Neutrophil degranulation (specific granule membrane)	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation annotation placing CSPalpha on the specific granule membrane.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798739	Neutrophil degranulation (azurophil granule membrane)	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation annotation placing CSPalpha at the plasma membrane (post-fusion).
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799350	Neutrophil degranulation (specific granule membrane)	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome neutrophil-degranulation annotation placing CSPalpha at the plasma membrane.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	31	R-HSA-888589	GABA synthesis, release, reuptake and degradation	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome GABA-vesicle pathway annotation placing CSPalpha at the plasma membrane.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	32	R-HSA-888589	GABA synthesis, release, reuptake and degradation	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation placing CSPalpha on the clathrin-sculpted GABA transport vesicle membrane, a specific synaptic-vesicle subtype membrane.
human	DNAJC5	genes/human/DNAJC5/DNAJC5-ai-review.yaml	DNAJC5	Q9H3Z4	NCBITaxon:9606	Homo sapiens	33	R-HSA-917744	Clathrin-sculpted GABA transport vesicle membrane localization	yes	reactome/R-HSA-917744.md	GABA loaded synaptic vesicle Docking and Priming	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Second Reactome annotation for the clathrin-sculpted GABA transport vesicle membrane.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	24	R-HSA-421836	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization for auxilin (clathrin-mediated endocytosis pathway); auxilin cycles between a soluble cytosolic pool and clathrin coats.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	25	R-HSA-432688	Vesicle biogenesis (cytosol localization)	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization (vesicle biogenesis pathway).
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	26	R-HSA-8868658	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	27	R-HSA-8868659	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	28	R-HSA-8868660	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	29	R-HSA-8869438	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	30	R-HSA-8871193	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC6	genes/human/DNAJC6/DNAJC6-ai-review.yaml	DNAJC6	O75061	NCBITaxon:9606	Homo sapiens	31	R-HSA-8871194	Clathrin-mediated endocytosis (cytosol localization)	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant Reactome cytosol localization.
human	DNAJC7	genes/human/DNAJC7/DNAJC7-ai-review.yaml	DNAJC7	Q99615	NCBITaxon:9606	Homo sapiens	12	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing DNAJC7 in regulation of the HSF1-mediated heat shock response. As an HSP40 co-chaperone it participates in the proteostasis/HSR circuitry, a plausible but non-core downstream process.
human	DNAJC7	genes/human/DNAJC7/DNAJC7-ai-review.yaml	DNAJC7	Q99615	NCBITaxon:9606	Homo sapiens	17	R-HSA-5251955	HSP70/HSP90 chaperone cycle (Reactome)	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	DNAJC7's J domain stimulates ATP hydrolysis by HSP70, the defining molecular function of J-domain co-chaperones. Directly demonstrated biochemically.
human	DNAJC7	genes/human/DNAJC7/DNAJC7-ai-review.yaml	DNAJC7	Q99615	NCBITaxon:9606	Homo sapiens	18	R-HSA-5251959	HSP70/HSP90 chaperone cycle (Reactome)	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0001671	ATPase activator activity	TAS	enables	MF	false		ACCEPT	Duplicate Reactome-sourced annotation of HSP70 ATPase stimulation by the J domain, a core molecular function of DNAJC7.
human	DNAJC7	genes/human/DNAJC7/DNAJC7-ai-review.yaml	DNAJC7	Q99615	NCBITaxon:9606	Homo sapiens	21	R-HSA-5251955	HSP70/HSP90 chaperone cycle (Reactome)	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-curated nucleoplasmic localization, consistent with the documented nuclear pool of DNAJC7.
human	DNAJC7	genes/human/DNAJC7/DNAJC7-ai-review.yaml	DNAJC7	Q99615	NCBITaxon:9606	Homo sapiens	22	R-HSA-5251959	HSP70/HSP90 chaperone cycle (Reactome)	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway-curated cytosolic localization, the primary compartment of DNAJC7 action.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	57	R-HSA-4655431	SUMOyation of DNMT1 with SUMO1	yes	reactome/R-HSA-4655431.md	SUMOyation of DNMT1 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DNMT1 localization to nucleoplasm is accurate as it functions throughout the nuclear compartment. This Reactome annotation focuses on DNMT1 SUMOylation pathway.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	65	R-HSA-212222	PRC2 recruits DNA methyltransferases	yes	reactome/R-HSA-212222.md	PRC2 recruits DNA methyltransferases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway for PRC2 recruitment of DNA methyltransferases. This represents functional nucleoplasm localization in chromatin regulation context.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	66	R-HSA-212269	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3	yes	reactome/R-HSA-212269.md	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway showing DNMT1,3A,3B and PRC2 coordinate cytosine and histone methylation. Functional nucleoplasm localization.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	67	R-HSA-9710490	The GSDME gene promoter is hypermethylated	yes	reactome/R-HSA-9710490.md	The GSDME gene promoter is hypermethylated	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway about GSDME gene promoter hypermethylation. This represents DNMT1 functional localization at target gene promoters.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	68	R-HSA-9851058	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene	yes	reactome/R-HSA-9851058.md	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway showing STAT3 and DNMT1 binding to IL2RG gene. This represents functional nucleoplasm localization for gene-specific regulation.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	69	R-HSA-9851071	STAT3, DNMT1 and HDAC1 bind PTPN6 gene	yes	reactome/R-HSA-9851071.md	STAT3, DNMT1 and HDAC1 bind PTPN6 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway showing STAT3, DNMT1 and HDAC1 binding to PTPN6 gene. Functional nucleoplasm localization for multi-protein transcriptional complex.
human	DNMT1	genes/human/DNMT1/DNMT1-ai-review.yaml	DNMT1	P26358	NCBITaxon:9606	Homo sapiens	70	R-HSA-9851145	Translation of DNMT1 mRNA is repressed by miR-21	yes	reactome/R-HSA-9851145.md	Translation of DNMT1 mRNA is repressed by miR-21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization annotation from Reactome pathway about miR-21 repression of DNMT1 mRNA translation. This represents DNMT1 subcellular localization for post-transcriptional regulation.
human	DNMT3A	genes/human/DNMT3A/DNMT3A-ai-review.yaml	DNMT3A	Q9Y6K1	NCBITaxon:9606	Homo sapiens	47	R-HSA-212222	PRC2 recruits DNA methyltransferases	yes	reactome/R-HSA-212222.md	PRC2 recruits DNA methyltransferases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DNMT3A acts in the nucleus and nucleoplasm.
human	DNMT3A	genes/human/DNMT3A/DNMT3A-ai-review.yaml	DNMT3A	Q9Y6K1	NCBITaxon:9606	Homo sapiens	48	R-HSA-212269	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3	yes	reactome/R-HSA-212269.md	DNMT1,3A,3B:PRC2 methylates cytosine and histone H3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DNMT3A acts in the nucleus and nucleoplasm.
human	DNMT3A	genes/human/DNMT3A/DNMT3A-ai-review.yaml	DNMT3A	Q9Y6K1	NCBITaxon:9606	Homo sapiens	49	R-HSA-5212679	DNMT3A binds Me2sR4-HIST1H4	yes	reactome/R-HSA-5212679.md	DNMT3A binds Me2sR4-HIST1H4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DNMT3A acts in the nucleus and nucleoplasm.
human	DNMT3A	genes/human/DNMT3A/DNMT3A-ai-review.yaml	DNMT3A	Q9Y6K1	NCBITaxon:9606	Homo sapiens	50	R-HSA-9710490	The GSDME gene promoter is hypermethylated	yes	reactome/R-HSA-9710490.md	The GSDME gene promoter is hypermethylated	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	DNMT3A acts in the nucleus and nucleoplasm.
human	DOLK	genes/human/DOLK/DOLK-ai-review.yaml	DOLK	Q9UPQ8	NCBITaxon:9606	Homo sapiens	11	R-HSA-446199	Synthesis of dolichyl-phosphate	yes	reactome/R-HSA-446199.md	Synthesis of dolichyl-phosphate	Homo sapiens	GO:0043048	dolichyl monophosphate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in dolichyl phosphate synthesis, matching the enzyme's pathway role.
human	DOLK	genes/human/DOLK/DOLK-ai-review.yaml	DOLK	Q9UPQ8	NCBITaxon:9606	Homo sapiens	12	R-HSA-446195	DOLK phosphorylates DCHOL to DOLP	yes	reactome/R-HSA-446195.md	DOLK phosphorylates DCHOL to DOLP	Homo sapiens	GO:0004168	dolichol kinase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted dolichol kinase activity (DOLK phosphorylates dolichol to Dol-P), matching the core molecular function.
human	DOLK	genes/human/DOLK/DOLK-ai-review.yaml	DOLK	Q9UPQ8	NCBITaxon:9606	Homo sapiens	13	R-HSA-4755600	Defective DOLK does not phosphorylate DCHOL	yes	reactome/R-HSA-4755600.md	Defective DOLK does not phosphorylate DCHOL	Homo sapiens	GO:0004168	dolichol kinase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted dolichol kinase activity (disease-annotated reaction), matching the core molecular function.
human	DOLK	genes/human/DOLK/DOLK-ai-review.yaml	DOLK	Q9UPQ8	NCBITaxon:9606	Homo sapiens	19	R-HSA-4755600	Defective DOLK does not phosphorylate DCHOL	yes	reactome/R-HSA-4755600.md	Defective DOLK does not phosphorylate DCHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization, consistent with experimental data.
human	DOLK	genes/human/DOLK/DOLK-ai-review.yaml	DOLK	Q9UPQ8	NCBITaxon:9606	Homo sapiens	20	R-HSA-446195	DOLK phosphorylates DCHOL to DOLP	yes	reactome/R-HSA-446195.md	DOLK phosphorylates DCHOL to DOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER membrane localization, consistent with experimental data.
human	DOLPP1	genes/human/DOLPP1/DOLPP1-ai-review.yaml	DOLPP1	Q86YN1	NCBITaxon:9606	Homo sapiens	7	R-HSA-446199	Synthesis of dolichyl-phosphate	yes	reactome/R-HSA-446199.md	Synthesis of dolichyl-phosphate	Homo sapiens	GO:0043048	dolichyl monophosphate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Appropriate. The direct product of DOLPP1 is dolichyl phosphate (dolichyl monophosphate), formed by dephosphorylation of dolichyl-PP; this salvage reaction is one route to dolichyl-P. Reactome curates DOLPP1 within the ""Synthesis of dolichyl-phosphate"" pathway, so this process annotation captures the enzyme's product-forming role."
human	DOLPP1	genes/human/DOLPP1/DOLPP1-ai-review.yaml	DOLPP1	Q86YN1	NCBITaxon:9606	Homo sapiens	8	R-HSA-446200	DOLPP1 dephosphorylates DOLDP to DOLP	yes	reactome/R-HSA-446200.md	DOLPP1 dephosphorylates DOLDP to DOLP	Homo sapiens	GO:0047874	dolichyldiphosphatase activity	TAS	enables	MF	false		ACCEPT	"Correct core molecular function, curated by Reactome (reaction ""DOLPP1 dephosphorylates DOLDP to DOLP""). Consistent with the UniProt catalytic activity and EC 3.6.1.43."
human	DOLPP1	genes/human/DOLPP1/DOLPP1-ai-review.yaml	DOLPP1	Q86YN1	NCBITaxon:9606	Homo sapiens	10	R-HSA-446200	DOLPP1 dephosphorylates DOLDP to DOLP	yes	reactome/R-HSA-446200.md	DOLPP1 dephosphorylates DOLDP to DOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane localization, curated by Reactome. Consistent with the UniProt subcellular location and multi-pass membrane topology.
human	DPAGT1	genes/human/DPAGT1/DPAGT1-ai-review.yaml	DPAGT1	Q9H3H5	NCBITaxon:9606	Homo sapiens	9	R-HSA-446193	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	yes	reactome/R-HSA-446193.md	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion linking DPAGT1 to biosynthesis of the dolichol lipid-linked oligosaccharide (LLO) precursor. Consistent with DPAGT1's role initiating the 14-sugar N-glycan precursor pathway.
human	DPAGT1	genes/human/DPAGT1/DPAGT1-ai-review.yaml	DPAGT1	Q9H3H5	NCBITaxon:9606	Homo sapiens	10	R-HSA-446191	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate	yes	reactome/R-HSA-446191.md	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate	Homo sapiens	GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the GlcNAc-1-P transferase reaction (addition of N-acetylglucosamine to dolichyl phosphate). Matches the defining catalytic activity of DPAGT1.
human	DPAGT1	genes/human/DPAGT1/DPAGT1-ai-review.yaml	DPAGT1	Q9H3H5	NCBITaxon:9606	Homo sapiens	11	R-HSA-4549334	Defective DPAGT1 does not transfer GlcNAc to DOLP	yes	reactome/R-HSA-4549334.md	Defective DPAGT1 does not transfer GlcNAc to DOLP	Homo sapiens	GO:0003975	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (disease-variant reaction 'Defective DPAGT1 does not transfer GlcNAc to DOLP') again attributing the GlcNAc-1-P transferase activity to DPAGT1. Duplicate of the core catalytic function.
human	DPAGT1	genes/human/DPAGT1/DPAGT1-ai-review.yaml	DPAGT1	Q9H3H5	NCBITaxon:9606	Homo sapiens	19	R-HSA-4549334	Defective DPAGT1 does not transfer GlcNAc to DOLP	yes	reactome/R-HSA-4549334.md	Defective DPAGT1 does not transfer GlcNAc to DOLP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DPAGT1 to the ER membrane (disease-variant reaction context). Consistent with the experimentally supported ER membrane residence.
human	DPAGT1	genes/human/DPAGT1/DPAGT1-ai-review.yaml	DPAGT1	Q9H3H5	NCBITaxon:9606	Homo sapiens	20	R-HSA-446191	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate	yes	reactome/R-HSA-446191.md	Addition of N-acetyl-D-glucosamine to Dolichyl phosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DPAGT1 to the ER membrane in the LLO-synthesis reaction. The dolichyl phosphate anchor ties the reaction to the ER membrane.
human	DPEP1	genes/human/DPEP1/DPEP1-ai-review.yaml	DPEP1	P16444	NCBITaxon:9606	Homo sapiens	37	R-HSA-266012	LTD4 is converted to LTE4 by DPEP1/2	yes	reactome/R-HSA-266012.md	LTD4 is converted to LTE4 by DPEP1/2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places DPEP1 at the plasma membrane in the reaction converting LTD4 to LTE4. This is consistent with its GPI-anchored apical-membrane localization.
human	DPEP1	genes/human/DPEP1/DPEP1-ai-review.yaml	DPEP1	P16444	NCBITaxon:9606	Homo sapiens	38	R-HSA-5433067	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG	yes	reactome/R-HSA-5433067.md	DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places DPEP1 at the plasma membrane in a reaction hydrolyzing glycine from aflatoxin-glutathione conjugate detoxification intermediates, consistent with its apical-membrane localization.
human	DPM1	genes/human/DPM1/DPM1-ai-review.yaml	DPM1	O60762	NCBITaxon:9606	Homo sapiens	14	R-HSA-162699	Synthesis of dolichyl-phosphate mannose	yes	reactome/R-HSA-162699.md	Synthesis of dolichyl-phosphate mannose	Homo sapiens	GO:0006488	dolichol-linked oligosaccharide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation for synthesis of dolichyl-phosphate mannose within LLO biosynthesis. Dol-P-Man produced by DPM1 donates the lumenal mannoses of the dolichol-linked oligosaccharide precursor.
human	DPM1	genes/human/DPM1/DPM1-ai-review.yaml	DPM1	O60762	NCBITaxon:9606	Homo sapiens	26	R-HSA-4717406	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4717406.md	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation locating DPM1 at the ER membrane (in the reaction representing defective DPM1 that fails to form Dol-P-Man in DPM1-CDG).
human	DPM1	genes/human/DPM1/DPM1-ai-review.yaml	DPM1	O60762	NCBITaxon:9606	Homo sapiens	29	R-HSA-162721	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	yes	reactome/R-HSA-162721.md	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation locating the DPM synthase reaction at the ER membrane.
human	DPM1	genes/human/DPM1/DPM1-ai-review.yaml	DPM1	O60762	NCBITaxon:9606	Homo sapiens	30	R-HSA-4719354	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719354.md	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (defective DPM3 reaction) placing the DPM synthase at the ER membrane.
human	DPM1	genes/human/DPM1/DPM1-ai-review.yaml	DPM1	O60762	NCBITaxon:9606	Homo sapiens	31	R-HSA-4719375	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719375.md	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (defective DPM2 reaction) placing the DPM synthase at the ER membrane.
human	DPM2	genes/human/DPM2/DPM2-ai-review.yaml	DPM2	O94777	NCBITaxon:9606	Homo sapiens	20	R-HSA-4719375	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719375.md	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) ER membrane localization from the ""Defective DPM2 does not transfer mannose to DOLP to form DOLPman"" reaction. Correct localization."
human	DPM2	genes/human/DPM2/DPM2-ai-review.yaml	DPM2	O94777	NCBITaxon:9606	Homo sapiens	21	R-HSA-162721	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	yes	reactome/R-HSA-162721.md	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from the dolichyl phosphate + GDP-mannose -> Dol-P-Man reaction. Correct localization.
human	DPM2	genes/human/DPM2/DPM2-ai-review.yaml	DPM2	O94777	NCBITaxon:9606	Homo sapiens	22	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) ER membrane localization from the GPI-GnT reaction (PI + UDP-GlcNAc -> GlcNAc-PI + UDP). Correct localization.
human	DPM2	genes/human/DPM2/DPM2-ai-review.yaml	DPM2	O94777	NCBITaxon:9606	Homo sapiens	23	R-HSA-4717406	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4717406.md	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) ER membrane localization from the ""Defective DPM1 does not transfer mannose to DOLP to form DOLPman"" reaction. Correct localization."
human	DPM2	genes/human/DPM2/DPM2-ai-review.yaml	DPM2	O94777	NCBITaxon:9606	Homo sapiens	24	R-HSA-4719354	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719354.md	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS (Reactome) ER membrane localization from the ""Defective DPM3 does not transfer mannose to DOLP to form DOLPman"" reaction. Correct localization."
human	DPM3	genes/human/DPM3/DPM3-ai-review.yaml	DPM3	Q9P2X0	NCBITaxon:9606	Homo sapiens	16	R-HSA-4719354	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719354.md	Defective DPM3 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of DPM3 to the ER membrane, from the pathway describing defective DPM3 failing to form Dol-P-Man. Consistent with all other ER-membrane evidence.
human	DPM3	genes/human/DPM3/DPM3-ai-review.yaml	DPM3	Q9P2X0	NCBITaxon:9606	Homo sapiens	18	R-HSA-162721	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	yes	reactome/R-HSA-162721.md	dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of DPM3 to the ER membrane, from the pathway for the Dol-P-Man synthesis reaction (dolichyl phosphate + GDP-mannose -> dolichyl phosphate D-mannose) catalysed by the ER-membrane DPM synthase.
human	DPM3	genes/human/DPM3/DPM3-ai-review.yaml	DPM3	Q9P2X0	NCBITaxon:9606	Homo sapiens	19	R-HSA-4717406	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4717406.md	Defective DPM1 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of DPM3 to the ER membrane, from the pathway describing defective DPM1 failing to form Dol-P-Man; the DPM complex (including DPM3) is annotated at the ER membrane.
human	DPM3	genes/human/DPM3/DPM3-ai-review.yaml	DPM3	Q9P2X0	NCBITaxon:9606	Homo sapiens	20	R-HSA-4719375	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	yes	reactome/R-HSA-4719375.md	Defective DPM2 does not transfer mannose to DOLP to form DOLPman	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization of DPM3 to the ER membrane, from the pathway describing defective DPM2 failing to form Dol-P-Man; the DPM complex (including DPM3) is annotated at the ER membrane.
human	DPYD	genes/human/DPYD/DPYD-ai-review.yaml	DPYD	Q12882	NCBITaxon:9606	Homo sapiens	22	R-HSA-73585	reduction of uracil to form dihydrouracil	yes	reactome/R-HSA-73585.md	reduction of uracil to form dihydrouracil	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of the uracil-reducing reaction to the cytosol. Concordant with all other localization evidence.
human	DPYD	genes/human/DPYD/DPYD-ai-review.yaml	DPYD	Q12882	NCBITaxon:9606	Homo sapiens	23	R-HSA-73616	reduction of thymine to form 5,6-Dihydrothymine	yes	reactome/R-HSA-73616.md	reduction of thymine to form 5,6-Dihydrothymine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of the thymine-reducing reaction to the cytosol. Concordant with all other localization evidence.
human	DPYS	genes/human/DPYS/DPYS-ai-review.yaml	DPYS	Q14117	NCBITaxon:9606	Homo sapiens	14	R-HSA-73589	conversion of 5,6-dihydrouracil to 3-ureidopropionate	yes	reactome/R-HSA-73589.md	conversion of 5,6-dihydrouracil to 3-ureidopropionate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization for the conversion of 5,6-dihydrouracil to 3-ureidopropionate. Matches the enzyme's soluble cytosolic nature.
human	DPYS	genes/human/DPYS/DPYS-ai-review.yaml	DPYS	Q14117	NCBITaxon:9606	Homo sapiens	15	R-HSA-73618	conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate	yes	reactome/R-HSA-73618.md	conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization for the conversion of 5,6-dihydrothymine to 3-ureidoisobutyrate. Matches the enzyme's soluble cytosolic nature.
human	DPYSL2	genes/human/DPYSL2/DPYSL2-ai-review.yaml	DPYSL2	Q16555	NCBITaxon:9606	Homo sapiens	36	R-HSA-399951	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL2 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL2	genes/human/DPYSL2/DPYSL2-ai-review.yaml	DPYSL2	Q16555	NCBITaxon:9606	Homo sapiens	37	R-HSA-399944	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL2 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL2	genes/human/DPYSL2/DPYSL2-ai-review.yaml	DPYSL2	Q16555	NCBITaxon:9606	Homo sapiens	38	R-HSA-399947	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399947.md	Tyrosine phosphorylation of CRMPs by Fes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL2 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL2	genes/human/DPYSL2/DPYSL2-ai-review.yaml	DPYSL2	Q16555	NCBITaxon:9606	Homo sapiens	39	R-HSA-443783	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-443783.md	Interaction of NUMB with L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL2 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL3	genes/human/DPYSL3/DPYSL3-ai-review.yaml	DPYSL3	Q14195	NCBITaxon:9606	Homo sapiens	37	R-HSA-399951	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL3 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL3	genes/human/DPYSL3/DPYSL3-ai-review.yaml	DPYSL3	Q14195	NCBITaxon:9606	Homo sapiens	38	R-HSA-399944	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL3 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL3	genes/human/DPYSL3/DPYSL3-ai-review.yaml	DPYSL3	Q14195	NCBITaxon:9606	Homo sapiens	39	R-HSA-399947	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399947.md	Tyrosine phosphorylation of CRMPs by Fes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL3 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL4	genes/human/DPYSL4/DPYSL4-ai-review.yaml	DPYSL4	O14531	NCBITaxon:9606	Homo sapiens	14	R-HSA-399944	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL4 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL4	genes/human/DPYSL4/DPYSL4-ai-review.yaml	DPYSL4	O14531	NCBITaxon:9606	Homo sapiens	15	R-HSA-399947	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399947.md	Tyrosine phosphorylation of CRMPs by Fes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL4 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL4	genes/human/DPYSL4/DPYSL4-ai-review.yaml	DPYSL4	O14531	NCBITaxon:9606	Homo sapiens	16	R-HSA-399951	Reactome pathway (CRMP/semaphorin signalling)	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for DPYSL4 (cytoplasmic/cytoskeletal CRMP).
human	DPYSL5	genes/human/DPYSL5/DPYSL5-ai-review.yaml	DPYSL5	Q9BPU6	NCBITaxon:9606	Homo sapiens	21	R-HSA-399944	Other semaphorin interactions (CRMP signalling).	yes	reactome/R-HSA-399944.md	Phosphorylation of CRMPs by Cdk5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome TAS, semaphorin/CRMP signalling reaction).
human	DPYSL5	genes/human/DPYSL5/DPYSL5-ai-review.yaml	DPYSL5	Q9BPU6	NCBITaxon:9606	Homo sapiens	22	R-HSA-399947	CRMP phosphorylation / semaphorin signalling reaction.	yes	reactome/R-HSA-399947.md	Tyrosine phosphorylation of CRMPs by Fes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome TAS).
human	DPYSL5	genes/human/DPYSL5/DPYSL5-ai-review.yaml	DPYSL5	Q9BPU6	NCBITaxon:9606	Homo sapiens	23	R-HSA-399951	CRMP signalling reaction.	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome TAS).
human	DRG2	genes/human/DRG2/DRG2-ai-review.yaml	DRG2	P55039	NCBITaxon:9606	Homo sapiens	14	R-HSA-9629578	Reactome cytosolic localization annotation for DRG2.	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, consistent with the IDA cytosol annotation.
human	DSCAM	genes/human/DSCAM/DSCAM-ai-review.yaml	DSCAM	O60469	NCBITaxon:9606	Homo sapiens	46	R-HSA-376122	DSCAM/DSCAML1 homodimerization	yes	reactome/R-HSA-376122.md	DSCAM/DSCAML1 homodimerization	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for DSCAM/DSCAML1 homodimerization, which occurs at the plasma membrane.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	34	R-HSA-5652005	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	yes	reactome/R-HSA-5652005.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization within the PCNA monoubiquitination (TLS) reaction. Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	35	R-HSA-5652009	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	yes	reactome/R-HSA-5652009.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (PCNA monoubiquitination reaction). Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	36	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (CRL4 neddylation reaction). Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	37	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (NEDD8 binding to CRL4). Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	38	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (CAND1 binding to nuclear CRL4). Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	39	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (COMMD displacement of CAND1). Core compartment.
human	DTL	genes/human/DTL/DTL-ai-review.yaml	DTL	Q9NZJ0	NCBITaxon:9606	Homo sapiens	40	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of DTL nucleoplasm localization (COP9 signalosome deneddylates nuclear CRL4). Core compartment.
human	DTYMK	genes/human/DTYMK/DTYMK-ai-review.yaml	DTYMK	P23919	NCBITaxon:9606	Homo sapiens	20	R-HSA-73635	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]	yes	reactome/R-HSA-73635.md	dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing DTYMK to the cytosol, consistent with the enzyme being a small soluble cytosolic kinase. This is the core, functionally relevant compartment.
human	DTYMK	genes/human/DTYMK/DTYMK-ai-review.yaml	DTYMK	P23919	NCBITaxon:9606	Homo sapiens	21	R-HSA-75126	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]	yes	reactome/R-HSA-75126.md	dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement (reverse reaction module) localizing DTYMK to the cytosol; duplicate of the cytosol call and equally correct.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	13	R-HSA-209815	Tyrosine is monoiodinated	yes	reactome/R-HSA-209815.md	Tyrosine is monoiodinated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	14	R-HSA-209840	Two DITs combine to form thyroxine	yes	reactome/R-HSA-209840.md	Two DITs combine to form thyroxine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	15	R-HSA-209925	DIT and MIT combine to form triiodothyronine	yes	reactome/R-HSA-209925.md	DIT and MIT combine to form triiodothyronine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	16	R-HSA-209973	Tyrosine is diiodinated	yes	reactome/R-HSA-209973.md	Tyrosine is diiodinated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	17	R-HSA-350901	Iodide is organified	yes	reactome/R-HSA-350901.md	Iodide is organified	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	18	R-HSA-5693681	DUOX1 reduces O2 to H2O2	yes	reactome/R-HSA-5693681.md	DUOX1 reduces O2 to H2O2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	29	R-HSA-5693681	DUOX1 reduces O2 to H2O2	yes	reactome/R-HSA-5693681.md	DUOX1 reduces O2 to H2O2	Homo sapiens	GO:0016174	NAD(P)H oxidase H2O2-forming activity	TAS	enables	MF	false		ACCEPT	NAD(P)H oxidase H2O2-forming activity: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUOX1	genes/human/DUOX1/DUOX1-ai-review.yaml	DUOX1	Q9NRD9	NCBITaxon:9606	Homo sapiens	58	R-HSA-5693681	DUOX1 reduces O2 to H2O2	yes	reactome/R-HSA-5693681.md	DUOX1 reduces O2 to H2O2	Homo sapiens	GO:0050665	hydrogen peroxide biosynthetic process	TAS	involved_in	BP	false		ACCEPT	hydrogen peroxide biosynthetic process: Human DUOX1–DUOXA1 structures and functional experiments establish a membrane oxidase complex using heme, FAD and NADPH to generate extracellular H2O2, regulated by calcium-binding EF-hand elements. These are direct components of the oxidase mechanism.
human	DUT	genes/human/DUT/DUT-ai-review.yaml	DUT	P33316	NCBITaxon:9606	Homo sapiens	36	R-HSA-73666	hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate	yes	reactome/R-HSA-73666.md	hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the major (nuclear) dUTPase isoform in the nucleoplasm, where it catalyzes hydrolysis of dUTP to dUMP and pyrophosphate.
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	61	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	Extracellular/azurophil granule lumen location from the Reactome neutrophil degranulation proteomic event.
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	65	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	66	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	67	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	68	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	69	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	70	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	71	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	72	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	73	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	74	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	75	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	76	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	77	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	78	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	79	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	80	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	81	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	82	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	83	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	84	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	85	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	86	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	87	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	88	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	89	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	90	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	91	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	92	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	93	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	94	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	95	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	96	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	97	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	98	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	99	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	100	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	101	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	102	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	103	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	104	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	105	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	106	R-HSA-9614343	Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs	yes	reactome/R-HSA-9614343.md	Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	107	R-HSA-9614367	HCMV Nuclear Pore Docking	yes	reactome/R-HSA-9614367.md	HCMV Nuclear Pore Docking	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	108	R-HSA-9646348	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	yes	reactome/R-HSA-9646348.md	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	109	R-HSA-9646679	PolyUb-Misfolded proteins bind vimentin to form aggresome	yes	reactome/R-HSA-9646679.md	PolyUb-Misfolded proteins bind vimentin to form aggresome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	110	R-HSA-9646685	Aggresome dissociates from dynein and microtubule	yes	reactome/R-HSA-9646685.md	Aggresome dissociates from dynein and microtubule	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	111	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	112	R-NUL-9646387	Dynein motors transport misfolded proteins	yes	reactome/R-NUL-9646387.md	Dynein motors transport misfolded proteins	Cercopithecus aethiops	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	DYNC1H1	genes/human/DYNC1H1/DYNC1H1-ai-review.yaml	DYNC1H1	Q14204	NCBITaxon:9606	Homo sapiens	140	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		REMOVE	Extracellular/azurophil granule lumen location from the Reactome neutrophil degranulation proteomic event.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	89	R-HSA-187937	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3	yes	reactome/R-HSA-187937.md	Association of Cyclin A:phospho-Cdk2(Thr 160) with E2F1/E2F3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-187937 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	90	R-HSA-187959	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)	yes	reactome/R-HSA-187959.md	Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-187959 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	91	R-HSA-3209096	E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter	yes	reactome/R-HSA-3209096.md	E2F1, E2F2, or E2F3 and SP1 bind p14ARF promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-3209096 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	92	R-HSA-3240765	E2F1/2/3:DP1/2 binds EED gene promoter	yes	reactome/R-HSA-3240765.md	E2F1/2/3:DP1/2 binds EED gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-3240765 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	93	R-HSA-3240766	E2F1/2/3:DP1/2 binds SUZ12 gene promoter	yes	reactome/R-HSA-3240766.md	E2F1/2/3:DP1/2 binds SUZ12 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-3240766 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	94	R-HSA-3240777	E2F1/2/3:DP1/2 binds EZH2 gene promoter	yes	reactome/R-HSA-3240777.md	E2F1/2/3:DP1/2 binds EZH2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-3240777 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	95	R-HSA-4331324	E2F1 binds BBC3 (PUMA) promoter	yes	reactome/R-HSA-4331324.md	E2F1 binds BBC3 (PUMA) promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-4331324 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	96	R-HSA-4331327	E2F1 binds PMAIP1 (NOXA) promoter	yes	reactome/R-HSA-4331327.md	E2F1 binds PMAIP1 (NOXA) promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-4331327 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	97	R-HSA-4395231	E2F1/3:DP1/2 binds NOTCH1 promoter	yes	reactome/R-HSA-4395231.md	E2F1/3:DP1/2 binds NOTCH1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-4395231 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	98	R-HSA-6798353	E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression	yes	reactome/R-HSA-6798353.md	E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-6798353 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	99	R-HSA-8953556	E2F1 gene transcription is inhibited by E2F6	yes	reactome/R-HSA-8953556.md	E2F1 gene transcription is inhibited by E2F6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8953556 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	100	R-HSA-8961620	E2F1 binds the CDC6 gene promoter	yes	reactome/R-HSA-8961620.md	E2F1 binds the CDC6 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961620 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	101	R-HSA-8961636	E2F1 binds the POLA1 gene promoter	yes	reactome/R-HSA-8961636.md	E2F1 binds the POLA1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961636 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	102	R-HSA-8961651	E2F1 binds the PCNA gene promoter	yes	reactome/R-HSA-8961651.md	E2F1 binds the PCNA gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961651 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	103	R-HSA-8961671	E2F1 binds the ORC1 gene promoter	yes	reactome/R-HSA-8961671.md	E2F1 binds the ORC1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961671 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	104	R-HSA-8961688	E2F1 binds the FBXO5 gene promoter	yes	reactome/R-HSA-8961688.md	E2F1 binds the FBXO5 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961688 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	105	R-HSA-8961840	E2F1 binds the CCNE1 gene promoter	yes	reactome/R-HSA-8961840.md	E2F1 binds the CCNE1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961840 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	106	R-HSA-8961863	E2F1 binds the DHFR gene promoter	yes	reactome/R-HSA-8961863.md	E2F1 binds the DHFR gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961863 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	107	R-HSA-8961888	E2F1 binds the CCNA1 gene promoter	yes	reactome/R-HSA-8961888.md	E2F1 binds the CCNA1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961888 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	108	R-HSA-8961907	E2F1 binds the CDC45 gene promoter	yes	reactome/R-HSA-8961907.md	E2F1 binds the CDC45 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961907 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	109	R-HSA-8961920	E2F1 binds the CDK1 gene promoter	yes	reactome/R-HSA-8961920.md	E2F1 binds the CDK1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961920 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	110	R-HSA-8961946	E2F1 binds the CDT1 gene promoter	yes	reactome/R-HSA-8961946.md	E2F1 binds the CDT1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961946 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	111	R-HSA-8961961	E2F1 binds the CDC25A gene promoter	yes	reactome/R-HSA-8961961.md	E2F1 binds the CDC25A gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-8961961 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	112	R-HSA-9007514	E2F1 binds APAF1 gene promoter	yes	reactome/R-HSA-9007514.md	E2F1 binds APAF1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-9007514 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	113	R-HSA-9007561	E2F1 binds RAD51 gene promoter	yes	reactome/R-HSA-9007561.md	E2F1 binds RAD51 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-9007561 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	114	R-HSA-9018017	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-9018017.md	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-9018017 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	115	R-HSA-9618586	E2F1 binds the promoter of the MYC gene	yes	reactome/R-HSA-9618586.md	E2F1 binds the promoter of the MYC gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-9618586 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	116	R-HSA-9659782	Defective RB1 does not bind E2F1,(E2F2,E2F3)	yes	reactome/R-HSA-9659782.md	Defective RB1 does not bind E2F1,(E2F2,E2F3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-HSA-9659782 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	E2F1	genes/human/E2F1/E2F1-ai-review.yaml	E2F1	Q01094	NCBITaxon:9606	Homo sapiens	117	R-NUL-8963657	E2F1 binds the Tk1 gene promoter	yes	reactome/R-NUL-8963657.md	E2F1 binds the Tk1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS nucleoplasm annotation from Reactome event R-NUL-8963657 (E2F1-containing transcription events in the cell-cycle/G1-S, DNA-damage and apoptosis pathways). E2F1 is a nuclear, chromatin-associated transcription factor.
human	EBP	genes/human/EBP/EBP-ai-review.yaml	EBP	Q15125	NCBITaxon:9606	Homo sapiens	17	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing EBP in the Bloch (via desmosterol) cholesterol biosynthesis pathway.
human	EBP	genes/human/EBP/EBP-ai-review.yaml	EBP	Q15125	NCBITaxon:9606	Homo sapiens	18	R-HSA-9969901	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	yes	reactome/R-HSA-9969901.md	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing EBP in the modified Kandutsch-Russell cholesterol biosynthesis pathway (zymostenol to lathosterol).
human	EBP	genes/human/EBP/EBP-ai-review.yaml	EBP	Q15125	NCBITaxon:9606	Homo sapiens	39	R-HSA-195690	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol	yes	reactome/R-HSA-195690.md	Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation locating the EBP-catalysed zymosterol isomerization at the ER membrane.
human	EBP	genes/human/EBP/EBP-ai-review.yaml	EBP	Q15125	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807052	EBP isomerizes ZYMSTNL to LTHSOL	yes	reactome/R-HSA-6807052.md	EBP isomerizes ZYMSTNL to LTHSOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation locating the EBP-catalysed zymostenol-to-lathosterol isomerization at the ER membrane.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	18	R-HSA-77310	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	yes	reactome/R-HSA-77310.md	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	Homo sapiens	GO:0006635	fatty acid beta-oxidation	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation placing ECHS1 in the beta-oxidation of lauroyl-CoA to decanoyl-CoA. Correct pathway membership; one of several chain-length-specific Reactome steps redundant with the core BP annotation.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	19	R-HSA-77346	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	yes	reactome/R-HSA-77346.md	Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	Homo sapiens	GO:0006635	fatty acid beta-oxidation	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation for beta-oxidation of decanoyl-CoA to octanoyl-CoA.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	20	R-HSA-77348	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	yes	reactome/R-HSA-77348.md	Beta oxidation of octanoyl-CoA to hexanoyl-CoA	Homo sapiens	GO:0006635	fatty acid beta-oxidation	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation for beta-oxidation of octanoyl-CoA to hexanoyl-CoA.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	21	R-HSA-77350	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	yes	reactome/R-HSA-77350.md	Beta oxidation of hexanoyl-CoA to butanoyl-CoA	Homo sapiens	GO:0006635	fatty acid beta-oxidation	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation for beta-oxidation of hexanoyl-CoA to butanoyl-CoA.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	22	R-HSA-77352	Beta oxidation of butanoyl-CoA to acetyl-CoA	yes	reactome/R-HSA-77352.md	Beta oxidation of butanoyl-CoA to acetyl-CoA	Homo sapiens	GO:0006635	fatty acid beta-oxidation	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation for beta-oxidation of butanoyl-CoA to acetyl-CoA (the shortest-chain step, with crotonyl-CoA as the enoyl-CoA substrate).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	23	R-HSA-70895	Branched-chain amino acid catabolism	yes	reactome/R-HSA-70895.md	Branched-chain amino acid catabolism	Homo sapiens	GO:0009083	branched-chain amino acid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of ECHS1 in branched-chain amino acid catabolism, consistent with its hydration of valine/leucine/isoleucine pathway intermediates.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	25	R-HSA-77256	2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA	yes	reactome/R-HSA-77256.md	2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of enoyl-CoA hydratase activity for a specific beta-oxidation reaction (2-trans-dodecenoyl-CoA hydration).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	26	R-HSA-77314	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA	yes	reactome/R-HSA-77314.md	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) enoyl-CoA hydratase activity for crotonoyl-CoA hydration.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	27	R-HSA-77325	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA	yes	reactome/R-HSA-77325.md	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) enoyl-CoA hydratase activity for trans-hex-2-enoyl-CoA hydration.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	28	R-HSA-77333	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA	yes	reactome/R-HSA-77333.md	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) enoyl-CoA hydratase activity for trans-oct-2-enoyl-CoA hydration.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	29	R-HSA-77344	trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA	yes	reactome/R-HSA-77344.md	trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) enoyl-CoA hydratase activity for trans-dec-2-enoyl-CoA hydration.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	30	R-HSA-9916717	ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA	yes	reactome/R-HSA-9916717.md	ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA	Homo sapiens	GO:0004300	enoyl-CoA hydratase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) enoyl-CoA hydratase activity within the ECHS1-deficiency disease pathway (synthesis of beta-hydroxyisobutyryl-CoA from methacrylyl-CoA in valine catabolism).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	36	R-HSA-9916717	ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA	yes	reactome/R-HSA-9916717.md	ECHS1 mutants don't synthesize beta-hydroxyisobutyryl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization within the ECHS1-deficiency pathway.
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	40	R-HSA-70870	ECHS1 hydrates methacrylyl-CoA	yes	reactome/R-HSA-70870.md	ECHS1 hydrates methacrylyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (methacrylyl-CoA hydration reaction).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	41	R-HSA-77256	2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA	yes	reactome/R-HSA-77256.md	2-trans-Dodecenoyl-CoA+H2O =>( S)-3-Hydroxydodecanoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (a beta-oxidation hydration reaction).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	42	R-HSA-77314	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA	yes	reactome/R-HSA-77314.md	Crotonoyl-CoA+H2O => (S)-3-Hydroxybutanoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (crotonoyl-CoA hydration reaction).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	43	R-HSA-77325	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA	yes	reactome/R-HSA-77325.md	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (hex-2-enoyl-CoA hydration reaction).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	44	R-HSA-77333	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA	yes	reactome/R-HSA-77333.md	trans-Oct-2-enoyl-CoA+H2O => (S)-Hydroxyoctanoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (oct-2-enoyl-CoA hydration reaction).
human	ECHS1	genes/human/ECHS1/ECHS1-ai-review.yaml	ECHS1	P30084	NCBITaxon:9606	Homo sapiens	45	R-HSA-77344	trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA	yes	reactome/R-HSA-77344.md	trans-Dec-2-enoyl-CoA+H2O => (S)-Hydroxydecanoyl-CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization (dec-2-enoyl-CoA hydration reaction).
human	EDEM1	genes/human/EDEM1/EDEM1-ai-review.yaml	EDEM1	Q92611	NCBITaxon:9606	Homo sapiens	9	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM1 (with EDEM3) hydrolysing Man8 to Man5 glycans. EDEM1 has genuine but low alpha-1,2-mannosidase activity contributing to the second trimming step.
human	EDEM1	genes/human/EDEM1/EDEM1-ai-review.yaml	EDEM1	Q92611	NCBITaxon:9606	Homo sapiens	15	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	TAS	involved_in	BP	false		ACCEPT	Reactome curation of EDEM1 mannose trimming within the glycoprotein ERAD pathway; an accurate, specific refinement of EDEM1's trimming contribution to ERAD.
human	EDEM1	genes/human/EDEM1/EDEM1-ai-review.yaml	EDEM1	Q92611	NCBITaxon:9606	Homo sapiens	22	R-HSA-1791155	Expression of EDEM	yes	reactome/R-HSA-1791155.md	Expression of EDEM	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM1 ERQC localization (EDEM expression context); consistent with direct IDA evidence.
human	EDEM1	genes/human/EDEM1/EDEM1-ai-review.yaml	EDEM1	Q92611	NCBITaxon:9606	Homo sapiens	23	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM1 ERQC localization in the mannose-trimming reaction context.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	10	R-HSA-901024	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901024.md	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM2 alpha-1,2-mannosidase activity in N-glycan mannose trimming. EDEM2 has demonstrated mannosidase activity catalyzing the first trimming step (Man9 to Man8B).
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	11	R-HSA-901036	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901036.md	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM2 alpha-1,2-mannosidase activity in N-glycan mannose trimming. EDEM2 has demonstrated mannosidase activity catalyzing the first trimming step (Man9 to Man8B).
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	12	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM2 alpha-1,2-mannosidase activity in N-glycan mannose trimming. EDEM2 has demonstrated mannosidase activity catalyzing the first trimming step (Man9 to Man8B).
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	13	R-HSA-901074	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-901074.md	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM2 alpha-1,2-mannosidase activity in N-glycan mannose trimming. EDEM2 has demonstrated mannosidase activity catalyzing the first trimming step (Man9 to Man8B).
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	14	R-HSA-9696807	N-glycan mannose trimming of Spike	yes	reactome/R-HSA-9696807.md	N-glycan mannose trimming of Spike	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM2 alpha-1,2-mannosidase activity in N-glycan mannose trimming. EDEM2 has demonstrated mannosidase activity catalyzing the first trimming step (Man9 to Man8B).
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	16	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		ACCEPT	Reactome curation of EDEM2 ER mannose trimming in the ER Quality Control Compartment pathway.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	19	R-HSA-9694548	Maturation of spike protein	yes	reactome/R-HSA-9694548.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation of EDEM2 in N-glycan mannose trimming of the SARS-CoV-2 spike glycoprotein. This is the generic mannosidase activity acting on a viral glycoprotein substrate, not a distinct viral function.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	20	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0036510	trimming of terminal mannose on C branch	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome curation of a specific terminal-mannose trimming sub-step. EDEM2 mainly initiates trimming on the B branch (Man9 to Man8B); this C-branch sub-step annotation is a Reactome-curated refinement.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	25	R-HSA-901024	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901024.md	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM2 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	26	R-HSA-901036	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901036.md	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM2 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	27	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM2 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	28	R-HSA-901074	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-901074.md	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM2 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EDEM2	genes/human/EDEM2/EDEM2-ai-review.yaml	EDEM2	Q9BV94	NCBITaxon:9606	Homo sapiens	29	R-HSA-9696807	N-glycan mannose trimming of Spike	yes	reactome/R-HSA-9696807.md	N-glycan mannose trimming of Spike	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM2 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EDEM3	genes/human/EDEM3/EDEM3-ai-review.yaml	EDEM3	Q9BZQ6	NCBITaxon:9606	Homo sapiens	13	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of EDEM3 (with EDEM1) hydrolysing Man8b to Man5 glycans, an accurate representation of EDEM3's downstream trimming activity.
human	EDEM3	genes/human/EDEM3/EDEM3-ai-review.yaml	EDEM3	Q9BZQ6	NCBITaxon:9606	Homo sapiens	17	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	TAS	involved_in	BP	false		ACCEPT	Reactome curation of EDEM3 mannose trimming within the glycoprotein ERAD pathway; an accurate, specific refinement of EDEM3's trimming contribution to ERAD.
human	EDEM3	genes/human/EDEM3/EDEM3-ai-review.yaml	EDEM3	Q9BZQ6	NCBITaxon:9606	Homo sapiens	19	R-HSA-6782685	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	yes	reactome/R-HSA-6782685.md	EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of EDEM3 localization to the ER-derived quality control compartment (ERQC), where mannose trimming of ERAD substrates occurs.
human	EEF2K	genes/human/EEF2K/EEF2K-ai-review.yaml	EEF2K	O00418	NCBITaxon:9606	Homo sapiens	26	R-HSA-165758	Reactome pathway involving EEF2K (cytosolic localization)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization, the principal compartment where EEF2K phosphorylates eEF2.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	185	R-HSA-212718	EGFR interacts with phospholipase C-gamma	yes	reactome/R-HSA-212718.md	EGFR interacts with phospholipase C-gamma	Homo sapiens	GO:0007165	signal transduction	TAS	involved_in	BP	false		ACCEPT	EGFR mediates signal transduction from extracellular growth factors to intracellular signaling cascades.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	186	R-HSA-177929	Signaling by EGFR	yes	reactome/R-HSA-177929.md	Signaling by EGFR	Homo sapiens	GO:0007173	epidermal growth factor receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	EGFR is the initiating receptor of the EGF receptor signaling pathway, binding EGF family ligands and activating downstream signaling cascades.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	187	R-HSA-182971	EGFR downregulation	yes	reactome/R-HSA-182971.md	EGFR downregulation	Homo sapiens	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	EGFR participates in negative regulation of its own signaling through internalization and degradation mechanisms.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	221	R-HSA-177930	GAB1 phosphorylation by EGFR kinase	yes	reactome/R-HSA-177930.md	GAB1 phosphorylation by EGFR kinase	Homo sapiens	GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR is a receptor tyrosine kinase (EC 2.7.10.1) that phosphorylates tyrosine residues on substrate proteins following ligand-induced dimerization. This is a core molecular function.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	222	R-HSA-177933	SHC1 phosphorylation by phosphorylated EGFR	yes	reactome/R-HSA-177933.md	SHC1 phosphorylation by phosphorylated EGFR	Homo sapiens	GO:0004714	transmembrane receptor protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR is a receptor tyrosine kinase (EC 2.7.10.1) that phosphorylates tyrosine residues on substrate proteins following ligand-induced dimerization. This is a core molecular function.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	244	R-HSA-177934	EGFR autophosphorylation	yes	reactome/R-HSA-177934.md	EGFR autophosphorylation	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR possesses protein tyrosine kinase activity, phosphorylating itself and downstream substrates upon activation.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	245	R-HSA-182969	Phosphorylation of CBL (EGFR:CBL)	yes	reactome/R-HSA-182969.md	Phosphorylation of CBL (EGFR:CBL)	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR possesses protein tyrosine kinase activity, phosphorylating itself and downstream substrates upon activation.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	246	R-HSA-183058	Phosphorylation of CBL (EGFR:GRB2:CBL)	yes	reactome/R-HSA-183058.md	Phosphorylation of CBL (EGFR:GRB2:CBL)	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR possesses protein tyrosine kinase activity, phosphorylating itself and downstream substrates upon activation.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	247	R-HSA-212710	EGFR activates PLC-gamma1 by phosphorylation	yes	reactome/R-HSA-212710.md	EGFR activates PLC-gamma1 by phosphorylation	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR possesses protein tyrosine kinase activity, phosphorylating itself and downstream substrates upon activation.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	248	R-HSA-8867041	EGFR phosphorylates EPS15	yes	reactome/R-HSA-8867041.md	EGFR phosphorylates EPS15	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	EGFR possesses protein tyrosine kinase activity, phosphorylating itself and downstream substrates upon activation.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	253	R-HSA-177935	SHP2 dephosphorylates Tyr 992 on EGFR	yes	reactome/R-HSA-177935.md	SHP2 dephosphorylates Tyr 992 on EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	254	R-HSA-8863804	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248	yes	reactome/R-HSA-8863804.md	PTPN12 dephosphorylates ERBB2 on tyrosine Y1248	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	255	R-HSA-8864029	PTPN12 dephosphorylates EGFR at Y1172 (Y1148)	yes	reactome/R-HSA-8864029.md	PTPN12 dephosphorylates EGFR at Y1172 (Y1148)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	281	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	282	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	283	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	284	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	285	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	286	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	287	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	EGFR undergoes clathrin-mediated endocytosis and localizes to clathrin-coated vesicles.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	291	R-HSA-1169421	Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers	yes	reactome/R-HSA-1169421.md	Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	292	R-HSA-1218833	Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37	yes	reactome/R-HSA-1218833.md	Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	293	R-HSA-1220610	Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants	yes	reactome/R-HSA-1220610.md	Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	294	R-HSA-1220612	Binding of EGF to ligand-responsive EGFR mutants	yes	reactome/R-HSA-1220612.md	Binding of EGF to ligand-responsive EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	295	R-HSA-1220613	EGF-induced dimerization of ligand-responsive EGFR mutants	yes	reactome/R-HSA-1220613.md	EGF-induced dimerization of ligand-responsive EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	296	R-HSA-1220614	Spontaneous dimerization of ligand-responsive EGFR mutants	yes	reactome/R-HSA-1220614.md	Spontaneous dimerization of ligand-responsive EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	297	R-HSA-1225947	Binding of SHC1 to p-6Y-EGFR mutants	yes	reactome/R-HSA-1225947.md	Binding of SHC1 to p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	298	R-HSA-1225949	Binding of CBL to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1225949.md	Binding of CBL to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	299	R-HSA-1225950	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	yes	reactome/R-HSA-1225950.md	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	300	R-HSA-1225951	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	301	R-HSA-1225952	Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1225952.md	Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	302	R-HSA-1225956	Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL	yes	reactome/R-HSA-1225956.md	Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	303	R-HSA-1225957	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	304	R-HSA-1225960	Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1225960.md	Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	305	R-HSA-1225961	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	yes	reactome/R-HSA-1225961.md	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	306	R-HSA-1226012	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226012.md	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	307	R-HSA-1226014	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226014.md	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	308	R-HSA-1226016	Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226016.md	Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	309	R-HSA-1247841	PLCG1 binds to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1247841.md	PLCG1 binds to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	310	R-HSA-1247842	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1247842.md	Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	311	R-HSA-1247844	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1247844.md	Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	312	R-HSA-1220611	Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors	yes	reactome/R-HSA-1220611.md	Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	314	R-HSA-9611147	Endocytic Uptake of HCMV Virion	yes	reactome/R-HSA-9611147.md	Endocytic Uptake of HCMV Virion	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	EGFR localizes to endosome membranes during receptor trafficking after internalization.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	352	R-HSA-1247999	EGFRvIII mutant binds chaperone proteins HSP90 and CDC37	yes	reactome/R-HSA-1247999.md	EGFRvIII mutant binds chaperone proteins HSP90 and CDC37	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	353	R-HSA-1248002	Ligand-independent dimerization of EGFRvIII mutant	yes	reactome/R-HSA-1248002.md	Ligand-independent dimerization of EGFRvIII mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	354	R-HSA-1248655	Trans-autophosphorylation of EGFRvIII mutant dimers	yes	reactome/R-HSA-1248655.md	Trans-autophosphorylation of EGFRvIII mutant dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	355	R-HSA-5637764	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant	yes	reactome/R-HSA-5637764.md	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	356	R-HSA-5637765	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	yes	reactome/R-HSA-5637765.md	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	357	R-HSA-5637766	Binding of SHC1 to p-5Y-EGFRvIII	yes	reactome/R-HSA-5637766.md	Binding of SHC1 to p-5Y-EGFRvIII	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	358	R-HSA-5637770	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637770.md	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	359	R-HSA-5637792	PLC-gamma 1 binds to p-EGFRvIII mutant	yes	reactome/R-HSA-5637792.md	PLC-gamma 1 binds to p-EGFRvIII mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	360	R-HSA-5637794	EGFRvIII does not bind CBL	yes	reactome/R-HSA-5637794.md	EGFRvIII does not bind CBL	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	361	R-HSA-5637795	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant	yes	reactome/R-HSA-5637795.md	Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	362	R-HSA-5637796	Phosphorylation of SHC1 by p-5Y-EGFRvIII	yes	reactome/R-HSA-5637796.md	Phosphorylation of SHC1 by p-5Y-EGFRvIII	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	363	R-HSA-5637798	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	yes	reactome/R-HSA-5637798.md	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	364	R-HSA-5637800	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant	yes	reactome/R-HSA-5637800.md	Dissociation of phosphorylated PLC-gamma 1 from p-EGFRvIII mutant	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	365	R-HSA-5637801	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637801.md	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	366	R-HSA-5637806	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	367	R-HSA-5637808	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	368	R-HSA-5638137	EGFRvIII cancer variant does not bind EGF ligand	yes	reactome/R-HSA-5638137.md	EGFRvIII cancer variant does not bind EGF ligand	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	369	R-HSA-1250195	SHC1 phosphorylation by ERBB2 heterodimers	yes	reactome/R-HSA-1250195.md	SHC1 phosphorylation by ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	370	R-HSA-1306957	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306957.md	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	371	R-HSA-1306963	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR	yes	reactome/R-HSA-1306963.md	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	372	R-HSA-1306965	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306965.md	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	373	R-HSA-177923	Sustained activation of SRC kinase by SHP2	yes	reactome/R-HSA-177923.md	Sustained activation of SRC kinase by SHP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	374	R-HSA-177924	Dephosphorylation of Gab1 by SHP2	yes	reactome/R-HSA-177924.md	Dephosphorylation of Gab1 by SHP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	375	R-HSA-177925	SHC1 binds to the phosphorylated EGF receptor:ligand complex	yes	reactome/R-HSA-177925.md	SHC1 binds to the phosphorylated EGF receptor:ligand complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	376	R-HSA-177926	Dephosphorylation of PAG by SHP2	yes	reactome/R-HSA-177926.md	Dephosphorylation of PAG by SHP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	377	R-HSA-177927	PI3K binds to EGF:EGFR:GRB2:GAB1	yes	reactome/R-HSA-177927.md	PI3K binds to EGF:EGFR:GRB2:GAB1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	378	R-HSA-177930	GAB1 phosphorylation by EGFR kinase	yes	reactome/R-HSA-177930.md	GAB1 phosphorylation by EGFR kinase	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	379	R-HSA-177933	SHC1 phosphorylation by phosphorylated EGFR	yes	reactome/R-HSA-177933.md	SHC1 phosphorylation by phosphorylated EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	380	R-HSA-177934	EGFR autophosphorylation	yes	reactome/R-HSA-177934.md	EGFR autophosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	381	R-HSA-177936	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	yes	reactome/R-HSA-177936.md	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	382	R-HSA-177937	Phosphorylation of EGFR by SRC kinase	yes	reactome/R-HSA-177937.md	Phosphorylation of EGFR by SRC kinase	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	383	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	384	R-HSA-177939	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	yes	reactome/R-HSA-177939.md	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	385	R-HSA-177941	GRB2:GAB1 binds to phosphorylated EGFR	yes	reactome/R-HSA-177941.md	GRB2:GAB1 binds to phosphorylated EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	386	R-HSA-177943	GRB2:SOS1 complex binds to EGF:EGFR complex	yes	reactome/R-HSA-177943.md	GRB2:SOS1 complex binds to EGF:EGFR complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	387	R-HSA-177944	Activation of SHP2 through the binding to phospho-Gab1	yes	reactome/R-HSA-177944.md	Activation of SHP2 through the binding to phospho-Gab1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	388	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	389	R-HSA-182969	Phosphorylation of CBL (EGFR:CBL)	yes	reactome/R-HSA-182969.md	Phosphorylation of CBL (EGFR:CBL)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	390	R-HSA-182986	CBL-mediated ubiquitination of CIN85	yes	reactome/R-HSA-182986.md	CBL-mediated ubiquitination of CIN85	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	391	R-HSA-182990	Sprouty sequesters CBL away from active EGFR	yes	reactome/R-HSA-182990.md	Sprouty sequesters CBL away from active EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	392	R-HSA-182993	Ubiquitination of stimulated EGFR (CBL)	yes	reactome/R-HSA-182993.md	Ubiquitination of stimulated EGFR (CBL)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	393	R-HSA-182994	Assembly of EGFR complex in clathrin-coated vesicles	yes	reactome/R-HSA-182994.md	Assembly of EGFR complex in clathrin-coated vesicles	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	394	R-HSA-183002	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85	yes	reactome/R-HSA-183002.md	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	395	R-HSA-183036	Ubiquitination of stimulated EGFR (CBL:GRB2)	yes	reactome/R-HSA-183036.md	Ubiquitination of stimulated EGFR (CBL:GRB2)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	396	R-HSA-183051	CBL ubiquitinates Sprouty	yes	reactome/R-HSA-183051.md	CBL ubiquitinates Sprouty	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	397	R-HSA-183055	Binding of CBL to EGFR	yes	reactome/R-HSA-183055.md	Binding of CBL to EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	398	R-HSA-183058	Phosphorylation of CBL (EGFR:GRB2:CBL)	yes	reactome/R-HSA-183058.md	Phosphorylation of CBL (EGFR:GRB2:CBL)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	399	R-HSA-183067	Localization of CBL:GRB2 to the membrane	yes	reactome/R-HSA-183067.md	Localization of CBL:GRB2 to the membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	400	R-HSA-183072	EGFR non-clathrin mediated endocytosis	yes	reactome/R-HSA-183072.md	EGFR non-clathrin mediated endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	401	R-HSA-183084	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix	yes	reactome/R-HSA-183084.md	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	402	R-HSA-183089	CBL binds and ubiquitinates phosphorylated Sprouty	yes	reactome/R-HSA-183089.md	CBL binds and ubiquitinates phosphorylated Sprouty	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	403	R-HSA-1963563	MATK (CSK homologous kinase) binds phosphorylated ERBB2	yes	reactome/R-HSA-1963563.md	MATK (CSK homologous kinase) binds phosphorylated ERBB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	404	R-HSA-1963581	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers	yes	reactome/R-HSA-1963581.md	Trans-autophosphorylation of p-Y877-ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	405	R-HSA-1963582	Trans-autophosphorylation of ERBB2 heterodimers	yes	reactome/R-HSA-1963582.md	Trans-autophosphorylation of ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	406	R-HSA-212706	Phospholipase C-gamma1 binds to the activated EGF receptor	yes	reactome/R-HSA-212706.md	Phospholipase C-gamma1 binds to the activated EGF receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	407	R-HSA-212710	EGFR activates PLC-gamma1 by phosphorylation	yes	reactome/R-HSA-212710.md	EGFR activates PLC-gamma1 by phosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	408	R-HSA-212713	Active PLC-gamma1 dissociates from EGFR	yes	reactome/R-HSA-212713.md	Active PLC-gamma1 dissociates from EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	409	R-HSA-2179387	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor	yes	reactome/R-HSA-2179387.md	Mature HBEGF binds to EGFR, triggering dimerisation and autophosphorylation of the receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	410	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	411	R-HSA-2179415	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	yes	reactome/R-HSA-2179415.md	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	412	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	413	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	414	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	415	R-HSA-6785636	Phosphorylated ERBB2 heterodimers bind MEMO1	yes	reactome/R-HSA-6785636.md	Phosphorylated ERBB2 heterodimers bind MEMO1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	416	R-HSA-6785648	MEMO1 binds RHOA:GTP:DIAPH1	yes	reactome/R-HSA-6785648.md	MEMO1 binds RHOA:GTP:DIAPH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	417	R-HSA-8847995	Activated ERBB2 binds PTK6 (BRK)	yes	reactome/R-HSA-8847995.md	Activated ERBB2 binds PTK6 (BRK)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	418	R-HSA-8848005	ERBB2 promotes PTK6 autophosphorylation	yes	reactome/R-HSA-8848005.md	ERBB2 promotes PTK6 autophosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	419	R-HSA-8864105	PTPN18 binds ERBB2:EGFR heterodimers	yes	reactome/R-HSA-8864105.md	PTPN18 binds ERBB2:EGFR heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	420	R-HSA-8864125	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248	yes	reactome/R-HSA-8864125.md	PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	421	R-HSA-8866279	Epsin family proteins bind ubiquitinated cargo	yes	reactome/R-HSA-8866279.md	Epsin family proteins bind ubiquitinated cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	422	R-HSA-8867041	EGFR phosphorylates EPS15	yes	reactome/R-HSA-8867041.md	EGFR phosphorylates EPS15	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	423	R-HSA-8867044	EGFR binds EPS15, EPN1, EPS15L1	yes	reactome/R-HSA-8867044.md	EGFR binds EPS15, EPN1, EPS15L1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	424	R-HSA-8867047	PTPN3 dephosphorylates EPS15	yes	reactome/R-HSA-8867047.md	PTPN3 dephosphorylates EPS15	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	425	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	426	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	427	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	428	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	429	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	430	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	431	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	432	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	433	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	434	R-HSA-8951490	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85	yes	reactome/R-HSA-8951490.md	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	435	R-HSA-9018572	EGFR phosphorylates NOTCH3	yes	reactome/R-HSA-9018572.md	EGFR phosphorylates NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	436	R-HSA-9018573	NOTCH3 binds activated EGFR	yes	reactome/R-HSA-9018573.md	NOTCH3 binds activated EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	437	R-HSA-9625482	PTK2 binds activated EGFR	yes	reactome/R-HSA-9625482.md	PTK2 binds activated EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	438	R-HSA-9625487	PTK2 autophosphorylates downstream of EGFR	yes	reactome/R-HSA-9625487.md	PTK2 autophosphorylates downstream of EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	439	R-HSA-9664588	ERBB2 KD mutants trans-autophosphorylate	yes	reactome/R-HSA-9664588.md	ERBB2 KD mutants trans-autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	440	R-HSA-9664918	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1	yes	reactome/R-HSA-9664918.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	441	R-HSA-9664933	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9664933.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	442	R-HSA-9664940	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9664940.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	443	R-HSA-9664950	Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1	yes	reactome/R-HSA-9664950.md	Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	444	R-HSA-9664976	Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1	yes	reactome/R-HSA-9664976.md	Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	445	R-HSA-9664983	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9664983.md	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	446	R-HSA-9664991	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	447	R-HSA-9665000	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665000.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	448	R-HSA-9665009	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	449	R-HSA-9665032	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1	yes	reactome/R-HSA-9665032.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	450	R-HSA-9665034	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1	yes	reactome/R-HSA-9665034.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	451	R-HSA-9665389	Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate	yes	reactome/R-HSA-9665389.md	Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	452	R-HSA-9665404	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	453	R-HSA-9665406	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1	yes	reactome/R-HSA-9665406.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	454	R-HSA-9665407	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9665407.md	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	455	R-HSA-9665408	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	456	R-HSA-9665409	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	yes	reactome/R-HSA-9665409.md	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	457	R-HSA-9665410	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1	yes	reactome/R-HSA-9665410.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	458	R-HSA-9665411	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1	yes	reactome/R-HSA-9665411.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	459	R-HSA-9665413	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665413.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	460	R-HSA-9665415	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9665415.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	461	R-HSA-9665416	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1	yes	reactome/R-HSA-9665416.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	462	R-HSA-9665417	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1	yes	reactome/R-HSA-9665417.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	463	R-HSA-9665698	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665698.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	464	R-HSA-9665699	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665699.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	465	R-HSA-9665700	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	466	R-HSA-9665701	Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1	yes	reactome/R-HSA-9665701.md	Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	467	R-HSA-9665704	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1	yes	reactome/R-HSA-9665704.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	468	R-HSA-9665705	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1	yes	reactome/R-HSA-9665705.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	469	R-HSA-9665706	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1	yes	reactome/R-HSA-9665706.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	470	R-HSA-9665707	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	471	R-HSA-9665709	ERBB2 TMD/JMD heterodimers trans-autophosphorylate	yes	reactome/R-HSA-9665709.md	ERBB2 TMD/JMD heterodimers trans-autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	472	R-NUL-1248744	Shc1 binds phosphorylated ERBB2:EGFR heterodimers	yes	reactome/R-NUL-1248744.md	Shc1 binds phosphorylated ERBB2:EGFR heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	473	R-NUL-1251923	Plcg1 binds P-ERBB2:P-EGFR	yes	reactome/R-NUL-1251923.md	Plcg1 binds P-ERBB2:P-EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	474	R-NUL-1251929	Plcg1 phosphorylation by P-ERBB2:P-EGFR	yes	reactome/R-NUL-1251929.md	Plcg1 phosphorylation by P-ERBB2:P-EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	506	R-HSA-1225978	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers	yes	reactome/R-HSA-1225978.md	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	507	R-HSA-1248677	Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody	yes	reactome/R-HSA-1248677.md	Inactivation of over-expressed wild type EGFR by Cetuximab recombinant antibody	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	508	R-HSA-177922	EGFR dimerization	yes	reactome/R-HSA-177922.md	EGFR dimerization	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	509	R-HSA-177942	EGFR binds EGF ligand	yes	reactome/R-HSA-177942.md	EGFR binds EGF ligand	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	510	R-HSA-1963586	SRC family kinases phosphorylate ERBB2	yes	reactome/R-HSA-1963586.md	SRC family kinases phosphorylate ERBB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	511	R-HSA-1963589	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4	yes	reactome/R-HSA-1963589.md	ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	512	R-HSA-1977959	ERBB4 forms heterodimers with EGFR	yes	reactome/R-HSA-1977959.md	ERBB4 forms heterodimers with EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	513	R-HSA-445069	L1-EGFR trans-heterodimerization	yes	reactome/R-HSA-445069.md	L1-EGFR trans-heterodimerization	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	514	R-HSA-8857549	HBEGF-bound EGFR forms a heterodimer with GPNMB	yes	reactome/R-HSA-8857549.md	HBEGF-bound EGFR forms a heterodimer with GPNMB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	515	R-HSA-8857555	EGFR phosphorylates GPNMB	yes	reactome/R-HSA-8857555.md	EGFR phosphorylates GPNMB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	516	R-HSA-8857565	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139	yes	reactome/R-HSA-8857565.md	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	517	R-HSA-8857577	LINC01139 facilitates PTK6 autophosphorylation	yes	reactome/R-HSA-8857577.md	LINC01139 facilitates PTK6 autophosphorylation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	518	R-HSA-8857583	LINC01139 promotes phosphorylation of HIF1A by PTK6	yes	reactome/R-HSA-8857583.md	LINC01139 promotes phosphorylation of HIF1A by PTK6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	519	R-HSA-8874797	EGFR gene expression is stimulated by TFAP2C	yes	reactome/R-HSA-8874797.md	EGFR gene expression is stimulated by TFAP2C	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	520	R-HSA-9609689	HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG)	yes	reactome/R-HSA-9609689.md	HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	521	R-HSA-9610867	HCMV Binds Host Cell Receptor - Endocytic Pathway	yes	reactome/R-HSA-9610867.md	HCMV Binds Host Cell Receptor - Endocytic Pathway	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	522	R-HSA-9611147	Endocytic Uptake of HCMV Virion	yes	reactome/R-HSA-9611147.md	Endocytic Uptake of HCMV Virion	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	523	R-HSA-9611158	Fusion of HCMV Envelope with Plasma Membrane	yes	reactome/R-HSA-9611158.md	Fusion of HCMV Envelope with Plasma Membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	524	R-HSA-9634702	LINC01139 promotes phosphorylation of HIF1A by LRRK2	yes	reactome/R-HSA-9634702.md	LINC01139 promotes phosphorylation of HIF1A by LRRK2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	525	R-HSA-9664567	ERBB2 KD mutants heterodimerize	yes	reactome/R-HSA-9664567.md	ERBB2 KD mutants heterodimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	526	R-HSA-9665388	ERBB2 ECD mutants heterodimerize with EGFR	yes	reactome/R-HSA-9665388.md	ERBB2 ECD mutants heterodimerize with EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	527	R-HSA-9665697	ERBB2 TMD/JMD mutants hetrodimerize	yes	reactome/R-HSA-9665697.md	ERBB2 TMD/JMD mutants hetrodimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	528	R-HSA-9674531	AAMP binds EGFR	yes	reactome/R-HSA-9674531.md	AAMP binds EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGFR	genes/human/EGFR/EGFR-ai-review.yaml	EGFR	P00533	NCBITaxon:9606	Homo sapiens	529	R-HSA-9851407	FAM83B, (FAM83A, FAM83D) bind EGFR	yes	reactome/R-HSA-9851407.md	FAM83B, (FAM83A, FAM83D) bind EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EGFR is a transmembrane receptor that localizes to the plasma membrane where it binds extracellular ligands and initiates intracellular signaling.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	49	R-HSA-9612073	NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression	yes	reactome/R-HSA-9612073.md	NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression. Places EGR2 in the nucleoplasm.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	50	R-HSA-9612483	EGR1,2,3 bind the NAB2 promoter	yes	reactome/R-HSA-9612483.md	EGR1,2,3 bind the NAB2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR1,2,3 binding the NAB2 promoter. EGR2 binds the NAB2 promoter in the nucleoplasm.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	51	R-HSA-9613210	EGR1, EGR2 bind the RRAD promoter	yes	reactome/R-HSA-9613210.md	EGR1, EGR2 bind the RRAD promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR1, EGR2 binding the RRAD promoter.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	52	R-HSA-9613213	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression	yes	reactome/R-HSA-9613213.md	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for NAB2 and CHD4 binding and repressing EGR-mediated RRAD gene expression.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	53	R-HSA-9613476	EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions	yes	reactome/R-HSA-9613476.md	EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2:NAB2 and CHD4 binding the ID2 and ID4 promoter regions.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	54	R-HSA-9613760	EGR2 gene expression	yes	reactome/R-HSA-9613760.md	EGR2 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2 gene expression.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	55	R-HSA-9616116	EGR2 and SOX10 bind the MAG gene	yes	reactome/R-HSA-9616116.md	EGR2 and SOX10 bind the MAG gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2 and SOX10 binding the MAG gene. This represents a well-characterized myelin gene target.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	56	R-HSA-9618559	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene	yes	reactome/R-HSA-9618559.md	EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2, SOX10 and TEAD1 binding enhancers in the PMP22 gene.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	57	R-HSA-9618725	SOX10, EGR2 and NAB proteins bind the GJB1 promoter	yes	reactome/R-HSA-9618725.md	SOX10, EGR2 and NAB proteins bind the GJB1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for SOX10, EGR2 and NAB proteins binding the GJB1 promoter.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	58	R-HSA-9621400	EGR2 and SREBF2 dimer bind SCD5 gene	yes	reactome/R-HSA-9621400.md	EGR2 and SREBF2 dimer bind SCD5 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2 and SREBF2 dimer binding SCD5 gene.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	59	R-HSA-9621406	EGR2 and SREBF2 dimer bind CYP51A1 gene	yes	reactome/R-HSA-9621406.md	EGR2 and SREBF2 dimer bind CYP51A1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2 and SREBF2 dimer binding CYP51A1 gene.
human	EGR2	genes/human/EGR2/EGR2-ai-review.yaml	EGR2	P11161	NCBITaxon:9606	Homo sapiens	60	R-HSA-9621411	EGR2 and SREBF2(1-484) dimer bind HMGCR gene	yes	reactome/R-HSA-9621411.md	EGR2 and SREBF2(1-484) dimer bind HMGCR gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for EGR2 and SREBF2(1-484) dimer binding HMGCR gene.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	25	R-HSA-390247	Beta-oxidation of very long chain fatty acids	yes	reactome/R-HSA-390247.md	Beta-oxidation of very long chain fatty acids	Homo sapiens	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	involved_in	BP	false		ACCEPT	Precise process term: the peroxisomal (acyl-CoA-oxidase-initiated) variant of fatty-acid beta-oxidation in which EHHADH catalyzes the hydratase and dehydrogenase steps. Accurately captures the pathway context; accepted.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	26	R-HSA-6809264	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA	yes	reactome/R-HSA-6809264.md	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA	Homo sapiens	GO:0003857	(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the core C-terminal dehydrogenase activity (dehydrogenation of 3-hydroxyhexacosanoyl-CoA); consistent with human IDA evidence.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	27	R-HSA-6809263	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA	yes	reactome/R-HSA-6809263.md	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA	Homo sapiens	GO:0018812	3-hydroxyacyl-CoA dehydratase activity	TAS	enables	MF	false		MODIFY	"Reactome labels EHHADH's step-2 hydration reaction as a ""dehydratase"" activity. This is the same reaction captured by the curated enoyl-CoA hydratase activity (GO:0004300), already annotated by IDA. Modify to the curated hydratase term."
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	38	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Cytosol annotation from the Reactome peroxisomal-protein-import pathway, representing the transient pre-import cargo state (PEX5-bound). The mature functional enzyme is in the peroxisomal matrix; over-annotated as a steady-state functional location.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	39	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Cytosol annotation from the Reactome peroxisomal-import docking/translocation step; represents the transient pre-import cargo state, not a steady-state functional location. Over-annotated.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	40	R-HSA-6809263	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA	yes	reactome/R-HSA-6809263.md	EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Peroxisomal matrix is the precise functional location of this soluble matrix beta-oxidation enzyme; more specific than ""peroxisome"" and consistent with IDA evidence. Accepted."
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	41	R-HSA-6809264	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA	yes	reactome/R-HSA-6809264.md	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix location (Reactome), consistent with the enzyme being a soluble matrix beta-oxidation protein; precise and supported. Accepted.
human	EHHADH	genes/human/EHHADH/EHHADH-ai-review.yaml	EHHADH	Q08426	NCBITaxon:9606	Homo sapiens	42	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix location (destination of the Reactome import pathway); the correct mature functional compartment for EHHADH. Accepted.
human	EIF2AK3	genes/human/EIF2AK3/EIF2AK3-ai-review.yaml	EIF2AK3	Q9NZJ5	NCBITaxon:9606	Homo sapiens	88	R-HSA-381086	Dissociation of PERK:BiP Heterodimer	yes	reactome/R-HSA-381086.md	Dissociation of PERK:BiP Heterodimer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	PERK is an ER-resident transmembrane protein; endoplasmic reticulum membrane is the correct core cellular component.
human	EIF2AK3	genes/human/EIF2AK3/EIF2AK3-ai-review.yaml	EIF2AK3	Q9NZJ5	NCBITaxon:9606	Homo sapiens	89	R-HSA-381087	Dimerization of PERK	yes	reactome/R-HSA-381087.md	Dimerization of PERK	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	PERK is an ER-resident transmembrane protein; endoplasmic reticulum membrane is the correct core cellular component.
human	EIF2AK3	genes/human/EIF2AK3/EIF2AK3-ai-review.yaml	EIF2AK3	Q9NZJ5	NCBITaxon:9606	Homo sapiens	90	R-HSA-381111	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK	yes	reactome/R-HSA-381111.md	EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	PERK is an ER-resident transmembrane protein; endoplasmic reticulum membrane is the correct core cellular component.
human	EIF2AK3	genes/human/EIF2AK3/EIF2AK3-ai-review.yaml	EIF2AK3	Q9NZJ5	NCBITaxon:9606	Homo sapiens	91	R-HSA-9921802	IFI6 binds HSPA5	yes	reactome/R-HSA-9921802.md	IFI6 binds HSPA5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	PERK is an ER-resident transmembrane protein; endoplasmic reticulum membrane is the correct core cellular component.
human	EIF2AK3	genes/human/EIF2AK3/EIF2AK3-ai-review.yaml	EIF2AK3	Q9NZJ5	NCBITaxon:9606	Homo sapiens	92	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	This Reactome-based cytosol placement reflects an EIF2AK3-ALK fusion context rather than wild-type PERK localization.
human	EIF2B4	genes/human/EIF2B4/EIF2B4-ai-review.yaml	EIF2B4	Q9UI10	NCBITaxon:9606	Homo sapiens	26	R-HSA-72670	Formation of eIF2:GDP:eIF2B intermediate	yes	reactome/R-HSA-72670.md	Formation of eIF2:GDP:eIF2B intermediate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for formation of eIF2:GDP:eIF2B intermediate, which occurs in the cytosol.
human	EIF2B4	genes/human/EIF2B4/EIF2B4-ai-review.yaml	EIF2B4	Q9UI10	NCBITaxon:9606	Homo sapiens	27	R-HSA-72722	eIF2 activation	yes	reactome/R-HSA-72722.md	eIF2 activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for eIF2 activation, which occurs in the cytosol.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	52	R-HSA-156808	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a closed-loop conformation	yes	reactome/R-HSA-156808.md	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for translation initiation complex formation. EIF3E is cytosolic where it functions in translation.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	53	R-HSA-156823	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	yes	reactome/R-HSA-156823.md	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation. Redundant cytosol annotation.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	54	R-HSA-157849	Formation of translation initiation complexes containing mRNA that does not circularize	yes	reactome/R-HSA-157849.md	Formation of translation initiation complexes containing mRNA that does not circularize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation. Redundant cytosol annotation.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	55	R-HSA-72619	eIF2-GTP is hydrolyzed, eIFs are released	yes	reactome/R-HSA-72619.md	eIF2:GTP is hydrolyzed, eIFs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for eIF2:GTP hydrolysis and eIF release.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	56	R-HSA-72621	Ribosomal scanning	yes	reactome/R-HSA-72621.md	Ribosomal scanning	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ribosomal scanning.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	57	R-HSA-72676	eIF3 and eIF1A bind to the 40S subunit	yes	reactome/R-HSA-72676.md	eIF3 and eIF1A bind to the 40S subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for eIF3 and eIF1A binding to 40S subunit.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	58	R-HSA-72691	Formation of the 43S pre-initiation complex	yes	reactome/R-HSA-72691.md	Formation of the 43S pre-initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for 43S pre-initiation complex formation.
human	EIF3E	genes/human/EIF3E/EIF3E-ai-review.yaml	EIF3E	P60228	NCBITaxon:9606	Homo sapiens	59	R-HSA-72697	Start codon recognition	yes	reactome/R-HSA-72697.md	Start codon recognition	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for start codon recognition.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	45	R-HSA-156808	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	yes	reactome/R-HSA-156808.md	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	46	R-HSA-156823	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	yes	reactome/R-HSA-156823.md	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	47	R-HSA-157849	Formation of translation initiation complexes containing mRNA that does not circularize	yes	reactome/R-HSA-157849.md	Formation of translation initiation complexes containing mRNA that does not circularize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	48	R-HSA-72619	eIF2:GTP is hydrolyzed, eIFs are released	yes	reactome/R-HSA-72619.md	eIF2:GTP is hydrolyzed, eIFs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	49	R-HSA-72621	Ribosomal scanning	yes	reactome/R-HSA-72621.md	Ribosomal scanning	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	50	R-HSA-72676	eIF3 and eIF1A bind to the 40S subunit	yes	reactome/R-HSA-72676.md	eIF3 and eIF1A bind to the 40S subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	51	R-HSA-72691	Formation of the 43S pre-initiation complex	yes	reactome/R-HSA-72691.md	Formation of the 43S pre-initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3G	genes/human/EIF3G/EIF3G-ai-review.yaml	EIF3G	O75821	NCBITaxon:9606	Homo sapiens	52	R-HSA-72697	Start codon recognition	yes	reactome/R-HSA-72697.md	Start codon recognition	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	EIF3G is present in the cytosol, where eIF3 assembles translation preinitiation complexes; the multiple Reactome records are redundant but biologically correct.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	22	R-HSA-156808	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-156808.md	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization for translation-initiation reactions.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	23	R-HSA-156823	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-156823.md	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	24	R-HSA-157849	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-157849.md	Formation of translation initiation complexes containing mRNA that does not circularize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	25	R-HSA-72619	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-72619.md	eIF2:GTP is hydrolyzed, eIFs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	26	R-HSA-72621	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-72621.md	Ribosomal scanning	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	27	R-HSA-72676	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-72676.md	eIF3 and eIF1A bind to the 40S subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	28	R-HSA-72691	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-72691.md	Formation of the 43S pre-initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF3J	genes/human/EIF3J/EIF3J-ai-review.yaml	EIF3J	O75822	NCBITaxon:9606	Homo sapiens	29	R-HSA-72697	Reactome translation-initiation reaction (cytosolic).	yes	reactome/R-HSA-72697.md	Start codon recognition	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF4E2	genes/human/EIF4E2/EIF4E2-ai-review.yaml	EIF4E2	O60573	NCBITaxon:9606	Homo sapiens	38	R-HSA-1678842	Reactome pathway annotation (cytosol localization)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome TAS). Consistent with 4EHP's cytosolic function.
human	EIF4E2	genes/human/EIF4E2/EIF4E2-ai-review.yaml	EIF4E2	O60573	NCBITaxon:9606	Homo sapiens	39	R-HSA-1678843	Reactome pathway annotation (cytosol localization)	yes	reactome/R-HSA-1678843.md	ISGylation of protein translation regulator 4EHP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol localization (Reactome TAS).
human	EIF5A	genes/human/EIF5A/EIF5A-ai-review.yaml	EIF5A	P63241	NCBITaxon:9606	Homo sapiens	30	R-HSA-204617	Hypusine synthesis from eIF5A-lysine (Reactome reaction).	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (hypusine synthesis pathway), consistent with the core compartment.
human	EIF5A	genes/human/EIF5A/EIF5A-ai-review.yaml	EIF5A	P63241	NCBITaxon:9606	Homo sapiens	31	R-HSA-204647	Hypusine synthesis from eIF5A-lysine (Reactome reaction).	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	EIF5A	genes/human/EIF5A/EIF5A-ai-review.yaml	EIF5A	P63241	NCBITaxon:9606	Homo sapiens	32	R-HSA-204662	Hypusine synthesis from eIF5A-lysine (Reactome reaction).	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, redundant with the other cytosol annotations.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	70	R-HSA-450387	HuR binds the CRM1 nuclear export machinery	yes	reactome/R-HSA-450387.md	HuR binds the CRM1 nuclear export machinery	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450387 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	71	R-HSA-450494	HuR binds mRNAs in the nucleus	yes	reactome/R-HSA-450494.md	HuR binds mRNAs in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450494 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	72	R-HSA-450533	PKCdelta phosphorylates HuR	yes	reactome/R-HSA-450533.md	PKCdelta phosphorylates HuR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450533 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	73	R-HSA-450550	PKCalpha phosphorylates HuR	yes	reactome/R-HSA-450550.md	PKCalpha phosphorylates HuR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450550 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	74	R-HSA-450595	HuR:mRNA complex translocates from the nucleus to the cytosol	yes	reactome/R-HSA-450595.md	HuR:mRNA complex translocates from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450595 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	75	R-HSA-517674	p-S158,221-HuR binds mRNA	yes	reactome/R-HSA-517674.md	p-S158,221-HuR binds mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-517674 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	76	R-HSA-517705	p-S318,221-HuR binds mRNA	yes	reactome/R-HSA-517705.md	p-S318,221-HuR binds mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-517705 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	77	R-HSA-9921507	NS5 interacts with Spliceosome	yes	reactome/R-HSA-9921507.md	NS5 interacts with Spliceosome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-9921507 associates ELAVL1 with nucleoplasm.
human	ELAVL1	genes/human/ELAVL1/ELAVL1-ai-review.yaml	ELAVL1	Q15717	NCBITaxon:9606	Homo sapiens	78	R-HSA-450595	HuR:mRNA complex translocates from the nucleus to the cytosol	yes	reactome/R-HSA-450595.md	HuR:mRNA complex translocates from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome:R-HSA-450595 associates ELAVL1 with cytosol.
human	ELAVL2	genes/human/ELAVL2/ELAVL2-ai-review.yaml	ELAVL2	Q12926	NCBITaxon:9606	Homo sapiens	8	R-HSA-9921507	NS5 interacts with Spliceosome	yes	reactome/R-HSA-9921507.md	NS5 interacts with Spliceosome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome transfers a nucleoplasm location from a dengue-virus NS5/spliceosome event.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	64	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	65	R-HSA-1234163	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234163.md	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	66	R-HSA-1234173	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	yes	reactome/R-HSA-1234173.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	67	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	68	R-HSA-1234177	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	yes	reactome/R-HSA-1234177.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	69	R-HSA-1234183	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234183.md	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	70	R-HSA-180540	Multi-ubiquitination of APOBEC3G	yes	reactome/R-HSA-180540.md	Multi-ubiquitination of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	71	R-HSA-180555	Association of APOBEC3G:Vif with the Cul5-SCF complex	yes	reactome/R-HSA-180555.md	Association of APOBEC3G:Vif with the Cul5-SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	72	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	73	R-HSA-8952039	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952039.md	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	74	R-HSA-8952044	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952044.md	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	75	R-HSA-8952625	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952625.md	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	76	R-HSA-8952626	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952626.md	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	77	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	78	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	79	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	80	R-HSA-8956099	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	yes	reactome/R-HSA-8956099.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	81	R-HSA-8956103	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-8956103.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	82	R-HSA-8956106	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-8956106.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	83	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	84	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	85	R-HSA-9833107	Association of NS1 (1C) with Cul5 and SCF	yes	reactome/R-HSA-9833107.md	Association of NS1 (1C) with Cul5 and SCF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	86	R-HSA-9833155	Ubiquitination of STAT2	yes	reactome/R-HSA-9833155.md	Ubiquitination of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	87	R-HSA-9954721	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	yes	reactome/R-HSA-9954721.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	88	R-HSA-9954723	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	yes	reactome/R-HSA-9954723.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported broad localization for cytosolic CRL/adaptor contexts, including VHL/CRL and viral/SOCS-box ligase assemblies.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	89	R-HSA-112379	Recruitment of elongation factors to form elongation complex	yes	reactome/R-HSA-112379.md	Recruitment of elongation factors to form elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	90	R-HSA-112385	Addition of nucleotides leads to transcript elongation	yes	reactome/R-HSA-112385.md	Addition of nucleotides leads to transcript elongation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	91	R-HSA-112392	Resumption of elongation after recovery from pausing	yes	reactome/R-HSA-112392.md	Resumption of elongation after recovery from pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	92	R-HSA-112395	Abortive termination of elongation after arrest	yes	reactome/R-HSA-112395.md	Abortive termination of elongation after arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	93	R-HSA-112396	Separation of elongating transcript from template	yes	reactome/R-HSA-112396.md	Separation of elongating transcript from template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	94	R-HSA-112435	Formation of Elongin BC complex	yes	reactome/R-HSA-112435.md	Formation of Elongin BC complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	95	R-HSA-112436	Formation of Elongin complex	yes	reactome/R-HSA-112436.md	Formation of Elongin complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	96	R-HSA-113411	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	yes	reactome/R-HSA-113411.md	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	97	R-HSA-113412	Pol II elongation complex moves on the template as transcript elongates	yes	reactome/R-HSA-113412.md	Pol II elongation complex moves on the template as transcript elongates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	98	R-HSA-113413	TFIIS-mediated recovery of elongation from arrest	yes	reactome/R-HSA-113413.md	TFIIS-mediated recovery of elongation from arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	99	R-HSA-113414	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	yes	reactome/R-HSA-113414.md	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	100	R-HSA-113429	Elongating transcript encounters a lesion in the template	yes	reactome/R-HSA-113429.md	Elongating transcript encounters a lesion in the template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	101	R-HSA-1234169	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234169.md	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	102	R-HSA-1234172	Nuclear VBC complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-1234172.md	Nuclear VBC complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	103	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	104	R-HSA-6797606	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	yes	reactome/R-HSA-6797606.md	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOB	genes/human/ELOB/ELOB-ai-review.yaml	ELOB	Q15370	NCBITaxon:9606	Homo sapiens	105	R-HSA-6797616	CCNK:CDK12 binds RNA Pol II at DNA repair genes	yes	reactome/R-HSA-6797616.md	CCNK:CDK12 binds RNA Pol II at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported localization for nuclear Elongin/CRL functions, including RNA polymerase II elongation and nuclear cGAS turnover contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	76	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	77	R-HSA-1234163	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234163.md	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	78	R-HSA-1234173	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	yes	reactome/R-HSA-1234173.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	79	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	80	R-HSA-1234177	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	yes	reactome/R-HSA-1234177.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	81	R-HSA-1234183	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234183.md	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	82	R-HSA-180540	Multi-ubiquitination of APOBEC3G	yes	reactome/R-HSA-180540.md	Multi-ubiquitination of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	83	R-HSA-180555	Association of APOBEC3G:Vif with the Cul5-SCF complex	yes	reactome/R-HSA-180555.md	Association of APOBEC3G:Vif with the Cul5-SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	84	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	85	R-HSA-8952039	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952039.md	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	86	R-HSA-8952044	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952044.md	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	87	R-HSA-8952625	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952625.md	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	88	R-HSA-8952626	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952626.md	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	89	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	90	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	91	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	92	R-HSA-8956099	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	yes	reactome/R-HSA-8956099.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	93	R-HSA-8956103	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-8956103.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	94	R-HSA-8956106	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-8956106.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	95	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	96	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	97	R-HSA-9833107	Association of NS1 (1C) with Cul5 and SCF	yes	reactome/R-HSA-9833107.md	Association of NS1 (1C) with Cul5 and SCF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	98	R-HSA-9833155	Ubiquitination of STAT2	yes	reactome/R-HSA-9833155.md	Ubiquitination of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	99	R-HSA-9954721	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	yes	reactome/R-HSA-9954721.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	100	R-HSA-9954723	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	yes	reactome/R-HSA-9954723.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported. ELOC-containing CRL2/CRL5 complexes and their substrate receptor assemblies operate in cytosolic as well as nuclear contexts.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	101	R-HSA-112379	Recruitment of elongation factors to form elongation complex	yes	reactome/R-HSA-112379.md	Recruitment of elongation factors to form elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	102	R-HSA-112385	Addition of nucleotides leads to transcript elongation	yes	reactome/R-HSA-112385.md	Addition of nucleotides leads to transcript elongation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	103	R-HSA-112392	Resumption of elongation after recovery from pausing	yes	reactome/R-HSA-112392.md	Resumption of elongation after recovery from pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	104	R-HSA-112395	Abortive termination of elongation after arrest	yes	reactome/R-HSA-112395.md	Abortive termination of elongation after arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	105	R-HSA-112396	Separation of elongating transcript from template	yes	reactome/R-HSA-112396.md	Separation of elongating transcript from template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	106	R-HSA-112435	Formation of Elongin BC complex	yes	reactome/R-HSA-112435.md	Formation of Elongin BC complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	107	R-HSA-112436	Formation of Elongin complex	yes	reactome/R-HSA-112436.md	Formation of Elongin complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	108	R-HSA-113411	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	yes	reactome/R-HSA-113411.md	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	109	R-HSA-113412	Pol II elongation complex moves on the template as transcript elongates	yes	reactome/R-HSA-113412.md	Pol II elongation complex moves on the template as transcript elongates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	110	R-HSA-113413	TFIIS-mediated recovery of elongation from arrest	yes	reactome/R-HSA-113413.md	TFIIS-mediated recovery of elongation from arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	111	R-HSA-113414	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	yes	reactome/R-HSA-113414.md	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	112	R-HSA-113429	Elongating transcript encounters a lesion in the template	yes	reactome/R-HSA-113429.md	Elongating transcript encounters a lesion in the template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	113	R-HSA-1234169	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234169.md	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	114	R-HSA-1234172	Nuclear VBC complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-1234172.md	Nuclear VBC complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	115	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	116	R-HSA-6797606	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	yes	reactome/R-HSA-6797606.md	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOC	genes/human/ELOC/ELOC-ai-review.yaml	ELOC	Q15369	NCBITaxon:9606	Homo sapiens	117	R-HSA-6797616	CCNK:CDK12 binds RNA Pol II at DNA repair genes	yes	reactome/R-HSA-6797616.md	CCNK:CDK12 binds RNA Pol II at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported. ELOC has a prominent nuclear/nucleoplasmic pool consistent with Elongin transcriptional and nuclear CRL functions.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	22	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Defensible Reactome grouping (Synthesis of very long-chain fatty acyl-CoAs). Consistent with ELOVL1 catalysis; more specific VLCFA terms preferred. Non-core.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	23	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places all four ELOVLs generically in the n-3 PUFA (ALA) elongation pathway. ELOVL1 is specific for saturated/monounsaturated VLCFAs and is not the principal PUFA (ALA) elongase (ELOVL2/ELOVL5), so this pathway context is peripheral for ELOVL1. Not removed (TAS); non-core.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	24	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	As with the ALA term, Reactome groups all four ELOVLs into the n-6 PUFA (LA) elongation pathway. ELOVL1 acts on saturated/monounsaturated VLCFAs and is not the principal linoleic-acid/PUFA elongase; peripheral pathway context. Not removed (TAS); non-core.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	36	R-HSA-2046088	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	yes	reactome/R-HSA-2046088.md	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization (Reactome elongation reaction). Consistent with UniProt.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	37	R-HSA-2046094	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	yes	reactome/R-HSA-2046094.md	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization (Reactome elongation reaction). Consistent with UniProt.
human	ELOVL1	genes/human/ELOVL1/ELOVL1-ai-review.yaml	ELOVL1	Q9BW60	NCBITaxon:9606	Homo sapiens	38	R-HSA-548800	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	yes	reactome/R-HSA-548800.md	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization (Reactome: ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA). Consistent with UniProt.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	18	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		ACCEPT	ELOVL2 directly performs long-chain fatty-acyl-CoA biosynthesis.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	19	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	ELOVL2 performs elongation steps within alpha-linolenic-acid-derived omega-3 metabolism.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	20	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	ELOVL2 performs elongation steps within linoleic-acid-derived omega-6 metabolism.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	22	R-HSA-2046083	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	yes	reactome/R-HSA-2046083.md	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the elongase condensation reaction (elongation of arachidonyl-CoA). Correct core molecular function; redundant with the experimental annotations.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	23	R-HSA-2046090	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA	yes	reactome/R-HSA-2046090.md	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for an ELOVL2 elongation reaction (docosapentaenoyl-CoA -> tetracosapentaenoyl-CoA). Correct core molecular function; redundant with the experimental annotations.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	24	R-HSA-2046095	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA	yes	reactome/R-HSA-2046095.md	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for an ELOVL2 elongation reaction (docosatetraenoyl-CoA -> tetracosatetraenoyl-CoA). Correct core molecular function; redundant with the experimental annotations.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	25	R-HSA-2046100	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	yes	reactome/R-HSA-2046100.md	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for an ELOVL2 elongation reaction (eicosapentaenoyl-CoA -> docosapentaenoyl-CoA). Correct core molecular function; redundant with the experimental annotations.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	31	R-HSA-2046083	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	yes	reactome/R-HSA-2046083.md	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	32	R-HSA-2046088	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	yes	reactome/R-HSA-2046088.md	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	33	R-HSA-2046090	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA	yes	reactome/R-HSA-2046090.md	Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	34	R-HSA-2046094	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	yes	reactome/R-HSA-2046094.md	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	35	R-HSA-2046095	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA	yes	reactome/R-HSA-2046095.md	Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	36	R-HSA-2046100	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	yes	reactome/R-HSA-2046100.md	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL2	genes/human/ELOVL2/ELOVL2-ai-review.yaml	ELOVL2	Q9NXB9	NCBITaxon:9606	Homo sapiens	37	R-HSA-548800	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	yes	reactome/R-HSA-548800.md	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL2 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	20	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome pathway ""Synthesis of very long-chain fatty acyl-CoAs"". Correct but general pathway-level term; keep as non-core."
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	21	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places ELOVL3 in ALA (n-3 PUFA) metabolism, reflecting its ability to elongate C18:3 n-3 acyl-CoA. A pathway-context annotation for a secondary substrate; keep as non-core.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	22	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places ELOVL3 in LA (n-6 PUFA) metabolism, reflecting elongation of C18:2 n-6 acyl-CoA. Pathway-context annotation for a secondary substrate; keep as non-core.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	24	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA"" supports the core elongase MF (palmitoyl-CoA + malonyl-CoA condensation). Accept."
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	30	R-HSA-2046088	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	yes	reactome/R-HSA-2046088.md	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane location (Reactome). Redundant with the experimentally supported annotation; accept.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	31	R-HSA-2046094	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	yes	reactome/R-HSA-2046094.md	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane location (Reactome). Redundant duplicate; accept.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	32	R-HSA-548800	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	yes	reactome/R-HSA-548800.md	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane location (Reactome). Redundant duplicate; accept.
human	ELOVL3	genes/human/ELOVL3/ELOVL3-ai-review.yaml	ELOVL3	Q9HB03	NCBITaxon:9606	Homo sapiens	33	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct ER membrane location (Reactome). Redundant duplicate; accept.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	26	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome pathway annotation for VLCFA-CoA synthesis. ELOVL5 is annotated to the ""Synthesis of very long-chain fatty acyl-CoAs"" pathway."
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	27	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway for ALA (18:3n-3) metabolism. ELOVL5 elongates ALA-derived intermediates in the n-3 PUFA synthesis pathway.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	28	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway for LA (18:2n-6) metabolism. ELOVL5 elongates LA-derived intermediates including GLA to DGLA in the n-6 PUFA synthesis pathway.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	30	R-HSA-2046083	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	yes	reactome/R-HSA-2046083.md	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction annotation for elongation of arachidonyl-CoA to docosatetraenoyl-CoA.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	31	R-HSA-2046100	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	yes	reactome/R-HSA-2046100.md	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction annotation for elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	37	R-HSA-2046083	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	yes	reactome/R-HSA-2046083.md	Elongation of arachidonyl-CoA to docosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction annotation specifying ER membrane as reaction location.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	38	R-HSA-2046088	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	yes	reactome/R-HSA-2046088.md	Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction annotation for stearidonoyl-CoA elongation.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	39	R-HSA-2046094	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	yes	reactome/R-HSA-2046094.md	Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction annotation for gamma-linolenoyl-CoA elongation.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	40	R-HSA-2046100	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	yes	reactome/R-HSA-2046100.md	Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction annotation for eicosapentaenoyl-CoA elongation.
human	ELOVL5	genes/human/ELOVL5/ELOVL5-ai-review.yaml	ELOVL5	Q9NYP7	NCBITaxon:9606	Homo sapiens	41	R-HSA-548800	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	yes	reactome/R-HSA-548800.md	ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction annotation for arachidonate elongation.
human	ELOVL6	genes/human/ELOVL6/ELOVL6-ai-review.yaml	ELOVL6	Q9H5J4	NCBITaxon:9606	Homo sapiens	20	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation for synthesis of long-chain/very-long-chain fatty-acyl-CoAs; ELOVL6 produces long-chain (C18) acyl-CoAs. Accurate higher-level process.
human	ELOVL6	genes/human/ELOVL6/ELOVL6-ai-review.yaml	ELOVL6	Q9H5J4	NCBITaxon:9606	Homo sapiens	22	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	Core molecular function, Reactome-traceable (ELOVL3,6,7 condense palmitoyl-CoA with malonyl-CoA to 3-oxooctadecanoyl-CoA). Correct.
human	ELOVL6	genes/human/ELOVL6/ELOVL6-ai-review.yaml	ELOVL6	Q9H5J4	NCBITaxon:9606	Homo sapiens	31	R-HSA-1655835	Expression of ELOVL6	yes	reactome/R-HSA-1655835.md	Expression of ELOVL6	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL6 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL6	genes/human/ELOVL6/ELOVL6-ai-review.yaml	ELOVL6	Q9H5J4	NCBITaxon:9606	Homo sapiens	32	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ELOVL6 is a multipass endoplasmic-reticulum membrane elongase; this location is supported.
human	ELOVL7	genes/human/ELOVL7/ELOVL7-ai-review.yaml	ELOVL7	A1L3X0	NCBITaxon:9606	Homo sapiens	21	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"TAS from Reactome pathway ""Synthesis of very long-chain fatty acyl-CoAs"". ELOVL7 performs the condensation step of this pathway; the products are acyl-CoAs. Correct but a generic/parallel framing of the elongase activity; keep as non-core."
human	ELOVL7	genes/human/ELOVL7/ELOVL7-ai-review.yaml	ELOVL7	A1L3X0	NCBITaxon:9606	Homo sapiens	24	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0009922	fatty acid elongase activity	TAS	enables	MF	false		ACCEPT	"TAS from Reactome reaction ""ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA"". Correctly asserts the core condensing (elongase) activity of ELOVL7 on palmitoyl-CoA + malonyl-CoA. Accept."
human	ELOVL7	genes/human/ELOVL7/ELOVL7-ai-review.yaml	ELOVL7	A1L3X0	NCBITaxon:9606	Homo sapiens	30	R-HSA-548814	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	yes	reactome/R-HSA-548814.md	ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome; ER-membrane localization consistent with experimental evidence and UniProt. Accept.
human	ELOVL7	genes/human/ELOVL7/ELOVL7-ai-review.yaml	ELOVL7	A1L3X0	NCBITaxon:9606	Homo sapiens	31	R-HSA-548815	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA	yes	reactome/R-HSA-548815.md	ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA""; ER-membrane localization consistent with experimental evidence. Accept."
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	14	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing ENO3 (as part of the enolase dimers) in the Gluconeogenesis pathway, catalysing the hydration of PEP to 2-PG.
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	15	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing ENO3 in the Glycolysis pathway (canonical glycolysis).
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	16	R-HSA-70494	Enolase dimers (ENO1,2,3) convert PEP to 2PG	yes	reactome/R-HSA-70494.md	Enolase dimers (ENO1,2,3) convert PEP to 2PG	Homo sapiens	GO:0004634	phosphopyruvate hydratase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable-author-statement for the enolase reaction (""Enolase dimers (ENO1,2,3) convert PEP to 2PG""), assigning phosphopyruvate hydratase activity to ENO3."
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	17	R-HSA-71660	Enolase dimers dehydrates 2PG	yes	reactome/R-HSA-71660.md	Enolase dimers dehydrates 2PG	Homo sapiens	GO:0004634	phosphopyruvate hydratase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable-author-statement (""Enolase dimers dehydrates 2PG"") for the phosphopyruvate hydratase activity of ENO3."
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	24	R-HSA-70494	Enolase dimers (ENO1,2,3) convert PEP to 2PG	yes	reactome/R-HSA-70494.md	Enolase dimers (ENO1,2,3) convert PEP to 2PG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing the ENO3-containing enolase reaction to the cytosol.
human	ENO3	genes/human/ENO3/ENO3-ai-review.yaml	ENO3	P13929	NCBITaxon:9606	Homo sapiens	25	R-HSA-71660	Enolase dimers dehydrates 2PG	yes	reactome/R-HSA-71660.md	Enolase dimers dehydrates 2PG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing the ENO3 enolase reaction to the cytosol.
human	ENPP4	genes/human/ENPP4/ENPP4-ai-review.yaml	ENPP4	Q9Y6X5	NCBITaxon:9606	Homo sapiens	8	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome pathway for ficolin granule exocytosis.
human	ENPP4	genes/human/ENPP4/ENPP4-ai-review.yaml	ENPP4	Q9Y6X5	NCBITaxon:9606	Homo sapiens	9	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		UNDECIDED	"Ficolin-1-rich granule membrane localization. The Reactome source pathway R-HSA-6800426 is a neutrophil pathway, but the primary literature on ENPP4 (Borza 2022, Imam 2024) characterizes it as an endothelial-surface AP3A/AP4A hydrolase and provides no neutrophil- granule evidence. The supporting text from the perplexity deep research uses hedged language (""potentially in specialized membrane microdomains""), which does not justify an ACCEPT. Downgrading to UNDECIDED per PR #686 review feedback pending direct evidence for neutrophil granule localization of ENPP4."
human	ENPP7	genes/human/ENPP7/ENPP7-ai-review.yaml	ENPP7	Q6UWV6	NCBITaxon:9606	Homo sapiens	8	R-HSA-9840310	Glycosphingolipid catabolism	yes	reactome/R-HSA-9840310.md	Glycosphingolipid catabolism	Homo sapiens	GO:0046479	glycosphingolipid catabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Glycosphingolipid catabolic process from Reactome pathway annotation. Sphingomyelin is NOT a glycosphingolipid (it has a phosphocholine headgroup, not a carbohydrate), so this term is a mis-classification of ENPP7's actual reaction. The Reactome source pathway R-HSA-9840310 describes lysosomal ganglioside catabolism, not intestinal sphingomyelin hydrolysis. A more accurate process term is GO:0006684 (sphingomyelin metabolic process).
human	ENPP7	genes/human/ENPP7/ENPP7-ai-review.yaml	ENPP7	Q6UWV6	NCBITaxon:9606	Homo sapiens	9	R-HSA-1640164	ENPP7 hydrolyzes sphingomyelin	yes	reactome/R-HSA-1640164.md	ENPP7 hydrolyzes sphingomyelin	Homo sapiens	GO:0004767	sphingomyelin phosphodiesterase activity	TAS	enables	MF	false		ACCEPT	Sphingomyelin phosphodiesterase activity from Reactome pathway - ENPP7 hydrolyzes sphingomyelin.
human	ENPP7	genes/human/ENPP7/ENPP7-ai-review.yaml	ENPP7	Q6UWV6	NCBITaxon:9606	Homo sapiens	22	R-HSA-1640164	ENPP7 hydrolyzes sphingomyelin	yes	reactome/R-HSA-1640164.md	ENPP7 hydrolyzes sphingomyelin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome pathway for ENPP7 sphingomyelin hydrolysis.
human	ENSA	genes/human/ENSA/ENSA-ai-review.yaml	ENSA	O43768	NCBITaxon:9606	Homo sapiens	7	R-HSA-2430535	MASTL phosphorylates ENSA	yes	reactome/R-HSA-2430535.md	MASTL phosphorylates ENSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the MASTL-ENSA Ser67 phosphorylation reaction in the nucleoplasm; consistent with the nuclear pool of ENSA seen in human cells, which increases in S phase alongside nuclear active Greatwall.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	23	R-HSA-3928578	EPH receptors autophosphorylate	yes	reactome/R-HSA-3928578.md	EPH receptors autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	24	R-HSA-3928604	SFKs phosphorylate VAV2,3	yes	reactome/R-HSA-3928604.md	SFKs phosphorylate VAV2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	25	R-HSA-3928607	p-EPHs bind VAV2,3	yes	reactome/R-HSA-3928607.md	p-EPHs bind VAV2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	26	R-HSA-3928628	VAV exchanges GTP for GDP on RAC1, activating it	yes	reactome/R-HSA-3928628.md	VAV exchanges GTP for GDP on RAC1, activating it	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	27	R-HSA-3928642	TIAM1 exchanges GTP for GDP on RAC1, activating it	yes	reactome/R-HSA-3928642.md	TIAM1 exchanges GTP for GDP on RAC1, activating it	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	28	R-HSA-3928651	NGEF exchanges GTP for GDP on RHOA	yes	reactome/R-HSA-3928651.md	NGEF exchanges GTP for GDP on RHOA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	29	R-HSA-4093327	EPHA binds TIAM1	yes	reactome/R-HSA-4093327.md	EPHA binds TIAM1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	30	R-HSA-3928591	EPH:EFN tetramers oligomerise	yes	reactome/R-HSA-3928591.md	EPH:EFN tetramers oligomerise	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	31	R-HSA-3928597	EPH:EFN dimers tetramerise	yes	reactome/R-HSA-3928597.md	EPH:EFN dimers tetramerise	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	32	R-HSA-3928646	EPHAs bind EFNAs	yes	reactome/R-HSA-3928646.md	EPHAs bind EFNAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	EPHA1	genes/human/EPHA1/EPHA1-ai-review.yaml	EPHA1	P21709	NCBITaxon:9606	Homo sapiens	33	R-HSA-480509	Expression of EPHA1	yes	reactome/R-HSA-480509.md	Expression of EPHA1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	EPHA1 is a plasma-membrane Eph receptor tyrosine kinase that binds ephrin ligands and signals through ligand-dependent kinase activation/autophosphorylation.
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	53	R-HSA-109955	Formation of ERCC1:XPF heterodimeric complex	yes	reactome/R-HSA-109955.md	Formation of ERCC1:XPF heterodimeric complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; formation of the ERCC1:XPF complex).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	54	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; ERCC1:XPF cleaves SSA flaps).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	55	R-HSA-5686663	Completion of SSA	yes	reactome/R-HSA-5686663.md	Completion of SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; completion of SSA).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	56	R-HSA-5690213	DNA polymerases delta, epsilon or kappa bind the GG-NER site	yes	reactome/R-HSA-5690213.md	DNA polymerases delta, epsilon or kappa bind the GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; GG-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	57	R-HSA-5690988	3'-incision of DNA by ERCC5 (XPG) in GG-NER	yes	reactome/R-HSA-5690988.md	3'-incision of DNA by ERCC5 (XPG) in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; 3'-incision by XPG in GG-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	58	R-HSA-5690990	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	yes	reactome/R-HSA-5690990.md	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; 5'-incision by ERCC1:ERCC4 in GG-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	59	R-HSA-5690991	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	yes	reactome/R-HSA-5690991.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; binding of ERCC1:ERCC4 to GG-NER pre-incision complex).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	60	R-HSA-6782141	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	yes	reactome/R-HSA-6782141.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; ERCC1:ERCC4 binding in TC-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	61	R-HSA-6782204	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	yes	reactome/R-HSA-6782204.md	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; 5' incision by ERCC1:ERCC4 in TC-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	62	R-HSA-6782211	DNA polymerases delta, epsilon or kappa bind the TC-NER site	yes	reactome/R-HSA-6782211.md	DNA polymerases delta, epsilon or kappa bind the TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; TC-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	63	R-HSA-6782224	3' incision by ERCC5 (XPG) in TC-NER	yes	reactome/R-HSA-6782224.md	3' incision by ERCC5 (XPG) in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; 3' incision by XPG in TC-NER).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	64	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; DNA nucleases bind monoubiquitinated ID2 in FA pathway).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	65	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; DNA nucleases unhook the ICL).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	66	R-HSA-9980006	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	yes	reactome/R-HSA-9980006.md	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; ERCC1:XPF binds DSBs with SSA overhangs/flaps).
human	ERCC4	genes/human/ERCC4/ERCC4-ai-review.yaml	ERCC4	Q92889	NCBITaxon:9606	Homo sapiens	67	R-HSA-9980021	LIG1 binds SSA sites	yes	reactome/R-HSA-9980021.md	LIG1 binds SSA sites	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome; LIG1 binds SSA sites).
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	10	R-HSA-5362412	SYVN1 ubiquitinates Hh C-terminal fragments	yes	reactome/R-HSA-5362412.md	SYVN1 ubiquitinates Hh C-terminal fragments	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5362412: SYVN1 ubiquitinates Hh C-terminal fragments) placing ERLEC1 in the ER quality control compartment (ERQC). The ERQC is a pericentriolar ER-derived compartment where ERAD machinery concentrates along with misfolded substrates. Groisman et al. (PMID:21062743) showed that XTP3-B associates with ERAD substrates and E3 ligases in a mannose-trimming-dependent manner, consistent with localization to the ERQC. The Reactome entry describes ERLEC1 as a lectin in the ERAD machinery that helps target Hedgehog C-terminal fragments for degradation. This is a reasonable localization annotation for ERLEC1 given its role in ERAD substrate recognition.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	11	R-HSA-5362437	C-terminal Hh fragments are bound by lectins	yes	reactome/R-HSA-5362437.md	C-terminal Hh fragments are bound by lectins	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5362437: C-terminal Hh fragments are bound by lectins). This Reactome entry explicitly states that depletion of OS9 and ERLEC1 abrogates degradation of Hh-C fragments, and that they may target Hh-C to the retrotranslocation channel via interaction with SEL1. ERQC localization is appropriate for ERLEC1 given its established role as an ERAD lectin cargo receptor.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	12	R-HSA-5362441	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	yes	reactome/R-HSA-5362441.md	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5362441: C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane). ERLEC1 participates in recruiting substrates to the SEL1L-SYVN1 complex at the ER membrane, consistent with ERQC localization.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	13	R-HSA-5362450	Hh processing variants bind lectins	yes	reactome/R-HSA-5362450.md	Hh processing variants bind lectins	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5362450: Hh processing variants bind lectins). This entry describes how OS9 and ERLEC1 lectins are required for degradation of Hh processing-defective variants via the ERAD pathway, consistent with ERQC localization.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	14	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	yes	reactome/R-HSA-5362459.md	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5362459: VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol). ERLEC1 is part of the ERAD machinery that operates within the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	15	R-HSA-5387386	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	yes	reactome/R-HSA-5387386.md	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5387386: Hh processing variants are recruited to SEL1:SYVN at the ER membrane). ERLEC1 participates in recruiting Hh processing variants to the ubiquitin ligase complex.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	16	R-HSA-5387389	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	yes	reactome/R-HSA-5387389.md	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5387389: Hh processing variants are translocated to the cytosol in a VCP-dependent manner). Part of the Hh ERAD pathway in which ERLEC1 acts as cargo receptor.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	17	R-HSA-5483238	Hh processing variants are ubiquitinated	yes	reactome/R-HSA-5483238.md	Hh processing variants are ubiquitinated	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-5483238: Hh processing variants are ubiquitinated). ERLEC1 functions upstream of the ubiquitination step in ERAD, within the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	18	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866542: VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol). ERLEC1 is part of the ERAD machinery for misfolded CFTR, consistent with ERQC localization.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	19	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866546: RNF5 and RNF185 ubiquitinate misfolded CFTR). ERLEC1 operates within the ERQC as part of the CFTR ERAD pathway.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	20	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866551: CFTR binds components of the ERAD machinery for ubiquitination and degradation). ERLEC1 is one of the ERAD components that binds misfolded CFTR in the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	21	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866854: VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol). ERLEC1 participates in ERAD of the common CF-causing CFTR F508del mutation, within the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	22	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866856: RNF5 and RNF185 ubiquitinate CFTR F508del). ERLEC1 is part of the ERAD machinery for CFTR F508del within the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	23	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-8866857: CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation). ERLEC1 is an ERAD component that binds misfolded CFTR F508del.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	24	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-9931264: Active transport of ubiquitinated CD274 from ER to cytosol). ERLEC1 participates in ERAD of CD274 (PD-L1) within the ERQC.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	25	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-9931298: Ubiquitination of CD274 by ERAD complex). ERLEC1 is part of the ERAD complex that ubiquitinates CD274.
human	ERLEC1	genes/human/ERLEC1/ERLEC1-ai-review.yaml	ERLEC1	Q96DZ1	NCBITaxon:9606	Homo sapiens	26	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (R-HSA-9931313: p-S195-CD274 binds ERAD complex). ERLEC1 is part of the ERAD complex that binds phosphorylated CD274 for degradation.
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	20	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERLIN1 at the ER membrane within the CFTR ERAD machinery pathway.
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	21	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CFTR ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	22	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CFTR ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	23	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	24	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	25	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	26	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	27	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERLIN1	genes/human/ERLIN1/ERLIN1-ai-review.yaml	ERLIN1	O75477	NCBITaxon:9606	Homo sapiens	28	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN1 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	21	R-HSA-1839094	Activated FGFR1 mutants and fusions bind PLCG1	yes	reactome/R-HSA-1839094.md	Activated FGFR1 mutants and fusions bind PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling pathway annotation placing ERLIN2 at the plasma membrane. ERLIN2 is an integral ER membrane protein; plasma-membrane localization is not supported by the experimental subcellular-location data.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	22	R-HSA-1839098	Activated FGFR1 mutants and fusions phosphorylate PLCG1	yes	reactome/R-HSA-1839098.md	Activated FGFR1 mutants and fusions phosphorylate PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	23	R-HSA-1839100	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions	yes	reactome/R-HSA-1839100.md	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	24	R-HSA-5655240	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655240.md	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	25	R-HSA-5655263	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655263.md	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	26	R-HSA-5655266	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655266.md	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	27	R-HSA-5655269	Activated FGFR1 mutants bind FRS2	yes	reactome/R-HSA-5655269.md	Activated FGFR1 mutants bind FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	28	R-HSA-5655278	Activated FGFR1 mutants phosphorylate FRS2	yes	reactome/R-HSA-5655278.md	Activated FGFR1 mutants phosphorylate FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	29	R-HSA-5655290	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	30	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-signaling annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	31	R-HSA-8853322	Plasma membrane FGFR1 fusions dimerize	yes	reactome/R-HSA-8853322.md	Plasma membrane FGFR1 fusions dimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-fusion annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	32	R-HSA-8853325	Plasma membrane FGFR1 fusions autophosphorylate	yes	reactome/R-HSA-8853325.md	Plasma membrane FGFR1 fusions autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome FGFR1-fusion annotation placing ERLIN2 at the plasma membrane; inconsistent with its ER membrane localization.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	35	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERLIN2 at the ER membrane within the CFTR ERAD machinery pathway.
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	36	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CFTR ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	37	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CFTR ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	38	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	39	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	40	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CFTR F508del ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	41	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	42	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERLIN2	genes/human/ERLIN2/ERLIN2-ai-review.yaml	ERLIN2	O94905	NCBITaxon:9606	Homo sapiens	43	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERLIN2 ER membrane localization (CD274/PD-L1 ERAD pathway).
human	ERO1A	genes/human/ERO1A/ERO1A-ai-review.yaml	ERO1A	Q96HE7	NCBITaxon:9606	Homo sapiens	32	R-HSA-3341296	Reactome ER-lumen oxidative folding annotation for ERO1A	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome places ERO1A in the ER lumen; ERO1A acts on the lumenal side of the ER membrane, so this is consistent with its site of action.
human	ERO1B	genes/human/ERO1B/ERO1B-ai-review.yaml	ERO1B	Q86YB8	NCBITaxon:9606	Homo sapiens	13	R-HSA-264876	Insulin processing	no				GO:0030070	insulin processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ERO1B may drive oxidative proinsulin folding in pancreatic beta cells, contributing to insulin processing; a genuine but specialized, tissue-restricted role. Recent proteomic work corroborates ERO1B enrichment in beta cells and its association with insulin biogenesis.
human	ERO1B	genes/human/ERO1B/ERO1B-ai-review.yaml	ERO1B	Q86YB8	NCBITaxon:9606	Homo sapiens	17	R-HSA-9817575	Reactome ER-lumen oxidative folding annotation for ERO1B	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome ER-lumen localization, consistent with ERO1B's lumenal-side site of action.
human	ESPL1	genes/human/ESPL1/ESPL1-ai-review.yaml	ESPL1	Q14674	NCBITaxon:9606	Homo sapiens	23	R-HSA-2467775	Autocleavage of ESPL1 (Separase)	yes	reactome/R-HSA-2467775.md	Autocleavage of ESPL1 (Separase)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this separase reaction (autocleavage, securin sequestration or centromeric cohesin cleavage) in the cytosol.
human	ESPL1	genes/human/ESPL1/ESPL1-ai-review.yaml	ESPL1	Q14674	NCBITaxon:9606	Homo sapiens	24	R-HSA-2467798	PTTG1 (Securin) sequesters ESPL1 (Separase)	yes	reactome/R-HSA-2467798.md	PTTG1 (Securin) sequesters ESPL1 (Separase)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this separase reaction (autocleavage, securin sequestration or centromeric cohesin cleavage) in the cytosol.
human	ESPL1	genes/human/ESPL1/ESPL1-ai-review.yaml	ESPL1	Q14674	NCBITaxon:9606	Homo sapiens	25	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places this separase reaction (autocleavage, securin sequestration or centromeric cohesin cleavage) in the cytosol.
human	ESPL1	genes/human/ESPL1/ESPL1-ai-review.yaml	ESPL1	Q14674	NCBITaxon:9606	Homo sapiens	31	R-HSA-2467775	Autocleavage of ESPL1 (Separase)	yes	reactome/R-HSA-2467775.md	Autocleavage of ESPL1 (Separase)	Homo sapiens	GO:0008234	cysteine-type peptidase activity	TAS	enables	MF	false		ACCEPT	Reactome autocleavage reaction assigns cysteine-type peptidase activity to ESPL1.
human	ESPL1	genes/human/ESPL1/ESPL1-ai-review.yaml	ESPL1	Q14674	NCBITaxon:9606	Homo sapiens	37	R-HSA-2467813	Separation of Sister Chromatids	yes	reactome/R-HSA-2467813.md	Separation of Sister Chromatids	Homo sapiens	GO:0051306	mitotic sister chromatid separation	TAS	involved_in	BP	false		ACCEPT	Reactome: after APC/C destroys securin, ESPL1 cleaves centromeric RAD21, dissociating cohesin from sister centromeres and separating sister chromatids.
human	ETFA	genes/human/ETFA/ETFA-ai-review.yaml	ETFA	P13804	NCBITaxon:9606	Homo sapiens	29	R-HSA-169260	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing ETF in the mitochondrial matrix, where it accepts reducing equivalents from fatty-acyl-CoA beta-oxidation.
human	ETFA	genes/human/ETFA/ETFA-ai-review.yaml	ETFA	P13804	NCBITaxon:9606	Homo sapiens	30	R-HSA-169270	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing ETF in the mitochondrial matrix in the reaction where ETFDH re-oxidizes reduced ETF and reduces CoQ.
human	ETFB	genes/human/ETFB/ETFB-ai-review.yaml	ETFB	P38117	NCBITaxon:9606	Homo sapiens	19	R-HSA-8931858	ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement (ETFBKMT/METTL20 methylation reaction) placing ETFB in the mitochondrial matrix. Correct core location.
human	ETFB	genes/human/ETFB/ETFB-ai-review.yaml	ETFB	P38117	NCBITaxon:9606	Homo sapiens	22	R-HSA-169260	Reducing equivalents from beta-oxidation of fatty acids transfer to ETF	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (electron transfer from fatty-acid beta-oxidation to ETF) placing ETFB in the matrix compartment. Correct core location.
human	ETFB	genes/human/ETFB/ETFB-ai-review.yaml	ETFB	P38117	NCBITaxon:9606	Homo sapiens	23	R-HSA-169270	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (ETFDH re-oxidizes reduced ETF, reducing CoQ) placing ETFB in the matrix. Correct core location.
human	ETFDH	genes/human/ETFDH/ETFDH-ai-review.yaml	ETFDH	Q16134	NCBITaxon:9606	Homo sapiens	11	R-HSA-611105	Respiratory electron transport	no				GO:0022904	respiratory electron transport chain	TAS	involved_in	BP	false		ACCEPT	Reactome places ETFDH in respiratory electron transport, reducing coenzyme Q; a correct, specific process for this enzyme.
human	ETFDH	genes/human/ETFDH/ETFDH-ai-review.yaml	ETFDH	Q16134	NCBITaxon:9606	Homo sapiens	12	R-HSA-169270	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2	no				GO:0004174	electron-transferring-flavoprotein dehydrogenase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction (ETFDH oxidises reduced ETF, reduces CoQ to CoQH2) assigning the core catalytic activity. Correct.
human	ETFDH	genes/human/ETFDH/ETFDH-ai-review.yaml	ETFDH	Q16134	NCBITaxon:9606	Homo sapiens	15	R-HSA-169270	ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to CoQH2	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome asserts inner-membrane localization for the ETFDH reaction; matches experimental data.
human	ETNK1	genes/human/ETNK1/ETNK1-ai-review.yaml	ETNK1	Q9HBU6	NCBITaxon:9606	Homo sapiens	11	R-HSA-1483222	ETA is phosphorylated to PETA by CHK/ETNK	yes	reactome/R-HSA-1483222.md	ETA is phosphorylated to PETA by CHK/ETNK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the ethanolamine-phosphorylation step in the cytosol. This is the most granular correct localization for ETNK1 and is consistent with the experimental cytoplasm IDA.
human	ETNK2	genes/human/ETNK2/ETNK2-ai-review.yaml	ETNK2	Q9NVF9	NCBITaxon:9606	Homo sapiens	7	R-HSA-1483222	ETA is phosphorylated to PETA by CHK/ETNK	yes	reactome/R-HSA-1483222.md	ETA is phosphorylated to PETA by CHK/ETNK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Core cellular location. Reactome places the ETNK1/2-catalyzed phosphorylation of ethanolamine to phosphoethanolamine in the cytosol, consistent with a soluble cytosolic enzyme of the Kennedy pathway. Retain.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	11	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	FADS1 participates in alpha-linolenic acid (ALA, 18:3n-3) metabolism by performing the delta-5 desaturation step in the omega-3 pathway.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	12	R-HSA-2046105	Linoleic acid (LA) metabolism	yes	reactome/R-HSA-2046105.md	Linoleic acid (LA) metabolism	Homo sapiens	GO:0043651	linoleic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	FADS1 participates in linoleic acid (LA, 18:2n-6) metabolism by performing the delta-5 desaturation step in the omega-6 pathway.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	14	R-HSA-1989757	Expression of FADS1	yes	reactome/R-HSA-1989757.md	Expression of FADS1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization for FADS1 expression and function.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	15	R-HSA-2046089	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA	yes	reactome/R-HSA-2046089.md	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization for the omega-3 desaturation reaction.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	16	R-HSA-2046092	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA	yes	reactome/R-HSA-2046092.md	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization for the omega-6 desaturation reaction.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	20	R-HSA-2046089	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA	yes	reactome/R-HSA-2046089.md	Desaturation of eicosatetraenoyl-CoA to eicosapentaenoyl-CoA	Homo sapiens	GO:0045485	omega-6 fatty acid desaturase activity	TAS	enables	MF	false		ACCEPT	FADS1 acts on omega-6 fatty acid substrates (DGLA) to produce arachidonic acid.
human	FADS1	genes/human/FADS1/FADS1-ai-review.yaml	FADS1	O60427	NCBITaxon:9606	Homo sapiens	21	R-HSA-2046092	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA	yes	reactome/R-HSA-2046092.md	Desaturation of dihomo-gamma-lenolenoyl-CoA to arachidonoyl-CoA	Homo sapiens	GO:0045485	omega-6 fatty acid desaturase activity	TAS	enables	MF	false		ACCEPT	Duplicate annotation for omega-6 fatty acid desaturase activity from different Reactome reaction.
human	FAF2	genes/human/FAF2/FAF2-ai-review.yaml	FAF2	Q96CS3	NCBITaxon:9606	Homo sapiens	25	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation pathway annotation placing FAF2 in the extracellular region via azurophil-granule exocytosis. This derives from bulk granule proteomics and does not reflect FAF2's characterized ER/lipid-droplet membrane function.
human	FAF2	genes/human/FAF2/FAF2-ai-review.yaml	FAF2	Q96CS3	NCBITaxon:9606	Homo sapiens	26	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation annotation placing FAF2 in the azurophil granule lumen, from bulk neutrophil-granule proteomics; inconsistent with FAF2 being an integral cytoplasmic-facing ER/lipid-droplet membrane protein.
human	FAH	genes/human/FAH/FAH-ai-review.yaml	FAH	P16930	NCBITaxon:9606	Homo sapiens	14	R-HSA-71181	FAH cleaves 4FAA	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable assertion (Reactome) that FAH acts in the cytosol, where the final step of tyrosine degradation occurs.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	26	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places FANCA (in a core-complex:HSP70 assembly binding PKR) in the cytosol. This reflects a cytoplasmic/pre-assembly pool rather than the functional nuclear site.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	27	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (FA core complex assembles at ICLs) localizes FANCA to the nucleoplasm, the functional compartment of the FA pathway.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	28	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA within the FA/ICL-repair reaction set.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	29	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA within the FANCD2:FANCI monoubiquitination reaction context.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	30	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the ICL-repair reaction set.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	31	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the ICL-unhooking reaction set.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	32	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the ICL-repair reaction set.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	33	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the translesion-synthesis reaction context.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	34	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the FANCD2-deubiquitination reaction context.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	35	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the ATR/ATRIP recruitment reaction context.
human	FANCA	genes/human/FANCA/FANCA-ai-review.yaml	FANCA	O15360	NCBITaxon:9606	Homo sapiens	36	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm annotation for FANCA in the ATR-phosphorylation reaction context.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	12	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	A cytosolic pool of FANCB exists as the assembled BL100 module prior to chaperoned nuclear import (and in the FA-core-complex:HSP70 assembly implicated in PKR signaling).
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	13	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	14	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	15	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	16	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	17	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	18	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	19	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	20	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	21	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCB	genes/human/FANCB/FANCB-ai-review.yaml	FANCB	Q8NB91	NCBITaxon:9606	Homo sapiens	22	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FANCB acts in the nucleoplasm as part of the FA core complex during ICL repair.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	18	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome localizes a cytosolic FA core complex:HSP70:PKR assembly. Consistent with the documented minor cytoplasmic form of FANCC and its cytosolic PKR/HSP70 interactions.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	19	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC as the FA core complex assembles at ICLs.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	20	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	21	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC (monoubiquitination of FANCD2-FANCI step).
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	22	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	23	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	24	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	25	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	26	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC (FANCD2 deubiquitination step context).
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	27	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	28	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC within the FA ICL-repair reaction series.
human	FANCC	genes/human/FANCC/FANCC-ai-review.yaml	FANCC	Q00597	NCBITaxon:9606	Homo sapiens	29	R-HSA-6806425	TP53 stimulates FANCC expression	yes	reactome/R-HSA-6806425.md	TP53 stimulates FANCC expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location for FANCC (TP53 stimulates FANCC expression context).
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	26	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places FANCD2 in the nucleoplasm within the FANCD2-FANCI/UBE2T ICL-DNA binding step of the FA pathway.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	27	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the monoubiquitination-of-FANCD2/FANCI reaction.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	28	R-HSA-6785594	FANCD2 binds FANCI	yes	reactome/R-HSA-6785594.md	FANCD2 binds FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the FANCD2-binds-FANCI reaction.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	29	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for DNA nucleases binding the monoubiquitinated ID2 complex.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	30	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the nuclease-mediated unhooking of the ICL step.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	31	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the POLN-binds-ICL-DNA step of the FA pathway.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	32	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the POLN translesion-synthesis step.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	33	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the FANCD2 deubiquitination by USP1/WDR48 step.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	34	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the ATR/ATRIP recruitment to ICL-DNA step.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	35	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization for the ATR phosphorylation of RPA2/FANCI/FANCD2/FANCM step.
human	FANCD2	genes/human/FANCD2/FANCD2-ai-review.yaml	FANCD2	Q9BXW9	NCBITaxon:9606	Homo sapiens	36	R-HSA-6797712	CDK12 stimulates expression of DNA repair genes	yes	reactome/R-HSA-6797712.md	CDK12 stimulates expression of DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasmic localization associated with CDK12 stimulation of DNA repair gene expression (FA pathway context).
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	12	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol localization derived from a Reactome model of a cytoplasmic FA core complex:HSP70 role in PKR-mediated signaling. FANCE is predominantly nuclear; this cytosolic assignment reflects a non-canonical, peripheral role and is not a core location.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	13	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization within the FA core complex assembly at ICLs; consistent with FANCE's nuclear function.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	14	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (FANCD2:FANCI/UBE2T binding step); correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	15	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (FANCD2:FANCI monoubiquitination step); correct nuclear location.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	16	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization; correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	17	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization; correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	18	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization; correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	19	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization; correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	20	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (FANCD2 deubiquitination step); correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	21	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization; correct nuclear location for FANCE.
human	FANCE	genes/human/FANCE/FANCE-ai-review.yaml	FANCE	Q9HB96	NCBITaxon:9606	Homo sapiens	22	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization (ATR phosphorylation step); correct nuclear location for FANCE.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	14	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models a cytosolic FA-core-complex:HSP70 species that binds PKR (PKR-mediated signaling). FANCF is predominantly nuclear, so a cytosolic pool is peripheral and less well established.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	15	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction (FA core complex assembles at ICLs) placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	16	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	17	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	18	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	19	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	20	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	21	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	22	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	23	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCF	genes/human/FANCF/FANCF-ai-review.yaml	FANCF	Q9NPI8	NCBITaxon:9606	Homo sapiens	24	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ICL-repair reaction placing FANCF in the nucleoplasm.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	29	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places a FA core complex:HSP70 species (binding PKR) in the cytosol; corresponds to the minor cytoplasmic pool of FANCG rather than its core nuclear function.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	30	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome localizes FANCG to the nucleoplasm as part of FA-pathway ICL-repair reactions; a correct core location for the nuclear FA complex.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	31	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	32	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization (Monoubiquitination of FANCD2:FANCI reaction); correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	33	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	34	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	35	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	36	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	37	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization (FANCD2 deubiquitination by USP1:WDR48); correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	38	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCG	genes/human/FANCG/FANCG-ai-review.yaml	FANCG	O15287	NCBITaxon:9606	Homo sapiens	39	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization within the FA ICL-repair pathway; correct core location.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	17	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for the FA/ICL repair reaction (Monoubiquitination of FANCD2:FANCI). Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	18	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for the ID/nuclease binding step. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	19	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for the ICL unhooking step. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	20	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for the POLN-ICL binding step. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	21	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for translesion synthesis across the unhooked ICL. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	22	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for FANCD2 deubiquitination by USP1:WDR48. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	23	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for ATR phosphorylation of RPA2, FANCI, FANCD2, FANCM at ICL-DNA. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	26	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for FANCD2:FANCI + UBE2T binding ICL-DNA. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	27	R-HSA-6785594	FANCD2 binds FANCI	yes	reactome/R-HSA-6785594.md	FANCD2 binds FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for the FANCD2 binds FANCI step. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	28	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for recruitment of ATR:ATRIP to ICL-DNA. Correct.
human	FANCI	genes/human/FANCI/FANCI-ai-review.yaml	FANCI	Q9NVI1	NCBITaxon:9606	Homo sapiens	29	R-HSA-6797712	CDK12 stimulates expression of DNA repair genes	yes	reactome/R-HSA-6797712.md	CDK12 stimulates expression of DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm localization for CDK12 stimulation of DNA-repair gene expression. Location correct for FANCI.
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	25	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-traceable cytosolic localization (from a PKR-signaling reaction involving an FA core complex:HSP70 assembly). FANCL's core E3 function is nuclear/chromatin.
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	27	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (FA core complex assembly at ICLs).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	28	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (FANCD2:FANCI and UBE2T binding ICL-DNA with the FA core complex).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	29	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (monoubiquitination of FANCD2:FANCI).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	30	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (DNA nucleases bind monoubiquitinated ID2 complex).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	31	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (DNA nucleases unhook the ICL).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	32	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (POLN binds ICL-DNA).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	33	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (translesion synthesis across unhooked ICL by POLN).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	34	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (FANCD2 deubiquitination by USP1:WDR48).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	35	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (ATR:ATRIP recruited to ICL-DNA).
human	FANCL	genes/human/FANCL/FANCL-ai-review.yaml	FANCL	Q9NW38	NCBITaxon:9606	Homo sapiens	36	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-traceable nucleoplasmic localization (ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA).
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	35	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Cytosol localization derives from a Reactome PKR-signaling reaction (FA core complex:HSP70s binds PKR). FANCM is overwhelmingly nuclear and chromatin-restricted; a cytosolic pool is not a characteristic localization for its DNA-repair function.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	36	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions; consistent with FANCM's nuclear residence.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	37	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	38	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	39	R-HSA-6786166	Translesion synthesis across unhooked ICL by POLN	yes	reactome/R-HSA-6786166.md	Translesion synthesis across unhooked ICL by POLN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	40	R-HSA-6786171	FANCD2 deubiquitination by USP1:WDR48	yes	reactome/R-HSA-6786171.md	FANCD2 deubiquitination by USP1:WDR48	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	41	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions (ATR phosphorylation of FA proteins).
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	42	R-HSA-6785087	FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA	yes	reactome/R-HSA-6785087.md	FANCM:FAAP24 and APITD1:STRA13 bind ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions (FANCM:FAAP24 binds ICL-DNA).
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	43	R-HSA-6785126	FA core complex assembles at DNA interstrand crosslinks (ICLs)	yes	reactome/R-HSA-6785126.md	FA core complex assembles at DNA interstrand crosslinks (ICLs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions (FA core complex assembly at ICLs).
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	44	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	45	R-HSA-6785607	FANCM binds FAAP24	yes	reactome/R-HSA-6785607.md	FANCM binds FAAP24	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions (FANCM binds FAAP24).
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	46	R-HSA-6786155	POLN binds ICL-DNA	yes	reactome/R-HSA-6786155.md	POLN binds ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions.
human	FANCM	genes/human/FANCM/FANCM-ai-review.yaml	FANCM	Q8IYD8	NCBITaxon:9606	Homo sapiens	47	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome FA pathway reactions (ATR:ATRIP recruitment to ICL-DNA).
human	FAR1	genes/human/FAR1/FAR1-ai-review.yaml	FAR1	Q8WVX9	NCBITaxon:9606	Homo sapiens	13	R-HSA-9640463	Wax biosynthesis	yes	reactome/R-HSA-9640463.md	Wax biosynthesis	Homo sapiens	GO:0010025	wax biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Same wax biosynthetic role, asserted by Reactome. Valid downstream use of the fatty-alcohol product; keep as non-core (the principal human role is ether-lipid/plasmalogen biosynthesis).
human	FAR1	genes/human/FAR1/FAR1-ai-review.yaml	FAR1	Q8WVX9	NCBITaxon:9606	Homo sapiens	18	R-HSA-390425	FAR1 reduces PalmCoA to HXOL	yes	reactome/R-HSA-390425.md	FAR1 reduces PalmCoA to HXOL	Homo sapiens	GO:0016491	oxidoreductase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	FAR1 is an oxidoreductase; this Reactome-asserted parent term is correct but very generic. The specific molecular function (GO:0102965) is preferred; keep this general term as non-core.
human	FAR1	genes/human/FAR1/FAR1-ai-review.yaml	FAR1	Q8WVX9	NCBITaxon:9606	Homo sapiens	19	R-HSA-390425	FAR1 reduces PalmCoA to HXOL	yes	reactome/R-HSA-390425.md	FAR1 reduces PalmCoA to HXOL	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Peroxisomal membrane localization asserted by Reactome; correct and consistent with the experimental topology data. Core cellular component.
human	FAR2	genes/human/FAR2/FAR2-ai-review.yaml	FAR2	Q96K12	NCBITaxon:9606	Homo sapiens	9	R-HSA-9640463	Wax biosynthesis	yes	reactome/R-HSA-9640463.md	Wax biosynthesis	Homo sapiens	GO:0010025	wax biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation placing FAR2 in wax biosynthesis, where it reduces fatty acids to fatty alcohols in the peroxisome for downstream wax ester formation. Correct core process.
human	FAR2	genes/human/FAR2/FAR2-ai-review.yaml	FAR2	Q96K12	NCBITaxon:9606	Homo sapiens	10	R-HSA-390438	FAR2 reduces PalmCoA to HXOL	yes	reactome/R-HSA-390438.md	FAR2 reduces PalmCoA to HXOL	Homo sapiens	GO:0016491	oxidoreductase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Correct but overly general. FAR2 is an oxidoreductase, but the specific alcohol-forming fatty acyl-CoA reductase terms (GO:0080019, GO:0102965) capture its function precisely. Flagged as over-annotation, not removed.
human	FAR2	genes/human/FAR2/FAR2-ai-review.yaml	FAR2	Q96K12	NCBITaxon:9606	Homo sapiens	11	R-HSA-390438	FAR2 reduces PalmCoA to HXOL	yes	reactome/R-HSA-390438.md	FAR2 reduces PalmCoA to HXOL	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation of peroxisomal membrane localization, consistent with the experimental IDA and UniProt curation. Correct core localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	66	R-HSA-139952	Caspase-8 processing in the DISC	yes	reactome/R-HSA-139952.md	Caspase-8 processing in the DISC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	67	R-HSA-141310	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10	yes	reactome/R-HSA-141310.md	FASL:FAS Receptor Trimer:FADD complex binds procaspase-10	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	68	R-HSA-3465429	FLIP(S) and procaspase-8 form heterodimer	yes	reactome/R-HSA-3465429.md	FLIP(S) and procaspase-8 form heterodimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	69	R-HSA-3465448	Caspase-8 and FLIP(L) processing at DISC	yes	reactome/R-HSA-3465448.md	Caspase-8 and FLIP(L) processing at DISC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	70	R-HSA-3465459	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling	yes	reactome/R-HSA-3465459.md	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	71	R-HSA-5675456	FLIP(L) and procaspase-8 form heterodimer	yes	reactome/R-HSA-5675456.md	FLIP(L) and procaspase-8 form heterodimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	72	R-HSA-6800001	TP53 family members stimulate FAS gene expression	yes	reactome/R-HSA-6800001.md	TP53 family members stimulate FAS gene expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	73	R-HSA-71050	Trimerization of the FASL:FAS receptor complex	yes	reactome/R-HSA-71050.md	Trimerization of the FASL:FAS receptor complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	74	R-HSA-73945	FAS-mediated dimerization of procaspase-8	yes	reactome/R-HSA-73945.md	FAS-mediated dimerization of procaspase-8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	75	R-HSA-75244	FASL binds FAS Receptor	yes	reactome/R-HSA-75244.md	FASL binds FAS Receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	76	R-HSA-83586	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8	yes	reactome/R-HSA-83586.md	FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FAS	genes/human/FAS/FAS-ai-review.yaml	FAS	P25445	NCBITaxon:9606	Homo sapiens	77	R-HSA-83650	FasL:Fas binds FADD	yes	reactome/R-HSA-83650.md	FasL:Fas binds FADD	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	ISOFORM-SPECIFIC. TAS from Reactome for plasma membrane localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	32	R-HSA-75105	Fatty acyl-CoA biosynthesis	yes	reactome/R-HSA-75105.md	Fatty acyl-CoA biosynthesis	Homo sapiens	GO:0046949	fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome pathway (""Fatty acyl-CoA biosynthesis"") placing FASN in fatty acid/acyl-CoA biosynthesis. FASN produces free palmitate (released by its thioesterase), which is subsequently activated to acyl-CoA by other enzymes; the term is pathway-context accurate. Kept non-core (the direct product term is fatty acid biosynthetic process)."
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	53	R-HSA-163733	Transcriptional activation of FASN monomer gene by ChREBP:MLX	yes	reactome/R-HSA-163733.md	Transcriptional activation of FASN monomer gene by ChREBP:MLX	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	54	R-HSA-163756	Formation of fatty acid synthase (FAS) dimer	yes	reactome/R-HSA-163756.md	Formation of fatty acid synthase (FAS) dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (FAS dimer formation) placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	55	R-HSA-199202	Phosphopantetheine conjugation of the ACP domain of FAS	yes	reactome/R-HSA-199202.md	Phosphopantetheine conjugation of the ACP domain of FAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (phosphopantetheine conjugation of the ACP domain) placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	56	R-HSA-75872	Conversion of malonyl-CoA and acetyl-CoA to palmitate	yes	reactome/R-HSA-75872.md	Conversion of malonyl-CoA and acetyl-CoA to palmitate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (conversion of malonyl-CoA and acetyl-CoA to palmitate) placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	57	R-HSA-9948053	NS3 binds FASN dimer	yes	reactome/R-HSA-9948053.md	NS3 binds FASN dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	58	R-HSA-1655843	Expression of Fatty Acid Synthase (FASN)	yes	reactome/R-HSA-1655843.md	Expression of Fatty Acid Synthase (FASN)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (expression of FASN) placing FASN in the cytosol. Correct core localization.
human	FASN	genes/human/FASN/FASN-ai-review.yaml	FASN	P49327	NCBITaxon:9606	Homo sapiens	59	R-HSA-9605063	Expression of FASN regulated by NR1H2 or NR1H3	yes	reactome/R-HSA-9605063.md	Expression of FASN regulated by NR1H2 or NR1H3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing FASN in the cytosol. Correct core localization.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	13	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization within generic CRL1/NEDD8-cycle reactions. Plausible localization, though derived from pathway context.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	14	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CRL1 NEDD8-binding reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	15	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CAND1/CRL reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	16	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COMMD/CAND1/CRL reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	17	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COP9-signalosome deneddylation reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	18	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic DCUN1D3/CRL1 reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	19	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E2-to-substrate ubiquitin-transfer reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	20	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-release reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	21	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic substrate-polyubiquitination reaction.
human	FBXL12	genes/human/FBXL12/FBXL12-ai-review.yaml	FBXL12	Q9NXK8	NCBITaxon:9606	Homo sapiens	22	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-substrate-E2 interaction reaction.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation propagated across the generic CRL1/neddylation reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 neddylation reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (CAND1) reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (COMMD/CAND1) reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL deneddylation (COP9) reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 (DCUN1D3) reaction set.
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (transfer of Ub from E2 to substrate).
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (release of E3 from substrate).
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (polyubiquitination of substrate).
human	FBXL13	genes/human/FBXL13/FBXL13-ai-review.yaml	FBXL13	Q8NEE6	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (interaction of E3 with substrate and E2-Ub).
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	10	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within generic CRL1/NEDD8-cycle reactions.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	11	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CRL1 NEDD8-binding reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	12	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CAND1/CRL reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	13	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COMMD/CAND1/CRL reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	14	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COP9-signalosome deneddylation reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	15	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic DCUN1D3/CRL1 reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	16	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E2-to-substrate ubiquitin-transfer reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	17	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-release reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	18	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic substrate-polyubiquitination reaction.
human	FBXL14	genes/human/FBXL14/FBXL14-ai-review.yaml	FBXL14	Q8N1E6	NCBITaxon:9606	Homo sapiens	19	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-substrate-E2 interaction reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within generic CRL1/NEDD8-cycle reactions.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CRL1 NEDD8-binding reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CAND1/CRL reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COMMD/CAND1/CRL reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COP9-signalosome deneddylation reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic DCUN1D3/CRL1 reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E2-to-substrate ubiquitin-transfer reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-release reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic substrate-polyubiquitination reaction.
human	FBXL15	genes/human/FBXL15/FBXL15-ai-review.yaml	FBXL15	Q9H469	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-substrate-E2 interaction reaction.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	4	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation propagated across the generic CRL1/neddylation reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	5	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 neddylation reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	6	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (CAND1) reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	7	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (COMMD/CAND1) reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	8	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL deneddylation (COP9) reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	9	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 (DCUN1D3) reaction set.
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	10	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (transfer of Ub from E2 to substrate).
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	11	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (release of E3 from substrate).
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	12	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (polyubiquitination of substrate).
human	FBXL16	genes/human/FBXL16/FBXL16-ai-review.yaml	FBXL16	Q8N461	NCBITaxon:9606	Homo sapiens	13	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (interaction of E3 with substrate and E2-Ub).
human	FBXL17	genes/human/FBXL17/FBXL17-ai-review.yaml	FBXL17	Q9UF56	NCBITaxon:9606	Homo sapiens	11	R-HSA-9708517	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	yes	reactome/R-HSA-9708517.md	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXL17 nucleoplasmic localization within a BACH1 ubiquitination reaction. Consistent with nuclear action.
human	FBXL17	genes/human/FBXL17/FBXL17-ai-review.yaml	FBXL17	Q9UF56	NCBITaxon:9606	Homo sapiens	12	R-HSA-9708525	BACH1:FBXL17 binds SCF(SKP2) complex	yes	reactome/R-HSA-9708525.md	BACH1:FBXL17 binds SCF(SKP2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXL17 nucleoplasmic localization (BACH1:FBXL17 binds SCF). Consistent with nuclear action.
human	FBXL17	genes/human/FBXL17/FBXL17-ai-review.yaml	FBXL17	Q9UF56	NCBITaxon:9606	Homo sapiens	13	R-HSA-9708557	FBXL17 binds BACH1:MAFK	yes	reactome/R-HSA-9708557.md	FBXL17 binds BACH1:MAFK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXL17 nucleoplasmic localization (FBXL17 binds BACH1:MAFK). Consistent with nuclear action.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	4	R-HSA-8854051	SCF-FBXL18 ubiquitinates FBXL7	yes	reactome/R-HSA-8854051.md	SCF-FBXL18 ubiquitinates FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome cytosol annotation tied to the curated reaction ""SCF-FBXL18 ubiquitinates FBXL7"", which reflects FBXL18's actual ligase reaction. The cytosol is a plausible compartment for this SCF activity."
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	5	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1/neddylation reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	6	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 neddylation reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	7	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (CAND1) reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	8	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (COMMD/CAND1) reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	9	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL deneddylation (COP9) reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	10	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 (DCUN1D3) reaction set.
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	11	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (transfer of Ub from E2 to substrate).
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	12	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (release of E3 from substrate).
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	13	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (polyubiquitination of substrate).
human	FBXL18	genes/human/FBXL18/FBXL18-ai-review.yaml	FBXL18	Q96ME1	NCBITaxon:9606	Homo sapiens	14	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (interaction of E3 with substrate and E2-Ub).
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	14	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within generic CRL1/NEDD8-cycle reactions.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	15	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CRL1 NEDD8-binding reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	16	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic CAND1/CRL reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	17	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COMMD/CAND1/CRL reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	18	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic COP9-signalosome deneddylation reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	19	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic DCUN1D3/CRL1 reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	20	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E2-to-substrate ubiquitin-transfer reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	21	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-release reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	22	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic substrate-polyubiquitination reaction.
human	FBXL20	genes/human/FBXL20/FBXL20-ai-review.yaml	FBXL20	Q96IG2	NCBITaxon:9606	Homo sapiens	23	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization within a generic E3-substrate-E2 interaction reaction.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	7	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation propagated across the generic CRL1/neddylation reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 neddylation reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	9	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (CAND1) reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (COMMD/CAND1) reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	11	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL deneddylation (COP9) reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 (DCUN1D3) reaction set.
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	13	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (transfer of Ub from E2 to substrate).
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	14	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (release of E3 from substrate).
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	15	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (polyubiquitination of substrate).
human	FBXL22	genes/human/FBXL22/FBXL22-ai-review.yaml	FBXL22	Q6P050	NCBITaxon:9606	Homo sapiens	16	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (interaction of E3 with substrate and E2-Ub).
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	21	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (neddylation of CRL1). Generic CRL-pathway localization; secondary to the nuclear pool.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	22	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (NEDD8:UBE2M binds CRL1). Generic CRL-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	23	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (CAND1 binds cytosolic CRL). Generic CRL-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	24	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COMMDs displace CAND1). Generic CRL-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	25	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COP9 signalosome deneddylates CRL). Generic CRL-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	26	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (DCUN1D3 binds CRL1). Generic CRL-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	27	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate). Generic ubiquitination-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	28	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Generic ubiquitination-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	29	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (polyubiquitination of substrate). Generic ubiquitination-pathway localization.
human	FBXL3	genes/human/FBXL3/FBXL3-ai-review.yaml	FBXL3	Q9UKT7	NCBITaxon:9606	Homo sapiens	30	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub). Generic ubiquitination-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	20	R-HSA-5691108	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	yes	reactome/R-HSA-5691108.md	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (SKP1:FBXL5:CUL1:NEDD8 ubiquitinates IREB2). Consistent with the core cytoplasmic site of action.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	21	R-HSA-5691167	CUL1, SKP1, FBXL5 bind	yes	reactome/R-HSA-5691167.md	CUL1, SKP1, FBXL5 bind	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CUL1, SKP1, FBXL5 bind). Consistent with the core cytoplasmic site of action.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	22	R-HSA-5691176	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	yes	reactome/R-HSA-5691176.md	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (NEDD8 binds CUL1 in SKP1:CUL1:FBXL5). Consistent with the core cytoplasmic site of action.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	23	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (neddylation of CRL1). Generic CRL-pathway localization, consistent with the cytoplasmic site of action.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	24	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (NEDD8:UBE2M binds CRL1). Generic CRL-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	25	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (CAND1 binds cytosolic CRL). Generic CRL-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	26	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COMMDs displace CAND1). Generic CRL-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	27	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COP9 signalosome deneddylates CRL). Generic CRL-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	28	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (DCUN1D3 binds CRL1). Generic CRL-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	29	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate). Generic ubiquitination-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	30	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Generic ubiquitination-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	31	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (polyubiquitination of substrate). Generic ubiquitination-pathway localization.
human	FBXL5	genes/human/FBXL5/FBXL5-ai-review.yaml	FBXL5	Q9UKA1	NCBITaxon:9606	Homo sapiens	32	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub). Generic ubiquitination-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	19	R-HSA-8854051	SCF-FBXL18 ubiquitinates FBXL7	yes	reactome/R-HSA-8854051.md	SCF-FBXL18 ubiquitinates FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (SCF-FBXL18 ubiquitinates FBXL7). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	20	R-HSA-8854071	Proteasome-mediated degradation of PolyUb-FBXL7	yes	reactome/R-HSA-8854071.md	Proteasome-mediated degradation of PolyUb-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (proteasome-mediated degradation of PolyUb-FBXL7). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	21	R-HSA-8853496	SCF:FBXL7 binds AURKA	yes	reactome/R-HSA-8853496.md	SCF:FBXL7 binds AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (SCF:FBXL7 binds AURKA). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	22	R-HSA-8854041	SCF-FBXL7 ubiquitinates AURKA	yes	reactome/R-HSA-8854041.md	SCF-FBXL7 ubiquitinates AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (SCF-FBXL7 ubiquitinates AURKA). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	23	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (proteasome degrades AURKA ubiquitinated by SCF-FBXL7). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	24	R-HSA-8854052	Formation of the SCF-FBXL7 complex	yes	reactome/R-HSA-8854052.md	Formation of the SCF-FBXL7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (formation of the SCF-FBXL7 complex). Consistent with the cytoplasmic site of action.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	25	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (neddylation of CRL1). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	26	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (NEDD8:UBE2M binds CRL1). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	27	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (CAND1 binds cytosolic CRL). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	28	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COMMDs displace CAND1). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	29	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COP9 signalosome deneddylates CRL). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	30	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (DCUN1D3 binds CRL1). Generic CRL-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	31	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate). Generic ubiquitination-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	32	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Generic ubiquitination-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	33	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (polyubiquitination of substrate). Generic ubiquitination-pathway localization.
human	FBXL7	genes/human/FBXL7/FBXL7-ai-review.yaml	FBXL7	Q9UJT9	NCBITaxon:9606	Homo sapiens	34	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub). Generic ubiquitination-pathway localization.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation, propagated across the generic CRL1/neddylation reaction set. The cytosol is a plausible compartment for an SCF substrate receptor.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	10	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 neddylation reaction set.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (CAND1) reaction set.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	12	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL (COMMD/CAND1) reaction set.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL deneddylation (COP9) reaction set.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	14	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic CRL1 (DCUN1D3) reaction set.
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	15	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (transfer of Ub from E2 to substrate).
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	16	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (release of E3 from substrate).
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	17	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (polyubiquitination of substrate).
human	FBXL8	genes/human/FBXL8/FBXL8-ai-review.yaml	FBXL8	Q96CD0	NCBITaxon:9606	Homo sapiens	18	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol annotation from the generic ubiquitination reaction set (interaction of E3 with substrate and E2-Ub).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FBXO10/the CRL1 complex in the cytosol, a generic localization derived from neddylation/CRL-cycle reactions.
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FBXO10/the CRL1 complex in the cytosol (NEDD8 conjugation reaction).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the cytosolic CRL E3 ligase (with FBXO10) in the cytosol (CAND1 binding reaction).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the cytosolic CRL E3 ligase (with FBXO10) in the cytosol (COMMD/CAND1 reaction).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the cytosolic CRL E3 ligase (with FBXO10) in the cytosol (COP9 signalosome deneddylation).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the CRL1 complex (with FBXO10) in the cytosol (DCUN1D3 binding).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the E3-substrate complex (with FBXO10) in the cytosol (transfer of Ub to substrate).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the E3-substrate complex (with FBXO10) in the cytosol (release of E3 from polyubiquitinated substrate).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the E3-substrate complex (with FBXO10) in the cytosol (polyubiquitination of substrate).
human	FBXO10	genes/human/FBXO10/FBXO10-ai-review.yaml	FBXO10	Q9UK96	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the E3-substrate complex (with FBXO10) in the cytosol (interaction of E3 with substrate and E2-Ub).
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	6	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization within the neddylation/CRL pathway reactions. A plausible but generic localization not tied to a specific demonstrated FBXO15 function.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	7	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (NEDD8:UBE2M binds CRL1) propagated to all CRL1 F-box subunits. Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	8	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (CAND1 binds cytosolic CRL E3 ligases) propagated to CRL components. Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	9	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (COMMDs displace CAND1 from cytosolic CRLs). Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	10	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (COP9 signalosome deneddylates cytosolic CRLs). Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	11	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (MyrG-DCUN1D3 binds CRL1) propagated to CRL1 subunits. Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	12	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (transfer of Ub from E2 to substrate) within the general ubiquitination machinery. Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	13	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (release of E3 from polyubiquitinated substrate). Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	14	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (polyubiquitination of substrate). Generic, non-specific.
human	FBXO15	genes/human/FBXO15/FBXO15-ai-review.yaml	FBXO15	Q8NCQ5	NCBITaxon:9606	Homo sapiens	15	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome generic cytosol localization (interaction of E3 with substrate and E2-Ub complex). Generic, non-specific.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	17	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within the CRL1/SCF neddylation pathway. Consistent with cytoplasmic SCF assembly.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	18	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CRL1 neddylation reaction). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	19	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CAND1 binding to cytosolic CRL ligases). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	20	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COMMD displacement of CAND1 from cytosolic CRL ligases). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	21	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COP9 signalosome deneddylation of cytosolic CRL ligases). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	22	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (DCUN1D3 binding to CRL1). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	23	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate, antigen processing/proteasome pathway). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	24	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	25	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (polyubiquitination of substrate). Redundant cytosol annotation.
human	FBXO17	genes/human/FBXO17/FBXO17-ai-review.yaml	FBXO17	Q96EF6	NCBITaxon:9606	Homo sapiens	26	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub complex). Redundant cytosol annotation.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	26	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome neddylation-pathway annotation of cytosolic localization for the CRL1/SCF context. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	27	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL1/neddylation cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	28	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (CAND1 binds cytosolic CRL) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	29	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (COMMD/CAND1) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	30	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (COP9 signalosome deneddylation) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	31	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (DCUN1D3 binds CRL1) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	32	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (Transfer of Ub from E2 to substrate) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	33	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (Release of E3 from polyubiquitinated substrate) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	34	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (Polyubiquitination of substrate) cytosolic localization annotation. Correct compartment.
human	FBXO2	genes/human/FBXO2/FBXO2-ai-review.yaml	FBXO2	Q9UK22	NCBITaxon:9606	Homo sapiens	35	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (Interaction of E3 with substrate and E2-Ub) cytosolic localization annotation. Correct compartment.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol assigned via a generic CRL1 (cullin-RING ligase) neddylation/cycle reaction. Correct compartment but generic and inherited from pathway context.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic CRL1 neddylation/cycle reaction.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic cytosolic CRL E3 ligase (CAND1-binding) reaction.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic cytosolic CRL E3 ligase (COMMD/CAND1) reaction.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from the COP9-signalosome deneddylation reaction on cytosolic CRL complexes.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic CRL1 (DCUN1D3-binding) reaction.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic ubiquitin-transfer (E2-to-substrate) reaction in the antigen-processing/proteasome pathway.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic reaction (release of E3 from polyubiquitinated substrate).
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic polyubiquitination-of-substrate reaction.
human	FBXO21	genes/human/FBXO21/FBXO21-ai-review.yaml	FBXO21	O94952	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS localization to cytosol from a generic reaction (interaction of E3 with substrate and E2-Ub complex).
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	19	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization within a generic CRL1 neddylation reaction (AcM-UBE2M transfers NEDD8 to CRL1). Generic compartment annotation propagated to all CRL1 members.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	20	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic CRL1 neddylation reaction (NEDD8:AcM-UBE2M binds CRL1). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	21	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic CRL reaction (CAND1 binds cytosolic CRL E3 ligases). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	22	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic CRL reaction (COMMDs displace CAND1 from cytosolic CRL complexes). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	23	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic CRL reaction (COP9 signalosome deneddylates cytosolic CRL complexes). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	24	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic CRL1 reaction (MyrG-DCUN1D3 binds CRL1). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	25	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic ubiquitination reaction (transfer of Ub from E2 to substrate). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	26	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic ubiquitination reaction (release of E3 from polyubiquitinated substrate). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	27	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic ubiquitination reaction (polyubiquitination of substrate). Generic compartment annotation.
human	FBXO22	genes/human/FBXO22/FBXO22-ai-review.yaml	FBXO22	Q8NEZ5	NCBITaxon:9606	Homo sapiens	28	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization within a generic ubiquitination reaction (interaction of E3 with substrate and E2-Ub complex). Generic compartment annotation.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	11	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL/SCF neddylation reactions (AcM-UBE2M transfers NEDD8 to CRL1). FBXO27 acts as a cytosolic SCF substrate receptor.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	12	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL1/SCF neddylation reaction (NEDD8:AcM-UBE2M binds CRL1). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	13	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL regulation reaction (CAND1 binds cytosolic CRL E3 ligases). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	14	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL regulation reaction (COMMDs displace CAND1 from cytosolic CRL complexes). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	15	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL regulation reaction (COP9 signalosome deneddylates cytosolic CRL complexes). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	16	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL1 neddylation reaction (MyrG-DCUN1D3 binds CRL1). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	17	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (transfer of Ub from E2 to substrate). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	18	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (release of E3 from polyubiquitinated substrate). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	19	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (polyubiquitination of substrate). Consistent with FBXO27's cytosolic SCF context.
human	FBXO27	genes/human/FBXO27/FBXO27-ai-review.yaml	FBXO27	Q8NI29	NCBITaxon:9606	Homo sapiens	20	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (interaction of E3 with substrate and E2-Ub complex). Consistent with FBXO27's cytosolic SCF context.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL1/ neddylation pathway reaction (AcM-UBE2M transfers NEDD8 to CRL1). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL1/ neddylation pathway reaction (NEDD8:AcM-UBE2M binds CRL1). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL cycle reaction (CAND1 binds cytosolic CRL E3 ligases). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL cycle reaction (COMMDs displace CAND1 from cytosolic CRL complexes). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL cycle reaction (COP9 signalosome deneddylates cytosolic CRL complexes). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic CRL1 reaction (MyrG-DCUN1D3 binds CRL1 complex). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic ubiquitination reaction (transfer of Ub from E2 to substrate). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic ubiquitination reaction (release of E3 from polyubiquitinated substrate). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic ubiquitination reaction (polyubiquitination of substrate). Plausible but generic pathway-context localization.
human	FBXO30	genes/human/FBXO30/FBXO30-ai-review.yaml	FBXO30	Q8TB52	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization derived from a generic ubiquitination reaction (interaction of E3 with substrate and E2-Ub complex). Plausible but generic pathway-context localization.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization derived from generic CRL1/neddylation pathway reactions in which the SCF complex participates. Consistent with cytoplasmic localization but pathway-context, not FBXO40-specific evidence.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic CRL1/NEDD8 pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic CAND1/CRL pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic COMMD/CAND1/CRL pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic COP9-signalosome deneddylation pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic DCUN1D3/CRL1 pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic ubiquitin-transfer pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic ubiquitin-transfer pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic polyubiquitination pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO40	genes/human/FBXO40/FBXO40-ai-review.yaml	FBXO40	Q9UH90	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol localization from a generic E3-substrate-E2 interaction pathway reaction. Redundant with the other Reactome cytosol annotations.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization assigned within generic Cullin-RING ligase (CRL1/neddylation) reactions. Plausible compartment for an SCF adaptor, but reflects pathway curation of the CRL machinery rather than FBXO41-specific experimental localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization assigned within generic CRL1/neddylation reactions. Duplicate of the cytosol annotation from a related Reactome reaction.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from the CAND1-binds-CRL reaction. Reflects generic CRL machinery curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	11	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from the COMMD-displaces-CAND1 reaction. Reflects generic CRL machinery curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from the COP9-signalosome-deneddylates-CRL reaction. Reflects generic CRL machinery curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	13	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from the DCUN1D3-binds-CRL1 reaction. Reflects generic CRL machinery curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	14	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from a generic ubiquitination reaction (transfer of Ub from E2 to substrate). Reflects generic ubiquitin-pathway curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	15	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from a generic ubiquitination reaction (release of E3 from polyubiquitinated substrate). Reflects generic ubiquitin-pathway curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	16	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from a generic ubiquitination reaction (polyubiquitination of substrate). Reflects generic ubiquitin-pathway curation, not FBXO41-specific localization.
human	FBXO41	genes/human/FBXO41/FBXO41-ai-review.yaml	FBXO41	Q8TF61	NCBITaxon:9606	Homo sapiens	17	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization from a generic ubiquitination reaction (interaction of E3 with substrate and E2-Ub complex). Reflects generic ubiquitin-pathway curation, not FBXO41-specific localization.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	51	R-HSA-163010	Down Regulation of Emi1 through Phosphorylation of Emi1	yes	reactome/R-HSA-163010.md	Down Regulation of Emi1 through Phosphorylation of Emi1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation placing EMI1 in the nucleoplasm within cell-cycle reactions.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	52	R-HSA-174097	Association of Emi1 with Cdh1	yes	reactome/R-HSA-174097.md	Association of Emi1 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation (Association of Emi1 with Cdh1) placing EMI1 in the nucleoplasm.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	53	R-HSA-174122	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	yes	reactome/R-HSA-174122.md	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation (phosphorylation of Emi1 DSGxxS degron) placing EMI1 in the nucleoplasm.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	54	R-HSA-174174	Phosphorylation of the Emi1 DSGxxS degron by Plk1	yes	reactome/R-HSA-174174.md	Phosphorylation of the Emi1 DSGxxS degron by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation (Plk1 phosphorylation of Emi1) placing EMI1 in the nucleoplasm.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	55	R-HSA-174235	Association of Emi1 with Cdc20	yes	reactome/R-HSA-174235.md	Association of Emi1 with Cdc20	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation (Association of Emi1 with Cdc20) placing EMI1 in the nucleoplasm.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	56	R-HSA-8961699	FBXO5 gene expression is stimulated by E2F1	yes	reactome/R-HSA-8961699.md	FBXO5 gene expression is stimulated by E2F1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation (FBXO5 gene expression stimulated by E2F1) placing EMI1 in the nucleoplasm.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	57	R-HSA-174159	Ubiquitination of Emi1 by SCF-beta-TrCP	yes	reactome/R-HSA-174159.md	Ubiquitination of Emi1 by SCF-beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation (Ubiquitination of Emi1 by SCF-beta-TrCP) placing EMI1 in the cytosol.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	58	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation (SCF-mediated degradation of Emi1) placing EMI1 in the cytosol.
human	FBXO5	genes/human/FBXO5/FBXO5-ai-review.yaml	FBXO5	Q9UKT4	NCBITaxon:9606	Homo sapiens	59	R-HSA-174209	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	yes	reactome/R-HSA-174209.md	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation (phosphorylated Emi1 binds beta-TrCP) placing EMI1 in the cytosol.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	26	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL1/neddylation reaction (NEDD8 transfer to CRL1). Consistent with the cytoplasmic localization of FBXO6 and its SCF complex.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	27	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a CRL1/neddylation reaction. Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	28	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CAND1 binds cytosolic CRL E3 ligases). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	29	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COMMDs displace CAND1 from cytosolic CRL complexes). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	30	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COP9 signalosome deneddylates cytosolic CRL complexes). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	31	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (MyrG-DCUN1D3 binds CRL1 complex). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	32	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (transfer of Ub from E2 to substrate). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	33	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (release of E3 from polyubiquitinated substrate). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	34	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (polyubiquitination of substrate). Consistent with FBXO6's cytoplasmic localization.
human	FBXO6	genes/human/FBXO6/FBXO6-ai-review.yaml	FBXO6	Q9NRD1	NCBITaxon:9606	Homo sapiens	35	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within a generic ubiquitination reaction (interaction of E3 with substrate and E2-Ub complex). Consistent with FBXO6's cytoplasmic localization.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	69	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome neddylation/CRL-machinery pathway annotation placing FBXO7 in the cytosol. The cytosol is the predominant FBXO7 compartment.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	70	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL-machinery pathway annotation placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	71	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL-machinery pathway annotation (CAND1 binding) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	72	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL-machinery pathway annotation (COMMD/CAND1) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	73	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL-machinery pathway annotation (COP9 signalosome deneddylation) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	74	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome CRL-machinery pathway annotation (DCUN1D3) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	75	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome ubiquitination-pathway annotation (Ub transfer from E2 to substrate) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	76	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome ubiquitination-pathway annotation (release of E3 from polyubiquitinated substrate) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	77	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome ubiquitination-pathway annotation (polyubiquitination of substrate) placing FBXO7 in the cytosol.
human	FBXO7	genes/human/FBXO7/FBXO7-ai-review.yaml	FBXO7	Q9Y3I1	NCBITaxon:9606	Homo sapiens	78	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome ubiquitination-pathway annotation (interaction of E3 with substrate and E2-Ub complex) placing FBXO7 in the cytosol.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	3	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (AcM-UBE2M transfers NEDD8 to CRL1) propagated to FBXW10 as an SCF subunit.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	4	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (NEDD8:AcM-UBE2M binds CRL1) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	5	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (CAND1 binds cytosolic CRL ligases) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	6	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COMMDs displace CAND1) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	7	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COP9 signalosome deneddylates CRLs) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	8	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (MyrG-DCUN1D3 binds CRL1) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	9	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (transfer of Ub from E2 to substrate) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	10	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (release of E3 from polyubiquitinated substrate) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	11	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (polyubiquitination of substrate) propagated to FBXW10.
human	FBXW10	genes/human/FBXW10/FBXW10-ai-review.yaml	FBXW10	Q5XX13	NCBITaxon:9606	Homo sapiens	12	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (interaction of E3 with substrate and E2-Ub complex) propagated to FBXW10.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	5	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (AcM-UBE2M transfers NEDD8 to CRL1) propagated to FBXW12 as an SCF subunit.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	6	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (NEDD8:AcM-UBE2M binds CRL1) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	7	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (CAND1 binds cytosolic CRL ligases) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	8	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COMMDs displace CAND1) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	9	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COP9 signalosome deneddylates CRLs) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	10	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (MyrG-DCUN1D3 binds CRL1) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	11	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (transfer of Ub from E2 to substrate) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	12	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (release of E3 from polyubiquitinated substrate) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	13	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (polyubiquitination of substrate) propagated to FBXW12.
human	FBXW12	genes/human/FBXW12/FBXW12-ai-review.yaml	FBXW12	Q6X9E4	NCBITaxon:9606	Homo sapiens	14	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (interaction of E3 with substrate and E2-Ub complex) propagated to FBXW12.
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	17	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions. Consistent with the expected cytosolic localization of a SCF substrate receptor.
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	18	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions.
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	19	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CAND1 binding to CRL).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	20	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COMMD-CAND1 displacement).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	21	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COP9 signalosome deneddylation).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	22	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (DCUN1D3 binding to CRL1).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	23	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (Ub transfer to substrate).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	24	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 release from polyubiquitinated substrate).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	25	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (polyubiquitination of substrate).
human	FBXW2	genes/human/FBXW2/FBXW2-ai-review.yaml	FBXW2	Q9UKT8	NCBITaxon:9606	Homo sapiens	26	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 interaction with substrate and E2-Ub).
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	10	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization for FBXW4 within generic CRL1/SCF neddylation and ubiquitination reactions.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	11	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (NEDD8:AcM-UBE2M binds CRL1) propagated to FBXW4 as an SCF subunit.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	12	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (CAND1 binds cytosolic CRL ligases) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	13	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COMMDs displace CAND1) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	14	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COP9 signalosome deneddylates CRLs) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	15	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (MyrG-DCUN1D3 binds CRL1) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	16	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (transfer of Ub from E2 to substrate) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	17	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (release of E3 from polyubiquitinated substrate) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	18	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (polyubiquitination of substrate) propagated to FBXW4.
human	FBXW4	genes/human/FBXW4/FBXW4-ai-review.yaml	FBXW4	P57775	NCBITaxon:9606	Homo sapiens	19	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (interaction of E3 with substrate and E2-Ub complex) propagated to FBXW4.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	21	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions. Consistent with the documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	22	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions. Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	23	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CAND1 binding to CRL). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	24	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COMMD-CAND1 displacement). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	25	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COP9 signalosome deneddylation). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	26	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (DCUN1D3 binding to CRL1). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	27	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (Ub transfer to substrate). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	28	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 release from polyubiquitinated substrate). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	29	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (polyubiquitination of substrate). Consistent with documented cytoplasmic localization.
human	FBXW5	genes/human/FBXW5/FBXW5-ai-review.yaml	FBXW5	Q969U6	NCBITaxon:9606	Homo sapiens	30	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 interaction with substrate and E2-Ub). Consistent with documented cytoplasmic localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	79	R-HSA-2220967	p-NICD1 PEST domain mutants do not bind FBXW7	yes	reactome/R-HSA-2220967.md	p-NICD1 PEST domain mutants do not bind FBXW7	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXW7 nucleoplasm localization (NICD1 phosphodegron mutants). Correct localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	80	R-NUL-2064853	FBXW7 binds phosphorylated NICD1	yes	reactome/R-NUL-2064853.md	FBXW7 binds phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXW7 nucleoplasm localization (binds phosphorylated NICD1). Correct localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	81	R-NUL-2064883	FBXW7 mediates ubiquitination of phosphorylated NICD1	yes	reactome/R-NUL-2064883.md	FBXW7 mediates ubiquitination of phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXW7 nucleoplasm localization (ubiquitinates phosphorylated NICD1). Correct localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	82	R-NUL-9604628	FBXW7 promotes ubiquitination of mouse p-NICD4	yes	reactome/R-NUL-9604628.md	FBXW7 promotes ubiquitination of mouse p-NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXW7 nucleoplasm localization (promotes ubiquitination of mouse p-NICD4). Correct localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	101	R-HSA-2220978	FBXW7 WD mutants do not bind NICD1	yes	reactome/R-HSA-2220978.md	FBXW7 WD mutants do not bind NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation of FBXW7 nucleoplasm localization (WD mutants do not bind NICD1). Correct localization.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	102	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization within CRL1 neddylation reactions. Consistent with the cytoplasmic FBXW7 pool/SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	103	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (NEDD8:UBE2M binds CRL1). Consistent with cytoplasmic SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	104	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (CAND1 binds cytosolic CRLs). Consistent with cytoplasmic SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	105	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COMMDs displace CAND1). Consistent with cytoplasmic SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	106	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (COP9 signalosome deneddylates CRLs). Consistent with cytoplasmic SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	107	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (DCUN1D3 binds CRL1). Consistent with cytoplasmic SCF assembly.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	108	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate). Consistent with cytoplasmic SCF function.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	109	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Consistent with cytoplasmic SCF function.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	110	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (polyubiquitination of substrate). Consistent with cytoplasmic SCF function.
human	FBXW7	genes/human/FBXW7/FBXW7-ai-review.yaml	FBXW7	Q969H0	NCBITaxon:9606	Homo sapiens	111	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub). Consistent with cytoplasmic SCF function.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	49	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions. Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	50	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization within CRL neddylation reactions. Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	51	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (CAND1 binding to CRL). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	52	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COMMD-CAND1 displacement). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	53	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (COP9 signalosome deneddylation). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	54	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (DCUN1D3 binding to CRL1). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	55	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (Ub transfer to substrate). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	56	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 release from polyubiquitinated substrate). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	57	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (polyubiquitination of substrate). Consistent with documented cytoplasmic localization.
human	FBXW8	genes/human/FBXW8/FBXW8-ai-review.yaml	FBXW8	Q8N3Y1	NCBITaxon:9606	Homo sapiens	58	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (E3 interaction with substrate and E2-Ub). Consistent with documented cytoplasmic localization.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	7	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (AcM-UBE2M transfers NEDD8 to CRL1) propagated to FBXW9 as an SCF subunit.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	8	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (NEDD8:AcM-UBE2M binds CRL1) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	9	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (CAND1 binds cytosolic CRL ligases) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COMMDs displace CAND1) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	11	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (COP9 signalosome deneddylates CRLs) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	12	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (MyrG-DCUN1D3 binds CRL1) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	13	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (transfer of Ub from E2 to substrate) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	14	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (release of E3 from polyubiquitinated substrate) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	15	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (polyubiquitination of substrate) propagated to FBXW9.
human	FBXW9	genes/human/FBXW9/FBXW9-ai-review.yaml	FBXW9	Q5XUX1	NCBITaxon:9606	Homo sapiens	16	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-level cytosol localization (interaction of E3 with substrate and E2-Ub complex) propagated to FBXW9.
human	FDFT1	genes/human/FDFT1/FDFT1-ai-review.yaml	FDFT1	P37268	NCBITaxon:9606	Homo sapiens	19	R-HSA-1655850	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)	yes	reactome/R-HSA-1655850.md	Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (FDFT1 expression event) places the enzyme at the ER membrane. Consistent with all other localization evidence.
human	FDFT1	genes/human/FDFT1/FDFT1-ai-review.yaml	FDFT1	P37268	NCBITaxon:9606	Homo sapiens	20	R-HSA-191402	Reduction of presqualene diphosphate to form squalene	yes	reactome/R-HSA-191402.md	Reduction of presqualene diphosphate to form squalene	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction (reduction of presqualene diphosphate to squalene) is annotated to the ER membrane, where SQS acts.
human	FDFT1	genes/human/FDFT1/FDFT1-ai-review.yaml	FDFT1	P37268	NCBITaxon:9606	Homo sapiens	21	R-HSA-191405	Two FAPP molecules dimerize to form presqualene diphosphate	yes	reactome/R-HSA-191405.md	Two FAPP molecules dimerize to form presqualene diphosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction (dimerization of two FPP molecules to presqualene diphosphate) at the ER membrane, catalysed by FDFT1.
human	FDPS	genes/human/FDPS/FDPS-ai-review.yaml	FDPS	P14324	NCBITaxon:9606	Homo sapiens	21	R-HSA-1655824	Expression of Farnesyl Diphosphate Synthase (FDPS)	yes	reactome/R-HSA-1655824.md	Expression of Farnesyl Diphosphate Synthase (FDPS)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization, consistent with the UniProt subcellular location. Core localization; accept.
human	FDPS	genes/human/FDPS/FDPS-ai-review.yaml	FDPS	P14324	NCBITaxon:9606	Homo sapiens	22	R-HSA-191303	FDPS dimer transfers IPPP to GPP	yes	reactome/R-HSA-191303.md	FDPS dimer transfers IPPP to GPP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation attached to the FPP-forming reaction (FDPS dimer transfers IPPP to GPP). Consistent with UniProt; accept.
human	FDPS	genes/human/FDPS/FDPS-ai-review.yaml	FDPS	P14324	NCBITaxon:9606	Homo sapiens	23	R-HSA-191322	FDPS dimer transfers IPPP to DMAPP	yes	reactome/R-HSA-191322.md	FDPS dimer transfers IPPP to DMAPP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation attached to the GPP-forming reaction (FDPS dimer transfers IPPP to DMAPP). Consistent with UniProt; accept.
human	FDPS	genes/human/FDPS/FDPS-ai-review.yaml	FDPS	P14324	NCBITaxon:9606	Homo sapiens	24	R-HSA-9717841	holo-FDPS dimer binds NBPs	yes	reactome/R-HSA-9717841.md	holo-FDPS dimer binds NBPs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation attached to bisphosphonate binding by holo-FDPS. Consistent with UniProt; accept.
human	FECH	genes/human/FECH/FECH-ai-review.yaml	FECH	P22830	NCBITaxon:9606	Homo sapiens	34	R-HSA-189465	FECH binds Fe2+ to PRIN9 to form heme	yes	reactome/R-HSA-189465.md	FECH binds Fe2+ to PRIN9 to form heme	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the inner mitochondrial membrane for the reaction ""FECH binds Fe2+ to PRIN9 to form heme"". Correct specific localization."
human	FECH	genes/human/FECH/FECH-ai-review.yaml	FECH	P22830	NCBITaxon:9606	Homo sapiens	35	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to inner mitochondrial membrane (mitochondrial protein degradation context, CLPXP). Localization is correct.
human	FECH	genes/human/FECH/FECH-ai-review.yaml	FECH	P22830	NCBITaxon:9606	Homo sapiens	36	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to inner mitochondrial membrane (LONP1 degradation context). Localization is correct.
human	FECH	genes/human/FECH/FECH-ai-review.yaml	FECH	P22830	NCBITaxon:9606	Homo sapiens	37	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to inner mitochondrial membrane (LONP1 binding context). Localization is correct.
human	FECH	genes/human/FECH/FECH-ai-review.yaml	FECH	P22830	NCBITaxon:9606	Homo sapiens	38	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to inner mitochondrial membrane (CLPXP degradation context). Localization is correct.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	41	R-HSA-5693538	Homology Directed Repair	yes	reactome/R-HSA-5693538.md	Homology Directed Repair	Homo sapiens	GO:0000724	double-strand break repair via homologous recombination	TAS	involved_in	BP	false		MODIFY	Reactome TAS placing FEN1 in 'Homology Directed Repair'. Within Reactome, FEN1's actual reaction in that hierarchy is flap cleavage during microhomology-mediated end joining, not homologous recombination proper.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	42	R-HSA-174446	Removal of remaining Flap from the C-strand	yes	reactome/R-HSA-174446.md	Removal of remaining Flap from the C-strand	Homo sapiens	GO:0032201	telomere maintenance via semi-conservative replication	TAS	involved_in	BP	false		ACCEPT	Reactome TAS for telomere maintenance via semi-conservative replication, from the reaction 'Removal of remaining Flap from the C-strand'. Telomeric lagging-strand (C-strand) synthesis requires the same Okazaki flap processing that FEN1 performs genome-wide.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	46	R-HSA-110373	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	yes	reactome/R-HSA-110373.md	Resolution of AP sites via the multiple-nucleotide patch replacement pathway	Homo sapiens	GO:0006287	base-excision repair, gap-filling	TAS	involved_in	BP	false		ACCEPT	Reactome TAS for base-excision repair gap-filling, from 'Resolution of AP sites via the multiple-nucleotide patch replacement pathway' (long-patch BER). FEN1 excises the AP-site-containing flap created by strand-displacement synthesis.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	48	R-HSA-110363	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	yes	reactome/R-HSA-110363.md	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	Homo sapiens	GO:0017108	5'-flap endonuclease activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for 5'-flap endonuclease activity in the reaction 'FEN1 bound to PCNA and APEX1 cleaves flap ssDNA' (long-patch BER).
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	49	R-HSA-174446	Removal of remaining Flap from the C-strand	yes	reactome/R-HSA-174446.md	Removal of remaining Flap from the C-strand	Homo sapiens	GO:0017108	5'-flap endonuclease activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for 5'-flap endonuclease activity in 'Removal of remaining Flap from the C-strand' during telomere lagging-strand replication.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	50	R-HSA-5651782	FEN1 bound to POLB cleaves displaced DNA strand (flap)	yes	reactome/R-HSA-5651782.md	FEN1 bound to POLB cleaves displaced DNA strand (flap)	Homo sapiens	GO:0017108	5'-flap endonuclease activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for 5'-flap endonuclease activity in 'FEN1 bound to POLB cleaves displaced DNA strand (flap)' during long-patch BER.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	51	R-HSA-5687664	FEN1 cleaves displaced ssDNA flaps during MMEJ	yes	reactome/R-HSA-5687664.md	FEN1 cleaves displaced ssDNA flaps during MMEJ	Homo sapiens	GO:0017108	5'-flap endonuclease activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for 5'-flap endonuclease activity in 'FEN1 cleaves displaced ssDNA flaps during MMEJ'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	52	R-HSA-69152	Removal of remaining Flap	yes	reactome/R-HSA-69152.md	Removal of remaining Flap	Homo sapiens	GO:0017108	5'-flap endonuclease activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for 5'-flap endonuclease activity in 'Removal of remaining Flap' during Okazaki fragment processing.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	59	R-HSA-110363	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	yes	reactome/R-HSA-110363.md	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'FEN1 bound to PCNA and APEX1 cleaves flap ssDNA'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	60	R-HSA-110364	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	yes	reactome/R-HSA-110364.md	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	61	R-HSA-110368	POLD,POLE-mediated DNA strand displacement synthesis	yes	reactome/R-HSA-110368.md	POLD,POLE-mediated DNA strand displacement synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'POLD,POLE-mediated DNA strand displacement synthesis'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	62	R-HSA-174446	Removal of remaining Flap from the C-strand	yes	reactome/R-HSA-174446.md	Removal of remaining Flap from the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'Removal of remaining Flap from the C-strand'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	63	R-HSA-5649873	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site	yes	reactome/R-HSA-5649873.md	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	64	R-HSA-5649883	POLB-mediated DNA strand displacement synthesis	yes	reactome/R-HSA-5649883.md	POLB-mediated DNA strand displacement synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'POLB-mediated DNA strand displacement synthesis'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	65	R-HSA-5651723	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate	yes	reactome/R-HSA-5651723.md	PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	66	R-HSA-5651739	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB	yes	reactome/R-HSA-5651739.md	PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	67	R-HSA-5651782	FEN1 bound to POLB cleaves displaced DNA strand (flap)	yes	reactome/R-HSA-5651782.md	FEN1 bound to POLB cleaves displaced DNA strand (flap)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'FEN1 bound to POLB cleaves displaced DNA strand (flap)'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	68	R-HSA-5687484	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site	yes	reactome/R-HSA-5687484.md	PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	69	R-HSA-5687640	POLQ extends annealed 3'-ssDNA overhangs in MMEJ	yes	reactome/R-HSA-5687640.md	POLQ extends annealed 3'-ssDNA overhangs in MMEJ	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'POLQ extends annealed 3'-ssDNA overhangs in MMEJ'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	70	R-HSA-5687653	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate	yes	reactome/R-HSA-5687653.md	PARP1,PARP2 dimers bound to MMEJ sites autoPARylate	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'PARP1,PARP2 dimers bound to MMEJ sites autoPARylate'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	71	R-HSA-5687664	FEN1 cleaves displaced ssDNA flaps during MMEJ	yes	reactome/R-HSA-5687664.md	FEN1 cleaves displaced ssDNA flaps during MMEJ	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'FEN1 cleaves displaced ssDNA flaps during MMEJ'.
human	FEN1	genes/human/FEN1/FEN1-ai-review.yaml	FEN1	P39748	NCBITaxon:9606	Homo sapiens	72	R-HSA-69152	Removal of remaining Flap	yes	reactome/R-HSA-69152.md	Removal of remaining Flap	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS assigning FEN1 to the nucleoplasm as a participant in 'Removal of remaining Flap'.
human	FERMT2	genes/human/FERMT2/FERMT2-ai-review.yaml	FERMT2	Q96AC1	NCBITaxon:9606	Homo sapiens	71	R-HSA-430341	Mig-2 recruits Migfilin to the cell-ECM adhesions	yes	reactome/R-HSA-430341.md	Mig-2 recruits Migfilin to the cell-ECM adhesions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool (IDA/TAS) of kindlin-2 before/while it is recruited to membrane adhesion sites; consistent with a soluble cytoplasmic adapter.
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	31	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	32	R-HSA-1839094	Activated FGFR1 mutants and fusions bind PLCG1	yes	reactome/R-HSA-1839094.md	Activated FGFR1 mutants and fusions bind PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	33	R-HSA-1839098	Activated FGFR1 mutants and fusions phosphorylate PLCG1	yes	reactome/R-HSA-1839098.md	Activated FGFR1 mutants and fusions phosphorylate PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	34	R-HSA-1839100	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions	yes	reactome/R-HSA-1839100.md	p-4Y- PLCG1 dissociates from activated FGFR1 mutants and fusions	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	35	R-HSA-190256	FGFR1c binds to FGF	yes	reactome/R-HSA-190256.md	FGFR1c binds to FGF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	36	R-HSA-190258	FGFR2c binds to FGF	yes	reactome/R-HSA-190258.md	FGFR2c binds to FGF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	37	R-HSA-190261	FGFR3c binds to FGF	yes	reactome/R-HSA-190261.md	FGFR3c binds to FGF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	38	R-HSA-190263	FGFR3b binds to FGF	yes	reactome/R-HSA-190263.md	FGFR3b binds to FGF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	39	R-HSA-190265	FGFR4 binds to FGF	yes	reactome/R-HSA-190265.md	FGFR4 binds to FGF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	40	R-HSA-190326	Autocatalytic phosphorylation of FGFR4	yes	reactome/R-HSA-190326.md	Autocatalytic phosphorylation of FGFR4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	41	R-HSA-190385	Autocatalytic phosphorylation of FGFR3b	yes	reactome/R-HSA-190385.md	Autocatalytic phosphorylation of FGFR3b	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	42	R-HSA-190388	Autocatalytic phosphorylation of FGFR3c	yes	reactome/R-HSA-190388.md	Autocatalytic phosphorylation of FGFR3c	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	43	R-HSA-190413	Autocatalytic phosphorylation of FGFR2c	yes	reactome/R-HSA-190413.md	Autocatalytic phosphorylation of FGFR2c	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	44	R-HSA-190429	Autocatalytic phosphorylation of FGFR1c	yes	reactome/R-HSA-190429.md	Autocatalytic phosphorylation of FGFR1c	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	45	R-HSA-2012073	Autocatalytic phosphorylation of FGFR3c P250R mutant	yes	reactome/R-HSA-2012073.md	Autocatalytic phosphorylation of FGFR3c P250R mutant	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	46	R-HSA-2012074	FGFR3c P250R mutant binds to ligand with enhanced affinity	yes	reactome/R-HSA-2012074.md	FGFR3c P250R mutant binds to ligand with enhanced affinity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	47	R-HSA-2023451	FGFR1c P252X mutants bind ligand with enhanced affinity	yes	reactome/R-HSA-2023451.md	FGFR1c P252X mutants bind ligand with enhanced affinity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	48	R-HSA-2023455	Autocatalytic phosphorylation of FGFR1c P252X mutant dimers	yes	reactome/R-HSA-2023455.md	Autocatalytic phosphorylation of FGFR1c P252X mutant dimers	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	49	R-HSA-2033472	FGFR2c mutants bind an expanded range of ligands	yes	reactome/R-HSA-2033472.md	FGFR2c mutants bind an expanded range of ligands	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	50	R-HSA-2033486	Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding	yes	reactome/R-HSA-2033486.md	Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	51	R-HSA-2077420	FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors	yes	reactome/R-HSA-2077420.md	FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	52	R-HSA-2077424	Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors	yes	reactome/R-HSA-2077424.md	Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	53	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	54	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	55	R-HSA-5654147	Activated FGFR2 phosphorylates PLCG1	yes	reactome/R-HSA-5654147.md	Activated FGFR2 phosphorylates PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	56	R-HSA-5654148	p-4Y-PLCG1 dissociates from activated FGFR3	yes	reactome/R-HSA-5654148.md	p-4Y-PLCG1 dissociates from activated FGFR3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	57	R-HSA-5654149	Activated FGFR1 phosphorylates PLCG1	yes	reactome/R-HSA-5654149.md	Activated FGFR1 phosphorylates PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	58	R-HSA-5654151	Activated FGFR4 phosphorylates PLCG1	yes	reactome/R-HSA-5654151.md	Activated FGFR4 phosphorylates PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	59	R-HSA-5654157	p-4Y-PLCG1 dissociates from activated FGFR2	yes	reactome/R-HSA-5654157.md	p-4Y-PLCG1 dissociates from activated FGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	60	R-HSA-5654159	Activated FGFR2 binds PLCG1	yes	reactome/R-HSA-5654159.md	Activated FGFR2 binds PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	61	R-HSA-5654163	Activated FGFR4 binds PLCG1	yes	reactome/R-HSA-5654163.md	Activated FGFR4 binds PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	62	R-HSA-5654165	p-4Y-PLCG1 dissociates from activated FGFR1	yes	reactome/R-HSA-5654165.md	p-4Y-PLCG1 dissociates from activated FGFR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	63	R-HSA-5654167	Activated FGFR1 binds PLCG1	yes	reactome/R-HSA-5654167.md	Activated FGFR1 binds PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	64	R-HSA-5654169	p-4Y-PLCG1 dissociates from activated FGFR4	yes	reactome/R-HSA-5654169.md	p-4Y-PLCG1 dissociates from activated FGFR4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	65	R-HSA-5654222	Activated FGFR3 phosphorylates PLCG1	yes	reactome/R-HSA-5654222.md	Activated FGFR3 phosphorylates PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	66	R-HSA-5654224	Activated FGFR3 binds PLCG1	yes	reactome/R-HSA-5654224.md	Activated FGFR3 binds PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	67	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	68	R-HSA-5654397	Activated FGFR2 phosphorylates FRS2	yes	reactome/R-HSA-5654397.md	Activated FGFR2 phosphorylates FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	69	R-HSA-5654399	Activated FGFR2 binds FRS2	yes	reactome/R-HSA-5654399.md	Activated FGFR2 binds FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	70	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	71	R-HSA-5654404	Activated FGFR2 binds SHC1	yes	reactome/R-HSA-5654404.md	Activated FGFR2 binds SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	72	R-HSA-5654406	Activated FGFR2:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654406.md	Activated FGFR2:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	73	R-HSA-5654407	Activated FGFR2 phosphorylates SHC1	yes	reactome/R-HSA-5654407.md	Activated FGFR2 phosphorylates SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	74	R-HSA-5654408	Activated FGFR3 phosphorylates FRS2	yes	reactome/R-HSA-5654408.md	Activated FGFR3 phosphorylates FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	75	R-HSA-5654409	Activated FGFR3 binds FRS2	yes	reactome/R-HSA-5654409.md	Activated FGFR3 binds FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	76	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	77	R-HSA-5654416	Activated FGFR3:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654416.md	Activated FGFR3:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	78	R-HSA-5654418	Activated FGFR4 phosphorylates FRS2	yes	reactome/R-HSA-5654418.md	Activated FGFR4 phosphorylates FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	79	R-HSA-5654422	Activated FGFR4 binds FRS2	yes	reactome/R-HSA-5654422.md	Activated FGFR4 binds FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	80	R-HSA-5654423	Activated FGFR4:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654423.md	Activated FGFR4:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	81	R-HSA-5654425	Activated FGFR4 binds SHC1	yes	reactome/R-HSA-5654425.md	Activated FGFR4 binds SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	82	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	83	R-HSA-5654428	Activated FGFR4 phosphorylates SHC1	yes	reactome/R-HSA-5654428.md	Activated FGFR4 phosphorylates SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	84	R-HSA-5654511	FGFRL1 dimer binds FGFs	yes	reactome/R-HSA-5654511.md	FGFRL1 dimer binds FGFs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	85	R-HSA-5654560	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2	yes	reactome/R-HSA-5654560.md	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	86	R-HSA-5654562	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2	yes	reactome/R-HSA-5654562.md	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	87	R-HSA-5654565	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2	yes	reactome/R-HSA-5654565.md	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	88	R-HSA-5654566	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2	yes	reactome/R-HSA-5654566.md	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	89	R-HSA-5654569	Activated FGFR1 binds FRS2	yes	reactome/R-HSA-5654569.md	Activated FGFR1 binds FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	90	R-HSA-5654571	Activated FGFR1 binds FRS3	yes	reactome/R-HSA-5654571.md	Activated FGFR1 binds FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	91	R-HSA-5654573	Activated FGFR1 binds SHC1	yes	reactome/R-HSA-5654573.md	Activated FGFR1 binds SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	92	R-HSA-5654575	Activated FGFR1 phosphorylates FRS2	yes	reactome/R-HSA-5654575.md	Activated FGFR1 phosphorylates FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	93	R-HSA-5654578	Activated FGFR1 phosphorylates FRS3	yes	reactome/R-HSA-5654578.md	Activated FGFR1 phosphorylates FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	94	R-HSA-5654582	Activated FGFR1 phosphorylates SHC1	yes	reactome/R-HSA-5654582.md	Activated FGFR1 phosphorylates SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	95	R-HSA-5654584	Activated FGFR1:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654584.md	Activated FGFR1:p-FRS bind to PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	96	R-HSA-5654586	Activated FGFR1:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654586.md	Activated FGFR1:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	97	R-HSA-5654587	Activated FGFR1:p-FRS phosphorylates PPTN11	yes	reactome/R-HSA-5654587.md	Activated FGFR1:p-FRS phosphorylates PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	98	R-HSA-5654591	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654591.md	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	99	R-HSA-5654592	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654592.md	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	100	R-HSA-5654594	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654594.md	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	101	R-HSA-5654596	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654596.md	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	102	R-HSA-5654597	Activated FGFR1:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654597.md	Activated FGFR1:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	103	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	104	R-HSA-5654603	Activated FGFR2 binds FRS3	yes	reactome/R-HSA-5654603.md	Activated FGFR2 binds FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	105	R-HSA-5654605	Activated FGFR2 phosphorylates FRS3	yes	reactome/R-HSA-5654605.md	Activated FGFR2 phosphorylates FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	106	R-HSA-5654607	Activated FGFR2 phosphorylates PPTN11	yes	reactome/R-HSA-5654607.md	Activated FGFR2 phosphorylates PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	107	R-HSA-5654608	Activated FGFR2:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654608.md	Activated FGFR2:p-FRS bind to PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	108	R-HSA-5654612	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654612.md	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	109	R-HSA-5654614	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654614.md	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	110	R-HSA-5654615	Activated FGFR2:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654615.md	Activated FGFR2:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	111	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	112	R-HSA-5654620	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654620.md	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	113	R-HSA-5654622	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	114	R-HSA-5654623	Activated FGFR3 binds FRS3	yes	reactome/R-HSA-5654623.md	Activated FGFR3 binds FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	115	R-HSA-5654625	Activated FGFR3 binds SHC1	yes	reactome/R-HSA-5654625.md	Activated FGFR3 binds SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	116	R-HSA-5654628	Activated FGFR3 phosphorylates FRS3	yes	reactome/R-HSA-5654628.md	Activated FGFR3 phosphorylates FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	117	R-HSA-5654631	Activated FGFR3 phosphorylates PPTN11	yes	reactome/R-HSA-5654631.md	Activated FGFR3 phosphorylates PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	118	R-HSA-5654633	Activated FGFR3:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654633.md	Activated FGFR3:p-FRS bind to PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	119	R-HSA-5654634	Activated FGFR3 phosphorylates SHC1	yes	reactome/R-HSA-5654634.md	Activated FGFR3 phosphorylates SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	120	R-HSA-5654637	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654637.md	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	121	R-HSA-5654640	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654640.md	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	122	R-HSA-5654641	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654641.md	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	123	R-HSA-5654643	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654643.md	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	124	R-HSA-5654646	Activated FGFR3:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654646.md	Activated FGFR3:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	125	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	126	R-HSA-5654651	Activated FGFR4 binds FRS3	yes	reactome/R-HSA-5654651.md	Activated FGFR4 binds FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	127	R-HSA-5654653	Activated FGFR4 phosphorylates FRS3	yes	reactome/R-HSA-5654653.md	Activated FGFR4 phosphorylates FRS3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	128	R-HSA-5654655	Activated FGFR4 phosphorylates PPTN11	yes	reactome/R-HSA-5654655.md	Activated FGFR4 phosphorylates PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	129	R-HSA-5654658	Activated FGFR4:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654658.md	Activated FGFR4:p-FRS bind to PPTN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	130	R-HSA-5654659	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654659.md	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	131	R-HSA-5654662	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654662.md	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	132	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	133	R-HSA-5654664	Activated FGFR4:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654664.md	Activated FGFR4:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	134	R-HSA-5654667	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654667.md	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	135	R-HSA-5654669	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	136	R-HSA-5654672	CBL ubiquitinates FRS2 and FGFR1	yes	reactome/R-HSA-5654672.md	CBL ubiquitinates FRS2 and FGFR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	137	R-HSA-5654673	p-CBL:GRB2 binds p-FRS2:activated FGFR1	yes	reactome/R-HSA-5654673.md	p-CBL:GRB2 binds p-FRS2:activated FGFR1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	138	R-HSA-5654677	CBL ubiquitinates FRS2 and FGFR2	yes	reactome/R-HSA-5654677.md	CBL ubiquitinates FRS2 and FGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	139	R-HSA-5654679	CBL ubiquitinates FRS2 and FGFR3	yes	reactome/R-HSA-5654679.md	CBL ubiquitinates FRS2 and FGFR3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	140	R-HSA-5654684	CBL ubiquitinates FRS2 and FGFR4	yes	reactome/R-HSA-5654684.md	CBL ubiquitinates FRS2 and FGFR4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	141	R-HSA-5654690	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654690.md	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	142	R-HSA-5654692	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654692.md	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	143	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	144	R-HSA-5654701	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654701.md	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	145	R-HSA-5654705	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654705.md	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	146	R-HSA-5654709	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654709.md	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	147	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	148	R-HSA-5654717	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654717.md	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	149	R-HSA-5654729	p-CBL:GRB2 binds p-FRS2:activated FGFR2	yes	reactome/R-HSA-5654729.md	p-CBL:GRB2 binds p-FRS2:activated FGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	150	R-HSA-5654730	p-CBL:GRB2 binds p-FRS2:activated FGFR3	yes	reactome/R-HSA-5654730.md	p-CBL:GRB2 binds p-FRS2:activated FGFR3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	151	R-HSA-5654734	p-CBL:GRB2 binds p-FRS2:activated FGFR4	yes	reactome/R-HSA-5654734.md	p-CBL:GRB2 binds p-FRS2:activated FGFR4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	152	R-HSA-5654748	p-4Y-PLCG1 dissociates from activated FGFR2 mutants	yes	reactome/R-HSA-5654748.md	p-4Y-PLCG1 dissociates from activated FGFR2 mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	153	R-HSA-5655233	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655233.md	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	154	R-HSA-5655240	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655240.md	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	155	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	156	R-HSA-5655243	Activated FGFR3 point and translocation mutants phosphorylate PLCG1	yes	reactome/R-HSA-5655243.md	Activated FGFR3 point and translocation mutants phosphorylate PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	157	R-HSA-5655244	Activated FGFR3 point and translocation mutants bind PLCG1	yes	reactome/R-HSA-5655244.md	Activated FGFR3 point and translocation mutants bind PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	158	R-HSA-5655245	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655245.md	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	159	R-HSA-5655247	p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants	yes	reactome/R-HSA-5655247.md	p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	160	R-HSA-5655262	Activated FGFR3 point, translocation and fusion mutants bind FRS2	yes	reactome/R-HSA-5655262.md	Activated FGFR3 point, translocation and fusion mutants bind FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	161	R-HSA-5655263	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655263.md	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	162	R-HSA-5655266	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655266.md	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	163	R-HSA-5655268	Activated FGFR2 mutants phosphorylate FRS2	yes	reactome/R-HSA-5655268.md	Activated FGFR2 mutants phosphorylate FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	164	R-HSA-5655269	Activated FGFR1 mutants bind FRS2	yes	reactome/R-HSA-5655269.md	Activated FGFR1 mutants bind FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	165	R-HSA-5655270	Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2	yes	reactome/R-HSA-5655270.md	Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	166	R-HSA-5655277	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	167	R-HSA-5655278	Activated FGFR1 mutants phosphorylate FRS2	yes	reactome/R-HSA-5655278.md	Activated FGFR1 mutants phosphorylate FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	168	R-HSA-5655285	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655285.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	169	R-HSA-5655289	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655289.md	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	170	R-HSA-5655290	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	171	R-HSA-5655295	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655295.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	172	R-HSA-5655301	Activated FGFR2 mutants phosphorylate PLCG1	yes	reactome/R-HSA-5655301.md	Activated FGFR2 mutants phosphorylate PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	173	R-HSA-5655315	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655315.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	174	R-HSA-5655320	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655320.md	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	175	R-HSA-5655323	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	176	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	177	R-HSA-5655339	Activated FGFR2 mutants bind FRS2	yes	reactome/R-HSA-5655339.md	Activated FGFR2 mutants bind FRS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	178	R-HSA-5655343	Activated FGFR2 mutants bind PLCG1	yes	reactome/R-HSA-5655343.md	Activated FGFR2 mutants bind PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	179	R-HSA-5656064	Activated FGFR1 binds FLRT1,2,3	yes	reactome/R-HSA-5656064.md	Activated FGFR1 binds FLRT1,2,3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGF8	genes/human/FGF8/FGF8-ai-review.yaml	FGF8	P55075	NCBITaxon:9606	Homo sapiens	180	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS).
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	59	R-HSA-5654748	p-4Y-PLCG1 dissociates from activated FGFR2 mutants	yes	reactome/R-HSA-5654748.md	p-4Y-PLCG1 dissociates from activated FGFR2 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Multiple Reactome entries document FGFR2 plasma membrane localization in various signaling contexts.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	60	R-HSA-5655233	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655233.md	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling. Duplicates other PM annotations.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	61	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Part of FGFR2 signaling pathway documentation.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	62	R-HSA-5655245	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655245.md	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 at plasma membrane.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	63	R-HSA-5655268	Activated FGFR2 mutants phosphorylate FRS2	yes	reactome/R-HSA-5655268.md	Activated FGFR2 mutants phosphorylate FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	64	R-HSA-5655301	Activated FGFR2 mutants phosphorylate PLCG1	yes	reactome/R-HSA-5655301.md	Activated FGFR2 mutants phosphorylate PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	65	R-HSA-5655320	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655320.md	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	66	R-HSA-5655323	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	67	R-HSA-5655339	Activated FGFR2 mutants bind FRS2	yes	reactome/R-HSA-5655339.md	Activated FGFR2 mutants bind FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	68	R-HSA-5655343	Activated FGFR2 mutants bind PLCG1	yes	reactome/R-HSA-5655343.md	Activated FGFR2 mutants bind PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 signaling.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	69	R-HSA-8853313	FGFR2 fusions autophosphorylate	yes	reactome/R-HSA-8853313.md	FGFR2 fusions autophosphorylate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for FGFR2 fusions autophosphorylation. Documents aberrant signaling in cancer.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	71	R-HSA-8853319	FGFR2 fusions dimerize	yes	reactome/R-HSA-8853319.md	FGFR2 fusions dimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for plasma membrane localization. FGFR2 transmembrane isoforms are plasma membrane receptors. Multiple Reactome pathways include FGFR2 at the plasma membrane.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	72	R-HSA-2029989	Autocatalytic phosphorylation of overexpressed FGFR2 variants	yes	reactome/R-HSA-2029989.md	Autocatalytic phosphorylation of overexpressed FGFR2 variants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate. Plasma membrane localization is well established for transmembrane FGFR2 isoforms.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	73	R-HSA-2029983	Dimerization of FGFR2 ligand-independent mutants	yes	reactome/R-HSA-2029983.md	Dimerization of FGFR2 ligand-independent mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	74	R-HSA-2029984	Autocatalytic phosphorylation of FGFR2 ligand-independent mutants	yes	reactome/R-HSA-2029984.md	Autocatalytic phosphorylation of FGFR2 ligand-independent mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	75	R-HSA-2033472	FGFR2c mutants bind an expanded range of ligands	yes	reactome/R-HSA-2033472.md	FGFR2c mutants bind an expanded range of ligands	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	76	R-HSA-2033474	FGFR2b mutants bind an expanded range of ligands	yes	reactome/R-HSA-2033474.md	FGFR2b mutants bind an expanded range of ligands	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	77	R-HSA-2033479	Dimerization of FGFR2 point mutants with enhanced kinase activity	yes	reactome/R-HSA-2033479.md	Dimerization of FGFR2 point mutants with enhanced kinase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	78	R-HSA-2033486	Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding	yes	reactome/R-HSA-2033486.md	Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	79	R-HSA-2033488	Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding	yes	reactome/R-HSA-2033488.md	Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	80	R-HSA-2033490	Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity	yes	reactome/R-HSA-2033490.md	Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	81	R-HSA-2077424	Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors	yes	reactome/R-HSA-2077424.md	Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	82	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	83	R-HSA-190413	Autocatalytic phosphorylation of FGFR2c	yes	reactome/R-HSA-190413.md	Autocatalytic phosphorylation of FGFR2c	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	84	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	85	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	86	R-HSA-5654147	Activated FGFR2 phosphorylates PLCG1	yes	reactome/R-HSA-5654147.md	Activated FGFR2 phosphorylates PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	87	R-HSA-5654157	p-4Y-PLCG1 dissociates from activated FGFR2	yes	reactome/R-HSA-5654157.md	p-4Y-PLCG1 dissociates from activated FGFR2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	88	R-HSA-5654159	Activated FGFR2 binds PLCG1	yes	reactome/R-HSA-5654159.md	Activated FGFR2 binds PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	89	R-HSA-5654397	Activated FGFR2 phosphorylates FRS2	yes	reactome/R-HSA-5654397.md	Activated FGFR2 phosphorylates FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	90	R-HSA-5654399	Activated FGFR2 binds FRS2	yes	reactome/R-HSA-5654399.md	Activated FGFR2 binds FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	91	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	92	R-HSA-5654404	Activated FGFR2 binds SHC1	yes	reactome/R-HSA-5654404.md	Activated FGFR2 binds SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	93	R-HSA-5654406	Activated FGFR2:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654406.md	Activated FGFR2:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	94	R-HSA-5654407	Activated FGFR2 phosphorylates SHC1	yes	reactome/R-HSA-5654407.md	Activated FGFR2 phosphorylates SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	95	R-HSA-5654562	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2	yes	reactome/R-HSA-5654562.md	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	96	R-HSA-5654603	Activated FGFR2 binds FRS3	yes	reactome/R-HSA-5654603.md	Activated FGFR2 binds FRS3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	97	R-HSA-5654605	Activated FGFR2 phosphorylates FRS3	yes	reactome/R-HSA-5654605.md	Activated FGFR2 phosphorylates FRS3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	98	R-HSA-5654607	Activated FGFR2 phosphorylates PPTN11	yes	reactome/R-HSA-5654607.md	Activated FGFR2 phosphorylates PPTN11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	99	R-HSA-5654608	Activated FGFR2:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654608.md	Activated FGFR2:p-FRS bind to PPTN11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	100	R-HSA-5654612	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654612.md	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	101	R-HSA-5654614	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654614.md	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	102	R-HSA-5654615	Activated FGFR2:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654615.md	Activated FGFR2:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	103	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	104	R-HSA-5654620	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654620.md	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	105	R-HSA-5654622	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	106	R-HSA-5654677	CBL ubiquitinates FRS2 and FGFR2	yes	reactome/R-HSA-5654677.md	CBL ubiquitinates FRS2 and FGFR2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	107	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	108	R-HSA-5654701	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654701.md	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	109	R-HSA-5654729	p-CBL:GRB2 binds p-FRS2:activated FGFR2	yes	reactome/R-HSA-5654729.md	p-CBL:GRB2 binds p-FRS2:activated FGFR2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	110	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	111	R-HSA-190258	FGFR2c binds to FGF	yes	reactome/R-HSA-190258.md	FGFR2c binds to FGF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	112	R-HSA-190260	FGFR2b binds to FGF	yes	reactome/R-HSA-190260.md	FGFR2b binds to FGF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	113	R-HSA-190408	Autocatalytic phosphorylation of FGFR2b	yes	reactome/R-HSA-190408.md	Autocatalytic phosphorylation of FGFR2b	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	114	R-NUL-8853328	Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors	yes	reactome/R-NUL-8853328.md	Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	115	R-HSA-2029988	Dimerization of overexpressed FGFR2	yes	reactome/R-HSA-2029988.md	Dimerization of overexpressed FGFR2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	116	R-HSA-2029992	Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants	yes	reactome/R-HSA-2029992.md	Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFR2	genes/human/FGFR2/FGFR2-ai-review.yaml	FGFR2	P21802	NCBITaxon:9606	Homo sapiens	117	R-HSA-2067713	GP369 inhibits activation of amplified FGFR2 signaling	yes	reactome/R-HSA-2067713.md	GP369 inhibits activation of amplified FGFR2 signaling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation duplicate for plasma membrane localization.
human	FGFRL1	genes/human/FGFRL1/FGFRL1-ai-review.yaml	FGFRL1	Q8N441	NCBITaxon:9606	Homo sapiens	21	R-HSA-5654510	FGFRL1 binds SPRED1/2	yes	reactome/R-HSA-5654510.md	FGFRL1 binds SPRED1/2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Plasma membrane localization annotation from Reactome pathway ""FGFRL1 binds SPRED1/2."" FGFRL1 interacts with SPRED proteins at the plasma membrane [Reactome:R-HSA-5654510]."
human	FGFRL1	genes/human/FGFRL1/FGFRL1-ai-review.yaml	FGFRL1	Q8N441	NCBITaxon:9606	Homo sapiens	22	R-HSA-5654511	FGFRL1 dimer binds FGFs	yes	reactome/R-HSA-5654511.md	FGFRL1 dimer binds FGFs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Plasma membrane localization annotation from Reactome pathway ""FGFRL1 dimer binds FGFs."" FGFRL1 dimers bind FGF ligands at the plasma membrane [Reactome:R-HSA-5654511]."
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	36	R-HSA-5618073	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-5618073.md	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation placing FKBP4 in the cytosol, consistent with its primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	37	R-HSA-5618080	Reactome: FKBP4 in cytosol/nucleoplasm.	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol, redundant with the primary cytosolic localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	38	R-HSA-5618085	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-5618085.md	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	39	R-HSA-5618099	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-5618099.md	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	40	R-HSA-5618110	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	41	R-HSA-9678925	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9678925.md	NR3C1 binds NR3C1 agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	42	R-HSA-9690534	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9690534.md	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	43	R-HSA-9705925	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9705925.md	Androgens binds AR (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	44	R-HSA-9705926	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9705926.md	AR binds AR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	45	R-HSA-9706837	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9706837.md	AR binds AR antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	46	R-HSA-9725855	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9725855.md	NR3C2 binds NR3C2 antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	47	R-HSA-9725885	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9725885.md	P4 bind PGR (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	48	R-HSA-9726509	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9726509.md	NR3C2 binds fludrocortisone	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	49	R-HSA-9726580	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9726580.md	PGR binds PGR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	50	R-HSA-9726621	Reactome: FKBP4 in cytosol.	yes	reactome/R-HSA-9726621.md	PGR binds PGR antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP4 in the cytosol; redundant with the primary localization.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	51	R-HSA-5324617	Reactome: FKBP4 in nucleoplasm.	yes	reactome/R-HSA-5324617.md	HSP90:FKBP4:PTGES3 binds HSF1 trimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing FKBP4 in the nucleoplasm, consistent with its nuclear pool and role in steroid receptor nuclear translocation.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	52	R-HSA-5618080	Reactome: FKBP4 in cytosol/nucleoplasm.	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing FKBP4 in the nucleoplasm; redundant with the nuclear pool annotation.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	53	R-HSA-5618093	Reactome: FKBP4 in nucleoplasm.	yes	reactome/R-HSA-5618093.md	ATP hydrolysis by HSP90	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing FKBP4 in the nucleoplasm; redundant with the nuclear pool annotation.
human	FKBP4	genes/human/FKBP4/FKBP4-ai-review.yaml	FKBP4	Q02790	NCBITaxon:9606	Homo sapiens	54	R-HSA-9038161	Reactome: FKBP4 in nucleoplasm.	yes	reactome/R-HSA-9038161.md	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing FKBP4 in the nucleoplasm; redundant with the nuclear pool annotation.
human	FKBP5	genes/human/FKBP5/FKBP5-ai-review.yaml	FKBP5	Q13451	NCBITaxon:9606	Homo sapiens	37	R-HSA-5618073	Reactome: FKBP5 in cytosol.	yes	reactome/R-HSA-5618073.md	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation placing FKBP5 in the cytosol, consistent with its primary localization.
human	FKBP5	genes/human/FKBP5/FKBP5-ai-review.yaml	FKBP5	Q13451	NCBITaxon:9606	Homo sapiens	38	R-HSA-5618098	Reactome: FKBP5 in cytosol.	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP5 in the cytosol; redundant with the primary localization.
human	FKBP5	genes/human/FKBP5/FKBP5-ai-review.yaml	FKBP5	Q13451	NCBITaxon:9606	Homo sapiens	39	R-HSA-5618105	Reactome: FKBP5 in cytosol.	yes	reactome/R-HSA-5618105.md	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP5 in the cytosol; redundant with the primary localization.
human	FKBP5	genes/human/FKBP5/FKBP5-ai-review.yaml	FKBP5	Q13451	NCBITaxon:9606	Homo sapiens	40	R-HSA-9909510	Reactome: FKBP5 in cytosol.	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP5 in the cytosol; redundant with the primary localization.
human	FKBP5	genes/human/FKBP5/FKBP5-ai-review.yaml	FKBP5	Q13451	NCBITaxon:9606	Homo sapiens	41	R-HSA-9909519	Reactome: FKBP5 in cytosol.	yes	reactome/R-HSA-9909519.md	IFI44, IFI44L binds FKBP5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing FKBP5 in the cytosol; redundant with the primary localization.
human	FKBPL	genes/human/FKBPL/FKBPL-ai-review.yaml	FKBPL	Q9UIM3	NCBITaxon:9606	Homo sapiens	8	R-HSA-8852362	Reactome: FKBPL in cytosol.	yes	reactome/R-HSA-8852362.md	GTSE1 binds CDKN1A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation placing FKBPL in the cytosol, consistent with its intracellular HSP90/p21 co-chaperone function. Falcon deep research independently describes FKBPL as primarily cytosolic, participating in Hsp90-mediated chaperone complexes.
human	FLAD1	genes/human/FLAD1/FLAD1-ai-review.yaml	FLAD1	Q8NFF5	NCBITaxon:9606	Homo sapiens	19	R-HSA-196843	Vitamin B2 (riboflavin) metabolism	yes	reactome/R-HSA-196843.md	Vitamin B2 (riboflavin) metabolism	Homo sapiens	GO:0006771	riboflavin metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-traceable assignment to riboflavin (vitamin B2) metabolism. FAD synthesis is the terminal branch of the riboflavin-to-FAD pathway, so this parent process is correct, though the more specific GO:0006747 FAD biosynthetic process better captures the direct role.
human	FLAD1	genes/human/FLAD1/FLAD1-ai-review.yaml	FLAD1	Q8NFF5	NCBITaxon:9606	Homo sapiens	20	R-HSA-196929	FLAD1 phosphorylates FMN	yes	reactome/R-HSA-196929.md	FLAD1 phosphorylates FMN	Homo sapiens	GO:0003919	FMN adenylyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation of the core FMN adenylyltransferase reaction (FLAD1 adenylylates FMN). Correct core molecular function.
human	FLAD1	genes/human/FLAD1/FLAD1-ai-review.yaml	FLAD1	Q8NFF5	NCBITaxon:9606	Homo sapiens	41	R-HSA-196929	FLAD1 phosphorylates FMN	yes	reactome/R-HSA-196929.md	FLAD1 phosphorylates FMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosol as the compartment for the FMN adenylyltransferase reaction, matching the cytosolic isoform 2. Correct localization.
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	13	R-HSA-6810357	Fillagrin and keratin intermediate filaments polymerize forming a network	yes	reactome/R-HSA-6810357.md	Fillagrin and keratin intermediate filaments polymerize forming a network	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Fillagrin and keratin intermediate filaments polymerize forming a network"". Profilaggrin and filaggrin are cytoplasmic throughout their working life, so the compartment is not wrong, but `cytosol` is far less informative than the granule and envelope terms that describe where filaggrin actually acts."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	14	R-HSA-6810937	Lamellar bodies bind the early cornified envelope	yes	reactome/R-HSA-6810937.md	Lamellar bodies bind the early cornified envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Lamellar bodies bind the early cornified envelope"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	15	R-HSA-6811539	Reinforcement of the Cornified Envelope	yes	reactome/R-HSA-6811539.md	Reinforcement of the Cornified Envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Reinforcement of the Cornified Envelope"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	16	R-HSA-6814298	Late envelope proteins bind cornified envelope:CDSN	yes	reactome/R-HSA-6814298.md	Late envelope proteins bind cornified envelope:CDSN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Late envelope proteins bind cornified envelope:CDSN"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	17	R-HSA-6814387	CASP14 cleaves filaggrin	yes	reactome/R-HSA-6814387.md	CASP14 cleaves filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""CASP14 cleaves filaggrin"". Caspase-14 cleavage of the filaggrin repeat unit is a genuine, experimentally mapped step in filaggrin catabolism [PMID:21654840], and it occurs in the cytoplasm of cornifying cells."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	18	R-HSA-6814734	CDSN binds the cornified envelope	yes	reactome/R-HSA-6814734.md	CDSN binds the cornified envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""CDSN binds the cornified envelope"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	19	R-HSA-8849797	Membrane proteases cleave Profilaggrin producing Filaggrin	yes	reactome/R-HSA-8849797.md	Membrane proteases cleave Profilaggrin producing Filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Membrane proteases cleave Profilaggrin producing Filaggrin"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	20	R-HSA-8934819	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin	yes	reactome/R-HSA-8934819.md	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Cytoplasmic proteases cleave Profilaggrin producing Filaggrin"". Same compartment call as the other Reactome cytosol rows."
human	FLG	genes/human/FLG/FLG-ai-review.yaml	FLG	P20930	NCBITaxon:9606	Homo sapiens	21	R-HSA-8942224	Filaggrin binds Keratin tonofilament:Desmosome	yes	reactome/R-HSA-8942224.md	Filaggrin binds Keratin tonofilament:Desmosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway assertion from ""Filaggrin binds Keratin tonofilament:Desmosome"". The underlying reaction is the keratin-binding activity of filaggrin, directly demonstrated in [PMID:6170061] and [PMID:7687298]; the derived annotation here is only the cytosolic compartment."
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	61	R-HSA-3788061	Fibronectin degradation by ADAM8	yes	reactome/R-HSA-3788061.md	Fibronectin degradation by ADAM8	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	62	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Fibronectin is synthesized and modified in the ER during secretion. Minor localization annotation.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	67	R-HSA-1566981	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS	yes	reactome/R-HSA-1566981.md	Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	68	R-HSA-202723	Integrin alpha5beta1 binds FN1 dimer	yes	reactome/R-HSA-202723.md	Integrin alpha5beta1 binds FN1 dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	69	R-HSA-216050	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix	yes	reactome/R-HSA-216050.md	Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	70	R-HSA-2327733	FN1 binds Collagen types I-V, VII	yes	reactome/R-HSA-2327733.md	FN1 binds Collagen types I-V, VII	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	71	R-HSA-2327746	FN1 aggregation	yes	reactome/R-HSA-2327746.md	FN1 aggregation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	72	R-HSA-2396337	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	yes	reactome/R-HSA-2396337.md	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	73	R-HSA-2533950	Fibronectin degradation by MMP14	yes	reactome/R-HSA-2533950.md	Fibronectin degradation by MMP14	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	74	R-HSA-2537665	Fibulin-1 and -2 bind fibronectin	yes	reactome/R-HSA-2537665.md	Fibulin-1 and -2 bind fibronectin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	75	R-HSA-2545196	FN1 dimerizes	yes	reactome/R-HSA-2545196.md	FN1 dimerizes	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	76	R-HSA-2681681	Tenascins C, R, (X, N) bind fibronectin matrix	yes	reactome/R-HSA-2681681.md	Tenascins C, R, (X, N) bind fibronectin matrix	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	77	R-HSA-2731141	Syndecan-1 binds fibronectin	yes	reactome/R-HSA-2731141.md	Syndecan-1 binds fibronectin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	78	R-HSA-349593	Interaction of integrin alphaIIbbeta3 with Fibronectin	yes	reactome/R-HSA-349593.md	Interaction of integrin alphaIIbbeta3 with Fibronectin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	79	R-HSA-354066	Translocation of PTK2 to Focal complexes	yes	reactome/R-HSA-354066.md	Translocation of PTK2 to Focal complexes	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	80	R-HSA-354073	Autophosphorylation of PTK2 at Y397	yes	reactome/R-HSA-354073.md	Autophosphorylation of PTK2 at Y397	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	81	R-HSA-354087	Recruitment of GRB2 to p-PTK2	yes	reactome/R-HSA-354087.md	Recruitment of GRB2 to p-PTK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	82	R-HSA-354124	Phosphorylation of pPTK2 by SRC	yes	reactome/R-HSA-354124.md	Phosphorylation of pPTK2 by SRC	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	83	R-HSA-354149	Interaction of integrin alphaIIb beta3 with Fibrinogen	yes	reactome/R-HSA-354149.md	Interaction of integrin alphaIIb beta3 with Fibrinogen	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	84	R-HSA-354165	Interaction of SOS with GRB2 bound to FADK1	yes	reactome/R-HSA-354165.md	Interaction of SOS with GRB2 bound to FADK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	85	R-HSA-372693	Phosphorylation of BCAR1 by SRC-PTK2 complex	yes	reactome/R-HSA-372693.md	Phosphorylation of BCAR1 by SRC-PTK2 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	86	R-HSA-372697	Crk binding to p130cas	yes	reactome/R-HSA-372697.md	Crk binding to p130cas	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	87	R-HSA-372705	Recruitment of BCAR1 to PTK2 complex	yes	reactome/R-HSA-372705.md	Recruitment of BCAR1 to PTK2 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	88	R-HSA-377640	Autophosphorylation of SRC	yes	reactome/R-HSA-377640.md	Autophosphorylation of SRC	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	89	R-HSA-377641	Clustering of Integrin alphaIIb beta3 complexes	yes	reactome/R-HSA-377641.md	Clustering of Integrin alphaIIb beta3 complexes	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	90	R-HSA-377643	Dephosphorylation of inactive SRC by PTPB1	yes	reactome/R-HSA-377643.md	Dephosphorylation of inactive SRC by PTPB1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	91	R-HSA-377644	Release of CSK from SRC	yes	reactome/R-HSA-377644.md	Release of CSK from SRC	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	92	R-HSA-3785684	Fibronectin degradation by CTSG	yes	reactome/R-HSA-3785684.md	Fibronectin degradation by CTSG	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	93	R-HSA-429415	SYK binds to integrin alphaIIb beta3	yes	reactome/R-HSA-429415.md	SYK binds to integrin alphaIIb beta3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	94	R-HSA-429441	SYK activation by SRC	yes	reactome/R-HSA-429441.md	SYK activation by SRC	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	95	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	96	R-HSA-6785895	Expression of IL4, IL13-upregulated extracellular proteins	yes	reactome/R-HSA-6785895.md	Expression of IL4, IL13-upregulated extracellular proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	97	R-HSA-9624017	p-SHC1 binds integrin alpha5beta1:fibronectin	yes	reactome/R-HSA-9624017.md	p-SHC1 binds integrin alpha5beta1:fibronectin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	98	R-HSA-9638552	SfaS binds the fibronectin matrix	yes	reactome/R-HSA-9638552.md	SfaS binds the fibronectin matrix	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	99	R-HSA-9865226	PP2A dephosphorylates serine-127 of YAP1	yes	reactome/R-HSA-9865226.md	PP2A dephosphorylates serine-127 of YAP1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	100	R-HSA-9932034	CsgA binds the fibronectin matrix	yes	reactome/R-HSA-9932034.md	CsgA binds the fibronectin matrix	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MODIFY	Extracellular region annotation - too general, should use extracellular matrix.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	101	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	Plasma fibronectin is stored in platelet alpha granules and released upon activation.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	103	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	104	R-HSA-9700190	ALK mutants bind SHC	yes	reactome/R-HSA-9700190.md	ALK mutants bind SHC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	105	R-HSA-9700193	ALK mutants phosphorylate SHC1	yes	reactome/R-HSA-9700193.md	ALK mutants phosphorylate SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	106	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	107	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	108	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	109	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	110	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	111	R-HSA-9724099	ALK mutants:p-3Y SHC binds GRB2	yes	reactome/R-HSA-9724099.md	ALK mutants:p-3Y SHC binds GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	112	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	125	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN1	genes/human/FN1/FN1-ai-review.yaml	FN1	P02751	NCBITaxon:9606	Homo sapiens	126	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Fibronectin interacts with integrins at the plasma membrane, but fibronectin itself is extracellular.
human	FN3K	genes/human/FN3K/FN3K-ai-review.yaml	FN3K	Q9H479	NCBITaxon:9606	Homo sapiens	10	R-HSA-163841	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	yes	reactome/R-HSA-163841.md	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Homo sapiens	GO:0043687	post-translational protein modification	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Questionable pathway assignment. R-HSA-163841 covers gamma carboxylation, hypusinylation, hydroxylation - irreversible PTMs. FN3K is involved in REMOVING glycation (deglycation), not adding PTMs. The phosphorylation FN3K performs on glycated substrates is transient and part of a repair process, not a stable modification. This annotation may be misleading about FN3K's actual function.
human	FN3K	genes/human/FN3K/FN3K-ai-review.yaml	FN3K	Q9H479	NCBITaxon:9606	Homo sapiens	12	R-HSA-6788867	FN3K phosphorylates ketosamines	yes	reactome/R-HSA-6788867.md	FN3K phosphorylates ketosamines	Homo sapiens	GO:0016301	kinase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Third annotation to the same generic term. Correct but too general - the specific protein-fructosamine 3-kinase activity (GO:0102194) should be preferred. Keeping consistent with other kinase activity annotations.
human	FN3K	genes/human/FN3K/FN3K-ai-review.yaml	FN3K	Q9H479	NCBITaxon:9606	Homo sapiens	18	R-HSA-6788867	FN3K phosphorylates ketosamines	yes	reactome/R-HSA-6788867.md	FN3K phosphorylates ketosamines	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway. Consistent with other evidence supporting cytosolic localization.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	55	R-HSA-201640	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha	yes	reactome/R-HSA-201640.md	Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing FNTA to the cytosol (in the context of caspase-mediated cleavage of the FTase/GGTase alpha subunit). Consistent with FNTA being a soluble cytosolic protein. Accepted as a location.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	56	R-HSA-2530501	FNTA:FNTB transfers FARN to GNGT1	yes	reactome/R-HSA-2530501.md	FNTA:FNTB transfers FARN to GNGT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the context of FNTA:FNTB farnesylating the G-protein gamma subunit GNGT1. Accurate cytosolic location; duplicative of other cytosol annotations.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	57	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the RAS-processing context (pro-RAS farnesylation). Accurate cytosolic location; duplicative.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	58	R-HSA-9647987	FNTB inhibitors bind FNTA:FNTB	yes	reactome/R-HSA-9647987.md	FNTB inhibitors bind FNTA:FNTB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the context of FNTB inhibitors binding FNTA:FNTB. Accurate cytosolic location; duplicative.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	59	R-HSA-9947999	FNTA:PGGT1B geranylgeranylates GBP2	yes	reactome/R-HSA-9947999.md	FNTA:PGGT1B geranylgeranylates GBP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the context of FNTA:PGGT1B geranylgeranylating GBP2. Accurate cytosolic location; duplicative.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	60	R-HSA-9948016	FNTA:FNTB transfers farnesyl to GBP1	yes	reactome/R-HSA-9948016.md	FNTA:FNTB transfers farnesyl to GBP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the context of FNTA:FNTB transferring farnesyl to GBP1. Accurate cytosolic location; duplicative.
human	FNTA	genes/human/FNTA/FNTA-ai-review.yaml	FNTA	P49354	NCBITaxon:9606	Homo sapiens	61	R-HSA-9954195	FNTA:PGGT1B geranylgeranylates GBP5	yes	reactome/R-HSA-9954195.md	FNTA:PGGT1B geranylgeranylates GBP5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (cytosol) in the context of FNTA:PGGT1B geranylgeranylating GBP5. Accurate cytosolic location; duplicative.
human	FNTB	genes/human/FNTB/FNTB-ai-review.yaml	FNTB	P49356	NCBITaxon:9606	Homo sapiens	32	R-HSA-2530501	FNTA:FNTB transfers FARN to GNGT1	yes	reactome/R-HSA-2530501.md	FNTA:FNTB transfers FARN to GNGT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to cytosol. FTase is a soluble cytosolic enzyme, consistent with its role in prenylating substrates prior to membrane targeting. Accept as core localization.
human	FNTB	genes/human/FNTB/FNTB-ai-review.yaml	FNTB	P49356	NCBITaxon:9606	Homo sapiens	33	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) cytosol localization, in the context of RAS processing. Consistent with the soluble cytosolic FTase enzyme. Accept (redundant with other cytosol annotations).
human	FNTB	genes/human/FNTB/FNTB-ai-review.yaml	FNTB	P49356	NCBITaxon:9606	Homo sapiens	34	R-HSA-9647987	FNTB inhibitors bind FNTA:FNTB	yes	reactome/R-HSA-9647987.md	FNTB inhibitors bind FNTA:FNTB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) cytosol localization. Consistent with the soluble cytosolic FTase enzyme. Accept (redundant).
human	FNTB	genes/human/FNTB/FNTB-ai-review.yaml	FNTB	P49356	NCBITaxon:9606	Homo sapiens	35	R-HSA-9948016	FNTA:FNTB transfers farnesyl to GBP1	yes	reactome/R-HSA-9948016.md	FNTA:FNTB transfers farnesyl to GBP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) cytosol localization, in the GBP1 farnesylation context. Consistent with the soluble cytosolic FTase enzyme. Accept (redundant).
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	62	R-HSA-5692779	p-T182 MAPKAPK5 phosphorylates FOXO1	yes	reactome/R-HSA-5692779.md	p-T182 MAPKAPK5 phosphorylates FOXO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPKAPK5 phosphorylates FOXO1 in nucleoplasm.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	63	R-HSA-5692785	p-S215 FOXO1 binds RAG gene	yes	reactome/R-HSA-5692785.md	p-S215 FOXO1 binds RAG gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Phosphorylated FOXO1 binds RAG gene in nucleoplasm.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	95	R-HSA-211178	Phosphorylated FOXO1A is excluded from the nucleus	yes	reactome/R-HSA-211178.md	Phosphorylated FOXO1A is excluded from the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Phosphorylated FOXO1 is excluded from nucleus and found in cytosol.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	96	R-HSA-9614414	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol	yes	reactome/R-HSA-9614414.md	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	AKT-phosphorylated FOXO translocates to cytosol.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	97	R-HSA-9614423	14-3-3 proteins bind AKT-phosphorylated FOXO1	yes	reactome/R-HSA-9614423.md	14-3-3 proteins bind AKT-phosphorylated FOXO1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 binds phosphorylated FOXO1 in cytosol.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	100	R-HSA-199299	AKT phosphorylates FOXO transcription factors	yes	reactome/R-HSA-199299.md	AKT phosphorylates FOXO transcription factors	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates FOXO transcription factors in nucleoplasm.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	101	R-HSA-211164	AKT phosphorylates FOXO1A	yes	reactome/R-HSA-211164.md	AKT phosphorylates FOXO1A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT phosphorylates FOXO1A in nucleoplasm.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	102	R-HSA-211178	Phosphorylated FOXO1A is excluded from the nucleus	yes	reactome/R-HSA-211178.md	Phosphorylated FOXO1A is excluded from the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Phosphorylated FOXO1A is excluded from the nucleus.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	103	R-HSA-2399992	AKT1 E17K mutant phosphorylates forkhead box transcription factors	yes	reactome/R-HSA-2399992.md	AKT1 E17K mutant phosphorylates forkhead box transcription factors	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT1 E17K mutant phosphorylates FOXO transcription factors.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	104	R-HSA-6790036	Expression of STAT3-upregulated nuclear proteins	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	STAT3-upregulated nuclear proteins including FOXO.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	105	R-HSA-9614414	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol	yes	reactome/R-HSA-9614414.md	AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	AKT-phosphorylated FOXOs translocate to cytosol.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	106	R-HSA-9614662	FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter	yes	reactome/R-HSA-9614662.md	FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds FASLG gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	107	R-HSA-9617840	FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter	yes	reactome/R-HSA-9617840.md	FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds CDKN1A gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	108	R-HSA-9617996	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4	yes	reactome/R-HSA-9617996.md	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds SMAD2/3:SMAD4 complex.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	109	R-HSA-9622980	FOXO1 binds NPY gene promoter	yes	reactome/R-HSA-9622980.md	FOXO1 binds NPY gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds NPY gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	110	R-HSA-9623415	FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter	yes	reactome/R-HSA-9623415.md	FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds IGFBP1 gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	111	R-HSA-9624976	FOXO1,FOXO3 binds CAV1 gene promoter	yes	reactome/R-HSA-9624976.md	FOXO1,FOXO3 binds CAV1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds CAV1 gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	112	R-HSA-9625091	FOXO1,FOXO3 bind ABCA6 gene promoter	yes	reactome/R-HSA-9625091.md	FOXO1,FOXO3 bind ABCA6 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds ABCA6 gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	113	R-HSA-9626928	CREBBP binds FOXO1	yes	reactome/R-HSA-9626928.md	CREBBP binds FOXO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	CREBBP binds FOXO1.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	114	R-NUL-9620806	FOXO1,FOXO3 binds Rbl2 gene	yes	reactome/R-NUL-9620806.md	FOXO1,FOXO3 binds Rbl2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds Rbl2 gene.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	115	R-NUL-9620857	FOXO1,FOXO3 binds Ccng2 gene	yes	reactome/R-NUL-9620857.md	FOXO1,FOXO3 binds Ccng2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds Ccng2 gene.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	116	R-NUL-9624599	FOXO1 binds Fbxo32 gene promoter	yes	reactome/R-NUL-9624599.md	FOXO1 binds Fbxo32 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 binds Fbxo32 gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	117	R-NUL-9625492	FOXO1 and p-2S-Smad2/3:Smad4 bind Mstn gene promoter	yes	reactome/R-NUL-9625492.md	FOXO1 and p-2S-Smad2/3:Smad4 bind Mstn gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 and Smad2/3:Smad4 bind Mstn gene promoter.
human	FOXO1	genes/human/FOXO1/FOXO1-ai-review.yaml	FOXO1	Q12778	NCBITaxon:9606	Homo sapiens	118	R-NUL-9625758	FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter	yes	reactome/R-NUL-9625758.md	FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	FOXO1 and SMAD3 bind Trim63 gene promoter.
human	FTCD	genes/human/FTCD/FTCD-ai-review.yaml	FTCD	O95954	NCBITaxon:9606	Homo sapiens	32	R-HSA-70920	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate	yes	reactome/R-HSA-70920.md	N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome (traceable author statement) places the FTCD reaction in the cytosol (""Cytosolic formimidoyltransferase-cyclodeaminase""). Consistent with the primary catalytic localization."
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	43	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for neutrophil degranulation. Ferritin is found in neutrophil tertiary granules and can be released during degranulation.
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	44	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for neutrophil granule content. Similar to tertiary granule annotation.
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	49	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation related to neutrophil degranulation and secretion.
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	50	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate annotation for extracellular region from Reactome.
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	51	R-HSA-1562626	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)	yes	reactome/R-HSA-1562626.md	Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for ferritin complex oxidizing Fe2+ to Fe3+. Cytosolic localization is consistent with ferritin's primary function site.
human	FTH1	genes/human/FTH1/FTH1-ai-review.yaml	FTH1	P02794	NCBITaxon:9606	Homo sapiens	52	R-HSA-434362	Recruitment Of Cytoplasmic Proteins To Vesicles	yes	reactome/R-HSA-434362.md	Recruitment Of Cytoplasmic Proteins To Vesicles	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for recruitment of cytoplasmic proteins to vesicles.
human	FTO	genes/human/FTO/FTO-ai-review.yaml	FTO	Q9C0B1	NCBITaxon:9606	Homo sapiens	37	R-HSA-8857692	RNA demethylases demethylate N6-methyladenosine RNA	yes	reactome/R-HSA-8857692.md	RNA demethylases demethylate N6-methyladenosine RNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome placement of FTO in the nucleoplasm.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	27	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	yes	reactome/R-HSA-1362409.md	Mitochondrial iron-sulfur cluster biogenesis	Homo sapiens	GO:0016226	iron-sulfur cluster assembly	TAS	involved_in	BP	false		ACCEPT	Reactome annotation for mitochondrial iron-sulfur cluster biogenesis.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	28	R-HSA-9865881	Complex III assembly	yes	reactome/R-HSA-9865881.md	Complex III assembly	Homo sapiens	GO:0034551	mitochondrial respiratory chain complex III assembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	FXN contributes to Complex III assembly by providing Fe-S clusters. This is a downstream effect of its Fe-S cluster assembly function.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	31	R-HSA-1362416	Frataxin binds iron	yes	reactome/R-HSA-1362416.md	Frataxin binds iron	Homo sapiens	GO:0008198	ferrous iron binding	TAS	enables	MF	false		ACCEPT	Reactome annotation for frataxin binding iron.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	44	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0034986	iron chaperone activity	TAS	enables	MF	false		ACCEPT	Reactome annotation for iron chaperone function in cluster assembly.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	54	R-HSA-1362408	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	yes	reactome/R-HSA-1362408.md	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for mitochondrial matrix localization.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	55	R-HSA-1362416	Frataxin binds iron	yes	reactome/R-HSA-1362416.md	Frataxin binds iron	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	56	R-HSA-9854405	Frataxin transfers Fe2+ to ACO2	yes	reactome/R-HSA-9854405.md	Frataxin transfers Fe2+ to ACO2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for frataxin transferring Fe2+ to ACO2.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	57	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Fe-S cluster transfer to SDHB.
human	FXN	genes/human/FXN/FXN-ai-review.yaml	FXN	Q16595	NCBITaxon:9606	Homo sapiens	58	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for [2Fe-2S] insertion in UQCRFS1.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	35	R-HSA-3858482	Reactome pathway annotation	yes	reactome/R-HSA-3858482.md	DVL is recruited to the receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence above.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	53	R-HSA-9673284	Reactome pathway annotation	yes	reactome/R-HSA-9673284.md	GTP-bound RAC1 contributes to MAPK8 activation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	54	R-HSA-9673288	Reactome pathway annotation	yes	reactome/R-HSA-9673288.md	ppDVL binds RAC1:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	55	R-HSA-9673296	Reactome pathway annotation	yes	reactome/R-HSA-9673296.md	WNT5:FZD7 binds p-DVL	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	56	R-HSA-9673349	Reactome pathway annotation	yes	reactome/R-HSA-9673349.md	WNT5 binds FZD7	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	57	R-HSA-9673794	Reactome pathway annotation	yes	reactome/R-HSA-9673794.md	ppDVL:RAC1:GTP binds NOX1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	58	R-HSA-9673797	Reactome pathway annotation	yes	reactome/R-HSA-9673797.md	NOX1 complex:pp-DVL:RAC1:GTP generates superoxide from oxygen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZD7	genes/human/FZD7/FZD7-ai-review.yaml	FZD7	O75084	NCBITaxon:9606	Homo sapiens	59	R-NUL-1504194	Reactome pathway annotation	yes	reactome/R-NUL-1504194.md	mDvl1 binds FZD7	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Consolidated with IDA evidence.
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	35	R-HSA-174057	Multiubiquitination of APC/C-associated Cdh1	yes	reactome/R-HSA-174057.md	Multiubiquitination of APC/C-associated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Multiubiquitination of APC/C-associated Cdh1' (Reactome:R-HSA-174057) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	36	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Degradation of multiubiquitinated Cdh1' (Reactome:R-HSA-174058) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	37	R-HSA-174079	Phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-174079.md	Phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylation of Cdh1 by Cyclin A:Cdk2' (Reactome:R-HSA-174079) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	38	R-HSA-174097	Association of Emi1 with Cdh1	yes	reactome/R-HSA-174097.md	Association of Emi1 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Association of Emi1 with Cdh1' (Reactome:R-HSA-174097) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	39	R-HSA-174122	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	yes	reactome/R-HSA-174122.md	Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2' (Reactome:R-HSA-174122) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	40	R-HSA-174139	Dissociation of phospho-Cdh1 from the APC/C complex	yes	reactome/R-HSA-174139.md	Dissociation of phospho-Cdh1 from the APC/C complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Dissociation of phospho-Cdh1 from the APC/C complex' (Reactome:R-HSA-174139) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	41	R-HSA-174174	Phosphorylation of the Emi1 DSGxxS degron by Plk1	yes	reactome/R-HSA-174174.md	Phosphorylation of the Emi1 DSGxxS degron by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylation of the Emi1 DSGxxS degron by Plk1' (Reactome:R-HSA-174174) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	42	R-HSA-174251	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	yes	reactome/R-HSA-174251.md	Phosphorylation of Cdh1 by Cyclin B1:Cdc2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylation of Cdh1 by Cyclin B1:Cdc2' (Reactome:R-HSA-174251) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	43	R-HSA-187948	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2	yes	reactome/R-HSA-187948.md	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2' (Reactome:R-HSA-187948) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	44	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'APC/C:Cdh1-mediated degradation of Skp2' (Reactome:R-HSA-188191) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	45	R-HSA-188371	Association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-188371.md	Association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Association of Cyclin A:Cdk2 with Cdh1' (Reactome:R-HSA-188371) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	46	R-HSA-3788705	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	yes	reactome/R-HSA-3788705.md	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2' (Reactome:R-HSA-3788705) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	47	R-HSA-3788708	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	yes	reactome/R-HSA-3788708.md	CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1' (Reactome:R-HSA-3788708) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	48	R-HSA-3788724	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	yes	reactome/R-HSA-3788724.md	Cdh1:APC/C ubiquitinates EHMT1 and EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Cdh1:APC/C ubiquitinates EHMT1 and EHMT2' (Reactome:R-HSA-3788724) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	49	R-HSA-3788725	Cdh1:APC/C complex binds EHMT1:EHMT2	yes	reactome/R-HSA-3788725.md	Cdh1:APC/C complex binds EHMT1:EHMT2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Cdh1:APC/C complex binds EHMT1:EHMT2' (Reactome:R-HSA-3788725) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	50	R-HSA-68712	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	yes	reactome/R-HSA-68712.md	The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1' (Reactome:R-HSA-68712) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	51	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'APC/C:Cdh1 polyubiquitinates SKP2' (Reactome:R-HSA-9686969) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	52	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'RB1 recruits APC/C:Cdh1 complex to SKP2' (Reactome:R-HSA-9686980) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	53	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'Defective RB1 does not form a complex with SKP2 and FZR1' (Reactome:R-HSA-9687377) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	54	R-HSA-9929717	CCNA:CDK1 phosphorylates FZR1	yes	reactome/R-HSA-9929717.md	CCNA:CDK1 phosphorylates FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome event 'CCNA:CDK1 phosphorylates FZR1' (Reactome:R-HSA-9929717) places FZR1 in the nucleoplasm, where APC/C-Cdh1 assembles, is regulated by CDK phosphorylation/dephosphorylation and Emi1, and ubiquitinates nuclear substrates (SKP2, geminin, EHMT1/2, cyclins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	58	R-HSA-174070	Association of Cdh1 with the APC/C	yes	reactome/R-HSA-174070.md	Association of Cdh1 with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Association of Cdh1 with the APC/C' (Reactome:R-HSA-174070) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	59	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Association of cell cycle proteins with the APC/C:Cdh1 complex' (Reactome:R-HSA-174088) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	60	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Degradation of multiubiquitinated cell cycle proteins' (Reactome:R-HSA-174105) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	61	R-HSA-174124	Dephosphorylation of phospho-Cdh1	yes	reactome/R-HSA-174124.md	Dephosphorylation of phospho-Cdh1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Dephosphorylation of phospho-Cdh1' (Reactome:R-HSA-174124) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	62	R-HSA-174159	Ubiquitination of Emi1 by SCF-beta-TrCP	yes	reactome/R-HSA-174159.md	Ubiquitination of Emi1 by SCF-beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Ubiquitination of Emi1 by SCF-beta-TrCP' (Reactome:R-HSA-174159) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	63	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex' (Reactome:R-HSA-174195) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	64	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'SCF-mediated degradation of Emi1' (Reactome:R-HSA-174203) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	65	R-HSA-174209	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	yes	reactome/R-HSA-174209.md	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Phosphorylated Emi1 binds the beta-TrCP in the SCF complex' (Reactome:R-HSA-174209) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	FZR1	genes/human/FZR1/FZR1-ai-review.yaml	FZR1	Q9UM11	NCBITaxon:9606	Homo sapiens	66	R-HSA-69015	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	yes	reactome/R-HSA-69015.md	Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event 'Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex' (Reactome:R-HSA-69015) places FZR1 in the cytosol, reflecting cytosolic APC/C-Cdh1 events (association with APC/C, Emi1 phosphorylation/degradation, ubiquitination of cytoplasmic CDC6 and other cell-cycle proteins).
human	G6PC1	genes/human/G6PC1/G6PC1-ai-review.yaml	G6PC1	P35575	NCBITaxon:9606	Homo sapiens	20	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assignment placing G6PC1 in gluconeogenesis, where it catalyzes the terminal hydrolysis of glucose-6-phosphate to glucose. Core.
human	G6PC1	genes/human/G6PC1/G6PC1-ai-review.yaml	G6PC1	P35575	NCBITaxon:9606	Homo sapiens	22	R-HSA-3274540	Defective G6PC does not hydrolyze glucose 6-phosphate	no				GO:0004346	glucose-6-phosphatase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assignment of glucose-6-phosphatase activity (in the context of loss-of-function disease variants). Consistent with the core function.
human	G6PC1	genes/human/G6PC1/G6PC1-ai-review.yaml	G6PC1	P35575	NCBITaxon:9606	Homo sapiens	28	R-HSA-3274540	Defective G6PC does not hydrolyze glucose 6-phosphate	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of ER membrane localization. Consistent with the experimentally established core location.
human	G6PC1	genes/human/G6PC1/G6PC1-ai-review.yaml	G6PC1	P35575	NCBITaxon:9606	Homo sapiens	29	R-HSA-71825	G6PC hydrolyzes G6P to Glc and Pi (liver)	yes	reactome/R-HSA-71825.md	G6PC hydrolyzes G6P to Glc and Pi (liver)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment (liver G6P hydrolysis reaction) placing G6PC1 at the ER membrane. Core location.
human	G6PC1	genes/human/G6PC1/G6PC1-ai-review.yaml	G6PC1	P35575	NCBITaxon:9606	Homo sapiens	30	R-HSA-9944724	TCF19:NuRD represses G6PC gene expression	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment associated with a gene-regulation event (TCF19:NuRD repression); the localization to the ER membrane is correct for the encoded protein. Core location.
human	G6PC3	genes/human/G6PC3/G6PC3-ai-review.yaml	G6PC3	Q9BUM1	NCBITaxon:9606	Homo sapiens	10	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway (Gluconeogenesis) traceable assignment placing G6PC3 in the gluconeogenesis pathway.
human	G6PC3	genes/human/G6PC3/G6PC3-ai-review.yaml	G6PC3	Q9BUM1	NCBITaxon:9606	Homo sapiens	12	R-HSA-3282876	Defective G6PC3 does not hydrolyze glucose 6-phosphate	no				GO:0004346	glucose-6-phosphatase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assignment of glucose-6-phosphatase activity (context: defective G6PC3 does not hydrolyze G6P), consistent with the core function.
human	G6PC3	genes/human/G6PC3/G6PC3-ai-review.yaml	G6PC3	Q9BUM1	NCBITaxon:9606	Homo sapiens	16	R-HSA-3282876	Defective G6PC3 does not hydrolyze glucose 6-phosphate	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of ER membrane localization for G6PC3.
human	G6PC3	genes/human/G6PC3/G6PC3-ai-review.yaml	G6PC3	Q9BUM1	NCBITaxon:9606	Homo sapiens	17	R-HSA-3262512	G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)	yes	reactome/R-HSA-3262512.md	G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of ER membrane localization (reaction: G6PC3 hydrolyzes G6P to form Glc and Pi, ubiquitous).
human	G6PD	genes/human/G6PD/G6PD-ai-review.yaml	G6PD	P11413	NCBITaxon:9606	Homo sapiens	44	R-HSA-70377	G6PD multimers dehydrogenate G6P	yes	reactome/R-HSA-70377.md	G6PD multimers dehydrogenate G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the G6PD dehydrogenation reaction (G6PD multimers dehydrogenate G6P) in the cytosol.
human	G6PD	genes/human/G6PD/G6PD-ai-review.yaml	G6PD	P11413	NCBITaxon:9606	Homo sapiens	45	R-HSA-9761849	AcK-NFE2L2-dependent P6GD gene expression	yes	reactome/R-HSA-9761849.md	AcK-NFE2L2-dependent P6GD gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion for cytosolic localization associated with an NRF2/NFE2L2-dependent G6PD expression event.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	15	R-HSA-70221	Glycogen breakdown (glycogenolysis)	yes	reactome/R-HSA-70221.md	Glycogen breakdown (glycogenolysis)	Homo sapiens	GO:0005980	glycogen catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing GAA in glycogen breakdown (glycogenolysis), specifically the lysosomal glycogen degradation reaction.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	20	R-HSA-9036729	Defective GAA does not hydrolyze lysosomal glycogen	no				GO:0090599	alpha-glucosidase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome traceable assertion of alpha-glucosidase activity (in the module describing defective GAA that does not hydrolyse lysosomal glycogen).
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	26	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane localization asserted via Reactome neutrophil-degranulation (azurophil granule exocytosis) pathway.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane localization asserted via Reactome neutrophil-degranulation (tertiary granule exocytosis) pathway.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	28	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma-membrane localization asserted via Reactome neutrophil-degranulation (ficolin-rich granule exocytosis) pathway.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Localization to azurophil (primary) granule membrane via Reactome neutrophil-degranulation curation.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Localization to tertiary granule membrane via Reactome neutrophil-degranulation curation.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	31	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Localization to ficolin-1-rich granule membrane via Reactome neutrophil-degranulation curation.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	34	R-HSA-9036729	Defective GAA does not hydrolyze lysosomal glycogen	no				GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing mature GAA in the lysosomal lumen.
human	GAA	genes/human/GAA/GAA-ai-review.yaml	GAA	P10253	NCBITaxon:9606	Homo sapiens	35	R-HSA-9036727	GAA hydrolyzes lysosomal glycogen	yes	reactome/R-HSA-9036727.md	GAA hydrolyzes lysosomal glycogen	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (GAA hydrolyzes lysosomal glycogen module) placing GAA in the lysosomal lumen.
human	GAD1	genes/human/GAD1/GAD1-ai-review.yaml	GAD1	Q99259	NCBITaxon:9606	Homo sapiens	21	R-HSA-888589	Release of GABA at the synapse	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) localization to the plasma membrane, derived from a GABA-release-at-the-synapse pathway context. GAD67 is a soluble cytosolic enzyme and does not itself reside in the plasma membrane.
human	GAD1	genes/human/GAD1/GAD1-ai-review.yaml	GAD1	Q99259	NCBITaxon:9606	Homo sapiens	22	R-HSA-888572	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA	yes	reactome/R-HSA-888572.md	PXLP-K405-GAD1 decarboxylates L-Glu to form GABA	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) localization to the clathrin-sculpted GABA transport vesicle membrane, a GABA-synthesis/vesicle-loading pathway context. GAD67 is a soluble cytosolic enzyme rather than an integral/peripheral vesicle-membrane protein.
human	GAD1	genes/human/GAD1/GAD1-ai-review.yaml	GAD1	Q99259	NCBITaxon:9606	Homo sapiens	23	R-HSA-888577	Synthesis of GABA by GAD2	yes	reactome/R-HSA-888577.md	Synthesis of GABA by GAD2	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) localization to the clathrin-sculpted GABA transport vesicle membrane (duplicate pathway-context annotation, from the GAD2 GABA-synthesis reaction). GAD67 is cytosolic.
human	GAD1	genes/human/GAD1/GAD1-ai-review.yaml	GAD1	Q99259	NCBITaxon:9606	Homo sapiens	24	R-HSA-888589	Release of GABA at the synapse	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) localization to the clathrin-sculpted GABA transport vesicle membrane (duplicate pathway-context annotation, from the GABA-release reaction). GAD67 is cytosolic.
human	GAD1	genes/human/GAD1/GAD1-ai-review.yaml	GAD1	Q99259	NCBITaxon:9606	Homo sapiens	25	R-HSA-917744	GABA loaded synaptic vesicle Docking and Priming	yes	reactome/R-HSA-917744.md	GABA loaded synaptic vesicle Docking and Priming	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) localization to the clathrin-sculpted GABA transport vesicle membrane (duplicate pathway-context annotation, from the vesicle docking/priming reaction). GAD67 is cytosolic.
human	GADD45A	genes/human/GADD45A/GADD45A-ai-review.yaml	GADD45A	P24522	NCBITaxon:9606	Homo sapiens	39	R-HSA-3215144	TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription	yes	reactome/R-HSA-3215144.md	TP53 in complex with EP300, PRMT1 and CARM1 stimulates GADD45A transcription	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for p53-mediated GADD45A transcription. Nucleoplasm localization is consistent with GADD45A nuclear function and its role in PCNA and Aurora A binding within the nucleus.
human	GADD45A	genes/human/GADD45A/GADD45A-ai-review.yaml	GADD45A	P24522	NCBITaxon:9606	Homo sapiens	40	R-HSA-6791109	GADD45A binds PCNA	yes	reactome/R-HSA-6791109.md	GADD45A binds PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GADD45A-PCNA binding. Nucleoplasm is appropriate as GADD45A interacts with PCNA at sites of DNA replication/repair in the nuclear compartment.
human	GADD45A	genes/human/GADD45A/GADD45A-ai-review.yaml	GADD45A	P24522	NCBITaxon:9606	Homo sapiens	41	R-HSA-6791235	GADD45A binds AURKA	yes	reactome/R-HSA-6791235.md	GADD45A binds AURKA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GADD45A-AURKA binding. GADD45A binds Aurora A kinase through its dimerization interface, regulating centrosome function. Nucleoplasm localization is appropriate.
human	GADD45A	genes/human/GADD45A/GADD45A-ai-review.yaml	GADD45A	P24522	NCBITaxon:9606	Homo sapiens	42	R-NUL-9617912	FOXO-mediated transcription of cell cycle genes	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. Nucleoplasm localization is consistent with multiple lines of evidence for nuclear GADD45A function. Multiple redundant annotations for same CC term.
human	GAL3ST1	genes/human/GAL3ST1/GAL3ST1-ai-review.yaml	GAL3ST1	Q99999	NCBITaxon:9606	Homo sapiens	10	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome places GAL3ST1 in glycosphingolipid biosynthesis.
human	GAL3ST1	genes/human/GAL3ST1/GAL3ST1-ai-review.yaml	GAL3ST1	Q99999	NCBITaxon:9606	Homo sapiens	12	R-HSA-9844587	GAL3ST1 transfers sulfate to GalCer,LacCer	yes	reactome/R-HSA-9844587.md	GAL3ST1 transfers sulfate to GalCer,LacCer	Homo sapiens	GO:0001733	galactosylceramide sulfotransferase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'GAL3ST1 transfers sulfate to GalCer,LacCer'.
human	GAL3ST1	genes/human/GAL3ST1/GAL3ST1-ai-review.yaml	GAL3ST1	Q99999	NCBITaxon:9606	Homo sapiens	19	R-HSA-9844587	GAL3ST1 transfers sulfate to GalCer,LacCer	yes	reactome/R-HSA-9844587.md	GAL3ST1 transfers sulfate to GalCer,LacCer	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the GAL3ST1 reaction at the Golgi membrane.
human	GALC	genes/human/GALC/GALC-ai-review.yaml	GALC	P54803	NCBITaxon:9606	Homo sapiens	12	R-HSA-9840310	Glycosphingolipid catabolism	yes	reactome/R-HSA-9840310.md	Glycosphingolipid catabolism	Homo sapiens	GO:0046479	glycosphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing GALC in glycosphingolipid catabolism. Galactosylceramide is a glycosphingolipid, so this is a correct but broader-than-precise parent process relative to galactosylceramide catabolic process.
human	GALC	genes/human/GALC/GALC-ai-review.yaml	GALC	P54803	NCBITaxon:9606	Homo sapiens	14	R-HSA-1606564	GALC hydrolyzes GalCer	yes	reactome/R-HSA-1606564.md	GALC hydrolyzes GalCer	Homo sapiens	GO:0004336	galactosylceramidase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable assertion of galactosylceramidase activity (reaction ""GALC hydrolyzes GalCer""), matching the defining, experimentally verified core molecular function of GALC."
human	GALC	genes/human/GALC/GALC-ai-review.yaml	GALC	P54803	NCBITaxon:9606	Homo sapiens	19	R-HSA-1606564	GALC hydrolyzes GalCer	yes	reactome/R-HSA-1606564.md	GALC hydrolyzes GalCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion localizing GALC to the lysosomal lumen, the compartment where the soluble acid hydrolase acts on its substrate.
human	GALE	genes/human/GALE/GALE-ai-review.yaml	GALE	Q14376	NCBITaxon:9606	Homo sapiens	13	R-HSA-5610036	Defective GALE does not epimerise UDP-Gal to UDP-Glc	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing GALE to the cytosol, in the context of defective GALE failing to epimerise UDP-Gal to UDP-Glc. Consistent with the other cytosol annotations.
human	GALE	genes/human/GALE/GALE-ai-review.yaml	GALE	Q14376	NCBITaxon:9606	Homo sapiens	14	R-HSA-70369	GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the GALE:NAD+ dimer epimerization reaction in the cytosol. Directly supports the cytosolic localization of the active enzyme.
human	GALK1	genes/human/GALK1/GALK1-ai-review.yaml	GALK1	P51570	NCBITaxon:9606	Homo sapiens	13	R-HSA-70370	Galactose catabolism	no				GO:0033499	beta-D-galactose catabolic process via UDP-galactose, Leloir pathway	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) assertion of Leloir-pathway galactose catabolism, corroborating the IEA annotation of the same term.
human	GALK1	genes/human/GALK1/GALK1-ai-review.yaml	GALK1	P51570	NCBITaxon:9606	Homo sapiens	15	R-HSA-5610026	Defective GALK1 does not phosphorylate Gal	no				GO:0004335	galactokinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of galactokinase activity, corroborating the experimental annotations.
human	GALK1	genes/human/GALK1/GALK1-ai-review.yaml	GALK1	P51570	NCBITaxon:9606	Homo sapiens	16	R-HSA-5610026	Defective GALK1 does not phosphorylate Gal	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization, matching the experimentally determined cytosolic localization.
human	GALK1	genes/human/GALK1/GALK1-ai-review.yaml	GALK1	P51570	NCBITaxon:9606	Homo sapiens	19	R-HSA-70355	GALK1 phosphorylates Gal to Gal1P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) cytosol localization from the ""GALK1 phosphorylates Gal to Gal1P"" reaction, matching experimental cytosolic localization."
human	GALM	genes/human/GALM/GALM-ai-review.yaml	GALM	Q96C23	NCBITaxon:9606	Homo sapiens	10	R-HSA-70370	Galactose catabolism	no				GO:0033499	beta-D-galactose catabolic process via UDP-galactose, Leloir pathway	TAS	involved_in	BP	false		ACCEPT	Reactome-curated (TAS) assignment of GALM to the Leloir pathway of galactose catabolism.
human	GALM	genes/human/GALM/GALM-ai-review.yaml	GALM	Q96C23	NCBITaxon:9606	Homo sapiens	13	R-HSA-9931926	Defective GALM doesn't convert beta-D-GAL to alpha-D-GAL	no				GO:0004034	aldose 1-epimerase activity	TAS	enables	MF	false		ACCEPT	Reactome-curated (TAS) assertion of aldose 1-epimerase activity (in the context of the defective-GALM reaction).
human	GALM	genes/human/GALM/GALM-ai-review.yaml	GALM	Q96C23	NCBITaxon:9606	Homo sapiens	14	R-HSA-9931853	GALM converts beta-D-GAL to alpha-D-GAL	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-curated (TAS) localization of GALM (the ""GALM converts beta-D-GAL to alpha-D-GAL"" reaction) to the cytosol."
human	GALM	genes/human/GALM/GALM-ai-review.yaml	GALM	Q96C23	NCBITaxon:9606	Homo sapiens	15	R-HSA-9931926	Defective GALM doesn't convert beta-D-GAL to alpha-D-GAL	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) cytosol localization (defective-GALM reaction context). Duplicate of the preceding cytosol annotation from a related Reactome reaction.
human	GALNS	genes/human/GALNS/GALNS-ai-review.yaml	GALNS	P34059	NCBITaxon:9606	Homo sapiens	4	R-HSA-2263490	Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate	yes	reactome/R-HSA-2263490.md	Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate	Homo sapiens	GO:0043890	N-acetylgalactosamine-6-sulfatase activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted core molecular function (6-sulfatase acting on Gal6S/GalNAc6S in keratan sulfate and chondroitin sulfate).
human	GALNS	genes/human/GALNS/GALNS-ai-review.yaml	GALNS	P34059	NCBITaxon:9606	Homo sapiens	9	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular localisation asserted via Reactome neutrophil-degranulation / azurophil-granule exocytosis pathway. A secreted-fraction localisation, not the primary site of GALNS action.
human	GALNS	genes/human/GALNS/GALNS-ai-review.yaml	GALNS	P34059	NCBITaxon:9606	Homo sapiens	10	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Localisation to the azurophil (primary) granule lumen of neutrophils, asserted via the Reactome neutrophil-degranulation pathway.
human	GALNS	genes/human/GALNS/GALNS-ai-review.yaml	GALNS	P34059	NCBITaxon:9606	Homo sapiens	11	R-HSA-2263490	Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate	yes	reactome/R-HSA-2263490.md	Defective GALNS does not hydrolyse sulfate from Gal6S in keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Localisation to the lysosomal lumen, the precise compartment where GALNS acts on keratan sulfate and chondroitin-6-sulfate.
human	GALNS	genes/human/GALNS/GALNS-ai-review.yaml	GALNS	P34059	NCBITaxon:9606	Homo sapiens	13	R-HSA-1630304	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate	yes	reactome/R-HSA-1630304.md	GALNS oligomer hydrolyses sulfate from Gal6S in keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal-lumen localisation asserted by Reactome for the GALNS keratan-sulfate desulfation reaction; the precise site of GALNS catalysis.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	1	R-HSA-8849348	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo	yes	reactome/R-HSA-8849348.md	RAB6:GTP and BICD homodimers bind COPI-independent Golgi-to-ER retrograde cargo	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the functional location of GALNT1. UniProt records it specifically as a Golgi stack membrane, single-pass type II membrane protein, and the enzyme initiates O-glycosylation throughout the Golgi apparatus.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	2	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the functional location of GALNT1. UniProt records it specifically as a Golgi stack membrane, single-pass type II membrane protein, and the enzyme initiates O-glycosylation throughout the Golgi apparatus.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	3	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the functional location of GALNT1. UniProt records it specifically as a Golgi stack membrane, single-pass type II membrane protein, and the enzyme initiates O-glycosylation throughout the Golgi apparatus.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	4	R-HSA-913675	GALNTs transfer GalNAc to Mucins to form Tn antigens	yes	reactome/R-HSA-913675.md	GALNTs transfer GalNAc to Mucins to form Tn antigens	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane is the functional location of GALNT1. UniProt records it specifically as a Golgi stack membrane, single-pass type II membrane protein, and the enzyme initiates O-glycosylation throughout the Golgi apparatus.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	12	R-HSA-913675	GALNTs transfer GalNAc to Mucins to form Tn antigens	yes	reactome/R-HSA-913675.md	GALNTs transfer GalNAc to Mucins to form Tn antigens	Homo sapiens	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome's statement of GalNAc transfer, in the mucin Tn-antigen reaction and in the SARS-CoV-2 protein 3a glycosylation reaction respectively.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	13	R-HSA-9683760	GalNAc is transferred onto 3a	yes	reactome/R-HSA-9683760.md	GalNAc is transferred onto 3a	Homo sapiens	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome's statement of GalNAc transfer, in the mucin Tn-antigen reaction and in the SARS-CoV-2 protein 3a glycosylation reaction respectively.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	15	R-HSA-8849353	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	yes	reactome/R-HSA-8849353.md	Dynein drives COPI-independent retrograde traffic from the Golgi to the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This row comes from the Reactome reaction 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER', in which GALNT1 appears as retrograde cargo. It records a compartment the protein passes into during retrograde transport, not the compartment in which it does its work.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	24	R-HSA-913709	O-linked glycosylation of mucins	yes	reactome/R-HSA-913709.md	O-linked glycosylation of mucins	Homo sapiens	GO:0016266	protein O-linked glycosylation via N-acetylgalactosamine	TAS	involved_in	BP	false		ACCEPT	Reactome's 'O-linked glycosylation of mucins' pathway statement.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	25	R-HSA-9683673	Maturation of protein 3a	yes	reactome/R-HSA-9683673.md	Maturation of protein 3a	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	This row derives from the Reactome reaction 'Maturation of protein 3a', part of the SARS-CoV-2 infection pathway, in which GALNT1 O-glycosylates the viral ORF3a protein. The underlying fact is that a host glycosyltransferase modifies a viral substrate.
human	GALNT1	genes/human/GALNT1/GALNT1-ai-review.yaml	GALNT1	Q10472	NCBITaxon:9606	Homo sapiens	28	R-HSA-9683760	GalNAc is transferred onto 3a	yes	reactome/R-HSA-9683760.md	GalNAc is transferred onto 3a	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	From the Reactome reaction 'GalNAc is transferred onto 3a', part of the SARS-CoV-2 pathway, which models GALNT1 acting on the viral ORF3a protein in the ER-Golgi intermediate compartment.
human	GALT	genes/human/GALT/GALT-ai-review.yaml	GALT	P07902	NCBITaxon:9606	Homo sapiens	14	R-HSA-70370	Galactose catabolism	no				GO:0033499	beta-D-galactose catabolic process via UDP-galactose, Leloir pathway	TAS	involved_in	BP	false		ACCEPT	Core biological process, curated by Reactome as part of galactose catabolism. Duplicates the IBA call for the same specific Leloir-pathway term.
human	GALT	genes/human/GALT/GALT-ai-review.yaml	GALT	P07902	NCBITaxon:9606	Homo sapiens	16	R-HSA-5610038	Defective GALT does not transfer UMP to Gal1P	no				GO:0008108	UDP-glucose:hexose-1-phosphate uridylyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the (defective) GALT uridylyl-transfer reaction; supports the same core molecular function.
human	GALT	genes/human/GALT/GALT-ai-review.yaml	GALT	P07902	NCBITaxon:9606	Homo sapiens	22	R-HSA-5610038	Defective GALT does not transfer UMP to Gal1P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct subcellular localization. GALT is a soluble cytosolic Leloir enzyme; Reactome curates it in the cytosol.
human	GALT	genes/human/GALT/GALT-ai-review.yaml	GALT	P07902	NCBITaxon:9606	Homo sapiens	23	R-HSA-70361	GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct cytosolic localization (duplicate Reactome curation for the forward GALT reaction).
human	GAMT	genes/human/GAMT/GAMT-ai-review.yaml	GAMT	Q14353	NCBITaxon:9606	Homo sapiens	9	R-HSA-71288	Creatine metabolism	yes	reactome/R-HSA-71288.md	Creatine metabolism	Homo sapiens	GO:0006600	creatine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Creatine metabolic process is correct but is the broader parent of the more specific and better-supported 'creatine biosynthetic process'. Kept as non-core.
human	GAMT	genes/human/GAMT/GAMT-ai-review.yaml	GAMT	Q14353	NCBITaxon:9606	Homo sapiens	11	R-HSA-71286	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine	yes	reactome/R-HSA-71286.md	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine	Homo sapiens	GO:0008168	methyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Generic methyltransferase activity is correct but is a broad parent of the specific guanidinoacetate N-methyltransferase activity that is separately annotated.
human	GAMT	genes/human/GAMT/GAMT-ai-review.yaml	GAMT	Q14353	NCBITaxon:9606	Homo sapiens	12	R-HSA-71286	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine	yes	reactome/R-HSA-71286.md	guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is the supported subcellular localization of this soluble metabolic enzyme; the creatine-synthesis reaction is curated in the cytosol. Kept as non-core localization.
human	GAPDH	genes/human/GAPDH/GAPDH-ai-review.yaml	GAPDH	P04406	NCBITaxon:9606	Homo sapiens	78	R-HSA-70449	GADPH tetramer dehydrogenates GA3P	yes	reactome/R-HSA-70449.md	GADPH tetramer dehydrogenates GA3P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol annotation for GAPDH.
human	GAPDH	genes/human/GAPDH/GAPDH-ai-review.yaml	GAPDH	P04406	NCBITaxon:9606	Homo sapiens	79	R-HSA-70482	GAPDH tetramers reduce 1,3BPG to GA3P	yes	reactome/R-HSA-70482.md	GAPDH tetramers reduce 1,3BPG to GA3P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol annotation for GAPDH.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	21	R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	yes	reactome/R-HSA-73817.md	Purine ribonucleoside monophosphate biosynthesis	Homo sapiens	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-asserted involvement in purine ribonucleoside monophosphate (IMP) biosynthesis; the pathway assembles IMP on PRPP, and GART catalyzes three of its steps.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	22	R-HSA-73814	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi	yes	reactome/R-HSA-73814.md	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi	Homo sapiens	GO:0004637	phosphoribosylamine-glycine ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of GAR synthetase activity: synthesis of GAR from 5-phosphoribosylamine, glycine and ATP. A core catalytic activity.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	23	R-HSA-73810	FGAM + ATP => AIR + ADP + Pi	yes	reactome/R-HSA-73810.md	FGAM + ATP => AIR + ADP + Pi	Homo sapiens	GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of AIR synthetase activity: irreversible ATP-dependent synthesis of AIR from FGAM. A core catalytic activity.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	24	R-HSA-73813	GAR + 10-Formyl-THF => FGAR + THF	yes	reactome/R-HSA-73813.md	GAR + 10-Formyl-THF => FGAR + THF	Homo sapiens	GO:0004644	phosphoribosylglycinamide formyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of GAR transformylase activity: folate-dependent formyl transfer from 10-formyl-THF to GAR to give FGAR. A core catalytic activity.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	40	R-HSA-73810	FGAM + ATP => AIR + ADP + Pi	yes	reactome/R-HSA-73810.md	FGAM + ATP => AIR + ADP + Pi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the AIR synthetase reaction; the core location of GART.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	41	R-HSA-73813	GAR + 10-Formyl-THF => FGAR + THF	yes	reactome/R-HSA-73813.md	GAR + 10-Formyl-THF => FGAR + THF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the GAR transformylase reaction; the core location of GART.
human	GART	genes/human/GART/GART-ai-review.yaml	GART	P22102	NCBITaxon:9606	Homo sapiens	42	R-HSA-73814	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi	yes	reactome/R-HSA-73814.md	5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the GAR synthetase reaction; the core location of GART.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	27	R-HSA-202710	MERTK receptor binds ligands (Gas6 or Protein S)	yes	reactome/R-HSA-202710.md	MERTK receptor binds ligands (Gas6 or Protein S)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region is supported by GAS6 secretion and extracellular receptor-ligand activity.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	28	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region is supported by GAS6 secretion and extracellular receptor-ligand activity.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	29	R-HSA-163809	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus	yes	reactome/R-HSA-163809.md	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is compatible with GAS6 secretion, maturation, storage, or extracellular-vesicle association but is secondary to extracellular TAM receptor activation.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	30	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is compatible with GAS6 secretion, maturation, storage, or extracellular-vesicle association but is secondary to extracellular TAM receptor activation.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	31	R-HSA-163809	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus	yes	reactome/R-HSA-163809.md	Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to the Golgi apparatus	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is compatible with GAS6 secretion, maturation, storage, or extracellular-vesicle association but is secondary to extracellular TAM receptor activation.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	32	R-HSA-163843	Furin cleaves pro-GAS6 to GAS6	yes	reactome/R-HSA-163843.md	Furin cleaves pro-GAS6 to GAS6	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is compatible with GAS6 secretion, maturation, storage, or extracellular-vesicle association but is secondary to extracellular TAM receptor activation.
human	GAS6	genes/human/GAS6/GAS6-ai-review.yaml	GAS6	Q14393	NCBITaxon:9606	Homo sapiens	33	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	platelet alpha granule lumen is compatible with GAS6 secretion, maturation, storage, or extracellular-vesicle association but is secondary to extracellular TAM receptor activation.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	214	R-HSA-6783177	USP21 deubiquitinates GATA3,IL33	yes	reactome/R-HSA-6783177.md	USP21 deubiquitinates GATA3,IL33	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 localizes to the nucleoplasm.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	216	R-HSA-6793975	Expression of GATA3	yes	reactome/R-HSA-6793975.md	Expression of GATA3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	217	R-HSA-8956568	RUNX1 binds the core TAL1 complex	yes	reactome/R-HSA-8956568.md	RUNX1 binds the core TAL1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	218	R-HSA-8956586	RUNX1-containing TAL1 complex binds the MYB gene enhancer	yes	reactome/R-HSA-8956586.md	RUNX1-containing TAL1 complex binds the MYB gene enhancer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	219	R-HSA-9009065	FOXA1 and GATA3 bind to CCND1 promoter	yes	reactome/R-HSA-9009065.md	FOXA1 and GATA3 bind to CCND1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	220	R-HSA-9009371	Binding of AP1 transcriptional activator complexes to CCND1 promoter	yes	reactome/R-HSA-9009371.md	Binding of AP1 transcriptional activator complexes to CCND1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	221	R-HSA-9009526	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene	yes	reactome/R-HSA-9009526.md	CARM1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	222	R-HSA-9009533	TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter	yes	reactome/R-HSA-9009533.md	TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	223	R-HSA-9009536	DDX5 binds ESR1:estrogen:TFF1 gene promoter	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	224	R-HSA-9009541	ESR1 binds to TFF1 gene promoter	yes	reactome/R-HSA-9009541.md	ESR1 binds to TFF1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	225	R-HSA-9018494	FOXA1 and GATA3 bind TFF genes	yes	reactome/R-HSA-9018494.md	FOXA1 and GATA3 bind TFF genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	226	R-HSA-9018499	ESR1:ESTG and EP300 are recruited to TFF3 promoter	yes	reactome/R-HSA-9018499.md	ESR1:ESTG and EP300 are recruited to TFF3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	227	R-HSA-9023860	Histone acetyltransferases are recruited to the TFF1 gene	yes	reactome/R-HSA-9023860.md	Histone acetyltransferases are recruited to the TFF1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	228	R-HSA-9023861	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene	yes	reactome/R-HSA-9023861.md	PRMT1 binds TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	229	R-HSA-9038163	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators	yes	reactome/R-HSA-9038163.md	ESR1:ESTG:PGR:P4 bind pioneer factors and coactivators	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATA3	genes/human/GATA3/GATA3-ai-review.yaml	GATA3	P23771	NCBITaxon:9606	Homo sapiens	230	R-HSA-996755	ZFPM proteins bind GATA proteins	yes	reactome/R-HSA-996755.md	ZFPM proteins bind GATA proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GATA3 nucleoplasm localization from Reactome.
human	GATM	genes/human/GATM/GATM-ai-review.yaml	GATM	P50440	NCBITaxon:9606	Homo sapiens	12	R-HSA-71275	Creatine metabolism	no				GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Mitochondrial intermembrane space localization asserted by Reactome (creatine metabolism pathway).
human	GBA	genes/human/GBA/GBA-ai-review.yaml	GBA	P04062	NCBITaxon:9606	Homo sapiens	45	R-HSA-1605591	GBA1:SAPC hydrolyzes GlcCer	yes	reactome/R-HSA-1605591.md	GBA1:SAPC hydrolyzes GlcCer	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (GBA1:SAPC hydrolyzes GlcCer) placing GBA at the lysosomal membrane, where it acts together with saposin C on membrane-inserted glucosylceramide.
human	GBA1	genes/human/GBA1/GBA1-ai-review.yaml	GBA1	P04062	NCBITaxon:9606	Homo sapiens	47	R-HSA-1605591	GBA1:SAPC hydrolyzes GlcCer	yes	reactome/R-HSA-1605591.md	GBA1:SAPC hydrolyzes GlcCer	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	lysosomal membrane is an appropriate core cellular location for GBA1 catalytic activity and/or the GCase-LIMP-2 transport complex.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	12	R-HSA-3322077	Glycogen synthesis	yes	reactome/R-HSA-3322077.md	Glycogen synthesis	Homo sapiens	GO:0005978	glycogen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation (Glycogen synthesis pathway) to glycogen biosynthetic process. GBE1 catalyzes the branch-formation reaction that is one of the three reactions unique to glycogen synthesis, making this a well-supported core process annotation.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	14	R-HSA-3878762	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	yes	reactome/R-HSA-3878762.md	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	Homo sapiens	GO:0003844	1,4-alpha-glucan branching enzyme activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation (from the GSD IV disease reaction, in which defective GBE1 fails to catalyze branch formation) to 1,4-alpha-glucan branching enzyme activity. Reinforces the core catalytic function via pathway knowledge.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	21	R-HSA-3322005	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	yes	reactome/R-HSA-3322005.md	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol, from a reaction modeling GBE1 branch formation on polyGlc-GYG1 complexed with GYS1-a. Consistent with the soluble cytosolic localization of GBE1 acting on cytosolic glycogen granules.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	22	R-HSA-3322016	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol, from a reaction modeling GBE1 branch formation on polyGlc-GYG2 complexed with GYS2-a (liver isozyme context). Consistent with GBE1's cytosolic localization.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	23	R-HSA-3322057	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol, from a reaction modeling GBE1 branch formation on polyGlc-GYG1 complexed with GYS1-b. Consistent with GBE1's cytosolic localization.
human	GBE1	genes/human/GBE1/GBE1-ai-review.yaml	GBE1	Q04446	NCBITaxon:9606	Homo sapiens	24	R-HSA-3878762	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	yes	reactome/R-HSA-3878762.md	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol, from the GSD IV disease reaction in which defective GBE1 fails to catalyze branch formation. Confirms the core cytosolic localization of the enzyme.
human	GCDH	genes/human/GCDH/GCDH-ai-review.yaml	GCDH	Q92947	NCBITaxon:9606	Homo sapiens	25	R-HSA-71046	glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the glutaryl-CoA dehydrogenase reaction in the mitochondrial matrix, catalysed by the GCDH homotetramer lacking its transit peptide. This is the precise, correct subcellular location.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	27	R-HSA-381676	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	yes	reactome/R-HSA-381676.md	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Homo sapiens	GO:0032024	positive regulation of insulin secretion	TAS	involved_in	BP	false		ACCEPT	GLP-1 stimulates insulin secretion (incretin effect). Correct; a more general parent of the glucose-dependent term GO:0035774 also annotated here. Core (GLP-1).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	30	R-HSA-381612	GLP1R binds GLP1	yes	reactome/R-HSA-381612.md	GLP1R binds GLP1	Homo sapiens	GO:0048018	receptor ligand activity	TAS	enables	MF	false		ACCEPT	"GLP-1 acts as the agonist ligand of GLP1R (Reactome reaction ""GLP1R binds GLP1""). Correct core molecular function."
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	31	R-HSA-381799	Synthesis of Preproglucagon in intestinal L cells	yes	reactome/R-HSA-381799.md	Synthesis of Preproglucagon in intestinal L cells	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Correct biosynthetic transit location: preproglucagon is synthesized and folded in the ER lumen of L-cells. Appropriate as a pathway/location annotation.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	32	R-HSA-421416	Proglucagon translocates from the ER Lumen to secretory granules	yes	reactome/R-HSA-421416.md	Proglucagon translocates from the ER Lumen to secretory granules	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen transit during biosynthesis/trafficking. Redundant with the other ER-lumen annotation; correct.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	33	R-HSA-421416	Proglucagon translocates from the ER Lumen to secretory granules	yes	reactome/R-HSA-421416.md	Proglucagon translocates from the ER Lumen to secretory granules	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Proglucagon and its products are stored in regulated secretory granules prior to exocytosis. Correct location.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	39	R-HSA-163625	Glucagon binds to Glucagon receptor	yes	reactome/R-HSA-163625.md	Glucagon binds to Glucagon receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct location (glucagon binding GCGR occurs in the extracellular space). One of many redundant Reactome reaction-level extracellular-region annotations.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	40	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Gs activation reaction).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	41	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Gq/11 activation reaction).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	42	R-HSA-744886	The Ligand:GPCR:Gs complex dissociates	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Ligand:GPCR:Gs dissociation).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	43	R-HSA-744887	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Gs binding reaction).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	44	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Gq binding reaction).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	45	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Ligand:GPCR:Gq dissociation).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	46	R-HSA-825631	Glucagon:GCGR mediates GTP-GDP exchange	yes	reactome/R-HSA-825631.md	Glucagon:GCGR mediates GTP-GDP exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (Glucagon:GCGR GTP-GDP exchange).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	47	R-HSA-381612	GLP1R binds GLP1	yes	reactome/R-HSA-381612.md	GLP1R binds GLP1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (GLP1R binds GLP1).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	48	R-HSA-383313	Glucagon-like Peptide 1 is secreted from intestinal L cells	yes	reactome/R-HSA-383313.md	Glucagon-like Peptide 1 is secreted from intestinal L cells	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct location: GLP-1 is secreted from intestinal L-cells into the extracellular space. Redundant with other extracellular-region annotations.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	49	R-HSA-9023632	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)	yes	reactome/R-HSA-9023632.md	DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (DPP4 hydrolysis of GLP-1).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	50	R-HSA-9023633	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)	yes	reactome/R-HSA-9023633.md	DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (DPP4 hydrolysis of GLP-1).
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	51	R-HSA-383313	Glucagon-like Peptide 1 is secreted from intestinal L cells	yes	reactome/R-HSA-383313.md	Glucagon-like Peptide 1 is secreted from intestinal L cells	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	GLP-1 is packaged in secretory granules prior to release. Correct location; redundant with the other secretory-granule-lumen annotation.
human	GCG	genes/human/GCG/GCG-ai-review.yaml	GCG	P01275	NCBITaxon:9606	Homo sapiens	52	R-HSA-420123	Glucagon-like receptor 2 binds GLP2	yes	reactome/R-HSA-420123.md	Glucagon-like receptor 2 binds GLP2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct but redundant Reactome extracellular-region annotation (GLP2R binds GLP2).
human	GCH1	genes/human/GCH1/GCH1-ai-review.yaml	GCH1	P30793	NCBITaxon:9606	Homo sapiens	38	R-HSA-1474146	GCH1 reduces GTP to dihydroneopterin triphosphate	yes	reactome/R-HSA-1474146.md	GCH1 reduces GTP to dihydroneopterin triphosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation places GCH1 in the cytosol where it catalyzes conversion of GTP to dihydroneopterin triphosphate.
human	GCH1	genes/human/GCH1/GCH1-ai-review.yaml	GCH1	P30793	NCBITaxon:9606	Homo sapiens	39	R-HSA-1474158	GCHFR binds to GCH1 and negatively regulates its activity	yes	reactome/R-HSA-1474158.md	GCHFR binds to GCH1 and negatively regulates its activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GCHFR binding to GCH1, which occurs in the cytosol.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	32	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation placing GCK in canonical glycolysis (the Glycolysis pathway). GCK catalyzes the committed first step of glucose catabolism via glycolysis.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	34	R-HSA-5621918	Defective GCK does not phosphorylate Glc to form G6P	yes	reactome/R-HSA-5621918.md	Defective GCK does not phosphorylate Glc to form G6P	Homo sapiens	GO:0004340	glucokinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation of glucokinase activity, from the reaction describing defective GCK failing to phosphorylate glucose to G6P. Correct core molecular function.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	35	R-HSA-70420	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	yes	reactome/R-HSA-70420.md	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	Homo sapiens	GO:0004340	glucokinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation of glucokinase activity, from the reaction in which HK1,2,3,GCK,HKDC1 phosphorylate glucose to form G6P. Correct core molecular function.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	60	R-HSA-5621918	Defective GCK does not phosphorylate Glc to form G6P	yes	reactome/R-HSA-5621918.md	Defective GCK does not phosphorylate Glc to form G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, consistent with the cytosolic location of active glucokinase.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	61	R-HSA-170796	NPC transports GCK1:GCKR from cytosol to nucleoplasm	yes	reactome/R-HSA-170796.md	NPC transports GCK1:GCKR from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of nucleoplasmic localization, from the reaction transporting the GCK1:GCKR complex from cytosol to nucleoplasm. Reflects the regulated nuclear sequestration of hepatic GCK bound to GCKR at low glucose.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	62	R-HSA-170810	nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)	yes	reactome/R-HSA-170810.md	nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of nucleoplasmic localization, from the reaction dissociating the nucleoplasmic GCK1:GCKR complex. Reflects regulated nuclear sequestration of hepatic GCK.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	63	R-HSA-170825	NPC exports GCK1 from nucleus	yes	reactome/R-HSA-170825.md	NPC exports GCK1 from nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of nucleoplasmic localization, from the reaction exporting GCK1 from the nucleus. Reflects the regulated nuclear/cytosolic shuttling of hepatic GCK.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	64	R-HSA-170796	NPC transports GCK1:GCKR from cytosol to nucleoplasm	yes	reactome/R-HSA-170796.md	NPC transports GCK1:GCKR from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the reaction transporting GCK1:GCKR from cytosol to nucleoplasm; the cytosol is the origin compartment for active glucokinase.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	65	R-HSA-170799	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)	yes	reactome/R-HSA-170799.md	cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the reaction describing the cytosolic GCK1:GKRP complex equilibrium.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	66	R-HSA-170824	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex	yes	reactome/R-HSA-170824.md	glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the reaction forming the GCK1:GKRP complex from cytosolic glucokinase and GKRP.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	67	R-HSA-170825	NPC exports GCK1 from nucleus	yes	reactome/R-HSA-170825.md	NPC exports GCK1 from nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the reaction exporting GCK1 from the nucleus back to the cytosol.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	68	R-HSA-5661474	Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm	yes	reactome/R-HSA-5661474.md	Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the (disease) reaction of defective nuclear pore transport of GCK1:GKRP; cytosol is the origin compartment.
human	GCK	genes/human/GCK/GCK-ai-review.yaml	GCK	P35557	NCBITaxon:9606	Homo sapiens	69	R-HSA-70420	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	yes	reactome/R-HSA-70420.md	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of cytosolic localization, from the reaction in which HK1,2,3,GCK,HKDC1 phosphorylate glucose to G6P in the cytosol.
human	GCLC	genes/human/GCLC/GCLC-ai-review.yaml	GCLC	P48506	NCBITaxon:9606	Homo sapiens	42	R-HSA-5602892	Defective GCLC does not ligate L-Glu to L-Cys	yes	reactome/R-HSA-5602892.md	Defective GCLC does not ligate L-Glu to L-Cys	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation placing GCLC in the cytosol where the GCL reaction occurs.
human	GCLC	genes/human/GCLC/GCLC-ai-review.yaml	GCLC	P48506	NCBITaxon:9606	Homo sapiens	43	R-HSA-174367	GCL ligates L-Glu to L-Cys	yes	reactome/R-HSA-174367.md	GCL ligates L-Glu to L-Cys	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for the GCL ligation reaction occurring in the cytosol.
human	GCLC	genes/human/GCLC/GCLC-ai-review.yaml	GCLC	P48506	NCBITaxon:9606	Homo sapiens	44	R-HSA-9760122	AcK-NFE2L2-dependent GCLC gene expression	yes	reactome/R-HSA-9760122.md	AcK-NFE2L2-dependent GCLC gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for NRF2-dependent GCLC expression, placing the gene product in the cytosol.
human	GCLM	genes/human/GCLM/GCLM-ai-review.yaml	GCLM	P48507	NCBITaxon:9606	Homo sapiens	32	R-HSA-174367	GCL ligates L-Glu to L-Cys	yes	reactome/R-HSA-174367.md	GCL ligates L-Glu to L-Cys	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GCL is a cytosolic enzyme; the GCL-catalyzed ligation of L-Glu to L-Cys is placed in the cytosol by Reactome. Correct subcellular location.
human	GCLM	genes/human/GCLM/GCLM-ai-review.yaml	GCLM	P48507	NCBITaxon:9606	Homo sapiens	33	R-HSA-5602892	Defective GCLC does not ligate L-Glu to L-Cys	yes	reactome/R-HSA-5602892.md	Defective GCLC does not ligate L-Glu to L-Cys	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome (defective-GCLC reaction context). Correct location; redundant with the other cytosol annotations.
human	GCLM	genes/human/GCLM/GCLM-ai-review.yaml	GCLM	P48507	NCBITaxon:9606	Homo sapiens	34	R-HSA-9760125	AcK-NFE2L2-dependent GCLM gene expression	yes	reactome/R-HSA-9760125.md	AcK-NFE2L2-dependent GCLM gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome (GCLM gene-expression context). Correct location; redundant with the other cytosol annotations.
human	GCNT1	genes/human/GCNT1/GCNT1-ai-review.yaml	GCNT1	Q02742	NCBITaxon:9606	Homo sapiens	3	R-HSA-914012	GCNT1 transfers GlcNAc to Core 1 glycoproteins forming Core 2 glycoproteins	yes	reactome/R-HSA-914012.md	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the core 2 branching reaction in the Golgi membrane, consistent with the experimental evidence.
human	GCNT1	genes/human/GCNT1/GCNT1-ai-review.yaml	GCNT1	Q02742	NCBITaxon:9606	Homo sapiens	7	R-HSA-914012	GCNT1 transfers GlcNAc to Core 1 glycoproteins forming Core 2 glycoproteins	yes	reactome/R-HSA-914012.md	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins	Homo sapiens	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome's statement of the core 2 branching reaction, matching the assayed activity.
human	GCNT1	genes/human/GCNT1/GCNT1-ai-review.yaml	GCNT1	Q02742	NCBITaxon:9606	Homo sapiens	16	R-HSA-913709	Termination of O-glycan biosynthesis	yes	reactome/R-HSA-913709.md	O-linked glycosylation of mucins	Homo sapiens	GO:0016266	protein O-linked glycosylation via N-acetylgalactosamine	TAS	involved_in	BP	false		ACCEPT	Reactome's placement of core 2 branching within mucin-type O-glycan biosynthesis.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	12	R-HSA-5693967	PXLP-K754-GLDC dimer decarboxylates Gly	yes	reactome/R-HSA-5693967.md	PXLP-K754-GLDC dimer decarboxylates Gly	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable localization to the mitochondrial matrix, where the P-protein step of glycine cleavage produces the aminomethyl-lipoyl-GCSH intermediate. Precise, core localization.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	13	R-HSA-5693977	AMT transfers NH2CH2 from GCSH:SAMDLL to THF	yes	reactome/R-HSA-5693977.md	AMT transfers NH2CH2 from GCSH:SAMDLL to THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization (T-protein step transferring the GCSH-bound aminomethyl group to tetrahydrofolate). Precise, core localization.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	16	R-HSA-5694018	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	yes	reactome/R-HSA-5694018.md	DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization (L-protein reoxidation of dihydrolipoyl-GCSH). Precise, core localization.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	17	R-HSA-6792572	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	yes	reactome/R-HSA-6792572.md	LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization associated with the lipoyl-transfer reaction from lipoyl-GCSH to DBT/DLST (moonlighting lipoylation role). Correct compartment.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	18	R-HSA-6793591	LIAS synthesizes lipoyl-GCSH	yes	reactome/R-HSA-6793591.md	LIAS synthesizes lipoyl-GCSH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization associated with LIAS synthesis of lipoyl-GCSH. Correct compartment.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	19	R-HSA-9858752	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT	yes	reactome/R-HSA-9858752.md	LIPT1 transfers lipoyl group from lipoyl-GCSH to DLAT	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization associated with the lipoyl-transfer reaction from lipoyl-GCSH to DLAT (moonlighting lipoylation role). Correct compartment.
human	GCSH	genes/human/GCSH/GCSH-ai-review.yaml	GCSH	P23434	NCBITaxon:9606	Homo sapiens	20	R-HSA-6793590	LIPT2 transfers octanoyl group to GCSH	yes	reactome/R-HSA-6793590.md	LIPT2 transfers octanoyl group to GCSH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-traceable matrix localization associated with the LIPT2 octanoyl-transfer reaction generating octanoyl-GCSH. Correct compartment.
human	GDA	genes/human/GDA/GDA-ai-review.yaml	GDA	Q9Y2T3	NCBITaxon:9606	Homo sapiens	12	R-HSA-74255	Guanine + H2O => Xanthine + NH4+	yes	reactome/R-HSA-74255.md	Guanine + H2O => Xanthine + NH4+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core location, curated by Reactome for the human guanine-deamination reaction. Consistent with the IBA cytosol annotation.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	34	R-HSA-191830	snRNP nuclear import and release	yes	reactome/R-HSA-191830.md	snRNP nuclear import and release	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	GEMIN5 has a nuclear gem-associated pool.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	45	R-HSA-191763	snRNP:Snurportin complex formation	yes	reactome/R-HSA-191763.md	snRNP:Snurportin complex formation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GEMIN5 acts in cytoplasmic RNA complexes.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	46	R-HSA-191784	snRNA Cap hypermethylation	yes	reactome/R-HSA-191784.md	snRNA Cap hypermethylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GEMIN5 acts in cytoplasmic RNA complexes.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	47	R-HSA-191786	snRNP complex assembly	yes	reactome/R-HSA-191786.md	snRNP complex assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GEMIN5 acts in cytoplasmic RNA complexes.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	48	R-HSA-191790	Loading and methylation of Sm proteins onto SMN Complexes	yes	reactome/R-HSA-191790.md	Loading and methylation of Sm proteins onto SMN Complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GEMIN5 acts in cytoplasmic RNA complexes.
human	GEMIN5	genes/human/GEMIN5/GEMIN5-ai-review.yaml	GEMIN5	Q8TEQ6	NCBITaxon:9606	Homo sapiens	49	R-HSA-191830	snRNP nuclear import and release	yes	reactome/R-HSA-191830.md	snRNP nuclear import and release	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	GEMIN5 acts in cytoplasmic RNA complexes.
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	13	R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	yes	reactome/R-HSA-446210.md	Synthesis of UDP-N-acetyl-glucosamine	Homo sapiens	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Core biological process, curated by Reactome (Synthesis of UDP-N-acetyl-glucosamine). GFPT1 catalyzes the first committed step of UDP-GlcNAc biosynthesis.
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	15	R-HSA-4085027	Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-4085027.md	Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0004360	L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity	TAS	enables	MF	false		ACCEPT	Core molecular function, curated by Reactome (this reaction annotation describes the defective-GFPT1 case but asserts the wild-type activity of transferring an amino group from L-Gln to F6P to form GlcN6P).
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	16	R-HSA-449715	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-449715.md	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0004360	L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity	TAS	enables	MF	false		ACCEPT	Core molecular function, curated by Reactome (GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P). Consistent with all other GO:0004360 annotations.
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	22	R-HSA-4085027	Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-4085027.md	Defective GFPT1 does not transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct subcellular localization. GFPT1 is a soluble cytosolic enzyme (no signal peptide or transmembrane region); the HBP is a cytosolic branch of glycolysis. Curated by Reactome.
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	25	R-HSA-1791088	Expression of GFPT1	yes	reactome/R-HSA-1791088.md	Expression of GFPT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization, curated by Reactome (Expression of GFPT1). Consistent with the other cytosol annotations.
human	GFPT1	genes/human/GFPT1/GFPT1-ai-review.yaml	GFPT1	Q06210	NCBITaxon:9606	Homo sapiens	26	R-HSA-449715	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-449715.md	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization, curated by Reactome (GFPT1,2 reaction). Consistent with the other cytosol annotations.
human	GFPT2	genes/human/GFPT2/GFPT2-ai-review.yaml	GFPT2	O94808	NCBITaxon:9606	Homo sapiens	13	R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	yes	reactome/R-HSA-446210.md	Synthesis of UDP-N-acetyl-glucosamine	Homo sapiens	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS placing GFAT2 in ""Synthesis of UDP-N-acetyl-glucosamine"". Correct core biological process; GFAT2 catalyzes the first step of this pathway."
human	GFPT2	genes/human/GFPT2/GFPT2-ai-review.yaml	GFPT2	O94808	NCBITaxon:9606	Homo sapiens	15	R-HSA-449715	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-449715.md	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0004360	L-glutamine:D-fructose-6-phosphate transaminase (isomerizing) activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the GFAT2 reaction ""GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P"". This is the core catalytic function; consistent with the experimental IDA and the EC 2.6.1.16 assignment."
human	GFPT2	genes/human/GFPT2/GFPT2-ai-review.yaml	GFPT2	O94808	NCBITaxon:9606	Homo sapiens	19	R-HSA-449715	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	yes	reactome/R-HSA-449715.md	GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the cytosol. HBP enzymes act in the cytosol and GFAT2 is a soluble metabolic enzyme with no predicted transmembrane or signal features, consistent with a cytosolic location. Accepted as the core localization.
human	GGCT	genes/human/GGCT/GGCT-ai-review.yaml	GGCT	O75223	NCBITaxon:9606	Homo sapiens	4	R-HSA-1247922	GGCT transforms gGluCys to OPRO	yes	reactome/R-HSA-1247922.md	GGCT transforms gGluCys to OPRO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the correct core subcellular location of GGCT. The Reactome reaction (GGCT transforms gGluCys to OPRO) places the gamma-glutamyl cyclotransferase step in the cytosol, consistent with UniProt and with direct purification from the cytosolic fraction (PubMed:16765912).
human	GGPS1	genes/human/GGPS1/GGPS1-ai-review.yaml	GGPS1	O95749	NCBITaxon:9606	Homo sapiens	25	R-HSA-1655832	Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)	yes	reactome/R-HSA-1655832.md	Expression of Geranylgeranyl Pyrophosphate Synthase (GGPS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic location (expression of GGPS1 event). Consistent with the IDA and IMP localization evidence; accepted.
human	GGPS1	genes/human/GGPS1/GGPS1-ai-review.yaml	GGPS1	O95749	NCBITaxon:9606	Homo sapiens	26	R-HSA-9717830	GGPS1 hexamer transfers IPPP to GPP	yes	reactome/R-HSA-9717830.md	GGPS1 hexamer transfers IPPP to GPP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic location (GGPS1 hexamer transfers IPPP to GPP reaction). Consistent with primary cytosolic localization; accepted.
human	GGPS1	genes/human/GGPS1/GGPS1-ai-review.yaml	GGPS1	O95749	NCBITaxon:9606	Homo sapiens	27	R-HSA-9717834	GGPS1 hexamer transfers IPPP to DMAPP	yes	reactome/R-HSA-9717834.md	GGPS1 hexamer transfers IPPP to DMAPP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic location (GGPS1 hexamer transfers IPPP to DMAPP reaction). Consistent with primary cytosolic localization; accepted.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	13	R-HSA-5602984	Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG	yes	reactome/R-HSA-5602984.md	Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG	Homo sapiens	GO:0036374	glutathione gamma-glutamate hydrolase	TAS	enables	MF	false		ACCEPT	Reactome TAS for the core glutathione hydrolase MF (this reaction models defective GGT1 failing to hydrolyse aflatoxin-GSH conjugates, but is annotated to the normal MF GGT1 enables).
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	14	R-HSA-9035966	Defective GGT1 does not hydrolyse GSH	yes	reactome/R-HSA-9035966.md	Defective GGT1 does not hydrolyse GSH	Homo sapiens	GO:0036374	glutathione gamma-glutamate hydrolase	TAS	enables	MF	false		ACCEPT	Reactome TAS for the core glutathione hydrolase MF (defective-GGT1 GSH-hydrolysis reaction, annotated to the normal enabled MF).
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	30	R-HSA-266046	GGT1, 5 dimers hydrolyse LTC4 to LTD4	yes	reactome/R-HSA-266046.md	GGT1, 5 dimers hydrolyse LTC4 to LTD4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing GGT1 at the plasma membrane (LTC4->LTD4 reaction on the outer cell surface); correct core compartment.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	31	R-HSA-5433072	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG	yes	reactome/R-HSA-5433072.md	GGTs hydrolyse glutamate from AFXBO-SG, AFNBO-SG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (aflatoxin-GSH conjugate hydrolysis at the plasma membrane); correct compartment.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	32	R-HSA-8943279	GGT dimers hydrolyse GSH	yes	reactome/R-HSA-8943279.md	GGT dimers hydrolyse GSH	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (GGT dimers hydrolyse GSH at the plasma membrane); correct compartment.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	33	R-HSA-9753634	GGT dimers hydrolyse APAP-SG	yes	reactome/R-HSA-9753634.md	GGT dimers hydrolyse APAP-SG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (acetaminophen-GSH conjugate hydrolysis at the plasma membrane); correct compartment.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	35	R-HSA-5602984	Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG	yes	reactome/R-HSA-5602984.md	Defective GGT1 does not hydrolyse glutamate from AFXBO-SG, AFNBO-SG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing GGT1 at the plasma membrane (defective-GGT1 aflatoxin-GSH reaction); correct compartment.
human	GGT1	genes/human/GGT1/GGT1-ai-review.yaml	GGT1	P19440	NCBITaxon:9606	Homo sapiens	36	R-HSA-9035966	Defective GGT1 does not hydrolyse GSH	yes	reactome/R-HSA-9035966.md	Defective GGT1 does not hydrolyse GSH	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing GGT1 at the plasma membrane (defective-GGT1 GSH reaction); correct compartment.
human	GHSR	genes/human/GHSR/GHSR-ai-review.yaml	GHSR	Q92847	NCBITaxon:9606	Homo sapiens	11	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The seven-transmembrane receptor functions at the cell surface.
human	GHSR	genes/human/GHSR/GHSR-ai-review.yaml	GHSR	Q92847	NCBITaxon:9606	Homo sapiens	12	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The seven-transmembrane receptor functions at the cell surface.
human	GHSR	genes/human/GHSR/GHSR-ai-review.yaml	GHSR	Q92847	NCBITaxon:9606	Homo sapiens	13	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The seven-transmembrane receptor functions at the cell surface.
human	GLA	genes/human/GLA/GLA-ai-review.yaml	GLA	P06280	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome extracellular-region placement is compatible with neutrophil degranulation/exocytosis but is not the core GLA location.
human	GLA	genes/human/GLA/GLA-ai-review.yaml	GLA	P06280	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Azurophil-granule lumen placement is a specialized neutrophil granule localization and not the core site of GLA activity.
human	GLA	genes/human/GLA/GLA-ai-review.yaml	GLA	P06280	NCBITaxon:9606	Homo sapiens	23	R-HSA-1605736	GLA hydrolyzes PSAP(195-273):Gb3Cer:PE	yes	reactome/R-HSA-1605736.md	GLA hydrolyzes PSAP(195-273):Gb3Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome lysosomal-lumen annotation accompanies the modeled Gb3Cer hydrolysis reaction.
human	GLA	genes/human/GLA/GLA-ai-review.yaml	GLA	P06280	NCBITaxon:9606	Homo sapiens	24	R-HSA-9841189	GLA hydrolyzes PSAP(195-273):Gal2Cer:PE	yes	reactome/R-HSA-9841189.md	GLA hydrolyzes PSAP(195-273):Gal2Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome lysosomal-lumen annotation accompanies the modeled Gal2Cer hydrolysis reaction.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	17	R-HSA-2265534	Defective GLB1 does not hydrolyse a glycosaminoglycan	yes	reactome/R-HSA-2265534.md	Defective GLB1 does not hydrolyse a glycosaminoglycan	Homo sapiens	GO:0004565	beta-galactosidase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation (from the pathway describing defective GLB1 failing to hydrolyze a glycosaminoglycan) supporting beta-galactosidase activity.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	18	R-HSA-9036061	Defective GLB1 does not hydrolyse linker chain(2)	yes	reactome/R-HSA-9036061.md	Defective GLB1 does not hydrolyse linker chain(2)	Homo sapiens	GO:0004565	beta-galactosidase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation supporting beta-galactosidase activity.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	36	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to extracellular region via the neutrophil azurophil-granule exocytosis pathway.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	37	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to extracellular region via the ficolin-rich-granule exocytosis pathway.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	38	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to azurophil granule lumen (neutrophil degranulation pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	39	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to ficolin-1-rich granule lumen (neutrophil degranulation pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	43	R-HSA-2265534	Defective GLB1 does not hydrolyse a glycosaminoglycan	yes	reactome/R-HSA-2265534.md	Defective GLB1 does not hydrolyse a glycosaminoglycan	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (defective GLB1 glycosaminoglycan hydrolysis pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	44	R-HSA-9036061	Defective GLB1 does not hydrolyse linker chain(2)	yes	reactome/R-HSA-9036061.md	Defective GLB1 does not hydrolyse linker chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	45	R-HSA-1605624	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	yes	reactome/R-HSA-1605624.md	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (mobilized GM1 hydrolysis pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	46	R-HSA-1605724	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	yes	reactome/R-HSA-1605724.md	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	47	R-HSA-1606312	GLB1 hydrolyzes SapB/C:LacCer	yes	reactome/R-HSA-1606312.md	GLB1 hydrolyzes SapB/C:LacCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (GLB1 hydrolyzes SapB/C:LacCer pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	48	R-HSA-1630306	GLB1 hydrolyses a glycosaminoglycan	yes	reactome/R-HSA-1630306.md	GLB1 hydrolyses a glycosaminoglycan	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (GLB1 hydrolyses a glycosaminoglycan pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	49	R-HSA-2090079	GLB1 hydrolyses linker chain(2)	yes	reactome/R-HSA-2090079.md	GLB1 hydrolyses linker chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (GLB1 hydrolyses keratan sulfate linker chain pathway).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	50	R-HSA-4084999	NEU1 hydrolyses Neu5Ac from glycoconjugates	yes	reactome/R-HSA-4084999.md	NEU1 hydrolyses Neu5Ac from glycoconjugates	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (from a sialic-acid-metabolism pathway that co-locates the CTSA/NEU1/GLB1 complex components).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	51	R-HSA-4341669	Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates	yes	reactome/R-HSA-4341669.md	Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (defective NEU1 pathway that includes GLB1 complex context).
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	52	R-HSA-9638120	NEU4 hydrolyses Neu5Ac from glycoconjugates	yes	reactome/R-HSA-9638120.md	NEU4 hydrolyses Neu5Ac from glycoconjugates	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen.
human	GLB1	genes/human/GLB1/GLB1-ai-review.yaml	GLB1	P16278	NCBITaxon:9606	Homo sapiens	53	R-HSA-9840795	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2	yes	reactome/R-HSA-9840795.md	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to lysosomal lumen (beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 pathway).
human	GLDC	genes/human/GLDC/GLDC-ai-review.yaml	GLDC	P23378	NCBITaxon:9606	Homo sapiens	15	R-HSA-5693967	PXLP-K754-GLDC dimer decarboxylates Gly	yes	reactome/R-HSA-5693967.md	PXLP-K754-GLDC dimer decarboxylates Gly	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Most precise localisation: the glycine decarboxylation reaction occurs in the mitochondrial matrix. Retained as the informative compartment.
human	GLIPR1	genes/human/GLIPR1/GLIPR1-ai-review.yaml	GLIPR1	P48060	NCBITaxon:9606	Homo sapiens	8	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places GLIPR1 among azurophil-granule membrane proteins released during neutrophil degranulation.
human	GLIPR1	genes/human/GLIPR1/GLIPR1-ai-review.yaml	GLIPR1	P48060	NCBITaxon:9606	Homo sapiens	10	R-HSA-1989772	Expression of GLIPR1	yes	reactome/R-HSA-1989772.md	Expression of GLIPR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome models expressed GLIPR1 protein at the plasma membrane.
human	GLIPR1	genes/human/GLIPR1/GLIPR1-ai-review.yaml	GLIPR1	P48060	NCBITaxon:9606	Homo sapiens	11	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome assigns plasma-membrane localization after exocytosis of GLIPR1-containing azurophil granules in neutrophils.
human	GLO1	genes/human/GLO1/GLO1-ai-review.yaml	GLO1	Q04760	NCBITaxon:9606	Homo sapiens	15	R-HSA-5694071	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH	yes	reactome/R-HSA-5694071.md	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the zinc-loaded GLO1 dimer reaction in the cytosol.
human	GLRX5	genes/human/GLRX5/GLRX5-ai-review.yaml	GLRX5	Q86SX6	NCBITaxon:9606	Homo sapiens	24	R-HSA-8878815	Formation of 4Fe-4S cluster on ISCA1:ISCA2	yes	reactome/R-HSA-8878815.md	Formation of 4Fe-4S cluster on ISCA1:ISCA2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"This Reactome pathway annotation describes ""Formation of 4Fe-4S cluster on ISCA1:ISCA2"" which involves GLRX5 transferring [2Fe-2S] clusters to ISCA proteins for subsequent [4Fe-4S] cluster assembly. The mitochondrial matrix localization is accurate."
human	GLS	genes/human/GLS/GLS-ai-review.yaml	GLS	O94925	NCBITaxon:9606	Homo sapiens	23	R-HSA-70609	glutamine + H2O => glutamate + NH4+ (GLS)	yes	reactome/R-HSA-70609.md	glutamine + H2O => glutamate + NH4+ (GLS)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the glutaminase reaction in the mitochondrial matrix. Consistent with UniProt; accepted as the specific compartment of catalysis.
human	GLS2	genes/human/GLS2/GLS2-ai-review.yaml	GLS2	Q9UI32	NCBITaxon:9606	Homo sapiens	13	R-HSA-5632924	TP53 stimulates GLS2 transcription	yes	reactome/R-HSA-5632924.md	TP53 stimulates GLS2 transcription	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS placing GLS2 in the mitochondrial matrix within the ""TP53 stimulates GLS2 transcription"" pathway. Correct compartment for this soluble matrix enzyme."
human	GLS2	genes/human/GLS2/GLS2-ai-review.yaml	GLS2	Q9UI32	NCBITaxon:9606	Homo sapiens	14	R-HSA-70609	glutamine + H2O => glutamate + NH4+ (GLS)	yes	reactome/R-HSA-70609.md	glutamine + H2O => glutamate + NH4+ (GLS)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing the glutaminase reaction (glutamine + H2O => glutamate + NH4+) in the mitochondrial matrix. Correct core localization; redundant with the other matrix annotation but well supported.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	29	R-HSA-5688276	SIRT4 transfers ADPRib to GLUD	yes	reactome/R-HSA-5688276.md	SIRT4 transfers ADPRib to GLUD	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix (in the context of SIRT4 transferring ADP-ribose to GLUD). This is the specific, correct site of the active enzyme. Core location.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	30	R-HSA-5688289	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2	yes	reactome/R-HSA-5688289.md	SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix (SIRT3 deacetylation reaction context). Correct core location of the enzyme.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	34	R-HSA-70589	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)	yes	reactome/R-HSA-70589.md	alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ (GLUD1,2)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix, annotated on the reverse GDH reaction (alpha-ketoglutarate + NH4+ + NAD(P)H -> glutamate). Correct core location.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	35	R-HSA-70600	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)	yes	reactome/R-HSA-70600.md	glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ (GLUD1,2)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix, annotated on the forward GDH reaction (glutamate + NAD(P)+ -> alpha-ketoglutarate). Correct core location.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	36	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix (LONP1 degradation of matrix proteins context). Correct core location.
human	GLUD1	genes/human/GLUD1/GLUD1-ai-review.yaml	GLUD1	P00367	NCBITaxon:9606	Homo sapiens	37	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization to the mitochondrial matrix (LONP1 binding of matrix proteins context). Correct core location.
human	GLUL	genes/human/GLUL/GLUL-ai-review.yaml	GLUL	P15104	NCBITaxon:9606	Homo sapiens	38	R-HSA-70606	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]	yes	reactome/R-HSA-70606.md	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Core cytosolic localization asserted by Reactome for the GS-catalyzed reaction. Concordant with experimental IDA evidence.
human	GLYCTK	genes/human/GLYCTK/GLYCTK-ai-review.yaml	GLYCTK	Q8IVS8	NCBITaxon:9606	Homo sapiens	15	R-HSA-70350	Fructose catabolism	yes	reactome/R-HSA-70350.md	Fructose catabolism	Homo sapiens	GO:0061624	fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	TAS	involved_in	BP	false		MODIFY	GLYCTK participates in fructose catabolism by phosphorylating D-glycerate, a metabolite generated downstream of fructose metabolism, to 3-phosphoglycerate.
human	GLYCTK	genes/human/GLYCTK/GLYCTK-ai-review.yaml	GLYCTK	Q8IVS8	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799495	GLYCTK phosphorylates DGA to 3PDGA	yes	reactome/R-HSA-6799495.md	GLYCTK phosphorylates DGA to 3PDGA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with the UniProt isoform annotation and with GLYCTK acting as a soluble metabolic enzyme.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	22	R-HSA-9840310	Glycosphingolipid catabolism	yes	reactome/R-HSA-9840310.md	Glycosphingolipid catabolism	Homo sapiens	GO:0046479	glycosphingolipid catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway (Glycosphingolipid catabolism) annotation to glycosphingolipid catabolic process. Accurate for GM2A's role in degradation of GM2 and related glycosphingolipids.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	26	R-HSA-1605717	GM2A binds and mobilizes ligands	yes	reactome/R-HSA-1605717.md	GM2A binds and mobilizes ligands	Homo sapiens	GO:0030290	sphingolipid activator protein activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation to sphingolipid activator protein activity, the family-level cofactor activity for lysosomal sphingolipid degradation. Accurate for GM2A (SAP-3).
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation (via neutrophil degranulation / exocytosis of azurophil granule lumen proteins) placing GM2A in the extracellular region. Reflects a secretory pool, not the primary functional site.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	28	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation to azurophil granule lumen, via the neutrophil-degranulation pathway. A secretory-granule localization, not the primary lysosomal functional site.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	31	R-HSA-1605595	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	yes	reactome/R-HSA-1605595.md	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (bHEXA hydrolyzes GM2A-GM2 to GM2A-GM3). This is the primary, correct functional compartment for GM2A.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	32	R-HSA-1605624	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	yes	reactome/R-HSA-1605624.md	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2). Correct functional compartment; duplicate lysosomal-lumen localization.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	33	R-HSA-1605717	GM2A binds and mobilizes ligands	yes	reactome/R-HSA-1605717.md	GM2A binds and mobilizes ligands	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (GM2A binds and mobilizes ligands). Correct functional compartment; duplicate lysosomal-lumen localization.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	34	R-HSA-9840795	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2	yes	reactome/R-HSA-9840795.md	Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (beta-galactosidases hydrolyze GM2A-GA1 to GM2A-GA2). Correct functional compartment; duplicate lysosomal-lumen localization.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	35	R-HSA-9840833	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	yes	reactome/R-HSA-9840833.md	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (bHEXA,bHEXB hydrolyze GM2A-GA2 to GM2A-LacCer). Correct functional compartment; duplicate lysosomal-lumen localization.
human	GM2A	genes/human/GM2A/GM2A-ai-review.yaml	GM2A	P17900	NCBITaxon:9606	Homo sapiens	36	R-HSA-9840884	bHEXA,bHEXS hydrolyze GM2A:SM2	yes	reactome/R-HSA-9840884.md	bHEXA,bHEXS hydrolyze GM2A:SM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to lysosomal lumen (bHEXA,bHEXS hydrolyze GM2A-SM2). Correct functional compartment; duplicate lysosomal-lumen localization.
human	GMFG	genes/human/GMFG/GMFG-ai-review.yaml	GMFG	O60234	NCBITaxon:9606	Homo sapiens	10	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome links GMFG to neutrophil degranulation/exocytosis datasets, where proteins can be released or detected extracellularly.
human	GMFG	genes/human/GMFG/GMFG-ai-review.yaml	GMFG	O60234	NCBITaxon:9606	Homo sapiens	11	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome extracellular-region annotation from ficolin-rich granule exocytosis context.
human	GMFG	genes/human/GMFG/GMFG-ai-review.yaml	GMFG	O60234	NCBITaxon:9606	Homo sapiens	12	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome location may reflect detection in neutrophil granule contents rather than the site of GMFG's actin-remodeling activity.
human	GMFG	genes/human/GMFG/GMFG-ai-review.yaml	GMFG	O60234	NCBITaxon:9606	Homo sapiens	13	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Ficolin-1-rich granule lumen is plausible as Reactome immune-cell context but is not the primary functional site for GMFG.
human	GMPS	genes/human/GMPS/GMPS-ai-review.yaml	GMPS	P49915	NCBITaxon:9606	Homo sapiens	10	R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	yes	reactome/R-HSA-73817.md	Purine ribonucleoside monophosphate biosynthesis	Homo sapiens	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway-level (Purine ribonucleoside monophosphate biosynthesis) assignment. GMP is a purine ribonucleoside monophosphate, so GMPS participates in this pathway; however this term is broader than the specific GMP biosynthetic process.
human	GMPS	genes/human/GMPS/GMPS-ai-review.yaml	GMPS	P49915	NCBITaxon:9606	Homo sapiens	17	R-HSA-73792	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate	yes	reactome/R-HSA-73792.md	XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction (XMP + L-Glutamine + ATP + H2O => GMP + ...) describing cytosolic GMP synthase, supporting cytosolic localization.
human	GMPS	genes/human/GMPS/GMPS-ai-review.yaml	GMPS	P49915	NCBITaxon:9606	Homo sapiens	18	R-HSA-9748957	GMPS dimer transforms 6TXMP to 6TGMP	yes	reactome/R-HSA-9748957.md	GMPS dimer transforms 6TXMP to 6TGMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction (GMPS dimer transforms 6TXMP to 6TGMP, thiopurine drug activation) placing GMPS in the cytosol; duplicate cytosol localization support.
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	13	R-HSA-4088338	Defective GNE does not hydrolyse UDP-GlcNAc	yes	reactome/R-HSA-4088338.md	Defective GNE does not hydrolyse UDP-GlcNAc	Homo sapiens	GO:0008761	UDP-N-acetylglucosamine 2-epimerase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the epimerase activity (reaction ""Defective GNE does not hydrolyse UDP-GlcNAc""). Corroborates the core epimerase function. Accept."
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	14	R-HSA-4088322	Defective GNE does not phosphorylate ManNAc to ManNAc-6-P	yes	reactome/R-HSA-4088322.md	Defective GNE does not phosphorylate ManNAc to ManNAc-6-P	Homo sapiens	GO:0009384	N-acylmannosamine kinase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the ManNAc kinase activity (reaction ""Defective GNE does not phosphorylate ManNAc to ManNAc-6-P""). Corroborates the core kinase function. Accept."
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	25	R-HSA-4088322	Defective GNE does not phosphorylate ManNAc to ManNAc-6-P	yes	reactome/R-HSA-4088322.md	Defective GNE does not phosphorylate ManNAc to ManNAc-6-P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol location, associated with the ManNAc kinase reaction. Consistent with the curated location. Accept.
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	26	R-HSA-4088338	Defective GNE does not hydrolyse UDP-GlcNAc	yes	reactome/R-HSA-4088338.md	Defective GNE does not hydrolyse UDP-GlcNAc	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol location, associated with the epimerase reaction. Consistent with the curated location. Accept.
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	27	R-HSA-4085021	GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP	yes	reactome/R-HSA-4085021.md	GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol location (reaction: GNE hydrolyzes and epimerises UDP-GlcNAc to ManNAc and UDP). Consistent with the curated location. Accept.
human	GNE	genes/human/GNE/GNE-ai-review.yaml	GNE	Q9Y223	NCBITaxon:9606	Homo sapiens	28	R-HSA-4085028	GNE phosphorylates ManNAc to ManNAc-6-P	yes	reactome/R-HSA-4085028.md	GNE phosphorylates ManNAc to ManNAc-6-P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol location (reaction: GNE phosphorylates ManNAc to ManNAc-6-P). Consistent with the curated location. Accept.
human	GNMT	genes/human/GNMT/GNMT-ai-review.yaml	GNMT	Q14749	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798317	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC	yes	reactome/R-HSA-6798317.md	GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization of the GNMT tetramer catalyzing the AdoMet-to-glycine methyl transfer.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	11	R-HSA-1483166	Synthesis of PA	yes	reactome/R-HSA-1483166.md	Synthesis of PA	Homo sapiens	GO:0006654	phosphatidic acid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places GNPAT's acyl-DHAP product in the pathway that feeds phosphatidic acid / glycerolipid synthesis. This is a peripheral, non-core role - experimental evidence shows peroxisomal DHAPAT does not normally contribute to nonether (diacyl) glycerolipid biosynthesis, so its main output is the ether-lipid branch.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	12	R-HSA-75896	Plasmalogen biosynthesis	yes	reactome/R-HSA-75896.md	Plasmalogen biosynthesis	Homo sapiens	GO:0008611	ether lipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (Plasmalogen biosynthesis) traceable annotation to ether lipid biosynthetic process. Core biological process of GNPAT.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	14	R-HSA-1483002	DHAP is converted to 1-acyl GO3P by GNPAT	yes	reactome/R-HSA-1483002.md	DHAP is converted to 1-acyl GO3P by GNPAT	Homo sapiens	GO:0016287	glycerone-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation of the core glycerone-phosphate O-acyltransferase activity (DHAP -> 1-acyl GO3P). Correct core function.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	15	R-HSA-75879	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	yes	reactome/R-HSA-75879.md	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	Homo sapiens	GO:0016287	glycerone-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation of the core glycerone-phosphate O-acyltransferase activity (palmitoyl-CoA + DHAP -> 1-palmitoylglycerone phosphate + CoASH). Correct core function.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	19	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This cytosol annotation derives from the Peroxisomal protein import Reactome pathway and reflects the transient cytosolic state of newly synthesized PTS1 cargo before import into the peroxisome. It does not represent the steady-state location of the mature enzyme, which is the peroxisomal membrane; as a standalone location claim it is an over-annotation.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	20	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	As above, this cytosol annotation comes from the peroxisomal protein import docking/translocation step and reflects pre-import cargo, not the steady-state location of the mature peroxisomal enzyme.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	29	R-HSA-1483002	DHAP is converted to 1-acyl GO3P by GNPAT	yes	reactome/R-HSA-1483002.md	DHAP is converted to 1-acyl GO3P by GNPAT	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation of peroxisomal membrane localization. Core location.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	30	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation of peroxisomal membrane localization. Core location.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	31	R-HSA-390427	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate	yes	reactome/R-HSA-390427.md	1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation of peroxisomal matrix localization. Compatible with the enzyme being a peripheral membrane protein on the matrix (lumenal) side of the peroxisomal membrane; kept as non-core given the more precise peroxisomal-membrane terms.
human	GNPAT	genes/human/GNPAT/GNPAT-ai-review.yaml	GNPAT	O15228	NCBITaxon:9606	Homo sapiens	32	R-HSA-75879	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	yes	reactome/R-HSA-75879.md	palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation of peroxisomal matrix localization, consistent with the enzyme's matrix (lumenal)-side membrane association. Kept as non-core relative to the peroxisomal-membrane terms.
human	GNPNAT1	genes/human/GNPNAT1/GNPNAT1-ai-review.yaml	GNPNAT1	Q96EK6	NCBITaxon:9606	Homo sapiens	15	R-HSA-449734	Acetylation of glucosamine 6-phosphate to GlcNAc6P	yes	reactome/R-HSA-449734.md	Acetylation of glucosamine 6-phosphate to GlcNAc6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that the GNPNAT1-catalyzed reaction occurs in the cytosol. The hexosamine biosynthetic pathway is cytosolic, so this is the functionally central subcellular location for the enzyme's core activity.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	12	R-HSA-2263495	Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S	yes	reactome/R-HSA-2263495.md	Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S	Homo sapiens	GO:0008449	N-acetylglucosamine-6-sulfatase activity	TAS	enables	MF	false		ACCEPT	TAS annotation (Reactome) to the specific sulfatase activity, in the context of the keratan sulfate degradation / MPS IIID pathway. Core molecular function; accept.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	17	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation (Reactome neutrophil-degranulation pathway) placing GNS in the extracellular region upon exocytosis of azurophil granule contents. Consistent with the biochemical observation that GNS is released from neutrophils; a secondary, context-dependent location. Keep as non-core.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	18	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation (Reactome ficolin-rich granule exocytosis pathway) placing GNS in the extracellular region upon degranulation. Same rationale as the other extracellular-region annotation; secondary location. Keep as non-core.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation (Reactome) to azurophil granule lumen, consistent with the experimental demonstration that GNS is a soluble matrix protein of neutrophil primary granules. Secondary, cell-type-specific location. Keep as non-core.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	20	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation (Reactome) to ficolin-1-rich granule lumen, from the neutrophil-degranulation curation. A specialized neutrophil granule subtype; secondary location. Keep as non-core.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	21	R-HSA-2263495	Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S	yes	reactome/R-HSA-2263495.md	Defective GNS does not hydrolyse 6-sulfate from GlcNAc6S	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome) to the lysosomal lumen, the compartment where GNS performs GlcNAc-6- sulfate desulfation during GAG catabolism. Core localization; accept.
human	GNS	genes/human/GNS/GNS-ai-review.yaml	GNS	P15586	NCBITaxon:9606	Homo sapiens	23	R-HSA-1638032	GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate	yes	reactome/R-HSA-1638032.md	GNS:Ca2+ cleaves sulfate from GlcNAc-6-sulfate units of keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome keratan sulfate degradation reaction) to lysosomal lumen. Redundant with the other lysosomal-lumen annotation and consistent with GNS's core compartment; accept.
human	GOT1	genes/human/GOT1/GOT1-ai-review.yaml	GOT1	P17174	NCBITaxon:9606	Homo sapiens	38	R-HSA-70581	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]	yes	reactome/R-HSA-70581.md	oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the GOT1-catalyzed reaction (oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate) to the cytosol. Correct and core.
human	GOT1	genes/human/GOT1/GOT1-ai-review.yaml	GOT1	P17174	NCBITaxon:9606	Homo sapiens	39	R-HSA-70592	PXLP-K259-GOT1 transaminates 2-OG and L-Asp	yes	reactome/R-HSA-70592.md	PXLP-K259-GOT1 transaminates 2-OG and L-Asp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS (PLP-K259-GOT1 transaminates 2-OG and L-Asp) localizing the enzyme to the cytosol. Correct and core.
human	GOT2	genes/human/GOT2/GOT2-ai-review.yaml	GOT2	P00505	NCBITaxon:9606	Homo sapiens	17	R-HSA-6784393	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)	yes	reactome/R-HSA-6784393.md	PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing GOT2 to the mitochondrial matrix (in the reaction where the PXLP-K279-GOT2 dimer transaminates 4-hydroxy-L-glutamate to 4-hydroxy-2-oxoglutarate). Correct and core.
human	GOT2	genes/human/GOT2/GOT2-ai-review.yaml	GOT2	P00505	NCBITaxon:9606	Homo sapiens	18	R-HSA-70596	GOT2 dimer transaminates L-Asp	yes	reactome/R-HSA-70596.md	GOT2 dimer transaminates L-Asp	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (GOT2 dimer transaminates L-Asp) localizing the enzyme to the mitochondrial matrix. Correct and core.
human	GOT2	genes/human/GOT2/GOT2-ai-review.yaml	GOT2	P00505	NCBITaxon:9606	Homo sapiens	19	R-HSA-70613	GOT2 transaminates OA and L-Glu	yes	reactome/R-HSA-70613.md	GOT2 transaminates OA and L-Glu	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (GOT2 transaminates OA and L-Glu) localizing the enzyme to the mitochondrial matrix. Correct and core; captures the reverse (aspartate-synthesizing) direction.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	16	R-HSA-114670	GPIb-IX-V binds to vWF:Collagen complex	yes	reactome/R-HSA-114670.md	GPIb-IX-V binds to vWF:Collagen complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-114670 (GPIb-IX-V binds to vWF:Collagen complex) correctly places GPIX at the plasma membrane as part of the GPIb-IX-V complex.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	17	R-HSA-158145	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex	yes	reactome/R-HSA-158145.md	factor XI + platelet glycoprotein (GP) Ib:IX:V complex -> factor XI:platelet glycoprotein (GP) Ib:IX:V complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-158145 (factor XI binding to GPIb-IX-V) confirms plasma membrane localization of the complex.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	18	R-HSA-158300	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)	yes	reactome/R-HSA-158300.md	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for factor XI activation at the GPIb-IX-V complex.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	19	R-HSA-158333	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)	yes	reactome/R-HSA-158333.md	factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for factor IX activation.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	20	R-HSA-158419	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)	yes	reactome/R-HSA-158419.md	factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for factor XI activation by thrombin at GPIb-IX-V.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	21	R-HSA-429529	Thrombin binding to GP1b:IX:V	yes	reactome/R-HSA-429529.md	Thrombin binding to GP1b:IX:V	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-429529 (Thrombin binding to GP1b:IX:V) confirms the plasma membrane localization of the receptor complex.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	22	R-HSA-430073	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress	yes	reactome/R-HSA-430073.md	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway addressing GPIb-IX-V binding to 14-3-3-zeta under shear stress.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	23	R-HSA-430076	GP1b-IX-V binds 14-3-3-zeta	yes	reactome/R-HSA-430076.md	GP1b-IX-V binds 14-3-3-zeta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for GPIb-IX-V binding to 14-3-3-zeta.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	24	R-HSA-430096	GP1b-IX-V binds filamin	yes	reactome/R-HSA-430096.md	GP1b-IX-V binds filamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-430096 (GP1b-IX-V binds filamin) confirms plasma membrane localization and cytoskeletal anchoring.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	25	R-HSA-443402	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K	yes	reactome/R-HSA-443402.md	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for GPIb-IX-V signaling involving PI3K.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	26	R-HSA-443418	GP1b signaling involves c-Src	yes	reactome/R-HSA-443418.md	GP1b signaling involves c-Src	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for GPIb signaling involving c-Src.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	27	R-HSA-9673223	FIX(29-461) variant is not activated (factor XIa catalyst)	yes	reactome/R-HSA-9673223.md	FIX(29-461) variant is not activated (factor XIa catalyst)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway addressing FIX variant activation defects.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	28	R-HSA-9823065	GPIb:IX:V binds to VWF multimer:collagen	yes	reactome/R-HSA-9823065.md	GPIb:IX:V binds to VWF multimer:collagen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for GPIb-IX-V binding to VWF multimer:collagen.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	29	R-HSA-9823706	VWF variant does not bind GPIb:IX:V	yes	reactome/R-HSA-9823706.md	VWF variant does not bind GPIb:IX:V	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway addressing VWF variant binding defects.
human	GP9	genes/human/GP9/GP9-ai-review.yaml	GP9	P14770	NCBITaxon:9606	Homo sapiens	30	R-HSA-9844251	GP1BA variant binds to VWF multimer:collagen	yes	reactome/R-HSA-9844251.md	GP1BA variant binds to VWF multimer:collagen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for GP1BA variant binding to VWF.
human	GPAA1	genes/human/GPAA1/GPAA1-ai-review.yaml	GPAA1	O43292	NCBITaxon:9606	Homo sapiens	43	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of GPAA1 (as part of the GPI transamidase reaction) to the ER membrane.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	13	R-HSA-1483166	Synthesis of PA	yes	reactome/R-HSA-1483166.md	Synthesis of PA	Homo sapiens	GO:0006654	phosphatidic acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	phosphatidic acid biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	14	R-HSA-75109	Triglyceride biosynthesis	yes	reactome/R-HSA-75109.md	Triglyceride biosynthesis	Homo sapiens	GO:0019432	triglyceride biosynthetic process	TAS	involved_in	BP	false		ACCEPT	triglyceride biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	23	R-HSA-1482695	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)	yes	reactome/R-HSA-1482695.md	G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	24	R-HSA-1655837	Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)	yes	reactome/R-HSA-1655837.md	Expression of Glycerol-3-phosphate Acyltransferase (GPAM, GPAT)	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	25	R-HSA-75886	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]	yes	reactome/R-HSA-75886.md	glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPAM	genes/human/GPAM/GPAM-ai-review.yaml	GPAM	Q9HCL2	NCBITaxon:9606	Homo sapiens	26	R-HSA-8932020	GPAM gene expression is stimulated by RUNX1 and ESR1	yes	reactome/R-HSA-8932020.md	GPAM gene expression is stimulated by RUNX1 and ESR1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	17	R-HSA-9940993	PXYLP1 dephosphorylates Xyl moiety	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	GPC2 is annotated to Golgi lumen based on Reactome pathway annotations for heparan sulfate proteoglycan biosynthesis. As a proteoglycan, GPC2 transits through the Golgi where its heparan sulfate chains are synthesized and modified. This represents biosynthetic trafficking rather than the functional site.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	18	R-HSA-9941039	FAM20B phosphorylates Xyl moiety	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Golgi lumen annotation from Reactome FAM20B phosphorylation pathway. Same assessment as above.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	21	R-HSA-1878002	XYLTs transfer Xyl to core protein	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome xylosyltransferase pathway for GAG linker biosynthesis. Non-core biosynthetic localization.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	22	R-HSA-1889955	B3GAT dimers transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome B3GAT pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	23	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome B3GALT6 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	24	R-HSA-2022851	EXT1:EXT2 transfers GlcNAc to the heparan chain	yes	reactome/R-HSA-2022851.md	EXT1:EXT2 transfers GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome EXT1:EXT2 heparan chain extension pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	25	R-HSA-2022856	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2022856.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome heparan sulfate biosynthesis.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	26	R-HSA-2022860	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	yes	reactome/R-HSA-2022860.md	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome NDST sulfation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	27	R-HSA-2022887	NDST1-4 N-deacetylates GlcNAc residues in heparan	yes	reactome/R-HSA-2022887.md	NDST1-4 N-deacetylates GlcNAc residues in heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome NDST deacetylation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	28	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome HSPG secretion pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	29	R-HSA-2076383	HS3ST1 sulfates GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076383.md	HS3ST1 sulfates GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome HS3ST1 sulfation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	30	R-HSA-2076392	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2076392.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome heparan biosynthesis.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	31	R-HSA-2076419	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	yes	reactome/R-HSA-2076419.md	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome HS6ST sulfation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	32	R-HSA-2076508	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	yes	reactome/R-HSA-2076508.md	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome HS2ST1 sulfation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	33	R-HSA-2076611	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076611.md	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome HS3ST2-6 sulfation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	34	R-HSA-3560802	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective B3GAT3 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	35	R-HSA-3656254	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656254.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT2 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	36	R-HSA-3656257	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656257.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT1 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	37	R-HSA-3656261	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656261.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT1 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	38	R-HSA-3656267	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656267.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT2 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	39	R-HSA-1678694	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	yes	reactome/R-HSA-1678694.md	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome HPSE2 binding pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	40	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome HS-GAG degradation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	41	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome HSPG secretion pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	42	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome retinoid transport pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	43	R-HSA-2423785	CR:atREs binds apoE and HSPG	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome retinoid metabolism pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	44	R-HSA-2429643	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome retinoid metabolism pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	45	R-HSA-9694579	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	yes	reactome/R-HSA-9694579.md	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome SARS-CoV-2 entry pathway. HSPGs including glypicans can serve as attachment factors for viral entry.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	46	R-HSA-9694661	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9694661.md	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome SARS-CoV-2 entry pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	47	R-HSA-9698988	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	yes	reactome/R-HSA-9698988.md	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome SARS-CoV-2 entry pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	48	R-HSA-9699007	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9699007.md	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome SARS-CoV-2 entry pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	49	R-HSA-9836899	sG binds to HSPGs	yes	reactome/R-HSA-9836899.md	sG binds to HSPGs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome RSV attachment pathway. sG binds to HSPGs.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	50	R-HSA-1667005	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Lysosomal lumen annotation from Reactome heparanase cleavage pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	51	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Lysosomal lumen annotation from Reactome HS-GAG degradation pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	52	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome B4GALT7 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	53	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective B4GALT7 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	54	R-HSA-9036285	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036285.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT1 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	55	R-HSA-9036289	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036289.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective EXT2 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	56	R-HSA-9953259	EXTL3 dimer transfers GlcNAc to the GAG linker	yes	reactome/R-HSA-9953259.md	EXTL3 dimer transfers GlcNAc to the GAG linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome EXTL3 pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	57	R-HSA-1667005	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome heparanase pathway.
human	GPC2	genes/human/GPC2/GPC2-ai-review.yaml	GPC2	Q8N158	NCBITaxon:9606	Homo sapiens	58	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen annotation from Reactome defective B3GALT6 pathway.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	21	R-HSA-9940993	Reactome pathway R-HSA-9940993	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway indicating GPC4 presence in Golgi lumen during glycosaminoglycan biosynthesis. PXYLP1 dephosphorylates xylose moiety.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	22	R-HSA-9941039	Reactome pathway R-HSA-9941039	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway. FAM20B phosphorylates xylose moiety during GAG chain assembly.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	27	R-HSA-1878002	Reactome pathway R-HSA-1878002	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. XYLTs transfer xylose to core protein during GAG synthesis.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	28	R-HSA-1889955	Reactome pathway R-HSA-1889955	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. B3GAT dimers transfer glucuronic acid during linker synthesis.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	29	R-HSA-1889978	Reactome pathway R-HSA-1889978	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. B3GALT6 transfers galactose during linker synthesis.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	30	R-HSA-2022851	Reactome pathway R-HSA-2022851	yes	reactome/R-HSA-2022851.md	EXT1:EXT2 transfers GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. EXT1:EXT2 complex transfers GlcNAc to heparan chain.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	31	R-HSA-2022856	Reactome pathway R-HSA-2022856	yes	reactome/R-HSA-2022856.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. EXT1:EXT2 complex transfers glucuronic acid to heparan.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	32	R-HSA-2022860	Reactome pathway R-HSA-2022860	yes	reactome/R-HSA-2022860.md	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. NDSTs sulfate glucosamine residues forming heparan sulfate.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	33	R-HSA-2022887	Reactome pathway R-HSA-2022887	yes	reactome/R-HSA-2022887.md	NDST1-4 N-deacetylates GlcNAc residues in heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. NDSTs N-deacetylate GlcNAc residues.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	34	R-HSA-2024108	Reactome pathway R-HSA-2024108	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HSPGs are secreted to plasma membrane.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	35	R-HSA-2076383	Reactome pathway R-HSA-2076383	yes	reactome/R-HSA-2076383.md	HS3ST1 sulfates GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS3ST1 sulfates glucosamine at C3.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	36	R-HSA-2076392	Reactome pathway R-HSA-2076392	yes	reactome/R-HSA-2076392.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. EXT1:EXT2 transfers glucuronic acid.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	37	R-HSA-2076419	Reactome pathway R-HSA-2076419	yes	reactome/R-HSA-2076419.md	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS6STs sulfate glucosamine at C6.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	38	R-HSA-2076508	Reactome pathway R-HSA-2076508	yes	reactome/R-HSA-2076508.md	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS2ST1 sulfates iduronic acid at C2.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	39	R-HSA-2076611	Reactome pathway R-HSA-2076611	yes	reactome/R-HSA-2076611.md	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS3ST2-6 sulfate glucosamine at C3.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	40	R-HSA-3560802	Reactome pathway R-HSA-3560802	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway. Defective B3GAT3 affecting linker synthesis.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	41	R-HSA-3656254	Reactome pathway R-HSA-3656254	yes	reactome/R-HSA-3656254.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway. Defective EXT2 in EXT1:EXT2 complex.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	42	R-HSA-3656257	Reactome pathway R-HSA-3656257	yes	reactome/R-HSA-3656257.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway. Defective EXT1.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	43	R-HSA-3656261	Reactome pathway R-HSA-3656261	yes	reactome/R-HSA-3656261.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	44	R-HSA-3656267	Reactome pathway R-HSA-3656267	yes	reactome/R-HSA-3656267.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	45	R-HSA-1678694	Reactome pathway R-HSA-1678694	yes	reactome/R-HSA-1678694.md	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Heparanase 2 binds heparan sulfate proteoglycans at plasma membrane.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	46	R-HSA-2024084	Reactome pathway R-HSA-2024084	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS-GAGs translocate to lysosome for degradation.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	47	R-HSA-2024108	Reactome pathway R-HSA-2024108	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HSPGs secreted to plasma membrane.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	48	R-HSA-2404131	Reactome pathway R-HSA-2404131	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. LRPs transport retinol-HSPG complexes.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	49	R-HSA-2423785	Reactome pathway R-HSA-2423785	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Retinol-ester complexes bind apoE and HSPG.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	50	R-HSA-2429643	Reactome pathway R-HSA-2429643	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. NREH hydrolyzes retinol esters from HSPG complexes.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	51	R-HSA-9694579	Reactome pathway R-HSA-9694579	yes	reactome/R-HSA-9694579.md	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome. SARS-CoV-2 spike glycoprotein binds ACE2 on host cells. HSPGs can act as co-receptors for viral entry.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	52	R-HSA-9694661	Reactome pathway R-HSA-9694661	yes	reactome/R-HSA-9694661.md	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome. TMPRSS2 mediated spike protein cleavage.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	53	R-HSA-9698988	Reactome pathway R-HSA-9698988	yes	reactome/R-HSA-9698988.md	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome. SARS-CoV-2 membrane fusion.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	54	R-HSA-9699007	Reactome pathway R-HSA-9699007	yes	reactome/R-HSA-9699007.md	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome. FURIN mediated spike cleavage.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	55	R-HSA-9836899	Reactome pathway R-HSA-9836899	yes	reactome/R-HSA-9836899.md	sG binds to HSPGs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome. RSV sG binds to HSPGs.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	56	R-HSA-1667005	Reactome pathway R-HSA-1667005	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Heparanase cleaves heparan sulfate in lysosome.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	57	R-HSA-2024084	Reactome pathway R-HSA-2024084	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. HS-GAGs translocate to lysosome.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	58	R-HSA-1889981	Reactome pathway R-HSA-1889981	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. B4GALT7 transfers galactose to xylosyl unit.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	59	R-HSA-3560804	Reactome pathway R-HSA-3560804	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway. Defective B4GALT7.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	60	R-HSA-9036285	Reactome pathway R-HSA-9036285	yes	reactome/R-HSA-9036285.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	61	R-HSA-9036289	Reactome pathway R-HSA-9036289	yes	reactome/R-HSA-9036289.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	62	R-HSA-9953259	Reactome pathway R-HSA-9953259	yes	reactome/R-HSA-9953259.md	EXTL3 dimer transfers GlcNAc to the GAG linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. EXTL3 transfers GlcNAc to GAG linker.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	63	R-HSA-1667005	Reactome pathway R-HSA-1667005	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Note this reference is for lysosomal heparanase activity, may be a pathway data entry issue.
human	GPC4	genes/human/GPC4/GPC4-ai-review.yaml	GPC4	O75487	NCBITaxon:9606	Homo sapiens	64	R-HSA-4420365	Reactome pathway R-HSA-4420365	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome disease pathway. Defective B3GALT6.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	13	R-HSA-9940993	Reactome pathway R-HSA-9940993	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for PXYLP1 dephosphorylation of xylose moiety during GAG linker biosynthesis. Golgi is where HS-GAG biosynthesis occurs.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	14	R-HSA-9941039	Reactome pathway R-HSA-9941039	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for FAM20B phosphorylation of xylose moiety during GAG linker biosynthesis.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	18	R-HSA-1878002	Reactome pathway R-HSA-1878002	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for xylosyltransferases adding xylose to core protein during GAG linker biosynthesis.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	19	R-HSA-1889955	Reactome pathway R-HSA-1889955	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for B3GAT dimer transferring GlcA to tetrasaccharide linker.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	20	R-HSA-1889978	Reactome pathway R-HSA-1889978	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for B3GALT6 transferring Gal to tetrasaccharide linker.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	21	R-HSA-2022851	Reactome pathway R-HSA-2022851	yes	reactome/R-HSA-2022851.md	EXT1:EXT2 transfers GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for EXT1:EXT2 transferring GlcNAc to heparan chain.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	22	R-HSA-2022856	Reactome pathway R-HSA-2022856	yes	reactome/R-HSA-2022856.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for EXT1:EXT2 transferring GlcA to heparan.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	23	R-HSA-2022860	Reactome pathway R-HSA-2022860	yes	reactome/R-HSA-2022860.md	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for NDST1-4 sulfating glucosamine residue to form HS.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	24	R-HSA-2022887	Reactome pathway R-HSA-2022887	yes	reactome/R-HSA-2022887.md	NDST1-4 N-deacetylates GlcNAc residues in heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for NDST1-4 N-deacetylating GlcNAc residues in heparan.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	25	R-HSA-2024108	Reactome pathway R-HSA-2024108	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HSPG secretion to plasma membrane.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	26	R-HSA-2076383	Reactome pathway R-HSA-2076383	yes	reactome/R-HSA-2076383.md	HS3ST1 sulfates GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HS3ST1 sulfating GlcN at C3 in HS.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	27	R-HSA-2076392	Reactome pathway R-HSA-2076392	yes	reactome/R-HSA-2076392.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for EXT1:EXT2 GlcA transfer to heparan.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	28	R-HSA-2076419	Reactome pathway R-HSA-2076419	yes	reactome/R-HSA-2076419.md	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HS6STs sulfating GlcN at C6.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	29	R-HSA-2076508	Reactome pathway R-HSA-2076508	yes	reactome/R-HSA-2076508.md	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HS2ST1 trimer sulfating IdoA at C2.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	30	R-HSA-2076611	Reactome pathway R-HSA-2076611	yes	reactome/R-HSA-2076611.md	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HS3ST2-6 sulfating GlcN at C3.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	31	R-HSA-3560802	Reactome pathway R-HSA-3560802	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective B3GAT3 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	32	R-HSA-3656254	Reactome pathway R-HSA-3656254	yes	reactome/R-HSA-3656254.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT2 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	33	R-HSA-3656257	Reactome pathway R-HSA-3656257	yes	reactome/R-HSA-3656257.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT1 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	34	R-HSA-3656261	Reactome pathway R-HSA-3656261	yes	reactome/R-HSA-3656261.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT1 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	35	R-HSA-3656267	Reactome pathway R-HSA-3656267	yes	reactome/R-HSA-3656267.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT2 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	36	R-HSA-1678694	Reactome pathway R-HSA-1678694	yes	reactome/R-HSA-1678694.md	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for Heparanase 2 (HPSE2) binding to HSPGs at plasma membrane.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	37	R-HSA-2024084	Reactome pathway R-HSA-2024084	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for HS-GAG translocation to lysosome for degradation.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	38	R-HSA-2024108	Reactome pathway R-HSA-2024108	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for HSPG secretion to plasma membrane.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	39	R-HSA-2404131	Reactome pathway R-HSA-2404131	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for LRP-mediated transport of retinoid esters with HSPG and apoE.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	40	R-HSA-2423785	Reactome pathway R-HSA-2423785	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for retinoid esters binding apoE and HSPG.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	41	R-HSA-2429643	Reactome pathway R-HSA-2429643	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for NREH hydrolysis of retinoid esters.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	42	R-HSA-9694579	Reactome pathway R-HSA-9694579	yes	reactome/R-HSA-9694579.md	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for SARS-CoV-2 Spike binding ACE2. HSPGs can serve as attachment factors for viral entry.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	43	R-HSA-9694661	Reactome pathway R-HSA-9694661	yes	reactome/R-HSA-9694661.md	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for TMPRSS2-mediated SARS-CoV-2 entry.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	44	R-HSA-9698988	Reactome pathway R-HSA-9698988	yes	reactome/R-HSA-9698988.md	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for SARS-CoV-2 membrane fusion.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	45	R-HSA-9699007	Reactome pathway R-HSA-9699007	yes	reactome/R-HSA-9699007.md	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for FURIN-mediated SARS-CoV-2 entry.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	46	R-HSA-9836899	Reactome pathway R-HSA-9836899	yes	reactome/R-HSA-9836899.md	sG binds to HSPGs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for RSV sG binding to HSPGs.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	47	R-HSA-1667005	Reactome pathway R-HSA-1667005	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for heparanase cleaving HS in lysosome.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	48	R-HSA-2024084	Reactome pathway R-HSA-2024084	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for HS-GAG translocation to lysosome for degradation.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	49	R-HSA-1889981	Reactome pathway R-HSA-1889981	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for B4GALT7 transferring Gal to xylosyl-unit.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	50	R-HSA-3560804	Reactome pathway R-HSA-3560804	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective B4GALT7 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	52	R-HSA-9036285	Reactome pathway R-HSA-9036285	yes	reactome/R-HSA-9036285.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT1 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	53	R-HSA-9036289	Reactome pathway R-HSA-9036289	yes	reactome/R-HSA-9036289.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective EXT2 disease mechanism.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	54	R-HSA-9953259	Reactome pathway R-HSA-9953259	yes	reactome/R-HSA-9953259.md	EXTL3 dimer transfers GlcNAc to the GAG linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for EXTL3 dimer transferring GlcNAc to GAG linker.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	55	R-HSA-1667005	Reactome pathway R-HSA-1667005	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for heparanase cleaving HS in lysosome.
human	GPC6	genes/human/GPC6/GPC6-ai-review.yaml	GPC6	Q9Y625	NCBITaxon:9606	Homo sapiens	56	R-HSA-4420365	Reactome pathway R-HSA-4420365	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for defective B3GALT6 disease mechanism.
human	GPD1	genes/human/GPD1/GPD1-ai-review.yaml	GPD1	P21695	NCBITaxon:9606	Homo sapiens	13	R-HSA-75889	DHAP is converted to G3P by GPD1/GPD1L	yes	reactome/R-HSA-75889.md	DHAP is converted to G3P by GPD1/GPD1L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing GPD1 in the cytosol, where it catalyses the DHAP -> G3P reaction. Consistent with the enzyme's soluble cytoplasmic localization and its role as the cytosolic arm of the glycerol-3-phosphate shuttle.
human	GPD2	genes/human/GPD2/GPD2-ai-review.yaml	GPD2	P43304	NCBITaxon:9606	Homo sapiens	10	R-HSA-188467	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	yes	reactome/R-HSA-188467.md	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	Homo sapiens	GO:0006127	glycerol-3-phosphate shuttle	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation to the glycerol-phosphate shuttle, the core biological process of GPD2. Agrees with the IBA call for this term.
human	GPD2	genes/human/GPD2/GPD2-ai-review.yaml	GPD2	P43304	NCBITaxon:9606	Homo sapiens	12	R-HSA-188467	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	yes	reactome/R-HSA-188467.md	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	Homo sapiens	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation of the core catalytic activity, consistent with the experimental IDA and the UniProt catalytic activity.
human	GPD2	genes/human/GPD2/GPD2-ai-review.yaml	GPD2	P43304	NCBITaxon:9606	Homo sapiens	16	R-HSA-188467	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	yes	reactome/R-HSA-188467.md	Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation to the mitochondrial inner membrane, the specific and correct location for this inner-membrane flavoenzyme. Core location.
human	GPHN	genes/human/GPHN/GPHN-ai-review.yaml	GPHN	Q9NQX3	NCBITaxon:9606	Homo sapiens	63	R-HSA-947531	Molybdenum ion transfer onto molybdopterin	yes	reactome/R-HSA-947531.md	Molybdenum ion transfer onto molybdopterin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author-statement plasma-membrane localization; correct but generic relative to the specific postsynaptic-membrane term.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	32	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion (Gluconeogenesis pathway) that GPI participates in gluconeogenesis via the reversible G6P to F6P step.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	33	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion (Glycolysis pathway) placing GPI in canonical glycolysis.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	35	R-HSA-70471	GPI dimer isomerizes G6P	yes	reactome/R-HSA-70471.md	GPI dimer isomerizes G6P	Homo sapiens	GO:0004347	glucose-6-phosphate isomerase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion (GPI dimer isomerizes G6P) for the core catalytic activity.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	44	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable assertion placing GPI in the extracellular region via exocytosis of secretory granule lumen proteins (neutrophil degranulation).
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	45	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable assertion placing GPI in the extracellular region via exocytosis of ficolin-rich granule lumen proteins.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	46	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable assertion localizing GPI to the secretory granule lumen in the context of neutrophil degranulation.
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	47	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable assertion localizing GPI to the ficolin-1-rich granule lumen (neutrophil degranulation pathway).
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	55	R-HSA-70471	GPI dimer isomerizes G6P	yes	reactome/R-HSA-70471.md	GPI dimer isomerizes G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion localizing GPI to the cytosol (GPI dimer isomerizes G6P reaction).
human	GPI	genes/human/GPI/GPI-ai-review.yaml	GPI	P06744	NCBITaxon:9606	Homo sapiens	56	R-HSA-70475	GPI dimer isomerizes Fru(6)P to G6P	yes	reactome/R-HSA-70475.md	GPI dimer isomerizes Fru(6)P to G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion localizing GPI to the cytosol (GPI dimer isomerizes Fru(6)P to G6P reaction).
human	GPR25	genes/human/GPR25/GPR25-ai-review.yaml	GPR25	O00155	NCBITaxon:9606	Homo sapiens	24	R-HSA-379044	Reactome pathway annotation placing GPR25 at the plasma membrane	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome placement of GPR25 at the plasma membrane in a peptide ligand-binding receptor pathway.
human	GPR25	genes/human/GPR25/GPR25-ai-review.yaml	GPR25	O00155	NCBITaxon:9606	Homo sapiens	25	R-HSA-744886	Reactome pathway annotation placing GPR25 at the plasma membrane	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome placement of GPR25 at the plasma membrane.
human	GPR25	genes/human/GPR25/GPR25-ai-review.yaml	GPR25	O00155	NCBITaxon:9606	Homo sapiens	26	R-HSA-744887	Reactome pathway annotation placing GPR25 at the plasma membrane	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome placement of GPR25 at the plasma membrane.
human	GPR37	genes/human/GPR37/GPR37-ai-review.yaml	GPR37	O15354	NCBITaxon:9606	Homo sapiens	51	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localisation asserted by a Reactome reaction in which GPR37 acts as a liganded Gi-activating GPCR.
human	GPR37	genes/human/GPR37/GPR37-ai-review.yaml	GPR37	O15354	NCBITaxon:9606	Homo sapiens	52	R-HSA-5336182	GPR37 binds prosaptide	yes	reactome/R-HSA-5336182.md	GPR37 binds prosaptide	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localisation asserted by a Reactome reaction in which GPR37 acts as a liganded Gi-activating GPCR.
human	GPR37	genes/human/GPR37/GPR37-ai-review.yaml	GPR37	O15354	NCBITaxon:9606	Homo sapiens	53	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localisation asserted by a Reactome reaction in which GPR37 acts as a liganded Gi-activating GPCR.
human	GPR37	genes/human/GPR37/GPR37-ai-review.yaml	GPR37	O15354	NCBITaxon:9606	Homo sapiens	54	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localisation asserted by a Reactome reaction in which GPR37 acts as a liganded Gi-activating GPCR.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	22	R-HSA-9018676	Biosynthesis of D-series resolvins	yes	reactome/R-HSA-9018676.md	Biosynthesis of D-series resolvins	Homo sapiens	GO:0042759	long-chain fatty acid biosynthetic process	TAS	involved_in	BP	false		MODIFY	"This annotation comes from Reactome pathway ""Biosynthesis of D-series resolvins."" GPX4 reduces 17-HpDHA to 17-HDHA in resolvin biosynthesis."
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	23	R-HSA-9018896	Biosynthesis of E-series 18(S)-resolvins	yes	reactome/R-HSA-9018896.md	Biosynthesis of E-series 18(S)-resolvins	Homo sapiens	GO:0042759	long-chain fatty acid biosynthetic process	TAS	involved_in	BP	false		MODIFY	Duplicate annotation from Reactome pathway for E-series resolvins.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	24	R-HSA-9020265	Biosynthesis of aspirin-triggered D-series resolvins	yes	reactome/R-HSA-9020265.md	Biosynthesis of aspirin-triggered D-series resolvins	Homo sapiens	GO:0042759	long-chain fatty acid biosynthetic process	TAS	involved_in	BP	false		MODIFY	Duplicate annotation from Reactome pathway for aspirin-triggered D-series resolvins.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	25	R-HSA-9023661	Biosynthesis of E-series 18(R)-resolvins	yes	reactome/R-HSA-9023661.md	Biosynthesis of E-series 18(R)-resolvins	Homo sapiens	GO:0042759	long-chain fatty acid biosynthetic process	TAS	involved_in	BP	false		MODIFY	Duplicate annotation from Reactome pathway for E-series 18(R)-resolvins.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	26	R-HSA-9018868	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE	yes	reactome/R-HSA-9018868.md	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE	Homo sapiens	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction showing GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	27	R-HSA-9018895	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE	yes	reactome/R-HSA-9018895.md	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE	Homo sapiens	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction showing GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	28	R-HSA-9020271	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA	yes	reactome/R-HSA-9020271.md	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA	Homo sapiens	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction showing GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	29	R-HSA-9020273	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA	yes	reactome/R-HSA-9020273.md	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA	Homo sapiens	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction showing GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	35	R-HSA-2161959	12R-HpETE is reduced to 12R-HETE by GPX1/2/4	yes	reactome/R-HSA-2161959.md	12R-HpETE is reduced to 12R-HETE by GPX1/2/4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction for 12R-HpETE reduction to 12R-HETE by GPX1/2/4 places the activity in the cytosol.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	36	R-HSA-2161999	12S-HpETE is reduced to 12S-HETE by GPX1/2/4	yes	reactome/R-HSA-2161999.md	12S-HpETE is reduced to 12S-HETE by GPX1/2/4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for 12S-HpETE reduction.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	41	R-HSA-9018868	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE	yes	reactome/R-HSA-9018868.md	GPX4-2 reduces 18(S)-HpEPE to 18(S)-HEPE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction placing GPX4 activity in cytosol for resolvin biosynthesis.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	42	R-HSA-9018895	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE	yes	reactome/R-HSA-9018895.md	GPX4-2 reduces 18(R)-HpEPE to 18(R)-HEPE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosolic localization.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	43	R-HSA-9020271	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA	yes	reactome/R-HSA-9020271.md	GPX4-2 reduces 17(R)-Hp-DHA to 17(R)-HDHA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosolic localization.
human	GPX4	genes/human/GPX4/GPX4-ai-review.yaml	GPX4	P36969	NCBITaxon:9606	Homo sapiens	44	R-HSA-9020273	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA	yes	reactome/R-HSA-9020273.md	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for cytosolic localization.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	590	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	591	R-HSA-109813	GRB2-1 binds SOS1	yes	reactome/R-HSA-109813.md	GRB2-1 binds SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	592	R-HSA-109822	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1	yes	reactome/R-HSA-109822.md	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	593	R-HSA-109823	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2	yes	reactome/R-HSA-109823.md	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	594	R-HSA-1225950	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	yes	reactome/R-HSA-1225950.md	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	595	R-HSA-1225951	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	596	R-HSA-1225957	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	597	R-HSA-1225961	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	yes	reactome/R-HSA-1225961.md	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	598	R-HSA-1226012	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226012.md	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	599	R-HSA-1226014	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226014.md	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	600	R-HSA-1226016	Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226016.md	Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	601	R-HSA-1250380	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers	yes	reactome/R-HSA-1250380.md	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	602	R-HSA-1250383	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	yes	reactome/R-HSA-1250383.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	603	R-HSA-1295613	SPRY2 binds GRB2	yes	reactome/R-HSA-1295613.md	SPRY2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	604	R-HSA-1306957	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306957.md	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	605	R-HSA-1306963	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR	yes	reactome/R-HSA-1306963.md	Binding of GRB2:GAB1 to p-ERBB2:p-EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	606	R-HSA-1306965	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306965.md	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	607	R-HSA-1306969	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306969.md	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	608	R-HSA-1306972	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306972.md	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	609	R-HSA-1433428	GRB2 is indirectly recruited to p-KIT through SHP2	yes	reactome/R-HSA-1433428.md	GRB2 is indirectly recruited to p-KIT through SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	610	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	yes	reactome/R-HSA-1433454.md	Phosphorylation of GAB2 by SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	611	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	612	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	613	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	614	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	615	R-HSA-177920	Binding of GRB2 to GAB1	yes	reactome/R-HSA-177920.md	Binding of GRB2 to GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	616	R-HSA-177923	Sustained activation of SRC kinase by SHP2	yes	reactome/R-HSA-177923.md	Sustained activation of SRC kinase by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	617	R-HSA-177924	Dephosphorylation of Gab1 by SHP2	yes	reactome/R-HSA-177924.md	Dephosphorylation of Gab1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	618	R-HSA-177926	Dephosphorylation of PAG by SHP2	yes	reactome/R-HSA-177926.md	Dephosphorylation of PAG by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	619	R-HSA-177927	PI3K binds to EGF:EGFR:GRB2:GAB1	yes	reactome/R-HSA-177927.md	PI3K binds to EGF:EGFR:GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	620	R-HSA-177930	GAB1 phosphorylation by EGFR kinase	yes	reactome/R-HSA-177930.md	GAB1 phosphorylation by EGFR kinase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	621	R-HSA-177931	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1	yes	reactome/R-HSA-177931.md	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	622	R-HSA-177935	SHP2 dephosphorylates Tyr 992 on EGFR	yes	reactome/R-HSA-177935.md	SHP2 dephosphorylates Tyr 992 on EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	623	R-HSA-177936	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	yes	reactome/R-HSA-177936.md	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	624	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	625	R-HSA-177939	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	yes	reactome/R-HSA-177939.md	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	626	R-HSA-177941	GRB2:GAB1 binds to phosphorylated EGFR	yes	reactome/R-HSA-177941.md	GRB2:GAB1 binds to phosphorylated EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	627	R-HSA-177943	GRB2:SOS1 complex binds to EGF:EGFR complex	yes	reactome/R-HSA-177943.md	GRB2:SOS1 complex binds to EGF:EGFR complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	628	R-HSA-177944	Activation of SHP2 through the binding to phospho-Gab1	yes	reactome/R-HSA-177944.md	Activation of SHP2 through the binding to phospho-Gab1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	629	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	630	R-HSA-179467	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate	yes	reactome/R-HSA-179467.md	GAB1 binds phosphatidylinositol-3,4,5-trisphosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	631	R-HSA-182994	Assembly of EGFR complex in clathrin-coated vesicles	yes	reactome/R-HSA-182994.md	Assembly of EGFR complex in clathrin-coated vesicles	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	632	R-HSA-183002	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85	yes	reactome/R-HSA-183002.md	Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	633	R-HSA-183036	Ubiquitination of stimulated EGFR (CBL:GRB2)	yes	reactome/R-HSA-183036.md	Ubiquitination of stimulated EGFR (CBL:GRB2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	634	R-HSA-183052	CBL binds to GRB2	yes	reactome/R-HSA-183052.md	CBL binds to GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	635	R-HSA-183058	Phosphorylation of CBL (EGFR:GRB2:CBL)	yes	reactome/R-HSA-183058.md	Phosphorylation of CBL (EGFR:GRB2:CBL)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	636	R-HSA-183067	Localization of CBL:GRB2 to the membrane	yes	reactome/R-HSA-183067.md	Localization of CBL:GRB2 to the membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	637	R-HSA-183084	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix	yes	reactome/R-HSA-183084.md	CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	638	R-HSA-1839095	p-BCR-pFGFR1 binds GRB2:GAB2	yes	reactome/R-HSA-1839095.md	p-BCR-pFGFR1 binds GRB2:GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	639	R-HSA-1839102	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-1839102.md	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	640	R-HSA-1839107	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-1839107.md	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	641	R-HSA-1839110	p-BCR-p-FGFR1 phosphorylates GAB2	yes	reactome/R-HSA-1839110.md	p-BCR-p-FGFR1 phosphorylates GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	642	R-HSA-1839114	BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1	yes	reactome/R-HSA-1839114.md	BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	643	R-HSA-186826	GRB2:SOS1 complex binds to the active receptor	yes	reactome/R-HSA-186826.md	GRB2:SOS1 complex binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	644	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	645	R-HSA-2029466	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	yes	reactome/R-HSA-2029466.md	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	646	R-HSA-204871	Interaction of Tie2 and Grb2	yes	reactome/R-HSA-204871.md	Interaction of Tie2 and Grb2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	647	R-HSA-205234	Indirect recruitment of GAB2 to p-KIT	yes	reactome/R-HSA-205234.md	Indirect recruitment of GAB2 to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	648	R-HSA-205244	Recruitment of CBL to KIT	yes	reactome/R-HSA-205244.md	Recruitment of CBL to KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	649	R-HSA-205286	GRB2:SOS interacts with p-KIT	yes	reactome/R-HSA-205286.md	GRB2:SOS interacts with p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	650	R-HSA-210974	Interaction of SOS-1 to Tie2 bound Grb2	yes	reactome/R-HSA-210974.md	Interaction of SOS-1 to Tie2 bound Grb2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	651	R-HSA-210977	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	652	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	653	R-HSA-2179415	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	yes	reactome/R-HSA-2179415.md	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	654	R-HSA-2197690	Detachment of WASP/WAVE	yes	reactome/R-HSA-2197690.md	Detachment of WASP/WAVE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	655	R-HSA-2197691	WIP binds WASP,N-WASP, activating them	yes	reactome/R-HSA-2197691.md	WIP binds WASP,N-WASP, activating them	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	656	R-HSA-2197698	Src phosphorylate WASP,N-WASP	yes	reactome/R-HSA-2197698.md	Src phosphorylate WASP,N-WASP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	657	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	658	R-HSA-2396561	Recruitment of GADS:SLP-76 to p-5Y-LAT	yes	reactome/R-HSA-2396561.md	Recruitment of GADS:SLP-76 to p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	659	R-HSA-2396594	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2396594.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	660	R-HSA-2396599	Recruitment of GRB2:SOS to p-5Y-LAT	yes	reactome/R-HSA-2396599.md	Recruitment of GRB2:SOS to p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	661	R-HSA-2396606	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	yes	reactome/R-HSA-2396606.md	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	662	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	663	R-HSA-2424476	Activation of RAC1 by VAV2/3	yes	reactome/R-HSA-2424476.md	Activation of RAC1 by VAV2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	664	R-HSA-2424477	SOS mediated nucleotide exchange of RAS (SHC)	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	665	R-HSA-2424481	Recruitment of VAV and BTK to p-SLP-76	yes	reactome/R-HSA-2424481.md	Recruitment of VAV and BTK to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	666	R-HSA-2424484	Phosphorylation of BTK by p-SYK	yes	reactome/R-HSA-2424484.md	Phosphorylation of BTK by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	667	R-HSA-2424485	Release of p-PLCG1	yes	reactome/R-HSA-2424485.md	Release of p-PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	668	R-HSA-2424486	Phosphorylation and activation of VAV2/VAV3 by SYK	yes	reactome/R-HSA-2424486.md	Phosphorylation and activation of VAV2/VAV3 by SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	669	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	yes	reactome/R-HSA-2424487.md	Phosphorylation of PLC-gamma by p-BTK/p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	670	R-HSA-2730833	Phosphorylation of TEC kinases by p-SYK	yes	reactome/R-HSA-2730833.md	Phosphorylation of TEC kinases by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	671	R-HSA-2730837	Recruitment of GRB2:SOS to p-10Y-NTAL	yes	reactome/R-HSA-2730837.md	Recruitment of GRB2:SOS to p-10Y-NTAL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	672	R-HSA-2730840	Activation of RAC1 by VAV	yes	reactome/R-HSA-2730840.md	Activation of RAC1 by VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	673	R-HSA-2730841	Phosphorylation and activation of VAV	yes	reactome/R-HSA-2730841.md	Phosphorylation and activation of VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	674	R-HSA-2730842	PI3K associates with phosphorylated GAB2	yes	reactome/R-HSA-2730842.md	PI3K associates with phosphorylated GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	675	R-HSA-2730844	Interaction of GRB2:SOS complex with p-SHC1	yes	reactome/R-HSA-2730844.md	Interaction of GRB2:SOS complex with p-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	676	R-HSA-2730847	Hydrolysis of PIP2 by PLCG	yes	reactome/R-HSA-2730847.md	Hydrolysis of PIP2 by PLCG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	677	R-HSA-2730851	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2730851.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	678	R-HSA-2730856	Autophosphorylation of PAK	yes	reactome/R-HSA-2730856.md	Autophosphorylation of PAK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	679	R-HSA-2730858	Autophosphorylation of BTK/ITK	yes	reactome/R-HSA-2730858.md	Autophosphorylation of BTK/ITK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	680	R-HSA-2730870	Phosphorylation of PIP2 to PIP3 by PI3K	yes	reactome/R-HSA-2730870.md	Phosphorylation of PIP2 to PIP3 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	681	R-HSA-2730889	Recruitment of PAK to the membrane by binding active RAC1	yes	reactome/R-HSA-2730889.md	Recruitment of PAK to the membrane by binding active RAC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	682	R-HSA-2730892	Recruitment of VAV to p-SLP-76	yes	reactome/R-HSA-2730892.md	Recruitment of VAV to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	683	R-HSA-354087	Recruitment of GRB2 to p-PTK2	yes	reactome/R-HSA-354087.md	Recruitment of GRB2 to p-PTK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	684	R-HSA-354165	Interaction of SOS with GRB2 bound to FADK1	yes	reactome/R-HSA-354165.md	Interaction of SOS with GRB2 bound to FADK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	685	R-HSA-388814	Grb2 binds CD28	yes	reactome/R-HSA-388814.md	Grb2 binds CD28	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	686	R-HSA-389348	Activation of Rac1 by pVav1	yes	reactome/R-HSA-389348.md	Activation of Rac1 by pVav1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	687	R-HSA-389350	Activation of Cdc42 by pVav1	yes	reactome/R-HSA-389350.md	Activation of Cdc42 by pVav1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	688	R-HSA-389352	Translocation of Vav1 to CD28	yes	reactome/R-HSA-389352.md	Translocation of Vav1 to CD28	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	689	R-HSA-389354	Activation of Vav1	yes	reactome/R-HSA-389354.md	Activation of Vav1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	690	R-HSA-389919	Grb2 binds pBTLA	yes	reactome/R-HSA-389919.md	Grb2 binds pBTLA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	691	R-HSA-391153	p-4Y-SIRPA:CD47 binds GRB2-1	yes	reactome/R-HSA-391153.md	p-4Y-SIRPA:CD47 binds GRB2-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	692	R-HSA-392051	Recruitment of Grb2 to pFAK:NCAM1	yes	reactome/R-HSA-392051.md	Recruitment of Grb2 to pFAK:NCAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	693	R-HSA-392053	SOS binds Grb2 bound to pFAK:NCAM1	yes	reactome/R-HSA-392053.md	SOS binds Grb2 bound to pFAK:NCAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	694	R-HSA-392054	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	695	R-HSA-453104	Phosphorylated SHC1 recruits GRB2:GAB2	yes	reactome/R-HSA-453104.md	Phosphorylated SHC1 recruits GRB2:GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	696	R-HSA-453111	Phosphorylated SHC recruits GRB2:SOS1	yes	reactome/R-HSA-453111.md	Phosphorylated SHC recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	697	R-HSA-508247	Gab2 binds the p85 subunit of Class 1A PI3 kinases	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	698	R-HSA-5637764	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant	yes	reactome/R-HSA-5637764.md	Binding of GRB2:GAB1 complex to p-EGFRvIII mutant	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	699	R-HSA-5637765	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	yes	reactome/R-HSA-5637765.md	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	700	R-HSA-5637770	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637770.md	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	701	R-HSA-5637798	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	yes	reactome/R-HSA-5637798.md	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	702	R-HSA-5637801	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637801.md	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	703	R-HSA-5637806	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	704	R-HSA-5637808	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	705	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	706	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	707	R-HSA-5654406	Activated FGFR2:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654406.md	Activated FGFR2:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	708	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	709	R-HSA-5654416	Activated FGFR3:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654416.md	Activated FGFR3:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	710	R-HSA-5654423	Activated FGFR4:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654423.md	Activated FGFR4:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	711	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	712	R-HSA-5654586	Activated FGFR1:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654586.md	Activated FGFR1:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	713	R-HSA-5654591	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654591.md	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	714	R-HSA-5654592	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654592.md	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	715	R-HSA-5654594	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654594.md	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	716	R-HSA-5654596	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654596.md	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	717	R-HSA-5654597	Activated FGFR1:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654597.md	Activated FGFR1:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	718	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	719	R-HSA-5654612	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654612.md	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	720	R-HSA-5654614	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654614.md	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	721	R-HSA-5654615	Activated FGFR2:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654615.md	Activated FGFR2:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	722	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	723	R-HSA-5654620	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654620.md	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	724	R-HSA-5654622	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	725	R-HSA-5654637	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654637.md	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	726	R-HSA-5654640	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654640.md	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	727	R-HSA-5654641	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654641.md	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	728	R-HSA-5654643	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654643.md	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	729	R-HSA-5654646	Activated FGFR3:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654646.md	Activated FGFR3:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	730	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	731	R-HSA-5654659	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654659.md	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	732	R-HSA-5654662	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654662.md	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	733	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	734	R-HSA-5654664	Activated FGFR4:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654664.md	Activated FGFR4:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	735	R-HSA-5654667	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654667.md	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	736	R-HSA-5654669	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	737	R-HSA-5654672	CBL ubiquitinates FRS2 and FGFR1	yes	reactome/R-HSA-5654672.md	CBL ubiquitinates FRS2 and FGFR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	738	R-HSA-5654673	p-CBL:GRB2 binds p-FRS2:activated FGFR1	yes	reactome/R-HSA-5654673.md	p-CBL:GRB2 binds p-FRS2:activated FGFR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	739	R-HSA-5654677	CBL ubiquitinates FRS2 and FGFR2	yes	reactome/R-HSA-5654677.md	CBL ubiquitinates FRS2 and FGFR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	740	R-HSA-5654679	CBL ubiquitinates FRS2 and FGFR3	yes	reactome/R-HSA-5654679.md	CBL ubiquitinates FRS2 and FGFR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	741	R-HSA-5654684	CBL ubiquitinates FRS2 and FGFR4	yes	reactome/R-HSA-5654684.md	CBL ubiquitinates FRS2 and FGFR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	742	R-HSA-5654690	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654690.md	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	743	R-HSA-5654692	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654692.md	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	744	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	745	R-HSA-5654701	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654701.md	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	746	R-HSA-5654705	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654705.md	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	747	R-HSA-5654709	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654709.md	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	748	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	749	R-HSA-5654717	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654717.md	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	750	R-HSA-5654729	p-CBL:GRB2 binds p-FRS2:activated FGFR2	yes	reactome/R-HSA-5654729.md	p-CBL:GRB2 binds p-FRS2:activated FGFR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	751	R-HSA-5654730	p-CBL:GRB2 binds p-FRS2:activated FGFR3	yes	reactome/R-HSA-5654730.md	p-CBL:GRB2 binds p-FRS2:activated FGFR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	752	R-HSA-5654734	p-CBL:GRB2 binds p-FRS2:activated FGFR4	yes	reactome/R-HSA-5654734.md	p-CBL:GRB2 binds p-FRS2:activated FGFR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	753	R-HSA-5655233	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655233.md	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	754	R-HSA-5655235	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655235.md	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	755	R-HSA-5655240	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655240.md	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	756	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	757	R-HSA-5655245	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655245.md	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	758	R-HSA-5655248	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655248.md	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	759	R-HSA-5655252	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655252.md	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	760	R-HSA-5655263	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655263.md	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	761	R-HSA-5655266	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655266.md	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	762	R-HSA-5655277	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	763	R-HSA-5655285	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655285.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	764	R-HSA-5655289	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655289.md	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	765	R-HSA-5655290	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	766	R-HSA-5655295	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655295.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	767	R-HSA-5655315	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655315.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	768	R-HSA-5655320	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5655320.md	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	769	R-HSA-5655323	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	770	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	771	R-HSA-5655347	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655347.md	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	772	R-HSA-5655348	Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655348.md	Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	773	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	774	R-HSA-5685366	GRB2-1:SOS1 binds p-Y-SHC	yes	reactome/R-HSA-5685366.md	GRB2-1:SOS1 binds p-Y-SHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	775	R-HSA-5686073	GRB2-1:SOS1 binds p-3Y-SHC1	yes	reactome/R-HSA-5686073.md	GRB2-1:SOS1 binds p-3Y-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	776	R-HSA-5686074	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates	yes	reactome/R-HSA-5686074.md	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	777	R-HSA-5686315	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates	yes	reactome/R-HSA-5686315.md	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	778	R-HSA-74736	GRB2-1:SOS1 binds p-IRS1,p-IRS2	yes	reactome/R-HSA-74736.md	GRB2-1:SOS1 binds p-IRS1,p-IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	779	R-HSA-74746	GRB2-1:SOS1 binds p-Y427-SHC1	yes	reactome/R-HSA-74746.md	GRB2-1:SOS1 binds p-Y427-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	780	R-HSA-879917	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	yes	reactome/R-HSA-879917.md	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	781	R-HSA-8851804	Activated MET recruits GRB2-1:SOS1	yes	reactome/R-HSA-8851804.md	Activated MET recruits GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	782	R-HSA-8851827	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	yes	reactome/R-HSA-8851827.md	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	783	R-HSA-8851899	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	yes	reactome/R-HSA-8851899.md	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	784	R-HSA-8851900	SHC1-2 bound to MET recruits GRB2:SOS1	yes	reactome/R-HSA-8851900.md	SHC1-2 bound to MET recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	785	R-HSA-8851919	Activated MET binds GAB1 and GRB2	yes	reactome/R-HSA-8851919.md	Activated MET binds GAB1 and GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	786	R-HSA-8851933	MET phosphorylates GAB1	yes	reactome/R-HSA-8851933.md	MET phosphorylates GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	787	R-HSA-8851954	Phosphorylated GAB1 recruits PI3K to MET	yes	reactome/R-HSA-8851954.md	Phosphorylated GAB1 recruits PI3K to MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	788	R-HSA-8852019	MET bound PI3K generates PIP3	yes	reactome/R-HSA-8852019.md	MET bound PI3K generates PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	789	R-HSA-8853734	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1	yes	reactome/R-HSA-8853734.md	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	790	R-HSA-8853774	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated	yes	reactome/R-HSA-8853774.md	GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	791	R-HSA-8853793	p-5Y-RET complexes bind GRB2	yes	reactome/R-HSA-8853793.md	p-5Y-RET complexes bind GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	792	R-HSA-8854897	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2	yes	reactome/R-HSA-8854897.md	p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	793	R-HSA-8854899	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1	yes	reactome/R-HSA-8854899.md	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	794	R-HSA-8854905	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	yes	reactome/R-HSA-8854905.md	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	795	R-HSA-8855508	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11	yes	reactome/R-HSA-8855508.md	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	796	R-HSA-8865994	GAB1 binds PTPN11	yes	reactome/R-HSA-8865994.md	GAB1 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	797	R-HSA-8866279	Epsin family proteins bind ubiquitinated cargo	yes	reactome/R-HSA-8866279.md	Epsin family proteins bind ubiquitinated cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	798	R-HSA-8867041	EGFR phosphorylates EPS15	yes	reactome/R-HSA-8867041.md	EGFR phosphorylates EPS15	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	799	R-HSA-8867044	EGFR binds EPS15, EPN1, EPS15L1	yes	reactome/R-HSA-8867044.md	EGFR binds EPS15, EPN1, EPS15L1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	800	R-HSA-8867047	PTPN3 dephosphorylates EPS15	yes	reactome/R-HSA-8867047.md	PTPN3 dephosphorylates EPS15	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	801	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	802	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	803	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	804	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	805	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	806	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	807	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	808	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	809	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	810	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	811	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	812	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	813	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	814	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	815	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	816	R-HSA-8874685	CBL binds MET	yes	reactome/R-HSA-8874685.md	CBL binds MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	817	R-HSA-8875183	CBL monoubiquitinates activated MET	yes	reactome/R-HSA-8875183.md	CBL monoubiquitinates activated MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	818	R-HSA-8875451	MET phosphorylates CBL	yes	reactome/R-HSA-8875451.md	MET phosphorylates CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	819	R-HSA-8875482	CBL recruits CIN85:endophilin to ubiquitinated MET	yes	reactome/R-HSA-8875482.md	CBL recruits CIN85:endophilin to ubiquitinated MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	820	R-HSA-8875490	EPS15 and HGS bind ubiquitinated MET	yes	reactome/R-HSA-8875490.md	EPS15 and HGS bind ubiquitinated MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	821	R-HSA-8875540	GAB1 recruits CRK,CRKL to MET	yes	reactome/R-HSA-8875540.md	GAB1 recruits CRK,CRKL to MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	822	R-HSA-8875558	RAPGEF1 binds CRK,CRKL	yes	reactome/R-HSA-8875558.md	RAPGEF1 binds CRK,CRKL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	823	R-HSA-8875568	RAPGEF1 activates RAP1	yes	reactome/R-HSA-8875568.md	RAPGEF1 activates RAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	824	R-HSA-8875576	CRK,CRKL recruits RAC1 GEF to activated MET	yes	reactome/R-HSA-8875576.md	CRK,CRKL recruits RAC1 GEF to activated MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	825	R-HSA-8875591	DOCK7 activates RAC1	yes	reactome/R-HSA-8875591.md	DOCK7 activates RAC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	826	R-HSA-8875659	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane	yes	reactome/R-HSA-8875659.md	RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	827	R-HSA-8875661	GGA3 associates with activated MET receptor	yes	reactome/R-HSA-8875661.md	GGA3 associates with activated MET receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	828	R-HSA-8876240	CBL binds InlB-activated MET	yes	reactome/R-HSA-8876240.md	CBL binds InlB-activated MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	829	R-HSA-8876258	CBL monoubiquitinates InlB-bound MET	yes	reactome/R-HSA-8876258.md	CBL monoubiquitinates InlB-bound MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	830	R-HSA-8951490	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85	yes	reactome/R-HSA-8951490.md	CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	831	R-HSA-8983384	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	yes	reactome/R-HSA-8983384.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	832	R-HSA-9018766	RHOU binds effectors at the plasma membrane	yes	reactome/R-HSA-9018766.md	RHOU binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	833	R-HSA-9029150	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1	yes	reactome/R-HSA-9029150.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	834	R-HSA-9032073	NTRK2-phosphorylated FRS2 binds GRB2	yes	reactome/R-HSA-9032073.md	NTRK2-phosphorylated FRS2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	835	R-HSA-912527	SHC1 mediates cytokine-induced phosphorylation of GAB2	yes	reactome/R-HSA-912527.md	SHC1 mediates cytokine-induced phosphorylation of GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	836	R-HSA-912627	CBL ubiquitinates PI3K	yes	reactome/R-HSA-912627.md	CBL ubiquitinates PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	837	R-HSA-913424	The SHC1:SHIP1 complex is stabilized by GRB2	yes	reactome/R-HSA-913424.md	The SHC1:SHIP1 complex is stabilized by GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	838	R-HSA-9606887	p-CD19:VAV binds PI3K and GRB2	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	839	R-HSA-9607301	Active FLT3:GRB2 binds SOS1	yes	reactome/R-HSA-9607301.md	Active FLT3:GRB2 binds SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	840	R-HSA-9607304	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	841	R-HSA-9634402	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer	yes	reactome/R-HSA-9634402.md	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	842	R-HSA-9634418	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	yes	reactome/R-HSA-9634418.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	843	R-HSA-9664918	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1	yes	reactome/R-HSA-9664918.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	844	R-HSA-9664933	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9664933.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	845	R-HSA-9664940	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9664940.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	846	R-HSA-9664983	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9664983.md	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	847	R-HSA-9664991	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	848	R-HSA-9665000	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665000.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	849	R-HSA-9665009	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	850	R-HSA-9665404	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	851	R-HSA-9665407	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9665407.md	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	852	R-HSA-9665408	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	853	R-HSA-9665409	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	yes	reactome/R-HSA-9665409.md	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	854	R-HSA-9665413	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665413.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	855	R-HSA-9665415	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9665415.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	856	R-HSA-9665417	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1	yes	reactome/R-HSA-9665417.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	857	R-HSA-9665698	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665698.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	858	R-HSA-9665699	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665699.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	859	R-HSA-9665700	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	860	R-HSA-9665707	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	861	R-HSA-9670428	KIT mutants bind GRB2-SOS	yes	reactome/R-HSA-9670428.md	KIT mutants bind GRB2-SOS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	862	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	863	R-HSA-9672158	GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672158.md	GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	864	R-HSA-9672163	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672163.md	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	865	R-HSA-9672164	GRB2:SOS1 complex binds to mutant PDGFR receptor	yes	reactome/R-HSA-9672164.md	GRB2:SOS1 complex binds to mutant PDGFR receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	866	R-HSA-9672170	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	867	R-HSA-9674816	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	yes	reactome/R-HSA-9674816.md	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	868	R-HSA-9695841	FLT3 mutant dimers bind GRB2	yes	reactome/R-HSA-9695841.md	FLT3 mutant dimers bind GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	869	R-HSA-9695845	FLT3 mutant dimers:GRB2 bind SOS1	yes	reactome/R-HSA-9695845.md	FLT3 mutant dimers:GRB2 bind SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	870	R-HSA-9695853	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	871	R-HSA-9698000	FLT3 mutants:GRB2 bind GAB2	yes	reactome/R-HSA-9698000.md	FLT3 mutants:GRB2 bind GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	872	R-HSA-9698003	FLT3 mutants phosphorylate GAB2	yes	reactome/R-HSA-9698003.md	FLT3 mutants phosphorylate GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	873	R-HSA-9698005	FLT3 ITD mutants phosphorylate STAT5	yes	reactome/R-HSA-9698005.md	FLT3 ITD mutants phosphorylate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	874	R-HSA-9698007	FLT3 ITD mutants bind STAT5 through GAB2:PTPN11	yes	reactome/R-HSA-9698007.md	FLT3 ITD mutants bind STAT5 through GAB2:PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	875	R-HSA-9698008	FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11	yes	reactome/R-HSA-9698008.md	FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	876	R-HSA-9698013	PTPN11:p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698013.md	PTPN11:p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	877	R-HSA-9698029	p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698029.md	p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	878	R-HSA-9698170	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-9698170.md	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	879	R-HSA-9698174	FLT3 mutants recruit PIK3CA through PIK3R1	yes	reactome/R-HSA-9698174.md	FLT3 mutants recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	880	R-HSA-9703430	FLT3 fusions:GRB2 bind SOS1	yes	reactome/R-HSA-9703430.md	FLT3 fusions:GRB2 bind SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	881	R-HSA-9703434	FLT3 fusions recruit PIK3CA through PIK3R1	yes	reactome/R-HSA-9703434.md	FLT3 fusions recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	882	R-HSA-9703438	FLT3 fusions phosphorylate GAB2	yes	reactome/R-HSA-9703438.md	FLT3 fusions phosphorylate GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	883	R-HSA-9703441	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	884	R-HSA-9710914	ALK fusions bind GRB2	yes	reactome/R-HSA-9710914.md	ALK fusions bind GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	885	R-HSA-9724099	ALK mutants:p-3Y SHC binds GRB2	yes	reactome/R-HSA-9724099.md	ALK mutants:p-3Y SHC binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	886	R-HSA-983703	p-6Y-SYK phosphorylates BLNK (SLP65)	yes	reactome/R-HSA-983703.md	p-6Y-SYK phosphorylates BLNK (SLP65)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	887	R-HSA-9842655	IRS1 recruits GRB2 to active LTK	yes	reactome/R-HSA-9842655.md	IRS1 recruits GRB2 to active LTK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	888	R-HSA-9842665	Active LTK binds GRB2:TNK2	yes	reactome/R-HSA-9842665.md	Active LTK binds GRB2:TNK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	889	R-HSA-9842669	Active LTK recruits GRB2:SOS1	yes	reactome/R-HSA-9842669.md	Active LTK recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	890	R-NUL-1250468	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	yes	reactome/R-NUL-1250468.md	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	891	R-NUL-1250472	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	yes	reactome/R-NUL-1250472.md	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	892	R-NUL-1250475	Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer	yes	reactome/R-NUL-1250475.md	Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	893	R-NUL-1250500	Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex	yes	reactome/R-NUL-1250500.md	Recruitment of GRB2:Sos1 to P-Shc1:P-Erbb2mut complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	896	R-HSA-1112666	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	yes	reactome/R-HSA-1112666.md	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	897	R-HSA-2076220	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	yes	reactome/R-HSA-2076220.md	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	898	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	899	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	900	R-HSA-9606151	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	yes	reactome/R-HSA-9606151.md	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	901	R-HSA-9606887	p-CD19:VAV binds PI3K and GRB2	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	902	R-HSA-9691421	BTK binds BTK inhibitors	yes	reactome/R-HSA-9691421.md	BTK binds BTK inhibitors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRB2	genes/human/GRB2/GRB2-ai-review.yaml	GRB2	P62993	NCBITaxon:9606	Homo sapiens	903	R-HSA-983703	p-6Y-SYK phosphorylates BLNK (SLP65)	yes	reactome/R-HSA-983703.md	p-6Y-SYK phosphorylates BLNK (SLP65)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome): plasma membrane localization within signaling events.
human	GRHPR	genes/human/GRHPR/GRHPR-ai-review.yaml	GRHPR	Q9UBQ7	NCBITaxon:9606	Homo sapiens	15	R-HSA-389826	glyoxylate + NADPH + H+ => glycolate + NADP+	yes	reactome/R-HSA-389826.md	glyoxylate + NADPH + H+ => glycolate + NADP+	Homo sapiens	GO:0030267	glyoxylate reductase (NADPH) activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation of glyoxylate reductase (NADPH) activity for the reaction glyoxylate + NADPH + H+ => glycolate + NADP+, the enzyme's core catalytic step.
human	GRHPR	genes/human/GRHPR/GRHPR-ai-review.yaml	GRHPR	Q9UBQ7	NCBITaxon:9606	Homo sapiens	27	R-HSA-389826	glyoxylate + NADPH + H+ => glycolate + NADP+	yes	reactome/R-HSA-389826.md	glyoxylate + NADPH + H+ => glycolate + NADP+	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS annotation placing GRHPR in the peroxisomal matrix (Reactome describes a ""Peroxisomal GRHPR""). The enzyme is predominantly cytosolic; a minor peroxisomal pool has been proposed but the 328-residue sequence carries no PTS1/PTS2 targeting signal."
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	47	R-HSA-9716258	Dimethyl fumarate modifies Cys191 in GSDMD	yes	reactome/R-HSA-9716258.md	Dimethyl fumarate modifies Cys191 in GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	48	R-HSA-9693324	Disulfiram covalently modifies Cys191 in GSDMD	yes	reactome/R-HSA-9693324.md	Disulfiram covalently modifies Cys191 in GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	49	R-HSA-9710106	ELANE cleaves GSDMD	yes	reactome/R-HSA-9710106.md	ELANE cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	50	R-HSA-9686088	CASP3 cleaves GSDMD	yes	reactome/R-HSA-9686088.md	CASP3 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	51	R-HSA-9647619	GSDMD forms ring‐shaped oligomers	yes	reactome/R-HSA-9647619.md	GSDMD forms ring‐shaped oligomers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	52	R-HSA-9647631	GSDMD (1-275) binds PIPs	yes	reactome/R-HSA-9647631.md	GSDMD (1-275) binds PIPs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	53	R-HSA-9647643	GSDMD (1-275) binds bacterial cardiolipin	yes	reactome/R-HSA-9647643.md	GSDMD (1-275) binds bacterial cardiolipin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	54	R-HSA-9647645	GSDMD oligomerizes into arc-, slit-shaped structures	yes	reactome/R-HSA-9647645.md	GSDMD oligomerizes into arc-, slit-shaped structures	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	55	R-HSA-9647680	CASP1 cleaves GSDMD	yes	reactome/R-HSA-9647680.md	CASP1 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	56	R-HSA-9710353	GSDMD (1-275) binds cardiolipin	yes	reactome/R-HSA-9710353.md	GSDMD (1-275) binds cardiolipin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	57	R-HSA-9947997	CASP5 cleaves GSDMD	yes	reactome/R-HSA-9947997.md	CASP5 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	58	R-HSA-9948146	CASP4 cleaves GSDMD	yes	reactome/R-HSA-9948146.md	CASP4 cleaves GSDMD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from a Reactome reaction (GSDMD cleavage/oligomerization/lipid-binding step); correct location of the GSDMD precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	68	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS extracellular region from a neutrophil tertiary-granule exocytosis pathway; the route asserted is granule-proteomic, but the extracellular location itself is independently supported.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	69	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS extracellular region from a neutrophil specific-granule exocytosis pathway; the route asserted is granule-proteomic, but the extracellular location itself is independently supported.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	70	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS extracellular region from a neutrophil ficolin-1-rich-granule exocytosis pathway; the route asserted is granule-proteomic, but the extracellular location itself is independently supported.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	71	R-HSA-9710294	GSDMD expression mediated by IRF2, IRF1	yes	reactome/R-HSA-9710294.md	GSDMD expression mediated by IRF2, IRF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol localization from the Reactome GSDMD-expression reaction; correct location of the precursor.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	72	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	TAS specific granule lumen localization from neutrophil granule proteomics; bulk-proteomic assignment that places a cytosolic protein inside a granule lumen.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	73	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	TAS tertiary granule lumen localization from neutrophil granule proteomics; bulk-proteomic assignment that places a cytosolic protein inside a granule lumen.
human	GSDMD	genes/human/GSDMD/GSDMD-ai-review.yaml	GSDMD	P57764	NCBITaxon:9606	Homo sapiens	74	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	TAS ficolin-1-rich granule lumen localization from neutrophil granule proteomics; bulk-proteomic assignment that places a cytosolic protein inside a granule lumen.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	140	R-HSA-4641262	Disassembly of the destruction complex and recruitment of AXIN to the membrane	yes	reactome/R-HSA-4641262.md	Disassembly of the destruction complex and recruitment of AXIN to the membrane	Homo sapiens	GO:0060070	canonical Wnt signaling pathway	TAS	involved_in	BP	false		ACCEPT	canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	141	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	regulation of cellular response to heat is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	142	R-HSA-195283	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	yes	reactome/R-HSA-195283.md	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	143	R-HSA-195287	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	yes	reactome/R-HSA-195287.md	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	144	R-HSA-195300	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	yes	reactome/R-HSA-195300.md	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	145	R-HSA-201677	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	yes	reactome/R-HSA-201677.md	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	146	R-HSA-3371435	Constitutive phosphorylation by GSK3	yes	reactome/R-HSA-3371435.md	Constitutive phosphorylation by GSK3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	147	R-HSA-399951	Phosphorylation of CRMPs by GSK3beta	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	148	R-HSA-5610732	GSK3 phosphorylates p-GLI3	yes	reactome/R-HSA-5610732.md	GSK3 phosphorylates p-GLI3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	149	R-HSA-9683664	GSK3 phosphorylates Nucleoprotein	yes	reactome/R-HSA-9683664.md	GSK3 phosphorylates Nucleoprotein	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	150	R-HSA-9729260	GSK3 phosphorylates nucleoprotein	yes	reactome/R-HSA-9729260.md	GSK3 phosphorylates nucleoprotein	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	151	R-HSA-9762094	GSK3B phosphorylates p-NFE2L2	yes	reactome/R-HSA-9762094.md	GSK3B phosphorylates p-NFE2L2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	152	R-HSA-9824995	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405	yes	reactome/R-HSA-9824995.md	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	153	R-HSA-9824999	GSK3B phosphorylates p-S73 MITF-M at residue S69	yes	reactome/R-HSA-9824999.md	GSK3B phosphorylates p-S73 MITF-M at residue S69	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	154	R-HSA-9929360	GSK3B phosphorylates CD274	yes	reactome/R-HSA-9929360.md	GSK3B phosphorylates CD274	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	155	R-HSA-9943675	GSK3B phosphorylates CDC25A	yes	reactome/R-HSA-9943675.md	GSK3B phosphorylates CDC25A	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	156	R-NUL-209146	Murine Axin1 is further phosphorylated by Human GSK3beta	yes	reactome/R-NUL-209146.md	Murine Axin1 is further phosphorylated by Human GSK3beta	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	157	R-NUL-9008636	GSK3B phosphorylates Runx2	yes	reactome/R-NUL-9008636.md	GSK3B phosphorylates Runx2	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	183	R-HSA-9683610	Maturation of nucleoprotein	yes	reactome/R-HSA-9683610.md	Maturation of nucleoprotein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	188	R-HSA-9929360	GSK3B phosphorylates CD274	yes	reactome/R-HSA-9929360.md	GSK3B phosphorylates CD274	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	212	R-HSA-9694631	Maturation of nucleoprotein	yes	reactome/R-HSA-9694631.md	Maturation of nucleoprotein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	285	R-HSA-9762094	GSK3B phosphorylates p-NFE2L2	yes	reactome/R-HSA-9762094.md	GSK3B phosphorylates p-NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	286	R-HSA-9824995	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405	yes	reactome/R-HSA-9824995.md	GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	287	R-HSA-9824999	GSK3B phosphorylates p-S73 MITF-M at residue S69	yes	reactome/R-HSA-9824999.md	GSK3B phosphorylates p-S73 MITF-M at residue S69	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	288	R-HSA-9943675	GSK3B phosphorylates CDC25A	yes	reactome/R-HSA-9943675.md	GSK3B phosphorylates CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	289	R-NUL-9008555	Runx2 binds GSK3B	yes	reactome/R-NUL-9008555.md	Runx2 binds GSK3B	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	290	R-NUL-9008636	GSK3B phosphorylates Runx2	yes	reactome/R-NUL-9008636.md	GSK3B phosphorylates Runx2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	296	R-HSA-5339713	Misspliced GSK3beta mutants stabilize beta-catenin levels	yes	reactome/R-HSA-5339713.md	Misspliced GSK3beta mutants stabilize beta-catenin levels	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	300	R-HSA-2399966	AKT1 E17K mutant phosphorylates GSK3	yes	reactome/R-HSA-2399966.md	AKT1 E17K mutant phosphorylates GSK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	301	R-HSA-1504186	DVL recruits GSK3beta:AXIN1 to the receptor complex	yes	reactome/R-HSA-1504186.md	DVL recruits GSK3beta:AXIN1 to the receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	302	R-HSA-195251	Assembly of the destruction complex	yes	reactome/R-HSA-195251.md	Assembly of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	303	R-HSA-195275	Phosphorylation of APC component of the destruction complex	yes	reactome/R-HSA-195275.md	Phosphorylation of APC component of the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	304	R-HSA-195280	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	yes	reactome/R-HSA-195280.md	Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	305	R-HSA-195283	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	yes	reactome/R-HSA-195283.md	Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	306	R-HSA-195287	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	yes	reactome/R-HSA-195287.md	Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	307	R-HSA-195300	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	yes	reactome/R-HSA-195300.md	Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	308	R-HSA-195304	Association of beta-catenin with the destruction complex	yes	reactome/R-HSA-195304.md	Association of beta-catenin with the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	309	R-HSA-195318	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	yes	reactome/R-HSA-195318.md	Phosphorylation of beta-catenin at Ser45 by CK1 alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	310	R-HSA-201677	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	yes	reactome/R-HSA-201677.md	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	311	R-HSA-201685	Beta-catenin is released from the destruction complex	yes	reactome/R-HSA-201685.md	Beta-catenin is released from the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	312	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	313	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	314	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	315	R-HSA-3371435	Constitutive phosphorylation by GSK3	yes	reactome/R-HSA-3371435.md	Constitutive phosphorylation by GSK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	316	R-HSA-399951	Phosphorylation of CRMPs by GSK3beta	yes	reactome/R-HSA-399951.md	Phosphorylation of CRMPs by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	317	R-HSA-4791278	APC truncation mutants have impaired AXIN binding	yes	reactome/R-HSA-4791278.md	APC truncation mutants have impaired AXIN binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	318	R-HSA-4827388	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	yes	reactome/R-HSA-4827388.md	CTNNB1 S45 mutants aren't phosphorylated by CK1alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	319	R-HSA-4839634	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839634.md	CTNNB1 S33 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	320	R-HSA-4839635	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839635.md	CTNNB1 S37 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	321	R-HSA-4839638	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	yes	reactome/R-HSA-4839638.md	CTNNB1 T41 mutants aren't phosphorylated by GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	322	R-HSA-4839734	AXIN mutants destabilize the destruction complex	yes	reactome/R-HSA-4839734.md	AXIN mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	323	R-HSA-4839746	Truncated AMER1 mutants destabilize the destruction complex	yes	reactome/R-HSA-4839746.md	Truncated AMER1 mutants destabilize the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	324	R-HSA-5229343	AXIN is phosphorylated in the destruction complex	yes	reactome/R-HSA-5229343.md	AXIN is phosphorylated in the destruction complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	325	R-HSA-5323526	FRAT proteins bind GSK3beta	yes	reactome/R-HSA-5323526.md	FRAT proteins bind GSK3beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	326	R-HSA-5368596	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	yes	reactome/R-HSA-5368596.md	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	327	R-HSA-5610732	GSK3 phosphorylates p-GLI3	yes	reactome/R-HSA-5610732.md	GSK3 phosphorylates p-GLI3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	328	R-HSA-9683664	GSK3 phosphorylates Nucleoprotein	yes	reactome/R-HSA-9683664.md	GSK3 phosphorylates Nucleoprotein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	329	R-HSA-9687724	GSK3B binds GSKi	yes	reactome/R-HSA-9687724.md	GSK3B binds GSKi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	330	R-HSA-9729260	GSK3 phosphorylates nucleoprotein	yes	reactome/R-HSA-9729260.md	GSK3 phosphorylates nucleoprotein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	331	R-NUL-1458902	frog CK1gamma phosphorylates LRP5/6	yes	reactome/R-NUL-1458902.md	frog CK1gamma phosphorylates LRP5/6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSK3B	genes/human/GSK3B/GSK3B-ai-review.yaml	GSK3B	P49841	NCBITaxon:9606	Homo sapiens	332	R-NUL-209146	Murine Axin1 is further phosphorylated by Human GSK3beta	yes	reactome/R-NUL-209146.md	Murine Axin1 is further phosphorylated by Human GSK3beta	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur.
human	GSR	genes/human/GSR/GSR-ai-review.yaml	GSR	P00390	NCBITaxon:9606	Homo sapiens	21	R-HSA-71682	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+	yes	reactome/R-HSA-71682.md	glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the cytosolic GR-catalyzed reaction in the cytosol. Consistent with the cytoplasmic isoform and HPA IDA. Core site.
human	GSR	genes/human/GSR/GSR-ai-review.yaml	GSR	P00390	NCBITaxon:9606	Homo sapiens	22	R-HSA-9761843	NFE2L2-dependent GSR gene expression	yes	reactome/R-HSA-9761843.md	NFE2L2-dependent GSR gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation associated with the NFE2L2-dependent GSR expression pathway, again localizing GR to the cytosol. Redundant with the other cytosol annotations but correct.
human	GSR	genes/human/GSR/GSR-ai-review.yaml	GSR	P00390	NCBITaxon:9606	Homo sapiens	25	R-HSA-3323079	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+	yes	reactome/R-HSA-3323079.md	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation localizing the GR-catalyzed GSSG reduction to the mitochondrial matrix, consistent with the mitochondrial isoform. A specific, correct site of action.
human	GSS	genes/human/GSS/GSS-ai-review.yaml	GSS	P48637	NCBITaxon:9606	Homo sapiens	17	R-HSA-5602901	Defective GSS does not synthesize GSH	yes	reactome/R-HSA-5602901.md	Defective GSS does not synthesize GSH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization from Reactome pathway annotation for the defective GSS pathway.
human	GSS	genes/human/GSS/GSS-ai-review.yaml	GSS	P48637	NCBITaxon:9606	Homo sapiens	19	R-HSA-174394	GSS:Mg2+ dimer synthesizes GSH	yes	reactome/R-HSA-174394.md	GSS:Mg2+ dimer synthesizes GSH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol localization from Reactome pathway annotation for GSH synthesis.
human	GSTZ1	genes/human/GSTZ1/GSTZ1-ai-review.yaml	GSTZ1	O43708	NCBITaxon:9606	Homo sapiens	22	R-HSA-9011595	GSTZ1 dimer dehalogenates DCA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of GSTZ1 in the mitochondrial matrix, associated with the DCA dehalogenation reaction. Matches submitochondrial fractionation data.
human	GSTZ1	genes/human/GSTZ1/GSTZ1-ai-review.yaml	GSTZ1	O43708	NCBITaxon:9606	Homo sapiens	23	R-HSA-176054	GST dimers conjugate GSH with cytosolic substrates	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation of cytosolic localisation associated with GST-mediated glutathione conjugation. Consistent with the canonical compartment of GSTZ1.
human	GSTZ1	genes/human/GSTZ1/GSTZ1-ai-review.yaml	GSTZ1	O43708	NCBITaxon:9606	Homo sapiens	24	R-HSA-71173	GSTZ1 isomerizes 4-MAA	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation of cytosolic localisation associated with the 4-MAA isomerisation reaction (GSTZ1 isomerizes 4-MAA), consistent with the enzyme's canonical cytosolic MAAI activity.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	32	R-HSA-109638	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex	yes	reactome/R-HSA-109638.md	Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	33	R-HSA-109639	Formation of the closed pre-initiation complex	yes	reactome/R-HSA-109639.md	Formation of the closed pre-initiation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	34	R-HSA-111264	Addition of nucleotides between position +11 and +30	yes	reactome/R-HSA-111264.md	Addition of nucleotides between position +11 and +30	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	35	R-HSA-112379	Recruitment of elongation factors to form elongation complex	yes	reactome/R-HSA-112379.md	Recruitment of elongation factors to form elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	36	R-HSA-112381	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex	yes	reactome/R-HSA-112381.md	Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	37	R-HSA-112383	Hypophosphorylation of RNA Pol II CTD by FCP1P protein	yes	reactome/R-HSA-112383.md	Hypophosphorylation of RNA Pol II CTD by FCP1P protein	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	38	R-HSA-112385	Addition of nucleotides leads to transcript elongation	yes	reactome/R-HSA-112385.md	Addition of nucleotides leads to transcript elongation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	39	R-HSA-112392	Resumption of elongation after recovery from pausing	yes	reactome/R-HSA-112392.md	Resumption of elongation after recovery from pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	40	R-HSA-112395	Abortive termination of elongation after arrest	yes	reactome/R-HSA-112395.md	Abortive termination of elongation after arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	41	R-HSA-112396	Separation of elongating transcript from template	yes	reactome/R-HSA-112396.md	Separation of elongating transcript from template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	42	R-HSA-113402	Formation of DSIF:NELF:early elongation complex	yes	reactome/R-HSA-113402.md	Formation of DSIF:NELF:early elongation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	43	R-HSA-113407	DSIF complex binds to RNA Pol II (hypophosphorylated)	yes	reactome/R-HSA-113407.md	DSIF complex binds to RNA Pol II (hypophosphorylated)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	44	R-HSA-113409	Abortive termination of early transcription elongation by DSIF:NELF	yes	reactome/R-HSA-113409.md	Abortive termination of early transcription elongation by DSIF:NELF	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	45	R-HSA-113411	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	yes	reactome/R-HSA-113411.md	2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	46	R-HSA-113412	Pol II elongation complex moves on the template as transcript elongates	yes	reactome/R-HSA-113412.md	Pol II elongation complex moves on the template as transcript elongates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	47	R-HSA-113413	TFIIS-mediated recovery of elongation from arrest	yes	reactome/R-HSA-113413.md	TFIIS-mediated recovery of elongation from arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	48	R-HSA-113414	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	yes	reactome/R-HSA-113414.md	7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	49	R-HSA-113429	Elongating transcript encounters a lesion in the template	yes	reactome/R-HSA-113429.md	Elongating transcript encounters a lesion in the template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	50	R-HSA-113430	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex	yes	reactome/R-HSA-113430.md	Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	51	R-HSA-170704	Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex	yes	reactome/R-HSA-170704.md	Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	52	R-HSA-170706	Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex	yes	reactome/R-HSA-170706.md	Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	53	R-HSA-6797606	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	yes	reactome/R-HSA-6797606.md	CDK12 phosphorylates RNA Pol II CTD at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	54	R-HSA-6797616	CCNK:CDK12 binds RNA Pol II at DNA repair genes	yes	reactome/R-HSA-6797616.md	CCNK:CDK12 binds RNA Pol II at DNA repair genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	55	R-HSA-6803523	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA	yes	reactome/R-HSA-6803523.md	PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	56	R-HSA-6803527	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	yes	reactome/R-HSA-6803527.md	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	57	R-HSA-6803836	FGFR2b-specific alternative splicing produces FGFR2b transcript	yes	reactome/R-HSA-6803836.md	FGFR2b-specific alternative splicing produces FGFR2b transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	58	R-HSA-6803838	FGFR2c-specific alternative splicing produces FGFR2c transcript	yes	reactome/R-HSA-6803838.md	FGFR2c-specific alternative splicing produces FGFR2c transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	59	R-HSA-6810233	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	yes	reactome/R-HSA-6810233.md	CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	60	R-HSA-6810234	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene	yes	reactome/R-HSA-6810234.md	General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	61	R-HSA-6810235	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain	yes	reactome/R-HSA-6810235.md	RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	62	R-HSA-6810238	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)	yes	reactome/R-HSA-6810238.md	RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	63	R-HSA-6814549	Pre-snRNA transcript initiation, Integrator binding, LEC binding	yes	reactome/R-HSA-6814549.md	Pre-snRNA transcript initiation, Integrator binding, LEC binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	64	R-HSA-6814555	Integrator complex processes the 3' end of snRNA	yes	reactome/R-HSA-6814555.md	Integrator complex processes the 3' end of snRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	65	R-HSA-6814559	Pre-snRNA is elongated and capped with 7-methylguanosine	yes	reactome/R-HSA-6814559.md	Pre-snRNA is elongated and capped with 7-methylguanosine	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	66	R-HSA-6814885	CBCAP complex binds 7-methylguanosine cap of snRNA	yes	reactome/R-HSA-6814885.md	CBCAP complex binds 7-methylguanosine cap of snRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	67	R-HSA-72095	Internal Methylation of mRNA	yes	reactome/R-HSA-72095.md	Internal Methylation of mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	68	R-HSA-72103	Formation of pre-mRNPs	yes	reactome/R-HSA-72103.md	Formation of pre-mRNPs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	69	R-HSA-73946	Abortive initiation after formation of the first phosphodiester bond	yes	reactome/R-HSA-73946.md	Abortive initiation after formation of the first phosphodiester bond	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	70	R-HSA-75079	Formation of AT-AC C complex	yes	reactome/R-HSA-75079.md	Formation of AT-AC C complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	71	R-HSA-75080	Formation of AT-AC A complex	yes	reactome/R-HSA-75080.md	Formation of AT-AC A complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	72	R-HSA-75081	Formation of AT-AC B Complex	yes	reactome/R-HSA-75081.md	Formation of AT-AC B Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	73	R-HSA-75082	ATAC spliceosome mediated Lariat formation,5' splice site cleavage	yes	reactome/R-HSA-75082.md	ATAC spliceosome mediated Lariat formation,5' splice site cleavage	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	74	R-HSA-75083	ATAC spliceosome mediated 3' splice site cleavage, exon ligation	yes	reactome/R-HSA-75083.md	ATAC spliceosome mediated 3' splice site cleavage, exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	75	R-HSA-75095	Binding of TFIIE to the growing preinitiation complex	yes	reactome/R-HSA-75095.md	Binding of TFIIE to the growing preinitiation complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	76	R-HSA-75850	Addition of the third nucleotide on the nascent transcript	yes	reactome/R-HSA-75850.md	Addition of the third nucleotide on the nascent transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	77	R-HSA-75856	Abortive Initiation Before Second Transition	yes	reactome/R-HSA-75856.md	Abortive Initiation Before Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	78	R-HSA-75861	NTP Binds Active Site of RNA Polymerase II	yes	reactome/R-HSA-75861.md	NTP Binds Active Site of RNA Polymerase II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	79	R-HSA-75862	Fall Back to Closed Pre-initiation Complex	yes	reactome/R-HSA-75862.md	Fall Back to Closed Pre-initiation Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	80	R-HSA-75864	Newly Formed Phosphodiester Bond Stabilized and PPi Released	yes	reactome/R-HSA-75864.md	Newly Formed Phosphodiester Bond Stabilized and PPi Released	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	81	R-HSA-75866	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP	yes	reactome/R-HSA-75866.md	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	82	R-HSA-75869	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	yes	reactome/R-HSA-75869.md	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	83	R-HSA-75873	Addition of Nucleotides 5 through 9 on the growing Transcript	yes	reactome/R-HSA-75873.md	Addition of Nucleotides 5 through 9 on the growing Transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	84	R-HSA-75891	Abortive Initiation After Second Transition	yes	reactome/R-HSA-75891.md	Abortive Initiation After Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	85	R-HSA-75949	RNA Polymerase II Promoter Opening: First Transition	yes	reactome/R-HSA-75949.md	RNA Polymerase II Promoter Opening: First Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	86	R-HSA-76576	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition	yes	reactome/R-HSA-76576.md	Addition of nucleotides 10 and 11 on the growing transcript: Third Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	87	R-HSA-77068	Activation of GT	yes	reactome/R-HSA-77068.md	Activation of GT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	88	R-HSA-77069	RNA Polymerase II CTD (phosphorylated) binds to CE	yes	reactome/R-HSA-77069.md	RNA Polymerase II CTD (phosphorylated) binds to CE	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	89	R-HSA-77071	Phosphorylation (Ser5) of RNA pol II CTD	yes	reactome/R-HSA-77071.md	Phosphorylation (Ser5) of RNA pol II CTD	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	90	R-HSA-77073	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)	yes	reactome/R-HSA-77073.md	SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	91	R-HSA-77077	Capping complex formation	yes	reactome/R-HSA-77077.md	Capping complex formation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	92	R-HSA-77078	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme	yes	reactome/R-HSA-77078.md	Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	93	R-HSA-77081	Formation of the CE:GMP intermediate complex	yes	reactome/R-HSA-77081.md	Formation of the CE:GMP intermediate complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	94	R-HSA-77083	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA	yes	reactome/R-HSA-77083.md	Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	95	R-HSA-77085	Dissociation of transcript with 5'-GMP from GT	yes	reactome/R-HSA-77085.md	Dissociation of transcript with 5'-GMP from GT	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	96	R-HSA-77090	Methylation of GMP-cap by RNA Methyltransferase	yes	reactome/R-HSA-77090.md	Methylation of GMP-cap by RNA Methyltransferase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	97	R-HSA-77095	Recognition and binding of the mRNA cap by the cap-binding complex	yes	reactome/R-HSA-77095.md	Recognition and binding of the mRNA cap by the cap-binding complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	98	R-HSA-9012315	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene	yes	reactome/R-HSA-9012315.md	ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	99	R-HSA-9012319	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD	yes	reactome/R-HSA-9012319.md	p-TEFb phosphorylates serine 2 in RNA polymerase II CTD	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	100	R-HSA-9613494	Unwinding of DNA for the Nascent Transcript: Second Transition	yes	reactome/R-HSA-9613494.md	Unwinding of DNA for the Nascent Transcript: Second Transition	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	101	R-HSA-9613497	Unwinding DNA for the nascent transcript	yes	reactome/R-HSA-9613497.md	Unwinding DNA for the nascent transcript	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	102	R-HSA-9770119	Formation of the Spliceosomal E complex	yes	reactome/R-HSA-9770119.md	Formation of the Spliceosomal E complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	103	R-HSA-9770129	Formation of the Spliceosomal A complex	yes	reactome/R-HSA-9770129.md	Formation of the Spliceosomal A complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	104	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	105	R-HSA-9770132	Formation of the Spliceosomal Pre-B complex	yes	reactome/R-HSA-9770132.md	Formation of the Spliceosomal Pre-B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	106	R-HSA-9770141	Formation of the Spliceosomal C* complex	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	107	R-HSA-9770142	Formation of the Spliceosomal B complex	yes	reactome/R-HSA-9770142.md	Formation of the Spliceosomal B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	108	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	109	R-HSA-9770236	Formation of the Spliceosomal P complex and exon ligation	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	110	R-HSA-9770847	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTF2F2	genes/human/GTF2F2/GTF2F2-ai-review.yaml	GTF2F2	P13984	NCBITaxon:9606	Homo sapiens	111	R-HSA-9794542	Formation of the Spliceosomal C complex containing intron lariat	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	GTF2F2 is placed in the nucleoplasm as a participant in Reactome reactions covering Pol II preinitiation, initiation, promoter escape, elongation, capping, splicing and related steps. The localization is correct; the many reaction-specific references reflect Reactome pathway granularity rather than distinct localizations.
human	GTPBP2	genes/human/GTPBP2/GTPBP2-ai-review.yaml	GTPBP2	Q9BX10	NCBITaxon:9606	Homo sapiens	11	R-HSA-481007	Exocytosis of platelet alpha granule content	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome platelet-degranulation localization, reflecting detection of GTPBP2 in platelet alpha-granule releasate; not its functional compartment.
human	GTPBP2	genes/human/GTPBP2/GTPBP2-ai-review.yaml	GTPBP2	Q9BX10	NCBITaxon:9606	Homo sapiens	12	R-HSA-481007	Exocytosis of platelet alpha granule content	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome platelet alpha-granule lumen localization from platelet proteomics; a specialized context distinct from GTPBP2's core function.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	13	R-HSA-2318373	Defective GUSB does not hydrolyse (HA)2	yes	reactome/R-HSA-2318373.md	Defective GUSB does not hydrolyse (HA)2	Homo sapiens	GO:0004566	beta-glucuronidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of beta-glucuronidase activity in the context of hyaluronan/GAG degradation reactions. Consistent with the core molecular function.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	14	R-HSA-9036068	Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc	yes	reactome/R-HSA-9036068.md	Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc	Homo sapiens	GO:0004566	beta-glucuronidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of beta-glucuronidase activity (GlcA-beta1,3-GlcNAc hydrolysis reaction). Consistent with the core molecular function.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	15	R-HSA-9036070	Defective GUSB does not hydrolyse CS/HS precursor	yes	reactome/R-HSA-9036070.md	Defective GUSB does not hydrolyse CS/HS precursor	Homo sapiens	GO:0004566	beta-glucuronidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of beta-glucuronidase activity (CS/HS precursor hydrolysis). Consistent with the core molecular function.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation of extracellular localisation via neutrophil azurophil granule exocytosis (degranulation). Real but peripheral to the core lysosomal role.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	19	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation of extracellular localisation via ficolin-1-rich granule exocytosis. Peripheral to the core lysosomal role.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) localisation to the azurophil granule lumen of neutrophils, consistent with GUSB being stored in these lysosome-related granules and released on degranulation.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	21	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) localisation to the ficolin-1-rich granule lumen of neutrophils. Cell-type-specific storage location, peripheral to the core lysosomal role.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	28	R-HSA-2318373	Defective GUSB does not hydrolyse (HA)2	yes	reactome/R-HSA-2318373.md	Defective GUSB does not hydrolyse (HA)2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen, the core compartment where GUSB acts as a soluble exoglycosidase in GAG degradation.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	29	R-HSA-9036068	Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc	yes	reactome/R-HSA-9036068.md	Defective GUSB does not hydrolyse GlcA-β1,3-GlcNAc	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen (CS/HS degradation context). Core compartment of action.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	30	R-HSA-9036070	Defective GUSB does not hydrolyse CS/HS precursor	yes	reactome/R-HSA-9036070.md	Defective GUSB does not hydrolyse CS/HS precursor	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen (CS/HS degradation context). Core compartment of action.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	31	R-HSA-1678854	GUSB tetramer hydrolyses CS/HS precursor	yes	reactome/R-HSA-1678854.md	GUSB tetramer hydrolyses CS/HS precursor	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen (GUSB tetramer hydrolyses CS/HS precursor). Core compartment of action.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	32	R-HSA-2162226	GUSB tetramer hydrolyzes GlcA-β1,3-GlcNAc	yes	reactome/R-HSA-2162226.md	GUSB tetramer hydrolyzes GlcA-β1,3-GlcNAc	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen (GUSB tetramer hydrolyzes GlcA-beta1,3-GlcNAc). Core compartment of action.
human	GUSB	genes/human/GUSB/GUSB-ai-review.yaml	GUSB	P08236	NCBITaxon:9606	Homo sapiens	33	R-HSA-2162227	GUSB tetramer hydrolyses (HA)2	yes	reactome/R-HSA-2162227.md	GUSB tetramer hydrolyses (HA)2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation to the lysosomal lumen (GUSB tetramer hydrolyses (HA)2). Core compartment of action.
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	13	R-HSA-3322077	Glycogen synthesis	yes	reactome/R-HSA-3322077.md	Glycogen synthesis	Homo sapiens	GO:0005978	glycogen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome traceable-author-statement annotation to glycogen biosynthetic process via the ""Glycogen synthesis"" pathway."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	27	R-HSA-9036727	GAA hydrolyzes lysosomal glycogen	yes	reactome/R-HSA-9036727.md	GAA hydrolyzes lysosomal glycogen	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS annotation placing GYG1 in the lysosomal lumen, arising from its appearance in the ""GAA hydrolyzes lysosomal glycogen"" reaction (Pompe disease / lysosomal glycogen degradation pathway) where glycogen (with its glycogenin core) is transported to the lysosome."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	28	R-HSA-9036729	Defective GAA does not hydrolyze lysosomal glycogen	no				GO:0043202	lysosomal lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS annotation to lysosomal lumen from the ""Defective GAA does not hydrolyze lysosomal glycogen"" reaction (Pompe disease). Same pathway-context artifact as the R-HSA-9036727 annotation."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS annotation to extracellular region from the ""Exocytosis of secretory granule lumen proteins"" reaction (neutrophil degranulation pathway), in which GYG1 was detected in neutrophil granule proteomes."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	30	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS annotation to extracellular region from the ""Exocytosis of ficolin-rich granule lumen proteins"" reaction (neutrophil degranulation pathway)."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	31	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to secretory granule lumen from the neutrophil degranulation pathway, based on detection of GYG1 in secretory granule proteomes.
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	32	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to ficolin-1-rich granule lumen from the neutrophil degranulation pathway.
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	34	R-HSA-3322001	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	yes	reactome/R-HSA-3322001.md	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1"" reaction of glycogen synthesis. Correctly localizes GYG1 to the cytosol."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	35	R-HSA-3322005	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	yes	reactome/R-HSA-3322005.md	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	36	R-HSA-3322041	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	37	R-HSA-3322057	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	38	R-HSA-71552	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin	yes	reactome/R-HSA-71552.md	limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol from a glycogenin/glycogen limit-dextrin reaction. Correct cytosolic localization.
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	39	R-HSA-71593	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose	yes	reactome/R-HSA-71593.md	((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to cytosol from a glycogenin poly-glucosyl reaction. Correct cytosolic localization.
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	40	R-HSA-3322003	Autoglucosylation of GYG1 complexed with GYS1-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Autoglucosylation of GYG1 complexed with GYS1-b"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	41	R-HSA-3322025	Autoglucosylation of GYG1 complexed with GYS1-a	yes	reactome/R-HSA-3322025.md	Autoglucosylation of GYG1 complexed with GYS1-a	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Autoglucosylation of GYG1 complexed with GYS1-a"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	42	R-HSA-3781001	EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex"" reaction (Lafora disease pathway). Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	43	R-HSA-3781009	NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1"" reaction (Lafora disease pathway). Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	44	R-HSA-3781018	EPM2A dimer dephosphorylates phosphoglycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""EPM2A dimer dephosphorylates phosphoglycogen-GYG1"" reaction (Lafora disease pathway). Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	45	R-HSA-3781023	PPP1R3C binds to glycogen:GYG1:GYS1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""PPP1R3C binds to glycogen:GYG1:GYS1"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	46	R-HSA-3781024	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	47	R-HSA-3791349	Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	48	R-HSA-3797226	Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)"" reaction. Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	49	R-HSA-3814838	Defective GYG1 is not autoglucosyolated	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Defective GYG1 is not autoglucosyolated"" reaction (glycogen storage disease type XV pathway). Correct cytosolic localization."
human	GYG1	genes/human/GYG1/GYG1-ai-review.yaml	GYG1	P46976	NCBITaxon:9606	Homo sapiens	50	R-HSA-3828061	Defective GYS1 does not transfer glucose to growing glycogen chains	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol from the ""Defective GYS1 does not transfer glucose to growing glycogen chains"" reaction. Correct cytosolic localization."
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	23	R-HSA-3322077	Glycogen synthesis	yes	reactome/R-HSA-3322077.md	Glycogen synthesis	Homo sapiens	GO:0005978	glycogen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (Glycogen synthesis) traceable assignment of glycogen biosynthetic process; consistent with the core role of GYS1.
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	26	R-HSA-3828061	Defective GYS1 does not transfer glucose to growing glycogen chains	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome traceable localization to cytosol (from the ""Defective GYS1"" GSD 0 reaction context); consistent with GYS1 being a soluble cytosolic enzyme."
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	29	R-HSA-3322001	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	yes	reactome/R-HSA-3322001.md	GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (GYS1 polyglucosylation of oligoGlc-GYG1).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	30	R-HSA-3322005	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	yes	reactome/R-HSA-3322005.md	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (branch-formation reaction context with GYS1-a).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	31	R-HSA-3322025	Autoglucosylation of GYG1 complexed with GYS1-a	yes	reactome/R-HSA-3322025.md	Autoglucosylation of GYG1 complexed with GYS1-a	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (autoglucosylation of GYG1 complexed with GYS1-a).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	32	R-HSA-3781001	EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG1 complex	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (EPM2A/laforin binding to PPP1R3C:phosphoglycogen-GYG1 complex context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	33	R-HSA-3781009	NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (NHLRC1-mediated ubiquitination context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	34	R-HSA-3781018	EPM2A dimer dephosphorylates phosphoglycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (EPM2A dephosphorylation of phosphoglycogen-GYG1 context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	35	R-HSA-3781023	PPP1R3C binds to glycogen:GYG1:GYS1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (PPP1R3C binding to glycogen:GYG1:GYS1 context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	36	R-HSA-3781024	GYS1 catalyzes the incorporation of phosphoglucose into glycogen-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (GYS1 incorporation of phosphoglucose into glycogen-GYG1 context; the phosphate-side-reaction).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	37	R-HSA-3791349	Defective EPM2A does not dephosphorylate phosphoglycogen (type 2A disease)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (defective EPM2A / Lafora disease context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	38	R-HSA-3797226	Defective NHLRC1 does not ubiquitinate EPM2A (laforin) and PPP1R3C (PTG) (type 2B disease)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (defective NHLRC1 / Lafora disease context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	39	R-HSA-3814838	Defective GYG1 is not autoglucosyolated	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (defective GYG1 autoglucosylation context).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	42	R-HSA-3322003	Autoglucosylation of GYG1 complexed with GYS1-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (autoglucosylation of GYG1 complexed with GYS1-b).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	43	R-HSA-3322041	Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (phosphorylated GYS1 polyglucosylation of oligoGlc-GYG1).
human	GYS1	genes/human/GYS1/GYS1-ai-review.yaml	GYS1	P13807	NCBITaxon:9606	Homo sapiens	44	R-HSA-3322057	GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to cytosol (branch formation in polyGlc-GYG1 complexed with GYS1-b).
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	8	R-HSA-3322077	Glycogen synthesis	yes	reactome/R-HSA-3322077.md	Glycogen synthesis	Homo sapiens	GO:0005978	glycogen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assignment placing GYS2 in the glycogen synthesis pathway, where it catalyzes the linear alpha-1,4 extension of the glucose oligomer.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	12	R-HSA-3780994	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2	no				GO:0061547	glycogen synthase activity, transferring glucose-1-phosphate	TAS	enables	MF	false		ACCEPT	Reactome-curated minor activity in which GYS2 incorporates phosphoglucose into glycogen, the origin of glycogen phosphomonoesters.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	13	R-HSA-3858506	Defective GYS2 does not transfer glucose to growing glycogen chains	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	14	R-HSA-3322019	Autoglucosylation of GYG2 complexed with GYS2-b	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	15	R-HSA-3322009	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2	yes	reactome/R-HSA-3322009.md	GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	16	R-HSA-3322014	Autoglucosylation of GYG2 complexed with GYS2-a	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	17	R-HSA-3322016	GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	18	R-HSA-3780994	GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	19	R-HSA-3780995	NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	20	R-HSA-3780997	PPP1R3C binds to glycogen:GYG2:GYS2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	21	R-HSA-3781011	EPM2A dimer dephosphorylates phosphoglycogen-GYG2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	22	R-HSA-3781021	EPM2A dimer binds PPP1R3C:phosphoglycogen-GYG2 complex	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	GYS2	genes/human/GYS2/GYS2-ai-review.yaml	GYS2	P54840	NCBITaxon:9606	Homo sapiens	23	R-HSA-3878762	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	yes	reactome/R-HSA-3878762.md	Defective GBE1 does not catalyze branch formation in growing glycogen chains (liver)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of cytosolic localization for GYS2.
human	HAAO	genes/human/HAAO/HAAO-ai-review.yaml	HAAO	P46952	NCBITaxon:9606	Homo sapiens	24	R-HSA-71218	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde	yes	reactome/R-HSA-71218.md	3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS cytosol location for the 3-hydroxyanthranilate + O2 reaction (""Cytosolic 3-hydroxyanthranilate oxygenase ...""). Consistent with the experimental IDA cytosol annotation. Core localization."
human	HACD1	genes/human/HACD1/HACD1-ai-review.yaml	HACD1	B0YJ81	NCBITaxon:9606	Homo sapiens	11	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway-level annotation placing HACD1 in synthesis of very-long-chain fatty acyl-CoAs. This is a correct process-level assignment but is a broader pathway framing than HACD1's specific dehydration step; the core enzymatic role is captured by GO:0102158 / fatty acid elongation. Keep as non-core.
human	HACD1	genes/human/HACD1/HACD1-ai-review.yaml	HACD1	B0YJ81	NCBITaxon:9606	Homo sapiens	17	R-HSA-5676637	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA	yes	reactome/R-HSA-5676637.md	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome author-stated ER membrane localization for the PTPL/HACD dehydration reaction, consistent with the experimental and UniProt evidence. Accept.
human	HACD2	genes/human/HACD2/HACD2-ai-review.yaml	HACD2	Q6Y1H2	NCBITaxon:9606	Homo sapiens	14	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway-context annotation for the VLCFA acyl-CoA synthesis pathway. Consistent with HACD2's role in elongation but is a broad/adjacent process term; the direct process is fatty acid elongation / VLCFA biosynthesis. Kept as non-core.
human	HACD2	genes/human/HACD2/HACD2-ai-review.yaml	HACD2	Q6Y1H2	NCBITaxon:9606	Homo sapiens	20	R-HSA-5676637	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA	yes	reactome/R-HSA-5676637.md	PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct localization, asserted by Reactome for the dehydration reaction of the VLCFA elongation pathway. Consistent with experimental evidence.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	30	R-HSA-77254	(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H	yes	reactome/R-HSA-77254.md	(S)-3-Hydroxydodecanoyl-CoA+NAD => 3-Oxododecanoyl-CoA+NADH+H	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing HADH in the mitochondrial matrix as part of a beta-oxidation reaction (3-hydroxydodecanoyl-CoA oxidation). Correct, specific localization consistent with UniProt.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	31	R-HSA-77312	(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H	yes	reactome/R-HSA-77312.md	(S)-Hydroxybutanoyl-CoA+NAD => Acetoacetyl-CoA+NADH+H	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization within the short-chain (3-hydroxybutanoyl-CoA) beta-oxidation reaction. Correct and consistent with the curated location.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	32	R-HSA-77323	(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H	yes	reactome/R-HSA-77323.md	(S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization within the hexanoyl-CoA beta-oxidation reaction. Correct, consistent with curated location.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	33	R-HSA-77331	(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H	yes	reactome/R-HSA-77331.md	(S)-Hydroxyoctanoyl-CoA+NAD => 3-Oxooctanoyl-CoA+NADH+H	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization within the octanoyl-CoA beta-oxidation reaction. Correct, consistent with curated location.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	34	R-HSA-77342	(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H	yes	reactome/R-HSA-77342.md	(S)-Hydroxydecanoyl-CoA+NAD => 3-Oxodecanoyl-CoA+NADH+H	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization within the decanoyl-CoA beta-oxidation reaction. Correct, consistent with curated location.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	35	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	This Reactome reaction is 'CLPXP binds mitochondrial matrix proteins'; HADH is annotated here as a matrix substrate of the quality-control protease, which correctly localizes it to the matrix. The location assertion is valid; it does not imply any protease/degradation function for HADH itself.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	36	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome 'LONP1 degrades mitochondrial matrix proteins'; HADH appears as a matrix substrate, correctly localizing it to the matrix. Location-only evidence, not a degradation function of HADH.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	37	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome 'LONP1 binds mitochondrial matrix proteins'; HADH appears as a matrix substrate. Correct localization; location-only, not a HADH function.
human	HADH	genes/human/HADH/HADH-ai-review.yaml	HADH	Q16836	NCBITaxon:9606	Homo sapiens	38	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome 'CLPXP degrades mitochondrial matrix proteins'; HADH appears as a matrix substrate. Correct localization; location-only, not a HADH function.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	37	R-HSA-1482775	MLCL is acylated to CL by HADH (IM)	yes	reactome/R-HSA-1482775.md	MLCL is acylated to CL by HADH (IM)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (MLCL acylation to CL by HADH at the inner membrane). Correct localization.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	38	R-HSA-77271	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA	yes	reactome/R-HSA-77271.md	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a beta-oxidation reaction at the mitochondrial inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	39	R-HSA-77277	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA	yes	reactome/R-HSA-77277.md	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for the enoyl-CoA hydratase reaction (HADHA's own activity) at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	40	R-HSA-77283	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H	yes	reactome/R-HSA-77283.md	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for the 3-hydroxyacyl-CoA dehydrogenase reaction (HADHA's own activity) at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	41	R-HSA-77301	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA	yes	reactome/R-HSA-77301.md	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a C16 hydratase reaction at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	42	R-HSA-77303	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H	yes	reactome/R-HSA-77303.md	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a C16 dehydrogenase reaction at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	43	R-HSA-77304	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA	yes	reactome/R-HSA-77304.md	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a thiolase reaction at the inner membrane. Localization is correct for HADHA via complex membership even though the thiolase step is catalyzed by HADHB.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	44	R-HSA-77309	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA	yes	reactome/R-HSA-77309.md	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a beta-oxidation reaction at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	45	R-HSA-77321	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA	yes	reactome/R-HSA-77321.md	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a beta-oxidation reaction at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	46	R-HSA-77329	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA	yes	reactome/R-HSA-77329.md	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a beta-oxidation reaction at the inner membrane.
human	HADHA	genes/human/HADHA/HADHA-ai-review.yaml	HADHA	P40939	NCBITaxon:9606	Homo sapiens	47	R-HSA-77340	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA	yes	reactome/R-HSA-77340.md	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for a beta-oxidation reaction at the inner membrane.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	33	R-HSA-1482775	MLCL is acylated to CL by HADH (IM)	yes	reactome/R-HSA-1482775.md	MLCL is acylated to CL by HADH (IM)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway curation.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	34	R-HSA-77271	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA	yes	reactome/R-HSA-77271.md	3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for beta-oxidation of tetradecanoyl-CoA.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	35	R-HSA-77277	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA	yes	reactome/R-HSA-77277.md	trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Note this Reactome entry (hydratase reaction) would be more appropriate for HADHA, but the localization itself is correct for both subunits since they form an obligate complex.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	36	R-HSA-77283	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H	yes	reactome/R-HSA-77283.md	(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. Note this Reactome entry (dehydrogenase reaction) would be more appropriate for HADHA, but the localization is correct.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	37	R-HSA-77301	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA	yes	reactome/R-HSA-77301.md	trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	38	R-HSA-77303	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H	yes	reactome/R-HSA-77303.md	(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	39	R-HSA-77304	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA	yes	reactome/R-HSA-77304.md	3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway (thiolase reaction). This correctly reflects HADHB's thiolase activity at the inner membrane.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	40	R-HSA-77309	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA	yes	reactome/R-HSA-77309.md	3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	41	R-HSA-77321	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA	yes	reactome/R-HSA-77321.md	3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	42	R-HSA-77329	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA	yes	reactome/R-HSA-77329.md	3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HADHB	genes/human/HADHB/HADHB-ai-review.yaml	HADHB	P55084	NCBITaxon:9606	Homo sapiens	43	R-HSA-77340	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA	yes	reactome/R-HSA-77340.md	3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	HAL	genes/human/HAL/HAL-ai-review.yaml	HAL	P42357	NCBITaxon:9606	Homo sapiens	11	R-HSA-70921	Histidine catabolism	yes	reactome/R-HSA-70921.md	Histidine catabolism	Homo sapiens	GO:0006548	L-histidine catabolic process	TAS	involved_in	BP	false		ACCEPT	Author statement (TAS) from Reactome's Histidine catabolism pathway. HAL catalyzes the first step of this pathway. Correct core biological process.
human	HAL	genes/human/HAL/HAL-ai-review.yaml	HAL	P42357	NCBITaxon:9606	Homo sapiens	13	R-HSA-70899	histidine => urocanate + NH4+	yes	reactome/R-HSA-70899.md	histidine => urocanate + NH4+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Author statement (TAS) from Reactome localizing HAL to the cytosol, where it catalyzes histidine to urocanate + NH4+. Consistent with HAL being a soluble cytosolic enzyme. Correct cellular location; preferred over the more general cytoplasm IEA annotation.
human	HAO1	genes/human/HAO1/HAO1-ai-review.yaml	HAO1	Q9UJM8	NCBITaxon:9606	Homo sapiens	14	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"This Reactome annotation reflects the transient cytosolic pool of HAO1 cargo prior to PTS1-dependent peroxisomal import (the ""Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix"" reaction), not the steady-state functional location."
human	HAO1	genes/human/HAO1/HAO1-ai-review.yaml	HAO1	Q9UJM8	NCBITaxon:9606	Homo sapiens	15	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	As above, this Reactome cytosol annotation derives from the peroxisomal protein import pathway (PEX5:cargo docking), representing an import-transit state rather than a steady-state cytosolic localization.
human	HAO1	genes/human/HAO1/HAO1-ai-review.yaml	HAO1	Q9UJM8	NCBITaxon:9606	Homo sapiens	16	R-HSA-389842	HAO1 tetramer oxidizes glycolate to glyoxylate	yes	reactome/R-HSA-389842.md	HAO1 tetramer oxidizes glycolate to glyoxylate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Reactome-curated peroxisomal matrix localization (""HAO1 tetramer oxidizes glycolate to glyoxylate""), consistent with the experimental and UniProt evidence."
human	HAO1	genes/human/HAO1/HAO1-ai-review.yaml	HAO1	Q9UJM8	NCBITaxon:9606	Homo sapiens	17	R-HSA-389862	Conversion of glyoxylate to oxalate	yes	reactome/R-HSA-389862.md	Conversion of glyoxylate to oxalate	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Reactome-curated peroxisomal matrix localization associated with the ""Conversion of glyoxylate to oxalate"" reaction. Correct localization."
human	HAO1	genes/human/HAO1/HAO1-ai-review.yaml	HAO1	Q9UJM8	NCBITaxon:9606	Homo sapiens	18	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome peroxisomal matrix localization (peroxisomal import pathway). Consistent with the mature functional location of HAO1.
human	HBS1L	genes/human/HBS1L/HBS1L-ai-review.yaml	HBS1L	Q9Y450	NCBITaxon:9606	Homo sapiens	14	R-HSA-9948299	Reactome ribosome rescue reaction (HBS1L)	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Reactome curated ribosome-rescue role of HBS1L. Core process.
human	HBS1L	genes/human/HBS1L/HBS1L-ai-review.yaml	HBS1L	Q9Y450	NCBITaxon:9606	Homo sapiens	17	R-HSA-9954919	Reactome ribosome rescue reaction (HBS1L)	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		ACCEPT	Reactome curated GTPase activity in the ribosome-rescue pathway.
human	HBS1L	genes/human/HBS1L/HBS1L-ai-review.yaml	HBS1L	Q9Y450	NCBITaxon:9606	Homo sapiens	18	R-HSA-9954730	Reactome cytosol localization (HBS1L)	yes	reactome/R-HSA-9954730.md	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization, consistent with site of action.
human	HBS1L	genes/human/HBS1L/HBS1L-ai-review.yaml	HBS1L	Q9Y450	NCBITaxon:9606	Homo sapiens	19	R-HSA-9954919	Reactome ribosome rescue reaction (HBS1L)	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization (duplicate context).
human	HBS1L	genes/human/HBS1L/HBS1L-ai-review.yaml	HBS1L	Q9Y450	NCBITaxon:9606	Homo sapiens	28	R-HSA-430028	Reactome cytosol localization (HBS1L)	yes	reactome/R-HSA-430028.md	Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization.
human	HCST	genes/human/HCST/HCST-ai-review.yaml	HCST	Q9UBK5	NCBITaxon:9606	Homo sapiens	17	R-HSA-198983	NKG2D homodimer interacting with ligands	yes	reactome/R-HSA-198983.md	NKG2D homodimer interacting with ligands	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome annotation to plasma membrane is consistent with the NKG2D-DAP10 receptor complex acting at the cell surface.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	50	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins	yes	reactome/R-HSA-3108232.md	SUMO E3 ligases SUMOylate target proteins	Homo sapiens	GO:0016925	protein sumoylation	TAS	involved_in	BP	false		ACCEPT	This Reactome annotation correctly identifies HDAC4 involvement in protein SUMOylation. HDAC4 is itself SUMOylated at K559 and also has SUMO E3 ligase activity.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	54	R-HSA-8952069	HDAC4 deacetylates RUNX3	yes	reactome/R-HSA-8952069.md	HDAC4 deacetylates RUNX3	Homo sapiens	GO:0033558	protein lysine deacetylase activity	TAS	enables	MF	false		ACCEPT	This Reactome annotation for HDAC4 deacetylation of RUNX3 correctly identifies protein lysine deacetylase activity toward a non-histone substrate.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	68	R-HSA-4615872	RANBP2 SUMOylates HDAC4 with SUMO1	yes	reactome/R-HSA-4615872.md	RANBP2 SUMOylates HDAC4 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RANBP2 SUMOylation of HDAC4 with SUMO1 in the nucleoplasm.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	69	R-HSA-4615987	RANBP2 SUMOylates HDAC4 with SUMO2,3	yes	reactome/R-HSA-4615987.md	RANBP2 SUMOylates HDAC4 with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RANBP2 SUMOylation of HDAC4 with SUMO2,3 in the nucleoplasm.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	113	R-HSA-4720432	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3	yes	reactome/R-HSA-4720432.md	HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HDAC4 SUMOylation of LXRbeta with SUMO2,3 in the nucleoplasm.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	114	R-HSA-4720446	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3	yes	reactome/R-HSA-4720446.md	HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HDAC4 SUMOylation of LXRalpha with SUMO2,3 in the nucleoplasm.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	115	R-HSA-8952062	CCND1 recruits HDAC4 to RUNX3	yes	reactome/R-HSA-8952062.md	CCND1 recruits HDAC4 to RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CCND1 recruitment of HDAC4 to RUNX3 in the nucleoplasm.
human	HDAC4	genes/human/HDAC4/HDAC4-ai-review.yaml	HDAC4	P56524	NCBITaxon:9606	Homo sapiens	116	R-HSA-8952069	HDAC4 deacetylates RUNX3	yes	reactome/R-HSA-8952069.md	HDAC4 deacetylates RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HDAC4 deacetylation of RUNX3 in the nucleoplasm.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	70	R-HSA-3371511	HSF1 activation	yes	reactome/R-HSA-3371511.md	HSF1 activation	Homo sapiens	GO:0034605	cellular response to heat	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	HDAC6 participates in heat shock response through HSF1 activation pathway.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	71	R-HSA-5620920	Cargo trafficking to the periciliary membrane	yes	reactome/R-HSA-5620920.md	Cargo trafficking to the periciliary membrane	Homo sapiens	GO:0060271	cilium assembly	TAS	involved_in	BP	false		MODIFY	HDAC6 affects cilium assembly through its role in cilium disassembly via tubulin deacetylation.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	128	R-HSA-5324632	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	yes	reactome/R-HSA-5324632.md	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization in HSF1 activation pathway.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	129	R-HSA-5618331	HDAC6 deacetylates microtubules	yes	reactome/R-HSA-5618331.md	HDAC6 deacetylates microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization in microtubule deacetylation pathway.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	130	R-HSA-9646348	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	yes	reactome/R-HSA-9646348.md	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization in aggrephagy pathway.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	131	R-HSA-9646679	PolyUb-Misfolded proteins bind vimentin to form aggresome	yes	reactome/R-HSA-9646679.md	PolyUb-Misfolded proteins bind vimentin to form aggresome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization in aggresome formation pathway.
human	HDAC6	genes/human/HDAC6/HDAC6-ai-review.yaml	HDAC6	Q9UBN7	NCBITaxon:9606	Homo sapiens	132	R-HSA-9646685	Aggresome dissociates from dynein and microtubule	yes	reactome/R-HSA-9646685.md	Aggresome dissociates from dynein and microtubule	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization in aggresome pathway.
human	HES1	genes/human/HES1/HES1-ai-review.yaml	HES1	Q14469	NCBITaxon:9606	Homo sapiens	122	R-HSA-2220979	NOTCH1 PEST domain mutants stimulate HES1 transcription	yes	reactome/R-HSA-2220979.md	NOTCH1 PEST domain mutants stimulate HES1 transcription	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation places HES1 in the nucleoplasm in the context of NOTCH1 PEST-domain mutants stimulating HES1 transcription.
human	HES1	genes/human/HES1/HES1-ai-review.yaml	HES1	Q14469	NCBITaxon:9606	Homo sapiens	123	R-HSA-8878243	HES1 gene transcription is inhibited by RUNX3	yes	reactome/R-HSA-8878243.md	HES1 gene transcription is inhibited by RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation places HES1 in the nucleoplasm in the context of RUNX3-mediated inhibition of HES1 gene transcription.
human	HES1	genes/human/HES1/HES1-ai-review.yaml	HES1	Q14469	NCBITaxon:9606	Homo sapiens	124	R-HSA-9013711	HES1 gene expression is stimulated by NOTCH4	yes	reactome/R-HSA-9013711.md	HES1 gene expression is stimulated by NOTCH4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome curation places HES1 in the nucleoplasm in the context of NOTCH4-stimulated HES1 gene expression.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	22	R-HSA-9035976	Defective HEXA does not cleave the terminall GalNAc from small HA fragments	yes	reactome/R-HSA-9035976.md	Defective HEXA does not cleave the terminall GalNAc from small HA fragments	Homo sapiens	GO:0004563	beta-N-acetylhexosaminidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of beta-N-acetylhexosaminidase activity. The source reaction describes a defective HEXA variant in hyaluronan metabolism, but the molecular function assigned (beta-N-acetylhexosaminidase activity) is the correct wild-type activity.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	31	R-HSA-1605595	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	yes	reactome/R-HSA-1605595.md	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for the GM2A:GM2 to GM2A:GM3 reaction catalyzed by Hex A. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	32	R-HSA-1605632	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	yes	reactome/R-HSA-1605632.md	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for a glycosphingolipid (Gb4Cer) degradation reaction. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	33	R-HSA-1638053	HEXA cleaves the terminal GlcNAc from keratan sulfate	yes	reactome/R-HSA-1638053.md	HEXA cleaves the terminal GlcNAc from keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for HEXA cleaving terminal GlcNAc from keratan sulfate. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	34	R-HSA-2105001	HEXA cleaves the terminal GalNAc from DS	yes	reactome/R-HSA-2105001.md	HEXA cleaves the terminal GalNAc from DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for HEXA cleaving terminal GalNAc from dermatan sulfate. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	35	R-HSA-2162225	HEXA cleaves the terminal GlcNAc from small HA fragments	yes	reactome/R-HSA-2162225.md	HEXA cleaves the terminal GlcNAc from small HA fragments	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for HEXA cleaving terminal GlcNAc from small hyaluronan fragments. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	36	R-HSA-9840833	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	yes	reactome/R-HSA-9840833.md	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for the GM2A:GA2 to GM2A:LacCer reaction. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	37	R-HSA-9840884	bHEXA,bHEXS hydrolyze GM2A:SM2	yes	reactome/R-HSA-9840884.md	bHEXA,bHEXS hydrolyze GM2A:SM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen for the bHEXA,bHEXS hydrolysis of GM2A:SM2. Core lumen localization.
human	HEXA	genes/human/HEXA/HEXA-ai-review.yaml	HEXA	P06865	NCBITaxon:9606	Homo sapiens	43	R-HSA-9035976	Defective HEXA does not cleave the terminall GalNAc from small HA fragments	yes	reactome/R-HSA-9035976.md	Defective HEXA does not cleave the terminall GalNAc from small HA fragments	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to lysosomal lumen (from the defective-HEXA hyaluronan reaction). Core lumen localization; the location is correct irrespective of the defective-variant framing of the source reaction.
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	32	R-HSA-9035982	Defective HEXB does not cleave the terminal GalNAc from HA fragments	yes	reactome/R-HSA-9035982.md	Defective HEXB does not cleave the terminal GalNAc from HA fragments	Homo sapiens	GO:0004563	beta-N-acetylhexosaminidase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the core catalytic activity (in the context of defective HEXB failing to cleave terminal GalNAc from hyaluronan fragments).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	41	R-HSA-1605595	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	yes	reactome/R-HSA-1605595.md	bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (GM2 degradation reaction context).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	42	R-HSA-1605632	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	yes	reactome/R-HSA-1605632.md	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (glycosphingolipid degradation context).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	43	R-HSA-1638053	HEXA cleaves the terminal GlcNAc from keratan sulfate	yes	reactome/R-HSA-1638053.md	HEXA cleaves the terminal GlcNAc from keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (keratan sulfate degradation context).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	44	R-HSA-2105001	HEXA cleaves the terminal GalNAc from DS	yes	reactome/R-HSA-2105001.md	HEXA cleaves the terminal GalNAc from DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (dermatan sulfate degradation context).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	45	R-HSA-2162225	HEXA cleaves the terminal GlcNAc from small HA fragments	yes	reactome/R-HSA-2162225.md	HEXA cleaves the terminal GlcNAc from small HA fragments	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (hyaluronan fragment degradation context).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	46	R-HSA-9638075	HEXB cleaves the terminal GalNAc from DS	yes	reactome/R-HSA-9638075.md	HEXB cleaves the terminal GalNAc from DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (HEXB cleaving terminal GalNAc from dermatan sulfate).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	47	R-HSA-9638076	HEXB cleaves the terminal GlcNAc from small HA fragments	yes	reactome/R-HSA-9638076.md	HEXB cleaves the terminal GlcNAc from small HA fragments	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (HEXB cleaving terminal GlcNAc from hyaluronan fragments).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	48	R-HSA-9638078	HEXB cleaves the terminal GlcNAc from keratan sulfate	yes	reactome/R-HSA-9638078.md	HEXB cleaves the terminal GlcNAc from keratan sulfate	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (HEXB cleaving terminal GlcNAc from keratan sulfate).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	49	R-HSA-9840833	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	yes	reactome/R-HSA-9840833.md	bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (Hex A/Hex B hydrolysing GM2A:GA2 to GM2A:LacCer).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	50	R-HSA-9840884	bHEXA,bHEXS hydrolyze GM2A:SM2	yes	reactome/R-HSA-9840884.md	bHEXA,bHEXS hydrolyze GM2A:SM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (Hex A/Hex S hydrolysing GM2A:SM2).
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	58	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for extracellular localization via exocytosis of azurophil granule lumen proteins (neutrophil degranulation). Reflects the secreted granule pool.
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	59	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for azurophil granule lumen localization, corroborated by neutrophil proteomics (PMID:25645918). Non-core granule pool.
human	HEXB	genes/human/HEXB/HEXB-ai-review.yaml	HEXB	P07686	NCBITaxon:9606	Homo sapiens	60	R-HSA-9035982	Defective HEXB does not cleave the terminal GalNAc from HA fragments	yes	reactome/R-HSA-9035982.md	Defective HEXB does not cleave the terminal GalNAc from HA fragments	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for lysosomal lumen localization (defective HEXB hyaluronan reaction context).
human	HGD	genes/human/HGD/HGD-ai-review.yaml	HGD	Q93099	NCBITaxon:9606	Homo sapiens	13	R-HSA-71164	HGD dioxygenates homogentisate	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Core cellular component. HGD is a cytosolic enzyme that carries out the homogentisate dioxygenation step in the cytoplasm.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	7	R-HSA-2263492	Defective HGSNAT does not acetylate Heparan chain(1)	yes	reactome/R-HSA-2263492.md	Defective HGSNAT does not acetylate Heparan chain(1)	Homo sapiens	GO:0015019	heparan-alpha-glucosaminide N-acetyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable-author annotation of the exact-match N-acetyltransferase activity, from a reaction representing HGSNAT acetylation of the heparan chain (the ""defective"" reaction node modelling loss of this activity in MPS IIIC). Supports the core catalytic function."
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	8	R-HSA-9036056	Defective HGSNAT does not acetylate Heparan sulfate chain(3)	yes	reactome/R-HSA-9036056.md	Defective HGSNAT does not acetylate Heparan sulfate chain(3)	Homo sapiens	GO:0015019	heparan-alpha-glucosaminide N-acetyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation of the exact-match N-acetyltransferase activity (second Reactome reaction node). Redundant with the other MF annotations and supports the core catalytic function.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	9	R-HSA-2263492	Defective HGSNAT does not acetylate Heparan chain(1)	yes	reactome/R-HSA-2263492.md	Defective HGSNAT does not acetylate Heparan chain(1)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation of lysosomal membrane location. Correct core location, redundant with the experimentally supported CC annotations.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	10	R-HSA-9036056	Defective HGSNAT does not acetylate Heparan sulfate chain(3)	yes	reactome/R-HSA-9036056.md	Defective HGSNAT does not acetylate Heparan sulfate chain(3)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation of lysosomal membrane location (second reaction node). Correct core location, redundant with other CC annotations.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	11	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome annotation of plasma membrane location, from the ""Exocytosis of tertiary granule membrane proteins"" reaction in the neutrophil degranulation pathway. This reflects mobilization of granule-membrane HGSNAT to the cell surface during degranulation rather than the enzyme's core lysosomal site of action. Not wrong in that specific context, but peripheral to HGSNAT's core catalytic role."
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	12	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome annotation of plasma membrane location from the ""Exocytosis of specific granule membrane proteins"" neutrophil-degranulation reaction. As above, reflects degranulation-associated surface exposure rather than the core lysosomal site of action."
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	13	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing HGSNAT in the neutrophil specific granule membrane (neutrophil degranulation pathway). A real cell-type-specific granule localization but peripheral to the core lysosomal catabolic function of the enzyme.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	14	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing HGSNAT in the neutrophil tertiary granule membrane (neutrophil degranulation pathway). A real cell-type-specific granule localization but peripheral to the core lysosomal catabolic function.
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	16	R-HSA-1678660	HGSNAT oligomer acetylates Heparan sulfate chain(3)	yes	reactome/R-HSA-1678660.md	HGSNAT oligomer acetylates Heparan sulfate chain(3)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author annotation of lysosomal membrane location (from the ""HGSNAT oligomer acetylates Heparan sulfate chain"" reaction). Correct core location."
human	HGSNAT	genes/human/HGSNAT/HGSNAT-ai-review.yaml	HGSNAT	Q68CP4	NCBITaxon:9606	Homo sapiens	17	R-HSA-2090085	HGSNAT oligomer acetylates Heparan chain(1)	yes	reactome/R-HSA-2090085.md	HGSNAT oligomer acetylates Heparan chain(1)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author annotation of lysosomal membrane location (from the ""HGSNAT oligomer acetylates Heparan chain"" reaction). Correct core location."
human	HIBADH	genes/human/HIBADH/HIBADH-ai-review.yaml	HIBADH	P31937	NCBITaxon:9606	Homo sapiens	12	R-HSA-508473	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+	yes	reactome/R-HSA-508473.md	methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that HIBADH functions in the mitochondrial matrix (reverse reaction, methylmalonyl semialdehyde + NADH -> beta- hydroxyisobutyrate + NAD+). This is the correct specific compartment for this soluble matrix enzyme.
human	HIBADH	genes/human/HIBADH/HIBADH-ai-review.yaml	HIBADH	P31937	NCBITaxon:9606	Homo sapiens	13	R-HSA-70885	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+	yes	reactome/R-HSA-70885.md	beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (forward reaction, beta-hydroxyisobutyrate + NAD+ -> methylmalonyl semialdehyde + NADH) localizing HIBADH to the mitochondrial matrix. Duplicate of the matrix annotation from the reverse- direction reaction and equally valid.
human	HIBCH	genes/human/HIBCH/HIBCH-ai-review.yaml	HIBCH	Q6NVY1	NCBITaxon:9606	Homo sapiens	6	R-HSA-70895	Branched-chain amino acid catabolism	yes	reactome/R-HSA-70895.md	Branched-chain amino acid catabolism	Homo sapiens	GO:0009083	branched-chain amino acid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of HIBCH in branched-chain amino acid catabolism. HIBCH acts specifically in the valine branch (hydrolysis of 3-hydroxyisobutyryl-CoA), so this broader parent term is correct.
human	HIBCH	genes/human/HIBCH/HIBCH-ai-review.yaml	HIBCH	Q6NVY1	NCBITaxon:9606	Homo sapiens	9	R-HSA-9916727	HIBCH mutants don't synthesize beta-hydroxyisobutyrate	yes	reactome/R-HSA-9916727.md	HIBCH mutants don't synthesize beta-hydroxyisobutyrate	Homo sapiens	GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of 3-hydroxyisobutyryl-CoA hydrolase activity in the context of the HIBCH-deficiency disease pathway (pathogenic variants that lose the ability to synthesize beta-hydroxyisobutyrate).
human	HIBCH	genes/human/HIBCH/HIBCH-ai-review.yaml	HIBCH	Q6NVY1	NCBITaxon:9606	Homo sapiens	13	R-HSA-9916727	HIBCH mutants don't synthesize beta-hydroxyisobutyrate	yes	reactome/R-HSA-9916727.md	HIBCH mutants don't synthesize beta-hydroxyisobutyrate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization within the HIBCH-deficiency disease pathway.
human	HIBCH	genes/human/HIBCH/HIBCH-ai-review.yaml	HIBCH	Q6NVY1	NCBITaxon:9606	Homo sapiens	15	R-HSA-70881	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA	yes	reactome/R-HSA-70881.md	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial matrix localization for the HIBCH-catalyzed reaction (beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA).
human	HINT2	genes/human/HINT2/HINT2-ai-review.yaml	HINT2	Q9BX68	NCBITaxon:9606	Homo sapiens	9	R-HSA-9693214	RHOD binds effectors at the mitochondrial outer membrane	yes	reactome/R-HSA-9693214.md	RHOD binds effectors at the mitochondrial outer membrane	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		REMOVE	"TAS annotation based on Reactome pathway R-HSA-9693214 claiming RHOD binds HINT2 at the mitochondrial outer membrane to trigger Ca2+ influx. The Reactome entry cites ""Chen et al. 2017"" and ""Bagci et al. 2020"". However, this annotation conflicts with multiple lines of evidence showing HINT2 has an N-terminal mitochondrial targeting sequence (aa 1-17 per UniProt) that directs the mature protein to the matrix. The Reactome interpretation may be erroneous or conflating HINT2 with a different protein."
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	38	R-HSA-446205	Synthesis of GDP-mannose	yes	reactome/R-HSA-446205.md	Synthesis of GDP-mannose	Homo sapiens	GO:0009298	GDP-mannose biosynthetic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome TAS placing HK1 in GDP-mannose biosynthesis. HK1 produces mannose 6-phosphate (upstream), but the GDP-mannose pathway proper is synthesized from fructose 6-phosphate and GTP by other enzymes.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	39	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome TAS (Glycolysis) placing HK1 in canonical glycolysis. HK1 catalyzes the committed entry step.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	41	R-HSA-5621888	Defective HK1 does not phosphorylate Glc to form G6P	yes	reactome/R-HSA-5621888.md	Defective HK1 does not phosphorylate Glc to form G6P	Homo sapiens	GO:0004340	glucokinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for glucose-phosphorylating (glucokinase) activity (from the defective-HK1 disease reaction). Reflects HK1's core glucose-to-G6P reaction.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	42	R-HSA-70420	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	yes	reactome/R-HSA-70420.md	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	Homo sapiens	GO:0004340	glucokinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS (HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P) for glucose-phosphorylating activity. HK1 is an annotated member of the enzyme set catalyzing glucose to G6P.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	54	R-HSA-5621888	Defective HK1 does not phosphorylate Glc to form G6P	yes	reactome/R-HSA-5621888.md	Defective HK1 does not phosphorylate Glc to form G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing HK1 to cytosol, consistent with its predominantly cytosolic distribution.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	64	R-HSA-70420	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	yes	reactome/R-HSA-70420.md	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing HK1 to cytosol (glucose-phosphorylation reaction), consistent with its predominantly cytosolic distribution.
human	HK1	genes/human/HK1/HK1-ai-review.yaml	HK1	P19367	NCBITaxon:9606	Homo sapiens	65	R-HSA-9909159	HK1 phosphorylates Mannose to Man6P	yes	reactome/R-HSA-9909159.md	HK1 phosphorylates Mannose to Man6P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing HK1 to cytosol (mannose-phosphorylation reaction). Consistent with its predominantly cytosolic distribution.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	14	R-HSA-196780	Biotin transport and metabolism	yes	reactome/R-HSA-196780.md	Biotin transport and metabolism	Homo sapiens	GO:0006768	biotin metabolic process	TAS	involved_in	BP	false		ACCEPT	"Reactome (TAS) placement of HLCS in ""Biotin transport and metabolism"". HLCS incorporates biotin into apocarboxylases, a central step of biotin metabolism/utilization. Broad but correct."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	15	R-HSA-2993447	HLCS biotinylates 6x(PCCA:PCCB)	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity for the reaction ""HLCS biotinylates 6x(PCCA:PCCB)"" (biotinylation of propionyl-CoA carboxylase). Correct core molecular function on a genuine substrate."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	16	R-HSA-2993799	HLCS biotinylates 6xMCCC1:6xMCCC2	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity for ""HLCS biotinylates 6xMCCC1:6xMCCC2"" (biotinylation of 3-methylcrotonyl-CoA carboxylase). Correct core function on a genuine substrate."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	17	R-HSA-2993802	HLCS biotinylates PC:Mn2+	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity for ""HLCS biotinylates PC:Mn2+"" (biotinylation of pyruvate carboxylase). Correct core function on a genuine substrate."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	18	R-HSA-2993814	HLCS biotinylates ACACA:Mn2+	yes	reactome/R-HSA-2993814.md	HLCS biotinylates ACACA:Mn2+	Homo sapiens	GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity for ""HLCS biotinylates ACACA:Mn2+"" (biotinylation of acetyl-CoA carboxylase 1). Correct core function on a genuine substrate."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	19	R-HSA-3323184	Defective HLCS does not biotinylate ACACA:Mn2+	yes	reactome/R-HSA-3323184.md	Defective HLCS does not biotinylate ACACA:Mn2+	Homo sapiens	GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity within the disease reaction ""Defective HLCS does not biotinylate ACACA:Mn2+"". The annotated activity is the same core ligase function (in a defective-variant context). Correct."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	20	R-HSA-4167511	HLCS biotinylates ACACB	yes	reactome/R-HSA-4167511.md	HLCS biotinylates ACACB	Homo sapiens	GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity for ""HLCS biotinylates ACACB"" (biotinylation of acetyl-CoA carboxylase 2). Correct core function on a genuine substrate."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	21	R-HSA-9035987	Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity within the disease reaction ""Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2"". Same core ligase function in a defective-variant context. Correct."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	22	R-HSA-9035988	Defective HLCS does not biotinylate PC:Mn2+	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity within the disease reaction ""Defective HLCS does not biotinylate PC:Mn2+"". Same core ligase function in a defective-variant context. Correct."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	23	R-HSA-9035990	Defective HLCS does not biotinylate 6x(PCCA:PCCB)	no				GO:0004077	biotin--[biotin carboxyl-carrier protein] ligase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) biotin--protein ligase activity within the disease reaction ""Defective HLCS does not biotinylate 6x(PCCA:PCCB)"". Same core ligase function in a defective-variant context. Correct."
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	24	R-HSA-3323184	Defective HLCS does not biotinylate ACACA:Mn2+	yes	reactome/R-HSA-3323184.md	Defective HLCS does not biotinylate ACACA:Mn2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization. Consistent with the well-documented cytosolic localization of HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	25	R-HSA-9035987	Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization. Duplicate of the well-supported cytosolic localization of HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	26	R-HSA-9035988	Defective HLCS does not biotinylate PC:Mn2+	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization. Duplicate of the well-supported cytosolic localization of HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	27	R-HSA-9035990	Defective HLCS does not biotinylate 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization. Duplicate of the well-supported cytosolic localization of HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	31	R-HSA-2993447	HLCS biotinylates 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the PCC-biotinylation reaction. Consistent with cytosolic HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	32	R-HSA-2993799	HLCS biotinylates 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the MCC-biotinylation reaction. Consistent with cytosolic HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	33	R-HSA-2993802	HLCS biotinylates PC:Mn2+	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the PC-biotinylation reaction. Consistent with cytosolic HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	34	R-HSA-2993814	HLCS biotinylates ACACA:Mn2+	yes	reactome/R-HSA-2993814.md	HLCS biotinylates ACACA:Mn2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the ACACA-biotinylation reaction. Consistent with cytosolic HLCS.
human	HLCS	genes/human/HLCS/HLCS-ai-review.yaml	HLCS	P50747	NCBITaxon:9606	Homo sapiens	35	R-HSA-4167511	HLCS biotinylates ACACB	yes	reactome/R-HSA-4167511.md	HLCS biotinylates ACACB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosolic localization associated with the ACACB-biotinylation reaction. Consistent with cytosolic HLCS.
human	HMBS	genes/human/HMBS/HMBS-ai-review.yaml	HMBS	P08397	NCBITaxon:9606	Homo sapiens	11	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation (Heme biosynthesis pathway) to heme biosynthetic process. Core biological process for HMBS.
human	HMBS	genes/human/HMBS/HMBS-ai-review.yaml	HMBS	P08397	NCBITaxon:9606	Homo sapiens	12	R-HSA-189406	4 PBGs bind to form HMB	yes	reactome/R-HSA-189406.md	4 PBGs bind to form HMB	Homo sapiens	GO:0004418	hydroxymethylbilane synthase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS annotation (reaction ""4 PBGs bind to form HMB"") of hydroxymethylbilane synthase activity. Core catalytic function."
human	HMBS	genes/human/HMBS/HMBS-ai-review.yaml	HMBS	P08397	NCBITaxon:9606	Homo sapiens	18	R-HSA-189406	4 PBGs bind to form HMB	yes	reactome/R-HSA-189406.md	4 PBGs bind to form HMB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to cytosol for the ""4 PBGs bind to form HMB"" reaction. Core location."
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	116	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	HMGB1 localizes to secretory granule lumen.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	117	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		ACCEPT	HMGB1 present in ficolin-1-rich granule lumen.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	118	R-HSA-166072	MyD88 forms a complex with TIRAP:activated TLR2/4	yes	reactome/R-HSA-166072.md	MyD88 forms a complex with TIRAP:activated TLR2/4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 localizes to extracellular region in TLR signaling context.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	119	R-HSA-166082	IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex	yes	reactome/R-HSA-166082.md	IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	120	R-HSA-166091	IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex	yes	reactome/R-HSA-166091.md	IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	121	R-HSA-166119	First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal	yes	reactome/R-HSA-166119.md	First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	122	R-HSA-166284	Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP	yes	reactome/R-HSA-166284.md	Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	123	R-HSA-166286	Multiple IRAK1 autophosphorylation steps	yes	reactome/R-HSA-166286.md	Multiple IRAK1 autophosphorylation steps	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	124	R-HSA-166362	Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	yes	reactome/R-HSA-166362.md	Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	125	R-HSA-166363	TRAF6 binds to hp- IRAK1	yes	reactome/R-HSA-166363.md	TRAF6 binds to hp- IRAK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	126	R-HSA-2201316	Activated TLR2/4 interacts with MAL (TIRAP)	yes	reactome/R-HSA-2201316.md	Activated TLR2/4 interacts with MAL (TIRAP)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	127	R-HSA-2201322	TIRAP is phosphorylated by BTK	yes	reactome/R-HSA-2201322.md	TIRAP is phosphorylated by BTK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	128	R-HSA-2262775	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	yes	reactome/R-HSA-2262775.md	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	129	R-HSA-2262777	TRAF6 binds to p-IRAK2	yes	reactome/R-HSA-2262777.md	TRAF6 binds to p-IRAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	130	R-HSA-2559414	Activated TLR2/4:TIRAP interacts with BTK	yes	reactome/R-HSA-2559414.md	Activated TLR2/4:TIRAP interacts with BTK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	131	R-HSA-5432825	HMGB1 binds TLR4:LY96	yes	reactome/R-HSA-5432825.md	HMGB1 binds TLR4:LY96	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	132	R-HSA-5602353	Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4	yes	reactome/R-HSA-5602353.md	Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	133	R-HSA-5602383	Defective MyD88 does not oligomerize within the activated TLR2/4 complex	yes	reactome/R-HSA-5602383.md	Defective MyD88 does not oligomerize within the activated TLR2/4 complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	134	R-HSA-5602606	Defective MyD88 does not bind MAL(TIRAP):TLR2/4	yes	reactome/R-HSA-5602606.md	Defective MyD88 does not bind MAL(TIRAP):TLR2/4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	135	R-HSA-6804099	HMGB1 binds LTP	yes	reactome/R-HSA-6804099.md	HMGB1 binds LTP	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	136	R-HSA-6804100	HMGB1 binds LPS	yes	reactome/R-HSA-6804100.md	HMGB1 binds LPS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	137	R-HSA-6805981	HMGB1 release from cells	yes	reactome/R-HSA-6805981.md	HMGB1 release from cells	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	138	R-HSA-937022	IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP	yes	reactome/R-HSA-937022.md	IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	139	R-HSA-937059	Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex	yes	reactome/R-HSA-937059.md	Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	140	R-HSA-937079	MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88	yes	reactome/R-HSA-937079.md	MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	180	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	181	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	182	R-HSA-879411	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor	yes	reactome/R-HSA-879411.md	Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	183	R-NUL-997411	AGER binds rat ERK1/2	yes	reactome/R-NUL-997411.md	AGER binds rat ERK1/2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	HMGB1 in extracellular region.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	184	R-HSA-266204	Association of HMGB1/HMGB2 with chromatin	yes	reactome/R-HSA-266204.md	Association of HMGB1/HMGB2 with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HMGB1 in nucleoplasm.
human	HMGB1	genes/human/HMGB1/HMGB1-ai-review.yaml	HMGB1	P09429	NCBITaxon:9606	Homo sapiens	185	R-HSA-6805981	HMGB1 release from cells	yes	reactome/R-HSA-6805981.md	HMGB1 release from cells	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HMGB1 in nucleoplasm.
human	HMGCL	genes/human/HMGCL/HMGCL-ai-review.yaml	HMGCL	P35914	NCBITaxon:9606	Homo sapiens	21	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome peroxisomal-import event placing HMGCL cargo in the peroxisomal matrix after PEX5-mediated translocation. Consistent with the dual-targeting biology.
human	HMGCL	genes/human/HMGCL/HMGCL-ai-review.yaml	HMGCL	P35914	NCBITaxon:9606	Homo sapiens	22	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome annotation places HMGCL in the cytosol as a transient step of the generic PEX5-dependent peroxisomal protein-import pathway (cargo in the cytosol before translocation), not as evidence of a functional cytosolic catalytic pool.
human	HMGCL	genes/human/HMGCL/HMGCL-ai-review.yaml	HMGCL	P35914	NCBITaxon:9606	Homo sapiens	23	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosolic annotation from the PEX5 docking/translocation-module Reactome event; represents the same import-intermediate cytosolic step.
human	HMGCL	genes/human/HMGCL/HMGCL-ai-review.yaml	HMGCL	P35914	NCBITaxon:9606	Homo sapiens	26	R-HSA-74180	HMG CoA => acetoacetic acid + acetyl CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome reaction ""HMG CoA => acetoacetic acid + acetyl CoA"" places the HMGCL dimer in the mitochondrial matrix as the catalytic site."
human	HMGCR	genes/human/HMGCR/HMGCR-ai-review.yaml	HMGCR	P04035	NCBITaxon:9606	Homo sapiens	29	R-HSA-9621410	HMGCR gene expression	yes	reactome/R-HSA-9621410.md	HMGCR gene expression	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of HMGCR to the ER membrane (HMGCR gene expression pathway context).
human	HMGCR	genes/human/HMGCR/HMGCR-ai-review.yaml	HMGCR	P04035	NCBITaxon:9606	Homo sapiens	30	R-HSA-1655826	Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)	yes	reactome/R-HSA-1655826.md	Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of HMGCR to the ER membrane (HMGCR expression pathway context).
human	HMGCR	genes/human/HMGCR/HMGCR-ai-review.yaml	HMGCR	P04035	NCBITaxon:9606	Homo sapiens	31	R-HSA-191352	HMGCR dimer reduces bHMG-CoA to MVA	yes	reactome/R-HSA-191352.md	HMGCR dimer reduces bHMG-CoA to MVA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable assignment of HMGCR to the ER membrane in the reaction ""HMGCR dimer reduces bHMG-CoA to MVA"", the catalytic step of the mevalonate pathway."
human	HMGCR	genes/human/HMGCR/HMGCR-ai-review.yaml	HMGCR	P04035	NCBITaxon:9606	Homo sapiens	32	R-HSA-9705584	HMGCR dimer binds statins	yes	reactome/R-HSA-9705584.md	HMGCR dimer binds statins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable assignment of HMGCR to the ER membrane in the reaction ""HMGCR dimer binds statins""."
human	HMGCS1	genes/human/HMGCS1/HMGCS1-ai-review.yaml	HMGCS1	Q01581	NCBITaxon:9606	Homo sapiens	10	R-HSA-9969896	Lanosterol biosynthesis	yes	reactome/R-HSA-9969896.md	Lanosterol biosynthesis	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Core biological process. Via the mevalonate pathway, HMGCS1-produced HMG-CoA is the committed precursor of cholesterol; Reactome places HMGCS1 in cholesterol (lanosterol) biosynthesis.
human	HMGCS1	genes/human/HMGCS1/HMGCS1-ai-review.yaml	HMGCS1	Q01581	NCBITaxon:9606	Homo sapiens	11	R-HSA-191323	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA	yes	reactome/R-HSA-191323.md	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA	Homo sapiens	GO:0004421	hydroxymethylglutaryl-CoA synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of the core HMG-CoA synthase reaction (condensation of acetyl-CoA and acetoacetyl-CoA to HMG-CoA).
human	HMGCS1	genes/human/HMGCS1/HMGCS1-ai-review.yaml	HMGCS1	Q01581	NCBITaxon:9606	Homo sapiens	17	R-HSA-1655848	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)	yes	reactome/R-HSA-1655848.md	Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of cytosolic localization, consistent with the curated location.
human	HMGCS1	genes/human/HMGCS1/HMGCS1-ai-review.yaml	HMGCS1	Q01581	NCBITaxon:9606	Homo sapiens	18	R-HSA-191323	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA	yes	reactome/R-HSA-191323.md	HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of cytosolic localization (duplicate of the Reactome/HPA cytosol annotations).
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	42	R-HSA-77111	Synthesis of Ketone Bodies	yes	reactome/R-HSA-77111.md	Synthesis of Ketone Bodies	Homo sapiens	GO:0046951	ketone body biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing HMGCS2 in the Synthesis of Ketone Bodies pathway. This is the core biological process of the enzyme.
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	43	R-HSA-73918	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH	no				GO:0004421	hydroxymethylglutaryl-CoA synthase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the HMG-CoA synthase reaction (acetoacetyl-CoA + acetyl-CoA => HMG-CoA + CoASH). Core molecular function.
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	53	R-HSA-1989760	Expression of HMGCS2	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization (Expression of HMGCS2 pathway). This is the precise, correct compartment for the enzyme.
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	54	R-HSA-73918	acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, associated with the HMG-CoA synthase reaction. Correct compartment.
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	55	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in the context of LONP1-mediated degradation of matrix proteins. Correct compartment; annotation reflects HMGCS2 being a matrix substrate of the LONP1 quality-control machinery.
human	HMGCS2	genes/human/HMGCS2/HMGCS2-ai-review.yaml	HMGCS2	P54868	NCBITaxon:9606	Homo sapiens	56	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in the context of LONP1 binding matrix proteins. Correct compartment.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	32	R-HSA-9708558	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane	yes	reactome/R-HSA-9708558.md	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models a stress-induced translocation of HO-1 from the ER to the mitochondrial outer membrane. A secondary, context-dependent sub-pool.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	33	R-HSA-9708536	HMOX1 translocates from the cytosol to the nucleoplasm	yes	reactome/R-HSA-9708536.md	HMOX1 translocates from the cytosol to the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome models nuclear translocation of HO-1. A stress/context-dependent sub-pool of a cleaved form, not the primary location.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	34	R-HSA-9609921	SGTA binds Tail-anchored protein	yes	reactome/R-HSA-9609921.md	SGTA binds Tail-anchored protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol location, consistent with tail-anchored protein handling (SGTA/insertion pathway) and the cytosol-facing catalytic domain / soluble cleaved form.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	35	R-HSA-9708457	HM13 cleaves HMOX1 dimer	yes	reactome/R-HSA-9708457.md	HM13 cleaves HMOX1 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol location associated with HM13-mediated cleavage of the HMOX1 dimer, generating the soluble form.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	36	R-HSA-9708536	HMOX1 translocates from the cytosol to the nucleoplasm	yes	reactome/R-HSA-9708536.md	HMOX1 translocates from the cytosol to the nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol location (precursor step to nuclear translocation).
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	47	R-HSA-189398	HMOX1 dimer, HMOX2 cleave heme	yes	reactome/R-HSA-189398.md	HMOX1 dimer, HMOX2 cleave heme	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (heme cleavage reaction) places the HMOX1 dimer in the ER membrane. Core location.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	48	R-HSA-6797268	Expression of HMOX1	yes	reactome/R-HSA-6797268.md	Expression of HMOX1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (HMOX1 expression) ER membrane location. Core location.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	49	R-HSA-9707645	HMOX1 gene produces HMOX1 dimer	yes	reactome/R-HSA-9707645.md	HMOX1 gene produces HMOX1 dimer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (HMOX1 dimer formation) ER membrane location. Core location.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	50	R-HSA-9708457	HM13 cleaves HMOX1 dimer	yes	reactome/R-HSA-9708457.md	HM13 cleaves HMOX1 dimer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (HM13 cleavage of HMOX1 dimer) ER membrane location. Core location.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	51	R-HSA-9708558	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane	yes	reactome/R-HSA-9708558.md	HMOX1 dimer translocates from ER membrane to mitochondrial outer membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (ER-to-mitochondria translocation step) ER membrane starting location. Core.
human	HMOX1	genes/human/HMOX1/HMOX1-ai-review.yaml	HMOX1	P09601	NCBITaxon:9606	Homo sapiens	52	R-HSA-9759176	NFE2L2-dependent HMOX1 gene expression	yes	reactome/R-HSA-9759176.md	NFE2L2-dependent HMOX1 gene expression	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (NFE2L2-dependent HMOX1 expression) ER membrane location. Core.
human	HMOX2	genes/human/HMOX2/HMOX2-ai-review.yaml	HMOX2	P30519	NCBITaxon:9606	Homo sapiens	14	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil specific-granule exocytosis context places HO-2 at the plasma membrane; over-general relative to the ER-membrane core.
human	HMOX2	genes/human/HMOX2/HMOX2-ai-review.yaml	HMOX2	P30519	NCBITaxon:9606	Homo sapiens	15	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places HO-2 among neutrophil specific-granule membrane proteins; a specialized non-core location.
human	HMOX2	genes/human/HMOX2/HMOX2-ai-review.yaml	HMOX2	P30519	NCBITaxon:9606	Homo sapiens	17	R-HSA-189398	HMOX1 dimer, HMOX2 cleave heme	yes	reactome/R-HSA-189398.md	HMOX1 dimer, HMOX2 cleave heme	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location (Reactome heme-degradation reaction places HO-2 at the ER membrane).
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	37	R-HSA-8950292	Expression of Heterogeneous nuclear ribonucleoproteins A2/B1	yes	reactome/R-HSA-8950292.md	Expression of Heterogeneous nuclear ribonucleoproteins A2/B1	Homo sapiens	GO:0070062	extracellular exosome	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular exosome localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	59	R-HSA-72103	Formation of pre-mRNPs	yes	reactome/R-HSA-72103.md	Formation of pre-mRNPs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	60	R-HSA-9770119	Formation of the Spliceosomal E complex	yes	reactome/R-HSA-9770119.md	Formation of the Spliceosomal E complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	61	R-HSA-9770129	Formation of the Spliceosomal A complex	yes	reactome/R-HSA-9770129.md	Formation of the Spliceosomal A complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	62	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	63	R-HSA-9770132	Formation of the Spliceosomal Pre-B complex	yes	reactome/R-HSA-9770132.md	Formation of the Spliceosomal Pre-B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	64	R-HSA-9770141	Formation of the Spliceosomal C* complex	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	65	R-HSA-9770142	Formation of the Spliceosomal B complex	yes	reactome/R-HSA-9770142.md	Formation of the Spliceosomal B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	66	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	67	R-HSA-9770236	Formation of the Spliceosomal P complex and exon ligation	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	68	R-HSA-9770847	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	69	R-HSA-9794542	Formation of the Spliceosomal C complex containing intron lariat	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	70	R-HSA-9921507	NS5 interacts with Spliceosome	yes	reactome/R-HSA-9921507.md	NS5 interacts with Spliceosome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	71	R-HSA-9970141	Core CPA complex binds capped pre-mRNA	yes	reactome/R-HSA-9970141.md	Core CPA complex binds capped pre-mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	72	R-HSA-9970179	Recruitment of other CPA components to pre-mRNA-bound CPA core	yes	reactome/R-HSA-9970179.md	Recruitment of other CPA components to pre-mRNA-bound CPA core	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	73	R-HSA-9970189	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS	yes	reactome/R-HSA-9970189.md	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	74	R-HSA-9970190	PP1 dephosphorylates RNA Pol II	yes	reactome/R-HSA-9970190.md	PP1 dephosphorylates RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	75	R-HSA-9970191	RBBP6 activates CPSF complex	yes	reactome/R-HSA-9970191.md	RBBP6 activates CPSF complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	76	R-HSA-9970193	CPSF3 cleaves pre-mRNA at distal 3'UTR PAS	yes	reactome/R-HSA-9970193.md	CPSF3 cleaves pre-mRNA at distal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	77	R-HSA-9970282	U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS	yes	reactome/R-HSA-9970282.md	U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	78	R-HSA-9970294	CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS	yes	reactome/R-HSA-9970294.md	CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	79	R-HSA-9970318	PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS	yes	reactome/R-HSA-9970318.md	PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	80	R-HSA-9970320	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS	yes	reactome/R-HSA-9970320.md	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	81	R-HSA-9970428	CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)	yes	reactome/R-HSA-9970428.md	CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	82	R-HSA-9970429	CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)	yes	reactome/R-HSA-9970429.md	CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HNRNPA2B1	genes/human/HNRNPA2B1/HNRNPA2B1-ai-review.yaml	HNRNPA2B1	P22626	NCBITaxon:9606	Homo sapiens	83	R-HSA-9970431	CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)	yes	reactome/R-HSA-9970431.md	CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation.
human	HOGA1	genes/human/HOGA1/HOGA1-ai-review.yaml	HOGA1	Q86XE5	NCBITaxon:9606	Homo sapiens	15	R-HSA-6784423	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate	yes	reactome/R-HSA-6784423.md	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-curated localization of the HOGA1-catalyzed HOG cleavage reaction to the mitochondrial matrix.
human	HPD	genes/human/HPD/HPD-ai-review.yaml	HPD	P32754	NCBITaxon:9606	Homo sapiens	29	R-HSA-71163	HPD dioxygenates HPP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization for the HPD dioxygenation reaction; this is the core functional compartment.
human	HPRT1	genes/human/HPRT1/HPRT1-ai-review.yaml	HPRT1	P00492	NCBITaxon:9606	Homo sapiens	32	R-HSA-9734274	Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (defective-HPRT1 reaction context) placing the enzyme in the cytosol.
human	HPRT1	genes/human/HPRT1/HPRT1-ai-review.yaml	HPRT1	P00492	NCBITaxon:9606	Homo sapiens	36	R-HSA-74215	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP	yes	reactome/R-HSA-74215.md	HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the HPRT1 catalytic reaction in the cytosol.
human	HPRT1	genes/human/HPRT1/HPRT1-ai-review.yaml	HPRT1	P00492	NCBITaxon:9606	Homo sapiens	37	R-HSA-9748951	HPRT1 tetramer transfers phosphoribosyl group to 6MP to form 6TIMP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (6-mercaptopurine/6TIMP reaction context) placing the HPRT1 tetramer in the cytosol.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	22	R-HSA-2168884	Ferriheme is transferred from Methemoglobin to Hemopexin	yes	reactome/R-HSA-2168884.md	Ferriheme is transferred from Methemoglobin to Hemopexin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for heme transfer from methemoglobin to HPX. Confirms extracellular localization where this transfer occurs.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	23	R-HSA-2168886	Hemopexin binds Hemes	yes	reactome/R-HSA-2168886.md	Hemopexin binds Hemes	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HPX binding hemes. Core function occurs in extracellular region.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	24	R-HSA-2168887	Ferriheme is transferred from Albumin to Hemopexin	yes	reactome/R-HSA-2168887.md	Ferriheme is transferred from Albumin to Hemopexin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for heme transfer from albumin to HPX.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	25	R-HSA-2168897	LRP1 (CD91) binds Hemopexin:heme	yes	reactome/R-HSA-2168897.md	LRP1 (CD91) binds Hemopexin:heme	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for LRP1 binding HPX:heme complex at cell surface.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	26	R-HSA-2230983	LRP1:Hemopexin:heme is endocytosed	yes	reactome/R-HSA-2230983.md	LRP1:Hemopexin:heme is endocytosed	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HPX:heme endocytosis. HPX transitions from extracellular to endocytic vesicle.
human	HPX	genes/human/HPX/HPX-ai-review.yaml	HPX	P02790	NCBITaxon:9606	Homo sapiens	27	R-HSA-2230983	LRP1:Hemopexin:heme is endocytosed	yes	reactome/R-HSA-2230983.md	LRP1:Hemopexin:heme is endocytosed	Homo sapiens	GO:0071682	endocytic vesicle lumen	TAS	located_in	CC	false		ACCEPT	After binding LRP1 and being endocytosed, HPX:heme complex is transported through endocytic vesicles. This is part of the heme delivery mechanism.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	80	R-HSA-5673001	TODO: Fetch title	yes	reactome/R-HSA-5673001.md	RAF/MAP kinase cascade	Homo sapiens	GO:0000165	MAPK cascade	TAS	involved_in	BP	false		ACCEPT	HRAS signals through the RAF-MEK-ERK MAPK cascade.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	84	R-HSA-9649736	TODO: Fetch title	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		ACCEPT	HRAS has intrinsic GTPase activity.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	92	R-HSA-9647994	TODO: Fetch title	yes	reactome/R-HSA-9647994.md	RAS proteins are depalmitoylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	93	R-HSA-6802834	TODO: Fetch title	yes	reactome/R-HSA-6802834.md	RAS GTPase mutants don't hydrolyze GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	94	R-HSA-6802908	TODO: Fetch title	yes	reactome/R-HSA-6802908.md	RAS mutants bind inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	95	R-HSA-6802918	TODO: Fetch title	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	96	R-HSA-6802922	TODO: Fetch title	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	97	R-HSA-6802924	TODO: Fetch title	yes	reactome/R-HSA-6802924.md	RAF is phosphorylated downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	98	R-HSA-6802925	TODO: Fetch title	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	99	R-HSA-6802926	TODO: Fetch title	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	100	R-HSA-6802937	TODO: Fetch title	yes	reactome/R-HSA-6802937.md	Inactive BRAF mutants bind mutant RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	101	R-HSA-6802941	TODO: Fetch title	yes	reactome/R-HSA-6802941.md	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	102	R-HSA-6802942	TODO: Fetch title	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	103	R-HSA-6802943	TODO: Fetch title	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	104	R-HSA-6803233	TODO: Fetch title	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	105	R-HSA-6803234	TODO: Fetch title	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	106	R-HSA-6803240	TODO: Fetch title	yes	reactome/R-HSA-6803240.md	Homo- or heterodimerization of RAF downstream of mutant RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	107	R-HSA-8936731	TODO: Fetch title	yes	reactome/R-HSA-8936731.md	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	108	R-HSA-9651280	TODO: Fetch title	yes	reactome/R-HSA-9651280.md	RAS GAP mutants aren't stimulated by GAPs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	109	R-HSA-9647980	TODO: Fetch title	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	HRAS transits and cycles through Golgi membranes during palmitoylation-dependent trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	110	R-HSA-9647982	TODO: Fetch title	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	HRAS transits and cycles through Golgi membranes during palmitoylation-dependent trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	111	R-HSA-9647978	TODO: Fetch title	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Newly prenylated HRAS is processed at the ER membrane (RCE1/ICMT) before onward trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	112	R-HSA-9647999	TODO: Fetch title	yes	reactome/R-HSA-9647999.md	RCE1 cleaves S-Farn proRAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Newly prenylated HRAS is processed at the ER membrane (RCE1/ICMT) before onward trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	113	R-HSA-1168636	TODO: Fetch title	yes	reactome/R-HSA-1168636.md	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	114	R-HSA-1225951	TODO: Fetch title	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	115	R-HSA-1225957	TODO: Fetch title	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	116	R-HSA-1250383	TODO: Fetch title	yes	reactome/R-HSA-1250383.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	117	R-HSA-1306972	TODO: Fetch title	yes	reactome/R-HSA-1306972.md	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	118	R-HSA-1433471	TODO: Fetch title	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	119	R-HSA-170986	TODO: Fetch title	yes	reactome/R-HSA-170986.md	Ral-GDS binds to Ras-GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	120	R-HSA-177938	TODO: Fetch title	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	121	R-HSA-177945	TODO: Fetch title	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	122	R-HSA-186834	TODO: Fetch title	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	123	R-HSA-210977	TODO: Fetch title	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	124	R-HSA-2179407	TODO: Fetch title	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	125	R-HSA-2424477	TODO: Fetch title	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	126	R-HSA-392054	TODO: Fetch title	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	127	R-HSA-5218845	TODO: Fetch title	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	128	R-HSA-5621573	TODO: Fetch title	yes	reactome/R-HSA-5621573.md	CD209 activate GTPase RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	129	R-HSA-5624486	TODO: Fetch title	yes	reactome/R-HSA-5624486.md	SFKs phosphorylates RAF1 on Y340,Y341	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	130	R-HSA-5624492	TODO: Fetch title	yes	reactome/R-HSA-5624492.md	PAK phosphorylates p21 RAF1 on S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	131	R-HSA-5624494	TODO: Fetch title	yes	reactome/R-HSA-5624494.md	RAF1 binds p21 RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	132	R-HSA-5637806	TODO: Fetch title	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	133	R-HSA-5637808	TODO: Fetch title	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	134	R-HSA-5654392	TODO: Fetch title	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	135	R-HSA-5654402	TODO: Fetch title	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	136	R-HSA-5654413	TODO: Fetch title	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	137	R-HSA-5654426	TODO: Fetch title	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	138	R-HSA-5654600	TODO: Fetch title	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	139	R-HSA-5654618	TODO: Fetch title	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	140	R-HSA-5654647	TODO: Fetch title	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	141	R-HSA-5654663	TODO: Fetch title	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	142	R-HSA-5655241	TODO: Fetch title	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	143	R-HSA-5655277	TODO: Fetch title	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	144	R-HSA-5655326	TODO: Fetch title	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	145	R-HSA-5655347	TODO: Fetch title	yes	reactome/R-HSA-5655347.md	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	146	R-HSA-5658231	TODO: Fetch title	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	147	R-HSA-5658435	TODO: Fetch title	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	148	R-HSA-5672950	TODO: Fetch title	yes	reactome/R-HSA-5672950.md	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	149	R-HSA-5672965	TODO: Fetch title	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	150	R-HSA-5672966	TODO: Fetch title	yes	reactome/R-HSA-5672966.md	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	151	R-HSA-5672969	TODO: Fetch title	yes	reactome/R-HSA-5672969.md	Phosphorylation of RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	152	R-HSA-5672972	TODO: Fetch title	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	153	R-HSA-5672973	TODO: Fetch title	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	154	R-HSA-5672978	TODO: Fetch title	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	155	R-HSA-5672980	TODO: Fetch title	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	156	R-HSA-5674018	TODO: Fetch title	yes	reactome/R-HSA-5674018.md	BRAP binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	157	R-HSA-5674022	TODO: Fetch title	yes	reactome/R-HSA-5674022.md	BRAP autoubiquitinates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	158	R-HSA-5675417	TODO: Fetch title	yes	reactome/R-HSA-5675417.md	PEBP1 binds activated RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	159	R-HSA-5675431	TODO: Fetch title	yes	reactome/R-HSA-5675431.md	PP2A dephosphorylates RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	160	R-HSA-5675433	TODO: Fetch title	yes	reactome/R-HSA-5675433.md	PP5 dephosphorylates RAF1 S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	161	R-HSA-6802837	TODO: Fetch title	yes	reactome/R-HSA-6802837.md	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	162	R-HSA-8851827	TODO: Fetch title	yes	reactome/R-HSA-8851827.md	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	163	R-HSA-8851877	TODO: Fetch title	yes	reactome/R-HSA-8851877.md	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	164	R-HSA-8851899	TODO: Fetch title	yes	reactome/R-HSA-8851899.md	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	165	R-HSA-8941613	TODO: Fetch title	yes	reactome/R-HSA-8941613.md	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	166	R-HSA-8941618	TODO: Fetch title	yes	reactome/R-HSA-8941618.md	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	167	R-HSA-8941623	TODO: Fetch title	yes	reactome/R-HSA-8941623.md	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	168	R-HSA-8941628	TODO: Fetch title	yes	reactome/R-HSA-8941628.md	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	169	R-HSA-8981353	TODO: Fetch title	yes	reactome/R-HSA-8981353.md	RASA1 stimulates RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	170	R-HSA-8981355	TODO: Fetch title	yes	reactome/R-HSA-8981355.md	RASA1 binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	171	R-HSA-9607304	TODO: Fetch title	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	172	R-HSA-9632906	TODO: Fetch title	yes	reactome/R-HSA-9632906.md	PRKCZ recruits RAS in response to estrogen stimulation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	173	R-HSA-9632918	TODO: Fetch title	yes	reactome/R-HSA-9632918.md	PRKCZ stimulates RAS nucleotide exchange in response to estrogen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	174	R-HSA-9634418	TODO: Fetch title	yes	reactome/R-HSA-9634418.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	175	R-HSA-9647980	TODO: Fetch title	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	176	R-HSA-9649733	TODO: Fetch title	yes	reactome/R-HSA-9649733.md	mature p21 RAS binds GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	177	R-HSA-9649735	TODO: Fetch title	yes	reactome/R-HSA-9649735.md	Intrinsic nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	178	R-HSA-9649736	TODO: Fetch title	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	179	R-HSA-9653108	TODO: Fetch title	yes	reactome/R-HSA-9653108.md	Raf dimer inhibitors bind RAF heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	180	R-HSA-9656209	TODO: Fetch title	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	181	R-HSA-9656211	TODO: Fetch title	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	182	R-HSA-9656212	TODO: Fetch title	yes	reactome/R-HSA-9656212.md	Phosphorylation of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	183	R-HSA-9656213	TODO: Fetch title	yes	reactome/R-HSA-9656213.md	RAF1 mutants show enhanced heterodimerization with BRAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	184	R-HSA-9656214	TODO: Fetch title	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	185	R-HSA-9656215	TODO: Fetch title	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	186	R-HSA-9657599	TODO: Fetch title	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	187	R-HSA-9657603	TODO: Fetch title	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	188	R-HSA-9657606	TODO: Fetch title	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	189	R-HSA-9657608	TODO: Fetch title	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	190	R-HSA-9658253	TODO: Fetch title	yes	reactome/R-HSA-9658253.md	RAS:GTP binds PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	191	R-HSA-9660557	TODO: Fetch title	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	192	R-HSA-9664991	TODO: Fetch title	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	193	R-HSA-9665009	TODO: Fetch title	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	194	R-HSA-9665404	TODO: Fetch title	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	195	R-HSA-9665408	TODO: Fetch title	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	196	R-HSA-9665700	TODO: Fetch title	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	197	R-HSA-9665707	TODO: Fetch title	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	198	R-HSA-9670436	TODO: Fetch title	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	199	R-HSA-9672163	TODO: Fetch title	yes	reactome/R-HSA-9672163.md	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	200	R-HSA-9672170	TODO: Fetch title	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	201	R-HSA-9695853	TODO: Fetch title	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	202	R-HSA-9703441	TODO: Fetch title	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	203	R-HSA-9647977	TODO: Fetch title	yes	reactome/R-HSA-9647977.md	ICMT methylates S-Farn RAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Newly prenylated HRAS is processed at the ER membrane (RCE1/ICMT) before onward trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	204	R-HSA-9647982	TODO: Fetch title	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Newly prenylated HRAS is processed at the ER membrane (RCE1/ICMT) before onward trafficking, consistent with this Reactome location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	205	R-HSA-9647978	TODO: Fetch title	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	A cytosolic pool of HRAS exists prior to and during membrane targeting, consistent with this Reactome reaction location.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	214	R-HSA-4093331	TODO: Fetch title	yes	reactome/R-HSA-4093331.md	Ras:GTP binds p120-RasGAP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	215	R-HSA-4093339	TODO: Fetch title	yes	reactome/R-HSA-4093339.md	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	216	R-HSA-6802914	TODO: Fetch title	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	217	R-HSA-6802915	TODO: Fetch title	yes	reactome/R-HSA-6802915.md	Moderate kinase activity BRAF mutants bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	218	R-HSA-6802916	TODO: Fetch title	yes	reactome/R-HSA-6802916.md	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	219	R-HSA-6802919	TODO: Fetch title	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	220	R-HSA-6802921	TODO: Fetch title	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	221	R-HSA-6803230	TODO: Fetch title	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	222	R-HSA-8936676	TODO: Fetch title	yes	reactome/R-HSA-8936676.md	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRAS	genes/human/HRAS/HRAS-ai-review.yaml	HRAS	P01112	NCBITaxon:9606	Homo sapiens	223	R-NUL-9617449	TODO: Fetch title	yes	reactome/R-NUL-9617449.md	Rasgrf1 promotes activation of HRAS	Rattus norvegicus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The plasma membrane is the principal signaling location of mature, lipidated HRAS, consistent with these Reactome RAS-pathway reactions.
human	HRC	genes/human/HRC/HRC-ai-review.yaml	HRC	P23327	NCBITaxon:9606	Homo sapiens	9	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome annotation reflects HRC's localization for FAM20C-mediated phosphorylation. The SR lumen is a more specific and accurate term for HRC localization in muscle.
human	HSD11B1	genes/human/HSD11B1/HSD11B1-ai-review.yaml	HSD11B1	P28845	NCBITaxon:9606	Homo sapiens	10	R-HSA-194023	HSD11B2,HSD11B1 dimer oxidise CORT to COR	yes	reactome/R-HSA-194023.md	HSD11B2,HSD11B1 dimer oxidise CORT to COR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER-membrane localization for the HSD11B1-containing reaction. Consistent with all other localization evidence for this enzyme.
human	HSD11B1	genes/human/HSD11B1/HSD11B1-ai-review.yaml	HSD11B1	P28845	NCBITaxon:9606	Homo sapiens	11	R-HSA-9757706	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell	yes	reactome/R-HSA-9757706.md	HSD11B1 hydrogenates PREDN to PREDL in hepatic cell	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted ER-membrane localization for a hepatic HSD11B1 reaction (prednisone to prednisolone reduction). Consistent with all other localization evidence.
human	HSD11B2	genes/human/HSD11B2/HSD11B2-ai-review.yaml	HSD11B2	P80365	NCBITaxon:9606	Homo sapiens	23	R-HSA-194023	HSD11B2,HSD11B1 dimer oxidise CORT to COR	yes	reactome/R-HSA-194023.md	HSD11B2,HSD11B1 dimer oxidise CORT to COR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane, consistent with experimental evidence that HSD11B2 is an ER-membrane-anchored enzyme (its N-terminal anchor determines orientation in the ER membrane). Core cellular localization.
human	HSD11B2	genes/human/HSD11B2/HSD11B2-ai-review.yaml	HSD11B2	P80365	NCBITaxon:9606	Homo sapiens	24	R-HSA-9759259	HSD11B2 dehydrogenates PREDL to PREDN	yes	reactome/R-HSA-9759259.md	HSD11B2 dehydrogenates PREDL to PREDN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane (duplicate term id from a second Reactome reaction). Consistent with the enzyme's ER-membrane residence.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	91	R-HSA-508369	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+	yes	reactome/R-HSA-508369.md	alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization for the isoleucine-catabolism reaction. Consistent with the authoritative matrix localization. Accept.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	92	R-HSA-6787591	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9	yes	reactome/R-HSA-6787591.md	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization for the tRNA m1G9 methylation reaction. Consistent with authoritative matrix localization. Accept.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	93	R-HSA-6787594	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9	yes	reactome/R-HSA-6787594.md	TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization for the tRNA m1A9 methylation reaction. Accept.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	94	R-HSA-70837	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+	yes	reactome/R-HSA-70837.md	alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization for the isoleucine-catabolism (MHBD) reaction. Accept.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	95	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization (LONP1 matrix-protein degradation context). Localization consistent with authoritative matrix localization. Accept.
human	HSD17B10	genes/human/HSD17B10/HSD17B10-ai-review.yaml	HSD17B10	Q99714	NCBITaxon:9606	Homo sapiens	96	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) mitochondrial-matrix localization (LONP1 matrix-protein binding context). Accept.
human	HSD17B12	genes/human/HSD17B12/HSD17B12-ai-review.yaml	HSD17B12	Q53GQ0	NCBITaxon:9606	Homo sapiens	15	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-curated (TAS) placement of HSD17B12/KAR in the synthesis of very-long-chain fatty acyl-CoAs. Correctly captures the biological process of the elongation cycle in which KAR performs the reduction step.
human	HSD17B12	genes/human/HSD17B12/HSD17B12-ai-review.yaml	HSD17B12	Q53GQ0	NCBITaxon:9606	Homo sapiens	25	R-HSA-548818	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA	yes	reactome/R-HSA-548818.md	HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome-curated (TAS) ER membrane localization in the reaction ""HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA"". Correct, specific, core localization."
human	HSD17B3	genes/human/HSD17B3/HSD17B3-ai-review.yaml	HSD17B3	P37058	NCBITaxon:9606	Homo sapiens	12	R-HSA-193048	Androgen biosynthesis	yes	reactome/R-HSA-193048.md	Androgen biosynthesis	Homo sapiens	GO:0006702	androgen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	TAS (Reactome, Androgen biosynthesis) assignment to androgen biosynthetic process. HSD17B3 catalyses the terminal androstenedione->testosterone step of androgen (testosterone) biosynthesis.
human	HSD17B3	genes/human/HSD17B3/HSD17B3-ai-review.yaml	HSD17B3	P37058	NCBITaxon:9606	Homo sapiens	14	R-HSA-193064	HSD17B3-like proteins reducde ANDST to TEST	yes	reactome/R-HSA-193064.md	HSD17B3-like proteins reducde ANDST to TEST	Homo sapiens	GO:0047045	testosterone dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	TAS (Reactome, HSD17B3-like proteins reduce ANDST to TEST) assignment of testosterone dehydrogenase (NADP+) activity, duplicating the core molecular function.
human	HSD17B3	genes/human/HSD17B3/HSD17B3-ai-review.yaml	HSD17B3	P37058	NCBITaxon:9606	Homo sapiens	17	R-HSA-193064	HSD17B3-like proteins reducde ANDST to TEST	yes	reactome/R-HSA-193064.md	HSD17B3-like proteins reducde ANDST to TEST	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to the endoplasmic reticulum membrane, the most precise cellular-component term. HSD17B3 has an N-terminal hydrophobic segment that anchors it in the ER membrane.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	26	R-HSA-192331	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA	yes	reactome/R-HSA-192331.md	3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix in the context of the bile-acid (THCA-CoA hydration) reaction. Correct and the most precise localization term; the peroxisomal matrix is the functional compartment for DBP catalysis.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	27	R-HSA-193455	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA	yes	reactome/R-HSA-193455.md	(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (bile-acid intermediate dehydrogenation reaction). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	28	R-HSA-193508	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA	yes	reactome/R-HSA-193508.md	(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (bile-acid intermediate reaction). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	29	R-HSA-193535	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	yes	reactome/R-HSA-193535.md	25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (bile-acid intermediate hydration reaction). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	30	R-HSA-2066778	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA	yes	reactome/R-HSA-2066778.md	Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (hydration step in DHA-synthesis beta-oxidation). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	31	R-HSA-2066780	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA	yes	reactome/R-HSA-2066780.md	Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (dehydrogenation step in DHA-synthesis beta-oxidation). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	32	R-HSA-389986	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA	yes	reactome/R-HSA-389986.md	trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (pristanoyl-CoA hydration step). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	33	R-HSA-389995	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+	yes	reactome/R-HSA-389995.md	3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (pristanoyl-CoA dehydrogenation step). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	34	R-HSA-390251	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA	yes	reactome/R-HSA-390251.md	HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (VLCFA 3-hydroxyacyl-CoA dehydrogenation step). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	35	R-HSA-390252	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA	yes	reactome/R-HSA-390252.md	HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix (VLCFA enoyl-CoA hydration step). Correct core localization.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	36	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing DBP to the peroxisomal matrix as PEX5 import cargo (translocation from cytosol to matrix). Correct destination compartment for the imported enzyme.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	37	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS placing DBP in the cytosol as newly-synthesized PTS1 cargo before import. This reflects the transient import route, not the functional compartment; DBP acts in the peroxisomal matrix. Non-core.
human	HSD17B4	genes/human/HSD17B4/HSD17B4-ai-review.yaml	HSD17B4	P51659	NCBITaxon:9606	Homo sapiens	38	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS placing DBP in the cytosol as PEX5 cargo binding the docking/translocation module. Import-route intermediate, not the functional compartment. Non-core.
human	HSD3B2	genes/human/HSD3B2/HSD3B2-ai-review.yaml	HSD3B2	P26439	NCBITaxon:9606	Homo sapiens	21	R-HSA-193052	Pregn-5-ene-3,20-dione isomerizes to progesterone	yes	reactome/R-HSA-193052.md	Pregn-5-ene-3,20-dione isomerizes to progesterone	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS: the isomerization of pregn-5-ene-3,20-dione to progesterone is catalyzed by 3-beta-HSD associated with the endoplasmic reticulum membrane. Consistent with the experimentally supported ER-membrane localization.
human	HSD3B2	genes/human/HSD3B2/HSD3B2-ai-review.yaml	HSD3B2	P26439	NCBITaxon:9606	Homo sapiens	22	R-HSA-193073	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST	yes	reactome/R-HSA-193073.md	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS: the two-step oxidation/isomerization of DHEA to androstenedione is catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane.
human	HSD3B2	genes/human/HSD3B2/HSD3B2-ai-review.yaml	HSD3B2	P26439	NCBITaxon:9606	Homo sapiens	23	R-HSA-193961	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone	yes	reactome/R-HSA-193961.md	Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS: isomerization of pregn-5-ene-3,20-dione-17-ol to 17-hydroxyprogesterone is catalyzed by 3-beta-HSD associated with the endoplasmic reticulum membrane.
human	HSD3B2	genes/human/HSD3B2/HSD3B2-ai-review.yaml	HSD3B2	P26439	NCBITaxon:9606	Homo sapiens	24	R-HSA-196350	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione	yes	reactome/R-HSA-196350.md	Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS: NAD+-dependent dehydrogenation of pregnenolone to pregn-5-ene-3,20-dione by 3beta-HSD associated with the endoplasmic reticulum membrane.
human	HSD3B2	genes/human/HSD3B2/HSD3B2-ai-review.yaml	HSD3B2	P26439	NCBITaxon:9606	Homo sapiens	25	R-HSA-196372	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol	yes	reactome/R-HSA-196372.md	17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS: NAD+-dependent dehydrogenation of 17-hydroxypregnenolone to pregn-5-ene-3,20-dione-17-ol by 3beta-HSD associated with the endoplasmic reticulum membrane.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	9	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	HSD3B7 catalyzes the second step of the classic (neutral) bile-acid pathway via 7-alpha-hydroxycholesterol; Reactome annotates its participation in bile acid biosynthesis. This is a core biological process for HSD3B7.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	10	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Participation in bile-acid/bile-salt synthesis via the 24-hydroxycholesterol (acidic/alternative) branch; HSD3B7 performs the 3-beta-dehydrogenation/isomerization step on the 7-alpha-hydroxylated 24-hydroxy sterol. Core bile-acid process annotation.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	11	R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	yes	reactome/R-HSA-193807.md	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Participation in bile-acid/bile-salt synthesis via the 27-hydroxycholesterol branch. HSD3B7 acts on the 7-alpha-hydroxylated 27-hydroxy sterol. Core bile-acid process annotation.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	12	R-HSA-192097	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one	yes	reactome/R-HSA-192097.md	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one	Homo sapiens	GO:0003854	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	TAS	enables	MF	false		ACCEPT	Core molecular function - NAD+-dependent 3-beta-hydroxy-Delta5-steroid dehydrogenase (with associated isomerase activity). Reactome R-HSA-192097 describes HSD3B7 oxidizing/isomerizing 7-alpha-hydroxycholesterol to 4-cholesten-7-alpha-ol-3-one.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	13	R-HSA-193789	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one	yes	reactome/R-HSA-193789.md	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one	Homo sapiens	GO:0003854	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	TAS	enables	MF	false		ACCEPT	Same core 3-beta-hydroxy-Delta5-steroid dehydrogenase activity, annotated from the Reactome reaction on cholest-5-ene-3beta,7alpha,24(S)-triol (the 24-hydroxy branch substrate).
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	14	R-HSA-193816	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one	yes	reactome/R-HSA-193816.md	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one	Homo sapiens	GO:0003854	3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity	TAS	enables	MF	false		ACCEPT	Same core 3-beta-hydroxy-Delta5-steroid dehydrogenase activity, annotated from the Reactome reaction on cholest-5-ene-3beta,7alpha,27-triol (the 27-hydroxy branch substrate).
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	19	R-HSA-192097	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one	yes	reactome/R-HSA-192097.md	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER-membrane localization asserted by Reactome for the HSD3B7-catalyzed reaction. Consistent with UniProt (multi-pass ER membrane) and the microsomal enzyme described in PMID:11067870. Core localization.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	20	R-HSA-193789	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one	yes	reactome/R-HSA-193789.md	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate ER-membrane localization from another Reactome reaction for HSD3B7. Core localization.
human	HSD3B7	genes/human/HSD3B7/HSD3B7-ai-review.yaml	HSD3B7	Q9H2F3	NCBITaxon:9606	Homo sapiens	21	R-HSA-193816	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one	yes	reactome/R-HSA-193816.md	Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate ER-membrane localization from another Reactome reaction for HSD3B7. Core localization.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	58	R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	yes	reactome/R-HSA-3371497.md	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Homo sapiens	GO:0071383	cellular response to steroid hormone stimulus	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	HSPA1A participates in the HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Reactome:R-HSA-3371497). Hsp70 binds nascent/misfolded steroid hormone receptors and hands them off to HSP90 via HOP/STIP1.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	60	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	ATP hydrolysis by HSP70 is a Reactome-curated reaction (R-HSA-3371422). This is the core enzymatic activity of HSPA1A, confirmed by IDA (PMID:21231916) and IBA evidence.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	131	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotates HSPA1A in the extracellular region via pathway R-HSA-6800434 (neutrophil degranulation). Consistent with known extracellular Hsp70.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	132	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-6800434 places HSPA1A in ficolin-1-rich granule lumen as part of neutrophil degranulation.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	137	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-3371467). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	138	R-HSA-3371518	SIRT1 binds to HSF1	yes	reactome/R-HSA-3371518.md	SIRT1 binds to HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-3371518). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	139	R-HSA-3371554	HSF1 acetylation at Lys80	yes	reactome/R-HSA-3371554.md	HSF1 acetylation at Lys80	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-3371554). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	140	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-5082356). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	141	R-HSA-5082369	Acetylated HSF1 dissociates from DNA	yes	reactome/R-HSA-5082369.md	Acetylated HSF1 dissociates from DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-5082369). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	142	R-HSA-5082384	HSP70:DNAJB1 binds HSF1	yes	reactome/R-HSA-5082384.md	HSP70:DNAJB1 binds HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-5082384). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	143	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-5251955). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	144	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	yes	reactome/R-HSA-5252041.md	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway (Reactome:R-HSA-5252041). HSPA1A is known to translocate to the nucleus during heat stress and participates in nuclear HSF1 regulation and HSP90 chaperone cycles.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	145	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-3371422). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	146	R-HSA-3371503	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-3371503). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	147	R-HSA-3371590	HSP70 binds to HSP40:nascent protein	yes	reactome/R-HSA-3371590.md	HSP70 binds to HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-3371590). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	148	R-HSA-450551	AUF1 binds translation and heat shock proteins	yes	reactome/R-HSA-450551.md	AUF1 binds translation and heat shock proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-450551). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	149	R-HSA-450580	AUF1 (hnRNP D0) is ubiquitinylated	yes	reactome/R-HSA-450580.md	AUF1 (hnRNP D0) is ubiquitinylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-450580). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	150	R-HSA-5251942	Hikeshi binds HSP70s:ATP	yes	reactome/R-HSA-5251942.md	Hikeshi binds HSP70s:ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5251942). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	151	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5251959). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	152	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	yes	reactome/R-HSA-5252041.md	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5252041). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	153	R-HSA-5252079	HSP110s exchange ATP for ADP on HSP70s:ADP	yes	reactome/R-HSA-5252079.md	HSP110s exchange ATP for ADP on HSP70s:ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5252079). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	154	R-HSA-5618085	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618085.md	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5618085). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	155	R-HSA-5618098	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5618098). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	156	R-HSA-5618105	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618105.md	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5618105). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	157	R-HSA-5618107	ATP binding to HSP90 triggers conformation change	yes	reactome/R-HSA-5618107.md	ATP binding to HSP90 triggers conformation change	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5618107). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	158	R-HSA-5618110	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-5618110). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	159	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-9835411). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1A	genes/human/HSPA1A/HSPA1A-ai-review.yaml	HSPA1A	P0DMV8	NCBITaxon:9606	Homo sapiens	160	R-HSA-9857076	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1	yes	reactome/R-HSA-9857076.md	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway (Reactome:R-HSA-9857076). Cytosol is the primary site of HSPA1A chaperone function.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	54	R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	yes	reactome/R-HSA-3371497.md	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Homo sapiens	GO:0071383	cellular response to steroid hormone stimulus	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	TAS from Reactome describing HSP90 chaperone cycle for steroid hormone receptors, in which HSP70 participates by delivering client proteins to the HSP90 complex via HOP/STIP1.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	55	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome entry R-HSA-3371422 describing ATP hydrolysis by HSP70. Core molecular function.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	98	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome R-HSA-6800434 (exocytosis of ficolin-rich granule lumen proteins) describing release of HSP70 into the extracellular space during neutrophil degranulation. HSP70 is known to be released extracellularly via exosomes and neutrophil granules.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	99	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome R-HSA-6800434 describing HSP70 in ficolin-rich granule lumen of neutrophils. Cell-type-specific localization in neutrophils.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	103	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371467 (SIRT1 deacetylates HSF1) describing HSP70 involvement in the nucleoplasm during HSF1-mediated heat shock response regulation. HSP70 shuttles to the nucleus during stress via Hikeshi-mediated import.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	104	R-HSA-3371518	SIRT1 binds to HSF1	yes	reactome/R-HSA-3371518.md	SIRT1 binds to HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371518 (SIRT1 binds to HSF1) describing nucleoplasmic localization of HSP70 in the context of HSF1 regulation. Redundant with other nucleoplasm TAS annotations.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	105	R-HSA-3371554	HSF1 acetylation at Lys80	yes	reactome/R-HSA-3371554.md	HSF1 acetylation at Lys80	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371554 (HSF1 acetylation at Lys80) describing nucleoplasmic localization of HSP70 during the heat shock response attenuation phase.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	106	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5082356 (HSF1-mediated gene expression) describing nucleoplasmic localization of HSP70 during HSF1-dependent transactivation. HSP70 feeds back on HSF1 to attenuate the heat shock response.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	107	R-HSA-5082369	Acetylated HSF1 dissociates from DNA	yes	reactome/R-HSA-5082369.md	Acetylated HSF1 dissociates from DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5082369 (acetylated HSF1 dissociates from DNA) describing HSP70 nucleoplasmic role in HSF1 attenuation.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	108	R-HSA-5082384	HSP70:DNAJB1 binds HSF1	yes	reactome/R-HSA-5082384.md	HSP70:DNAJB1 binds HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5082384 (HSP70:DNAJB1 binds HSF1) describing HSP70 nucleoplasmic function in the attenuation phase of the heat shock response, where HSP70 with DNAJB1 binds to HSF1 to suppress transcription.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	109	R-HSA-5251955	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	yes	reactome/R-HSA-5251955.md	HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5251955 (HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm) describing nucleoplasmic HSP70 ATPase cycle driven by J-domain proteins.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	110	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	yes	reactome/R-HSA-5252041.md	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5252041 (NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm) describing Hikeshi-mediated nuclear import of HSP70 during heat shock.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	111	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371422 (ATP hydrolysis by HSP70) describing cytosolic HSP70 ATPase activity. Core localization for HSPA1B.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	112	R-HSA-3371503	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371503 (STIP1/HOP binds HSP90 and HSP70:HSP40:nascent protein) describing cytosolic HSP70 in the HSP70-HSP90 chaperone relay.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	113	R-HSA-3371590	HSP70 binds to HSP40:nascent protein	yes	reactome/R-HSA-3371590.md	HSP70 binds to HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-3371590 (HSP70 binds to HSP40:nascent protein) describing cytosolic HSP70 initial substrate engagement.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	114	R-HSA-5251942	Hikeshi binds HSP70s:ATP	yes	reactome/R-HSA-5251942.md	Hikeshi binds HSP70s:ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5251942 (Hikeshi binds HSP70s:ATP) describing cytosolic HSP70:ATP binding to Hikeshi for nuclear import during heat stress.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	115	R-HSA-5251959	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	yes	reactome/R-HSA-5251959.md	HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5251959 (HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol) describing cytosolic HSP70 ATPase cycle activation by J-domain proteins.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	116	R-HSA-5252041	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	yes	reactome/R-HSA-5252041.md	NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5252041 (NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm) describing cytosolic origin of HSP70 prior to nuclear import.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	117	R-HSA-5252079	HSP110s exchange ATP for ADP on HSP70s:ADP	yes	reactome/R-HSA-5252079.md	HSP110s exchange ATP for ADP on HSP70s:ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5252079 (HSP110s exchange ATP for ADP on HSP70s:ADP) describing cytosolic nucleotide exchange on HSP70 by HSP110 nucleotide exchange factors.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	118	R-HSA-5618085	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618085.md	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5618085 (FKBP4 binds HSP90:ATP:STIP1:HSP70: nascent protein) describing cytosolic HSP70 in the HSP90 chaperone cycle for steroid hormone receptors.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	119	R-HSA-5618098	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5618098 (p23/PTGES3 binds HSP90:ATP:FKBP5: nascent protein) describing cytosolic localization of HSP70 during HSP90 chaperone cycle.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	120	R-HSA-5618105	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618105.md	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5618105 (FKBP5 binds HSP90:ATP:STIP1:HSP70: nascent protein) describing cytosolic HSP70 in HSP90 chaperone cycle.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	121	R-HSA-5618107	ATP binding to HSP90 triggers conformation change	yes	reactome/R-HSA-5618107.md	ATP binding to HSP90 triggers conformation change	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5618107 (ATP binding to HSP90 triggers conformation change) describing cytosolic localization of HSP70 in the context of HSP90 chaperone machinery.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	122	R-HSA-5618110	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-5618110 (p23/PTGES3 binds HSP90:ATP:FKBP4: nascent protein) describing cytosolic localization of HSP70 during HSP90 chaperone cycle maturation steps.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	123	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9835411 (FA core complex:HSP70s binds PKR) describing cytosolic HSP70 involvement in PKR-mediated signaling.
human	HSPA1B	genes/human/HSPA1B/HSPA1B-ai-review.yaml	HSPA1B	P0DMV9	NCBITaxon:9606	Homo sapiens	124	R-HSA-9857076	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1	yes	reactome/R-HSA-9857076.md	Oxidized DNAJA1 binds HSPA1A,B (HSP70) displacing HSF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome R-HSA-9857076 (oxidized DNAJA1 binds HSPA1A,B displacing HSF1) describing cytosolic HSP70 involved in redox-sensitive HSF1 regulation.
human	HSPA1L	genes/human/HSPA1L/HSPA1L-ai-review.yaml	HSPA1L	P34931	NCBITaxon:9606	Homo sapiens	30	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation for nucleoplasm localization based on Reactome pathway R-HSA-5082356 (HSF1-mediated gene expression). The Reactome pathway describes HSF1-driven upregulation of heat shock genes and places HSP70 family members in the nucleoplasm in the context of heat shock response regulation. HSF1 is ""best known for rapid stress-induced upregulation of certain genes related to protein folding, such as HSPA1A/HSP70"" (Reactome:R-HSA-5082356). While HSPA1L is not itself heat-inducible, it is included in this Reactome pathway as an HSP70 family member. Nuclear/nucleoplasmic localization is consistent with the IBA annotation for nucleus."
human	HSPA6	genes/human/HSPA6/HSPA6-ai-review.yaml	HSPA6	P17066	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation of GO:0005576 (extracellular region) from Reactome pathway R-HSA-6798748 (Exocytosis of secretory granule lumen proteins). This annotation indicates HSPA6 is found in the extracellular space, presumably after release from neutrophil secretory granules. HSP70 proteins can be released extracellularly, particularly from immune cells. This is a plausible but non-core localization for HSPA6, which primarily functions as an intracellular chaperone.
human	HSPA6	genes/human/HSPA6/HSPA6-ai-review.yaml	HSPA6	P17066	NCBITaxon:9606	Homo sapiens	22	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation of GO:0005576 (extracellular region) from Reactome pathway R-HSA-6800434 (Exocytosis of ficolin-rich granule lumen proteins). Same rationale as the R-HSA-6798748 annotation above -- HSPA6 may be released extracellularly from neutrophil granules, but this is not a core localization.
human	HSPA6	genes/human/HSPA6/HSPA6-ai-review.yaml	HSPA6	P17066	NCBITaxon:9606	Homo sapiens	23	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation of GO:0034774 (secretory granule lumen) from Reactome pathway R-HSA-6798748 (Exocytosis of secretory granule lumen proteins). This indicates HSPA6 is found in neutrophil secretory granule lumens. HSP70 proteins have been detected in neutrophil granules. This is a specialized localization for an immune cell context, not a core localization for HSPA6.
human	HSPA6	genes/human/HSPA6/HSPA6-ai-review.yaml	HSPA6	P17066	NCBITaxon:9606	Homo sapiens	24	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation of GO:1904813 (ficolin-1-rich granule lumen) from Reactome pathway R-HSA-6800434 (Exocytosis of ficolin-rich granule lumen proteins). This is a specific sub-type of neutrophil granule. Similar rationale to the secretory granule lumen annotation -- this is a specialized immune cell localization.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	94	R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	yes	reactome/R-HSA-3371497.md	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	Homo sapiens	GO:0071383	cellular response to steroid hormone stimulus	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	HSPA8 participates in the HSP90 chaperone cycle for steroid hormone receptors (Reactome). This is a non-core chaperoning role.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	95	R-HSA-199991	Membrane Trafficking	yes	reactome/R-HSA-199991.md	Membrane Trafficking	Homo sapiens	GO:0061024	membrane organization	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	HSPA8 is involved in membrane organization through its role in clathrin-mediated vesicle trafficking and uncoating (Reactome:R-HSA-199991).
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	107	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	ATP hydrolysis is the core enzymatic activity of HSPA8, driving the chaperone cycle. Reactome pathway confirms this.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	108	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	ATP hydrolysis is the core enzymatic activity of HSPA8, driving the chaperone cycle. Reactome pathway confirms this.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	144	R-HSA-8932221	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8	yes	reactome/R-HSA-8932221.md	METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	145	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found in the extracellular region, including secretory granule contents and ficolin-1-rich granules released by neutrophils.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	146	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found in the extracellular region, including secretory granule contents and ficolin-1-rich granules released by neutrophils.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	147	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found in secretory granule lumen (Reactome). This reflects its presence as a protein released during degranulation.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	148	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found in ficolin-1-rich granule lumen (Reactome), reflecting its presence in neutrophil granules.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	186	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	187	R-HSA-3371518	SIRT1 binds to HSF1	yes	reactome/R-HSA-3371518.md	SIRT1 binds to HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	188	R-HSA-3371554	HSF1 acetylation at Lys80	yes	reactome/R-HSA-3371554.md	HSF1 acetylation at Lys80	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	189	R-HSA-5082356	HSF1-mediated gene expression	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	190	R-HSA-5082369	Acetylated HSF1 dissociates from DNA	yes	reactome/R-HSA-5082369.md	Acetylated HSF1 dissociates from DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	191	R-HSA-5082384	HSP70:DNAJB1 binds HSF1	yes	reactome/R-HSA-5082384.md	HSP70:DNAJB1 binds HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	192	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	193	R-HSA-9770141	Formation of the Spliceosomal C* complex	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	194	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	195	R-HSA-9770236	Formation of the Spliceosomal P complex and exon ligation	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	196	R-HSA-9770847	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	197	R-HSA-9772351	Disassembly of the Intron Lariat Spliceosome (new)	yes	reactome/R-HSA-9772351.md	Disassembly of the Intron Lariat Spliceosome (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	198	R-HSA-9794542	Formation of the Spliceosomal C complex containing intron lariat	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HSPA8 is found in the nucleoplasm as part of the PRP19-CDC5L spliceosomal complex and HSF1 regulatory complexes.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	203	R-HSA-888589	Release of GABA at the synapse	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of HSPA8, supported by its role in clathrin-coated vesicle dynamics at the plasma membrane.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	204	R-HSA-888589	Release of GABA at the synapse	yes	reactome/R-HSA-888589.md	Release of GABA at the synapse	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found at clathrin-sculpted GABA transport vesicle membranes (Reactome), reflecting its general role in clathrin-coated vesicle dynamics.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	205	R-HSA-917744	GABA loaded synaptic vesicle Docking and Priming	yes	reactome/R-HSA-917744.md	GABA loaded synaptic vesicle Docking and Priming	Homo sapiens	GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	HSPA8 is found at clathrin-sculpted GABA transport vesicle membranes (Reactome), reflecting its general role in clathrin-coated vesicle dynamics.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	206	R-HSA-3371422	ATP hydrolysis by HSP70	yes	reactome/R-HSA-3371422.md	ATP hydrolysis by HSP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	207	R-HSA-3371503	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	208	R-HSA-3371590	HSP70 binds to HSP40:nascent protein	yes	reactome/R-HSA-3371590.md	HSP70 binds to HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	209	R-HSA-421836	trans-Golgi Network Derived Vesicle Uncoating	yes	reactome/R-HSA-421836.md	trans-Golgi Network Derived Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	210	R-HSA-432688	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	yes	reactome/R-HSA-432688.md	trans-Golgi Network Derived Lysosomal Vesicle Uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	211	R-HSA-450551	AUF1 binds translation and heat shock proteins	yes	reactome/R-HSA-450551.md	AUF1 binds translation and heat shock proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	212	R-HSA-450580	AUF1 (hnRNP D0) is ubiquitinylated	yes	reactome/R-HSA-450580.md	AUF1 (hnRNP D0) is ubiquitinylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	213	R-HSA-5618085	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618085.md	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	214	R-HSA-5618098	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	215	R-HSA-5618105	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	yes	reactome/R-HSA-5618105.md	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	216	R-HSA-5618107	ATP binding to HSP90 triggers conformation change	yes	reactome/R-HSA-5618107.md	ATP binding to HSP90 triggers conformation change	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	217	R-HSA-5618110	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	218	R-HSA-6797269	Expression of HSPA8, ALOX15	yes	reactome/R-HSA-6797269.md	Expression of HSPA8, ALOX15	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	219	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	220	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA8	genes/human/HSPA8/HSPA8-ai-review.yaml	HSPA8	P11142	NCBITaxon:9606	Homo sapiens	221	R-HSA-9835411	FA core complex:HSP70s binds PKR	yes	reactome/R-HSA-9835411.md	FA core complex:HSP70s binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization confirmed by multiple Reactome pathways. HSPA8 is primarily cytosolic.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	60	R-HSA-8950389	Expression of Stress-70 protein, mitochondrial	yes	reactome/R-HSA-8950389.md	Expression of Stress-70 protein, mitochondrial	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (expression of mitochondrial Stress-70 protein). Consistent with the primary matrix localization of HSPA9.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	61	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (CLPXP binds mitochondrial matrix proteins event). Consistent with HSPA9's primary matrix localization where it cooperates with matrix proteostasis machinery.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	62	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (LONP1 degrades mitochondrial matrix proteins event). Consistent with HSPA9's primary matrix localization within the matrix proteostasis network.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	63	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (LONP1 binds mitochondrial matrix proteins event). Consistent with HSPA9's primary matrix localization.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	64	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (CLPXP degrades mitochondrial matrix proteins event). Consistent with HSPA9's primary matrix localization.
human	HSPA9	genes/human/HSPA9/HSPA9-ai-review.yaml	HSPA9	P38646	NCBITaxon:9606	Homo sapiens	65	R-HSA-9856627	ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)	yes	reactome/R-HSA-9856627.md	ATF5 and HSF1 trimer activate expression of HSPA9 (mtHSP70)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (ATF5 and HSF1 trimer activate expression of HSPA9/mtHSP70 event). Consistent with HSPA9's primary matrix localization and stress-responsive upregulation.
human	HSPB8	genes/human/HSPB8/HSPB8-ai-review.yaml	HSPB8	Q9UJY1	NCBITaxon:9606	Homo sapiens	31	R-HSA-5082356	Reactome annotation (nucleoplasm localization of HSPB8)	yes	reactome/R-HSA-5082356.md	HSF1-mediated gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-curated nucleoplasm localization, consistent with the HPA IDA nucleoplasm annotation and HSPB8's nuclear pool.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	92	R-HSA-8869558	HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer	yes	reactome/R-HSA-8869558.md	HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	93	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	94	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	95	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	96	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPD1	genes/human/HSPD1/HSPD1-ai-review.yaml	HSPD1	P10809	NCBITaxon:9606	Homo sapiens	97	R-HSA-9856666	ATF5 and HSF1 trimer activate expression of HSPD1	yes	reactome/R-HSA-9856666.md	ATF5 and HSF1 trimer activate expression of HSPD1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The mitochondrial matrix is the principal chaperonin compartment.
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	20	R-HSA-9940993	PXYLP1 dephosphorylates Xyl moiety	yes	reactome/R-HSA-9940993.md	PXYLP1 dephosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for heparan sulfate biosynthesis (PXYLP1 dephosphorylates Xyl moiety). Perlecan transits through the Golgi during biosynthesis where heparan sulfate chains undergo extensive modifications. This is a transient biosynthetic localization.
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	21	R-HSA-9941039	FAM20B phosphorylates Xyl moiety	yes	reactome/R-HSA-9941039.md	FAM20B phosphorylates Xyl moiety	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for heparan sulfate biosynthesis (FAM20B phosphorylates Xyl moiety). Perlecan transits through the Golgi during biosynthesis where heparan sulfate chains undergo enzymatic modifications. Transient biosynthetic localization.
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	24	R-HSA-1592314	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)	yes	reactome/R-HSA-1592314.md	HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)"". This documents perlecan degradation by matrix metalloproteinases and plasmin in the extracellular region, which is perlecan's native location."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	25	R-HSA-2534240	HSPG2 (perlecan) degradation by MMP14, MMP15	yes	reactome/R-HSA-2534240.md	HSPG2 (perlecan) degradation by MMP14, MMP15	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""HSPG2 (perlecan) degradation by MMP14, MMP15"". This documents perlecan degradation by additional matrix metalloproteinases in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	26	R-HSA-4088220	Endorepellin binds alpha2beta1 integrin	yes	reactome/R-HSA-4088220.md	Endorepellin binds alpha2beta1 integrin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Endorepellin binds alpha2beta1 integrin"". This documents the binding of endorepellin (perlecan domain V fragment) to integrin α2β1, which occurs in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	27	R-HSA-4088281	Endorepellin binds KDR (VEGFR2)	yes	reactome/R-HSA-4088281.md	Endorepellin binds KDR (VEGFR2)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Endorepellin binds KDR (VEGFR2)"". This documents the binding of endorepellin to VEGFR2, a critical interaction for endorepellin's anti-angiogenic activity occurring in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	28	R-NUL-2534170	Degradation of HSPG2 by Mmp13 and Ctss	yes	reactome/R-NUL-2534170.md	Degradation of HSPG2 by Mmp13 and Ctss	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Degradation of HSPG2 by Mmp13 and Ctss"". This documents perlecan degradation by MMP13 and cathepsin S in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	60	R-HSA-3814820	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1	yes	reactome/R-HSA-3814820.md	HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1"". Documents proteolytic processing of perlecan in the extracellular region by BMP1-tolloid metalloproteinases and cathepsin L to generate endorepellin."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	61	R-HSA-2396337	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	yes	reactome/R-HSA-2396337.md	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""HSPG2 binds FGF2(10-155), Fibronectin matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer"". Documents perlecan's binding interactions with growth factors and ECM proteins occurring in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	62	R-HSA-2396395	HSPG2 (perlecan) binds alpha-dystroglycan	yes	reactome/R-HSA-2396395.md	HSPG2 (perlecan) binds alpha-dystroglycan	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""HSPG2 (perlecan) binds alpha-dystroglycan"". Documents perlecan's interaction with dystroglycan, which occurs in the extracellular region at sites like the neuromuscular junction."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	63	R-HSA-4084505	Laminins bind HSPG2	yes	reactome/R-HSA-4084505.md	Laminins bind HSPG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Laminins bind HSPG2"". Documents perlecan's binding to laminins, critical basement membrane proteins, occurring in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	64	R-HSA-976734	Amyloid fibrils have additional components	yes	reactome/R-HSA-976734.md	Amyloid fibrils have additional components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Amyloid fibrils have additional components"". Documents perlecan as a component of amyloid plaques in Alzheimer's disease, which form in the extracellular region."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	65	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""DGC complex binds AGRN and HSPG2"". Documents perlecan's binding to the dystroglycan complex (DGC) and agrin in the extracellular region at the neuromuscular junction."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	66	R-HSA-1878002	XYLTs transfer Xyl to core protein	yes	reactome/R-HSA-1878002.md	XYLTs transfer Xyl to core protein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""XYLTs transfer Xyl to core protein"". This documents the first step of heparan sulfate tetrasaccharide linker synthesis in the Golgi, where perlecan transits during biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	67	R-HSA-1889981	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-1889981.md	B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker"". Documents heparan sulfate linker biosynthesis in Golgi during perlecan glycosylation."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	68	R-HSA-3560804	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	yes	reactome/R-HSA-3560804.md	Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker"". Documents disease pathway affecting perlecan glycosylation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	70	R-HSA-1667005	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)"". Documents degradation of perlecan's heparan sulfate chains by heparanase in lysosomes during turnover."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	71	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS-GAGs translocate to the lysosome for degradation"". Documents transport of heparan sulfate proteoglycans including perlecan to lysosomes for degradation."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	72	R-HSA-2022851	EXT1:EXT2 transfers GlcNAc to the heparan chain	yes	reactome/R-HSA-2022851.md	EXT1:EXT2 transfers GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""EXT1:EXT2 transfers GlcNAc to the heparan chain"". Documents heparan sulfate chain elongation in Golgi during perlecan biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	73	R-HSA-2022856	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2022856.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""EXT1:EXT2 transfers GlcA to heparan"". Documents heparan sulfate chain elongation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	74	R-HSA-2022860	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	yes	reactome/R-HSA-2022860.md	NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate"". Documents HS sulfation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	75	R-HSA-2022887	NDST1-4 N-deacetylates GlcNAc residues in heparan	yes	reactome/R-HSA-2022887.md	NDST1-4 N-deacetylates GlcNAc residues in heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""NDST1-4 N-deacetylates GlcNAc residues in heparan"". Documents HS modification in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	76	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Some HSPGs are secreted to the plasma membrane"". Documents trafficking of perlecan through Golgi to secretion."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	77	R-HSA-2076383	HS3ST1 sulfates GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076383.md	HS3ST1 sulfates GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS3ST1 sulfates GlcN at C3 in heparan sulfate"". Documents HS sulfation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	78	R-HSA-2076392	EXT1:EXT2 transfers GlcA to heparan	yes	reactome/R-HSA-2076392.md	EXT1:EXT2 transfers GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""EXT1:EXT2 transfers GlcA to heparan"". Documents HS chain elongation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	79	R-HSA-2076419	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	yes	reactome/R-HSA-2076419.md	HS6STs sulfate GlcN at C6 in heparan sulfate/heparin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS6STs sulfate GlcN at C6 in heparan sulfate/heparin"". Documents HS sulfation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	80	R-HSA-2076508	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	yes	reactome/R-HSA-2076508.md	HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate"". Documents HS sulfation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	81	R-HSA-2076611	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	yes	reactome/R-HSA-2076611.md	HS3ST2-6 sulfate GlcN at C3 in heparan sulfate	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS3ST2-6 sulfate GlcN at C3 in heparan sulfate"". Documents HS sulfation in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	82	R-HSA-3656254	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656254.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT2 does not transfer GlcNAc to heparan chain"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	83	R-HSA-3656257	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656257.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT1 does not transfer GlcA to heparan"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	84	R-HSA-3656261	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	yes	reactome/R-HSA-3656261.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcNAc to the heparan chain	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT1 does not transfer GlcNAc to heparan chain"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	85	R-HSA-3656267	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-3656267.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT2 does not transfer GlcA to heparan"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	86	R-HSA-9036285	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036285.md	Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT1 does not transfer GlcA to heparan"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	87	R-HSA-9036289	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	yes	reactome/R-HSA-9036289.md	Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective EXT2 does not transfer GlcA to heparan"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	88	R-HSA-9953259	EXTL3 dimer transfers GlcNAc to the GAG linker	yes	reactome/R-HSA-9953259.md	EXTL3 dimer transfers GlcNAc to the GAG linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""EXTL3 dimer transfers GlcNAc to the GAG linker"". Documents HS linker synthesis in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	89	R-HSA-1678694	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	yes	reactome/R-HSA-1678694.md	Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans"". Documents HPSE2 binding to HSPGs including perlecan."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	90	R-HSA-2024084	HS-GAGs translocate to the lysosome for degradation	yes	reactome/R-HSA-2024084.md	HS-GAGs translocate to the lysosome for degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""HS-GAGs translocate to the lysosome for degradation"". Documents trafficking of HSPGs from plasma membrane to lysosomes."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	91	R-HSA-2024108	Some HSPGs are secreted to the plasma membrane	yes	reactome/R-HSA-2024108.md	Some HSPGs are secreted to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Some HSPGs are secreted to the plasma membrane"". Documents secretion of HSPGs."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	92	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol"". Documents lipoprotein uptake involving HSPGs and LRP receptors at the plasma membrane."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	93	R-HSA-2423785	CR:atREs binds apoE and HSPG	yes	reactome/R-HSA-2423785.md	CR:atREs binds apoE and HSPG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""CR:atREs binds apoE and HSPG"". Documents carotenoid-retinoid complexes binding apoE and HSPGs."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	94	R-HSA-2429643	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	yes	reactome/R-HSA-2429643.md	NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs"". Documents metabolism of internalized lipids involving HSPGs."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	95	R-HSA-9694579	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	yes	reactome/R-HSA-9694579.md	Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell"". Documents SARS-CoV-2 interaction with cell surface HSPGs during viral entry."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	96	R-HSA-9694661	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9694661.md	TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"". Documents SARS-CoV-2 viral entry involving HSPGs."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	97	R-HSA-9698988	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	yes	reactome/R-HSA-9698988.md	Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Direct Host Cell Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid"". Documents SARS-CoV-2 viral entry."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	98	R-HSA-9699007	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	yes	reactome/R-HSA-9699007.md	FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"". Documents SARS-CoV-2 viral entry involving HSPGs."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	99	R-HSA-9836899	sG binds to HSPGs	yes	reactome/R-HSA-9836899.md	sG binds to HSPGs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""sG binds to HSPGs"". Documents viral glycoprotein (sG) binding to heparan sulfate proteoglycans."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	100	R-HSA-1667005	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	yes	reactome/R-HSA-1667005.md	Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)"". Actually documents lysosomal degradation, not Golgi localization."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	101	R-HSA-1889955	B3GAT dimers transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-1889955.md	B3GAT dimers transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""B3GAT dimers transfer GlcA to tetrasaccharide linker"". Documents HS linker biosynthesis in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	102	R-HSA-1889978	B3GALT6 transfers Gal to the tetrasaccharide linker	yes	reactome/R-HSA-1889978.md	B3GALT6 transfers Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""B3GALT6 transfers Gal to the tetrasaccharide linker"". Documents HS linker biosynthesis in Golgi."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	103	R-HSA-3560802	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	yes	reactome/R-HSA-3560802.md	Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker"". Documents disease mutations affecting HS biosynthesis."
human	HSPG2	genes/human/HSPG2/HSPG2-ai-review.yaml	HSPG2	P98160	NCBITaxon:9606	Homo sapiens	104	R-HSA-4420365	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	yes	reactome/R-HSA-4420365.md	Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker"". Documents disease mutations affecting HS biosynthesis."
human	IBSP	genes/human/IBSP/IBSP-ai-review.yaml	IBSP	P21815	NCBITaxon:9606	Homo sapiens	20	R-HSA-265427	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)	yes	reactome/R-HSA-265427.md	Interaction of integrin alphaVbeta3 with IPSP (Bone sialoprotein 2)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places IBSP extracellularly during binding to cell-surface integrin alpha-V/beta-3.
human	ICMT	genes/human/ICMT/ICMT-ai-review.yaml	ICMT	O60725	NCBITaxon:9606	Homo sapiens	14	R-HSA-6788650	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins	yes	reactome/R-HSA-6788650.md	ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction (ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins) places the enzyme in the ER membrane. Consistent with experimental localization.
human	ICMT	genes/human/ICMT/ICMT-ai-review.yaml	ICMT	O60725	NCBITaxon:9606	Homo sapiens	15	R-HSA-9647977	ICMT methylates S-Farn RAS proteins	yes	reactome/R-HSA-9647977.md	ICMT methylates S-Farn RAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction (ICMT methylates S-Farn RAS proteins) places ICMT in the ER membrane. Consistent with the core localization.
human	ICMT	genes/human/ICMT/ICMT-ai-review.yaml	ICMT	O60725	NCBITaxon:9606	Homo sapiens	16	R-HSA-9656775	Cysmethynil binds ICMT:Zn2+	yes	reactome/R-HSA-9656775.md	Cysmethynil binds ICMT:Zn2+	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction (Cysmethynil binds ICMT:Zn2+) modeling inhibitor binding to the ER-membrane enzyme. Localization consistent with experimental data.
human	IDH3B	genes/human/IDH3B/IDH3B-ai-review.yaml	IDH3B	O43837	NCBITaxon:9606	Homo sapiens	16	R-HSA-70967	IDH3 complex decarboxylates isocitrate	yes	reactome/R-HSA-70967.md	IDH3 complex decarboxylates isocitrate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome pathway R-HSA-70967 ""IDH3 complex decarboxylates isocitrate"" places the IDH3 complex, including IDH3B, in the mitochondrial matrix. This is the most specific and accurate localization for IDH3B's function."
human	IDI1	genes/human/IDI1/IDI1-ai-review.yaml	IDI1	Q13907	NCBITaxon:9606	Homo sapiens	13	R-HSA-1655823	Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	yes	reactome/R-HSA-1655823.md	Expression of Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) cytosolic localization. Reactome models the IPP-to-DMAPP isomerase step as cytosolic (R-HSA-191382) while noting peroxisomal localization is also reported. Cytosolic activity of the mevalonate/isoprenoid pathway is well established, so this is retained as a genuine, if non-core, location alongside the peroxisome.
human	IDI1	genes/human/IDI1/IDI1-ai-review.yaml	IDI1	Q13907	NCBITaxon:9606	Homo sapiens	14	R-HSA-191382	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate	yes	reactome/R-HSA-191382.md	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) cytosolic localization associated with the reaction event ""Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate"". Duplicate of the other Reactome cytosol annotation; retained as a genuine non-core location."
human	IDI2	genes/human/IDI2/IDI2-ai-review.yaml	IDI2	Q9BXS1	NCBITaxon:9606	Homo sapiens	14	R-HSA-191382	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate	yes	reactome/R-HSA-191382.md	Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) cytosolic localization associated with the reaction event ""Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate"", which Reactome models as cytosolic while noting that IPP isomerase may also be peroxisomal. Cytosolic activity of the mevalonate/isoprenoid pathway is well established, so this is retained as a genuine, non-core location alongside the experimentally supported peroxisome."
human	IDO1	genes/human/IDO1/IDO1-ai-review.yaml	IDO1	P14902	NCBITaxon:9606	Homo sapiens	17	R-HSA-198563	IDO1 dioxygenates L-Trp to NFK	yes	reactome/R-HSA-198563.md	IDO1 dioxygenates L-Trp to NFK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosolic localization of the active enzyme, consistent with UniProt SUBCELLULAR LOCATION (Cytoplasm, cytosol).
human	IDS	genes/human/IDS/IDS-ai-review.yaml	IDS	P22304	NCBITaxon:9606	Homo sapiens	14	R-HSA-2262743	Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)	yes	reactome/R-HSA-2262743.md	Defective IDS does not hydrolyse dermatan sulfate (Chebi:63517 chain)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS (defective IDS reaction) placing IDS in the lysosomal lumen. IDS is a soluble luminal lysosomal hydrolase, so this compartment is correct.
human	IDS	genes/human/IDS/IDS-ai-review.yaml	IDS	P22304	NCBITaxon:9606	Homo sapiens	15	R-HSA-9036046	Defective IDS does not hydrolyse Heparan sulfate chain(5)	yes	reactome/R-HSA-9036046.md	Defective IDS does not hydrolyse Heparan sulfate chain(5)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS (defective IDS in heparan sulfate degradation) placing IDS in the lysosomal lumen. Correct compartment for this soluble hydrolase.
human	IDS	genes/human/IDS/IDS-ai-review.yaml	IDS	P22304	NCBITaxon:9606	Homo sapiens	16	R-HSA-1678650	IDS hydrolyses Heparan sulfate chain(5)	yes	reactome/R-HSA-1678650.md	IDS hydrolyses Heparan sulfate chain(5)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS (IDS hydrolyses heparan sulfate) placing IDS in the lysosomal lumen, the site of heparan sulfate degradation.
human	IDS	genes/human/IDS/IDS-ai-review.yaml	IDS	P22304	NCBITaxon:9606	Homo sapiens	17	R-HSA-1793182	IDS hydrolyses dermatan sulfate (Chebi:63517 chain)	yes	reactome/R-HSA-1793182.md	IDS hydrolyses dermatan sulfate (Chebi:63517 chain)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS (IDS hydrolyses dermatan sulfate) placing IDS in the lysosomal lumen, the site of dermatan sulfate degradation.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	12	R-HSA-2024096	HS-GAG degradation	yes	reactome/R-HSA-2024096.md	HS-GAG degradation	Homo sapiens	GO:0030200	heparan sulfate proteoglycan catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing IDUA in the HS-GAG degradation pathway. Concordant with the experimentally supported role in heparan sulfate catabolism.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	13	R-HSA-1793186	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	yes	reactome/R-HSA-1793186.md	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	Homo sapiens	GO:0030209	dermatan sulfate proteoglycan catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing IDUA in dermatan sulfate degradation (hydrolysis of the unsulfated alpha-L-iduronosidic link in DS). Concordant with the enzyme's EC 3.2.1.76 reaction.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	14	R-HSA-1678716	IDUA cleaves iduronate from HS chain	yes	reactome/R-HSA-1678716.md	IDUA cleaves iduronate from HS chain	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity (cleavage of terminal L-iduronate from HS chains). Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	15	R-HSA-1793186	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	yes	reactome/R-HSA-1793186.md	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity (hydrolysis of the unsulfated alpha-L-iduronosidic link in DS). Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	16	R-HSA-2090037	IDUA hydrolyses Heparan sulfate chain(6)	yes	reactome/R-HSA-2090037.md	IDUA hydrolyses Heparan sulfate chain(6)	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity within a heparan sulfate chain hydrolysis reaction. Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	17	R-HSA-2206299	Defective IDUA does not hydrolyse Heparan sulfate chain(6)	yes	reactome/R-HSA-2206299.md	Defective IDUA does not hydrolyse Heparan sulfate chain(6)	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity (associated with a defective-IDUA/disease reaction). Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	18	R-HSA-9036037	Defective IDUA does not hydrolyse Heparan sulfate chain(1)	yes	reactome/R-HSA-9036037.md	Defective IDUA does not hydrolyse Heparan sulfate chain(1)	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity within a heparan-sulfate-chain reaction. Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	19	R-HSA-9036041	Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS	yes	reactome/R-HSA-9036041.md	Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS	Homo sapiens	GO:0003940	L-iduronidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author assertion of L-iduronidase activity (associated with the defective-IDUA dermatan sulfate reaction). Core molecular function.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	25	R-HSA-2206299	Defective IDUA does not hydrolyse Heparan sulfate chain(6)	yes	reactome/R-HSA-2206299.md	Defective IDUA does not hydrolyse Heparan sulfate chain(6)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (disease reaction context). Correct core compartment.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	26	R-HSA-9036037	Defective IDUA does not hydrolyse Heparan sulfate chain(1)	yes	reactome/R-HSA-9036037.md	Defective IDUA does not hydrolyse Heparan sulfate chain(1)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (heparan sulfate reaction context). Correct core compartment.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	27	R-HSA-9036041	Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS	yes	reactome/R-HSA-9036041.md	Defective IDUA does not hydrolyse the unsulfated alpha-L-iduronosidic link in DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (dermatan sulfate reaction context). Correct core compartment.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	28	R-HSA-1678716	IDUA cleaves iduronate from HS chain	yes	reactome/R-HSA-1678716.md	IDUA cleaves iduronate from HS chain	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (HS chain cleavage reaction). Correct core compartment.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	29	R-HSA-1793186	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	yes	reactome/R-HSA-1793186.md	IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (DS link hydrolysis reaction). Correct core compartment.
human	IDUA	genes/human/IDUA/IDUA-ai-review.yaml	IDUA	P35475	NCBITaxon:9606	Homo sapiens	30	R-HSA-2090037	IDUA hydrolyses Heparan sulfate chain(6)	yes	reactome/R-HSA-2090037.md	IDUA hydrolyses Heparan sulfate chain(6)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of IDUA to the lysosomal lumen (heparan sulfate chain reaction). Correct core compartment.
human	IFI16	genes/human/IFI16/IFI16-ai-review.yaml	IFI16	Q16666	NCBITaxon:9606	Homo sapiens	51	R-HSA-1834951	IFI16 binds cytosolic dsDNA	yes	reactome/R-HSA-1834951.md	IFI16 binds cytosolic dsDNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway R-HSA-1834951 describes IFI16 binding cytosolic dsDNA, supporting cytosolic localization. This is functionally relevant for DNA sensing.
human	IFI30	genes/human/IFI30/IFI30-ai-review.yaml	IFI30	P13284	NCBITaxon:9606	Homo sapiens	12	R-HSA-2132295	MHC class II antigen presentation	yes	reactome/R-HSA-2132295.md	MHC class II antigen presentation	Homo sapiens	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS	involved_in	BP	false		ACCEPT	GILT's role in MHC class II antigen processing is its primary biological function. Reactome pathway annotation is well-supported by primary literature.
human	IFI30	genes/human/IFI30/IFI30-ai-review.yaml	IFI30	P13284	NCBITaxon:9606	Homo sapiens	15	R-HSA-1031716	Expression of IFNG-stimulated genes	yes	reactome/R-HSA-1031716.md	Expression of IFNG-stimulated genes	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	"GILT is localized to the lysosomal lumen where it functions at acidic pH. This Reactome annotation provides more specific localization than ""lysosome."""
human	IFI30	genes/human/IFI30/IFI30-ai-review.yaml	IFI30	P13284	NCBITaxon:9606	Homo sapiens	16	R-HSA-2213240	Reduction of disulphide bonds in MHC II antigens	yes	reactome/R-HSA-2213240.md	Reduction of disulphide bonds in MHC II antigens	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome annotation for lysosomal lumen localization from the pathway specifically describing GILT's function in disulfide reduction.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	70	R-HSA-5696600	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1	yes	reactome/R-HSA-5696600.md	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	75	R-HSA-168909	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS	yes	reactome/R-HSA-168909.md	viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58 bind MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	76	R-HSA-168934	MAVS interacts with RIPK1 and FADD	yes	reactome/R-HSA-168934.md	MAVS interacts with RIPK1 and FADD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	77	R-HSA-913725	viral dsRNA binds IFIH1:TKFC	yes	reactome/R-HSA-913725.md	viral dsRNA binds IFIH1:TKFC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	78	R-HSA-918225	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	yes	reactome/R-HSA-918225.md	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	79	R-HSA-918227	Recruitment of TRAF3 to MAVS	yes	reactome/R-HSA-918227.md	Recruitment of TRAF3 to MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	80	R-HSA-918229	Phosphorylation and release of IRF3/IRF7	yes	reactome/R-HSA-918229.md	Phosphorylation and release of IRF3/IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	81	R-HSA-918230	Recruitment of TRAF6/TRAF2 to MAVS	yes	reactome/R-HSA-918230.md	Recruitment of TRAF6/TRAF2 to MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	82	R-HSA-918232	Recruitment of IRF3,IRF7	yes	reactome/R-HSA-918232.md	Recruitment of IRF3,IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	83	R-HSA-933523	Dimerzation of procaspase-8, procaspase-10	yes	reactome/R-HSA-933523.md	Dimerzation of procaspase-8, procaspase-10	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	84	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	85	R-HSA-933526	Recruitment of caspase-8 and -10 to FADD complex	yes	reactome/R-HSA-933526.md	Recruitment of caspase-8 and -10 to FADD complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	86	R-HSA-933527	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	yes	reactome/R-HSA-933527.md	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	87	R-HSA-933530	Activation of IKK by MEKK1	yes	reactome/R-HSA-933530.md	Activation of IKK by MEKK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	88	R-HSA-933532	Processing of caspases	yes	reactome/R-HSA-933532.md	Processing of caspases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	89	R-HSA-933537	Recruitment of TANK to TRAF6	yes	reactome/R-HSA-933537.md	Recruitment of TANK to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	90	R-HSA-933538	Recruitment of IRF7 to TRAF6	yes	reactome/R-HSA-933538.md	Recruitment of IRF7 to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	91	R-HSA-933539	Recruitment of IKK complex	yes	reactome/R-HSA-933539.md	Recruitment of IKK complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	92	R-HSA-936381	OTUD5 deubiquitinates TRAF3	yes	reactome/R-HSA-936381.md	OTUD5 deubiquitinates TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	93	R-HSA-936475	Negative regulation of DDX58/IFIH1 signaling by RNF216	yes	reactome/R-HSA-936475.md	Negative regulation of DDX58/IFIH1 signaling by RNF216	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	94	R-HSA-937343	NLRC5 interacts with DDX58/IFIH1	yes	reactome/R-HSA-937343.md	NLRC5 interacts with DDX58/IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	95	R-HSA-9705137	TBK1 or IKBKE forms homodimers	yes	reactome/R-HSA-9705137.md	TBK1 or IKBKE forms homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	96	R-HSA-9705145	TBK1, IKBKE form homodimers	yes	reactome/R-HSA-9705145.md	TBK1, IKBKE form homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	97	R-HSA-9705320	TBK1, IKBKE are autophosphorylated at Ser172	yes	reactome/R-HSA-9705320.md	TBK1, IKBKE are autophosphorylated at Ser172	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	98	R-HSA-9705323	Phosphorylation of TBK1/IKBKE	yes	reactome/R-HSA-9705323.md	Phosphorylation of TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	99	R-HSA-9754745	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates	yes	reactome/R-HSA-9754745.md	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	100	R-HSA-9755244	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1	yes	reactome/R-HSA-9755244.md	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	101	R-HSA-9833393	N interacts with IFIH1	yes	reactome/R-HSA-9833393.md	N interacts with IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	102	R-HSA-990526	Recruitment of ITCH and K48 ubiquitination of MAVS	yes	reactome/R-HSA-990526.md	Recruitment of ITCH and K48 ubiquitination of MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	103	R-HSA-990528	Interaction of PCBP2 with MAVS	yes	reactome/R-HSA-990528.md	Interaction of PCBP2 with MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	104	R-HSA-9920772	prM binds IFIH1	yes	reactome/R-HSA-9920772.md	prM binds IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	105	R-HSA-9924831	IFI27 binds IFIH1	yes	reactome/R-HSA-9924831.md	IFI27 binds IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIH1	genes/human/IFIH1/IFIH1-ai-review.yaml	IFIH1	Q9BYX4	NCBITaxon:9606	Homo sapiens	106	R-NUL-936401	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1	yes	reactome/R-NUL-936401.md	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome pathway curation.
human	IFIT2	genes/human/IFIT2/IFIT2-ai-review.yaml	IFIT2	P09913	NCBITaxon:9606	Homo sapiens	21	R-HSA-1015702	Expression of IFN-induced genes	yes	reactome/R-HSA-1015702.md	Expression of IFN-induced genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation confirming cytosolic localization during IFN response.
human	IFIT3	genes/human/IFIT3/IFIT3-ai-review.yaml	IFIT3	O14879	NCBITaxon:9606	Homo sapiens	38	R-HSA-1015702	Expression of IFN-induced genes	yes	reactome/R-HSA-1015702.md	Expression of IFN-induced genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization in IFN response.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	22	R-HSA-381466	Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS	yes	reactome/R-HSA-381466.md	Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	24	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endoplasmic reticulum lumen localization is plausible for a secreted precursor and FAM20C substrate, but it is not the main functional site of mature IGFBP3.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	26	R-HSA-381435	Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS	yes	reactome/R-HSA-381435.md	Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	27	R-HSA-381446	Thrombin proteolyzes IGF:IGFBP3:ALS	yes	reactome/R-HSA-381446.md	Thrombin proteolyzes IGF:IGFBP3:ALS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	28	R-HSA-381461	Plasmin proteolyzes IGF:IGFBP-3:ALS	yes	reactome/R-HSA-381461.md	Plasmin proteolyzes IGF:IGFBP-3:ALS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	29	R-HSA-381496	Formation of the IGF:IGFBP3:ALS complex	yes	reactome/R-HSA-381496.md	Formation of the IGF:IGFBP3:ALS complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	30	R-HSA-381500	Cathepsin G proteolyzes IGF:IGFBP3:ALS	yes	reactome/R-HSA-381500.md	Cathepsin G proteolyzes IGF:IGFBP3:ALS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	31	R-HSA-6800035	IGFBP3 binds TMEM219	yes	reactome/R-HSA-6800035.md	IGFBP3 binds TMEM219	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IGFBP3	genes/human/IGFBP3/IGFBP3-ai-review.yaml	IGFBP3	P17936	NCBITaxon:9606	Homo sapiens	32	R-HSA-6800044	TP53 stimulates IGFBP3 expression	yes	reactome/R-HSA-6800044.md	TP53 stimulates IGFBP3 expression	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported by IGFBP3 secretion and its extracellular/circulating IGF complex functions.
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	74	R-HSA-449803	IL10 dimer binds IL10RA:JAK1	yes	reactome/R-HSA-449803.md	IL10 dimer binds IL10RA:JAK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS annotation for extracellular region from Reactome (IL10 dimer binds IL10RA:JAK1). IL-10 is a secreted protein.
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	75	R-HSA-449811	IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2	yes	reactome/R-HSA-449811.md	IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	76	R-HSA-449855	IL10 dimerizes	yes	reactome/R-HSA-449855.md	IL10 dimerizes	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (IL10 dimerizes).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	77	R-HSA-6784006	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	yes	reactome/R-HSA-6784006.md	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (STAT3 phosphorylation by JAK1/TYK2).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	78	R-HSA-6784319	JAK1,TYK2 phosphorylate JAK1,TYK2	yes	reactome/R-HSA-6784319.md	JAK1,TYK2 phosphorylate JAK1,TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (JAK1,TYK2 phosphorylation).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	79	R-HSA-6784323	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	yes	reactome/R-HSA-6784323.md	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (receptor complex binds STAT3).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	80	R-HSA-6784324	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA	yes	reactome/R-HSA-6784324.md	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (IL10RA phosphorylation).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	81	R-HSA-6784791	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-6784791.md	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (STAT3 dissociation from receptor).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	82	R-HSA-6789615	Expression of STAT3-upregulated extracellular proteins	yes	reactome/R-HSA-6789615.md	Expression of STAT3-upregulated extracellular proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (STAT3-upregulated extracellular protein expression).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	83	R-HSA-8981073	Expression of Interleukin-10	yes	reactome/R-HSA-8981073.md	Expression of Interleukin-10	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (Expression of Interleukin-10).
human	IL10	genes/human/IL10/IL10-ai-review.yaml	IL10	P22301	NCBITaxon:9606	Homo sapiens	84	R-HSA-9664346	IL10 gene produces IL10 protein	yes	reactome/R-HSA-9664346.md	IL10 gene produces IL10 protein	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS for extracellular region from Reactome (IL10 gene produces IL10 protein).
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	59	R-HSA-449818	IL13 binds IL13RA2	yes	reactome/R-HSA-449818.md	IL13 binds IL13RA2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""IL13 binds IL13RA2."" IL-13 is in the extracellular region when it binds its decoy receptor."
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	60	R-HSA-6786050	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated	yes	reactome/R-HSA-6786050.md	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. IL-13 is extracellular in the context of receptor phosphorylation events.
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	61	R-HSA-6786110	JAK1 binds IL4R in IL13-bound IL13R type II	yes	reactome/R-HSA-6786110.md	JAK1 binds IL4R in IL13-bound IL13R type II	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""JAK1 binds IL4R in IL13-bound IL13R type II."""
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	62	R-HSA-6786114	IL13:IL13RA:TYK2 binds IL4R:JAK2	yes	reactome/R-HSA-6786114.md	IL13:IL13RA:TYK2 binds IL4R:JAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""IL13:IL13RA:TYK2 binds IL4R:JAK2."""
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	63	R-HSA-6786118	IL13 binds IL13RA:TYK2	yes	reactome/R-HSA-6786118.md	IL13 binds IL13RA:TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""IL13 binds IL13RA:TYK2."""
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	64	R-HSA-6788571	STAT1,STAT3,STAT6 bind IL13:IL13R type II	yes	reactome/R-HSA-6788571.md	STAT1,STAT3,STAT6 bind IL13:IL13R type II	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""STAT1,STAT3,STAT6 bind IL13:IL13R type II."""
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	65	R-HSA-6788582	STAT1,STAT3,STAT6 phosphorylation	yes	reactome/R-HSA-6788582.md	STAT1,STAT3,STAT6 phosphorylation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""STAT1,STAT3,STAT6 phosphorylation."""
human	IL13	genes/human/IL13/IL13-ai-review.yaml	IL13	P35225	NCBITaxon:9606	Homo sapiens	66	R-HSA-6788628	p-Y-STATs dissociate	yes	reactome/R-HSA-6788628.md	p-Y-STATs dissociate	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""p-Y-STATs dissociate."""
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	34	R-HSA-449115	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3	yes	reactome/R-HSA-449115.md	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway shows IL15:IL15RA complex formation. IL15 is found extracellularly.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	35	R-HSA-8983298	IL15 binds IL2RB:JAK1 and IL2RG:JAK3	yes	reactome/R-HSA-8983298.md	IL15 binds IL2RB:JAK1 and IL2RG:JAK3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step. Redundant but correct.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	36	R-HSA-8983300	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1	yes	reactome/R-HSA-8983300.md	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	37	R-HSA-8983307	IL15 binds IL15RA	yes	reactome/R-HSA-8983307.md	IL15 binds IL15RA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	38	R-HSA-8983335	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	yes	reactome/R-HSA-8983335.md	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step showing receptor complex translocation.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	39	R-HSA-8983371	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	yes	reactome/R-HSA-8983371.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	40	R-HSA-8983374	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	yes	reactome/R-HSA-8983374.md	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	41	R-HSA-8983378	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	yes	reactome/R-HSA-8983378.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	42	R-HSA-8983384	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	yes	reactome/R-HSA-8983384.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome pathway step.
human	IL15	genes/human/IL15/IL15-ai-review.yaml	IL15	P40933	NCBITaxon:9606	Homo sapiens	43	R-HSA-8983335	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	yes	reactome/R-HSA-8983335.md	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	Homo sapiens	GO:0005768	endosome	TAS	located_in	CC	false		ACCEPT	ACCEPT: Reactome shows IL15 receptor complex translocates to endosome during signaling.
human	IL21	genes/human/IL21/IL21-ai-review.yaml	IL21	Q9HBE4	NCBITaxon:9606	Homo sapiens	29	R-HSA-9005980	IL21 binds IL21R:JAK1	yes	reactome/R-HSA-9005980.md	IL21 binds IL21R:JAK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway reference for IL21 binding to IL21R. Confirms secreted nature of IL21. Duplicate with other extracellular region annotations.
human	IL21	genes/human/IL21/IL21-ai-review.yaml	IL21	Q9HBE4	NCBITaxon:9606	Homo sapiens	30	R-HSA-9006844	IL21:IL21R:JAK1 binds IL2RG:JAK3	yes	reactome/R-HSA-9006844.md	IL21:IL21R:JAK1 binds IL2RG:JAK3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway reference. Duplicate annotation.
human	IL21	genes/human/IL21/IL21-ai-review.yaml	IL21	Q9HBE4	NCBITaxon:9606	Homo sapiens	31	R-HSA-9006850	IL21 receptor JAK phosphorylation	yes	reactome/R-HSA-9006850.md	IL21 receptor JAK phosphorylation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway reference. Duplicate annotation.
human	IL21	genes/human/IL21/IL21-ai-review.yaml	IL21	Q9HBE4	NCBITaxon:9606	Homo sapiens	32	R-HSA-9006870	IL21 receptor STAT phosphorylation	yes	reactome/R-HSA-9006870.md	IL21 receptor STAT phosphorylation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway reference. Duplicate annotation.
human	IL21	genes/human/IL21/IL21-ai-review.yaml	IL21	Q9HBE4	NCBITaxon:9606	Homo sapiens	33	R-HSA-9006873	IL21 receptor STAT binding	yes	reactome/R-HSA-9006873.md	IL21 receptor STAT binding	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway reference. Duplicate annotation.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	13	R-HSA-448480	IL22 binds IL22RA1:JAK1 receptor complex	yes	reactome/R-HSA-448480.md	IL22 binds IL22RA1:JAK1 receptor complex	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct annotation from Reactome pathway showing IL-22 binding to IL-22RA1:JAK1 receptor complex in the extracellular space. Multiple Reactome annotations provide pathway-specific evidence.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	14	R-HSA-448741	IL22RA2 binds IL22	yes	reactome/R-HSA-448741.md	IL22RA2 binds IL22	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct annotation showing IL-22 binding to its soluble antagonist IL-22RA2 (IL-22BP) in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	15	R-HSA-8854645	IL22:IL22RA1:JAK1 binds IL10RB:TYK2	yes	reactome/R-HSA-8854645.md	IL22:IL22RA1:JAK1 binds IL10RB:TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Another correct Reactome annotation showing IL-22 receptor complex formation in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	16	R-HSA-8986995	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA	yes	reactome/R-HSA-8986995.md	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	17	R-HSA-8987014	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	yes	reactome/R-HSA-8987014.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	18	R-HSA-8987042	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	yes	reactome/R-HSA-8987042.md	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	19	R-HSA-8987070	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987070.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	20	R-HSA-8987132	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	yes	reactome/R-HSA-8987132.md	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL22	genes/human/IL22/IL22-ai-review.yaml	IL22	Q9GZX6	NCBITaxon:9606	Homo sapiens	21	R-HSA-8987236	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-8987236.md	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct Reactome annotation documenting IL-22 signaling pathway events in the extracellular region.
human	IL23R	genes/human/IL23R/IL23R-ai-review.yaml	IL23R	Q5VWK5	NCBITaxon:9606	Homo sapiens	32	R-HSA-8950269	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	yes	reactome/R-HSA-8950269.md	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the IL-23 signaling pathway model (STAT3/STAT4 phosphorylation step). IL23R is part of the plasma membrane receptor complex in IL-23 signaling.
human	IL23R	genes/human/IL23R/IL23R-ai-review.yaml	IL23R	Q5VWK5	NCBITaxon:9606	Homo sapiens	33	R-HSA-8952749	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	yes	reactome/R-HSA-8952749.md	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the STAT4 binding step in IL-23 signaling. Duplicate plasma membrane annotation from a different Reactome reaction.
human	IL23R	genes/human/IL23R/IL23R-ai-review.yaml	IL23R	Q5VWK5	NCBITaxon:9606	Homo sapiens	34	R-HSA-8952823	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	yes	reactome/R-HSA-8952823.md	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the STAT dissociation step in IL-23 signaling. Duplicate plasma membrane annotation from a different Reactome reaction.
human	IL23R	genes/human/IL23R/IL23R-ai-review.yaml	IL23R	Q5VWK5	NCBITaxon:9606	Homo sapiens	61	R-HSA-447130	Interleukin-23 binds interleukin-23 receptor	yes	reactome/R-HSA-447130.md	Interleukin-23 binds interleukin-23 receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the IL-23 binding reaction in the Reactome pathway model. IL23R is located at the plasma membrane.
human	IL23R	genes/human/IL23R/IL23R-ai-review.yaml	IL23R	Q5VWK5	NCBITaxon:9606	Homo sapiens	62	R-HSA-6790022	Expression of STAT3-upregulated plasma membrane proteins	yes	reactome/R-HSA-6790022.md	Expression of STAT3-upregulated plasma membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the STAT3-upregulated plasma membrane proteins pathway. IL23R is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	27	R-HSA-450027	Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta	yes	reactome/R-HSA-450027.md	Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome reaction R-HSA-450027 (IL2RA:IL2 binds IL2RB). IL2RA is at the plasma membrane during IL-2 receptor complex assembly.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	28	R-HSA-450054	Interleukin-2 receptor alpha binds interleukin-2	yes	reactome/R-HSA-450054.md	Interleukin-2 receptor alpha binds interleukin-2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome reaction R-HSA-450054 (IL2RA binds IL-2). IL2RA captures IL-2 at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	29	R-HSA-450063	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit	yes	reactome/R-HSA-450063.md	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome reaction R-HSA-450063 (IL2:IL2RA:IL2RB binds IL2RG). IL2RA is at the plasma membrane as the trimeric complex assembles.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	30	R-HSA-451942	Within the IL-2R complex JAK3 phosphorylates JAK1	yes	reactome/R-HSA-451942.md	Within the IL-2R complex JAK3 phosphorylates JAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome reaction R-HSA-451942 (JAK3 phosphorylates JAK1 within the IL-2R complex). IL2RA is a component of this complex at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	31	R-HSA-452091	Phosphorylation of IL2RB Y338 enables SHC recruitment	yes	reactome/R-HSA-452091.md	Phosphorylation of IL2RB Y338 enables SHC recruitment	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (IL2RB Y338 phosphorylation enables SHC recruitment). IL2RA is part of the receptor complex at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	32	R-HSA-452097	Recruited STAT5 is phosphorylated	yes	reactome/R-HSA-452097.md	Recruited STAT5 is phosphorylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (STAT5 phosphorylation at the IL-2 receptor complex). IL2RA is part of the complex at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	33	R-HSA-452100	SHC1 bound to IL2 receptor is phosphorylated	yes	reactome/R-HSA-452100.md	SHC1 bound to IL2 receptor is phosphorylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (SHC1 phosphorylation at the IL2 receptor). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	34	R-HSA-452108	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	yes	reactome/R-HSA-452108.md	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (IL2RB phosphorylation enables STAT recruitment). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	35	R-HSA-452122	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	yes	reactome/R-HSA-452122.md	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (JAK1 phosphorylates IL2RB). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	36	R-HSA-453104	Phosphorylated SHC1 recruits GRB2:GAB2	yes	reactome/R-HSA-453104.md	Phosphorylated SHC1 recruits GRB2:GAB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (phosphorylated SHC1 recruits GRB2:GAB2). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	37	R-HSA-453111	Phosphorylated SHC recruits GRB2:SOS1	yes	reactome/R-HSA-453111.md	Phosphorylated SHC recruits GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (phosphorylated SHC recruits GRB2:SOS1). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	38	R-HSA-508247	Gab2 binds the p85 subunit of Class 1A PI3 kinases	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (Gab2 binds p85 of PI3K). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	39	R-HSA-508282	SYK is a substrate for JAK1	yes	reactome/R-HSA-508282.md	SYK is a substrate for JAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (SYK is a substrate for JAK1). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	40	R-HSA-508292	SYK binds IL2RB	yes	reactome/R-HSA-508292.md	SYK binds IL2RB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (SYK binds IL2RB). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	41	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (RAS GEFs promote RAS nucleotide exchange). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	42	R-HSA-8877396	IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1	yes	reactome/R-HSA-8877396.md	IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (IL2RA gene expression regulation by FOXP3/RUNX1). This Reactome entry concerns transcriptional regulation of IL2RA itself, not its localization. The plasma membrane annotation is still correct for the IL2RA protein.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	43	R-HSA-912527	SHC1 mediates cytokine-induced phosphorylation of GAB2	yes	reactome/R-HSA-912527.md	SHC1 mediates cytokine-induced phosphorylation of GAB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (SHC1 mediates cytokine-induced GAB2 phosphorylation). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	44	R-HSA-913374	Phosphorylated SHC1 recruits SHIP	yes	reactome/R-HSA-913374.md	Phosphorylated SHC1 recruits SHIP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (phosphorylated SHC1 recruits SHIP). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	45	R-HSA-913424	The SHC1:SHIP1 complex is stabilized by GRB2	yes	reactome/R-HSA-913424.md	The SHC1:SHIP1 complex is stabilized by GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (SHC1:SHIP1 complex stabilized by GRB2). IL2RA is at the plasma membrane.
human	IL2RA	genes/human/IL2RA/IL2RA-ai-review.yaml	IL2RA	P01589	NCBITaxon:9606	Homo sapiens	46	R-HSA-919404	Phosphorylated STAT5 is released	yes	reactome/R-HSA-919404.md	Phosphorylated STAT5 is released	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (phosphorylated STAT5 is released). IL2RA is at the plasma membrane.
human	IL36RN	genes/human/IL36RN/IL36RN-ai-review.yaml	IL36RN	Q9UBH0	NCBITaxon:9606	Homo sapiens	22	R-HSA-8940998	IL36RN, IL1F10 bind IL1RL2	yes	reactome/R-HSA-8940998.md	IL36RN, IL1F10 bind IL1RL2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Traceable author statement for extracellular region from Reactome pathway.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	51	R-HSA-6785821	SOCS5,(SOCS1) bind IL4RA	yes	reactome/R-HSA-6785821.md	SOCS5,(SOCS1) bind IL4RA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for IL-4 participation in the IL-4/IL-13 signaling pathway, specifically the SOCS5/SOCS1 binding to IL4RA reaction. IL-4 is correctly placed in the extracellular region.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	52	R-HSA-6786058	JAK1 binds IL4R in IL4-bound IL4R1	yes	reactome/R-HSA-6786058.md	JAK1 binds IL4R in IL4-bound IL4R1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for IL-4 signaling - JAK1 binding to IL4R in IL4-bound complex.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	53	R-HSA-6786070	IL4:IL4R:JAK2 binds IL13RA1:TYK2	yes	reactome/R-HSA-6786070.md	IL4:IL4R:JAK2 binds IL13RA1:TYK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for type II receptor complex assembly (IL-4 complex binding IL13RA1/TYK2).
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	54	R-HSA-6786072	p-Y705-STAT3,p-Y641-STAT6 dissociate	yes	reactome/R-HSA-6786072.md	p-Y705-STAT3,p-Y641-STAT6 dissociate	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for STAT3/STAT6 dissociation step in IL-4 signaling.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	55	R-HSA-6786092	IL4:IL4R:JAK2 binds IL2RG:JAK3	yes	reactome/R-HSA-6786092.md	IL4:IL4R:JAK2 binds IL2RG:JAK3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for type I receptor complex assembly (IL-4 complex binding IL2RG/JAK3).
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	56	R-HSA-6786095	JAK1 phosphorylates STAT3,STAT6	yes	reactome/R-HSA-6786095.md	JAK1 phosphorylates STAT3,STAT6	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for JAK1 phosphorylation of STAT3/STAT6 in IL-4 signaling.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	57	R-HSA-6786096	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	yes	reactome/R-HSA-6786096.md	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for phosphorylation of IL4R/IL2RG/JAK1 components.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	58	R-HSA-6786101	IL4 binds IL4R:JAK2	yes	reactome/R-HSA-6786101.md	IL4 binds IL4R:JAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for IL-4 binding to IL4R/JAK2.
human	IL4	genes/human/IL4/IL4-ai-review.yaml	IL4	P05112	NCBITaxon:9606	Homo sapiens	59	R-HSA-6786124	STAT3,STAT6 bind p-Y-IL4R	yes	reactome/R-HSA-6786124.md	STAT3,STAT6 bind p-Y-IL4R	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for STAT3/STAT6 binding to phosphorylated IL4R.
human	IL4I1	genes/human/IL4I1/IL4I1-ai-review.yaml	IL4I1	Q96RQ9	NCBITaxon:9606	Homo sapiens	42	R-HSA-2160492	IL4I1:FAD oxidises L-Phe to kPPV	yes	reactome/R-HSA-2160492.md	IL4I1:FAD oxidises L-Phe to kPPV	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome pathway annotation for ""IL4I1:FAD oxidises L-Phe to kPPV"" indicates extracellular localization for the reaction. This is consistent with IL4I1 being a secreted enzyme."
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	24	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	IL7R annotated to clathrin-coated endocytic vesicle membrane from Reactome clathrin-mediated endocytosis pathway. Cytokine receptors including IL7R undergo clathrin-mediated endocytosis as part of receptor internalization and signal attenuation. IL7R is ubiquitinated by MARCHF8, leading to lysosomal degradation (PMID:39311660), which is consistent with endocytic trafficking.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	25	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from a different reaction in the endocytosis pathway.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	26	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from endocytosis pathway.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	27	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from dynamin-mediated vesicle scission step.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	28	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from clathrin-associated protein dissociation step.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	29	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from AAK1 dissociation step.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	30	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome annotation for clathrin-coated endocytic vesicle membrane from RAB5 binding step.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	34	R-HSA-449958	IL7:IL7R:JAK1 binds IL2RG:JAK3	yes	reactome/R-HSA-449958.md	IL7:IL7R:JAK1 binds IL2RG:JAK3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome IL-7 signaling pathway step where IL7:IL7R:JAK1 binds IL2RG:JAK3 to form the signaling complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	35	R-HSA-449978	IL7 binds IL7R:JAK1	yes	reactome/R-HSA-449978.md	IL7 binds IL7R:JAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where IL7 binds IL7R:JAK1.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	36	R-HSA-8866277	AP-2 directly binds some endocytic cargo	yes	reactome/R-HSA-8866277.md	AP-2 directly binds some endocytic cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway step where AP-2 binds endocytic cargo at the plasma membrane.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	37	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	38	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (CLASP recruitment step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	39	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (clathrin recruits PIK3C2A step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	40	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (PIK3C2A phosphorylation step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	41	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (SNX9 recruitment step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	42	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (dynamin recruitment step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	43	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (synaptojanin step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	44	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (endophilin step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	45	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome endocytosis pathway (dynamin GTP hydrolysis step).
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	46	R-HSA-8983059	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex	yes	reactome/R-HSA-8983059.md	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome TSLP signaling pathway where STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	47	R-HSA-8983061	TSLP binds CRLF2:IL7R	yes	reactome/R-HSA-8983061.md	TSLP binds CRLF2:IL7R	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where TSLP binds CRLF2:IL7R.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	48	R-HSA-8983063	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated	yes	reactome/R-HSA-8983063.md	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome IL-7 signaling where JAK3 is phosphorylated in the IL7:IL7R:JAK1:IL2RG:JAK3 complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	49	R-HSA-8983078	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex	yes	reactome/R-HSA-8983078.md	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where p-STAT3 dissociates from TSLP:IL7R:CRLF2 complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	50	R-NUL-8982998	Stat3 binds IL7R:TSLP:CRLF2	yes	reactome/R-NUL-8982998.md	Stat3 binds IL7R:TSLP:CRLF2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where Stat3 binds IL7R:TSLP:CRLF2 complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	51	R-HSA-1295540	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	yes	reactome/R-HSA-1295540.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where the IL7:IL7R:JAK1:IL2RG: JAK3 complex phosphorylates STAT5.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	52	R-HSA-6785165	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	yes	reactome/R-HSA-6785165.md	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where p-STAT5A/B dissociates from the IL-7 signaling complex.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	53	R-HSA-8983003	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2	yes	reactome/R-HSA-8983003.md	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where the IL-7 receptor complex binds PI3K regulatory subunits and IRS1/IRS2.
human	IL7R	genes/human/IL7R/IL7R-ai-review.yaml	IL7R	P16871	NCBITaxon:9606	Homo sapiens	54	R-HSA-9025969	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	yes	reactome/R-HSA-9025969.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	IL7R at plasma membrane from Reactome where STAT5 binds the activated IL-7 receptor complex.
human	ILF3	genes/human/ILF3/ILF3-ai-review.yaml	ILF3	Q12906	NCBITaxon:9606	Homo sapiens	25	R-HSA-9834807	ILF3 binds PKR	yes	reactome/R-HSA-9834807.md	ILF3 binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is supported as a non-core ILF3 localization.
human	ILF3	genes/human/ILF3/ILF3-ai-review.yaml	ILF3	Q12906	NCBITaxon:9606	Homo sapiens	26	R-HSA-9836383	p-PKR dimer phosphorylates ILF3:ILF2	yes	reactome/R-HSA-9836383.md	p-PKR dimer phosphorylates ILF3:ILF2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is supported as a non-core ILF3 localization.
human	ILF3	genes/human/ILF3/ILF3-ai-review.yaml	ILF3	Q12906	NCBITaxon:9606	Homo sapiens	27	R-HSA-9760399	ILF3 and HOXC8 bind CDH11 gene promoter	yes	reactome/R-HSA-9760399.md	ILF3 and HOXC8 bind CDH11 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a core ILF3 localization context.
human	ILF3	genes/human/ILF3/ILF3-ai-review.yaml	ILF3	Q12906	NCBITaxon:9606	Homo sapiens	28	R-HSA-9760402	ILF3 binds HOXC8	yes	reactome/R-HSA-9760402.md	ILF3 binds HOXC8	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a core ILF3 localization context.
human	ILF3	genes/human/ILF3/ILF3-ai-review.yaml	ILF3	Q12906	NCBITaxon:9606	Homo sapiens	29	R-HSA-9760652	ILF3 binds CDH11 gene promoter	yes	reactome/R-HSA-9760652.md	ILF3 binds CDH11 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is a core ILF3 localization context.
human	ILK	genes/human/ILK/ILK-ai-review.yaml	ILK	Q13418	NCBITaxon:9606	Homo sapiens	85	R-HSA-432897	Reactome pathway	yes	reactome/R-HSA-432897.md	ILK interacts with beta-1 integrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for ILK.
human	ILK	genes/human/ILK/ILK-ai-review.yaml	ILK	Q13418	NCBITaxon:9606	Homo sapiens	86	R-HSA-446391	Reactome pathway	yes	reactome/R-HSA-446391.md	Formation of the PINCH-ILK-parvin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: a core subcellular location for ILK.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	15	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular localization inferred from a Reactome neutrophil-degranulation exocytosis event (secretory granule proteins), not from a dedicated function of IMPDH1.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	16	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Duplicate extracellular-region localization from a Reactome azurophil-granule exocytosis event.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	17	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Duplicate extracellular-region localization from a Reactome ficolin-rich granule exocytosis event.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Secretory granule lumen localization from the Reactome neutrophil-degranulation pathway.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Azurophil granule lumen localization from the Reactome neutrophil-degranulation pathway.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	20	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Ficolin-1-rich granule lumen localization from the Reactome neutrophil-degranulation pathway.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	21	R-HSA-73794	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]	yes	reactome/R-HSA-73794.md	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by the Reactome IMP -> XMP reaction, the core catalytic event of IMPDH1.
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	22	R-HSA-9678749	IMPDH tetramers bind IMPDH inhibitors	yes	reactome/R-HSA-9678749.md	IMPDH tetramers bind IMPDH inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic localization from the Reactome ""IMPDH tetramers bind IMPDH inhibitors"" reaction (drug-binding context)."
human	IMPDH1	genes/human/IMPDH1/IMPDH1-ai-review.yaml	IMPDH1	P20839	NCBITaxon:9606	Homo sapiens	23	R-HSA-9748945	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP	yes	reactome/R-HSA-9748945.md	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic localization from the Reactome ""IMPDH tetramers dehydrogenate 6TIMP to 6TXMP"" reaction (thiopurine metabolism context)."
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	25	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome pathway-membership annotation placing IMPDH2 in exocytosis of secretory granule lumen proteins (neutrophil degranulation), yielding an extracellular-region location.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	26	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome pathway-membership annotation (exocytosis of ficolin-rich granule lumen proteins) placing IMPDH2 in the extracellular region.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation pathway-membership annotation to secretory granule lumen.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	28	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation pathway-membership annotation to ficolin-1-rich granule lumen.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	31	R-HSA-73794	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]	yes	reactome/R-HSA-73794.md	IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for the IMP + H2O + NAD+ to XMP + NADH + H+ reaction placing the IMPDH1,2 activity in the cytosol.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	32	R-HSA-9678749	IMPDH tetramers bind IMPDH inhibitors	yes	reactome/R-HSA-9678749.md	IMPDH tetramers bind IMPDH inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation (IMPDH tetramers bind IMPDH inhibitors) placing IMPDH2 in the cytosol.
human	IMPDH2	genes/human/IMPDH2/IMPDH2-ai-review.yaml	IMPDH2	P12268	NCBITaxon:9606	Homo sapiens	33	R-HSA-9748945	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP	yes	reactome/R-HSA-9748945.md	IMPDH tetramers dehydrogenate 6TIMP to 6TXMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation (IMPDH tetramers dehydrogenate 6TIMP to 6TXMP, thiopurine metabolism) placing IMPDH2 in the cytosol.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	26	R-HSA-1660499	Synthesis of PIPs at the plasma membrane	yes	reactome/R-HSA-1660499.md	Synthesis of PIPs at the plasma membrane	Homo sapiens	GO:0006661	phosphatidylinositol biosynthetic process	TAS	involved_in	BP	false		MODIFY	Reactome captures PIP pathway chemistry, but biosynthetic process is the wrong direction for INPP5D.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	27	R-HSA-202403	TCR signaling	yes	reactome/R-HSA-202403.md	TCR signaling	Homo sapiens	GO:0050852	T cell receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	This immune differentiation or effector outcome is plausible for SHIP1 signaling but is downstream of the core PIP3/IP4 phosphatase mechanism.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	28	R-HSA-202237	Hydrolysis of PIP3 to PI(3,4)P2	yes	reactome/R-HSA-202237.md	Hydrolysis of PIP3 to PI(3,4)P2	Homo sapiens	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	TAS	enables	MF	false		MODIFY	INPP5D hydrolyzes the 5-phosphate of PtdIns(3,4,5)P3, not the 3-phosphate.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	29	R-HSA-1675949	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane	yes	reactome/R-HSA-1675949.md	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane	Homo sapiens	GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	TAS	enables	MF	false		ACCEPT	SHIP1/INPP5D is a hematopoietic inositol/phosphatidylinositol 5-phosphatase, with core activity toward PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	48	R-HSA-1675949	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane	yes	reactome/R-HSA-1675949.md	PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SHIP1 is cytosolic and recruited to membranes, membrane rafts, and cytoskeletal/plasma-membrane signaling sites after immune-receptor activation.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	49	R-HSA-1855218	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol	yes	reactome/R-HSA-1855218.md	I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SHIP1 is cytosolic and recruited to membranes, membrane rafts, and cytoskeletal/plasma-membrane signaling sites after immune-receptor activation.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	50	R-HSA-202237	Hydrolysis of PIP3 to PI(3,4)P2	yes	reactome/R-HSA-202237.md	Hydrolysis of PIP3 to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SHIP1 is cytosolic and recruited to membranes, membrane rafts, and cytoskeletal/plasma-membrane signaling sites after immune-receptor activation.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	51	R-HSA-210290	Interaction of PECAM-1 and SHIP	yes	reactome/R-HSA-210290.md	Interaction of PECAM-1 and SHIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SHIP1 is cytosolic and recruited to membranes, membrane rafts, and cytoskeletal/plasma-membrane signaling sites after immune-receptor activation.
human	INPP5D	genes/human/INPP5D/INPP5D-ai-review.yaml	INPP5D	Q92835	NCBITaxon:9606	Homo sapiens	52	R-HSA-913374	Phosphorylated SHC1 recruits SHIP	yes	reactome/R-HSA-913374.md	Phosphorylated SHC1 recruits SHIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SHIP1 is cytosolic and recruited to membranes, membrane rafts, and cytoskeletal/plasma-membrane signaling sites after immune-receptor activation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	35	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Proinsulin passes through the Golgi apparatus during its trafficking from ER to secretory granules.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	36	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Golgi membrane annotation from different Reactome reaction.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	37	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Another Golgi membrane annotation from Reactome.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	38	R-HSA-264997	P4HB mediates disulfide bond formation in Proinsulin	yes	reactome/R-HSA-264997.md	P4HB mediates disulfide bond formation in Proinsulin	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Proinsulin enters the ER lumen after translocation and undergoes disulfide bond formation there.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	39	R-HSA-265010	Proinsulin translocates from the endoplasmic reticulum to the Golgi	yes	reactome/R-HSA-265010.md	Proinsulin translocates from the endoplasmic reticulum to the Golgi	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Another ER lumen annotation from Reactome pathway.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	40	R-HSA-264976	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium	yes	reactome/R-HSA-264976.md	Proinsulin binds zinc and calcium forming Proinsulin:zinc:calcium	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	Proinsulin travels through the Golgi lumen and binds zinc and calcium there.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	41	R-HSA-265010	Proinsulin translocates from the endoplasmic reticulum to the Golgi	yes	reactome/R-HSA-265010.md	Proinsulin translocates from the endoplasmic reticulum to the Golgi	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	Duplicate Golgi lumen annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	42	R-HSA-265153	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule	yes	reactome/R-HSA-265153.md	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		ACCEPT	Another Golgi lumen annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	43	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Proinsulin travels in transport vesicles from ER to Golgi and from Golgi to secretory granules.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	44	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Duplicate transport vesicle annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	45	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Another transport vesicle annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	46	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	The ERGIC is an intermediate compartment between ER and Golgi that proinsulin passes through.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	47	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Duplicate ERGIC annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	48	R-HSA-265153	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule	yes	reactome/R-HSA-265153.md	Proinsulin:Zinc:Calcium complex translocates to immature secretory granule	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Proinsulin is packaged into secretory granules where it is processed to mature insulin and stored as zinc-insulin crystals.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	49	R-NUL-9023165	Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)	yes	reactome/R-NUL-9023165.md	Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Annotation for proinsulin processing in secretory granules (rat PC1/3 cleaves human proinsulin).
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	50	R-NUL-9023166	Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)	yes	reactome/R-NUL-9023166.md	Carboxypeptidase E (rat Carboxypeptidase H) cleaves Insulin(25-56) to yield Insulin(25-54)	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Another secretory granule annotation for processing steps.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	51	R-NUL-9023180	Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))	yes	reactome/R-NUL-9023180.md	Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Secretory granule annotation for PC2-mediated cleavage step.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	52	R-NUL-9023186	Carboxypeptidase E (rat Carboxypeptidase H) cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))	yes	reactome/R-NUL-9023186.md	Carboxypeptidase E (rat Carboxypeptidase H) cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Secretory granule annotation for carboxypeptidase processing.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	60	R-HSA-110011	Binding of Grb10 to the insulin receptor	yes	reactome/R-HSA-110011.md	Binding of Grb10 to the insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Multiple Reactome pathways document insulin in extracellular region during receptor binding and signaling.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	61	R-HSA-74707	Binding of IRS to insulin receptor	yes	reactome/R-HSA-74707.md	Binding of IRS to insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for insulin binding to insulin receptor.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	62	R-HSA-74711	Phosphorylation of IRS	yes	reactome/R-HSA-74711.md	Phosphorylation of IRS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for extracellular region.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	63	R-HSA-74712	Dissociation of IRS-P from insulin receptor	yes	reactome/R-HSA-74712.md	Dissociation of IRS-P from insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	64	R-HSA-74715	Autophosphorylation of insulin receptor	yes	reactome/R-HSA-74715.md	Autophosphorylation of insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	65	R-HSA-74716	Insulin binds the insulin receptor	yes	reactome/R-HSA-74716.md	Insulin binds the insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	66	R-HSA-74718	Internalisation of the insulin receptor	yes	reactome/R-HSA-74718.md	Internalisation of the insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	67	R-HSA-74740	Binding of SHC1 to insulin receptor	yes	reactome/R-HSA-74740.md	Binding of SHC1 to insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	68	R-HSA-74742	Phosphorylation of SHC1	yes	reactome/R-HSA-74742.md	Phosphorylation of SHC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	69	R-HSA-74743	Dissociation of p-Y427-SHC1 from insulin receptor	yes	reactome/R-HSA-74743.md	Dissociation of p-Y427-SHC1 from insulin receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	70	R-HSA-976734	Amyloid fibrils have additional components	yes	reactome/R-HSA-976734.md	Amyloid fibrils have additional components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	71	R-HSA-977136	Amyloid precursor proteins form ordered fibrils	yes	reactome/R-HSA-977136.md	Amyloid precursor proteins form ordered fibrils	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	88	R-HSA-74718	Internalisation of the insulin receptor	yes	reactome/R-HSA-74718.md	Internalisation of the insulin receptor	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	After internalization of the insulin-insulin receptor complex, insulin traffics through endosomes where it can be degraded or the receptor recycled.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	89	R-HSA-74726	Dissociation of insulin from insulin receptor	yes	reactome/R-HSA-74726.md	Dissociation of insulin from insulin receptor	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	Reactome pathway for insulin in endosomes.
human	INS	genes/human/INS/INS-ai-review.yaml	INS	P01308	NCBITaxon:9606	Homo sapiens	90	R-HSA-74730	Insulin degradation	yes	reactome/R-HSA-74730.md	Insulin degradation	Homo sapiens	GO:0031904	endosome lumen	TAS	located_in	CC	false		ACCEPT	Reactome pathway for insulin degradation in endosomes.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	23	R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	yes	reactome/R-HSA-1855167.md	Synthesis of pyrophosphates in the cytosol	Homo sapiens	GO:0043647	inositol phosphate metabolic process	TAS	involved_in	BP	false		ACCEPT	inositol phosphate metabolic process is supported because IP6K3 biosynthesizes/metabolizes soluble inositol pyrophosphates from inositol phosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	24	R-HSA-1855227	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855227.md	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol	Homo sapiens	GO:0000828	inositol hexakisphosphate kinase activity	TAS	enables	MF	false		ACCEPT	inositol hexakisphosphate kinase activity fits the characterized IP6K3 catalytic activity toward soluble inositol polyphosphate and inositol pyrophosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	25	R-HSA-1855194	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855194.md	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol	Homo sapiens	GO:0000829	diphosphoinositol pentakisphosphate kinase activity	TAS	enables	MF	false		ACCEPT	diphosphoinositol pentakisphosphate kinase activity fits the characterized IP6K3 catalytic activity toward soluble inositol polyphosphate and inositol pyrophosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	26	R-HSA-1855158	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855158.md	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol	Homo sapiens	GO:0052836	inositol 5-diphosphate pentakisphosphate 5-kinase activity	TAS	enables	MF	false		ACCEPT	inositol 5-diphosphate pentakisphosphate 5-kinase activity fits the characterized IP6K3 catalytic activity toward soluble inositol polyphosphate and inositol pyrophosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	27	R-HSA-1855193	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855193.md	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol	Homo sapiens	GO:0052839	diphosphoinositol tetrakisphosphate kinase activity	TAS	enables	MF	false		ACCEPT	diphosphoinositol tetrakisphosphate kinase activity fits the characterized IP6K3 catalytic activity toward soluble inositol polyphosphate and inositol pyrophosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	28	R-HSA-1855223	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855223.md	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol	Homo sapiens	GO:0000827	inositol-1,3,4,5,6-pentakisphosphate kinase activity	TAS	enables	MF	false		ACCEPT	inositol-1,3,4,5,6-pentakisphosphate kinase activity fits the characterized IP6K3 catalytic activity toward soluble inositol polyphosphate and inositol pyrophosphate substrates.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	30	R-HSA-1855158	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855158.md	5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported by the original characterization, which reported IP6K3 as predominantly cytoplasmic.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	31	R-HSA-1855193	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855193.md	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported by the original characterization, which reported IP6K3 as predominantly cytoplasmic.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	32	R-HSA-1855194	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855194.md	1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported by the original characterization, which reported IP6K3 as predominantly cytoplasmic.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	33	R-HSA-1855223	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855223.md	I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported by the original characterization, which reported IP6K3 as predominantly cytoplasmic.
human	IP6K3	genes/human/IP6K3/IP6K3-ai-review.yaml	IP6K3	Q96PC2	NCBITaxon:9606	Homo sapiens	34	R-HSA-1855227	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol	yes	reactome/R-HSA-1855227.md	IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported by the original characterization, which reported IP6K3 as predominantly cytoplasmic.
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	31	R-HSA-9907145	IRF4 binds the TYR promoter	yes	reactome/R-HSA-9907145.md	IRF4 binds the TYR promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9907145 (IRF4 binds the TYR promoter), placing IRF4 in the nucleoplasm where it binds the tyrosinase promoter in cooperation with MITF.
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	32	R-HSA-9907147	MITF-M-dependent IRF4 gene expression	yes	reactome/R-HSA-9907147.md	MITF-M-dependent IRF4 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9907147 (MITF-M-dependent IRF4 gene expression), placing IRF4 in the nucleoplasm.
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	42	R-HSA-1015702	Expression of IFN-induced genes	yes	reactome/R-HSA-1015702.md	Expression of IFN-induced genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-1015702 (Expression of IFN-induced genes), placing IRF4 in the cytosol. This represents a Reactome model where IRF4 is produced in the cytosol before translocation to the nucleus.
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	43	R-HSA-1031716	Expression of IFNG-stimulated genes	yes	reactome/R-HSA-1031716.md	Expression of IFNG-stimulated genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-1031716 (Expression of IFNG-stimulated genes).
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	44	R-HSA-6790041	Expression of STAT3-upregulated cytosolic proteins	yes	reactome/R-HSA-6790041.md	Expression of STAT3-upregulated cytosolic proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6790041 (Expression of STAT3-upregulated cytosolic proteins).
human	IRF4	genes/human/IRF4/IRF4-ai-review.yaml	IRF4	Q15306	NCBITaxon:9606	Homo sapiens	45	R-HSA-9851117	NPM1-ALK- and p-STAT3-dependent IRF4 gene expression	yes	reactome/R-HSA-9851117.md	NPM1-ALK- and p-STAT3-dependent IRF4 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9851117 (NPM1-ALK- and p-STAT3-dependent IRF4 gene expression).
human	IRF8	genes/human/IRF8/IRF8-ai-review.yaml	IRF8	Q02556	NCBITaxon:9606	Homo sapiens	44	R-HSA-1015702	Expression of IFN-induced genes	yes	reactome/R-HSA-1015702.md	Expression of IFN-induced genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for expression of IFN-induced genes. IRF8 is present in cytosol in unstimulated cells.
human	IRF8	genes/human/IRF8/IRF8-ai-review.yaml	IRF8	Q02556	NCBITaxon:9606	Homo sapiens	45	R-HSA-1031716	Expression of IFNG-stimulated genes	yes	reactome/R-HSA-1031716.md	Expression of IFNG-stimulated genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for expression of IFNG-stimulated genes.
human	ISCA1	genes/human/ISCA1/ISCA1-ai-review.yaml	ISCA1	Q9BUE6	NCBITaxon:9606	Homo sapiens	17	R-HSA-8878815	Formation of 4Fe-4S cluster on ISCA1:ISCA2	yes	reactome/R-HSA-8878815.md	Formation of 4Fe-4S cluster on ISCA1:ISCA2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Formation of 4Fe-4S cluster on ISCA1:ISCA2"". Specifies mitochondrial matrix localization."
human	ISCA1	genes/human/ISCA1/ISCA1-ai-review.yaml	ISCA1	Q9BUE6	NCBITaxon:9606	Homo sapiens	18	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Transfer of Fe-S clusters to SDHB"". Documents ISCA1's role in delivering [4Fe-4S] clusters to target proteins."
human	ISCA2	genes/human/ISCA2/ISCA2-ai-review.yaml	ISCA2	Q86U28	NCBITaxon:9606	Homo sapiens	27	R-HSA-8878815	Formation of 4Fe-4S cluster on ISCA1:ISCA2	yes	reactome/R-HSA-8878815.md	Formation of 4Fe-4S cluster on ISCA1:ISCA2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation indicating ISCA2 functions in the mitochondrial matrix, where [4Fe-4S] cluster formation occurs on the ISCA1:ISCA2 complex.
human	ISCA2	genes/human/ISCA2/ISCA2-ai-review.yaml	ISCA2	Q86U28	NCBITaxon:9606	Homo sapiens	28	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation for mitochondrial matrix localization in context of Fe-S cluster transfer to SDHB.
human	ISCU	genes/human/ISCU/ISCU-ai-review.yaml	ISCU	Q9H1K1	NCBITaxon:9606	Homo sapiens	48	R-HSA-9771686	nsp12 acquires Fe-S cluster cofactors	yes	reactome/R-HSA-9771686.md	nsp12 acquires Fe-S cluster cofactors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for cytosolic localization, related to SARS-CoV-2 nsp12 Fe-S cluster acquisition pathway.
human	ISCU	genes/human/ISCU/ISCU-ai-review.yaml	ISCU	Q9H1K1	NCBITaxon:9606	Homo sapiens	53	R-HSA-1362408	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	yes	reactome/R-HSA-1362408.md	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for mitochondrial matrix localization. Reactome pathway: FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster.
human	ISCU	genes/human/ISCU/ISCU-ai-review.yaml	ISCU	Q9H1K1	NCBITaxon:9606	Homo sapiens	54	R-HSA-1362416	Frataxin binds iron	yes	reactome/R-HSA-1362416.md	Frataxin binds iron	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for mitochondrial matrix. Reactome pathway: Frataxin binds iron.
human	ISCU	genes/human/ISCU/ISCU-ai-review.yaml	ISCU	Q9H1K1	NCBITaxon:9606	Homo sapiens	55	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for mitochondrial matrix. Reactome pathway: Transfer of Fe-S clusters to SDHB.
human	ISCU	genes/human/ISCU/ISCU-ai-review.yaml	ISCU	Q9H1K1	NCBITaxon:9606	Homo sapiens	56	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for mitochondrial matrix. Reactome pathway: 2Fe-2S is inserted in UQCRFS1.
human	ITIH2	genes/human/ITIH2/ITIH2-ai-review.yaml	ITIH2	P19823	NCBITaxon:9606	Homo sapiens	11	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		REMOVE	This TAS annotation is based on Reactome pathway annotation for FAM20C phosphorylation of substrates. While ITIH2 is phosphorylated by FAM20C, this kinase is an extracellular kinase, not an ER-localized one.
human	ITIH3	genes/human/ITIH3/ITIH3-ai-review.yaml	ITIH3	Q06033	NCBITaxon:9606	Homo sapiens	5	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places Q06033/ITIH3 in a platelet dense-granule-content set that is released extracellularly during exocytosis.
human	ITIH3	genes/human/ITIH3/ITIH3-ai-review.yaml	ITIH3	Q06033	NCBITaxon:9606	Homo sapiens	6	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0031089	platelet dense granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The current Reactome participant set explicitly includes Q06033/ITIH3 in the defined platelet dense-granule-content set.
human	ITIH4	genes/human/ITIH4/ITIH4-ai-review.yaml	ITIH4	Q14624	NCBITaxon:9606	Homo sapiens	6	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome models release of the ITIH4 70-kDa chain from platelet dense granules into the extracellular region.
human	ITIH4	genes/human/ITIH4/ITIH4-ai-review.yaml	ITIH4	Q14624	NCBITaxon:9606	Homo sapiens	7	R-HSA-481009	Exocytosis of platelet dense granule content	yes	reactome/R-HSA-481009.md	Exocytosis of platelet dense granule content	Homo sapiens	GO:0031089	platelet dense granule lumen	TAS	located_in	CC	false		UNDECIDED	Reactome explicitly places residues 29-661 of ITIH4 in its platelet dense-granule-content input set.
human	IVD	genes/human/IVD/IVD-ai-review.yaml	IVD	P26440	NCBITaxon:9606	Homo sapiens	14	R-HSA-9914837	IVD mutants don't synthesize beta-methylcrotonyl-CoA	no				GO:0008470	3-methylbutanoyl-CoA dehydrogenase activity	TAS	enables	MF	false		ACCEPT	Isovaleryl-CoA dehydrogenase activity, from a Reactome pathway describing IVD mutants failing to synthesize beta-methylcrotonyl-CoA. Captures the core catalytic function.
human	IVD	genes/human/IVD/IVD-ai-review.yaml	IVD	P26440	NCBITaxon:9606	Homo sapiens	17	R-HSA-70745	isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome for the isovaleryl-CoA dehydrogenation reaction. Correct compartment.
human	IVD	genes/human/IVD/IVD-ai-review.yaml	IVD	P26440	NCBITaxon:9606	Homo sapiens	18	R-HSA-9914837	IVD mutants don't synthesize beta-methylcrotonyl-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Mitochondrial matrix localization asserted by Reactome (isovaleric acidemia pathway). Correct compartment for IVD.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	49	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling	yes	reactome/R-HSA-6785807.md	Interleukin-4 and Interleukin-13 signaling	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	Duplicate annotation from Reactome
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	50	R-HSA-1112602	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	yes	reactome/R-HSA-1112602.md	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	Homo sapiens	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Duplicate Reactome annotation - IL6 receptor signaling
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	51	R-HSA-1112703	PTPN11 is phosphorylated	yes	reactome/R-HSA-1112703.md	PTPN11 is phosphorylated	Homo sapiens	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Duplicate Reactome annotation - PTPN11 phosphorylation
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	52	R-HSA-6786095	JAK1 phosphorylates STAT3,STAT6	yes	reactome/R-HSA-6786095.md	JAK1 phosphorylates STAT3,STAT6	Homo sapiens	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Duplicate Reactome annotation - STAT3/STAT6 phosphorylation
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	53	R-HSA-6786096	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	yes	reactome/R-HSA-6786096.md	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	Homo sapiens	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Duplicate Reactome annotation - IL4R phosphorylation
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	57	R-HSA-452122	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	yes	reactome/R-HSA-452122.md	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation - IL2RB phosphorylation
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	58	R-HSA-873924	Phosphorylation of IFNGR1 by JAK kinases	yes	reactome/R-HSA-873924.md	Phosphorylation of IFNGR1 by JAK kinases	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation - IFNGR1 phosphorylation
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	105	R-HSA-9020558	Interleukin-2 signaling	yes	reactome/R-HSA-9020558.md	Interleukin-2 signaling	Homo sapiens	GO:0038110	interleukin-2-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	IL-2 signals through the IL-2 receptor complex where JAK1 (associated with IL2RB) partners with JAK3 (associated with the common gamma chain) to phosphorylate the receptor and STAT5. Core gamma-c cytokine pathway for JAK1.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	106	R-HSA-877300	Interferon gamma signaling	yes	reactome/R-HSA-877300.md	Interferon gamma signaling	Homo sapiens	GO:0060333	type II interferon-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	Type II interferon (IFN-gamma) signaling requires JAK1 paired with JAK2 at the IFNGR complex to phosphorylate STAT1. Core cytokine pathway for JAK1 (Reactome Interferon gamma signaling).
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	107	R-HSA-909733	Interferon alpha/beta signaling	yes	reactome/R-HSA-909733.md	Interferon alpha/beta signaling	Homo sapiens	GO:0060337	type I interferon-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	Type I interferon (IFN-alpha/beta) signaling requires JAK1 (at IFNAR2) paired with TYK2 (at IFNAR1) to cross-phosphorylate and activate STAT1/STAT2. Core cytokine pathway for JAK1 (Reactome Interferon alpha/beta signaling).
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	108	R-HSA-1059683	Interleukin-6 signaling	yes	reactome/R-HSA-1059683.md	Interleukin-6 signaling	Homo sapiens	GO:0070102	interleukin-6-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	Core IL-6 family cytokine pathway mediated by JAK1 via gp130 receptor
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	113	R-HSA-8986994	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2	yes	reactome/R-HSA-8986994.md	IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	114	R-HSA-8987080	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	yes	reactome/R-HSA-8987080.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	115	R-HSA-8987097	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	yes	reactome/R-HSA-8987097.md	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	116	R-HSA-8987129	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated	yes	reactome/R-HSA-8987129.md	JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	117	R-HSA-8987150	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	yes	reactome/R-HSA-8987150.md	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	118	R-HSA-8987230	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	yes	reactome/R-HSA-8987230.md	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	119	R-HSA-8987255	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	yes	reactome/R-HSA-8987255.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	120	R-HSA-8987270	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	yes	reactome/R-HSA-8987270.md	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	142	R-HSA-8950340	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation	yes	reactome/R-HSA-8950340.md	IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	143	R-HSA-8950405	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated	yes	reactome/R-HSA-8950405.md	JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	144	R-HSA-8950441	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	yes	reactome/R-HSA-8950441.md	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	145	R-HSA-8950453	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	yes	reactome/R-HSA-8950453.md	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	146	R-HSA-8950485	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	yes	reactome/R-HSA-8950485.md	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	147	R-HSA-8950518	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	yes	reactome/R-HSA-8950518.md	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	148	R-HSA-8950537	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated	yes	reactome/R-HSA-8950537.md	JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	149	R-HSA-8982162	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB	yes	reactome/R-HSA-8982162.md	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	150	R-HSA-8982163	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8982163.md	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	151	R-HSA-8982165	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3	yes	reactome/R-HSA-8982165.md	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	152	R-HSA-8983300	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1	yes	reactome/R-HSA-8983300.md	IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	153	R-HSA-8983834	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated	yes	reactome/R-HSA-8983834.md	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	154	R-HSA-8983835	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1	yes	reactome/R-HSA-8983835.md	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	155	R-HSA-8983841	STAT1 associates with IL6ST:IL6ST	yes	reactome/R-HSA-8983841.md	STAT1 associates with IL6ST:IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	156	R-HSA-8983845	p-STAT1 dissociates from IL6ST:IL6ST	yes	reactome/R-HSA-8983845.md	p-STAT1 dissociates from IL6ST:IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	157	R-HSA-8983983	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983983.md	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	158	R-HSA-8983996	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983996.md	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	159	R-HSA-8984012	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated	yes	reactome/R-HSA-8984012.md	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	160	R-HSA-8984014	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	yes	reactome/R-HSA-8984014.md	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	161	R-HSA-8984021	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984021.md	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	162	R-HSA-8984023	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984023.md	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	163	R-HSA-8986985	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	yes	reactome/R-HSA-8986985.md	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	164	R-HSA-8986995	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA	yes	reactome/R-HSA-8986995.md	IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	165	R-HSA-8987012	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1	yes	reactome/R-HSA-8987012.md	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	166	R-HSA-8987014	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	yes	reactome/R-HSA-8987014.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	167	R-HSA-8987033	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	yes	reactome/R-HSA-8987033.md	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	168	R-HSA-8987040	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1	yes	reactome/R-HSA-8987040.md	IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	169	R-HSA-8987042	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	yes	reactome/R-HSA-8987042.md	IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	170	R-HSA-8987063	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3	yes	reactome/R-HSA-8987063.md	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	171	R-HSA-8987070	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987070.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	172	R-HSA-8987084	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1	yes	reactome/R-HSA-8987084.md	IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	173	R-HSA-8987096	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987096.md	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	174	R-HSA-8987132	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	yes	reactome/R-HSA-8987132.md	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	175	R-HSA-8987161	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3	yes	reactome/R-HSA-8987161.md	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	176	R-HSA-8987202	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	yes	reactome/R-HSA-8987202.md	IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	177	R-HSA-8987236	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-8987236.md	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	178	R-HSA-8987266	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	yes	reactome/R-HSA-8987266.md	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	179	R-HSA-9009227	IL20 binds to IL22RA1:JAK1:IL20RB	yes	reactome/R-HSA-9009227.md	IL20 binds to IL22RA1:JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	180	R-HSA-1067651	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)	yes	reactome/R-HSA-1067651.md	IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	181	R-HSA-1067659	Assembly of hexameric IL-6 receptor	yes	reactome/R-HSA-1067659.md	Assembly of hexameric IL-6 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	182	R-HSA-1067688	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)	yes	reactome/R-HSA-1067688.md	IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	183	R-HSA-1112514	JAK activation	yes	reactome/R-HSA-1112514.md	JAK activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	184	R-HSA-1169406	ISGylation of host proteins	yes	reactome/R-HSA-1169406.md	ISGylation of host proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	185	R-HSA-1295540	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	yes	reactome/R-HSA-1295540.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	186	R-HSA-1678841	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18	yes	reactome/R-HSA-1678841.md	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	187	R-HSA-448427	Interleukin-27 binds Interleukin-27 receptor	yes	reactome/R-HSA-448427.md	Interleukin-27 binds Interleukin-27 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	188	R-HSA-448480	IL22 binds IL22RA1:JAK1 receptor complex	yes	reactome/R-HSA-448480.md	IL22 binds IL22RA1:JAK1 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	189	R-HSA-448660	IL31:IL31RA:JAK1 binds OSMR:JAK1	yes	reactome/R-HSA-448660.md	IL31:IL31RA:JAK1 binds OSMR:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	190	R-HSA-448661	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1	yes	reactome/R-HSA-448661.md	IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	191	R-HSA-448708	IL24 binds to IL22RA1:JAK1:IL20RB	yes	reactome/R-HSA-448708.md	IL24 binds to IL22RA1:JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	192	R-HSA-448728	IL19 binds IL20RA:JAK1:IL20RB	yes	reactome/R-HSA-448728.md	IL19 binds IL20RA:JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	193	R-HSA-448744	IL20RA binds IL20RB	yes	reactome/R-HSA-448744.md	IL20RA binds IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	194	R-HSA-449115	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3	yes	reactome/R-HSA-449115.md	IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	195	R-HSA-449803	IL10 dimer binds IL10RA:JAK1	yes	reactome/R-HSA-449803.md	IL10 dimer binds IL10RA:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	196	R-HSA-449811	IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2	yes	reactome/R-HSA-449811.md	IL10 dimer:2xIL10RA1:JAK1 binds IL10RB:TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	197	R-HSA-449958	IL7:IL7R:JAK1 binds IL2RG:JAK3	yes	reactome/R-HSA-449958.md	IL7:IL7R:JAK1 binds IL2RG:JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	198	R-HSA-449976	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)	yes	reactome/R-HSA-449976.md	IL11:IL11RA binds IL6ST:JAK1,JAK2,(TYK2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	199	R-HSA-449978	IL7 binds IL7R:JAK1	yes	reactome/R-HSA-449978.md	IL7 binds IL7R:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	200	R-HSA-450027	Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta	yes	reactome/R-HSA-450027.md	Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	201	R-HSA-450063	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit	yes	reactome/R-HSA-450063.md	Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	202	R-HSA-451900	IL2RB binds JAK1	yes	reactome/R-HSA-451900.md	IL2RB binds JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	203	R-HSA-451942	Within the IL-2R complex JAK3 phosphorylates JAK1	yes	reactome/R-HSA-451942.md	Within the IL-2R complex JAK3 phosphorylates JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	204	R-HSA-5696482	CTF1 binds LIFR:JAKs	yes	reactome/R-HSA-5696482.md	CTF1 binds LIFR:JAKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	205	R-HSA-6783524	OSM,LIF,CTF1 receptor complex binds gp130	yes	reactome/R-HSA-6783524.md	OSM,LIF,CTF1 receptor complex binds gp130	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	206	R-HSA-6783530	gp130:JAKs bind CNTFR	yes	reactome/R-HSA-6783530.md	gp130:JAKs bind CNTFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	207	R-HSA-6783552	OSM binds LIFR:JAKs,OSMR:JAKs	yes	reactome/R-HSA-6783552.md	OSM binds LIFR:JAKs,OSMR:JAKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	208	R-HSA-6783556	LIFR:JAKs bind gp130:JAKs:CNTFR	yes	reactome/R-HSA-6783556.md	LIFR:JAKs bind gp130:JAKs:CNTFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	209	R-HSA-6783681	LIF binds LIFR	yes	reactome/R-HSA-6783681.md	LIF binds LIFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	210	R-HSA-6784189	JAKs bind LIFR	yes	reactome/R-HSA-6784189.md	JAKs bind LIFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	211	R-HSA-6784204	JAKs bind OSMR	yes	reactome/R-HSA-6784204.md	JAKs bind OSMR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	212	R-HSA-6784319	JAK1,TYK2 phosphorylate JAK1,TYK2	yes	reactome/R-HSA-6784319.md	JAK1,TYK2 phosphorylate JAK1,TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	213	R-HSA-6785165	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	yes	reactome/R-HSA-6785165.md	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	214	R-HSA-6786050	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated	yes	reactome/R-HSA-6786050.md	IL4R, IL13RA, JAK2 and TYK2 are tyrosine phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	215	R-HSA-6786058	JAK1 binds IL4R in IL4-bound IL4R1	yes	reactome/R-HSA-6786058.md	JAK1 binds IL4R in IL4-bound IL4R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	216	R-HSA-6786096	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	yes	reactome/R-HSA-6786096.md	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	217	R-HSA-6786110	JAK1 binds IL4R in IL13-bound IL13R type II	yes	reactome/R-HSA-6786110.md	JAK1 binds IL4R in IL13-bound IL13R type II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	218	R-HSA-6788571	STAT1,STAT3,STAT6 bind IL13:IL13R type II	yes	reactome/R-HSA-6788571.md	STAT1,STAT3,STAT6 bind IL13:IL13R type II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	219	R-HSA-6788582	STAT1,STAT3,STAT6 phosphorylation	yes	reactome/R-HSA-6788582.md	STAT1,STAT3,STAT6 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	220	R-HSA-6788628	p-Y-STATs dissociate	yes	reactome/R-HSA-6788628.md	p-Y-STATs dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	221	R-HSA-6809140	IL35 binds IL-12RB2:IL6ST receptor	yes	reactome/R-HSA-6809140.md	IL35 binds IL-12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	222	R-HSA-873918	Transphosphorylation of JAK1	yes	reactome/R-HSA-873918.md	Transphosphorylation of JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	223	R-HSA-873919	Phosphorylation of JAK2	yes	reactome/R-HSA-873919.md	Phosphorylation of JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	224	R-HSA-873926	IFNG dimer binds IFNGR	yes	reactome/R-HSA-873926.md	IFNG dimer binds IFNGR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	225	R-HSA-877269	SOCS-1 and SOCS-3 binds to p-JAK2	yes	reactome/R-HSA-877269.md	SOCS-1 and SOCS-3 binds to p-JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	226	R-HSA-8854645	IL22:IL22RA1:JAK1 binds IL10RB:TYK2	yes	reactome/R-HSA-8854645.md	IL22:IL22RA1:JAK1 binds IL10RB:TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	227	R-HSA-8950210	Interleukin-27 dissociates from Interleukin-27 receptor	yes	reactome/R-HSA-8950210.md	Interleukin-27 dissociates from Interleukin-27 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	228	R-HSA-8950448	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex	yes	reactome/R-HSA-8950448.md	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	229	R-HSA-8950757	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated	yes	reactome/R-HSA-8950757.md	IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	230	R-HSA-8952807	p-Y693-STAT4 dissociates after IL12:IL12R interaction	yes	reactome/R-HSA-8952807.md	p-Y693-STAT4 dissociates after IL12:IL12R interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	231	R-HSA-8963734	IL9 binds IL9R:JAK1 and IL2RG:JAK3	yes	reactome/R-HSA-8963734.md	IL9 binds IL9R:JAK1 and IL2RG:JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	232	R-HSA-8983003	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2	yes	reactome/R-HSA-8983003.md	IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	233	R-HSA-8983063	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated	yes	reactome/R-HSA-8983063.md	JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	234	R-HSA-8983298	IL15 binds IL2RB:JAK1 and IL2RG:JAK3	yes	reactome/R-HSA-8983298.md	IL15 binds IL2RB:JAK1 and IL2RG:JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	235	R-HSA-8983335	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	yes	reactome/R-HSA-8983335.md	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	236	R-HSA-8983518	IL35 binds IL6ST:IL6ST receptor	yes	reactome/R-HSA-8983518.md	IL35 binds IL6ST:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	237	R-HSA-8984001	IL35 binds IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984001.md	IL35 binds IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	238	R-HSA-8985900	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	yes	reactome/R-HSA-8985900.md	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	239	R-HSA-8985914	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3	yes	reactome/R-HSA-8985914.md	IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	240	R-HSA-8985929	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	yes	reactome/R-HSA-8985929.md	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	241	R-HSA-8985973	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3	yes	reactome/R-HSA-8985973.md	IL9R is phosphorylated by IL9:IL9R:JAK1:IL2RG:p-Y904,939-JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	242	R-HSA-8985988	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	yes	reactome/R-HSA-8985988.md	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	243	R-HSA-8986446	IL26 binds IL20RA:JAK1	yes	reactome/R-HSA-8986446.md	IL26 binds IL20RA:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	244	R-HSA-8986480	IL26:IL20RA:JAK1 binds IL10RB:TYK2	yes	reactome/R-HSA-8986480.md	IL26:IL20RA:JAK1 binds IL10RB:TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	245	R-HSA-8986972	IL24 binds IL20RA:JAK1:IL20RB	yes	reactome/R-HSA-8986972.md	IL24 binds IL20RA:JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	246	R-HSA-8987015	IL20 binds IL20RA:JAK1:IL20RB	yes	reactome/R-HSA-8987015.md	IL20 binds IL20RA:JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	247	R-HSA-8987039	JAK1 binds IL20RA	yes	reactome/R-HSA-8987039.md	JAK1 binds IL20RA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	248	R-HSA-8987043	IL22RA1 binds JAK1	yes	reactome/R-HSA-8987043.md	IL22RA1 binds JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	249	R-HSA-8987104	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3	yes	reactome/R-HSA-8987104.md	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	250	R-HSA-8987105	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1	yes	reactome/R-HSA-8987105.md	IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	251	R-HSA-8987120	JAK1 binds IFNLR1	yes	reactome/R-HSA-8987120.md	JAK1 binds IFNLR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	252	R-HSA-8987141	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987141.md	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	253	R-HSA-8987156	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3	yes	reactome/R-HSA-8987156.md	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	254	R-HSA-8987179	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3	yes	reactome/R-HSA-8987179.md	IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	255	R-HSA-8987220	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3	yes	reactome/R-HSA-8987220.md	IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	256	R-HSA-9005980	IL21 binds IL21R:JAK1	yes	reactome/R-HSA-9005980.md	IL21 binds IL21R:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	257	R-HSA-9006844	IL21:IL21R:JAK1 binds IL2RG:JAK3	yes	reactome/R-HSA-9006844.md	IL21:IL21R:JAK1 binds IL2RG:JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	258	R-HSA-9006850	IL21 receptor JAK phosphorylation	yes	reactome/R-HSA-9006850.md	IL21 receptor JAK phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	259	R-HSA-9011748	IL9R binds JAK1	yes	reactome/R-HSA-9011748.md	IL9R binds JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	260	R-HSA-9025969	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	yes	reactome/R-HSA-9025969.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	261	R-HSA-909720	IFN alpha/beta binds to IFNAR2	yes	reactome/R-HSA-909720.md	IFN alpha/beta binds to IFNAR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	262	R-HSA-909724	Recruitment of IFNAR1	yes	reactome/R-HSA-909724.md	Recruitment of IFNAR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	263	R-HSA-909729	Activation of JAK kinases	yes	reactome/R-HSA-909729.md	Activation of JAK kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	264	R-HSA-9677579	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN	yes	reactome/R-HSA-9677579.md	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	265	R-HSA-9677585	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1	yes	reactome/R-HSA-9677585.md	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	266	R-HSA-9678561	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors	yes	reactome/R-HSA-9678561.md	IFNGR1:JAK1:INFGR2:JAK2 binds JAK1,2 inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	267	R-HSA-9678935	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors	yes	reactome/R-HSA-9678935.md	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	268	R-HSA-9696179	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs	yes	reactome/R-HSA-9696179.md	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	269	R-HSA-997314	Dephosphorylation of JAK1 by SHP1	yes	reactome/R-HSA-997314.md	Dephosphorylation of JAK1 by SHP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	270	R-HSA-8983335	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	yes	reactome/R-HSA-8983335.md	IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome	Homo sapiens	GO:0005768	endosome	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome reaction describes the IL-15 receptor complex (including JAK1) translocating from the plasma membrane to the endosome, so JAK1 transiently localizes to the endosome as part of internalized receptor complexes.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	274	R-HSA-1112510	IL6ST is tyrosine phosphorylated	yes	reactome/R-HSA-1112510.md	IL6ST is tyrosine phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	275	R-HSA-1112565	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	yes	reactome/R-HSA-1112565.md	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	276	R-HSA-1112602	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	yes	reactome/R-HSA-1112602.md	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	277	R-HSA-1112604	Phosphorylated STATs are released	yes	reactome/R-HSA-1112604.md	Phosphorylated STATs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	278	R-HSA-1112690	PTPN11 binds CBL	yes	reactome/R-HSA-1112690.md	PTPN11 binds CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	279	R-HSA-1112703	PTPN11 is phosphorylated	yes	reactome/R-HSA-1112703.md	PTPN11 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	280	R-HSA-1112708	PTPN11 binds p-Y759-IL6ST	yes	reactome/R-HSA-1112708.md	PTPN11 binds p-Y759-IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	281	R-HSA-1112727	Serine phosphorylation of STATs	yes	reactome/R-HSA-1112727.md	Serine phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	282	R-HSA-1112755	SOCS3 binds IL6ST	yes	reactome/R-HSA-1112755.md	SOCS3 binds IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	283	R-HSA-452091	Phosphorylation of IL2RB Y338 enables SHC recruitment	yes	reactome/R-HSA-452091.md	Phosphorylation of IL2RB Y338 enables SHC recruitment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	284	R-HSA-452097	Recruited STAT5 is phosphorylated	yes	reactome/R-HSA-452097.md	Recruited STAT5 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	285	R-HSA-452100	SHC1 bound to IL2 receptor is phosphorylated	yes	reactome/R-HSA-452100.md	SHC1 bound to IL2 receptor is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	286	R-HSA-452108	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	yes	reactome/R-HSA-452108.md	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	287	R-HSA-452122	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	yes	reactome/R-HSA-452122.md	JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	288	R-HSA-453104	Phosphorylated SHC1 recruits GRB2:GAB2	yes	reactome/R-HSA-453104.md	Phosphorylated SHC1 recruits GRB2:GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	289	R-HSA-453111	Phosphorylated SHC recruits GRB2:SOS1	yes	reactome/R-HSA-453111.md	Phosphorylated SHC recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	290	R-HSA-508247	Gab2 binds the p85 subunit of Class 1A PI3 kinases	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	291	R-HSA-508282	SYK is a substrate for JAK1	yes	reactome/R-HSA-508282.md	SYK is a substrate for JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	292	R-HSA-508292	SYK binds IL2RB	yes	reactome/R-HSA-508292.md	SYK binds IL2RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	293	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	294	R-HSA-6784006	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	yes	reactome/R-HSA-6784006.md	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	295	R-HSA-6784323	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	yes	reactome/R-HSA-6784323.md	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	296	R-HSA-6784324	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA	yes	reactome/R-HSA-6784324.md	p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	297	R-HSA-6784791	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-6784791.md	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	298	R-HSA-6786072	p-Y705-STAT3,p-Y641-STAT6 dissociate	yes	reactome/R-HSA-6786072.md	p-Y705-STAT3,p-Y641-STAT6 dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	299	R-HSA-6786095	JAK1 phosphorylates STAT3,STAT6	yes	reactome/R-HSA-6786095.md	JAK1 phosphorylates STAT3,STAT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	300	R-HSA-6786124	STAT3,STAT6 bind p-Y-IL4R	yes	reactome/R-HSA-6786124.md	STAT3,STAT6 bind p-Y-IL4R	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	301	R-HSA-873921	Binding of STAT1 to p-IFNGR1	yes	reactome/R-HSA-873921.md	Binding of STAT1 to p-IFNGR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	302	R-HSA-873922	Phosphorylation of STAT1 by JAK kinases	yes	reactome/R-HSA-873922.md	Phosphorylation of STAT1 by JAK kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	303	R-HSA-873924	Phosphorylation of IFNGR1 by JAK kinases	yes	reactome/R-HSA-873924.md	Phosphorylation of IFNGR1 by JAK kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	304	R-HSA-873927	Release of STAT1 dimer from active receptor unit	yes	reactome/R-HSA-873927.md	Release of STAT1 dimer from active receptor unit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	305	R-HSA-8983371	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	yes	reactome/R-HSA-8983371.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	306	R-HSA-8983374	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	yes	reactome/R-HSA-8983374.md	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	307	R-HSA-8983378	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	yes	reactome/R-HSA-8983378.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	308	R-HSA-8983384	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	yes	reactome/R-HSA-8983384.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	309	R-HSA-9006870	IL21 receptor STAT phosphorylation	yes	reactome/R-HSA-9006870.md	IL21 receptor STAT phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	310	R-HSA-9006873	IL21 receptor STAT binding	yes	reactome/R-HSA-9006873.md	IL21 receptor STAT binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	311	R-HSA-909552	Phosphorylation of STAT1 at Ser727	yes	reactome/R-HSA-909552.md	Phosphorylation of STAT1 at Ser727	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	312	R-HSA-909718	Formation of p-STAT1 homodimer	yes	reactome/R-HSA-909718.md	Formation of p-STAT1 homodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	313	R-HSA-909719	Recruitment of STAT2 to p-IFNAR1	yes	reactome/R-HSA-909719.md	Recruitment of STAT2 to p-IFNAR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	314	R-HSA-909722	Release of p-STAT2:p-STAT1 dimer	yes	reactome/R-HSA-909722.md	Release of p-STAT2:p-STAT1 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	315	R-HSA-909726	Phosphorylation of STAT1	yes	reactome/R-HSA-909726.md	Phosphorylation of STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	316	R-HSA-909730	Phosphorylation of INFAR1 by TYK2	yes	reactome/R-HSA-909730.md	Phosphorylation of INFAR1 by TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	317	R-HSA-909732	Phosphorylation of STAT2	yes	reactome/R-HSA-909732.md	Phosphorylation of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	318	R-HSA-912527	SHC1 mediates cytokine-induced phosphorylation of GAB2	yes	reactome/R-HSA-912527.md	SHC1 mediates cytokine-induced phosphorylation of GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	319	R-HSA-913374	Phosphorylated SHC1 recruits SHIP	yes	reactome/R-HSA-913374.md	Phosphorylated SHC1 recruits SHIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	320	R-HSA-913424	The SHC1:SHIP1 complex is stabilized by GRB2	yes	reactome/R-HSA-913424.md	The SHC1:SHIP1 complex is stabilized by GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	321	R-HSA-919404	Phosphorylated STAT5 is released	yes	reactome/R-HSA-919404.md	Phosphorylated STAT5 is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	322	R-HSA-9674816	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	yes	reactome/R-HSA-9674816.md	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	323	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	324	R-HSA-9707977	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	yes	reactome/R-HSA-9707977.md	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	325	R-HSA-9732729	Activated JAK1 binds RAF1	yes	reactome/R-HSA-9732729.md	Activated JAK1 binds RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	326	R-HSA-9732738	JAK1-mediated phosphorylation of RAF1	yes	reactome/R-HSA-9732738.md	JAK1-mediated phosphorylation of RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	327	R-HSA-9732753	JAK1-activated RAF1 phosphorylates MAPKs	yes	reactome/R-HSA-9732753.md	JAK1-activated RAF1 phosphorylates MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	328	R-HSA-997309	Dephosphorylation of STAT1 by SHP2	yes	reactome/R-HSA-997309.md	Dephosphorylation of STAT1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	329	R-HSA-997311	Dephosphorylation of TYK2 by PTP1B	yes	reactome/R-HSA-997311.md	Dephosphorylation of TYK2 by PTP1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	JAK1 is a cytosolic non-receptor tyrosine kinase recruited to the cytoplasmic tails of cytokine receptors at the plasma membrane. This is one of a large set of bulk Reactome TAS annotations placing JAK1 reaction participants in the cytosol; the cytosolic localization is correct and consistent with JAK1's role as a soluble kinase.
human	JAK1	genes/human/JAK1/JAK1-ai-review.yaml	JAK1	P23458	NCBITaxon:9606	Homo sapiens	332	R-HSA-9006844	IL21:IL21R:JAK1 binds IL2RG:JAK3	yes	reactome/R-HSA-9006844.md	IL21:IL21R:JAK1 binds IL2RG:JAK3	Homo sapiens	GO:0038114	interleukin-21-mediated signaling pathway	TAS	involved_in	BP	false		NEW	IL-21 signals through the IL-21 receptor (IL21R) together with the common gamma chain, where JAK1 (bound to IL21R) pairs with JAK3 to phosphorylate the receptor and STAT factors. JAK1 is the receptor-proximal kinase for IL-21, a gamma-c cytokine. This annotation is not otherwise present in the GOA set but is well-supported by Reactome IL-21 receptor reactions.
human	KCTD7	genes/human/KCTD7/KCTD7-ai-review.yaml	KCTD7	Q96MP8	NCBITaxon:9606	Homo sapiens	13	R-HSA-8952630	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952630.md	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex."" KCTD7 participates in CRL3 complexes as a BTB adaptor."
human	KCTD7	genes/human/KCTD7/KCTD7-ai-review.yaml	KCTD7	Q96MP8	NCBITaxon:9606	Homo sapiens	14	R-HSA-8952631	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952631.md	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex."""
human	KCTD7	genes/human/KCTD7/KCTD7-ai-review.yaml	KCTD7	Q96MP8	NCBITaxon:9606	Homo sapiens	15	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""CAND1 binds cytosolic CRL E3 ubiquitin ligases."""
human	KCTD7	genes/human/KCTD7/KCTD7-ai-review.yaml	KCTD7	Q96MP8	NCBITaxon:9606	Homo sapiens	16	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes."""
human	KCTD7	genes/human/KCTD7/KCTD7-ai-review.yaml	KCTD7	Q96MP8	NCBITaxon:9606	Homo sapiens	17	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes."""
human	KDSR	genes/human/KDSR/KDSR-ai-review.yaml	KDSR	Q06136	NCBITaxon:9606	Homo sapiens	10	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation placing KDSR in de novo sphingolipid biosynthesis.
human	KDSR	genes/human/KDSR/KDSR-ai-review.yaml	KDSR	Q06136	NCBITaxon:9606	Homo sapiens	12	R-HSA-428123	KDSR reduces 3-ketosphingoid	yes	reactome/R-HSA-428123.md	KDSR reduces 3-ketosphingoid	Homo sapiens	GO:0047560	3-dehydrosphinganine reductase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable annotation of the KDS reductase molecular function (reaction ""KDSR reduces 3-ketosphingoid"")."
human	KDSR	genes/human/KDSR/KDSR-ai-review.yaml	KDSR	Q06136	NCBITaxon:9606	Homo sapiens	29	R-HSA-428123	KDSR reduces 3-ketosphingoid	yes	reactome/R-HSA-428123.md	KDSR reduces 3-ketosphingoid	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation of ER membrane localization.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	66	R-HSA-9766645	Reactome pathway annotation	yes	reactome/R-HSA-9766645.md	CUL3:RBX1 ubiquitinates KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for KEAP1 cytosolic localization.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	67	R-HSA-9766656	Reactome pathway annotation	yes	reactome/R-HSA-9766656.md	RBX1:CUL3 dissociates from forming autophagosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for KEAP1 cytosolic localization.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	68	R-HSA-9766677	Reactome pathway annotation	yes	reactome/R-HSA-9766677.md	MAP1LC3B binds KEAP1 and SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for KEAP1 cytosolic localization.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	79	R-HSA-6781764	Reactome pathway annotation	yes	reactome/R-HSA-6781764.md	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	88	R-HSA-8932327	Reactome pathway annotation	yes	reactome/R-HSA-8932327.md	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for cytosol localization.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	89	R-HSA-8952630	Reactome pathway annotation	yes	reactome/R-HSA-8952630.md	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	90	R-HSA-8952631	Reactome pathway annotation	yes	reactome/R-HSA-8952631.md	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	91	R-HSA-8955241	Reactome pathway annotation	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	92	R-HSA-8955289	Reactome pathway annotation	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	93	R-HSA-8956040	Reactome pathway annotation	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	94	R-HSA-9712274	Reactome pathway annotation	yes	reactome/R-HSA-9712274.md	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	95	R-HSA-9755505	Reactome pathway annotation	yes	reactome/R-HSA-9755505.md	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	96	R-HSA-9755507	Reactome pathway annotation	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	97	R-HSA-9758090	Reactome pathway annotation	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	98	R-HSA-9759169	Reactome pathway annotation	yes	reactome/R-HSA-9759169.md	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	99	R-HSA-9759172	Reactome pathway annotation	yes	reactome/R-HSA-9759172.md	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	100	R-HSA-9766687	Reactome pathway annotation	yes	reactome/R-HSA-9766687.md	SESN1,SESN1 bind SQSTM1 and KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KEAP1	genes/human/KEAP1/KEAP1-ai-review.yaml	KEAP1	Q14145	NCBITaxon:9606	Homo sapiens	101	R-HSA-9796040	Reactome pathway annotation	yes	reactome/R-HSA-9796040.md	NFE2L2 dependent KEAP1 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	KHK	genes/human/KHK/KHK-ai-review.yaml	KHK	P50053	NCBITaxon:9606	Homo sapiens	14	R-HSA-5656459	Defective KHK does not phosphorylate beta-D-fructose	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation placing KHK in the cytosol, from the ""Defective KHK does not phosphorylate beta-D-fructose"" reaction (the essential-fructosuria variant reaction). KHK is a soluble cytosolic enzyme."
human	KHK	genes/human/KHK/KHK-ai-review.yaml	KHK	P50053	NCBITaxon:9606	Homo sapiens	16	R-HSA-70333	KHK dimer phosphorylates Fru to Fru 1-P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation placing KHK in the cytosol, from the ""KHK dimer phosphorylates Fru to Fru 1-P"" reaction. The enzyme is explicitly described as cytosolic."
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	42	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	43	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	44	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	45	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	46	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	47	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	48	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIF5B	genes/human/KIF5B/KIF5B-ai-review.yaml	KIF5B	P33176	NCBITaxon:9606	Homo sapiens	52	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KIF5B is a cytosolic/cytoplasmic motor protein, but this broad localization does not describe the specific motor function.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	15	R-HSA-9669890	Constitutive phosphorylation of kinase domain KIT mutants	yes	reactome/R-HSA-9669890.md	Constitutive phosphorylation of kinase domain KIT mutants	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	KIT is a protein tyrosine kinase (EC 2.7.10.1); accurate core molecular function.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	107	R-HSA-1433418	Phosphorylation of JAK2	yes	reactome/R-HSA-1433418.md	Phosphorylation of JAK2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	108	R-HSA-1433423	PTP-RO interacts with p-c-Kit complex	yes	reactome/R-HSA-1433423.md	PTP-RO interacts with p-c-Kit complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	109	R-HSA-1433428	GRB2 is indirectly recruited to p-KIT through SHP2	yes	reactome/R-HSA-1433428.md	GRB2 is indirectly recruited to p-KIT through SHP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	110	R-HSA-1433451	JAK2 binds to p-KIT	yes	reactome/R-HSA-1433451.md	JAK2 binds to p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	111	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	yes	reactome/R-HSA-1433454.md	Phosphorylation of GAB2 by SFKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	112	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	113	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	114	R-HSA-1433488	Phosphorylation of SHP2 by SFKs	yes	reactome/R-HSA-1433488.md	Phosphorylation of SHP2 by SFKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	115	R-HSA-1433501	Interaction of other adapter proteins with p-KIT	yes	reactome/R-HSA-1433501.md	Interaction of other adapter proteins with p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	116	R-HSA-1433506	Phosphorylation of APS	yes	reactome/R-HSA-1433506.md	Phosphorylation of APS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	117	R-HSA-1433508	PKC alpha interacts with and phosphorylates KIT	yes	reactome/R-HSA-1433508.md	PKC alpha interacts with and phosphorylates KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	118	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	119	R-HSA-1433542	Phosphorylation and activation of VAV1	yes	reactome/R-HSA-1433542.md	Phosphorylation and activation of VAV1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	120	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	121	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	122	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	123	R-HSA-1472121	Phosphorylation of p-KIT on Y900 by Src kinases	yes	reactome/R-HSA-1472121.md	Phosphorylation of p-KIT on Y900 by Src kinases	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	124	R-HSA-1562640	LNK binds to p-KIT and inhibit downstream signaling	yes	reactome/R-HSA-1562640.md	LNK binds to p-KIT and inhibit downstream signaling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	125	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	126	R-HSA-205231	Dimerization of KIT upon SCF binding	yes	reactome/R-HSA-205231.md	Dimerization of KIT upon SCF binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	127	R-HSA-205234	Indirect recruitment of GAB2 to p-KIT	yes	reactome/R-HSA-205234.md	Indirect recruitment of GAB2 to p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	128	R-HSA-205238	SHP2 interacts with p-KIT	yes	reactome/R-HSA-205238.md	SHP2 interacts with p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	129	R-HSA-205244	Recruitment of CBL to KIT	yes	reactome/R-HSA-205244.md	Recruitment of CBL to KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	130	R-HSA-205262	Direct recruitment of PI3K to p-KIT	yes	reactome/R-HSA-205262.md	Direct recruitment of PI3K to p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	131	R-HSA-205286	GRB2:SOS interacts with p-KIT	yes	reactome/R-HSA-205286.md	GRB2:SOS interacts with p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	132	R-HSA-205289	Autophosphorylation of KIT	yes	reactome/R-HSA-205289.md	Autophosphorylation of KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	133	R-HSA-205306	Interaction of SHP1 and KIT	yes	reactome/R-HSA-205306.md	Interaction of SHP1 and KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	134	R-HSA-205319	Interaction of APS and p-KIT	yes	reactome/R-HSA-205319.md	Interaction of APS and p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	135	R-HSA-205321	Interaction of KIT and sSCF	yes	reactome/R-HSA-205321.md	Interaction of KIT and sSCF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	136	R-HSA-205328	Interaction of other tyrosine kinases with p-KIT	yes	reactome/R-HSA-205328.md	Interaction of other tyrosine kinases with p-KIT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	137	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	138	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	139	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	140	R-HSA-8864698	KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers	yes	reactome/R-HSA-8864698.md	KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	141	R-HSA-9669854	KIT binds type II TKIs	yes	reactome/R-HSA-9669854.md	KIT binds type II TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	142	R-HSA-9669855	Dasatinib-resistant KIT mutants do not bind dasatinib	yes	reactome/R-HSA-9669855.md	Dasatinib-resistant KIT mutants do not bind dasatinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	143	R-HSA-9669859	Imatinib-resistant KIT mutants do not bind imatinib	yes	reactome/R-HSA-9669859.md	Imatinib-resistant KIT mutants do not bind imatinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	144	R-HSA-9669863	Masitinib-resistant KIT mutants do not bind masitinib	yes	reactome/R-HSA-9669863.md	Masitinib-resistant KIT mutants do not bind masitinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	145	R-HSA-9669868	Nilotinib-resistant KIT mutants do not bind nilotinib	yes	reactome/R-HSA-9669868.md	Nilotinib-resistant KIT mutants do not bind nilotinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	146	R-HSA-9669870	Regorafenib-resistant KIT mutants do not bind regorafenib	yes	reactome/R-HSA-9669870.md	Regorafenib-resistant KIT mutants do not bind regorafenib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	147	R-HSA-9669874	Sorafenib-resistant KIT mutants do not bind sorafenib	yes	reactome/R-HSA-9669874.md	Sorafenib-resistant KIT mutants do not bind sorafenib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	148	R-HSA-9669878	Sunitinib-resistant KIT mutants do not bind sunitinib	yes	reactome/R-HSA-9669878.md	Sunitinib-resistant KIT mutants do not bind sunitinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	149	R-HSA-9669890	Constitutive phosphorylation of kinase domain KIT mutants	yes	reactome/R-HSA-9669890.md	Constitutive phosphorylation of kinase domain KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	150	R-HSA-9669893	KIT binds type I TKIs	yes	reactome/R-HSA-9669893.md	KIT binds type I TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	151	R-HSA-9669898	KIT mutants bind type I TKIs	yes	reactome/R-HSA-9669898.md	KIT mutants bind type I TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	152	R-HSA-9669900	KIT mutants bind type II TKIs	yes	reactome/R-HSA-9669900.md	KIT mutants bind type II TKIs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	153	R-HSA-9669906	Ligand-independent dimerization of KIT juxtamembrane domain mutants	yes	reactome/R-HSA-9669906.md	Ligand-independent dimerization of KIT juxtamembrane domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	154	R-HSA-9669911	Phosphorylation of juxtamembrane domain KIT mutants	yes	reactome/R-HSA-9669911.md	Phosphorylation of juxtamembrane domain KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	155	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	156	R-HSA-9670413	JAK2 binds to p-KIT mutants	yes	reactome/R-HSA-9670413.md	JAK2 binds to p-KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	157	R-HSA-9670414	KIT mutants bind SFKs	yes	reactome/R-HSA-9670414.md	KIT mutants bind SFKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	158	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	159	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	160	R-HSA-9670418	Phosphorylation of JAK2 downstream of KIT mutants	yes	reactome/R-HSA-9670418.md	Phosphorylation of JAK2 downstream of KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	161	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	162	R-HSA-9670428	KIT mutants bind GRB2-SOS	yes	reactome/R-HSA-9670428.md	KIT mutants bind GRB2-SOS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	163	R-HSA-9670431	Phosphorylated KIT mutants bind PI3K	yes	reactome/R-HSA-9670431.md	Phosphorylated KIT mutants bind PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	164	R-HSA-9670433	KIT mutants:PI3K catalyze synthesis of PIP3	yes	reactome/R-HSA-9670433.md	KIT mutants:PI3K catalyze synthesis of PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	165	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	166	R-HSA-9680242	Ligand-independent dimerization of KIT extracellular domain mutants	yes	reactome/R-HSA-9680242.md	Ligand-independent dimerization of KIT extracellular domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	167	R-HSA-9680248	Phosphorylation of extracellular domain KIT mutants	yes	reactome/R-HSA-9680248.md	Phosphorylation of extracellular domain KIT mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	168	R-HSA-9681375	KIT binds ripretinib	yes	reactome/R-HSA-9681375.md	KIT binds ripretinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KIT	genes/human/KIT/KIT-ai-review.yaml	KIT	P10721	NCBITaxon:9606	Homo sapiens	169	R-HSA-9681382	KIT mutants bind ripretinib	yes	reactome/R-HSA-9681382.md	KIT mutants bind ripretinib	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Core cellular location: mature KIT is a plasma-membrane receptor.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	8	R-HSA-1433374	Processing of SCF isoform 1	yes	reactome/R-HSA-1433374.md	Processing of SCF isoform 1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome-derived location for the soluble/secreted SCF form participating in SCF-KIT signaling reactions. Correct location for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	9	R-HSA-1433395	Dimerization of sSCF	yes	reactome/R-HSA-1433395.md	Dimerization of sSCF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	10	R-HSA-1433418	Phosphorylation of JAK2	yes	reactome/R-HSA-1433418.md	Phosphorylation of JAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	11	R-HSA-1433428	GRB2 is indirectly recruited to p-KIT through SHP2	yes	reactome/R-HSA-1433428.md	GRB2 is indirectly recruited to p-KIT through SHP2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	12	R-HSA-1433451	JAK2 binds to p-KIT	yes	reactome/R-HSA-1433451.md	JAK2 binds to p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	13	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	yes	reactome/R-HSA-1433454.md	Phosphorylation of GAB2 by SFKs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	14	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	15	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	16	R-HSA-1433488	Phosphorylation of SHP2 by SFKs	yes	reactome/R-HSA-1433488.md	Phosphorylation of SHP2 by SFKs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	17	R-HSA-1433501	Interaction of other adapter proteins with p-KIT	yes	reactome/R-HSA-1433501.md	Interaction of other adapter proteins with p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	18	R-HSA-1433506	Phosphorylation of APS	yes	reactome/R-HSA-1433506.md	Phosphorylation of APS	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	19	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	20	R-HSA-1433542	Phosphorylation and activation of VAV1	yes	reactome/R-HSA-1433542.md	Phosphorylation and activation of VAV1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	21	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	22	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	23	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	24	R-HSA-1472121	Phosphorylation of p-KIT on Y900 by Src kinases	yes	reactome/R-HSA-1472121.md	Phosphorylation of p-KIT on Y900 by Src kinases	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	25	R-HSA-1562640	LNK binds to p-KIT and inhibit downstream signaling	yes	reactome/R-HSA-1562640.md	LNK binds to p-KIT and inhibit downstream signaling	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	26	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	27	R-HSA-205231	Dimerization of KIT upon SCF binding	yes	reactome/R-HSA-205231.md	Dimerization of KIT upon SCF binding	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	28	R-HSA-205234	Indirect recruitment of GAB2 to p-KIT	yes	reactome/R-HSA-205234.md	Indirect recruitment of GAB2 to p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	29	R-HSA-205238	SHP2 interacts with p-KIT	yes	reactome/R-HSA-205238.md	SHP2 interacts with p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	30	R-HSA-205244	Recruitment of CBL to KIT	yes	reactome/R-HSA-205244.md	Recruitment of CBL to KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	31	R-HSA-205262	Direct recruitment of PI3K to p-KIT	yes	reactome/R-HSA-205262.md	Direct recruitment of PI3K to p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	32	R-HSA-205286	GRB2:SOS interacts with p-KIT	yes	reactome/R-HSA-205286.md	GRB2:SOS interacts with p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	33	R-HSA-205289	Autophosphorylation of KIT	yes	reactome/R-HSA-205289.md	Autophosphorylation of KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	34	R-HSA-205306	Interaction of SHP1 and KIT	yes	reactome/R-HSA-205306.md	Interaction of SHP1 and KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	35	R-HSA-205319	Interaction of APS and p-KIT	yes	reactome/R-HSA-205319.md	Interaction of APS and p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	36	R-HSA-205321	Interaction of KIT and sSCF	yes	reactome/R-HSA-205321.md	Interaction of KIT and sSCF	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome reaction ""Interaction of KIT and sSCF"" locates the soluble SCF in the extracellular region where it engages KIT; correct for sKITLG."
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	37	R-HSA-205328	Interaction of other tyrosine kinases with p-KIT	yes	reactome/R-HSA-205328.md	Interaction of other tyrosine kinases with p-KIT	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	38	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	39	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	40	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	41	R-HSA-9669893	KIT binds type I TKIs	yes	reactome/R-HSA-9669893.md	KIT binds type I TKIs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome location annotation for secreted soluble SCF; correct for sKITLG.
human	KITLG	genes/human/KITLG/KITLG-ai-review.yaml	KITLG	P21583	NCBITaxon:9606	Homo sapiens	49	R-HSA-1433374	Processing of SCF isoform 1	yes	reactome/R-HSA-1433374.md	Processing of SCF isoform 1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome ""Processing of SCF isoform 1"" places membrane SCF at the plasma membrane prior to shedding; correct location for the transmembrane precursor."
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	7	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	8	R-HSA-1307955	FGFR4 binds HS:KLB:FGF19	yes	reactome/R-HSA-1307955.md	FGFR4 binds HS:KLB:FGF19	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	9	R-HSA-1307963	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4	yes	reactome/R-HSA-1307963.md	Autocatalytic phosphorylation of BetaKlotho-bound FGFR4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	10	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	11	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	12	R-HSA-5654151	Activated FGFR4 phosphorylates PLCG1	yes	reactome/R-HSA-5654151.md	Activated FGFR4 phosphorylates PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	13	R-HSA-5654163	Activated FGFR4 binds PLCG1	yes	reactome/R-HSA-5654163.md	Activated FGFR4 binds PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	14	R-HSA-5654169	p-4Y-PLCG1 dissociates from activated FGFR4	yes	reactome/R-HSA-5654169.md	p-4Y-PLCG1 dissociates from activated FGFR4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	15	R-HSA-5654418	Activated FGFR4 phosphorylates FRS2	yes	reactome/R-HSA-5654418.md	Activated FGFR4 phosphorylates FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	16	R-HSA-5654422	Activated FGFR4 binds FRS2	yes	reactome/R-HSA-5654422.md	Activated FGFR4 binds FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	17	R-HSA-5654423	Activated FGFR4:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654423.md	Activated FGFR4:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	18	R-HSA-5654425	Activated FGFR4 binds SHC1	yes	reactome/R-HSA-5654425.md	Activated FGFR4 binds SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	19	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	20	R-HSA-5654428	Activated FGFR4 phosphorylates SHC1	yes	reactome/R-HSA-5654428.md	Activated FGFR4 phosphorylates SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	21	R-HSA-5654566	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2	yes	reactome/R-HSA-5654566.md	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	22	R-HSA-5654651	Activated FGFR4 binds FRS3	yes	reactome/R-HSA-5654651.md	Activated FGFR4 binds FRS3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	23	R-HSA-5654653	Activated FGFR4 phosphorylates FRS3	yes	reactome/R-HSA-5654653.md	Activated FGFR4 phosphorylates FRS3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	24	R-HSA-5654655	Activated FGFR4 phosphorylates PPTN11	yes	reactome/R-HSA-5654655.md	Activated FGFR4 phosphorylates PPTN11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	25	R-HSA-5654658	Activated FGFR4:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654658.md	Activated FGFR4:p-FRS bind to PPTN11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	26	R-HSA-5654659	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	yes	reactome/R-HSA-5654659.md	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	27	R-HSA-5654662	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654662.md	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	28	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	29	R-HSA-5654664	Activated FGFR4:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654664.md	Activated FGFR4:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	30	R-HSA-5654667	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654667.md	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	31	R-HSA-5654669	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	32	R-HSA-5654684	CBL ubiquitinates FRS2 and FGFR4	yes	reactome/R-HSA-5654684.md	CBL ubiquitinates FRS2 and FGFR4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	33	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	34	R-HSA-5654717	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654717.md	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	35	R-HSA-5654734	p-CBL:GRB2 binds p-FRS2:activated FGFR4	yes	reactome/R-HSA-5654734.md	p-CBL:GRB2 binds p-FRS2:activated FGFR4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KLB	genes/human/KLB/KLB-ai-review.yaml	KLB	Q86Z14	NCBITaxon:9606	Homo sapiens	36	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	KLB is a glycosylated single-pass type III cell-surface protein; plasma-membrane placement is integral to its endocrine-FGF receptor-complex function.
human	KMO	genes/human/KMO/KMO-ai-review.yaml	KMO	O15229	NCBITaxon:9606	Homo sapiens	20	R-HSA-71240	Tryptophan catabolism	yes	reactome/R-HSA-71240.md	Tryptophan catabolism	Homo sapiens	GO:0006569	L-tryptophan catabolic process	TAS	involved_in	BP	false		ACCEPT	Traceable-author (Reactome) statement placing KMO in tryptophan catabolism. Correct and consistent with the experimental evidence. Accept.
human	KMO	genes/human/KMO/KMO-ai-review.yaml	KMO	O15229	NCBITaxon:9606	Homo sapiens	22	R-HSA-71200	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O	yes	reactome/R-HSA-71200.md	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O	Homo sapiens	GO:0004502	kynurenine 3-monooxygenase activity	TAS	enables	MF	false		ACCEPT	Traceable-author (Reactome) statement of the kynurenine 3-monooxygenase reaction (L-kynurenine + NADPH + O2 -> 3-hydroxykynurenine + NADP+ + H2O). This is the core catalytic function. Accept.
human	KMO	genes/human/KMO/KMO-ai-review.yaml	KMO	O15229	NCBITaxon:9606	Homo sapiens	23	R-HSA-71200	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O	yes	reactome/R-HSA-71200.md	kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) statement of outer mitochondrial membrane localization. Correct and consistent with the experimental EXP annotation. Accept.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	45	R-HSA-5673001	RAF/MAP kinase cascade	yes	reactome/R-HSA-5673001.md	RAF/MAP kinase cascade	Homo sapiens	GO:0000165	MAPK cascade	TAS	involved_in	BP	false		ACCEPT	KRAS participates in the RAF/MAP kinase cascade by recruiting and activating RAF-family kinases when GTP-bound.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	50	R-HSA-9649736	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		ACCEPT	TAS annotation for KRAS GTPase activity. KRAS is a Ras-family small GTPase with intrinsic GTP hydrolysis activity and GAP-stimulated hydrolysis.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	54	R-HSA-9674816	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	yes	reactome/R-HSA-9674816.md	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	55	R-HSA-9654521	Calmodulin dissociates KRAS4B from the plasma membrane	yes	reactome/R-HSA-9654521.md	Calmodulin dissociates KRAS4B from the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KRAS has a cytoplasmic/cytosolic pool during its membrane-trafficking cycle, including PDEdelta-mediated solubilization of farnesylated KRAS.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	56	R-HSA-9654523	ARL2:GTP bind PDE6D on KRAS4B	yes	reactome/R-HSA-9654523.md	ARL2:GTP bind PDE6D on KRAS4B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KRAS has a cytoplasmic/cytosolic pool during its membrane-trafficking cycle, including PDEdelta-mediated solubilization of farnesylated KRAS.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	57	R-HSA-9654525	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+	yes	reactome/R-HSA-9654525.md	PDE6D binds S-Farn-Me KRAS4B:CALM:4 Ca2+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KRAS has a cytoplasmic/cytosolic pool during its membrane-trafficking cycle, including PDEdelta-mediated solubilization of farnesylated KRAS.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	58	R-HSA-9654533	KRAS4B recycles to the plasma membrane	yes	reactome/R-HSA-9654533.md	KRAS4B recycles to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KRAS has a cytoplasmic/cytosolic pool during its membrane-trafficking cycle, including PDEdelta-mediated solubilization of farnesylated KRAS.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	59	R-HSA-9653592	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane	yes	reactome/R-HSA-9653592.md	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places phosphorylated KRAS4B at the mitochondrial outer membrane in a regulated trafficking/signaling context.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	60	R-HSA-9653595	pS181-S-Farn-Me KRAS4B binds BCL2L1	yes	reactome/R-HSA-9653595.md	pS181-S-Farn-Me KRAS4B binds BCL2L1	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places phosphorylated KRAS4B at the mitochondrial outer membrane in a regulated trafficking/signaling context.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	61	R-HSA-9653503	KRAS4B is phosphorylated on serine 181	yes	reactome/R-HSA-9653503.md	KRAS4B is phosphorylated on serine 181	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	62	R-HSA-9653592	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane	yes	reactome/R-HSA-9653592.md	pS181-S-Farn-Me KRAS4B translocates to the outer mitochondrial membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	63	R-HSA-9651280	RAS GAP mutants aren't stimulated by GAPs	yes	reactome/R-HSA-9651280.md	RAS GAP mutants aren't stimulated by GAPs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	64	R-HSA-6802834	RAS GTPase mutants don't hydrolyze GTP	yes	reactome/R-HSA-6802834.md	RAS GTPase mutants don't hydrolyze GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	65	R-HSA-6802908	RAS mutants bind inactive RAF	yes	reactome/R-HSA-6802908.md	RAS mutants bind inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	66	R-HSA-6802918	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	67	R-HSA-6802922	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	68	R-HSA-6802924	RAF is phosphorylated downstream of oncogenic RAS	yes	reactome/R-HSA-6802924.md	RAF is phosphorylated downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	69	R-HSA-6802925	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	70	R-HSA-6802926	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	71	R-HSA-6802937	Inactive BRAF mutants bind mutant RAS:GTP	yes	reactome/R-HSA-6802937.md	Inactive BRAF mutants bind mutant RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	72	R-HSA-6802941	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	yes	reactome/R-HSA-6802941.md	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	73	R-HSA-6802942	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	74	R-HSA-6802943	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	75	R-HSA-6803233	Dissociation of oncogenic RAS:RAF complex	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	76	R-HSA-6803234	Dissociation of paradoxically activated RAS:BRAF complexes	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	77	R-HSA-6803240	Homo- or heterodimerization of RAF downstream of mutant RAS	yes	reactome/R-HSA-6803240.md	Homo- or heterodimerization of RAF downstream of mutant RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	78	R-HSA-8936731	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	yes	reactome/R-HSA-8936731.md	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	79	R-HSA-9647977	ICMT methylates S-Farn RAS proteins	yes	reactome/R-HSA-9647977.md	ICMT methylates S-Farn RAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ER membrane annotations reflect CAAX processing and maturation reactions for farnesylated RAS proteins in Reactome.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	80	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ER membrane annotations reflect CAAX processing and maturation reactions for farnesylated RAS proteins in Reactome.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	81	R-HSA-9647999	RCE1 cleaves S-Farn proRAS proteins	yes	reactome/R-HSA-9647999.md	RCE1 cleaves S-Farn proRAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ER membrane annotations reflect CAAX processing and maturation reactions for farnesylated RAS proteins in Reactome.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	82	R-HSA-9649732	Mature S-Farn-Me KRAS4B translocates to plasma membrane	yes	reactome/R-HSA-9649732.md	Mature S-Farn-Me KRAS4B translocates to plasma membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ER membrane annotations reflect CAAX processing and maturation reactions for farnesylated RAS proteins in Reactome.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	83	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KRAS has a cytoplasmic/cytosolic pool during its membrane-trafficking cycle, including PDEdelta-mediated solubilization of farnesylated KRAS.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	84	R-HSA-9647980	mature RAS proteins translocate to plasma membrane	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane localization is relevant to RAS membrane trafficking and palmitoylation cycles, especially for the K-Ras4A isoform.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	85	R-HSA-9647982	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane localization is relevant to RAS membrane trafficking and palmitoylation cycles, especially for the K-Ras4A isoform.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	86	R-HSA-1168636	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP	yes	reactome/R-HSA-1168636.md	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	87	R-HSA-1225951	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	88	R-HSA-1225957	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	89	R-HSA-1250383	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	yes	reactome/R-HSA-1250383.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	90	R-HSA-1306972	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306972.md	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	91	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	92	R-HSA-170986	Ral-GDS binds to Ras-GTP	yes	reactome/R-HSA-170986.md	Ral-GDS binds to Ras-GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	93	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	94	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	95	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	96	R-HSA-210977	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	97	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	98	R-HSA-2424477	SOS mediated nucleotide exchange of RAS (SHC)	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	99	R-HSA-392054	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	100	R-HSA-5218845	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	101	R-HSA-5621573	CD209 activate GTPase RAS	yes	reactome/R-HSA-5621573.md	CD209 activate GTPase RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	102	R-HSA-5624486	SFKs phosphorylates RAF1 on Y340,Y341	yes	reactome/R-HSA-5624486.md	SFKs phosphorylates RAF1 on Y340,Y341	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	103	R-HSA-5624492	PAK phosphorylates p21 RAF1 on S338	yes	reactome/R-HSA-5624492.md	PAK phosphorylates p21 RAF1 on S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	104	R-HSA-5624494	RAF1 binds p21 RAS:GTP	yes	reactome/R-HSA-5624494.md	RAF1 binds p21 RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	105	R-HSA-5637806	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	106	R-HSA-5637808	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	107	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	108	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	109	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	110	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	111	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	112	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	113	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	114	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	115	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	116	R-HSA-5655277	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	117	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	118	R-HSA-5655347	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655347.md	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	119	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	120	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	121	R-HSA-5672950	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	yes	reactome/R-HSA-5672950.md	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	122	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	123	R-HSA-5672966	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	yes	reactome/R-HSA-5672966.md	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	124	R-HSA-5672969	Phosphorylation of RAF	yes	reactome/R-HSA-5672969.md	Phosphorylation of RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	125	R-HSA-5672972	MAP2Ks and MAPKs bind to the activated RAF complex	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	126	R-HSA-5672973	MAP2Ks phosphorylate MAPKs	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	127	R-HSA-5672978	RAF phosphorylates MAP2K dimer	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	128	R-HSA-5672980	Dissociation of RAS:RAF complex	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	129	R-HSA-5674018	BRAP binds RAS:GTP	yes	reactome/R-HSA-5674018.md	BRAP binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	130	R-HSA-5674022	BRAP autoubiquitinates	yes	reactome/R-HSA-5674022.md	BRAP autoubiquitinates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	131	R-HSA-5675417	PEBP1 binds activated RAF1	yes	reactome/R-HSA-5675417.md	PEBP1 binds activated RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	132	R-HSA-5675431	PP2A dephosphorylates RAF1	yes	reactome/R-HSA-5675431.md	PP2A dephosphorylates RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	133	R-HSA-5675433	PP5 dephosphorylates RAF1 S338	yes	reactome/R-HSA-5675433.md	PP5 dephosphorylates RAF1 S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	134	R-HSA-6802837	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	yes	reactome/R-HSA-6802837.md	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	135	R-HSA-8851827	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	yes	reactome/R-HSA-8851827.md	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	136	R-HSA-8851877	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	yes	reactome/R-HSA-8851877.md	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	137	R-HSA-8851899	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	yes	reactome/R-HSA-8851899.md	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	138	R-HSA-8941613	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941613.md	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	139	R-HSA-8941618	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941618.md	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	140	R-HSA-8941623	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941623.md	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	141	R-HSA-8941628	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941628.md	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	142	R-HSA-8981353	RASA1 stimulates RAS GTPase activity	yes	reactome/R-HSA-8981353.md	RASA1 stimulates RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	143	R-HSA-8981355	RASA1 binds RAS:GTP	yes	reactome/R-HSA-8981355.md	RASA1 binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	144	R-HSA-9607304	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	145	R-HSA-9632906	PRKCZ recruits RAS in response to estrogen stimulation	yes	reactome/R-HSA-9632906.md	PRKCZ recruits RAS in response to estrogen stimulation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	146	R-HSA-9632918	PRKCZ stimulates RAS nucleotide exchange in response to estrogen	yes	reactome/R-HSA-9632918.md	PRKCZ stimulates RAS nucleotide exchange in response to estrogen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	147	R-HSA-9634418	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	yes	reactome/R-HSA-9634418.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	148	R-HSA-9647980	mature RAS proteins translocate to plasma membrane	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	149	R-HSA-9647994	RAS proteins are depalmitoylated	yes	reactome/R-HSA-9647994.md	RAS proteins are depalmitoylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	150	R-HSA-9649733	mature p21 RAS binds GDP	yes	reactome/R-HSA-9649733.md	mature p21 RAS binds GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	151	R-HSA-9649735	Intrinsic nucleotide exchange on RAS	yes	reactome/R-HSA-9649735.md	Intrinsic nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	152	R-HSA-9649736	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	153	R-HSA-9653108	Raf dimer inhibitors bind RAF heterodimers	yes	reactome/R-HSA-9653108.md	Raf dimer inhibitors bind RAF heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	154	R-HSA-9656209	Dissociation of RAS:RAF1 mutant complex	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	155	R-HSA-9656211	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	156	R-HSA-9656212	Phosphorylation of RAF1 mutants	yes	reactome/R-HSA-9656212.md	Phosphorylation of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	157	R-HSA-9656213	RAF1 mutants show enhanced heterodimerization with BRAF	yes	reactome/R-HSA-9656213.md	RAF1 mutants show enhanced heterodimerization with BRAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	158	R-HSA-9656214	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	159	R-HSA-9656215	RAF1 mutant complexes phosphorylate MAP2K dimer	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	160	R-HSA-9657599	Dual mechanism MAP2K inhibitors bind MAP2Ks	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	161	R-HSA-9657603	Dual mechanism MAPK inhibitors bind MAPKs	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	162	R-HSA-9657606	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	163	R-HSA-9657608	Single mechanism MAPK inhibitors bind phosphorylated MAPK	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	164	R-HSA-9658253	RAS:GTP binds PI3K	yes	reactome/R-HSA-9658253.md	RAS:GTP binds PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	165	R-HSA-9664991	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	166	R-HSA-9665009	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	167	R-HSA-9665404	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	168	R-HSA-9665408	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	169	R-HSA-9665700	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	170	R-HSA-9665707	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	171	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	172	R-HSA-9672163	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672163.md	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	173	R-HSA-9672170	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	174	R-HSA-9695853	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	175	R-HSA-9703441	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	176	R-HSA-9647982	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ER membrane annotations reflect CAAX processing and maturation reactions for farnesylated RAS proteins in Reactome.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	177	R-HSA-9649732	Mature S-Farn-Me KRAS4B translocates to plasma membrane	yes	reactome/R-HSA-9649732.md	Mature S-Farn-Me KRAS4B translocates to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	178	R-HSA-9653585	S-Farn-Me KRAS4B binds calmodulin	yes	reactome/R-HSA-9653585.md	S-Farn-Me KRAS4B binds calmodulin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	179	R-HSA-9654521	Calmodulin dissociates KRAS4B from the plasma membrane	yes	reactome/R-HSA-9654521.md	Calmodulin dissociates KRAS4B from the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	180	R-HSA-9654533	KRAS4B recycles to the plasma membrane	yes	reactome/R-HSA-9654533.md	KRAS4B recycles to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	185	R-HSA-6802914	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	186	R-HSA-6802915	Moderate kinase activity BRAF mutants bind RAS:GTP	yes	reactome/R-HSA-6802915.md	Moderate kinase activity BRAF mutants bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	187	R-HSA-6802916	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802916.md	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	188	R-HSA-6802919	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	189	R-HSA-6802921	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	190	R-HSA-6803230	Dissociation of moderate activity BRAF complexes	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KRAS	genes/human/KRAS/KRAS-ai-review.yaml	KRAS	P01116	NCBITaxon:9606	Homo sapiens	191	R-HSA-8936676	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	yes	reactome/R-HSA-8936676.md	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane localization. KRAS is lipid-anchored and functions at the cytoplasmic face of the plasma membrane.
human	KYNU	genes/human/KYNU/KYNU-ai-review.yaml	KYNU	Q16719	NCBITaxon:9606	Homo sapiens	18	R-HSA-71217	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+	yes	reactome/R-HSA-71217.md	3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable (TAS) annotation placing the kynureninase reaction (3-hydroxykynurenine to 3-hydroxyanthranilate) in the cytosol. Matches the authoritative UniProt location. Accept as core.
human	LAMP1	genes/human/LAMP1/LAMP1-ai-review.yaml	LAMP1	P11279	NCBITaxon:9606	Homo sapiens	52	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	plasma membrane is supported during LAMP1 cycling and cytotoxic granule exocytosis, but it is secondary to the lysosomal membrane location.
human	LAMP1	genes/human/LAMP1/LAMP1-ai-review.yaml	LAMP1	P11279	NCBITaxon:9606	Homo sapiens	53	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	plasma membrane is supported during LAMP1 cycling and cytotoxic granule exocytosis, but it is secondary to the lysosomal membrane location.
human	LAMP1	genes/human/LAMP1/LAMP1-ai-review.yaml	LAMP1	P11279	NCBITaxon:9606	Homo sapiens	54	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	azurophil granule membrane is a supported lysosome-related secretory granule membrane context in immune cells.
human	LAMP1	genes/human/LAMP1/LAMP1-ai-review.yaml	LAMP1	P11279	NCBITaxon:9606	Homo sapiens	55	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ficolin-1-rich granule membrane is a supported lysosome-related secretory granule membrane context in immune cells.
human	LDHA	genes/human/LDHA/LDHA-ai-review.yaml	LDHA	P00338	NCBITaxon:9606	Homo sapiens	31	R-HSA-9861563	CTLH E3 ligase ubiquitinates LDHA	yes	reactome/R-HSA-9861563.md	CTLH E3 ligase ubiquitinates LDHA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosolic localization (from the CTLH-ligase ubiquitination reaction). Consistent with the core cytosolic location.
human	LDHA	genes/human/LDHA/LDHA-ai-review.yaml	LDHA	P00338	NCBITaxon:9606	Homo sapiens	43	R-HSA-70510	LDH tetramer oxidises LACT to PYR	yes	reactome/R-HSA-70510.md	LDH tetramer oxidises LACT to PYR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosolic localization (LDH tetramer oxidises lactate to pyruvate reaction). Consistent with core cytosolic location.
human	LDHA	genes/human/LDHA/LDHA-ai-review.yaml	LDHA	P00338	NCBITaxon:9606	Homo sapiens	44	R-HSA-71849	LDH tetramer reduces PYR to LACT	yes	reactome/R-HSA-71849.md	LDH tetramer reduces PYR to LACT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosolic localization (LDH tetramer reduces pyruvate to lactate reaction). Consistent with core cytosolic location.
human	LDHB	genes/human/LDHB/LDHB-ai-review.yaml	LDHB	P07195	NCBITaxon:9606	Homo sapiens	45	R-HSA-70510	LDH tetramer oxidises LACT to PYR	yes	reactome/R-HSA-70510.md	LDH tetramer oxidises LACT to PYR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing LDHB in the cytosol in the context of LDH tetramer oxidises LACT to PYR, the lactate-oxidising direction favoured by the LDHB-rich isoenzyme.
human	LDHB	genes/human/LDHB/LDHB-ai-review.yaml	LDHB	P07195	NCBITaxon:9606	Homo sapiens	46	R-HSA-71849	LDH tetramer reduces PYR to LACT	yes	reactome/R-HSA-71849.md	LDH tetramer reduces PYR to LACT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing LDHB in the cytosol in the context of LDH tetramer reduces PYR to LACT.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	25	R-HSA-9668335	CHMP7 binds LEMD2	yes	reactome/R-HSA-9668335.md	CHMP7 binds LEMD2	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	26	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	27	R-HSA-9668395	CHMP7 binds CC2D1B	yes	reactome/R-HSA-9668395.md	CHMP7 binds CC2D1B	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	28	R-HSA-9668398	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	yes	reactome/R-HSA-9668398.md	CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	29	R-HSA-9668405	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	yes	reactome/R-HSA-9668405.md	SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	30	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LEMD2	genes/human/LEMD2/LEMD2-ai-review.yaml	LEMD2	Q8NC56	NCBITaxon:9606	Homo sapiens	31	R-HSA-9668419	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	yes	reactome/R-HSA-9668419.md	SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Nuclear envelope - core localization.
human	LGALS3	genes/human/LGALS3/LGALS3-ai-review.yaml	LGALS3	P17931	NCBITaxon:9606	Homo sapiens	62	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places galectin-3 at the secretory (specific) granule membrane in the context of neutrophil degranulation. Consistent with packaging for secretion in neutrophils; specialized cell-type context.
human	LGALS3	genes/human/LGALS3/LGALS3-ai-review.yaml	LGALS3	P17931	NCBITaxon:9606	Homo sapiens	63	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places galectin-3 at the ficolin-1-rich granule membrane in neutrophil degranulation. Specialized cell-type context.
human	LGALS3	genes/human/LGALS3/LGALS3-ai-review.yaml	LGALS3	P17931	NCBITaxon:9606	Homo sapiens	97	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places galectin-3 at the plasma membrane in the neutrophil-degranulation pathway. Consistent with cell-surface association after secretion.
human	LGALS3	genes/human/LGALS3/LGALS3-ai-review.yaml	LGALS3	P17931	NCBITaxon:9606	Homo sapiens	98	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation (ficolin-rich granule pathway). Consistent with cell-surface association.
human	LGALS3	genes/human/LGALS3/LGALS3-ai-review.yaml	LGALS3	P17931	NCBITaxon:9606	Homo sapiens	99	R-HSA-8938382	LGALS3 gene expression is stimulated by RUNX1 and RUNX2	yes	reactome/R-HSA-8938382.md	LGALS3 gene expression is stimulated by RUNX1 and RUNX2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation (RUNX-regulated expression pathway). Consistent with cell-surface association after secretion.
human	LIMD1	genes/human/LIMD1/LIMD1-ai-review.yaml	LIMD1	Q9UGP4	NCBITaxon:9606	Homo sapiens	30	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for LIMD1 scaffold function across junctional, cytoplasmic/P-body, and nuclear compartments.
human	LIMD1	genes/human/LIMD1/LIMD1-ai-review.yaml	LIMD1	Q9UGP4	NCBITaxon:9606	Homo sapiens	31	R-HSA-1234163	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234163.md	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for LIMD1 scaffold function across junctional, cytoplasmic/P-body, and nuclear compartments.
human	LIMD1	genes/human/LIMD1/LIMD1-ai-review.yaml	LIMD1	Q9UGP4	NCBITaxon:9606	Homo sapiens	32	R-HSA-1234173	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	yes	reactome/R-HSA-1234173.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for LIMD1 scaffold function across junctional, cytoplasmic/P-body, and nuclear compartments.
human	LIMD1	genes/human/LIMD1/LIMD1-ai-review.yaml	LIMD1	Q9UGP4	NCBITaxon:9606	Homo sapiens	33	R-HSA-1234177	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	yes	reactome/R-HSA-1234177.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for LIMD1 scaffold function across junctional, cytoplasmic/P-body, and nuclear compartments.
human	LIMD1	genes/human/LIMD1/LIMD1-ai-review.yaml	LIMD1	Q9UGP4	NCBITaxon:9606	Homo sapiens	34	R-HSA-1234183	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234183.md	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is supported for LIMD1 scaffold function across junctional, cytoplasmic/P-body, and nuclear compartments.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	38	R-HSA-5694446	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	yes	reactome/R-HSA-5694446.md	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERGIC membrane localization in the COPII transport pathway.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	39	R-HSA-203973	Vesicle budding	yes	reactome/R-HSA-203973.md	Vesicle budding	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization during vesicle budding.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	40	R-HSA-204008	SEC31:SEC13 and v-SNARE recruitment	yes	reactome/R-HSA-204008.md	SEC31:SEC13 and v-SNARE recruitment	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization during COPII coat recruitment.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	41	R-HSA-5694417	SEC16 complex binds SAR1B:GTP:SEC23:SEC24	yes	reactome/R-HSA-5694417.md	SEC16 complex binds SAR1B:GTP:SEC23:SEC24	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization during COPII inner-coat assembly.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	42	R-HSA-5694428	LMAN family proteins bind glycosylated cargo	yes	reactome/R-HSA-5694428.md	LMAN family proteins bind glycosylated cargo	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation (LMAN family proteins bind glycosylated cargo) placing ERGIC-53 at the ER membrane.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	43	R-HSA-5694431	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors	yes	reactome/R-HSA-5694431.md	Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation (hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors) placing ERGIC-53 at the ER membrane.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	44	R-HSA-5694522	Inner coat assembly and cargo binding	yes	reactome/R-HSA-5694522.md	Inner coat assembly and cargo binding	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization during inner coat assembly and cargo binding.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	45	R-HSA-5694527	Loss of SAR1B GTPase	yes	reactome/R-HSA-5694527.md	Loss of SAR1B GTPase	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization during COPII budding (loss of SAR1B GTPase).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	49	R-HSA-203973	Vesicle budding	yes	reactome/R-HSA-203973.md	Vesicle budding	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane during vesicle budding.
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	50	R-HSA-5694409	Nucleotide exchange on RAB1	yes	reactome/R-HSA-5694409.md	Nucleotide exchange on RAB1	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane (nucleotide exchange on RAB1).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	51	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane (RAB1 tethering).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	52	R-HSA-5694439	COPII coat binds TRAPPCII and RAB1:GDP	yes	reactome/R-HSA-5694439.md	COPII coat binds TRAPPCII and RAB1:GDP	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane (COPII binds TRAPPCII and RAB1).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	53	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane (CSNK1D phosphorylates SEC23).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	54	R-HSA-5694446	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	yes	reactome/R-HSA-5694446.md	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation placing ERGIC-53 in the ER-to-Golgi transport vesicle membrane (v-SNARE binding on tethered vesicle).
human	LMAN1	genes/human/LMAN1/LMAN1-ai-review.yaml	LMAN1	P49257	NCBITaxon:9606	Homo sapiens	55	R-HSA-947991	Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi	yes	reactome/R-HSA-947991.md	Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation (Transport of glycoproteins with Man8/Man9 N-glycans to the Golgi) placing ERGIC-53 in the transport vesicle membrane; directly reflects its high-mannose lectin cargo function.
human	LMBRD1	genes/human/LMBRD1/LMBRD1-ai-review.yaml	LMBRD1	Q9NUN5	NCBITaxon:9606	Homo sapiens	37	R-HSA-5223313	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)	yes	reactome/R-HSA-5223313.md	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol (gut mucosal cells)	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS lysosomal membrane localization from the ABCD4:LMBRD1 cobalamin export reaction (gut mucosal cells). Consistent with the core location.
human	LMBRD1	genes/human/LMBRD1/LMBRD1-ai-review.yaml	LMBRD1	Q9NUN5	NCBITaxon:9606	Homo sapiens	38	R-HSA-5683325	Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol	yes	reactome/R-HSA-5683325.md	Defective ABCD4:LMBRD1 does not transport Cbl from lysosomal lumen to cytosol	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS lysosomal membrane localization from the defective ABCD4:LMBRD1 cobalamin transport reaction. Consistent with the core location.
human	LMBRD1	genes/human/LMBRD1/LMBRD1-ai-review.yaml	LMBRD1	Q9NUN5	NCBITaxon:9606	Homo sapiens	39	R-HSA-9759206	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol	yes	reactome/R-HSA-9759206.md	ABCD4:LMBRD1 transports RCbl from lysosomal lumen to cytosol	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS lysosomal membrane localization from the ABCD4:LMBRD1 cobalamin export reaction (cells throughout the body). Consistent with the core location.
human	LNPEP	genes/human/LNPEP/LNPEP-ai-review.yaml	LNPEP	Q9UIQ6	NCBITaxon:9606	Homo sapiens	22	R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	yes	reactome/R-HSA-983168.md	Antigen processing: Ubiquitination & Proteasome degradation	Homo sapiens	GO:0000209	protein polyubiquitination	TAS	involved_in	BP	false		REMOVE	LNPEP is not part of the ubiquitin-conjugation machinery in this Reactome pathway.
human	LNPEP	genes/human/LNPEP/LNPEP-ai-review.yaml	LNPEP	Q9UIQ6	NCBITaxon:9606	Homo sapiens	23	R-HSA-1236977	Endosomal/Vacuolar pathway	yes	reactome/R-HSA-1236977.md	Endosomal/Vacuolar pathway	Homo sapiens	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS	involved_in	BP	false		MODIFY	LNPEP supports exogenous-antigen cross-presentation, but TAP independence is not established and the demonstrated route requires proteasomes.
human	LNPEP	genes/human/LNPEP/LNPEP-ai-review.yaml	LNPEP	Q9UIQ6	NCBITaxon:9606	Homo sapiens	33	R-HSA-983162	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases	yes	reactome/R-HSA-983162.md	Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Full-length LNPEP is not a soluble cytosolic aminopeptidase.
human	LNPEP	genes/human/LNPEP/LNPEP-ai-review.yaml	LNPEP	Q9UIQ6	NCBITaxon:9606	Homo sapiens	34	R-HSA-1236954	Trimming of peptides by IRAP in endocytic vesicles	yes	reactome/R-HSA-1236954.md	Trimming of peptides by IRAP in endocytic vesicles	Homo sapiens	GO:0031905	early endosome lumen	TAS	located_in	CC	false		MODIFY	LNPEP occupies the early-endosome membrane, with its catalytic domain exposed to the lumen; the whole protein is not a lumenal component.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	30	R-HSA-9837999	Mitochondrial protein degradation	yes	reactome/R-HSA-9837999.md	Mitochondrial protein degradation	Homo sapiens	GO:0035694	mitochondrial protein catabolic process	TAS	involved_in	BP	false		ACCEPT	Core mitochondrial substrate-degradation process represented in Reactome.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	41	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0004176	ATP-dependent peptidase activity	TAS	enables	MF	false		ACCEPT	Correct core catalytic activity in a Reactome substrate-degradation reaction.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	42	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0004176	ATP-dependent peptidase activity	TAS	enables	MF	false		ACCEPT	Correct core catalytic activity in a Reactome matrix-protein degradation reaction.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	43	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix localization for the Reactome substrate-binding reaction.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	44	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix localization for LONP1-mediated degradation.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	45	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix localization for the Reactome matrix-protein degradation reaction.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	46	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct matrix localization for substrate engagement by LONP1.
human	LONP1	genes/human/LONP1/LONP1-ai-review.yaml	LONP1	P36776	NCBITaxon:9606	Homo sapiens	47	R-HSA-9856668	ATF5 activates expression of LONP1	yes	reactome/R-HSA-9856668.md	ATF5 activates expression of LONP1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct localization of the LONP1 gene product in a Reactome transcriptional-regulation event.
human	LONP2	genes/human/LONP2/LONP2-ai-review.yaml	LONP2	Q86WA8	NCBITaxon:9606	Homo sapiens	25	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation for peroxisomal matrix from Reactome pathway annotation. Reactome pathway R-HSA-9033235 is ""Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix""."
human	LONP2	genes/human/LONP2/LONP2-ai-review.yaml	LONP2	Q86WA8	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome. This reflects the cytosolic location of newly synthesized LONP2 before import into peroxisomes.
human	LONP2	genes/human/LONP2/LONP2-ai-review.yaml	LONP2	Q86WA8	NCBITaxon:9606	Homo sapiens	27	R-HSA-9033236	PEX5S,L Cargo binds PEX13-PEX14-PEX2-PEX10-PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation for cytosol from Reactome pathway R-HSA-9033236 ""PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)""."
human	LONRF1	genes/human/LONRF1/LONRF1-ai-review.yaml	LONRF1	Q17RB8	NCBITaxon:9606	Homo sapiens	8	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome places LONRF1 in the cytosolic step transferring ubiquitin from an E2 to an E3-bound substrate.
human	LONRF1	genes/human/LONRF1/LONRF1-ai-review.yaml	LONRF1	Q17RB8	NCBITaxon:9606	Homo sapiens	9	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome places LONRF1 in the cytosolic release of an E3 from its polyubiquitinated substrate.
human	LONRF1	genes/human/LONRF1/LONRF1-ai-review.yaml	LONRF1	Q17RB8	NCBITaxon:9606	Homo sapiens	10	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome places LONRF1 in a cytosolic substrate-polyubiquitination step.
human	LONRF1	genes/human/LONRF1/LONRF1-ai-review.yaml	LONRF1	Q17RB8	NCBITaxon:9606	Homo sapiens	11	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome places LONRF1 in the cytosolic interaction of an E3 with substrate and an E2-ubiquitin complex.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	9	R-HSA-6814764	Plasma membrane resorption	yes	reactome/R-HSA-6814764.md	Plasma membrane resorption	Homo sapiens	GO:0001533	cornified envelope	TAS	located_in	CC	false		ACCEPT	Reactome places loricrin in the cornified envelope during plasma-membrane resorption in terminally differentiating keratinocytes.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	10	R-HSA-6810937	Lamellar bodies bind the early cornified envelope	yes	reactome/R-HSA-6810937.md	Lamellar bodies bind the early cornified envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic loricrin in the lamellar-body/early-envelope stage of cornified-envelope formation.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	11	R-HSA-6811539	Reinforcement of the Cornified Envelope	yes	reactome/R-HSA-6811539.md	Reinforcement of the Cornified Envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic loricrin during reinforcement of the cornified envelope.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	12	R-HSA-6814298	Late envelope proteins bind cornified envelope:CDSN	yes	reactome/R-HSA-6814298.md	Late envelope proteins bind cornified envelope:CDSN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns loricrin to the cytosol in a late-envelope-protein binding event within cornified-envelope formation.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	13	R-HSA-6814387	CASP14 cleaves filaggrin	yes	reactome/R-HSA-6814387.md	CASP14 cleaves filaggrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic loricrin in the cornification event describing CASP14-dependent filaggrin cleavage.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	14	R-HSA-6814734	CDSN binds the cornified envelope	yes	reactome/R-HSA-6814734.md	CDSN binds the cornified envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns cytosolic loricrin in the event linking corneodesmosin to the cornified envelope.
human	LORICRIN	genes/human/LORICRIN/LORICRIN-ai-review.yaml	LORICRIN	P23490	NCBITaxon:9606	Homo sapiens	15	R-HSA-6814764	Plasma membrane resorption	yes	reactome/R-HSA-6814764.md	Plasma membrane resorption	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns a cytosolic pool of loricrin during plasma-membrane resorption in differentiating keratinocytes.
human	LOX	genes/human/LOX/LOX-ai-review.yaml	LOX	P28300	NCBITaxon:9606	Homo sapiens	38	R-HSA-2022141	Prolysyl oxidase activation	yes	reactome/R-HSA-2022141.md	Prolysyl oxidase activation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places proLOX activation in the extracellular space.
human	LOX	genes/human/LOX/LOX-ai-review.yaml	LOX	P28300	NCBITaxon:9606	Homo sapiens	39	R-HSA-2002466	Formation of allysine by LOX	yes	reactome/R-HSA-2002466.md	Formation of allysine by LOX	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome correctly places LOX-catalyzed collagen lysine oxidation extracellularly.
human	LOX	genes/human/LOX/LOX-ai-review.yaml	LOX	P28300	NCBITaxon:9606	Homo sapiens	40	R-HSA-2129375	Elastin cross-linking by lysyl oxidase	yes	reactome/R-HSA-2129375.md	Elastin cross-linking by lysyl oxidase	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome correctly places LOX-catalyzed tropoelastin oxidation and cross-link initiation extracellularly.
human	LOX	genes/human/LOX/LOX-ai-review.yaml	LOX	P28300	NCBITaxon:9606	Homo sapiens	41	R-HSA-2395340	Formation of hydroxyallysine by LOX	yes	reactome/R-HSA-2395340.md	Formation of hydroxyallysine by LOX	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome correctly places hydroxylysine-to-hydroxyallysine conversion by LOX in extracellular collagen.
human	LOXL1	genes/human/LOXL1/LOXL1-ai-review.yaml	LOXL1	Q08397	NCBITaxon:9606	Homo sapiens	16	R-HSA-2022141	Prolysyl oxidase activation	yes	reactome/R-HSA-2022141.md	Prolysyl oxidase activation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	A Reactome-derived TAS row assigns LOXL1 to the extracellular region during prolysyl-oxidase activation.
human	LOXL1	genes/human/LOXL1/LOXL1-ai-review.yaml	LOXL1	Q08397	NCBITaxon:9606	Homo sapiens	24	R-HSA-2002466	Formation of allysine by LOX	yes	reactome/R-HSA-2002466.md	Formation of allysine by LOX	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	A Reactome-derived TAS row assigns LOXL1 to the extracellular region during collagen lysine oxidation.
human	LOXL1	genes/human/LOXL1/LOXL1-ai-review.yaml	LOXL1	Q08397	NCBITaxon:9606	Homo sapiens	25	R-HSA-2129375	Elastin cross-linking by lysyl oxidase	yes	reactome/R-HSA-2129375.md	Elastin cross-linking by lysyl oxidase	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	A Reactome-derived TAS row assigns LOXL1 to the extracellular region during elastin cross-linking.
human	LOXL1	genes/human/LOXL1/LOXL1-ai-review.yaml	LOXL1	Q08397	NCBITaxon:9606	Homo sapiens	26	R-HSA-2395340	Formation of hydroxyallysine by LOX	yes	reactome/R-HSA-2395340.md	Formation of hydroxyallysine by LOX	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	A Reactome-derived TAS row assigns LOXL1 to the extracellular region during collagen hydroxylysine oxidation.
human	LPA	genes/human/LPA/LPA-ai-review.yaml	LPA	P08519	NCBITaxon:9606	Homo sapiens	6	R-HSA-176879	apolipoprotein(a) + LDL => Lp(a)	yes	reactome/R-HSA-176879.md	apolipoprotein(a) + LDL => Lp(a)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted as the core compartment of secreted apo(a) and extracellular Lp(a) particle assembly.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	65	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	66	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	67	R-HSA-419389	LPA-binding receptors bind LPA	yes	reactome/R-HSA-419389.md	LPA-binding receptors bind LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	68	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	69	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	70	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR1	genes/human/LPAR1/LPAR1-ai-review.yaml	LPAR1	Q92633	NCBITaxon:9606	Homo sapiens	71	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as a core component of LPAR1 ligand recognition, membrane localization, or proximal G-protein signaling: plasma membrane.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	22	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	23	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	24	R-HSA-419389	LPA-binding receptors bind LPA	yes	reactome/R-HSA-419389.md	LPA-binding receptors bind LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	25	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	26	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	27	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR2	genes/human/LPAR2/LPAR2-ai-review.yaml	LPAR2	Q9HBW0	NCBITaxon:9606	Homo sapiens	28	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR2 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	20	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	21	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	22	R-HSA-419389	LPA-binding receptors bind LPA	yes	reactome/R-HSA-419389.md	LPA-binding receptors bind LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	23	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	24	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	25	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR3	genes/human/LPAR3/LPAR3-ai-review.yaml	LPAR3	Q9UBY5	NCBITaxon:9606	Homo sapiens	26	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal LPAR3 signaling.
human	LPAR4	genes/human/LPAR4/LPAR4-ai-review.yaml	LPAR4	Q99677	NCBITaxon:9606	Homo sapiens	12	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal Gq/11 signaling.
human	LPAR4	genes/human/LPAR4/LPAR4-ai-review.yaml	LPAR4	Q99677	NCBITaxon:9606	Homo sapiens	13	R-HSA-417820	P2Y9 receptor can bind to LPA	yes	reactome/R-HSA-417820.md	P2Y9 receptor can bind to LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location of the curated LPAR4 ligand-binding event.
human	LPAR4	genes/human/LPAR4/LPAR4-ai-review.yaml	LPAR4	Q99677	NCBITaxon:9606	Homo sapiens	14	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated Gq binding.
human	LPAR4	genes/human/LPAR4/LPAR4-ai-review.yaml	LPAR4	Q99677	NCBITaxon:9606	Homo sapiens	15	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in the curated Gq activation cycle.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	6	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal Gq/11 signaling.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	7	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal Gi signaling.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	8	R-HSA-419389	LPA-binding receptors bind LPA	yes	reactome/R-HSA-419389.md	LPA-binding receptors bind LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location of the curated LPA-binding receptor event.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	9	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated Gq binding.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	10	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in the curated Gq activation cycle.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	11	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in the curated Gi activation cycle.
human	LPAR5	genes/human/LPAR5/LPAR5-ai-review.yaml	LPAR5	Q9H1C0	NCBITaxon:9606	Homo sapiens	12	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated Gi binding.
human	LPAR6	genes/human/LPAR6/LPAR6-ai-review.yaml	LPAR6	P43657	NCBITaxon:9606	Homo sapiens	11	R-HSA-379048	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	yes	reactome/R-HSA-379048.md	Liganded Gq/11-activating GPCRs act as GEFs for Gq/11	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location used in curated proximal Gq/11 signaling.
human	LPAR6	genes/human/LPAR6/LPAR6-ai-review.yaml	LPAR6	P43657	NCBITaxon:9606	Homo sapiens	12	R-HSA-417890	P2Y5 receptor can bind to LPA	yes	reactome/R-HSA-417890.md	P2Y5 receptor can bind to LPA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location of the LPA-binding receptor event.
human	LPAR6	genes/human/LPAR6/LPAR6-ai-review.yaml	LPAR6	P43657	NCBITaxon:9606	Homo sapiens	13	R-HSA-749448	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	yes	reactome/R-HSA-749448.md	Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location of the curated receptor-Gq association step.
human	LPAR6	genes/human/LPAR6/LPAR6-ai-review.yaml	LPAR6	P43657	NCBITaxon:9606	Homo sapiens	14	R-HSA-749452	The Ligand:GPCR:Gq complex dissociates	yes	reactome/R-HSA-749452.md	The Ligand:GPCR:Gq complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the plasma-membrane location of the curated receptor-Gq dissociation step.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	8	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	TAS annotation from Reactome for LPGAT activity (1-acyl LPG to PG). This represents LPCAT1's activity on lysophosphatidylglycerol.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	9	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	TAS annotation from Reactome pathway for 1-acyl LPC acylation to PC.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	10	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	TAS annotation for PA synthesis (1-acyl LPA to PA). Part of the Reactome phospholipid biosynthesis pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	12	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	TAS annotation for 2-acyl LPC acylation to PC. This represents activity on 2-acyl-substituted lysophospholipids, which are less common than 1-acyl species.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	13	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	TAS annotation for 2-acyl LPG acylation to PG.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	30	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for PC synthesis.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	31	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	32	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	33	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	34	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	35	R-HSA-8873834	STARD10 transports PC from ER membrane to lamellar body membrane	yes	reactome/R-HSA-8873834.md	STARD10 transports PC from ER membrane to lamellar body membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for STARD10 transport of PC from ER membrane.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	36	R-HSA-8873923	STARD10 binds LPCAT1 and PC	yes	reactome/R-HSA-8873923.md	STARD10 binds LPCAT1 and PC	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for STARD10-LPCAT1-PC complex.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	44	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome for exocytosis of azurophil granule membrane proteins. This represents LPCAT1 presence at the plasma membrane during neutrophil degranulation.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	45	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome indicating LPCAT1 presence in azurophil granule membrane during neutrophil degranulation.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	49	R-HSA-1482788	Acyl chain remodelling of PC	yes	reactome/R-HSA-1482788.md	Acyl chain remodelling of PC	Homo sapiens	GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	TAS annotation from Reactome for PC acyl-chain remodeling pathway.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	50	R-HSA-1482925	Acyl chain remodelling of PG	yes	reactome/R-HSA-1482925.md	Acyl chain remodelling of PG	Homo sapiens	GO:0036148	phosphatidylglycerol acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	TAS annotation for PG acyl-chain remodeling from Reactome. LPCAT1 can act on lysophosphatidylglycerol as an alternative substrate.
human	LPCAT1	genes/human/LPCAT1/LPCAT1-ai-review.yaml	LPCAT1	Q8NF37	NCBITaxon:9606	Homo sapiens	51	R-HSA-1483166	Synthesis of PA	yes	reactome/R-HSA-1483166.md	Synthesis of PA	Homo sapiens	GO:0006654	phosphatidic acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	TAS annotation for PA biosynthesis from Reactome. LPCAT1 can convert LPA to PA.
human	LPCAT2	genes/human/LPCAT2/LPCAT2-ai-review.yaml	LPCAT2	Q7L5N7	NCBITaxon:9606	Homo sapiens	11	R-HSA-1482788	Acyl chain remodelling of PC	yes	reactome/R-HSA-1482788.md	Acyl chain remodelling of PC	Homo sapiens	GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for PC acyl chain remodeling is consistent with LPCAT2's role in the Lands cycle.
human	LPCAT2	genes/human/LPCAT2/LPCAT2-ai-review.yaml	LPCAT2	Q7L5N7	NCBITaxon:9606	Homo sapiens	12	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation for AGPAT activity is consistent with experimental evidence demonstrating LPCAT2's ability to acylate LPA at sn-1.
human	LPCAT2	genes/human/LPCAT2/LPCAT2-ai-review.yaml	LPCAT2	Q7L5N7	NCBITaxon:9606	Homo sapiens	13	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	This annotation suggests LPCAT2 can acylate 2-acyl-sn-glycero-3-phosphate (sn-1 acylation). While LPCAT2 primarily acylates at sn-2 position, this represents a less well-characterized activity.
human	LPCAT2	genes/human/LPCAT2/LPCAT2-ai-review.yaml	LPCAT2	Q7L5N7	NCBITaxon:9606	Homo sapiens	14	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization is consistent with experimental evidence.
human	LPCAT2	genes/human/LPCAT2/LPCAT2-ai-review.yaml	LPCAT2	Q7L5N7	NCBITaxon:9606	Homo sapiens	15	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate ER membrane annotation from different Reactome reaction.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	16	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Reactome annotation for AGPAT-like activity. However, LPCAT3 acts on lysophospholipids (with headgroups like choline, ethanolamine, serine), not on lysophosphatidic acid (LPA). This activity is distinct from true AGPAT/LPAAT activity.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	17	R-HSA-1482636	1-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482636.md	1-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Second Reactome annotation for AGPAT activity.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	18	R-HSA-1482667	1-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482667.md	1-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Third Reactome annotation for AGPAT activity.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	19	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Reactome annotation for acyltransferase activity at the sn-1 position of 2-acyl-lysophospholipids.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	20	R-HSA-1482646	2-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482646.md	2-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Second Reactome annotation for 2-AGPAT activity.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	21	R-HSA-1482691	2-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482691.md	2-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		UNDECIDED	Third Reactome annotation for 2-AGPAT activity.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	27	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization in context of PC acyl chain remodeling pathway.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	28	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	29	R-HSA-1482636	1-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482636.md	1-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	30	R-HSA-1482646	2-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482646.md	2-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	31	R-HSA-1482667	1-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482667.md	1-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	32	R-HSA-1482691	2-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482691.md	2-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ER membrane localization.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	36	R-HSA-1482839	Acyl chain remodelling of PE	yes	reactome/R-HSA-1482839.md	Acyl chain remodelling of PE	Homo sapiens	GO:0036152	phosphatidylethanolamine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for PE acyl-chain remodeling.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	42	R-HSA-1482788	Acyl chain remodelling of PC	yes	reactome/R-HSA-1482788.md	Acyl chain remodelling of PC	Homo sapiens	GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for PC acyl-chain remodeling.
human	LPCAT3	genes/human/LPCAT3/LPCAT3-ai-review.yaml	LPCAT3	Q6P1A2	NCBITaxon:9606	Homo sapiens	48	R-HSA-1482801	Acyl chain remodelling of PS	yes	reactome/R-HSA-1482801.md	Acyl chain remodelling of PS	Homo sapiens	GO:0036150	phosphatidylserine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for PS acyl-chain remodeling.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	17	R-HSA-1483166	Synthesis of PA	yes	reactome/R-HSA-1483166.md	Synthesis of PA	Homo sapiens	GO:0006654	phosphatidic acid biosynthetic process	TAS	involved_in	BP	false		REMOVE	The phosphatidic-acid biosynthesis assignment is contradicted by direct LPCAT4 substrate testing.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	18	R-HSA-1482925	Acyl chain remodelling of PG	yes	reactome/R-HSA-1482925.md	Acyl chain remodelling of PG	Homo sapiens	GO:0036148	phosphatidylglycerol acyl-chain remodeling	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Phosphatidylglycerol remodeling is retained as a position-dependent, non-core activity.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	19	R-HSA-1482801	Acyl chain remodelling of PS	yes	reactome/R-HSA-1482801.md	Acyl chain remodelling of PS	Homo sapiens	GO:0036150	phosphatidylserine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Accepted as phosphatidylserine acyl-chain remodeling by an ER lysophospholipid acyltransferase.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	20	R-HSA-1482788	Acyl chain remodelling of PC	yes	reactome/R-HSA-1482788.md	Acyl chain remodelling of PC	Homo sapiens	GO:0036151	phosphatidylcholine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Accepted as phosphatidylcholine acyl-chain remodeling by an ER lysophospholipid acyltransferase.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	21	R-HSA-1482839	Acyl chain remodelling of PE	yes	reactome/R-HSA-1482839.md	Acyl chain remodelling of PE	Homo sapiens	GO:0036152	phosphatidylethanolamine acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Accepted as phosphatidylethanolamine acyl-chain remodeling by an ER lysophospholipid acyltransferase.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	23	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 1-acyl LPG acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	24	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 1-acyl LPC acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	25	R-HSA-1482636	1-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482636.md	1-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 1-acyl LPS acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	26	R-HSA-1482667	1-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482667.md	1-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 1-acyl LPE acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	27	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		REMOVE	The Reactome LPA-to-PA activity is contradicted by direct human LPCAT4 biochemistry.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	28	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 2-acyl LPC acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	29	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		REMOVE	The 2-acyl LPG reaction is contradicted by position-resolved LPCAT4 substrate testing.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	30	R-HSA-1482646	2-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482646.md	2-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 2-acyl LPE acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	31	R-HSA-1482691	2-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482691.md	2-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The Reactome event supports 2-acyl LPS acylation, but the seeded glycerol-3-phosphate term names the wrong substrate.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	47	R-HSA-1482533	2-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482533.md	2-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	48	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	49	R-HSA-1482547	1-acyl LPC is acylated to PC by LPCAT	yes	reactome/R-HSA-1482547.md	1-acyl LPC is acylated to PC by LPCAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	50	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	51	R-HSA-1482636	1-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482636.md	1-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	52	R-HSA-1482646	2-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482646.md	2-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	53	R-HSA-1482667	1-acyl LPE is acylated to PE by LPEAT	yes	reactome/R-HSA-1482667.md	1-acyl LPE is acylated to PE by LPEAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	54	R-HSA-1482691	2-acyl LPS is acylated to PS by LPSAT	yes	reactome/R-HSA-1482691.md	2-acyl LPS is acylated to PS by LPSAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPCAT4	genes/human/LPCAT4/LPCAT4-ai-review.yaml	LPCAT4	Q643R3	NCBITaxon:9606	Homo sapiens	55	R-HSA-75885	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	yes	reactome/R-HSA-75885.md	1-acyl LPA is acylated to PA by AGPAT (LPAAT)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated lysophospholipid acylation event.
human	LPGAT1	genes/human/LPGAT1/LPGAT1-ai-review.yaml	LPGAT1	Q92604	NCBITaxon:9606	Homo sapiens	14	R-HSA-1482925	Acyl chain remodelling of PG	yes	reactome/R-HSA-1482925.md	Acyl chain remodelling of PG	Homo sapiens	GO:0036148	phosphatidylglycerol acyl-chain remodeling	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Retain reported PG remodeling as a secondary capacity whose physiological importance differs among models.
human	LPGAT1	genes/human/LPGAT1/LPGAT1-ai-review.yaml	LPGAT1	Q92604	NCBITaxon:9606	Homo sapiens	15	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The cited remodeling event concerns lysophosphatidylglycerol or other lysophospholipid acylation, not the named lysophosphatidic-acid reaction.
human	LPGAT1	genes/human/LPGAT1/LPGAT1-ai-review.yaml	LPGAT1	Q92604	NCBITaxon:9606	Homo sapiens	16	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	enables	MF	false		MODIFY	The cited remodeling event concerns lysophosphatidylglycerol or other lysophospholipid acylation, not the named lysophosphatidic-acid reaction.
human	LPGAT1	genes/human/LPGAT1/LPGAT1-ai-review.yaml	LPGAT1	Q92604	NCBITaxon:9606	Homo sapiens	27	R-HSA-1482539	1-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482539.md	1-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated 1-acyl LPG reaction.
human	LPGAT1	genes/human/LPGAT1/LPGAT1-ai-review.yaml	LPGAT1	Q92604	NCBITaxon:9606	Homo sapiens	28	R-HSA-1482635	2-acyl LPG is acylated to PG by LPGAT	yes	reactome/R-HSA-1482635.md	2-acyl LPG is acylated to PG by LPGAT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated 2-acyl LPG reaction.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	18	R-HSA-2980766	Nuclear Envelope Breakdown	yes	reactome/R-HSA-2980766.md	Nuclear Envelope Breakdown	Homo sapiens	GO:0007077	mitotic nuclear membrane disassembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-derived pathway annotation for the nuclear-envelope context in which lipin-1/PAP is dephosphorylated (by CDK1) during mitosis. Lipin-1 PAP1 activity is indeed inhibited by mitotic phosphorylation, but a direct role in executing nuclear membrane disassembly is a pathway-level assertion, not a core lipin-1 function; keep as non-core.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	19	R-HSA-75109	Triglyceride biosynthesis	yes	reactome/R-HSA-75109.md	Triglyceride biosynthesis	Homo sapiens	GO:0019432	triglyceride biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Core biological process (Reactome ""Triglyceride biosynthesis""). Lipin-1 generates DAG, the penultimate intermediate of TAG synthesis. Consistent with the experimental IDA annotation."
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	34	R-HSA-4419948	CTDNEP1:CNEP1R1 dephosphorylates LPIN	yes	reactome/R-HSA-4419948.md	CTDNEP1:CNEP1R1 dephosphorylates LPIN	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization for the nuclear-envelope pool where lipin-1 (PAP) is dephosphorylated by the CTDNEP1:CNEP1R1 complex. Real but non-core relative to the cytosol/ER catalytic pool.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	35	R-HSA-5195402	CDK1 phosphorylates LPIN	yes	reactome/R-HSA-5195402.md	CDK1 phosphorylates LPIN	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome nuclear-envelope localization (CDK1 phosphorylates LPIN reaction context). Non-core, as above.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	36	R-HSA-5221130	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol	yes	reactome/R-HSA-5221130.md	LPIN catalyzes conversion of phosphatidic acid to diacylglycerol	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome nuclear-envelope localization tied to the PA-to-DAG conversion reaction. Non-core.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	37	R-HSA-4419948	CTDNEP1:CNEP1R1 dephosphorylates LPIN	yes	reactome/R-HSA-4419948.md	CTDNEP1:CNEP1R1 dephosphorylates LPIN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasm localization, consistent with the nuclear pool of lipin-1 (transcriptional coregulation and regulated dephosphorylation). Non-core relative to the cytosol/ER catalytic pool.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	38	R-HSA-5195402	CDK1 phosphorylates LPIN	yes	reactome/R-HSA-5195402.md	CDK1 phosphorylates LPIN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate Reactome nucleoplasm localization. Non-core, as above.
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	39	R-HSA-1483203	PA is dephosphorylated to DAG by LPIN	yes	reactome/R-HSA-1483203.md	PA is dephosphorylated to DAG by LPIN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome ER-membrane localization for the ""PA is dephosphorylated to DAG by LPIN"" reaction. Core catalytic localization; ACCEPT (consistent with experimental ER annotation)."
human	LPIN1	genes/human/LPIN1/LPIN1-ai-review.yaml	LPIN1	Q14693	NCBITaxon:9606	Homo sapiens	40	R-HSA-75899	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate	yes	reactome/R-HSA-75899.md	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome ER-membrane localization tied to the DAG-3-phosphate hydrolysis reaction. Core catalytic localization; ACCEPT.
human	LPIN2	genes/human/LPIN2/LPIN2-ai-review.yaml	LPIN2	Q92539	NCBITaxon:9606	Homo sapiens	14	R-HSA-75109	Triglyceride biosynthesis	yes	reactome/R-HSA-75109.md	Triglyceride biosynthesis	Homo sapiens	GO:0019432	triglyceride biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Accepted as the biosynthetic pathway receiving diacylglycerol from LPIN2 catalysis.
human	LPIN2	genes/human/LPIN2/LPIN2-ai-review.yaml	LPIN2	Q92539	NCBITaxon:9606	Homo sapiens	17	R-HSA-1483203	PA is dephosphorylated to DAG by LPIN	yes	reactome/R-HSA-1483203.md	PA is dephosphorylated to DAG by LPIN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated LPIN-mediated PA-to-DAG event.
human	LPIN2	genes/human/LPIN2/LPIN2-ai-review.yaml	LPIN2	Q92539	NCBITaxon:9606	Homo sapiens	18	R-HSA-75899	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate	yes	reactome/R-HSA-75899.md	1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the ER-membrane location of the curated human phosphatidate-phosphatase reaction.
human	LPIN3	genes/human/LPIN3/LPIN3-ai-review.yaml	LPIN3	Q9BQK8	NCBITaxon:9606	Homo sapiens	12	R-HSA-1483203	PA is dephosphorylated to DAG by LPIN	yes	reactome/R-HSA-1483203.md	PA is dephosphorylated to DAG by LPIN	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Accepted as the membrane context in which LPIN3 accesses phosphatidate for catalysis.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	110	R-HSA-174757	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols	yes	reactome/R-HSA-174757.md	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	111	R-HSA-2395768	LPL hydrolyses TGs from mature CMs	yes	reactome/R-HSA-2395768.md	LPL hydrolyses TGs from mature CMs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	112	R-HSA-560498	Expression of Lipoprotein lipase (LPL)	yes	reactome/R-HSA-560498.md	Expression of Lipoprotein lipase (LPL)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	113	R-HSA-6784628	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer	yes	reactome/R-HSA-6784628.md	PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	114	R-HSA-6784676	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer	yes	reactome/R-HSA-6784676.md	PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	115	R-HSA-6784861	HSPG binds LPL dimer	yes	reactome/R-HSA-6784861.md	HSPG binds LPL dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPL	genes/human/LPL/LPL-ai-review.yaml	LPL	P06858	NCBITaxon:9606	Homo sapiens	116	R-HSA-8857928	GPIHBP1 binds HSPG:LPL dimer	yes	reactome/R-HSA-8857928.md	GPIHBP1 binds HSPG:LPL dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted: LPL is secreted and functions extracellularly on circulating lipoprotein particles at the vascular surface.
human	LPO	genes/human/LPO/LPO-ai-review.yaml	LPO	P22079	NCBITaxon:9606	Homo sapiens	14	R-HSA-8855490	Lactoperoxidase (LPO) produces OSCN-	yes	reactome/R-HSA-8855490.md	Lactoperoxidase (LPO) produces OSCN-	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Accepted as core LPO biology.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	20	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation (canonical retinoid cycle in rods) to retinoid metabolic process. LRAT esterifies all-trans-retinol to retinyl esters, the entry step of the retinoid cycle, so this is a correct process. It is the broad parent of the more specific retinol metabolic process (GO:0042572); retained as non-core relative to that specific term.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	21	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS annotation (Retinoid metabolism and transport) to retinoid metabolic process. Correct broad process for LRAT's role in retinoid esterification/storage; broader parent of the specific GO:0042572. Retained as non-core.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	22	R-HSA-975608	LRAT esterifies RBP2:atROL and FACYLs to atREs	yes	reactome/R-HSA-975608.md	LRAT esterifies RBP2:atROL and FACYLs to atREs	Homo sapiens	GO:0047173	phosphatidylcholine-retinol O-acyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS annotation (reaction ""LRAT esterifies RBP2:atROL and FACYLs to atREs"") to the precise molecular function phosphatidylcholine-retinol O-acyltransferase activity. This matches the enzyme's core catalytic function and the experimental IDA. Core function."
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	23	R-HSA-2404137	LRAT esterifies RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2404137.md	LRAT esterifies RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0016416	O-palmitoyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to O-palmitoyltransferase activity. Palmitoyl is one of the acyl groups LRAT transfers (retinyl palmitate is the major product), so this is not wrong, but GO:0016416 is a less informative sibling of the precise GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity and does not capture that the acyl donor is lecithin or that the acceptor is retinol. Over-annotation relative to the specific term.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	24	R-HSA-2453855	LRAT esterifies RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2453855.md	LRAT esterifies RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0016416	O-palmitoyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to O-palmitoyltransferase activity (duplicate of the R-HSA-2404137 annotation). Palmitoyl transfer is part of the LRAT reaction but this generic term is less informative than the specific GO:0047173. Over-annotation relative to the specific term.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	25	R-HSA-2466710	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2466710.md	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0016416	O-palmitoyltransferase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS annotation to O-palmitoyltransferase activity (from the ""Defective LRAT"" reaction). Same generic palmitoyltransferase term; less informative than the specific GO:0047173. Over-annotation relative to the specific term."
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	30	R-HSA-2466710	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2466710.md	Defective LRAT does not esterify RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to endoplasmic reticulum membrane. Correct and functionally central compartment for LRAT; consistent with the UniProt subcellular location and the IEA annotation to the same term. Core localization.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	31	R-HSA-2404137	LRAT esterifies RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2404137.md	LRAT esterifies RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to endoplasmic reticulum membrane (duplicate). Correct core compartment for LRAT.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	32	R-HSA-2453855	LRAT esterifies RBP1:atROL and FACYLs to atREs	yes	reactome/R-HSA-2453855.md	LRAT esterifies RBP1:atROL and FACYLs to atREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to endoplasmic reticulum membrane (duplicate). Correct core compartment for LRAT.
human	LRAT	genes/human/LRAT/LRAT-ai-review.yaml	LRAT	O95237	NCBITaxon:9606	Homo sapiens	33	R-HSA-975608	LRAT esterifies RBP2:atROL and FACYLs to atREs	yes	reactome/R-HSA-975608.md	LRAT esterifies RBP2:atROL and FACYLs to atREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to endoplasmic reticulum membrane (duplicate). Correct core compartment for LRAT.
human	LRFN1	genes/human/LRFN1/LRFN1-ai-review.yaml	LRFN1	Q9P244	NCBITaxon:9606	Homo sapiens	8	R-HSA-8849881	SALM2 associate with AMPA and NMDA receptors	yes	reactome/R-HSA-8849881.md	SALM2 associate with AMPA and NMDA receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places human SALM2/LRFN1 with glutamate receptors at excitatory synaptic plasma membrane, supporting the broader plasma membrane annotation.
human	LRFN1	genes/human/LRFN1/LRFN1-ai-review.yaml	LRFN1	Q9P244	NCBITaxon:9606	Homo sapiens	9	R-HSA-8849891	SALMs 1-3 bind to PSD-95 family members	yes	reactome/R-HSA-8849891.md	SALMs 1-3 bind to PSD-95 family members	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event describes SALM2/LRFN1 association with postsynaptic PDZ scaffolds, consistent with residence in the synaptic plasma membrane.
human	LRFN1	genes/human/LRFN1/LRFN1-ai-review.yaml	LRFN1	Q9P244	NCBITaxon:9606	Homo sapiens	10	R-HSA-8849900	SALMs1-3 bind each other in cis interactions	yes	reactome/R-HSA-8849900.md	SALMs1-3 bind each other in cis interactions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event models cis homo- and heteromeric SALM complexes in the membrane, supporting plasma membrane localization of SALM2/LRFN1.
human	LRFN2	genes/human/LRFN2/LRFN2-ai-review.yaml	LRFN2	Q9ULH4	NCBITaxon:9606	Homo sapiens	13	R-HSA-8849882	SALMs 1-4 bind reticulon 3	yes	reactome/R-HSA-8849882.md	SALMs 1-4 bind reticulon 3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places human SALM1/LRFN2 in an RTN3-associated membrane complex in brain, while the GO annotation records the broader plasma-membrane location.
human	LRFN2	genes/human/LRFN2/LRFN2-ai-review.yaml	LRFN2	Q9ULH4	NCBITaxon:9606	Homo sapiens	14	R-HSA-8849891	SALMs 1-3 bind to PSD-95 family members	yes	reactome/R-HSA-8849891.md	SALMs 1-3 bind to PSD-95 family members	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event describes SALM1/LRFN2 binding to PSD-95-family postsynaptic scaffolds, consistent with synaptic plasma-membrane residence.
human	LRFN2	genes/human/LRFN2/LRFN2-ai-review.yaml	LRFN2	Q9ULH4	NCBITaxon:9606	Homo sapiens	15	R-HSA-8849900	SALMs1-3 bind each other in cis interactions	yes	reactome/R-HSA-8849900.md	SALMs1-3 bind each other in cis interactions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event models cis homo- and heteromeric complexes among SALM1-3 in the membrane, supporting plasma-membrane localization of SALM1/LRFN2.
human	LRFN2	genes/human/LRFN2/LRFN2-ai-review.yaml	LRFN2	Q9ULH4	NCBITaxon:9606	Homo sapiens	16	R-HSA-8849906	SALM1 binds NMDA receptor	yes	reactome/R-HSA-8849906.md	SALM1 binds NMDA receptor	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event specifically describes SALM1/LRFN2 association with NMDA receptors at early excitatory synapses, consistent with plasma- membrane residence.
human	LRFN3	genes/human/LRFN3/LRFN3-ai-review.yaml	LRFN3	Q9BTN0	NCBITaxon:9606	Homo sapiens	17	R-HSA-8849882	SALMs 1-4 bind reticulon 3	yes	reactome/R-HSA-8849882.md	SALMs 1-4 bind reticulon 3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places human SALM4 in a plasma-membrane complex with reticulon 3, consistent with LRFN3's type-I transmembrane topology.
human	LRFN3	genes/human/LRFN3/LRFN3-ai-review.yaml	LRFN3	Q9BTN0	NCBITaxon:9606	Homo sapiens	18	R-HSA-8849908	SALM4 binds flotillin-1	yes	reactome/R-HSA-8849908.md	SALM4 binds flotillin-1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places human SALM4 in a plasma-membrane interaction with the lipid-raft-associated protein flotillin-1.
human	LRFN4	genes/human/LRFN4/LRFN4-ai-review.yaml	LRFN4	Q6PJG9	NCBITaxon:9606	Homo sapiens	18	R-HSA-8849891	SALMs 1-3 bind to PSD-95 family members	yes	reactome/R-HSA-8849891.md	SALMs 1-3 bind to PSD-95 family members	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places human SALM3/LRFN4 in membrane-associated complexes with PSD-95-family scaffolds.
human	LRFN4	genes/human/LRFN4/LRFN4-ai-review.yaml	LRFN4	Q6PJG9	NCBITaxon:9606	Homo sapiens	19	R-HSA-8849900	SALMs1-3 bind each other in cis interactions	yes	reactome/R-HSA-8849900.md	SALMs1-3 bind each other in cis interactions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome models SALM3/LRFN4 in cis homo- and heteromeric complexes with SALM1 and SALM2 at the membrane.
human	LRFN4	genes/human/LRFN4/LRFN4-ai-review.yaml	LRFN4	Q6PJG9	NCBITaxon:9606	Homo sapiens	20	R-HSA-8855648	SALM3 binds LAR-RPTP	yes	reactome/R-HSA-8855648.md	SALM3 binds LAR-RPTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places SALM3/LRFN4 in a transsynaptic complex with LAR-family receptor protein tyrosine phosphatases.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	32	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places LRG1 extracellularly after exocytosis from tertiary neutrophil granules.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	33	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places LRG1 extracellularly after exocytosis from specific neutrophil granules.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	34	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome places LRG1 extracellularly after exocytosis from ficolin-1-rich neutrophil granules.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	35	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns LRG1 to the lumen of specific neutrophil granules before exocytosis.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	36	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns LRG1 to the lumen of tertiary neutrophil granules before exocytosis.
human	LRG1	genes/human/LRG1/LRG1-ai-review.yaml	LRG1	P02750	NCBITaxon:9606	Homo sapiens	37	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome assigns LRG1 to the lumen of ficolin-1-rich neutrophil granules before exocytosis.
human	LRIG1	genes/human/LRIG1/LRIG1-ai-review.yaml	LRIG1	Q96JA1	NCBITaxon:9606	Homo sapiens	12	R-HSA-8875431	LRIG1 undergoes ubiquitination	yes	reactome/R-HSA-8875431.md	LRIG1 undergoes ubiquitination	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event models ubiquitination of membrane LRIG1 after MET binding; plasma membrane is a valid starting location for this human signaling event.
human	LRIG1	genes/human/LRIG1/LRIG1-ai-review.yaml	LRIG1	Q96JA1	NCBITaxon:9606	Homo sapiens	13	R-HSA-8875443	USP8 deubiquitinates LRIG1	yes	reactome/R-HSA-8875443.md	USP8 deubiquitinates LRIG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome event places membrane LRIG1 in the USP8-regulated MET-downregulation pathway; plasma membrane is consistent with its receptor-associated state.
human	LRIG1	genes/human/LRIG1/LRIG1-ai-review.yaml	LRIG1	Q96JA1	NCBITaxon:9606	Homo sapiens	14	R-HSA-8875374	MET binds LRIG1	yes	reactome/R-HSA-8875374.md	MET binds LRIG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Human LRIG1 binds cell-surface MET before their lysosomal trafficking; the Reactome statement therefore supports plasma membrane for the receptor-associated LRIG1 state.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	37	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	retinoid metabolic process is retained as a non-core biological-process annotation for LRP1; it records a supported context, interaction, localization, or pathway branch that is secondary to LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	51	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005041	low-density lipoprotein particle receptor activity	TAS	enables	MF	false		ACCEPT	low-density lipoprotein particle receptor activity is retained as a core molecular-function annotation for LRP1; it captures activity or binding specificity within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	104	R-HSA-2168897	LRP1 (CD91) binds Hemopexin:heme	yes	reactome/R-HSA-2168897.md	LRP1 (CD91) binds Hemopexin:heme	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	105	R-HSA-2230983	LRP1:Hemopexin:heme is endocytosed	yes	reactome/R-HSA-2230983.md	LRP1:Hemopexin:heme is endocytosed	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	106	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP1	genes/human/LRP1/LRP1-ai-review.yaml	LRP1	Q07954	NCBITaxon:9606	Homo sapiens	107	R-HSA-2230983	LRP1:Hemopexin:heme is endocytosed	yes	reactome/R-HSA-2230983.md	LRP1:Hemopexin:heme is endocytosed	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	endocytic vesicle membrane is retained as a core cellular-component/localization annotation for LRP1; it captures site of action or component context within the synthesized core biology: LRP1 cell-surface/coated-pit/endosomal receptor biology, ligand and calcium binding, apolipoprotein/lipoprotein and alpha-2-macroglobulin cargo recognition, receptor-mediated endocytosis, transcytosis, phagocytic/lysosomal clearance, and Alzheimer-relevant amyloid-beta/tau handling.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	49	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome:R-HSA-975634 provides statement-level support for the LRP2 annotation to retinoid metabolic process.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	50	R-HSA-9758890	Transport of RCbl within the body	yes	reactome/R-HSA-9758890.md	Transport of RCbl within the body	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome:R-HSA-9758890 provides statement-level support for the LRP2 annotation to cobalamin transport.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	51	R-HSA-196791	Vitamin D (calciferol) metabolism	yes	reactome/R-HSA-196791.md	Vitamin D (calciferol) metabolism	Homo sapiens	GO:0042359	vitamin D metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome:R-HSA-196791 provides statement-level support for the LRP2 annotation to vitamin D metabolic process.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	56	R-HSA-350168	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	yes	reactome/R-HSA-350168.md	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	Homo sapiens	GO:0038024	cargo receptor activity	TAS	enables	MF	false		ACCEPT	Reactome:R-HSA-350168 provides statement-level support for the LRP2 annotation to cargo receptor activity.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	59	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005041	low-density lipoprotein particle receptor activity	TAS	enables	MF	false		MODIFY	Reactome:R-HSA-2404131 provides statement-level support for the LRP2 annotation to low-density lipoprotein particle receptor activity.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	69	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8868658 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	70	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8868659 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	71	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8868660 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	72	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8868661 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	73	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8869438 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	74	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8871193 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	75	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome:R-HSA-8871194 provides statement-level support for the LRP2 annotation to clathrin-coated endocytic vesicle membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	109	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-2404131 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	110	R-HSA-350168	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	yes	reactome/R-HSA-350168.md	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-350168 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	111	R-HSA-8863472	DAB2 binds LRP2	yes	reactome/R-HSA-8863472.md	DAB2 binds LRP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8863472 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	112	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8867754 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	113	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8867756 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	114	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868071 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	115	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868072 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	116	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868230 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	117	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868236 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	118	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868648 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	119	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868651 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	120	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-8868661 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	121	R-HSA-9759202	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-9759202.md	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-9759202 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP2	genes/human/LRP2/LRP2-ai-review.yaml	LRP2	P98164	NCBITaxon:9606	Homo sapiens	122	R-HSA-9759209	LRP2 binds extracellular TCN2:RCbl	yes	reactome/R-HSA-9759209.md	LRP2 binds extracellular TCN2:RCbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome:R-HSA-9759209 provides statement-level support for the LRP2 annotation to plasma membrane.
human	LRP5	genes/human/LRP5/LRP5-ai-review.yaml	LRP5	O75197	NCBITaxon:9606	Homo sapiens	35	R-HSA-5339711	misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling	yes	reactome/R-HSA-5339711.md	misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-5339711 associates LRP5 with plasma membrane; evidence specificity and core relevance were reviewed.
human	LRP5	genes/human/LRP5/LRP5-ai-review.yaml	LRP5	O75197	NCBITaxon:9606	Homo sapiens	56	R-HSA-201677	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	yes	reactome/R-HSA-201677.md	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-201677 associates LRP5 with plasma membrane; evidence specificity and core relevance were reviewed.
human	LRP5	genes/human/LRP5/LRP5-ai-review.yaml	LRP5	O75197	NCBITaxon:9606	Homo sapiens	57	R-NUL-1458902	frog CK1gamma phosphorylates LRP5/6	yes	reactome/R-NUL-1458902.md	frog CK1gamma phosphorylates LRP5/6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	TAS annotation from Reactome:R-NUL-1458902 associates LRP5 with plasma membrane; evidence specificity and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	84	R-NUL-209104	Frog CKIgamma further phosphorylates Human LRP6 in the receptor complex	yes	reactome/R-NUL-209104.md	Frog CKIgamma further phosphorylates Human LRP6 in the receptor complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	TAS annotation from Reactome:R-NUL-209104 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	104	R-HSA-5368596	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	yes	reactome/R-HSA-5368596.md	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-5368596 associates LRP6 with early endosome membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	105	R-NUL-1458871	mFz8CRD binds LRP6N in vitro	yes	reactome/R-NUL-1458871.md	mFz8CRD binds LRP6N in vitro	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	TAS annotation from Reactome:R-NUL-1458871 associates LRP6 with extracellular region; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	108	R-HSA-201677	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	yes	reactome/R-HSA-201677.md	Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-201677 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	109	R-NUL-1458902	frog CK1gamma phosphorylates LRP5/6	yes	reactome/R-NUL-1458902.md	frog CK1gamma phosphorylates LRP5/6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	TAS annotation from Reactome:R-NUL-1458902 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	110	R-HSA-5368596	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	yes	reactome/R-HSA-5368596.md	WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-5368596 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	143	R-HSA-1504186	DVL recruits GSK3beta:AXIN1 to the receptor complex	yes	reactome/R-HSA-1504186.md	DVL recruits GSK3beta:AXIN1 to the receptor complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-1504186 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	144	R-HSA-3769397	SOST binds LRP5/6	yes	reactome/R-HSA-3769397.md	SOST binds LRP5/6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-3769397 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	145	R-HSA-3769401	DKK and KRM bind LRP5/6	yes	reactome/R-HSA-3769401.md	DKK and KRM bind LRP5/6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-3769401 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	146	R-HSA-4641236	USP8 deubiquitinates FZD to potentiate WNT signaling	yes	reactome/R-HSA-4641236.md	USP8 deubiquitinates FZD to potentiate WNT signaling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	TAS annotation from Reactome:R-HSA-4641236 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	147	R-HSA-4641249	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex	yes	reactome/R-HSA-4641249.md	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-4641249 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	148	R-HSA-4641253	ZNRF3 ubiquitinates FZD to promote its downregulation	yes	reactome/R-HSA-4641253.md	ZNRF3 ubiquitinates FZD to promote its downregulation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-4641253 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	149	R-HSA-5340587	RNF43 frameshift mutants show enhanced WNT siganling	yes	reactome/R-HSA-5340587.md	RNF43 frameshift mutants show enhanced WNT siganling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		UNDECIDED	TAS annotation from Reactome:R-HSA-5340587 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	150	R-HSA-5368586	DKK promotes clathrin-dependent internalization of LRP6	yes	reactome/R-HSA-5368586.md	DKK promotes clathrin-dependent internalization of LRP6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-5368586 associates LRP6 with plasma membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP6	genes/human/LRP6/LRP6-ai-review.yaml	LRP6	O75581	NCBITaxon:9606	Homo sapiens	151	R-HSA-5368586	DKK promotes clathrin-dependent internalization of LRP6	yes	reactome/R-HSA-5368586.md	DKK promotes clathrin-dependent internalization of LRP6	Homo sapiens	GO:0031901	early endosome membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome:R-HSA-5368586 associates LRP6 with early endosome membrane; evidence specificity, source support, and core relevance were reviewed.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	29	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	TAS annotation of retinoid metabolic process reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	38	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005041	low-density lipoprotein particle receptor activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	TAS annotation of low-density lipoprotein particle receptor activity reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	45	R-HSA-432129	FGR binds and phosphorylates LRP8	yes	reactome/R-HSA-432129.md	FGR binds and phosphorylates LRP8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation of plasma membrane reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	46	R-HSA-2404131	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	yes	reactome/R-HSA-2404131.md	LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation of plasma membrane reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	47	R-HSA-432121	LDL binds to LRP8	yes	reactome/R-HSA-432121.md	LDL binds to LRP8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation of plasma membrane reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRP8	genes/human/LRP8/LRP8-ai-review.yaml	LRP8	Q14114	NCBITaxon:9606	Homo sapiens	48	R-HSA-8948034	FGR binds LDL:LRP8	yes	reactome/R-HSA-8948034.md	FGR binds LDL:LRP8	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation of plasma membrane reviewed against the cached source, UniProt record, and LRP8-specific biology.
human	LRPPRC	genes/human/LRPPRC/LRPPRC-ai-review.yaml	LRPPRC	P42704	NCBITaxon:9606	Homo sapiens	36	R-HSA-9837034	SLIRP:LRPPRC binds mitochondrial RNAs	yes	reactome/R-HSA-9837034.md	SLIRP:LRPPRC binds mitochondrial RNAs	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome pathway ""SLIRP:LRPPRC binds mitochondrial RNAs"" places the complex in the mitochondrial matrix."
human	LRRC8A	genes/human/LRRC8A/LRRC8A-ai-review.yaml	LRRC8A	Q8IWT6	NCBITaxon:9606	Homo sapiens	55	R-HSA-8941543	VRAC heteromer transports I-, Cl- from cytosol to extracellular region	yes	reactome/R-HSA-8941543.md	VRAC heteromer transports I-, Cl- from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	LRRC8A is a polytopic plasma-membrane protein; this is where the swelling-activated channel operates.
human	LRRK2	genes/human/LRRK2/LRRK2-ai-review.yaml	LRRK2	Q5S007	NCBITaxon:9606	Homo sapiens	269	R-HSA-8857565	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139	yes	reactome/R-HSA-8857565.md	Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the predominant localization of LRRK2, from which it is recruited to membranes.
human	LRRK2	genes/human/LRRK2/LRRK2-ai-review.yaml	LRRK2	Q5S007	NCBITaxon:9606	Homo sapiens	270	R-HSA-8857577	LINC01139 facilitates PTK6 autophosphorylation	yes	reactome/R-HSA-8857577.md	LINC01139 facilitates PTK6 autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the predominant localization of LRRK2, from which it is recruited to membranes.
human	LRRK2	genes/human/LRRK2/LRRK2-ai-review.yaml	LRRK2	Q5S007	NCBITaxon:9606	Homo sapiens	271	R-HSA-8857583	LINC01139 promotes phosphorylation of HIF1A by PTK6	yes	reactome/R-HSA-8857583.md	LINC01139 promotes phosphorylation of HIF1A by PTK6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the predominant localization of LRRK2, from which it is recruited to membranes.
human	LRRK2	genes/human/LRRK2/LRRK2-ai-review.yaml	LRRK2	Q5S007	NCBITaxon:9606	Homo sapiens	272	R-HSA-9634702	LINC01139 promotes phosphorylation of HIF1A by LRRK2	yes	reactome/R-HSA-9634702.md	LINC01139 promotes phosphorylation of HIF1A by LRRK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the predominant localization of LRRK2, from which it is recruited to membranes.
human	LSS	genes/human/LSS/LSS-ai-review.yaml	LSS	P48449	NCBITaxon:9606	Homo sapiens	11	R-HSA-9969896	Lanosterol biosynthesis	yes	reactome/R-HSA-9969896.md	Lanosterol biosynthesis	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing LSS in cholesterol biosynthesis (the lanosterol biosynthesis module of the cholesterol pathway).
human	LSS	genes/human/LSS/LSS-ai-review.yaml	LSS	P48449	NCBITaxon:9606	Homo sapiens	12	R-HSA-191366	Squalene 2,3-epoxide cyclizes, forming lanosterol	yes	reactome/R-HSA-191366.md	Squalene 2,3-epoxide cyclizes, forming lanosterol	Homo sapiens	GO:0000250	lanosterol synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of the core catalytic function: LSS cyclizes squalene 2,3-epoxide to lanosterol.
human	LSS	genes/human/LSS/LSS-ai-review.yaml	LSS	P48449	NCBITaxon:9606	Homo sapiens	23	R-HSA-1655828	Expression of Lanosterol Synthase (LSS)	yes	reactome/R-HSA-1655828.md	Expression of Lanosterol Synthase (LSS)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of ER-membrane localization (from the LSS expression event).
human	LSS	genes/human/LSS/LSS-ai-review.yaml	LSS	P48449	NCBITaxon:9606	Homo sapiens	24	R-HSA-191366	Squalene 2,3-epoxide cyclizes, forming lanosterol	yes	reactome/R-HSA-191366.md	Squalene 2,3-epoxide cyclizes, forming lanosterol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that LSS is located on the ER membrane and active as a monomer, in the lanosterol-forming cyclization reaction.
human	LTN1	genes/human/LTN1/LTN1-ai-review.yaml	LTN1	O94822	NCBITaxon:9606	Homo sapiens	15	R-HSA-9948299	Reactome: rescue of stalled ribosome (LTN1)	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Reactome curation of LTN1 in stalled-ribosome rescue, consistent with experimental evidence and the IBA/IDA annotations.
human	LTN1	genes/human/LTN1/LTN1-ai-review.yaml	LTN1	O94822	NCBITaxon:9606	Homo sapiens	17	R-HSA-9948362	Reactome: LTN1 ubiquitin ligase activity	yes	reactome/R-HSA-9948362.md	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the core RING E3 ligase activity of LTN1, consistent with experimental evidence.
human	LTN1	genes/human/LTN1/LTN1-ai-review.yaml	LTN1	O94822	NCBITaxon:9606	Homo sapiens	29	R-HSA-9948318	Reactome: LTN1 cytosol localization	yes	reactome/R-HSA-9948318.md	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of LTN1 cytosolic localization.
human	LTN1	genes/human/LTN1/LTN1-ai-review.yaml	LTN1	O94822	NCBITaxon:9606	Homo sapiens	30	R-HSA-9948362	Reactome: LTN1 ubiquitin ligase activity	yes	reactome/R-HSA-9948362.md	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of LTN1 cytosolic localization.
human	LTN1	genes/human/LTN1/LTN1-ai-review.yaml	LTN1	O94822	NCBITaxon:9606	Homo sapiens	31	R-HSA-9948427	Reactome: LTN1 cytosol localization	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of LTN1 cytosolic localization.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	6	R-HSA-5621481	C-type lectin receptors (CLRs)	yes	reactome/R-HSA-5621481.md	C-type lectin receptors (CLRs)	Homo sapiens	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Stimulatory C-type lectin receptor signaling pathway.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	20	R-HSA-9664323	FCGR3A-mediated IL10 synthesis	yes	reactome/R-HSA-9664323.md	FCGR3A-mediated IL10 synthesis	Homo sapiens	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Negative regulation of inflammatory response to antigenic stimulus.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	42	R-HSA-1433506	Phosphorylation of APS	yes	reactome/R-HSA-1433506.md	Phosphorylation of APS	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	43	R-HSA-1472121	Phosphorylation of p-KIT on Y900 by Src kinases	yes	reactome/R-HSA-1472121.md	Phosphorylation of p-KIT on Y900 by Src kinases	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	44	R-HSA-210291	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src	yes	reactome/R-HSA-210291.md	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	45	R-HSA-2730862	Autophosphorylation of LYN kinase	yes	reactome/R-HSA-2730862.md	Autophosphorylation of LYN kinase	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	46	R-HSA-388831	Phosphorylation of CD28	yes	reactome/R-HSA-388831.md	Phosphorylation of CD28	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	47	R-HSA-388833	Phosphorylation of CTLA-4	yes	reactome/R-HSA-388833.md	Phosphorylation of CTLA-4	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	48	R-HSA-5624486	SFKs phosphorylates RAF1 on Y340,Y341	yes	reactome/R-HSA-5624486.md	SFKs phosphorylates RAF1 on Y340,Y341	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	49	R-HSA-5690702	LYN phosphorylates CD22	yes	reactome/R-HSA-5690702.md	LYN phosphorylates CD22	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	50	R-HSA-9664261	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK	yes	reactome/R-HSA-9664261.md	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine kinase activity - a core, experimentally established molecular function of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	54	R-HSA-1168459	Lyn activates ERK	yes	reactome/R-HSA-1168459.md	Lyn activates ERK	Homo sapiens	GO:0004715	non-membrane spanning protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Non-membrane spanning protein tyrosine kinase activity - the single most precise molecular-function term for LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	125	R-HSA-9707977	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	yes	reactome/R-HSA-9707977.md	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Lysosomal membrane (Reactome TAS; CSF3R degradation reaction compartment).
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	132	R-HSA-114577	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen	yes	reactome/R-HSA-114577.md	Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	133	R-HSA-114600	Fyn/Lyn-mediated phosphorylation of FcR1 gamma	yes	reactome/R-HSA-114600.md	Fyn/Lyn-mediated phosphorylation of FcR1 gamma	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	134	R-HSA-1168459	Lyn activates ERK	yes	reactome/R-HSA-1168459.md	Lyn activates ERK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	135	R-HSA-139842	Binding of Syk tyrosine kinase	yes	reactome/R-HSA-139842.md	Binding of Syk tyrosine kinase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	136	R-HSA-1433418	Phosphorylation of JAK2	yes	reactome/R-HSA-1433418.md	Phosphorylation of JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	137	R-HSA-1433428	GRB2 is indirectly recruited to p-KIT through SHP2	yes	reactome/R-HSA-1433428.md	GRB2 is indirectly recruited to p-KIT through SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	138	R-HSA-1433451	JAK2 binds to p-KIT	yes	reactome/R-HSA-1433451.md	JAK2 binds to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	139	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	yes	reactome/R-HSA-1433454.md	Phosphorylation of GAB2 by SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	140	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	141	R-HSA-1433488	Phosphorylation of SHP2 by SFKs	yes	reactome/R-HSA-1433488.md	Phosphorylation of SHP2 by SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	142	R-HSA-1433506	Phosphorylation of APS	yes	reactome/R-HSA-1433506.md	Phosphorylation of APS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	143	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	144	R-HSA-1433542	Phosphorylation and activation of VAV1	yes	reactome/R-HSA-1433542.md	Phosphorylation and activation of VAV1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	145	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	146	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	147	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	148	R-HSA-1472121	Phosphorylation of p-KIT on Y900 by Src kinases	yes	reactome/R-HSA-1472121.md	Phosphorylation of p-KIT on Y900 by Src kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	149	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	150	R-HSA-2029459	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	yes	reactome/R-HSA-2029459.md	Sequestering and phosphorylation Fc gamma receptors in the lipid rafts	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	151	R-HSA-205234	Indirect recruitment of GAB2 to p-KIT	yes	reactome/R-HSA-205234.md	Indirect recruitment of GAB2 to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	152	R-HSA-205238	SHP2 interacts with p-KIT	yes	reactome/R-HSA-205238.md	SHP2 interacts with p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	153	R-HSA-205244	Recruitment of CBL to KIT	yes	reactome/R-HSA-205244.md	Recruitment of CBL to KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	154	R-HSA-205319	Interaction of APS and p-KIT	yes	reactome/R-HSA-205319.md	Interaction of APS and p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	155	R-HSA-210291	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src	yes	reactome/R-HSA-210291.md	Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	156	R-HSA-388829	SHP2 phosphatase binds CTLA-4	yes	reactome/R-HSA-388829.md	SHP2 phosphatase binds CTLA-4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	157	R-HSA-388831	Phosphorylation of CD28	yes	reactome/R-HSA-388831.md	Phosphorylation of CD28	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	158	R-HSA-388833	Phosphorylation of CTLA-4	yes	reactome/R-HSA-388833.md	Phosphorylation of CTLA-4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	159	R-HSA-3928604	SFKs phosphorylate VAV2,3	yes	reactome/R-HSA-3928604.md	SFKs phosphorylate VAV2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	160	R-HSA-3928607	p-EPHs bind VAV2,3	yes	reactome/R-HSA-3928607.md	p-EPHs bind VAV2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	161	R-HSA-3928627	EPHB phosphorylates TIAM1	yes	reactome/R-HSA-3928627.md	EPHB phosphorylates TIAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	162	R-HSA-3928628	VAV exchanges GTP for GDP on RAC1, activating it	yes	reactome/R-HSA-3928628.md	VAV exchanges GTP for GDP on RAC1, activating it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	163	R-HSA-3928642	TIAM1 exchanges GTP for GDP on RAC1, activating it	yes	reactome/R-HSA-3928642.md	TIAM1 exchanges GTP for GDP on RAC1, activating it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	164	R-HSA-3928645	EPHB:NMDAR binds TIAM1	yes	reactome/R-HSA-3928645.md	EPHB:NMDAR binds TIAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	165	R-HSA-3928651	NGEF exchanges GTP for GDP on RHOA	yes	reactome/R-HSA-3928651.md	NGEF exchanges GTP for GDP on RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	166	R-HSA-4093327	EPHA binds TIAM1	yes	reactome/R-HSA-4093327.md	EPHA binds TIAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	167	R-HSA-4093336	p-TIAM1 exchanges GTP for GDP on RAC1, activating it	yes	reactome/R-HSA-4093336.md	p-TIAM1 exchanges GTP for GDP on RAC1, activating it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	168	R-HSA-432295	GPVI binds Fyn and Lyn	yes	reactome/R-HSA-432295.md	GPVI binds Fyn and Lyn	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	169	R-HSA-437118	GPVI stimulates PI3K beta, gamma	yes	reactome/R-HSA-437118.md	GPVI stimulates PI3K beta, gamma	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	170	R-HSA-453183	p-Y348-SYK dissociates	yes	reactome/R-HSA-453183.md	p-Y348-SYK dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	171	R-HSA-453200	SYK autophosphorylates	yes	reactome/R-HSA-453200.md	SYK autophosphorylates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	172	R-HSA-5621355	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG	yes	reactome/R-HSA-5621355.md	LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	173	R-HSA-5624486	SFKs phosphorylates RAF1 on Y340,Y341	yes	reactome/R-HSA-5624486.md	SFKs phosphorylates RAF1 on Y340,Y341	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	174	R-HSA-9012657	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	yes	reactome/R-HSA-9012657.md	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	175	R-HSA-9021627	EPOR-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-9021627.md	EPOR-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	176	R-HSA-9027272	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2	yes	reactome/R-HSA-9027272.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	177	R-HSA-9027273	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1	yes	reactome/R-HSA-9027273.md	JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	178	R-HSA-9027275	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	yes	reactome/R-HSA-9027275.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	179	R-HSA-9027281	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1	yes	reactome/R-HSA-9027281.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	180	R-HSA-9029150	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1	yes	reactome/R-HSA-9029150.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	181	R-HSA-9664261	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK	yes	reactome/R-HSA-9664261.md	Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	182	R-HSA-9664275	Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers	yes	reactome/R-HSA-9664275.md	Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	183	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	184	R-HSA-9670413	JAK2 binds to p-KIT mutants	yes	reactome/R-HSA-9670413.md	JAK2 binds to p-KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	185	R-HSA-9670414	KIT mutants bind SFKs	yes	reactome/R-HSA-9670414.md	KIT mutants bind SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	186	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	187	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	188	R-HSA-9670418	Phosphorylation of JAK2 downstream of KIT mutants	yes	reactome/R-HSA-9670418.md	Phosphorylation of JAK2 downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	189	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	190	R-HSA-9709454	EPOR binds EPOR agonists	yes	reactome/R-HSA-9709454.md	EPOR binds EPOR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	197	R-HSA-2454208	Phosphorylation of beta and gamma subunits by LYN	yes	reactome/R-HSA-2454208.md	Phosphorylation of beta and gamma subunits by LYN	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	198	R-HSA-2454240	Recruitment of SYK to p-FCERI gamma subunit	yes	reactome/R-HSA-2454240.md	Recruitment of SYK to p-FCERI gamma subunit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	199	R-HSA-2730833	Phosphorylation of TEC kinases by p-SYK	yes	reactome/R-HSA-2730833.md	Phosphorylation of TEC kinases by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	200	R-HSA-2730843	Phosphorylation of LAT by p-SYK	yes	reactome/R-HSA-2730843.md	Phosphorylation of LAT by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	201	R-HSA-2730851	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2730851.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	202	R-HSA-2730862	Autophosphorylation of LYN kinase	yes	reactome/R-HSA-2730862.md	Autophosphorylation of LYN kinase	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	203	R-HSA-2730882	Phosphorylation of PKC-theta	yes	reactome/R-HSA-2730882.md	Phosphorylation of PKC-theta	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	204	R-HSA-2730884	Phosphorylation of NTAL by p-SYK/Lyn	yes	reactome/R-HSA-2730884.md	Phosphorylation of NTAL by p-SYK/Lyn	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	205	R-HSA-2730886	Phosphorylation of SHC by SYK kinase	yes	reactome/R-HSA-2730886.md	Phosphorylation of SHC by SYK kinase	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	206	R-HSA-5690702	LYN phosphorylates CD22	yes	reactome/R-HSA-5690702.md	LYN phosphorylates CD22	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	207	R-HSA-9674816	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	yes	reactome/R-HSA-9674816.md	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	208	R-HSA-9677579	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN	yes	reactome/R-HSA-9677579.md	CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	209	R-HSA-9677585	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1	yes	reactome/R-HSA-9677585.md	CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane (cytoplasmic face) - the principal functional location of LYN.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	241	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions).
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	242	R-HSA-9707977	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	yes	reactome/R-HSA-9707977.md	CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Endocytic vesicle membrane (Reactome TAS; receptor internalization reactions).
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	244	R-HSA-388841	Regulation of T cell activation by CD28 family	yes	reactome/R-HSA-388841.md	Regulation of T cell activation by CD28 family	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	T cell costimulation.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	245	R-HSA-389356	Co-stimulation by CD28	yes	reactome/R-HSA-389356.md	Co-stimulation by CD28	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	T cell costimulation.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	261	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	yes	reactome/R-HSA-2454202.md	Fc epsilon receptor (FCERI) signaling	Homo sapiens	GO:0038095	Fc-epsilon receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	Fc-epsilon receptor signaling pathway - a receptor-proximal process LYN directly executes.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	263	R-HSA-2029480	Fcgamma receptor (FCGR) dependent phagocytosis	yes	reactome/R-HSA-2029480.md	Fcgamma receptor (FCGR) dependent phagocytosis	Homo sapiens	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Fc-gamma receptor signaling pathway involved in phagocytosis.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	264	R-HSA-9664422	FCGR3A-mediated phagocytosis	yes	reactome/R-HSA-9664422.md	FCGR3A-mediated phagocytosis	Homo sapiens	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Fc-gamma receptor signaling pathway involved in phagocytosis.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	285	R-HSA-2682334	EPH-Ephrin signaling	yes	reactome/R-HSA-2682334.md	EPH-Ephrin signaling	Homo sapiens	GO:0048013	ephrin receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Ephrin receptor signaling pathway.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	294	R-HSA-202733	Cell surface interactions at the vascular wall	yes	reactome/R-HSA-202733.md	Cell surface interactions at the vascular wall	Homo sapiens	GO:0050900	leukocyte migration	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Leukocyte migration.
human	LYN	genes/human/LYN/LYN-ai-review.yaml	LYN	P07948	NCBITaxon:9606	Homo sapiens	299	R-HSA-982772	Growth hormone receptor signaling	yes	reactome/R-HSA-982772.md	Growth hormone receptor signaling	Homo sapiens	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Growth hormone receptor signaling pathway via JAK-STAT.
human	LYPD2	genes/human/LYPD2/LYPD2-ai-review.yaml	LYPD2	Q6UXB3	NCBITaxon:9606	Homo sapiens	4	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region - GPI-anchored extracellular protein, consistent with Ly6/uPAR family localization.
human	LYPD2	genes/human/LYPD2/LYPD2-ai-review.yaml	LYPD2	Q6UXB3	NCBITaxon:9606	Homo sapiens	5	R-HSA-8940388	GPLD1 hydrolyses GPI-anchors from proteins	yes	reactome/R-HSA-8940388.md	GPLD1 hydrolyses GPI-anchors from proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane - GPI-anchored to membrane.
human	LYRM4	genes/human/LYRM4/LYRM4-ai-review.yaml	LYRM4	Q9HD34	NCBITaxon:9606	Homo sapiens	31	R-HSA-1362408	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	yes	reactome/R-HSA-1362408.md	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for [2Fe-2S] cluster assembly. The ISC machinery operates in the mitochondrial matrix.
human	LYRM4	genes/human/LYRM4/LYRM4-ai-review.yaml	LYRM4	Q9HD34	NCBITaxon:9606	Homo sapiens	32	R-HSA-1362416	Frataxin binds iron	yes	reactome/R-HSA-1362416.md	Frataxin binds iron	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for frataxin binding iron. Consistent with mitochondrial matrix localization of the ISC complex.
human	LYRM4	genes/human/LYRM4/LYRM4-ai-review.yaml	LYRM4	Q9HD34	NCBITaxon:9606	Homo sapiens	33	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for Fe-S cluster transfer to SDHB.
human	LYRM4	genes/human/LYRM4/LYRM4-ai-review.yaml	LYRM4	Q9HD34	NCBITaxon:9606	Homo sapiens	34	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for [2Fe-2S] insertion into UQCRFS1.
human	LYRM7	genes/human/LYRM7/LYRM7-ai-review.yaml	LYRM7	Q5U5X0	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865881	Complex III assembly	yes	reactome/R-HSA-9865881.md	Complex III assembly	Homo sapiens	GO:0034551	mitochondrial respiratory chain complex III assembly	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation placing LYRM7 in the Complex III assembly pathway. Matches the core, experimentally supported BP.
human	LYRM7	genes/human/LYRM7/LYRM7-ai-review.yaml	LYRM7	Q5U5X0	NCBITaxon:9606	Homo sapiens	16	R-HSA-9866253	apo-UQCRFS1 binds LYRM7	yes	reactome/R-HSA-9866253.md	apo-UQCRFS1 binds LYRM7	Homo sapiens	GO:0044183	protein folding chaperone	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of the protein folding chaperone MF, corresponding to the reaction in which apo-UQCRFS1 binds and is stabilised by LYRM7. Matches the core chaperone function.
human	LYRM7	genes/human/LYRM7/LYRM7-ai-review.yaml	LYRM7	Q5U5X0	NCBITaxon:9606	Homo sapiens	17	R-HSA-9866253	apo-UQCRFS1 binds LYRM7	yes	reactome/R-HSA-9866253.md	apo-UQCRFS1 binds LYRM7	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation of LYRM7 to the mitochondrial matrix, the compartment where apo-UQCRFS1 binds LYRM7. Matches experimental and curated localisation.
human	LYRM7	genes/human/LYRM7/LYRM7-ai-review.yaml	LYRM7	Q5U5X0	NCBITaxon:9606	Homo sapiens	18	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localisation of LYRM7 to the mitochondrial matrix, associated with the reaction inserting the [2Fe-2S] cluster into UQCRFS1 as part of the UQCRFS1:LYRM7 complex.
human	LZTFL1	genes/human/LZTFL1/LZTFL1-ai-review.yaml	LZTFL1	Q9NQ48	NCBITaxon:9606	Homo sapiens	24	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) cytosol localization, consistent with the experimentally established cytoplasmic/cytosolic distribution of LZTFL1.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	73	R-HSA-141409	MAD1 binding to kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MAD1 binding to kinetochore. MAD2 is present in cytosol before activation.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	74	R-HSA-141422	MAD2 conversion to inhibitory state	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MAD2 conversion to inhibitory state via MAD1 interaction.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	75	R-HSA-141431	MAD2 association with MAD1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MAD2 association with MAD1 kinetochore complex.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	76	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for release of activated MAD2 from kinetochores.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	77	R-HSA-1638803	PLK1 phosphorylation of cohesin at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PLK1 phosphorylation of cohesin at centromeres.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	78	R-HSA-1638821	PP2A-B56 dephosphorylation of centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PP2A-B56 dephosphorylation of centromeric cohesin.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	79	R-HSA-2467809	ESPL1 (Separase) cleavage of centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ESPL1 (Separase) cleavage of centromeric cohesin.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	80	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for separation of sister chromatids.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	81	R-HSA-2468287	CDK1 phosphorylation of CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CDK1 phosphorylation of CDCA5 (Sororin) at centromeres.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	82	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kinetochore assembly.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	83	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for kinetochore capture of astral microtubules.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	84	R-HSA-5666129	CDC42:GTP recruiting DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for CDC42:GTP recruiting DIAPH2-2 to kinetochores.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	85	R-HSA-5666160	AURKB phosphorylation of DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for AURKB phosphorylation of DIAPH2-2 at kinetochores.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	86	R-HSA-5666169	Kinetochore capture regulation by CDC42:GTP:p-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for kinetochore capture regulation by CDC42:GTP:p-DIAPH2-2.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	87	R-HSA-9648114	EML4 recruiting NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for EML4 recruiting NUDC to mitotic spindle.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	92	R-HSA-141423	MCC complex binding to APC/C complex	yes	reactome/R-HSA-141423.md	Binding of the MCC complex to the APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MCC complex binding to APC/C complex.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	93	R-HSA-141429	APC/C inactivation via CDC20 sequestration	yes	reactome/R-HSA-141429.md	Inactivation of APC/C via CDC20 sequestration	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for APC/C inactivation via CDC20 sequestration.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	94	R-HSA-141437	MCC complex formation	yes	reactome/R-HSA-141437.md	Formation of the MCC complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MCC complex formation.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	95	R-HSA-174104	Ubiquitination of Cyclin A by APC/C:Cdc20	yes	reactome/R-HSA-174104.md	Ubiquitination of Cyclin A by APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for ubiquitination of Cyclin A by APC/C:Cdc20.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	96	R-HSA-174171	Cyclin A association with APC/C	yes	reactome/R-HSA-174171.md	Association of Cyclin A with the APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for Cyclin A association with APC/C.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	97	R-HSA-174238	APC/C:Cdc20 activation by MCC dissociation	yes	reactome/R-HSA-174238.md	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for APC/C:Cdc20 activation by MCC dissociation.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	98	R-HSA-174255	Multiubiquitinated Cyclin A degradation	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for multiubiquitinated Cyclin A degradation.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	99	R-HSA-179410	Nek2A association with MCC:APC/C	yes	reactome/R-HSA-179410.md	Association of Nek2A with MCC:APC/C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for Nek2A association with MCC:APC/C.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	100	R-HSA-179417	Nek2A multiubiquitination	yes	reactome/R-HSA-179417.md	Multiubiquitination of Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for Nek2A multiubiquitination.
human	MAD2L1	genes/human/MAD2L1/MAD2L1-ai-review.yaml	MAD2L1	Q13257	NCBITaxon:9606	Homo sapiens	101	R-HSA-179421	Nek2A degradation	yes	reactome/R-HSA-179421.md	Degradation of multiubiquitinated Nek2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for Nek2A degradation.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	45	R-HSA-110311	Translesion synthesis	yes	reactome/R-HSA-110311.md	POLZ extends translesion synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for Pol zeta function in nucleoplasm.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	46	R-HSA-110322	Formation of Pol zeta complex	yes	reactome/R-HSA-110322.md	Formation of Pol zeta complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for Pol zeta complex formation.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	47	R-HSA-5652151	REV1 recruits POLZ to damaged DNA	yes	reactome/R-HSA-5652151.md	REV1 recruits POLZ to (AP:Cyt)-DNA Template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for REV1 recruiting Pol zeta.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	48	R-HSA-5655835	POLK forms quaternary complex with REV1 and POLZ	yes	reactome/R-HSA-5655835.md	POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLK-REV1-POLZ complex.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	49	R-HSA-5655892	POLK incorporates dNMP opposite damaged DNA	yes	reactome/R-HSA-5655892.md	POLK incorporates dNMP opposite to damaged DNA base	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLK nucleotide incorporation.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	50	R-HSA-5655965	POLK and POLZ cooperate in elongation	yes	reactome/R-HSA-5655965.md	POLK and POLZ cooperate in elongation of mispaired primer termini	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLK-POLZ cooperation.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	51	R-HSA-5656105	POLI binds REV1 and monoUb-PCNA	yes	reactome/R-HSA-5656105.md	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLI binding REV1 and PCNA.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	52	R-HSA-5656148	POLI incorporates dNMP	yes	reactome/R-HSA-5656148.md	POLI incorporates dNMP opposite to damaged DNA base	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLI nucleotide incorporation.
human	MAD2L2	genes/human/MAD2L2/MAD2L2-ai-review.yaml	MAD2L2	Q9UI95	NCBITaxon:9606	Homo sapiens	53	R-HSA-5656158	POLZ elongates POLI product	yes	reactome/R-HSA-5656158.md	POLZ elongates POLI-incorporated dNMP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for POLZ elongation of POLI product.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	10	R-HSA-5223345	Miscellaneous transport and binding events	yes	reactome/R-HSA-5223345.md	Miscellaneous transport and binding events	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Generic transmembrane-transport annotation propagated from the Reactome ""Miscellaneous transport and binding events"" pathway, itself based on the contested Mg2+-transporter model. Not the core function; mark as over-annotated."
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	16	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Correct core localization (Reactome ""Transfer of N-glycan to the protein""). Redundant with experimental and IEA annotations; accept."
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	17	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization, propagated via a Reactome viral-spike-glycosylation pathway (OST-B acts at the ER membrane). Redundant but correct; accept.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	18	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization, propagated via a Reactome flavivirus-glycosylation pathway. Redundant with other ER-membrane annotations; accept.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	19	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization, propagated via a Reactome viral-glycosylation pathway. Redundant with other ER-membrane annotations; accept.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	20	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core localization, propagated via a Reactome viral-protein-glycosylation pathway. Redundant with other ER-membrane annotations; accept.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	21	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Correct core localization, propagated via the Reactome ""CD274 N-linked glycosylation in ER"" pathway. Redundant with other ER-membrane annotations; accept."
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	24	R-HSA-5339538	MAGT1 transports Mg2+ from extracellular region to cytosol	yes	reactome/R-HSA-5339538.md	MAGT1 transports Mg2+ from extracellular region to cytosol	Homo sapiens	GO:0015095	magnesium ion transmembrane transporter activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Over-annotation. Reactome (""MAGT1 transports Mg2+ from extracellular region to cytosol"") encodes the historical direct-transporter model. The best-supported MF is the OST-B oxidoreductase activity; the direct Mg2+-transporter activity is contested and likely indirect. Mark as over-annotated."
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Non-core localization propagated from a Reactome neutrophil-degranulation pathway (""Exocytosis of azurophil granule membrane proteins""). MAGT1 was detected in neutrophil granule/membrane proteomics, but its characterized function is at the ER membrane as an OST-B subunit. Keep as non-core."
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	31	R-HSA-5339538	MAGT1 transports Mg2+ from extracellular region to cytosol	yes	reactome/R-HSA-5339538.md	MAGT1 transports Mg2+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Non-core localization from the Reactome Mg2+-transport reaction, encoding the historical plasma-membrane transporter model. The functionally relevant pool is the ER; keep as non-core.
human	MAGT1	genes/human/MAGT1/MAGT1-ai-review.yaml	MAGT1	Q9H0U3	NCBITaxon:9606	Homo sapiens	32	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Non-core plasma-membrane localization propagated from the Reactome neutrophil-degranulation pathway. Not the ER core; keep as non-core.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	27	R-HSA-1912394	NICD1 in complex with RBPJ (CSL) recruits MAML	yes	reactome/R-HSA-1912394.md	NICD1 in complex with RBPJ (CSL) recruits MAML	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of the NICD-RBPJ coactivator complex assembly reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	28	R-HSA-212356	Formation of CSL-NICD coactivator complex	yes	reactome/R-HSA-212356.md	Formation of CSL-NICD coactivator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	29	R-HSA-2197588	NICD2 binds RBPJ and MAML in the nucleus	yes	reactome/R-HSA-2197588.md	NICD2 binds RBPJ and MAML in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	30	R-HSA-2220957	NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC	yes	reactome/R-HSA-2220957.md	NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	31	R-HSA-2220964	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML	yes	reactome/R-HSA-2220964.md	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	32	R-HSA-2220971	CDK8 phosphorylates NICD1 PEST domain mutants	yes	reactome/R-HSA-2220971.md	CDK8 phosphorylates NICD1 PEST domain mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	33	R-HSA-2976742	NOTCH2 coactivator complex binds FCER2 promoter	yes	reactome/R-HSA-2976742.md	NOTCH2 coactivator complex binds FCER2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	34	R-HSA-4396371	NOTCH1 Coactivator Complex binds MYC promoter	yes	reactome/R-HSA-4396371.md	NOTCH1 Coactivator Complex binds MYC promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	35	R-HSA-4396379	NOTCH1 Coactivator Complex binds HES5 promoter	yes	reactome/R-HSA-4396379.md	NOTCH1 Coactivator Complex binds HES5 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	36	R-HSA-4396392	NOTCH1 PEST domain mutants bind HES1 promoter	yes	reactome/R-HSA-4396392.md	NOTCH1 PEST domain mutants bind HES1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	37	R-HSA-4396393	NOTCH1 PEST domain mutants bind MYC promoter	yes	reactome/R-HSA-4396393.md	NOTCH1 PEST domain mutants bind MYC promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	38	R-HSA-4396401	NOTCH1 PEST domain mutants bind HES5 promoter	yes	reactome/R-HSA-4396401.md	NOTCH1 PEST domain mutants bind HES5 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	39	R-HSA-4396402	NOTCH1 PEST domain mutants bind promoters of HEY genes	yes	reactome/R-HSA-4396402.md	NOTCH1 PEST domain mutants bind promoters of HEY genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	40	R-HSA-8878220	RUNX3 binds the NOTCH1 coactivator complex	yes	reactome/R-HSA-8878220.md	RUNX3 binds the NOTCH1 coactivator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	41	R-HSA-8878237	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	yes	reactome/R-HSA-8878237.md	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	42	R-HSA-9017835	NOTCH1 coactivator complex binds NOTCH3 gene	yes	reactome/R-HSA-9017835.md	NOTCH1 coactivator complex binds NOTCH3 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	43	R-HSA-9018542	NOTCH3 coactivator complex binds DLGAP5 gene promoter	yes	reactome/R-HSA-9018542.md	NOTCH3 coactivator complex binds DLGAP5 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	44	R-HSA-9021406	NOTCH3 coactivator complex binds PBX1 gene promoter	yes	reactome/R-HSA-9021406.md	NOTCH3 coactivator complex binds PBX1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	45	R-HSA-9021451	NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter	yes	reactome/R-HSA-9021451.md	NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	46	R-HSA-9021480	NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter	yes	reactome/R-HSA-9021480.md	NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	47	R-NUL-2064916	MAML recruits CDK8:CCNC to xNICD1	yes	reactome/R-NUL-2064916.md	MAML recruits CDK8:CCNC to xNICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	48	R-NUL-2065178	CDK8 phosphorylates xNICD1	yes	reactome/R-NUL-2065178.md	CDK8 phosphorylates xNICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	49	R-NUL-4396363	mNICD1 Chimeric Enhancer Complex binds Hes1 promoter	yes	reactome/R-NUL-4396363.md	mNICD1 Chimeric Enhancer Complex binds Hes1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	50	R-NUL-9013647	NICD3 binds RBPJ and MAML in the nucleus	yes	reactome/R-NUL-9013647.md	NICD3 binds RBPJ and MAML in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	51	R-NUL-9013660	Notch3 coactivator complex binds Hes1 gene promoter	yes	reactome/R-NUL-9013660.md	Notch3 coactivator complex binds Hes1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	52	R-NUL-9013699	NICD4 binds RBPJ and MAML in the nucleus	yes	reactome/R-NUL-9013699.md	NICD4 binds RBPJ and MAML in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAML1	genes/human/MAML1/MAML1-ai-review.yaml	MAML1	Q92585	NCBITaxon:9606	Homo sapiens	53	R-NUL-9604511	Notch4 binds FLT4 gene promoter	yes	reactome/R-NUL-9604511.md	Notch4 binds FLT4 gene promoter	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MAML in the nucleoplasm as part of a NICD-RBPJ-MAML Notch coactivator complex reaction.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	12	R-HSA-4793949	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)	yes	reactome/R-HSA-4793949.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 mannosidase activity (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	13	R-HSA-901024	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901024.md	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 hydrolysis of a 1,2-linked mannose (a branch).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	14	R-HSA-901036	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901036.md	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 hydrolysis of a second 1,2-linked mannose (a branch).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	15	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 hydrolysis of a 1,2-linked mannose (c branch).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	16	R-HSA-901074	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-901074.md	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1/EDEM2 hydrolysis of a 1,2-linked mannose (b branch).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	17	R-HSA-9036008	Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-9036008.md	Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 mannosidase activity (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	18	R-HSA-9036011	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-9036011.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 mannosidase activity (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	19	R-HSA-9036012	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)	yes	reactome/R-HSA-9036012.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 mannosidase activity (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	20	R-HSA-9696807	N-glycan mannose trimming of Spike	yes	reactome/R-HSA-9696807.md	N-glycan mannose trimming of Spike	Homo sapiens	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of MAN1B1 mannosidase activity in the context of N-glycan mannose trimming of viral (SARS-CoV-2) spike.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	26	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		ACCEPT	Reactome curation of ER mannose trimming in the ER Quality Control Compartment pathway.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	32	R-HSA-9694548	Maturation of spike protein	yes	reactome/R-HSA-9694548.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation of MAN1B1 in N-glycan mannose trimming of the SARS-CoV-2 spike glycoprotein. This is the generic mannosidase activity acting on a viral glycoprotein substrate, not a distinct viral function.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	33	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0036510	trimming of terminal mannose on C branch	TAS	involved_in	BP	false		ACCEPT	Reactome curation of the specific sub-step in which ERManI trims the terminal C-branch mannose; an accurate refinement of its trimming activity.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	42	R-HSA-4793949	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)	yes	reactome/R-HSA-4793949.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	43	R-HSA-9036008	Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-9036008.md	Defective MAN1B1 does not hydrolyse a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	44	R-HSA-9036011	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-9036011.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	45	R-HSA-9036012	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)	yes	reactome/R-HSA-9036012.md	Defective MAN1B1 does not hydrolyse 1,2-linked mannose (c branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization (defective-MAN1B1 reaction context).
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	47	R-HSA-901024	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901024.md	MAN1B1 hydrolyses 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	48	R-HSA-901036	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	yes	reactome/R-HSA-901036.md	MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	49	R-HSA-901039	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	yes	reactome/R-HSA-901039.md	MAN1B1 hydrolyses 1,2-linked mannose (c branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	50	R-HSA-901074	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	yes	reactome/R-HSA-901074.md	MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization.
human	MAN1B1	genes/human/MAN1B1/MAN1B1-ai-review.yaml	MAN1B1	Q9UKM7	NCBITaxon:9606	Homo sapiens	51	R-HSA-9696807	N-glycan mannose trimming of Spike	yes	reactome/R-HSA-9696807.md	N-glycan mannose trimming of Spike	Homo sapiens	GO:0044322	endoplasmic reticulum quality control compartment	TAS	located_in	CC	false		ACCEPT	Reactome curation of ERQC localization in the spike N-glycan trimming pathway.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	3	R-HSA-109862	MAP2K2 phosphorylates MAPK1	yes	reactome/R-HSA-109862.md	MAP2K2 phosphorylates MAPK1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		MODIFY	MEK2 phosphorylates both threonine and tyrosine in ERK activation loops; MAP kinase kinase activity is the informative function.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	101	R-HSA-109858	MAP2K2 binds MAPK1	yes	reactome/R-HSA-109858.md	MAP2K2 binds MAPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	102	R-HSA-109862	MAP2K2 phosphorylates MAPK1	yes	reactome/R-HSA-109862.md	MAP2K2 phosphorylates MAPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	103	R-HSA-109864	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2	yes	reactome/R-HSA-109864.md	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	104	R-HSA-5211356	Anthrax lef cleaves target cell MAP2K2 (MEK2)	yes	reactome/R-HSA-5211356.md	Anthrax lef cleaves target cell MAP2K2 (MEK2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	105	R-HSA-5672972	MAP2Ks and MAPKs bind to the activated RAF complex	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	106	R-HSA-5672973	MAP2Ks phosphorylate MAPKs	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	107	R-HSA-5672978	RAF phosphorylates MAP2K dimer	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	108	R-HSA-5672980	Dissociation of RAS:RAF complex	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	109	R-HSA-5674130	MAP2Ks and MAPKs are phosphorylated at the endosome membrane	yes	reactome/R-HSA-5674130.md	MAP2Ks and MAPKs are phosphorylated at the endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	110	R-HSA-5674132	WDR83:LAMTOR2:LAMTOR3 binds MAPK components	yes	reactome/R-HSA-5674132.md	WDR83:LAMTOR2:LAMTOR3 binds MAPK components	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	111	R-HSA-5674366	IL17RD binds p-2S MAP2Ks and MAPKs	yes	reactome/R-HSA-5674366.md	IL17RD binds p-2S MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	112	R-HSA-5674373	MAP2Ks phosphorylate MAPK at the Golgi membrane	yes	reactome/R-HSA-5674373.md	MAP2Ks phosphorylate MAPK at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	113	R-HSA-5674496	Activated MAPKs phosphorylate MAP2K1	yes	reactome/R-HSA-5674496.md	Activated MAPKs phosphorylate MAP2K1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	114	R-HSA-6802910	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants	yes	reactome/R-HSA-6802910.md	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	115	R-HSA-6802911	High kinase activity BRAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802911.md	High kinase activity BRAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	116	R-HSA-6802912	High kinase activity BRAF mutants bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802912.md	High kinase activity BRAF mutants bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	117	R-HSA-6802914	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	118	R-HSA-6802918	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	119	R-HSA-6802919	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	120	R-HSA-6802921	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	121	R-HSA-6802922	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	122	R-HSA-6802925	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	123	R-HSA-6802926	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	124	R-HSA-6802932	Dissociation of BRAF/RAF fusion complex	yes	reactome/R-HSA-6802932.md	Dissociation of BRAF/RAF fusion complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	125	R-HSA-6802933	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	yes	reactome/R-HSA-6802933.md	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	126	R-HSA-6802934	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802934.md	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	127	R-HSA-6802935	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	yes	reactome/R-HSA-6802935.md	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	128	R-HSA-6802942	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	129	R-HSA-6802943	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	130	R-HSA-6803227	Dissociation of high activity BRAF complexes	yes	reactome/R-HSA-6803227.md	Dissociation of high activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	131	R-HSA-6803230	Dissociation of moderate activity BRAF complexes	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	132	R-HSA-6803233	Dissociation of oncogenic RAS:RAF complex	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	133	R-HSA-6803234	Dissociation of paradoxically activated RAS:BRAF complexes	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	134	R-HSA-9610152	Activated BRAF recruits MAP2Ks and MAPKs to the endosome	yes	reactome/R-HSA-9610152.md	Activated BRAF recruits MAP2Ks and MAPKs to the endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	135	R-HSA-9610153	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF	yes	reactome/R-HSA-9610153.md	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	136	R-HSA-9610154	Dissociation of phosphorylated MAP2Ks and MAPKs	yes	reactome/R-HSA-9610154.md	Dissociation of phosphorylated MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	137	R-HSA-9610156	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF	yes	reactome/R-HSA-9610156.md	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	138	R-HSA-9652165	MAP2K mutants constitutively phosphorylate MAPKs	yes	reactome/R-HSA-9652165.md	MAP2K mutants constitutively phosphorylate MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	139	R-HSA-9656209	Dissociation of RAS:RAF1 mutant complex	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	140	R-HSA-9656211	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	141	R-HSA-9656214	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	142	R-HSA-9656215	RAF1 mutant complexes phosphorylate MAP2K dimer	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	143	R-HSA-9657599	Dual mechanism MAP2K inhibitors bind MAP2Ks	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	144	R-HSA-9657603	Dual mechanism MAPK inhibitors bind MAPKs	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	145	R-HSA-9657606	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	146	R-HSA-9657608	Single mechanism MAPK inhibitors bind phosphorylated MAPK	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic MEK2 is consistent with the characterized intracellular MAPK signaling complex.
human	MAP2K2	genes/human/MAP2K2/MAP2K2-ai-review.yaml	MAP2K2	P36507	NCBITaxon:9606	Homo sapiens	164	R-HSA-112411	MAPK1 (ERK2) activation	yes	reactome/R-HSA-112411.md	MAPK1 (ERK2) activation	Homo sapiens	GO:0070371	ERK1 and ERK2 cascade	TAS	involved_in	BP	false		ACCEPT	The ERK1/ERK2 cascade is the defining pathway for MEK2-mediated MAP kinase activation.
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	61	R-HSA-2559583	Cellular Senescence	yes	reactome/R-HSA-2559583.md	Cellular Senescence	Homo sapiens	GO:0090398	cellular senescence	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ASK1 is involved in cellular senescence via the oxidative stress induced senescence pathway. Recent research (2024) confirms ASK1 drives SASP via p38 during senescence. This is a legitimate biological process.
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	62	R-HSA-3228469	MAP3K5 phosphorylates MKK3 and MKK6	yes	reactome/R-HSA-3228469.md	MAP3K5 phosphorylates MKK3 and MKK6	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome pathway ""MAP3K5 phosphorylates MKK3 and MKK6."" This TAS annotation confirms kinase activity. Redundant with MAP3K activity."
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	63	R-NUL-3299417	MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)	yes	reactome/R-NUL-3299417.md	MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome pathway ""MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)."" Duplicate TAS annotation for kinase activity. Redundant with MAP3K activity."
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	92	R-HSA-3225851	ROS oxidize thioredoxin and activate MAP3K5	yes	reactome/R-HSA-3225851.md	ROS oxidize thioredoxin and activate MAP3K5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome pathway ""ROS oxidize thioredoxin and activate MAP3K5"" places ASK1 in cytosol. Acceptable localization annotation."
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	93	R-HSA-3228469	MAP3K5 phosphorylates MKK3 and MKK6	yes	reactome/R-HSA-3228469.md	MAP3K5 phosphorylates MKK3 and MKK6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway places ASK1 in cytosol. Duplicate acceptable.
human	MAP3K5	genes/human/MAP3K5/MAP3K5-ai-review.yaml	MAP3K5	Q99683	NCBITaxon:9606	Homo sapiens	94	R-NUL-3299417	MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)	yes	reactome/R-NUL-3299417.md	MAP3K5 (ASK1) phosphorylates Map2k4(Sek1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway places ASK1 in cytosol. Duplicate acceptable.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	106	R-HSA-111898	TODO: Fetch title	yes	reactome/R-HSA-111898.md	Phosphorylation of cPLA2 by ERK-2	Homo sapiens	GO:0004707	MAP kinase activity	TAS	enables	MF	false		ACCEPT	MAPK1/ERK2 has MAP kinase activity.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	107	R-HSA-445079	TODO: Fetch title	yes	reactome/R-HSA-445079.md	Phosphorylation of L1 by ERK	Homo sapiens	GO:0004707	MAP kinase activity	TAS	enables	MF	false		ACCEPT	MAPK1/ERK2 has MAP kinase activity.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	129	R-HSA-9652816	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	130	R-HSA-9636296	TODO: Fetch title	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This is not a supported core MAPK1 localization in this review.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	131	R-HSA-9635739	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	139	R-HSA-6798751	TODO: Fetch title	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This is not a supported core MAPK1 localization in this review.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	140	R-HSA-6800434	TODO: Fetch title	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This is not a supported core MAPK1 localization in this review.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	141	R-HSA-6798751	TODO: Fetch title	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This is not a supported core MAPK1 localization in this review.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	142	R-HSA-6800434	TODO: Fetch title	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This is not a supported core MAPK1 localization in this review.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	150	R-HSA-198746	TODO: Fetch title	yes	reactome/R-HSA-198746.md	ERK1/2/5 activate RSK1/2/3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	151	R-HSA-198756	TODO: Fetch title	yes	reactome/R-HSA-198756.md	ERK1/2 phosphorylates MSK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	152	R-HSA-199959	TODO: Fetch title	yes	reactome/R-HSA-199959.md	ERKs are inactivated by protein phosphatase 2A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	153	R-HSA-203797	TODO: Fetch title	yes	reactome/R-HSA-203797.md	ERKs are inactivated by dual-specific phosphatases (DUSPs)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	154	R-HSA-3132737	TODO: Fetch title	yes	reactome/R-HSA-3132737.md	MAPKs phosphorylate ETS1 and ETS2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	155	R-HSA-3857329	TODO: Fetch title	yes	reactome/R-HSA-3857329.md	MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	156	R-HSA-450325	TODO: Fetch title	yes	reactome/R-HSA-450325.md	c-FOS activation by phospho ERK1/2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	157	R-HSA-5674387	TODO: Fetch title	yes	reactome/R-HSA-5674387.md	Phosphorylated MAPKs translocate into the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	158	R-HSA-5675373	TODO: Fetch title	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	159	R-HSA-9032751	TODO: Fetch title	yes	reactome/R-HSA-9032751.md	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	160	R-HSA-9610166	TODO: Fetch title	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	161	R-HSA-9632910	TODO: Fetch title	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	162	R-HSA-9725030	TODO: Fetch title	yes	reactome/R-HSA-9725030.md	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	163	R-HSA-9765960	TODO: Fetch title	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	164	R-NUL-9009236	TODO: Fetch title	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 can accumulate in the nuclear compartment after stimulation; this is one of several Reactome reaction-level annotations placing ERK2 in the nucleoplasm.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	165	R-HSA-109858	TODO: Fetch title	yes	reactome/R-HSA-109858.md	MAP2K2 binds MAPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	166	R-HSA-109862	TODO: Fetch title	yes	reactome/R-HSA-109862.md	MAP2K2 phosphorylates MAPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	167	R-HSA-109864	TODO: Fetch title	yes	reactome/R-HSA-109864.md	Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	168	R-HSA-111898	TODO: Fetch title	yes	reactome/R-HSA-111898.md	Phosphorylation of cPLA2 by ERK-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	169	R-HSA-1168459	TODO: Fetch title	yes	reactome/R-HSA-1168459.md	Lyn activates ERK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	170	R-HSA-2029469	TODO: Fetch title	yes	reactome/R-HSA-2029469.md	p-ERK phosphorylates WAVEs and ABI	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	171	R-HSA-3371531	TODO: Fetch title	yes	reactome/R-HSA-3371531.md	Constitutive phosphorylation by pERK1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	172	R-HSA-418158	TODO: Fetch title	yes	reactome/R-HSA-418158.md	SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	173	R-HSA-418163	TODO: Fetch title	yes	reactome/R-HSA-418163.md	Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	174	R-HSA-418170	TODO: Fetch title	yes	reactome/R-HSA-418170.md	F2R:ARRB1 binds MAPKs, SRC-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	175	R-HSA-418176	TODO: Fetch title	yes	reactome/R-HSA-418176.md	F2R:ARRB2 binds MAPKs, SRC-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	176	R-HSA-418200	TODO: Fetch title	yes	reactome/R-HSA-418200.md	SRC-1 bound to ARRB2 is not activated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	177	R-HSA-445079	TODO: Fetch title	yes	reactome/R-HSA-445079.md	Phosphorylation of L1 by ERK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	178	R-HSA-5654560	TODO: Fetch title	yes	reactome/R-HSA-5654560.md	Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	179	R-HSA-5654562	TODO: Fetch title	yes	reactome/R-HSA-5654562.md	Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	180	R-HSA-5654565	TODO: Fetch title	yes	reactome/R-HSA-5654565.md	Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	181	R-HSA-5654566	TODO: Fetch title	yes	reactome/R-HSA-5654566.md	Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	182	R-HSA-5672972	TODO: Fetch title	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	183	R-HSA-5672973	TODO: Fetch title	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	184	R-HSA-5672978	TODO: Fetch title	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	185	R-HSA-5672980	TODO: Fetch title	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	186	R-HSA-5674130	TODO: Fetch title	yes	reactome/R-HSA-5674130.md	MAP2Ks and MAPKs are phosphorylated at the endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	187	R-HSA-5674132	TODO: Fetch title	yes	reactome/R-HSA-5674132.md	WDR83:LAMTOR2:LAMTOR3 binds MAPK components	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	188	R-HSA-5674366	TODO: Fetch title	yes	reactome/R-HSA-5674366.md	IL17RD binds p-2S MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	189	R-HSA-5674373	TODO: Fetch title	yes	reactome/R-HSA-5674373.md	MAP2Ks phosphorylate MAPK at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	190	R-HSA-5674385	TODO: Fetch title	yes	reactome/R-HSA-5674385.md	p-T,Y MAPKs dimerize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	191	R-HSA-5674387	TODO: Fetch title	yes	reactome/R-HSA-5674387.md	Phosphorylated MAPKs translocate into the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	192	R-HSA-5674496	TODO: Fetch title	yes	reactome/R-HSA-5674496.md	Activated MAPKs phosphorylate MAP2K1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	193	R-HSA-5675194	TODO: Fetch title	yes	reactome/R-HSA-5675194.md	Activated MAPK phosphorylates RAF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	194	R-HSA-5675198	TODO: Fetch title	yes	reactome/R-HSA-5675198.md	Activated MAPKs phosphorylate BRAF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	195	R-HSA-5675206	TODO: Fetch title	yes	reactome/R-HSA-5675206.md	PEA15 binds MAPK monomers and dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	196	R-HSA-5675376	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	197	R-HSA-6802910	TODO: Fetch title	yes	reactome/R-HSA-6802910.md	Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	198	R-HSA-6802911	TODO: Fetch title	yes	reactome/R-HSA-6802911.md	High kinase activity BRAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	199	R-HSA-6802912	TODO: Fetch title	yes	reactome/R-HSA-6802912.md	High kinase activity BRAF mutants bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	200	R-HSA-6802914	TODO: Fetch title	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	201	R-HSA-6802918	TODO: Fetch title	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	202	R-HSA-6802919	TODO: Fetch title	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	203	R-HSA-6802921	TODO: Fetch title	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	204	R-HSA-6802922	TODO: Fetch title	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	205	R-HSA-6802925	TODO: Fetch title	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	206	R-HSA-6802926	TODO: Fetch title	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	207	R-HSA-6802932	TODO: Fetch title	yes	reactome/R-HSA-6802932.md	Dissociation of BRAF/RAF fusion complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	208	R-HSA-6802933	TODO: Fetch title	yes	reactome/R-HSA-6802933.md	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	209	R-HSA-6802934	TODO: Fetch title	yes	reactome/R-HSA-6802934.md	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	210	R-HSA-6802935	TODO: Fetch title	yes	reactome/R-HSA-6802935.md	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	211	R-HSA-6802942	TODO: Fetch title	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	212	R-HSA-6802943	TODO: Fetch title	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	213	R-HSA-6803227	TODO: Fetch title	yes	reactome/R-HSA-6803227.md	Dissociation of high activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	214	R-HSA-6803230	TODO: Fetch title	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	215	R-HSA-6803233	TODO: Fetch title	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	216	R-HSA-6803234	TODO: Fetch title	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	217	R-HSA-6811454	TODO: Fetch title	yes	reactome/R-HSA-6811454.md	MAPKs phosphorylate PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	218	R-HSA-6811472	TODO: Fetch title	yes	reactome/R-HSA-6811472.md	IER3 recruits MAPKs to PP2A-B56-beta,gamma	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	219	R-HSA-9610152	TODO: Fetch title	yes	reactome/R-HSA-9610152.md	Activated BRAF recruits MAP2Ks and MAPKs to the endosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	220	R-HSA-9610153	TODO: Fetch title	yes	reactome/R-HSA-9610153.md	Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	221	R-HSA-9610154	TODO: Fetch title	yes	reactome/R-HSA-9610154.md	Dissociation of phosphorylated MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	222	R-HSA-9610156	TODO: Fetch title	yes	reactome/R-HSA-9610156.md	MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	223	R-HSA-9610166	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	224	R-HSA-9626832	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	225	R-HSA-9627089	TODO: Fetch title	yes	reactome/R-HSA-9627089.md	CASP9 is phosphorylated at T412	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	226	R-HSA-9632910	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	227	R-HSA-9635743	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	228	R-HSA-9636296	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	229	R-HSA-9652165	TODO: Fetch title	yes	reactome/R-HSA-9652165.md	MAP2K mutants constitutively phosphorylate MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	230	R-HSA-9656209	TODO: Fetch title	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	231	R-HSA-9656211	TODO: Fetch title	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	232	R-HSA-9656214	TODO: Fetch title	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	233	R-HSA-9656215	TODO: Fetch title	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	234	R-HSA-9657599	TODO: Fetch title	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	235	R-HSA-9657603	TODO: Fetch title	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	236	R-HSA-9657606	TODO: Fetch title	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	237	R-HSA-9657608	TODO: Fetch title	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	238	R-HSA-9731111	TODO: Fetch title	yes	reactome/R-HSA-9731111.md	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	239	R-HSA-9732753	TODO: Fetch title	yes	reactome/R-HSA-9732753.md	JAK1-activated RAF1 phosphorylates MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	240	R-HSA-9734547	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	241	R-HSA-9824582	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	242	R-HSA-9824977	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	243	R-HSA-9825759	TODO: Fetch title	yes	reactome/R-HSA-9825759.md	MAPK-dependent phosphorylation of KARS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	244	R-HSA-9845033	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPK1	genes/human/MAPK1/MAPK1-ai-review.yaml	MAPK1	P28482	NCBITaxon:9606	Homo sapiens	245	R-NUL-9619973	TODO: Fetch title	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MAPK1/ERK2 is present in the cytosolic/cytoplasmic compartment; this is one of many Reactome reaction-level annotations placing ERK2 in the cytosol.
human	MAPT	genes/human/MAPT/MAPT-ai-review.yaml	MAPT	P10636	NCBITaxon:9606	Homo sapiens	45	R-HSA-9836404	p-PKR dimer phosphorylates MAPT	yes	reactome/R-HSA-9836404.md	p-PKR dimer phosphorylates MAPT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
human	MAPT	genes/human/MAPT/MAPT-ai-review.yaml	MAPT	P10636	NCBITaxon:9606	Homo sapiens	62	R-NUL-9619534	AMPK phosphorylates Mapt	yes	reactome/R-NUL-9619534.md	AMPK phosphorylates Mapt	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
human	MAPT	genes/human/MAPT/MAPT-ai-review.yaml	MAPT	P10636	NCBITaxon:9606	Homo sapiens	63	R-NUL-9619539	AMPK-negatively regulates binding of MAPT to microtubules	yes	reactome/R-NUL-9619539.md	AMPK-negatively regulates binding of MAPT to microtubules	Bos taurus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
human	MAPT	genes/human/MAPT/MAPT-ai-review.yaml	MAPT	P10636	NCBITaxon:9606	Homo sapiens	177	R-HSA-201629	Caspase-mediated cleavage of Tau	yes	reactome/R-HSA-201629.md	Caspase-mediated cleavage of Tau	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is retained as a core cellular-component/localization annotation for MAPT; it captures site of action or component context within the synthesized core biology: tau microtubule binding, microtubule assembly/stability, axonal and neuronal projection localization, and phosphorylation-dependent regulation of tau behavior.
human	MASTL	genes/human/MASTL/MASTL-ai-review.yaml	MASTL	Q96GX5	NCBITaxon:9606	Homo sapiens	7	R-HSA-2168079	MASTL (GWL) phosphorylates ARPP19	yes	reactome/R-HSA-2168079.md	MASTL (GWL) phosphorylates ARPP19	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction in which MASTL phosphorylates ARPP19 on Ser62.
human	MASTL	genes/human/MASTL/MASTL-ai-review.yaml	MASTL	Q96GX5	NCBITaxon:9606	Homo sapiens	8	R-HSA-2430535	MASTL phosphorylates ENSA	yes	reactome/R-HSA-2430535.md	MASTL phosphorylates ENSA	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction in which MASTL phosphorylates ENSA on Ser67.
human	MASTL	genes/human/MASTL/MASTL-ai-review.yaml	MASTL	Q96GX5	NCBITaxon:9606	Homo sapiens	16	R-HSA-2168079	MASTL (GWL) phosphorylates ARPP19	yes	reactome/R-HSA-2168079.md	MASTL (GWL) phosphorylates ARPP19	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the MASTL-ARPP19 phosphorylation reaction in the nucleoplasm.
human	MASTL	genes/human/MASTL/MASTL-ai-review.yaml	MASTL	Q96GX5	NCBITaxon:9606	Homo sapiens	17	R-HSA-2430535	MASTL phosphorylates ENSA	yes	reactome/R-HSA-2430535.md	MASTL phosphorylates ENSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the MASTL-ENSA phosphorylation reaction in the nucleoplasm.
human	MASTL	genes/human/MASTL/MASTL-ai-review.yaml	MASTL	Q96GX5	NCBITaxon:9606	Homo sapiens	22	R-HSA-2465910	MASTL Facilitates Mitotic Progression	yes	reactome/R-HSA-2465910.md	MASTL Facilitates Mitotic Progression	Homo sapiens	GO:0007346	regulation of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome pathway 'MASTL Facilitates Mitotic Progression'.
human	MAT1A	genes/human/MAT1A/MAT1A-ai-review.yaml	MAT1A	Q00266	NCBITaxon:9606	Homo sapiens	22	R-HSA-5603087	Defective MAT1A does not transfer Ado from ATP to L-Met	yes	reactome/R-HSA-5603087.md	Defective MAT1A does not transfer Ado from ATP to L-Met	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localization to the cytosol (reaction: defective MAT1A does not transfer Ado from ATP to L-Met). Consistent with the cytosolic IBA annotation.
human	MAT1A	genes/human/MAT1A/MAT1A-ai-review.yaml	MAT1A	Q00266	NCBITaxon:9606	Homo sapiens	23	R-HSA-174391	MAT1A multimers transfer Ado from ATP to L-Met	yes	reactome/R-HSA-174391.md	MAT1A multimers transfer Ado from ATP to L-Met	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the cytosol (reaction: MAT1A multimers transfer Ado from ATP to L-Met). Duplicates the cytosol annotation for the SAM-synthesis reaction.
human	MAT1A	genes/human/MAT1A/MAT1A-ai-review.yaml	MAT1A	Q00266	NCBITaxon:9606	Homo sapiens	24	R-HSA-2408551	SeMet is converted to AdoSeMet by MAT	yes	reactome/R-HSA-2408551.md	SeMet is converted to AdoSeMet by MAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the cytosol (reaction: SeMet is converted to AdoSeMet by MAT). Reflects the cytosolic MAT activity acting on the selenomethionine analogue.
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	61	R-HSA-166721	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa	yes	reactome/R-HSA-166721.md	MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	62	R-HSA-166726	Activation of MASPs	yes	reactome/R-HSA-166726.md	Activation of MASPs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	63	R-HSA-166753	Conversion of C4 into C4a and C4b	yes	reactome/R-HSA-166753.md	Conversion of C4 into C4a and C4b	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	64	R-HSA-166792	Conversion of C2 into C2a and C2b	yes	reactome/R-HSA-166792.md	Conversion of C2 into C2a and C2b	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	65	R-HSA-9758529	SARS-CoV-2 N binds MASP2	yes	reactome/R-HSA-9758529.md	SARS-CoV-2 N binds MASP2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	66	R-HSA-9921544	NS1 binds MBL	yes	reactome/R-HSA-9921544.md	NS1 binds MBL	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MBL2	genes/human/MBL2/MBL2-ai-review.yaml	MBL2	P11226	NCBITaxon:9606	Homo sapiens	67	R-HSA-9957161	MBL2 binds SARS-CoV-2 S	yes	reactome/R-HSA-9957161.md	MBL2 binds SARS-CoV-2 S	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Correct secreted extracellular location (Reactome lectin-pathway/recognition reaction).
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	20	R-HSA-9909466	MCCC mutants don't synthesize beta-methylglutaconyl-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC1 in the mitochondrial matrix, consistent with all other localization evidence.
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	34	R-HSA-3065959	An unknown protease degrades hCBXs	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC1 in the mitochondrial matrix (protein degradation reaction context).
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	35	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC1 in the mitochondrial matrix.
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	36	R-HSA-508308	beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC1 in the mitochondrial matrix (carboxylation reaction context).
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	37	R-HSA-70773	beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC1 in the mitochondrial matrix (carboxylation reaction context).
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	38	R-HSA-2993799	HLCS biotinylates 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome models newly translated carboxylase subunits transiently in the cytosol before mitochondrial import (HLCS biotinylation / translocation reactions). MCCC1 is not a steady-state cytosolic protein; its mature functional location is the mitochondrial matrix.
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	39	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome cytosolic annotation reflecting the pre-import translocation step (cytosolic carboxylases translocate to mitochondrial matrix), not a functional steady-state cytosolic location.
human	MCCC1	genes/human/MCCC1/MCCC1-ai-review.yaml	MCCC1	Q96RQ3	NCBITaxon:9606	Homo sapiens	40	R-HSA-9035987	Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome cytosolic annotation from the defective-HLCS biotinylation reaction, representing the transient pre-import state rather than a functional cytosolic localization.
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	22	R-HSA-9909466	MCCC mutants don't synthesize beta-methylglutaconyl-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing MCCC2 in the mitochondrial matrix (context of the 3-MCC deficiency pathway).
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	32	R-HSA-3065959	An unknown protease degrades hCBXs	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MCCC2 in the mitochondrial matrix (carboxylase degradation reaction context).
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	33	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MCCC2 in the mitochondrial matrix.
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	34	R-HSA-508308	beta-methylglutaconyl-CoA + ADP + orthophosphate <=> beta-methylcrotonyl-CoA + ATP + HCO3- (MCCA)	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MCCC2 in the mitochondrial matrix (carboxylation reaction context).
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	35	R-HSA-70773	beta-methylcrotonyl-CoA + ATP + HCO3- <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O (MCCA)	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MCCC2 in the mitochondrial matrix (MCC reaction context).
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	36	R-HSA-2993799	HLCS biotinylates 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotating MCCC2 to the cytosol, arising from the modeled HLCS-mediated biotinylation / cytosol-to-matrix translocation steps of the nascent carboxylase rather than a steady-state functional location.
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	37	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotating MCCC2 to the cytosol, from the modeled translocation of cytosolic (apo) carboxylases to the mitochondrial matrix.
human	MCCC2	genes/human/MCCC2/MCCC2-ai-review.yaml	MCCC2	Q9HCC0	NCBITaxon:9606	Homo sapiens	38	R-HSA-9035987	Defective HLCS does not biotinylate 6xMCCC1:6xMCCC2	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotating MCCC2 to the cytosol, in the context of defective HLCS failing to biotinylate the cytosolic apo-carboxylase.
human	MCEE	genes/human/MCEE/MCEE-ai-review.yaml	MCEE	Q96PE7	NCBITaxon:9606	Homo sapiens	9	R-HSA-71032	Propionyl-CoA catabolism	no				GO:0019626	short-chain fatty acid catabolic process	TAS	involved_in	BP	false		ACCEPT	Author-asserted (Reactome) involvement in propionyl-CoA catabolism, annotated to the short-chain fatty acid catabolic process parent.
human	MCEE	genes/human/MCEE/MCEE-ai-review.yaml	MCEE	Q96PE7	NCBITaxon:9606	Homo sapiens	10	R-HSA-71020	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA	no				GO:0004493	methylmalonyl-CoA epimerase activity	TAS	enables	MF	false		ACCEPT	Author-asserted (Reactome) epimerase molecular function.
human	MCEE	genes/human/MCEE/MCEE-ai-review.yaml	MCEE	Q96PE7	NCBITaxon:9606	Homo sapiens	14	R-HSA-71020	D-methylmalonyl-CoA <=> L-methylmalonyl-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Author-asserted (Reactome) localisation to the mitochondrial matrix.
human	MDH1	genes/human/MDH1/MDH1-ai-review.yaml	MDH1	P40925	NCBITaxon:9606	Homo sapiens	17	R-HSA-9856872	Malate-aspartate shuttle	yes	reactome/R-HSA-9856872.md	Malate-aspartate shuttle	Homo sapiens	GO:0043490	malate-aspartate shuttle	TAS	involved_in	BP	false		ACCEPT	Core biological process, from the Reactome malate-aspartate shuttle pathway in which MDH1 reduces oxaloacetate to malate as the cytosolic arm. Consistent with the IBA and IMP annotations to the same term.
human	MDH1	genes/human/MDH1/MDH1-ai-review.yaml	MDH1	P40925	NCBITaxon:9606	Homo sapiens	28	R-HSA-9856871	MDH1 reduces OA	yes	reactome/R-HSA-9856871.md	MDH1 reduces OA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic localization asserted by the Reactome ""MDH1 reduces OA"" reaction. Core cellular location, redundant with the IDA/IBA cytosol annotations."
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	16	R-HSA-71403	Citric acid cycle (TCA cycle)	yes	reactome/R-HSA-71403.md	Citric acid cycle (TCA cycle)	Homo sapiens	GO:0006099	tricarboxylic acid cycle	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing MDH2 in the citric acid (TCA) cycle. Core biological process; consistent with all other evidence.
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	17	R-HSA-9856872	Malate-aspartate shuttle	yes	reactome/R-HSA-9856872.md	Malate-aspartate shuttle	Homo sapiens	GO:0043490	malate-aspartate shuttle	TAS	involved_in	BP	false		ACCEPT	Reactome TAS placing MDH2 in the malate-aspartate shuttle, the mitochondrial arm of which is catalyzed by MDH2 (malate to oxaloacetate). Core biological process; also supported by IMP (PMID:37647199).
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	27	R-HSA-70979	MDH2 dimer dehydrogenates MAL	yes	reactome/R-HSA-70979.md	MDH2 dimer dehydrogenates MAL	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS (reaction ""MDH2 dimer dehydrogenates MAL"") placing the active enzyme in the mitochondrial matrix. Core location."
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	28	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (mitochondrial protein-degradation pathway; CLPXP binds matrix proteins) locating MDH2 in the mitochondrial matrix. Correct core location, captured here as a substrate of the matrix quality-control machinery.
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	29	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (LONP1 degrades matrix proteins) locating MDH2 in the mitochondrial matrix. Correct core location.
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	30	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (LONP1 binds matrix proteins) locating MDH2 in the mitochondrial matrix. Correct core location.
human	MDH2	genes/human/MDH2/MDH2-ai-review.yaml	MDH2	P40926	NCBITaxon:9606	Homo sapiens	31	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS (CLPXP degrades matrix proteins) locating MDH2 in the mitochondrial matrix. Correct core location.
human	MED13L	genes/human/MED13L/MED13L-ai-review.yaml	MED13L	Q71F56	NCBITaxon:9606	Homo sapiens	8	R-HSA-9836857	NS1 (1C) binds to Mediator complex	yes	reactome/R-HSA-9836857.md	NS1 (1C) binds to Mediator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	The nucleoplasm localization is consistent with MED13L's role in the Mediator complex, which functions in the nucleoplasm to regulate RNA polymerase II transcription.
human	MEFV	genes/human/MEFV/MEFV-ai-review.yaml	MEFV	O15553	NCBITaxon:9606	Homo sapiens	43	R-HSA-877361	Pyrin binds ASC	yes	reactome/R-HSA-877361.md	Pyrin binds ASC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (Pyrin binds ASC). Consistent with the core cytosolic site of inflammasome assembly.
human	MEFV	genes/human/MEFV/MEFV-ai-review.yaml	MEFV	O15553	NCBITaxon:9606	Homo sapiens	44	R-HSA-879221	PSTPIP1 binds Pyrin	yes	reactome/R-HSA-879221.md	PSTPIP1 binds Pyrin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (PSTPIP1 binds Pyrin). Consistent with the core cytosolic site of action.
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	10	R-HSA-964768	Addition of GlcNAc to the glycan on the A arm	yes	reactome/R-HSA-964768.md	Addition of GlcNAc to the glycan on the A arm	Homo sapiens	GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable annotation for the reaction ""Addition of GlcNAc to the glycan on the A arm"", described as the first committed step in complex/hybrid N-glycan synthesis. Exactly the core GlcNAc-TI activity. Accept."
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	12	R-HSA-9683686	Maturation of spike protein	yes	reactome/R-HSA-9683686.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation placing MGAT1 in SARS-CoV spike-protein maturation, where it performs its normal N-glycan branching on a viral glycoprotein substrate. This is the housekeeping GlcNAc-TI activity applied to a viral substrate rather than a dedicated antiviral/viral-processing function of MGAT1; keep but not core.
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	13	R-HSA-9694548	Maturation of spike protein	yes	reactome/R-HSA-9694548.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Duplicate Reactome ""Maturation of spike protein"" annotation (different stable ID). Same interpretation as the other viral protein processing annotation: substrate application of the normal Golgi N-glycan branching activity, not a core viral function."
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	14	R-HSA-9683648	Spike trimer glycoside chains are extended	yes	reactome/R-HSA-9683648.md	Spike trimer glycoside chains are extended	Homo sapiens	GO:0008375	acetylglucosaminyltransferase activity	TAS	enables	MF	false		MODIFY	"Reactome MF annotation from ""Spike trimer glycoside chains are extended"", which states GlcNAc-TI (MGAT1) adds a GlcNAc residue to high-mannose chains. Correct direction but over-general; the specific GlcNAc-TI term GO:0003827 captures the activity."
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	15	R-HSA-9694656	Spike trimer glycoside chains are extended	yes	reactome/R-HSA-9694656.md	Spike trimer glycoside chains are extended	Homo sapiens	GO:0008375	acetylglucosaminyltransferase activity	TAS	enables	MF	false		MODIFY	"Duplicate Reactome ""Spike trimer glycoside chains are extended"" MF annotation. Same over-general issue; replace with the specific GlcNAc-TI activity term."
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	16	R-HSA-964768	Addition of GlcNAc to the glycan on the A arm	yes	reactome/R-HSA-964768.md	Addition of GlcNAc to the glycan on the A arm	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the GlcNAc-TI reaction at the ERGIC membrane. The best-supported experimental location is the medial-Golgi membrane (IDA, PMID:20378551); an ERGIC pool is biologically plausible for an early secretory-pathway glycosyltransferase but is secondary to the Golgi location. Keep as non-core.
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	17	R-HSA-9683648	Spike trimer glycoside chains are extended	yes	reactome/R-HSA-9683648.md	Spike trimer glycoside chains are extended	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate ERGIC-membrane location from the viral spike Reactome reaction. Same interpretation: plausible secondary secretory-pathway location, secondary to the experimentally supported Golgi membrane. Keep as non-core.
human	MGAT1	genes/human/MGAT1/MGAT1-ai-review.yaml	MGAT1	P26572	NCBITaxon:9606	Homo sapiens	18	R-HSA-9694656	Spike trimer glycoside chains are extended	yes	reactome/R-HSA-9694656.md	Spike trimer glycoside chains are extended	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate ERGIC-membrane location (third Reactome stable ID). Keep as a plausible secondary location; the core compartment is the Golgi membrane.
human	MICU1	genes/human/MICU1/MICU1-ai-review.yaml	MICU1	Q9BPX6	NCBITaxon:9606	Homo sapiens	86	R-HSA-8949178	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix	yes	reactome/R-HSA-8949178.md	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	MICU1 is associated with the mitochondrial inner membrane, where it docks onto the MCU/EMRE pore.
human	MICU1	genes/human/MICU1/MICU1-ai-review.yaml	MICU1	Q9BPX6	NCBITaxon:9606	Homo sapiens	87	R-HSA-8953461	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex	yes	reactome/R-HSA-8953461.md	SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	MICU1 is associated with the mitochondrial inner membrane, where it docks onto the MCU/EMRE pore.
human	MKRN1	genes/human/MKRN1/MKRN1-ai-review.yaml	MKRN1	Q9UHC7	NCBITaxon:9606	Homo sapiens	9	R-HSA-8948775	Reactome pathway annotation (MKRN1 ubiquitin ligase activity)	yes	reactome/R-HSA-8948775.md	MKRN1 polyubiquitinates PTEN	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation of the core E3 ligase MF. Supported.
human	MKRN1	genes/human/MKRN1/MKRN1-ai-review.yaml	MKRN1	Q9UHC7	NCBITaxon:9606	Homo sapiens	11	R-HSA-8948757	Reactome pathway annotation (cytosol localization)	yes	reactome/R-HSA-8948757.md	AKT phosphorylates MKRN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization. Consistent with MKRN1's cytoplasmic E3 ligase and ribosome- associated functions.
human	MKRN1	genes/human/MKRN1/MKRN1-ai-review.yaml	MKRN1	Q9UHC7	NCBITaxon:9606	Homo sapiens	12	R-HSA-8948775	Reactome pathway annotation (MKRN1 ubiquitin ligase activity)	yes	reactome/R-HSA-8948775.md	MKRN1 polyubiquitinates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol localization (Reactome TAS). Supported.
human	MLEC	genes/human/MLEC/MLEC-ai-review.yaml	MLEC	Q14165	NCBITaxon:9606	Homo sapiens	9	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway for exocytosis of specific granule membrane proteins. This annotation suggests malectin is found at the plasma membrane.
human	MLEC	genes/human/MLEC/MLEC-ai-review.yaml	MLEC	Q14165	NCBITaxon:9606	Homo sapiens	10	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome indicating malectin is found in neutrophil-specific granule membranes.
human	MLEC	genes/human/MLEC/MLEC-ai-review.yaml	MLEC	Q14165	NCBITaxon:9606	Homo sapiens	13	R-HSA-532667	Removal of the second glucose by glucosidase II	yes	reactome/R-HSA-532667.md	Removal of the second glucose by glucosidase II	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for N-glycan trimming/removal of second glucose by glucosidase II.
human	MLEC	genes/human/MLEC/MLEC-ai-review.yaml	MLEC	Q14165	NCBITaxon:9606	Homo sapiens	14	R-HSA-901006	Binding of Malectin	yes	reactome/R-HSA-901006.md	Binding of Malectin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway specifically about malectin binding in the ER.
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	10	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing MMAA in cobalamin (vitamin B12) metabolism. MMAA is required for intracellular handling of B12, specifically the mitochondrial delivery and maintenance of the AdoCbl cofactor on MMUT.
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	13	R-HSA-3159259	MMAA:MUT binds AdoCbl	no				GO:0140104	molecular carrier activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS (""MMAA:MUT binds AdoCbl"") assigning molecular carrier activity. MMAA does not itself carry cobalamin as cargo; it is the G-protein that gates the transfer of AdoCbl (produced by MMAB) onto MMUT in a GTP-dependent manner. ""Molecular carrier activity"" mislabels the gating/regulatory GTPase role as direct cofactor transport."
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	30	R-HSA-3322135	Defective MMAA does not protect MUT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS placing MMAA in the mitochondrial matrix (the ""Defective MMAA does not protect MUT"" reaction). This is the specific compartment where MMAA acts on MMUT."
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	31	R-HSA-3159259	MMAA:MUT binds AdoCbl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS placing MMAA in the mitochondrial matrix (the ""MMAA:MUT binds AdoCbl"" reaction). Correct core functional location."
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	32	R-HSA-3322971	Defective MUT does not isomerise L-MM-CoA to SUCC-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MMAA in the mitochondrial matrix. Consistent with its functional compartment.
human	MMAA	genes/human/MMAA/MMAA-ai-review.yaml	MMAA	Q8IVH4	NCBITaxon:9606	Homo sapiens	33	R-HSA-71010	MUT isomerises L-MM-CoA to SUCC-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MMAA in the mitochondrial matrix (associated with the MUT isomerization reaction module). Consistent with the functional compartment.
human	MMAB	genes/human/MMAB/MMAB-ai-review.yaml	MMAB	Q96EY8	NCBITaxon:9606	Homo sapiens	9	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome-curated involvement of MMAB in cobalamin metabolism, reflecting its role in the AdoCbl branch of the intracellular cobalamin trafficking/processing pathway.
human	MMAB	genes/human/MMAB/MMAB-ai-review.yaml	MMAB	Q96EY8	NCBITaxon:9606	Homo sapiens	13	R-HSA-3322125	Defective MMAB does not transfer adenosyl group from ATP to B12s	no				GO:0008817	corrinoid adenosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-curated corrinoid adenosyltransferase activity of MMAB, corresponding to the reaction MMAB adenosylates cob(I)alamin. Consistent with all experimental evidence.
human	MMAB	genes/human/MMAB/MMAB-ai-review.yaml	MMAB	Q96EY8	NCBITaxon:9606	Homo sapiens	20	R-HSA-3322125	Defective MMAB does not transfer adenosyl group from ATP to B12s	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-curated mitochondrial matrix localization for MMAB, the compartment where AdoCbl is synthesized and delivered to methylmalonyl-CoA mutase.
human	MMAB	genes/human/MMAB/MMAB-ai-review.yaml	MMAB	Q96EY8	NCBITaxon:9606	Homo sapiens	21	R-HSA-3159253	MMAB adenosylates cob(I)alamin	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-curated mitochondrial matrix localization (from the MMAB adenosylates cob(I)alamin reaction). Duplicate compartment assignment; correct.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	11	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing MMACHC in cobalamin metabolism. Concordant with the core biological role and with the IDA/IBA cobalamin-metabolic-process annotations.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	12	R-HSA-3149519	MMACHC decyanates CNCbl	no				GO:0033787	cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the ""MMACHC decyanates CNCbl"" reaction, annotated to cyanocobalamin reductase activity. Matches the directly demonstrated decyanation function."
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	38	R-HSA-3318576	Defective MMACHC does not reduce Cbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localizing MMACHC to the cytosol (in the ""Defective MMACHC does not reduce Cbl"" reaction context). Consistent with the experimentally established cytosolic localization."
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	39	R-HSA-3318590	Defective MMACHC does not decyanate CNCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS cytosol annotation (in the ""Defective MMACHC does not decyanate CNCbl"" reaction context). Consistent with the established cytosolic localization."
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	40	R-HSA-3095889	MMACHC dealkylates RCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (MMACHC dealkylates RCbl reaction context). Consistent with the established cytosolic localization.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	41	R-HSA-3149494	MMACHC:cob(II)alamin binds MMADHC	yes	reactome/R-HSA-3149494.md	MMACHC:cob(II)alamin binds MMADHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (MMACHC:cob(II)alamin binds MMADHC reaction context). Consistent with the established cytosolic localization.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	42	R-HSA-3149519	MMACHC decyanates CNCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (MMACHC decyanates CNCbl reaction context). Consistent with the established cytosolic localization.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	43	R-HSA-3149563	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	yes	reactome/R-HSA-3149563.md	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (MMADHC targets transport of cytosolic cob(II)alamin to mitochondria reaction context). Consistent with the established cytosolic localization of MMACHC.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	44	R-HSA-3204318	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	yes	reactome/R-HSA-3204318.md	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (cob(II)alamin transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR reaction context). Consistent with the established cytosolic localization.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	45	R-HSA-3318571	Defective MMADHC does not bind MMACHC:B12r	yes	reactome/R-HSA-3318571.md	Defective MMADHC does not bind MMACHC:B12r	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (Defective MMADHC does not bind MMACHC:B12r reaction context). Consistent with the established cytosolic localization.
human	MMACHC	genes/human/MMACHC/MMACHC-ai-review.yaml	MMACHC	Q9Y4U1	NCBITaxon:9606	Homo sapiens	46	R-HSA-9759549	Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin reaction context). Consistent with the established cytosolic localization.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	8	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation (Cobalamin metabolism) placing MMADHC in cobalamin metabolic process. Consistent with all other evidence for this gene.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	10	R-HSA-3149563	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	yes	reactome/R-HSA-3149563.md	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	Homo sapiens	GO:0140104	molecular carrier activity	TAS	enables	MF	false		ACCEPT	Reactome TAS annotation (MMADHC targets transport of cytosolic cob(II)alamin to mitochondria) to molecular carrier activity, capturing MMADHC's cobalamin carrier/routing role.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	23	R-HSA-3318571	Defective MMADHC does not bind MMACHC:B12r	yes	reactome/R-HSA-3318571.md	Defective MMADHC does not bind MMACHC:B12r	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation localizing MMADHC to the cytosol, consistent with the experimental cytosolic localization and its cytosolic branch-point function.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	24	R-HSA-3149494	MMACHC:cob(II)alamin binds MMADHC	yes	reactome/R-HSA-3149494.md	MMACHC:cob(II)alamin binds MMADHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (MMACHC:cob(II)alamin binds MMADHC) localizing MMADHC to the cytosol, the compartment where it receives cobalamin from MMACHC.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	25	R-HSA-3149563	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	yes	reactome/R-HSA-3149563.md	MMADHC targets transport of cytosolic cob(II)alamin to mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation localizing MMADHC to the cytosol, matching the experimental cytosolic localization and function.
human	MMADHC	genes/human/MMADHC/MMADHC-ai-review.yaml	MMADHC	Q9H3L0	NCBITaxon:9606	Homo sapiens	26	R-HSA-3204318	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	yes	reactome/R-HSA-3204318.md	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (cob(II)alamin transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR) localizing MMADHC to the cytosol, consistent with its cytosolic cobalamin-handoff role within the MMACHC/MTR/MTRR complex.
human	MMUT	genes/human/MMUT/MMUT-ai-review.yaml	MMUT	P22033	NCBITaxon:9606	Homo sapiens	27	R-HSA-3322971	Defective MUT does not isomerise L-MM-CoA to SUCC-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (TAS) placing MMUT in the mitochondrial matrix (in the context of defective MUT failing to isomerise L-MM-CoA to succinyl-CoA). Correct localization.
human	MMUT	genes/human/MMUT/MMUT-ai-review.yaml	MMUT	P22033	NCBITaxon:9606	Homo sapiens	49	R-HSA-3159259	MMAA:MUT binds AdoCbl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MMUT in the mitochondrial matrix (MMAA:MUT binds AdoCbl reaction). Correct localization.
human	MMUT	genes/human/MMUT/MMUT-ai-review.yaml	MMUT	P22033	NCBITaxon:9606	Homo sapiens	50	R-HSA-3322135	Defective MMAA does not protect MUT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MMUT in the mitochondrial matrix (Defective MMAA does not protect MUT reaction). Correct localization.
human	MMUT	genes/human/MMUT/MMUT-ai-review.yaml	MMUT	P22033	NCBITaxon:9606	Homo sapiens	51	R-HSA-71010	MUT isomerises L-MM-CoA to SUCC-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing MMUT in the mitochondrial matrix (MUT isomerises L-MM-CoA to SUCC-CoA reaction). Correct localization for the catalytic step.
human	MOCOS	genes/human/MOCOS/MOCOS-ai-review.yaml	MOCOS	Q96EN8	NCBITaxon:9606	Homo sapiens	15	R-HSA-947581	Molybdenum cofactor biosynthesis	yes	reactome/R-HSA-947581.md	Molybdenum cofactor biosynthesis	Homo sapiens	GO:0032324	molybdopterin cofactor biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS to molybdopterin cofactor biosynthetic process (MoCo biosynthesis pathway). Correct but a general relative of the specific GO:0006777; kept as non-core.
human	MOCOS	genes/human/MOCOS/MOCOS-ai-review.yaml	MOCOS	Q96EN8	NCBITaxon:9606	Homo sapiens	16	R-HSA-947499	Exchange of oxygen with sulfur in MoCo	yes	reactome/R-HSA-947499.md	Exchange of oxygen with sulfur in MoCo	Homo sapiens	GO:0008265	molybdenum cofactor sulfurtransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the MoCo oxygen-to-sulfur exchange reaction, the core sulfurtransferase activity of MOCOS. Accepted; corroborates the experimental annotations to this term.
human	MOCOS	genes/human/MOCOS/MOCOS-ai-review.yaml	MOCOS	Q96EN8	NCBITaxon:9606	Homo sapiens	19	R-HSA-947499	Exchange of oxygen with sulfur in MoCo	yes	reactome/R-HSA-947499.md	Exchange of oxygen with sulfur in MoCo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome TAS), consistent with MoCo biosynthesis and MoCo sulfuration occurring in the cytosol in humans. Accepted as the core cellular location.
human	MOCS1	genes/human/MOCS1/MOCS1-ai-review.yaml	MOCS1	Q9NZB8	NCBITaxon:9606	Homo sapiens	25	R-HSA-947535	Cyclisation of GTP to precursor Z	yes	reactome/R-HSA-947535.md	Cyclisation of GTP to precursor Z	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) places the GTP-to-precursor-Z reaction in the cytosol. This predates the demonstration (PMID:31996372) that the mature catalytic MOCS1A/MOCS1B proteins act in the mitochondrial matrix; consistent with the cytosolic splice variants. Kept as non-core.
human	MOCS2	genes/human/MOCS2/MOCS2-ai-review.yaml	MOCS2	O96007	NCBITaxon:9606	Homo sapiens	10	R-HSA-947541	Sulfhydrylation and ring cleavage of precursor Z	yes	reactome/R-HSA-947541.md	Sulfhydrylation and ring cleavage of precursor Z	Homo sapiens	GO:0030366	molybdopterin synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author-statement for the core catalytic activity (sulfhydrylation and ring cleavage of precursor Z by the MOCS2B half of the tetramer). Accurate.
human	MOCS2	genes/human/MOCS2/MOCS2-ai-review.yaml	MOCS2	O96007	NCBITaxon:9606	Homo sapiens	24	R-HSA-947581	Molybdenum cofactor biosynthesis	yes	reactome/R-HSA-947581.md	Molybdenum cofactor biosynthesis	Homo sapiens	GO:0032324	molybdopterin cofactor biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS to the broader molybdopterin-cofactor biosynthesis term. Valid but less specific than GO:0006777.
human	MOCS2	genes/human/MOCS2/MOCS2-ai-review.yaml	MOCS2	O96007	NCBITaxon:9606	Homo sapiens	25	R-HSA-947541	Sulfhydrylation and ring cleavage of precursor Z	yes	reactome/R-HSA-947541.md	Sulfhydrylation and ring cleavage of precursor Z	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS for cytosolic localization. Consistent with the established cytosolic site of MPT synthase.
human	MOCS3	genes/human/MOCS3/MOCS3-ai-review.yaml	MOCS3	O95396	NCBITaxon:9606	Homo sapiens	38	R-HSA-947514	PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3	yes	reactome/R-HSA-947514.md	PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement for the cytosolic NFS1-to-MOCS3 sulfur transfer reaction. Consistent with the experimentally established cytosolic localization.
human	MOCS3	genes/human/MOCS3/MOCS3-ai-review.yaml	MOCS3	O95396	NCBITaxon:9606	Homo sapiens	39	R-HSA-947538	Transfer of sulfur from MOCS3-S-S onto MOCS2A	yes	reactome/R-HSA-947538.md	Transfer of sulfur from MOCS3-S-S onto MOCS2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement for the cytosolic MOCS3-to-MOCS2A sulfur transfer reaction. Consistent with the experimentally established cytosolic localization.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	9	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS placing MSMO1 in cholesterol biosynthesis (Bloch pathway via desmosterol). MSMO1's C4-demethylation is a required step of cholesterol synthesis.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	12	R-HSA-194641	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol	yes	reactome/R-HSA-194641.md	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol	Homo sapiens	GO:0000254	C-4 methylsterol oxidase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for C-4 methylsterol oxidase activity, describing the SC4MOL-catalyzed oxidation of 4,4-dimethylcholesta-8(9),24-dien-3beta-ol in the ER.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	13	R-HSA-6807062	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	yes	reactome/R-HSA-6807062.md	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS placing MSMO1 in cholesterol biosynthesis (Kandutsch-Russell / lathosterol pathway), the skin-prominent route to cholesterol.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	14	R-HSA-194641	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol	yes	reactome/R-HSA-194641.md	4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER-membrane localization, consistent with the curated subcellular location.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	15	R-HSA-194669	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol	yes	reactome/R-HSA-194669.md	4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER-membrane localization (second demethylation reaction), consistent with the curated subcellular location.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	16	R-HSA-9947203	MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol	yes	reactome/R-HSA-9947203.md	MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER-membrane localization (MSMO1 oxidation reaction), consistent with the curated subcellular location.
human	MSMO1	genes/human/MSMO1/MSMO1-ai-review.yaml	MSMO1	Q15800	NCBITaxon:9606	Homo sapiens	17	R-HSA-9947207	MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol	yes	reactome/R-HSA-9947207.md	MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for ER-membrane localization (MSMO1 oxidation reaction), consistent with the curated subcellular location.
human	MTHFD1	genes/human/MTHFD1/MTHFD1-ai-review.yaml	MTHFD1	P11586	NCBITaxon:9606	Homo sapiens	51	R-HSA-200644	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+	yes	reactome/R-HSA-200644.md	5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization for the dehydrogenase reaction; correct core location.
human	MTHFD1	genes/human/MTHFD1/MTHFD1-ai-review.yaml	MTHFD1	P11586	NCBITaxon:9606	Homo sapiens	52	R-HSA-200661	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG	yes	reactome/R-HSA-200661.md	MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization; correct core location.
human	MTHFD1	genes/human/MTHFD1/MTHFD1-ai-review.yaml	MTHFD1	P11586	NCBITaxon:9606	Homo sapiens	53	R-HSA-200711	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG	yes	reactome/R-HSA-200711.md	MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization for the synthetase reaction; correct core location.
human	MTHFD1	genes/human/MTHFD1/MTHFD1-ai-review.yaml	MTHFD1	P11586	NCBITaxon:9606	Homo sapiens	54	R-HSA-200718	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG	yes	reactome/R-HSA-200718.md	MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization for the dehydrogenase reaction; correct core location.
human	MTHFD1	genes/human/MTHFD1/MTHFD1-ai-review.yaml	MTHFD1	P11586	NCBITaxon:9606	Homo sapiens	55	R-HSA-200740	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate	yes	reactome/R-HSA-200740.md	5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization for the cyclohydrolase reaction; correct core location.
human	MTHFD1L	genes/human/MTHFD1L/MTHFD1L-ai-review.yaml	MTHFD1L	Q6UB35	NCBITaxon:9606	Homo sapiens	21	R-HSA-5696839	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF	yes	reactome/R-HSA-5696839.md	MTHFD1L dimer ligates HCOOH to THF to form 10-formyl-THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the MTHFD1L ligation reaction (formate + THF -> 10-formyl-THF) in the mitochondrial matrix, the correct compartment for this soluble enzyme.
human	MTHFD1L	genes/human/MTHFD1L/MTHFD1L-ai-review.yaml	MTHFD1L	Q6UB35	NCBITaxon:9606	Homo sapiens	22	R-HSA-6801456	MTHFD1L transforms 10-formyl-THF to HCOOH and THF	yes	reactome/R-HSA-6801456.md	MTHFD1L transforms 10-formyl-THF to HCOOH and THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome places the reverse MTHFD1L reaction (10-formyl-THF -> formate + THF), which releases formate for export, in the mitochondrial matrix.
human	MTHFD2	genes/human/MTHFD2/MTHFD2-ai-review.yaml	MTHFD2	P13995	NCBITaxon:9606	Homo sapiens	14	R-HSA-196757	Metabolism of folate and pterines	yes	reactome/R-HSA-196757.md	Metabolism of folate and pterines	Homo sapiens	GO:0046655	folic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway-level assignment (Metabolism of folate and pterines). Correct but general; the specific tetrahydrofolate interconversion / metabolic-process terms are preferred as core. Retained as non-core.
human	MTHFD2	genes/human/MTHFD2/MTHFD2-ai-review.yaml	MTHFD2	P13995	NCBITaxon:9606	Homo sapiens	15	R-HSA-6801328	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF	yes	reactome/R-HSA-6801328.md	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF	Homo sapiens	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	TAS	enables	MF	false		ACCEPT	Core cyclohydrolase activity, curated by Reactome as the reaction converting 5,10-methenyl-THF to 10-formyl-THF. Accept.
human	MTHFD2	genes/human/MTHFD2/MTHFD2-ai-review.yaml	MTHFD2	P13995	NCBITaxon:9606	Homo sapiens	16	R-HSA-6801462	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF	yes	reactome/R-HSA-6801462.md	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF	Homo sapiens	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	TAS	enables	MF	false		ACCEPT	Core NAD-dependent dehydrogenase activity, curated by Reactome as the oxidation of 5,10-methylene-THF to 5,10-methenyl-THF. Accept.
human	MTHFD2	genes/human/MTHFD2/MTHFD2-ai-review.yaml	MTHFD2	P13995	NCBITaxon:9606	Homo sapiens	24	R-HSA-6801328	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF	yes	reactome/R-HSA-6801328.md	MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct specific matrix localization, curated by Reactome. Accept.
human	MTHFD2	genes/human/MTHFD2/MTHFD2-ai-review.yaml	MTHFD2	P13995	NCBITaxon:9606	Homo sapiens	25	R-HSA-6801462	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF	yes	reactome/R-HSA-6801462.md	MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct specific matrix localization, curated by Reactome (duplicate of the R-HSA-6801328 assignment). Accept.
human	MTHFR	genes/human/MTHFR/MTHFR-ai-review.yaml	MTHFR	P42898	NCBITaxon:9606	Homo sapiens	40	R-HSA-200676	MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the MTHFR-catalysed reduction of 5,10-methylene-THF-PG to 5-methyl-THF-PG in the cytosol.
human	MTMR9	genes/human/MTMR9/MTMR9-ai-review.yaml	MTMR9	Q96QG7	NCBITaxon:9606	Homo sapiens	57	R-HSA-6809254	MTMR8 binds MTMR9	yes	reactome/R-HSA-6809254.md	MTMR8 binds MTMR9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
human	MTMR9	genes/human/MTMR9/MTMR9-ai-review.yaml	MTMR9	Q96QG7	NCBITaxon:9606	Homo sapiens	58	R-HSA-6809309	MTMR6 binds MTMR9	yes	reactome/R-HSA-6809309.md	MTMR6 binds MTMR9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
human	MTMR9	genes/human/MTMR9/MTMR9-ai-review.yaml	MTMR9	Q96QG7	NCBITaxon:9606	Homo sapiens	59	R-HSA-6809320	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane	yes	reactome/R-HSA-6809320.md	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
human	MTMR9	genes/human/MTMR9/MTMR9-ai-review.yaml	MTMR9	Q96QG7	NCBITaxon:9606	Homo sapiens	60	R-HSA-6809325	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane	yes	reactome/R-HSA-6809325.md	PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol: MTMR9 is an intracellular regulator that associates with myotubularin phosphatases; cytoplasmic localization is consistent with direct localization and complex experiments.
human	MTMR9	genes/human/MTMR9/MTMR9-ai-review.yaml	MTMR9	Q96QG7	NCBITaxon:9606	Homo sapiens	61	R-HSA-1660499	Synthesis of PIPs at the plasma membrane	yes	reactome/R-HSA-1660499.md	Synthesis of PIPs at the plasma membrane	Homo sapiens	GO:0006661	phosphatidylinositol biosynthetic process	TAS	involved_in	BP	false		UNDECIDED	phosphatidylinositol biosynthetic process: MTMR complexes interconvert phosphoinositides through dephosphorylation. The specific Reactome phosphatidylinositol biosynthesis placement should be traced to its reaction rather than inferred from generic phosphoinositide involvement.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	18	R-HSA-1614635	Sulfur amino acid metabolism	yes	reactome/R-HSA-1614635.md	Sulfur amino acid metabolism	Homo sapiens	GO:0000096	sulfur amino acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Homocysteine and methionine are sulfur amino acids, and the MTR reaction is part of sulfur amino acid metabolism. This Reactome TAS is correct but is a broad parent process.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	19	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS placing MTR in cobalamin (Cbl) metabolism, consistent with its cobalamin-dependent mechanism and role in the cytosolic Cbl-processing complex.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	20	R-HSA-156581	Methylation	yes	reactome/R-HSA-156581.md	Methylation	Homo sapiens	GO:0032259	methylation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	MTR is a methyltransferase (transfers a methyl group from methylcobalamin/ 5-methyltetrahydrofolate to homocysteine), so participation in methylation is correct but is a very broad process term.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	21	R-HSA-174374	MTR transfers CH3 from MeCbl to HCYS	no				GO:0008705	methionine synthase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for methionine synthase activity, describing the half reaction in which the methyl group of methylcobalamin is transferred to homocysteine. Core molecular function.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	22	R-HSA-3149539	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin	no				GO:0008705	methionine synthase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for methionine synthase activity, describing the half reaction in which cob(I)alamin is re-methylated by 5-methyltetrahydrofolate. Core molecular function.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	32	R-HSA-3321918	Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (in the context of a defective-MTR reaction). Consistent with the established cytosolic localization.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	33	R-HSA-3322140	Defective MTR does not transfer CH3 group from MeCbl to HCYS	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (defective-MTR reaction context). Consistent with the established cytosolic localization.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	35	R-HSA-174374	MTR transfers CH3 from MeCbl to HCYS	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (methyl-transfer half reaction). Consistent with established cytosolic localization.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	36	R-HSA-3149518	MTRR reduces cob(II)alamin to meCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (MTRR reductive-reactivation reaction context). Consistent with established cytosolic localization.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	37	R-HSA-3149539	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (cob(I)alamin re-methylation half reaction). Consistent with established cytosolic localization.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	38	R-HSA-3204318	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	yes	reactome/R-HSA-3204318.md	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (cobalamin transfer from MMACHC:MMADHC complex to MTRR:MTR). Consistent with established cytosolic localization and the cytosolic Cbl-processing complex.
human	MTR	genes/human/MTR/MTR-ai-review.yaml	MTR	Q99707	NCBITaxon:9606	Homo sapiens	39	R-HSA-3318563	Defective MTRR does not convert cob(II)alamin to MeCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing MTR to the cytosol (defective-MTRR reaction context). Consistent with established cytosolic localization.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	15	R-HSA-9759218	Cobalamin (Cbl) metabolism	yes	reactome/R-HSA-9759218.md	Cobalamin (Cbl) metabolism	Homo sapiens	GO:0009235	cobalamin metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation to cobalamin metabolism (Cobalamin (Cbl) metabolism pathway). MTRR reduces the cobalamin cofactor and participates in the cytosolic cobalamin processing complex.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	19	R-HSA-174374	MTR transfers CH3 from MeCbl to HCYS	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (reaction: MTR transfers CH3 from MeCbl to HCYS). Correct compartment for the methionine synthase reaction that MTRR serves.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	20	R-HSA-3149518	MTRR reduces cob(II)alamin to meCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (reaction: MTRR reduces cob(II)alamin to meCbl), the reaction directly catalysed by MTRR, in the cytosol.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	21	R-HSA-3149539	MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (reaction: MTR transfers CH3 from 5-methyl-THF to cob(I)alamin). Correct cytosolic compartment.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	22	R-HSA-3204318	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	yes	reactome/R-HSA-3204318.md	cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (reaction: cob(II)alamin transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR), reflecting the cytosolic cobalamin handoff complex.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	23	R-HSA-3318563	Defective MTRR does not convert cob(II)alamin to MeCbl	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (disease reaction: Defective MTRR does not convert cob(II)alamin to MeCbl). Correct cytosolic compartment.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	24	R-HSA-3321918	Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (disease reaction: Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin). Correct cytosolic compartment.
human	MTRR	genes/human/MTRR/MTRR-ai-review.yaml	MTRR	Q9UBK8	NCBITaxon:9606	Homo sapiens	25	R-HSA-3322140	Defective MTR does not transfer CH3 group from MeCbl to HCYS	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localisation (disease reaction: Defective MTR does not transfer CH3 group from MeCbl to HCYS). Correct cytosolic compartment.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	19	R-HSA-6790022	Expression of STAT3-upregulated plasma membrane proteins	yes	reactome/R-HSA-6790022.md	Expression of STAT3-upregulated plasma membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway annotation for ""Expression of STAT3-upregulated plasma membrane proteins"" includes MUC1 as a STAT3-regulated plasma membrane protein. This supports plasma membrane localization but in a specific regulatory context."
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	20	R-HSA-8858500	CLEC10A binds Tn-MUC1	yes	reactome/R-HSA-8858500.md	CLEC10A binds Tn-MUC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway annotation for ""CLEC10A binds Tn-MUC1"" describes interaction between C-type lectin receptor CLEC10A and tumor-associated Tn antigen on MUC1 at the plasma membrane. This represents recognition of aberrantly glycosylated MUC1."
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	21	R-HSA-6786012	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins	yes	reactome/R-HSA-6786012.md	CHST4 transfers SO4(2-) from PAPS to Core 2 mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway ""CHST4 transfers SO4(2-) from PAPS to Core 2 mucins"" describes sulfation of MUC1 in the Golgi lumen. MUC1 transits through the Golgi during biosynthesis where it undergoes extensive O-glycosylation and other modifications."
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	22	R-HSA-5694487	A4GNT transfers GlcNAc to core 2 mucins	yes	reactome/R-HSA-5694487.md	A4GNT transfers GlcNAc to core 2 mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome pathway ""A4GNT transfers GlcNAc to core 2 mucins"" describes glycosylation of MUC1 in the Golgi. Multiple Reactome glycosylation pathways annotate MUC1 to Golgi lumen as the site where O-glycan modifications occur."
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	31	R-HSA-1964505	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	yes	reactome/R-HSA-1964505.md	C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	32	R-HSA-5096532	Defective GALNT12 does not transfer GalNAc to mucins	yes	reactome/R-HSA-5096532.md	Defective GALNT12 does not transfer GalNAc to mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	33	R-HSA-5096537	Defective GALNT3 does not transfer GalNAc to mucins	yes	reactome/R-HSA-5096537.md	Defective GALNT3 does not transfer GalNAc to mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	34	R-HSA-6785524	Defective C1GALT1C1 does not bind C1GALT1	yes	reactome/R-HSA-6785524.md	Defective C1GALT1C1 does not bind C1GALT1	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	35	R-HSA-913675	GALNTs transfer GalNAc to Mucins to form Tn antigens	yes	reactome/R-HSA-913675.md	GALNTs transfer GalNAc to Mucins to form Tn antigens	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	36	R-HSA-914005	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein	yes	reactome/R-HSA-914005.md	Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	37	R-HSA-914006	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein	yes	reactome/R-HSA-914006.md	Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	38	R-HSA-914008	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein	yes	reactome/R-HSA-914008.md	Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	39	R-HSA-914010	B3GNT6 transfers GlcNAc to Tn antigen	yes	reactome/R-HSA-914010.md	B3GNT6 transfers GlcNAc to Tn antigen	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	40	R-HSA-914017	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein	yes	reactome/R-HSA-914017.md	Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	41	R-HSA-977071	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	yes	reactome/R-HSA-977071.md	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	42	R-HSA-1964501	Addition of galactose to Core 6 glycoprotein	yes	reactome/R-HSA-1964501.md	Addition of galactose to Core 6 glycoprotein	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	43	R-HSA-914012	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins	yes	reactome/R-HSA-914012.md	GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	44	R-HSA-914018	GCNT3 transfers GlcNAc to Core 3 mucin	yes	reactome/R-HSA-914018.md	GCNT3 transfers GlcNAc to Core 3 mucin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	45	R-HSA-981497	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position	yes	reactome/R-HSA-981497.md	ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	46	R-HSA-981809	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen	yes	reactome/R-HSA-981809.md	ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MUC1	genes/human/MUC1/MUC1-ai-review.yaml	MUC1	P15941	NCBITaxon:9606	Homo sapiens	47	R-HSA-981814	ST6GALNAC2 transfers sialic acid to Core 1 mucins	yes	reactome/R-HSA-981814.md	ST6GALNAC2 transfers sialic acid to Core 1 mucins	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome O-glycosylation pathway annotation. MUC1 transits through the Golgi lumen during biosynthesis where it undergoes extensive O-glycosylation by various glycosyltransferases.
human	MVB12A	genes/human/MVB12A/MVB12A-ai-review.yaml	MVB12A	Q96EY5	NCBITaxon:9606	Homo sapiens	25	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12A/ESCRT-I function.
human	MVB12A	genes/human/MVB12A/MVB12A-ai-review.yaml	MVB12A	Q96EY5	NCBITaxon:9606	Homo sapiens	26	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12A/ESCRT-I function.
human	MVB12A	genes/human/MVB12A/MVB12A-ai-review.yaml	MVB12A	Q96EY5	NCBITaxon:9606	Homo sapiens	27	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12A/ESCRT-I function.
human	MVB12A	genes/human/MVB12A/MVB12A-ai-review.yaml	MVB12A	Q96EY5	NCBITaxon:9606	Homo sapiens	28	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12A/ESCRT-I function.
human	MVB12A	genes/human/MVB12A/MVB12A-ai-review.yaml	MVB12A	Q96EY5	NCBITaxon:9606	Homo sapiens	29	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12A/ESCRT-I function.
human	MVB12B	genes/human/MVB12B/MVB12B-ai-review.yaml	MVB12B	Q9H7P6	NCBITaxon:9606	Homo sapiens	13	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12B/ESCRT-I function.
human	MVB12B	genes/human/MVB12B/MVB12B-ai-review.yaml	MVB12B	Q9H7P6	NCBITaxon:9606	Homo sapiens	14	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12B/ESCRT-I function.
human	MVB12B	genes/human/MVB12B/MVB12B-ai-review.yaml	MVB12B	Q9H7P6	NCBITaxon:9606	Homo sapiens	15	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12B/ESCRT-I function.
human	MVB12B	genes/human/MVB12B/MVB12B-ai-review.yaml	MVB12B	Q9H7P6	NCBITaxon:9606	Homo sapiens	16	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12B/ESCRT-I function.
human	MVB12B	genes/human/MVB12B/MVB12B-ai-review.yaml	MVB12B	Q9H7P6	NCBITaxon:9606	Homo sapiens	17	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to MVB12B/ESCRT-I function.
human	MVD	genes/human/MVD/MVD-ai-review.yaml	MVD	P53602	NCBITaxon:9606	Homo sapiens	15	R-HSA-1655836	Expression of Diphosphomevalonate Decarboxylase (MVD)	yes	reactome/R-HSA-1655836.md	Expression of Diphosphomevalonate Decarboxylase (MVD)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing MVD in the cytosol.
human	MVD	genes/human/MVD/MVD-ai-review.yaml	MVD	P53602	NCBITaxon:9606	Homo sapiens	16	R-HSA-191414	MVD decarboxylates MVA5PP to IPPP	yes	reactome/R-HSA-191414.md	MVD decarboxylates MVA5PP to IPPP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (MVD decarboxylates MVA5PP to IPPP reaction) placing MVD in the cytosol.
human	MVK	genes/human/MVK/MVK-ai-review.yaml	MVK	Q03426	NCBITaxon:9606	Homo sapiens	28	R-HSA-1655846	Expression of Mevalonate Kinase (MVK)	yes	reactome/R-HSA-1655846.md	Expression of Mevalonate Kinase (MVK)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curator assertion of cytosolic localization.
human	MVK	genes/human/MVK/MVK-ai-review.yaml	MVK	Q03426	NCBITaxon:9606	Homo sapiens	29	R-HSA-191380	Mevalonate is phosphorylated to mevalonate-5-phosphate	yes	reactome/R-HSA-191380.md	Mevalonate is phosphorylated to mevalonate-5-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curator assertion of cytosolic localization for the mevalonate-to-mevalonate-5-phosphate reaction.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	177	R-HSA-5696914	USP28 deubiquitinates CLSPN and MYC	yes	reactome/R-HSA-5696914.md	USP28 deubiquitinates CLSPN and MYC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	179	R-HSA-1484099	MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex	yes	reactome/R-HSA-1484099.md	MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	180	R-HSA-1980067	NOTCH1 stimulates MYC transcription	yes	reactome/R-HSA-1980067.md	NOTCH1 stimulates MYC transcription	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	181	R-HSA-2220985	NOTCH1 PEST domain mutants stimulate MYC transcription	yes	reactome/R-HSA-2220985.md	NOTCH1 PEST domain mutants stimulate MYC transcription	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	182	R-HSA-4411357	TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene	yes	reactome/R-HSA-4411357.md	TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	183	R-HSA-5687083	MYC binds MAPKAPK5 gene	yes	reactome/R-HSA-5687083.md	MYC binds MAPKAPK5 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	184	R-HSA-5687113	MYC mRNA translation is negatively regulated by miR-34B and C	yes	reactome/R-HSA-5687113.md	MYC mRNA translation is negatively regulated by miR-34B and C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	185	R-HSA-6790036	Expression of STAT3-upregulated nuclear proteins	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	186	R-HSA-8865265	TFAP2C homodimer binds MYC and KDM5B	yes	reactome/R-HSA-8865265.md	TFAP2C homodimer binds MYC and KDM5B	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	187	R-HSA-8865280	TFAP2C homodimer binds the CDKN1A (p21) gene promoter	yes	reactome/R-HSA-8865280.md	TFAP2C homodimer binds the CDKN1A (p21) gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	188	R-HSA-8932400	MYC:MAX binds the CDC25A gene	yes	reactome/R-HSA-8932400.md	MYC:MAX binds the CDC25A gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	189	R-HSA-9011975	Estrogen-responsive MYC gene expression	yes	reactome/R-HSA-9011975.md	Estrogen-responsive MYC gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	190	R-HSA-9725332	MYC/MYCN bind the ALK gene	yes	reactome/R-HSA-9725332.md	MYC/MYCN bind the ALK gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	191	R-HSA-9762097	MYC binds the NFE2L2 promoter	yes	reactome/R-HSA-9762097.md	MYC binds the NFE2L2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYC	genes/human/MYC/MYC-ai-review.yaml	MYC	P01106	NCBITaxon:9606	Homo sapiens	192	R-HSA-9816153	MYC,MYCN bind MIR9-3 gene locus	yes	reactome/R-HSA-9816153.md	MYC,MYCN bind MIR9-3 gene locus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	MYC nucleoplasm localization from Reactome pathway.
human	MYH10	genes/human/MYH10/MYH10-ai-review.yaml	MYH10	P35580	NCBITaxon:9606	Homo sapiens	23	R-HSA-5668932	PAK2 phosphorylates myosin regulatory light chain (MRLC)	yes	reactome/R-HSA-5668932.md	PAK2 phosphorylates myosin regulatory light chain (MRLC)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, from the Reactome non-muscle myosin II complex in the PAK2-MRLC phosphorylation reaction.
human	MYH9	genes/human/MYH9/MYH9-ai-review.yaml	MYH9	P35579	NCBITaxon:9606	Homo sapiens	77	R-HSA-5668932	PAK2 phosphorylates myosin regulatory light chain (MRLC)	yes	reactome/R-HSA-5668932.md	PAK2 phosphorylates myosin regulatory light chain (MRLC)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS).
human	MYH9	genes/human/MYH9/MYH9-ai-review.yaml	MYH9	P35579	NCBITaxon:9606	Homo sapiens	78	R-HSA-9663426	sCD163 binds MYH9 in T-cells	yes	reactome/R-HSA-9663426.md	sCD163 binds MYH9 in T-cells	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS).
human	MYH9	genes/human/MYH9/MYH9-ai-review.yaml	MYH9	P35579	NCBITaxon:9606	Homo sapiens	79	R-HSA-9724090	MYH9- and RNF213-ALK fusions are phosphorylated	yes	reactome/R-HSA-9724090.md	MYH9- and RNF213-ALK fusions are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (Reactome TAS).
human	MYL10	genes/human/MYL10/MYL10-ai-review.yaml	MYL10	Q9BUA6	NCBITaxon:9606	Homo sapiens	8	R-HSA-445699	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-445699.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic association is compatible with a soluble regulatory light-chain protein.
human	MYL10	genes/human/MYL10/MYL10-ai-review.yaml	MYL10	Q9BUA6	NCBITaxon:9606	Homo sapiens	9	R-HSA-445700	Myosin Binds ATP	yes	reactome/R-HSA-445700.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic association is compatible with a soluble regulatory light-chain protein.
human	MYL10	genes/human/MYL10/MYL10-ai-review.yaml	MYL10	Q9BUA6	NCBITaxon:9606	Homo sapiens	10	R-HSA-445704	Calcium Binds Caldesmon	yes	reactome/R-HSA-445704.md	Calcium Binds Caldesmon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic association is compatible with a soluble regulatory light-chain protein.
human	MYL10	genes/human/MYL10/MYL10-ai-review.yaml	MYL10	Q9BUA6	NCBITaxon:9606	Homo sapiens	11	R-HSA-445705	Release Of ADP From Myosin	yes	reactome/R-HSA-445705.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic association is compatible with a soluble regulatory light-chain protein.
human	MYL10	genes/human/MYL10/MYL10-ai-review.yaml	MYL10	Q9BUA6	NCBITaxon:9606	Homo sapiens	12	R-HSA-445813	Phosphorylation of Smooth Muscle Myosin Light Chains	yes	reactome/R-HSA-445813.md	Phosphorylation of Smooth Muscle Myosin Light Chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic association is compatible with a soluble regulatory light-chain protein.
human	NADK	genes/human/NADK/NADK-ai-review.yaml	NADK	O95544	NCBITaxon:9606	Homo sapiens	17	R-HSA-197198	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+	yes	reactome/R-HSA-197198.md	NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic localization from the Reactome NADP-synthesis reaction, which explicitly describes NADK as the ""Cytosolic NAD+ kinase"". Correct core localization."
human	NADK2	genes/human/NADK2/NADK2-ai-review.yaml	NADK2	Q4G0N4	NCBITaxon:9606	Homo sapiens	10	R-HSA-8955030	NADK2 dimer phosphorylates NAD+ to NADP+	yes	reactome/R-HSA-8955030.md	NADK2 dimer phosphorylates NAD+ to NADP+	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial matrix, from the reaction ""NADK2 dimer phosphorylates NAD+ to NADP+"". This is the correct compartment for the NADK2 catalytic activity and is the core localization."
human	NADK2	genes/human/NADK2/NADK2-ai-review.yaml	NADK2	Q4G0N4	NCBITaxon:9606	Homo sapiens	11	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS matrix localization derived from an event in which NADK2 is a substrate of the LONP1 matrix protease (""LONP1 degrades mitochondrial matrix proteins""). The compartment (matrix) is correct, but this event describes LONP1's function, not NADK2's, so it is a non-core, indirect localization annotation."
human	NADK2	genes/human/NADK2/NADK2-ai-review.yaml	NADK2	Q4G0N4	NCBITaxon:9606	Homo sapiens	12	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS matrix localization from an event in which NADK2 is bound as a substrate by the LONP1 matrix protease (""LONP1 binds mitochondrial matrix proteins""). Correct compartment but an indirect, non-core localization annotation."
human	NADSYN1	genes/human/NADSYN1/NADSYN1-ai-review.yaml	NADSYN1	Q6IA69	NCBITaxon:9606	Homo sapiens	17	R-HSA-197271	NADSYN1 hexamer amidates NAAD to NAD+	yes	reactome/R-HSA-197271.md	NADSYN1 hexamer amidates NAAD to NAD+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) that NADSYN1 acts as a cytosolic hexamer catalyzing the final NAD+ step. This is the correct, specific subcellular localization of the enzyme.
human	NAGK	genes/human/NAGK/NAGK-ai-review.yaml	NAGK	Q9UJ70	NCBITaxon:9606	Homo sapiens	21	R-HSA-6803771	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P	yes	reactome/R-HSA-6803771.md	NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NAGK is a soluble cytosolic enzyme (Reactome, consistent with its role in cytosolic amino-sugar salvage and with cytosolic activity in the Neu5Gc study). Correct core localization.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	8	R-HSA-2024096	HS-GAG degradation	yes	reactome/R-HSA-2024096.md	HS-GAG degradation	Homo sapiens	GO:0030200	heparan sulfate proteoglycan catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation placing NAGLU in the lysosomal degradation of heparan sulfate glycosaminoglycan (HS-GAG degradation pathway).
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	9	R-HSA-1678742	NAGLU hydrolyses Heparan sulfate chain(4)	yes	reactome/R-HSA-1678742.md	NAGLU hydrolyses Heparan sulfate chain(4)	Homo sapiens	GO:0004561	alpha-N-acetylglucosaminidase activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) annotation of the core catalytic activity in the reaction ""NAGLU hydrolyses Heparan sulfate chain(4)""."
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	10	R-HSA-2090038	NAGLU hydrolyses heparan chain(2)	yes	reactome/R-HSA-2090038.md	NAGLU hydrolyses heparan chain(2)	Homo sapiens	GO:0004561	alpha-N-acetylglucosaminidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core catalytic activity in a second heparan chain hydrolysis reaction.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	11	R-HSA-2263496	Defective NAGLU does not hydrolyse Heparan sulfate chain(4)	yes	reactome/R-HSA-2263496.md	Defective NAGLU does not hydrolyse Heparan sulfate chain(4)	Homo sapiens	GO:0004561	alpha-N-acetylglucosaminidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core catalytic activity, from a reaction contrasting wild-type with defective NAGLU.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	12	R-HSA-9036052	Defective NAGLU does not hydrolyse heparan chain(2)	yes	reactome/R-HSA-9036052.md	Defective NAGLU does not hydrolyse heparan chain(2)	Homo sapiens	GO:0004561	alpha-N-acetylglucosaminidase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core catalytic activity, from a further heparan chain hydrolysis reaction.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	13	R-HSA-2263496	Defective NAGLU does not hydrolyse Heparan sulfate chain(4)	yes	reactome/R-HSA-2263496.md	Defective NAGLU does not hydrolyse Heparan sulfate chain(4)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) location annotation placing NAGLU in the lysosomal lumen, where it acts on soluble heparan sulfate fragments.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	14	R-HSA-9036052	Defective NAGLU does not hydrolyse heparan chain(2)	yes	reactome/R-HSA-9036052.md	Defective NAGLU does not hydrolyse heparan chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) location annotation to lysosomal lumen, from a second reaction.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	18	R-HSA-1678742	NAGLU hydrolyses Heparan sulfate chain(4)	yes	reactome/R-HSA-1678742.md	NAGLU hydrolyses Heparan sulfate chain(4)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) location annotation to lysosomal lumen, from the primary NAGLU heparan sulfate hydrolysis reaction.
human	NAGLU	genes/human/NAGLU/NAGLU-ai-review.yaml	NAGLU	P54802	NCBITaxon:9606	Homo sapiens	19	R-HSA-2090038	NAGLU hydrolyses heparan chain(2)	yes	reactome/R-HSA-2090038.md	NAGLU hydrolyses heparan chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) location annotation to lysosomal lumen, from a second heparan hydrolysis reaction.
human	NAGS	genes/human/NAGS/NAGS-ai-review.yaml	NAGS	Q8N159	NCBITaxon:9606	Homo sapiens	12	R-HSA-9955697	NAGS variants don't synthesize N-acetylglutamate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome) placing NAGS in the mitochondrial matrix, consistent with all other localization evidence.
human	NAGS	genes/human/NAGS/NAGS-ai-review.yaml	NAGS	Q8N159	NCBITaxon:9606	Homo sapiens	18	R-HSA-70542	glutamate + acetyl CoA => N-acetyl glutamate + CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"TAS annotation (Reactome) for the reaction ""glutamate + acetyl CoA => N-acetyl glutamate + CoA"" localizing NAGS to the mitochondrial matrix. Consistent with all other localization evidence."
human	NAMPT	genes/human/NAMPT/NAMPT-ai-review.yaml	NAMPT	P43490	NCBITaxon:9606	Homo sapiens	15	R-HSA-196807	Nicotinate metabolism	yes	reactome/R-HSA-196807.md	Nicotinate metabolism	Homo sapiens	GO:1901847	nicotinate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"TAS annotation from the Reactome ""Nicotinate metabolism"" grouping. NAMPT's substrate is nicotinamide (an amide), not nicotinate; the more precise process is NAD+ salvage/biosynthesis. Retained as a broad grouping term but non-core."
human	NAMPT	genes/human/NAMPT/NAMPT-ai-review.yaml	NAMPT	P43490	NCBITaxon:9606	Homo sapiens	16	R-HSA-197250	NAMPT transfers PRIB to NAM to form NAMN	yes	reactome/R-HSA-197250.md	NAMPT transfers PRIB to NAM to form NAMN	Homo sapiens	GO:0047280	nicotinamide phosphoribosyltransferase activity	TAS	enables	MF	false		ACCEPT	"TAS annotation from the Reactome reaction ""NAMPT transfers PRIB to NAM to form NAMN"" to the core catalytic MF. Correct; corroborates the experimental and IBA annotations. Core function."
human	NAMPT	genes/human/NAMPT/NAMPT-ai-review.yaml	NAMPT	P43490	NCBITaxon:9606	Homo sapiens	29	R-HSA-197250	NAMPT transfers PRIB to NAM to form NAMN	yes	reactome/R-HSA-197250.md	NAMPT transfers PRIB to NAM to form NAMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation (Reactome) to cytosol, the compartment where NAMPT performs the rate-limiting NAD+ salvage step. This is the core catalytic localization of iNAMPT.
human	NANP	genes/human/NANP/NANP-ai-review.yaml	NANP	Q8TBE9	NCBITaxon:9606	Homo sapiens	9	R-HSA-4084989	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac	yes	reactome/R-HSA-4084989.md	NANP dephosphorylates Neu5Ac-9-P to Neu5Ac	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome (TAS). Consistent with NANP being a soluble HAD-superfamily phosphatase with no transmembrane segment or signal peptide, acting on cytosolic sialic-acid pathway intermediates. Accept as the core cellular location.
human	NANS	genes/human/NANS/NANS-ai-review.yaml	NANS	Q9NR45	NCBITaxon:9606	Homo sapiens	6	R-HSA-4084976	NANS converts ManNAc-6-P to Neu5Ac-9-P	yes	reactome/R-HSA-4084976.md	NANS converts ManNAc-6-P to Neu5Ac-9-P	Homo sapiens	GO:0047444	N-acylneuraminate-9-phosphate synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation for the NANS reaction (ManNAc-6-P -> Neu5Ac-9-P). Correct core molecular function.
human	NANS	genes/human/NANS/NANS-ai-review.yaml	NANS	Q9NR45	NCBITaxon:9606	Homo sapiens	13	R-HSA-4084976	NANS converts ManNAc-6-P to Neu5Ac-9-P	yes	reactome/R-HSA-4084976.md	NANS converts ManNAc-6-P to Neu5Ac-9-P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct cytosolic localization for this soluble sialic-acid-synthesis enzyme (Reactome traceable annotation). Accept.
human	NAPRT	genes/human/NAPRT/NAPRT-ai-review.yaml	NAPRT	Q6XQN6	NCBITaxon:9606	Homo sapiens	12	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome-derived localization from the neutrophil ""Exocytosis of azurophil granule lumen proteins"" pathway. NAPRT was detected in neutrophil granule/secretory proteomics and modeled as released extracellularly, but it is a soluble cytosolic enzyme; the extracellular location is secondary and not where its NAD-synthesis function occurs. Keep as a non-core localization."
human	NAPRT	genes/human/NAPRT/NAPRT-ai-review.yaml	NAPRT	Q6XQN6	NCBITaxon:9606	Homo sapiens	13	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (neutrophil degranulation) localization to the azurophil granule lumen, based on detection of NAPRT in neutrophil granule proteomics. This is a secondary/incidental localization rather than the cytosolic site of catalysis. Keep as non-core.
human	NAPRT	genes/human/NAPRT/NAPRT-ai-review.yaml	NAPRT	Q6XQN6	NCBITaxon:9606	Homo sapiens	16	R-HSA-197186	NAPRT1 dimer transfers PRIB to NCA to form NAMN	yes	reactome/R-HSA-197186.md	NAPRT1 dimer transfers PRIB to NCA to form NAMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome (R-HSA-197186, ""NAPRT1 dimer transfers PRIB to NCA to form NAMN"") places the catalytic reaction in the cytosol. Consistent with the experimental IDA localization. Accept as core location."
human	NAT10	genes/human/NAT10/NAT10-ai-review.yaml	NAT10	Q9H0A0	NCBITaxon:9606	Homo sapiens	36	R-HSA-6790901	rRNA modification in the nucleus and cytosol	yes	reactome/R-HSA-6790901.md	rRNA modification in the nucleus and cytosol	Homo sapiens	GO:0000154	rRNA modification	TAS	involved_in	BP	false		ACCEPT	Reactome pathway assertion of rRNA modification.
human	NAT10	genes/human/NAT10/NAT10-ai-review.yaml	NAT10	Q9H0A0	NCBITaxon:9606	Homo sapiens	50	R-HSA-6790987	NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842	yes	reactome/R-HSA-6790987.md	NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Generic nuclear compartment assignment from a Reactome reaction.
human	NBR1	genes/human/NBR1/NBR1-ai-review.yaml	NBR1	Q14596	NCBITaxon:9606	Homo sapiens	36	R-HSA-9664867	NBR1 binds MAP1LC3B	yes	reactome/R-HSA-9664867.md	NBR1 binds MAP1LC3B	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pexophagy curation (NBR1 binds MAP1LC3B) placing NBR1 at the peroxisomal membrane during peroxisome turnover.
human	NBR1	genes/human/NBR1/NBR1-ai-review.yaml	NBR1	Q14596	NCBITaxon:9606	Homo sapiens	37	R-HSA-9664880	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	yes	reactome/R-HSA-9664880.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pexophagy curation (MAP1LC3B binds ATM:Ub-p-PEX5:SQSTM1:NBR1).
human	NBR1	genes/human/NBR1/NBR1-ai-review.yaml	NBR1	Q14596	NCBITaxon:9606	Homo sapiens	38	R-HSA-9664881	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664881.md	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pexophagy curation (NBR1 binds ATM:Ub-p-PEX5:SQSTM1).
human	NCOA4	genes/human/NCOA4/NCOA4-ai-review.yaml	NCOA4	Q13772	NCBITaxon:9606	Homo sapiens	18	R-HSA-9843120	Coactivators are recruited to liganded PPARG:RXRA heterodimer	yes	reactome/R-HSA-9843120.md	Coactivators are recruited to liganded PPARG:RXRA heterodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS annotation from Reactome pathway ""Coactivators are recruited to liganded PPARG:RXRA heterodimer"". NCOA4 can coactivate PPAR-gamma (PMID:10347167)."
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	66	R-HSA-9010096	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	yes	reactome/R-HSA-9010096.md	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Nicastrin is present in endosomal membranes where the gamma-secretase complex cleaves internalized substrates such as APP-CTFs.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	75	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nicastrin is annotated to the azurophil (neutrophil) granule membrane via neutrophil-degranulation pathways; a tissue-specific localization, not the core complex function.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	81	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	82	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	83	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	84	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	85	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	86	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	87	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	88	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	89	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	90	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NCSTN	genes/human/NCSTN/NCSTN-ai-review.yaml	NCSTN	Q92542	NCBITaxon:9606	Homo sapiens	91	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	A pool of mature gamma-secretase, including nicastrin, resides at the plasma membrane where it cleaves cell-surface substrate C-terminal fragments such as Notch NEXT.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	24	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Mad1 binds kinetochore', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	25	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'MAD2 converted to an inhibitory state', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	26	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'MAD2 associates with the Mad1 kinetochore complex', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	27	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Release of activated MAD2 from kinetochores', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	28	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Phosphorylation of cohesin by PLK1 at centromeres', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	29	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'PP2A-B56 dephosphorylates centromeric cohesin', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	30	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'ESPL1 cleaves centromeric cohesin', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	31	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Separation of sister chromatids', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	32	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'CDK1 phosphorylates CDCA5 at centromeres', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	33	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Kinetochore assembly', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	34	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'AJUBA facilitates AURKA autophosphorylation', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	35	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'AJUBA binds centrosome-associated AURKA', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	36	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'AURKA phosphorylates PLK1', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	37	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'BORA binds PLK1 and AURKA', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	38	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Kinetochore capture of astral microtubules', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	39	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Plk1-mediated phosphorylation of Nlp', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	40	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Recruitment of additional gamma tubulin/gamma TuRC to the centrosome', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	41	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Loss of C-Nap-1 from centrosomes', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	42	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Dissociation of Phospho-Nlp from the centrosome', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	43	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Recruitment of Plk1 to centrosomes', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	44	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Association of NuMA with microtubules', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	45	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Recruitment of CDK11p58 to the centrosomes', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	46	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Translocation of NuMA to the centrosomes', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	47	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'RAB3IP stimulates nucleotide exchange on RAB8A', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	48	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'C2CD3 binds the mother centriole', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	49	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'C2CD3 and OFD1 recruit distal appendage proteins to the centriole', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	50	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'CP110 and CEP97 dissociate from the centriole', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	51	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'The distal appendage proteins recruit TTBK2', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	52	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Recruitment of transition zone proteins', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	53	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'MARK4 binds ODF2 in the centriole', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	54	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	55	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'CDC42:GTP recruits DIAPH2-2 to kinetochores', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	56	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'AURKB phosphorylates DIAPH2-2 at kinetochores', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	57	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'Kinetochore capture of astral microtubules regulated by CDC42/DIAPH2', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	58	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'TPX2 binds AURKA at centrosomes', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	59	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'TPX2 promotes AURKA autophosphorylation', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDE1	genes/human/NDE1/NDE1-ai-review.yaml	NDE1	Q9NXR1	NCBITaxon:9606	Homo sapiens	60	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS for cytosol from the reaction 'EML4 recruits NUDC to mitotic spindle', where NDE1 is a member of the kinetochore or centrosome complex represented in the cytosolic compartment.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	126	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	127	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	128	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	129	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	130	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	131	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	132	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	133	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	134	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	135	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	136	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	137	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	138	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	139	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDEL1	genes/human/NDEL1/NDEL1-ai-review.yaml	NDEL1	Q9GZM8	NCBITaxon:9606	Homo sapiens	140	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NDEL1 in the cytosol as a participant in kinetochore/mitotic reactions.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	15	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) localization to mitochondrial inner membrane, from the Complex I electron-transfer reaction event. Correct localization for this inner-membrane subunit.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA1	genes/human/NDUFA1/NDUFA1-ai-review.yaml	NDUFA1	O15239	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	17	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from the Complex I catalytic reaction pathway. Consistent with the membrane-arm localization of NDUFA10.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis reaction. Redundant with other inner-membrane annotations; localization is correct.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis reaction. Localization correct; redundant with other inner-membrane annotations.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis reaction. Localization correct; redundant with other inner-membrane annotations.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from the final Complex I biogenesis step (assembly factors dissociate to yield mature Complex I). Localization correct.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis reaction. Localization correct; redundant with other inner-membrane annotations.
human	NDUFA10	genes/human/NDUFA10/NDUFA10-ai-review.yaml	NDUFA10	O95299	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis reaction. Localization correct; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	13	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) localization to mitochondrial inner membrane, from the Complex I electron-transfer reaction event. Correct localization for this inner-membrane subunit.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	14	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	15	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA11	genes/human/NDUFA11/NDUFA11-ai-review.yaml	NDUFA11	Q86Y39	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFA12	genes/human/NDUFA12/NDUFA12-ai-review.yaml	NDUFA12	Q9UI09	NCBITaxon:9606	Homo sapiens	20	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author localization to mitochondrial inner membrane. Correct and consistent with the experimental inner-membrane annotation; redundant.
human	NDUFA12	genes/human/NDUFA12/NDUFA12-ai-review.yaml	NDUFA12	Q9UI09	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author localization to mitochondrial inner membrane (Complex I biogenesis pathway). Consistent; redundant with the experimental annotation.
human	NDUFA12	genes/human/NDUFA12/NDUFA12-ai-review.yaml	NDUFA12	Q9UI09	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author localization to mitochondrial inner membrane. Consistent and correct; redundant with the experimental inner-membrane annotation.
human	NDUFA12	genes/human/NDUFA12/NDUFA12-ai-review.yaml	NDUFA12	Q9UI09	NCBITaxon:9606	Homo sapiens	23	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author localization to mitochondrial inner membrane. Consistent and correct; redundant with the experimental inner-membrane annotation.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	29	R-HSA-9839110	HTRA2 degrades NDUFA13 (GRIM-19)	yes	reactome/R-HSA-9839110.md	HTRA2 degrades NDUFA13 (GRIM-19)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	34	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	35	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	36	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	37	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	38	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	39	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	40	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA13	genes/human/NDUFA13/NDUFA13-ai-review.yaml	NDUFA13	Q9P0J0	NCBITaxon:9606	Homo sapiens	41	R-HSA-9839073	HTRA2 binds NDUFA13 (GRIM-19)	yes	reactome/R-HSA-9839073.md	HTRA2 binds NDUFA13 (GRIM-19)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization. Correct and core. Accept.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	15	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS inner-membrane localization from the Reactome reaction for mature Complex I oxidising NADH. Consistent with the experimentally supported inner-membrane localization. Correct and core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Consistent with NDUFA2 localization; a redundant assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from the Reactome reaction in which peripheral-arm subunits bind the 815 kDa complex during Complex I assembly. Consistent with NDUFA2 localization; assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Consistent with NDUFA2 localization; assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from the Reactome reaction in which assembly factors dissociate to yield mature Complex I. Consistent with NDUFA2 localization; assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I membrane-arm assembly reaction. Consistent with NDUFA2 localization; assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I subcomplex assembly reaction. Consistent with NDUFA2 localization; assembly-pathway restatement. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	22	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization derived from a Reactome LONP1 protein- degradation reaction (LONP1 binds mitochondrial inner-membrane proteins). The localization call is correct, but it comes from a model of NDUFA2 as a degradation substrate, not from an NDUFA2-function assay. Non-core.
human	NDUFA2	genes/human/NDUFA2/NDUFA2-ai-review.yaml	NDUFA2	O43678	NCBITaxon:9606	Homo sapiens	23	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization derived from a Reactome LONP1 degradation reaction (LONP1 degrades mitochondrial inner-membrane proteins). Localization is correct but originates from a substrate-of-degradation model. Non-core.
human	NDUFA4	genes/human/NDUFA4/NDUFA4-ai-review.yaml	NDUFA4	O00483	NCBITaxon:9606	Homo sapiens	17	R-HSA-163214	Electron transfer from reduced cytochrome c to molecular oxygen	yes	reactome/R-HSA-163214.md	Electron transfer from reduced cytochrome c to molecular oxygen	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for electron transfer from reduced cytochrome c to molecular oxygen, documenting Complex IV at the inner mitochondrial membrane.
human	NDUFA4	genes/human/NDUFA4/NDUFA4-ai-review.yaml	NDUFA4	O00483	NCBITaxon:9606	Homo sapiens	18	R-HSA-9709406	CO binds to Cytochrome c oxidase	yes	reactome/R-HSA-9709406.md	CO binds to Cytochrome c oxidase	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction documenting CO binding to cytochrome c oxidase at the inner membrane.
human	NDUFA4	genes/human/NDUFA4/NDUFA4-ai-review.yaml	NDUFA4	O00483	NCBITaxon:9606	Homo sapiens	19	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for Complex IV assembly -- MT-CO3, COX6A, COX6B, COX7A and NDUFA4 bind to the holo-MT-CO1,2 complex at the inner membrane. This directly documents NDUFA4 incorporation into CIV.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	22	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome traceable-author-statement placing NDUFA5 at the mitochondrial inner membrane in the ""Complex I oxidises NADH"" reaction. Correct localization; redundant with the experimental IDA to the same term. Keep as non-core."
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	27	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA5	genes/human/NDUFA5/NDUFA5-ai-review.yaml	NDUFA5	Q16718	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (Complex I biogenesis step) for mitochondrial inner membrane localization. Correct but redundant with the experimental IDA row. Keep as non-core.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	14	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-derived location annotation (Complex I oxidises NADH to NAD+). Correct localization; one of several redundant Reactome TAS annotations to the same term.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	15	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA6	genes/human/NDUFA6/NDUFA6-ai-review.yaml	NDUFA6	P56556	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction. Correct inner-membrane localization; redundant with the other inner-membrane annotations.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	23	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from Reactome (Complex I oxidises NADH to NAD+ reaction). Accurate location for a Complex I subunit; redundant with the experimental inner-membrane annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	27	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA8	genes/human/NDUFA8/NDUFA8-ai-review.yaml	NDUFA8	P51970	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I assembly reaction. Correct location; redundant with experimental annotations. Non-core.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	28	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS localization to mitochondrial matrix for the Complex I reaction ""Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2"". As with the other matrix annotations, NDUFA9 is a subunit of inner-membrane Complex I whose peripheral arm faces the matrix; the more precise location is the mitochondrial inner membrane (GO:0005743)."
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	32	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	33	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	34	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	35	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS matrix localization associated with a Complex I biogenesis reaction. Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location.
human	NDUFA9	genes/human/NDUFA9/NDUFA9-ai-review.yaml	NDUFA9	Q16795	NCBITaxon:9606	Homo sapiens	36	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS matrix localization associated with a Complex I biogenesis reaction (""NDUF subunits bind to form the IP subcomplex""). Redundant with the other matrix annotations; NDUFA9 is an inner-membrane Complex I subunit and GO:0005743 is the preferred location."
human	NDUFAF1	genes/human/NDUFAF1/NDUFAF1-ai-review.yaml	NDUFAF1	Q9Y375	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable (TAS, Reactome) inner-membrane localization within the complex I biogenesis pathway. Consistent with NDUFAF1's peripheral association with the matrix face of the inner membrane during assembly. Kept as non-core.
human	NDUFAF1	genes/human/NDUFAF1/NDUFAF1-ai-review.yaml	NDUFAF1	Q9Y375	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable (TAS, Reactome) inner-membrane localization, from the pathway step in which the MCIA complex dissociates from the maturing complex I. Consistent with peripheral inner-membrane association during assembly. Kept as non-core.
human	NDUFAF1	genes/human/NDUFAF1/NDUFAF1-ai-review.yaml	NDUFAF1	Q9Y375	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable (TAS, Reactome) inner-membrane localization within the complex I biogenesis pathway. Consistent with the peripheral inner-membrane association of NDUFAF1 during membrane-arm assembly. Kept as non-core.
human	NDUFAF1	genes/human/NDUFAF1/NDUFAF1-ai-review.yaml	NDUFAF1	Q9Y375	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799199	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex	yes	reactome/R-HSA-6799199.md	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable (TAS, Reactome) inner-membrane localization from the step in which COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6 and NDUFB6 bind the MCIA complex. Consistent with peripheral inner-membrane association during assembly. Kept as non-core.
human	NDUFAF1	genes/human/NDUFAF1/NDUFAF1-ai-review.yaml	NDUFAF1	Q9Y375	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable (TAS, Reactome) inner-membrane localization within the complex I biogenesis pathway. Consistent with peripheral inner-membrane association of NDUFAF1 during assembly. Kept as non-core.
human	NDUFAF2	genes/human/NDUFAF2/NDUFAF2-ai-review.yaml	NDUFAF2	Q8N183	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Traceable author statement (Reactome) placing NDUFAF2 at the mitochondrial inner membrane, the site of complex I assembly, where it associates with the membrane-embedded assembly intermediate. This is a more specific and biologically appropriate location than the generic InterPro ""membrane"" term. Accept."
human	NDUFAF2	genes/human/NDUFAF2/NDUFAF2-ai-review.yaml	NDUFAF2	Q8N183	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial inner membrane localization, from the complex I biogenesis pathway step in which the assembly factors (including NDUFAF2) dissociate from the 980 kDa complex. Consistent with its transient inner-membrane-associated assembly role. Accept.
human	NDUFAF2	genes/human/NDUFAF2/NDUFAF2-ai-review.yaml	NDUFAF2	Q8N183	NCBITaxon:9606	Homo sapiens	18	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial inner membrane localization (FP subcomplex assembly step). Redundant with the other two Reactome inner-membrane annotations but consistent with the assembly site. Accept.
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	14	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from the ""Complex I biogenesis"" pathway (step: Intermediate 1 binds HP subcomplex to form Intermediate 2). Consistent with the experimentally supported inner membrane location where NDUFAF3 acts. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	15	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from a ""Complex I biogenesis"" assembly step. Consistent with the experimentally supported inner membrane location. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from a ""Complex I biogenesis"" assembly step. Consistent with the experimentally supported inner membrane location. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from the ""Complex I biogenesis"" step in which the MCIA complex and assembly factors (NDUFAF2-7, TIMMDC1) dissociate from the 980kDa complex to leave mature complex I. Consistent with the inner membrane location and with NDUFAF3 being a transient assembly factor that leaves the mature enzyme. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from a ""Complex I biogenesis"" assembly step. Consistent with the experimentally supported inner membrane location. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from a ""Complex I biogenesis"" assembly step. Consistent with the experimentally supported inner membrane location. Accept."
human	NDUFAF3	genes/human/NDUFAF3/NDUFAF3-ai-review.yaml	NDUFAF3	Q9BU61	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from the ""Complex I biogenesis"" step in which the IP subcomplex binds NDUFAF3, NDUFAF4 and TIMMDC1 to form Intermediate 1. This is the assembly step in which NDUFAF3 directly participates. Consistent with the inner membrane location. Accept."
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Author-stated (Reactome ""Complex I biogenesis"") localization to the mitochondrial inner membrane, where NDUFAF4 acts on the membrane-arm assembly intermediate. Specific and correct location; accept."
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization within the complex I biogenesis pathway. Correct and specific; accept.
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization within the complex I biogenesis pathway. Correct and specific; accept.
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization within the complex I biogenesis pathway (dissociation of assembly factors from the near-mature complex). Correct and specific; accept.
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization within the complex I biogenesis pathway. Correct and specific; accept.
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization within the complex I biogenesis pathway. Correct and specific; accept.
human	NDUFAF4	genes/human/NDUFAF4/NDUFAF4-ai-review.yaml	NDUFAF4	Q9P032	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome-curated inner-membrane localization; this reaction is where the IP subcomplex binds NDUFAF3, NDUFAF4, and TIMMDC1 to form an early membrane-arm intermediate (""Intermediate 1""). Directly on the core assembly step; accept."
human	NDUFAF5	genes/human/NDUFAF5/NDUFAF5-ai-review.yaml	NDUFAF5	Q5TEU4	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to the inner membrane within the Complex I biogenesis pathway. Correct.
human	NDUFAF5	genes/human/NDUFAF5/NDUFAF5-ai-review.yaml	NDUFAF5	Q5TEU4	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable localization to the inner membrane (MT-ND1:NDUFAF5:NDUFAF6 assembly intermediate). Correct.
human	NDUFAF5	genes/human/NDUFAF5/NDUFAF5-ai-review.yaml	NDUFAF5	Q5TEU4	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable inner-membrane localization within Complex I biogenesis. Correct.
human	NDUFAF5	genes/human/NDUFAF5/NDUFAF5-ai-review.yaml	NDUFAF5	Q5TEU4	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable inner-membrane localization within Complex I biogenesis. Correct.
human	NDUFAF5	genes/human/NDUFAF5/NDUFAF5-ai-review.yaml	NDUFAF5	Q5TEU4	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable inner-membrane localization within Complex I biogenesis. Correct.
human	NDUFAF6	genes/human/NDUFAF6/NDUFAF6-ai-review.yaml	NDUFAF6	Q330K2	NCBITaxon:9606	Homo sapiens	7	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing NDUFAF6 at the mitochondrial inner membrane within the Complex I biogenesis pathway. Consistent with the experimentally supported location; one of several redundant Reactome-derived inner-membrane annotations.
human	NDUFAF6	genes/human/NDUFAF6/NDUFAF6-ai-review.yaml	NDUFAF6	Q330K2	NCBITaxon:9606	Homo sapiens	8	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation from the Complex I biogenesis pathway; the reaction involves the MT-ND1:NDUFAF5:NDUFAF6 subcomplex, directly reflecting the ND1-related assembly role of NDUFAF6 at the inner membrane. Accurate; redundant with the other inner-membrane annotations.
human	NDUFAF6	genes/human/NDUFAF6/NDUFAF6-ai-review.yaml	NDUFAF6	Q330K2	NCBITaxon:9606	Homo sapiens	9	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Complex I biogenesis pathway) supporting inner-membrane localization. Accurate but redundant with the IDA and other Reactome inner-membrane annotations.
human	NDUFAF6	genes/human/NDUFAF6/NDUFAF6-ai-review.yaml	NDUFAF6	Q330K2	NCBITaxon:9606	Homo sapiens	10	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Complex I biogenesis pathway) supporting inner-membrane localization. Accurate but redundant with the other inner-membrane annotations.
human	NDUFAF6	genes/human/NDUFAF6/NDUFAF6-ai-review.yaml	NDUFAF6	Q330K2	NCBITaxon:9606	Homo sapiens	11	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Complex I biogenesis pathway) supporting inner-membrane localization. Accurate but redundant with the other inner-membrane annotations.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (Complex I biogenesis pathway) localizes NDUFAF7 to the mitochondrial matrix, consistent with the experimentally confirmed matrix localization. This is the most precise correct compartment term.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from the Complex I biogenesis reaction in which the MCIA complex and NDUFAF2-7 dissociate from the 980kDa complex; concordant with the experimentally confirmed matrix localization and with NDUFAF7 acting as a transient (non-structural) assembly factor.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFAF7	genes/human/NDUFAF7/NDUFAF7-ai-review.yaml	NDUFAF7	Q7L592	NCBITaxon:9606	Homo sapiens	25	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome matrix localization from a Complex I biogenesis reaction; concordant with experimental data.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	20	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation for the inner-membrane location in the context of the Complex I NADH to NAD+/CoQ reaction. Correct localization, redundant with experimental IDA/IMP annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB10	genes/human/NDUFB10/NDUFB10-ai-review.yaml	NDUFB10	O96000	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation (Complex I biogenesis) for the inner-membrane location. Correct, redundant with experimental annotations.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	17	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location associated with the Complex-I catalytic reaction. Correct location; redundant with the EXP/IDA/IEA rows. Retained as non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from a Complex I biogenesis reaction. Correct but redundant location annotation. Non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from a Complex I biogenesis reaction. Correct but redundant location annotation. Non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from a Complex I biogenesis reaction. Correct but redundant location annotation. Non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from the Complex I biogenesis pathway (final assembly step). Correct but redundant location annotation. Non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from a Complex I biogenesis reaction. Correct but redundant location annotation. Non-core.
human	NDUFB11	genes/human/NDUFB11/NDUFB11-ai-review.yaml	NDUFB11	Q9NX14	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (TAS) inner-membrane location from a Complex I biogenesis reaction. Correct but redundant location annotation. Non-core.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	16	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) localization to mitochondrial inner membrane, from the Complex I electron-transfer reaction event. Correct localization for this inner-membrane subunit.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB3	genes/human/NDUFB3/NDUFB3-ai-review.yaml	NDUFB3	O43676	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	19	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization asserted by Reactome (Complex I redox reaction). Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB7	genes/human/NDUFB7/NDUFB7-ai-review.yaml	NDUFB7	P17568	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS inner-membrane localization from a Reactome Complex I biogenesis reaction. Correct and redundant with the experimental inner-membrane annotations. Retained as supporting (non-core-duplicating).
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	17	R-HSA-8986181	PITRM1 proteolyzes mitochondrial targeting peptides (presequences)	yes	reactome/R-HSA-8986181.md	PITRM1 proteolyzes mitochondrial targeting peptides (presequences)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	TAS (Reactome) localization to mitochondrial matrix. This derives from the mitochondrial protein-import pathway step (PITRM1 processing of targeting presequences), reflecting the transient matrix exposure of the imported precursor rather than the steady-state location of the mature protein. The mature NDUFB8 is an inner-membrane subunit with a matrix-facing soluble domain; a standalone matrix annotation mislocates the functional protein.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	18	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to mitochondrial inner membrane, from the Complex I catalytic reaction event. Correct core localization for this inner-membrane Complex I subunit; redundant with the IDA/IEA inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis (assembly intermediate) event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis event (dissociation of assembly factors to yield mature Complex I). Correct localization; redundant with other inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB8	genes/human/NDUFB8/NDUFB8-ai-review.yaml	NDUFB8	O95169	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization from a Complex I biogenesis event. Correct localization; redundant with other inner-membrane annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	23	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from the reaction in which Complex I oxidises NADH and reduces CoQ. Correct location; consistent with experimental IDA annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct location; consistent with the experimental annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct and consistent with experimental annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct and consistent with experimental annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	27	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct and consistent with experimental annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct and consistent with experimental annotations.
human	NDUFB9	genes/human/NDUFB9/NDUFB9-ai-review.yaml	NDUFB9	Q9Y6M9	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) inner-membrane localization, from a Complex I biogenesis reaction. Correct and consistent with experimental annotations.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	22	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome (TAS) plasma membrane localization arising from a neutrophil degranulation (""Exocytosis of azurophil granule membrane proteins"") pathway. NDUFC2 is a bona fide mitochondrial inner-membrane Complex I subunit; a plasma-membrane location is not supported and reflects bulk-pathway over-inclusion. Over-annotation."
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	23	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) azurophil granule membrane localization from the same neutrophil degranulation pathway. Azurophil (primary) granules are myeloperoxidase-rich secretory granules; placing a mitochondrial Complex I subunit there is biologically implausible and reflects pathway over-inclusion. Over-annotation.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	24	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from the Complex I catalytic reaction event. Correct core localization; redundant with the experimental IDA annotations.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	25	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant with experimental annotations to the same term.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	27	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant.
human	NDUFC2	genes/human/NDUFC2/NDUFC2-ai-review.yaml	NDUFC2	O95298	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) mitochondrial inner membrane localization from a Complex I biogenesis step. Correct core localization; redundant.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	40	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for mitochondrial matrix localization, based on the Complex I NADH oxidation reaction. NDUFS1 is a peripheral membrane protein on the matrix side of Complex I. UniProt states NDUFS1 is on the matrix side of the inner membrane.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	41	R-HSA-6788523	NUBPL transfers 4Fe-4S to Complex I subunits	yes	reactome/R-HSA-6788523.md	NUBPL transfers 4Fe-4S to Complex I subunits	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for mitochondrial matrix localization, associated with NUBPL-mediated 4Fe-4S cluster transfer to Complex I subunits. NDUFS1 receives its Fe-S clusters in the mitochondrial matrix.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	42	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with peripheral arm subunits binding to the 815 kDa complex to form a 980 kDa complex during Complex I assembly.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	43	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with the MCIA complex and NDUFAF2-7 dissociation from the 980 kDa complex to yield mature Complex I.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	44	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with NDUF subunits binding to form the FP subcomplex.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	45	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with CLPXP binding mitochondrial matrix proteins. This reflects the general mitochondrial matrix localization of NDUFS1 in the context of mitochondrial quality control/protein degradation.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	46	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with LONP1 degradation of mitochondrial matrix proteins. Reflects NDUFS1 as a LONP1 substrate in the matrix.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	47	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with LONP1 binding mitochondrial matrix proteins.
human	NDUFS1	genes/human/NDUFS1/NDUFS1-ai-review.yaml	NDUFS1	P28331	NCBITaxon:9606	Homo sapiens	48	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with CLPXP degradation of mitochondrial matrix proteins.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	53	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for Complex I oxidation of NADH. NDUFS2 is a peripheral membrane protein on the matrix side of the inner membrane. UniProt confirms subcellular location as mitochondrion inner membrane, matrix side.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	54	R-HSA-6788523	NUBPL transfers 4Fe-4S to Complex I subunits	yes	reactome/R-HSA-6788523.md	NUBPL transfers 4Fe-4S to Complex I subunits	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for NUBPL transfer of 4Fe-4S clusters to Complex I subunits. NDUFS2 receives its [4Fe-4S] cluster in the mitochondrial matrix during assembly.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	55	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome Complex I assembly pathway. NDUFS2 is part of assembly intermediates that form in the mitochondrial matrix.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	56	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome Complex I assembly pathway for peripheral arm subunit binding.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	57	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for Intermediate 2 binding MT-ND1 subcomplex in the assembly pathway.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	58	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for dissociation of assembly factors from the 980kDa complex to yield mature Complex I.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	59	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for ND4/ND5 binding to the 550kDa assembly complex.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	60	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for the 315kDa and 370kDa subcomplexes combining to form the 550kDa complex during assembly.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	61	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for IP subcomplex binding NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1. NDUFS2 is part of the IP (iron-sulfur protein) subcomplex.
human	NDUFS2	genes/human/NDUFS2/NDUFS2-ai-review.yaml	NDUFS2	O75306	NCBITaxon:9606	Homo sapiens	62	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for NDUF subunits binding to form the IP subcomplex. NDUFS2 is a core component of this initial assembly step.
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	35	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix, from the reaction in which Complex I oxidizes NADH and reduces CoQ. NDUFS3 is a matrix-side peripheral-arm subunit, so the matrix location is compatible, though the primary curated anatomical location is the inner membrane (GO:0005743).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	36	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (Intermediate 1 binds HP subcomplex to form Intermediate 2).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	37	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (peripheral arm subunits bind the 815 kDa complex).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	38	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	39	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (dissociation of assembly factors to form Complex I).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	40	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (ND4, ND5 bind the 550 kDa complex).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	41	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (315 kDa binds 370 kDa to form 550 kDa complex).
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	42	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a Complex I biogenesis reaction (IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1). NDUFS3 is part of the IP subcomplex referenced here.
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	43	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from the reaction forming the IP subcomplex, of which NDUFS3 is a component.
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	44	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a mitochondrial protein quality-control reaction (CLPXP binds matrix proteins). This reflects NDUFS3 as a potential CLPXP substrate rather than a Complex I function.
human	NDUFS3	genes/human/NDUFS3/NDUFS3-ai-review.yaml	NDUFS3	O75489	NCBITaxon:9606	Homo sapiens	45	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to the mitochondrial matrix from a mitochondrial protein quality-control reaction (CLPXP degrades matrix proteins).
human	NDUFS4	genes/human/NDUFS4/NDUFS4-ai-review.yaml	NDUFS4	O43181	NCBITaxon:9606	Homo sapiens	22	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-163217 (Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2). NDUFS4 is annotated as part of Complex I which functions at the mitochondrial inner membrane. This is consistent with all structural and biochemical evidence.
human	NDUFS4	genes/human/NDUFS4/NDUFS4-ai-review.yaml	NDUFS4	O43181	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6799179 (Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex). This Reactome entry describes the assembly step where peripheral arm subunits including NDUFS4 are incorporated into the growing Complex I at the inner membrane.
human	NDUFS4	genes/human/NDUFS4/NDUFS4-ai-review.yaml	NDUFS4	O43181	NCBITaxon:9606	Homo sapiens	24	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6799196 (The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I). This represents the final maturation step of Complex I assembly where assembly factors dissociate. NDUFS4 is critical for this step, as its incorporation helps displace NDUFAF2.
human	NDUFS4	genes/human/NDUFS4/NDUFS4-ai-review.yaml	NDUFS4	O43181	NCBITaxon:9606	Homo sapiens	25	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-6800870 (NDUF subunits bind to form the FP subcomplex). This refers to early assembly of the flavoprotein subcomplex. NDUFS4 is part of the iron-sulfur protein fragment rather than the FP subcomplex, but the overall annotation of inner membrane localization is still correct.
human	NDUFS6	genes/human/NDUFS6/NDUFS6-ai-review.yaml	NDUFS6	O75380	NCBITaxon:9606	Homo sapiens	18	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (TAS, Reactome) localisation to the mitochondrial inner membrane, from the Reactome reaction in which Complex I oxidises NADH and reduces CoQ. Correct location.
human	NDUFS6	genes/human/NDUFS6/NDUFS6-ai-review.yaml	NDUFS6	O75380	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (TAS, Reactome) localisation to the mitochondrial inner membrane, from a Complex I assembly reaction (peripheral arm subunits binding the 815 kDa intermediate). Correct location.
human	NDUFS6	genes/human/NDUFS6/NDUFS6-ai-review.yaml	NDUFS6	O75380	NCBITaxon:9606	Homo sapiens	20	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (TAS, Reactome) localisation to the mitochondrial inner membrane, from the final Complex I biogenesis reaction (dissociation of assembly factors yielding mature Complex I). Correct location.
human	NDUFS6	genes/human/NDUFS6/NDUFS6-ai-review.yaml	NDUFS6	O75380	NCBITaxon:9606	Homo sapiens	21	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (TAS, Reactome) localisation to the mitochondrial inner membrane, from the reaction in which NDUF subunits assemble into the FP subcomplex. Correct location.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	26	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The peripheral (IP) arm of Complex I, which contains NDUFS7, protrudes into the mitochondrial matrix; NDUFS7 is a matrix-side peripheral membrane protein.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	27	R-HSA-6788523	NUBPL transfers 4Fe-4S to Complex I subunits	yes	reactome/R-HSA-6788523.md	NUBPL transfers 4Fe-4S to Complex I subunits	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway (NUBPL transfers 4Fe-4S to Complex I subunits) locating Complex I assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	32	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	33	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	34	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction, locating assembly intermediates in the matrix.
human	NDUFS7	genes/human/NDUFS7/NDUFS7-ai-review.yaml	NDUFS7	O75251	NCBITaxon:9606	Homo sapiens	35	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Complex I biogenesis reaction (NDUF subunits bind to form the IP subcomplex), locating assembly intermediates in the matrix.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	24	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix. NDUFS8 is an inner-membrane peripheral subunit facing the matrix; the matrix assignment is a coarse localization that is less precise than the annotated inner-membrane location.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	25	R-HSA-6788523	NUBPL transfers 4Fe-4S to Complex I subunits	yes	reactome/R-HSA-6788523.md	NUBPL transfers 4Fe-4S to Complex I subunits	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (from a Complex I biogenesis reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	26	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly intermediate reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	27	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	28	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	32	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (Complex I assembly reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFS8	genes/human/NDUFS8/NDUFS8-ai-review.yaml	NDUFS8	O00217	NCBITaxon:9606	Homo sapiens	33	R-HSA-6800868	NDUF subunits bind to form the IP subcomplex	yes	reactome/R-HSA-6800868.md	NDUF subunits bind to form the IP subcomplex	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to mitochondrial matrix (IP subcomplex formation reaction). Coarse localization for an inner-membrane peripheral subunit.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	33	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-163217 (Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2). NDUFV1 is part of Complex I which is embedded in the inner mitochondrial membrane.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	34	R-HSA-6788556	NUBPL transfers 4Fe-4S to NDUFV1, V2	yes	reactome/R-HSA-6788556.md	NUBPL transfers 4Fe-4S to NDUFV1, V2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-6788556 (NUBPL transfers 4Fe-4S to NDUFV1, V2). This Reactome entry specifically describes the iron-sulfur cluster insertion into NDUFV1 and NDUFV2, placing NDUFV1 at the inner membrane during assembly.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	35	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-6799179 (Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex). This describes Complex I assembly where peripheral arm subunits including NDUFV1 join the membrane-anchored subcomplex.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	36	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-6799196 (The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I). This describes the final maturation step of Complex I at the inner membrane.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	37	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-6800870 (NDUF subunits bind to form the FP subcomplex). This describes the assembly of the flavoprotein subcomplex (NDUFV1 + NDUFV2 + NDUFV3) that constitutes the N-module of Complex I.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	38	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-9837978 (LONP1 binds mitochondrial inner membrane proteins). This describes the mitochondrial protease LONP1 binding to inner membrane proteins including Complex I subunits for quality control.
human	NDUFV1	genes/human/NDUFV1/NDUFV1-ai-review.yaml	NDUFV1	P49821	NCBITaxon:9606	Homo sapiens	39	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome entry R-HSA-9838004 (LONP1 degrades mitochondrial inner membrane proteins). This describes LONP1-mediated degradation of inner membrane proteins including Complex I subunits.
human	NDUFV2	genes/human/NDUFV2/NDUFV2-ai-review.yaml	NDUFV2	P19404	NCBITaxon:9606	Homo sapiens	27	R-HSA-163217	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	yes	reactome/R-HSA-163217.md	Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived (TAS) annotation to the mitochondrial inner membrane, from the pathway event in which Complex I oxidises NADH and reduces ubiquinone. Correct location for this Complex I subunit.
human	NDUFV2	genes/human/NDUFV2/NDUFV2-ai-review.yaml	NDUFV2	P19404	NCBITaxon:9606	Homo sapiens	28	R-HSA-6788556	NUBPL transfers 4Fe-4S to NDUFV1, V2	yes	reactome/R-HSA-6788556.md	NUBPL transfers 4Fe-4S to NDUFV1, V2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived (TAS) annotation to the mitochondrial inner membrane, from a Complex I biogenesis event (Fe-S transfer to NDUFV1/V2). Correct location.
human	NDUFV2	genes/human/NDUFV2/NDUFV2-ai-review.yaml	NDUFV2	P19404	NCBITaxon:9606	Homo sapiens	29	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived (TAS) annotation to the mitochondrial inner membrane, from a Complex I assembly event. Correct location.
human	NDUFV2	genes/human/NDUFV2/NDUFV2-ai-review.yaml	NDUFV2	P19404	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived (TAS) annotation to the mitochondrial inner membrane, from a Complex I assembly event. Correct location.
human	NDUFV2	genes/human/NDUFV2/NDUFV2-ai-review.yaml	NDUFV2	P19404	NCBITaxon:9606	Homo sapiens	31	R-HSA-6800870	NDUF subunits bind to form the FP subcomplex	yes	reactome/R-HSA-6800870.md	NDUF subunits bind to form the FP subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-derived (TAS) annotation to the mitochondrial inner membrane, from the event in which NDUF subunits bind to form the FP subcomplex. Correct location for NDUFV2, which is part of the FP subcomplex.
human	NEK1	genes/human/NEK1/NEK1-ai-review.yaml	NEK1	Q96PY6	NCBITaxon:9606	Homo sapiens	28	R-HSA-9861642	NEK1 phosphorylates ME1	yes	reactome/R-HSA-9861642.md	NEK1 phosphorylates ME1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NEK1 acts in the cytosol, including phosphorylation of cytosolic ME1 in the curated Reactome reaction.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	10	R-HSA-9948318	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9948318.md	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	11	R-HSA-9948360	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9948360.md	NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	12	R-HSA-9948362	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9948362.md	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	13	R-HSA-9948427	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	14	R-HSA-9948458	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9948458.md	"NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide (""CAT tailing"")"	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	15	R-HSA-9954723	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9954723.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEMF	genes/human/NEMF/NEMF-ai-review.yaml	NEMF	O60524	NCBITaxon:9606	Homo sapiens	16	R-HSA-9954727	Reactome: NEMF cytosol localization	yes	reactome/R-HSA-9954727.md	RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of NEMF cytosolic localization.
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	13	R-HSA-4084999	NEU1 hydrolyses Neu5Ac from glycoconjugates	yes	reactome/R-HSA-4084999.md	NEU1 hydrolyses Neu5Ac from glycoconjugates	Homo sapiens	GO:0004308	exo-alpha-sialidase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for NEU1 hydrolysing Neu5Ac from glycoconjugates in the lysosomal multienzyme complex. Correct core molecular function.
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS reflecting release of NEU1 from neutrophil specific granules on degranulation (exocytosis of specific granule lumen proteins). A genuine but peripheral, cell-type-specific localization, not the core catabolic site.
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS placing NEU1 in the neutrophil specific-granule lumen (as degranulation cargo). Real but peripheral to the core lysosomal function.
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	22	R-HSA-4341669	Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates	yes	reactome/R-HSA-4341669.md	Defective NEU1 does not hydrolyse Neu5Ac from glycoconjugates	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	"Reactome TAS for the luminal lysosomal localization (in the context of the ""defective NEU1"" sialidosis reaction). Consistent with the core luminal location."
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	28	R-HSA-1605724	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	yes	reactome/R-HSA-1605724.md	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the luminal lysosomal localization in the context of NEU1/NEU4 hydrolysis of ganglioside GM3. Consistent with the core luminal location.
human	NEU1	genes/human/NEU1/NEU1-ai-review.yaml	NEU1	Q99519	NCBITaxon:9606	Homo sapiens	29	R-HSA-4084999	NEU1 hydrolyses Neu5Ac from glycoconjugates	yes	reactome/R-HSA-4084999.md	NEU1 hydrolyses Neu5Ac from glycoconjugates	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NEU1 in the lysosomal lumen where it hydrolyses Neu5Ac from glycoconjugates in the multienzyme complex. Core location (duplicates the other lysosomal-lumen annotations).
human	NEUROD1	genes/human/NEUROD1/NEUROD1-ai-review.yaml	NEUROD1	Q13562	NCBITaxon:9606	Homo sapiens	35	R-HSA-210920	NEUROG3-dependent synthesis of NEUROD1	yes	reactome/R-HSA-210920.md	NEUROG3-dependent synthesis of NEUROD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome pathway annotation for NEUROG3-dependent synthesis of NEUROD1.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	88	R-HSA-6802837	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	yes	reactome/R-HSA-6802837.md	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from Reactome pathway annotation.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	89	R-HSA-5658424	KBTBD7:CUL3:RBX1 ubiquitinates NF1	yes	reactome/R-HSA-5658424.md	KBTBD7:CUL3:RBX1 ubiquitinates NF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	90	R-HSA-5658430	NF1 is degraded by the proteasome	yes	reactome/R-HSA-5658430.md	NF1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome NF1 degradation pathway.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	97	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome RAS GAPs pathway.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	98	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome RAS binding pathway.
human	NF1	genes/human/NF1/NF1-ai-review.yaml	NF1	P21359	NCBITaxon:9606	Homo sapiens	99	R-HSA-5658438	SPRED dimer binds NF1	yes	reactome/R-HSA-5658438.md	SPRED dimer binds NF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome SPRED-NF1 pathway.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	92	R-HSA-9796067	PRKAA2 phosphorylates nuclear NRF2	yes	reactome/R-HSA-9796067.md	PRKAA2 phosphorylates nuclear NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	PRKAA2 phosphorylates nuclear NRF2.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	99	R-HSA-8932355	26S proteasome degrades ubiquitinated NRF2	yes	reactome/R-HSA-8932355.md	26S proteasome degrades Ub-NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	26S proteasome degrades ubiquitinated NRF2 in cytosol.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	100	R-HSA-9755505	KEAP1:CUL3:RBX1 complex ubiquitinates NRF2	yes	reactome/R-HSA-9755505.md	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	KEAP1:CUL3:RBX1 complex ubiquitinates NRF2 in cytosol.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	101	R-HSA-9755507	VCP/p97 complex extracts ubiquitinated NRF2 for degradation	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP/p97 complex extracts ubiquitinated NRF2 for degradation.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	102	R-HSA-9758090	Ubiquitinated NRF2 extraction from CRL3 complex	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Ubiquitinated NRF2 extraction from CRL3 complex.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	105	R-HSA-9796047	PRKAA2-regulated nuclear export of NRF2	yes	reactome/R-HSA-9796047.md	PRKAA2 regulated nuclear export of NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	PRKAA2-regulated nuclear export of NRF2.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	106	R-HSA-9796047	PRKAA2-regulated nuclear export of NRF2	yes	reactome/R-HSA-9796047.md	PRKAA2 regulated nuclear export of NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NRF2 in cytosol for export regulation.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	118	R-HSA-9796053	PKC phosphorylates NRF2 in cytosol	yes	reactome/R-HSA-9796053.md	PRKCI phosphorylates NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PKC phosphorylates NRF2 in cytosol.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	119	R-HSA-8932327	NRF2 binds KEAP1:NEDD8-CUL3:RBX1 in cytosol	yes	reactome/R-HSA-8932327.md	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NRF2 binds KEAP1:NEDD8-CUL3:RBX1 in cytosol.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	120	R-HSA-9712274	NRF2 inducers bind KEAP1:CUL3:RBX1:NRF2 in cytosol	yes	reactome/R-HSA-9712274.md	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NRF2 inducers bind KEAP1:CUL3:RBX1:NRF2 in cytosol.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	121	R-HSA-9762100	MYC and NICD1-dependent NFE2L2 gene expression	yes	reactome/R-HSA-9762100.md	MYC- and NICD1-dependent NFE2L2 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	MYC and NICD1-dependent NFE2L2 gene expression.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	122	R-HSA-9796046	NFkB-dependent NFE2L2 expression	yes	reactome/R-HSA-9796046.md	NFkB dependent NFE2L2 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NFkB-dependent NFE2L2 expression.
human	NFE2L2	genes/human/NFE2L2/NFE2L2-ai-review.yaml	NFE2L2	Q16236	NCBITaxon:9606	Homo sapiens	123	R-HSA-9796060	NFE2L2-dependent NFE2L2 expression (autoregulation)	yes	reactome/R-HSA-9796060.md	NFE2L2 dependent NFE2L2 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	NFE2L2-dependent NFE2L2 expression (autoregulation).
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	23	R-HSA-1362409	Mitochondrial iron-sulfur cluster biogenesis	yes	reactome/R-HSA-1362409.md	Mitochondrial iron-sulfur cluster biogenesis	Homo sapiens	GO:0016226	iron-sulfur cluster assembly	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for mitochondrial iron-sulfur cluster biogenesis.
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	43	R-HSA-947514	PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3	yes	reactome/R-HSA-947514.md	PXLP-K198-NFS1 transfers sulfur from cysteine onto MOCS3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NFS1-MOCS3 sulfur transfer in cytosol.
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	63	R-HSA-1362408	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	yes	reactome/R-HSA-1362408.md	FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NFS1 function in [2Fe-2S] cluster assembly in mitochondrial matrix.
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	64	R-HSA-1362416	Frataxin binds iron	yes	reactome/R-HSA-1362416.md	Frataxin binds iron	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for frataxin iron binding in mitochondrial matrix context with NFS1.
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	65	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome pathway for transfer of Fe-S clusters to SDHB in mitochondrial matrix.
human	NFS1	genes/human/NFS1/NFS1-ai-review.yaml	NFS1	Q9Y697	NCBITaxon:9606	Homo sapiens	66	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome pathway for [2Fe-2S] insertion into UQCRFS1 in mitochondrial matrix.
human	NFU1	genes/human/NFU1/NFU1-ai-review.yaml	NFU1	Q9UMS0	NCBITaxon:9606	Homo sapiens	21	R-HSA-6793591	LIAS synthesizes lipoyl-GCSH	yes	reactome/R-HSA-6793591.md	LIAS synthesizes lipoyl-GCSH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	The Reactome pathway for protein lipoylation places NFU1 in the mitochondrial matrix, where it functions to deliver [4Fe-4S] clusters to LIAS for lipoyl-GCSH synthesis.
human	NID1	genes/human/NID1/NID1-ai-review.yaml	NID1	P14543	NCBITaxon:9606	Homo sapiens	39	R-HSA-3791319	NID1 degradation by MMP19	yes	reactome/R-HSA-3791319.md	NID1 degradation by MMP19	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NID1 degradation by MMP19. Confirms extracellular localization.
human	NID1	genes/human/NID1/NID1-ai-review.yaml	NID1	P14543	NCBITaxon:9606	Homo sapiens	40	R-HSA-2426450	Laminins:Nidogens binds collagen type IV networks	yes	reactome/R-HSA-2426450.md	Laminins:Nidogens binds collagen type IV networks	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for Laminins-Nidogens binding collagen IV. Confirms extracellular localization.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	151	R-HSA-5691439	BRISC complex deubiquitinates NLRP3	yes	reactome/R-HSA-5691439.md	BRISC complex deubiquitinates NLRP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	169	R-HSA-1296421	NLRP3 oligomerizes via NACHT domains	yes	reactome/R-HSA-1296421.md	NLRP3 oligomerizes via NACHT domains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	170	R-HSA-1306876	NLRP3 activation by small molecules	yes	reactome/R-HSA-1306876.md	NLRP3 activation by small molecules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	171	R-HSA-844440	NLRP3 activation by elicitor proteins	yes	reactome/R-HSA-844440.md	NLRP3 activation by elicitor proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	172	R-HSA-844610	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction	yes	reactome/R-HSA-844610.md	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	173	R-HSA-844612	PYCARD recruits procaspase-1 via CARD	yes	reactome/R-HSA-844612.md	PYCARD recruits procaspase-1 via CARD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	174	R-HSA-873951	SGT1:HSP90 binds inactive NLRP3	yes	reactome/R-HSA-873951.md	SGT1:HSP90 binds inactive NLRP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	175	R-HSA-9603905	Expression of NLRP3 gene	yes	reactome/R-HSA-9603905.md	Expression of NLRP3 gene	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	176	R-HSA-9685268	SARS-CoV-1 8b binds NLRP3	yes	reactome/R-HSA-9685268.md	SARS-CoV-1 8b binds NLRP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	177	R-HSA-9685281	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome	yes	reactome/R-HSA-9685281.md	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRP3	genes/human/NLRP3/NLRP3-ai-review.yaml	NLRP3	Q96P20	NCBITaxon:9606	Homo sapiens	178	R-HSA-9757097	SARS-CoV-2 N binds NLRP3	yes	reactome/R-HSA-9757097.md	SARS-CoV-2 N binds NLRP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Resting NLRP3 is a soluble cytosolic protein, which is where it is held as an autoinhibited oligomer before activation.
human	NLRX1	genes/human/NLRX1/NLRX1-ai-review.yaml	NLRX1	Q86UT6	NCBITaxon:9606	Homo sapiens	11	R-HSA-9749471	NLRX1 binds CHUK:IKBKB:IKBKG	yes	reactome/R-HSA-9749471.md	NLRX1 binds CHUK:IKBKB:IKBKG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome pathway-step curation (NLRX1 binds CHUK:IKBKB:IKBKG) placing NLRX1 in the cytosol. NLRX1's dominant, experimentally established localization is the mitochondrial outer membrane.
human	NLRX1	genes/human/NLRX1/NLRX1-ai-review.yaml	NLRX1	Q86UT6	NCBITaxon:9606	Homo sapiens	12	R-HSA-936564	NLRX1 inhibits MAVS-DDX58 interaction	yes	reactome/R-HSA-936564.md	NLRX1 inhibits MAVS-DDX58 interaction	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation (NLRX1 inhibits MAVS-DDX58 interaction) placing NLRX1 at the mitochondrial outer membrane, consistent with the experimental localization and its MAVS-regulatory function. Core localization.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	44	R-HSA-482619	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)	yes	reactome/R-HSA-482619.md	(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. NME2 localizes to both cytosolic and nuclear compartments consistent with nucleotide homeostasis/signaling and gene regulation roles.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	45	R-HSA-482621	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)	yes	reactome/R-HSA-482621.md	(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. NME2 localizes to both cytosolic and nuclear compartments consistent with nucleotide homeostasis/signaling and gene regulation roles.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	46	R-HSA-9748969	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP	yes	reactome/R-HSA-9748969.md	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. NME2 localizes to both cytosolic and nuclear compartments consistent with nucleotide homeostasis/signaling and gene regulation roles.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	47	R-HSA-9748999	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP	yes	reactome/R-HSA-9748999.md	NME1:2 hexamer phosphorylates 6TGDP to 6TGTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. NME2 localizes to both cytosolic and nuclear compartments consistent with nucleotide homeostasis/signaling and gene regulation roles.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	48	R-HSA-9755013	NME1,2 hexamers phosphorylate RBV-DP	yes	reactome/R-HSA-9755013.md	NME1,2 hexamers phosphorylate RBV-DP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct. NME2 localizes to both cytosolic and nuclear compartments consistent with nucleotide homeostasis/signaling and gene regulation roles.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	59	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Extracellular or granule/exosome detection is observed in some contexts but is secondary to nucleo-cytosolic NME2 functions.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	60	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Extracellular or granule/exosome detection is observed in some contexts but is secondary to nucleo-cytosolic NME2 functions.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	61	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Extracellular or granule/exosome detection is observed in some contexts but is secondary to nucleo-cytosolic NME2 functions.
human	NME2	genes/human/NME2/NME2-ai-review.yaml	NME2	P22392	NCBITaxon:9606	Homo sapiens	62	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Kept as non-core. Extracellular or granule/exosome detection is observed in some contexts but is secondary to nucleo-cytosolic NME2 functions.
human	NMNAT1	genes/human/NMNAT1/NMNAT1-ai-review.yaml	NMNAT1	Q9HAN9	NCBITaxon:9606	Homo sapiens	38	R-HSA-200512	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD	yes	reactome/R-HSA-200512.md	NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasm location for the NMNAT1 NaMN->NaAD reaction. Consistent with nuclear localization.
human	NMNAT2	genes/human/NMNAT2/NMNAT2-ai-review.yaml	NMNAT2	Q9BZQ4	NCBITaxon:9606	Homo sapiens	27	R-HSA-197235	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD	yes	reactome/R-HSA-197235.md	NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement (NMNAT2 NaMN -> NaAD reaction) placing the enzyme at the cytoplasmic face of the Golgi membrane. Consistent with the experimental Golgi localization; core location.
human	NMNAT2	genes/human/NMNAT2/NMNAT2-ai-review.yaml	NMNAT2	Q9BZQ4	NCBITaxon:9606	Homo sapiens	28	R-HSA-8939959	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+	yes	reactome/R-HSA-8939959.md	NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement (NMNAT2 NMN -> NAD+ reaction) placing the enzyme at the Golgi membrane. Consistent with the experimental Golgi localization; core location.
human	NMNAT3	genes/human/NMNAT3/NMNAT3-ai-review.yaml	NMNAT3	Q96T66	NCBITaxon:9606	Homo sapiens	26	R-HSA-200474	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD	yes	reactome/R-HSA-200474.md	NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) places the NMNAT3-catalyzed NaMN to NaAD reaction in the mitochondrial matrix, the expected sub-compartment for this soluble enzyme. A more specific, well-supported location than mitochondrion; accepted.
human	NMRK1	genes/human/NMRK1/NMRK1-ai-review.yaml	NMRK1	Q9NWW6	NCBITaxon:9606	Homo sapiens	10	R-HSA-196807	Nicotinate metabolism	yes	reactome/R-HSA-196807.md	Nicotinate metabolism	Homo sapiens	GO:1901847	nicotinate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome curator-authored (TAS) placement of NMRK1 in nicotinate metabolism is correct: NMRK1 phosphorylates nicotinic acid riboside within the nicotinate branch of NAD+ salvage. Broad process term; keep as non-core supporting context.
human	NMRK1	genes/human/NMRK1/NMRK1-ai-review.yaml	NMRK1	Q9NWW6	NCBITaxon:9606	Homo sapiens	18	R-HSA-8869606	NMRK1 phosphorylates NAR to yield NAMN	yes	reactome/R-HSA-8869606.md	NMRK1 phosphorylates NAR to yield NAMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome reaction ""NMRK1 phosphorylates NAR to yield NAMN"" is annotated as cytosolic; correct localization for this soluble enzyme."
human	NMRK1	genes/human/NMRK1/NMRK1-ai-review.yaml	NMRK1	Q9NWW6	NCBITaxon:9606	Homo sapiens	19	R-HSA-8869633	NMRK1 phosphorylates NR to yield NMN	yes	reactome/R-HSA-8869633.md	NMRK1 phosphorylates NR to yield NMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome reaction ""NMRK1 phosphorylates NR to yield NMN"" is annotated as cytosolic; correct localization for this soluble enzyme."
human	NMRK2	genes/human/NMRK2/NMRK2-ai-review.yaml	NMRK2	Q9NPI5	NCBITaxon:9606	Homo sapiens	9	R-HSA-196807	Nicotinate metabolism	yes	reactome/R-HSA-196807.md	Nicotinate metabolism	Homo sapiens	GO:1901847	nicotinate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome TAS placing NMRK2 in nicotinate metabolism. Correct but a broad parent of the specific NAD+ salvage-biosynthesis process.
human	NMRK2	genes/human/NMRK2/NMRK2-ai-review.yaml	NMRK2	Q9NPI5	NCBITaxon:9606	Homo sapiens	16	R-HSA-8869607	NMRK2 phosphorylates NAR to yield NAMN	yes	reactome/R-HSA-8869607.md	NMRK2 phosphorylates NAR to yield NAMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation for the NMRK2-catalyzed NaR->NAMN reaction. Correct core localization.
human	NMRK2	genes/human/NMRK2/NMRK2-ai-review.yaml	NMRK2	Q9NPI5	NCBITaxon:9606	Homo sapiens	17	R-HSA-8869627	NMRK2 phosphorylates NR to yield NMN	yes	reactome/R-HSA-8869627.md	NMRK2 phosphorylates NR to yield NMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation for the NMRK2-catalyzed NR->NMN reaction. Correct core localization.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	165	R-HSA-2220978	FBXW7 WD mutants do not bind NICD1	yes	reactome/R-HSA-2220978.md	FBXW7 WD mutants do not bind NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	175	R-HSA-2660815	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4	yes	reactome/R-HSA-2660815.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	176	R-HSA-2660816	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2	yes	reactome/R-HSA-2660816.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	177	R-HSA-2660819	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1	yes	reactome/R-HSA-2660819.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	178	R-HSA-2660822	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1	no				GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	179	R-HSA-2666278	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	yes	reactome/R-HSA-2666278.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	180	R-HSA-2220957	NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC	yes	reactome/R-HSA-2220957.md	NOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	181	R-HSA-2220964	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML	yes	reactome/R-HSA-2220964.md	NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	182	R-HSA-2220967	p-NICD1 PEST domain mutants do not bind FBXW7	yes	reactome/R-HSA-2220967.md	p-NICD1 PEST domain mutants do not bind FBXW7	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	183	R-HSA-2220971	CDK8 phosphorylates NICD1 PEST domain mutants	yes	reactome/R-HSA-2220971.md	CDK8 phosphorylates NICD1 PEST domain mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	184	R-HSA-2220982	NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)	yes	reactome/R-HSA-2220982.md	NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	185	R-HSA-2769015	NICD1 PEST domain mutants translocate from cytosol to nucleus	yes	reactome/R-HSA-2769015.md	NICD1 PEST domain mutants translocate from cytosol to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	186	R-HSA-4396392	NOTCH1 PEST domain mutants bind HES1 promoter	yes	reactome/R-HSA-4396392.md	NOTCH1 PEST domain mutants bind HES1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	187	R-HSA-4396393	NOTCH1 PEST domain mutants bind MYC promoter	yes	reactome/R-HSA-4396393.md	NOTCH1 PEST domain mutants bind MYC promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	188	R-HSA-4396401	NOTCH1 PEST domain mutants bind HES5 promoter	yes	reactome/R-HSA-4396401.md	NOTCH1 PEST domain mutants bind HES5 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	189	R-HSA-4396402	NOTCH1 PEST domain mutants bind promoters of HEY genes	yes	reactome/R-HSA-4396402.md	NOTCH1 PEST domain mutants bind promoters of HEY genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	190	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	191	R-HSA-2769015	NICD1 PEST domain mutants translocate from cytosol to nucleus	yes	reactome/R-HSA-2769015.md	NICD1 PEST domain mutants translocate from cytosol to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	192	R-HSA-2220944	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	yes	reactome/R-HSA-2220944.md	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	193	R-HSA-2220976	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	yes	reactome/R-HSA-2220976.md	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	194	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	195	R-HSA-2768993	NOTCH1 PEST domain mutants bind JAG2	yes	reactome/R-HSA-2768993.md	NOTCH1 PEST domain mutants bind JAG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	196	R-HSA-2768999	NOTCH1 PEST domain mutants bind JAG1	yes	reactome/R-HSA-2768999.md	NOTCH1 PEST domain mutants bind JAG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	197	R-HSA-2769000	NOTCH1 PEST domain mutants bind DLL4	yes	reactome/R-HSA-2769000.md	NOTCH1 PEST domain mutants bind DLL4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	198	R-HSA-2769007	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants	yes	reactome/R-HSA-2769007.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	199	R-HSA-2769008	NOTCH1 PEST domain mutants bind DLL1	yes	reactome/R-HSA-2769008.md	NOTCH1 PEST domain mutants bind DLL1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	200	R-HSA-2900743	NOTCH1 HD+PEST domain mutants bind JAG1	yes	reactome/R-HSA-2900743.md	NOTCH1 HD+PEST domain mutants bind JAG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	201	R-HSA-2900747	NOTCH1 HD+PEST domain mutants bind DLL4	yes	reactome/R-HSA-2900747.md	NOTCH1 HD+PEST domain mutants bind DLL4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	202	R-HSA-2900748	NOTCH1 HD+PEST domain mutants bind DLL1	yes	reactome/R-HSA-2900748.md	NOTCH1 HD+PEST domain mutants bind DLL1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	203	R-HSA-2900756	NOTCH1 HD+PEST domain mutants bind JAG2	yes	reactome/R-HSA-2900756.md	NOTCH1 HD+PEST domain mutants bind JAG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	204	R-HSA-2900765	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants	yes	reactome/R-HSA-2900765.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	210	R-HSA-9796071	NFE2L2 dependent NOTCH1 expression	yes	reactome/R-HSA-9796071.md	NFE2L2 dependent NOTCH1 expression	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Endosome membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	215	R-HSA-2220976	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	yes	reactome/R-HSA-2220976.md	NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	216	R-HSA-2900743	NOTCH1 HD+PEST domain mutants bind JAG1	yes	reactome/R-HSA-2900743.md	NOTCH1 HD+PEST domain mutants bind JAG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	217	R-HSA-2900747	NOTCH1 HD+PEST domain mutants bind DLL4	yes	reactome/R-HSA-2900747.md	NOTCH1 HD+PEST domain mutants bind DLL4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	218	R-HSA-2900748	NOTCH1 HD+PEST domain mutants bind DLL1	yes	reactome/R-HSA-2900748.md	NOTCH1 HD+PEST domain mutants bind DLL1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	219	R-HSA-2900756	NOTCH1 HD+PEST domain mutants bind JAG2	yes	reactome/R-HSA-2900756.md	NOTCH1 HD+PEST domain mutants bind JAG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	220	R-HSA-2900765	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants	yes	reactome/R-HSA-2900765.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	255	R-HSA-1912412	NOTCH1 mRNA translation controlled by miRNAs	yes	reactome/R-HSA-1912412.md	NOTCH1 mRNA translation controlled by miRNAs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	256	R-HSA-1912369	NOTCH precursor cleaved to form mature NOTCH	yes	reactome/R-HSA-1912369.md	NOTCH precursor cleaved to form mature NOTCH	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	257	R-HSA-1912382	Mature NOTCH heterodimer traffics to the plasma membrane	yes	reactome/R-HSA-1912382.md	Mature NOTCH heterodimer traffics to the plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	258	R-HSA-5096538	Defective LFNG does not transfer GlcNAc to Pre-NOTCH	yes	reactome/R-HSA-5096538.md	Defective LFNG does not transfer GlcNAc to Pre-NOTCH	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	259	R-HSA-1912382	Mature NOTCH heterodimer traffics to the plasma membrane	yes	reactome/R-HSA-1912382.md	Mature NOTCH heterodimer traffics to the plasma membrane	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	260	R-HSA-1980044	NOTCH1 binds JAG2	yes	reactome/R-HSA-1980044.md	NOTCH1 binds JAG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	261	R-HSA-1980122	DTX binds NOTCH1	yes	reactome/R-HSA-1980122.md	DTX binds NOTCH1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	262	R-HSA-2220944	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	yes	reactome/R-HSA-2220944.md	ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	263	R-HSA-2691211	NOTCH1 HD domain mutants bind DLL4	yes	reactome/R-HSA-2691211.md	NOTCH1 HD domain mutants bind DLL4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	264	R-HSA-2691214	NOTCH1 HD domain mutants bind JAG2	yes	reactome/R-HSA-2691214.md	NOTCH1 HD domain mutants bind JAG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	265	R-HSA-2691219	NOTCH1 HD domain mutants bind DLL1	yes	reactome/R-HSA-2691219.md	NOTCH1 HD domain mutants bind DLL1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	266	R-HSA-2691226	NOTCH1 HD domain mutants bind JAG1	yes	reactome/R-HSA-2691226.md	NOTCH1 HD domain mutants bind JAG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	267	R-HSA-2730752	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	yes	reactome/R-HSA-2730752.md	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	268	R-HSA-2737728	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants	yes	reactome/R-HSA-2737728.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	269	R-HSA-2768993	NOTCH1 PEST domain mutants bind JAG2	yes	reactome/R-HSA-2768993.md	NOTCH1 PEST domain mutants bind JAG2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	270	R-HSA-2768999	NOTCH1 PEST domain mutants bind JAG1	yes	reactome/R-HSA-2768999.md	NOTCH1 PEST domain mutants bind JAG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	271	R-HSA-2769000	NOTCH1 PEST domain mutants bind DLL4	yes	reactome/R-HSA-2769000.md	NOTCH1 PEST domain mutants bind DLL4	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	272	R-HSA-2769007	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants	yes	reactome/R-HSA-2769007.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	273	R-HSA-2769008	NOTCH1 PEST domain mutants bind DLL1	yes	reactome/R-HSA-2769008.md	NOTCH1 PEST domain mutants bind DLL1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	274	R-NUL-2076711	rDll1 binds NOTCH1 in cis	yes	reactome/R-NUL-2076711.md	rDll1 binds NOTCH1 in cis	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	NOTCH1 annotation to extracellular region.
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	275	R-HSA-1912372	Fringe-modified Pre-NOTCH is cleaved by FURIN	yes	reactome/R-HSA-1912372.md	Fringe-modified Pre-NOTCH is cleaved by FURIN	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	276	R-HSA-1912379	Transport of fringe-modified NOTCH to plasma membrane	yes	reactome/R-HSA-1912379.md	Transport of fringe-modified NOTCH to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	277	R-HSA-1912394	NICD1 in complex with RBPJ (CSL) recruits MAML	yes	reactome/R-HSA-1912394.md	NICD1 in complex with RBPJ (CSL) recruits MAML	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	278	R-HSA-212356	Formation of CSL-NICD coactivator complex	yes	reactome/R-HSA-212356.md	Formation of CSL-NICD coactivator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	279	R-HSA-4396371	NOTCH1 Coactivator Complex binds MYC promoter	yes	reactome/R-HSA-4396371.md	NOTCH1 Coactivator Complex binds MYC promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	280	R-HSA-4396379	NOTCH1 Coactivator Complex binds HES5 promoter	yes	reactome/R-HSA-4396379.md	NOTCH1 Coactivator Complex binds HES5 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	281	R-HSA-8878220	RUNX3 binds the NOTCH1 coactivator complex	yes	reactome/R-HSA-8878220.md	RUNX3 binds the NOTCH1 coactivator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	282	R-HSA-8878237	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	yes	reactome/R-HSA-8878237.md	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	283	R-HSA-9017835	NOTCH1 coactivator complex binds NOTCH3 gene	yes	reactome/R-HSA-9017835.md	NOTCH1 coactivator complex binds NOTCH3 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	284	R-HSA-9021451	NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter	yes	reactome/R-HSA-9021451.md	NOTCH1,NOTCH3 coactivator complex binds PLXND1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	285	R-HSA-9762102	NICD1 binds the NFE2L2 promoter	yes	reactome/R-HSA-9762102.md	NICD1 binds the NFE2L2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	286	R-NUL-2064264	NICD1 displaces NCOR co-repressor complex from CSL	yes	reactome/R-NUL-2064264.md	NICD1 displaces NCOR co-repressor complex from CSL	Cercopithecus aethiops	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	287	R-HSA-1912379	Transport of fringe-modified NOTCH to plasma membrane	yes	reactome/R-HSA-1912379.md	Transport of fringe-modified NOTCH to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	288	R-HSA-1912382	Mature NOTCH heterodimer traffics to the plasma membrane	yes	reactome/R-HSA-1912382.md	Mature NOTCH heterodimer traffics to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	289	R-HSA-1980044	NOTCH1 binds JAG2	yes	reactome/R-HSA-1980044.md	NOTCH1 binds JAG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	290	R-HSA-1980122	DTX binds NOTCH1	yes	reactome/R-HSA-1980122.md	DTX binds NOTCH1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	291	R-HSA-2660815	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4	yes	reactome/R-HSA-2660815.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	292	R-HSA-2660816	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2	yes	reactome/R-HSA-2660816.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	293	R-HSA-2660819	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1	yes	reactome/R-HSA-2660819.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	294	R-HSA-2660822	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind JAG1	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	295	R-HSA-2666278	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	yes	reactome/R-HSA-2666278.md	NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	296	R-HSA-2691211	NOTCH1 HD domain mutants bind DLL4	yes	reactome/R-HSA-2691211.md	NOTCH1 HD domain mutants bind DLL4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	297	R-HSA-2691214	NOTCH1 HD domain mutants bind JAG2	yes	reactome/R-HSA-2691214.md	NOTCH1 HD domain mutants bind JAG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	298	R-HSA-2691219	NOTCH1 HD domain mutants bind DLL1	yes	reactome/R-HSA-2691219.md	NOTCH1 HD domain mutants bind DLL1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	299	R-HSA-2691226	NOTCH1 HD domain mutants bind JAG1	yes	reactome/R-HSA-2691226.md	NOTCH1 HD domain mutants bind JAG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	300	R-HSA-2730752	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	yes	reactome/R-HSA-2730752.md	NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	301	R-HSA-2737728	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants	yes	reactome/R-HSA-2737728.md	Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NOTCH1	genes/human/NOTCH1/NOTCH1-ai-review.yaml	NOTCH1	P46531	NCBITaxon:9606	Homo sapiens	302	R-NUL-2076711	rDll1 binds NOTCH1 in cis	yes	reactome/R-NUL-2076711.md	rDll1 binds NOTCH1 in cis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane
human	NPHS2	genes/human/NPHS2/NPHS2-ai-review.yaml	NPHS2	Q9NP85	NCBITaxon:9606	Homo sapiens	13	R-HSA-373734	Nephrin interacts with Podocin	yes	reactome/R-HSA-373734.md	Nephrin interacts with Podocin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for nephrin-podocin interaction at the plasma membrane. This is consistent with the well-established slit diaphragm localization.
human	NPL	genes/human/NPL/NPL-ai-review.yaml	NPL	Q9BXD5	NCBITaxon:9606	Homo sapiens	13	R-HSA-4085217	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate	yes	reactome/R-HSA-4085217.md	NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Core cellular localization. NPL is a soluble cytosolic enzyme (Reactome describes it as a cytosolic tetramer catalyzing Neu5Ac/Neu5Gc cleavage), consistent with the UniProt cytoplasm assignment. This is the more precise CC term for the free sialic acid it acts on. Accept.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	47	R-HSA-9755507	Reactome: KEAP1-NFE2L2 / cytosol localization	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	48	R-HSA-9758088	Reactome: cytosol localization	yes	reactome/R-HSA-9758088.md	UBXN7 binds VCP hexamer:UBF1:NPLOC4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	49	R-HSA-9758090	Reactome: cytosol localization	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	50	R-HSA-9948427	Reactome: cytosol localization	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	59	R-HSA-5654985	Reactome: nucleoplasm localization (signaling-related pathway)	yes	reactome/R-HSA-5654985.md	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasmic localization.
human	NPLOC4	genes/human/NPLOC4/NPLOC4-ai-review.yaml	NPLOC4	Q8TAT6	NCBITaxon:9606	Homo sapiens	60	R-HSA-5654989	Reactome: nucleoplasm localization (signaling-related pathway)	yes	reactome/R-HSA-5654989.md	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasmic localization.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	81	R-HSA-9725009	NPM1-ALK translocates to the nucleus	yes	reactome/R-HSA-9725009.md	NPM1-ALK translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-9725009). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	82	R-HSA-9725023	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	yes	reactome/R-HSA-9725023.md	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-9725023). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	83	R-HSA-9725030	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	yes	reactome/R-HSA-9725030.md	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-9725030). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	84	R-HSA-9851090	NPM1-ALK binds NPM1 and FOXM1	yes	reactome/R-HSA-9851090.md	NPM1-ALK binds NPM1 and FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-9851090). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	85	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9700181). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	86	R-HSA-9700190	ALK mutants bind SHC	yes	reactome/R-HSA-9700190.md	ALK mutants bind SHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9700190). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	87	R-HSA-9700193	ALK mutants phosphorylate SHC1	yes	reactome/R-HSA-9700193.md	ALK mutants phosphorylate SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9700193). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	88	R-HSA-9710914	ALK fusions bind GRB2	yes	reactome/R-HSA-9710914.md	ALK fusions bind GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9710914). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	89	R-HSA-9710917	ALK fusion proteins bind PLCG1	yes	reactome/R-HSA-9710917.md	ALK fusion proteins bind PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9710917). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	90	R-HSA-9712078	ALK mutants bind PI3KR1	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712078). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	91	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712079). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	92	R-HSA-9712081	ALK fusions bind FRS	yes	reactome/R-HSA-9712081.md	ALK fusions bind FRS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712081). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	93	R-HSA-9712082	ALK fusions phosphorylate IRS1	yes	reactome/R-HSA-9712082.md	ALK fusions phosphorylate IRS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712082). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	94	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712083). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	95	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712084). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	96	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712085). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	97	R-HSA-9712086	ALK fusions phosphorylate PLCG1	yes	reactome/R-HSA-9712086.md	ALK fusions phosphorylate PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712086). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	98	R-HSA-9712087	ALK fusions phosphorylate FRS	yes	reactome/R-HSA-9712087.md	ALK fusions phosphorylate FRS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712087). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	99	R-HSA-9712088	ALK fusion proteins bind IRS	yes	reactome/R-HSA-9712088.md	ALK fusion proteins bind IRS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9712088). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	100	R-HSA-9724099	ALK mutants:p-3Y SHC binds GRB2	yes	reactome/R-HSA-9724099.md	ALK mutants:p-3Y SHC binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9724099). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	101	R-HSA-9725009	NPM1-ALK translocates to the nucleus	yes	reactome/R-HSA-9725009.md	NPM1-ALK translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9725009). NPM1 shuttles to the cytoplasm/cytosol as part of its normal function in ribosome export and protein transport.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	102	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9850958). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	107	R-HSA-4086088	SUMOylation of NPM1 with SUMO1	yes	reactome/R-HSA-4086088.md	SUMOylation of NPM1 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-4086088). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	108	R-HSA-4086059	SUMOylation of NPM1 with SUMO2,3	yes	reactome/R-HSA-4086059.md	SUMOylation of NPM1 with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-4086059). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	110	R-HSA-9700131	ALK mutants bind type I TKIs	yes	reactome/R-HSA-9700131.md	ALK mutants bind type I TKIs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9700131). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	111	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9700179). This annotation relates to the NPM1-ALK fusion oncoprotein signaling pathway in anaplastic large cell lymphoma. The cytosol localization reflects the ALK fusion context, not normal NPM1 function.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	115	R-HSA-9727886	SARS-CoV-1 SUMO-p-N binds to NPM1	yes	reactome/R-HSA-9727886.md	SARS-CoV-1 SUMO-p-N binds to NPM1	Homo sapiens	GO:0001652	granular component	TAS	located_in	CC	false		ACCEPT	TAS annotation for granular component from Reactome (SARS-CoV-1 N protein binds NPM1). NPM1 localizes to the GC of the nucleolus. This Reactome entry is about viral interaction but the localization is correct.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	116	R-HSA-180728	Association of Ran-GTP with importin-beta	yes	reactome/R-HSA-180728.md	Association of Ran-GTP with importin-beta	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-180728). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	117	R-HSA-180736	Disassembly of the Rev-importin beta-B23:Ran-GTP complex	yes	reactome/R-HSA-180736.md	Disassembly of the Rev-importin beta-B23:Ran-GTP complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-180736). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	118	R-HSA-606287	RSF complex binds the centromere	yes	reactome/R-HSA-606287.md	RSF complex binds the centromere	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-606287). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	119	R-HSA-606289	New CENPA-containing nucleosomes are deposited at the centromere	yes	reactome/R-HSA-606289.md	New CENPA-containing nucleosomes are deposited at the centromere	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-606289). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	120	R-HSA-606326	HJURP:CENPA complex localizes to the centromere	yes	reactome/R-HSA-606326.md	HJURP:CENPA complex localizes to the centromere	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-606326). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	121	R-HSA-8869542	TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter	yes	reactome/R-HSA-8869542.md	TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-8869542). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	122	R-HSA-8869543	TFPA2A homodimer and NPM1 bind the NOP2 gene promoter	yes	reactome/R-HSA-8869543.md	TFPA2A homodimer and NPM1 bind the NOP2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-8869543). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	123	R-HSA-8869549	TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter	yes	reactome/R-HSA-8869549.md	TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-8869549). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	124	R-HSA-8869568	NPM1 binds TFAP2A homodimer	yes	reactome/R-HSA-8869568.md	NPM1 binds TFAP2A homodimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome (Reactome:R-HSA-8869568). NPM1 nucleoplasm localization is well-established. Redundant with IBA and multiple IDA annotations.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	137	R-HSA-6801675	PLK2 phosphorylates NPM1	yes	reactome/R-HSA-6801675.md	PLK2 phosphorylates NPM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (Reactome:R-HSA-6801675). NPM1 shuttles to the cytoplasm/cytosol as part of its normal function in ribosome export and protein transport.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	154	R-HSA-180725	Rev associates with B23	yes	reactome/R-HSA-180725.md	Rev associates with B23	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (Reactome:R-HSA-180725). NPM1 shuttles to the cytoplasm/cytosol as part of its normal function in ribosome export and protein transport.
human	NPM1	genes/human/NPM1/NPM1-ai-review.yaml	NPM1	P06748	NCBITaxon:9606	Homo sapiens	155	R-HSA-9835328	NPM binds PKR	yes	reactome/R-HSA-9835328.md	NPM binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (Reactome:R-HSA-9835328). NPM1 shuttles to the cytoplasm/cytosol as part of its normal function in ribosome export and protein transport.
human	NQO2	genes/human/NQO2/NQO2-ai-review.yaml	NQO2	P16083	NCBITaxon:9606	Homo sapiens	24	R-HSA-8936519	NQO2:FAD dimer reduces quinones to hydroquinones	yes	reactome/R-HSA-8936519.md	NQO2:FAD dimer reduces quinones to hydroquinones	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable-author-statement cytosol annotation from Reactome (NQO2:FAD dimer reduces quinones to hydroquinones).
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	28	R-HSA-5673001	RAF/MAP kinase cascade	yes	reactome/R-HSA-5673001.md	RAF/MAP kinase cascade	Homo sapiens	GO:0000165	MAPK cascade	TAS	involved_in	BP	false		ACCEPT	Reactome places NRAS in the RAF/MAP kinase cascade, consistent with its core role as an upstream activator of RAF-MEK-ERK signaling.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	36	R-HSA-9649736	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		ACCEPT	Reactome attributes GTPase activity to NRAS, its canonical catalytic molecular function.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	37	R-HSA-9647980	mature RAS proteins translocate to plasma membrane	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome RAS-processing/localization events place NRAS at the Golgi apparatus membrane, a bona-fide localization in its PM-Golgi shuttling cycle.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	38	R-HSA-9647982	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome RAS-processing/localization events place NRAS at the Golgi apparatus membrane, a bona-fide localization in its PM-Golgi shuttling cycle.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	39	R-HSA-9647977	ICMT methylates S-Farn RAS proteins	yes	reactome/R-HSA-9647977.md	ICMT methylates S-Farn RAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	40	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	41	R-HSA-9647982	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	yes	reactome/R-HSA-9647982.md	S-farn Me-HRAS, -NRAS and -KRAS4A are palmitoylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	42	R-HSA-9647999	RCE1 cleaves S-Farn proRAS proteins	yes	reactome/R-HSA-9647999.md	RCE1 cleaves S-Farn proRAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome RAS-processing events localize NRAS to the endoplasmic reticulum membrane, where post-translational CAAX processing (RCE1/ICMT) of newly farnesylated Ras occurs en route to the Golgi and plasma membrane.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	43	R-HSA-1168636	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP	yes	reactome/R-HSA-1168636.md	p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	44	R-HSA-1225951	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	45	R-HSA-1225957	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	46	R-HSA-1250383	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	yes	reactome/R-HSA-1250383.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	47	R-HSA-1306972	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306972.md	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	48	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	49	R-HSA-170986	Ral-GDS binds to Ras-GTP	yes	reactome/R-HSA-170986.md	Ral-GDS binds to Ras-GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	50	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	51	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	52	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	53	R-HSA-210977	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	54	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	55	R-HSA-2424477	SOS mediated nucleotide exchange of RAS (SHC)	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	56	R-HSA-392054	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	57	R-HSA-5218845	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	58	R-HSA-5621573	CD209 activate GTPase RAS	yes	reactome/R-HSA-5621573.md	CD209 activate GTPase RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	59	R-HSA-5624486	SFKs phosphorylates RAF1 on Y340,Y341	yes	reactome/R-HSA-5624486.md	SFKs phosphorylates RAF1 on Y340,Y341	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	60	R-HSA-5624492	PAK phosphorylates p21 RAF1 on S338	yes	reactome/R-HSA-5624492.md	PAK phosphorylates p21 RAF1 on S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	61	R-HSA-5624494	RAF1 binds p21 RAS:GTP	yes	reactome/R-HSA-5624494.md	RAF1 binds p21 RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	62	R-HSA-5637806	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	63	R-HSA-5637808	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	64	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	65	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	66	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	67	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	68	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	69	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	70	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	71	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	72	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	73	R-HSA-5655277	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	74	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	75	R-HSA-5655347	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655347.md	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	76	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	77	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	78	R-HSA-5672950	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	yes	reactome/R-HSA-5672950.md	"""Activator"" RAF:YWHAB dimer binds RAS:GTP"	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	79	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	80	R-HSA-5672966	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	yes	reactome/R-HSA-5672966.md	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	81	R-HSA-5672969	Phosphorylation of RAF	yes	reactome/R-HSA-5672969.md	Phosphorylation of RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	82	R-HSA-5672972	MAP2Ks and MAPKs bind to the activated RAF complex	yes	reactome/R-HSA-5672972.md	MAP2Ks and MAPKs bind to the activated RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	83	R-HSA-5672973	MAP2Ks phosphorylate MAPKs	yes	reactome/R-HSA-5672973.md	MAP2Ks phosphorylate MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	84	R-HSA-5672978	RAF phosphorylates MAP2K dimer	yes	reactome/R-HSA-5672978.md	RAF phosphorylates MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	85	R-HSA-5672980	Dissociation of RAS:RAF complex	yes	reactome/R-HSA-5672980.md	Dissociation of RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	86	R-HSA-5674018	BRAP binds RAS:GTP	yes	reactome/R-HSA-5674018.md	BRAP binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	87	R-HSA-5674022	BRAP autoubiquitinates	yes	reactome/R-HSA-5674022.md	BRAP autoubiquitinates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	88	R-HSA-5675417	PEBP1 binds activated RAF1	yes	reactome/R-HSA-5675417.md	PEBP1 binds activated RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	89	R-HSA-5675431	PP2A dephosphorylates RAF1	yes	reactome/R-HSA-5675431.md	PP2A dephosphorylates RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	90	R-HSA-5675433	PP5 dephosphorylates RAF1 S338	yes	reactome/R-HSA-5675433.md	PP5 dephosphorylates RAF1 S338	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	91	R-HSA-6802837	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	yes	reactome/R-HSA-6802837.md	Loss-of-function NF1 variants don't stimulate RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	92	R-HSA-8851827	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	yes	reactome/R-HSA-8851827.md	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	93	R-HSA-8851877	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	yes	reactome/R-HSA-8851877.md	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	94	R-HSA-8851899	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	yes	reactome/R-HSA-8851899.md	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	95	R-HSA-8941613	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941613.md	Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	96	R-HSA-8941618	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941618.md	Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	97	R-HSA-8941623	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941623.md	Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	98	R-HSA-8941628	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange	yes	reactome/R-HSA-8941628.md	Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	99	R-HSA-8981353	RASA1 stimulates RAS GTPase activity	yes	reactome/R-HSA-8981353.md	RASA1 stimulates RAS GTPase activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	100	R-HSA-8981355	RASA1 binds RAS:GTP	yes	reactome/R-HSA-8981355.md	RASA1 binds RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	101	R-HSA-9607304	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	102	R-HSA-9632906	PRKCZ recruits RAS in response to estrogen stimulation	yes	reactome/R-HSA-9632906.md	PRKCZ recruits RAS in response to estrogen stimulation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	103	R-HSA-9632918	PRKCZ stimulates RAS nucleotide exchange in response to estrogen	yes	reactome/R-HSA-9632918.md	PRKCZ stimulates RAS nucleotide exchange in response to estrogen	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	104	R-HSA-9634418	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	yes	reactome/R-HSA-9634418.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	105	R-HSA-9647980	mature RAS proteins translocate to plasma membrane	yes	reactome/R-HSA-9647980.md	mature RAS proteins translocate to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	106	R-HSA-9647994	RAS proteins are depalmitoylated	yes	reactome/R-HSA-9647994.md	RAS proteins are depalmitoylated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	107	R-HSA-9649733	mature p21 RAS binds GDP	yes	reactome/R-HSA-9649733.md	mature p21 RAS binds GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	108	R-HSA-9649735	Intrinsic nucleotide exchange on RAS	yes	reactome/R-HSA-9649735.md	Intrinsic nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	109	R-HSA-9649736	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	yes	reactome/R-HSA-9649736.md	RAS intrinsic GTPase activity hydrolyzes GTP to GDP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	110	R-HSA-9653108	Raf dimer inhibitors bind RAF heterodimers	yes	reactome/R-HSA-9653108.md	Raf dimer inhibitors bind RAF heterodimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	111	R-HSA-9656209	Dissociation of RAS:RAF1 mutant complex	yes	reactome/R-HSA-9656209.md	Dissociation of RAS:RAF1 mutant complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	112	R-HSA-9656211	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	yes	reactome/R-HSA-9656211.md	MAP2Ks and MAPKs bind to the activated mutant RAF1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	113	R-HSA-9656212	Phosphorylation of RAF1 mutants	yes	reactome/R-HSA-9656212.md	Phosphorylation of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	114	R-HSA-9656213	RAF1 mutants show enhanced heterodimerization with BRAF	yes	reactome/R-HSA-9656213.md	RAF1 mutants show enhanced heterodimerization with BRAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	115	R-HSA-9656214	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	yes	reactome/R-HSA-9656214.md	MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	116	R-HSA-9656215	RAF1 mutant complexes phosphorylate MAP2K dimer	yes	reactome/R-HSA-9656215.md	RAF1 mutant complexes phosphorylate MAP2K dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	117	R-HSA-9657599	Dual mechanism MAP2K inhibitors bind MAP2Ks	yes	reactome/R-HSA-9657599.md	Dual mechanism MAP2K inhibitors bind MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	118	R-HSA-9657603	Dual mechanism MAPK inhibitors bind MAPKs	yes	reactome/R-HSA-9657603.md	Dual mechanism MAPK inhibitors bind MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	119	R-HSA-9657606	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	yes	reactome/R-HSA-9657606.md	Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	120	R-HSA-9657608	Single mechanism MAPK inhibitors bind phosphorylated MAPK	yes	reactome/R-HSA-9657608.md	Single mechanism MAPK inhibitors bind phosphorylated MAPK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	121	R-HSA-9658253	RAS:GTP binds PI3K	yes	reactome/R-HSA-9658253.md	RAS:GTP binds PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	122	R-HSA-9664991	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	123	R-HSA-9665009	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	124	R-HSA-9665404	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	125	R-HSA-9665408	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	126	R-HSA-9665700	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	127	R-HSA-9665707	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	128	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	129	R-HSA-9672163	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672163.md	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	130	R-HSA-9672170	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	131	R-HSA-9695853	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	132	R-HSA-9703441	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	133	R-HSA-9647978	pro-RAS proteins are farnesylated	yes	reactome/R-HSA-9647978.md	pro-RAS proteins are farnesylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localizes newly synthesized, pre-processed (farnesylated but not yet membrane-anchored) NRAS to the cytosol during RAS processing.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	134	R-HSA-6802834	RAS GTPase mutants don't hydrolyze GTP	yes	reactome/R-HSA-6802834.md	RAS GTPase mutants don't hydrolyze GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	135	R-HSA-6802908	RAS mutants bind inactive RAF	yes	reactome/R-HSA-6802908.md	RAS mutants bind inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	136	R-HSA-6802918	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	yes	reactome/R-HSA-6802918.md	Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	137	R-HSA-6802922	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	yes	reactome/R-HSA-6802922.md	Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	138	R-HSA-6802924	RAF is phosphorylated downstream of oncogenic RAS	yes	reactome/R-HSA-6802924.md	RAF is phosphorylated downstream of oncogenic RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	139	R-HSA-6802925	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802925.md	Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	140	R-HSA-6802926	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802926.md	Mutant RAS:p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	141	R-HSA-6802937	Inactive BRAF mutants bind mutant RAS:GTP	yes	reactome/R-HSA-6802937.md	Inactive BRAF mutants bind mutant RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	142	R-HSA-6802941	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	yes	reactome/R-HSA-6802941.md	RAF is paradoxically phosphorylated downstream of kinase-inactive RAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	143	R-HSA-6802942	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802942.md	RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	144	R-HSA-6802943	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802943.md	RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	145	R-HSA-6803233	Dissociation of oncogenic RAS:RAF complex	yes	reactome/R-HSA-6803233.md	Dissociation of oncogenic RAS:RAF complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	146	R-HSA-6803234	Dissociation of paradoxically activated RAS:BRAF complexes	yes	reactome/R-HSA-6803234.md	Dissociation of paradoxically activated RAS:BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	147	R-HSA-6803240	Homo- or heterodimerization of RAF downstream of mutant RAS	yes	reactome/R-HSA-6803240.md	Homo- or heterodimerization of RAF downstream of mutant RAS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	148	R-HSA-8936731	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	yes	reactome/R-HSA-8936731.md	Inactive BRAF mutants:mutant RAS:GTP bind RAF1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	149	R-HSA-9651280	RAS GAP mutants aren't stimulated by GAPs	yes	reactome/R-HSA-9651280.md	RAS GAP mutants aren't stimulated by GAPs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	154	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	This Reactome annotation (neutrophil degranulation pathway) places NRAS at the tertiary granule membrane in neutrophils. It reflects pathway-level granule-proteome membership rather than a core functional localization.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	157	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	158	R-HSA-6802914	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802914.md	RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	159	R-HSA-6802915	Moderate kinase activity BRAF mutants bind RAS:GTP	yes	reactome/R-HSA-6802915.md	Moderate kinase activity BRAF mutants bind RAS:GTP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	160	R-HSA-6802916	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802916.md	RAF is phosphorylated downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	161	R-HSA-6802919	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	yes	reactome/R-HSA-6802919.md	RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	162	R-HSA-6802921	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	yes	reactome/R-HSA-6802921.md	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	163	R-HSA-6803230	Dissociation of moderate activity BRAF complexes	yes	reactome/R-HSA-6803230.md	Dissociation of moderate activity BRAF complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NRAS	genes/human/NRAS/NRAS-ai-review.yaml	NRAS	P01111	NCBITaxon:9606	Homo sapiens	164	R-HSA-8936676	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	yes	reactome/R-HSA-8936676.md	Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome maps NRAS as a participant located at the plasma membrane across numerous RTK-to-RAS activation and RAF/MAPK signaling reactions. Plasma membrane is the principal, well-supported localization for NRAS.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	13	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in cholesterol biosynthesis (Bloch pathway via desmosterol). NSDHL performs the C4-decarboxylation steps that convert 4,4-dimethyl/4-monomethyl sterol intermediates toward zymosterol and onward to cholesterol.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	14	R-HSA-6807062	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	yes	reactome/R-HSA-6807062.md	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in cholesterol biosynthesis (Kandutsch-Russell pathway via lathosterol/zymostenol). NSDHL's C4-demethylation reactions are shared between the Bloch and Kandutsch-Russell routes.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	16	R-HSA-194642	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one	yes	reactome/R-HSA-194642.md	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one	Homo sapiens	GO:0000252	3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the C4-decarboxylase activity in the reaction converting 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol to 4-methylcholesta-8(9),24-dien-3-one + CO2 + NADH, catalyzed by NSDHL in the ER.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	17	R-HSA-194718	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)	yes	reactome/R-HSA-194718.md	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)	Homo sapiens	GO:0000252	3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the C4-decarboxylase activity in the reaction converting 4-carboxycholesta-8(9),24-dien-3beta-ol to zymosterone + CO2 + NADH, catalyzed by NSDHL in the ER.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	28	R-HSA-194642	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one	yes	reactome/R-HSA-194642.md	4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the NSDHL-catalyzed decarboxylation reaction to the ER membrane. Consistent with EXP/IC/IDA evidence for ER-membrane residence.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	29	R-HSA-194718	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)	yes	reactome/R-HSA-194718.md	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing another NSDHL decarboxylation reaction (to zymosterone) to the ER membrane. Duplicate of the correct ER-membrane localization.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	30	R-HSA-9945787	NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one	yes	reactome/R-HSA-9945787.md	NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the NSDHL reaction converting 4alpha-carboxy-5alpha-cholest-8-ene-3beta-ol to 5alpha-cholest-8-en-3-one to the ER membrane.
human	NSDHL	genes/human/NSDHL/NSDHL-ai-review.yaml	NSDHL	Q15738	NCBITaxon:9606	Homo sapiens	31	R-HSA-9945822	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol	yes	reactome/R-HSA-9945822.md	NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing the NSDHL reaction converting 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol to the ER membrane.
human	NSUN2	genes/human/NSUN2/NSUN2-ai-review.yaml	NSUN2	Q08J23	NCBITaxon:9606	Homo sapiens	28	R-HSA-6785438	NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)	yes	reactome/R-HSA-6785438.md	NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)	Homo sapiens	GO:0006400	tRNA modification	TAS	involved_in	BP	false		ACCEPT	Reactome statement that NSUN2 methylates C40 and C48-C50 of tRNA-Gly(GCC).
human	NSUN2	genes/human/NSUN2/NSUN2-ai-review.yaml	NSUN2	Q08J23	NCBITaxon:9606	Homo sapiens	42	R-HSA-6785438	NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)	yes	reactome/R-HSA-6785438.md	NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic location asserted by the Reactome tRNA modification reaction.
human	NT5C1A	genes/human/NT5C1A/NT5C1A-ai-review.yaml	NT5C1A	Q9BXI3	NCBITaxon:9606	Homo sapiens	33	R-HSA-109380	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)	yes	reactome/R-HSA-109380.md	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction (pyrimidine/dCMP dephosphorylation by NT5C1A) localizes the enzyme to the cytosol. Consistent with all other localization evidence.
human	NT5C1A	genes/human/NT5C1A/NT5C1A-ai-review.yaml	NT5C1A	Q9BXI3	NCBITaxon:9606	Homo sapiens	34	R-HSA-109387	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]	yes	reactome/R-HSA-109387.md	(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction ((deoxy)purine nucleoside monophosphate dephosphorylation by NT5C1A) in the cytosol. Consistent with the established cytosolic localization.
human	NT5C2	genes/human/NT5C2/NT5C2-ai-review.yaml	NT5C2	P49902	NCBITaxon:9606	Homo sapiens	48	R-HSA-2162066	carbovir + IMP => carbovir monophosphate + inosine	yes	reactome/R-HSA-2162066.md	carbovir + IMP => carbovir monophosphate + inosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement placing cN-II in the cytosol (in the context of carbovir/abacavir metabolism). Correct core location; accept.
human	NT5C2	genes/human/NT5C2/NT5C2-ai-review.yaml	NT5C2	P49902	NCBITaxon:9606	Homo sapiens	49	R-HSA-74248	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)	yes	reactome/R-HSA-74248.md	(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (in the (d)GMP/(d)IMP dephosphorylation reaction). Correct core location; accept.
human	NT5C2	genes/human/NT5C2/NT5C2-ai-review.yaml	NT5C2	P49902	NCBITaxon:9606	Homo sapiens	50	R-HSA-9754916	NT5C2 tetramer phosphorylates RBV	yes	reactome/R-HSA-9754916.md	NT5C2 tetramer phosphorylates RBV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (NT5C2 tetramer phosphorylates ribavirin). Correct core location; accept.
human	NT5C2	genes/human/NT5C2/NT5C2-ai-review.yaml	NT5C2	P49902	NCBITaxon:9606	Homo sapiens	51	R-HSA-9755078	NT5C2 tetramer dephosphorylates RBV-MP	yes	reactome/R-HSA-9755078.md	NT5C2 tetramer dephosphorylates RBV-MP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol annotation (NT5C2 tetramer dephosphorylates ribavirin-MP). Correct core location; accept.
human	NT5C3A	genes/human/NT5C3A/NT5C3A-ai-review.yaml	NT5C3A	Q9H0P0	NCBITaxon:9606	Homo sapiens	20	R-HSA-109449	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)	yes	reactome/R-HSA-109449.md	(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author-statement placing the enzyme in the cytosol, within the ""(d)CMP, TMP, or (d)UMP + H2O => ... + orthophosphate"" reaction of pyrimidine catabolism. Correct core location. Accept."
human	NT5E	genes/human/NT5E/NT5E-ai-review.yaml	NT5E	P21589	NCBITaxon:9606	Homo sapiens	40	R-HSA-109278	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP	yes	reactome/R-HSA-109278.md	NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (NT5E:Zn2+ hydrolyses AMP,dAMP,GMP,IMP) placing the enzyme at the plasma membrane. Consistent with the GPI-anchored ectoenzyme. Accept.
human	NT5E	genes/human/NT5E/NT5E-ai-review.yaml	NT5E	P21589	NCBITaxon:9606	Homo sapiens	41	R-HSA-109291	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]	yes	reactome/R-HSA-109291.md	CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (CMP/TMP/UMP hydrolysis by NT5E) placing the enzyme at the plasma membrane. Accept as core localization.
human	NT5E	genes/human/NT5E/NT5E-ai-review.yaml	NT5E	P21589	NCBITaxon:9606	Homo sapiens	42	R-HSA-8940070	NT5E:Zn2+ hydrolyses NAD+	yes	reactome/R-HSA-8940070.md	NT5E:Zn2+ hydrolyses NAD+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (NT5E:Zn2+ hydrolyses NAD+) placing the enzyme at the plasma membrane. Accept as core localization.
human	NT5E	genes/human/NT5E/NT5E-ai-review.yaml	NT5E	P21589	NCBITaxon:9606	Homo sapiens	43	R-HSA-8940074	NT5E:Zn2+ hydrolyses NMN	yes	reactome/R-HSA-8940074.md	NT5E:Zn2+ hydrolyses NMN	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome (NT5E:Zn2+ hydrolyses NMN) placing the enzyme at the plasma membrane. Accept as core localization.
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	24	R-HSA-373707	Netrin-1 induced DCC clustering	yes	reactome/R-HSA-373707.md	Netrin-1 induced DCC clustering	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Netrin-1 induced DCC clustering"". NTN1 functions extracellularly where it binds DCC receptors."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	25	R-HSA-373711	DCC interaction with Netrin-1	yes	reactome/R-HSA-373711.md	DCC interaction with Netrin-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""DCC interaction with Netrin-1"". NTN1 is secreted and functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	26	R-HSA-373713	DCC heterodimerizes with UNC-5:Netrin-1	yes	reactome/R-HSA-373713.md	DCC heterodimerizes with UNC-5:Netrin-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""DCC heterodimerizes with UNC-5:Netrin-1"". NTN1 functions extracellularly where it binds receptors."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	27	R-HSA-373716	DCC interacting NCK-1	yes	reactome/R-HSA-373716.md	DCC interacting NCK-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""DCC interacting NCK-1"". NTN1 functions extracellularly as a secreted guidance cue."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	28	R-HSA-373751	UNC-5 binds Netrin-1	yes	reactome/R-HSA-373751.md	UNC-5 binds Netrin-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""UNC-5 binds Netrin-1"". NTN1 binds UNC5 receptors extracellularly for repulsive guidance."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	29	R-HSA-374665	DCC interaction with SIAH1	yes	reactome/R-HSA-374665.md	DCC interaction with SIAH1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""DCC interaction with SIAH1"". NTN1 functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	30	R-HSA-374667	DCC interaction with SIAH2	yes	reactome/R-HSA-374667.md	DCC interaction with SIAH2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""DCC interaction with SIAH2"". NTN1 functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	31	R-HSA-374701	Phosphorylation of DCC by Fyn	yes	reactome/R-HSA-374701.md	Phosphorylation of DCC by Fyn	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Phosphorylation of DCC by Fyn"". NTN1 functions extracellularly to trigger this signaling."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	32	R-HSA-418850	Activation of Cdc42	yes	reactome/R-HSA-418850.md	Activation of Cdc42	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Activation of Cdc42"". NTN1 functions extracellularly to trigger downstream Cdc42 signaling."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	33	R-HSA-418856	Activation of Rac1	yes	reactome/R-HSA-418856.md	Activation of Rac1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Activation of Rac1"". NTN1 functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	34	R-HSA-418858	RhoGTPase GEF's recruited to DCC	yes	reactome/R-HSA-418858.md	RhoGTPase GEF's recruited to DCC	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""RhoGTPase GEF's recruited to DCC"". NTN1 functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	35	R-HSA-418868	Recruitment of Src and Fyn to DCC:FADK1	yes	reactome/R-HSA-418868.md	Recruitment of Src and Fyn to DCC:FADK1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Recruitment of Src and Fyn to DCC:FADK1"". NTN1 functions extracellularly."
human	NTN1	genes/human/NTN1/NTN1-ai-review.yaml	NTN1	O95631	NCBITaxon:9606	Homo sapiens	36	R-HSA-418874	Recruitment and activation of N-WASP by Cdc42	yes	reactome/R-HSA-418874.md	Recruitment and activation of N-WASP by Cdc42	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Correct localization annotation from Reactome pathway ""Recruitment and activation of N-WASP by Cdc42"". NTN1 functions extracellularly."
human	NUBPL	genes/human/NUBPL/NUBPL-ai-review.yaml	NUBPL	Q8TB37	NCBITaxon:9606	Homo sapiens	15	R-HSA-5690023	NUBPL binds 4Fe-4S	yes	reactome/R-HSA-5690023.md	NUBPL binds 4Fe-4S	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing NUBPL in the mitochondrial matrix, in the reaction where NUBPL binds the [4Fe-4S] cluster. Consistent with a matrix-soluble assembly factor.
human	NUBPL	genes/human/NUBPL/NUBPL-ai-review.yaml	NUBPL	Q8TB37	NCBITaxon:9606	Homo sapiens	16	R-HSA-6788523	NUBPL transfers 4Fe-4S to Complex I subunits	yes	reactome/R-HSA-6788523.md	NUBPL transfers 4Fe-4S to Complex I subunits	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS matrix localization from the reaction ""NUBPL transfers 4Fe-4S to Complex I subunits."" Duplicate of the same matrix localization."
human	NUBPL	genes/human/NUBPL/NUBPL-ai-review.yaml	NUBPL	Q8TB37	NCBITaxon:9606	Homo sapiens	17	R-HSA-6788556	NUBPL transfers 4Fe-4S to NDUFV1, V2	yes	reactome/R-HSA-6788556.md	NUBPL transfers 4Fe-4S to NDUFV1, V2	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS matrix localization from the reaction ""NUBPL transfers 4Fe-4S to NDUFV1, V2."" Duplicate of the same matrix localization."
human	NUS1	genes/human/NUS1/NUS1-ai-review.yaml	NUS1	Q96E22	NCBITaxon:9606	Homo sapiens	29	R-HSA-4419978	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP	yes	reactome/R-HSA-4419978.md	DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation locating the DHDDS:NUS1 elongation reaction at the ER membrane. Correct core location.
human	NUS1	genes/human/NUS1/NUS1-ai-review.yaml	NUS1	Q96E22	NCBITaxon:9606	Homo sapiens	30	R-HSA-4755545	Defective DHDDS does not elongate E,E-FPP	yes	reactome/R-HSA-4755545.md	Defective DHDDS does not elongate E,E-FPP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (defective-DHDDS reaction context) locating the enzyme at the ER membrane. Correct core location.
human	OAT	genes/human/OAT/OAT-ai-review.yaml	OAT	P04181	NCBITaxon:9606	Homo sapiens	17	R-HSA-70654	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]	yes	reactome/R-HSA-70654.md	ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of mitochondrial-matrix localization (forward reaction: ornithine + alpha-ketoglutarate -> glutamate + glutamate gamma-semialdehyde). Consistent with the experimental location. Accept.
human	OAT	genes/human/OAT/OAT-ai-review.yaml	OAT	P04181	NCBITaxon:9606	Homo sapiens	18	R-HSA-70666	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]	yes	reactome/R-HSA-70666.md	glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome traceable assignment of mitochondrial-matrix localization (reverse reaction: glutamate + glutamate gamma-semialdehyde -> ornithine + alpha-ketoglutarate). Consistent with the experimental location. Accept.
human	OAZ1	genes/human/OAZ1/OAZ1-ai-review.yaml	OAZ1	P54368	NCBITaxon:9606	Homo sapiens	10	R-HSA-350562	Regulation of ornithine decarboxylase (ODC)	yes	reactome/R-HSA-350562.md	Regulation of ornithine decarboxylase (ODC)	Homo sapiens	GO:0006596	polyamine biosynthetic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome pathway annotation placing antizyme within polyamine metabolism. OAZ1 participates in polyamine metabolism, but as a NEGATIVE regulator of polyamine synthesis the 'biosynthetic process' framing with an 'involved_in' qualifier is misleading. The antizyme role is better captured by the polyamine-homeostasis and negative-regulation terms. Over-annotated.
human	OAZ1	genes/human/OAZ1/OAZ1-ai-review.yaml	OAZ1	P54368	NCBITaxon:9606	Homo sapiens	12	R-HSA-350567	Antizyme OAZ binds to Ornithine decarboxylase	yes	reactome/R-HSA-350567.md	Antizyme OAZ binds to Ornithine decarboxylase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. The cytosol is the principal site where antizyme binds ODC monomers and delivers them to the 26S proteasome. Accept as the core location.
human	OAZ1	genes/human/OAZ1/OAZ1-ai-review.yaml	OAZ1	P54368	NCBITaxon:9606	Homo sapiens	13	R-HSA-353125	26S proteosome degrades ODC holoenzyme complex	yes	reactome/R-HSA-353125.md	26S proteosome degrades ODC holoenzyme complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol localization (different Reactome reaction). Same well-supported core location as the annotation above. Accept.
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	18	R-HSA-351202	Metabolism of polyamines	yes	reactome/R-HSA-351202.md	Metabolism of polyamines	Homo sapiens	GO:0006595	polyamine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome TAS annotation to the broad polyamine metabolic process (""Metabolism of polyamines""). Correct but general; kept as a non-core grouping term, subsumed by the specific putrescine/polyamine biosynthetic process annotations."
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	21	R-HSA-350567	Antizyme OAZ binds to Ornithine decarboxylase	yes	reactome/R-HSA-350567.md	Antizyme OAZ binds to Ornithine decarboxylase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (antizyme-binding reaction context). ODC is cytosolic; correct core localization.
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	22	R-HSA-350578	NQO1 interaction with ODC	yes	reactome/R-HSA-350578.md	NQO1 interaction with ODC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (NQO1-ODC interaction context). Redundant with other cytosol annotations; correct core localization.
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	23	R-HSA-353125	26S proteosome degrades ODC holoenzyme complex	yes	reactome/R-HSA-353125.md	26S proteosome degrades ODC holoenzyme complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (proteasomal degradation-of-ODC context). Redundant with other cytosol annotations; correct.
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	24	R-HSA-70692	ornithine => putrescine + CO2	yes	reactome/R-HSA-70692.md	ornithine => putrescine + CO2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization tied directly to the ornithine => putrescine + CO2 reaction. Correct core localization for the enzymatic activity.
human	ODC1	genes/human/ODC1/ODC1-ai-review.yaml	ODC1	P11926	NCBITaxon:9606	Homo sapiens	25	R-HSA-9955574	ODC dimerizes	yes	reactome/R-HSA-9955574.md	ODC dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (ODC dimerization context). Consistent with cytosolic dimeric holoenzyme; correct.
human	OLA1	genes/human/OLA1/OLA1-ai-review.yaml	OLA1	Q9NTK5	NCBITaxon:9606	Homo sapiens	18	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		REMOVE	Reactome pathway annotation places OLA1 in platelet alpha granules released extracellularly. Supported by exosome proteomics.
human	OLA1	genes/human/OLA1/OLA1-ai-review.yaml	OLA1	Q9NTK5	NCBITaxon:9606	Homo sapiens	19	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		REMOVE	Reactome annotation correctly places OLA1 in platelet alpha granule lumen for secretion.
human	OMA1	genes/human/OMA1/OMA1-ai-review.yaml	OMA1	Q96E52	NCBITaxon:9606	Homo sapiens	16	R-HSA-8867344	OMA1 hydrolyses OPA1	yes	reactome/R-HSA-8867344.md	OMA1 hydrolyses OPA1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	OMA1 is an inner-mitochondrial-membrane protease; the characterized human protein has the catalytic membrane-protease architecture.
human	OMA1	genes/human/OMA1/OMA1-ai-review.yaml	OMA1	Q96E52	NCBITaxon:9606	Homo sapiens	17	R-HSA-9840408	OMA1 cleaves DELE1	yes	reactome/R-HSA-9840408.md	OMA1 cleaves DELE1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	OMA1 is an inner-mitochondrial-membrane protease; the characterized human protein has the catalytic membrane-protease architecture.
human	OMA1	genes/human/OMA1/OMA1-ai-review.yaml	OMA1	Q96E52	NCBITaxon:9606	Homo sapiens	18	R-HSA-9840564	OMA1 hydrolyzes YME1L1	yes	reactome/R-HSA-9840564.md	OMA1 hydrolyzes YME1L1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	OMA1 is an inner-mitochondrial-membrane protease; the characterized human protein has the catalytic membrane-protease architecture.
human	OPLAH	genes/human/OPLAH/OPLAH-ai-review.yaml	OPLAH	O14841	NCBITaxon:9606	Homo sapiens	11	R-HSA-5603208	Defective OPLAH does not hydrolyse OPRO	yes	reactome/R-HSA-5603208.md	Defective OPLAH does not hydrolyse OPRO	Homo sapiens	GO:0017168	5-oxoprolinase (ATP-hydrolyzing) activity	TAS	enables	MF	false		ACCEPT	"Reactome traceable-author-statement for the 5-oxoprolinase activity (from the reaction ""Defective OPLAH does not hydrolyse OPRO""). Correct core molecular function."
human	OPLAH	genes/human/OPLAH/OPLAH-ai-review.yaml	OPLAH	O14841	NCBITaxon:9606	Homo sapiens	14	R-HSA-5603208	Defective OPLAH does not hydrolyse OPRO	yes	reactome/R-HSA-5603208.md	Defective OPLAH does not hydrolyse OPRO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing OPLAH in the cytosol. Consistent with the core cytosolic localization.
human	OPLAH	genes/human/OPLAH/OPLAH-ai-review.yaml	OPLAH	O14841	NCBITaxon:9606	Homo sapiens	15	R-HSA-1247935	OPLAH hydrolyses OPRO to L-Glu	yes	reactome/R-HSA-1247935.md	OPLAH hydrolyses OPRO to L-Glu	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author-statement (reaction ""OPLAH hydrolyses OPRO to L-Glu"") placing OPLAH in the cytosol. Duplicates the other cytosol annotations and is consistent with them."
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	56	R-HSA-9824892	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	yes	reactome/R-HSA-9824892.md	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the mitophagy reaction (MAP1LC3B binds phospho-OPTN bound to Ub-mitochondria). Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	57	R-HSA-9824897	p-S-TBK1 phosphorylates OPTN	yes	reactome/R-HSA-9824897.md	p-S-TBK1 phosphorylates OPTN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the mitophagy reaction (phospho-TBK1 phosphorylates OPTN). Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	58	R-HSA-9840807	OPTN binds ATG9A	yes	reactome/R-HSA-9840807.md	OPTN binds ATG9A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the reaction OPTN binds ATG9A. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	60	R-HSA-9793680	OPTN binds polyUb-RIPK1 within the TNFR1 complex	yes	reactome/R-HSA-9793680.md	OPTN binds polyUb-RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN binding polyUb-RIPK1 within the TNFR1 complex. Consistent with the cytosolic site of action in NF-kB regulation.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	61	R-HSA-9823816	OPTN binds CASP8	yes	reactome/R-HSA-9823816.md	OPTN binds CASP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN binding CASP8. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	62	R-HSA-9823934	OPTN binds TBK1 within the activated TLR4 complex	yes	reactome/R-HSA-9823934.md	OPTN binds TBK1 within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN binding TBK1 within the activated TLR4 complex. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	63	R-HSA-9824874	OPTN recruits CYLD to the TNFR1 complex	yes	reactome/R-HSA-9824874.md	OPTN recruits CYLD to the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN recruiting CYLD to the TNFR1 complex. Consistent with the cytosolic site of action in NF-kB regulation.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	64	R-HSA-9824888	OPTN, TBK1 bind ubiquitinated MOM proteins	yes	reactome/R-HSA-9824888.md	OPTN, TBK1 bind ubiquitinated MOM proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN/TBK1 binding ubiquitinated mitochondrial outer-membrane proteins (mitophagy). Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	65	R-HSA-9824894	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	yes	reactome/R-HSA-9824894.md	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for TBK1 phosphorylation within the TBK1:OPTN:Ub-mitochondria complex. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	66	R-HSA-9828209	OPTN binds TBK1 within the activated TLR3 complex	yes	reactome/R-HSA-9828209.md	OPTN binds TBK1 within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for OPTN binding TBK1 within the activated TLR3 complex. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	72	R-HSA-8854182	TBC1D17 binds OPTN:RAB8A	yes	reactome/R-HSA-8854182.md	TBC1D17 binds OPTN:RAB8A	Homo sapiens	GO:0055038	recycling endosome membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization to the recycling-endosome membrane for the reaction TBC1D17 binds OPTN:RAB8A.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	79	R-HSA-2562526	PLK1 phosphorylates OPTN	yes	reactome/R-HSA-2562526.md	PLK1 phosphorylates OPTN	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome Golgi-membrane localization for the reaction PLK1 phosphorylates OPTN.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	80	R-HSA-2562594	Phosphorylated OPTN translocates to the nucleus	yes	reactome/R-HSA-2562594.md	Phosphorylated OPTN translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasm localization for the reaction phosphorylated OPTN translocates to the nucleus (PLK1-phosphorylated pool).
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	81	R-HSA-2562526	PLK1 phosphorylates OPTN	yes	reactome/R-HSA-2562526.md	PLK1 phosphorylates OPTN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the reaction PLK1 phosphorylates OPTN. Consistent with the cytosolic site of action.
human	OPTN	genes/human/OPTN/OPTN-ai-review.yaml	OPTN	Q96CV9	NCBITaxon:9606	Homo sapiens	82	R-HSA-2562594	Phosphorylated OPTN translocates to the nucleus	yes	reactome/R-HSA-2562594.md	Phosphorylated OPTN translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization for the reaction phosphorylated OPTN translocates to the nucleus. Consistent with the cytosolic starting compartment.
human	ORMDL3	genes/human/ORMDL3/ORMDL3-ai-review.yaml	ORMDL3	Q8N138	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		REMOVE	Reactome annotation placing ORMDL3 at the plasma membrane based on neutrophil degranulation pathway. ORMDL3 is an ER-resident protein with no experimental evidence for plasma membrane localization. The original discovery paper (PMID:12093374) explicitly showed no colocalization with plasma membrane markers.
human	ORMDL3	genes/human/ORMDL3/ORMDL3-ai-review.yaml	ORMDL3	Q8N138	NCBITaxon:9606	Homo sapiens	19	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		REMOVE	Second Reactome annotation to plasma membrane from specific granule exocytosis pathway. Same issue as above.
human	ORMDL3	genes/human/ORMDL3/ORMDL3-ai-review.yaml	ORMDL3	Q8N138	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		REMOVE	Reactome annotation placing ORMDL3 in secretory granule membranes from the neutrophil degranulation pathway. While ORMDL3 may have been detected in proteomics of granule fractions, its established function and localization is in the ER as part of the SPT complex.
human	ORMDL3	genes/human/ORMDL3/ORMDL3-ai-review.yaml	ORMDL3	Q8N138	NCBITaxon:9606	Homo sapiens	21	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		REMOVE	Reactome annotation to specific granule membrane from neutrophil-specific granule exocytosis pathway. Same concern as secretory granule membrane.
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	15	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the OST-catalyzed N-glycan transfer reaction at the ER membrane. Correct core cellular location for OSTC as an OST-A subunit.
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	16	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation of ER membrane location via a specific substrate reaction (SARS-CoV-2 spike protein N-glycosylation). Same correct location as the general OST reaction; kept as non-core to avoid inflating substrate-specific reactions into core.
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	17	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane location via a specific substrate reaction (CDH1 N-glycosylation). Correct location; kept as non-core (substrate-specific reaction).
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	18	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane location via a specific viral substrate reaction (flavivirus E protein N-glycosylation). Correct location; kept as non-core (substrate-specific reaction).
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	19	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane location via a specific viral substrate reaction (flavivirus pre-M N-glycosylation). Correct location; kept as non-core (substrate-specific reaction).
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	20	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane location via a specific viral substrate reaction (pre-NS1 N-glycosylation). Correct location; kept as non-core (substrate-specific reaction).
human	OSTC	genes/human/OSTC/OSTC-ai-review.yaml	OSTC	Q9NRP0	NCBITaxon:9606	Homo sapiens	21	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome ER membrane location via a specific substrate reaction (PD-L1/CD274 N-glycosylation). Correct location; kept as non-core (substrate-specific reaction).
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	28	R-HSA-9956527	OTC variants don't synthesize L-citrulline	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of OTC to the mitochondrial matrix within a reaction where OTC variants fail to synthesize L-citrulline. Correct compartment.
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	29	R-HSA-9956513	Leader sequence variants of OTC aren't targeted to the mitochondria	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) cytosol location arising from a model of OTC leader-sequence variants that are NOT targeted to mitochondria. This is a mistrafficking/precursor context, not the localization of the mature functional enzyme.
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	30	R-HSA-9956502	OTC precursor is targeted to the mitochondrial matrix and processed	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome (TAS) cytosol location from a model of OTC precursor targeting to the mitochondrial matrix. The cytosol appears only as the transient location of the newly synthesized precursor before import, not the mature enzyme's compartment.
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	31	R-HSA-9959881	OTC gene expression	no				GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome (TAS) cytosol location from an ""OTC gene expression"" reaction. Reflects the biosynthesis/expression step, not the localization of the functional enzyme."
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	33	R-HSA-8986181	PITRM1 proteolyzes mitochondrial targeting peptides (presequences)	yes	reactome/R-HSA-8986181.md	PITRM1 proteolyzes mitochondrial targeting peptides (presequences)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization within the presequence-proteolysis (PITRM1) reaction. Correct compartment for OTC.
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	45	R-HSA-70560	carbamoyl phosphate + ornithine => citrulline + orthophosphate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization within the core catalytic reaction (carbamoyl phosphate + ornithine => citrulline + orthophosphate). Correct compartment for the functional enzyme.
human	OTC	genes/human/OTC/OTC-ai-review.yaml	OTC	P00480	NCBITaxon:9606	Homo sapiens	46	R-HSA-9956502	OTC precursor is targeted to the mitochondrial matrix and processed	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization from the OTC precursor targeting/processing reaction (post-import, matrix-processed form). Correct compartment for the mature enzyme.
human	OTUD3	genes/human/OTUD3/OTUD3-ai-review.yaml	OTUD3	Q5T2D3	NCBITaxon:9606	Homo sapiens	11	R-HSA-5688426	Reactome: Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	Reactome annotation of OTUD3 protein deubiquitination.
human	OTUD3	genes/human/OTUD3/OTUD3-ai-review.yaml	OTUD3	Q5T2D3	NCBITaxon:9606	Homo sapiens	12	R-HSA-6807206	Reactome: Ovarian tumor domain proteases	yes	reactome/R-HSA-6807206.md	USP13 and OTUD3 deubiquitinate PTEN	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation of OTUD3 cysteine-type deubiquitinase activity.
human	OTUD3	genes/human/OTUD3/OTUD3-ai-review.yaml	OTUD3	Q5T2D3	NCBITaxon:9606	Homo sapiens	13	R-HSA-8873946	Reactome: Regulation of PTEN stability and activity	yes	reactome/R-HSA-8873946.md	OTUD3 deubiquitinates PTEN	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome annotation of OTUD3 cysteine-type deubiquitinase activity (PTEN regulation pathway).
human	OTUD3	genes/human/OTUD3/OTUD3-ai-review.yaml	OTUD3	Q5T2D3	NCBITaxon:9606	Homo sapiens	33	R-HSA-6807206	Reactome: Ovarian tumor domain proteases	yes	reactome/R-HSA-6807206.md	USP13 and OTUD3 deubiquitinate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	OTUD3	genes/human/OTUD3/OTUD3-ai-review.yaml	OTUD3	Q5T2D3	NCBITaxon:9606	Homo sapiens	34	R-HSA-8873946	Reactome: Regulation of PTEN stability and activity	yes	reactome/R-HSA-8873946.md	OTUD3 deubiquitinates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization (PTEN regulation pathway).
human	OXCT1	genes/human/OXCT1/OXCT1-ai-review.yaml	OXCT1	P55809	NCBITaxon:9606	Homo sapiens	22	R-HSA-74177	OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome curation of the SCOT reaction (CoA transfer from succinyl-CoA to acetoacetate) places OXCT1 in the mitochondrial matrix. This is the correct, more specific compartment for the soluble matrix enzyme.
human	OXCT1	genes/human/OXCT1/OXCT1-ai-review.yaml	OXCT1	P55809	NCBITaxon:9606	Homo sapiens	23	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Matrix localization from a Reactome reaction (CLPXP binding of mitochondrial matrix proteins). Localization is correct; the reaction is a generic matrix-protein-handling event.
human	OXCT1	genes/human/OXCT1/OXCT1-ai-review.yaml	OXCT1	P55809	NCBITaxon:9606	Homo sapiens	24	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Matrix localization from a Reactome reaction (LONP1 degradation of mitochondrial matrix proteins). Localization is correct.
human	OXCT1	genes/human/OXCT1/OXCT1-ai-review.yaml	OXCT1	P55809	NCBITaxon:9606	Homo sapiens	25	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Matrix localization from a Reactome reaction (LONP1 binding of mitochondrial matrix proteins). Localization is correct.
human	OXCT1	genes/human/OXCT1/OXCT1-ai-review.yaml	OXCT1	P55809	NCBITaxon:9606	Homo sapiens	26	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Matrix localization from a Reactome reaction (CLPXP degradation of mitochondrial matrix proteins). Localization is correct.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	63	R-HSA-139855	P2X1-mediated entry of Ca++ from plasma	yes	reactome/R-HSA-139855.md	P2X1-mediated entry of Ca++ from plasma	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	64	R-HSA-419490	Binding of ATP to P2X receptors	yes	reactome/R-HSA-419490.md	Binding of ATP to P2X receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	65	R-HSA-877187	P2X7 mediates loss of intracellular K+	yes	reactome/R-HSA-877187.md	P2X7 mediates loss of intracellular K+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	66	R-HSA-877198	P2X7 mediates membrane pores that include pannexin-1	yes	reactome/R-HSA-877198.md	P2X7 mediates membrane pores that include pannexin-1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	67	R-HSA-9660822	ATP binds P2RX4,7	yes	reactome/R-HSA-9660822.md	ATP binds P2RX4,7	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P2RX7	genes/human/P2RX7/P2RX7-ai-review.yaml	P2RX7	Q99572	NCBITaxon:9606	Homo sapiens	68	R-HSA-9665515	P2RX4,7 binds itself to form trimeric non-selective cation channels	yes	reactome/R-HSA-9665515.md	P2RX4,7 binds itself to form trimeric non-selective cation channels	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	P2X7 is a cell-surface receptor whose ATP-binding site faces the extracellular space.
human	P3H1	genes/human/P3H1/P3H1-ai-review.yaml	P3H1	Q32P28	NCBITaxon:9606	Homo sapiens	34	R-HSA-1980233	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	yes	reactome/R-HSA-1980233.md	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H1 in the ER lumen, the soluble compartment where it catalyzes collagen prolyl 3-hydroxylation.
human	P3H1	genes/human/P3H1/P3H1-ai-review.yaml	P3H1	Q32P28	NCBITaxon:9606	Homo sapiens	35	R-HSA-2022073	Procollagen triple helix formation	yes	reactome/R-HSA-2022073.md	Procollagen triple helix formation	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H1 in the ER lumen during procollagen triple-helix formation.
human	P3H1	genes/human/P3H1/P3H1-ai-review.yaml	P3H1	Q32P28	NCBITaxon:9606	Homo sapiens	36	R-HSA-8948226	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	yes	reactome/R-HSA-8948226.md	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H1 in the ER lumen (prolyl 3-hydroxylase complex reaction).
human	P3H1	genes/human/P3H1/P3H1-ai-review.yaml	P3H1	Q32P28	NCBITaxon:9606	Homo sapiens	37	R-HSA-8948230	P3HB binds 4-Hyp-collagen propeptides	yes	reactome/R-HSA-8948230.md	P3HB binds 4-Hyp-collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H1 in the ER lumen (binding of 4-Hyp collagen propeptides).
human	P3H2	genes/human/P3H2/P3H2-ai-review.yaml	P3H2	Q8IVL5	NCBITaxon:9606	Homo sapiens	14	R-HSA-1980233	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	yes	reactome/R-HSA-1980233.md	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation places P3H2 in the ER lumen, the precise compartment where collagen prolyl 3-hydroxylation occurs. This is the most informative cellular-component term for the enzyme.
human	P3H2	genes/human/P3H2/P3H2-ai-review.yaml	P3H2	Q8IVL5	NCBITaxon:9606	Homo sapiens	15	R-HSA-8948226	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	yes	reactome/R-HSA-8948226.md	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H2 in the ER lumen during the collagen 3-hydroxylation reaction cycle.
human	P3H2	genes/human/P3H2/P3H2-ai-review.yaml	P3H2	Q8IVL5	NCBITaxon:9606	Homo sapiens	16	R-HSA-8948230	P3HB binds 4-Hyp-collagen propeptides	yes	reactome/R-HSA-8948230.md	P3HB binds 4-Hyp-collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P3H2 in the ER lumen, where it binds 4-Hyp collagen propeptides.
human	P4HA1	genes/human/P4HA1/P4HA1-ai-review.yaml	P4HA1	P13674	NCBITaxon:9606	Homo sapiens	18	R-HSA-1650808	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	yes	reactome/R-HSA-1650808.md	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation places P4HA1 in the ER lumen, where prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines.
human	P4HA1	genes/human/P4HA1/P4HA1-ai-review.yaml	P4HA1	P13674	NCBITaxon:9606	Homo sapiens	19	R-HSA-9918779	Proline hydroxylases hydroxylate Polyprotein	yes	reactome/R-HSA-9918779.md	Proline hydroxylases hydroxylate Polyprotein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P4HA1 ER lumen localization (proline hydroxylation context).
human	P4HA2	genes/human/P4HA2/P4HA2-ai-review.yaml	P4HA2	O15460	NCBITaxon:9606	Homo sapiens	16	R-HSA-1650808	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	yes	reactome/R-HSA-1650808.md	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation placing the prolyl 4-hydroxylase reaction in the ER lumen (collagen biosynthesis pathway).
human	P4HA2	genes/human/P4HA2/P4HA2-ai-review.yaml	P4HA2	O15460	NCBITaxon:9606	Homo sapiens	17	R-HSA-9918779	Proline hydroxylases hydroxylate Polyprotein	yes	reactome/R-HSA-9918779.md	Proline hydroxylases hydroxylate Polyprotein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of proline hydroxylase activity in the ER lumen (here in a viral polyprotein-maturation context); the compartment assignment is correct.
human	P4HA3	genes/human/P4HA3/P4HA3-ai-review.yaml	P4HA3	Q7Z4N8	NCBITaxon:9606	Homo sapiens	14	R-HSA-1650808	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	yes	reactome/R-HSA-1650808.md	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of P4HA3 in the ER lumen, where the collagen prolyl 4-hydroxylase reaction occurs; consistent with the UniProt subcellular location.
human	P4HA3	genes/human/P4HA3/P4HA3-ai-review.yaml	P4HA3	Q7Z4N8	NCBITaxon:9606	Homo sapiens	15	R-HSA-9918779	Proline hydroxylases hydroxylate Polyprotein	yes	reactome/R-HSA-9918779.md	Proline hydroxylases hydroxylate Polyprotein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER-lumen localization in the context of proline hydroxylation of a (viral) polyprotein substrate; the compartment assignment for P4HA3 is correct.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	30	R-HSA-264876	Reactome: Insulin processing.	no				GO:0030070	insulin processing	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation of insulin processing, consistent with PDI's role in oxidative folding of secretory proteins.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	31	R-HSA-9020591	Reactome: Interleukin-12 signaling.	no				GO:0035722	interleukin-12-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation linking PDI to IL-12 signaling, likely reflecting its role in oxidative folding/redox of immune receptors. A specialized pathway context.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	32	R-HSA-9020933	Reactome: Interleukin-23 signaling.	no				GO:0038155	interleukin-23-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome annotation linking PDI to IL-23 signaling. A specialized pathway context.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	40	R-HSA-264997	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-264997.md	P4HB mediates disulfide bond formation in Proinsulin	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome annotation placing PDI in the ER lumen, consistent with its principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	41	R-HSA-3341296	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	42	R-HSA-9817575	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	43	R-HSA-1650808	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-1650808.md	Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	44	R-HSA-174786	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	45	R-HSA-2002460	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	46	R-HSA-5358336	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-5358336.md	P4HB forms mixed disulphides with Hh precursors	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	47	R-HSA-5358340	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-5358340.md	Autoproteolytic cleavage of Hh precursors	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	48	R-HSA-8866329	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	49	R-HSA-8948234	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	50	R-HSA-8950113	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	51	R-HSA-8950183	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	52	R-HSA-8950456	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	53	R-HSA-8952289	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	54	R-HSA-9737780	Reactome: PDI in ER lumen.	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	P4HB	genes/human/P4HB/P4HB-ai-review.yaml	P4HB	P07237	NCBITaxon:9606	Homo sapiens	55	R-HSA-9918779	Reactome: PDI in ER lumen.	yes	reactome/R-HSA-9918779.md	Proline hydroxylases hydroxylate Polyprotein	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation placing PDI in the ER lumen; redundant with the principal localization.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	48	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	49	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	50	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	51	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	52	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	53	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	54	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	55	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	56	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	57	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	58	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	59	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	60	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	61	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	62	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	63	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	64	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	65	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	66	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	67	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	68	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	69	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	70	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	71	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	72	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	73	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	74	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	75	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	76	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	77	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	78	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	79	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	80	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	81	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	82	R-HSA-8848484	PLA2s hydrolyze phospholipids at the Golgi membrane	yes	reactome/R-HSA-8848484.md	PLA2s hydrolyze phospholipids at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	83	R-HSA-8849350	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	yes	reactome/R-HSA-8849350.md	RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	84	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	85	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAFAH1B1	genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml	PAFAH1B1	P43034	NCBITaxon:9606	Homo sapiens	86	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places LIS1 in the cytosol in dynein-, centrosome-, kinetochore- and cilium-related reactions.
human	PAICS	genes/human/PAICS/PAICS-ai-review.yaml	PAICS	P22234	NCBITaxon:9606	Homo sapiens	40	R-HSA-73805	CAIR + Aspartate + ATP => SAICAR + ADP + Pi	yes	reactome/R-HSA-73805.md	CAIR + Aspartate + ATP => SAICAR + ADP + Pi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization curated by Reactome for the SAICAR synthetase reaction (CAIR + Aspartate + ATP to SAICAR + ADP + Pi). Correct core localization.
human	PAICS	genes/human/PAICS/PAICS-ai-review.yaml	PAICS	P22234	NCBITaxon:9606	Homo sapiens	41	R-HSA-73806	AIR + CO2 => CAIR	yes	reactome/R-HSA-73806.md	AIR + CO2 => CAIR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization curated by Reactome for the AIR carboxylase reaction (AIR + CO2 to CAIR). Correct core localization.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	39	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-asserted nucleoplasm location (HR pathway module). Consistent with PALB2's site of action.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	40	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-asserted nucleoplasm location (defective HR module). Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	44	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location (HR/D-loop pathway). Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	45	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	46	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	47	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	48	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	49	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	50	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	51	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	52	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	53	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Reactome nucleoplasm location for the ""D-loop formation mediated by PALB2, BRCA2 and RAD51"" reaction. Directly relevant and consistent."
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	54	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location (defective D-loop formation module). Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	55	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location. Consistent.
human	PALB2	genes/human/PALB2/PALB2-ai-review.yaml	PALB2	Q86YC2	NCBITaxon:9606	Homo sapiens	56	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome nucleoplasm location (FIGNL1 binds RAD51 module). Consistent.
human	PANK1	genes/human/PANK1/PANK1-ai-review.yaml	PANK1	Q8TE04	NCBITaxon:9606	Homo sapiens	14	R-HSA-196783	Coenzyme A biosynthesis	yes	reactome/R-HSA-196783.md	Coenzyme A biosynthesis	Homo sapiens	GO:0015937	coenzyme A biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of PANK1 in the coenzyme A biosynthesis pathway, in which cytosolic PANK1/PANK3 catalyze the ATP-dependent phosphorylation of pantothenate as the first of five steps. Authoritative and correct; accepted as a core process annotation.
human	PANK1	genes/human/PANK1/PANK1-ai-review.yaml	PANK1	Q8TE04	NCBITaxon:9606	Homo sapiens	23	R-HSA-199203	PANK1/3 phosphorylate PanK	yes	reactome/R-HSA-199203.md	PANK1/3 phosphorylate PanK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) placement of PANK1 in the cytosol, where cytosolic PANK1/PANK3 catalyze the phosphorylation of pantothenate. Redundant with the IBA cytosol annotation and correct. Accepted.
human	PANK2	genes/human/PANK2/PANK2-ai-review.yaml	PANK2	Q9BZ23	NCBITaxon:9606	Homo sapiens	16	R-HSA-196783	Coenzyme A biosynthesis	yes	reactome/R-HSA-196783.md	Coenzyme A biosynthesis	Homo sapiens	GO:0015937	coenzyme A biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-traceable assignment of the core CoA biosynthetic process. PANK2 catalyzes the first of five reactions in CoA biosynthesis from pantothenate.
human	PANK2	genes/human/PANK2/PANK2-ai-review.yaml	PANK2	Q9BZ23	NCBITaxon:9606	Homo sapiens	17	R-HSA-196857	PANK2 phosphorylates PanK	yes	reactome/R-HSA-196857.md	PANK2 phosphorylates PanK	Homo sapiens	GO:0004594	pantothenate kinase activity	TAS	enables	MF	false		ACCEPT	"Reactome-traceable assignment of the core pantothenate kinase activity (""PANK2 phosphorylates PanK""). Consistent with all experimental evidence."
human	PANK2	genes/human/PANK2/PANK2-ai-review.yaml	PANK2	Q9BZ23	NCBITaxon:9606	Homo sapiens	23	R-HSA-196857	PANK2 phosphorylates PanK	yes	reactome/R-HSA-196857.md	PANK2 phosphorylates PanK	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome-traceable IMS localization, consistent with the experimental submitochondrial mapping in PMID:23152917. This is the specific, functionally meaningful location.
human	PANK4	genes/human/PANK4/PANK4-ai-review.yaml	PANK4	Q9NVE7	NCBITaxon:9606	Homo sapiens	8	R-HSA-199220	Pantothenate and CoA biosynthesis	yes	reactome/R-HSA-199220.md	Vitamin B5 (pantothenate) metabolism	Homo sapiens	GO:0015939	pantothenate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Pantothenate metabolic process (TAS), pathway context (CoA/pantothenate).
human	PANK4	genes/human/PANK4/PANK4-ai-review.yaml	PANK4	Q9NVE7	NCBITaxon:9606	Homo sapiens	12	R-HSA-9837419	Metabolism / cytosolic reaction (PANK4)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS).
human	PAOX	genes/human/PAOX/PAOX-ai-review.yaml	PAOX	Q6QHF9	NCBITaxon:9606	Homo sapiens	16	R-HSA-141348	PAO:FAD oxidises NASPM to PTCN	yes	reactome/R-HSA-141348.md	PAO:FAD oxidises NASPM to PTCN	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS peroxisomal matrix, from the reaction ""PAO:FAD oxidises NASPM to PTCN"" (N1-acetylspermidine to putrescine). Consistent with the PTS1 signal and UniProt peroxisome localization. Core compartment."
human	PAOX	genes/human/PAOX/PAOX-ai-review.yaml	PAOX	Q6QHF9	NCBITaxon:9606	Homo sapiens	17	R-HSA-141351	PAOX:FAD oxidises NASPN to SPM	yes	reactome/R-HSA-141351.md	PAOX:FAD oxidises NASPN to SPM	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS peroxisomal matrix, from the reaction ""PAOX:FAD oxidises NASPN to SPM"" (N1-acetylspermine to spermidine). Same well-supported peroxisomal localization. Core compartment (duplicate of the other Reactome/Ensembl matrix annotations)."
human	PAOX	genes/human/PAOX/PAOX-ai-review.yaml	PAOX	Q6QHF9	NCBITaxon:9606	Homo sapiens	18	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS peroxisomal matrix, associated with PAOX being imported as a PTS1 cargo into the peroxisomal matrix (PEX5-mediated translocation). Consistent with the functional localization. Core compartment.
human	PAOX	genes/human/PAOX/PAOX-ai-review.yaml	PAOX	Q6QHF9	NCBITaxon:9606	Homo sapiens	19	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol, reflecting the pre-import (cytosolic) state of PAOX before PEX5-mediated translocation into the peroxisome. Represents a transit pool rather than the functional site. Non-core.
human	PAOX	genes/human/PAOX/PAOX-ai-review.yaml	PAOX	Q6QHF9	NCBITaxon:9606	Homo sapiens	20	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS cytosol, from the step where the PEX5:PAOX (PTS1 cargo) complex binds the peroxisomal docking/translocation module. Again a pre-import transit state; non-core relative to the peroxisomal matrix.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	11	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome reaction ""PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS"" (the APS kinase step of PAPS biosynthesis). Correct core BP. Accept."
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	12	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	"Reactome reaction ""PAPSS1,2 transfer SO4(2-) group to ATP to form APS"" (the ATP sulfurylase step, producing the APS intermediate en route to PAPS). Correct core BP. Accept."
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	13	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0004020	adenylylsulfate kinase activity	TAS	enables	MF	false		ACCEPT	Reactome captures the APS kinase reaction; core MF. Accept.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	14	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0004781	sulfate adenylyltransferase (ATP) activity	TAS	enables	MF	false		ACCEPT	Reactome captures the ATP sulfurylase reaction; core MF. Accept.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	28	R-HSA-6802927	BRAF and RAF fusion mutant dimers are phosphorylated	yes	reactome/R-HSA-6802927.md	BRAF and RAF fusion mutant dimers are phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosol is a correct core location for PAPSS1, but this particular annotation is attached to a ""Signaling by BRAF and RAF1 fusions"" Reactome reaction with which PAPSS1 has no functional relationship; the pathway context is spurious co-occurrence. The location itself is correct and experimentally supported."
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	29	R-HSA-6802932	Dissociation of BRAF/RAF fusion complex	yes	reactome/R-HSA-6802932.md	Dissociation of BRAF/RAF fusion complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol location correct (experimentally supported) though attached to a BRAF/RAF-fusion signaling reaction unrelated to PAPSS1 function.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	30	R-HSA-6802933	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	yes	reactome/R-HSA-6802933.md	p-BRAF and RAF fusion dimers phosphorylate MAP2Ks	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol location correct (experimentally supported) though attached to a BRAF/RAF-fusion signaling reaction unrelated to PAPSS1 function.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	31	R-HSA-6802934	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	yes	reactome/R-HSA-6802934.md	p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol location correct (experimentally supported) though attached to a BRAF/RAF-fusion signaling reaction unrelated to PAPSS1 function.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	32	R-HSA-6802935	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	yes	reactome/R-HSA-6802935.md	MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol location correct (experimentally supported) though attached to a BRAF/RAF-fusion signaling reaction unrelated to PAPSS1 function.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	40	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization supported by Reactome PAPS-biosynthesis reaction and by experimental IDA. Core CC. Accept.
human	PAPSS1	genes/human/PAPSS1/PAPSS1-ai-review.yaml	PAPSS1	O43252	NCBITaxon:9606	Homo sapiens	41	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization supported by Reactome PAPS-biosynthesis reaction and by experimental IDA. Core CC. Accept.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	12	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome reaction for the APS kinase step (APS -> PAPS) that PAPSS2 catalyzes, part of PAPS biosynthesis. Correct core process.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	13	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome reaction for the ATP sulfurylase step (sulfate + ATP -> APS), the first step of PAPS biosynthesis catalyzed by PAPSS2. Correct core process.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	14	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0004020	adenylylsulfate kinase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the APS kinase (adenylyl-sulfate kinase) activity, a core catalytic function of PAPSS2. Retained.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	15	R-HSA-3560785	Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-3560785.md	Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0004020	adenylylsulfate kinase activity	TAS	enables	MF	false		ACCEPT	"Reactome ""Defective PAPSS2"" disease reaction annotating the same core APS kinase activity (the activity lost in SEMD-PA). Molecular function is correct; retained."
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	16	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0004781	sulfate adenylyltransferase (ATP) activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the ATP sulfurylase (sulfate adenylyltransferase (ATP)) activity, the second core catalytic function of PAPSS2. Retained.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	17	R-HSA-3560794	Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-3560794.md	Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0004781	sulfate adenylyltransferase (ATP) activity	TAS	enables	MF	false		ACCEPT	"Reactome ""Defective PAPSS2"" disease reaction annotating the same core ATP sulfurylase activity (the activity lost in SEMD-PA). Molecular function is correct; retained."
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	18	R-HSA-3560785	Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-3560785.md	Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the predominant subcellular location of PAPSS2, consistent with experimental localization data. Correct core location.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	19	R-HSA-3560794	Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-3560794.md	Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome cytosol annotation on the ATP sulfurylase reaction; consistent with the predominant cytosolic localization of PAPSS2. Correct core location.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	29	R-HSA-174389	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	yes	reactome/R-HSA-174389.md	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation on the APS kinase reaction; consistent with the predominant cytosolic localization of PAPSS2. Correct core location.
human	PAPSS2	genes/human/PAPSS2/PAPSS2-ai-review.yaml	PAPSS2	O95340	NCBITaxon:9606	Homo sapiens	30	R-HSA-174392	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	yes	reactome/R-HSA-174392.md	PAPSS1,2 transfer SO4(2-) group to ATP to form APS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation on the ATP sulfurylase reaction; consistent with the predominant cytosolic localization of PAPSS2. Correct core location.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	45	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PAR-3:PAR-6:aPKC complex recruitment.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	46	R-HSA-4608825	DVL2 is phosphorylated after WNT5A binding to FZD	yes	reactome/R-HSA-4608825.md	DVL2 is phosphorylated after WNT5A binding to FZD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for WNT5A signaling.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	47	R-HSA-4608852	SMURF1/2 ubiquitinates PRICKLE1	yes	reactome/R-HSA-4608852.md	SMURF1/2 ubiquitinates PRICKLE1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SMURF1/2 ubiquitination pathway.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	48	R-HSA-4608854	SMURF1/2 are recruited to the DVL2:PARD6A complex	yes	reactome/R-HSA-4608854.md	SMURF1/2 are recruited to the DVL2:PARD6A complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SMURF recruitment.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	49	R-HSA-9013145	RAC1 binds effectors at the plasma membrane	yes	reactome/R-HSA-9013145.md	RAC1 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RAC1 effector binding.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	50	R-HSA-9013157	CDC42 binds effectors at the plasma membrane	yes	reactome/R-HSA-9013157.md	CDC42 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for CDC42 effector binding.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	51	R-HSA-9018766	RHOU binds effectors at the plasma membrane	yes	reactome/R-HSA-9018766.md	RHOU binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RHOU effector binding.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	52	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for PAR complex recruitment to tight junctions.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	53	R-HSA-2160931	Disassembly of tight junctions	yes	reactome/R-HSA-2160931.md	Disassembly of tight junctions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for tight junction disassembly during EMT.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	54	R-HSA-2160932	SMURF1 binds phosphorylated PARD6A	yes	reactome/R-HSA-2160932.md	SMURF1 binds phosphorylated PARD6A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SMURF1 binding to phosphorylated PARD6A.
human	PARD6A	genes/human/PARD6A/PARD6A-ai-review.yaml	PARD6A	Q9NPB6	NCBITaxon:9606	Homo sapiens	55	R-HSA-2160935	SMURF1 ubiquitinates RHOA	yes	reactome/R-HSA-2160935.md	SMURF1 ubiquitinates RHOA	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SMURF1-mediated RHOA ubiquitination.
human	PARD6B	genes/human/PARD6B/PARD6B-ai-review.yaml	PARD6B	Q9BYG5	NCBITaxon:9606	Homo sapiens	32	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PAR complex recruitment to tight junctions.
human	PARD6B	genes/human/PARD6B/PARD6B-ai-review.yaml	PARD6B	Q9BYG5	NCBITaxon:9606	Homo sapiens	33	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for recruitment to tight junctions at plasma membrane.
human	PARD6G	genes/human/PARD6G/PARD6G-ai-review.yaml	PARD6G	Q9BYG4	NCBITaxon:9606	Homo sapiens	20	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization is part of the dynamic localization of PAR6 proteins, which shuttle between cytosol and membrane during polarity establishment.
human	PARD6G	genes/human/PARD6G/PARD6G-ai-review.yaml	PARD6G	Q9BYG4	NCBITaxon:9606	Homo sapiens	21	R-HSA-419981	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	yes	reactome/R-HSA-419981.md	Recruitment of PAR-3:PAR-6:aPKC complex to tight junctions	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization is supported by the Reactome pathway for recruitment of PAR-3:PAR-6:aPKC complex to tight junctions.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	111	R-HSA-4085331	PIAS2-1 SUMOylates PARK7 with SUMO1	yes	reactome/R-HSA-4085331.md	PIAS2-1 SUMOylates PARK7 with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PIAS2-1 SUMOylation of PARK7 with SUMO1. DJ-1 is sumoylated in the nucleoplasm. Consistent with known nuclear localization and SUMO modification.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	122	R-HSA-9641096	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub	yes	reactome/R-HSA-9641096.md	Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for misfolded proteins binding PRKN complex. DJ-1 participates in PINK1-Parkin pathway in cytosol.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	123	R-HSA-9641109	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1	yes	reactome/R-HSA-9641109.md	PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for polyUb-misfolded protein dissociation from PRKN complex.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	124	R-HSA-9641111	Parkin transfers Ub to misfolded proteins	yes	reactome/R-HSA-9641111.md	Parkin transfers Ub to misfolded proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for Parkin ubiquitin transfer to misfolded proteins.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	125	R-HSA-9641127	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins	yes	reactome/R-HSA-9641127.md	Ub:misfolded proteins polymerize to PolyUb:misfolded proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for ubiquitin polymerization on misfolded proteins.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	126	R-HSA-9646348	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	yes	reactome/R-HSA-9646348.md	PolyUb-Misfolded Proteins:HDAC6 bind dynein motor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for polyUb-misfolded proteins binding HDAC6-dynein motor.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	127	R-HSA-9646679	PolyUb-Misfolded proteins bind vimentin to form aggresome	yes	reactome/R-HSA-9646679.md	PolyUb-Misfolded proteins bind vimentin to form aggresome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for aggresome formation with vimentin.
human	PARK7	genes/human/PARK7/PARK7-ai-review.yaml	PARK7	Q99497	NCBITaxon:9606	Homo sapiens	128	R-HSA-9646685	Aggresome dissociates from dynein and microtubule	yes	reactome/R-HSA-9646685.md	Aggresome dissociates from dynein and microtubule	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for aggresome dissociation from dynein and microtubule.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	16	R-HSA-70501	PC carboxylates PYR to OA	no				GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted role of PC in gluconeogenesis, based on the characterized enzymatic reaction (PC carboxylates pyruvate to oxaloacetate).
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	30	R-HSA-2993802	HLCS biotinylates PC:Mn2+	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-asserted cytosolic localization referring to the biotinylation of apo-PC by holocarboxylase synthetase (HLCS) prior to mitochondrial import; the mature enzyme functions in the matrix.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	31	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic assignment for the pre-import step in which biotinylated carboxylases translocate to the mitochondrial matrix.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	32	R-HSA-9035988	Defective HLCS does not biotinylate PC:Mn2+	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic assignment for the defective-HLCS reaction (failure to biotinylate PC:Mn2+), again referring to the pre-import cytosolic state.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	33	R-HSA-3065959	An unknown protease degrades hCBXs	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial-matrix localization (degradation of mitochondrial holocarboxylases). Consistent with the canonical matrix localization of PC.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	34	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial-matrix localization following translocation of biotinylated PC; the functional compartment of the enzyme.
human	PC	genes/human/PC/PC-ai-review.yaml	PC	P11498	NCBITaxon:9606	Homo sapiens	35	R-HSA-70501	PC carboxylates PYR to OA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome localizes the PC-catalyzed carboxylation of pyruvate to oxaloacetate to the mitochondrial matrix.
human	PCBD1	genes/human/PCBD1/PCBD1-ai-review.yaml	PCBD1	P61457	NCBITaxon:9606	Homo sapiens	35	R-HSA-71146	4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing the PCBD1-catalyzed 4a-hydroxy-BH4 dehydration reaction in the cytosol.
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	26	R-HSA-2993447	HLCS biotinylates 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS placing PCCA in the cytosol, reflecting the pre-import apo-precursor and the Reactome ""HLCS biotinylates 6x(PCCA:PCCB)"" / cytosolic-to-matrix translocation events. PCC is not catalytically active in the cytosol."
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	27	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (cytosolic carboxylases translocate to mitochondrial matrix) placing the PCCA precursor in the cytosol prior to import.
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	28	R-HSA-9035990	Defective HLCS does not biotinylate 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS (defective HLCS does not biotinylate 6x(PCCA:PCCB)) placing PCCA in the cytosol as part of the biotinylation/multiple-carboxylase-deficiency pathway.
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	29	R-HSA-3065959	An unknown protease degrades hCBXs	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS assignment of mitochondrial matrix (from the carboxylase degradation reaction). Correct functional compartment.
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	30	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS assignment of mitochondrial matrix (post-translocation destination in the cytosol->matrix translocation reaction). Correct functional compartment.
human	PCCA	genes/human/PCCA/PCCA-ai-review.yaml	PCCA	P05165	NCBITaxon:9606	Homo sapiens	31	R-HSA-71031	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS assignment of mitochondrial matrix, associated with the core PCC reaction (propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + Pi). This is the compartment where the catalytic reaction occurs.
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	20	R-HSA-3065959	An unknown protease degrades hCBXs	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to mitochondrial matrix (in the context of PCC degradation). Consistent with the established matrix localization of PCCB.
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	21	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome TAS annotation to mitochondrial matrix (from the ""Cytosolic carboxylases translocate to mitochondrial matrix"" reaction). Represents the functional matrix compartment of PCC."
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	22	R-HSA-71031	propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to mitochondrial matrix from the PCC catalytic reaction (propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate). Places the enzymatic activity in the matrix.
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	23	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to mitochondrial matrix (LONP1-mediated matrix protein degradation context). Consistent with PCCB being a matrix protein.
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	24	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to mitochondrial matrix (LONP1 binds mitochondrial matrix proteins context). Consistent with the established matrix localization.
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	25	R-HSA-2993447	HLCS biotinylates 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS annotation to cytosol from the ""HLCS biotinylates 6x(PCCA:PCCB)"" reaction, which Reactome models in the cytosol prior to mitochondrial import. This reflects a transient biogenesis stage, not the mature functional compartment."
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	26	R-HSA-3323111	Cytosolic carboxylases translocate to mitochondrial matrix	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS annotation to cytosol from the ""Cytosolic carboxylases translocate to mitochondrial matrix"" reaction, representing the pre-import cytosolic stage of the carboxylase precursor."
human	PCCB	genes/human/PCCB/PCCB-ai-review.yaml	PCCB	P05166	NCBITaxon:9606	Homo sapiens	27	R-HSA-9035990	Defective HLCS does not biotinylate 6x(PCCA:PCCB)	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome TAS annotation to cytosol from the ""Defective HLCS does not biotinylate 6x(PCCA:PCCB)"" reaction, again a cytosolic biogenesis step preceding matrix import."
human	PCYT1A	genes/human/PCYT1A/PCYT1A-ai-review.yaml	PCYT1A	P49585	NCBITaxon:9606	Homo sapiens	41	R-HSA-1483081	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer	yes	reactome/R-HSA-1483081.md	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the active membrane-bound PCYT1 dimer at the ER membrane, where it condenses phosphocholine and CTP to CDP-choline; consistent with the human IDA evidence.
human	PCYT1B	genes/human/PCYT1B/PCYT1B-ai-review.yaml	PCYT1B	Q9Y5K3	NCBITaxon:9606	Homo sapiens	14	R-HSA-1483081	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer	yes	reactome/R-HSA-1483081.md	PCho and CTP are condensed to CDP-Cho by PCYT1 dimer	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The active membrane-bound PCYT1 homodimer condenses phosphocholine and CTP at the ER membrane. More specific than the ER organelle term and consistent with the amphitropic, membrane-activated mechanism.
human	PCYT2	genes/human/PCYT2/PCYT2-ai-review.yaml	PCYT2	Q99447	NCBITaxon:9606	Homo sapiens	13	R-HSA-1483190	PETA and CTP are condensed to CDP-ETA by PCY2	yes	reactome/R-HSA-1483190.md	PETA and CTP are condensed to CDP-ETA by PCY2	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome models the reaction at the ER membrane with a membrane-bound PCY2 dimer, but mammalian ET/PCYT2 is characterized as a soluble cytosolic enzyme (unlike the membrane-associated choline counterpart PCYT1A), and GOA/PAN-GO localizes it to cytoplasm. This ER-membrane assignment likely reflects the site where its product is consumed rather than a bona fide integral-membrane localization of ET; treated as an over-annotation. Retained (not removed) as it is a traceable Reactome statement, but it should not be considered a core location.
human	PDCD6IP	genes/human/PDCD6IP/PDCD6IP-ai-review.yaml	PDCD6IP	Q8WUM4	NCBITaxon:9606	Homo sapiens	81	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible broad or peripheral ALIX/PDCD6IP context: cytosol.
human	PDCD6IP	genes/human/PDCD6IP/PDCD6IP-ai-review.yaml	PDCD6IP	Q8WUM4	NCBITaxon:9606	Homo sapiens	82	R-HSA-9688832	MLKL binds PDCD6IP and SDCBP	yes	reactome/R-HSA-9688832.md	MLKL binds PDCD6IP and SDCBP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible broad or peripheral ALIX/PDCD6IP context: cytosol.
human	PDCD6IP	genes/human/PDCD6IP/PDCD6IP-ai-review.yaml	PDCD6IP	Q8WUM4	NCBITaxon:9606	Homo sapiens	83	R-HSA-9948266	NS3 binds PDCD6IP	yes	reactome/R-HSA-9948266.md	NS3 binds PDCD6IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plausible broad or peripheral ALIX/PDCD6IP context: cytosol.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	27	R-HSA-186785	PDGF-AA clevage by Furin	yes	reactome/R-HSA-186785.md	PDGF-AA clevage by Furin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	28	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	33	R-HSA-186785	PDGF-AA clevage by Furin	yes	reactome/R-HSA-186785.md	PDGF-AA clevage by Furin	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	34	R-HSA-382053	Translocation of PDGF from ER to Golgi	yes	reactome/R-HSA-382053.md	Translocation of PDGF from ER to Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	35	R-HSA-1524182	Activated PLC gamma dissociates from the PDGF receptor	yes	reactome/R-HSA-1524182.md	Activated PLC gamma dissociates from the PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	36	R-HSA-1524186	Phosphorylation of PLCgamma by PDGFR	yes	reactome/R-HSA-1524186.md	Phosphorylation of PLCgamma by PDGFR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	37	R-HSA-186765	PLC-gamma binds to the active receptor	yes	reactome/R-HSA-186765.md	PLC-gamma binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	38	R-HSA-186773	PDGF dimer binds two receptors simultaneously	yes	reactome/R-HSA-186773.md	PDGF dimer binds two receptors simultaneously	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	39	R-HSA-186778	SHP2 binds to the active receptor	yes	reactome/R-HSA-186778.md	SHP2 binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	40	R-HSA-186780	PI3-kinase binds to the active receptor	yes	reactome/R-HSA-186780.md	PI3-kinase binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	41	R-HSA-186785	PDGF-AA clevage by Furin	yes	reactome/R-HSA-186785.md	PDGF-AA clevage by Furin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	42	R-HSA-186800	PI3K catalyses the phosphorylation of PIP2 to PIP3	yes	reactome/R-HSA-186800.md	PI3K catalyses the phosphorylation of PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	43	R-HSA-186819	SH2 domain of Src binds to the active receptor	yes	reactome/R-HSA-186819.md	SH2 domain of Src binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	44	R-HSA-186826	GRB2:SOS1 complex binds to the active receptor	yes	reactome/R-HSA-186826.md	GRB2:SOS1 complex binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	45	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	46	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	47	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	48	R-HSA-380780	Activation of Src	yes	reactome/R-HSA-380780.md	Activation of Src	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	49	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	50	R-HSA-382052	p130Cas and C3G bind PDGFR bound Crk	yes	reactome/R-HSA-382052.md	p130Cas and C3G bind PDGFR bound Crk	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	51	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	52	R-HSA-382055	Grb7 binds to the active PDGF receptor	yes	reactome/R-HSA-382055.md	Grb7 binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	53	R-HSA-382056	Crk binds to the active PDGF receptor	yes	reactome/R-HSA-382056.md	Crk binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	54	R-HSA-382058	Nck binds to the active PDGF receptor	yes	reactome/R-HSA-382058.md	Nck binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	55	R-HSA-389083	Autophosphorylation of PDGF alpha receptors	yes	reactome/R-HSA-389083.md	Autophosphorylation of PDGF alpha receptors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	56	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	57	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	58	R-HSA-9674093	PDGFRs bind type I TKI	yes	reactome/R-HSA-9674093.md	PDGFRs bind type I TKI	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	59	R-HSA-382053	Translocation of PDGF from ER to Golgi	yes	reactome/R-HSA-382053.md	Translocation of PDGF from ER to Golgi	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	60	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	platelet alpha granule lumen is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	61	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is plausible for PDGF-A biosynthesis, storage, or isoform retention but is not the principal site of action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	62	R-HSA-2396337	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	yes	reactome/R-HSA-2396337.md	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	63	R-HSA-389086	Autophosphorylation of PDGF alpha/beta receptors	yes	reactome/R-HSA-389086.md	Autophosphorylation of PDGF alpha/beta receptors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	64	R-HSA-8864036	PTPN12 dephosphorylates PDGFRB at Y1021	yes	reactome/R-HSA-8864036.md	PTPN12 dephosphorylates PDGFRB at Y1021	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	65	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFA	genes/human/PDGFA/PDGFA-ai-review.yaml	PDGFA	P04085	NCBITaxon:9606	Homo sapiens	66	R-HSA-9796072	NFE2L2 dependent PDGFA expression	yes	reactome/R-HSA-9796072.md	NFE2L2 dependent PDGFA expression	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is consistent with secreted, extracellular, and pericellular PDGF-A ligand action.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	68	R-HSA-8865275	PDGF-BB clevage by Furin	yes	reactome/R-HSA-8865275.md	PDGF-BB clevage by Furin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	69	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0005796	Golgi lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi lumen is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	70	R-HSA-1524182	Activated PLC gamma dissociates from the PDGF receptor	yes	reactome/R-HSA-1524182.md	Activated PLC gamma dissociates from the PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	71	R-HSA-1524186	Phosphorylation of PLCgamma by PDGFR	yes	reactome/R-HSA-1524186.md	Phosphorylation of PLCgamma by PDGFR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	72	R-HSA-186765	PLC-gamma binds to the active receptor	yes	reactome/R-HSA-186765.md	PLC-gamma binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	73	R-HSA-186773	PDGF dimer binds two receptors simultaneously	yes	reactome/R-HSA-186773.md	PDGF dimer binds two receptors simultaneously	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	74	R-HSA-186778	SHP2 binds to the active receptor	yes	reactome/R-HSA-186778.md	SHP2 binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	75	R-HSA-186780	PI3-kinase binds to the active receptor	yes	reactome/R-HSA-186780.md	PI3-kinase binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	76	R-HSA-186786	Autophosphorylation of PDGF beta receptors	yes	reactome/R-HSA-186786.md	Autophosphorylation of PDGF beta receptors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	77	R-HSA-186798	GAP binds to PDGF-beta receptors only	yes	reactome/R-HSA-186798.md	GAP binds to PDGF-beta receptors only	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	78	R-HSA-186800	PI3K catalyses the phosphorylation of PIP2 to PIP3	yes	reactome/R-HSA-186800.md	PI3K catalyses the phosphorylation of PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	79	R-HSA-186819	SH2 domain of Src binds to the active receptor	yes	reactome/R-HSA-186819.md	SH2 domain of Src binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	80	R-HSA-186826	GRB2:SOS1 complex binds to the active receptor	yes	reactome/R-HSA-186826.md	GRB2:SOS1 complex binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	81	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	82	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	83	R-HSA-2396337	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	yes	reactome/R-HSA-2396337.md	HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	84	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	85	R-HSA-380780	Activation of Src	yes	reactome/R-HSA-380780.md	Activation of Src	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	86	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	87	R-HSA-382052	p130Cas and C3G bind PDGFR bound Crk	yes	reactome/R-HSA-382052.md	p130Cas and C3G bind PDGFR bound Crk	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	88	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	89	R-HSA-382055	Grb7 binds to the active PDGF receptor	yes	reactome/R-HSA-382055.md	Grb7 binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	90	R-HSA-382056	Crk binds to the active PDGF receptor	yes	reactome/R-HSA-382056.md	Crk binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	91	R-HSA-382058	Nck binds to the active PDGF receptor	yes	reactome/R-HSA-382058.md	Nck binds to the active PDGF receptor	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	92	R-HSA-389083	Autophosphorylation of PDGF alpha receptors	yes	reactome/R-HSA-389083.md	Autophosphorylation of PDGF alpha receptors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	93	R-HSA-389086	Autophosphorylation of PDGF alpha/beta receptors	yes	reactome/R-HSA-389086.md	Autophosphorylation of PDGF alpha/beta receptors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	94	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	95	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	96	R-HSA-8864036	PTPN12 dephosphorylates PDGFRB at Y1021	yes	reactome/R-HSA-8864036.md	PTPN12 dephosphorylates PDGFRB at Y1021	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	97	R-HSA-8865275	PDGF-BB clevage by Furin	yes	reactome/R-HSA-8865275.md	PDGF-BB clevage by Furin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	98	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	99	R-HSA-9674093	PDGFRs bind type I TKI	yes	reactome/R-HSA-9674093.md	PDGFRs bind type I TKI	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	extracellular region is supported for PDGFB in the context of its mature extracellular PDGF ligand function.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	105	R-HSA-382053	Translocation of PDGF from ER to Golgi	yes	reactome/R-HSA-382053.md	Translocation of PDGF from ER to Golgi	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	endoplasmic reticulum lumen is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	106	R-HSA-382053	Translocation of PDGF from ER to Golgi	yes	reactome/R-HSA-382053.md	Translocation of PDGF from ER to Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	107	R-HSA-8865275	PDGF-BB clevage by Furin	yes	reactome/R-HSA-8865275.md	PDGF-BB clevage by Furin	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	108	R-HSA-8865276	PDGF-AB clevage by Furin	yes	reactome/R-HSA-8865276.md	PDGF-AB clevage by Furin	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Golgi membrane is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDGFB	genes/human/PDGFB/PDGFB-ai-review.yaml	PDGFB	P01127	NCBITaxon:9606	Homo sapiens	109	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	platelet alpha granule lumen is supported or plausible for PDGFB but represents a context-specific localization, storage, processing, or downstream biological outcome.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	31	R-HSA-203946	PDK isozymes phosphorylate PDHC subunit E1	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the PDK phosphorylation reaction of the PDHC E1 subunit. Correct compartment.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	32	R-HSA-204169	PDP1,2 dephosphorylate p-lipo-PDH	yes	reactome/R-HSA-204169.md	PDP1,2 dephosphorylate p-lipo-PDH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the PDP1/2 dephosphorylation reaction of phospho-lipo-PDH. Correct compartment.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	33	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the CLPXP protease binding mitochondrial matrix proteins reaction (PDHA1 as a matrix substrate). Location correct.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	34	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the CLPXP degradation of mitochondrial matrix proteins reaction. Location correct.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	35	R-HSA-9861616	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the DLD (E3) dihydrolipoyl dehydrogenation reaction of the PDC. Correct compartment for the PDC.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	36	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the DLAT (E2) acetyl transfer to CoA reaction of the PDC. Correct compartment.
human	PDHA1	genes/human/PDHA1/PDHA1-ai-review.yaml	PDHA1	P08559	NCBITaxon:9606	Homo sapiens	37	R-HSA-9861734	PDH E1 decarboxylates PYR, transferring acetyl to DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS matrix localization associated with the reaction in which PDH E1 decarboxylates pyruvate and transfers acetyl to DLAT. This is PDHA1's own catalytic step and it is placed in the mitochondrial matrix.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	23	R-HSA-203946	PDK isozymes phosphorylate PDHC subunit E1	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing PDHB in the mitochondrial matrix, in the context of PDK phosphorylation of the PDC E1 subunit. Correct, specific compartment.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	24	R-HSA-204169	PDP1,2 dephosphorylate p-lipo-PDH	yes	reactome/R-HSA-204169.md	PDP1,2 dephosphorylate p-lipo-PDH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing PDHB in the mitochondrial matrix, in the context of PDP1/2 dephosphorylation of the PDC. Correct, specific compartment.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	25	R-HSA-9838035	CLPXP binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838035.md	CLPXP binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in a generic matrix-protein context (CLPXP binding matrix proteins). The compartment is correct; the reaction context is generic protein quality control, not PDC function.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	26	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in a generic matrix-protein context (LONP1 degrading matrix proteins). Compartment correct; generic quality-control context.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	27	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in a generic matrix-protein context (LONP1 binding matrix proteins). Compartment correct; generic quality-control context.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	28	R-HSA-9838289	CLPXP degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838289.md	CLPXP degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in a generic matrix-protein context (CLPXP degrading matrix proteins). Compartment correct; generic quality-control context.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	29	R-HSA-9861616	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in the context of the PDC reaction cascade (DLD/E3 dehydrogenating dihydrolipoyl). Correct, specific compartment.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	30	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in the context of the PDC reaction cascade (DLAT/E2 transferring acetyl to CoA). Correct, specific compartment.
human	PDHB	genes/human/PDHB/PDHB-ai-review.yaml	PDHB	P11177	NCBITaxon:9606	Homo sapiens	31	R-HSA-9861734	PDH E1 decarboxylates PYR, transferring acetyl to DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS for mitochondrial matrix localization, in the context of the PDC E1 reaction itself (PDH E1 decarboxylates pyruvate, transferring acetyl to DLAT). Directly relevant to PDHB function; correct, specific compartment.
human	PDHX	genes/human/PDHX/PDHX-ai-review.yaml	PDHX	O00330	NCBITaxon:9606	Homo sapiens	26	R-HSA-203946	PDK isozymes phosphorylate PDHC subunit E1	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to mitochondrial matrix (PDH regulation reaction context). Correct and matches the UniProt subcellular location.
human	PDHX	genes/human/PDHX/PDHX-ai-review.yaml	PDHX	O00330	NCBITaxon:9606	Homo sapiens	27	R-HSA-204169	PDP1,2 dephosphorylate p-lipo-PDH	yes	reactome/R-HSA-204169.md	PDP1,2 dephosphorylate p-lipo-PDH	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to mitochondrial matrix. Correct.
human	PDHX	genes/human/PDHX/PDHX-ai-review.yaml	PDHX	O00330	NCBITaxon:9606	Homo sapiens	28	R-HSA-9861616	DLD dimer dehydrogenates dihydrolipoyl	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to mitochondrial matrix (DLD dehydrogenation reaction context). Correct.
human	PDHX	genes/human/PDHX/PDHX-ai-review.yaml	PDHX	O00330	NCBITaxon:9606	Homo sapiens	29	R-HSA-9861667	DLAT trimer transfers acetyl to CoA	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to mitochondrial matrix (DLAT acetyl transfer reaction context). Correct.
human	PDHX	genes/human/PDHX/PDHX-ai-review.yaml	PDHX	O00330	NCBITaxon:9606	Homo sapiens	30	R-HSA-9861734	PDH E1 decarboxylates PYR, transferring acetyl to DLAT	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to mitochondrial matrix (E1 decarboxylation reaction context). Correct.
human	PDSS1	genes/human/PDSS1/PDSS1-ai-review.yaml	PDSS1	Q5T2R2	NCBITaxon:9606	Homo sapiens	17	R-HSA-2162253	PDSS1,2 ligates FPP to IPPP	yes	reactome/R-HSA-2162253.md	PDSS1,2 ligates FPP to IPPP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Traceable author statement (Reactome) placing the PDSS1/PDSS2 reaction in the mitochondrial matrix. Consistent with the ARBA matrix IEA and with CoQ side-chain assembly at the matrix/inner-membrane face. The precise compartment is not independently demonstrated in the cached primary experimental sources, so keep as a plausible non-core sub-localization.
human	PDSS2	genes/human/PDSS2/PDSS2-ai-review.yaml	PDSS2	Q86YH6	NCBITaxon:9606	Homo sapiens	20	R-HSA-2162253	PDSS1,2 ligates FPP to IPPP	yes	reactome/R-HSA-2162253.md	PDSS1,2 ligates FPP to IPPP	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) places the PDSS1,2-catalyzed FPP + IPP condensation in the mitochondrial matrix. Consistent with the mitochondrial localization of the enzyme and a reasonable, more specific subcompartment assignment for where the reaction occurs.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	16	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"Reactome ""Exocytosis of secretory granule lumen proteins"" (neutrophil degranulation) places PDXK in the extracellular region as part of a bulk secretome pathway. PDXK is a cytosolic enzyme lacking a signal peptide; this is a bystander/secretome annotation, not a functional extracellular location."
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	17	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Same neutrophil-degranulation secretome context (specific granule variant). Bystander extracellular annotation for a cytosolic enzyme; non-core.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	18	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation secretome mapping. PDXK is cytosolic; its presence in granule-lumen proteomes is incidental and does not reflect a core localization.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome neutrophil-degranulation secretome mapping (specific granule). Incidental/bystander localization for a cytosolic enzyme; non-core.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	22	R-HSA-964958	2xPDXK:2xZn2+ phosphorylates PXA	yes	reactome/R-HSA-964958.md	2xPDXK:2xZn2+ phosphorylates PXA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome placement of PDXK in the cytosol as part of the B6 activation pathway. Correct; core location.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	23	R-HSA-964962	2xPDKX:2xZn2+ phosphorylates PDX	yes	reactome/R-HSA-964962.md	2xPDKX:2xZn2+ phosphorylates PDX	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic placement (B6 activation reaction). Correct; core location.
human	PDXK	genes/human/PDXK/PDXK-ai-review.yaml	PDXK	O00764	NCBITaxon:9606	Homo sapiens	24	R-HSA-964970	2xPDXK:2xZn2+ phosphorylates PXL	yes	reactome/R-HSA-964970.md	2xPDXK:2xZn2+ phosphorylates PXL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic placement (B6 activation reaction). Correct; core location.
human	PEA15	genes/human/PEA15/PEA15-ai-review.yaml	PEA15	Q15121	NCBITaxon:9606	Homo sapiens	15	R-HSA-5675206	PEA15 binds MAPK monomers and dimers	yes	reactome/R-HSA-5675206.md	PEA15 binds MAPK monomers and dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytoplasmic/cytosolic localization is consistent with PEA15 signaling regulation.
human	PELO	genes/human/PELO/PELO-ai-review.yaml	PELO	Q9BRX2	NCBITaxon:9606	Homo sapiens	15	R-HSA-9954730	Reactome ribosome quality control reaction (PELO cytosol)	yes	reactome/R-HSA-9954730.md	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization in ribosome-rescue reactions, consistent with PELO's site of action.
human	PELO	genes/human/PELO/PELO-ai-review.yaml	PELO	Q9BRX2	NCBITaxon:9606	Homo sapiens	16	R-HSA-9954919	Reactome ribosome quality control reaction (PELO cytosol)	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization (duplicate context).
human	PELO	genes/human/PELO/PELO-ai-review.yaml	PELO	Q9BRX2	NCBITaxon:9606	Homo sapiens	17	R-HSA-9955731	Reactome ribosome quality control reaction (PELO cytosol)	yes	reactome/R-HSA-9955731.md	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curated cytosolic localization (duplicate context).
human	PEMT	genes/human/PEMT/PEMT-ai-review.yaml	PEMT	Q9UBM1	NCBITaxon:9606	Homo sapiens	12	R-HSA-1483191	Synthesis of PC	yes	reactome/R-HSA-1483191.md	Synthesis of PC	Homo sapiens	GO:0006656	phosphatidylcholine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author statement placing PEMT in phosphatidylcholine biosynthesis (Synthesis of PC pathway). This is the core biological process of PEMT and is well supported. Accept.
human	PEMT	genes/human/PEMT/PEMT-ai-review.yaml	PEMT	Q9UBM1	NCBITaxon:9606	Homo sapiens	13	R-HSA-1483174	PE is methylated to PC by PEMT	yes	reactome/R-HSA-1483174.md	PE is methylated to PC by PEMT	Homo sapiens	GO:0004608	phosphatidylethanolamine N-methyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author statement for the core molecular function, phosphatidylethanolamine N-methyltransferase activity (PE methylated to PC by PEMT). This is the central catalytic function of the enzyme. Accept as core.
human	PEMT	genes/human/PEMT/PEMT-ai-review.yaml	PEMT	Q9UBM1	NCBITaxon:9606	Homo sapiens	15	R-HSA-1483174	PE is methylated to PC by PEMT	yes	reactome/R-HSA-1483174.md	PE is methylated to PC by PEMT	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement localizing the PEMT reaction to the endoplasmic reticulum membrane. This is the precise compartment for this multi-pass membrane enzyme and is more informative than plain ER. Accept.
human	PEX1	genes/human/PEX1/PEX1-ai-review.yaml	PEX1	O43933	NCBITaxon:9606	Homo sapiens	34	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for the PEX1:PEX6:PEX26:ZFAND6 complex activity in dissociating Ub:PEX5L from the DTM and translocating PEX5L to the cytosol. PEX1 is present in the cytosol as part of this pathway.
human	PEX1	genes/human/PEX1/PEX1-ai-review.yaml	PEX1	O43933	NCBITaxon:9606	Homo sapiens	35	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PEX1:PEX6:PEX26 complex binding to the DTM complex. PEX1 participates in this reaction in the cytosol/at the peroxisomal membrane.
human	PEX1	genes/human/PEX1/PEX1-ai-review.yaml	PEX1	O43933	NCBITaxon:9606	Homo sapiens	36	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Another Reactome pathway annotation for PEX1:PEX6:PEX26 complex binding.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	24	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway step describing PEX2:PEX10:PEX12 binding PEX5 and ubiquitin-conjugating enzymes at the peroxisomal membrane. Consistent with established localization.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	25	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX2:PEX10:PEX12 monoubiquitinating PEX5 at Cys11. Peroxisomal membrane localization is correct.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for cargo translocation. PEX10 is at the peroxisomal membrane during this process as part of the DTM.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	27	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX5 cargo binding to the docking and translocation module at the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	28	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX5L monoubiquitination at Cys11 at the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	29	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX1/PEX6-mediated receptor extraction from the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	30	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX5L:PEX7 cargo translocation at the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	31	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for receptor export complex assembly at the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	32	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for PEX5L binding and ubiquitin-conjugating enzyme recruitment at the peroxisomal membrane.
human	PEX10	genes/human/PEX10/PEX10-ai-review.yaml	PEX10	O60683	NCBITaxon:9606	Homo sapiens	33	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome step for receptor export complex assembly at the peroxisomal membrane.
human	PEX11A	genes/human/PEX11A/PEX11A-ai-review.yaml	PEX11A	O75192	NCBITaxon:9606	Homo sapiens	16	R-HSA-1989753	Expression of PEX11A	yes	reactome/R-HSA-1989753.md	Expression of PEX11A	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome entry R-HSA-1989753 describes the expression of PEX11A as part of the PPARA activates gene expression pathway. The TAS annotation for peroxisomal membrane localization is consistent with all experimental evidence.
human	PEX11B	genes/human/PEX11B/PEX11B-ai-review.yaml	PEX11B	O96011	NCBITaxon:9606	Homo sapiens	17	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation from R-HSA-9603775 (PEX3:PEX19:class I PMP dissociates). This represents the Reactome model of PEX11B (as a class I PMP) being delivered to the peroxisomal membrane by the PEX19-PEX3 import pathway. PEX11B is released at the peroxisomal membrane.
human	PEX11B	genes/human/PEX11B/PEX11B-ai-review.yaml	PEX11B	O96011	NCBITaxon:9606	Homo sapiens	18	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from R-HSA-9603775 (PEX3:PEX19:class I PMP dissociates). This reflects the transient cytosolic state of PEX11B as a newly synthesized PMP before it is chaperoned by PEX19 to the peroxisomal membrane.
human	PEX11B	genes/human/PEX11B/PEX11B-ai-review.yaml	PEX11B	O96011	NCBITaxon:9606	Homo sapiens	19	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from R-HSA-9603784 (PEX19:class I PMP binds PEX3). This again reflects the cytosolic complex formation between PEX19-PEX11B before docking at PEX3 on the peroxisomal membrane.
human	PEX11B	genes/human/PEX11B/PEX11B-ai-review.yaml	PEX11B	O96011	NCBITaxon:9606	Homo sapiens	20	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from R-HSA-9603804 (PEX19 binds class I peroxisomal membrane proteins). This reflects initial PEX19 recognition of PEX11B in the cytosol.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	30	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation from the PEX3-PEX19-PMP dissociation pathway. PEX12 is synthesized in the cytosol before being targeted to the peroxisomal membrane via PEX19-PEX3 pathway. The cytosolic localization represents a transient biosynthetic intermediate.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	31	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome PEX19-PEX3 pathway. Same rationale as above.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	32	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate cytosol annotation from Reactome PEX19 binding pathway. Same rationale as above.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	33	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX2:PEX10:PEX12 binding PEX5 and Ub:UBE2D at the peroxisomal membrane. Consistent with PEX12's established localization.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	34	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX2:PEX10:PEX12 monoubiquitination of PEX5 at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	35	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cargo translocation step at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	36	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX5:Cargo binding to the docking and translocation module at the peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	37	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX5L monoubiquitination at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	38	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6 mediated receptor extraction at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	39	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PTS2 pathway cargo translocation at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	40	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6:PEX26 binding at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	41	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for E2 binding at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	42	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6:PEX26 complex binding at peroxisomal membrane.
human	PEX12	genes/human/PEX12/PEX12-ai-review.yaml	PEX12	O00623	NCBITaxon:9606	Homo sapiens	43	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX3:PEX19:PMP dissociation at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	21	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PEX3:PEX19:class I PMP dissociation reaction. PEX13 as a class I PMP would transiently be in the cytosol as a PEX19-bound intermediate before membrane insertion. This represents a transient biosynthetic intermediate state, not a steady-state localization.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	22	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PEX19:class I PMP binding PEX3. Same as above; PEX13 transiently passes through cytosol as PEX19-bound intermediate.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	23	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PEX19 binding class I PMPs. PEX13 transiently in cytosol as newly synthesized protein before PEX19-mediated targeting to peroxisomes.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	24	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction where PEX2:PEX10:PEX12 binds PEX5 in the PEX5:PEX13:PEX14 complex. PEX13 is correctly placed at the peroxisomal membrane in this reaction.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	25	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX5 monoubiquitination. PEX13 at peroxisomal membrane as part of the DTM during the ubiquitination step.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for cargo translocation from cytosol to peroxisomal matrix. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	27	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX5:Cargo binding the DTM (PEX13:PEX14:PEX2:PEX10:PEX12). PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	28	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX5L monoubiquitination. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	29	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX1:PEX6 extracting PEX5L from the DTM. PEX13 at peroxisomal membrane as part of the complex from which PEX5 is extracted.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	30	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PTS2 cargo translocation. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	31	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for DTM-REM complex assembly. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	32	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for E3 ligase binding PEX5L in the PTS2 pathway complex. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	33	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for Ub-PEX5:PEX13:PEX14 binding PEX1:PEX6:PEX26. PEX13 at peroxisomal membrane.
human	PEX13	genes/human/PEX13/PEX13-ai-review.yaml	PEX13	Q92968	NCBITaxon:9606	Homo sapiens	34	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX3:PEX19:PMP dissociation. PEX13 as a class I PMP is inserted into the peroxisomal membrane in this step.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	38	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation indicating PEX14 is in the cytosol in the context of PEX3:PEX19:PMP dissociation. PEX14 is primarily a peroxisomal membrane protein but may transiently exist in the cytosol during its biogenesis (as a PEX19 cargo before membrane insertion).
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	39	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PEX19:class I PMP binding to PEX3. PEX14 is transiently cytosolic as a PEX19 cargo.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	40	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for PEX19 binding class I PMPs. PEX14 is transiently cytosolic when bound to PEX19.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	41	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX2:PEX10:PEX12 binding PEX5 in PEX5:PEX13:PEX14 complex. Confirms PEX14 at the peroxisomal membrane in the import complex.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	42	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ubiquitination of PEX5 at the DTM.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	43	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cargo translocation to peroxisomal matrix. PEX14 is at the peroxisomal membrane as part of the DTM.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	44	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX5:Cargo binding DTM.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	45	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX5L ubiquitination at DTM.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	46	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6 dissociating PEX5 from PEX14:PEX13 complex.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	47	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PTS2 cargo translocation.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	48	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6:PEX26 binding DTM complex.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	49	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX2:PEX10:PEX12 binding PEX5L in DTM context.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	50	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX1:PEX6:PEX26 binding to ubiquitinated PEX5:PEX13:PEX14.
human	PEX14	genes/human/PEX14/PEX14-ai-review.yaml	PEX14	O75381	NCBITaxon:9606	Homo sapiens	51	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX3:PEX19:PMP dissociation at the peroxisomal membrane.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	5	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for peroxisomal membrane localization in the context of PEX3:PEX19:class I PMP dissociation. PEX16 is located at the peroxisomal membrane where PEX3-PEX19-PMP complexes dock.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	6	R-NUL-9604086	PEX19:Pex3 binds PEX16	yes	reactome/R-NUL-9604086.md	PEX19:Pex3 binds PEX16	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for peroxisomal membrane in the context of PEX19:Pex3 binding PEX16. PEX16 serves as the membrane-anchored receptor at the peroxisomal membrane.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	7	R-NUL-9604116	PEX16:PEX19:Pex3 dissociates	yes	reactome/R-NUL-9604116.md	PEX16:PEX19:Pex3 dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for peroxisomal membrane in the context of PEX16:PEX19:Pex3 dissociation.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	8	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Reactome annotation placing PEX16 in the cytosol. However, PEX16 is an integral membrane protein that is never found in the cytosol. Cell fractionation shows PEX16 resides only in the membrane fraction (PMID:16717127). This Reactome annotation likely refers to the cytosolic face of PEX16 (both N- and C-termini are cytosolic) or to other participants in the reaction, not to PEX16 itself being a cytosolic protein.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	9	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Reactome annotation placing PEX16 in cytosol for the PEX19:class I PMP binds PEX3 reaction. PEX16 is an integral membrane protein and is not cytosolic.
human	PEX16	genes/human/PEX16/PEX16-ai-review.yaml	PEX16	Q9Y5Y5	NCBITaxon:9606	Homo sapiens	10	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Reactome annotation placing PEX16 in cytosol for the PEX19 binds class I PMPs reaction. PEX16 is an integral membrane protein and is not cytosolic.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	39	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX19 docking ABCD1/D2/D3 to peroxisomal membrane. PEX19 acts in the cytosol as a carrier for ABC transporters.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	40	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX3:PEX19:class I PMP dissociation. PEX19 acts in the cytosol.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	41	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX19:class I PMP binding PEX3. PEX19 acts in the cytosol.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	42	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX19 binding class I PMPs. PEX19 acts in the cytosol.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	43	R-NUL-9604086	PEX19:Pex3 binds PEX16	yes	reactome/R-NUL-9604086.md	PEX19:Pex3 binds PEX16	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX19:Pex3 binding PEX16. PEX19 acts in the cytosol.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	44	R-NUL-9604093	PEX19 binds Pex3	yes	reactome/R-NUL-9604093.md	PEX19 binds Pex3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX19 binding Pex3. PEX19 acts in the cytosol.
human	PEX19	genes/human/PEX19/PEX19-ai-review.yaml	PEX19	P40855	NCBITaxon:9606	Homo sapiens	45	R-NUL-9604116	PEX16:PEX19:Pex3 dissociates	yes	reactome/R-NUL-9604116.md	PEX16:PEX19:Pex3 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for PEX16:PEX19:Pex3 dissociation. PEX19 acts in the cytosol.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	31	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome R-HSA-9603775 models PEX3:PEX19:class I PMP dissociation. PEX2 is a class I peroxisomal membrane protein that transits through the cytosol bound to PEX19 before membrane insertion. This represents a transient cytosolic intermediate.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	32	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome R-HSA-9603784 models PEX19:class I PMP binding to PEX3. Same cytosolic transit as above.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	33	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome R-HSA-9603804 models PEX19 binding to class I PMPs. Same cytosolic transit as above.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	34	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-8953917 models PEX2:PEX10:PEX12 binding PEX5 and Ub:UBE2D for ubiquitination. PEX2 functions at the peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	35	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-8953946 models PEX2:PEX10:PEX12 monoubiquitinating PEX5 at cysteine-11. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	36	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033235 models cargo translocation from cytosol to peroxisomal matrix. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	37	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033236 models PEX5:cargo binding to the docking/translocation module. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	38	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033485 models PEX2:PEX10:PEX12 monoubiquitinating PEX5L at cysteine-11. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	39	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033499 models PEX1:PEX6 dissociating Ub:PEX5 from PEX14:PEX13: PEX2:PEX10:PEX12. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	40	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033514 models cargo translocation for PEX5L:PEX7 pathway. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	41	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033516 models PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binding PEX1:PEX6:PEX26 and ZFAND6. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	42	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033527 models PEX2:PEX10:PEX12 binding PEX5L and Ub:UBE2D. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	43	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9033533 models Ub:PEX5:PEX13:PEX14:PEX2:PEX10:PEX12 binding PEX1:PEX6:PEX26 and ZFAND6. PEX2 at peroxisomal membrane.
human	PEX2	genes/human/PEX2/PEX2-ai-review.yaml	PEX2	P28328	NCBITaxon:9606	Homo sapiens	44	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9603775 models PEX3:PEX19:class I PMP dissociation. PEX2 at peroxisomal membrane after insertion.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	19	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome annotation reflects PEX26's involvement in the PEX3:PEX19:class I PMP dissociation reaction, where PEX19-bound PMPs (including PEX26) transit through the cytosol before membrane insertion. PEX26 is synthesized in the cytosol and transiently present there before insertion into the peroxisomal membrane via the PEX19/PEX3 pathway. However, PEX26's functional localization is the peroxisomal membrane.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	20	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Another Reactome annotation for PEX19:class I PMP binding to PEX3, reflecting the cytosolic transit of PEX26 during PMP import. Same considerations as above.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	21	R-HSA-9603804	PEX19 binds class I peroxisomal membrane proteins	yes	reactome/R-HSA-9603804.md	PEX19 binds class I peroxisomal membrane proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation reflecting PEX19 binding to class I PMPs (including PEX26) in the cytosol. Same considerations as the other cytosol annotations.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	22	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	This Reactome reaction describes PEX1:PEX6:PEX26:ZFAND6 dissociating Ub:PEX5L and PEX7 from the docking/translocation module (PEX14:PEX13:PEX2:PEX10:PEX12). PEX26 is correctly annotated to the peroxisomal membrane in this context as part of the receptor export module.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	23	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction describing binding of the ubiquitinated PEX5L:PEX7 docking complex to PEX1:PEX6:PEX26 and ZFAND6 at the peroxisomal membrane. Correctly places PEX26 at the peroxisomal membrane.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	24	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX5S/L receptor recycling at the peroxisomal membrane. Same context as other Reactome peroxisomal membrane annotations.
human	PEX26	genes/human/PEX26/PEX26-ai-review.yaml	PEX26	Q7Z412	NCBITaxon:9606	Homo sapiens	25	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome reaction for PEX3:PEX19:class I PMP dissociation. PEX26 is annotated to peroxisomal membrane as the destination of PMP import. Correct.
human	PEX3	genes/human/PEX3/PEX3-ai-review.yaml	PEX3	P56589	NCBITaxon:9606	Homo sapiens	37	R-HSA-382613	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	yes	reactome/R-HSA-382613.md	PEX-19 docks ABCD1/D2/D3 to peroximal membrane	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PEX3 involvement in docking of ABCD1/D2/D3 (ABC transporters) to the peroxisomal membrane via PEX19. This is consistent with PEX3's role as the membrane docking factor for the PEX19-PMP import pathway.
human	PEX3	genes/human/PEX3/PEX3-ai-review.yaml	PEX3	P56589	NCBITaxon:9606	Homo sapiens	38	R-HSA-9603775	PEX3:PEX19:class I PMP dissociates	yes	reactome/R-HSA-9603775.md	PEX3:PEX19:class I PMP dissociates	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PEX3:PEX19:class I PMP complex dissociation at the peroxisomal membrane. This correctly places PEX3 at the peroxisomal membrane during PMP release.
human	PEX3	genes/human/PEX3/PEX3-ai-review.yaml	PEX3	P56589	NCBITaxon:9606	Homo sapiens	39	R-HSA-9603784	PEX19:class I PMP binds PEX3	yes	reactome/R-HSA-9603784.md	PEX19:class I PMP binds PEX3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PEX19:class I PMP binding to PEX3 at the peroxisomal membrane. This correctly represents the docking step.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	61	R-HSA-9664855	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664855.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	62	R-HSA-9664862	ATM dimer:PEX5 phosphorylates PEX5	yes	reactome/R-HSA-9664862.md	ATM dimer:PEX5 phosphorylates PEX5	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	63	R-HSA-9664879	ATM:PEX5 binds ATM	yes	reactome/R-HSA-9664879.md	ATM:PEX5 binds ATM	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	64	R-HSA-9664880	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	yes	reactome/R-HSA-9664880.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	65	R-HSA-9664881	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664881.md	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	66	R-HSA-9664883	ATM:PEX5 translocates from cytosol to peroxisomal membrane	yes	reactome/R-HSA-9664883.md	ATM:PEX5 translocates from cytosol to peroxisomal membrane	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	67	R-HSA-9664888	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9664888.md	ATM dimer:p-PEX5 ubiquitinates to form ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	68	R-HSA-9664892	SQSTM1 binds ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9664892.md	SQSTM1 binds ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	69	R-HSA-9674127	USP30 deubiquitinates ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9674127.md	USP30 deubiquitinates ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	70	R-HSA-9674131	USP30 binds ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9674131.md	USP30 binds ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	72	R-HSA-8953917	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-8953917.md	PEX2:PEX10:PEX12 binds PEX5S,L (in PEX5S:PEX13:PEX14) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	73	R-HSA-8953946	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	yes	reactome/R-HSA-8953946.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	74	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	75	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	76	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	77	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	78	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	79	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	80	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for peroxisomal membrane localization. PEX5 transiently associates with the peroxisomal membrane during the import cycle via docking with PEX13/PEX14. Multiple Reactome reactions represent different steps of the import and recycling cycle at the membrane.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	81	R-HSA-9033491	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin	yes	reactome/R-HSA-9033491.md	USP9X hydrolyzes Ub:PEX5L yielding PEX5L and Ubiquitin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	82	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	83	R-HSA-9033509	USP9X binds Ub:PEX5L	yes	reactome/R-HSA-9033509.md	USP9X binds Ub:PEX5L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	84	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	85	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	86	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	87	R-HSA-9664850	ATM binds PEX5	yes	reactome/R-HSA-9664850.md	ATM binds PEX5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX5	genes/human/PEX5/PEX5-ai-review.yaml	PEX5	P50542	NCBITaxon:9606	Homo sapiens	88	R-HSA-9664883	ATM:PEX5 translocates from cytosol to peroxisomal membrane	yes	reactome/R-HSA-9664883.md	ATM:PEX5 translocates from cytosol to peroxisomal membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization. PEX5 is predominantly cytosolic and returns to the cytosol after each import cycle.
human	PEX6	genes/human/PEX6/PEX6-ai-review.yaml	PEX6	Q13608	NCBITaxon:9606	Homo sapiens	33	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for the PEX1-PEX6-PEX26-ZFAND6 complex dissociating Ub:PEX5L from the DTM. The complex acts in the cytosol during PEX5 extraction/recycling.
human	PEX6	genes/human/PEX6/PEX6-ai-review.yaml	PEX6	Q13608	NCBITaxon:9606	Homo sapiens	34	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for binding of PEX1-PEX6-PEX26 and ZFAND6 to PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 complex.
human	PEX6	genes/human/PEX6/PEX6-ai-review.yaml	PEX6	Q13608	NCBITaxon:9606	Homo sapiens	35	R-HSA-9033533	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033533.md	PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for binding of PEX1-PEX6-PEX26 and ZFAND6 to PEX2:PEX10:PEX12:Ub:PEX5S,L:PEX13:PEX14 complex.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	25	R-HSA-9033485	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	yes	reactome/R-HSA-9033485.md	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for peroxisomal membrane from Reactome. This reaction describes PEX2:PEX10:PEX12 monoubiquitination of PEX5L at the peroxisomal membrane. PEX7 is transiently associated with the peroxisomal membrane during the import cycle when it docks at the PEX13-PEX14 complex as part of the PEX5L-PEX7-cargo trimeric complex.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	26	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for peroxisomal membrane from Reactome. This reaction describes PEX1:PEX6:PEX26 dissociating PEX5L and PEX7 from the peroxisomal membrane for recycling.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	27	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for peroxisomal membrane from Reactome. This reaction describes translocation of PEX5L:PEX7 cargo from cytosol to peroxisomal matrix, during which PEX7 passes through the membrane.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	28	R-HSA-9033516	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	yes	reactome/R-HSA-9033516.md	PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for peroxisomal membrane from Reactome. Describes PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binding to PEX1:PEX6:PEX26 complex at the membrane.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	29	R-HSA-9033527	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	yes	reactome/R-HSA-9033527.md	PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3	Homo sapiens	GO:0005778	peroxisomal membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for peroxisomal membrane from Reactome. Describes PEX2:PEX10:PEX12 binding PEX5L within the membrane-associated complex containing PEX7.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	30	R-HSA-9033232	PEX7 binds cargo proteins containing PTS2	yes	reactome/R-HSA-9033232.md	PEX7 binds cargo proteins containing PTS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome. This reaction describes PEX7 binding cargo proteins containing PTS2 in the cytosol.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	31	R-HSA-9033499	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	yes	reactome/R-HSA-9033499.md	PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome. Describes PEX7 recycling from peroxisomal membrane back to cytosol.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	32	R-HSA-9033514	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033514.md	Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome. Cargo translocation from cytosol to matrix involves PEX7 starting in the cytosol.
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	33	R-NUL-9033857	Pex14 binds PEX5L (in PEX5L:PEX7:Acaa1a)	yes	reactome/R-NUL-9033857.md	Pex14 binds PEX5L (in PEX5L:PEX7:Acaa1a)	Cricetulus griseus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (non-human species reaction). Describes Pex14 binding PEX5L:PEX7:Acaa1a in the cytosol (mouse reaction used to infer human).
human	PEX7	genes/human/PEX7/PEX7-ai-review.yaml	PEX7	O00628	NCBITaxon:9606	Homo sapiens	34	R-NUL-9033896	PEX5L binds PEX7:Acaa1a	yes	reactome/R-NUL-9033896.md	PEX5L binds PEX7:Acaa1a	Cricetulus griseus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome (non-human species reaction). Describes PEX5L binding PEX7:Acaa1a in cytosol (mouse reaction).
human	PFAS	genes/human/PFAS/PFAS-ai-review.yaml	PFAS	O15067	NCBITaxon:9606	Homo sapiens	9	R-HSA-73817	Purine ribonucleoside monophosphate biosynthesis	yes	reactome/R-HSA-73817.md	Purine ribonucleoside monophosphate biosynthesis	Homo sapiens	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway-level assertion that PFAS participates in purine ribonucleoside monophosphate (IMP) biosynthesis.
human	PFAS	genes/human/PFAS/PFAS-ai-review.yaml	PFAS	O15067	NCBITaxon:9606	Homo sapiens	10	R-HSA-73812	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi	yes	reactome/R-HSA-73812.md	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi	Homo sapiens	GO:0004642	phosphoribosylformylglycinamidine synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of FGAM synthase activity, citing the biochemically characterized human enzyme reaction FGAR + L-glutamine + ATP + H2O -> FGAM + L-glutamate + ADP + Pi.
human	PFAS	genes/human/PFAS/PFAS-ai-review.yaml	PFAS	O15067	NCBITaxon:9606	Homo sapiens	22	R-HSA-73812	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi	yes	reactome/R-HSA-73812.md	FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that the enzyme is cytosolic, from fluorescence microscopy of cultured human cells.
human	PFKM	genes/human/PFKM/PFKM-ai-review.yaml	PFKM	P08237	NCBITaxon:9606	Homo sapiens	26	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome (Glycolysis) traceable assertion that PFKM participates in canonical glycolysis.
human	PFKM	genes/human/PFKM/PFKM-ai-review.yaml	PFKM	P08237	NCBITaxon:9606	Homo sapiens	38	R-HSA-70467	PFK tetramer phosphorylates Fru(6)P	yes	reactome/R-HSA-70467.md	PFK tetramer phosphorylates Fru(6)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that the PFK tetramer acts in the cytosol (PFK tetramer phosphorylates Fru(6)P).
human	PGAM2	genes/human/PGAM2/PGAM2-ai-review.yaml	PGAM2	P15259	NCBITaxon:9606	Homo sapiens	20	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing the reversible phosphoglycerate mutase reaction within gluconeogenesis. The reaction is genuinely part of the gluconeogenic sequence (a reverse-of-glycolysis step).
human	PGAM2	genes/human/PGAM2/PGAM2-ai-review.yaml	PGAM2	P15259	NCBITaxon:9606	Homo sapiens	21	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation placing PGAM within canonical glycolysis (the cytosolic glucose-to-pyruvate route). Core process for PGAM2.
human	PGAM2	genes/human/PGAM2/PGAM2-ai-review.yaml	PGAM2	P15259	NCBITaxon:9606	Homo sapiens	28	R-HSA-71445	PGAM dimers isomerise 2PG to 3PG	yes	reactome/R-HSA-71445.md	PGAM dimers isomerise 2PG to 3PG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of the cytosol as the location where PGAM dimers isomerise 2PG to 3PG. Core, correct location.
human	PGAM2	genes/human/PGAM2/PGAM2-ai-review.yaml	PGAM2	P15259	NCBITaxon:9606	Homo sapiens	29	R-HSA-71654	PGAM dimers isomerise 3PG to 2PG	yes	reactome/R-HSA-71654.md	PGAM dimers isomerise 3PG to 2PG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of the cytosol as the location where PGAM dimers isomerise 3PG to 2PG. Core, correct location (duplicate direction of the same reversible reaction).
human	PGAP1	genes/human/PGAP1/PGAP1-ai-review.yaml	PGAP1	Q75T13	NCBITaxon:9606	Homo sapiens	5	R-HSA-162791	Attachment of GPI anchor to uPAR	yes	reactome/R-HSA-162791.md	Attachment of GPI anchor to uPAR	Homo sapiens	GO:0016255	attachment of GPI anchor to protein	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Reactome traceable annotation placing PGAP1 in the ""Attachment of GPI anchor to uPAR"" pathway. PGAP1 does not catalyze the transamidase attachment step; it acts immediately after attachment, deacylating the inositol of the already-transferred anchor as the first post-attachment remodeling step."
human	PGAP1	genes/human/PGAP1/PGAP1-ai-review.yaml	PGAP1	Q75T13	NCBITaxon:9606	Homo sapiens	10	R-HSA-162729	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid	yes	reactome/R-HSA-162729.md	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid	Homo sapiens	GO:0016788	hydrolase activity, acting on ester bonds	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation of ester-bond hydrolase activity, based on the modeled reaction uPAR-acyl-GPI + H2O to uPAR + long-chain fatty acid in the ER. Correct broad classification of the deacylation (ester hydrolysis) reaction.
human	PGAP1	genes/human/PGAP1/PGAP1-ai-review.yaml	PGAP1	Q75T13	NCBITaxon:9606	Homo sapiens	11	R-HSA-162729	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid	yes	reactome/R-HSA-162729.md	uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the PGAP1 deacylation reaction at the ER membrane. Consistent with the SubCell IEA, ISS, and experimental data.
human	PGD	genes/human/PGD/PGD-ai-review.yaml	PGD	P52209	NCBITaxon:9606	Homo sapiens	18	R-HSA-71299	PGD decarboxylates 6-phospho-D-gluconate	yes	reactome/R-HSA-71299.md	PGD decarboxylates 6-phospho-D-gluconate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing PGD's decarboxylation reaction in the cytosol. Consistent with all other localization evidence.
human	PGD	genes/human/PGD/PGD-ai-review.yaml	PGD	P52209	NCBITaxon:9606	Homo sapiens	19	R-HSA-9761846	NFE2L2-dependent PGD gene expression	yes	reactome/R-HSA-9761846.md	NFE2L2-dependent PGD gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (NFE2L2-dependent PGD gene expression context) placing PGD in the cytosol. Duplicate cytosol localization.
human	PGGT1B	genes/human/PGGT1B/PGGT1B-ai-review.yaml	PGGT1B	P53609	NCBITaxon:9606	Homo sapiens	14	R-HSA-9947999	FNTA:PGGT1B geranylgeranylates GBP2	yes	reactome/R-HSA-9947999.md	FNTA:PGGT1B geranylgeranylates GBP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (GBP2 geranylgeranylation reaction) places the FNTA/PGGT1B enzyme in the cytosol. Consistent with soluble GGTase-I acting on cytosolic substrate GTPases prior to their membrane targeting. Accepted as a supporting (non-core) localization.
human	PGGT1B	genes/human/PGGT1B/PGGT1B-ai-review.yaml	PGGT1B	P53609	NCBITaxon:9606	Homo sapiens	15	R-HSA-9954195	FNTA:PGGT1B geranylgeranylates GBP5	yes	reactome/R-HSA-9954195.md	FNTA:PGGT1B geranylgeranylates GBP5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (GBP5 geranylgeranylation reaction) places the FNTA/PGGT1B enzyme in the cytosol. Duplicate of the GBP2-reaction cytosol annotation; accepted as a supporting (non-core) localization.
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	24	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation of involvement in gluconeogenesis.
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	25	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation of involvement in canonical glycolysis.
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	28	R-HSA-9975250	PGK1 phosphorylates AKT1S1	yes	reactome/R-HSA-9975250.md	PGK1 phosphorylates AKT1S1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome traceable-author-statement annotation of the moonlighting protein serine/threonine kinase activity (PGK1 phosphorylating AKT1S1/PRAS40).
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	53	R-HSA-70486	PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG	yes	reactome/R-HSA-70486.md	PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation of cytosolic localization (PGK complexes phosphorylating 3PG).
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	54	R-HSA-71850	PGK complexes dephosphorylate 1,3BPG	yes	reactome/R-HSA-71850.md	PGK complexes dephosphorylate 1,3BPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation of cytosolic localization (PGK complexes dephosphorylating 1,3BPG, the gluconeogenic direction).
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	55	R-HSA-9636658	EsxA binds PGK1	yes	reactome/R-HSA-9636658.md	EsxA binds PGK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation of cytosolic localization (in the context of EsxA binding PGK1).
human	PGK1	genes/human/PGK1/PGK1-ai-review.yaml	PGK1	P00558	NCBITaxon:9606	Homo sapiens	56	R-HSA-9975250	PGK1 phosphorylates AKT1S1	yes	reactome/R-HSA-9975250.md	PGK1 phosphorylates AKT1S1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation of cytosolic localization (in the context of PGK1 phosphorylating AKT1S1).
human	PGLS	genes/human/PGLS/PGLS-ai-review.yaml	PGLS	O95336	NCBITaxon:9606	Homo sapiens	11	R-HSA-71336	Pentose phosphate pathway	yes	reactome/R-HSA-71336.md	Pentose phosphate pathway	Homo sapiens	GO:0006098	pentose-phosphate shunt	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement annotation placing PGLS in the pentose phosphate pathway. Correct; PGLS catalyses step 2 (conversion of D-glucono-1,5-lactone 6-phosphate to 6-phospho-D-gluconate) of the pathway.
human	PGLS	genes/human/PGLS/PGLS-ai-review.yaml	PGLS	O95336	NCBITaxon:9606	Homo sapiens	19	R-HSA-71296	PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate	yes	reactome/R-HSA-71296.md	PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing PGLS to the cytosol, where it catalyses the hydrolysis of D-glucono-1,5-lactone 6-phosphate. Core subcellular location.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	15	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-derived localization arising from PGM1's presence in neutrophil tertiary (secretory) granules that are exocytosed during degranulation.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	16	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-derived extracellular localization from exocytosis of ficolin-rich (granule) lumen proteins during neutrophil degranulation.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	17	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization of PGM1 to the tertiary (secretory) granule lumen of neutrophils.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	18	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome localization of PGM1 to the ficolin-1-rich granule lumen of neutrophils.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	22	R-HSA-5609939	Defective PGM1 does not isomerise G6P to G1P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (curated) cytosolic localization of PGM1, in the reaction where defective PGM1 fails to isomerise G6P to G1P.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	25	R-HSA-9638125	PGM1:Mg2+ isomerises G1P to G6P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (curated) cytosolic localization of PGM1 in the reaction where PGM1:Mg2+ isomerises G1P to G6P.
human	PGM1	genes/human/PGM1/PGM1-ai-review.yaml	PGM1	P36871	NCBITaxon:9606	Homo sapiens	26	R-HSA-9638127	PGM1:Mg2+ isomerises G6P to G1P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (curated) cytosolic localization of PGM1 in the reaction where PGM1:Mg2+ isomerises G6P to G1P (reverse direction).
human	PGM3	genes/human/PGM3/PGM3-ai-review.yaml	PGM3	O95394	NCBITaxon:9606	Homo sapiens	8	R-HSA-446210	Synthesis of UDP-N-acetyl-glucosamine	yes	reactome/R-HSA-446210.md	Synthesis of UDP-N-acetyl-glucosamine	Homo sapiens	GO:0006048	UDP-N-acetylglucosamine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) annotation to UDP-GlcNAc biosynthesis, the pathway module (Synthesis of UDP-N-acetyl-glucosamine) that includes the PGM3-catalyzed isomerization step. Correct core process; consistent with the IBA and IMP annotations to the same term.
human	PGM3	genes/human/PGM3/PGM3-ai-review.yaml	PGM3	O95394	NCBITaxon:9606	Homo sapiens	10	R-HSA-446185	Isomerization of GlcNAc6P to GlcNAc1P	yes	reactome/R-HSA-446185.md	Isomerization of GlcNAc6P to GlcNAc1P	Homo sapiens	GO:0004610	phosphoacetylglucosamine mutase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation to the core catalytic activity, corresponding to the reaction Isomerization of GlcNAc6P to GlcNAc1P. Correct and consistent with the experimental annotations of the same activity.
human	PGM3	genes/human/PGM3/PGM3-ai-review.yaml	PGM3	O95394	NCBITaxon:9606	Homo sapiens	17	R-HSA-446185	Isomerization of GlcNAc6P to GlcNAc1P	yes	reactome/R-HSA-446185.md	Isomerization of GlcNAc6P to GlcNAc1P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation localizing PGM3 to the cytosol, where the hexosamine pathway operates. Consistent with the protein's role as a soluble cytosolic metabolic enzyme and with large-scale proteomics.
human	PGRMC1	genes/human/PGRMC1/PGRMC1-ai-review.yaml	PGRMC1	O00264	NCBITaxon:9606	Homo sapiens	47	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane pool is well documented. The Reactome source (exocytosis of specific granule membrane proteins) is more about a specific pathway than the localisation itself.
human	PGRMC1	genes/human/PGRMC1/PGRMC1-ai-review.yaml	PGRMC1	O00264	NCBITaxon:9606	Homo sapiens	48	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome-derived annotation linking PGRMC1 to neutrophil specific granule membrane (exocytosis pathway). PGRMC1 has been detected in neutrophil granule-membrane proteomics but this is a niche tissue context and not functionally characterised as a core role.
human	PGRMC2	genes/human/PGRMC2/PGRMC2-ai-review.yaml	PGRMC2	O15173	NCBITaxon:9606	Homo sapiens	23	R-HSA-9707606	PGRMC2:Hemes translocate to the nucleus	yes	reactome/R-HSA-9707606.md	PGRMC2:Hemes translocate to the nucleus	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Reactome pathway shows PGRMC2:heme complex translocates to nucleus via interaction with AAAS at the NPC.
human	PGRMC2	genes/human/PGRMC2/PGRMC2-ai-review.yaml	PGRMC2	O15173	NCBITaxon:9606	Homo sapiens	24	R-HSA-9707683	PGRMC2 binds Hemes	yes	reactome/R-HSA-9707683.md	PGRMC2 binds Hemes	Homo sapiens	GO:0005635	nuclear envelope	TAS	located_in	CC	false		ACCEPT	Duplicate nuclear envelope annotation from Reactome heme binding pathway.
human	PGRMC2	genes/human/PGRMC2/PGRMC2-ai-review.yaml	PGRMC2	O15173	NCBITaxon:9606	Homo sapiens	25	R-HSA-9707606	PGRMC2:Hemes translocate to the nucleus	yes	reactome/R-HSA-9707606.md	PGRMC2:Hemes translocate to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	PGRMC2 delivers heme to the nucleus, and the heme:PGRMC2 complex may transiently enter the nucleoplasm before dissociation.
human	PGRMC2	genes/human/PGRMC2/PGRMC2-ai-review.yaml	PGRMC2	O15173	NCBITaxon:9606	Homo sapiens	26	R-HSA-9707856	PGRMC2:Hemes dissociates	yes	reactome/R-HSA-9707856.md	PGRMC2:Hemes dissociates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome heme dissociation pathway.
human	PHGDH	genes/human/PHGDH/PHGDH-ai-review.yaml	PHGDH	O43175	NCBITaxon:9606	Homo sapiens	13	R-HSA-977348	PHGDH tetramer dehydrogenates 3PG	yes	reactome/R-HSA-977348.md	PHGDH tetramer dehydrogenates 3PG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core subcellular localization. PHGDH is a soluble cytosolic enzyme catalyzing the first step of cytosolic serine biosynthesis; Reactome TAS is appropriate.
human	PHKA1	genes/human/PHKA1/PHKA1-ai-review.yaml	PHKA1	P46020	NCBITaxon:9606	Homo sapiens	11	R-HSA-71541	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	yes	reactome/R-HSA-71541.md	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) localizing PHKA1 to the cytosol as part of the cytosolic phosphorylase kinase complex.
human	PHKA2	genes/human/PHKA2/PHKA2-ai-review.yaml	PHKA2	P46019	NCBITaxon:9606	Homo sapiens	18	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization. The cytosolic phosphorylase kinase complex phosphorylates cytosolic glycogen phosphorylase (PYGL) in liver. This is the core, functionally relevant location for PHKA2.
human	PHKA2	genes/human/PHKA2/PHKA2-ai-review.yaml	PHKA2	P46019	NCBITaxon:9606	Homo sapiens	24	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005980	glycogen catabolic process	TAS	involved_in	BP	false		NEW	Proposed specific biological-process annotation: as a subunit of the cytosolic phosphorylase kinase complex, PHKA2 participates in glycogen catabolism (the complex phosphorylates glycogen phosphorylase to trigger glycogenolysis).
human	PHKB	genes/human/PHKB/PHKB-ai-review.yaml	PHKB	Q93100	NCBITaxon:9606	Homo sapiens	12	R-HSA-71541	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	yes	reactome/R-HSA-71541.md	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing PHKB in the cytosol, from the muscle phosphorylase kinase reaction (PYGM phosphorylation). Phosphorylase kinase is a cytosolic enzyme, and this is a core, accurate localization for the complex.
human	PHKB	genes/human/PHKB/PHKB-ai-review.yaml	PHKB	Q93100	NCBITaxon:9606	Homo sapiens	13	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing PHKB in the cytosol, from the liver phosphorylase kinase reaction (PYGL phosphorylation). This is the liver-variant holoenzyme (PHKA2/PHKB/PHKG2/calmodulin) in which PHKB is a shared subunit. Cytosol is a core, accurate localization for the complex.
human	PHKG2	genes/human/PHKG2/PHKG2-ai-review.yaml	PHKG2	P15735	NCBITaxon:9606	Homo sapiens	24	R-HSA-70221	Glycogen breakdown (glycogenolysis)	yes	reactome/R-HSA-70221.md	Glycogen breakdown (glycogenolysis)	Homo sapiens	GO:0005980	glycogen catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation placing PHKG2 in glycogen breakdown (glycogenolysis). Glycogen phosphorylase, activated by phosphorylase kinase, catalyzes glucose release from glycogen; PHKG2 provides the catalytic activity that switches phosphorylase on.
human	PHKG2	genes/human/PHKG2/PHKG2-ai-review.yaml	PHKG2	P15735	NCBITaxon:9606	Homo sapiens	29	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation to cytosol, where the phosphorylase kinase complex phosphorylates glycogen phosphorylase. Consistent with the HPA IDA cytosol annotation.
human	PHYKPL	genes/human/PHYKPL/PHYKPL-ai-review.yaml	PHYKPL	Q8IUZ5	NCBITaxon:9606	Homo sapiens	14	R-HSA-5696408	Reactome pathway (cached file not available)	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Original Reactome pathway reference cannot be validated due to missing cached file. However, mitochondrial matrix localization is correct based on other evidence.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	67	R-HSA-8867613	PICALM binds R-SNAREs	yes	reactome/R-HSA-8867613.md	PICALM binds R-SNAREs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	68	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	69	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	70	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	71	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	72	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	73	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	74	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	75	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	76	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	77	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	78	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	79	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	80	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	81	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICALM	genes/human/PICALM/PICALM-ai-review.yaml	PICALM	Q13492	NCBITaxon:9606	Homo sapiens	82	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This localization/process is consistent with PICALM acting at cytosolic membrane interfaces for clathrin-mediated endocytosis and vesicle trafficking.
human	PICK1	genes/human/PICK1/PICK1-ai-review.yaml	PICK1	Q9NRD5	NCBITaxon:9606	Homo sapiens	53	R-HSA-416639	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	yes	reactome/R-HSA-416639.md	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization is supported by PICK1 roles in surface receptor internalization and trafficking.
human	PICK1	genes/human/PICK1/PICK1-ai-review.yaml	PICK1	Q9NRD5	NCBITaxon:9606	Homo sapiens	54	R-HSA-416985	Trafficking of GluR2-containing AMPA receptors to synapse	yes	reactome/R-HSA-416985.md	Trafficking of GluR2-containing AMPA receptors to synapse	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization is supported by PICK1 roles in surface receptor internalization and trafficking.
human	PICK1	genes/human/PICK1/PICK1-ai-review.yaml	PICK1	Q9NRD5	NCBITaxon:9606	Homo sapiens	55	R-HSA-421007	Endocytosis of Ca impermeable AMPA receptors	yes	reactome/R-HSA-421007.md	Endocytosis of Ca impermeable AMPA receptors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization is supported by PICK1 roles in surface receptor internalization and trafficking.
human	PICK1	genes/human/PICK1/PICK1-ai-review.yaml	PICK1	Q9NRD5	NCBITaxon:9606	Homo sapiens	56	R-HSA-416639	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	yes	reactome/R-HSA-416639.md	Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Endocytic vesicle membrane localization is consistent with PICK1-mediated receptor internalization/recycling.
human	PICK1	genes/human/PICK1/PICK1-ai-review.yaml	PICK1	Q9NRD5	NCBITaxon:9606	Homo sapiens	57	R-HSA-421007	Endocytosis of Ca impermeable AMPA receptors	yes	reactome/R-HSA-421007.md	Endocytosis of Ca impermeable AMPA receptors	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Endocytic vesicle membrane localization is consistent with PICK1-mediated receptor internalization/recycling.
human	PIGA	genes/human/PIGA/PIGA-ai-review.yaml	PIGA	P37287	NCBITaxon:9606	Homo sapiens	14	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing PIGA in the GPI synthesis pathway. Matches PIGA's established role initiating GPI anchor biosynthesis.
human	PIGA	genes/human/PIGA/PIGA-ai-review.yaml	PIGA	P37287	NCBITaxon:9606	Homo sapiens	18	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0008194	UDP-glycosyltransferase activity	TAS	enables	MF	false		MODIFY	Reactome describes the reaction as using the UDP-sugar donor UDP-GlcNAc. The term correctly captures the UDP-sugar donor class but is less specific than the exact enzyme activity.
human	PIGA	genes/human/PIGA/PIGA-ai-review.yaml	PIGA	P37287	NCBITaxon:9606	Homo sapiens	20	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the GlcNAc-PI synthesis reaction (and PIGA) at the ER membrane. Consistent with direct experimental data.
human	PIGB	genes/human/PIGB/PIGB-ai-review.yaml	PIGB	Q92521	NCBITaxon:9606	Homo sapiens	6	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-traceable assertion that PIGB participates in GPI (glycosylphosphatidylinositol) synthesis; correct core biological process.
human	PIGB	genes/human/PIGB/PIGB-ai-review.yaml	PIGB	Q92521	NCBITaxon:9606	Homo sapiens	8	R-HSA-162821	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162821.md	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0004376	GPI mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-traceable assertion (the reaction adding the third mannose of the GPI anchor) that PIGB has GPI mannosyltransferase activity; a correct family-level molecular-function term for this enzyme.
human	PIGB	genes/human/PIGB/PIGB-ai-review.yaml	PIGB	Q92521	NCBITaxon:9606	Homo sapiens	10	R-HSA-162821	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162821.md	mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-traceable assertion of ER-membrane localization; consistent with the experimentally determined location.
human	PIGC	genes/human/PIGC/PIGC-ai-review.yaml	PIGC	Q92535	NCBITaxon:9606	Homo sapiens	13	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement placing the first-step GPI reaction (and its multimeric enzyme, including PIGC) in the endoplasmic reticulum membrane. Consistent with the direct experimental localization.
human	PIGF	genes/human/PIGF/PIGF-ai-review.yaml	PIGF	Q07326	NCBITaxon:9606	Homo sapiens	8	R-HSA-162742	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	yes	reactome/R-HSA-162742.md	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing PIGF (as part of the EtNP-transfer reaction converting the H6/H7 intermediate to H8) at the ER membrane.
human	PIGG	genes/human/PIGG/PIGG-ai-review.yaml	PIGG	Q5H8A4	NCBITaxon:9606	Homo sapiens	8	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion that PIGG participates in synthesis of GPI. Correct and consistent with the experimental and phylogenetic evidence.
human	PIGG	genes/human/PIGG/PIGG-ai-review.yaml	PIGG	Q5H8A4	NCBITaxon:9606	Homo sapiens	13	R-HSA-162742	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	yes	reactome/R-HSA-162742.md	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	Homo sapiens	GO:0016780	phosphotransferase activity, for other substituted phosphate groups	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome traceable assertion capturing PIGG's phosphotransferase (EtNP-transfer) reaction at a broader level. This is a correct parent of the specific mannose-ethanolamine phosphotransferase activity but is less informative than GO:0051377.
human	PIGG	genes/human/PIGG/PIGG-ai-review.yaml	PIGG	Q5H8A4	NCBITaxon:9606	Homo sapiens	15	R-HSA-162742	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	yes	reactome/R-HSA-162742.md	(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing PIGG's reaction at the ER membrane, consistent with all other localization evidence.
human	PIGH	genes/human/PIGH/PIGH-ai-review.yaml	PIGH	Q14442	NCBITaxon:9606	Homo sapiens	17	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (traceable author statement) places the GPI-GnT reaction, and hence PIGH, at the ER membrane, where the first step of GPI synthesis occurs.
human	PIGK	genes/human/PIGK/PIGK-ai-review.yaml	PIGK	Q92643	NCBITaxon:9606	Homo sapiens	16	R-HSA-162791	Attachment of GPI anchor to uPAR	yes	reactome/R-HSA-162791.md	Attachment of GPI anchor to uPAR	Homo sapiens	GO:0016255	attachment of GPI anchor to protein	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation for the GPI-T reaction attaching a GPI anchor to uPAR (a representative GPI-anchored substrate), mapped to attachment of GPI anchor to protein. Correctly represents the core BP.
human	PIGK	genes/human/PIGK/PIGK-ai-review.yaml	PIGK	Q92643	NCBITaxon:9606	Homo sapiens	39	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0003923	GPI-anchor transamidase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation for the GPI-T-catalyzed reaction (uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + propeptide), mapped to GPI-anchor transamidase activity - the exact GOA core MF term.
human	PIGK	genes/human/PIGK/PIGK-ai-review.yaml	PIGK	Q92643	NCBITaxon:9606	Homo sapiens	42	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the GPI transamidase (including PIGK) at the ER membrane, consistent with the experimental EXP annotation.
human	PIGL	genes/human/PIGL/PIGL-ai-review.yaml	PIGL	Q9Y2B2	NCBITaxon:9606	Homo sapiens	6	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation to the overall GPI synthesis pathway. Correct; PIGL catalyzes the second reaction of this ER pathway.
human	PIGL	genes/human/PIGL/PIGL-ai-review.yaml	PIGL	Q9Y2B2	NCBITaxon:9606	Homo sapiens	7	R-HSA-162857	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate	yes	reactome/R-HSA-162857.md	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate	Homo sapiens	GO:0000225	N-acetylglucosaminylphosphatidylinositol deacetylase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable annotation of the second-step deacetylase reaction (N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate) catalyzed by PIG-L. Correct core molecular function.
human	PIGL	genes/human/PIGL/PIGL-ai-review.yaml	PIGL	Q9Y2B2	NCBITaxon:9606	Homo sapiens	13	R-HSA-162857	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate	yes	reactome/R-HSA-162857.md	N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the PIG-L enzyme and its substrates in the ER membrane for the second-step reaction. Correct.
human	PIGM	genes/human/PIGM/PIGM-ai-review.yaml	PIGM	Q9H3S5	NCBITaxon:9606	Homo sapiens	18	R-HSA-162830	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162830.md	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the PIG-M/PIG-X-catalyzed first-mannose addition (step 6 of GPI synthesis) at the lumenal surface of the ER membrane. Consistent with the experimental ER-membrane localization.
human	PIGN	genes/human/PIGN/PIGN-ai-review.yaml	PIGN	O95427	NCBITaxon:9606	Homo sapiens	9	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing PIGN in the human GPI synthesis pathway. Consistent with the core biological process.
human	PIGN	genes/human/PIGN/PIGN-ai-review.yaml	PIGN	O95427	NCBITaxon:9606	Homo sapiens	15	R-HSA-162798	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol	yes	reactome/R-HSA-162798.md	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol	Homo sapiens	GO:0051377	mannose-ethanolamine phosphotransferase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation of the specific EtNP-transfer reaction catalyzed by PIGN (phosphoethanolamine from PE onto the first mannose of the GPI precursor). Directly supports the core molecular function.
human	PIGN	genes/human/PIGN/PIGN-ai-review.yaml	PIGN	O95427	NCBITaxon:9606	Homo sapiens	17	R-HSA-162798	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol	yes	reactome/R-HSA-162798.md	mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing the PIGN-catalyzed EtNP-transfer reaction in the ER. Consistent with the core localization.
human	PIGP	genes/human/PIGP/PIGP-ai-review.yaml	PIGP	P57054	NCBITaxon:9606	Homo sapiens	11	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Traceable-author (Reactome) statement placing PIGP at the endoplasmic reticulum membrane, in the reaction ""phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP"". This is the correct, specific location of the GPI-GnT complex."
human	PIGQ	genes/human/PIGQ/PIGQ-ai-review.yaml	PIGQ	Q9BRB3	NCBITaxon:9606	Homo sapiens	14	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome localizing the GlcNAc-PI-forming reaction and its catalysing multimeric enzyme to the ER membrane. Concordant with the IDA ER-membrane annotation; core location.
human	PIGS	genes/human/PIGS/PIGS-ai-review.yaml	PIGS	Q96S52	NCBITaxon:9606	Homo sapiens	34	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author-statement (Reactome) localization to the ER membrane, in the context of GPI-anchor attachment reactions. Correct and consistent with all other evidence.
human	PIGT	genes/human/PIGT/PIGT-ai-review.yaml	PIGT	Q969N2	NCBITaxon:9606	Homo sapiens	40	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) annotation to the ER membrane, from the uPAR GPI-attachment reaction catalysed by the ER-membrane GPI transamidase complex.
human	PIGU	genes/human/PIGU/PIGU-ai-review.yaml	PIGU	Q9H490	NCBITaxon:9606	Homo sapiens	28	R-HSA-162836	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	yes	reactome/R-HSA-162836.md	uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement annotation placing PIGU in the ER membrane in the context of the GPI-anchor attachment reaction. Consistent with the established localization.
human	PIGV	genes/human/PIGV/PIGV-ai-review.yaml	PIGV	Q9NUD9	NCBITaxon:9606	Homo sapiens	10	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of PIGV in the human GPI synthesis pathway (Synthesis of glycosylphosphatidylinositol). Correct core biological process.
human	PIGV	genes/human/PIGV/PIGV-ai-review.yaml	PIGV	Q9NUD9	NCBITaxon:9606	Homo sapiens	12	R-HSA-162873	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162873.md	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0004376	GPI mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of GPI mannosyltransferase activity to PIGV for the second-mannose-addition reaction. Correct parent of the specific GPI-MT-II activity (GO:0120563).
human	PIGV	genes/human/PIGV/PIGV-ai-review.yaml	PIGV	Q9NUD9	NCBITaxon:9606	Homo sapiens	16	R-HSA-162873	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162873.md	(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of the second-mannose-addition reaction (and PIGV) to the ER membrane, consistent with PIGV being a multi-pass ER membrane enzyme acting on the lumenal face.
human	PIGW	genes/human/PIGW/PIGW-ai-review.yaml	PIGW	Q7Z7B1	NCBITaxon:9606	Homo sapiens	10	R-HSA-162710	Synthesis of glycosylphosphatidylinositol (GPI)	yes	reactome/R-HSA-162710.md	Synthesis of glycosylphosphatidylinositol (GPI)	Homo sapiens	GO:0006506	GPI anchor biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-traceable annotation to the core biosynthetic process, from the human GPI synthesis pathway (R-HSA-162710), in which PIGW catalyses the inositol-acylation step.
human	PIGW	genes/human/PIGW/PIGW-ai-review.yaml	PIGW	Q7Z7B1	NCBITaxon:9606	Homo sapiens	14	R-HSA-162683	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH	yes	reactome/R-HSA-162683.md	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH	Homo sapiens	GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome-traceable annotation to a broad acyltransferase-class term for the inositol-acylation reaction (R-HSA-162683). This is a general parent of the specific MF GO:0032216.
human	PIGW	genes/human/PIGW/PIGW-ai-review.yaml	PIGW	Q7Z7B1	NCBITaxon:9606	Homo sapiens	17	R-HSA-162683	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH	yes	reactome/R-HSA-162683.md	glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-traceable ER membrane localisation for the inositol-acylation reaction, consistent with the multi-pass ER membrane topology. Duplicate of the accepted core CC term.
human	PIGX	genes/human/PIGX/PIGX-ai-review.yaml	PIGX	Q8TBF5	NCBITaxon:9606	Homo sapiens	6	R-HSA-162830	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate	yes	reactome/R-HSA-162830.md	glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the PIG-M/PIG-X-catalyzed addition of the first mannose to glucosaminyl-acyl-PI at the lumenal surface of the ER membrane. Consistent with all other ER-membrane annotations for PIGX.
human	PIGY	genes/human/PIGY/PIGY-ai-review.yaml	PIGY	Q3MUY2	NCBITaxon:9606	Homo sapiens	10	R-HSA-162730	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	yes	reactome/R-HSA-162730.md	phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) localising the GlcNAc-PI-forming reaction and its catalysing complex, including PIGY, to the ER membrane.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	69	R-HSA-1632852	Macroautophagy	yes	reactome/R-HSA-1632852.md	Macroautophagy	Homo sapiens	GO:0016236	macroautophagy	TAS	involved_in	BP	false		ACCEPT	Macroautophagy is a core PIK3C3 process.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	70	R-HSA-5672012	Beclin-1 complex phosphorylates PtdIns	yes	reactome/R-HSA-5672012.md	Beclin-1 complex phosphorylates PtdIns	Homo sapiens	GO:0016303	1-phosphatidylinositol-3-kinase activity	TAS	enables	MF	false		ACCEPT	The Reactome TAS row correctly captures the core VPS34 lipid kinase activity.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	71	R-HSA-6798174	PIK3C3:PIK3R4 phosphorylates PI to PI3P	yes	reactome/R-HSA-6798174.md	PIK3C3:PIK3R4 phosphorylates PI to PI3P	Homo sapiens	GO:0016303	1-phosphatidylinositol-3-kinase activity	TAS	enables	MF	false		ACCEPT	The Reactome TAS row correctly captures the core VPS34 lipid kinase activity.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	89	R-HSA-6798174	PIK3C3:PIK3R4 phosphorylates PI to PI3P	yes	reactome/R-HSA-6798174.md	PIK3C3:PIK3R4 phosphorylates PI to PI3P	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Phagocytic vesicle membrane is a supported but non-core trafficking context.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	101	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	102	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	103	R-HSA-1675939	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane	yes	reactome/R-HSA-1675939.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	104	R-HSA-1675961	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane	yes	reactome/R-HSA-1675961.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	105	R-HSA-1676024	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane	yes	reactome/R-HSA-1676024.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	106	R-HSA-188002	Rab5-mediated recruitment of class III PI3K to TLR9	yes	reactome/R-HSA-188002.md	Rab5-mediated recruitment of class III PI3K to TLR9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	107	R-HSA-5672012	Beclin-1 complex phosphorylates PtdIns	yes	reactome/R-HSA-5672012.md	Beclin-1 complex phosphorylates PtdIns	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	108	R-HSA-5678313	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	yes	reactome/R-HSA-5678313.md	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	109	R-HSA-5678315	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	yes	reactome/R-HSA-5678315.md	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	110	R-HSA-5679205	ULK1 phosphorylates Beclin-1	yes	reactome/R-HSA-5679205.md	ULK1 phosphorylates Beclin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	111	R-HSA-5679266	Beclin-1 complex translocates to the ER	yes	reactome/R-HSA-5679266.md	Beclin-1 complex translocates to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	112	R-HSA-5682385	The phagophore extends from the PIP3-enriched structure	yes	reactome/R-HSA-5682385.md	The phagophore extends from the PIP3-enriched structure	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	113	R-HSA-9755359	SARS-CoV-2 8:class I MHC binds BECN1	yes	reactome/R-HSA-9755359.md	SARS-CoV-2 8:class I MHC binds BECN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3C3	genes/human/PIK3C3/PIK3C3-ai-review.yaml	PIK3C3	Q8NEB9	NCBITaxon:9606	Homo sapiens	114	R-HSA-9921171	NS1 binds Beclin-1	yes	reactome/R-HSA-9921171.md	NS1 binds Beclin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a broad Reactome component assignment for PIK3C3 pathway events.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	54	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	55	R-HSA-114542	RAC1,RAC2,RHOG activate PI3K	yes	reactome/R-HSA-114542.md	RAC1,RAC2,RHOG activate PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	56	R-HSA-1226012	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226012.md	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	57	R-HSA-1226014	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	yes	reactome/R-HSA-1226014.md	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	58	R-HSA-1250189	Binding of PI3K to ERBB2:p-ERBB3 heterodimer	yes	reactome/R-HSA-1250189.md	Binding of PI3K to ERBB2:p-ERBB3 heterodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	59	R-HSA-1250346	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers	yes	reactome/R-HSA-1250346.md	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	60	R-HSA-1250353	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers	yes	reactome/R-HSA-1250353.md	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	61	R-HSA-1250370	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers	yes	reactome/R-HSA-1250370.md	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	62	R-HSA-1250462	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3	yes	reactome/R-HSA-1250462.md	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	63	R-HSA-1306957	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306957.md	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	64	R-HSA-1306965	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	yes	reactome/R-HSA-1306965.md	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	65	R-HSA-1306979	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1	yes	reactome/R-HSA-1306979.md	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	66	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	67	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	68	R-HSA-1676048	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane	yes	reactome/R-HSA-1676048.md	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	69	R-HSA-1676109	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane	yes	reactome/R-HSA-1676109.md	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	70	R-HSA-177927	PI3K binds to EGF:EGFR:GRB2:GAB1	yes	reactome/R-HSA-177927.md	PI3K binds to EGF:EGFR:GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	71	R-HSA-177939	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	yes	reactome/R-HSA-177939.md	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	72	R-HSA-1839080	Activated cytosolic FGFR1 fusions bind PIK3CA	yes	reactome/R-HSA-1839080.md	Activated cytosolic FGFR1 fusions bind PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	73	R-HSA-1839091	Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-1839091.md	Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	74	R-HSA-1839102	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-1839102.md	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	75	R-HSA-1839107	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-1839107.md	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	76	R-HSA-186780	PI3-kinase binds to the active receptor	yes	reactome/R-HSA-186780.md	PI3-kinase binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	77	R-HSA-186800	PI3K catalyses the phosphorylation of PIP2 to PIP3	yes	reactome/R-HSA-186800.md	PI3K catalyses the phosphorylation of PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	78	R-HSA-198266	PI3K produces PIP3 and other phosphatidyl inositides	yes	reactome/R-HSA-198266.md	PI3K produces PIP3 and other phosphatidyl inositides	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	79	R-HSA-198315	Active IRS recruits PI3K to the plasma membrane and activates it	yes	reactome/R-HSA-198315.md	Active IRS recruits PI3K to the plasma membrane and activates it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	80	R-HSA-201510	PI3K synthesizes PIP3 downstream of ALK	yes	reactome/R-HSA-201510.md	PI3K synthesizes PIP3 downstream of ALK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	81	R-HSA-201515	Active ALK recruits PI3K	yes	reactome/R-HSA-201515.md	Active ALK recruits PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	82	R-HSA-202203	Recruitment of PI3K to plasma membrane	yes	reactome/R-HSA-202203.md	Recruitment of PI3K to plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	83	R-HSA-202365	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-202365.md	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	84	R-HSA-2029271	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2029271.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	85	R-HSA-2029273	PI3K binds to p-6Y-SYK	yes	reactome/R-HSA-2029273.md	PI3K binds to p-6Y-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	86	R-HSA-204798	Interaction of Tie2 and p85 of PI3K	yes	reactome/R-HSA-204798.md	Interaction of Tie2 and p85 of PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	87	R-HSA-205262	Direct recruitment of PI3K to p-KIT	yes	reactome/R-HSA-205262.md	Direct recruitment of PI3K to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	88	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	89	R-HSA-2394007	PI3K gain of function mutants phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-2394007.md	PI3K gain of function mutants phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	90	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	91	R-HSA-2424480	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2424480.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	92	R-HSA-2424482	p85 regulatory unit of PI3K binds p-6Y-SYK	yes	reactome/R-HSA-2424482.md	p85 regulatory unit of PI3K binds p-6Y-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	93	R-HSA-2730842	PI3K associates with phosphorylated GAB2	yes	reactome/R-HSA-2730842.md	PI3K associates with phosphorylated GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	94	R-HSA-2730870	Phosphorylation of PIP2 to PIP3 by PI3K	yes	reactome/R-HSA-2730870.md	Phosphorylation of PIP2 to PIP3 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	95	R-HSA-416358	G alpha (q) inhibits PI3K alpha	yes	reactome/R-HSA-416358.md	G alpha (q) inhibits PI3K alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	96	R-HSA-437162	PI3K alpha, beta, gamma convert PIP2 to PIP3	yes	reactome/R-HSA-437162.md	PI3K alpha, beta, gamma convert PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	97	R-HSA-508247	Gab2 binds the p85 subunit of Class 1A PI3 kinases	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	98	R-HSA-5218819	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5218819.md	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	99	R-HSA-5357479	p-AXL binds PI3K	yes	reactome/R-HSA-5357479.md	p-AXL binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	100	R-HSA-5637765	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	yes	reactome/R-HSA-5637765.md	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	101	R-HSA-5637801	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637801.md	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	102	R-HSA-5654591	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654591.md	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	103	R-HSA-5654596	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654596.md	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	104	R-HSA-5654614	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654614.md	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	105	R-HSA-5654622	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	106	R-HSA-5654640	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654640.md	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	107	R-HSA-5654643	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654643.md	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	108	R-HSA-5654662	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	yes	reactome/R-HSA-5654662.md	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	109	R-HSA-5654669	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	110	R-HSA-5654690	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654690.md	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	111	R-HSA-5654692	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654692.md	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	112	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	113	R-HSA-5654701	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654701.md	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	114	R-HSA-5654705	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654705.md	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	115	R-HSA-5654709	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654709.md	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	116	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	117	R-HSA-5654717	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654717.md	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	118	R-HSA-5655235	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655235.md	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	119	R-HSA-5655245	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655245.md	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	120	R-HSA-5655252	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655252.md	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	121	R-HSA-5655263	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655263.md	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	122	R-HSA-5655285	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5655285.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	123	R-HSA-5655289	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655289.md	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	124	R-HSA-5655290	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	125	R-HSA-5655323	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	126	R-HSA-74737	p-Y-IRS1,p-Y-IRS2 bind PI3K	yes	reactome/R-HSA-74737.md	p-Y-IRS1,p-Y-IRS2 bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	127	R-HSA-879917	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	yes	reactome/R-HSA-879917.md	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	128	R-HSA-8851954	Phosphorylated GAB1 recruits PI3K to MET	yes	reactome/R-HSA-8851954.md	Phosphorylated GAB1 recruits PI3K to MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	129	R-HSA-8852019	MET bound PI3K generates PIP3	yes	reactome/R-HSA-8852019.md	MET bound PI3K generates PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	130	R-HSA-8854905	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	yes	reactome/R-HSA-8854905.md	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	131	R-HSA-9012657	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	yes	reactome/R-HSA-9012657.md	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	132	R-HSA-9013145	RAC1 binds effectors at the plasma membrane	yes	reactome/R-HSA-9013145.md	RAC1 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	133	R-HSA-9014294	RAC2 binds effectors at the plasma membrane	yes	reactome/R-HSA-9014294.md	RAC2 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	134	R-HSA-9021627	EPOR-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-9021627.md	EPOR-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	135	R-HSA-9021660	PI3K binds membrane-associated estrogen receptors	yes	reactome/R-HSA-9021660.md	PI3K binds membrane-associated estrogen receptors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	136	R-HSA-9027275	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	yes	reactome/R-HSA-9027275.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	137	R-HSA-912627	CBL ubiquitinates PI3K	yes	reactome/R-HSA-912627.md	CBL ubiquitinates PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	138	R-HSA-914182	14-3-3 zeta binding allows recruitment of PI3K	yes	reactome/R-HSA-914182.md	14-3-3 zeta binding allows recruitment of PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	139	R-HSA-9632412	PTK2 is recruited to methylated ESR1	yes	reactome/R-HSA-9632412.md	PTK2 is recruited to methylated ESR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	140	R-HSA-9658253	RAS:GTP binds PI3K	yes	reactome/R-HSA-9658253.md	RAS:GTP binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	141	R-HSA-9664646	Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K	yes	reactome/R-HSA-9664646.md	Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	142	R-HSA-9664664	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3	yes	reactome/R-HSA-9664664.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	143	R-HSA-9664933	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9664933.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	144	R-HSA-9664940	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9664940.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	145	R-HSA-9665407	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	yes	reactome/R-HSA-9665407.md	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	146	R-HSA-9665415	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	yes	reactome/R-HSA-9665415.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	147	R-HSA-9670431	Phosphorylated KIT mutants bind PI3K	yes	reactome/R-HSA-9670431.md	Phosphorylated KIT mutants bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	148	R-HSA-9670433	KIT mutants:PI3K catalyze synthesis of PIP3	yes	reactome/R-HSA-9670433.md	KIT mutants:PI3K catalyze synthesis of PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	149	R-HSA-9672162	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672162.md	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	150	R-HSA-9672172	PI3-kinase binds to mutant PDGFR receptor	yes	reactome/R-HSA-9672172.md	PI3-kinase binds to mutant PDGFR receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	151	R-HSA-9672177	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR	yes	reactome/R-HSA-9672177.md	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	152	R-HSA-9672178	PI3-kinase binds to PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672178.md	PI3-kinase binds to PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	153	R-HSA-9698170	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-9698170.md	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	154	R-HSA-9698174	FLT3 mutants recruit PIK3CA through PIK3R1	yes	reactome/R-HSA-9698174.md	FLT3 mutants recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	155	R-HSA-9703434	FLT3 fusions recruit PIK3CA through PIK3R1	yes	reactome/R-HSA-9703434.md	FLT3 fusions recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	156	R-HSA-9706345	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-9706345.md	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	157	R-HSA-9712083	ALK mutants bind PI3KCA	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	158	R-HSA-9712084	PI3K synthesizes PIP3 downstream of ALK mutants	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	159	R-HSA-9842649	Active LTK receptor binds PI3K	yes	reactome/R-HSA-9842649.md	Active LTK receptor binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	160	R-HSA-9845032	CLIP1-LTK fusion binds PI3K to activate AKT	yes	reactome/R-HSA-9845032.md	CLIP1-LTK fusion binds PI3K to activate AKT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p110alpha resides in the cytosol as the inactive heterodimer prior to membrane recruitment; captured across many Reactome PI3K reactions.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	170	R-HSA-177929	Signaling by EGFR	yes	reactome/R-HSA-177929.md	Signaling by EGFR	Homo sapiens	GO:0007173	epidermal growth factor receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	p110alpha is recruited downstream of activated EGFR to generate PIP3.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	219	R-HSA-177939	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	yes	reactome/R-HSA-177939.md	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	220	R-HSA-1839107	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-1839107.md	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	221	R-HSA-186800	PI3K catalyses the phosphorylation of PIP2 to PIP3	yes	reactome/R-HSA-186800.md	PI3K catalyses the phosphorylation of PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	222	R-HSA-201510	PI3K synthesizes PIP3 downstream of ALK	yes	reactome/R-HSA-201510.md	PI3K synthesizes PIP3 downstream of ALK	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	223	R-HSA-202365	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-202365.md	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	224	R-HSA-5655235	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655235.md	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	225	R-HSA-5655289	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655289.md	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	226	R-HSA-5655290	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	227	R-HSA-5655323	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	As the catalytic p110alpha subunit of class IA PI3K, PIK3CA phosphorylates the 3-position of PI(4,5)P2 using ATP to generate the second messenger PIP3; this is its primary molecular function.
human	PIK3CA	genes/human/PIK3CA/PIK3CA-ai-review.yaml	PIK3CA	P42336	NCBITaxon:9606	Homo sapiens	232	R-HSA-202403	TCR signaling	yes	reactome/R-HSA-202403.md	TCR signaling	Homo sapiens	GO:0050852	T cell receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	PI3K acts downstream of the T cell receptor.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	50	R-HSA-389356	Co-stimulation by CD28	yes	reactome/R-HSA-389356.md	Co-stimulation by CD28	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		ACCEPT	Supported CD28/T-cell costimulation context for PI3Kdelta signaling.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	51	R-HSA-389158	CD28 bound PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-389158.md	CD28 bound PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0046934	1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	TAS	enables	MF	false		ACCEPT	Core specific molecular function: p110delta phosphorylates PI(4,5)P2 to generate PIP3.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	89	R-HSA-1676048	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane	yes	reactome/R-HSA-1676048.md	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	90	R-HSA-1676109	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane	yes	reactome/R-HSA-1676109.md	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	91	R-HSA-9012657	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	yes	reactome/R-HSA-9012657.md	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	92	R-HSA-9021627	EPOR-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-9021627.md	EPOR-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	93	R-HSA-9027275	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	yes	reactome/R-HSA-9027275.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	94	R-HSA-9606887	p-CD19:VAV binds PI3K and GRB2	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported cytoplasmic or cytosolic localization, but this is the resting/general pool rather than the most informative activated signaling site.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	95	R-HSA-2045911	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	yes	reactome/R-HSA-2045911.md	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	96	R-HSA-2076220	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	yes	reactome/R-HSA-2076220.md	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	97	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	98	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	99	R-HSA-388830	PI3K binds ICOS	yes	reactome/R-HSA-388830.md	PI3K binds ICOS	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	100	R-HSA-388832	PI3K binds CD28	yes	reactome/R-HSA-388832.md	PI3K binds CD28	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	101	R-HSA-389158	CD28 bound PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-389158.md	CD28 bound PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	102	R-HSA-508247	Gab2 binds the p85 subunit of Class 1A PI3 kinases	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	103	R-HSA-879917	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	yes	reactome/R-HSA-879917.md	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	104	R-HSA-8854905	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	yes	reactome/R-HSA-8854905.md	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	105	R-HSA-912627	CBL ubiquitinates PI3K	yes	reactome/R-HSA-912627.md	CBL ubiquitinates PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	106	R-HSA-914182	14-3-3 zeta binding allows recruitment of PI3K	yes	reactome/R-HSA-914182.md	14-3-3 zeta binding allows recruitment of PI3K	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3CD	genes/human/PIK3CD/PIK3CD-ai-review.yaml	PIK3CD	O00329	NCBITaxon:9606	Homo sapiens	107	R-HSA-9606887	p-CD19:VAV binds PI3K and GRB2	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core activated-site localization. PI3Kdelta is recruited to plasma-membrane receptor/adaptor complexes where its phosphoinositide substrates reside.
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	198	R-HSA-109699	Reactome pathway/reaction R-HSA-109699	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	199	R-HSA-114542	Reactome pathway/reaction R-HSA-114542	yes	reactome/R-HSA-114542.md	RAC1,RAC2,RHOG activate PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	200	R-HSA-1226012	Reactome pathway/reaction R-HSA-1226012	yes	reactome/R-HSA-1226012.md	Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	201	R-HSA-1226014	Reactome pathway/reaction R-HSA-1226014	yes	reactome/R-HSA-1226014.md	Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	202	R-HSA-1250189	Reactome pathway/reaction R-HSA-1250189	yes	reactome/R-HSA-1250189.md	Binding of PI3K to ERBB2:p-ERBB3 heterodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	203	R-HSA-1250346	Reactome pathway/reaction R-HSA-1250346	yes	reactome/R-HSA-1250346.md	Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	204	R-HSA-1250353	Reactome pathway/reaction R-HSA-1250353	yes	reactome/R-HSA-1250353.md	Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	205	R-HSA-1250370	Reactome pathway/reaction R-HSA-1250370	yes	reactome/R-HSA-1250370.md	Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	206	R-HSA-1306965	Reactome pathway/reaction R-HSA-1306965	yes	reactome/R-HSA-1306965.md	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	207	R-HSA-1306979	Reactome pathway/reaction R-HSA-1306979	yes	reactome/R-HSA-1306979.md	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	208	R-HSA-1433514	Reactome pathway/reaction R-HSA-1433514	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	209	R-HSA-1562641	Reactome pathway/reaction R-HSA-1562641	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	210	R-HSA-1676048	Reactome pathway/reaction R-HSA-1676048	yes	reactome/R-HSA-1676048.md	PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	211	R-HSA-1676109	Reactome pathway/reaction R-HSA-1676109	yes	reactome/R-HSA-1676109.md	PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	212	R-HSA-177927	Reactome pathway/reaction R-HSA-177927	yes	reactome/R-HSA-177927.md	PI3K binds to EGF:EGFR:GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	213	R-HSA-177931	Reactome pathway/reaction R-HSA-177931	yes	reactome/R-HSA-177931.md	Binding of PIK3 regulatory alpha subunit to GRB2:GAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	214	R-HSA-177939	Reactome pathway/reaction R-HSA-177939	yes	reactome/R-HSA-177939.md	PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	215	R-HSA-1839078	Reactome pathway/reaction R-HSA-1839078	yes	reactome/R-HSA-1839078.md	Cytosolic FGFR1 fusion proteins bind PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	216	R-HSA-1839080	Reactome pathway/reaction R-HSA-1839080	yes	reactome/R-HSA-1839080.md	Activated cytosolic FGFR1 fusions bind PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	217	R-HSA-1839091	Reactome pathway/reaction R-HSA-1839091	yes	reactome/R-HSA-1839091.md	Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	218	R-HSA-1839102	Reactome pathway/reaction R-HSA-1839102	yes	reactome/R-HSA-1839102.md	BCR-FGFR1 fusion:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	219	R-HSA-1839107	Reactome pathway/reaction R-HSA-1839107	yes	reactome/R-HSA-1839107.md	BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	220	R-HSA-1839114	Reactome pathway/reaction R-HSA-1839114	yes	reactome/R-HSA-1839114.md	BCR-FGFR1:GRB2:p-GAB2 binds PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	221	R-HSA-186780	Reactome pathway/reaction R-HSA-186780	yes	reactome/R-HSA-186780.md	PI3-kinase binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	222	R-HSA-186800	Reactome pathway/reaction R-HSA-186800	yes	reactome/R-HSA-186800.md	PI3K catalyses the phosphorylation of PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	223	R-HSA-198266	Reactome pathway/reaction R-HSA-198266	yes	reactome/R-HSA-198266.md	PI3K produces PIP3 and other phosphatidyl inositides	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	224	R-HSA-198315	Reactome pathway/reaction R-HSA-198315	yes	reactome/R-HSA-198315.md	Active IRS recruits PI3K to the plasma membrane and activates it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	225	R-HSA-201510	Reactome pathway/reaction R-HSA-201510	yes	reactome/R-HSA-201510.md	PI3K synthesizes PIP3 downstream of ALK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	226	R-HSA-201515	Reactome pathway/reaction R-HSA-201515	yes	reactome/R-HSA-201515.md	Active ALK recruits PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	227	R-HSA-202203	Reactome pathway/reaction R-HSA-202203	yes	reactome/R-HSA-202203.md	Recruitment of PI3K to plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	228	R-HSA-202365	Reactome pathway/reaction R-HSA-202365	yes	reactome/R-HSA-202365.md	PI3K bound to TRAT1 phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	229	R-HSA-2029271	Reactome pathway/reaction R-HSA-2029271	yes	reactome/R-HSA-2029271.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	230	R-HSA-2029273	Reactome pathway/reaction R-HSA-2029273	yes	reactome/R-HSA-2029273.md	PI3K binds to p-6Y-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	231	R-HSA-204798	Reactome pathway/reaction R-HSA-204798	yes	reactome/R-HSA-204798.md	Interaction of Tie2 and p85 of PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	232	R-HSA-205262	Reactome pathway/reaction R-HSA-205262	yes	reactome/R-HSA-205262.md	Direct recruitment of PI3K to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	233	R-HSA-2316434	Reactome pathway/reaction R-HSA-2316434	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	234	R-HSA-2400009	Reactome pathway/reaction R-HSA-2400009	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	235	R-HSA-2424480	Reactome pathway/reaction R-HSA-2424480	yes	reactome/R-HSA-2424480.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	236	R-HSA-2424482	Reactome pathway/reaction R-HSA-2424482	yes	reactome/R-HSA-2424482.md	p85 regulatory unit of PI3K binds p-6Y-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	237	R-HSA-2730842	Reactome pathway/reaction R-HSA-2730842	yes	reactome/R-HSA-2730842.md	PI3K associates with phosphorylated GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	238	R-HSA-2730870	Reactome pathway/reaction R-HSA-2730870	yes	reactome/R-HSA-2730870.md	Phosphorylation of PIP2 to PIP3 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	239	R-HSA-388830	Reactome pathway/reaction R-HSA-388830	yes	reactome/R-HSA-388830.md	PI3K binds ICOS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	240	R-HSA-388832	Reactome pathway/reaction R-HSA-388832	yes	reactome/R-HSA-388832.md	PI3K binds CD28	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	241	R-HSA-389158	Reactome pathway/reaction R-HSA-389158	yes	reactome/R-HSA-389158.md	CD28 bound PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	242	R-HSA-416358	Reactome pathway/reaction R-HSA-416358	yes	reactome/R-HSA-416358.md	G alpha (q) inhibits PI3K alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	243	R-HSA-437118	Reactome pathway/reaction R-HSA-437118	yes	reactome/R-HSA-437118.md	GPVI stimulates PI3K beta, gamma	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	244	R-HSA-437162	Reactome pathway/reaction R-HSA-437162	yes	reactome/R-HSA-437162.md	PI3K alpha, beta, gamma convert PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	245	R-HSA-443402	Reactome pathway/reaction R-HSA-443402	yes	reactome/R-HSA-443402.md	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	246	R-HSA-508247	Reactome pathway/reaction R-HSA-508247	yes	reactome/R-HSA-508247.md	Gab2 binds the p85 subunit of Class 1A PI3 kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	247	R-HSA-5218819	Reactome pathway/reaction R-HSA-5218819	yes	reactome/R-HSA-5218819.md	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	248	R-HSA-5357479	Reactome pathway/reaction R-HSA-5357479	yes	reactome/R-HSA-5357479.md	p-AXL binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	249	R-HSA-5637765	Reactome pathway/reaction R-HSA-5637765	yes	reactome/R-HSA-5637765.md	Binding of PI3K to complex of GRB2:GAB1 and p-EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	250	R-HSA-5637801	Reactome pathway/reaction R-HSA-5637801	yes	reactome/R-HSA-5637801.md	Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	251	R-HSA-5654591	Reactome pathway/reaction R-HSA-5654591	yes	reactome/R-HSA-5654591.md	Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	252	R-HSA-5654592	Reactome pathway/reaction R-HSA-5654592	yes	reactome/R-HSA-5654592.md	Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	253	R-HSA-5654594	Reactome pathway/reaction R-HSA-5654594	yes	reactome/R-HSA-5654594.md	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	254	R-HSA-5654596	Reactome pathway/reaction R-HSA-5654596	yes	reactome/R-HSA-5654596.md	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	255	R-HSA-5654612	Reactome pathway/reaction R-HSA-5654612	yes	reactome/R-HSA-5654612.md	Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	256	R-HSA-5654614	Reactome pathway/reaction R-HSA-5654614	yes	reactome/R-HSA-5654614.md	Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	257	R-HSA-5654620	Reactome pathway/reaction R-HSA-5654620	yes	reactome/R-HSA-5654620.md	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	258	R-HSA-5654622	Reactome pathway/reaction R-HSA-5654622	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	259	R-HSA-5654637	Reactome pathway/reaction R-HSA-5654637	yes	reactome/R-HSA-5654637.md	Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	260	R-HSA-5654640	Reactome pathway/reaction R-HSA-5654640	yes	reactome/R-HSA-5654640.md	Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	261	R-HSA-5654641	Reactome pathway/reaction R-HSA-5654641	yes	reactome/R-HSA-5654641.md	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	262	R-HSA-5654643	Reactome pathway/reaction R-HSA-5654643	yes	reactome/R-HSA-5654643.md	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	263	R-HSA-5654659	Reactome pathway/reaction R-HSA-5654659	yes	reactome/R-HSA-5654659.md	Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	264	R-HSA-5654662	Reactome pathway/reaction R-HSA-5654662	yes	reactome/R-HSA-5654662.md	Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	265	R-HSA-5654667	Reactome pathway/reaction R-HSA-5654667	yes	reactome/R-HSA-5654667.md	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	266	R-HSA-5654669	Reactome pathway/reaction R-HSA-5654669	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	267	R-HSA-5654690	Reactome pathway/reaction R-HSA-5654690	yes	reactome/R-HSA-5654690.md	FGFR1-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	268	R-HSA-5654692	Reactome pathway/reaction R-HSA-5654692	yes	reactome/R-HSA-5654692.md	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	269	R-HSA-5654697	Reactome pathway/reaction R-HSA-5654697	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	270	R-HSA-5654701	Reactome pathway/reaction R-HSA-5654701	yes	reactome/R-HSA-5654701.md	FGFR2-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	271	R-HSA-5654705	Reactome pathway/reaction R-HSA-5654705	yes	reactome/R-HSA-5654705.md	FGFR3-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	272	R-HSA-5654709	Reactome pathway/reaction R-HSA-5654709	yes	reactome/R-HSA-5654709.md	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	273	R-HSA-5654714	Reactome pathway/reaction R-HSA-5654714	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	274	R-HSA-5654717	Reactome pathway/reaction R-HSA-5654717	yes	reactome/R-HSA-5654717.md	FGFR4-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	275	R-HSA-5655235	Reactome pathway/reaction R-HSA-5655235	yes	reactome/R-HSA-5655235.md	Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	276	R-HSA-5655240	Reactome pathway/reaction R-HSA-5655240	yes	reactome/R-HSA-5655240.md	Activated FGFR1 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	277	R-HSA-5655245	Reactome pathway/reaction R-HSA-5655245	yes	reactome/R-HSA-5655245.md	Activated FGFR2 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	278	R-HSA-5655248	Reactome pathway/reaction R-HSA-5655248	yes	reactome/R-HSA-5655248.md	Activated FGFR4 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	279	R-HSA-5655252	Reactome pathway/reaction R-HSA-5655252	yes	reactome/R-HSA-5655252.md	Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	280	R-HSA-5655263	Reactome pathway/reaction R-HSA-5655263	yes	reactome/R-HSA-5655263.md	Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	281	R-HSA-5655285	Reactome pathway/reaction R-HSA-5655285	yes	reactome/R-HSA-5655285.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	282	R-HSA-5655289	Reactome pathway/reaction R-HSA-5655289	yes	reactome/R-HSA-5655289.md	Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	283	R-HSA-5655290	Reactome pathway/reaction R-HSA-5655290	yes	reactome/R-HSA-5655290.md	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	284	R-HSA-5655315	Reactome pathway/reaction R-HSA-5655315	yes	reactome/R-HSA-5655315.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	285	R-HSA-5655320	Reactome pathway/reaction R-HSA-5655320	yes	reactome/R-HSA-5655320.md	Activated FGFR2 mutants:p-FRS2 binds GRB2:GAB1:PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	286	R-HSA-5655323	Reactome pathway/reaction R-HSA-5655323	yes	reactome/R-HSA-5655323.md	Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	287	R-HSA-6790041	Reactome pathway/reaction R-HSA-6790041	yes	reactome/R-HSA-6790041.md	Expression of STAT3-upregulated cytosolic proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	288	R-HSA-74737	Reactome pathway/reaction R-HSA-74737	yes	reactome/R-HSA-74737.md	p-Y-IRS1,p-Y-IRS2 bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	289	R-HSA-879917	Reactome pathway/reaction R-HSA-879917	yes	reactome/R-HSA-879917.md	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	290	R-HSA-8851954	Reactome pathway/reaction R-HSA-8851954	yes	reactome/R-HSA-8851954.md	Phosphorylated GAB1 recruits PI3K to MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	291	R-HSA-8852019	Reactome pathway/reaction R-HSA-8852019	yes	reactome/R-HSA-8852019.md	MET bound PI3K generates PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	292	R-HSA-8854905	Reactome pathway/reaction R-HSA-8854905	yes	reactome/R-HSA-8854905.md	p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	293	R-HSA-9012657	Reactome pathway/reaction R-HSA-9012657	yes	reactome/R-HSA-9012657.md	EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	294	R-HSA-9013145	Reactome pathway/reaction R-HSA-9013145	yes	reactome/R-HSA-9013145.md	RAC1 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	295	R-HSA-9014294	Reactome pathway/reaction R-HSA-9014294	yes	reactome/R-HSA-9014294.md	RAC2 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	296	R-HSA-9018766	Reactome pathway/reaction R-HSA-9018766	yes	reactome/R-HSA-9018766.md	RHOU binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	297	R-HSA-9021627	Reactome pathway/reaction R-HSA-9021627	yes	reactome/R-HSA-9021627.md	EPOR-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	298	R-HSA-9021660	Reactome pathway/reaction R-HSA-9021660	yes	reactome/R-HSA-9021660.md	PI3K binds membrane-associated estrogen receptors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	299	R-HSA-9027275	Reactome pathway/reaction R-HSA-9027275	yes	reactome/R-HSA-9027275.md	EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	300	R-HSA-912627	Reactome pathway/reaction R-HSA-912627	yes	reactome/R-HSA-912627.md	CBL ubiquitinates PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	301	R-HSA-914182	Reactome pathway/reaction R-HSA-914182	yes	reactome/R-HSA-914182.md	14-3-3 zeta binding allows recruitment of PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	302	R-HSA-9606887	Reactome pathway/reaction R-HSA-9606887	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	303	R-HSA-9632412	Reactome pathway/reaction R-HSA-9632412	yes	reactome/R-HSA-9632412.md	PTK2 is recruited to methylated ESR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	304	R-HSA-9658253	Reactome pathway/reaction R-HSA-9658253	yes	reactome/R-HSA-9658253.md	RAS:GTP binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	305	R-HSA-9664646	Reactome pathway/reaction R-HSA-9664646	yes	reactome/R-HSA-9664646.md	Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	306	R-HSA-9664664	Reactome pathway/reaction R-HSA-9664664	yes	reactome/R-HSA-9664664.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	307	R-HSA-9664933	Reactome pathway/reaction R-HSA-9664933	yes	reactome/R-HSA-9664933.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	308	R-HSA-9664940	Reactome pathway/reaction R-HSA-9664940	yes	reactome/R-HSA-9664940.md	PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	309	R-HSA-9665407	Reactome pathway/reaction R-HSA-9665407	yes	reactome/R-HSA-9665407.md	PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	310	R-HSA-9665415	Reactome pathway/reaction R-HSA-9665415	yes	reactome/R-HSA-9665415.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	311	R-HSA-9670431	Reactome pathway/reaction R-HSA-9670431	yes	reactome/R-HSA-9670431.md	Phosphorylated KIT mutants bind PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	312	R-HSA-9670433	Reactome pathway/reaction R-HSA-9670433	yes	reactome/R-HSA-9670433.md	KIT mutants:PI3K catalyze synthesis of PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	313	R-HSA-9672162	Reactome pathway/reaction R-HSA-9672162	yes	reactome/R-HSA-9672162.md	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	314	R-HSA-9672172	Reactome pathway/reaction R-HSA-9672172	yes	reactome/R-HSA-9672172.md	PI3-kinase binds to mutant PDGFR receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	315	R-HSA-9672177	Reactome pathway/reaction R-HSA-9672177	yes	reactome/R-HSA-9672177.md	PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	316	R-HSA-9672178	Reactome pathway/reaction R-HSA-9672178	yes	reactome/R-HSA-9672178.md	PI3-kinase binds to PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	317	R-HSA-9698170	Reactome pathway/reaction R-HSA-9698170	yes	reactome/R-HSA-9698170.md	Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	318	R-HSA-9698174	Reactome pathway/reaction R-HSA-9698174	yes	reactome/R-HSA-9698174.md	FLT3 mutants recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	319	R-HSA-9703434	Reactome pathway/reaction R-HSA-9703434	yes	reactome/R-HSA-9703434.md	FLT3 fusions recruit PIK3CA through PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	320	R-HSA-9706340	Reactome pathway/reaction R-HSA-9706340	yes	reactome/R-HSA-9706340.md	Active FLT3:p-Y-GRB10 binds PIK3R1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	321	R-HSA-9706345	Reactome pathway/reaction R-HSA-9706345	yes	reactome/R-HSA-9706345.md	Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	322	R-HSA-9712078	Reactome pathway/reaction R-HSA-9712078	yes	reactome/R-HSA-9712078.md	ALK mutants bind PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	323	R-HSA-9712083	Reactome pathway/reaction R-HSA-9712083	yes	reactome/R-HSA-9712083.md	ALK mutants bind PI3KCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	324	R-HSA-9712084	Reactome pathway/reaction R-HSA-9712084	yes	reactome/R-HSA-9712084.md	PI3K synthesizes PIP3 downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	325	R-HSA-9842649	Reactome pathway/reaction R-HSA-9842649	yes	reactome/R-HSA-9842649.md	Active LTK receptor binds PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	326	R-HSA-9845032	Reactome pathway/reaction R-HSA-9845032	yes	reactome/R-HSA-9845032.md	CLIP1-LTK fusion binds PI3K to activate AKT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization of p85α / the class IA PI3K holoenzyme (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	327	R-HSA-1250189	Reactome pathway/reaction R-HSA-1250189	yes	reactome/R-HSA-1250189.md	Binding of PI3K to ERBB2:p-ERBB3 heterodimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	328	R-HSA-1250462	Reactome pathway/reaction R-HSA-1250462	yes	reactome/R-HSA-1250462.md	PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	329	R-HSA-1306957	Reactome pathway/reaction R-HSA-1306957	yes	reactome/R-HSA-1306957.md	PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	330	R-HSA-1306965	Reactome pathway/reaction R-HSA-1306965	yes	reactome/R-HSA-1306965.md	Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	331	R-HSA-2045911	Reactome pathway/reaction R-HSA-2045911	yes	reactome/R-HSA-2045911.md	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	332	R-HSA-2076220	Reactome pathway/reaction R-HSA-2076220	yes	reactome/R-HSA-2076220.md	CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	333	R-HSA-2316434	Reactome pathway/reaction R-HSA-2316434	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	334	R-HSA-2394007	Reactome pathway/reaction R-HSA-2394007	yes	reactome/R-HSA-2394007.md	PI3K gain of function mutants phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	335	R-HSA-2400009	Reactome pathway/reaction R-HSA-2400009	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R1	genes/human/PIK3R1/PIK3R1-ai-review.yaml	PIK3R1	P27986	NCBITaxon:9606	Homo sapiens	336	R-HSA-9606887	Reactome pathway/reaction R-HSA-9606887	yes	reactome/R-HSA-9606887.md	p-CD19:VAV binds PI3K and GRB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization of the PI3K complex (Reactome TAS).
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	40	R-HSA-6798174	PIK3C3:PIK3R4 phosphorylates PI to PI3P	yes	reactome/R-HSA-6798174.md	PIK3C3:PIK3R4 phosphorylates PI to PI3P	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Phagocytic vesicle membrane is plausible PI3P/PIK3C3 complex context but is not a core PIK3R4 function in this review.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	45	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	46	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	47	R-HSA-1675939	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane	yes	reactome/R-HSA-1675939.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	48	R-HSA-1675961	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane	yes	reactome/R-HSA-1675961.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	49	R-HSA-1676024	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane	yes	reactome/R-HSA-1676024.md	PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	50	R-HSA-188002	Rab5-mediated recruitment of class III PI3K to TLR9	yes	reactome/R-HSA-188002.md	Rab5-mediated recruitment of class III PI3K to TLR9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	51	R-HSA-5672012	Beclin-1 complex phosphorylates PtdIns	yes	reactome/R-HSA-5672012.md	Beclin-1 complex phosphorylates PtdIns	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	52	R-HSA-5678313	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	yes	reactome/R-HSA-5678313.md	AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	53	R-HSA-5678315	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	yes	reactome/R-HSA-5678315.md	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	54	R-HSA-5679205	ULK1 phosphorylates Beclin-1	yes	reactome/R-HSA-5679205.md	ULK1 phosphorylates Beclin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	55	R-HSA-5679266	Beclin-1 complex translocates to the ER	yes	reactome/R-HSA-5679266.md	Beclin-1 complex translocates to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	56	R-HSA-5682385	The phagophore extends from the PIP3-enriched structure	yes	reactome/R-HSA-5682385.md	The phagophore extends from the PIP3-enriched structure	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	57	R-HSA-9755359	SARS-CoV-2 8:class I MHC binds BECN1	yes	reactome/R-HSA-9755359.md	SARS-CoV-2 8:class I MHC binds BECN1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIK3R4	genes/human/PIK3R4/PIK3R4-ai-review.yaml	PIK3R4	Q99570	NCBITaxon:9606	Homo sapiens	58	R-HSA-9921171	NS1 binds Beclin-1	yes	reactome/R-HSA-9921171.md	NS1 binds Beclin-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a supported broad location for PIK3R4-containing PI3KC3 complexes.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	9	R-HSA-1660499	Synthesis of PIPs at the plasma membrane	yes	reactome/R-HSA-1660499.md	Synthesis of PIPs at the plasma membrane	Homo sapiens	GO:0006661	phosphatidylinositol biosynthetic process	TAS	involved_in	BP	false		MODIFY	The annotation captures phosphatidylinositol metabolism, but it is broader than the specific PI phosphate biosynthetic role of PIP5K1B.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	10	R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	yes	reactome/R-HSA-6811558.md	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Homo sapiens	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	PI3K/AKT pathway effects are downstream of phosphoinositide metabolism and are secondary to the direct PIP5K1B lipid kinase function.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	11	R-HSA-1676134	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane	yes	reactome/R-HSA-1676134.md	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane	Homo sapiens	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome assigns this side-reaction/substrate context to PIP5K1B, but it is not the defining physiological activity. The falcon deep research notes that PI3P phosphorylation by type I PIP5Ks is observed in vitro, while PI4P remains the predominant cellular substrate.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	12	R-HSA-1676082	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane	yes	reactome/R-HSA-1676082.md	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane	Homo sapiens	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS	enables	MF	false		ACCEPT	This is the core PIP5K1B molecular function: phosphorylation of PI4P at the 5 position to generate PI(4,5)P2/PIP2.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	13	R-HSA-1675810	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane	yes	reactome/R-HSA-1675810.md	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane	Homo sapiens	GO:0052810	1-phosphatidylinositol-5-kinase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome assigns this side-reaction/substrate context to PIP5K1B, but it is not the defining physiological activity.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	14	R-HSA-1675773	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane	yes	reactome/R-HSA-1675773.md	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane	Homo sapiens	GO:0052742	phosphatidylinositol kinase activity	TAS	enables	MF	false		MODIFY	Phosphatidylinositol kinase activity is true but too general for PIP5K1B, whose defining activity is PI4P 5-kinase activity.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	17	R-HSA-1675773	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane	yes	reactome/R-HSA-1675773.md	PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	18	R-HSA-1675810	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane	yes	reactome/R-HSA-1675810.md	PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	19	R-HSA-1676082	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane	yes	reactome/R-HSA-1676082.md	PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	20	R-HSA-1676134	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane	yes	reactome/R-HSA-1676134.md	PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	21	R-HSA-1676145	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane	yes	reactome/R-HSA-1676145.md	PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	22	R-HSA-3772434	Phosphorylated DVL recruits PIP5K1B to the plasma membrane	yes	reactome/R-HSA-3772434.md	Phosphorylated DVL recruits PIP5K1B to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PIP5K1B	genes/human/PIP5K1B/PIP5K1B-ai-review.yaml	PIP5K1B	O14986	NCBITaxon:9606	Homo sapiens	23	R-HSA-3772436	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2	yes	reactome/R-HSA-3772436.md	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol is a correct broad localization for PIP5K1B, but it does not capture the membrane-associated catalytic biology.
human	PKLR	genes/human/PKLR/PKLR-ai-review.yaml	PKLR	P30613	NCBITaxon:9606	Homo sapiens	20	R-HSA-70268	Pyruvate metabolism	yes	reactome/R-HSA-70268.md	Pyruvate metabolism	Homo sapiens	GO:0042866	pyruvate biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-asserted involvement in pyruvate biosynthesis, reflecting that pyruvate is the product of the pyruvate kinase reaction.
human	PKLR	genes/human/PKLR/PKLR-ai-review.yaml	PKLR	P30613	NCBITaxon:9606	Homo sapiens	21	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted participation in canonical glycolysis (Embden-Meyerhof-Parnas pathway), the final ATP-generating step of which PKLR catalyses.
human	PKLR	genes/human/PKLR/PKLR-ai-review.yaml	PKLR	P30613	NCBITaxon:9606	Homo sapiens	25	R-HSA-71670	Pyruvate kinase dephosphorylates PEP to PYR	yes	reactome/R-HSA-71670.md	Pyruvate kinase dephosphorylates PEP to PYR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization, the compartment where PKLR catalyses the glycolytic pyruvate kinase reaction.
human	PKLR	genes/human/PKLR/PKLR-ai-review.yaml	PKLR	P30613	NCBITaxon:9606	Homo sapiens	26	R-HSA-9727857	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL	yes	reactome/R-HSA-9727857.md	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization (from a SARS-CoV-1 host-interaction model), consistent with PKLR being a soluble cytosolic enzyme.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	39	R-HSA-9766062	PKM and TGIF2 bind CDH1 gene promoter	yes	reactome/R-HSA-9766062.md	PKM and TGIF2 bind CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		MODIFY	Reactome pathway annotation for PKM and TGIF2 binding CDH1 gene promoter. This nuclear function is PKM2-specific based on literature evidence.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	40	R-HSA-9861640	CTLH E3 ligase ubiquitinates PKM-1	yes	reactome/R-HSA-9861640.md	CTLH E3 ligase ubiquitinates PKM-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for CTLH E3 ligase ubiquitinating PKM-1. Cytosolic localization is correct for both isoforms.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	50	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for exocytosis of secretory granule lumen proteins. PKM found in extracellular region via secretion.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	51	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for ficolin-rich granule exocytosis. PKM present in extracellular region.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	52	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	PKM present in secretory granule lumen per Reactome annotation.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	53	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	PKM present in ficolin-1-rich granule lumen per Reactome annotation.
human	PKM	genes/human/PKM/PKM-ai-review.yaml	PKM	P14618	NCBITaxon:9606	Homo sapiens	66	R-HSA-71670	Pyruvate kinase dephosphorylates PEP to PYR	yes	reactome/R-HSA-71670.md	Pyruvate kinase dephosphorylates PEP to PYR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for pyruvate kinase reaction. Cytosolic localization correct for glycolytic function.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	2	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	PKMYT1 is a component of the regulatory machinery of the G2/M transition: it is one of the two WEE1-family kinases that impose inhibitory phosphorylation on cyclin B-CDK1 and hold mitotic entry in check until CDC25 reverses it.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	11	R-HSA-170055	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170055.md	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes' - the canonical PKMYT1 reaction.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	12	R-HSA-170116	PKMYT1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170116.md	PKMYT1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PKMYT1 phosphorylates CCNA:CDK1' - inhibitory phosphorylation of cyclin A-bound CDK1, consistent with PKMYT1's requirement for cyclin-bound CDK1 rather than for cyclin B specifically.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	29	R-HSA-162657	Inactivation of Myt1 kinase	yes	reactome/R-HSA-162657.md	Inactivation of Myt1 kinase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		REMOVE	Compartment assignment attached to the Reactome reaction 'Inactivation of Myt1 kinase'. The event it models - mitotic hyperphosphorylation of PKMYT1 and loss of cyclin B1-CDK1 binding - is real, but the nucleoplasm is not where PKMYT1 resides.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	37	R-HSA-170055	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	yes	reactome/R-HSA-170055.md	Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	Cytosol assignment attached to a Reactome reaction (Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes). PKMYT1's catalytic and docking regions do face the cytosol, but the protein itself is not a soluble cytosolic protein - it is peripherally attached to ER and Golgi membranes.
human	PKMYT1	genes/human/PKMYT1/PKMYT1-ai-review.yaml	PKMYT1	Q99640	NCBITaxon:9606	Homo sapiens	38	R-HSA-170116	PKMYT1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170116.md	PKMYT1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MODIFY	Cytosol assignment attached to a Reactome reaction (PKMYT1 phosphorylates CCNA:CDK1). PKMYT1's catalytic and docking regions do face the cytosol, but the protein itself is not a soluble cytosolic protein - it is peripherally attached to ER and Golgi membranes.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	53	R-HSA-5621481	C-type lectin receptors (CLRs)	yes	reactome/R-HSA-5621481.md	C-type lectin receptors (CLRs)	Homo sapiens	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	PLCG2 is a receptor-proximal transducer in immune-receptor pathways, especially BCR, Fc receptor, C-type lectin, and related hematopoietic signaling.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	54	R-HSA-76002	Platelet activation, signaling and aggregation	yes	reactome/R-HSA-76002.md	Platelet activation, signaling and aggregation	Homo sapiens	GO:0030168	platelet activation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	This immune-cell process is a plausible downstream or cell-type-specific outcome of PLCG2 receptor signaling.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	55	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	yes	reactome/R-HSA-2454202.md	Fc epsilon receptor (FCERI) signaling	Homo sapiens	GO:0038095	Fc-epsilon receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	PLCG2 is a receptor-proximal transducer in immune-receptor pathways, especially BCR, Fc receptor, C-type lectin, and related hematopoietic signaling.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	56	R-HSA-2730847	Hydrolysis of PIP2 by PLCG	yes	reactome/R-HSA-2730847.md	Hydrolysis of PIP2 by PLCG	Homo sapiens	GO:0004435	phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS	enables	MF	false		ACCEPT	PLCG2 is a phosphoinositide-specific phospholipase C that hydrolyzes PIP2 to IP3 and DAG after receptor-induced activation.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	57	R-HSA-5607735	p-Y753,Y759-PLCG2 hydrolyses PIP2	yes	reactome/R-HSA-5607735.md	p-Y753,Y759-PLCG2 hydrolyses PIP2	Homo sapiens	GO:0004435	phosphatidylinositol-4,5-bisphosphate phospholipase C activity	TAS	enables	MF	false		ACCEPT	PLCG2 is a phosphoinositide-specific phospholipase C that hydrolyzes PIP2 to IP3 and DAG after receptor-induced activation.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	58	R-HSA-1112666	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	yes	reactome/R-HSA-1112666.md	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	Homo sapiens	GO:0004629	C-type glycerophospholipase activity	TAS	enables	MF	false		MODIFY	The annotation is directionally correct but too broad for PLCG2; the specific biology is PIP2 phospholipase activity and phosphoinositide-mediated receptor signaling.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	59	R-HSA-114689	PLC gamma 2-mediated PIP2 hydrolysis	yes	reactome/R-HSA-114689.md	PLC gamma 2-mediated PIP2 hydrolysis	Homo sapiens	GO:0004629	C-type glycerophospholipase activity	TAS	enables	MF	false		MODIFY	The annotation is directionally correct but too broad for PLCG2; the specific biology is PIP2 phospholipase activity and phosphoinositide-mediated receptor signaling.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	116	R-HSA-5607755	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane	yes	reactome/R-HSA-5607755.md	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	117	R-HSA-5621347	PLCG2 translocates from cytosol to plasma membrane	yes	reactome/R-HSA-5621347.md	PLCG2 translocates from cytosol to plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	118	R-HSA-5621363	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2	yes	reactome/R-HSA-5621363.md	SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	119	R-HSA-5607735	p-Y753,Y759-PLCG2 hydrolyses PIP2	yes	reactome/R-HSA-5607735.md	p-Y753,Y759-PLCG2 hydrolyses PIP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	120	R-HSA-5607755	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane	yes	reactome/R-HSA-5607755.md	p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	121	R-HSA-5621347	PLCG2 translocates from cytosol to plasma membrane	yes	reactome/R-HSA-5621347.md	PLCG2 translocates from cytosol to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	123	R-HSA-2029268	Phosphorylation and activation of PLCG	yes	reactome/R-HSA-2029268.md	Phosphorylation and activation of PLCG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	124	R-HSA-2029270	Recruitment of PLCgamma to membrane	yes	reactome/R-HSA-2029270.md	Recruitment of PLCgamma to membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	125	R-HSA-2396594	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2396594.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	126	R-HSA-2396606	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	yes	reactome/R-HSA-2396606.md	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	127	R-HSA-2424476	Activation of RAC1 by VAV2/3	yes	reactome/R-HSA-2424476.md	Activation of RAC1 by VAV2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	128	R-HSA-2424481	Recruitment of VAV and BTK to p-SLP-76	yes	reactome/R-HSA-2424481.md	Recruitment of VAV and BTK to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	129	R-HSA-2424484	Phosphorylation of BTK by p-SYK	yes	reactome/R-HSA-2424484.md	Phosphorylation of BTK by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	130	R-HSA-2424486	Phosphorylation and activation of VAV2/VAV3 by SYK	yes	reactome/R-HSA-2424486.md	Phosphorylation and activation of VAV2/VAV3 by SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	131	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	yes	reactome/R-HSA-2424487.md	Phosphorylation of PLC-gamma by p-BTK/p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	132	R-HSA-2730833	Phosphorylation of TEC kinases by p-SYK	yes	reactome/R-HSA-2730833.md	Phosphorylation of TEC kinases by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	133	R-HSA-2730840	Activation of RAC1 by VAV	yes	reactome/R-HSA-2730840.md	Activation of RAC1 by VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	134	R-HSA-2730841	Phosphorylation and activation of VAV	yes	reactome/R-HSA-2730841.md	Phosphorylation and activation of VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	135	R-HSA-2730851	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2730851.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	136	R-HSA-2730856	Autophosphorylation of PAK	yes	reactome/R-HSA-2730856.md	Autophosphorylation of PAK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	137	R-HSA-2730858	Autophosphorylation of BTK/ITK	yes	reactome/R-HSA-2730858.md	Autophosphorylation of BTK/ITK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	138	R-HSA-2730889	Recruitment of PAK to the membrane by binding active RAC1	yes	reactome/R-HSA-2730889.md	Recruitment of PAK to the membrane by binding active RAC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	139	R-HSA-2730892	Recruitment of VAV to p-SLP-76	yes	reactome/R-HSA-2730892.md	Recruitment of VAV to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	140	R-HSA-9606151	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	yes	reactome/R-HSA-9606151.md	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	141	R-HSA-9606894	p-DAPP1 (p-BAM32) binds PLCG2	yes	reactome/R-HSA-9606894.md	p-DAPP1 (p-BAM32) binds PLCG2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	142	R-HSA-9664270	Recruitment of PLCgamma to membrane due to FCGR3A effect	yes	reactome/R-HSA-9664270.md	Recruitment of PLCgamma to membrane due to FCGR3A effect	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	143	R-HSA-9664278	Phosphorylation and activation of PLCG due to FCGR3A effect	yes	reactome/R-HSA-9664278.md	Phosphorylation and activation of PLCG due to FCGR3A effect	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	144	R-HSA-9691421	BTK binds BTK inhibitors	yes	reactome/R-HSA-9691421.md	BTK binds BTK inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	145	R-HSA-1112666	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	yes	reactome/R-HSA-1112666.md	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	146	R-HSA-202407	PLC-gamma1 hydrolyses PIP2	yes	reactome/R-HSA-202407.md	PLC-gamma1 hydrolyses PIP2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	147	R-HSA-2029268	Phosphorylation and activation of PLCG	yes	reactome/R-HSA-2029268.md	Phosphorylation and activation of PLCG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	148	R-HSA-2029272	Release of PLCG from FCGR	yes	reactome/R-HSA-2029272.md	Release of PLCG from FCGR	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	149	R-HSA-2424485	Release of p-PLCG1	yes	reactome/R-HSA-2424485.md	Release of p-PLCG1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	150	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	yes	reactome/R-HSA-2424487.md	Phosphorylation of PLC-gamma by p-BTK/p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	151	R-HSA-2730847	Hydrolysis of PIP2 by PLCG	yes	reactome/R-HSA-2730847.md	Hydrolysis of PIP2 by PLCG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	152	R-HSA-9664271	Release of PLCG from FCGR3A	yes	reactome/R-HSA-9664271.md	Release of PLCG from FCGR3A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	153	R-HSA-9664278	Phosphorylation and activation of PLCG due to FCGR3A effect	yes	reactome/R-HSA-9664278.md	Phosphorylation and activation of PLCG due to FCGR3A effect	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	154	R-HSA-114689	PLC gamma 2-mediated PIP2 hydrolysis	yes	reactome/R-HSA-114689.md	PLC gamma 2-mediated PIP2 hydrolysis	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	155	R-HSA-1855221	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane	yes	reactome/R-HSA-1855221.md	PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLCG2	genes/human/PLCG2/PLCG2-ai-review.yaml	PLCG2	P16885	NCBITaxon:9606	Homo sapiens	156	R-HSA-429497	SLP-76 stimulates PLC gamma 2	yes	reactome/R-HSA-429497.md	SLP-76 stimulates PLC gamma 2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	PLCG2 functions from cytosolic pools that transiently translocate to plasma-membrane, membrane-raft, and ruffle signaling sites and can later appear in internal vesicles.
human	PLD4	genes/human/PLD4/PLD4-ai-review.yaml	PLD4	Q96BZ4	NCBITaxon:9606	Homo sapiens	26	R-HSA-1855214	INCORRECT ANNOTATION - This pathway confuses PLD4 with PLCD4. PLD4 does not hydrolyze PI(4,5)P2.	yes	reactome/R-HSA-1855214.md	PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The ER membrane localization is correct for PLD4 as a type II transmembrane protein, though the Reactome pathway context (R-HSA-1855214) incorrectly describes PLD4 function. PLD4 does NOT hydrolyze PI(4,5)P2.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	2	R-HSA-2500257	Resolution of Sister Chromatid Cohesion	yes	reactome/R-HSA-2500257.md	Resolution of Sister Chromatid Cohesion	Homo sapiens	GO:0000070	mitotic sister chromatid segregation	TAS	involved_in	BP	false		ACCEPT	Reactome 'Resolution of Sister Chromatid Cohesion': PLK1 phosphorylates the cohesin subunit STAG2/SA2 to drive prophase-pathway removal of arm cohesin, a prerequisite for sister chromatid segregation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	4	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome 'G2/M Transition': PLK1 activates CDC25C, primes WEE1 for SCF(beta-TrCP) degradation and inactivates PKMYT1, forming a feed-forward loop that drives CDK1-cyclin B activation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	11	R-HSA-68884	Mitotic Telophase/Cytokinesis	yes	reactome/R-HSA-68884.md	Mitotic Telophase/Cytokinesis	Homo sapiens	GO:0000281	mitotic cytokinesis	TAS	involved_in	BP	false		ACCEPT	Reactome 'Mitotic Telophase/Cytokinesis': PLK1 phosphorylates KIF20A/MKLP2, KIF23/MKLP1, PRC1 and RACGAP1 at the central spindle.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	61	R-HSA-156673	Regulation of KIF23 (MKLP1) by phosphorylation	yes	reactome/R-HSA-156673.md	Regulation of KIF23 (MKLP1) by phosphorylation	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Regulation of KIF23 (MKLP1) by phosphorylation'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	62	R-HSA-156678	Activation of Cdc25C	yes	reactome/R-HSA-156678.md	Activation of Cdc25C	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome 'Activation of Cdc25C': PLK1 phosphorylates and activates CDC25C. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	63	R-HSA-156682	PLK1 phosphorylates NUDC	yes	reactome/R-HSA-156682.md	PLK1 phosphorylates NUDC	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates NUDC'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	64	R-HSA-156699	Inactivation of Wee1 kinase	yes	reactome/R-HSA-156699.md	Inactivation of Wee1 kinase	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Inactivation of Wee1 kinase'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	65	R-HSA-156723	Regulation of KIF20A (MKL2) by phosphorylation	yes	reactome/R-HSA-156723.md	Regulation of KIF20A (MKL2) by phosphorylation	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Regulation of KIF20A (MKL2) by phosphorylation'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	66	R-HSA-162657	Inactivation of Myt1 kinase	yes	reactome/R-HSA-162657.md	Inactivation of Myt1 kinase	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Inactivation of Myt1 kinase'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	67	R-HSA-163010	Down Regulation of Emi1 through Phosphorylation of Emi1	yes	reactome/R-HSA-163010.md	Down Regulation of Emi1 through Phosphorylation of Emi1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Down Regulation of Emi1 through Phosphorylation of Emi1'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	68	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Phosphorylation of cohesin by PLK1 at centromeres'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	69	R-HSA-174119	Free APC/C phosphorylated by Plk1	yes	reactome/R-HSA-174119.md	Free APC/C phosphorylated by Plk1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Free APC/C phosphorylated by Plk1'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	70	R-HSA-174174	Phosphorylation of the Emi1 DSGxxS degron by Plk1	yes	reactome/R-HSA-174174.md	Phosphorylation of the Emi1 DSGxxS degron by Plk1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Phosphorylation of the Emi1 DSGxxS degron by Plk1'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	71	R-HSA-2214351	PLK1 phosphorylates GORASP1	yes	reactome/R-HSA-2214351.md	PLK1 phosphorylates GORASP1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates GORASP1'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	72	R-HSA-2294580	PLK1 hyperphosphorylates Condensin II complex	yes	reactome/R-HSA-2294580.md	PLK1 hyperphosphorylates Condensin II complex	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 hyperphosphorylates Condensin II complex'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	73	R-HSA-2466068	Phosphorylation of cohesin by PLK1 at chromosomal arms	yes	reactome/R-HSA-2466068.md	Phosphorylation of cohesin by PLK1 at chromosomal arms	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'Phosphorylation of cohesin by PLK1 at chromosomal arms'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	74	R-HSA-2562526	PLK1 phosphorylates OPTN	yes	reactome/R-HSA-2562526.md	PLK1 phosphorylates OPTN	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates OPTN'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	75	R-HSA-2984226	PLK1 phosphorylates NEK9	yes	reactome/R-HSA-2984226.md	PLK1 phosphorylates NEK9	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates NEK9'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	76	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome 'Plk1-mediated phosphorylation of Nlp': PLK1 phosphorylates ninein-like protein (NINL), displacing it from maturing centrosomes. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	77	R-HSA-9851972	PLK1 phosphorylates FIRRM at S43	yes	reactome/R-HSA-9851972.md	PLK1 phosphorylates FIRRM at S43	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates FIRRM at S43'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	78	R-HSA-9853369	PLK1 phosphorylates FIRMM at S744	yes	reactome/R-HSA-9853369.md	PLK1 phosphorylates FIRMM at S744	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction 'PLK1 phosphorylates FIRMM at S744'. Protein serine/threonine kinase activity is the defining molecular function of PLK1; the kinase domain (residues ~39-325) phosphorylates Ser/Thr on substrates docked via the C-terminal polo-box domain.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	175	R-HSA-156673	Regulation of KIF23 (MKLP1) by phosphorylation	yes	reactome/R-HSA-156673.md	Regulation of KIF23 (MKLP1) by phosphorylation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Regulation of KIF23 (MKLP1) by phosphorylation) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	176	R-HSA-156699	Inactivation of Wee1 kinase	yes	reactome/R-HSA-156699.md	Inactivation of Wee1 kinase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Inactivation of Wee1 kinase) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	177	R-HSA-156723	Regulation of KIF20A (MKL2) by phosphorylation	yes	reactome/R-HSA-156723.md	Regulation of KIF20A (MKL2) by phosphorylation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Regulation of KIF20A (MKL2) by phosphorylation) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	178	R-HSA-162657	Inactivation of Myt1 kinase	yes	reactome/R-HSA-162657.md	Inactivation of Myt1 kinase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Inactivation of Myt1 kinase) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	179	R-HSA-163010	Down Regulation of Emi1 through Phosphorylation of Emi1	yes	reactome/R-HSA-163010.md	Down Regulation of Emi1 through Phosphorylation of Emi1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Down Regulation of Emi1 through Phosphorylation of Emi1) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	180	R-HSA-174119	Free APC/C phosphorylated by Plk1	yes	reactome/R-HSA-174119.md	Free APC/C phosphorylated by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Free APC/C phosphorylated by Plk1) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	181	R-HSA-174174	Phosphorylation of the Emi1 DSGxxS degron by Plk1	yes	reactome/R-HSA-174174.md	Phosphorylation of the Emi1 DSGxxS degron by Plk1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (Phosphorylation of the Emi1 DSGxxS degron by Plk1) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	182	R-HSA-2294580	PLK1 hyperphosphorylates Condensin II complex	yes	reactome/R-HSA-2294580.md	PLK1 hyperphosphorylates Condensin II complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places this PLK1 reaction (PLK1 hyperphosphorylates Condensin II complex) in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	183	R-HSA-2294590	PLK1 binds phosphorylated condensin II complex	yes	reactome/R-HSA-2294590.md	PLK1 binds phosphorylated condensin II complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome 'PLK1 binds phosphorylated condensin II complex' in the nucleoplasm.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	184	R-HSA-3002798	Cytosolic PLK1 translocates to the nucleus	yes	reactome/R-HSA-3002798.md	Cytosolic PLK1 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome 'Cytosolic PLK1 translocates to the nucleus'.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	185	R-HSA-3002811	Myosin phosphatase dephosphorylates PLK1	yes	reactome/R-HSA-3002811.md	Myosin phosphatase dephosphorylates PLK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome 'Myosin phosphatase dephosphorylates PLK1' (nucleoplasm).
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	186	R-HSA-4088130	PLK1 binds FOXM1	yes	reactome/R-HSA-4088130.md	PLK1 binds FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome 'PLK1 binds FOXM1' (nucleoplasm).
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	187	R-HSA-4088134	PLK1 phosphorylates FOXM1	yes	reactome/R-HSA-4088134.md	PLK1 phosphorylates FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome 'PLK1 phosphorylates FOXM1' (nucleoplasm).
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	206	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Mad1 binds kinetochore' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	207	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'MAD2 converted to an inhibitory state via interaction with Mad1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	208	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'MAD2 associates with the Mad1 kinetochore complex' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	209	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Release of activated MAD2 from kinetochores' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	210	R-HSA-156678	Activation of Cdc25C	yes	reactome/R-HSA-156678.md	Activation of Cdc25C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Activation of Cdc25C' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	211	R-HSA-156682	PLK1 phosphorylates NUDC	yes	reactome/R-HSA-156682.md	PLK1 phosphorylates NUDC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates NUDC' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	212	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Phosphorylation of cohesin by PLK1 at centromeres' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	213	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PP2A-B56 dephosphorylates centromeric cohesin' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	214	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Association of cell cycle proteins with the APC/C:Cdh1 complex' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	215	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Degradation of multiubiquitinated cell cycle proteins' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	216	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	217	R-HSA-2214351	PLK1 phosphorylates GORASP1	yes	reactome/R-HSA-2214351.md	PLK1 phosphorylates GORASP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates GORASP1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	218	R-HSA-2466068	Phosphorylation of cohesin by PLK1 at chromosomal arms	yes	reactome/R-HSA-2466068.md	Phosphorylation of cohesin by PLK1 at chromosomal arms	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Phosphorylation of cohesin by PLK1 at chromosomal arms' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	219	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'ESPL1 (Separase) cleaves centromeric cohesin' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	220	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Separation of sister chromatids' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	221	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'CDK1 phosphorylates CDCA5 (Sororin) at centromeres' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	222	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Kinetochore assembly' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	223	R-HSA-2562526	PLK1 phosphorylates OPTN	yes	reactome/R-HSA-2562526.md	PLK1 phosphorylates OPTN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates OPTN' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	224	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'AJUBA facilitates AURKA autophosphorylation' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	225	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'AJUBA binds centrosome-associated AURKA' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	226	R-HSA-2984226	PLK1 phosphorylates NEK9	yes	reactome/R-HSA-2984226.md	PLK1 phosphorylates NEK9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates NEK9' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	227	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'AURKA phosphorylates PLK1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	228	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'BORA binds PLK1 and AURKA' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	229	R-HSA-3000327	PLK1 phosphorylates BORA	yes	reactome/R-HSA-3000327.md	PLK1 phosphorylates BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates BORA' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	230	R-HSA-3002798	Cytosolic PLK1 translocates to the nucleus	yes	reactome/R-HSA-3002798.md	Cytosolic PLK1 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Cytosolic PLK1 translocates to the nucleus' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	231	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Kinetochore capture of astral microtubules' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	232	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Plk1-mediated phosphorylation of Nlp' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	233	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	234	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Loss of C-Nap-1 from centrosomes' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	235	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Dissociation of Phospho-Nlp from the centrosome' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	236	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Recruitment of Plk1 to centrosomes' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	237	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Association of NuMA with microtubules' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	238	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Recruitment of CDK11p58 to the centrosomes' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	239	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Translocation of NuMA to the centrosomes' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	240	R-HSA-4088305	FOXM1 stimulates PLK1 transcription	yes	reactome/R-HSA-4088305.md	FOXM1 stimulates PLK1 transcription	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'FOXM1 stimulates PLK1 transcription' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	241	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'RAB3IP stimulates nucleotide exchange on RAB8A' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	242	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'C2CD3 binds the mother centriole' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	243	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	244	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'CP110 and CEP97 dissociate from the centriole' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	245	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'The distal appendage proteins recruit TTBK2' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	246	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Recruitment of transition zone proteins' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	247	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'MARK4 binds ODF2 in the centriole' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	248	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	249	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'CDC42:GTP recruits DIAPH2-2 to kinetochores' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	250	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'AURKB phosphorylates DIAPH2-2 at kinetochores' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	251	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	252	R-HSA-8852317	PLK1 phosphorylates GTSE1	yes	reactome/R-HSA-8852317.md	PLK1 phosphorylates GTSE1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates GTSE1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	253	R-HSA-8852324	GTSE1 binds PLK1	yes	reactome/R-HSA-8852324.md	GTSE1 binds PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'GTSE1 binds PLK1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	254	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'TPX2 binds AURKA at centrosomes' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	255	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'TPX2 promotes AURKA autophosphorylation' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	256	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'EML4 recruits NUDC to mitotic spindle' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	257	R-HSA-9851946	FIRRM binds PLK1	yes	reactome/R-HSA-9851946.md	FIRRM binds PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'FIRRM binds PLK1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	258	R-HSA-9851972	PLK1 phosphorylates FIRRM at S43	yes	reactome/R-HSA-9851972.md	PLK1 phosphorylates FIRRM at S43	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates FIRRM at S43' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	259	R-HSA-9853369	PLK1 phosphorylates FIRMM at S744	yes	reactome/R-HSA-9853369.md	PLK1 phosphorylates FIRMM at S744	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 phosphorylates FIRMM at S744' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	260	R-HSA-9853385	PPP1CC dephosphorylates PLK1	yes	reactome/R-HSA-9853385.md	PPP1CC dephosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PPP1CC dephosphorylates PLK1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	261	R-HSA-9858636	MITF-M-dependent PLK1 expression	yes	reactome/R-HSA-9858636.md	MITF-M-dependent PLK1 expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'MITF-M-dependent PLK1 expression' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	262	R-NUL-2423781	PLK1 binds phosphorylated Gorasp1	yes	reactome/R-NUL-2423781.md	PLK1 binds phosphorylated Gorasp1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome assigns the reaction 'PLK1 binds phosphorylated Gorasp1' to the cytosol; cytosolic PLK1 is the pool that acts on centrosomal, spindle, midzone and cytoplasmic substrates and is activated by AURKA/BORA before nuclear import.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	267	R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	yes	reactome/R-HSA-9648025.md	EML4 and NUDC in mitotic spindle formation	Homo sapiens	GO:0007052	mitotic spindle organization	TAS	involved_in	BP	false		ACCEPT	Reactome 'EML4 and NUDC in mitotic spindle formation': PLK1 phosphorylates NUDC.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	268	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0007062	sister chromatid cohesion	TAS	involved_in	BP	false		MODIFY	Reactome 'Phosphorylation of cohesin by PLK1 at centromeres': PLK1 phosphorylates STAG2/SA2 to promote cohesin release (prophase pathway); at centromeres this is counteracted by SGO1-PP2A.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	269	R-HSA-2466068	Phosphorylation of cohesin by PLK1 at chromosomal arms	yes	reactome/R-HSA-2466068.md	Phosphorylation of cohesin by PLK1 at chromosomal arms	Homo sapiens	GO:0007062	sister chromatid cohesion	TAS	involved_in	BP	false		MODIFY	Reactome 'Phosphorylation of cohesin by PLK1 at chromosomal arms': PLK1-phosphorylated STAG2/SA2 cohesin is released from arms in prophase.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	270	R-HSA-2299718	Condensation of Prophase Chromosomes	yes	reactome/R-HSA-2299718.md	Condensation of Prophase Chromosomes	Homo sapiens	GO:0007076	mitotic chromosome condensation	TAS	involved_in	BP	false		ACCEPT	Reactome: PLK1 hyperphosphorylates the CDK1-primed condensin II complex during prophase chromosome condensation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	271	R-HSA-2980766	Nuclear Envelope Breakdown	yes	reactome/R-HSA-2980766.md	Nuclear Envelope Breakdown	Homo sapiens	GO:0007077	mitotic nuclear membrane disassembly	TAS	involved_in	BP	false		ACCEPT	Reactome 'Nuclear Envelope Breakdown': PLK1 phosphorylates DCTN1/p150Glued (and other targets) to promote NEBD.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	272	R-HSA-68881	Mitotic Metaphase/Anaphase Transition	yes	reactome/R-HSA-68881.md	Mitotic Metaphase/Anaphase Transition	Homo sapiens	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome 'Mitotic Metaphase/Anaphase Transition': PLK1 phosphorylates EMI1 and APC/C to enable APC/C activation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	301	R-HSA-162658	Golgi Cisternae Pericentriolar Stack Reorganization	yes	reactome/R-HSA-162658.md	Golgi Cisternae Pericentriolar Stack Reorganization	Homo sapiens	GO:0048313	Golgi inheritance	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome 'Golgi Cisternae Pericentriolar Stack Reorganization': PLK1 phosphorylates GORASP1/GRASP65 to promote mitotic Golgi fragmentation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	304	R-HSA-156678	Activation of Cdc25C	yes	reactome/R-HSA-156678.md	Activation of Cdc25C	Homo sapiens	GO:0051726	regulation of cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome 'Activation of Cdc25C' by PLK1.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	305	R-HSA-156699	Inactivation of Wee1 kinase	yes	reactome/R-HSA-156699.md	Inactivation of Wee1 kinase	Homo sapiens	GO:0051726	regulation of cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome 'Inactivation of Wee1 kinase' by PLK1 phosphorylation.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	306	R-HSA-162657	Inactivation of Myt1 kinase	yes	reactome/R-HSA-162657.md	Inactivation of Myt1 kinase	Homo sapiens	GO:0051726	regulation of cell cycle	TAS	involved_in	BP	false		ACCEPT	Reactome 'Inactivation of Myt1 kinase' by PLK1.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	320	R-HSA-8852317	PLK1 phosphorylates GTSE1	yes	reactome/R-HSA-8852317.md	PLK1 phosphorylates GTSE1	Homo sapiens	GO:1900182	positive regulation of protein localization to nucleus	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome: PLK1 phosphorylates GTSE1 Ser435, promoting GTSE1 nuclear localization and p53 nuclear export during G2 checkpoint recovery.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	322	R-HSA-176412	Phosphorylation of the APC/C	yes	reactome/R-HSA-176412.md	Phosphorylation of the APC/C	Homo sapiens	GO:1901990	regulation of mitotic cell cycle phase transition	TAS	involved_in	BP	false		ACCEPT	Reactome 'Phosphorylation of the APC/C': PLK1 (with CDK1) phosphorylates APC/C to promote CDC20 binding.
human	PLK1	genes/human/PLK1/PLK1-ai-review.yaml	PLK1	P53350	NCBITaxon:9606	Homo sapiens	326	R-HSA-176408	Regulation of APC/C activators between G1/S and early anaphase	yes	reactome/R-HSA-176408.md	Regulation of APC/C activators between G1/S and early anaphase	Homo sapiens	GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome: PLK1 phosphorylates EMI1 and APC/C subunits, regulating APC/C-dependent degradation.
human	PM20D1	genes/human/PM20D1/PM20D1-ai-review.yaml	PM20D1	Q6GTS8	NCBITaxon:9606	Homo sapiens	9	R-HSA-9673053	PM20D1 transforms oleoyl-phe from oleate and phe	yes	reactome/R-HSA-9673053.md	PM20D1 transforms oleoyl-phe from oleate and phe	Homo sapiens	GO:1990845	adaptive thermogenesis	TAS	involved_in	BP	false		ACCEPT	ACCEPT. PM20D1 synthesizes N-acyl amino acids that function as UCP1-independent mitochondrial uncouplers, directly contributing to adaptive thermogenesis. This is supported by experimental evidence that PM20D1 overexpression increases energy expenditure and that N-acyl amino acids increase thermogenesis.
human	PM20D1	genes/human/PM20D1/PM20D1-ai-review.yaml	PM20D1	Q6GTS8	NCBITaxon:9606	Homo sapiens	10	R-HSA-9673054	PM20D1 hydrolyzes oleoyl-phe	yes	reactome/R-HSA-9673054.md	PM20D1 hydrolyzes oleoyl-phe	Homo sapiens	GO:1990845	adaptive thermogenesis	TAS	involved_in	BP	false		ACCEPT	ACCEPT. Same GO term from different Reactome pathway entry. Both the synthase and hydrolase reactions contribute to regulating N-acyl amino acid levels for thermogenesis. PM20D1 is highly expressed in brown adipose tissue and is cold-inducible.
human	PM20D1	genes/human/PM20D1/PM20D1-ai-review.yaml	PM20D1	Q6GTS8	NCBITaxon:9606	Homo sapiens	27	R-HSA-9673053	PM20D1 transforms oleoyl-phe from oleate and phe	yes	reactome/R-HSA-9673053.md	PM20D1 transforms oleoyl-phe from oleate and phe	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT. PM20D1 is a secreted enzyme that functions in the extracellular space. It has a classical signal peptide and is found in circulation associated with lipoproteins.
human	PM20D1	genes/human/PM20D1/PM20D1-ai-review.yaml	PM20D1	Q6GTS8	NCBITaxon:9606	Homo sapiens	28	R-HSA-9673054	PM20D1 hydrolyzes oleoyl-phe	yes	reactome/R-HSA-9673054.md	PM20D1 hydrolyzes oleoyl-phe	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	ACCEPT. PM20D1 is secreted and circulates in tight association with LDL and HDL lipoprotein particles, which function as co-activators of its enzymatic activity.
human	PMM2	genes/human/PMM2/PMM2-ai-review.yaml	PMM2	O15305	NCBITaxon:9606	Homo sapiens	14	R-HSA-446205	Synthesis of GDP-mannose	yes	reactome/R-HSA-446205.md	Synthesis of GDP-mannose	Homo sapiens	GO:0009298	GDP-mannose biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-curated involvement in GDP-mannose synthesis, matching the enzyme's committed pathway step. Core process annotation.
human	PMM2	genes/human/PMM2/PMM2-ai-review.yaml	PMM2	O15305	NCBITaxon:9606	Homo sapiens	16	R-HSA-3781926	Defective PMM2 does not isomerise Man6P to Man1P	yes	reactome/R-HSA-3781926.md	Defective PMM2 does not isomerise Man6P to Man1P	Homo sapiens	GO:0004615	phosphomannomutase activity	TAS	enables	MF	false		ACCEPT	Reactome-curated phosphomannomutase activity (Man6P->Man1P) for PMM2. Concordant with the experimental and IBA/IEA annotations of the same term.
human	PMM2	genes/human/PMM2/PMM2-ai-review.yaml	PMM2	O15305	NCBITaxon:9606	Homo sapiens	19	R-HSA-3781926	Defective PMM2 does not isomerise Man6P to Man1P	yes	reactome/R-HSA-3781926.md	Defective PMM2 does not isomerise Man6P to Man1P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization. Concordant with IDA/IBA/IEA evidence.
human	PMM2	genes/human/PMM2/PMM2-ai-review.yaml	PMM2	O15305	NCBITaxon:9606	Homo sapiens	20	R-HSA-446201	PMM1,2 isomerise Man6P to Man1P	yes	reactome/R-HSA-446201.md	PMM1,2 isomerise Man6P to Man1P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization (PMM1,2 isomerise Man6P to Man1P). Concordant with all other localization evidence.
human	PMPCA	genes/human/PMPCA/PMPCA-ai-review.yaml	PMPCA	Q10713	NCBITaxon:9606	Homo sapiens	19	R-HSA-8949649	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	yes	reactome/R-HSA-8949649.md	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	MPP acts in the mitochondrial matrix where imported precursor proteins are processed.
human	PMPCA	genes/human/PMPCA/PMPCA-ai-review.yaml	PMPCA	Q10713	NCBITaxon:9606	Homo sapiens	20	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	MPP acts in the mitochondrial matrix where imported precursor proteins are processed.
human	PMPCA	genes/human/PMPCA/PMPCA-ai-review.yaml	PMPCA	Q10713	NCBITaxon:9606	Homo sapiens	21	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	MPP acts in the mitochondrial matrix where imported precursor proteins are processed.
human	PMPCB	genes/human/PMPCB/PMPCB-ai-review.yaml	PMPCB	O75439	NCBITaxon:9606	Homo sapiens	13	R-HSA-8949215	Mitochondrial calcium ion transport	yes	reactome/R-HSA-8949215.md	Mitochondrial calcium ion transport	Homo sapiens	GO:0006851	mitochondrial calcium ion transmembrane transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Over-annotated. PMPCB can process proSMDT1/proEMRE, a component needed for MCU complex function, but PMPCB does not catalyze calcium transmembrane transport.
human	PMPCB	genes/human/PMPCB/PMPCB-ai-review.yaml	PMPCB	O75439	NCBITaxon:9606	Homo sapiens	14	R-HSA-8949649	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	yes	reactome/R-HSA-8949649.md	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	Homo sapiens	GO:0004222	metalloendopeptidase activity	TAS	enables	MF	false		ACCEPT	Correct and core. PMPCB is the catalytic Zn2+-dependent metalloendopeptidase subunit of MPP.
human	PMPCB	genes/human/PMPCB/PMPCB-ai-review.yaml	PMPCB	O75439	NCBITaxon:9606	Homo sapiens	19	R-HSA-8949649	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	yes	reactome/R-HSA-8949649.md	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Correct. MPP/PMPCB acts in the mitochondrial matrix after precursor import through TOM/TIM.
human	PMVK	genes/human/PMVK/PMVK-ai-review.yaml	PMVK	Q15126	NCBITaxon:9606	Homo sapiens	10	R-HSA-9969896	Lanosterol biosynthesis	yes	reactome/R-HSA-9969896.md	Lanosterol biosynthesis	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (Lanosterol biosynthesis) traceable-author annotation to cholesterol biosynthesis. Correct but a downstream branch relative to the core IPP-precursor role.
human	PMVK	genes/human/PMVK/PMVK-ai-review.yaml	PMVK	Q15126	NCBITaxon:9606	Homo sapiens	11	R-HSA-191422	Mevalonate-5-phosphate is further phosphorylated	yes	reactome/R-HSA-191422.md	Mevalonate-5-phosphate is further phosphorylated	Homo sapiens	GO:0004631	phosphomevalonate kinase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""Mevalonate-5-phosphate is further phosphorylated"" attributes the phosphomevalonate kinase activity to PMVK. Correct core molecular function."
human	PMVK	genes/human/PMVK/PMVK-ai-review.yaml	PMVK	Q15126	NCBITaxon:9606	Homo sapiens	12	R-HSA-1655839	Expression of Phosphomevalonate Kinase (PMVK)	yes	reactome/R-HSA-1655839.md	Expression of Phosphomevalonate Kinase (PMVK)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (Expression of PMVK) traceable-author cytosol location. Consistent with the experimental IDA cytosol annotations.
human	PMVK	genes/human/PMVK/PMVK-ai-review.yaml	PMVK	Q15126	NCBITaxon:9606	Homo sapiens	13	R-HSA-191422	Mevalonate-5-phosphate is further phosphorylated	yes	reactome/R-HSA-191422.md	Mevalonate-5-phosphate is further phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (mevalonate-5-phosphate phosphorylation reaction) traceable-author cytosol location. Consistent with the established cytosolic localization.
human	PNMT	genes/human/PNMT/PNMT-ai-review.yaml	PNMT	P11086	NCBITaxon:9606	Homo sapiens	6	R-HSA-209905	Catecholamine biosynthesis	yes	reactome/R-HSA-209905.md	Catecholamine biosynthesis	Homo sapiens	GO:0042423	catecholamine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	PNMT catalyzes the final step of the catecholamine biosynthetic pathway (adrenaline is a catecholamine), so this process annotation is correct, if more general than the specific epinephrine biosynthetic process.
human	PNMT	genes/human/PNMT/PNMT-ai-review.yaml	PNMT	P11086	NCBITaxon:9606	Homo sapiens	8	R-HSA-209903	Noradrenaline is converted to adrenaline	yes	reactome/R-HSA-209903.md	Noradrenaline is converted to adrenaline	Homo sapiens	GO:0004603	phenylethanolamine N-methyltransferase activity	TAS	enables	MF	false		ACCEPT	"Reactome curation of the reaction ""Noradrenaline is converted to adrenaline"" attributes PNMT's transmethylase activity. Correct core molecular function."
human	PNMT	genes/human/PNMT/PNMT-ai-review.yaml	PNMT	P11086	NCBITaxon:9606	Homo sapiens	13	R-HSA-209903	Noradrenaline is converted to adrenaline	yes	reactome/R-HSA-209903.md	Noradrenaline is converted to adrenaline	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the PNMT-catalyzed noradrenaline-to-adrenaline reaction in the cytosol, consistent with PNMT being a soluble cytoplasmic enzyme.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	26	R-HSA-9735775	Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (defective-PNP inosine reaction); correct core location.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	27	R-HSA-9735789	Defective PNP does not convert (deoxy)guanosine to guanine and (deoxy)ribose	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (defective-PNP guanosine reaction); correct.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	38	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular localization via Reactome neutrophil-degranulation (secretory-granule exocytosis) pathway; PNP is detected extracellularly but this is not its functional compartment.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	39	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular localization via Reactome ficolin-rich-granule exocytosis; detected extracellularly, non-functional compartment.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	40	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Secretory-granule-lumen localization from neutrophil-degranulation Reactome pathway; reflects presence in granules, not functional site.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	41	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Ficolin-1-rich granule lumen from neutrophil-degranulation Reactome; non-core localization.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	45	R-HSA-112033	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine	yes	reactome/R-HSA-112033.md	PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose-1-phosphate to (deoxy)inosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (PNP inosine synthesis reaction); correct core location.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	46	R-HSA-112034	PNP catalyzes the conversion of guanine and (deoxy)ribose-1-phosphate to (deoxy)guanosine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (PNP guanosine synthesis reaction); correct.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	47	R-HSA-74242	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (PNP inosine phosphorolysis); correct.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	48	R-HSA-74249	PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (PNP guanosine phosphorolysis); correct.
human	PNP	genes/human/PNP/PNP-ai-review.yaml	PNP	P00491	NCBITaxon:9606	Homo sapiens	49	R-HSA-9755044	PNP trimer transforms RBV to T-CONH2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (PNP-mediated ribavirin transformation); correct core location.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	25	R-HSA-1482883	Acyl chain remodeling of DAG and TAG	yes	reactome/R-HSA-1482883.md	Acyl chain remodeling of DAG and TAG	Homo sapiens	GO:0036155	acylglycerol acyl-chain remodeling	TAS	involved_in	BP	false		ACCEPT	Reactome pathway assignment for acyl-chain remodelling of DAG and TAG.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	26	R-HSA-1482811	DAG is hydrolyzed to 2-MAG by PNPLA2/3	yes	reactome/R-HSA-1482811.md	DAG is hydrolyzed to 2-MAG by PNPLA2/3	Homo sapiens	GO:0004465	lipoprotein lipase activity	TAS	enables	MF	false		MODIFY	Lipoprotein lipase activity asserted from the Reactome reaction 'DAG is hydrolyzed to 2-MAG by PNPLA2/3'.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	27	R-HSA-1482777	TAG is hydrolyzed to DAG by PNPLA2/3	yes	reactome/R-HSA-1482777.md	TAG is hydrolyzed to DAG by PNPLA2/3	Homo sapiens	GO:0004806	triacylglycerol lipase activity	TAS	enables	MF	false		ACCEPT	Triacylglycerol lipase activity, the activity PNPLA3 shares with its closest paralogue PNPLA2/ATGL.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	31	R-HSA-1482647	2-MAG and DAG are transacylated to TAG by PNPLA2/3	yes	reactome/R-HSA-1482647.md	2-MAG and DAG are transacylated to TAG by PNPLA2/3	Homo sapiens	GO:0016411	acylglycerol O-acyltransferase activity	TAS	enables	MF	false		MODIFY	Acyl transfer onto an acylglycerol, from the Reactome transacylation reactions.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	32	R-HSA-1482654	2-MAG is transacylated to DAG by PNPLA2/3	yes	reactome/R-HSA-1482654.md	2-MAG is transacylated to DAG by PNPLA2/3	Homo sapiens	GO:0016411	acylglycerol O-acyltransferase activity	TAS	enables	MF	false		MODIFY	Acyl transfer onto an acylglycerol, from the Reactome transacylation reactions.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	50	R-HSA-1482647	2-MAG and DAG are transacylated to TAG by PNPLA2/3	yes	reactome/R-HSA-1482647.md	2-MAG and DAG are transacylated to TAG by PNPLA2/3	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane location from Reactome.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	51	R-HSA-1482654	2-MAG is transacylated to DAG by PNPLA2/3	yes	reactome/R-HSA-1482654.md	2-MAG is transacylated to DAG by PNPLA2/3	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane location from Reactome.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	52	R-HSA-1482777	TAG is hydrolyzed to DAG by PNPLA2/3	yes	reactome/R-HSA-1482777.md	TAG is hydrolyzed to DAG by PNPLA2/3	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane location from Reactome.
human	PNPLA3	genes/human/PNPLA3/PNPLA3-ai-review.yaml	PNPLA3	Q9NST1	NCBITaxon:9606	Homo sapiens	53	R-HSA-1482811	DAG is hydrolyzed to 2-MAG by PNPLA2/3	yes	reactome/R-HSA-1482811.md	DAG is hydrolyzed to 2-MAG by PNPLA2/3	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane location from Reactome.
human	PNPO	genes/human/PNPO/PNPO-ai-review.yaml	PNPO	Q9NVS9	NCBITaxon:9606	Homo sapiens	20	R-HSA-965019	2xPNPO:2xFMN oxidizes PDXP to PXLP	yes	reactome/R-HSA-965019.md	2xPNPO:2xFMN oxidizes PDXP to PXLP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct subcellular localization. PNPO is a soluble cytosolic enzyme; Reactome localizes the PNP-to-PLP oxidation reaction to the cytosol. Core location.
human	PNPO	genes/human/PNPO/PNPO-ai-review.yaml	PNPO	Q9NVS9	NCBITaxon:9606	Homo sapiens	21	R-HSA-965079	2xPNPO:2xFMN oxidizes PXAP to PXLP	yes	reactome/R-HSA-965079.md	2xPNPO:2xFMN oxidizes PXAP to PXLP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct subcellular localization (Reactome reaction for the PMP-to-PLP oxidation, cytosol). Consistent with the companion cytosol annotation.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	30	R-HSA-110363	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	yes	reactome/R-HSA-110363.md	FEN1 bound to PCNA and APEX1 cleaves flap ssDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-derived nucleoplasm localization, consistent with IDA evidence.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	31	R-HSA-110364	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	yes	reactome/R-HSA-110364.md	PCNA:POLD,POLE:RPA:RFC and FEN1 bind APEX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome BER pathway localization; consistent with core nuclear function.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	32	R-HSA-110368	POLD,POLE-mediated DNA strand displacement synthesis	yes	reactome/R-HSA-110368.md	POLD,POLE-mediated DNA strand displacement synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome long-patch BER strand-displacement synthesis; supports core nuclear repair role.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	33	R-HSA-110371	LIG1 binds APEX1 and PCNA at SSB	yes	reactome/R-HSA-110371.md	LIG1 binds APEX1 and PCNA at SSB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome BER ligation step; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	34	R-HSA-174438	Formation of the Flap Intermediate on the C-strand	yes	reactome/R-HSA-174438.md	Formation of the Flap Intermediate on the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome telomere C-strand flap formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	35	R-HSA-174441	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand	yes	reactome/R-HSA-174441.md	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome RNA primer removal/lagging strand; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	36	R-HSA-174444	Formation of C-strand Okazaki fragments	yes	reactome/R-HSA-174444.md	Formation of C-strand Okazaki fragments	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome C-strand Okazaki fragment formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	37	R-HSA-174445	RPA binds to the Flap on the C-strand	yes	reactome/R-HSA-174445.md	RPA binds to the Flap on the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome RPA binding to C-strand flap; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	38	R-HSA-174446	Removal of remaining Flap from the C-strand	yes	reactome/R-HSA-174446.md	Removal of remaining Flap from the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome flap removal at C-strand; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	39	R-HSA-174448	Formation of Processive Complex on the C-strand of the telomere	yes	reactome/R-HSA-174448.md	Formation of Processive Complex on the C-strand of the telomere	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome telomere processive complex formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	40	R-HSA-174451	Recruitment of DNA2 endonuclease to the C strand	yes	reactome/R-HSA-174451.md	Recruitment of DNA2 endonuclease to the C strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome DNA2 recruitment at C-strand; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	41	R-HSA-174456	Joining of adjacent Okazaki fragments of the C-strand	yes	reactome/R-HSA-174456.md	Joining of adjacent Okazaki fragments of the C-strand	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome Okazaki fragment joining (C-strand); supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	42	R-HSA-176702	Disassociation of Processive Complex and Completed Telomere End	yes	reactome/R-HSA-176702.md	Disassociation of Processive Complex and Completed Telomere End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome telomere processive complex dissociation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	43	R-HSA-5358579	DNA polymerase delta polymerizes DNA across single stranded gap	yes	reactome/R-HSA-5358579.md	DNA polymerase delta polymerizes DNA across single stranded gap	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome Polδ gap-filling DNA synthesis; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	44	R-HSA-5651805	LIG1 bound to APEX1 and PCNA ligates SSB	yes	reactome/R-HSA-5651805.md	LIG1 bound to APEX1 and PCNA ligates SSB	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome BER LIG1 step; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	45	R-HSA-5651809	LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA	yes	reactome/R-HSA-5651809.md	LIG1, APEX1 and PCNA:POLD,POLE:RPA:RFC dissociate from repaired DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome BER complex dissociation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	46	R-HSA-5651992	PCNA-containing replication complex binds damaged dsDNA	yes	reactome/R-HSA-5651992.md	PCNA-containing replication complex binds damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome PCNA replication complex on damaged dsDNA; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	47	R-HSA-5652005	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	yes	reactome/R-HSA-5652005.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome RAD18/CUL4-DDB1-DTL ubiquitin ligase binding to PCNA replication complex; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	48	R-HSA-5652009	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	yes	reactome/R-HSA-5652009.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome PCNA monoubiquitination step; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	49	R-HSA-5653838	POLD,POLE binds deISGylated PCNA after TLS	yes	reactome/R-HSA-5653838.md	POLD,POLE binds deISGylated PCNA after TLS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome post-TLS Polδ/ε re-binding deISGylated PCNA; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	50	R-HSA-5653840	POLD,POLE complete replication of damaged DNA after TLS	yes	reactome/R-HSA-5653840.md	POLD,POLE complete replication of damaged DNA after TLS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome post-TLS completion of replication; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	51	R-HSA-5690213	DNA polymerases delta, epsilon or kappa bind the GG-NER site	yes	reactome/R-HSA-5690213.md	DNA polymerases delta, epsilon or kappa bind the GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome Polδ/ε/κ binding GG-NER site; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	52	R-HSA-5690988	3'-incision of DNA by ERCC5 (XPG) in GG-NER	yes	reactome/R-HSA-5690988.md	3'-incision of DNA by ERCC5 (XPG) in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ERCC5 3'-incision in GG-NER; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	53	R-HSA-5690997	Ligation of newly synthesized repair patch to incised DNA in GG-NER	yes	reactome/R-HSA-5690997.md	Ligation of newly synthesized repair patch to incised DNA in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome GG-NER repair patch ligation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	54	R-HSA-5691001	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER	yes	reactome/R-HSA-5691001.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome NER repair synthesis by Polδ/ε/κ; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	55	R-HSA-6782208	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	yes	reactome/R-HSA-6782208.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TC-NER repair synthesis; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	56	R-HSA-6782211	DNA polymerases delta, epsilon or kappa bind the TC-NER site	yes	reactome/R-HSA-6782211.md	DNA polymerases delta, epsilon or kappa bind the TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome Polδ/ε/κ binding TC-NER site; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	57	R-HSA-6782224	3' incision by ERCC5 (XPG) in TC-NER	yes	reactome/R-HSA-6782224.md	3' incision by ERCC5 (XPG) in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome ERCC5 3' incision in TC-NER; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	58	R-HSA-6782227	Ligation of newly synthesized repair patch to incised DNA in TC-NER	yes	reactome/R-HSA-6782227.md	Ligation of newly synthesized repair patch to incised DNA in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TC-NER repair ligation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	59	R-HSA-69074	Formation of Processive Complex	yes	reactome/R-HSA-69074.md	Formation of Processive Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome replication processive complex formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	60	R-HSA-69116	Formation of Okazaki fragments	yes	reactome/R-HSA-69116.md	Formation of Okazaki fragments	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome Okazaki fragment formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	61	R-HSA-69127	Formation of the Flap Intermediate	yes	reactome/R-HSA-69127.md	Formation of the Flap Intermediate	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome flap intermediate formation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	62	R-HSA-69140	RPA binds to the Flap	yes	reactome/R-HSA-69140.md	RPA binds to the Flap	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome RPA binding to flap; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	63	R-HSA-69142	Recruitment of Dna2 endonuclease	yes	reactome/R-HSA-69142.md	Recruitment of Dna2 endonuclease	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome DNA2 recruitment to flap; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	64	R-HSA-69144	Removal of RNA primer and dissociation of RPA and Dna2	yes	reactome/R-HSA-69144.md	Removal of RNA primer and dissociation of RPA and Dna2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome RNA primer removal/RPA-DNA2 dissociation; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	65	R-HSA-69152	Removal of remaining Flap	yes	reactome/R-HSA-69152.md	Removal of remaining Flap	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome remaining flap removal; supports nuclear localization.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	70	R-HSA-110368	POLD,POLE-mediated DNA strand displacement synthesis	yes	reactome/R-HSA-110368.md	POLD,POLE-mediated DNA strand displacement synthesis	Homo sapiens	GO:0006284	base-excision repair	TAS		UNKNOWN	false		NEW	NEW annotation. POLD2 is part of Polδ which performs long-patch BER strand displacement synthesis; supported by Reactome BER pathway entries already annotated to POLD2 (CC nucleoplasm) and Thomas et al. 2023 (PMID:36861411) identifying POLD2 as a BER pathway gene.
human	POLD2	genes/human/POLD2/POLD2-ai-review.yaml	POLD2	P49005	NCBITaxon:9606	Homo sapiens	71	R-HSA-5691001	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER	yes	reactome/R-HSA-5691001.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER	Homo sapiens	GO:0006289	nucleotide-excision repair	TAS		UNKNOWN	false		NEW	NEW annotation. POLD2 is part of Polδ which performs NER repair synthesis (~27-30 nt patch) in both GG-NER and TC-NER pathways, as captured by multiple Reactome NER entries already linked to POLD2.
human	POLE4	genes/human/POLE4/POLE4-ai-review.yaml	POLE4	Q9NR33	NCBITaxon:9606	Homo sapiens	17	R-HSA-68913	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin	yes	reactome/R-HSA-68913.md	The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm - nuclear protein at replication forks in nucleoplasm.
human	POLE4	genes/human/POLE4/POLE4-ai-review.yaml	POLE4	Q9NR33	NCBITaxon:9606	Homo sapiens	18	R-HSA-68914	DNA polymerase alpha:primase binds at the origin	yes	reactome/R-HSA-68914.md	DNA polymerase alpha:primase binds at the origin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm - nuclear protein at replication forks in nucleoplasm.
human	POLE4	genes/human/POLE4/POLE4-ai-review.yaml	POLE4	Q9NR33	NCBITaxon:9606	Homo sapiens	19	R-HSA-68960	DNA polymerase epsilon binds at the origin	yes	reactome/R-HSA-68960.md	DNA polymerase epsilon binds at the origin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm - nuclear protein at replication forks in nucleoplasm.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	18	R-HSA-379044	Liganded Gs-activating GPCR acts as a GEF for Gs	yes	reactome/R-HSA-379044.md	Liganded Gs-activating GPCR acts as a GEF for Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for GPCR signaling. Extracellular region is where ligands interact with receptors.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	19	R-HSA-388596	Melanocortin receptors bind melanocortins	yes	reactome/R-HSA-388596.md	Melanocortin receptors bind melanocortins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for melanocortin receptor binding. Multiple Reactome TAS annotations to same GO term represent different pathway contexts.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	20	R-HSA-744886	The Ligand:GPCR:Gs complex dissociates	yes	reactome/R-HSA-744886.md	The Ligand:GPCR:Gs complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GPCR:Gs complex dissociation pathway.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	21	R-HSA-744887	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	yes	reactome/R-HSA-744887.md	Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for liganded Gs-activating GPCRs.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	22	R-HSA-5603251	Defective ACTH does not bind MCR2	yes	reactome/R-HSA-5603251.md	Defective ACTH does not bind MCR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for defective ACTH not binding MC2R.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	23	R-HSA-112042	Opioid binds MOR	yes	reactome/R-HSA-112042.md	Opioid binds MOR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for opioid binding to MOR (mu opioid receptor). Beta-endorphin is the POMC product that binds opioid receptors.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	24	R-HSA-112271	The receptor:G-protein complex dissociates	yes	reactome/R-HSA-112271.md	The receptor:G-protein complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for receptor:G-protein complex dissociation in opioid signaling.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	25	R-HSA-167408	The high affinity receptor complex binds to G-protein	yes	reactome/R-HSA-167408.md	The high affinity receptor complex binds to G-protein	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for high affinity receptor:G-protein binding.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	26	R-HSA-167419	The receptor:G-protein complex releases GDP	yes	reactome/R-HSA-167419.md	The receptor:G-protein complex releases GDP	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GDP release from receptor:G-protein complex.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	27	R-HSA-167427	Opioid dissociates from MOR	yes	reactome/R-HSA-167427.md	Opioid dissociates from MOR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for opioid dissociation from MOR.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	28	R-HSA-167429	The receptor:G-protein complex binds GTP	yes	reactome/R-HSA-167429.md	The receptor:G-protein complex binds GTP	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GTP binding to receptor:G-protein complex.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	29	R-HSA-374298	Opioid receptors bind opioid peptides	yes	reactome/R-HSA-374298.md	Opioid receptors bind opioid peptides	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for opioid receptors binding opioid peptides.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	30	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Gi-coupled GPCR activation (opioid signaling).
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	31	R-HSA-388605	POMC(138-176) binds MC2R	yes	reactome/R-HSA-388605.md	POMC(138-176) binds MC2R	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation specifically for ACTH (POMC 138-176) binding MC2R.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	32	R-HSA-6789615	Expression of STAT3-upregulated extracellular proteins	yes	reactome/R-HSA-6789615.md	Expression of STAT3-upregulated extracellular proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for STAT3-upregulated extracellular proteins.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	33	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Gi complex dissociation.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	34	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Gi-coupled GPCR binding.
human	POMC	genes/human/POMC/POMC-ai-review.yaml	POMC	P01189	NCBITaxon:9606	Homo sapiens	35	R-HSA-265301	Corticotropin cleavage from POMC	yes	reactome/R-HSA-265301.md	Corticotropin cleavage from POMC	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		ACCEPT	Reactome annotation for corticotropin cleavage from POMC. Processing occurs in secretory granule lumen.
human	POMT1	genes/human/POMT1/POMT1-ai-review.yaml	POMT1	Q9Y6A1	NCBITaxon:9606	Homo sapiens	16	R-HSA-9816277	CDH1 is O-manosylated	yes	reactome/R-HSA-9816277.md	CDH1 is O-manosylated	Homo sapiens	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity	TAS	enables	MF	false		ACCEPT	O-mannosyltransferase activity - core enzymatic function.
human	POMT1	genes/human/POMT1/POMT1-ai-review.yaml	POMT1	Q9Y6A1	NCBITaxon:9606	Homo sapiens	21	R-HSA-5615556	Defective POMT2 does not transfer Man from Dol-P-Man to DAG1	yes	reactome/R-HSA-5615556.md	Defective POMT2 does not transfer Man from Dol-P-Man to DAG1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane.
human	POMT1	genes/human/POMT1/POMT1-ai-review.yaml	POMT1	Q9Y6A1	NCBITaxon:9606	Homo sapiens	22	R-HSA-5615604	Defective POMT1 does not transfer Man from Dol-P-Man to DAG1	yes	reactome/R-HSA-5615604.md	Defective POMT1 does not transfer Man from Dol-P-Man to DAG1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane.
human	POMT1	genes/human/POMT1/POMT1-ai-review.yaml	POMT1	Q9Y6A1	NCBITaxon:9606	Homo sapiens	23	R-HSA-5615637	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)	yes	reactome/R-HSA-5615637.md	POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane.
human	PPAT	genes/human/PPAT/PPAT-ai-review.yaml	PPAT	Q06203	NCBITaxon:9606	Homo sapiens	12	R-HSA-111285	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer	yes	reactome/R-HSA-111285.md	Formation of phosphoribosyl pyrophosphate amidotransferase tetramer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPAT is a cytosolic enzyme. Reactome describes cytosolic PPAT and its allosteric assembly, in which AMP, GMP and IMP promote dimer-to-tetramer association (the feedback-inhibited state).
human	PPAT	genes/human/PPAT/PPAT-ai-review.yaml	PPAT	Q06203	NCBITaxon:9606	Homo sapiens	13	R-HSA-111289	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer	yes	reactome/R-HSA-111289.md	Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization. Reactome documents that the substrate PRPP drives dissociation of the inactive tetramer into the active dimer, part of PPAT's cytosolic allosteric regulation.
human	PPAT	genes/human/PPAT/PPAT-ai-review.yaml	PPAT	Q06203	NCBITaxon:9606	Homo sapiens	14	R-HSA-73815	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate	yes	reactome/R-HSA-73815.md	5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization tied to the catalytic reaction itself. Reactome states that cytosolic PPAT catalyses the committed step of de novo purine synthesis, pulled forward by pyrophosphate hydrolysis.
human	PPCDC	genes/human/PPCDC/PPCDC-ai-review.yaml	PPCDC	Q96CD2	NCBITaxon:9606	Homo sapiens	13	R-HSA-196783	Coenzyme A biosynthesis	yes	reactome/R-HSA-196783.md	Coenzyme A biosynthesis	Homo sapiens	GO:0015937	coenzyme A biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing PPCDC in the CoA biosynthesis pathway. Correct core biological process.
human	PPCDC	genes/human/PPCDC/PPCDC-ai-review.yaml	PPCDC	Q96CD2	NCBITaxon:9606	Homo sapiens	23	R-HSA-196840	3xPPCDC:3FMN decarboxylates PPC	yes	reactome/R-HSA-196840.md	3xPPCDC:3FMN decarboxylates PPC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome). Consistent with the CoA biosynthesis pathway occurring in the cytosol and with the absence of any signal peptide or transmembrane region in the UniProt feature table. Correct core location.
human	PPCS	genes/human/PPCS/PPCS-ai-review.yaml	PPCS	Q9HAB8	NCBITaxon:9606	Homo sapiens	17	R-HSA-196753	2xPPCS ligates PPanK with Cys	yes	reactome/R-HSA-196753.md	2xPPCS ligates PPanK with Cys	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Core localization. The second step of CoA biosynthesis is catalyzed by cytosolic PPCS (Reactome), consistent with the cytosolic/mitochondrial-intermembrane-space localization of the CoA pathway.
human	PPIB	genes/human/PPIB/PPIB-ai-review.yaml	PPIB	P23284	NCBITaxon:9606	Homo sapiens	19	R-HSA-9728804	Reactome cytosol annotation for PPIB.	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (likely a pathway/context assignment); not the principal compartment for this ER-lumenal protein.
human	PPIB	genes/human/PPIB/PPIB-ai-review.yaml	PPIB	P23284	NCBITaxon:9606	Homo sapiens	46	R-HSA-1980233	Reactome collagen-biosynthesis ER-lumen annotation for PPIB.	yes	reactome/R-HSA-1980233.md	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome ER-lumen localization; correct and core.
human	PPIB	genes/human/PPIB/PPIB-ai-review.yaml	PPIB	P23284	NCBITaxon:9606	Homo sapiens	47	R-HSA-2022073	Reactome collagen-biosynthesis ER-lumen annotation for PPIB.	yes	reactome/R-HSA-2022073.md	Procollagen triple helix formation	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome ER-lumen localization (collagen biosynthesis pathway); correct and core.
human	PPIB	genes/human/PPIB/PPIB-ai-review.yaml	PPIB	P23284	NCBITaxon:9606	Homo sapiens	48	R-HSA-8948226	Reactome ER-lumen annotation for PPIB.	yes	reactome/R-HSA-8948226.md	Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides dissociates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome ER-lumen localization; correct and core.
human	PPIB	genes/human/PPIB/PPIB-ai-review.yaml	PPIB	P23284	NCBITaxon:9606	Homo sapiens	49	R-HSA-8948230	Reactome ER-lumen annotation for PPIB.	yes	reactome/R-HSA-8948230.md	P3HB binds 4-Hyp-collagen propeptides	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome ER-lumen localization; correct and core.
human	PPOX	genes/human/PPOX/PPOX-ai-review.yaml	PPOX	P50336	NCBITaxon:9606	Homo sapiens	21	R-HSA-189423	PPO oxidises PPGEN9 to PRIN9	yes	reactome/R-HSA-189423.md	PPO oxidises PPGEN9 to PRIN9	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome traceable-author-statement placing PPO on the outer surface of the inner mitochondrial membrane (facing the intermembrane space). As with the IEA IMS annotation, the intermembrane-space term overstates a soluble-luminal localisation.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	80	R-HSA-9860927	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	yes	reactome/R-HSA-9860927.md	Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Homo sapiens	GO:0097706	vascular endothelial cell response to oscillatory fluid shear stress	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome annotation linking PP2A to endothelial cell response to oscillatory shear stress.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	81	R-HSA-9865226	PP2A dephosphorylates serine-127 of YAP1	yes	reactome/R-HSA-9865226.md	PP2A dephosphorylates serine-127 of YAP1	Homo sapiens	GO:0004722	protein serine/threonine phosphatase activity	TAS	enables	MF	false		ACCEPT	PPP2CA is the catalytic subunit of PP2A, a well-established serine/threonine phosphatase (EC 3.1.3.16). This is the core molecular function, supported by extensive biochemical, structural, and genetic evidence.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	143	R-HSA-1295599	SPRY2 translocates to the plasma membrane	yes	reactome/R-HSA-1295599.md	SPRY2 translocates to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	144	R-HSA-1295609	SRC phosphorylates SPRY2 on Y55 and Y227	yes	reactome/R-HSA-1295609.md	SRC phosphorylates SPRY2 on Y55 and Y227	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	145	R-HSA-1295613	SPRY2 binds GRB2	yes	reactome/R-HSA-1295613.md	SPRY2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	146	R-HSA-1295622	SPRY2 binds CBL	yes	reactome/R-HSA-1295622.md	SPRY2 binds CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	147	R-HSA-1295632	PPA2A dephosphorylates SPRY2	yes	reactome/R-HSA-1295632.md	PPA2A dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	148	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	149	R-HSA-2995388	PP2A dephosphorylates BANF1	yes	reactome/R-HSA-2995388.md	PP2A dephosphorylates BANF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	150	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	151	R-HSA-927830	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	yes	reactome/R-HSA-927830.md	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	152	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	153	R-HSA-934559	SPRY2 is phosphorylated by phosphorylated MNK1	yes	reactome/R-HSA-934559.md	SPRY2 is phosphorylated by phosphorylated MNK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	154	R-HSA-9667965	ANKLE2 binds PP2A	yes	reactome/R-HSA-9667965.md	ANKLE2 binds PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CA	genes/human/PPP2CA/PPP2CA-ai-review.yaml	PPP2CA	P67775	NCBITaxon:9606	Homo sapiens	155	R-HSA-9865226	PP2A dephosphorylates serine-127 of YAP1	yes	reactome/R-HSA-9865226.md	PP2A dephosphorylates serine-127 of YAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP2CA localizes to the cytosol, which is a well-established localization for PP2A.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	43	R-HSA-1295599	SPRY2 translocates to the plasma membrane	yes	reactome/R-HSA-1295599.md	SPRY2 translocates to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for SPRY2 translocation to plasma membrane. Places PPP2CB in cytosol as part of Spry regulation of FGF signaling.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	44	R-HSA-1295609	SRC phosphorylates SPRY2 on Y55 and Y227	yes	reactome/R-HSA-1295609.md	SRC phosphorylates SPRY2 on Y55 and Y227	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for SRC phosphorylation of SPRY2. Places PPP2CB in cytosol.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	45	R-HSA-1295613	SPRY2 binds GRB2	yes	reactome/R-HSA-1295613.md	SPRY2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for SPRY2-GRB2 binding. Places PPP2CB in cytosol.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	46	R-HSA-1295622	SPRY2 binds CBL	yes	reactome/R-HSA-1295622.md	SPRY2 binds CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for SPRY2-CBL binding. Places PPP2CB in cytosol.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	47	R-HSA-1295632	PPA2A dephosphorylates SPRY2	yes	reactome/R-HSA-1295632.md	PPA2A dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for PP2A dephosphorylation of SPRY2. This directly reflects PP2A phosphatase activity in the cytosol acting on the SPRY2 substrate.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	48	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for PTPN11 dephosphorylation of SPRY2. Places PPP2CB in cytosol.
human	PPP2CB	genes/human/PPP2CB/PPP2CB-ai-review.yaml	PPP2CB	P62714	NCBITaxon:9606	Homo sapiens	49	R-HSA-934559	SPRY2 is phosphorylated by phosphorylated MNK1	yes	reactome/R-HSA-934559.md	SPRY2 is phosphorylated by phosphorylated MNK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for SPRY2 phosphorylation by MNK1. Places PPP2CB in cytosol.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	94	R-HSA-1295599	SPRY2 translocates to the plasma membrane	yes	reactome/R-HSA-1295599.md	SPRY2 translocates to the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	95	R-HSA-1295609	SRC phosphorylates SPRY2 on Y55 and Y227	yes	reactome/R-HSA-1295609.md	SRC phosphorylates SPRY2 on Y55 and Y227	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	96	R-HSA-1295613	SPRY2 binds GRB2	yes	reactome/R-HSA-1295613.md	SPRY2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	97	R-HSA-1295622	SPRY2 binds CBL	yes	reactome/R-HSA-1295622.md	SPRY2 binds CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	98	R-HSA-1295632	PPA2A dephosphorylates SPRY2	yes	reactome/R-HSA-1295632.md	PPA2A dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	99	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	100	R-HSA-2574840	AJUBA facilitates AURKA autophosphorylation	yes	reactome/R-HSA-2574840.md	AJUBA facilitates AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	101	R-HSA-2574845	AJUBA binds centrosome-associated AURKA	yes	reactome/R-HSA-2574845.md	AJUBA binds centrosome-associated AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	102	R-HSA-2995388	PP2A dephosphorylates BANF1	yes	reactome/R-HSA-2995388.md	PP2A dephosphorylates BANF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	103	R-HSA-3000310	AURKA phosphorylates PLK1	yes	reactome/R-HSA-3000310.md	AURKA phosphorylates PLK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	104	R-HSA-3000319	BORA binds PLK1 and AURKA	yes	reactome/R-HSA-3000319.md	BORA binds PLK1 and AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	105	R-HSA-380272	Plk1-mediated phosphorylation of Nlp	yes	reactome/R-HSA-380272.md	Plk1-mediated phosphorylation of Nlp	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	106	R-HSA-380283	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	yes	reactome/R-HSA-380283.md	Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	107	R-HSA-380294	Loss of C-Nap-1 from centrosomes	yes	reactome/R-HSA-380294.md	Loss of C-Nap-1 from centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	108	R-HSA-380303	Dissociation of Phospho-Nlp from the centrosome	yes	reactome/R-HSA-380303.md	Dissociation of Phospho-Nlp from the centrosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	109	R-HSA-380311	Recruitment of Plk1 to centrosomes	yes	reactome/R-HSA-380311.md	Recruitment of Plk1 to centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	110	R-HSA-380316	Association of NuMA with microtubules	yes	reactome/R-HSA-380316.md	Association of NuMA with microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	111	R-HSA-380455	Recruitment of CDK11p58 to the centrosomes	yes	reactome/R-HSA-380455.md	Recruitment of CDK11p58 to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	112	R-HSA-380508	Translocation of NuMA to the centrosomes	yes	reactome/R-HSA-380508.md	Translocation of NuMA to the centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	113	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	114	R-HSA-5626220	C2CD3 binds the mother centriole	yes	reactome/R-HSA-5626220.md	C2CD3 binds the mother centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	115	R-HSA-5626223	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	yes	reactome/R-HSA-5626223.md	C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	116	R-HSA-5626227	CP110 and CEP97 dissociate from the centriole	yes	reactome/R-HSA-5626227.md	CP110 and CEP97 dissociate from the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	117	R-HSA-5626228	The distal appendage proteins recruit TTBK2	yes	reactome/R-HSA-5626228.md	The distal appendage proteins recruit TTBK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	118	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	119	R-HSA-5626699	MARK4 binds ODF2 in the centriole	yes	reactome/R-HSA-5626699.md	MARK4 binds ODF2 in the centriole	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	120	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	121	R-HSA-8853405	TPX2 binds AURKA at centrosomes	yes	reactome/R-HSA-8853405.md	TPX2 binds AURKA at centrosomes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	122	R-HSA-8853419	TPX2 promotes AURKA autophosphorylation	yes	reactome/R-HSA-8853419.md	TPX2 promotes AURKA autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	123	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	124	R-HSA-927830	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	yes	reactome/R-HSA-927830.md	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	125	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	126	R-HSA-934559	SPRY2 is phosphorylated by phosphorylated MNK1	yes	reactome/R-HSA-934559.md	SPRY2 is phosphorylated by phosphorylated MNK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R1A	genes/human/PPP2R1A/PPP2R1A-ai-review.yaml	PPP2R1A	P30153	NCBITaxon:9606	Homo sapiens	127	R-HSA-9667965	ANKLE2 binds PP2A	yes	reactome/R-HSA-9667965.md	ANKLE2 binds PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome pathway annotation. PPP2R1A is cytosolic as a core component of PP2A holoenzymes involved in various Reactome pathways.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	50	R-HSA-4088141	PP2A-PPP2R2A dephosphorylates FOXM1	yes	reactome/R-HSA-4088141.md	PP2A-PPP2R2A dephosphorylates FOXM1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the B55-alpha-specific dephosphorylation of FOXM1 in the nucleoplasm, implying a nuclear pool of the PP2A-B55-alpha holoenzyme.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	52	R-HSA-2995388	PP2A dephosphorylates BANF1	yes	reactome/R-HSA-2995388.md	PP2A dephosphorylates BANF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places BANF1/BAF dephosphorylation by the PPP2R2A-containing PP2A complex, which initiates nuclear envelope reformation, in the cytosol.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	53	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the SMG5/SMG7/SMG6-mediated recruitment of PP2A to phosphorylated UPF1, a cytosolic NMD step, in the cytosol.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	54	R-HSA-927830	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	yes	reactome/R-HSA-927830.md	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the decay of the SMG5:SMG6:SMG7-bound mRNA, in which PP2A participates, in the cytosol.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	55	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places SMG6-mediated cleavage of the premature-termination-codon mRNA, within the same PP2A-containing complex, in the cytosol.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	56	R-HSA-9667965	ANKLE2 binds PP2A	yes	reactome/R-HSA-9667965.md	ANKLE2 binds PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's ANKLE2-PP2A binding reaction, which uses the B55-alpha-containing complex explicitly, is placed in the cytosol.
human	PPP2R2A	genes/human/PPP2R2A/PPP2R2A-ai-review.yaml	PPP2R2A	P63151	NCBITaxon:9606	Homo sapiens	57	R-HSA-9865226	PP2A dephosphorylates serine-127 of YAP1	yes	reactome/R-HSA-9865226.md	PP2A dephosphorylates serine-127 of YAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places PP2A-mediated dephosphorylation of YAP1 Ser127, downstream of integrin-fibronectin signalling, in the cytosol.
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	101	R-HSA-2025890	Calcineurin binds NFATC1,2,3	yes	reactome/R-HSA-2025890.md	Calcineurin binds NFATC1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	102	R-HSA-2730849	Calcineurin binds and dephosphorylates NFAT	yes	reactome/R-HSA-2730849.md	Calcineurin binds and dephosphorylates NFAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	103	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	104	R-HSA-2730872	Activation of Calcineurin	yes	reactome/R-HSA-2730872.md	Activation of Calcineurin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	105	R-HSA-4551451	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	yes	reactome/R-HSA-4551451.md	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	106	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PPP3CA/calcineurin functions in the cytosol in Ca2+-dependent signaling complexes [PMID:22343722].
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	107	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic context can occur during NFAT-related signaling translocation events (Reactome evidence).
human	PPP3CA	genes/human/PPP3CA/PPP3CA-ai-review.yaml	PPP3CA	Q08209	NCBITaxon:9606	Homo sapiens	108	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic context can occur during NFAT-related signaling translocation events (Reactome evidence).
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	58	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KEEP_AS_NON_CORE. Calcineurin translocates to the nucleus with NFAT (Reactome: Translocation of CaN:CaM:NFAT to nucleus). Not the primary localization.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	59	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	KEEP_AS_NON_CORE. Same as above - calcineurin accompanies NFAT to nucleus (Reactome: Translocation of NFATC1:CaN:CaM to nucleus).
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	60	R-HSA-2025890	Calcineurin binds NFATC1,2,3	yes	reactome/R-HSA-2025890.md	Calcineurin binds NFATC1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Calcineurin binds NFATC1,2,3. Cytosolic localization consistent with experimental data.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	61	R-HSA-2730849	Calcineurin binds and dephosphorylates NFAT	yes	reactome/R-HSA-2730849.md	Calcineurin binds and dephosphorylates NFAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Calcineurin binds and dephosphorylates NFAT.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	62	R-HSA-2730867	Translocation of CaN:CaM:NFAT to nucleus	yes	reactome/R-HSA-2730867.md	Translocation of CaN:CaM:NFAT to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Translocation of CaN:CaM:NFAT to nucleus. Cytosol is the starting location.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	63	R-HSA-2730872	Activation of Calcineurin	yes	reactome/R-HSA-2730872.md	Activation of Calcineurin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Activation of Calcineurin. Occurs in cytosol.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	64	R-HSA-4551451	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	yes	reactome/R-HSA-4551451.md	Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling.
human	PPP3CB	genes/human/PPP3CB/PPP3CB-ai-review.yaml	PPP3CB	P16298	NCBITaxon:9606	Homo sapiens	65	R-HSA-4551465	Translocation of NFATC1:CaN:CaM to nucleus	yes	reactome/R-HSA-4551465.md	Translocation of NFATC1:CaN:CaM to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ACCEPT. Reactome: Translocation of NFATC1:CaN:CaM to nucleus.
human	PRDX4	genes/human/PRDX4/PRDX4-ai-review.yaml	PRDX4	Q13162	NCBITaxon:9606	Homo sapiens	27	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	extracellular region reflects secretory or extracellular detection/pathway context for PRDX4 rather than the main site of its curated peroxidase function.
human	PRDX4	genes/human/PRDX4/PRDX4-ai-review.yaml	PRDX4	Q13162	NCBITaxon:9606	Homo sapiens	28	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	extracellular region reflects secretory or extracellular detection/pathway context for PRDX4 rather than the main site of its curated peroxidase function.
human	PRDX4	genes/human/PRDX4/PRDX4-ai-review.yaml	PRDX4	Q13162	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	secretory granule lumen reflects secretory or extracellular detection/pathway context for PRDX4 rather than the main site of its curated peroxidase function.
human	PRDX4	genes/human/PRDX4/PRDX4-ai-review.yaml	PRDX4	Q13162	NCBITaxon:9606	Homo sapiens	30	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ficolin-1-rich granule lumen reflects secretory or extracellular detection/pathway context for PRDX4 rather than the main site of its curated peroxidase function.
human	PRG2	genes/human/PRG2/PRG2-ai-review.yaml	PRG2	P13727	NCBITaxon:9606	Homo sapiens	18	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region from PMID:8547309 (rat MBP cloning, showing secreted protein).
human	PRG2	genes/human/PRG2/PRG2-ai-review.yaml	PRG2	P13727	NCBITaxon:9606	Homo sapiens	19	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		REMOVE	Ficolin-1-rich granule lumen from Reactome — this is a neutrophil- specific granule type, but MBP is in eosinophil granules, not neutrophils. Per PR #766 review feedback, the prior KEEP_AS_NON_CORE action contradicted the reasoning that calls this a likely annotation error; correct action for an inaccurate annotation is REMOVE.
human	PRG3	genes/human/PRG3/PRG3-ai-review.yaml	PRG3	Q9Y2Y8	NCBITaxon:9606	Homo sapiens	7	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region - PRG3 secreted and functions extracellularly.
human	PRG3	genes/human/PRG3/PRG3-ai-review.yaml	PRG3	Q9Y2Y8	NCBITaxon:9606	Homo sapiens	8	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Extracellular region - PRG3 secreted and functions extracellularly.
human	PRG3	genes/human/PRG3/PRG3-ai-review.yaml	PRG3	Q9Y2Y8	NCBITaxon:9606	Homo sapiens	9	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		ACCEPT	Specific granule lumen - eosinophil secondary granule storage.
human	PRG3	genes/human/PRG3/PRG3-ai-review.yaml	PRG3	Q9Y2Y8	NCBITaxon:9606	Homo sapiens	10	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		REMOVE	Tertiary granule lumen - eosinophils contain specific/secondary granules, not tertiary granules (neutrophil-specific).
human	PRODH	genes/human/PRODH/PRODH-ai-review.yaml	PRODH	O43272	NCBITaxon:9606	Homo sapiens	9	R-HSA-70688	Proline catabolism	yes	reactome/R-HSA-70688.md	Proline catabolism	Homo sapiens	GO:0006562	L-proline catabolic process	TAS	involved_in	BP	false		ACCEPT	"Traceable-author (Reactome ""Proline catabolism"") annotation to the core biological process. Reactome models PRODH as catalyzing the first step of proline breakdown."
human	PRODH	genes/human/PRODH/PRODH-ai-review.yaml	PRODH	O43272	NCBITaxon:9606	Homo sapiens	10	R-HSA-70670	PRODH oxidises L-Pro to 1PYR-5COOH	yes	reactome/R-HSA-70670.md	PRODH oxidises L-Pro to 1PYR-5COOH	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author (Reactome) annotation to the mitochondrial inner membrane. PRODH is tightly bound to the inner mitochondrial membrane, where its FAD passes electrons to ubiquinone in the respiratory chain.
human	PRPS1	genes/human/PRPS1/PRPS1-ai-review.yaml	PRPS1	P60891	NCBITaxon:9606	Homo sapiens	32	R-HSA-111215	PRPS1 dimer pyrophosphorylates R5P using dATP	yes	reactome/R-HSA-111215.md	PRPS1 dimer pyrophosphorylates R5P using dATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing PRPS1 catalysis in the cytosol, the compartment where PRPP synthesis occurs.
human	PRPS1	genes/human/PRPS1/PRPS1-ai-review.yaml	PRPS1	P60891	NCBITaxon:9606	Homo sapiens	33	R-HSA-73580	PRPS dimers pyrophosphorylate R5P using ATP	yes	reactome/R-HSA-73580.md	PRPS dimers pyrophosphorylate R5P using ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author annotation placing the PRPS dimer-catalyzed reaction in the cytosol.
human	PRSS23	genes/human/PRSS23/PRSS23-ai-review.yaml	PRSS23	O95084	NCBITaxon:9606	Homo sapiens	5	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Secretory-pathway transit compartment, asserted because PRSS23 is a FAM20C phosphorylation substrate.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	22	R-HSA-9840334	PSAP is cleaved	yes	reactome/R-HSA-9840334.md	PSAP is cleaved	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from the Reactome reaction in which prosaposin is cleaved. This is the core compartment where prosaposin is processed and the saposins act on glycosphingolipids.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	25	R-HSA-1606312	GLB1 hydrolyzes SapB/C:LacCer	yes	reactome/R-HSA-1606312.md	GLB1 hydrolyzes SapB/C:LacCer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome glycosphingolipid-catabolism reaction (GLB1 hydrolyzes SapB/C:LacCer), where saposin B/C present lipid to the hydrolase. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	26	R-HSA-1605624	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	yes	reactome/R-HSA-1605624.md	Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from the Reactome reaction in which beta-galactosidase hydrolyses saposin-mobilized GM1 to GM2. Core compartment for the activator function.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	27	R-HSA-1605632	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	yes	reactome/R-HSA-1605632.md	bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (bHEXA/bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE), reflecting saposin-B-mediated lipid presentation. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	28	R-HSA-1605724	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	yes	reactome/R-HSA-1605724.md	NEU1,4 hydrolyze PSAP(195-273):GM3:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (NEU1,4 hydrolyze PSAP(195-273):GM3:PE) reflecting saposin-B lipid presentation. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	29	R-HSA-1605736	GLA hydrolyzes PSAP(195-273):Gb3Cer:PE	yes	reactome/R-HSA-1605736.md	GLA hydrolyzes PSAP(195-273):Gb3Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (GLA hydrolyzes PSAP(195-273):Gb3Cer:PE) reflecting saposin-B lipid presentation. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	30	R-HSA-1606807	ARSA removes sulfate from PSAP(195-273):Sulfatide	yes	reactome/R-HSA-1606807.md	ARSA removes sulfate from PSAP(195-273):Sulfatide	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (ARSA removes sulfate from PSAP(195-273):Sulfatide), the canonical saposin-B / arylsulfatase A activation step. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	31	R-HSA-351341	Exocytosis of Proactivator polypeptide	yes	reactome/R-HSA-351341.md	Exocytosis of Proactivator polypeptide	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from the Reactome Exocytosis of Proactivator polypeptide reaction. Prosaposin transits the lysosomal lumen en route through the secretory/endolysosomal system.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	32	R-HSA-9840470	PSAP(195-273) dimer:PE binds and mobilizes ligands	yes	reactome/R-HSA-9840470.md	PSAP(195-273) dimer:PE binds and mobilizes ligands	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (PSAP(195-273) dimer:PE binds and mobilizes ligands), representing saposin-B lipid mobilization in the lumen. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	33	R-HSA-9840488	PSAP(195-273) forms a dimer	yes	reactome/R-HSA-9840488.md	PSAP(195-273) forms a dimer	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (PSAP(195-273) forms a dimer), the saposin-B homodimerization step. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	34	R-HSA-9841189	GLA hydrolyzes PSAP(195-273):Gal2Cer:PE	yes	reactome/R-HSA-9841189.md	GLA hydrolyzes PSAP(195-273):Gal2Cer:PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (GLA hydrolyzes PSAP(195-273):Gal2Cer:PE) reflecting saposin-B lipid presentation. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	35	R-HSA-9842115	PSAP(195-273) dimer binds PE	yes	reactome/R-HSA-9842115.md	PSAP(195-273) dimer binds PE	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Lysosomal lumen localization from a Reactome reaction (PSAP(195-273) dimer binds PE), the saposin-B / phosphatidylethanolamine association step in the lumen. Core compartment.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	60	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization from a Reactome neutrophil-degranulation (azurophil granule exocytosis) reaction. Reflects transient association during secretion of granule contents rather than a stable functional plasma-membrane pool.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	61	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Azurophil granule membrane localization from a Reactome neutrophil-degranulation reaction, reflecting prosaposin cargo in neutrophil secretory granules. Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	65	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from a Reactome Gi-GPCR signalling reaction, reflecting secreted prosaposin acting as an extracellular GPCR ligand (GPR37/GPR37L1). Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	66	R-HSA-5336182	GPR37 binds prosaptide	yes	reactome/R-HSA-5336182.md	GPR37 binds prosaptide	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from the Reactome reaction GPR37 binds prosaptide, i.e. secreted prosaposin/prosaptide engaging its GPCR. Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	67	R-HSA-5336184	GPR37L binds prosaposin	yes	reactome/R-HSA-5336184.md	GPR37L binds prosaposin	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from the Reactome reaction GPR37L binds prosaposin, reflecting secreted prosaposin engaging GPR37L1. Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	68	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from a Reactome Gi-GPCR complex-dissociation reaction, part of the secreted-prosaposin GPCR signalling pathway. Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	69	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from a Reactome ligand-GPCR-Gi binding reaction, part of the secreted prosaposin GPCR signalling pathway. Non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	72	R-HSA-351341	Exocytosis of Proactivator polypeptide	yes	reactome/R-HSA-351341.md	Exocytosis of Proactivator polypeptide	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region from the Reactome Exocytosis of Proactivator polypeptide reaction, reflecting secretion of prosaposin. Consistent with the secreted form; non-core.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	73	R-HSA-1605591	GBA1:SAPC hydrolyzes GlcCer	yes	reactome/R-HSA-1605591.md	GBA1:SAPC hydrolyzes GlcCer	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Lysosomal membrane localization from the Reactome reaction GBA1:SAPC hydrolyzes GlcCer, where saposin C acts at the lysosomal membrane to present glucosylceramide to glucocerebrosidase. Consistent with saposin C membrane association during the core activator reaction.
human	PSAP	genes/human/PSAP/PSAP-ai-review.yaml	PSAP	P07602	NCBITaxon:9606	Homo sapiens	74	R-HSA-9840334	PSAP is cleaved	yes	reactome/R-HSA-9840334.md	PSAP is cleaved	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Lysosomal membrane localization from the Reactome reaction PSAP is cleaved, reflecting the membrane-associated processing/action of prosaposin and saposins in the lysosome. Consistent with the lysosomal site of function.
human	PSAT1	genes/human/PSAT1/PSAT1-ai-review.yaml	PSAT1	Q9Y617	NCBITaxon:9606	Homo sapiens	15	R-HSA-977333	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA	yes	reactome/R-HSA-977333.md	PXLP-K200-PSAT1 dimer transfers amino group from L-Glu to 3POPA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable statement placing the PSAT1-catalyzed transamination in the cytosol. Consistent with the HPA IDA localization; accurate subcellular location.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	134	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	135	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	136	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	137	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	138	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	139	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	140	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	141	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	142	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	143	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	144	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Subcellular localization consistent with PSEN1/gamma-secretase trafficking and activity in secretory, endosomal, and plasma-membrane compartments.
human	PSEN1	genes/human/PSEN1/PSEN1-ai-review.yaml	PSEN1	P49768	NCBITaxon:9606	Homo sapiens	160	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		UNDECIDED	Evidence is not sufficient in the cached materials to decide whether this annotation should be retained for PSEN1.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	55	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	56	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	57	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	58	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	59	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	60	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	61	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	62	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	63	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSEN2	genes/human/PSEN2/PSEN2-ai-review.yaml	PSEN2	P49810	NCBITaxon:9606	Homo sapiens	64	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane localization is a plausible gamma-secretase context, but PSEN2 is much less abundant at the cell surface than PSEN1 in later comparative studies.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	47	R-HSA-9010096	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	yes	reactome/R-HSA-9010096.md	Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	56	R-HSA-1251997	Cleavage of ERBB4m80 by gamma-scretase complex	yes	reactome/R-HSA-1251997.md	Cleavage of ERBB4m80 by gamma-scretase complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	57	R-HSA-193682	gamma-secretase cleaves the p75NTR transmembrane domain	yes	reactome/R-HSA-193682.md	gamma-secretase cleaves the p75NTR transmembrane domain	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	58	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	59	R-HSA-2220988	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	yes	reactome/R-HSA-2220988.md	NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	60	R-HSA-3928656	gamma-secretase cleaves EPHB2	yes	reactome/R-HSA-3928656.md	gamma-secretase cleaves EPHB2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	61	R-HSA-9013361	NEXT3 is cleaved to produce NICD3	yes	reactome/R-HSA-9013361.md	NEXT3 is cleaved to produce NICD3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	62	R-HSA-9017817	Gamma-secretase cleaves YBX1:NOTCH3	yes	reactome/R-HSA-9017817.md	Gamma-secretase cleaves YBX1:NOTCH3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	63	R-HSA-9839376	TGFBR3(784-851) degradation	yes	reactome/R-HSA-9839376.md	TGFBR3(784-851) degradation	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	64	R-NUL-2197556	Gamma-secretase complex cleaves mNEXT2	yes	reactome/R-NUL-2197556.md	Gamma-secretase complex cleaves mNEXT2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSENEN	genes/human/PSENEN/PSENEN-ai-review.yaml	PSENEN	Q9NZ42	NCBITaxon:9606	Homo sapiens	65	R-NUL-9604300	Gamma-secretase cleaves Notch4	yes	reactome/R-NUL-9604300.md	Gamma-secretase cleaves Notch4	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	This membrane or endomembrane location is consistent with PSENEN/PEN-2 as a multipass gamma-secretase subunit in ER, Golgi, cell-membrane, and substrate-processing compartments.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	93	R-HSA-1168640	Ubiquitinated IkB is degraded	yes	reactome/R-HSA-1168640.md	Ubiquitinated IkB is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	94	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	95	R-HSA-1236970	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	yes	reactome/R-HSA-1236970.md	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	96	R-HSA-1504193	Ubiquitinated DVL is degraded by the proteasome	yes	reactome/R-HSA-1504193.md	Ubiquitinated DVL is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	97	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	98	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	99	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	100	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	101	R-HSA-180573	Degradation of ubiquitinated CD4	yes	reactome/R-HSA-180573.md	Degradation of ubiquitinated CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	102	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	103	R-HSA-209061	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	yes	reactome/R-HSA-209061.md	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	104	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	105	R-HSA-264458	Proteasome mediated degradation of COP1	yes	reactome/R-HSA-264458.md	Proteasome mediated degradation of COP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	106	R-HSA-353125	26S proteosome degrades ODC holoenzyme complex	yes	reactome/R-HSA-353125.md	26S proteosome degrades ODC holoenzyme complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	107	R-HSA-3640874	Ub-RibC-AXIN is degraded by the proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	108	R-HSA-450466	AUF1:mRNA complex is degraded	yes	reactome/R-HSA-450466.md	AUF1:mRNA complex is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	109	R-HSA-4608855	PRICKLE1 is degraded by the proteasome	yes	reactome/R-HSA-4608855.md	PRICKLE1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	110	R-HSA-4641256	Ubiquitinated AXIN is degraded by the proteasome	yes	reactome/R-HSA-4641256.md	Ubiquitinated AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	111	R-HSA-4641260	Ubiquitinated DVL1 is degraded by the proteasome	yes	reactome/R-HSA-4641260.md	Ubiquitinated DVL1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	112	R-HSA-5362448	Hh C-terminal fragments are degraded by the proteasome	yes	reactome/R-HSA-5362448.md	Hh C-terminal fragments are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	113	R-HSA-5387392	processing defective Hh variants are degraded by the proteasome	yes	reactome/R-HSA-5387392.md	processing defective Hh variants are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	114	R-HSA-5607724	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	yes	reactome/R-HSA-5607724.md	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	115	R-HSA-5607731	26S proteasome processes p-7S-p100:RELB to form p52:RELB	yes	reactome/R-HSA-5607731.md	26S proteasome processes p-7S-p100:RELB to form p52:RELB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	116	R-HSA-5610754	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	yes	reactome/R-HSA-5610754.md	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	117	R-HSA-5610758	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	yes	reactome/R-HSA-5610758.md	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	118	R-HSA-5610760	GLI1 is degraded by the proteasome after ubiquitination by ITCH	yes	reactome/R-HSA-5610760.md	GLI1 is degraded by the proteasome after ubiquitination by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	119	R-HSA-5635868	ub-GLI is degraded by the proteasome	yes	reactome/R-HSA-5635868.md	ub-GLI is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	120	R-HSA-5658430	NF1 is degraded by the proteasome	yes	reactome/R-HSA-5658430.md	NF1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	121	R-HSA-5665854	ADRM1:26S proteaseome binds UCHL5	yes	reactome/R-HSA-5665854.md	ADRM1:26S proteaseome binds UCHL5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	122	R-HSA-5665871	ADRM1 binds 26S proteasome	yes	reactome/R-HSA-5665871.md	ADRM1 binds 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	123	R-HSA-5668481	Protesomal degradation of K48polyUb-TRAF3	yes	reactome/R-HSA-5668481.md	Protesomal degradation of K48polyUb-TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	124	R-HSA-5668520	26Sproteasome degrades K48polyUb-NIK	yes	reactome/R-HSA-5668520.md	26Sproteasome degrades K48polyUb-NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	125	R-HSA-5687112	MAPK6 is degraded by the 26S proteasome	yes	reactome/R-HSA-5687112.md	MAPK6 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	126	R-HSA-5689539	ADRM1:26S proteaseome binds USP14	yes	reactome/R-HSA-5689539.md	ADRM1:26S proteaseome binds USP14	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	127	R-HSA-68948	Ubiquitinated Orc1 is degraded by the proteasome	yes	reactome/R-HSA-68948.md	Ubiquitinated Orc1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	128	R-HSA-69016	Ubiquitinated Cdc6 is degraded by the proteasome	yes	reactome/R-HSA-69016.md	Ubiquitinated Cdc6 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	129	R-HSA-75825	Proteasome mediated degradation of Cyclin D1	yes	reactome/R-HSA-75825.md	Proteasome mediated degradation of Cyclin D1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	130	R-HSA-8850992	Proteasome degrades polyubiquitinated PTEN	yes	reactome/R-HSA-8850992.md	Proteasome degrades polyubiquitinated PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	131	R-HSA-8852354	GTSE1 facilitates proteasome-mediated degradation of TP53	yes	reactome/R-HSA-8852354.md	GTSE1 facilitates proteasome-mediated degradation of TP53	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	132	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	133	R-HSA-8854071	Proteasome-mediated degradation of PolyUb-FBXL7	yes	reactome/R-HSA-8854071.md	Proteasome-mediated degradation of PolyUb-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	134	R-HSA-8866553	misfolded CFTR is degraded by the 26S proteasome	yes	reactome/R-HSA-8866553.md	misfolded CFTR is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	135	R-HSA-8866858	CFTR F508del is degraded by the 26S proteasome	yes	reactome/R-HSA-8866858.md	CFTR F508del is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	136	R-HSA-8932355	26S proteasome degrades Ub-NFE2L2	yes	reactome/R-HSA-8932355.md	26S proteasome degrades Ub-NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	137	R-HSA-8956140	NEDD8 and UBD bind NUB1 and the 26S proteasome	yes	reactome/R-HSA-8956140.md	NEDD8 and UBD bind NUB1 and the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	138	R-HSA-8956184	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	yes	reactome/R-HSA-8956184.md	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	139	R-HSA-8957265	26S proteasome degrades TP73 polyubiquitinated by ITCH	yes	reactome/R-HSA-8957265.md	26S proteasome degrades TP73 polyubiquitinated by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	140	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	141	R-HSA-9755306	ub UBXN7 is degraded by the 26S proteasome	yes	reactome/R-HSA-9755306.md	ub UBXN7 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	142	R-HSA-9766223	Proteasome-dependent degradation of ubiquitinated CDH1	yes	reactome/R-HSA-9766223.md	Proteasome-dependent degradation of ubiquitinated CDH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	143	R-HSA-983150	Proteasomal cleavage of substrate	yes	reactome/R-HSA-983150.md	Proteasomal cleavage of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	144	R-HSA-9907898	Formation of the inner ring of the 20S core particle of the 26S proteasome	yes	reactome/R-HSA-9907898.md	Formation of the inner ring of the 20S core particle of the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	145	R-HSA-9907912	Formation of the outer ring of the 20S core particle	yes	reactome/R-HSA-9907912.md	Formation of the outer ring of the 20S core particle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	146	R-HSA-9907919	Formation of the preholoproteasome	yes	reactome/R-HSA-9907919.md	Formation of the preholoproteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	147	R-HSA-9907925	Formation of the inner ring of the 20S immunoproteasome core particle	yes	reactome/R-HSA-9907925.md	Formation of the inner ring of the 20S immunoproteasome core particle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	148	R-HSA-9907928	Formation of the inner ring of the 20S thymoproteasome core particle	yes	reactome/R-HSA-9907928.md	Formation of the inner ring of the 20S thymoproteasome core particle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	149	R-HSA-9907940	Formation of the preholothymoproteasome	yes	reactome/R-HSA-9907940.md	Formation of the preholothymoproteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	150	R-HSA-9907941	Fromation of the preholoimmunoproteasome	yes	reactome/R-HSA-9907941.md	Fromation of the preholoimmunoproteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	151	R-HSA-9908052	PSMG1:PSMG2 dimer binds the 20S core particle outer ring	yes	reactome/R-HSA-9908052.md	PSMG1:PSMG2 dimer binds the 20S core particle outer ring	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	152	R-HSA-9908069	POMP binds the 20S core particle outer ring	yes	reactome/R-HSA-9908069.md	POMP binds the 20S core particle outer ring	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	153	R-HSA-9908101	Maturation of the canonical 20S core particle	yes	reactome/R-HSA-9908101.md	Maturation of the canonical 20S core particle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	154	R-HSA-9908178	Formation of the 26S proteasome	yes	reactome/R-HSA-9908178.md	Formation of the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	155	R-HSA-9908709	Formation of the PA28-alpha-beta-20S proteasome	yes	reactome/R-HSA-9908709.md	Formation of the PA28-alpha-beta-20S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	156	R-HSA-9908721	Formation of the PA28gamma-20S proteasome	yes	reactome/R-HSA-9908721.md	Formation of the PA28gamma-20S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	157	R-HSA-9912636	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	yes	reactome/R-HSA-9912636.md	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	158	R-HSA-9912655	Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)	yes	reactome/R-HSA-9912655.md	Proteasomal cleavage of intracellular substrate (immunoproteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	159	R-HSA-9912747	Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)	yes	reactome/R-HSA-9912747.md	Proteasomal clevage of exogenous antigen (immunoproteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	160	R-HSA-9912751	Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)	yes	reactome/R-HSA-9912751.md	Proteasomal cleavage of partially digested antigen (immunoproteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	161	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	162	R-HSA-9929486	SPOP-mediated degradation of CD274 by 26S Proteosome	yes	reactome/R-HSA-9929486.md	SPOP-mediated degradation of CD274 by 26S Proteosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	163	R-HSA-9931314	Proteasomal degradation of polyUb-p-S195-CD274	yes	reactome/R-HSA-9931314.md	Proteasomal degradation of polyUb-p-S195-CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	164	R-HSA-9934893	Proteolysis of K48polyUb-K,p-S-PER1,2,3	yes	reactome/R-HSA-9934893.md	Proteolysis of K48polyUb-K,p-S-PER1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	165	R-HSA-9954728	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	yes	reactome/R-HSA-9954728.md	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	166	R-NUL-212917	Proteasome mediated degradation of PAK-2p34	yes	reactome/R-NUL-212917.md	Proteasome mediated degradation of PAK-2p34	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	167	R-NUL-5610751	Gli2is degraded by the proteasome	yes	reactome/R-NUL-5610751.md	Gli2is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	168	R-NUL-9011324	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	yes	reactome/R-NUL-9011324.md	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	Caenorhabditis elegans	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMA1.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	178	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	179	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	180	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	181	R-HSA-5635854	GLI2,3 are degraded by the proteasome	yes	reactome/R-HSA-5635854.md	GLI2,3 are degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	182	R-HSA-68825	Ubiquitinated geminin is degraded by the proteasome	yes	reactome/R-HSA-68825.md	Ubiquitinated geminin is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	183	R-HSA-69600	Proteolytic degradation of ubiquitinated-Cdc25A	yes	reactome/R-HSA-69600.md	Proteolytic degradation of ubiquitinated-Cdc25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	184	R-HSA-8939801	26S proteasome degrades PolyUb-RUNX2	yes	reactome/R-HSA-8939801.md	26S proteasome degrades PolyUb-RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	185	R-HSA-8952408	Polyubiquitinated RUNX3 is degraded by the proteasome	yes	reactome/R-HSA-8952408.md	Polyubiquitinated RUNX3 is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	186	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMA1	genes/human/PSMA1/PSMA1-ai-review.yaml	PSMA1	P25786	NCBITaxon:9606	Homo sapiens	187	R-NUL-9604648	Proteasome degrades ubiquitinated mouse NICD4	yes	reactome/R-NUL-9604648.md	Proteasome degrades ubiquitinated mouse NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	62	R-HSA-9912633	Antigen processing: Ub, ATP-independent proteasomal degradation	yes	reactome/R-HSA-9912633.md	Antigen processing: Ub, ATP-independent proteasomal degradation	Homo sapiens	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	TAS	involved_in	BP	false		ACCEPT	proteasomal ubiquitin-independent protein catabolic process captures the proteasome-mediated protein catabolism process supported for this subunit as part of the proteasome.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	63	R-HSA-9907900	Proteasome assembly	yes	reactome/R-HSA-9907900.md	Proteasome assembly	Homo sapiens	GO:0043248	proteasome assembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	PSMB5 maturation and incorporation are relevant to proteasome biogenesis, but assembly is not the mature subunit catalytic function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	66	R-HSA-9912636	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	yes	reactome/R-HSA-9912636.md	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	Homo sapiens	GO:0004175	endopeptidase activity	TAS	enables	MF	false		MODIFY	endopeptidase activity is directionally related to the proteasome role but is less specific than the supported proteasome term.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	67	R-HSA-9908101	Maturation of the canonical 20S core particle	yes	reactome/R-HSA-9908101.md	Maturation of the canonical 20S core particle	Homo sapiens	GO:0004175	endopeptidase activity	TAS	enables	MF	false		MODIFY	endopeptidase activity is directionally related to the proteasome role but is less specific than the supported proteasome term.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	68	R-HSA-1168640	Ubiquitinated IkB is degraded	yes	reactome/R-HSA-1168640.md	Ubiquitinated IkB is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	69	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	70	R-HSA-1236970	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	yes	reactome/R-HSA-1236970.md	Proteasomal clevage of exogenous antigen (26S proteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	71	R-HSA-1504193	Ubiquitinated DVL is degraded by the proteasome	yes	reactome/R-HSA-1504193.md	Ubiquitinated DVL is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	72	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	73	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	74	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	75	R-HSA-174255	Degradation multiubiquitinated Cyclin A	yes	reactome/R-HSA-174255.md	Degradation multiubiquitinated Cyclin A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	76	R-HSA-180573	Degradation of ubiquitinated CD4	yes	reactome/R-HSA-180573.md	Degradation of ubiquitinated CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	77	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	78	R-HSA-209061	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	yes	reactome/R-HSA-209061.md	Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	79	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	80	R-HSA-264458	Proteasome mediated degradation of COP1	yes	reactome/R-HSA-264458.md	Proteasome mediated degradation of COP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	81	R-HSA-353125	26S proteosome degrades ODC holoenzyme complex	yes	reactome/R-HSA-353125.md	26S proteosome degrades ODC holoenzyme complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	82	R-HSA-3640874	Ub-RibC-AXIN is degraded by the proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	83	R-HSA-450466	AUF1:mRNA complex is degraded	yes	reactome/R-HSA-450466.md	AUF1:mRNA complex is degraded	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	84	R-HSA-4608855	PRICKLE1 is degraded by the proteasome	yes	reactome/R-HSA-4608855.md	PRICKLE1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	85	R-HSA-4641256	Ubiquitinated AXIN is degraded by the proteasome	yes	reactome/R-HSA-4641256.md	Ubiquitinated AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	86	R-HSA-4641260	Ubiquitinated DVL1 is degraded by the proteasome	yes	reactome/R-HSA-4641260.md	Ubiquitinated DVL1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	87	R-HSA-5362448	Hh C-terminal fragments are degraded by the proteasome	yes	reactome/R-HSA-5362448.md	Hh C-terminal fragments are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	88	R-HSA-5387392	processing defective Hh variants are degraded by the proteasome	yes	reactome/R-HSA-5387392.md	processing defective Hh variants are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	89	R-HSA-5607724	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	yes	reactome/R-HSA-5607724.md	26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	90	R-HSA-5607731	26S proteasome processes p-7S-p100:RELB to form p52:RELB	yes	reactome/R-HSA-5607731.md	26S proteasome processes p-7S-p100:RELB to form p52:RELB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	91	R-HSA-5610754	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	yes	reactome/R-HSA-5610754.md	GLI3 is partially degraded by the proteasome to yield the GLI3 repressor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	92	R-HSA-5610758	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	yes	reactome/R-HSA-5610758.md	GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	93	R-HSA-5610760	GLI1 is degraded by the proteasome after ubiquitination by ITCH	yes	reactome/R-HSA-5610760.md	GLI1 is degraded by the proteasome after ubiquitination by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	94	R-HSA-5635868	ub-GLI is degraded by the proteasome	yes	reactome/R-HSA-5635868.md	ub-GLI is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	95	R-HSA-5658430	NF1 is degraded by the proteasome	yes	reactome/R-HSA-5658430.md	NF1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	96	R-HSA-5665854	ADRM1:26S proteaseome binds UCHL5	yes	reactome/R-HSA-5665854.md	ADRM1:26S proteaseome binds UCHL5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	97	R-HSA-5665871	ADRM1 binds 26S proteasome	yes	reactome/R-HSA-5665871.md	ADRM1 binds 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	98	R-HSA-5668481	Protesomal degradation of K48polyUb-TRAF3	yes	reactome/R-HSA-5668481.md	Protesomal degradation of K48polyUb-TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	99	R-HSA-5668520	26Sproteasome degrades K48polyUb-NIK	yes	reactome/R-HSA-5668520.md	26Sproteasome degrades K48polyUb-NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	100	R-HSA-5687112	MAPK6 is degraded by the 26S proteasome	yes	reactome/R-HSA-5687112.md	MAPK6 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	101	R-HSA-5689539	ADRM1:26S proteaseome binds USP14	yes	reactome/R-HSA-5689539.md	ADRM1:26S proteaseome binds USP14	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	102	R-HSA-68948	Ubiquitinated Orc1 is degraded by the proteasome	yes	reactome/R-HSA-68948.md	Ubiquitinated Orc1 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	103	R-HSA-69016	Ubiquitinated Cdc6 is degraded by the proteasome	yes	reactome/R-HSA-69016.md	Ubiquitinated Cdc6 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	104	R-HSA-75825	Proteasome mediated degradation of Cyclin D1	yes	reactome/R-HSA-75825.md	Proteasome mediated degradation of Cyclin D1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	105	R-HSA-8850992	Proteasome degrades polyubiquitinated PTEN	yes	reactome/R-HSA-8850992.md	Proteasome degrades polyubiquitinated PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	106	R-HSA-8852354	GTSE1 facilitates proteasome-mediated degradation of TP53	yes	reactome/R-HSA-8852354.md	GTSE1 facilitates proteasome-mediated degradation of TP53	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	107	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	108	R-HSA-8854071	Proteasome-mediated degradation of PolyUb-FBXL7	yes	reactome/R-HSA-8854071.md	Proteasome-mediated degradation of PolyUb-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	109	R-HSA-8866553	misfolded CFTR is degraded by the 26S proteasome	yes	reactome/R-HSA-8866553.md	misfolded CFTR is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	110	R-HSA-8866858	CFTR F508del is degraded by the 26S proteasome	yes	reactome/R-HSA-8866858.md	CFTR F508del is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	111	R-HSA-8932355	26S proteasome degrades Ub-NFE2L2	yes	reactome/R-HSA-8932355.md	26S proteasome degrades Ub-NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	112	R-HSA-8956140	NEDD8 and UBD bind NUB1 and the 26S proteasome	yes	reactome/R-HSA-8956140.md	NEDD8 and UBD bind NUB1 and the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	113	R-HSA-8956184	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	yes	reactome/R-HSA-8956184.md	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	114	R-HSA-8957265	26S proteasome degrades TP73 polyubiquitinated by ITCH	yes	reactome/R-HSA-8957265.md	26S proteasome degrades TP73 polyubiquitinated by ITCH	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	115	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	116	R-HSA-9755306	ub UBXN7 is degraded by the 26S proteasome	yes	reactome/R-HSA-9755306.md	ub UBXN7 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	117	R-HSA-9766223	Proteasome-dependent degradation of ubiquitinated CDH1	yes	reactome/R-HSA-9766223.md	Proteasome-dependent degradation of ubiquitinated CDH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	118	R-HSA-983150	Proteasomal cleavage of substrate	yes	reactome/R-HSA-983150.md	Proteasomal cleavage of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	119	R-HSA-9907898	Formation of the inner ring of the 20S core particle of the 26S proteasome	yes	reactome/R-HSA-9907898.md	Formation of the inner ring of the 20S core particle of the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	120	R-HSA-9907919	Formation of the preholoproteasome	yes	reactome/R-HSA-9907919.md	Formation of the preholoproteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	121	R-HSA-9908101	Maturation of the canonical 20S core particle	yes	reactome/R-HSA-9908101.md	Maturation of the canonical 20S core particle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	122	R-HSA-9908178	Formation of the 26S proteasome	yes	reactome/R-HSA-9908178.md	Formation of the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	123	R-HSA-9908709	Formation of the PA28-alpha-beta-20S proteasome	yes	reactome/R-HSA-9908709.md	Formation of the PA28-alpha-beta-20S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	124	R-HSA-9908721	Formation of the PA28gamma-20S proteasome	yes	reactome/R-HSA-9908721.md	Formation of the PA28gamma-20S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	125	R-HSA-9912636	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	yes	reactome/R-HSA-9912636.md	Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	126	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	127	R-HSA-9929486	SPOP-mediated degradation of CD274 by 26S Proteosome	yes	reactome/R-HSA-9929486.md	SPOP-mediated degradation of CD274 by 26S Proteosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	128	R-HSA-9931314	Proteasomal degradation of polyUb-p-S195-CD274	yes	reactome/R-HSA-9931314.md	Proteasomal degradation of polyUb-p-S195-CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	129	R-HSA-9934893	Proteolysis of K48polyUb-K,p-S-PER1,2,3	yes	reactome/R-HSA-9934893.md	Proteolysis of K48polyUb-K,p-S-PER1,2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	130	R-HSA-9954728	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	yes	reactome/R-HSA-9954728.md	The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	131	R-NUL-212917	Proteasome mediated degradation of PAK-2p34	yes	reactome/R-NUL-212917.md	Proteasome mediated degradation of PAK-2p34	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	132	R-NUL-5610751	Gli2is degraded by the proteasome	yes	reactome/R-NUL-5610751.md	Gli2is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	133	R-NUL-9011324	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	yes	reactome/R-NUL-9011324.md	Proteasome degrades SAX-3 ubiquitinated by EBAX-1	Caenorhabditis elegans	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core cellular context for the assembled proteasome containing PSMB5.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	142	R-HSA-174058	Degradation of multiubiquitinated Cdh1	yes	reactome/R-HSA-174058.md	Degradation of multiubiquitinated Cdh1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	143	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	144	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	145	R-HSA-5635854	GLI2,3 are degraded by the proteasome	yes	reactome/R-HSA-5635854.md	GLI2,3 are degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	146	R-HSA-68825	Ubiquitinated geminin is degraded by the proteasome	yes	reactome/R-HSA-68825.md	Ubiquitinated geminin is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	147	R-HSA-69600	Proteolytic degradation of ubiquitinated-Cdc25A	yes	reactome/R-HSA-69600.md	Proteolytic degradation of ubiquitinated-Cdc25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	148	R-HSA-8939801	26S proteasome degrades PolyUb-RUNX2	yes	reactome/R-HSA-8939801.md	26S proteasome degrades PolyUb-RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	149	R-HSA-8952408	Polyubiquitinated RUNX3 is degraded by the proteasome	yes	reactome/R-HSA-8952408.md	Polyubiquitinated RUNX3 is degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	150	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSMB5	genes/human/PSMB5/PSMB5-ai-review.yaml	PSMB5	P28074	NCBITaxon:9606	Homo sapiens	151	R-NUL-9604648	Proteasome degrades ubiquitinated mouse NICD4	yes	reactome/R-NUL-9604648.md	Proteasome degrades ubiquitinated mouse NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm is a supported localization or active-location annotation for proteasomes but not the gene-specific core function.
human	PSPH	genes/human/PSPH/PSPH-ai-review.yaml	PSPH	P78330	NCBITaxon:9606	Homo sapiens	22	R-HSA-977324	PSPH:Mg2+ dimer dephosphorylates O-P-Ser	yes	reactome/R-HSA-977324.md	PSPH:Mg2+ dimer dephosphorylates O-P-Ser	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author statement placing the PSPH:Mg2+ dimer reaction (dephosphorylation of O-phospho-L-serine) in the cytosol. Consistent with the experimental cytosol localization. Kept as non-core location.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	55	R-HSA-1660499	Synthesis of PIPs at the plasma membrane	yes	reactome/R-HSA-1660499.md	Synthesis of PIPs at the plasma membrane	Homo sapiens	GO:0006661	phosphatidylinositol biosynthetic process	TAS	involved_in	BP	false		MODIFY	PTEN is involved in phosphatidylinositol metabolism by dephosphorylating 3-phosphorylated phosphoinositides, but this is catabolism not biosynthesis.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	56	R-HSA-199456	PTEN dephosphorylates PIP3	yes	reactome/R-HSA-199456.md	PTEN dephosphorylates PIP3	Homo sapiens	GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS	involved_in	BP	false		ACCEPT	PTEN negatively regulates PI3K/AKT signaling by dephosphorylating PIP3. This is a core process annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	57	R-HSA-199456	PTEN dephosphorylates PIP3	yes	reactome/R-HSA-199456.md	PTEN dephosphorylates PIP3	Homo sapiens	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	TAS	enables	MF	false		ACCEPT	PTEN's primary enzymatic activity. Duplicate of IBA and IDA annotations.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	67	R-HSA-1676149	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane	yes	reactome/R-HSA-1676149.md	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane	Homo sapiens	GO:0051800	phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	TAS	enables	MF	false		ACCEPT	PI(3,4)P2 3-phosphatase activity is documented for PTEN. Duplicate of IEA annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	95	R-HSA-5689950	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN	yes	reactome/R-HSA-5689950.md	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation. PTEN localizes to nucleoplasm.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	96	R-HSA-6807118	USP7 deubiquitinates monoubiquitinated PTEN	yes	reactome/R-HSA-6807118.md	USP7 deubiquitinates monoubiquitinated PTEN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	97	R-HSA-6807126	Deubiquitinated PTEN translocates to the cytosol	yes	reactome/R-HSA-6807126.md	Deubiquitinated PTEN translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	101	R-HSA-2317387	PTEN cancer mutants do not dephosphorylate PIP3	yes	reactome/R-HSA-2317387.md	PTEN cancer mutants do not dephosphorylate PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	114	R-HSA-1676149	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane	yes	reactome/R-HSA-1676149.md	PI(3,4)P2 is dephosphorylated to PI4P by PTEN at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	115	R-HSA-1855205	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol	yes	reactome/R-HSA-1855205.md	I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	116	R-HSA-199456	PTEN dephosphorylates PIP3	yes	reactome/R-HSA-199456.md	PTEN dephosphorylates PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	117	R-HSA-2321904	PTEN mRNA translation negatively regulated by microRNAs	yes	reactome/R-HSA-2321904.md	PTEN mRNA translation negatively regulated by microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	118	R-HSA-6807106	PTEN undergoes monoubiquitination	yes	reactome/R-HSA-6807106.md	PTEN undergoes monoubiquitination	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	119	R-HSA-6807126	Deubiquitinated PTEN translocates to the cytosol	yes	reactome/R-HSA-6807126.md	Deubiquitinated PTEN translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	120	R-HSA-6807134	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN	yes	reactome/R-HSA-6807134.md	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	121	R-HSA-6807206	USP13 and OTUD3 deubiquitinate PTEN	yes	reactome/R-HSA-6807206.md	USP13 and OTUD3 deubiquitinate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	122	R-HSA-8847968	PTEN binds FRK	yes	reactome/R-HSA-8847968.md	PTEN binds FRK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	123	R-HSA-8847977	FRK phosphorylates PTEN	yes	reactome/R-HSA-8847977.md	FRK phosphorylates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	124	R-HSA-8850945	Casein kinase II phosphorylates PTEN	yes	reactome/R-HSA-8850945.md	Casein kinase II phosphorylates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	125	R-HSA-8850961	PREX2 binds PTEN and inhibits it	yes	reactome/R-HSA-8850961.md	PREX2 binds PTEN and inhibits it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	128	R-HSA-6807105	Monoubiquitinated PTEN translocates to the nucleus	yes	reactome/R-HSA-6807105.md	Monoubiquitinated PTEN translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	129	R-HSA-6807105	Monoubiquitinated PTEN translocates to the nucleus	yes	reactome/R-HSA-6807105.md	Monoubiquitinated PTEN translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	185	R-HSA-8850992	Proteasome degrades polyubiquitinated PTEN	yes	reactome/R-HSA-8850992.md	Proteasome degrades polyubiquitinated PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	186	R-HSA-8850997	TRIM27 binds PTEN	yes	reactome/R-HSA-8850997.md	TRIM27 binds PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	187	R-HSA-8851011	TRIM27 polyubiquitinates PTEN	yes	reactome/R-HSA-8851011.md	TRIM27 polyubiquitinates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	188	R-HSA-8873946	OTUD3 deubiquitinates PTEN	yes	reactome/R-HSA-8873946.md	OTUD3 deubiquitinates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	189	R-HSA-8944497	PTEN mRNA translation is negatively regulated by microRNAs	yes	reactome/R-HSA-8944497.md	PTEN mRNA translation is negatively regulated by microRNAs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	190	R-HSA-8948775	MKRN1 polyubiquitinates PTEN	yes	reactome/R-HSA-8948775.md	MKRN1 polyubiquitinates PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	191	R-HSA-8948800	TNKS and TNKS2 PARylate PTEN	yes	reactome/R-HSA-8948800.md	TNKS and TNKS2 PARylate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	192	R-HSA-8948832	RNF146 polyubiquitinates PARylated PTEN	yes	reactome/R-HSA-8948832.md	RNF146 polyubiquitinates PARylated PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTEN	genes/human/PTEN/PTEN-ai-review.yaml	PTEN	P60484	NCBITaxon:9606	Homo sapiens	193	R-HSA-9615571	PTEN mRNA translation is inhibited by miR-137	yes	reactome/R-HSA-9615571.md	PTEN mRNA translation is inhibited by miR-137	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	31	R-HSA-2162123	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	yes	reactome/R-HSA-2162123.md	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Homo sapiens	GO:0046457	prostanoid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	TAS annotation for prostanoid biosynthetic process from Reactome pathway R-HSA-2162123 (Synthesis of Prostaglandins and Thromboxanes). PTGES3 catalyzes the conversion of PGH2 to PGE2 as part of this pathway.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	50	R-HSA-5082409	Dissociation of HSF1:HSP90 complex in the nucleus	yes	reactome/R-HSA-5082409.md	Dissociation of HSF1:HSP90 complex in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome pathway R-HSA-5082409 (Dissociation of HSF1:HSP90 complex in the nucleus). PTGES3 is part of the HSP90 complex that dissociates from HSF1 in the nucleus.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	51	R-HSA-5324617	HSP90:FKBP4:PTGES3 binds HSF1 trimer	yes	reactome/R-HSA-5324617.md	HSP90:FKBP4:PTGES3 binds HSF1 trimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-5324617 (HSP90:FKBP4:PTGES3 binds HSF1 trimer).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	52	R-HSA-5618080	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-5618080 (HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	53	R-HSA-5618093	ATP hydrolysis by HSP90	yes	reactome/R-HSA-5618093.md	ATP hydrolysis by HSP90	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-5618093 (ATP hydrolysis by HSP90).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	54	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-8937169 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm). PTGES3 is part of the aryl hydrocarbon receptor complex that translocates to the nucleus.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	55	R-HSA-8937191	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	yes	reactome/R-HSA-8937191.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-8937191 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	56	R-HSA-8939203	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex	yes	reactome/R-HSA-8939203.md	HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-8939203 (HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	57	R-HSA-8939204	ESTG binds ESR1:chaperone complex	yes	reactome/R-HSA-8939204.md	ESTG binds ESR1:chaperone complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-8939204 (ESTG binds ESR1:chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	58	R-HSA-9032751	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3	yes	reactome/R-HSA-9032751.md	Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-9032751 (Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	59	R-HSA-9038161	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG	yes	reactome/R-HSA-9038161.md	Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-9038161 (Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	60	R-HSA-9709547	ESTG binds ESR2:chaperone complex	yes	reactome/R-HSA-9709547.md	ESTG binds ESR2:chaperone complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-9709547 (ESTG binds ESR2:chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	61	R-HSA-9716913	ESR1 binds ESR1 antagonists	yes	reactome/R-HSA-9716913.md	ESR1 binds ESR1 antagonists	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-9716913 (ESR1 binds ESR1 antagonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	62	R-HSA-9716947	ESR1 binds ESR1 agonists	yes	reactome/R-HSA-9716947.md	ESR1 binds ESR1 agonists	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasm from Reactome R-HSA-9716947 (ESR1 binds ESR1 agonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	63	R-HSA-265295	Prostaglandin E synthase isomerizes PGH2 to PGE2	yes	reactome/R-HSA-265295.md	Prostaglandin E synthase isomerizes PGH2 to PGE2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-265295 (Prostaglandin E synthase isomerizes PGH2 to PGE2). PTGES3 catalyzes PGE2 synthesis in the cytosol.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	64	R-HSA-3371586	Dissociation of cytosolic HSF1:HSP90 complex	yes	reactome/R-HSA-3371586.md	Dissociation of cytosolic HSF1:HSP90 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-3371586 (Dissociation of cytosolic HSF1:HSP90 complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	65	R-HSA-5324632	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	yes	reactome/R-HSA-5324632.md	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5324632 (Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	66	R-HSA-5618073	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein	yes	reactome/R-HSA-5618073.md	FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5618073 (FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	67	R-HSA-5618080	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	yes	reactome/R-HSA-5618080.md	HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5618080 (HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	68	R-HSA-5618098	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5618098 (p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein). PTGES3 binds to the HSP90 complex in the cytosol.
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	69	R-HSA-5618099	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)	yes	reactome/R-HSA-5618099.md	NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5618099 (NR3C2 ligands bind NR3C2 in the HSP90 chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	70	R-HSA-5618110	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-5618110 (p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	71	R-HSA-8936849	AHR:2xHSP90:AIP:PTGES3 binds TCDD	yes	reactome/R-HSA-8936849.md	AHR:2xHSP90:AIP:PTGES3 binds TCDD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-8936849 (AHR:2xHSP90:AIP:PTGES3 binds TCDD).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	72	R-HSA-8937169	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8937169.md	AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-8937169 (AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	73	R-HSA-9678925	NR3C1 binds NR3C1 agonists	yes	reactome/R-HSA-9678925.md	NR3C1 binds NR3C1 agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9678925 (NR3C1 binds NR3C1 agonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	74	R-HSA-9690534	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)	yes	reactome/R-HSA-9690534.md	NR3C1 ligands bind NR3C1 (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9690534 (NR3C1 ligands bind NR3C1 in the HSP90 chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	75	R-HSA-9705925	Androgens binds AR (in the HSP90 chaperone complex)	yes	reactome/R-HSA-9705925.md	Androgens binds AR (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9705925 (Androgens bind AR in the HSP90 chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	76	R-HSA-9705926	AR binds AR agonists	yes	reactome/R-HSA-9705926.md	AR binds AR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9705926 (AR binds AR agonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	77	R-HSA-9706837	AR binds AR antagonists	yes	reactome/R-HSA-9706837.md	AR binds AR antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9706837 (AR binds AR antagonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	78	R-HSA-9725855	NR3C2 binds NR3C2 antagonists	yes	reactome/R-HSA-9725855.md	NR3C2 binds NR3C2 antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9725855 (NR3C2 binds NR3C2 antagonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	79	R-HSA-9725885	P4 bind PGR (in the HSP90 chaperone complex)	yes	reactome/R-HSA-9725885.md	P4 bind PGR (in the HSP90 chaperone complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9725885 (P4 binds PGR in the HSP90 chaperone complex).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	80	R-HSA-9726509	NR3C2 binds fludrocortisone	yes	reactome/R-HSA-9726509.md	NR3C2 binds fludrocortisone	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9726509 (NR3C2 binds fludrocortisone).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	81	R-HSA-9726580	PGR binds PGR agonists	yes	reactome/R-HSA-9726580.md	PGR binds PGR agonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9726580 (PGR binds PGR agonists).
human	PTGES3	genes/human/PTGES3/PTGES3-ai-review.yaml	PTGES3	Q15185	NCBITaxon:9606	Homo sapiens	82	R-HSA-9726621	PGR binds PGR antagonists	yes	reactome/R-HSA-9726621.md	PGR binds PGR antagonists	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation for cytosol from Reactome R-HSA-9726621 (PGR binds PGR antagonists).
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	88	R-HSA-177929	Signaling by EGFR	yes	reactome/R-HSA-177929.md	Signaling by EGFR	Homo sapiens	GO:0007173	epidermal growth factor receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SHP2 participates in epidermal-growth-factor-receptor signaling.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	89	R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	yes	reactome/R-HSA-512988.md	Interleukin-3, Interleukin-5 and GM-CSF signaling	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SHP2 participates in multiple cytokine-receptor signaling pathways.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	90	R-HSA-9674555	Signaling by CSF3 (G-CSF)	yes	reactome/R-HSA-9674555.md	Signaling by CSF3 (G-CSF)	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SHP2 participates in multiple cytokine-receptor signaling pathways.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	91	R-HSA-388841	Regulation of T cell activation by CD28 family	yes	reactome/R-HSA-388841.md	Regulation of T cell activation by CD28 family	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SHP2 participates in T-cell costimulatory and coinhibitory receptor networks.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	92	R-HSA-912694	Regulation of IFNA/IFNB signaling	yes	reactome/R-HSA-912694.md	Regulation of IFNA/IFNB signaling	Homo sapiens	GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SHP2 regulates type-I-interferon signaling in innate-immune contexts.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	95	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine phosphatase activity is the established catalytic activity of SHP2.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	96	R-HSA-389758	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	yes	reactome/R-HSA-389758.md	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine phosphatase activity is the established catalytic activity of SHP2.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	97	R-HSA-914036	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	yes	reactome/R-HSA-914036.md	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine phosphatase activity is the established catalytic activity of SHP2.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	98	R-HSA-997309	Dephosphorylation of STAT1 by SHP2	yes	reactome/R-HSA-997309.md	Dephosphorylation of STAT1 by SHP2	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Protein tyrosine phosphatase activity is the established catalytic activity of SHP2.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	114	R-HSA-177923	Sustained activation of SRC kinase by SHP2	yes	reactome/R-HSA-177923.md	Sustained activation of SRC kinase by SHP2	Homo sapiens	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Non-membrane-spanning protein tyrosine phosphatase activity is SHP2's defining catalytic function.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	115	R-HSA-177924	Dephosphorylation of Gab1 by SHP2	yes	reactome/R-HSA-177924.md	Dephosphorylation of Gab1 by SHP2	Homo sapiens	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Non-membrane-spanning protein tyrosine phosphatase activity is SHP2's defining catalytic function.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	116	R-HSA-177926	Dephosphorylation of PAG by SHP2	yes	reactome/R-HSA-177926.md	Dephosphorylation of PAG by SHP2	Homo sapiens	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Non-membrane-spanning protein tyrosine phosphatase activity is SHP2's defining catalytic function.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	117	R-HSA-177935	SHP2 dephosphorylates Tyr 992 on EGFR	yes	reactome/R-HSA-177935.md	SHP2 dephosphorylates Tyr 992 on EGFR	Homo sapiens	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	Non-membrane-spanning protein tyrosine phosphatase activity is SHP2's defining catalytic function.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	122	R-HSA-8937744	PTPN11 binds p-7Y-RUNX1	yes	reactome/R-HSA-8937744.md	PTPN11 binds p-7Y-RUNX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome event Reactome:R-HSA-8937744 places SHP2 in the nucleoplasm in a specific nuclear signaling context.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	123	R-HSA-8937767	PTPN11 dephosphorylates RUNX1	yes	reactome/R-HSA-8937767.md	PTPN11 dephosphorylates RUNX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome event Reactome:R-HSA-8937767 places SHP2 in the nucleoplasm in a specific nuclear signaling context.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	124	R-HSA-9008894	PTPNs gene transcription and translation	yes	reactome/R-HSA-9008894.md	PTPNs gene transcription and translation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome event Reactome:R-HSA-9008894 places SHP2 in the nucleoplasm in a specific nuclear signaling context.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	125	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome event Reactome:R-HSA-9698016 places SHP2 in the nucleoplasm in a specific nuclear signaling context.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	126	R-HSA-9698021	PTPN11:p-STAT5 binds BCL2L1 promoter	yes	reactome/R-HSA-9698021.md	PTPN11:p-STAT5 binds BCL2L1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome event Reactome:R-HSA-9698021 places SHP2 in the nucleoplasm in a specific nuclear signaling context.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	127	R-HSA-109699	PI3K-containing complexes phosphorylate PIP2 to PIP3	yes	reactome/R-HSA-109699.md	PI3K-containing complexes phosphorylate PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-109699 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	128	R-HSA-1112690	PTPN11 binds CBL	yes	reactome/R-HSA-1112690.md	PTPN11 binds CBL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1112690 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	129	R-HSA-1112703	PTPN11 is phosphorylated	yes	reactome/R-HSA-1112703.md	PTPN11 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1112703 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	130	R-HSA-1112708	PTPN11 binds p-Y759-IL6ST	yes	reactome/R-HSA-1112708.md	PTPN11 binds p-Y759-IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1112708 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	131	R-HSA-1433428	GRB2 is indirectly recruited to p-KIT through SHP2	yes	reactome/R-HSA-1433428.md	GRB2 is indirectly recruited to p-KIT through SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1433428 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	132	R-HSA-1433454	Phosphorylation of GAB2 by SFKs	yes	reactome/R-HSA-1433454.md	Phosphorylation of GAB2 by SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1433454 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	133	R-HSA-1433488	Phosphorylation of SHP2 by SFKs	yes	reactome/R-HSA-1433488.md	Phosphorylation of SHP2 by SFKs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1433488 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	134	R-HSA-1433514	Synthesis of PIP3 from PIP2 by PI3K	yes	reactome/R-HSA-1433514.md	Synthesis of PIP3 from PIP2 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1433514 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	135	R-HSA-1549564	PPTN11 dephosphorylates SPRY2	yes	reactome/R-HSA-1549564.md	PPTN11 dephosphorylates SPRY2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1549564 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	136	R-HSA-1562641	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	yes	reactome/R-HSA-1562641.md	Indirect recruitment of PI3K to KIT via p(Y)-GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-1562641 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	137	R-HSA-177923	Sustained activation of SRC kinase by SHP2	yes	reactome/R-HSA-177923.md	Sustained activation of SRC kinase by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-177923 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	138	R-HSA-177924	Dephosphorylation of Gab1 by SHP2	yes	reactome/R-HSA-177924.md	Dephosphorylation of Gab1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-177924 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	139	R-HSA-177926	Dephosphorylation of PAG by SHP2	yes	reactome/R-HSA-177926.md	Dephosphorylation of PAG by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-177926 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	140	R-HSA-177935	SHP2 dephosphorylates Tyr 992 on EGFR	yes	reactome/R-HSA-177935.md	SHP2 dephosphorylates Tyr 992 on EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-177935 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	141	R-HSA-177944	Activation of SHP2 through the binding to phospho-Gab1	yes	reactome/R-HSA-177944.md	Activation of SHP2 through the binding to phospho-Gab1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-177944 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	142	R-HSA-186778	SHP2 binds to the active receptor	yes	reactome/R-HSA-186778.md	SHP2 binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-186778 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	143	R-HSA-204873	Interaction of Tie2 and Shp2	yes	reactome/R-HSA-204873.md	Interaction of Tie2 and Shp2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-204873 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	144	R-HSA-205234	Indirect recruitment of GAB2 to p-KIT	yes	reactome/R-HSA-205234.md	Indirect recruitment of GAB2 to p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-205234 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	145	R-HSA-205238	SHP2 interacts with p-KIT	yes	reactome/R-HSA-205238.md	SHP2 interacts with p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-205238 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	146	R-HSA-210294	Interaction of PECAM-1 and SHP-2	yes	reactome/R-HSA-210294.md	Interaction of PECAM-1 and SHP-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-210294 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	147	R-HSA-2316434	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2316434.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-2316434 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	148	R-HSA-2400009	PI3K inhibitors block PI3K catalytic activity	yes	reactome/R-HSA-2400009.md	PI3K inhibitors block PI3K catalytic activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-2400009 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	149	R-HSA-388829	SHP2 phosphatase binds CTLA-4	yes	reactome/R-HSA-388829.md	SHP2 phosphatase binds CTLA-4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-388829 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	150	R-HSA-389758	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	yes	reactome/R-HSA-389758.md	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-389758 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	151	R-HSA-389759	Interaction of SHP-1 or SHP-2 with phospho PD-1	yes	reactome/R-HSA-389759.md	Interaction of SHP-1 or SHP-2 with phospho PD-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-389759 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	152	R-HSA-389941	SHP-1 and SHP-2 bind pBTLA	yes	reactome/R-HSA-389941.md	SHP-1 and SHP-2 bind pBTLA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-389941 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	153	R-HSA-5654584	Activated FGFR1:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654584.md	Activated FGFR1:p-FRS bind to PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654584 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	154	R-HSA-5654587	Activated FGFR1:p-FRS phosphorylates PPTN11	yes	reactome/R-HSA-5654587.md	Activated FGFR1:p-FRS phosphorylates PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654587 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	155	R-HSA-5654594	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654594.md	Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654594 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	156	R-HSA-5654596	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654596.md	Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654596 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	157	R-HSA-5654607	Activated FGFR2 phosphorylates PPTN11	yes	reactome/R-HSA-5654607.md	Activated FGFR2 phosphorylates PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654607 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	158	R-HSA-5654608	Activated FGFR2:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654608.md	Activated FGFR2:p-FRS bind to PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654608 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	159	R-HSA-5654620	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654620.md	Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654620 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	160	R-HSA-5654622	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654622.md	Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654622 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	161	R-HSA-5654631	Activated FGFR3 phosphorylates PPTN11	yes	reactome/R-HSA-5654631.md	Activated FGFR3 phosphorylates PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654631 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	162	R-HSA-5654633	Activated FGFR3:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654633.md	Activated FGFR3:p-FRS bind to PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654633 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	163	R-HSA-5654641	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654641.md	Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654641 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	164	R-HSA-5654643	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	yes	reactome/R-HSA-5654643.md	Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654643 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	165	R-HSA-5654655	Activated FGFR4 phosphorylates PPTN11	yes	reactome/R-HSA-5654655.md	Activated FGFR4 phosphorylates PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654655 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	166	R-HSA-5654658	Activated FGFR4:p-FRS bind to PPTN11	yes	reactome/R-HSA-5654658.md	Activated FGFR4:p-FRS bind to PPTN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654658 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	167	R-HSA-5654667	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	yes	reactome/R-HSA-5654667.md	Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654667 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	168	R-HSA-5654669	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	yes	reactome/R-HSA-5654669.md	Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654669 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	169	R-HSA-5654672	CBL ubiquitinates FRS2 and FGFR1	yes	reactome/R-HSA-5654672.md	CBL ubiquitinates FRS2 and FGFR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654672 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	170	R-HSA-5654673	p-CBL:GRB2 binds p-FRS2:activated FGFR1	yes	reactome/R-HSA-5654673.md	p-CBL:GRB2 binds p-FRS2:activated FGFR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654673 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	171	R-HSA-5654677	CBL ubiquitinates FRS2 and FGFR2	yes	reactome/R-HSA-5654677.md	CBL ubiquitinates FRS2 and FGFR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654677 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	172	R-HSA-5654679	CBL ubiquitinates FRS2 and FGFR3	yes	reactome/R-HSA-5654679.md	CBL ubiquitinates FRS2 and FGFR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654679 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	173	R-HSA-5654684	CBL ubiquitinates FRS2 and FGFR4	yes	reactome/R-HSA-5654684.md	CBL ubiquitinates FRS2 and FGFR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654684 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	174	R-HSA-5654692	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654692.md	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654692 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	175	R-HSA-5654697	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654697.md	FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654697 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	176	R-HSA-5654709	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654709.md	FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654709 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	177	R-HSA-5654714	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5654714.md	FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654714 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	178	R-HSA-5654729	p-CBL:GRB2 binds p-FRS2:activated FGFR2	yes	reactome/R-HSA-5654729.md	p-CBL:GRB2 binds p-FRS2:activated FGFR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654729 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	179	R-HSA-5654730	p-CBL:GRB2 binds p-FRS2:activated FGFR3	yes	reactome/R-HSA-5654730.md	p-CBL:GRB2 binds p-FRS2:activated FGFR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654730 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	180	R-HSA-5654734	p-CBL:GRB2 binds p-FRS2:activated FGFR4	yes	reactome/R-HSA-5654734.md	p-CBL:GRB2 binds p-FRS2:activated FGFR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5654734 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	181	R-HSA-5684169	G6B binds PTPN6,PTPN11	yes	reactome/R-HSA-5684169.md	G6B binds PTPN6,PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-5684169 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	182	R-HSA-8855508	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11	yes	reactome/R-HSA-8855508.md	p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8855508 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	183	R-HSA-8865994	GAB1 binds PTPN11	yes	reactome/R-HSA-8865994.md	GAB1 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8865994 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	184	R-HSA-8987014	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	yes	reactome/R-HSA-8987014.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8987014 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	185	R-HSA-8987070	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987070.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8987070 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	186	R-HSA-8987132	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	yes	reactome/R-HSA-8987132.md	IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8987132 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	187	R-HSA-8987236	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-8987236.md	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-8987236 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	188	R-HSA-909738	SHP1 and SHP2 bind the common beta chain	yes	reactome/R-HSA-909738.md	SHP1 and SHP2 bind the common beta chain	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-909738 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	189	R-HSA-914036	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	yes	reactome/R-HSA-914036.md	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-914036 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	190	R-HSA-9674816	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	yes	reactome/R-HSA-9674816.md	p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9674816 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	191	R-HSA-9698005	FLT3 ITD mutants phosphorylate STAT5	yes	reactome/R-HSA-9698005.md	FLT3 ITD mutants phosphorylate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698005 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	192	R-HSA-9698007	FLT3 ITD mutants bind STAT5 through GAB2:PTPN11	yes	reactome/R-HSA-9698007.md	FLT3 ITD mutants bind STAT5 through GAB2:PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698007 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	193	R-HSA-9698008	FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11	yes	reactome/R-HSA-9698008.md	FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698008 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	194	R-HSA-9698013	PTPN11:p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698013.md	PTPN11:p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698013 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	195	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698016 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	196	R-HSA-9698029	p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698029.md	p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-9698029 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN11	genes/human/PTPN11/PTPN11-ai-review.yaml	PTPN11	Q06124	NCBITaxon:9606	Homo sapiens	197	R-HSA-997309	Dephosphorylation of STAT1 by SHP2	yes	reactome/R-HSA-997309.md	Dephosphorylation of STAT1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome event Reactome:R-HSA-997309 places SHP2 in the cytosol, consistent with its soluble receptor-proximal role.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	17	R-HSA-202403	TCR signaling	yes	reactome/R-HSA-202403.md	TCR signaling	Homo sapiens	GO:0050852	T cell receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TAS annotation from Reactome TCR signaling pathway. PTPN22 participates in phosphorylation of CD3 and TCR zeta chains and translocation of ZAP-70 to the immunological synapse.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	18	R-HSA-8852200	Inactivation of LCK by PTPN22	yes	reactome/R-HSA-8852200.md	Inactivation of LCK by PTPN22	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome (Inactivation of LCK by PTPN22). This reflects the specific dephosphorylation of LCK by PTPN22 in the context of TCR signaling.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	19	R-HSA-8855381	PTPN22 dephosphorylates ZAP70	yes	reactome/R-HSA-8855381.md	PTPN22 dephosphorylates ZAP70	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome (PTPN22 dephosphorylates ZAP70). This reflects the specific dephosphorylation of ZAP-70 at Tyr-493 by PTPN22.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	23	R-HSA-8852200	Inactivation of LCK by PTPN22	yes	reactome/R-HSA-8852200.md	Inactivation of LCK by PTPN22	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (Inactivation of LCK by PTPN22). PTPN22 is a cytosolic phosphatase that is recruited to membrane-proximal signaling complexes.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	24	R-HSA-8855375	PTPN22 dissociates from CSK	yes	reactome/R-HSA-8855375.md	PTPN22 dissociates from CSK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (PTPN22 dissociates from CSK). Consistent with cytosolic localization of PTPN22.
human	PTPN22	genes/human/PTPN22/PTPN22-ai-review.yaml	PTPN22	Q9Y2R2	NCBITaxon:9606	Homo sapiens	25	R-HSA-8855381	PTPN22 dephosphorylates ZAP70	yes	reactome/R-HSA-8855381.md	PTPN22 dephosphorylates ZAP70	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (PTPN22 dephosphorylates ZAP70). Consistent with cytosolic localization.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	67	R-HSA-512988	Interleukin-3, Interleukin-5 and GM-CSF signaling	yes	reactome/R-HSA-512988.md	Interleukin-3, Interleukin-5 and GM-CSF signaling	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	cytokine-mediated signaling pathway is supported as a cytokine/JAK-STAT signaling context for SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	68	R-HSA-388841	Regulation of T cell activation by CD28 family	yes	reactome/R-HSA-388841.md	Regulation of T cell activation by CD28 family	Homo sapiens	GO:0031295	T cell costimulation	TAS	involved_in	BP	false		ACCEPT	T cell costimulation is supported in T-cell receptor/costimulation contexts.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	69	R-HSA-912694	Regulation of IFNA/IFNB signaling	yes	reactome/R-HSA-912694.md	Regulation of IFNA/IFNB signaling	Homo sapiens	GO:0060338	regulation of type I interferon-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	regulation of type I interferon-mediated signaling pathway is supported as a cytokine/JAK-STAT signaling context for SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	70	R-HSA-389758	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	yes	reactome/R-HSA-389758.md	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	protein tyrosine phosphatase activity is the core catalytic activity of PTPN6/SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	71	R-HSA-914036	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	yes	reactome/R-HSA-914036.md	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	protein tyrosine phosphatase activity is the core catalytic activity of PTPN6/SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	72	R-HSA-9701507	PTPN6 dephosphorylates JAK3	yes	reactome/R-HSA-9701507.md	PTPN6 dephosphorylates JAK3	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	protein tyrosine phosphatase activity is the core catalytic activity of PTPN6/SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	73	R-HSA-997314	Dephosphorylation of JAK1 by SHP1	yes	reactome/R-HSA-997314.md	Dephosphorylation of JAK1 by SHP1	Homo sapiens	GO:0004725	protein tyrosine phosphatase activity	TAS	enables	MF	false		ACCEPT	protein tyrosine phosphatase activity is the core catalytic activity of PTPN6/SHP-1.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	102	R-HSA-9008894	PTPNs gene transcription and translation	yes	reactome/R-HSA-9008894.md	PTPNs gene transcription and translation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm localization is plausible but secondary to the main cytosolic/receptor-complex role.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	104	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	extracellular region is likely a context-specific or high-throughput localization and not a core SHP-1 site of action.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	105	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	extracellular region is likely a context-specific or high-throughput localization and not a core SHP-1 site of action.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	106	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	specific granule lumen is likely a context-specific or high-throughput localization and not a core SHP-1 site of action.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	107	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	tertiary granule lumen is likely a context-specific or high-throughput localization and not a core SHP-1 site of action.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	115	R-HSA-205306	Interaction of SHP1 and KIT	yes	reactome/R-HSA-205306.md	Interaction of SHP1 and KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	116	R-HSA-210277	Interaction of PECAM-1 and SHP-1	yes	reactome/R-HSA-210277.md	Interaction of PECAM-1 and SHP-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	117	R-HSA-389758	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	yes	reactome/R-HSA-389758.md	Dephosphorylation of CD3-zeta by PD-1 bound phosphatases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	118	R-HSA-389759	Interaction of SHP-1 or SHP-2 with phospho PD-1	yes	reactome/R-HSA-389759.md	Interaction of SHP-1 or SHP-2 with phospho PD-1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	119	R-HSA-389941	SHP-1 and SHP-2 bind pBTLA	yes	reactome/R-HSA-389941.md	SHP-1 and SHP-2 bind pBTLA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	120	R-HSA-5684169	G6B binds PTPN6,PTPN11	yes	reactome/R-HSA-5684169.md	G6B binds PTPN6,PTPN11	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	121	R-HSA-5690701	SHP1 binds p-CD22	yes	reactome/R-HSA-5690701.md	SHP1 binds p-CD22	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	122	R-HSA-909738	SHP1 and SHP2 bind the common beta chain	yes	reactome/R-HSA-909738.md	SHP1 and SHP2 bind the common beta chain	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	123	R-HSA-913424	The SHC1:SHIP1 complex is stabilized by GRB2	yes	reactome/R-HSA-913424.md	The SHC1:SHIP1 complex is stabilized by GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	124	R-HSA-914036	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	yes	reactome/R-HSA-914036.md	SHP1 and SHP2 dephosphorylate Y628 of IL3RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	125	R-HSA-9701507	PTPN6 dephosphorylates JAK3	yes	reactome/R-HSA-9701507.md	PTPN6 dephosphorylates JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	126	R-HSA-9851072	DNMT1-dependent PTPN6 gene silencing	yes	reactome/R-HSA-9851072.md	DNMT1-dependent PTPN6 gene silencing	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPN6	genes/human/PTPN6/PTPN6-ai-review.yaml	PTPN6	P29350	NCBITaxon:9606	Homo sapiens	127	R-HSA-997314	Dephosphorylation of JAK1 by SHP1	yes	reactome/R-HSA-997314.md	Dephosphorylation of JAK1 by SHP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is a core localization for cytosolic non-receptor SHP-1 activity.
human	PTPRN2	genes/human/PTPRN2/PTPRN2-ai-review.yaml	PTPRN2	Q92932	NCBITaxon:9606	Homo sapiens	4	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane: PTPRN2 is a secretory-vesicle membrane protein that traffics to the plasma membrane and regulates neuroendocrine secretion. Its vesicle role is supported independently of any protein tyrosine phosphatase claim.
human	PTPRN2	genes/human/PTPRN2/PTPRN2-ai-review.yaml	PTPRN2	Q92932	NCBITaxon:9606	Homo sapiens	21	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		UNDECIDED	ficolin-1-rich granule membrane: The available evidence examined for PTPRN2 does not resolve the exact claim of ficolin-1-rich granule membrane. The specific experiment or traced orthology/phylogenetic inference behind Reactome:R-HSA-6800426 is needed; the annotation is not rejected from absence in a summary or from a different main focus of the paper.
human	PTS	genes/human/PTS/PTS-ai-review.yaml	PTS	Q03393	NCBITaxon:9606	Homo sapiens	25	R-HSA-1475422	PTPS is phosphorylated by cGMP-dependant protein kinase II	yes	reactome/R-HSA-1475422.md	PTPS is phosphorylated by cGMP-dependant protein kinase II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation based on the PTPS phosphorylation reaction occurring in the cytosol.
human	PTS	genes/human/PTS/PTS-ai-review.yaml	PTS	Q03393	NCBITaxon:9606	Homo sapiens	26	R-HSA-1474184	DHNTP is dephosphorylated by PTPS to PTHP	yes	reactome/R-HSA-1474184.md	DHNTP is dephosphorylated by PTPS to PTHP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for the PTPS catalytic reaction occurring in cytosol.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	19	R-HSA-174088	Association of cell cycle proteins with the APC/C:Cdh1 complex	yes	reactome/R-HSA-174088.md	Association of cell cycle proteins with the APC/C:Cdh1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places PTTG1 in a cytosolic APC/C:Cdh1 substrate-association reaction.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	20	R-HSA-174105	Degradation of multiubiquitinated cell cycle proteins	yes	reactome/R-HSA-174105.md	Degradation of multiubiquitinated cell cycle proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places APC/C-multiubiquitinated cell-cycle-protein degradation, including PTTG1 turnover, in the cytosol.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	21	R-HSA-174121	Association of Securin with Cdc20:APC/C complex	yes	reactome/R-HSA-174121.md	Association of Securin with Cdc20:APC/C complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome models cytosolic recognition of securin by the CDC20-APC/C complex through its destruction motifs.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	22	R-HSA-174144	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	yes	reactome/R-HSA-174144.md	Ubiquitination of Securin by phospho-APC/C:Cdc20 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places APC/C:Cdc20-mediated PTTG1 ubiquitination in the cytosol.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	23	R-HSA-174195	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	yes	reactome/R-HSA-174195.md	Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	The Reactome APC/C:Cdh1 ubiquitination reaction explicitly occurs in the cytosol.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	24	R-HSA-174202	Degradation of multiubiquitinated Securin	yes	reactome/R-HSA-174202.md	Degradation of multiubiquitinated Securin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places proteasomal degradation of multiubiquitinated securin in the cytosol.
human	PTTG1	genes/human/PTTG1/PTTG1-ai-review.yaml	PTTG1	O95997	NCBITaxon:9606	Homo sapiens	25	R-HSA-2467798	PTTG1 (Securin) sequesters ESPL1 (Separase)	yes	reactome/R-HSA-2467798.md	PTTG1 (Securin) sequesters ESPL1 (Separase)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome models cytosolic sequestration of ESPL1 by PTTG1 before anaphase.
human	PUS3	genes/human/PUS3/PUS3-ai-review.yaml	PUS3	Q9BZE2	NCBITaxon:9606	Homo sapiens	15	R-HSA-8870289	PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA	yes	reactome/R-HSA-8870289.md	PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA	Homo sapiens	GO:0006400	tRNA modification	TAS	involved_in	BP	false		ACCEPT	PUS3 performs tRNA modification through pseudouridylation at positions 38/39. This Reactome-based annotation is well-curated and accurate.
human	PUS3	genes/human/PUS3/PUS3-ai-review.yaml	PUS3	Q9BZE2	NCBITaxon:9606	Homo sapiens	19	R-HSA-8870289	PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA	yes	reactome/R-HSA-8870289.md	PUS3 isomerizes uridine-39 to pseudouridine-39 in tRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	PUS3 localizes to the cytosol where it modifies cytosolic tRNAs. This Reactome-based annotation is consistent with other localization data.
human	PYCR1	genes/human/PYCR1/PYCR1-ai-review.yaml	PYCR1	P32322	NCBITaxon:9606	Homo sapiens	20	R-HSA-70664	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro	yes	reactome/R-HSA-70664.md	PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author-statement placing the PYCR1 decamer reaction in the mitochondrial matrix, consistent with the mitochondrial localization established experimentally. Appropriate and more specific than ""mitochondrion""; accept."
human	PYCR2	genes/human/PYCR2/PYCR2-ai-review.yaml	PYCR2	Q96C36	NCBITaxon:9606	Homo sapiens	11	R-HSA-6783939	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro	yes	reactome/R-HSA-6783939.md	PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol location asserted by Reactome, consistent with the erythrocyte enzyme (cytosolic) but not with the mitochondrial localization established for PYCR2 in nucleated cells by isozyme-resolved fractionation and disease studies. Kept as non-core; the core location is mitochondrion.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Assigned via a Reactome neutrophil-degranulation/secretory-granule exocytosis module. PYGL is a cytosolic glycogenolytic enzyme; its presence in the extracellular region reflects secretome/degranulation cataloguing rather than a site of function.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	20	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Same as the other extracellular-region assignment, from a Reactome ficolin-rich granule exocytosis module. Not a functional location for this cytosolic enzyme.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	From a Reactome secretory-granule exocytosis module. PYGL is cytosolic; granule-lumen localization is a bystander proteomic/degranulation catalog assignment, not a functional site.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	22	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	From a Reactome ficolin-rich granule exocytosis module. As with the other granule/extracellular assignments, this is a bystander catalog location, not the functional site of the cytosolic enzyme.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	25	R-HSA-453339	poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol assignment for the glycogenolysis reaction (glycogen + phosphate to glucose-1-phosphate). This is the correct functional location for PYGL.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	26	R-HSA-71588	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	yes	reactome/R-HSA-71588.md	glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol assignment for the phosphorylase b to a interconversion reaction. Correct functional location.
human	PYGL	genes/human/PYGL/PYGL-ai-review.yaml	PYGL	P06737	NCBITaxon:9606	Homo sapiens	27	R-HSA-71590	glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol assignment for glycogen limit-dextrin formation with release of glucose-1-phosphate. Correct functional location.
human	PYGM	genes/human/PYGM/PYGM-ai-review.yaml	PYGM	P11217	NCBITaxon:9606	Homo sapiens	21	R-HSA-453338	PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization of the PYGM b dimer (AMP-complex reaction). Correct localization for this soluble glycogenolytic enzyme.
human	PYGM	genes/human/PYGM/PYGM-ai-review.yaml	PYGM	P11217	NCBITaxon:9606	Homo sapiens	22	R-HSA-453342	PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization of the PYGM b dimer (AMP-binding reaction). Correct localization.
human	PYGM	genes/human/PYGM/PYGM-ai-review.yaml	PYGM	P11217	NCBITaxon:9606	Homo sapiens	23	R-HSA-71541	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	yes	reactome/R-HSA-71541.md	glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization of PYGM associated with its phosphorylation (b to a conversion) by the cytosolic phosphorylase kinase complex.
human	QDPR	genes/human/QDPR/QDPR-ai-review.yaml	QDPR	P09417	NCBITaxon:9606	Homo sapiens	13	R-HSA-71130	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from Reactome, which curates the DHPR reaction (q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+) in the cytosol. This is the physiologically relevant compartment for BH4 salvage.
human	QPRT	genes/human/QPRT/QPRT-ai-review.yaml	QPRT	Q15274	NCBITaxon:9606	Homo sapiens	10	R-HSA-197268	QPRT transfers PRIB to QUIN to form NAMN	yes	reactome/R-HSA-197268.md	QPRT transfers PRIB to QUIN to form NAMN	Homo sapiens	GO:0034354	'de novo' NAD+ biosynthetic process from L-tryptophan	TAS	involved_in	BP	false		ACCEPT	Reactome-traceable assignment of QPRT to de novo NAD+ biosynthesis from L-tryptophan. This is the most specific and accurate biological process for QPRT, placing it at the final committed step converting quinolinate to NaMN.
human	QPRT	genes/human/QPRT/QPRT-ai-review.yaml	QPRT	Q15274	NCBITaxon:9606	Homo sapiens	19	R-HSA-197268	QPRT transfers PRIB to QUIN to form NAMN	yes	reactome/R-HSA-197268.md	QPRT transfers PRIB to QUIN to form NAMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization, consistent with QPRT being a soluble metabolic enzyme of the cytosolic de novo NAD+ pathway. Correct core location.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	37	R-HSA-8870469	RGGT geranylgeranylates RAB proteins	yes	reactome/R-HSA-8870469.md	RGGT geranylgeranylates RAB proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, the GDI-bound soluble pool of a prenylated Rab.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	38	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane, the donor compartment for the step RAB1B controls.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	39	R-HSA-6811427	COPI vesicle uncoating at the ER	yes	reactome/R-HSA-6811427.md	COPI vesicle uncoating at the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane, the donor compartment for the step RAB1B controls.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	40	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	41	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	42	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	43	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	44	R-HSA-6811423	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	yes	reactome/R-HSA-6811423.md	Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	45	R-HSA-6811426	Retrograde COPI vesicles bind kinesin and microtubules	yes	reactome/R-HSA-6811426.md	Retrograde COPI vesicles bind kinesin and microtubules	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Transport vesicle, from six Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	46	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	47	R-HSA-6807864	RAB1:GTP recruits GBF1 to the ERGIC	yes	reactome/R-HSA-6807864.md	RAB1:GTP recruits GBF1 to the ERGIC	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	48	R-HSA-6807866	GBF1 recruits ARF:GDP to the ERGIC	yes	reactome/R-HSA-6807866.md	GBF1 recruits ARF:GDP to the ERGIC	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	49	R-HSA-6807868	GBF1 stimulates ARF nucleotide exchange	yes	reactome/R-HSA-6807868.md	GBF1 stimulates ARF nucleotide exchange	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	50	R-HSA-6807872	Active ARF recruits coatomer	yes	reactome/R-HSA-6807872.md	Active ARF recruits coatomer	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	51	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	52	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	53	R-HSA-6814831	TBC1D20 binds RAB1:GTP	yes	reactome/R-HSA-6814831.md	TBC1D20 binds RAB1:GTP	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	54	R-HSA-6814833	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP	yes	reactome/R-HSA-6814833.md	TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum-Golgi intermediate compartment membrane, from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	55	R-HSA-8870466	RGGT:CHM binds RABs	yes	reactome/R-HSA-8870466.md	RGGT:CHM binds RABs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol, the GDI-bound soluble pool of a prenylated Rab.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	66	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	67	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	68	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	69	R-HSA-6811411	GBF1 recruits ARF:GDP to the Golgi	yes	reactome/R-HSA-6811411.md	GBF1 recruits ARF:GDP to the Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	70	R-HSA-6811412	Active ARF recruits coatomer to the Golgi	yes	reactome/R-HSA-6811412.md	Active ARF recruits coatomer to the Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	71	R-HSA-6811414	GBF1 stimulates nucleotide exchange on ARF	yes	reactome/R-HSA-6811414.md	GBF1 stimulates nucleotide exchange on ARF	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	72	R-HSA-6811415	RAB:GTP recruits GBF1 to the Golgi membrane	yes	reactome/R-HSA-6811415.md	RAB:GTP recruits GBF1 to the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	73	R-HSA-6811417	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	yes	reactome/R-HSA-6811417.md	ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB1B	genes/human/RAB1B/RAB1B-ai-review.yaml	RAB1B	Q9H0U4	NCBITaxon:9606	Homo sapiens	74	R-HSA-6811418	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	yes	reactome/R-HSA-6811418.md	ARFGAPs stimulate ARF GTPase activity at the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Golgi membrane, asserted from nine Reactome reactions.
human	RAB24	genes/human/RAB24/RAB24-ai-review.yaml	RAB24	Q969Q5	NCBITaxon:9606	Homo sapiens	33	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	plasma membrane is Reactome degranulation context, not a specific RAB24 core location.
human	RAB24	genes/human/RAB24/RAB24-ai-review.yaml	RAB24	Q969Q5	NCBITaxon:9606	Homo sapiens	34	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	secretory granule membrane is Reactome degranulation context, not a specific RAB24 core location.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	65	R-HSA-9636564	SapM binds RAB7A	yes	reactome/R-HSA-9636564.md	SapM binds RAB7A	Homo sapiens	GO:0030670	phagocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RAB7A on phagosome membrane.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	75	R-HSA-8877451	MON1:CCZ1 exchanges GTP for GDP on RAB7	yes	reactome/R-HSA-8877451.md	MON1:CCZ1 exchanges GTP for GDP on RAB7	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for MON1:CCZ1 GEF exchanging nucleotide on RAB7 at lysosomal membrane.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	76	R-HSA-8877451	MON1:CCZ1 exchanges GTP for GDP on RAB7	yes	reactome/R-HSA-8877451.md	MON1:CCZ1 exchanges GTP for GDP on RAB7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic GDP-bound RAB7A.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	77	R-HSA-9636684	NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP	yes	reactome/R-HSA-9636684.md	NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway for bacterial effector NdkA affecting RAB7A.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	78	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for RAB7A in secretory granule exocytosis.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	79	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for RAB7A in neutrophil degranulation.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	93	R-HSA-2213248	Transport of antigen loaded MHC II molecules to surface	yes	reactome/R-HSA-2213248.md	Transport of antigen loaded MHC II molecules to surface	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome MHC class II antigen presentation pathway.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	94	R-HSA-8854255	TBC1D2A accelerates GTP hydrolysis by RAB7	yes	reactome/R-HSA-8854255.md	TBC1D2A accelerates GTP hydrolysis by RAB7	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TBC1D2A GAP pathway.
human	RAB7A	genes/human/RAB7A/RAB7A-ai-review.yaml	RAB7A	P51149	NCBITaxon:9606	Homo sapiens	95	R-HSA-8854329	TBC1D15 accelerates GTP hydrolysis by RAB7	yes	reactome/R-HSA-8854329.md	TBC1D15 accelerates GTP hydrolysis by RAB7	Homo sapiens	GO:0005765	lysosomal membrane	TAS	located_in	CC	false		ACCEPT	Reactome TBC1D15 GAP pathway.
human	RAB7B	genes/human/RAB7B/RAB7B-ai-review.yaml	RAB7B	Q96AH8	NCBITaxon:9606	Homo sapiens	22	R-HSA-8854329	TBC1D15 accelerates GTP hydrolysis by RAB7	yes	reactome/R-HSA-8854329.md	TBC1D15 accelerates GTP hydrolysis by RAB7	Homo sapiens	GO:0031902	late endosome membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway data places RAB7B at the late endosome membrane where TBC1D15 accelerates GTP hydrolysis.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	16	R-HSA-8876191	RAB9 GEFs exchange GTP for GDP on RAB9	yes	reactome/R-HSA-8876191.md	RAB9 GEFs exchange GTP for GDP on RAB9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for cytosol localization. Rab GTPases cycle between membrane-bound active state and cytosolic GDP-bound inactive state.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	17	R-HSA-8876191	RAB9 GEFs exchange GTP for GDP on RAB9	yes	reactome/R-HSA-8876191.md	RAB9 GEFs exchange GTP for GDP on RAB9	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for TGN membrane. RAB9A functions in transport to the TGN and localizes there via interaction with GCC185.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	18	R-HSA-6814670	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation	yes	reactome/R-HSA-6814670.md	ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for transport vesicle localization. RAB9A marks transport vesicles moving from late endosomes to TGN.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	19	R-HSA-6814674	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	yes	reactome/R-HSA-6814674.md	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation from different Reactome reaction.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	20	R-HSA-6814675	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN	yes	reactome/R-HSA-6814675.md	RAB9 binds RHOBTB3, bringing late endosome-derived vesicles to the TGN	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation from different Reactome reaction.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	21	R-HSA-6814671	Fusion of late-endosome derived vesicles at the TGN	yes	reactome/R-HSA-6814671.md	Fusion of late-endosome derived vesicles at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation for TGN membrane from different Reactome reaction.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	22	R-HSA-6814674	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	yes	reactome/R-HSA-6814674.md	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation for TGN membrane from different Reactome reaction.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	23	R-HSA-6814671	Fusion of late-endosome derived vesicles at the TGN	yes	reactome/R-HSA-6814671.md	Fusion of late-endosome derived vesicles at the TGN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation for cytosol from different Reactome reaction.
human	RAB9A	genes/human/RAB9A/RAB9A-ai-review.yaml	RAB9A	P51151	NCBITaxon:9606	Homo sapiens	24	R-HSA-9706390	RHOBTB3 binds interacting proteins at trans-Golgi network	yes	reactome/R-HSA-9706390.md	RHOBTB3 binds interacting proteins at trans-Golgi network	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate TAS annotation for cytosol from Reactome.
human	RAB9B	genes/human/RAB9B/RAB9B-ai-review.yaml	RAB9B	Q9NP90	NCBITaxon:9606	Homo sapiens	21	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome neutrophil degranulation pathway (R-HSA-6798743) suggesting plasma membrane localization.
human	RAB9B	genes/human/RAB9B/RAB9B-ai-review.yaml	RAB9B	Q9NP90	NCBITaxon:9606	Homo sapiens	22	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome suggesting RAB9B localization to secretory granule membrane during neutrophil degranulation.
human	RAB9B	genes/human/RAB9B/RAB9B-ai-review.yaml	RAB9B	Q9NP90	NCBITaxon:9606	Homo sapiens	23	R-HSA-9706390	RHOBTB3 binds interacting proteins at trans-Golgi network	yes	reactome/R-HSA-9706390.md	RHOBTB3 binds interacting proteins at trans-Golgi network	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation suggesting cytosolic localization from Reactome pathway R-HSA-9706390 (RHOBTB3 ATPase cycle).
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	20	R-HSA-8870461	RABGGTA and RABGGTB bind	yes	reactome/R-HSA-8870461.md	RABGGTA and RABGGTB bind	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct and specific localization for a soluble RabGGTase subunit (Reactome pathway reaction: RABGGTA and RABGGTB bind). This is the preferred, most specific location term.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	21	R-HSA-8870465	RGGT binds the RAB-binding subunit	yes	reactome/R-HSA-8870465.md	RGGT binds the RAB-binding subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct cytosolic localization (Reactome reaction: RGGT binds the RAB-binding subunit). Duplicate of the other cytosol TAS annotations from Reactome.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	22	R-HSA-8870466	RGGT:CHM binds RABs	yes	reactome/R-HSA-8870466.md	RGGT:CHM binds RABs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct cytosolic localization (Reactome reaction: RGGT:CHM binds RABs). Duplicate of the other cytosol TAS annotations from Reactome.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	23	R-HSA-8870469	RGGT geranylgeranylates RAB proteins	yes	reactome/R-HSA-8870469.md	RGGT geranylgeranylates RAB proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct cytosolic localization (Reactome reaction: RGGT geranylgeranylates RAB proteins). RabGGTase acts in the cytosol before the modified Rab associates with membranes.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	24	R-HSA-6801089	TP53 stimulates RABGGTA expression	yes	reactome/R-HSA-6801089.md	TP53 stimulates RABGGTA expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	RABGGTA is a soluble cytosolic enzyme, not a plasma-membrane protein. This TAS location derives from a Reactome regulatory reaction (TP53 stimulates RABGGTA expression) rather than a demonstrated plasma-membrane localization. Over-annotation of subcellular location.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	25	R-HSA-6801101	RABGGTA binds RABGGTB	yes	reactome/R-HSA-6801101.md	RABGGTA binds RABGGTB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	RABGGTA is cytosolic; this plasma-membrane location derives from a Reactome reaction (RABGGTA binds RABGGTB) and does not reflect a genuine plasma-membrane localization of the enzyme. Over-annotated.
human	RABGGTA	genes/human/RABGGTA/RABGGTA-ai-review.yaml	RABGGTA	Q92696	NCBITaxon:9606	Homo sapiens	26	R-HSA-6801109	CHM binds RGGT	yes	reactome/R-HSA-6801109.md	CHM binds RGGT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	RABGGTA is cytosolic; this plasma-membrane location derives from a Reactome reaction (CHM binds RGGT). The enzyme delivers the lipid anchor that lets Rab GTPases reach membranes, but the enzyme itself is not a plasma-membrane resident. Over-annotated.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	19	R-HSA-8870457	FarC-PTP4A2 binds RABGGTB	yes	reactome/R-HSA-8870457.md	FarC-PTP4A2 binds RABGGTB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol. RabGGTase is a soluble cytosolic enzyme, so this is the correct core cellular location.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	20	R-HSA-8870461	RABGGTA and RABGGTB bind	yes	reactome/R-HSA-8870461.md	RABGGTA and RABGGTB bind	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol (duplicate supporting-reaction source). Correct core cellular location.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	21	R-HSA-8870465	RGGT binds the RAB-binding subunit	yes	reactome/R-HSA-8870465.md	RGGT binds the RAB-binding subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol (duplicate supporting-reaction source). Correct core cellular location.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	22	R-HSA-8870466	RGGT:CHM binds RABs	yes	reactome/R-HSA-8870466.md	RGGT:CHM binds RABs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol (duplicate supporting-reaction source). Correct core cellular location.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	23	R-HSA-8870469	RGGT geranylgeranylates RAB proteins	yes	reactome/R-HSA-8870469.md	RGGT geranylgeranylates RAB proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to cytosol (the RabGGTase-catalyzed reaction). Correct core cellular location.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	24	R-HSA-6801101	RABGGTA binds RABGGTB	yes	reactome/R-HSA-6801101.md	RABGGTA binds RABGGTB	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS plasma-membrane annotation. RabGGTase is a cytosolic enzyme; the plasma-membrane association reflects the site where prenylated substrates (and GGTase-III substrate FBXL2) act rather than a stable localization of the enzyme itself.
human	RABGGTB	genes/human/RABGGTB/RABGGTB-ai-review.yaml	RABGGTB	P53611	NCBITaxon:9606	Homo sapiens	25	R-HSA-6801109	CHM binds RGGT	yes	reactome/R-HSA-6801109.md	CHM binds RGGT	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS plasma-membrane annotation (duplicate source). As above, reflects product/context localization rather than the soluble enzyme's core location.
human	RACK1	genes/human/RACK1/RACK1-ai-review.yaml	RACK1	P63244	NCBITaxon:9606	Homo sapiens	58	R-HSA-5626962	RACK1 localized in cytosol (Reactome).	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization.
human	RACK1	genes/human/RACK1/RACK1-ai-review.yaml	RACK1	P63244	NCBITaxon:9606	Homo sapiens	59	R-HSA-5626981	RACK1 localized in cytosol (Reactome).	yes	reactome/R-HSA-5626981.md	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization.
human	RACK1	genes/human/RACK1/RACK1-ai-review.yaml	RACK1	P63244	NCBITaxon:9606	Homo sapiens	60	R-HSA-5626982	RACK1 localized in cytosol (Reactome).	yes	reactome/R-HSA-5626982.md	TNF-α:TNFR1:NSMAF binds RACK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization.
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	50	R-HSA-5652005	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	yes	reactome/R-HSA-5652005.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RAD18:UBE2B complex binding to PCNA associated with damaged DNA.
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	51	R-HSA-5652009	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	yes	reactome/R-HSA-5652009.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RAD18:UBE2B monoubiquitinating PCNA.
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	52	R-HSA-8943003	SHPRH polyubiquitinates monoubiquitinated PCNA	yes	reactome/R-HSA-8943003.md	SHPRH polyubiquitinates monoubiquitinated PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SHPRH polyubiquitinating monoubiquitinated PCNA (RAD18 participates).
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	53	R-HSA-8943007	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N	yes	reactome/R-HSA-8943007.md	SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SHPRH binding monoUb-PCNA with RAD6:RAD18.
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	54	R-HSA-8943040	HLTF polyubiquitinates monoubiquitinated PCNA	yes	reactome/R-HSA-8943040.md	HLTF polyubiquitinates monoubiquitinated PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HLTF polyubiquitinating monoubiquitinated PCNA.
human	RAD18	genes/human/RAD18/RAD18-ai-review.yaml	RAD18	Q9NS91	NCBITaxon:9606	Homo sapiens	55	R-HSA-8943041	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N	yes	reactome/R-HSA-8943041.md	HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome annotation for HLTF binding monoUb-PCNA with RAD6:RAD18.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	2	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of PLK1 phosphorylation of centromeric cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	3	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of PP2A-B56 dephosphorylation of centromeric cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	4	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of separase cleavage of centromeric cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	5	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of separation of sister chromatids after RAD21 cleavage.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	6	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of CDK1 phosphorylation of sororin on centromeric cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	7	R-HSA-2473151	CDCA5 (Sororin) enables cohesion of sister centromeres	yes	reactome/R-HSA-2473151.md	CDCA5 (Sororin) enables cohesion of sister centromeres	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of sororin-enabled cohesion of sister centromeres.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	8	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0000775	chromosome, centromeric region	TAS	located_in	CC	false		ACCEPT	RAD21 remains at centromeres of metaphase chromosomes after most arm cohesin has been released by the prophase pathway, located at the inner pairing domain between sister chromatids; this centromeric pool is what separase cleaves at anaphase onset. This Reactome row places RAD21-containing cohesin at the centromere in the context of kinetochore assembly on centromeres carrying cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	88	R-HSA-2468039	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2	yes	reactome/R-HSA-2468039.md	Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns ESCO1/2 acetylation of SMC3 in arm cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	89	R-HSA-2468040	Cohesin binds PDS5 and WAPAL	yes	reactome/R-HSA-2468040.md	Cohesin binds PDS5 and WAPAL	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns cohesin binding PDS5 and WAPL.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	90	R-HSA-2468041	CDCA5 (Sororin) enables cohesion of sister chromosomal arms	yes	reactome/R-HSA-2468041.md	CDCA5 (Sororin) enables cohesion of sister chromosomal arms	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns sororin-enabled arm cohesion.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	91	R-HSA-2470935	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2	yes	reactome/R-HSA-2470935.md	Cohesin binding to decondensed chromatin is facilitated by NIPBL:MAU2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns NIPBL:MAU2-facilitated loading onto decondensed chromatin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	92	R-HSA-2473151	CDCA5 (Sororin) enables cohesion of sister centromeres	yes	reactome/R-HSA-2473151.md	CDCA5 (Sororin) enables cohesion of sister centromeres	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns sororin-enabled centromeric cohesion.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	93	R-HSA-2473152	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2	yes	reactome/R-HSA-2473152.md	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns ESCO1/2 acetylation of centromeric cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	94	R-HSA-3108212	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1	yes	reactome/R-HSA-3108212.md	SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns SMC5/6-NSMCE2 SUMOylation of RAD21 and STAG2.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	95	R-HSA-9011997	ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter	yes	reactome/R-HSA-9011997.md	ESR1:ESTG, JUND:FOSB and Cohesin Complex bind distal enhancer elements in MYC gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD21 is nucleoplasmic (HPA immunofluorescence), where soluble cohesin, cohesin bound to decondensed chromatin and cohesin released from chromosome arms reside. This Reactome row concerns cohesin binding the distal MYC enhancer with ESR1 and JUND:FOSB.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	99	R-HSA-2466068	Phosphorylation of cohesin by PLK1 at chromosomal arms	yes	reactome/R-HSA-2466068.md	Phosphorylation of cohesin by PLK1 at chromosomal arms	Homo sapiens	GO:0005694	chromosome	TAS	located_in	CC	false		ACCEPT	RAD21 associates with chromosomes: scattered along arms before prophase, retained along prometaphase chromosomes and at metaphase centromeres, and mapped genome-wide by ChIP in interphase. This Reactome row concerns PLK1 phosphorylation of arm cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	100	R-HSA-2467794	Resolution of sister chromatids	yes	reactome/R-HSA-2467794.md	Resolution of sister chromatids	Homo sapiens	GO:0005694	chromosome	TAS	located_in	CC	false		ACCEPT	RAD21 associates with chromosomes: scattered along arms before prophase, retained along prometaphase chromosomes and at metaphase centromeres, and mapped genome-wide by ChIP in interphase. This Reactome row concerns resolution of sister chromatid arms.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	101	R-HSA-2468041	CDCA5 (Sororin) enables cohesion of sister chromosomal arms	yes	reactome/R-HSA-2468041.md	CDCA5 (Sororin) enables cohesion of sister chromosomal arms	Homo sapiens	GO:0005694	chromosome	TAS	located_in	CC	false		ACCEPT	RAD21 associates with chromosomes: scattered along arms before prophase, retained along prometaphase chromosomes and at metaphase centromeres, and mapped genome-wide by ChIP in interphase. This Reactome row concerns sororin-enabled arm cohesion.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	102	R-HSA-2468293	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	yes	reactome/R-HSA-2468293.md	CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms	Homo sapiens	GO:0005694	chromosome	TAS	located_in	CC	false		ACCEPT	RAD21 associates with chromosomes: scattered along arms before prophase, retained along prometaphase chromosomes and at metaphase centromeres, and mapped genome-wide by ChIP in interphase. This Reactome row concerns CDK1 phosphorylation of sororin on arm cohesin.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	104	R-HSA-2467794	Resolution of sister chromatids	yes	reactome/R-HSA-2467794.md	Resolution of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic RAD21 corresponds to (i) cohesin released from chromosome arms in prophase, which resides in the mitotic cytoplasm after nuclear envelope breakdown, and (ii) the caspase-generated 64-kDa C-terminal fragment that translocates to the cytoplasm in apoptosis. Neither pool performs RAD21's chromatin functions. Reactome places released, cleaved or deacetylated cohesin in the mitotic cytosol.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	105	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic RAD21 corresponds to (i) cohesin released from chromosome arms in prophase, which resides in the mitotic cytoplasm after nuclear envelope breakdown, and (ii) the caspase-generated 64-kDa C-terminal fragment that translocates to the cytoplasm in apoptosis. Neither pool performs RAD21's chromatin functions. Reactome places released, cleaved or deacetylated cohesin in the mitotic cytosol.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	106	R-HSA-2545203	Deacetylation of cleaved cohesin	yes	reactome/R-HSA-2545203.md	Deacetylation of cleaved cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic RAD21 corresponds to (i) cohesin released from chromosome arms in prophase, which resides in the mitotic cytoplasm after nuclear envelope breakdown, and (ii) the caspase-generated 64-kDa C-terminal fragment that translocates to the cytoplasm in apoptosis. Neither pool performs RAD21's chromatin functions. Reactome places released, cleaved or deacetylated cohesin in the mitotic cytosol.
human	RAD21	genes/human/RAD21/RAD21-ai-review.yaml	RAD21	O60216	NCBITaxon:9606	Homo sapiens	107	R-HSA-2545253	Deacetylation of cohesin	yes	reactome/R-HSA-2545253.md	Deacetylation of cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic RAD21 corresponds to (i) cohesin released from chromosome arms in prophase, which resides in the mitotic cytoplasm after nuclear envelope breakdown, and (ii) the caspase-generated 64-kDa C-terminal fragment that translocates to the cytoplasm in apoptosis. Neither pool performs RAD21's chromatin functions. Reactome places released, cleaved or deacetylated cohesin in the mitotic cytosol.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	205	R-HSA-5685230	CHEK1 phosphorylates RAD51	yes	reactome/R-HSA-5685230.md	CHEK1 phosphorylates RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	206	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	207	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	208	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	209	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	210	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	211	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	212	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	213	R-HSA-5693561	RAD51 binds BRCA2 at resected DNA DSBs	yes	reactome/R-HSA-5693561.md	RAD51 binds BRCA2 at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	214	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	215	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	216	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	217	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	218	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	219	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	220	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	221	R-HSA-9709571	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	yes	reactome/R-HSA-9709571.md	BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	222	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	223	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	237	R-HSA-5686642	RAD52 promotes single strand annealing at resected DNA DSBs	yes	reactome/R-HSA-5686642.md	RAD52 promotes single strand annealing at resected DNA DSBs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	238	R-HSA-5686657	ERCC1:XPF cleaves flaps generated by SSA	yes	reactome/R-HSA-5686657.md	ERCC1:XPF cleaves flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	239	R-HSA-5686663	Completion of SSA	yes	reactome/R-HSA-5686663.md	Completion of SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	240	R-HSA-5693564	Association of RAD51 with RAD52:DNA double-strand break ends	yes	reactome/R-HSA-5693564.md	Association of RAD51 with RAD52:DNA double-strand break ends	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	241	R-HSA-9007582	RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6	yes	reactome/R-HSA-9007582.md	RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	242	R-HSA-9853878	FIGNL1 binds DMC1, RAD51	yes	reactome/R-HSA-9853878.md	FIGNL1 binds DMC1, RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	243	R-HSA-9980006	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	yes	reactome/R-HSA-9980006.md	ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51	genes/human/RAD51/RAD51-ai-review.yaml	RAD51	Q06609	NCBITaxon:9606	Homo sapiens	244	R-HSA-9980021	LIG1 binds SSA sites	yes	reactome/R-HSA-9980021.md	LIG1 binds SSA sites	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	RAD51 functions in the nucleoplasm.
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	49	R-HSA-5685318	BCDX2 complex formation	yes	reactome/R-HSA-5685318.md	BCDX2 complex formation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, BCDX2 complex formation).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	50	R-HSA-5685319	CX3 complex formation	yes	reactome/R-HSA-5685319.md	CX3 complex formation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, CX3 complex formation).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	51	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, BCDX2 stabilizes RAD51 filament).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	52	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, CX3 binds D-loop structures).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	53	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	54	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	55	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	56	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	57	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	58	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	59	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	60	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	61	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, D-loop formation by PALB2/BRCA2/RAD51).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	62	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	63	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	64	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	65	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	66	R-HSA-983218	RAD51B:RAD51C binds single-stranded DNA	yes	reactome/R-HSA-983218.md	RAD51B:RAD51C binds single-stranded DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, RAD51B:RAD51C binds ssDNA).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	67	R-HSA-983285	RAD51B binds RAD51C	yes	reactome/R-HSA-983285.md	RAD51B binds RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome, RAD51B binds RAD51C).
human	RAD51C	genes/human/RAD51C/RAD51C-ai-review.yaml	RAD51C	O43502	NCBITaxon:9606	Homo sapiens	68	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization (Reactome HR pathway step).
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	90	R-HSA-4341072	SUMOylation of RARA with SUMO2	yes	reactome/R-HSA-4341072.md	SUMOylation of RARA with SUMO2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	111	R-HSA-5334854	RAR:RXR binds SUMO-CRABP2:atRA	yes	reactome/R-HSA-5334854.md	RAR:RXR binds SUMO-CRABP2:atRA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	112	R-HSA-5634103	SUMO-CRABP2 dissociates from atRA:RAR:RXR	yes	reactome/R-HSA-5634103.md	SUMO-CRABP2 dissociates from atRA:RAR:RXR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	113	R-HSA-9009817	Acitretin binds to RAR:RXR	yes	reactome/R-HSA-9009817.md	Acitretin binds to RAR:RXR	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	114	R-HSA-376419	Formation of NR-MED1 Coactivator Complex	yes	reactome/R-HSA-376419.md	Formation of NR-MED1 Coactivator Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	115	R-HSA-382096	Formation of NR-NCOR Corepressor Complex	yes	reactome/R-HSA-382096.md	Formation of NR-NCOR Corepressor Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	116	R-HSA-9617067	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene	yes	reactome/R-HSA-9617067.md	All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RARA	genes/human/RARA/RARA-ai-review.yaml	RARA	P10276	NCBITaxon:9606	Homo sapiens	117	R-HSA-9860125	Binding of ATRA to TGFBR3 gene promoter	yes	reactome/R-HSA-9860125.md	Binding of ATRA to TGFBR3 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported nuclear subcompartment localization, but nucleoplasm is less informative than nucleus/chromatin for the core function.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	27	R-HSA-2682334	Ephrin receptor signaling pathway	yes	reactome/R-HSA-2682334.md	EPH-Ephrin signaling	Homo sapiens	GO:0048013	ephrin receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	RASA1 is recruited to phosphorylated EphB4 receptor and mediates downstream signaling effects. EphB4-RASA1 interaction is important for vascular development, and mutations affecting this interaction cause CM-AVM syndrome (PMID:30578106).
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	33	R-HSA-8981353	RASA1 stimulates RAS GTPase activity	yes	reactome/R-HSA-8981353.md	RASA1 stimulates RAS GTPase activity	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		REMOVE	Reactome annotation indicating RASA1 involvement in GTPase reactions. However, RASA1 itself does not have intrinsic GTPase activity - it stimulates the GTPase activity of Ras proteins.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	40	R-HSA-186798	GAP binding to PDGF-beta receptors	yes	reactome/R-HSA-186798.md	GAP binds to PDGF-beta receptors only	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for GAP binding to PDGF-beta receptors, indicating cytosolic localization consistent with RASA1 biology.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	41	R-HSA-4093331	Ras:GTP binding to p120-RasGAP	yes	reactome/R-HSA-4093331.md	Ras:GTP binds p120-RasGAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Ras:GTP binding to p120-RasGAP, indicating cytosolic localization.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	42	R-HSA-4093339	p120-RasGAP activating GTP hydrolysis on RAS	yes	reactome/R-HSA-4093339.md	p120-RasGAP activates GTP hydrolysis on RAS, inactivating it	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for p120-RasGAP activating GTP hydrolysis on RAS.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	43	R-HSA-5218845	Sphingosine kinase pathway	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation from sphingosine kinase pathway, indicating cytosol localization.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	44	R-HSA-5658231	RAS GAPs stimulating RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RAS GAPs stimulating RAS GTPase activity.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	45	R-HSA-5658435	RAS GAPs binding RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RAS GAPs binding RAS:GTP.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	46	R-HSA-8849094	ARHGAP35 binding RASA1	yes	reactome/R-HSA-8849094.md	ARHGAP35 binds RASA1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ARHGAP35 binding RASA1.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	47	R-HSA-8981353	RASA1 stimulates RAS GTPase activity	yes	reactome/R-HSA-8981353.md	RASA1 stimulates RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RASA1 stimulating RAS GTPase activity.
human	RASA1	genes/human/RASA1/RASA1-ai-review.yaml	RASA1	P20936	NCBITaxon:9606	Homo sapiens	48	R-HSA-8981355	RASA1 binding RAS:GTP	yes	reactome/R-HSA-8981355.md	RASA1 binds RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for RASA1 binding RAS:GTP.
human	RASA2	genes/human/RASA2/RASA2-ai-review.yaml	RASA2	Q15283	NCBITaxon:9606	Homo sapiens	12	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RASA2 is localized in the cytosol and is recruited to membranes to stimulate RAS GTPase activity. Reactome pathway includes RASA2 as a cytosolic GAP.
human	RASA2	genes/human/RASA2/RASA2-ai-review.yaml	RASA2	Q15283	NCBITaxon:9606	Homo sapiens	13	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway describing RAS GAP binding to RAS-GTP.
human	RASA3	genes/human/RASA3/RASA3-ai-review.yaml	RASA3	Q14644	NCBITaxon:9606	Homo sapiens	12	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RASA3 is primarily a cytosolic protein that translocates to the plasma membrane upon appropriate signals. Reactome pathway annotation.
human	RASA3	genes/human/RASA3/RASA3-ai-review.yaml	RASA3	Q14644	NCBITaxon:9606	Homo sapiens	13	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from different Reactome pathway.
human	RASA4	genes/human/RASA4/RASA4-ai-review.yaml	RASA4	O43374	NCBITaxon:9606	Homo sapiens	13	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation places RASA4 in the cytosol as part of the RAS GAP regulatory pathway, consistent with its resting localization.
human	RASA4	genes/human/RASA4/RASA4-ai-review.yaml	RASA4	O43374	NCBITaxon:9606	Homo sapiens	14	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RAS GAP binding to RAS:GTP places RASA4 in the cytosol prior to membrane translocation.
human	RASAL1	genes/human/RASAL1/RASAL1-ai-review.yaml	RASAL1	O95294	NCBITaxon:9606	Homo sapiens	12	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RAS GAPs stimulating RAS GTPase activity. RASAL1 is depicted as a cytosolic protein that can associate with the membrane.
human	RASAL1	genes/human/RASAL1/RASAL1-ai-review.yaml	RASAL1	O95294	NCBITaxon:9606	Homo sapiens	13	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for RAS GAPs binding RAS:GTP. RASAL1 is cytosolic and translocates to interact with membrane-anchored Ras.
human	RASAL2	genes/human/RASAL2/RASAL2-ai-review.yaml	RASAL2	Q9UJF2	NCBITaxon:9606	Homo sapiens	19	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This annotation indicates cytosolic localization based on Reactome pathway annotation. RASAL2 is predominantly cytoplasmic with enrichment at the plasma membrane upon calcium-dependent membrane recruitment through its C2 domains [file:human/RASAL2/RASAL2-deep-research-perplexity.md]. The cytosol annotation is accurate for the basal state of the protein.
human	RASAL2	genes/human/RASAL2/RASAL2-ai-review.yaml	RASAL2	Q9UJF2	NCBITaxon:9606	Homo sapiens	20	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	This is a duplicate cytosol annotation from a different Reactome pathway reference (RAS GAPs bind RAS:GTP). The annotation is accurate and consistent with RASAL2's documented cytoplasmic localization.
human	RASAL3	genes/human/RASAL3/RASAL3-ai-review.yaml	RASAL3	Q86YV0	NCBITaxon:9606	Homo sapiens	13	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from Reactome pathway annotation for RAS GAPs stimulating RAS GTPase activity.
human	RASAL3	genes/human/RASAL3/RASAL3-ai-review.yaml	RASAL3	Q86YV0	NCBITaxon:9606	Homo sapiens	14	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from Reactome pathway annotation for RAS GAPs binding RAS:GTP.
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	125	R-HSA-188386	Association of Rb with Cyclin E:Cdk2 complexes	yes	reactome/R-HSA-188386.md	Association of Rb with Cyclin E:Cdk2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	126	R-HSA-188390	Cyclin E:CDK2-mediated phosphorylation of RB1	yes	reactome/R-HSA-188390.md	Cyclin E:CDK2-mediated phosphorylation of RB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	127	R-HSA-69227	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-69227.md	Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	132	R-HSA-9659782	Defective RB1 does not bind E2F1,(E2F2,E2F3)	yes	reactome/R-HSA-9659782.md	Defective RB1 does not bind E2F1,(E2F2,E2F3)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	133	R-HSA-113503	PP2A mediated localization of RB1 protein in chromatin	yes	reactome/R-HSA-113503.md	PP2A mediated localization of RB1 protein in chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	134	R-HSA-187948	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2	yes	reactome/R-HSA-187948.md	Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	135	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	136	R-HSA-9851127	NPM1-ALK-dependent repression of pRB phosphorylation	yes	reactome/R-HSA-9851127.md	NPM1-ALK-dependent repression of pRB phosphorylation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	139	R-HSA-9660615	Defective RB1 does not translocate to the nucleus	yes	reactome/R-HSA-9660615.md	Defective RB1 does not translocate to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosolic localization sourced from a Reactome disease event ('Defective RB1 does not translocate to the nucleus') describing loss-of-function RB1 nonsense/frameshift/NLS-deletion mutants (e.g. RB1 R830_G887 / delEx24-25) that lack the bipartite C-terminal NLS (residues 860-876) and are retained in the cytosol (PMID:8413247 Zacksenhaus et al. 1993; PMID:9326330 Bremner et al. 1997). Wild-type RB1 is a nuclear chromatin-bound corepressor; cytosolic retention is restricted to NLS-loss tumor mutants and is therefore a pathological mislocalization rather than a constitutive cellular compartment for the wild-type protein.
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	140	R-HSA-9659820	RB1 translocates to the nucleus	yes	reactome/R-HSA-9659820.md	RB1 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosolic localization sourced from the Reactome event 'RB1 translocates to the nucleus', which describes the bipartite C-terminal NLS-dependent (residues 860-876) translocation of RB1 from the cytosol to the nucleus (PMID:8413247 Zacksenhaus et al. 1993). In the absence of the NLS only a small portion of RB1 reaches the nucleus while a large portion is retained in the cytosol. Cytosolic localization is therefore a transient pre-import state and an NLS-loss-mutant pathological state, not the steady-state compartment for the active wild-type protein.
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	141	R-HSA-9682712	nsp15 binds RB1	yes	reactome/R-HSA-9682712.md	nsp15 binds RB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for cytosolic localization sourced from the Reactome event 'nsp15 binds RB1', which describes SARS-CoV-1 non-structural protein 15 (nsp15) binding RB1 via its LXCXE/D motif and retaining RB1 in the cytosol (PMID:22301140 Bhardwaj et al. 2012). This is a viral-hijack mislocalization context — wild-type RB1 in uninfected cells is a chromatin-bound nuclear corepressor; cytosolic retention here is driven by viral nsp15 sequestration rather than reflecting a constitutive RB1 compartment.
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	161	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	162	R-HSA-2172666	RB1 binds condensin II	yes	reactome/R-HSA-2172666.md	RB1 binds condensin II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	163	R-HSA-9018017	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes	yes	reactome/R-HSA-9018017.md	RB1 binds and inhibits E2F1/2/3:DP1/2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	164	R-HSA-9659820	RB1 translocates to the nucleus	yes	reactome/R-HSA-9659820.md	RB1 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	165	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	166	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	167	R-HSA-9768288	RB1 and TFAP2A bind CDH1 gene promoter	yes	reactome/R-HSA-9768288.md	RB1 and TFAP2A bind CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	168	R-NUL-8985474	Runx2 binds RB1	yes	reactome/R-NUL-8985474.md	Runx2 binds RB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RB1	genes/human/RB1/RB1-ai-review.yaml	RB1	P06400	NCBITaxon:9606	Homo sapiens	169	R-NUL-8985490	Runx2:RB1 binds the BGLAP gene promoter	yes	reactome/R-NUL-8985490.md	Runx2:RB1 binds the BGLAP gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation for nucleoplasmic localization sourced from a Reactome pathway event. RB1 is a chromatin-bound nuclear corepressor that occupies E2F-target gene promoters in the nucleoplasm; nucleoplasmic localization of hypophosphorylated active RB1 is well established and is the compartment in which RB1 binds E2F1/2/3 and recruits chromatin corepressors (HDAC1, SUV39H1, BRG1/SMARCA4) (PMID:7923370; deep research synthesis).
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	4	R-HSA-5673001	RAF/MAP kinase cascade	yes	reactome/R-HSA-5673001.md	RAF/MAP kinase cascade	Homo sapiens	GO:0000165	MAPK cascade	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome places RBX1-containing ligases in the RAF/MAP kinase cascade pathway.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	9	R-HSA-69598	Ubiquitination of phosphorylated CDC25A	yes	reactome/R-HSA-69598.md	Ubiquitination of phosphorylated CDC25A	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	RBX1 supplies the RING activity that transfers ubiquitin from a charged E2 onto CRL-recruited substrates; the annotation is the parent of the more precise ubiquitin protein ligase activity (GO:0061630) also annotated here.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	73	R-HSA-1234169	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234169.md	Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	74	R-HSA-1234172	Nuclear VBC complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-1234172.md	Nuclear VBC complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	75	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	76	R-HSA-2220967	p-NICD1 PEST domain mutants do not bind FBXW7	yes	reactome/R-HSA-2220967.md	p-NICD1 PEST domain mutants do not bind FBXW7	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	77	R-HSA-2220978	FBXW7 WD mutants do not bind NICD1	yes	reactome/R-HSA-2220978.md	FBXW7 WD mutants do not bind NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	78	R-HSA-5635854	GLI2,3 are degraded by the proteasome	yes	reactome/R-HSA-5635854.md	GLI2,3 are degraded by the proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	79	R-HSA-5635855	phosphorylated GLI proteins bind SPOP:CUL3:RBX1	yes	reactome/R-HSA-5635855.md	phosphorylated GLI proteins bind SPOP:CUL3:RBX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	80	R-HSA-5635856	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	yes	reactome/R-HSA-5635856.md	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	81	R-HSA-5652005	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	yes	reactome/R-HSA-5652005.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	82	R-HSA-5652009	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	yes	reactome/R-HSA-5652009.md	RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	83	R-HSA-5689317	Formation of the pre-incision complex in GG-NER	yes	reactome/R-HSA-5689317.md	Formation of the pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	84	R-HSA-5689861	Recruitment of XPA and release of CAK	yes	reactome/R-HSA-5689861.md	Recruitment of XPA and release of CAK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	85	R-HSA-5690213	DNA polymerases delta, epsilon or kappa bind the GG-NER site	yes	reactome/R-HSA-5690213.md	DNA polymerases delta, epsilon or kappa bind the GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	86	R-HSA-5690988	3'-incision of DNA by ERCC5 (XPG) in GG-NER	yes	reactome/R-HSA-5690988.md	3'-incision of DNA by ERCC5 (XPG) in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	87	R-HSA-5690990	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	yes	reactome/R-HSA-5690990.md	5'- incision of DNA by ERCC1:ERCC4 in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	88	R-HSA-5690991	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	yes	reactome/R-HSA-5690991.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	89	R-HSA-5690996	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	yes	reactome/R-HSA-5690996.md	ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	90	R-HSA-5691000	TFIIH binds GG-NER site to form a verification complex	yes	reactome/R-HSA-5691000.md	TFIIH binds GG-NER site to form a verification complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	91	R-HSA-5691006	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	yes	reactome/R-HSA-5691006.md	XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	92	R-HSA-5696655	PARP1 or PARP2 PARylates DDB2 and autoPARylates	yes	reactome/R-HSA-5696655.md	PARP1 or PARP2 PARylates DDB2 and autoPARylates	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	93	R-HSA-5696664	PARP1 or PARP2 binds DDB2 at GG-NER site	yes	reactome/R-HSA-5696664.md	PARP1 or PARP2 binds DDB2 at GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	94	R-HSA-5696670	CHD1L is recruited to GG-NER site	yes	reactome/R-HSA-5696670.md	CHD1L is recruited to GG-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	95	R-HSA-6781833	ERCC8 (CSA) binds stalled RNA Pol II	yes	reactome/R-HSA-6781833.md	ERCC8 (CSA) binds stalled RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	96	R-HSA-6781867	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	yes	reactome/R-HSA-6781867.md	ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	97	R-HSA-6782004	Assembly of the pre-incision complex in TC-NER	yes	reactome/R-HSA-6782004.md	Assembly of the pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	98	R-HSA-6782069	UVSSA:USP7 deubiquitinates ERCC6	yes	reactome/R-HSA-6782069.md	UVSSA:USP7 deubiquitinates ERCC6	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	99	R-HSA-6782131	ERCC2-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-6782131.md	ERCC2-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	100	R-HSA-6782138	ERCC5 and RPA bind TC-NER site	yes	reactome/R-HSA-6782138.md	ERCC5 and RPA bind TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	101	R-HSA-6782141	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	yes	reactome/R-HSA-6782141.md	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	102	R-HSA-6782204	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	yes	reactome/R-HSA-6782204.md	5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	103	R-HSA-6782208	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	yes	reactome/R-HSA-6782208.md	Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	104	R-HSA-6782211	DNA polymerases delta, epsilon or kappa bind the TC-NER site	yes	reactome/R-HSA-6782211.md	DNA polymerases delta, epsilon or kappa bind the TC-NER site	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	105	R-HSA-6782224	3' incision by ERCC5 (XPG) in TC-NER	yes	reactome/R-HSA-6782224.md	3' incision by ERCC5 (XPG) in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	106	R-HSA-6782227	Ligation of newly synthesized repair patch to incised DNA in TC-NER	yes	reactome/R-HSA-6782227.md	Ligation of newly synthesized repair patch to incised DNA in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	107	R-HSA-6782234	Recovery of RNA synthesis after TC-NER	yes	reactome/R-HSA-6782234.md	Recovery of RNA synthesis after TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	108	R-HSA-6782943	UV-DDB ubiquitinates XPC	yes	reactome/R-HSA-6782943.md	UV-DDB ubiquitinates XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	109	R-HSA-6790454	SUMOylation of XPC	yes	reactome/R-HSA-6790454.md	SUMOylation of XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	110	R-HSA-6790487	RNF111 ubiquitinates SUMOylated XPC	yes	reactome/R-HSA-6790487.md	RNF111 ubiquitinates SUMOylated XPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	111	R-HSA-68946	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	yes	reactome/R-HSA-68946.md	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	112	R-HSA-69598	Ubiquitination of phosphorylated CDC25A	yes	reactome/R-HSA-69598.md	Ubiquitination of phosphorylated CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	113	R-HSA-8939688	SCF(SKP2) complex binds RUNX2	yes	reactome/R-HSA-8939688.md	SCF(SKP2) complex binds RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	114	R-HSA-8939706	SCF(SKP2) polyubiquitinates RUNX2	yes	reactome/R-HSA-8939706.md	SCF(SKP2) polyubiquitinates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	115	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	116	R-HSA-8952639	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952639.md	NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	117	R-HSA-8955245	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	yes	reactome/R-HSA-8955245.md	CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	118	R-HSA-8955285	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8955285.md	COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	119	R-HSA-8956045	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956045.md	COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	120	R-HSA-9684118	ERCC3-facilitated RNA Pol II backtracking in TC-NER	yes	reactome/R-HSA-9684118.md	ERCC3-facilitated RNA Pol II backtracking in TC-NER	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	121	R-HSA-9708517	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	yes	reactome/R-HSA-9708517.md	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	122	R-HSA-9708525	BACH1:FBXL17 binds SCF(SKP2) complex	yes	reactome/R-HSA-9708525.md	BACH1:FBXL17 binds SCF(SKP2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	123	R-HSA-9725023	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	yes	reactome/R-HSA-9725023.md	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	124	R-HSA-9725030	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	yes	reactome/R-HSA-9725030.md	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	125	R-HSA-9762091	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	yes	reactome/R-HSA-9762091.md	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	126	R-HSA-9762093	BTRC binds p-S344, 347 NFE2L2	yes	reactome/R-HSA-9762093.md	BTRC binds p-S344, 347 NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	127	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	128	R-NUL-2064853	FBXW7 binds phosphorylated NICD1	yes	reactome/R-NUL-2064853.md	FBXW7 binds phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	129	R-NUL-2064883	FBXW7 mediates ubiquitination of phosphorylated NICD1	yes	reactome/R-NUL-2064883.md	FBXW7 mediates ubiquitination of phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	130	R-NUL-9604628	FBXW7 promotes ubiquitination of mouse p-NICD4	yes	reactome/R-NUL-9604628.md	FBXW7 promotes ubiquitination of mouse p-NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localisation of RBX1-containing ligases, as assigned to the individual Reactome reactions in which the RBX1-cullin catalytic module ubiquitinates nuclear substrates, and as seen by immunofluorescence.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	140	R-HSA-1170539	Prolactin receptor is internalized	yes	reactome/R-HSA-1170539.md	Prolactin receptor is internalized	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	141	R-HSA-1234159	Proteasome proteolyzes ub-HIF-alpha	yes	reactome/R-HSA-1234159.md	Proteasome proteolyzes ub-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	142	R-HSA-1234163	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234163.md	Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	143	R-HSA-1234173	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	yes	reactome/R-HSA-1234173.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF3A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	144	R-HSA-1234175	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	yes	reactome/R-HSA-1234175.md	ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	145	R-HSA-1234177	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	yes	reactome/R-HSA-1234177.md	Cytosolic PHD2,3 hydroxylates proline residues on HIF1A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	146	R-HSA-1234183	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-1234183.md	Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	147	R-HSA-1370500	PRLR binds SCF beta-TrCP complex	yes	reactome/R-HSA-1370500.md	PRLR binds SCF beta-TrCP complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	148	R-HSA-1504190	DVL is ubiquitinated by CUL3:KLHL12:RBX1	yes	reactome/R-HSA-1504190.md	DVL is ubiquitinated by CUL3:KLHL12:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	149	R-HSA-1504193	Ubiquitinated DVL is degraded by the proteasome	yes	reactome/R-HSA-1504193.md	Ubiquitinated DVL is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	150	R-HSA-1504213	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex	yes	reactome/R-HSA-1504213.md	DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	151	R-HSA-180540	Multi-ubiquitination of APOBEC3G	yes	reactome/R-HSA-180540.md	Multi-ubiquitination of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	152	R-HSA-180555	Association of APOBEC3G:Vif with the Cul5-SCF complex	yes	reactome/R-HSA-180555.md	Association of APOBEC3G:Vif with the Cul5-SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	153	R-HSA-180603	Proteosome-mediated degradation of APOBEC3G	yes	reactome/R-HSA-180603.md	Proteosome-mediated degradation of APOBEC3G	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	154	R-HSA-209063	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	yes	reactome/R-HSA-209063.md	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	155	R-HSA-209125	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	yes	reactome/R-HSA-209125.md	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	156	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	157	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	158	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	159	R-HSA-5610742	SCF(beta-TrCP) ubiquitinates p-GLI1	yes	reactome/R-HSA-5610742.md	SCF(beta-TrCP) ubiquitinates p-GLI1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	160	R-HSA-5610746	SCF(beta-TrCP) ubiquitinates p-GLI3	yes	reactome/R-HSA-5610746.md	SCF(beta-TrCP) ubiquitinates p-GLI3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	161	R-HSA-5658424	KBTBD7:CUL3:RBX1 ubiquitinates NF1	yes	reactome/R-HSA-5658424.md	KBTBD7:CUL3:RBX1 ubiquitinates NF1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	162	R-HSA-8853496	SCF:FBXL7 binds AURKA	yes	reactome/R-HSA-8853496.md	SCF:FBXL7 binds AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	163	R-HSA-8854041	SCF-FBXL7 ubiquitinates AURKA	yes	reactome/R-HSA-8854041.md	SCF-FBXL7 ubiquitinates AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	164	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	165	R-HSA-8854051	SCF-FBXL18 ubiquitinates FBXL7	yes	reactome/R-HSA-8854051.md	SCF-FBXL18 ubiquitinates FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	166	R-HSA-8854052	Formation of the SCF-FBXL7 complex	yes	reactome/R-HSA-8854052.md	Formation of the SCF-FBXL7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	167	R-HSA-8932327	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	yes	reactome/R-HSA-8932327.md	NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	168	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	169	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	170	R-HSA-8952625	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952625.md	NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	171	R-HSA-8952626	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952626.md	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	172	R-HSA-8952630	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952630.md	NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	173	R-HSA-8952631	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952631.md	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	174	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	175	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	176	R-HSA-8956025	AcM-UBE2M transfers NEDD8 to CUL9:RBX1	yes	reactome/R-HSA-8956025.md	AcM-UBE2M transfers NEDD8 to CUL9:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	177	R-HSA-8956026	CUL9:RBX1 ubiquitinates BIRC5	yes	reactome/R-HSA-8956026.md	CUL9:RBX1 ubiquitinates BIRC5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	178	R-HSA-8956031	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex	yes	reactome/R-HSA-8956031.md	NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	179	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	180	R-HSA-8956050	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1	yes	reactome/R-HSA-8956050.md	NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	181	R-HSA-8956099	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	yes	reactome/R-HSA-8956099.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	182	R-HSA-8956103	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	yes	reactome/R-HSA-8956103.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	183	R-HSA-8956106	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	yes	reactome/R-HSA-8956106.md	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	184	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	185	R-HSA-9712274	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	yes	reactome/R-HSA-9712274.md	NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	186	R-HSA-9755303	26S proteasome degrades HIFalpha	yes	reactome/R-HSA-9755303.md	26S proteasome degrades HIFalpha	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	187	R-HSA-9755505	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	yes	reactome/R-HSA-9755505.md	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	188	R-HSA-9755507	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	189	R-HSA-9758090	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	190	R-HSA-9759169	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	yes	reactome/R-HSA-9759169.md	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	191	R-HSA-9759172	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	yes	reactome/R-HSA-9759172.md	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	192	R-HSA-9766645	CUL3:RBX1 ubiquitinates KEAP1	yes	reactome/R-HSA-9766645.md	CUL3:RBX1 ubiquitinates KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	193	R-HSA-9766656	RBX1:CUL3 dissociates from forming autophagosome	yes	reactome/R-HSA-9766656.md	RBX1:CUL3 dissociates from forming autophagosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	194	R-HSA-9766677	MAP1LC3B binds KEAP1 and SQSTM1	yes	reactome/R-HSA-9766677.md	MAP1LC3B binds KEAP1 and SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	195	R-HSA-9766687	SESN1,SESN1 bind SQSTM1 and KEAP1	yes	reactome/R-HSA-9766687.md	SESN1,SESN1 bind SQSTM1 and KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	196	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	197	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	198	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	199	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	200	R-HSA-9833107	Association of NS1 (1C) with Cul5 and SCF	yes	reactome/R-HSA-9833107.md	Association of NS1 (1C) with Cul5 and SCF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	201	R-HSA-9833155	Ubiquitination of STAT2	yes	reactome/R-HSA-9833155.md	Ubiquitination of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	202	R-HSA-9929350	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	yes	reactome/R-HSA-9929350.md	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	203	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	204	R-HSA-9929353	Deubiquitination of CD274	yes	reactome/R-HSA-9929353.md	Deubiquitination of CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	205	R-HSA-9929357	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	yes	reactome/R-HSA-9929357.md	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	206	R-HSA-9929484	SPOP:CUL3:RBX1 binds to CD274	yes	reactome/R-HSA-9929484.md	SPOP:CUL3:RBX1 binds to CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	207	R-HSA-9929486	SPOP-mediated degradation of CD274 by 26S Proteosome	yes	reactome/R-HSA-9929486.md	SPOP-mediated degradation of CD274 by 26S Proteosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	208	R-HSA-9929490	CD274 ubiquitination by SPOP:CUL3:RBX1 complex	yes	reactome/R-HSA-9929490.md	CD274 ubiquitination by SPOP:CUL3:RBX1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	209	R-HSA-9954721	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	yes	reactome/R-HSA-9954721.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	210	R-HSA-9954723	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	yes	reactome/R-HSA-9954723.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic pool of the RBX1-cullin catalytic module, as assigned to Reactome reactions such as cytosolic VHL-EloBC-CUL2-RBX1 ubiquitination of hydroxyprolyl-HIF-alpha and SCF(beta-TrCP)-mediated degradation events.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	262	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0019788	NEDD8 transferase activity	TAS	enables	MF	false		ACCEPT	RBX1 is the RING E3 of the cullin neddylation reaction, binding UBE2M~NEDD8 and transferring NEDD8 to the conserved lysine of CUL1-CUL4.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	263	R-HSA-8952626	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952626.md	AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex	Homo sapiens	GO:0019788	NEDD8 transferase activity	TAS	enables	MF	false		ACCEPT	RBX1 is the RING E3 of the cullin neddylation reaction, binding UBE2M~NEDD8 and transferring NEDD8 to the conserved lysine of CUL1-CUL4.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	264	R-HSA-8952631	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952631.md	AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex	Homo sapiens	GO:0019788	NEDD8 transferase activity	TAS	enables	MF	false		ACCEPT	RBX1 is the RING E3 of the cullin neddylation reaction, binding UBE2M~NEDD8 and transferring NEDD8 to the conserved lysine of CUL1-CUL4.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	265	R-HSA-8952638	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952638.md	AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex	Homo sapiens	GO:0019788	NEDD8 transferase activity	TAS	enables	MF	false		ACCEPT	RBX1 is the RING E3 of the cullin neddylation reaction, binding UBE2M~NEDD8 and transferring NEDD8 to the conserved lysine of CUL1-CUL4.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	405	R-HSA-597592	Post-translational protein modification	yes	reactome/R-HSA-597592.md	Post-translational protein modification	Homo sapiens	GO:0043687	post-translational protein modification	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome's top-level 'post-translational protein modification' assignment for RBX1.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	453	R-HSA-1504190	DVL is ubiquitinated by CUL3:KLHL12:RBX1	yes	reactome/R-HSA-1504190.md	DVL is ubiquitinated by CUL3:KLHL12:RBX1	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	454	R-HSA-5635856	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	yes	reactome/R-HSA-5635856.md	SPOP:CUL3:RBX1 ubiquitinates GLI2,3	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	455	R-HSA-5658424	KBTBD7:CUL3:RBX1 ubiquitinates NF1	yes	reactome/R-HSA-5658424.md	KBTBD7:CUL3:RBX1 ubiquitinates NF1	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	456	R-HSA-9755505	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	yes	reactome/R-HSA-9755505.md	KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	457	R-HSA-9759172	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	yes	reactome/R-HSA-9759172.md	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	458	R-HSA-9762091	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	yes	reactome/R-HSA-9762091.md	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	459	R-HSA-9766645	CUL3:RBX1 ubiquitinates KEAP1	yes	reactome/R-HSA-9766645.md	CUL3:RBX1 ubiquitinates KEAP1	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core molecular function: RBX1 is the RING E3 of cullin-RING ligases, binding ubiquitin-charged E2s (CDC34/UBE2R, UBE2D) and positioning them for transfer onto substrates recruited by the cullin's receptor module.
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	462	R-HSA-9711123	Cellular response to chemical stress	yes	reactome/R-HSA-9711123.md	Cellular response to chemical stress	Homo sapiens	GO:0062197	cellular response to chemical stress	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome assigns RBX1-containing CRL3(KEAP1) activity to the cellular response to chemical stress (the NRF2 pathway).
human	RBX1	genes/human/RBX1/RBX1-ai-review.yaml	RBX1	P62877	NCBITaxon:9606	Homo sapiens	474	R-HSA-4641258	Degradation of DVL	yes	reactome/R-HSA-4641258.md	Degradation of DVL	Homo sapiens	GO:0090090	negative regulation of canonical Wnt signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	CUL3-KLHL12-RBX1 ubiquitinates DVL, and SCF(beta-TrCP) degrades phospho-beta-catenin, both negative inputs to canonical Wnt signalling.
human	RCE1	genes/human/RCE1/RCE1-ai-review.yaml	RCE1	Q9Y256	NCBITaxon:9606	Homo sapiens	9	R-HSA-5673001	RAF/MAP kinase cascade	yes	reactome/R-HSA-5673001.md	RAF/MAP kinase cascade	Homo sapiens	GO:0000165	MAPK cascade	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	MAPK-cascade involvement is indirect/downstream; RCE1 processes Ras upstream of the cascade but is not itself a cascade component.
human	RCE1	genes/human/RCE1/RCE1-ai-review.yaml	RCE1	Q9Y256	NCBITaxon:9606	Homo sapiens	10	R-HSA-9647999	RCE1 cleaves S-Farn proRAS proteins	yes	reactome/R-HSA-9647999.md	RCE1 cleaves S-Farn proRAS proteins	Homo sapiens	GO:0004197	cysteine-type endopeptidase activity	TAS	enables	MF	false		MODIFY	RCE1 is a glutamate-type protease, not a cysteine-type endopeptidase; wrong catalytic class.
human	RCE1	genes/human/RCE1/RCE1-ai-review.yaml	RCE1	Q9Y256	NCBITaxon:9606	Homo sapiens	14	R-HSA-9653514	USP17L2 deubiquitinates RCE1	yes	reactome/R-HSA-9653514.md	USP17L2 deubiquitinates RCE1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane location (Reactome), consistent with the core localization.
human	RCE1	genes/human/RCE1/RCE1-ai-review.yaml	RCE1	Q9Y256	NCBITaxon:9606	Homo sapiens	15	R-HSA-9647999	RCE1 cleaves S-Farn proRAS proteins	yes	reactome/R-HSA-9647999.md	RCE1 cleaves S-Farn proRAS proteins	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane location (Reactome RAS processing), consistent with the core localization.
human	RCE1	genes/human/RCE1/RCE1-ai-review.yaml	RCE1	Q9Y256	NCBITaxon:9606	Homo sapiens	16	R-HSA-5696600	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1	yes	reactome/R-HSA-5696600.md	USP17 deubiquitinates RCE1, CDC25A, DDX58, IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	RCE1 is a polytopic ER membrane protein; a cytosol location is an over-annotation.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	12	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Retinoid metabolic process, Reactome TAS (canonical retinoid cycle in rods). Correct and core: RDH11 acts in retinoid metabolism / the visual retinoid cycle. This general BP term is appropriate for a retinaldehyde reductase.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	13	R-HSA-975634	Retinoid metabolism and transport	yes	reactome/R-HSA-975634.md	Retinoid metabolism and transport	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Duplicate retinoid metabolic process annotation from a second Reactome pathway (Retinoid metabolism and transport). Same correct, core BP as above.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	14	R-HSA-5362721	RDH5,RDH11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-5362721.md	RDH5,RDH11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	TAS	enables	MF	false		MODIFY	NAD+-dependent all-trans-retinol dehydrogenase, Reactome TAS. RDH11 has a clear preference for NADP(H) (~800-fold lower Km for NADP+/NADPH than NAD+/NADH), so the NAD+-specific cofactor term misrepresents the physiological cofactor. The correct cofactor-specific term is the NADP+ form (GO:0052650).
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	15	R-HSA-5419165	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	yes	reactome/R-HSA-5419165.md	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	Core NADP-dependent all-trans-retinol dehydrogenase activity, Reactome TAS (RDH11 et al. reduce atRAL to atROL). Correct and well-supported; redundant with the EXP/IDA/IEA annotations to the same term.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	16	R-HSA-74872	RDH10,11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-74872.md	RDH10,11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	Core NADP-dependent all-trans-retinol dehydrogenase activity, Reactome TAS. Correct; redundant with the other annotations to this term.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	22	R-HSA-975629	RDH11 reduces RBP2:atRAL to RBP2:atROL	yes	reactome/R-HSA-975629.md	RDH11 reduces RBP2:atRAL to RBP2:atROL	Homo sapiens	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	High-level oxidoreductase grouping term (CH-OH donor, NAD/NADP acceptor), Reactome TAS. Chemically correct but far too general for a well-characterized retinol dehydrogenase; the specific NADP-dependent retinol dehydrogenase term is more informative.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	27	R-HSA-5362721	RDH5,RDH11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-5362721.md	RDH5,RDH11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane, Reactome TAS. Correct core component; redundant with the experimental annotations to the same term.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	28	R-HSA-5419165	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	yes	reactome/R-HSA-5419165.md	RDH11,14,DHRS3,DRHS4 reduce atRAL to atROL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane, Reactome TAS. Correct core component; redundant.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	29	R-HSA-74872	RDH10,11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-74872.md	RDH10,11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane, Reactome TAS. Correct core component; redundant.
human	RDH11	genes/human/RDH11/RDH11-ai-review.yaml	RDH11	Q8TC12	NCBITaxon:9606	Homo sapiens	30	R-HSA-975629	RDH11 reduces RBP2:atRAL to RBP2:atROL	yes	reactome/R-HSA-975629.md	RDH11 reduces RBP2:atRAL to RBP2:atROL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane, Reactome TAS. Correct core component; redundant.
human	RDH12	genes/human/RDH12/RDH12-ai-review.yaml	RDH12	Q96NR8	NCBITaxon:9606	Homo sapiens	14	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Correct. RDH12 acts in the retinoid (visual) cycle, reducing retinaldehyde to retinol. Accurate general process annotation from Reactome.
human	RDH12	genes/human/RDH12/RDH12-ai-review.yaml	RDH12	Q96NR8	NCBITaxon:9606	Homo sapiens	15	R-HSA-2464822	RDH12 reduces atRAL to atROL	yes	reactome/R-HSA-2464822.md	RDH12 reduces atRAL to atROL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	Core molecular function, consistent with the experimental annotations. Reactome models RDH12 reducing all-trans-retinal to all-trans-retinol.
human	RDH12	genes/human/RDH12/RDH12-ai-review.yaml	RDH12	Q96NR8	NCBITaxon:9606	Homo sapiens	16	R-HSA-2466861	Defective RDH12 does not reduce atRAL to atROL	yes	reactome/R-HSA-2466861.md	Defective RDH12 does not reduce atRAL to atROL	Homo sapiens	GO:0052650	all-trans-retinol dehydrogenase (NADP+) activity	TAS	enables	MF	false		ACCEPT	"Core molecular function from the Reactome ""defective RDH12"" (LCA13/RP53) reaction; the wild-type activity is the NADP(H)-dependent atRAL->atROL reduction."
human	RDH12	genes/human/RDH12/RDH12-ai-review.yaml	RDH12	Q96NR8	NCBITaxon:9606	Homo sapiens	21	R-HSA-2466861	Defective RDH12 does not reduce atRAL to atROL	yes	reactome/R-HSA-2466861.md	Defective RDH12 does not reduce atRAL to atROL	Homo sapiens	GO:0060342	photoreceptor inner segment membrane	TAS	located_in	CC	false		ACCEPT	Consistent with the ER-membrane / inner-segment localization of RDH12. Reactome places the reaction at the photoreceptor inner segment membrane.
human	RDH12	genes/human/RDH12/RDH12-ai-review.yaml	RDH12	Q96NR8	NCBITaxon:9606	Homo sapiens	26	R-HSA-2464822	RDH12 reduces atRAL to atROL	yes	reactome/R-HSA-2464822.md	RDH12 reduces atRAL to atROL	Homo sapiens	GO:0060342	photoreceptor inner segment membrane	TAS	located_in	CC	false		ACCEPT	Consistent with RDH12's ER-membrane / photoreceptor inner-segment localization. Duplicate of the other Reactome inner-segment-membrane annotation.
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	15	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome (canonical retinoid cycle in rods) traceable assignment of a retinoid metabolic role. Correct: RDH5 oxidizes 11-cis-retinol to 11-cis-retinal within the retinoid/visual cycle in the RPE.
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	17	R-HSA-2454081	RDH5 oxidises 11cROL to 11cRAL	yes	reactome/R-HSA-2454081.md	RDH5 oxidises 11cROL to 11cRAL	Homo sapiens	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	TAS	enables	MF	false		MODIFY	"Reactome maps RDH5 catalysis to the generic all-trans-retinol dehydrogenase GO term, but the Reactome reaction it annotates (""RDH5 oxidises 11cROL to 11cRAL"") is explicitly the 11-cis reaction, and UniProt shows RDH5 has no all-trans activity. Modify to the cis-specific term."
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	18	R-HSA-2466832	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	yes	reactome/R-HSA-2466832.md	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	Homo sapiens	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	TAS	enables	MF	false		MODIFY	"Reactome reaction (""Defective RDH5 does not oxidise 11cROL to 11cRAL"") again describes the 11-cis reaction but is mapped to the generic all-trans GO term. Same wrong-substrate issue; modify to the 11-cis-specific molecular function."
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	19	R-HSA-5362721	RDH5,RDH11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-5362721.md	RDH5,RDH11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0004745	all-trans-retinol dehydrogenase (NAD+) activity	TAS	enables	MF	false		MODIFY	"Reactome reaction (""RDH5,RDH11 oxidise 11cROL to 11cRAL"") is the 11-cis oxidation mapped to the generic all-trans GO term. Modify to the substrate-correct 11-cis term."
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	21	R-HSA-2454081	RDH5 oxidises 11cROL to 11cRAL	yes	reactome/R-HSA-2454081.md	RDH5 oxidises 11cROL to 11cRAL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization of the RDH5 reaction to the ER membrane. Correct and consistent with IDA (PMID:11675386) and UniProt. Core localization.
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	22	R-HSA-5362721	RDH5,RDH11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-5362721.md	RDH5,RDH11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization (RDH5,RDH11 reaction) to the ER membrane. Correct; redundant with other ER membrane annotations. Core localization.
human	RDH5	genes/human/RDH5/RDH5-ai-review.yaml	RDH5	Q92781	NCBITaxon:9606	Homo sapiens	31	R-HSA-2466832	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	yes	reactome/R-HSA-2466832.md	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization (defective-RDH5 reaction) to the ER membrane. Correct; redundant with other ER membrane annotations. Core localization.
human	RELN	genes/human/RELN/RELN-ai-review.yaml	RELN	P78509	NCBITaxon:9606	Homo sapiens	64	R-HSA-8854466	VLDLR binds RELN	yes	reactome/R-HSA-8854466.md	VLDLR binds RELN	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reelin is a secreted glycoprotein that functions in the extracellular matrix; the extracellular region localization is biologically appropriate.
human	RELN	genes/human/RELN/RELN-ai-review.yaml	RELN	P78509	NCBITaxon:9606	Homo sapiens	65	R-HSA-8855232	RELN:VLDLR binds DAB1	yes	reactome/R-HSA-8855232.md	RELN:VLDLR binds DAB1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reelin is a secreted glycoprotein that functions in the extracellular matrix; the extracellular region localization is biologically appropriate.
human	RELN	genes/human/RELN/RELN-ai-review.yaml	RELN	P78509	NCBITaxon:9606	Homo sapiens	66	R-HSA-8855237	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1	yes	reactome/R-HSA-8855237.md	FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reelin is a secreted glycoprotein that functions in the extracellular matrix; the extracellular region localization is biologically appropriate.
human	RELN	genes/human/RELN/RELN-ai-review.yaml	RELN	P78509	NCBITaxon:9606	Homo sapiens	67	R-HSA-8855259	RELN:VLDLR:DAB1 binds SH3KBP1	yes	reactome/R-HSA-8855259.md	RELN:VLDLR:DAB1 binds SH3KBP1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reelin is a secreted glycoprotein that functions in the extracellular matrix; the extracellular region localization is biologically appropriate.
human	RFK	genes/human/RFK/RFK-ai-review.yaml	RFK	Q969G6	NCBITaxon:9606	Homo sapiens	11	R-HSA-196843	Vitamin B2 (riboflavin) metabolism	yes	reactome/R-HSA-196843.md	Vitamin B2 (riboflavin) metabolism	Homo sapiens	GO:0006771	riboflavin metabolic process	TAS	involved_in	BP	false		ACCEPT	"Author/curator (TAS) annotation from the Reactome ""Vitamin B2 (riboflavin) metabolism"" pathway. Accurately places RFK in riboflavin metabolism. Accept as a core process."
human	RFK	genes/human/RFK/RFK-ai-review.yaml	RFK	Q969G6	NCBITaxon:9606	Homo sapiens	12	R-HSA-196964	RFK:Mg2+ phosphorylates RIB	yes	reactome/R-HSA-196964.md	RFK:Mg2+ phosphorylates RIB	Homo sapiens	GO:0008531	riboflavin kinase activity	TAS	enables	MF	false		ACCEPT	"Author/curator (TAS) annotation from the Reactome reaction ""RFK:Mg2+ phosphorylates RIB"", describing RFK phosphorylating riboflavin to FMN using zinc or magnesium. Correct core molecular function. Accept."
human	RFK	genes/human/RFK/RFK-ai-review.yaml	RFK	Q969G6	NCBITaxon:9606	Homo sapiens	19	R-HSA-196964	RFK:Mg2+ phosphorylates RIB	yes	reactome/R-HSA-196964.md	RFK:Mg2+ phosphorylates RIB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Author/curator (TAS) annotation from Reactome placing RFK in the cytosol; Reactome explicitly describes it as ""a cytosolic enzyme"". This is the preferred, specific core location, concordant with the UniProt cytoplasm call. Accept."
human	RFT1	genes/human/RFT1/RFT1-ai-review.yaml	RFT1	Q96AA3	NCBITaxon:9606	Homo sapiens	9	R-HSA-4570573	Defective RFT1 does not flip the N-glycan precursor	yes	reactome/R-HSA-4570573.md	Defective RFT1 does not flip the N-glycan precursor	Homo sapiens	GO:0034202	glycolipid floppase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"TAS from the Reactome disease reaction ""Defective RFT1 does not flip the N-glycan precursor"". Reactome asserts the canonical flippase model, which is a reasonable reading of the genetics but inherits the same ATP-dependence mismatch as the IDA row, and additionally states as settled a mechanism that the primary literature still treats as open."
human	RFT1	genes/human/RFT1/RFT1-ai-review.yaml	RFT1	Q96AA3	NCBITaxon:9606	Homo sapiens	14	R-HSA-4570573	Defective RFT1 does not flip the N-glycan precursor	yes	reactome/R-HSA-4570573.md	Defective RFT1 does not flip the N-glycan precursor	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS localization from the same Reactome disease reaction. Unlike the molecular function assertion in that reaction, the localization claim is uncontroversial.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	18	R-HSA-388396	GPCR downstream signalling	yes	reactome/R-HSA-388396.md	GPCR downstream signalling	Homo sapiens	GO:0007186	G protein-coupled receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation for GPCR downstream signaling. RGS20 participates in this pathway by regulating G protein activity.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	19	R-HSA-8982020	G alpha (i)-i1/i2/i3 in G (i):RGS complex is inactivated	yes	reactome/R-HSA-8982020.md	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		REMOVE	This Reactome annotation incorrectly assigns GTPase activity to RGS20. RGS20 does not hydrolyze GTP itself; it accelerates GTP hydrolysis by Galpha subunits.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	20	R-HSA-8982021	G alpha (z) in G alpha (z):RGS complex is inactivated	yes	reactome/R-HSA-8982021.md	G alpha (z) in G alpha (z):RGS complex is inactivated	Homo sapiens	GO:0003924	GTPase activity	TAS	enables	MF	false		REMOVE	Same issue as above - incorrect assignment of GTPase activity to RGS20.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	21	R-HSA-8981892	Active G alpha (z) binds RGS proteins	yes	reactome/R-HSA-8981892.md	Active G alpha (z) binds RGS proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation indicating plasma membrane localization, consistent with RGS20's role in modulating membrane-associated GPCR signaling.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	22	R-HSA-8982012	G alpha (i):RGS dissociates to inactive G alpha (i)-i1/i2/i3	yes	reactome/R-HSA-8982012.md	G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate plasma membrane annotation from Reactome pathway.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	23	R-HSA-8982018	G alpha (z):RGS complex dissociates to give inactive G alpha (z)	yes	reactome/R-HSA-8982018.md	G alpha (z):RGS complex dissociates to give inactive G alpha (z)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate plasma membrane annotation from Reactome pathway.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	24	R-HSA-8982019	Active G alpha (i)-i1/i2/i3 binds RGS proteins	yes	reactome/R-HSA-8982019.md	Active G alpha (i)–i1/i2/i3 binds RGS proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate plasma membrane annotation from Reactome pathway.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	25	R-HSA-8982020	G alpha (i)-i1/i2/i3 in G (i):RGS complex is inactivated	yes	reactome/R-HSA-8982020.md	G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate plasma membrane annotation from Reactome pathway.
human	RGS20	genes/human/RGS20/RGS20-ai-review.yaml	RGS20	O76081	NCBITaxon:9606	Homo sapiens	26	R-HSA-8982021	G alpha (z) in G alpha (z):RGS complex is inactivated	yes	reactome/R-HSA-8982021.md	G alpha (z) in G alpha (z):RGS complex is inactivated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate plasma membrane annotation from Reactome pathway.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	6	R-HSA-2454081	RDH5 oxidises 11cROL to 11cRAL	yes	reactome/R-HSA-2454081.md	RDH5 oxidises 11cROL to 11cRAL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location (RDH5 oxidises 11cROL to 11cRAL). Consistent with the IDA cytosol annotation; the location is correct but this is a redundant duplicate of the direct-assay cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	7	R-HSA-2454264	11cROL binds to RLBP1 to form RLBP1:11cROL	yes	reactome/R-HSA-2454264.md	11cROL binds to RLBP1 to form RLBP1:11cROL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location (11cROL binds to RLBP1). Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	8	R-HSA-2465919	AWAT2 transfers PALM to 11cROL forming 11cRPALM	yes	reactome/R-HSA-2465919.md	AWAT2 transfers PALM to 11cROL forming 11cRPALM	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location. Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	9	R-HSA-2465971	RLBP1 binds atROL to form RLBP1:atROL	yes	reactome/R-HSA-2465971.md	RLBP1 binds atROL to form RLBP1:atROL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location (RLBP1 binds atROL). Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	10	R-HSA-2466832	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	yes	reactome/R-HSA-2466832.md	Defective RDH5 does not oxidise 11cROL to 11cRAL and causes RPA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location. Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	11	R-HSA-74872	RDH10,11 oxidise 11cROL to 11cRAL	yes	reactome/R-HSA-74872.md	RDH10,11 oxidise 11cROL to 11cRAL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location (RDH10,11 oxidise 11cROL to 11cRAL). Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RLBP1	genes/human/RLBP1/RLBP1-ai-review.yaml	RLBP1	P12271	NCBITaxon:9606	Homo sapiens	12	R-HSA-8960973	RLBP1:11cRAL dissociates	yes	reactome/R-HSA-8960973.md	RLBP1:11cRAL dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome reaction-derived cytosol location (RLBP1:11cRAL dissociates). Correct cytosolic location; redundant with the IDA cytosol annotation.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	21	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		REMOVE	Reactome pathway-level annotation (ABC-family transport). RNF185 is a ubiquitin ligase, not a transporter; this reflects CFTR/ABC pathway-context bleed-through.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	23	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of RNF185 (with RNF5) ubiquitinating misfolded CFTR; captures the core ligase activity.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	24	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the ERAD E3 ligase ubiquitinating an unfolded glycoprotein substrate; captures the core ligase activity.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	31	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		REMOVE	Reactome ERQC pathway annotation. RNF185 does not perform mannose trimming; this is pathway-adjacency over-annotation.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	43	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization within CFTR ERAD reactions. Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	44	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (RNF5/RNF185 ubiquitinate misfolded CFTR). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	45	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (CFTR binds ERAD machinery). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	46	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (CFTR F508del translocation). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	47	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (RNF5/RNF185 ubiquitinate CFTR F508del). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	48	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (CFTR F508del binds ERAD machinery). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	49	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization in an ERAD ubiquitination reaction. Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	50	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (CD274/PD-L1 ERAD transport). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	51	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (ubiquitination of CD274 by ERAD complex). Core compartment.
human	RNF185	genes/human/RNF185/RNF185-ai-review.yaml	RNF185	Q96GF1	NCBITaxon:9606	Homo sapiens	52	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF185 ER membrane localization (p-CD274 binds ERAD complex). Core compartment.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	22	R-HSA-1358789	Self-ubiquitination of RNF41	yes	reactome/R-HSA-1358789.md	Self-ubiquitination of RNF41	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Reactome curation (self-ubiquitination of RNF41) of ubiquitin-protein transferase activity, the core catalytic molecular function.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	36	R-HSA-1358789	Self-ubiquitination of RNF41	yes	reactome/R-HSA-1358789.md	Self-ubiquitination of RNF41	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (self-ubiquitination of RNF41). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	37	R-HSA-1358790	RNF41 ubiquitinates ERBB3	yes	reactome/R-HSA-1358790.md	RNF41 ubiquitinates ERBB3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (RNF41 ubiquitinates ERBB3). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	38	R-HSA-1358792	RNF41 ubiquitinates activated ERBB3	yes	reactome/R-HSA-1358792.md	RNF41 ubiquitinates activated ERBB3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (RNF41 ubiquitinates activated ERBB3). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	39	R-HSA-1358795	Deubiquitination of RNF41 by P-USP8	yes	reactome/R-HSA-1358795.md	Deubiquitination of RNF41 by P-USP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (deubiquitination of RNF41 by P-USP8). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	40	R-HSA-1358797	Ubiquitinated RNF41 binds P-USP8	yes	reactome/R-HSA-1358797.md	Ubiquitinated RNF41 binds P-USP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (ubiquitinated RNF41 binds P-USP8). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	41	R-HSA-1358798	RNF41 binds neuregulin-activated ERBB3	yes	reactome/R-HSA-1358798.md	RNF41 binds neuregulin-activated ERBB3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (RNF41 binds neuregulin-activated ERBB3). Consistent with the core cytosolic site of action.
human	RNF41	genes/human/RNF41/RNF41-ai-review.yaml	RNF41	Q9H4P4	NCBITaxon:9606	Homo sapiens	42	R-HSA-1358801	ERBB3 binds RNF41 ubiquitin ligase	yes	reactome/R-HSA-1358801.md	ERBB3 binds RNF41 ubiquitin ligase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (ERBB3 binds RNF41 ubiquitin ligase). Consistent with the core cytosolic site of action.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	29	R-HSA-382556	ABC-family proteins mediated transport	yes	reactome/R-HSA-382556.md	ABC-family proteins mediated transport	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		REMOVE	Reactome pathway-level annotation (ABC-family transport). RNF5 is a ubiquitin ligase, not a transporter; this reflects pathway context (CFTR/ABC transport) bleed-through.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	31	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of RNF5 (with RNF185) ubiquitinating misfolded CFTR; captures the core ligase activity.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	32	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of the ERAD E3 ligase ubiquitinating an unfolded glycoprotein substrate; captures the core ligase activity.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	43	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		REMOVE	Reactome ERQC pathway annotation. RNF5 does not perform mannose trimming; this is pathway-adjacency over-annotation.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	45	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization within CFTR ERAD reactions. Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	46	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (RNF5/RNF185 ubiquitinate misfolded CFTR). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	47	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (CFTR binds ERAD machinery). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	48	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (CFTR F508del translocation). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	49	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (RNF5/RNF185 ubiquitinate CFTR F508del). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	50	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (CFTR F508del binds ERAD machinery). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	51	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization in an ERAD ubiquitination reaction. Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	52	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (CD274/PD-L1 ERAD transport). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	53	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (ubiquitination of CD274 by ERAD complex). Core compartment.
human	RNF5	genes/human/RNF5/RNF5-ai-review.yaml	RNF5	Q99942	NCBITaxon:9606	Homo sapiens	54	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of RNF5 ER membrane localization (p-CD274 binds ERAD complex). Core compartment.
human	RORA	genes/human/RORA/RORA-ai-review.yaml	RORA	P35398	NCBITaxon:9606	Homo sapiens	35	R-HSA-376419	Formation of NR-MED1 Coactivator Complex	yes	reactome/R-HSA-376419.md	Formation of NR-MED1 Coactivator Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported nucleoplasm localization of the RORA transcription factor.
human	RORA	genes/human/RORA/RORA-ai-review.yaml	RORA	P35398	NCBITaxon:9606	Homo sapiens	36	R-HSA-382096	Formation of NR-NCOR Corepressor Complex	yes	reactome/R-HSA-382096.md	Formation of NR-NCOR Corepressor Complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported nucleoplasm localization of the RORA transcription factor.
human	RORA	genes/human/RORA/RORA-ai-review.yaml	RORA	P35398	NCBITaxon:9606	Homo sapiens	37	R-HSA-4719413	PIAS2,3,4 SUMOylate RORA with SUMO2	yes	reactome/R-HSA-4719413.md	PIAS2,3,4 SUMOylate RORA with SUMO2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported nucleoplasm localization of the RORA transcription factor.
human	RORA	genes/human/RORA/RORA-ai-review.yaml	RORA	P35398	NCBITaxon:9606	Homo sapiens	38	R-HSA-4719436	PIAS2,3,4 SUMOylate RORA with SUMO1	yes	reactome/R-HSA-4719436.md	PIAS2,3,4 SUMOylate RORA with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported nucleoplasm localization of the RORA transcription factor.
human	RORA	genes/human/RORA/RORA-ai-review.yaml	RORA	P35398	NCBITaxon:9606	Homo sapiens	39	R-HSA-6790036	Expression of STAT3-upregulated nuclear proteins	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Supported nucleoplasm localization of the RORA transcription factor.
human	RPE	genes/human/RPE/RPE-ai-review.yaml	RPE	Q96AT9	NCBITaxon:9606	Homo sapiens	16	R-HSA-199803	RPE dimers isomerize XY5P to RU5P	yes	reactome/R-HSA-199803.md	RPE dimers isomerize XY5P to RU5P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (author statement) localises RPE to the cytosol, where it catalyses the RU5P<->XY5P interconversion.
human	RPE	genes/human/RPE/RPE-ai-review.yaml	RPE	Q96AT9	NCBITaxon:9606	Homo sapiens	17	R-HSA-71303	RPE dimers isomerise RU5P to XY5P	yes	reactome/R-HSA-71303.md	RPE dimers isomerise RU5P to XY5P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (author statement) localises RPE to the cytosol for the RU5P->XY5P reaction, using Fe2+ as cofactor.
human	RPE65	genes/human/RPE65/RPE65-ai-review.yaml	RPE65	Q16518	NCBITaxon:9606	Homo sapiens	23	R-HSA-2453902	The canonical retinoid cycle in rods (twilight vision)	yes	reactome/R-HSA-2453902.md	The canonical retinoid cycle in rods (twilight vision)	Homo sapiens	GO:0001523	retinoid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation to retinoid metabolic process, based on the curated canonical retinoid (visual) cycle pathway. Correct and consistent with the IDA and IEA annotations to the same term.
human	RPE65	genes/human/RPE65/RPE65-ai-review.yaml	RPE65	Q16518	NCBITaxon:9606	Homo sapiens	27	R-HSA-2453833	RPE65 isomero-hydrolyses atREs to 11cROL	yes	reactome/R-HSA-2453833.md	RPE65 isomero-hydrolyses atREs to 11cROL	Homo sapiens	GO:0052884	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS annotation of the palmitate-specific isomerohydrolase reaction, matching the curated ""RPE65 isomero-hydrolyses atREs to 11cROL"" reaction. Correct core molecular function."
human	RPE65	genes/human/RPE65/RPE65-ai-review.yaml	RPE65	Q16518	NCBITaxon:9606	Homo sapiens	40	R-HSA-2453833	RPE65 isomero-hydrolyses atREs to 11cROL	yes	reactome/R-HSA-2453833.md	RPE65 isomero-hydrolyses atREs to 11cROL	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to plasma membrane. As with the IEA plasma-membrane call, RPE65 functions on the RPE microsomal/ER membrane rather than the plasma membrane; the Reactome reaction models RPE65 at the RPE membrane generically. Imprecise compartment assignment.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	23	R-HSA-71336	Pentose phosphate pathway	yes	reactome/R-HSA-71336.md	Pentose phosphate pathway	Homo sapiens	GO:0006098	pentose-phosphate shunt	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author annotation placing RPIA in the pentose phosphate pathway. Correct; the broader parent of the non-oxidative-branch term.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	25	R-HSA-5660013	Defective RPIA does not isomerize RU5P to R5P	yes	reactome/R-HSA-5660013.md	Defective RPIA does not isomerize RU5P to R5P	Homo sapiens	GO:0004751	ribose-5-phosphate isomerase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation of the core isomerase activity (in the context of a reaction whose defective form underlies RPIA deficiency). Correct core molecular function.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	26	R-HSA-5660015	Defective RPIA does not isomerize R5P to RU5P	yes	reactome/R-HSA-5660015.md	Defective RPIA does not isomerize R5P to RU5P	Homo sapiens	GO:0004751	ribose-5-phosphate isomerase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation of the core isomerase activity. Correct core molecular function.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	28	R-HSA-177784	RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphate	yes	reactome/R-HSA-177784.md	RPIA isomerizes ribose 5-phosphate to D-ribulose 5-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localisation of RPIA to the cytosol, consistent with its role as a soluble PPP enzyme. Core location.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	29	R-HSA-71306	RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate	yes	reactome/R-HSA-71306.md	RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localisation of RPIA to the cytosol. Core location, concordant with the other cytosol annotations.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	30	R-HSA-5660013	Defective RPIA does not isomerize RU5P to R5P	yes	reactome/R-HSA-5660013.md	Defective RPIA does not isomerize RU5P to R5P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localisation of RPIA to the cytosol. Core location.
human	RPIA	genes/human/RPIA/RPIA-ai-review.yaml	RPIA	P49247	NCBITaxon:9606	Homo sapiens	31	R-HSA-5660015	Defective RPIA does not isomerize R5P to RU5P	yes	reactome/R-HSA-5660015.md	Defective RPIA does not isomerize R5P to RU5P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localisation of RPIA to the cytosol. Core location.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	36	R-HSA-156826	Dissociation of L13a from the 60s ribosomal subunit	yes	reactome/R-HSA-156826.md	Dissociation of L13a from the 60s ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for L13a-mediated translational silencing. Cytosol is the correct localization for cytosolic ribosomal proteins.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	37	R-HSA-1799332	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome SRP-dependent cotranslational targeting pathway. Cytosol is correct for the ribosome during translation.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	38	R-HSA-1799335	Synthesis of nascent polypeptide containing signal sequence	yes	reactome/R-HSA-1799335.md	Synthesis of nascent polypeptide containing signal sequence	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for nascent polypeptide synthesis. Cytosol is correct for cytosolic ribosomes.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	39	R-HSA-192704	Synthesis of PB1-F2	yes	reactome/R-HSA-192704.md	Synthesis of PB1-F2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome viral protein synthesis pathway. Cytosol is the correct location.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	40	R-HSA-192841	Viral Protein Synthesis	yes	reactome/R-HSA-192841.md	Viral Protein Synthesis	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome viral mRNA translation pathway.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	41	R-HSA-6791218	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA	yes	reactome/R-HSA-6791218.md	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome rRNA processing pathway.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	42	R-HSA-72671	eIF5B:GTP is hydrolyzed and released	yes	reactome/R-HSA-72671.md	eIF5B:GTP is hydrolyzed and released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome translation initiation pathway (eIF5B hydrolysis).
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	43	R-HSA-72672	The 60S subunit joins the translation initiation complex	yes	reactome/R-HSA-72672.md	The 60S subunit joins the translation initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for 60S subunit joining during translation initiation.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	44	R-HSA-72673	Release of 40S and 60S subunits from the 80S ribosome	yes	reactome/R-HSA-72673.md	Release of 40S and 60S subunits from the 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for ribosomal subunit release.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	45	R-HSA-927789	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	yes	reactome/R-HSA-927789.md	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome nonsense-mediated decay pathway.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	46	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome NMD pathway (UPF1 recruitment).
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	47	R-HSA-927832	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome NMD pathway.
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	48	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome NMD pathway (SMG6 mRNA hydrolysis).
human	RPL18A	genes/human/RPL18A/RPL18A-ai-review.yaml	RPL18A	Q02543	NCBITaxon:9606	Homo sapiens	49	R-HSA-927889	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome NMD pathway (SMG1 phosphorylation).
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	27	R-HSA-156826	Dissociation of L13a from the 60s ribosomal subunit	yes	reactome/R-HSA-156826.md	Dissociation of L13a from the 60s ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	28	R-HSA-1799332	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	29	R-HSA-1799335	Synthesis of nascent polypeptide containing signal sequence	yes	reactome/R-HSA-1799335.md	Synthesis of nascent polypeptide containing signal sequence	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	30	R-HSA-192704	Synthesis of PB1-F2	yes	reactome/R-HSA-192704.md	Synthesis of PB1-F2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	31	R-HSA-192841	Viral Protein Synthesis	yes	reactome/R-HSA-192841.md	Viral Protein Synthesis	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	32	R-HSA-6791218	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA	yes	reactome/R-HSA-6791218.md	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	33	R-HSA-72671	eIF5B:GTP is hydrolyzed and released	yes	reactome/R-HSA-72671.md	eIF5B:GTP is hydrolyzed and released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	34	R-HSA-72672	The 60S subunit joins the translation initiation complex	yes	reactome/R-HSA-72672.md	The 60S subunit joins the translation initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	35	R-HSA-72673	Release of 40S and 60S subunits from the 80S ribosome	yes	reactome/R-HSA-72673.md	Release of 40S and 60S subunits from the 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	36	R-HSA-927789	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	yes	reactome/R-HSA-927789.md	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	37	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	38	R-HSA-927832	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	39	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	40	R-HSA-927889	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	41	R-HSA-9948291	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948291.md	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	42	R-HSA-9948300	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	43	R-HSA-9948301	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	yes	reactome/R-HSA-9948301.md	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	44	R-HSA-9948317	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome	yes	reactome/R-HSA-9948317.md	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	45	R-HSA-9948318	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala	yes	reactome/R-HSA-9948318.md	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	46	R-HSA-9948360	NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948360.md	NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	47	R-HSA-9948362	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948362.md	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	48	R-HSA-9948427	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	49	R-HSA-9948458	"NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide (""CAT tailing"")"	yes	reactome/R-HSA-9948458.md	"NEMF polymerizes alanine residues onto the C-terminus of the nascent peptide (""CAT tailing"")"	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	50	R-HSA-9954723	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	yes	reactome/R-HSA-9954723.md	NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	51	R-HSA-9954727	RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2	yes	reactome/R-HSA-9954727.md	RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	52	R-HSA-9954730	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9954730.md	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	53	R-HSA-9954919	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPL36A	genes/human/RPL36A/RPL36A-ai-review.yaml	RPL36A	P83881	NCBITaxon:9606	Homo sapiens	54	R-HSA-9955731	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9955731.md	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	RPL36A is a cytoplasmic/cytosolic ribosomal protein.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	37	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing RPN1 in the ER membrane (N-glycan transfer reaction). Correct core localization.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	38	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral spike protein N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization; the viral-substrate pathway context is incidental.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	39	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (CDH1 N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	40	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral E protein N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	41	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral pre-M N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	42	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral pre-NS1 N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization.
human	RPN1	genes/human/RPN1/RPN1-ai-review.yaml	RPN1	P04843	NCBITaxon:9606	Homo sapiens	43	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (CD274/PD-L1 N-glycosylation reaction) placing RPN1 in the ER membrane. Correct localization.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	25	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS ER-membrane location from the Reactome reaction ""Transfer of N-glycan to the protein"", in which the OST complex (including RPN2) acts at the ER membrane. Correct core location; redundant with the IEA/NAS ER-membrane annotations. Kept as non-core."
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	26	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (viral spike protein glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	27	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (CDH1 glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	28	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (viral E protein glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	29	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (pre-M protein glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	30	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (pre-NS1 folding/glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPN2	genes/human/RPN2/RPN2-ai-review.yaml	RPN2	P04844	NCBITaxon:9606	Homo sapiens	31	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS ER-membrane location from a Reactome N-glycosylation reaction record (CD274/PD-L1 glycosylation). Correct location but a substrate-specific pathway instance; redundant with the primary ER-membrane annotations. Kept as non-core.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	112	R-HSA-6791223	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	yes	reactome/R-HSA-6791223.md	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places RPS3 in the nucleoplasm in the context of pre-40S particle processing during ribosome biogenesis (pre-rRNA processing en route from nucleus to cytosol).
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	145	R-HSA-156808	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	yes	reactome/R-HSA-156808.md	Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	146	R-HSA-156823	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	yes	reactome/R-HSA-156823.md	Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	147	R-HSA-157849	Formation of translation initiation complexes containing mRNA that does not circularize	yes	reactome/R-HSA-157849.md	Formation of translation initiation complexes containing mRNA that does not circularize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	148	R-HSA-1799332	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	149	R-HSA-1799335	Synthesis of nascent polypeptide containing signal sequence	yes	reactome/R-HSA-1799335.md	Synthesis of nascent polypeptide containing signal sequence	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	150	R-HSA-192704	Synthesis of PB1-F2	yes	reactome/R-HSA-192704.md	Synthesis of PB1-F2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	151	R-HSA-192841	Viral Protein Synthesis	yes	reactome/R-HSA-192841.md	Viral Protein Synthesis	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	152	R-HSA-6791223	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	yes	reactome/R-HSA-6791223.md	18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a pre-40S/40S ribosome component) in the cytosol in the context of pre-rRNA processing during nucleus-to-cytosol translocation of pre-40S particles.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	153	R-HSA-72619	eIF2:GTP is hydrolyzed, eIFs are released	yes	reactome/R-HSA-72619.md	eIF2:GTP is hydrolyzed, eIFs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	154	R-HSA-72621	Ribosomal scanning	yes	reactome/R-HSA-72621.md	Ribosomal scanning	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	155	R-HSA-72671	eIF5B:GTP is hydrolyzed and released	yes	reactome/R-HSA-72671.md	eIF5B:GTP is hydrolyzed and released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	156	R-HSA-72672	The 60S subunit joins the translation initiation complex	yes	reactome/R-HSA-72672.md	The 60S subunit joins the translation initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	157	R-HSA-72673	Release of 40S and 60S subunits from the 80S ribosome	yes	reactome/R-HSA-72673.md	Release of 40S and 60S subunits from the 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	158	R-HSA-72676	eIF3 and eIF1A bind to the 40S subunit	yes	reactome/R-HSA-72676.md	eIF3 and eIF1A bind to the 40S subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	159	R-HSA-72691	Formation of the 43S pre-initiation complex	yes	reactome/R-HSA-72691.md	Formation of the 43S pre-initiation complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	160	R-HSA-72697	Start codon recognition	yes	reactome/R-HSA-72697.md	Start codon recognition	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	161	R-HSA-927789	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	yes	reactome/R-HSA-927789.md	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	162	R-HSA-927813	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	163	R-HSA-927832	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	164	R-HSA-927836	SMG6 hydrolyzes mRNA with premature termination codon	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	165	R-HSA-927889	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	166	R-HSA-9729232	SARS-CoV-1 nsp1 binds to 40S ribosomal subunit	yes	reactome/R-HSA-9729232.md	SARS-CoV-1 nsp1 binds to 40S ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	167	R-HSA-9729849	SARS-CoV-2 nsp1 binds to 40S ribosomal complex	yes	reactome/R-HSA-9729849.md	SARS-CoV-2 nsp1 binds to 40S ribosomal complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	168	R-HSA-9948291	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948291.md	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	169	R-HSA-9948300	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	170	R-HSA-9948301	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	yes	reactome/R-HSA-9948301.md	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	171	R-HSA-9948317	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome	yes	reactome/R-HSA-9948317.md	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	172	R-HSA-9954730	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9954730.md	PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	173	R-HSA-9954919	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	yes	reactome/R-HSA-9954919.md	ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RPS3	genes/human/RPS3/RPS3-ai-review.yaml	RPS3	P23396	NCBITaxon:9606	Homo sapiens	174	R-HSA-9955731	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	yes	reactome/R-HSA-9955731.md	ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places RPS3 (as a 40S/cytosolic ribosome component) in the cytosol within this translation/ribosome-associated pathway step.
human	RRM2B	genes/human/RRM2B/RRM2B-ai-review.yaml	RRM2B	Q7LG56	NCBITaxon:9606	Homo sapiens	43	R-HSA-111804	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)	yes	reactome/R-HSA-111804.md	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the RNR (M1M2B) NDP->dNDP reaction (thioredoxin) in the cytosol.
human	RRM2B	genes/human/RRM2B/RRM2B-ai-review.yaml	RRM2B	Q7LG56	NCBITaxon:9606	Homo sapiens	44	R-HSA-5632892	TP53 stimulates transcription of RRM2B gene	yes	reactome/R-HSA-5632892.md	TP53 stimulates transcription of RRM2B gene	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement (TP53 stimulates transcription of RRM2B) placing RRM2B in the cytosol.
human	RRM2B	genes/human/RRM2B/RRM2B-ai-review.yaml	RRM2B	Q7LG56	NCBITaxon:9606	Homo sapiens	45	R-HSA-8866405	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)	yes	reactome/R-HSA-8866405.md	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the RNR (M1M2B) NDP->dNDP reaction (glutaredoxin) in the cytosol.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	32	R-HSA-8952419	SMURFs ubiquitinate RUNX3	yes	reactome/R-HSA-8952419.md	SMURFs ubiquitinate RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	33	R-HSA-8952399	Polyubiquitinated RUNX3 translocates to the cytosol	yes	reactome/R-HSA-8952399.md	Polyubiquitinated RUNX3 translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol localization is supported, but mainly as a mislocalization/export or degradation context rather than the canonical site of RUNX3 function.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	34	R-HSA-8952408	Polyubiquitinated RUNX3 is degraded by the proteasome	yes	reactome/R-HSA-8952408.md	Polyubiquitinated RUNX3 is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol localization is supported, but mainly as a mislocalization/export or degradation context rather than the canonical site of RUNX3 function.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	35	R-HSA-8952382	MDM2 polyubiquitinates RUNX3	yes	reactome/R-HSA-8952382.md	MDM2 polyubiquitinates RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	36	R-HSA-8952399	Polyubiquitinated RUNX3 translocates to the cytosol	yes	reactome/R-HSA-8952399.md	Polyubiquitinated RUNX3 translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	37	R-HSA-8951966	EP300 acetylates RUNX3	yes	reactome/R-HSA-8951966.md	EP300 acetylates RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	38	R-HSA-8951977	Acetylated RUNX3 binds to BRD2	yes	reactome/R-HSA-8951977.md	Acetylated RUNX3 binds to BRD2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	39	R-HSA-8952058	CCND1 binds RUNX3 and displaces EP300	yes	reactome/R-HSA-8952058.md	CCND1 binds RUNX3 and displaces EP300	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	40	R-HSA-8952062	CCND1 recruits HDAC4 to RUNX3	yes	reactome/R-HSA-8952062.md	CCND1 recruits HDAC4 to RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	41	R-HSA-8952069	HDAC4 deacetylates RUNX3	yes	reactome/R-HSA-8952069.md	HDAC4 deacetylates RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	42	R-HSA-8937792	RUNX3 binds SRC	yes	reactome/R-HSA-8937792.md	RUNX3 binds SRC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol localization is supported, but mainly as a mislocalization/export or degradation context rather than the canonical site of RUNX3 function.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	43	R-HSA-8937807	SRC phosphorylates RUNX3	yes	reactome/R-HSA-8937807.md	SRC phosphorylates RUNX3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol localization is supported, but mainly as a mislocalization/export or degradation context rather than the canonical site of RUNX3 function.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	44	R-HSA-8937814	RUNX3 translocates to the nucleus	yes	reactome/R-HSA-8937814.md	RUNX3 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol localization is supported, but mainly as a mislocalization/export or degradation context rather than the canonical site of RUNX3 function.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	45	R-HSA-8865454	CBFB binds RUNX3	yes	reactome/R-HSA-8865454.md	CBFB binds RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	46	R-HSA-8878117	RUNX3 binds ZFHX3	yes	reactome/R-HSA-8878117.md	RUNX3 binds ZFHX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	47	R-HSA-8878143	RUNX3 binds SMAD3 and SMAD4	yes	reactome/R-HSA-8878143.md	RUNX3 binds SMAD3 and SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	48	R-HSA-8878178	The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter	yes	reactome/R-HSA-8878178.md	The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	49	R-HSA-8878193	RUNX3 binds the JAG1 gene promoter	yes	reactome/R-HSA-8878193.md	RUNX3 binds the JAG1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	50	R-HSA-8878220	RUNX3 binds the NOTCH1 coactivator complex	yes	reactome/R-HSA-8878220.md	RUNX3 binds the NOTCH1 coactivator complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	51	R-HSA-8878237	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	yes	reactome/R-HSA-8878237.md	RUNX3:NOTCH1 coactivator complex binds the HES1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	52	R-HSA-8937814	RUNX3 translocates to the nucleus	yes	reactome/R-HSA-8937814.md	RUNX3 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	53	R-HSA-8949335	RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter	yes	reactome/R-HSA-8949335.md	RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	54	R-HSA-8951428	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)	yes	reactome/R-HSA-8951428.md	RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	55	R-HSA-8951676	RUNX3 binds TEADs and YAP1	yes	reactome/R-HSA-8951676.md	RUNX3 binds TEADs and YAP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	56	R-HSA-8951910	RUNX3 binds the RUNX1 promoter	yes	reactome/R-HSA-8951910.md	RUNX3 binds the RUNX1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	57	R-HSA-8951951	RUNX3 binds EP300	yes	reactome/R-HSA-8951951.md	RUNX3 binds EP300	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	58	R-HSA-8952128	RUNX3 binds TP53	yes	reactome/R-HSA-8952128.md	RUNX3 binds TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	59	R-HSA-8952226	RUNX3 binds the BCL2L11 (BIM) gene	yes	reactome/R-HSA-8952226.md	RUNX3 binds the BCL2L11 (BIM) gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	RUNX3	genes/human/RUNX3/RUNX3-ai-review.yaml	RUNX3	Q13761	NCBITaxon:9606	Homo sapiens	60	R-HSA-8952371	MDM2 binds RUNX3	yes	reactome/R-HSA-8952371.md	MDM2 binds RUNX3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization is central to RUNX3 canonical transcription factor activity.
human	SAMD8	genes/human/SAMD8/SAMD8-ai-review.yaml	SAMD8	Q96LT4	NCBITaxon:9606	Homo sapiens	15	R-HSA-8959462	SAMD8 transfers phosphatidyl from PE onto C16DH CER	yes	reactome/R-HSA-8959462.md	SAMD8 transfers phosphatidyl from PE onto C16DH CER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct annotation from Reactome pathway curation. SAMD8 is an ER membrane protein that catalyzes CPE synthesis in the ER (PMID:19506037).
human	SAT1	genes/human/SAT1/SAT1-ai-review.yaml	SAT1	P21673	NCBITaxon:9606	Homo sapiens	20	R-HSA-351200	Interconversion of polyamines	yes	reactome/R-HSA-351200.md	Interconversion of polyamines	Homo sapiens	GO:0006596	polyamine biosynthetic process	TAS	involved_in	BP	false		MODIFY	"This TAS annotation comes from the Reactome ""Interconversion of polyamines"" pathway, which describes back-conversion (spermine -> spermidine -> putrescine) via SAT1-mediated N1-acetylation followed by oxidation. That is a catabolic/interconversion process, not biosynthesis; the mapping to polyamine BIOSYNTHETIC process is the wrong pathway direction. Modify to polyamine catabolic process."
human	SAT1	genes/human/SAT1/SAT1-ai-review.yaml	SAT1	P21673	NCBITaxon:9606	Homo sapiens	22	R-HSA-351207	Spermine => N-acetylated spermine	yes	reactome/R-HSA-351207.md	Spermine => N-acetylated spermine	Homo sapiens	GO:0004145	diamine N-acetyltransferase activity	TAS	enables	MF	false		ACCEPT	"TAS annotation (Reactome ""Spermine => N-acetylated spermine"") of the core catalytic activity: SAT1 acetylates spermine to N-acetylspermine, the rate-limiting step of polyamine catabolism. Accept as a core molecular function."
human	SAT1	genes/human/SAT1/SAT1-ai-review.yaml	SAT1	P21673	NCBITaxon:9606	Homo sapiens	23	R-HSA-351208	Spermidine => N-acetylated spermidine	yes	reactome/R-HSA-351208.md	Spermidine => N-acetylated spermidine	Homo sapiens	GO:0004145	diamine N-acetyltransferase activity	TAS	enables	MF	false		ACCEPT	"TAS annotation (Reactome ""Spermidine => N-acetylated spermidine"") of the core catalytic activity: SAT1 acetylates spermidine to N-acetylspermidine. Accept as a core molecular function."
human	SAT1	genes/human/SAT1/SAT1-ai-review.yaml	SAT1	P21673	NCBITaxon:9606	Homo sapiens	29	R-HSA-351207	Spermine => N-acetylated spermine	yes	reactome/R-HSA-351207.md	Spermine => N-acetylated spermine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to cytosol, consistent with the curated UniProt location and the enzyme's cytosolic acetyl-CoA-dependent activity. Accept as the core localization.
human	SAT1	genes/human/SAT1/SAT1-ai-review.yaml	SAT1	P21673	NCBITaxon:9606	Homo sapiens	30	R-HSA-351208	Spermidine => N-acetylated spermidine	yes	reactome/R-HSA-351208.md	Spermidine => N-acetylated spermidine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) localization to cytosol, duplicate of the R-HSA-351207 call and consistent with the UniProt curated location. Accept as the core localization.
human	SC5D	genes/human/SC5D/SC5D-ai-review.yaml	SC5D	O75845	NCBITaxon:9606	Homo sapiens	10	R-HSA-6807047	Cholesterol biosynthesis via desmosterol (Bloch pathway)	yes	reactome/R-HSA-6807047.md	Cholesterol biosynthesis via desmosterol (Bloch pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of SC5D in cholesterol biosynthesis via the desmosterol/Bloch pathway. Correct: SC5D also desaturates the Bloch-arm intermediate 5alpha-cholesta-7,24-dien-3beta-ol.
human	SC5D	genes/human/SC5D/SC5D-ai-review.yaml	SC5D	O75845	NCBITaxon:9606	Homo sapiens	11	R-HSA-9969901	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	yes	reactome/R-HSA-9969901.md	Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)	Homo sapiens	GO:0006695	cholesterol biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of SC5D in cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway), the lathosterol arm in which SC5D acts. Correct core biological process.
human	SC5D	genes/human/SC5D/SC5D-ai-review.yaml	SC5D	O75845	NCBITaxon:9606	Homo sapiens	20	R-HSA-1655852	Expression of Lathosterol Oxidase (SC5D, SC5DL)	yes	reactome/R-HSA-1655852.md	Expression of Lathosterol Oxidase (SC5D, SC5DL)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization associated with expression of lathosterol oxidase (SC5D). Consistent with the experimental IDA and the multi-pass membrane topology.
human	SC5D	genes/human/SC5D/SC5D-ai-review.yaml	SC5D	O75845	NCBITaxon:9606	Homo sapiens	21	R-HSA-195664	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol	yes	reactome/R-HSA-195664.md	Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization for the SC5D-catalyzed desaturation of cholesta-7,24-dien-3beta-ol (a Bloch-arm reaction). Consistent with the established ER location.
human	SC5D	genes/human/SC5D/SC5D-ai-review.yaml	SC5D	O75845	NCBITaxon:9606	Homo sapiens	22	R-HSA-6807053	SC5D desaturates LTHSOL to 7-dehydroCHOL	yes	reactome/R-HSA-6807053.md	SC5D desaturates LTHSOL to 7-dehydroCHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) ER-membrane localization for the SC5D reaction that desaturates lathosterol to 7-dehydrocholesterol. Consistent with the experimental and predicted ER-membrane location.
human	SCAMP1	genes/human/SCAMP1/SCAMP1-ai-review.yaml	SCAMP1	O15126	NCBITaxon:9606	Homo sapiens	22	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane from Reactome neutrophil degranulation pathway. SCAMP1 cycles between intracellular compartments and the plasma membrane.
human	SCAMP1	genes/human/SCAMP1/SCAMP1-ai-review.yaml	SCAMP1	O15126	NCBITaxon:9606	Homo sapiens	23	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for specific granule membrane from Reactome. Specific granules are secondary granules in neutrophils containing antimicrobial substances.
human	SCO1	genes/human/SCO1/SCO1-ai-review.yaml	SCO1	O75880	NCBITaxon:9606	Homo sapiens	13	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	SCO1 is a single-pass mitochondrial inner membrane protein with its functional domain exposed for COX2 maturation.
human	SCO1	genes/human/SCO1/SCO1-ai-review.yaml	SCO1	O75880	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	SCO1 is a single-pass mitochondrial inner membrane protein with its functional domain exposed for COX2 maturation.
human	SCO1	genes/human/SCO1/SCO1-ai-review.yaml	SCO1	O75880	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	SCO1 is a single-pass mitochondrial inner membrane protein with its functional domain exposed for COX2 maturation.
human	SCO2	genes/human/SCO2/SCO2-ai-review.yaml	SCO2	O43819	NCBITaxon:9606	Homo sapiens	14	R-HSA-5632766	TP53 stimulates SCO2 gene transcription	yes	reactome/R-HSA-5632766.md	TP53 stimulates SCO2 gene transcription	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"This TAS annotation derives from the Reactome pathway entry for TP53-stimulated SCO2 transcription. The Reactome entry describes SCO2 as a ""copper-binding assembly protein"" that localizes to the mitochondrial inner membrane. This is consistent with experimental evidence (PMID:15229189)."
human	SCO2	genes/human/SCO2/SCO2-ai-review.yaml	SCO2	O43819	NCBITaxon:9606	Homo sapiens	15	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This TAS annotation derives from the Reactome pathway entry describing the metallochaperone complex that inserts Cu2+ into MT-CO1. The Reactome entry describes SCO2 as part of a nine-subunit metallochaperone complex on the inner mitochondrial membrane. Note that SCO2's primary role is copper delivery to COX2 (CuA site), not COX1 (CuB site). The Reactome entry groups SCO2 into a broader metallochaperone complex that may be somewhat oversimplified.
human	SCO2	genes/human/SCO2/SCO2-ai-review.yaml	SCO2	O43819	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This TAS annotation derives from the Reactome pathway entry describing the association of MT-CO1 and MT-CO2 complexes with heme moiety installation. The Reactome entry describes SCO2 as part of the COX2-specific copper chaperone module (with COA6 and SCO1). The localization to the mitochondrial inner membrane is correct.
human	SCO2	genes/human/SCO2/SCO2-ai-review.yaml	SCO2	O43819	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865630	Metallochaperone inserts 2Cu2+ into MT-CO2	yes	reactome/R-HSA-9865630.md	Metallochaperone inserts 2Cu2+ into MT-CO2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This TAS annotation derives from the Reactome pathway entry describing copper insertion into MT-CO2 (the CuA site). This is the most directly relevant Reactome entry for SCO2's function, as it describes the specific step SCO2 participates in. The localization to the mitochondrial inner membrane is correct.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	19	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Bile acid biosynthetic process (Reactome). SCPx performs the peroxisomal thiolytic side-chain cleavage of C27 bile-acid intermediates (DHCA/THCA) that yields the mature C24 bile acids. A core biological process.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	20	R-HSA-389887	Beta-oxidation of pristanoyl-CoA	yes	reactome/R-HSA-389887.md	Beta-oxidation of pristanoyl-CoA	Homo sapiens	GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Peroxisomal (acyl-CoA-oxidase) beta-oxidation of pristanoyl-CoA (Reactome). SCPx provides the thiolase step of this pathway. Correct; more specific than the generic fatty acid beta-oxidation term. Non-core specialization of the beta-oxidation role.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	21	R-HSA-2046106	alpha-linolenic acid (ALA) metabolism	yes	reactome/R-HSA-2046106.md	alpha-linolenic acid (ALA) metabolism	Homo sapiens	GO:0036109	alpha-linolenic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Alpha-linolenic acid (ALA) metabolism (Reactome), reflecting SCPx's role in the peroxisomal beta-oxidation of C24:6n-3 during DHA synthesis. A genuine but peripheral contribution; non-core.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	35	R-HSA-192341	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	yes	reactome/R-HSA-192341.md	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	Homo sapiens	GO:0050632	propionyl-CoA C2-trimethyltridecanoyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the SCPx-catalyzed thiolytic step (trihydroxy-cholestanoyl thiolysis to choloyl-CoA + propionyl-CoA). Supports the core thiolase MF.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	36	R-HSA-193533	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	yes	reactome/R-HSA-193533.md	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	Homo sapiens	GO:0050632	propionyl-CoA C2-trimethyltridecanoyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the analogous SCPx thiolytic step in chenodeoxycholoyl-CoA formation. Supports the core thiolase MF.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	39	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol (Reactome) — the compartment from which PEX5 cargo (including SCP2) translocates into the peroxisomal matrix. Correct pre-import location; non-core.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	40	R-HSA-9033236	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	yes	reactome/R-HSA-9033236.md	PEX5S,L:Cargo binds PEX13:PEX14:PEX2:PEX10:PEX12 (Docking and Translocation Module)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosol (Reactome), from the PEX5:cargo docking-complex step. Correct pre-import location; non-core. Redundant with the other cytosol annotation.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	42	R-HSA-192341	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	yes	reactome/R-HSA-192341.md	Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix (Reactome) — the precise compartment where the SCPx thiolase and imported SCP2 act. A more specific and accurate version of the peroxisome localization; core.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	43	R-HSA-193533	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	yes	reactome/R-HSA-193533.md	Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix (Reactome), same accurate compartment. Redundant with the other peroxisomal matrix annotations; core.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	44	R-HSA-390224	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA	yes	reactome/R-HSA-390224.md	3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix (Reactome), from the 3-ketopristanoyl-CoA thiolysis step. Accurate core compartment; redundant.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	56	R-HSA-2066781	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)	yes	reactome/R-HSA-2066781.md	Formation of DHA-CoA catalysed by sterol carrier protein X (SCPx)	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix (Reactome), from the DHA-CoA formation step catalyzed by SCPx. Accurate core compartment; redundant.
human	SCP2	genes/human/SCP2/SCP2-ai-review.yaml	SCP2	P22307	NCBITaxon:9606	Homo sapiens	57	R-HSA-9033235	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	yes	reactome/R-HSA-9033235.md	Cargo of PEX5S,L translocates from the cytosol to the peroxisomal matrix	Homo sapiens	GO:0005782	peroxisomal matrix	TAS	located_in	CC	false		ACCEPT	Peroxisomal matrix (Reactome), the destination of PEX5 cargo translocation. Accurate core compartment; redundant with other peroxisomal matrix annotations.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	33	R-HSA-71403	Citric acid cycle (TCA cycle)	yes	reactome/R-HSA-71403.md	Citric acid cycle (TCA cycle)	Homo sapiens	GO:0006099	tricarboxylic acid cycle	TAS	involved_in	BP	false		ACCEPT	TAS annotation from Reactome TCA cycle pathway. SDHA participates in the TCA cycle by catalyzing the succinate to fumarate step.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	38	R-HSA-9854672	FAD attaches to SDHA	yes	reactome/R-HSA-9854672.md	FAD attaches to SDHA	Homo sapiens	GO:0071949	FAD binding	TAS	enables	MF	false		ACCEPT	TAS annotation from Reactome for FAD binding. The Reactome entry R-HSA-9854672 describes the covalent attachment of FAD to SDHA. GO:0071949 (FAD binding) specifically refers to binding the oxidized form of FAD, which is appropriate for SDHA.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	43	R-HSA-70994	SDH complex dehydrogenates succinate	yes	reactome/R-HSA-70994.md	SDH complex dehydrogenates succinate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for mitochondrial matrix localization. The Reactome entry describes the SDH complex dehydrogenation of succinate, placing SDHA in the matrix.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	44	R-HSA-9854672	FAD attaches to SDHA	yes	reactome/R-HSA-9854672.md	FAD attaches to SDHA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with the FAD attachment to SDHA reaction which occurs in the matrix.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	45	R-HSA-9854961	SDHAF4 binds to FAD-SDHA	yes	reactome/R-HSA-9854961.md	SDHAF4 binds to FAD-SDHA	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with SDHAF4 binding to FAD-SDHA.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	46	R-HSA-9855212	SDHA binds to SDHB	yes	reactome/R-HSA-9855212.md	SDHA binds to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with SDHA binding to SDHB.
human	SDHA	genes/human/SDHA/SDHA-ai-review.yaml	SDHA	P31040	NCBITaxon:9606	Homo sapiens	47	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with SDHA:SDHB binding to SDHC:SDHD.
human	SDHAF1	genes/human/SDHAF1/SDHAF1-ai-review.yaml	SDHAF1	A6NFY7	NCBITaxon:9606	Homo sapiens	13	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization within the SDH assembly pathway (Transfer of Fe-S clusters to SDHB). Matches the curated UniProt matrix location. Accepted.
human	SDHAF1	genes/human/SDHAF1/SDHAF1-ai-review.yaml	SDHAF1	A6NFY7	NCBITaxon:9606	Homo sapiens	14	R-HSA-9855212	SDHA binds to SDHB	yes	reactome/R-HSA-9855212.md	SDHA binds to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization (SDHA binds to SDHB reaction). Correct, specific compartment consistent with UniProt. Accepted.
human	SDHAF1	genes/human/SDHAF1/SDHAF1-ai-review.yaml	SDHAF1	A6NFY7	NCBITaxon:9606	Homo sapiens	15	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) matrix localization (SDHA:SDHB binds to SDHC:SDHD reaction). Correct, specific compartment consistent with UniProt. Accepted.
human	SDHB	genes/human/SDHB/SDHB-ai-review.yaml	SDHB	P21912	NCBITaxon:9606	Homo sapiens	34	R-HSA-9854984	Transfer of Fe-S clusters to SDHB	yes	reactome/R-HSA-9854984.md	Transfer of Fe-S clusters to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for mitochondrial matrix localization. The Reactome entry R-HSA-9854984 describes the transfer of Fe-S clusters to SDHB, which occurs in the mitochondrial matrix.
human	SDHB	genes/human/SDHB/SDHB-ai-review.yaml	SDHB	P21912	NCBITaxon:9606	Homo sapiens	35	R-HSA-9855212	SDHA binds to SDHB	yes	reactome/R-HSA-9855212.md	SDHA binds to SDHB	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for matrix localization, associated with SDHA binding to SDHB. The SDHA-SDHB subcomplex formation occurs in the matrix.
human	SDHB	genes/human/SDHB/SDHB-ai-review.yaml	SDHB	P21912	NCBITaxon:9606	Homo sapiens	36	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for matrix localization, associated with SDHA:SDHB binding to SDHC:SDHD. The final assembly step of Complex II.
human	SDHB	genes/human/SDHB/SDHB-ai-review.yaml	SDHB	P21912	NCBITaxon:9606	Homo sapiens	39	R-HSA-70994	SDH complex dehydrogenates succinate	yes	reactome/R-HSA-70994.md	SDH complex dehydrogenates succinate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for inner membrane localization. Reactome entry R-HSA-70994 describes the SDH complex dehydrogenation of succinate, placing SDHB at the inner mitochondrial membrane.
human	SDHB	genes/human/SDHB/SDHB-ai-review.yaml	SDHB	P21912	NCBITaxon:9606	Homo sapiens	40	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for inner membrane localization. Reactome entry R-HSA-9855252 describes SDHA:SDHB binding to SDHC:SDHD at the inner membrane.
human	SDHC	genes/human/SDHC/SDHC-ai-review.yaml	SDHC	Q99643	NCBITaxon:9606	Homo sapiens	21	R-HSA-70994	SDH complex dehydrogenates succinate	yes	reactome/R-HSA-70994.md	SDH complex dehydrogenates succinate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for inner mitochondrial membrane localization from Reactome pathway R-HSA-70994 (SDH complex dehydrogenates succinate). Reactome models Complex II as located in the inner mitochondrial membrane where it catalyzes the oxidation of succinate coupled to ubiquinone reduction.
human	SDHC	genes/human/SDHC/SDHC-ai-review.yaml	SDHC	Q99643	NCBITaxon:9606	Homo sapiens	22	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for inner mitochondrial membrane localization from Reactome pathway R-HSA-9855252 (SDHA:SDHB binds to SDHC:SDHD). This Reactome entry models the assembly of Complex II by association of the catalytic SDHA:SDHB subcomplex with the membrane-anchored SDHC:SDHD subcomplex at the inner mitochondrial membrane.
human	SDHD	genes/human/SDHD/SDHD-ai-review.yaml	SDHD	O14521	NCBITaxon:9606	Homo sapiens	24	R-HSA-70994	SDH complex dehydrogenates succinate	yes	reactome/R-HSA-70994.md	SDH complex dehydrogenates succinate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-70994 (SDH complex dehydrogenates succinate). SDHD is placed in the inner mitochondrial membrane as part of the SDH complex in this Reactome reaction.
human	SDHD	genes/human/SDHD/SDHD-ai-review.yaml	SDHD	O14521	NCBITaxon:9606	Homo sapiens	25	R-HSA-9855252	SDHA:SDHB binds to SDHC:SDHD	yes	reactome/R-HSA-9855252.md	SDHA:SDHB binds to SDHC:SDHD	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9855252 (SDHA:SDHB binds to SDHC:SDHD). This Reactome reaction describes the assembly of the SDHA/SDHB catalytic dimer with the SDHC/SDHD membrane anchor in the inner mitochondrial membrane.
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	13	R-HSA-9829030	Nascent F signal peptide is cleaved at ER membrane	yes	reactome/R-HSA-9829030.md	Nascent F signal peptide is cleaved at ER membrane	Homo sapiens	GO:0004252	serine-type endopeptidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of SEC11A serine-endopeptidase activity (cleavage of a viral fusion-protein signal peptide at the ER membrane); consistent with its core catalytic function.
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	14	R-HSA-9932162	Removal of CDH1 signal peptide	yes	reactome/R-HSA-9932162.md	Removal of CDH1 signal peptide	Homo sapiens	GO:0004252	serine-type endopeptidase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of SEC11A serine-endopeptidase activity (removal of the CDH1 signal peptide); consistent with its core catalytic function.
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	20	R-HSA-9820965	Respiratory syncytial virus (RSV) genome replication, transcription and translation	yes	reactome/R-HSA-9820965.md	Respiratory syncytial virus (RSV) genome replication, transcription and translation	Homo sapiens	GO:0009615	response to virus	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome annotation arising because SEC11A signal peptidase processes viral (e.g. RSV) polyprotein signal peptides during the viral life cycle. This is a downstream consequence of its general signal peptidase activity on viral substrates, not a dedicated antiviral/host-response function.
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	24	R-HSA-422051	Cleavage of the signal peptide of Preproghrelin	yes	reactome/R-HSA-422051.md	Cleavage of the signal peptide of Preproghrelin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11A ER membrane localization (preproghrelin signal peptide cleavage).
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	25	R-HSA-9918795	Signalase cleaves prM-E-NS1-NS2A	yes	reactome/R-HSA-9918795.md	Signalase cleaves prM-E-NS1-NS2A	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11A ER membrane localization (flaviviral polyprotein signalase cleavage).
human	SEC11A	genes/human/SEC11A/SEC11A-ai-review.yaml	SEC11A	P67812	NCBITaxon:9606	Homo sapiens	26	R-HSA-9918871	Signalase cleaves prepro-NS4B	yes	reactome/R-HSA-9918871.md	Signalase cleaves prepro-NS4B	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11A ER membrane localization (NS4B signalase cleavage).
human	SEC11C	genes/human/SEC11C/SEC11C-ai-review.yaml	SEC11C	Q9BY50	NCBITaxon:9606	Homo sapiens	22	R-HSA-422051	Cleavage of the signal peptide of Preproghrelin	yes	reactome/R-HSA-422051.md	Cleavage of the signal peptide of Preproghrelin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11C ER membrane localization (preproghrelin signal peptide cleavage).
human	SEC11C	genes/human/SEC11C/SEC11C-ai-review.yaml	SEC11C	Q9BY50	NCBITaxon:9606	Homo sapiens	23	R-HSA-9918795	Signalase cleaves prM-E-NS1-NS2A	yes	reactome/R-HSA-9918795.md	Signalase cleaves prM-E-NS1-NS2A	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11C ER membrane localization (flaviviral polyprotein signalase cleavage).
human	SEC11C	genes/human/SEC11C/SEC11C-ai-review.yaml	SEC11C	Q9BY50	NCBITaxon:9606	Homo sapiens	24	R-HSA-9918871	Signalase cleaves prepro-NS4B	yes	reactome/R-HSA-9918871.md	Signalase cleaves prepro-NS4B	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SEC11C ER membrane localization (NS4B signalase cleavage).
human	SELENOI	genes/human/SELENOI/SELENOI-ai-review.yaml	SELENOI	Q9C0D9	NCBITaxon:9606	Homo sapiens	24	R-HSA-1482962	CDP-ETA and DAG are converted to PE by CEPT1/EPT1	yes	reactome/R-HSA-1482962.md	CDP-ETA and DAG are converted to PE by CEPT1/EPT1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curated statement placing the CEPT1/EPT1 reaction at the endoplasmic reticulum membrane. Consistent with the core ER-membrane localization.
human	SEPHS2	genes/human/SEPHS2/SEPHS2-ai-review.yaml	SEPHS2	Q99611	NCBITaxon:9606	Homo sapiens	9	R-HSA-2408557	Selenocysteine synthesis	no				GO:0016260	L-selenocysteine biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of SEPHS2 in the 'Selenocysteine synthesis' pathway, corresponding to the core biological process. Concordant with experimental evidence. Accept.
human	SEPHS2	genes/human/SEPHS2/SEPHS2-ai-review.yaml	SEPHS2	Q99611	NCBITaxon:9606	Homo sapiens	10	R-HSA-8959510	SEPHS2 phosphorylates H2Se to form SELP	no				GO:0004756	selenide, water dikinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core catalytic function, representing the reaction in which SEPHS2 converts selenide (H2Se) to selenophosphate. Concordant with UniProt and the human enzymology. Accept.
human	SEPHS2	genes/human/SEPHS2/SEPHS2-ai-review.yaml	SEPHS2	Q99611	NCBITaxon:9606	Homo sapiens	14	R-HSA-8959510	SEPHS2 phosphorylates H2Se to form SELP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization for the SEPHS2 reaction. Consistent with the IDA cytoplasm annotation and the soluble enzyme; cytosol is a more precise cellular location. Accept.
human	SEPSECS	genes/human/SEPSECS/SEPSECS-ai-review.yaml	SEPSECS	Q9HD40	NCBITaxon:9606	Homo sapiens	18	R-HSA-2408555	Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer	yes	reactome/R-HSA-2408555.md	Sep-tRNA(Sec) is converted to Sec-tRNA(Sec) by PXLP-K284-SEPSECS tetramer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome for the reaction in which the SEPSECS tetramer converts Sep-tRNA(Sec) to Sec-tRNA(Sec). Consistent with the experimentally determined cytoplasmic location.
human	SERINC3	genes/human/SERINC3/SERINC3-ai-review.yaml	SERINC3	Q13530	NCBITaxon:9606	Homo sapiens	15	R-HSA-8932980	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane	yes	reactome/R-HSA-8932980.md	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SERINC3 is a multipass plasma-membrane protein, the location from which it is incorporated into budding retroviral particles.
human	SERINC5	genes/human/SERINC5/SERINC5-ai-review.yaml	SERINC5	Q86VE9	NCBITaxon:9606	Homo sapiens	14	R-HSA-8932980	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane	yes	reactome/R-HSA-8932980.md	SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SERINC5 is a multipass plasma-membrane protein, and the cell surface is the functional location from which it enters budding retroviral envelopes.
human	SERP1	genes/human/SERP1/SERP1-ai-review.yaml	SERP1	Q9Y6X1	NCBITaxon:9606	Homo sapiens	11	R-HSA-1791167	Expression of SERP1 (RAMP4)	yes	reactome/R-HSA-1791167.md	Expression of SERP1 (RAMP4)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SERP1 ER membrane localization (SERP1/RAMP4 expression context).
human	SERP1	genes/human/SERP1/SERP1-ai-review.yaml	SERP1	Q9Y6X1	NCBITaxon:9606	Homo sapiens	12	R-HSA-9609921	SGTA binds Tail-anchored protein	yes	reactome/R-HSA-9609921.md	SGTA binds Tail-anchored protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol annotation arising from a tail-anchored-protein (SGTA) pathway context; SERP1 is an ER membrane protein with a cytosol-facing portion, but cytosol is not its primary compartment.
human	SERPINH1	genes/human/SERPINH1/SERPINH1-ai-review.yaml	SERPINH1	P50454	NCBITaxon:9606	Homo sapiens	18	R-HSA-2022073	Collagen biosynthesis and modifying enzymes	yes	reactome/R-HSA-2022073.md	Procollagen triple helix formation	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) ER lumen localization, matching the precise compartment of HSP47.
human	SERPINH1	genes/human/SERPINH1/SERPINH1-ai-review.yaml	SERPINH1	P50454	NCBITaxon:9606	Homo sapiens	19	R-HSA-2089971	Collagen biosynthesis pathway	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) ER lumen localization, matching the precise compartment of HSP47.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	23	R-HSA-9913332	DAG1(30-653), DAG1(654-895) and SSPN bind SGC	yes	reactome/R-HSA-9913332.md	DAG1(30-653), DAG1(654-895) and SSPN bind SGC	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for Golgi membrane based on Reactome pathway showing sarcoglycan complex assembly and trafficking through Golgi. This represents a transient biosynthetic localization, not the functional localization.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	24	R-HSA-9913336	SGC:DAG1:SSPN complex translocates to plasma membrane	yes	reactome/R-HSA-9913336.md	SGC:DAG1:SSPN complex translocates to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate TAS annotation for Golgi membrane from different Reactome pathway (translocation to plasma membrane). Represents biosynthetic trafficking.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	25	R-HSA-9913338	Sarcoglycan complex (SGC) translocates to the Golgi membrane	yes	reactome/R-HSA-9913338.md	Sarcoglycan complex (SGC) translocates to the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Third duplicate TAS annotation for Golgi from Reactome pathway on sarcoglycan complex translocation. Biosynthetic only.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	26	R-HSA-9913330	SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD	yes	reactome/R-HSA-9913330.md	SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation for ER membrane from Reactome pathway on sarcoglycan complex assembly. Represents biosynthetic/co-translational insertion and folding in ER, not functional localization.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	27	R-HSA-9913338	Sarcoglycan complex (SGC) translocates to the Golgi membrane	yes	reactome/R-HSA-9913338.md	Sarcoglycan complex (SGC) translocates to the Golgi membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate TAS annotation for ER membrane from different Reactome pathway. Biosynthetic localization only.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	28	R-HSA-9913333	DGC complex binds laminins	yes	reactome/R-HSA-9913333.md	DGC complex binds laminins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for plasma membrane from Reactome pathway on DGC binding to laminins. This is the functional localization.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	29	R-HSA-9913336	SGC:DAG1:SSPN complex translocates to plasma membrane	yes	reactome/R-HSA-9913336.md	SGC:DAG1:SSPN complex translocates to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Duplicate TAS for plasma membrane from Reactome translocation pathway.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	30	R-HSA-9913339	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC	yes	reactome/R-HSA-9913339.md	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Third TAS for plasma membrane from Reactome pathway on recruitment of dystrophin complex.
human	SGCA	genes/human/SGCA/SGCA-ai-review.yaml	SGCA	Q16586	NCBITaxon:9606	Homo sapiens	31	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Fourth TAS for plasma membrane from Reactome pathway on DGC binding to agrin and perlecan.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	14	R-HSA-9913332	DAG1(30-653), DAG1(654-895) and SSPN bind SGC	yes	reactome/R-HSA-9913332.md	DAG1(30-653), DAG1(654-895) and SSPN bind SGC	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for DAG1 and SSPN binding to sarcoglycan complex, occurring at Golgi during DGC assembly. Transient localization during biosynthesis.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	15	R-HSA-9913336	SGC:DAG1:SSPN complex translocates to plasma membrane	yes	reactome/R-HSA-9913336.md	SGC:DAG1:SSPN complex translocates to plasma membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sarcoglycan complex translocation to plasma membrane, passing through Golgi. Another trafficking step annotation.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	16	R-HSA-9913338	Sarcoglycan complex (SGC) translocates to the Golgi membrane	yes	reactome/R-HSA-9913338.md	Sarcoglycan complex (SGC) translocates to the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway for sarcoglycan complex translocation to Golgi membrane. Third duplicate of Golgi trafficking annotation.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	17	R-HSA-9913330	SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD	yes	reactome/R-HSA-9913330.md	SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway R-HSA-9913330 for sarcoglycan complex assembly - SGCG/SGCZ and SGCA/SGCE binding to SGCB:SGCD in ER. Initial assembly of sarcoglycan complex occurs in ER membrane before trafficking.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	18	R-HSA-9913338	Sarcoglycan complex (SGC) translocates to the Golgi membrane	yes	reactome/R-HSA-9913338.md	Sarcoglycan complex (SGC) translocates to the Golgi membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Duplicate ER membrane annotation from different Reactome pathway step (sarcoglycan complex translocation to Golgi).
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	19	R-HSA-9913333	DGC complex binds laminins	yes	reactome/R-HSA-9913333.md	DGC complex binds laminins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9913333 - DGC complex binds laminins at plasma membrane. SGCE as part of DGC localizes to plasma membrane where complex interacts with ECM laminins.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	20	R-HSA-9913336	SGC:DAG1:SSPN complex translocates to plasma membrane	yes	reactome/R-HSA-9913336.md	SGC:DAG1:SSPN complex translocates to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9913336 - sarcoglycan:DAG1:SSPN complex translocates to plasma membrane. Final trafficking step where assembled DGC reaches functional site.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	21	R-HSA-9913339	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC	yes	reactome/R-HSA-9913339.md	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9913339 - recruitment of dystrophin, dystrobrevin, syntrophin to DGC at plasma membrane. Assembly of full DGC including cytoplasmic components.
human	SGCE	genes/human/SGCE/SGCE-ai-review.yaml	SGCE	O43556	NCBITaxon:9606	Homo sapiens	22	R-HSA-9914537	DGC complex binds AGRN and HSPG2	yes	reactome/R-HSA-9914537.md	DGC complex binds AGRN and HSPG2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome R-HSA-9914537 - DGC binds agrin and perlecan (HSPG2) at plasma membrane. ECM interactions of assembled DGC.
human	SGMS1	genes/human/SGMS1/SGMS1-ai-review.yaml	SGMS1	Q86VZ5	NCBITaxon:9606	Homo sapiens	16	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Sphingolipid biosynthesis includes the core sphingomyelin-synthesis reaction.
human	SGMS1	genes/human/SGMS1/SGMS1-ai-review.yaml	SGMS1	Q86VZ5	NCBITaxon:9606	Homo sapiens	17	R-HSA-429798	SGMS1 transfers phosphocholine onto ceramide	yes	reactome/R-HSA-429798.md	SGMS1 transfers phosphocholine onto ceramide	Homo sapiens	GO:0033188	sphingomyelin synthase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assignment of sphingomyelin synthase activity, matching the reaction 'SGMS1 transfers phosphocholine onto ceramide'. Correct core function.
human	SGMS1	genes/human/SGMS1/SGMS1-ai-review.yaml	SGMS1	Q86VZ5	NCBITaxon:9606	Homo sapiens	26	R-HSA-429798	SGMS1 transfers phosphocholine onto ceramide	yes	reactome/R-HSA-429798.md	SGMS1 transfers phosphocholine onto ceramide	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) Golgi membrane localization, consistent with the experimentally established site of SGMS1 action.
human	SGMS2	genes/human/SGMS2/SGMS2-ai-review.yaml	SGMS2	Q8NHU3	NCBITaxon:9606	Homo sapiens	18	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Sphingolipid biosynthesis includes the core sphingomyelin-synthesis reaction.
human	SGMS2	genes/human/SGMS2/SGMS2-ai-review.yaml	SGMS2	Q8NHU3	NCBITaxon:9606	Homo sapiens	19	R-HSA-429786	SGMS2 transfers phosphocholine onto ceramide	yes	reactome/R-HSA-429786.md	SGMS2 transfers phosphocholine onto ceramide	Homo sapiens	GO:0033188	sphingomyelin synthase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author-statement for the SGMS2 reaction (transfers phosphocholine onto ceramide), i.e. the core sphingomyelin synthase activity.
human	SGMS2	genes/human/SGMS2/SGMS2-ai-review.yaml	SGMS2	Q8NHU3	NCBITaxon:9606	Homo sapiens	26	R-HSA-429786	SGMS2 transfers phosphocholine onto ceramide	yes	reactome/R-HSA-429786.md	SGMS2 transfers phosphocholine onto ceramide	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement localizing the SGMS2 reaction to the plasma membrane, its primary site.
human	SGPL1	genes/human/SGPL1/SGPL1-ai-review.yaml	SGPL1	O95470	NCBITaxon:9606	Homo sapiens	12	R-HSA-9845614	Sphingolipid catabolism	yes	reactome/R-HSA-9845614.md	Sphingolipid catabolism	Homo sapiens	GO:0030149	sphingolipid catabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing SGPL1 in sphingolipid catabolism. Correct core biological process.
human	SGPL1	genes/human/SGPL1/SGPL1-ai-review.yaml	SGPL1	O95470	NCBITaxon:9606	Homo sapiens	14	R-HSA-428681	PXLP-SGPL1 cleaves sphingoid-1-phosphates	yes	reactome/R-HSA-428681.md	PXLP-SGPL1 cleaves sphingoid-1-phosphates	Homo sapiens	GO:0008117	sphinganine-1-phosphate aldolase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion for the S1P/sphinganine 1-phosphate lyase reaction. Core molecular function, consistent with experimental data.
human	SGPL1	genes/human/SGPL1/SGPL1-ai-review.yaml	SGPL1	O95470	NCBITaxon:9606	Homo sapiens	24	R-HSA-428681	PXLP-SGPL1 cleaves sphingoid-1-phosphates	yes	reactome/R-HSA-428681.md	PXLP-SGPL1 cleaves sphingoid-1-phosphates	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion for ER membrane association. Core location, consistent with experimental evidence.
human	SGPP1	genes/human/SGPP1/SGPP1-ai-review.yaml	SGPP1	Q9BX95	NCBITaxon:9606	Homo sapiens	12	R-HSA-9845614	Sphingolipid catabolism	yes	reactome/R-HSA-9845614.md	Sphingolipid catabolism	Homo sapiens	GO:0030149	sphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway assertion placing SGPP1 in sphingolipid catabolism. As with the ARBA annotation, S1P dephosphorylation is a turnover step but the dominant physiological outcome is recycling into synthesis; retained as non-core.
human	SGPP1	genes/human/SGPP1/SGPP1-ai-review.yaml	SGPP1	Q9BX95	NCBITaxon:9606	Homo sapiens	18	R-HSA-428664	SGPP1,2 dephosphorylate sphingoid-1-phosphates	yes	reactome/R-HSA-428664.md	SGPP1,2 dephosphorylate sphingoid-1-phosphates	Homo sapiens	GO:0042392	sphingosine-1-phosphate phosphatase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author-statement for the S1P phosphatase reaction (SGPP1,2 dephosphorylate sphingoid-1-phosphates). Correct and consistent with the experimental annotations to the same core activity.
human	SGPP1	genes/human/SGPP1/SGPP1-ai-review.yaml	SGPP1	Q9BX95	NCBITaxon:9606	Homo sapiens	23	R-HSA-428664	SGPP1,2 dephosphorylate sphingoid-1-phosphates	yes	reactome/R-HSA-428664.md	SGPP1,2 dephosphorylate sphingoid-1-phosphates	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the SGPP1 dephosphorylation reaction at the ER membrane. Consistent with the experimental localization; correct.
human	SGPP2	genes/human/SGPP2/SGPP2-ai-review.yaml	SGPP2	Q8IWX5	NCBITaxon:9606	Homo sapiens	10	R-HSA-9845614	Sphingolipid catabolism	yes	reactome/R-HSA-9845614.md	Sphingolipid catabolism	Homo sapiens	GO:0030149	sphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome traceable-author annotation placing SGPP2 in sphingolipid catabolism. Consistent with the ARBA IEA annotation to the same process term.
human	SGPP2	genes/human/SGPP2/SGPP2-ai-review.yaml	SGPP2	Q8IWX5	NCBITaxon:9606	Homo sapiens	14	R-HSA-428664	SGPP1,2 dephosphorylate sphingoid-1-phosphates	yes	reactome/R-HSA-428664.md	SGPP1,2 dephosphorylate sphingoid-1-phosphates	Homo sapiens	GO:0042392	sphingosine-1-phosphate phosphatase activity	TAS	enables	MF	false		ACCEPT	Reactome traceable-author annotation to the core sphingosine-1-phosphate phosphatase activity, modeling SGPP1/2 dephosphorylation of cytosolic S1P, dihydro-S1P and phyto-S1P at the ER membrane.
human	SGPP2	genes/human/SGPP2/SGPP2-ai-review.yaml	SGPP2	Q8IWX5	NCBITaxon:9606	Homo sapiens	17	R-HSA-428664	SGPP1,2 dephosphorylate sphingoid-1-phosphates	yes	reactome/R-HSA-428664.md	SGPP1,2 dephosphorylate sphingoid-1-phosphates	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author localization of SGPP2 to the ER membrane, where it dephosphorylates cytosolic sphingoid-base 1-phosphates. Consistent with the experimental IDA and phylogenetic IBA localizations.
human	SGSH	genes/human/SGSH/SGSH-ai-review.yaml	SGSH	P51688	NCBITaxon:9606	Homo sapiens	11	R-HSA-2263444	Defective SGSH does not hydrolyse Heparan sulfate chain(7)	yes	reactome/R-HSA-2263444.md	Defective SGSH does not hydrolyse Heparan sulfate chain(7)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal lumen localisation for the mature SGSH enzyme.
human	SGSH	genes/human/SGSH/SGSH-ai-review.yaml	SGSH	P51688	NCBITaxon:9606	Homo sapiens	12	R-HSA-9036050	Defective SGSH does not hydrolyse Heparan sulfate chain(2)	yes	reactome/R-HSA-9036050.md	Defective SGSH does not hydrolyse Heparan sulfate chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal lumen localisation (duplicate assertion from a distinct Reactome reaction).
human	SGSH	genes/human/SGSH/SGSH-ai-review.yaml	SGSH	P51688	NCBITaxon:9606	Homo sapiens	20	R-HSA-1678708	SGSH hydrolyses Heparan sulfate chain(2)	yes	reactome/R-HSA-1678708.md	SGSH hydrolyses Heparan sulfate chain(2)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal lumen localisation (from the HS-GAG degradation pathway).
human	SGSH	genes/human/SGSH/SGSH-ai-review.yaml	SGSH	P51688	NCBITaxon:9606	Homo sapiens	21	R-HSA-2090043	SGSH hydrolyses Heparan sulfate chain(7)	yes	reactome/R-HSA-2090043.md	SGSH hydrolyses Heparan sulfate chain(7)	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	Reactome-asserted lysosomal lumen localisation (duplicate assertion from a distinct Reactome reaction).
human	SGTA	genes/human/SGTA/SGTA-ai-review.yaml	SGTA	O43765	NCBITaxon:9606	Homo sapiens	37	R-HSA-9609921	Cytosolic quality control / TA-protein targeting pathway	yes	reactome/R-HSA-9609921.md	SGTA binds Tail-anchored protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with SGTA's principal compartment.
human	SGTA	genes/human/SGTA/SGTA-ai-review.yaml	SGTA	O43765	NCBITaxon:9606	Homo sapiens	38	R-HSA-9617595	Cytosolic quality control / TA-protein targeting pathway	yes	reactome/R-HSA-9617595.md	SGTA binds mislocalized membrane protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with SGTA's principal compartment.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	84	R-HSA-5358460	HPE SHH variants don't undergo autoproteolytic cleavage	yes	reactome/R-HSA-5358460.md	HPE SHH variants don't undergo autoproteolytic cleavage	Homo sapiens	GO:0004175	endopeptidase activity	TAS	enables	MF	false		MODIFY	SHH cleavage is coupled to cholesterol transfer; the precise current activity term is cholesterol-protein transferase activity. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5358460.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	90	R-HSA-5387389	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	yes	reactome/R-HSA-5387389.md	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5387389.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	91	R-HSA-5483238	Hh processing variants are ubiquitinated	yes	reactome/R-HSA-5483238.md	Hh processing variants are ubiquitinated	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5483238.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	92	R-HSA-5387389	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	yes	reactome/R-HSA-5387389.md	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome localization concerns transient retrotranslocated C-terminal or processing-defective fragments destined for degradation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5387389.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	93	R-HSA-5387392	processing defective Hh variants are degraded by the proteasome	yes	reactome/R-HSA-5387392.md	processing defective Hh variants are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome localization concerns transient retrotranslocated C-terminal or processing-defective fragments destined for degradation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5387392.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	95	R-HSA-445448	HHIP binds Hedgehog	yes	reactome/R-HSA-445448.md	HHIP binds Hedgehog	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed signaling product SHH-N is released into the extracellular region and acts there as a morphogen. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-445448.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	96	R-HSA-5632649	Hh-Npp binds GAS1 and PTCH	yes	reactome/R-HSA-5632649.md	Hh-Npp binds GAS1 and PTCH	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed signaling product SHH-N is released into the extracellular region and acts there as a morphogen. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5632649.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	97	R-HSA-5632652	Hh-Npp binds CDON and PTCH	yes	reactome/R-HSA-5632652.md	Hh-Npp binds CDON and PTCH	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed signaling product SHH-N is released into the extracellular region and acts there as a morphogen. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5632652.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	98	R-HSA-5358336	P4HB forms mixed disulphides with Hh precursors	yes	reactome/R-HSA-5358336.md	P4HB forms mixed disulphides with Hh precursors	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5358336.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	99	R-HSA-5358340	Autoproteolytic cleavage of Hh precursors	yes	reactome/R-HSA-5358340.md	Autoproteolytic cleavage of Hh precursors	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5358340.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	100	R-HSA-5358343	HHAT palmitoylates Hh N-terminal fragment	yes	reactome/R-HSA-5358343.md	HHAT palmitoylates Hh N-terminal fragment	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5358343.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	101	R-HSA-5362386	Glycosylation of Hh	yes	reactome/R-HSA-5362386.md	Glycosylation of Hh	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362386.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	102	R-HSA-5362412	SYVN1 ubiquitinates Hh C-terminal fragments	yes	reactome/R-HSA-5362412.md	SYVN1 ubiquitinates Hh C-terminal fragments	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362412.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	103	R-HSA-5362437	C-terminal Hh fragments are bound by lectins	yes	reactome/R-HSA-5362437.md	C-terminal Hh fragments are bound by lectins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362437.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	104	R-HSA-5362441	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	yes	reactome/R-HSA-5362441.md	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362441.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	105	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	yes	reactome/R-HSA-5362459.md	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362459.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	106	R-HSA-5362549	Hh-Np traffics to the plasma membrane	yes	reactome/R-HSA-5362549.md	Hh-Np traffics to the plasma membrane	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362549.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	107	R-HSA-5362448	Hh C-terminal fragments are degraded by the proteasome	yes	reactome/R-HSA-5362448.md	Hh C-terminal fragments are degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome localization concerns transient retrotranslocated C-terminal or processing-defective fragments destined for degradation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362448.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	108	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	yes	reactome/R-HSA-5362459.md	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome localization concerns transient retrotranslocated C-terminal or processing-defective fragments destined for degradation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362459.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	109	R-HSA-5362427	Hh-Np binds GPC5	yes	reactome/R-HSA-5362427.md	Hh-Np binds GPC5	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Dually lipidated SHH-N is tethered at the producing-cell plasma membrane before carrier-mediated release. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362427.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	110	R-HSA-5362549	Hh-Np traffics to the plasma membrane	yes	reactome/R-HSA-5362549.md	Hh-Np traffics to the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Dually lipidated SHH-N is tethered at the producing-cell plasma membrane before carrier-mediated release. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362549.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	111	R-HSA-5362551	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling	yes	reactome/R-HSA-5362551.md	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Dually lipidated SHH-N is tethered at the producing-cell plasma membrane before carrier-mediated release. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362551.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	112	R-HSA-5362553	NOTUM releases Hh-Np:GPC5 from the plasma membrane	yes	reactome/R-HSA-5362553.md	NOTUM releases Hh-Np:GPC5 from the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Dually lipidated SHH-N is tethered at the producing-cell plasma membrane before carrier-mediated release. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362553.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	113	R-NUL-5362406	mouse Disp2 binds SHH N-terminal fragment	yes	reactome/R-NUL-5362406.md	mouse Disp2 binds SHH N-terminal fragment	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Dually lipidated SHH-N is tethered at the producing-cell plasma membrane before carrier-mediated release. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-NUL-5362406.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	117	R-HSA-5358460	HPE SHH variants don't undergo autoproteolytic cleavage	yes	reactome/R-HSA-5358460.md	HPE SHH variants don't undergo autoproteolytic cleavage	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5358460.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	118	R-HSA-5362450	Hh processing variants bind lectins	yes	reactome/R-HSA-5362450.md	Hh processing variants bind lectins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362450.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	119	R-HSA-5387386	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	yes	reactome/R-HSA-5387386.md	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5387386.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	120	R-HSA-5483229	HHAT G287V doesn't palmitoylate Hh-Np	yes	reactome/R-HSA-5483229.md	HHAT G287V doesn't palmitoylate Hh-Np	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The SHH precursor and processing intermediates occupy the ER lumen during maturation. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5483229.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	122	R-HSA-5362551	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling	yes	reactome/R-HSA-5362551.md	Hh-Np binds SCUBE2 in the extracellular region to promote long-range signalling	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed signaling product SHH-N is released into the extracellular region and acts there as a morphogen. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362551.
human	SHH	genes/human/SHH/SHH-ai-review.yaml	SHH	Q15465	NCBITaxon:9606	Homo sapiens	123	R-HSA-5362553	NOTUM releases Hh-Np:GPC5 from the plasma membrane	yes	reactome/R-HSA-5362553.md	NOTUM releases Hh-Np:GPC5 from the plasma membrane	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed signaling product SHH-N is released into the extracellular region and acts there as a morphogen. This GOA record uses traceable-author-statement evidence (TAS) from Reactome:R-HSA-5362553.
human	SHMT1	genes/human/SHMT1/SHMT1-ai-review.yaml	SHMT1	P34896	NCBITaxon:9606	Homo sapiens	30	R-HSA-71262	Carnitine synthesis	yes	reactome/R-HSA-71262.md	Carnitine synthesis	Homo sapiens	GO:0045329	carnitine biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (Carnitine synthesis) TAS annotation, consistent with SHMT1's HTMLA backup role in carnitine biosynthesis. Non-core.
human	SHMT1	genes/human/SHMT1/SHMT1-ai-review.yaml	SHMT1	P34896	NCBITaxon:9606	Homo sapiens	31	R-HSA-196757	Metabolism of folate and pterines	yes	reactome/R-HSA-196757.md	Metabolism of folate and pterines	Homo sapiens	GO:0046655	folic acid metabolic process	TAS	involved_in	BP	false		ACCEPT	Reactome (Metabolism of folate and pterines) TAS annotation. SHMT1 participates in folate metabolism; this is a broad parent of the more specific THF interconversion term but a correct pathway context.
human	SHMT1	genes/human/SHMT1/SHMT1-ai-review.yaml	SHMT1	P34896	NCBITaxon:9606	Homo sapiens	79	R-HSA-200651	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine	yes	reactome/R-HSA-200651.md	5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (5,10-methylene-THF + glycine <=> THF + serine reaction). Core primary localization.
human	SHMT1	genes/human/SHMT1/SHMT1-ai-review.yaml	SHMT1	P34896	NCBITaxon:9606	Homo sapiens	80	R-HSA-200735	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG	yes	reactome/R-HSA-200735.md	SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (SHMT1 tetramer transfers hydroxymethyl to THFPG). Core primary localization.
human	SHMT1	genes/human/SHMT1/SHMT1-ai-review.yaml	SHMT1	P34896	NCBITaxon:9606	Homo sapiens	81	R-HSA-71249	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly	yes	reactome/R-HSA-71249.md	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS cytosol localization (SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly, the carnitine-pathway step). Core primary localization.
human	SHMT2	genes/human/SHMT2/SHMT2-ai-review.yaml	SHMT2	P34897	NCBITaxon:9606	Homo sapiens	46	R-HSA-5694137	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser	yes	reactome/R-HSA-5694137.md	PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome places the SHMT2 catalytic reaction at the mitochondrial inner membrane. SHMT2 is principally a matrix enzyme that associates with the inner membrane; keep this inner-membrane localization as non-core.
human	SHMT2	genes/human/SHMT2/SHMT2-ai-review.yaml	SHMT2	P34897	NCBITaxon:9606	Homo sapiens	47	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	From a Reactome LONP1 substrate-binding reaction (SHMT2 as an inner-membrane-associated protein degraded by LONP1). Inner-membrane association is real but non-core relative to the matrix.
human	SHMT2	genes/human/SHMT2/SHMT2-ai-review.yaml	SHMT2	P34897	NCBITaxon:9606	Homo sapiens	48	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	From a Reactome LONP1 substrate-degradation reaction; inner-membrane association, non-core.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	34	R-HSA-5660753	SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA	yes	reactome/R-HSA-5660753.md	SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Reactome curation (SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA) of ubiquitin-protein transferase activity, the core catalytic molecular function.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	35	R-HSA-5667107	SIAH1, SIAH2 ubiquitinate SNCAIP	yes	reactome/R-HSA-5667107.md	SIAH1, SIAH2 ubiquitinate SNCAIP	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Reactome curation (SIAH1, SIAH2 ubiquitinate SNCAIP) of ubiquitin-protein transferase activity, the core catalytic molecular function.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	36	R-HSA-977225	Amyloid fiber formation	yes	reactome/R-HSA-977225.md	Amyloid fiber formation	Homo sapiens	GO:1990000	amyloid fibril formation	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome curation placing SIAH1 in the amyloid-fiber-formation pathway via its alpha-synuclein context. This is the substrate's aggregation behavior, not an intrinsic SIAH1 function.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	47	R-HSA-374665	DCC interaction with SIAH1	yes	reactome/R-HSA-374665.md	DCC interaction with SIAH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (DCC interaction with SIAH1). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	48	R-HSA-5658092	SIAH1, SIAH2 bind SNCAIP	yes	reactome/R-HSA-5658092.md	SIAH1, SIAH2 bind SNCAIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (SIAH1, SIAH2 bind SNCAIP). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	49	R-HSA-5658496	SIAH1:UBE2L6:Ubiquitin binds SNCA	yes	reactome/R-HSA-5658496.md	SIAH1:UBE2L6:Ubiquitin binds SNCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (SIAH1:UBE2L6:Ubiquitin binds SNCA). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	50	R-HSA-5660753	SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA	yes	reactome/R-HSA-5660753.md	SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	51	R-HSA-5660757	Ub-SNCA dissociates from the conjugating enzyme	yes	reactome/R-HSA-5660757.md	Ub-SNCA dissociates from the conjugating enzyme	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (Ub-SNCA dissociates from the conjugating enzyme). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	52	R-HSA-5667107	SIAH1, SIAH2 ubiquitinate SNCAIP	yes	reactome/R-HSA-5667107.md	SIAH1, SIAH2 ubiquitinate SNCAIP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (SIAH1, SIAH2 ubiquitinate SNCAIP). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	53	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (generic transfer of Ub from E2 to substrate). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	54	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	55	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (polyubiquitination of substrate). Consistent with the core cytoplasmic site of action.
human	SIAH1	genes/human/SIAH1/SIAH1-ai-review.yaml	SIAH1	Q8IUQ4	NCBITaxon:9606	Homo sapiens	56	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub complex). Consistent with the core cytoplasmic site of action.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	159	R-HSA-427359	SIRT1 negatively regulates rRNA expression	yes	reactome/R-HSA-427359.md	SIRT1 negatively regulates rRNA expression	Homo sapiens	GO:0000183	rDNA heterochromatin formation	TAS	involved_in	BP	false		ACCEPT	SIRT1 in eNoSC promotes rRNA gene silencing via histone modification.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	160	R-HSA-3371453	Regulation of HSF1-mediated heat shock response	yes	reactome/R-HSA-3371453.md	Regulation of HSF1-mediated heat shock response	Homo sapiens	GO:1900034	regulation of cellular response to heat	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SIRT1 participates in heat shock response regulation via HSF1 deacetylation.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	161	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0034979	NAD-dependent protein lysine deacetylase activity	TAS	enables	MF	false		ACCEPT	SIRT1 functions as a NAD-dependent deacetylase in the HSF1 heat shock pathway.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	162	R-HSA-9620532	SIRT1,SIRT3 deacetylate FOXO3	yes	reactome/R-HSA-9620532.md	SIRT1,SIRT3 deacetylate FOXO3	Homo sapiens	GO:0034979	NAD-dependent protein lysine deacetylase activity	TAS	enables	MF	false		ACCEPT	SIRT1 deacetylates FOXO3 as an NAD-dependent histone deacetylase.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	174	R-HSA-9825772	SIRT1 deacetylates HINT1 dimer	yes	reactome/R-HSA-9825772.md	SIRT1 deacetylates HINT1 dimer	Homo sapiens	GO:0033558	protein lysine deacetylase activity	TAS	enables	MF	false		ACCEPT	SIRT1 deacetylates HINT1, consistent with protein lysine deacetylase activity.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	265	R-HSA-3371467	SIRT1 deacetylates HSF1	yes	reactome/R-HSA-3371467.md	SIRT1 deacetylates HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in contexts including HSF1 regulation.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	266	R-HSA-3371518	SIRT1 binds to HSF1	yes	reactome/R-HSA-3371518.md	SIRT1 binds to HSF1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in HSF1 regulatory contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	267	R-HSA-3371537	DBC1 binds SIRT1	yes	reactome/R-HSA-3371537.md	DBC1 binds SIRT1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in DBC1 regulatory contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	268	R-HSA-427514	eNoSC deacetylates histone H3	yes	reactome/R-HSA-427514.md	eNoSC deacetylates histone H3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in eNoSC chromatin regulation contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	269	R-HSA-427527	eNoSC dimethylates histone H3 at lysine-9	yes	reactome/R-HSA-427527.md	eNoSC dimethylates histone H3 at lysine-9	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in eNoSC chromatin regulation contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	270	R-HSA-427528	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)	yes	reactome/R-HSA-427528.md	Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in eNoSC complex contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	271	R-HSA-9620532	SIRT1,SIRT3 deacetylate FOXO3	yes	reactome/R-HSA-9620532.md	SIRT1,SIRT3 deacetylate FOXO3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in FOXO3 regulation contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	272	R-HSA-9765850	ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter	yes	reactome/R-HSA-9765850.md	ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in transcriptional regulation contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	273	R-HSA-9825772	SIRT1 deacetylates HINT1 dimer	yes	reactome/R-HSA-9825772.md	SIRT1 deacetylates HINT1 dimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in HINT1-related regulatory contexts.
human	SIRT1	genes/human/SIRT1/SIRT1-ai-review.yaml	SIRT1	Q96EB6	NCBITaxon:9606	Homo sapiens	274	R-HSA-9854916	MITF-M-dependent SIRT1 gene expression	yes	reactome/R-HSA-9854916.md	MITF-M-dependent SIRT1 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	SIRT1 is nuclear in transcriptional regulation contexts.
human	SIRT2	genes/human/SIRT2/SIRT2-ai-review.yaml	SIRT2	Q8IXJ6	NCBITaxon:9606	Homo sapiens	85	R-HSA-2995410	Reactome pathway: Mitotic nuclear membrane reassembly	yes	reactome/R-HSA-2995410.md	Nuclear Envelope (NE) Reassembly	Homo sapiens	GO:0007084	mitotic nuclear membrane reassembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SIRT2 involved in nuclear envelope reassembly pathway via ANKLE2 deacetylation.
human	SIRT2	genes/human/SIRT2/SIRT2-ai-review.yaml	SIRT2	Q8IXJ6	NCBITaxon:9606	Homo sapiens	86	R-HSA-9667952	Reactome pathway: SIRT2 deacetylates ANKLE2	yes	reactome/R-HSA-9667952.md	ANKLE2 is deacetylated by SIRT2	Homo sapiens	GO:0034979	NAD-dependent protein lysine deacetylase activity	TAS	enables	MF	false		ACCEPT	SIRT2 deacetylates ANKLE2 in Reactome pathway.
human	SIRT2	genes/human/SIRT2/SIRT2-ai-review.yaml	SIRT2	Q8IXJ6	NCBITaxon:9606	Homo sapiens	102	R-HSA-9667952	Reactome pathway: SIRT2 deacetylates ANKLE2	yes	reactome/R-HSA-9667952.md	ANKLE2 is deacetylated by SIRT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic SIRT2 in Reactome pathway.
human	SIRT5	genes/human/SIRT5/SIRT5-ai-review.yaml	SIRT5	Q9NXA8	NCBITaxon:9606	Homo sapiens	1	R-HSA-70635	Urea cycle	yes	reactome/R-HSA-70635.md	Urea cycle	Homo sapiens	GO:0000050	urea cycle	TAS	involved_in	BP	false		ACCEPT	SIRT5 deacylates CPS1 and thereby regulates urea-cycle capacity; participation does not imply it catalyzes a urea-cycle small-molecule reaction.
human	SIRT5	genes/human/SIRT5/SIRT5-ai-review.yaml	SIRT5	Q9NXA8	NCBITaxon:9606	Homo sapiens	20	R-HSA-5688294	SIRT5 deacetylates Cytochrome C	yes	reactome/R-HSA-5688294.md	SIRT5 deacetylates Cytochrome C	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	SIRT5 acts on mitochondrial matrix metabolic substrates, including CPS1 and SHMT2.
human	SIRT5	genes/human/SIRT5/SIRT5-ai-review.yaml	SIRT5	Q9NXA8	NCBITaxon:9606	Homo sapiens	21	R-HSA-9955504	SIRT5 deglutarylates CPS1	yes	reactome/R-HSA-9955504.md	SIRT5 deglutarylates CPS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	SIRT5 acts on mitochondrial matrix metabolic substrates, including CPS1 and SHMT2.
human	SIRT5	genes/human/SIRT5/SIRT5-ai-review.yaml	SIRT5	Q9NXA8	NCBITaxon:9606	Homo sapiens	28	R-HSA-1592230	Mitochondrial biogenesis	yes	reactome/R-HSA-1592230.md	Mitochondrial biogenesis	Homo sapiens	GO:0007005	mitochondrion organization	TAS	involved_in	BP	false		ACCEPT	Regulation of mitochondrial substrates and metabolism connects SIRT5 deacylation to mitochondrial organization and maintenance.
human	SIRT5	genes/human/SIRT5/SIRT5-ai-review.yaml	SIRT5	Q9NXA8	NCBITaxon:9606	Homo sapiens	38	R-HSA-5688294	SIRT5 deacetylates Cytochrome C	yes	reactome/R-HSA-5688294.md	SIRT5 deacetylates Cytochrome C	Homo sapiens	GO:0034979	NAD-dependent protein lysine deacetylase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Purified human SIRT5 has weak NAD-dependent deacetylation, substantially less efficient than its acidic deacylation activities.
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	276	R-HSA-1363328	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-1363328.md	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	277	R-HSA-1363331	Ubiquitination of p130 (RBL2) by SCF (Skp2)	yes	reactome/R-HSA-1363331.md	Ubiquitination of p130 (RBL2) by SCF (Skp2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of p130 (RBL2) by SCF (Skp2)""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	278	R-HSA-187545	Association of Cks1 with SCF(Skp2) complex	yes	reactome/R-HSA-187545.md	Association of Cks1 with SCF(Skp2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Association of Cks1 with SCF(Skp2) complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	279	R-HSA-187552	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	280	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Degradation of ubiquitinated p27/p21 by the 26S proteasome""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	281	R-HSA-187575	Ubiquitination of phospho-p27/p21	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of phospho-p27/p21""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	282	R-HSA-2220967	p-NICD1 PEST domain mutants do not bind FBXW7	yes	reactome/R-HSA-2220967.md	p-NICD1 PEST domain mutants do not bind FBXW7	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""p-NICD1 PEST domain mutants do not bind FBXW7""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	283	R-HSA-2220978	FBXW7 WD mutants do not bind NICD1	yes	reactome/R-HSA-2220978.md	FBXW7 WD mutants do not bind NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""FBXW7 WD mutants do not bind NICD1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	284	R-HSA-68946	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	yes	reactome/R-HSA-68946.md	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Phosphorylated Orc1 is ubiquitinated while still associated with chromatin""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	285	R-HSA-69598	Ubiquitination of phosphorylated CDC25A	yes	reactome/R-HSA-69598.md	Ubiquitination of phosphorylated CDC25A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of phosphorylated CDC25A""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	286	R-HSA-8939688	SCF(SKP2) complex binds RUNX2	yes	reactome/R-HSA-8939688.md	SCF(SKP2) complex binds RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF(SKP2) complex binds RUNX2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	287	R-HSA-8939706	SCF(SKP2) polyubiquitinates RUNX2	yes	reactome/R-HSA-8939706.md	SCF(SKP2) polyubiquitinates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF(SKP2) polyubiquitinates RUNX2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	288	R-HSA-9708517	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	yes	reactome/R-HSA-9708517.md	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	289	R-HSA-9708525	BACH1:FBXL17 binds SCF(SKP2) complex	yes	reactome/R-HSA-9708525.md	BACH1:FBXL17 binds SCF(SKP2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""BACH1:FBXL17 binds SCF(SKP2) complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	290	R-HSA-9725023	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	yes	reactome/R-HSA-9725023.md	NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	291	R-HSA-9725030	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	yes	reactome/R-HSA-9725030.md	MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	292	R-HSA-9762091	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	yes	reactome/R-HSA-9762091.md	NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	293	R-HSA-9762093	BTRC binds p-S344, 347 NFE2L2	yes	reactome/R-HSA-9762093.md	BTRC binds p-S344, 347 NFE2L2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""BTRC binds p-S344, 347 NFE2L2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	294	R-HSA-9762096	Ub,pS335,S338,T NFE2L2 is degraded	yes	reactome/R-HSA-9762096.md	Ub,pS335,S338,T NFE2L2 is degraded	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ub,pS335,S338,T NFE2L2 is degraded""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	295	R-NUL-2064853	FBXW7 binds phosphorylated NICD1	yes	reactome/R-NUL-2064853.md	FBXW7 binds phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""FBXW7 binds phosphorylated NICD1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	296	R-NUL-2064883	FBXW7 mediates ubiquitination of phosphorylated NICD1	yes	reactome/R-NUL-2064883.md	FBXW7 mediates ubiquitination of phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""FBXW7 mediates ubiquitination of phosphorylated NICD1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	297	R-NUL-9604628	FBXW7 promotes ubiquitination of mouse p-NICD4	yes	reactome/R-NUL-9604628.md	FBXW7 promotes ubiquitination of mouse p-NICD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""FBXW7 promotes ubiquitination of mouse p-NICD4""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	305	R-HSA-1168642	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB	yes	reactome/R-HSA-1168642.md	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	306	R-HSA-1168643	SCF-beta-TrCP ubiquitinylates IkB	yes	reactome/R-HSA-1168643.md	SCF-beta-TrCP ubiquitinylates IkB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-beta-TrCP ubiquitinylates IkB""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	307	R-HSA-1170539	Prolactin receptor is internalized	yes	reactome/R-HSA-1170539.md	Prolactin receptor is internalized	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Prolactin receptor is internalized""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	308	R-HSA-1370500	PRLR binds SCF beta-TrCP complex	yes	reactome/R-HSA-1370500.md	PRLR binds SCF beta-TrCP complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""PRLR binds SCF beta-TrCP complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	309	R-HSA-174159	Ubiquitination of Emi1 by SCF-beta-TrCP	yes	reactome/R-HSA-174159.md	Ubiquitination of Emi1 by SCF-beta-TrCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of Emi1 by SCF-beta-TrCP""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	310	R-HSA-174203	SCF-mediated degradation of Emi1	yes	reactome/R-HSA-174203.md	SCF-mediated degradation of Emi1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-mediated degradation of Emi1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	311	R-HSA-174209	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	yes	reactome/R-HSA-174209.md	Phosphorylated Emi1 binds the beta-TrCP in the SCF complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Phosphorylated Emi1 binds the beta-TrCP in the SCF complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	312	R-HSA-180573	Degradation of ubiquitinated CD4	yes	reactome/R-HSA-180573.md	Degradation of ubiquitinated CD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Degradation of ubiquitinated CD4""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	313	R-HSA-180597	Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex	yes	reactome/R-HSA-180597.md	Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	314	R-HSA-180599	The Vpu:CD4:beta-TrCP complex recruits SKP1	yes	reactome/R-HSA-180599.md	The Vpu:CD4:beta-TrCP complex recruits SKP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""The Vpu:CD4:beta-TrCP complex recruits SKP1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	315	R-HSA-209063	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	yes	reactome/R-HSA-209063.md	Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	316	R-HSA-209125	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	yes	reactome/R-HSA-209125.md	SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""'SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex'""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	317	R-HSA-2130279	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	yes	reactome/R-HSA-2130279.md	Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	318	R-HSA-2130282	Degradation of ubiquitinated beta catenin by the proteasome	yes	reactome/R-HSA-2130282.md	Degradation of ubiquitinated beta catenin by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Degradation of ubiquitinated beta catenin by the proteasome""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	319	R-HSA-2130286	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	yes	reactome/R-HSA-2130286.md	Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	320	R-HSA-3000335	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA	yes	reactome/R-HSA-3000335.md	SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	321	R-HSA-3000339	Phosphorylated BORA binds SCF-beta-TrCp1/2	yes	reactome/R-HSA-3000339.md	Phosphorylated BORA binds SCF-beta-TrCp1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Phosphorylated BORA binds SCF-beta-TrCp1/2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	322	R-HSA-5607723	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB	yes	reactome/R-HSA-5607723.md	SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	323	R-HSA-5607725	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP	yes	reactome/R-HSA-5607725.md	SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	324	R-HSA-5607728	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex	yes	reactome/R-HSA-5607728.md	beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	325	R-HSA-5610742	SCF(beta-TrCP) ubiquitinates p-GLI1	yes	reactome/R-HSA-5610742.md	SCF(beta-TrCP) ubiquitinates p-GLI1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF(beta-TrCP) ubiquitinates p-GLI1""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	326	R-HSA-5610746	SCF(beta-TrCP) ubiquitinates p-GLI3	yes	reactome/R-HSA-5610746.md	SCF(beta-TrCP) ubiquitinates p-GLI3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF(beta-TrCP) ubiquitinates p-GLI3""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	327	R-HSA-5684248	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2	yes	reactome/R-HSA-5684248.md	SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	328	R-HSA-5684250	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2	yes	reactome/R-HSA-5684250.md	SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""'SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 '""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	329	R-HSA-5691108	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	yes	reactome/R-HSA-5691108.md	SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	330	R-HSA-5691167	CUL1, SKP1, FBXL5 bind	yes	reactome/R-HSA-5691167.md	CUL1, SKP1, FBXL5 bind	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""CUL1, SKP1, FBXL5 bind""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	331	R-HSA-5691176	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	yes	reactome/R-HSA-5691176.md	NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	332	R-HSA-8853496	SCF:FBXL7 binds AURKA	yes	reactome/R-HSA-8853496.md	SCF:FBXL7 binds AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF:FBXL7 binds AURKA""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	333	R-HSA-8854041	SCF-FBXL7 ubiquitinates AURKA	yes	reactome/R-HSA-8854041.md	SCF-FBXL7 ubiquitinates AURKA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-FBXL7 ubiquitinates AURKA""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	334	R-HSA-8854044	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	yes	reactome/R-HSA-8854044.md	Proteasome degrades AURKA ubiquitinated by SCF-FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Proteasome degrades AURKA ubiquitinated by SCF-FBXL7""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	335	R-HSA-8854051	SCF-FBXL18 ubiquitinates FBXL7	yes	reactome/R-HSA-8854051.md	SCF-FBXL18 ubiquitinates FBXL7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""SCF-FBXL18 ubiquitinates FBXL7""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	336	R-HSA-8854052	Formation of the SCF-FBXL7 complex	yes	reactome/R-HSA-8854052.md	Formation of the SCF-FBXL7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Formation of the SCF-FBXL7 complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	337	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	338	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	339	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""CAND1 binds cytosolic CRL E3 ubiquitin ligases""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	340	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	341	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	342	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	343	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Transfer of Ub from E2 to substrate and release of E2""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	344	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Release of E3 from polyubiquitinated substrate""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	345	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Polyubiquitination of substrate""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	346	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Interaction of E3 with substrate and E2-Ub complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	347	R-HSA-9929350	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	yes	reactome/R-HSA-9929350.md	Ubiquitination of CD274 by BTRC-SCF E3-ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitination of CD274 by BTRC-SCF E3-ligase complex""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	348	R-HSA-9929352	Ubiquitinated CD274 is degraded by the 26S proteasome	yes	reactome/R-HSA-9929352.md	Ubiquitinated CD274 is degraded by the 26S proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Ubiquitinated CD274 is degraded by the 26S proteasome""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	349	R-HSA-9929353	Deubiquitination of CD274	yes	reactome/R-HSA-9929353.md	Deubiquitination of CD274	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""Deubiquitination of CD274""."
human	SKP1	genes/human/SKP1/SKP1-ai-review.yaml	SKP1	P63208	NCBITaxon:9606	Homo sapiens	350	R-HSA-9929357	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	yes	reactome/R-HSA-9929357.md	p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic SKP1 as a subunit of the SCF ligase in the Reactome reaction ""p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	57	R-HSA-1363328	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-1363328.md	Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	58	R-HSA-1363331	Ubiquitination of p130 (RBL2) by SCF (Skp2)	yes	reactome/R-HSA-1363331.md	Ubiquitination of p130 (RBL2) by SCF (Skp2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Ubiquitination of p130 (RBL2) by SCF (Skp2)""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	59	R-HSA-187545	Association of Cks1 with SCF(Skp2) complex	yes	reactome/R-HSA-187545.md	Association of Cks1 with SCF(Skp2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Association of Cks1 with SCF(Skp2) complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	60	R-HSA-187552	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	yes	reactome/R-HSA-187552.md	Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	61	R-HSA-187574	Degradation of ubiquitinated p27/p21 by the 26S proteasome	yes	reactome/R-HSA-187574.md	Degradation of ubiquitinated p27/p21 by the 26S proteasome	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Degradation of ubiquitinated p27/p21 by the 26S proteasome""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	62	R-HSA-187575	Ubiquitination of phospho-p27/p21	yes	reactome/R-HSA-187575.md	Ubiquitination of phospho-p27/p21	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Ubiquitination of phospho-p27/p21""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	63	R-HSA-188191	APC/C:Cdh1-mediated degradation of Skp2	yes	reactome/R-HSA-188191.md	APC/C:Cdh1-mediated degradation of Skp2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""APC/C:Cdh1-mediated degradation of Skp2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	64	R-HSA-6781922	USP13 binds UFD1L:SKP2	yes	reactome/R-HSA-6781922.md	USP13 binds UFD1L:SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""USP13 binds UFD1L:SKP2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	65	R-HSA-68946	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	yes	reactome/R-HSA-68946.md	Phosphorylated Orc1 is ubiquitinated while still associated with chromatin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Phosphorylated Orc1 is ubiquitinated while still associated with chromatin""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	66	R-HSA-8939688	SCF(SKP2) complex binds RUNX2	yes	reactome/R-HSA-8939688.md	SCF(SKP2) complex binds RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""SCF(SKP2) complex binds RUNX2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	67	R-HSA-8939706	SCF(SKP2) polyubiquitinates RUNX2	yes	reactome/R-HSA-8939706.md	SCF(SKP2) polyubiquitinates RUNX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""SCF(SKP2) polyubiquitinates RUNX2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	68	R-HSA-9686969	APC/C:Cdh1 polyubiquitinates SKP2	yes	reactome/R-HSA-9686969.md	APC/C:Cdh1 polyubiquitinates SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""APC/C:Cdh1 polyubiquitinates SKP2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	69	R-HSA-9686980	RB1 recruits APC/C:Cdh1 complex to SKP2	yes	reactome/R-HSA-9686980.md	RB1 recruits APC/C:Cdh1 complex to SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""RB1 recruits APC/C:Cdh1 complex to SKP2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	70	R-HSA-9687377	Defective RB1 does not form a complex with SKP2 and FZR1	yes	reactome/R-HSA-9687377.md	Defective RB1 does not form a complex with SKP2 and FZR1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""Defective RB1 does not form a complex with SKP2 and FZR1""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	71	R-HSA-9708517	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	yes	reactome/R-HSA-9708517.md	FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	72	R-HSA-9708525	BACH1:FBXL17 binds SCF(SKP2) complex	yes	reactome/R-HSA-9708525.md	BACH1:FBXL17 binds SCF(SKP2) complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Nucleoplasmic SKP2 in the curated Reactome reaction ""BACH1:FBXL17 binds SCF(SKP2) complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	77	R-HSA-8952618	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952618.md	AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	78	R-HSA-8952620	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952620.md	NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	79	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""CAND1 binds cytosolic CRL E3 ubiquitin ligases""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	80	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	81	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	82	R-HSA-8956200	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8956200.md	MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	83	R-HSA-983140	Transfer of Ub from E2 to substrate and release of E2	yes	reactome/R-HSA-983140.md	Transfer of Ub from E2 to substrate and release of E2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""Transfer of Ub from E2 to substrate and release of E2""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	84	R-HSA-983147	Release of E3 from polyubiquitinated substrate	yes	reactome/R-HSA-983147.md	Release of E3 from polyubiquitinated substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""Release of E3 from polyubiquitinated substrate""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	85	R-HSA-983156	Polyubiquitination of substrate	yes	reactome/R-HSA-983156.md	Polyubiquitination of substrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""Polyubiquitination of substrate""."
human	SKP2	genes/human/SKP2/SKP2-ai-review.yaml	SKP2	Q13309	NCBITaxon:9606	Homo sapiens	86	R-HSA-983157	Interaction of E3 with substrate and E2-Ub complex	yes	reactome/R-HSA-983157.md	Interaction of E3 with substrate and E2-Ub complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosolic SCF(SKP2) in the curated Reactome reaction ""Interaction of E3 with substrate and E2-Ub complex""."
human	SLC14A1	genes/human/SLC14A1/SLC14A1-ai-review.yaml	SLC14A1	Q13336	NCBITaxon:9606	Homo sapiens	9	R-HSA-549127	SLC-mediated transport of organic cations	yes	reactome/R-HSA-549127.md	SLC-mediated transport of organic cations	Homo sapiens	GO:0015837	amine transport	TAS	involved_in	BP	false		REMOVE	"This annotation appears to be a misannotation. The Reactome pathway R-HSA-549127 is ""SLC-mediated transport of organic cations"" which involves OCT1-3 (SLC22 family), not SLC14A1. SLC14A1 is a urea transporter, not an organic cation or amine transporter. There is no experimental evidence that SLC14A1 transports amines."
human	SLC14A1	genes/human/SLC14A1/SLC14A1-ai-review.yaml	SLC14A1	Q13336	NCBITaxon:9606	Homo sapiens	18	R-HSA-444126	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively	yes	reactome/R-HSA-444126.md	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively	Homo sapiens	GO:0015204	urea transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	The Reactome pathway correctly describes HUT11 (SLC14A1) as an erythrocyte-specific urea transporter mediating rapid urea movement across cell membranes.
human	SLC14A1	genes/human/SLC14A1/SLC14A1-ai-review.yaml	SLC14A1	Q13336	NCBITaxon:9606	Homo sapiens	22	R-HSA-444126	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively	yes	reactome/R-HSA-444126.md	HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The Reactome pathway describes urea transport across cell membranes, implicitly indicating plasma membrane localization for the transporter.
human	SLC19A2	genes/human/SLC19A2/SLC19A2-ai-review.yaml	SLC19A2	O60779	NCBITaxon:9606	Homo sapiens	17	R-HSA-196819	Vitamin B1 (thiamin) metabolism	yes	reactome/R-HSA-196819.md	Vitamin B1 (thiamin) metabolism	Homo sapiens	GO:0042723	thiamine-containing compound metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"THTR-1 imports thiamine, the substrate that is subsequently phosphorylated to the coenzyme thiamine pyrophosphate; membership in the Reactome ""Vitamin B1 (thiamin) metabolism"" pathway is a reasonable higher-level process placement but broader than the transporter's specific function. Retained as non-core pathway context."
human	SLC19A2	genes/human/SLC19A2/SLC19A2-ai-review.yaml	SLC19A2	O60779	NCBITaxon:9606	Homo sapiens	25	R-HSA-199626	SLC19A2/3 transport extracellular THMN to cytosol	yes	reactome/R-HSA-199626.md	SLC19A2/3 transport extracellular THMN to cytosol	Homo sapiens	GO:0015234	thiamine transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome models SLC19A2 (THTR1) as a plasma-membrane transporter of extracellular thiamine to the cytosol; matches the core molecular function.
human	SLC19A2	genes/human/SLC19A2/SLC19A2-ai-review.yaml	SLC19A2	O60779	NCBITaxon:9606	Homo sapiens	30	R-HSA-199626	SLC19A2/3 transport extracellular THMN to cytosol	yes	reactome/R-HSA-199626.md	SLC19A2/3 transport extracellular THMN to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places SLC19A2 at the plasma membrane, consistent with the experimentally established location. Retained as core.
human	SLC19A3	genes/human/SLC19A3/SLC19A3-ai-review.yaml	SLC19A3	Q9BZV2	NCBITaxon:9606	Homo sapiens	10	R-HSA-196819	Vitamin B1 (thiamin) metabolism	yes	reactome/R-HSA-196819.md	Vitamin B1 (thiamin) metabolism	Homo sapiens	GO:0042723	thiamine-containing compound metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway-level placement of SLC19A3 within vitamin B1 metabolism. The transporter participates in thiamine homeostasis but does not itself metabolize (interconvert) thiamine-containing compounds; the specific thiamine-transport process terms capture its actual role more precisely. Retain as non-core context.
human	SLC19A3	genes/human/SLC19A3/SLC19A3-ai-review.yaml	SLC19A3	Q9BZV2	NCBITaxon:9606	Homo sapiens	19	R-HSA-199626	SLC19A2/3 transport extracellular THMN to cytosol	yes	reactome/R-HSA-199626.md	SLC19A2/3 transport extracellular THMN to cytosol	Homo sapiens	GO:0015234	thiamine transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of the core molecular function: SLC19A3 mediates transport of extracellular thiamine into the cytosol at the plasma membrane. Core MF; accept.
human	SLC19A3	genes/human/SLC19A3/SLC19A3-ai-review.yaml	SLC19A3	Q9BZV2	NCBITaxon:9606	Homo sapiens	21	R-HSA-196819	Vitamin B1 (thiamin) metabolism	yes	reactome/R-HSA-196819.md	Vitamin B1 (thiamin) metabolism	Homo sapiens	GO:0042723	thiamine-containing compound metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Duplicate of the earlier Reactome pathway-level thiamine-metabolism placement (also appears with TAS from R-HSA-196819). As above, the transporter participates in thiamine homeostasis but is not a metabolic (interconverting) enzyme; retain as non-core context.
human	SLC19A3	genes/human/SLC19A3/SLC19A3-ai-review.yaml	SLC19A3	Q9BZV2	NCBITaxon:9606	Homo sapiens	22	R-HSA-199626	SLC19A2/3 transport extracellular THMN to cytosol	yes	reactome/R-HSA-199626.md	SLC19A2/3 transport extracellular THMN to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of plasma-membrane localization, the core cellular location where SLC19A3 mediates thiamine uptake. Accept.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	19	R-HSA-549127	SLC-mediated transport of organic cations	yes	reactome/R-HSA-549127.md	SLC-mediated transport of organic cations	Homo sapiens	GO:0015837	amine transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-asserted involvement in the broad process amine transport (SLC-mediated transport of organic cations). Correct but general; the specific OCTN2 process is carnitine transmembrane transport.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	20	R-HSA-165026	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol	no				GO:1902603	carnitine transmembrane transport	TAS	involved_in	BP	false		ACCEPT	Reactome-asserted involvement in carnitine transmembrane transport (OCTN2 transports carnitine from extracellular space to cytosol). This is the core biological process of OCTN2.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	58	R-HSA-549297	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol	no				GO:0015226	carnitine transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome assertion that SLC22A5 (with SLC22A4/15/16) cotransports carnitine and Na+ from extracellular region to cytosol. Core molecular function.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	59	R-HSA-5625674	Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol	no				GO:0015226	carnitine transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome assertion (defective SLC22A5 does not cotransport carnitine/Na+) referencing the normal carnitine transporter activity of OCTN2. Core molecular function.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	69	R-HSA-5625674	Defective SLC22A5 does not cotransport CAR, Na+ from extracellular region to cytosol	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted plasma-membrane localization of SLC22A5. Consistent with the established core localization.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	71	R-HSA-165026	OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted plasma-membrane localization of SLC22A5 (in the carnitine transport reaction). Consistent with core localization.
human	SLC22A5	genes/human/SLC22A5/SLC22A5-ai-review.yaml	SLC22A5	O76082	NCBITaxon:9606	Homo sapiens	72	R-HSA-549297	SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted plasma-membrane localization of SLC22A5 (in the carnitine/Na+ cotransport reaction). Consistent with core localization.
human	SLC25A1	genes/human/SLC25A1/SLC25A1-ai-review.yaml	SLC25A1	P53007	NCBITaxon:9606	Homo sapiens	7	R-HSA-9955298	SLC-mediated transport of organic anions	yes	reactome/R-HSA-9955298.md	SLC-mediated transport of organic anions	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Reactome (TAS) placement in the generic ""SLC-mediated transport of organic anions"" pathway. Correct but very broad; superseded by the specific mitochondrial citrate transmembrane transport term."
human	SLC25A1	genes/human/SLC25A1/SLC25A1-ai-review.yaml	SLC25A1	P53007	NCBITaxon:9606	Homo sapiens	13	R-HSA-372449	SLC25A1 may exchange mitochondrial PEP for cytosolic anion	yes	reactome/R-HSA-372449.md	SLC25A1 may exchange mitochondrial PEP for cytosolic anion	Homo sapiens	GO:0015142	tricarboxylic acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation to tricarboxylic acid transmembrane transporter activity, from the hypothetical PEP/citrate exchange reaction. This is a correct broader parent of the specific citrate transporter activity; kept as a non-core (true parent) molecular function.
human	SLC25A1	genes/human/SLC25A1/SLC25A1-ai-review.yaml	SLC25A1	P53007	NCBITaxon:9606	Homo sapiens	14	R-HSA-75849	SLC25A1 exchanges CIT and MAL	yes	reactome/R-HSA-75849.md	SLC25A1 exchanges CIT and MAL	Homo sapiens	GO:0015142	tricarboxylic acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation to tricarboxylic acid transmembrane transporter activity, from the SLC25A1 citrate/malate exchange reaction. Correct broader parent of the specific citrate transporter activity; kept as a non-core (true parent) molecular function.
human	SLC25A10	genes/human/SLC25A10/SLC25A10-ai-review.yaml	SLC25A10	Q9UBX3	NCBITaxon:9606	Homo sapiens	22	R-HSA-1614517	Sulfide oxidation to sulfate	yes	reactome/R-HSA-1614517.md	Sulfide oxidation to sulfate	Homo sapiens	GO:0019418	sulfide oxidation	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Derived from Reactome pathway participation (DIC provides the dicarboxylate/sulfate antiport step that lets sulfate exit mitochondria in the sulfide-oxidation pathway). DIC does not itself perform sulfide oxidation, which is a pathway-level process carried out by oxidoreductases; this is an over-annotation of the transporter to a downstream pathway.
human	SLC25A10	genes/human/SLC25A10/SLC25A10-ai-review.yaml	SLC25A10	Q9UBX3	NCBITaxon:9606	Homo sapiens	23	R-HSA-9955298	SLC-mediated transport of organic anions	yes	reactome/R-HSA-9955298.md	SLC-mediated transport of organic anions	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Correct but maximally generic Reactome-derived process term (SLC-mediated transport of organic anions). True of any SLC transporter; uninformative about DIC's specific role. Retained as non-core.
human	SLC25A10	genes/human/SLC25A10/SLC25A10-ai-review.yaml	SLC25A10	Q9UBX3	NCBITaxon:9606	Homo sapiens	27	R-HSA-1614546	Sulfate is exported to the cytosol in exchange for dicarboxylate	yes	reactome/R-HSA-1614546.md	Sulfate is exported to the cytosol in exchange for dicarboxylate	Homo sapiens	GO:0005310	dicarboxylic acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome-asserted dicarboxylate transporter activity (sulfate exported in exchange for dicarboxylate/malate). Correct at the general level; the specific MF is the dicarboxylate:phosphate antiporter activity captured in core functions.
human	SLC25A10	genes/human/SLC25A10/SLC25A10-ai-review.yaml	SLC25A10	Q9UBX3	NCBITaxon:9606	Homo sapiens	29	R-HSA-1614546	Sulfate is exported to the cytosol in exchange for dicarboxylate	yes	reactome/R-HSA-1614546.md	Sulfate is exported to the cytosol in exchange for dicarboxylate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization, consistent with the core localization. Correct.
human	SLC25A10	genes/human/SLC25A10/SLC25A10-ai-review.yaml	SLC25A10	Q9UBX3	NCBITaxon:9606	Homo sapiens	30	R-HSA-372843	SLC25A10 mediates exchange of malate and phosphate	yes	reactome/R-HSA-372843.md	SLC25A10 mediates exchange of malate and phosphate	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted inner-membrane localization (SLC25A10 mediates exchange of malate and phosphate). Consistent with the core localization. Correct.
human	SLC25A11	genes/human/SLC25A11/SLC25A11-ai-review.yaml	SLC25A11	Q02978	NCBITaxon:9606	Homo sapiens	19	R-HSA-198440	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane	yes	reactome/R-HSA-198440.md	SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement placing OGC in the inner mitochondrial membrane, where it exchanges malate and 2-oxoglutarate. Consistent with the core location. Accept.
human	SLC25A11	genes/human/SLC25A11/SLC25A11-ai-review.yaml	SLC25A11	Q02978	NCBITaxon:9606	Homo sapiens	20	R-HSA-376851	SLC25A11 exchanges 2-OG and MAL	yes	reactome/R-HSA-376851.md	SLC25A11 exchanges 2-OG and MAL	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the inner-membrane 2-OG/malate exchange reaction. Consistent with the core location. Accept.
human	SLC25A12	genes/human/SLC25A12/SLC25A12-ai-review.yaml	SLC25A12	O75746	NCBITaxon:9606	Homo sapiens	41	R-HSA-372448	SLC25A12,13 exchange L-Glu and L-Asp	yes	reactome/R-HSA-372448.md	SLC25A12,13 exchange L-Glu and L-Asp	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the carrier in the mitochondrial inner membrane (SLC25A12,13 exchange L-Glu and L-Asp). Consistent with the core location.
human	SLC25A13	genes/human/SLC25A13/SLC25A13-ai-review.yaml	SLC25A13	Q9UJS0	NCBITaxon:9606	Homo sapiens	36	R-HSA-372448	SLC25A12,13 exchange L-Glu and L-Asp	yes	reactome/R-HSA-372448.md	SLC25A12,13 exchange L-Glu and L-Asp	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) for mitochondrial inner-membrane localization, from the Reactome reaction in which SLC25A12/13 exchange L-Glu and L-Asp. Core location.
human	SLC25A15	genes/human/SLC25A15/SLC25A15-ai-review.yaml	SLC25A15	Q9Y619	NCBITaxon:9606	Homo sapiens	8	R-HSA-70635	Urea cycle	yes	reactome/R-HSA-70635.md	Urea cycle	Homo sapiens	GO:0000050	urea cycle	TAS	involved_in	BP	false		ACCEPT	Reactome-traceable assignment placing ORNT1 in the urea cycle, which it connects by shuttling ornithine and citrulline across the inner mitochondrial membrane.
human	SLC25A15	genes/human/SLC25A15/SLC25A15-ai-review.yaml	SLC25A15	Q9Y619	NCBITaxon:9606	Homo sapiens	9	R-HSA-9956519	SLC25A15 variants don't translocate ornithine and citrulline	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-traceable assignment of mitochondrial inner membrane location (from the Reactome reaction describing ornithine/citrulline translocation).
human	SLC25A15	genes/human/SLC25A15/SLC25A15-ai-review.yaml	SLC25A15	Q9Y619	NCBITaxon:9606	Homo sapiens	10	R-HSA-9956519	SLC25A15 variants don't translocate ornithine and citrulline	no				GO:0000064	L-ornithine transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome-traceable assignment of the core L-ornithine transmembrane transporter activity.
human	SLC25A15	genes/human/SLC25A15/SLC25A15-ai-review.yaml	SLC25A15	Q9Y619	NCBITaxon:9606	Homo sapiens	23	R-HSA-70634	ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-traceable assignment of mitochondrial inner membrane location, from the reaction describing cytosolic/mitochondrial ornithine-citrulline exchange.
human	SLC25A19	genes/human/SLC25A19/SLC25A19-ai-review.yaml	SLC25A19	Q9HC21	NCBITaxon:9606	Homo sapiens	11	R-HSA-196819	Vitamin B1 (thiamin) metabolism	yes	reactome/R-HSA-196819.md	Vitamin B1 (thiamin) metabolism	Homo sapiens	GO:0042723	thiamine-containing compound metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of SLC25A19 within vitamin B1 (thiamin) metabolism. Correct pathway context but a broad process relative to the specific TPP transport function; non-core.
human	SLC25A19	genes/human/SLC25A19/SLC25A19-ai-review.yaml	SLC25A19	Q9HC21	NCBITaxon:9606	Homo sapiens	24	R-HSA-8875838	SLC25A19 transports ThDP from cytosol to mitochondrial matrix	yes	reactome/R-HSA-8875838.md	SLC25A19 transports ThDP from cytosol to mitochondrial matrix	Homo sapiens	GO:0090422	thiamine pyrophosphate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of the core TPP transporter activity, describing transport of ThDP from cytosol to the mitochondrial matrix. Consistent with the experimental evidence; supports the core MF.
human	SLC25A19	genes/human/SLC25A19/SLC25A19-ai-review.yaml	SLC25A19	Q9HC21	NCBITaxon:9606	Homo sapiens	25	R-HSA-8875838	SLC25A19 transports ThDP from cytosol to mitochondrial matrix	yes	reactome/R-HSA-8875838.md	SLC25A19 transports ThDP from cytosol to mitochondrial matrix	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to the mitochondrial inner membrane, the specific and correct location for this SLC25 carrier. Core cellular component.
human	SLC25A20	genes/human/SLC25A20/SLC25A20-ai-review.yaml	SLC25A20	O43772	NCBITaxon:9606	Homo sapiens	9	R-HSA-200425	Carnitine shuttle	yes	reactome/R-HSA-200425.md	Carnitine shuttle	Homo sapiens	GO:0006853	carnitine shuttle	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion that SLC25A20 acts in the carnitine shuttle; duplicate of the IEA call and equally correct.
human	SLC25A20	genes/human/SLC25A20/SLC25A20-ai-review.yaml	SLC25A20	O43772	NCBITaxon:9606	Homo sapiens	12	R-HSA-9971094	SLC25A20 exports excess acyl-CAR	no				GO:0005476	carnitine:O-acyl-L-carnitine antiporter activity	TAS	enables	MF	false		ACCEPT	Reactome traceable assertion of the carnitine:acylcarnitine antiporter activity; duplicate of the EXP call and equally correct.
human	SLC25A20	genes/human/SLC25A20/SLC25A20-ai-review.yaml	SLC25A20	O43772	NCBITaxon:9606	Homo sapiens	17	R-HSA-200424	Exchange of acylcarnitine and carnitine across the inner mitochondrial membrane	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion that the SLC25A20 carrier is embedded in the inner mitochondrial membrane; core location.
human	SLC25A20	genes/human/SLC25A20/SLC25A20-ai-review.yaml	SLC25A20	O43772	NCBITaxon:9606	Homo sapiens	18	R-HSA-9971094	SLC25A20 exports excess acyl-CAR	no				GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion of inner-membrane localization; duplicate of the R-HSA-200424 call and equally correct.
human	SLC25A21	genes/human/SLC25A21/SLC25A21-ai-review.yaml	SLC25A21	Q9BQT8	NCBITaxon:9606	Homo sapiens	3	R-HSA-71064	Lysine catabolism	yes	reactome/R-HSA-71064.md	Lysine catabolism	Homo sapiens	GO:0019477	L-lysine catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation linking SLC25A21 to lysine catabolism. 2-oxoadipate (alpha-ketoadipate) is a key intermediate of the lysine degradation pathway, and SLC25A21 provides the inner-membrane transport step that carries it into the matrix. The annotation is biologically correct as pathway context, but SLC25A21 is a transporter rather than a lysine-catabolic enzyme, so this is kept as a non-core, participatory role rather than a core molecular function.
human	SLC25A21	genes/human/SLC25A21/SLC25A21-ai-review.yaml	SLC25A21	Q9BQT8	NCBITaxon:9606	Homo sapiens	10	R-HSA-372480	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]	yes	reactome/R-HSA-372480.md	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]	Homo sapiens	GO:0015139	alpha-ketoglutarate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome captures the SLC25A21-mediated exchange reaction (2-oxoglutarate matrix + 2-oxoadipate cytosol <=> 2-oxoglutarate cytosol + 2-oxoadipate matrix). This is the same core transporter activity supported by the experimental annotations. Accepted.
human	SLC25A21	genes/human/SLC25A21/SLC25A21-ai-review.yaml	SLC25A21	Q9BQT8	NCBITaxon:9606	Homo sapiens	11	R-HSA-372480	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]	yes	reactome/R-HSA-372480.md	2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome places the SLC25A21 exchange activity at the inner mitochondrial membrane, consistent with UniProt and the ISS/IEA/HTP annotations. Core subcellular location.
human	SLC25A22	genes/human/SLC25A22/SLC25A22-ai-review.yaml	SLC25A22	Q9H936	NCBITaxon:9606	Homo sapiens	14	R-HSA-442660	SLC-mediated transport of neurotransmitters	yes	reactome/R-HSA-442660.md	SLC-mediated transport of neurotransmitters	Homo sapiens	GO:0006836	neurotransmitter transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Over-annotation. The cited Reactome node (R-HSA-442660) describes the SLC6 family of plasma-membrane neurotransmitter transporters that terminate synaptic signaling, a distinct process from SLC25A22's mitochondrial inner-membrane glutamate/H+ symport. GC-1 handles glutamate as a mitochondrial metabolite, not as a synaptic neurotransmitter being cleared from the cleft. Mark as over-annotated.
human	SLC25A22	genes/human/SLC25A22/SLC25A22-ai-review.yaml	SLC25A22	Q9H936	NCBITaxon:9606	Homo sapiens	15	R-HSA-9856872	Malate-aspartate shuttle	yes	reactome/R-HSA-9856872.md	Malate-aspartate shuttle	Homo sapiens	GO:0043490	malate-aspartate shuttle	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-asserted participation in the malate-aspartate shuttle via the glutamate/H+ import leg. Valid pathway context but not the core molecular function. Keep as non-core (duplicate of the IBA malate-aspartate shuttle call).
human	SLC25A22	genes/human/SLC25A22/SLC25A22-ai-review.yaml	SLC25A22	Q9H936	NCBITaxon:9606	Homo sapiens	20	R-HSA-8875623	SLC25A18,22 import L-Glu, H+	yes	reactome/R-HSA-8875623.md	SLC25A18,22 import L-Glu, H+	Homo sapiens	GO:0005280	amino acid:proton symporter activity	TAS	enables	MF	false		ACCEPT	Reactome-asserted amino acid:proton symporter activity for the SLC25A18/SLC25A22 glutamate/H+ import reaction. Duplicate of the IDA call for the same core MF. Accept.
human	SLC25A22	genes/human/SLC25A22/SLC25A22-ai-review.yaml	SLC25A22	Q9H936	NCBITaxon:9606	Homo sapiens	21	R-HSA-8875623	SLC25A18,22 import L-Glu, H+	yes	reactome/R-HSA-8875623.md	SLC25A18,22 import L-Glu, H+	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted mitochondrial inner-membrane location for the glutamate/H+ import reaction. Consistent with the core location. Accept.
human	SLC25A26	genes/human/SLC25A26/SLC25A26-ai-review.yaml	SLC25A26	Q70HW3	NCBITaxon:9606	Homo sapiens	7	R-HSA-549127	SLC-mediated transport of organic cations	yes	reactome/R-HSA-549127.md	SLC-mediated transport of organic cations	Homo sapiens	GO:0015837	amine transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"The cited Reactome pathway R-HSA-549127 is ""SLC-mediated transport of organic cations"" (SLC22/OCT family, ergothioneine and carnitine transport), not the SAMC AdoMet/AdoHcy exchange (which is Reactome R-HSA-8855062). ""amine transport"" mischaracterizes the substrate; SAM is a sulfonium metabolite transported by antiport with SAH, not a generic amine. This is an over-annotation via a mismatched pathway grouping."
human	SLC25A26	genes/human/SLC25A26/SLC25A26-ai-review.yaml	SLC25A26	Q70HW3	NCBITaxon:9606	Homo sapiens	19	R-HSA-8855062	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy	yes	reactome/R-HSA-8855062.md	SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome traceable assertion (R-HSA-8855062, ""SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy"") placing SAMC at the inner mitochondrial membrane. Correct core localization, consistent with experimental IDA evidence."
human	SLC25A32	genes/human/SLC25A32/SLC25A32-ai-review.yaml	SLC25A32	Q9H2D1	NCBITaxon:9606	Homo sapiens	12	R-HSA-196757	Metabolism of folate and pterines	yes	reactome/R-HSA-196757.md	Metabolism of folate and pterines	Homo sapiens	GO:0046655	folic acid metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome curator-asserted process reflecting SLC25A32's role in folate/pterine metabolism. SLC25A32 contributes to mitochondrial folate homeostasis and folate-mediated one-carbon metabolism, but does so largely indirectly via FAD-dependent flavoenzymes. Real association; keep as non-core.
human	SLC25A32	genes/human/SLC25A32/SLC25A32-ai-review.yaml	SLC25A32	Q9H2D1	NCBITaxon:9606	Homo sapiens	17	R-HSA-200680	SLC25A32 transports THF from cytosol to mitochondrial matrix	yes	reactome/R-HSA-200680.md	SLC25A32 transports THF from cytosol to mitochondrial matrix	Homo sapiens	GO:0008517	folic acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome curator-asserted folate (THF) transporter activity, reflecting the original identification of SLC25A32 as the mitochondrial folate transporter. UniProt now notes this was superseded as the primary function by FAD transport, but folate transporter activity remains a documented, curator-supported activity of the protein. Keep as non-core rather than removing an experimental/curator TAS call; the specific FAD activity is the core function.
human	SLC25A32	genes/human/SLC25A32/SLC25A32-ai-review.yaml	SLC25A32	Q9H2D1	NCBITaxon:9606	Homo sapiens	18	R-HSA-200720	SLC25A32 transports THF from mitochondrial matrix to cytosol	yes	reactome/R-HSA-200720.md	SLC25A32 transports THF from mitochondrial matrix to cytosol	Homo sapiens	GO:0008517	folic acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Duplicate Reactome TAS folate transporter activity annotation (matrix-to-cytosol direction of the same reversible THF transport reaction). Same assessment as R-HSA-200680: real curator assertion, but non-core relative to FAD transport.
human	SLC25A32	genes/human/SLC25A32/SLC25A32-ai-review.yaml	SLC25A32	Q9H2D1	NCBITaxon:9606	Homo sapiens	23	R-HSA-200680	SLC25A32 transports THF from cytosol to mitochondrial matrix	yes	reactome/R-HSA-200680.md	SLC25A32 transports THF from cytosol to mitochondrial matrix	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome curator-asserted inner-membrane localization, agreeing with experimental and UniProt evidence. Core localization. Accept.
human	SLC25A32	genes/human/SLC25A32/SLC25A32-ai-review.yaml	SLC25A32	Q9H2D1	NCBITaxon:9606	Homo sapiens	24	R-HSA-200720	SLC25A32 transports THF from mitochondrial matrix to cytosol	yes	reactome/R-HSA-200720.md	SLC25A32 transports THF from mitochondrial matrix to cytosol	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome TAS inner-membrane localization (matrix-to-cytosol reaction). Same core, correct assessment as R-HSA-200680. Accept.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	26	R-HSA-166187	Mitochondrial Uncoupling	yes	reactome/R-HSA-166187.md	Mitochondrial Uncoupling	Homo sapiens	GO:1990845	adaptive thermogenesis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome-curated (Mitochondrial Uncoupling) assertion of the thermogenic role of ANT via proton leak. Consistent with UniProt; secondary/non-core relative to ADP/ATP antiport.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	34	R-HSA-180905	Association of Vpr with ANT1	yes	reactome/R-HSA-180905.md	Association of Vpr with ANT1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization (in the context of HIV-1 Vpr association). Correct site of action.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	35	R-HSA-5250209	ARL2:GTP:ARL2BP binds SLC25A4	yes	reactome/R-HSA-5250209.md	ARL2:GTP:ARL2BP binds SLC25A4	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization (ARL2:GTP:ARL2BP binding SLC25A4). Correct site of action.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	36	R-HSA-5672027	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane	yes	reactome/R-HSA-5672027.md	ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization for the ATP/ADP exchange reaction. Correct site of action.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	37	R-HSA-9864415	AAC1 imports a proton	yes	reactome/R-HSA-9864415.md	AAC1 imports a proton	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated inner-membrane localization (proton import reaction). Correct site of action.
human	SLC25A4	genes/human/SLC25A4/SLC25A4-ai-review.yaml	SLC25A4	P12235	NCBITaxon:9606	Homo sapiens	38	R-HSA-9864415	AAC1 imports a proton	yes	reactome/R-HSA-9864415.md	AAC1 imports a proton	Homo sapiens	GO:0015078	proton transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	"Reactome-curated proton-transport activity (""AAC1 imports a proton""), corresponding to the secondary uncoupling/proton-leak function of ANT. A genuine but non-core molecular function."
human	SLC25A42	genes/human/SLC25A42/SLC25A42-ai-review.yaml	SLC25A42	Q86VD7	NCBITaxon:9606	Homo sapiens	9	R-HSA-199220	Vitamin B5 (pantothenate) metabolism	yes	reactome/R-HSA-199220.md	Vitamin B5 (pantothenate) metabolism	Homo sapiens	GO:0015939	pantothenate metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places SLC25A42 in vitamin B5 (pantothenate)/CoA metabolism because CoA is the downstream product of pantothenate. The transporter participates in CoA compartmentalization rather than in pantothenate metabolism per se; retained as a valid pathway-level (non-core) association.
human	SLC25A42	genes/human/SLC25A42/SLC25A42-ai-review.yaml	SLC25A42	Q86VD7	NCBITaxon:9606	Homo sapiens	16	R-HSA-9837333	SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP	yes	reactome/R-HSA-9837333.md	SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization tied to the annotated reaction in which SLC25A42 exchanges cytosolic CoA-SH for matrix ADP. Correct and specific.
human	SLC25A5	genes/human/SLC25A5/SLC25A5-ai-review.yaml	SLC25A5	P05141	NCBITaxon:9606	Homo sapiens	53	R-HSA-163215	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane	yes	reactome/R-HSA-163215.md	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of the SLC25A5,6 ADP/ATP exchange reaction at the inner membrane. Correct core location.
human	SLC25A5	genes/human/SLC25A5/SLC25A5-ai-review.yaml	SLC25A5	P05141	NCBITaxon:9606	Homo sapiens	54	R-HSA-180905	Association of Vpr with ANT1	yes	reactome/R-HSA-180905.md	Association of Vpr with ANT1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (Vpr/ANT association) placing ANT2 at the inner membrane. Correct location; the pathway context (HIV-1 Vpr) is a host-virus interaction, not a core function.
human	SLC25A5	genes/human/SLC25A5/SLC25A5-ai-review.yaml	SLC25A5	P05141	NCBITaxon:9606	Homo sapiens	55	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (LONP1 binds inner-membrane proteins) placing ANT2 at the inner membrane. Correct location.
human	SLC25A5	genes/human/SLC25A5/SLC25A5-ai-review.yaml	SLC25A5	P05141	NCBITaxon:9606	Homo sapiens	56	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (LONP1 degrades inner-membrane proteins) placing ANT2 at the inner membrane. Correct location.
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	29	R-HSA-163215	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane	yes	reactome/R-HSA-163215.md	SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for the SLC25A5,6 ADP/ATP exchange reaction; correctly places ANT3 in the mitochondrial inner membrane. Consistent with the core localization.
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	30	R-HSA-168878	PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis	yes	reactome/R-HSA-168878.md	PB1-F2 binds to the mitochondrial adenine nucleotide translocator 3 ANT3, inducing apoptosis	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (PB1-F2 binding to ANT3 inducing apoptosis) placing ANT3 in the mitochondrial inner membrane. Correct core localization.
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	31	R-HSA-180905	Association of Vpr with ANT1	yes	reactome/R-HSA-180905.md	Association of Vpr with ANT1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing ANT in the mitochondrial inner membrane. Correct core localization (redundant with other inner-membrane annotations).
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	32	R-HSA-1955380	TIMM9:TIMM10 transfers proteins to TIMM22	yes	reactome/R-HSA-1955380.md	TIMM9:TIMM10 transfers proteins to TIMM22	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (mitochondrial protein import module) placing ANT3 in the mitochondrial inner membrane. Correct core localization.
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	33	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (LONP1 binds inner-membrane proteins) placing ANT3 in the mitochondrial inner membrane. Correct core localization.
human	SLC25A6	genes/human/SLC25A6/SLC25A6-ai-review.yaml	SLC25A6	P12236	NCBITaxon:9606	Homo sapiens	34	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (LONP1 degrades inner-membrane proteins) placing ANT3 in the mitochondrial inner membrane. Correct core localization.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	20	R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	yes	reactome/R-HSA-193368.md	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of SLC27A5 within bile acid/bile salt synthesis (via 7alpha-hydroxycholesterol). SLC27A5 contributes the CoA-activation step that primes bile acids for conjugation within the biosynthetic pathway.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	21	R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	yes	reactome/R-HSA-193775.md	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Homo sapiens	GO:0006699	bile acid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) placement of SLC27A5 within bile acid/bile salt synthesis (via 24-hydroxycholesterol). As above, SLC27A5 provides the CoA-activation step for bile acid conjugation.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	22	R-HSA-159418	Recycling of bile acids and salts	yes	reactome/R-HSA-159418.md	Recycling of bile acids and salts	Homo sapiens	GO:0015721	bile acid and bile salt transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement within recycling of bile acids and salts. SLC27A5 re-activates C24 bile acids returning via the enterohepatic circulation, functioning within the recycling pathway rather than as a bile-acid transporter per se.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	23	R-HSA-159425	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-159425.md	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0004467	long-chain fatty acid-CoA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) molecular-function assignment for the BACS reaction conjugating cytosolic cholate/chenodeoxycholate with CoA on the ER membrane. Correct core catalytic function.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	24	R-HSA-192137	THCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-192137.md	THCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0004467	long-chain fatty acid-CoA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) molecular-function assignment for the BACS reaction conjugating the C27 precursor THCA with CoA. Consistent with the enzyme's demonstrated ability to activate THCA.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	25	R-HSA-193407	DHCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-193407.md	DHCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0004467	long-chain fatty acid-CoA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) molecular-function assignment for the BACS reaction conjugating DHCA with CoA. Consistent with the enzyme's acyl-CoA ligase activity toward bile-acid precursors.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	26	R-HSA-193711	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-193711.md	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0004467	long-chain fatty acid-CoA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) molecular-function assignment for the BACS reaction conjugating 3,7,24-THCA with CoA. Consistent with the enzyme's acyl-CoA ligase activity.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	27	R-HSA-193766	Bile-acyl-CoA conjugation reaction (SLC27A5 BACS)	no				GO:0004467	long-chain fatty acid-CoA ligase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) molecular-function assignment (bile-acyl-CoA conjugation reaction). The specific reaction id could not be verified in the current Reactome ContentService (returns 404, likely a retired/renumbered reaction), but the asserted ligase activity is the correct core function of SLC27A5.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	36	R-HSA-159425	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-159425.md	Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of the BACS reaction to the ER membrane, matching the experimentally determined localization.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	37	R-HSA-192137	THCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-192137.md	THCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of a BACS bile-acid CoA-conjugation reaction to the ER membrane.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	38	R-HSA-193407	DHCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-193407.md	DHCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of a BACS bile-acid CoA-conjugation reaction to the ER membrane.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	39	R-HSA-193711	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)	yes	reactome/R-HSA-193711.md	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of a BACS bile-acid CoA-conjugation reaction to the ER membrane.
human	SLC27A5	genes/human/SLC27A5/SLC27A5-ai-review.yaml	SLC27A5	Q9Y2P5	NCBITaxon:9606	Homo sapiens	40	R-HSA-193766	Bile-acyl-CoA conjugation reaction (SLC27A5 BACS)	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization of a BACS bile-acid CoA-conjugation reaction to the ER membrane. The specific reaction id could not be confirmed in the current Reactome release, but the ER-membrane localization is experimentally supported.
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	16	R-HSA-8931838	DAG1 glycosylations	yes	reactome/R-HSA-8931838.md	DAG1 glycosylations	Homo sapiens	GO:0006493	protein O-linked glycosylation	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (DAG1 glycosylations pathway) links SLC35A1 to O-linked glycosylation because the transporter supplies CMP-sialic acid (and CDP-ribitol) needed to build O-mannosyl/matriglycan structures. SLC35A1 is a transporter, not a glycosyltransferase, so this is a downstream process it supports rather than a direct activity.
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	17	R-HSA-9940804	SLC35A1,4 import CDP-ribitol	yes	reactome/R-HSA-9940804.md	SLC35A1,4 import CDP-ribitol	Homo sapiens	GO:0015218	pyrimidine nucleotide transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	"Reactome annotates this term for the reaction ""SLC35A1,4 import CDP-ribitol"", reflecting the By-similarity CDP-ribitol/CDP exchange activity that contributes CDP-ribitol for matriglycan synthesis. CDP-ribitol/CDP are pyrimidine nucleotides, so the term fits this secondary activity."
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	21	R-HSA-5651942	Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP	yes	reactome/R-HSA-5651942.md	Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP	Homo sapiens	GO:0005456	CMP-N-acetylneuraminate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	"Reactome (""Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP"") asserts the core CMP-sialic acid transporter activity in the disease context. Consistent with the core function."
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	22	R-HSA-727807	SLC35A1 exchanges CMP-Neu5Ac for CMP	yes	reactome/R-HSA-727807.md	SLC35A1 exchanges CMP-Neu5Ac for CMP	Homo sapiens	GO:0005456	CMP-N-acetylneuraminate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	"Reactome (""SLC35A1 exchanges CMP-Neu5Ac for CMP"") asserts the core CMP-sialic acid transporter activity. Consistent with the core function."
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	27	R-HSA-5651942	Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP	yes	reactome/R-HSA-5651942.md	Defective SLC35A1 does not exchange CMP-Neu5Ac for CMP	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi-membrane localization in the CDG2F disease-reaction context; consistent with the experimentally supported location.
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	28	R-HSA-727807	SLC35A1 exchanges CMP-Neu5Ac for CMP	yes	reactome/R-HSA-727807.md	SLC35A1 exchanges CMP-Neu5Ac for CMP	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi-membrane localization for the CMP-Neu5Ac/CMP exchange reaction; consistent with the experimentally supported location.
human	SLC35A1	genes/human/SLC35A1/SLC35A1-ai-review.yaml	SLC35A1	P78382	NCBITaxon:9606	Homo sapiens	29	R-HSA-9940804	SLC35A1,4 import CDP-ribitol	yes	reactome/R-HSA-9940804.md	SLC35A1,4 import CDP-ribitol	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome Golgi-membrane localization for the CDP-ribitol import reaction; consistent with the Golgi location.
human	SLC35B2	genes/human/SLC35B2/SLC35B2-ai-review.yaml	SLC35B2	Q8TB61	NCBITaxon:9606	Homo sapiens	11	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:1902558	5'-adenylyl sulfate transmembrane transport	TAS	involved_in	BP	false		MODIFY	This term is the wrong metabolite. GO:1902558 is transport of 5'-adenylyl sulfate (adenosine 5'-phosphosulfate, APS), which is the biosynthetic PRECURSOR of PAPS (APS + ATP -> PAPS), not the substrate of this Golgi antiporter. SLC35B2 transports PAPS, and the cited Reactome reaction itself describes PAPS:PAP exchange. The annotation should use the PAPS transmembrane transport term.
human	SLC35B2	genes/human/SLC35B2/SLC35B2-ai-review.yaml	SLC35B2	Q8TB61	NCBITaxon:9606	Homo sapiens	16	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Correct core molecular function, curated by Reactome, matching the experimentally demonstrated PAPS transporter activity.
human	SLC35B2	genes/human/SLC35B2/SLC35B2-ai-review.yaml	SLC35B2	Q8TB61	NCBITaxon:9606	Homo sapiens	17	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Correct core cellular component, curated by Reactome, consistent with all other evidence for Golgi-membrane localization.
human	SLC35B3	genes/human/SLC35B3/SLC35B3-ai-review.yaml	SLC35B3	Q9H1N7	NCBITaxon:9606	Homo sapiens	9	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:1902558	5'-adenylyl sulfate transmembrane transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome author statement annotating transport of 5'-adenylyl sulfate (APS, adenosine 5'-phosphosulfate). The experimentally characterized substrate of SLC35B3 is PAPS (3'-phosphoadenosine 5'-phosphosulfate) / PAP, not APS; the UniProt Rhea reaction is a PAPS/PAP antiport. APS is a distinct, less-phosphorylated metabolite, so this term names the wrong substrate and is an over-annotation.
human	SLC35B3	genes/human/SLC35B3/SLC35B3-ai-review.yaml	SLC35B3	Q9H1N7	NCBITaxon:9606	Homo sapiens	12	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	Reactome author statement of PAPS transmembrane transporter activity, concordant with the experimental IDA annotation. Correct core molecular function.
human	SLC35B3	genes/human/SLC35B3/SLC35B3-ai-review.yaml	SLC35B3	Q9H1N7	NCBITaxon:9606	Homo sapiens	13	R-HSA-741449	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	yes	reactome/R-HSA-741449.md	SLC35B2,3 exchange cytosolic PAPS with Golgi PAP	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome author statement placing SLC35B3 at the Golgi membrane, where the PAPS/PAP exchange occurs. Concordant with experimental localization; correct core location.
human	SLC37A4	genes/human/SLC37A4/SLC37A4-ai-review.yaml	SLC37A4	O43826	NCBITaxon:9606	Homo sapiens	10	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	TAS (Reactome) annotation to gluconeogenesis. SLC37A4 supplies G6P to the ER-luminal glucose-6-phosphatase, carrying out the terminal, glucose-releasing step common to gluconeogenesis and glycogenolysis, so participation in gluconeogenesis is correct.
human	SLC37A4	genes/human/SLC37A4/SLC37A4-ai-review.yaml	SLC37A4	O43826	NCBITaxon:9606	Homo sapiens	12	R-HSA-3229118	Defective SLC37A4 does not exchange G6P and Pi across the ER membrane	no				GO:0061513	glucose 6-phosphate:phosphate antiporter activity	TAS	enables	MF	false		ACCEPT	TAS (Reactome) annotation for the G6P:Pi antiporter activity across the ER membrane. Consistent with the experimental evidence.
human	SLC37A4	genes/human/SLC37A4/SLC37A4-ai-review.yaml	SLC37A4	O43826	NCBITaxon:9606	Homo sapiens	26	R-HSA-3229118	Defective SLC37A4 does not exchange G6P and Pi across the ER membrane	no				GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) annotation for ER membrane localization, consistent with all experimental localization data.
human	SLC37A4	genes/human/SLC37A4/SLC37A4-ai-review.yaml	SLC37A4	O43826	NCBITaxon:9606	Homo sapiens	27	R-HSA-198513	SLC7A4 exchanges G6P for Pi across the ER membrane	yes	reactome/R-HSA-198513.md	SLC7A4 exchanges G6P for Pi across the ER membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) annotation for ER membrane localization (G6P/Pi exchange reaction across the ER membrane).
human	SLC3A1	genes/human/SLC3A1/SLC3A1-ai-review.yaml	SLC3A1	Q07837	NCBITaxon:9606	Homo sapiens	20	R-HSA-5655702	Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu	yes	reactome/R-HSA-5655702.md	Defective SLC3A1 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places defective SLC3A1 within the plasma-membrane SLC7A9-SLC3A1 exchange complex.
human	SLC3A1	genes/human/SLC3A1/SLC3A1-ai-review.yaml	SLC3A1	Q07837	NCBITaxon:9606	Homo sapiens	24	R-HSA-379432	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu	yes	reactome/R-HSA-379432.md	SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome models SLC3A1 in the plasma-membrane SLC7A9-SLC3A1 amino-acid exchange complex.
human	SLC3A1	genes/human/SLC3A1/SLC3A1-ai-review.yaml	SLC3A1	Q07837	NCBITaxon:9606	Homo sapiens	25	R-HSA-5660890	Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu	yes	reactome/R-HSA-5660890.md	Defective SLC7A9 (in SLC7A9:SLC3A1) does not exchange L-Arg, CySS-, L-Lys for L-Leu	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome places SLC3A1 in the plasma-membrane complex affected by defective SLC7A9.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	102	R-HSA-352191	SLC7A8-mediated uptake of neutral amino acids	yes	reactome/R-HSA-352191.md	SLC7A8-mediated uptake of neutral amino acids	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SLC7A8-mediated uptake with SLC3A2.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	103	R-HSA-352232	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol	yes	reactome/R-HSA-352232.md	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SLC7A5:SLC3A2 transport.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	104	R-HSA-375131	Basigin binds CD98 complex	yes	reactome/R-HSA-375131.md	Basigin binds CD98 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Basigin binding to CD98 complex at plasma membrane.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	105	R-HSA-376200	SLC7A10-mediated uptake of small neutral amino acids	yes	reactome/R-HSA-376200.md	SLC7A10-mediated uptake of small neutral amino acids	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SLC7A10-mediated uptake with SLC3A2.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	106	R-HSA-378513	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate	yes	reactome/R-HSA-378513.md	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SLC7A11-mediated cystine/glutamate exchange - system xc-.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	107	R-HSA-379415	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane	yes	reactome/R-HSA-379415.md	SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SLC7A7:SLC3A2 arginine/leucine exchange.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	108	R-HSA-379426	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine	yes	reactome/R-HSA-379426.md	SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	SLC7A6 (y+LAT2) with SLC3A2.
human	SLC3A2	genes/human/SLC3A2/SLC3A2-ai-review.yaml	SLC3A2	P08195	NCBITaxon:9606	Homo sapiens	109	R-HSA-5660910	Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane	yes	reactome/R-HSA-5660910.md	Defective SLC7A7 does not exchange L-Arg for L-Leu, Na+ across the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Defective SLC7A7 pathway annotation.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	34	R-HSA-5655733	Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region	yes	reactome/R-HSA-5655733.md	Defective SLC40A1 does not transport Fe2+ from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome pathway for defective SLC40A1.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	35	R-HSA-5655760	Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol	yes	reactome/R-HSA-5655760.md	Defective SLC40A1 does not transport Fe3+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane annotation from Reactome pathway.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	38	R-HSA-442368	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region	yes	reactome/R-HSA-442368.md	SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for iron transport reaction.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	39	R-HSA-5621402	Defective CP does not oxidise Fe2+ to Fe3+	yes	reactome/R-HSA-5621402.md	Defective CP does not oxidise Fe2+ to Fe3+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for ceruloplasmin deficiency pathway.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	40	R-HSA-904830	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region	yes	reactome/R-HSA-904830.md	SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for iron transport with ceruloplasmin.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	41	R-HSA-917891	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+	yes	reactome/R-HSA-917891.md	SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for iron oxidation reaction.
human	SLC40A1	genes/human/SLC40A1/SLC40A1-ai-review.yaml	SLC40A1	Q9NP59	NCBITaxon:9606	Homo sapiens	42	R-HSA-917933	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+	yes	reactome/R-HSA-917933.md	SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome annotation for hephaestin-mediated iron oxidation.
human	SLC52A1	genes/human/SLC52A1/SLC52A1-ai-review.yaml	SLC52A1	Q9NWF4	NCBITaxon:9606	Homo sapiens	10	R-HSA-196843	Vitamin B2 (riboflavin) metabolism	yes	reactome/R-HSA-196843.md	Vitamin B2 (riboflavin) metabolism	Homo sapiens	GO:0006771	riboflavin metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"TAS annotation from Reactome's broad ""Vitamin B2 (riboflavin) metabolism"" pathway grouping. SLC52A1 is a membrane transporter that moves intact riboflavin across the plasma membrane; it does not chemically transform riboflavin, so ""riboflavin metabolic process"" over-states its role. The transport role is better captured by GO:0032218 (riboflavin transport). Not removed (TAS), but marked as over-annotated."
human	SLC52A1	genes/human/SLC52A1/SLC52A1-ai-review.yaml	SLC52A1	Q9NWF4	NCBITaxon:9606	Homo sapiens	15	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0032217	riboflavin transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	TAS (Reactome) assertion of the core riboflavin transmembrane transporter activity, describing SLC52A1/2/3 transport of riboflavin from the extracellular region to the cytosol. Correct core function; retain.
human	SLC52A1	genes/human/SLC52A1/SLC52A1-ai-review.yaml	SLC52A1	Q9NWF4	NCBITaxon:9606	Homo sapiens	16	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) plasma membrane localization consistent with the transporter's site of action. Correct core localization; retain.
human	SLC52A2	genes/human/SLC52A2/SLC52A2-ai-review.yaml	SLC52A2	Q9HAB3	NCBITaxon:9606	Homo sapiens	9	R-HSA-196843	Vitamin B2 (riboflavin) metabolism	yes	reactome/R-HSA-196843.md	Vitamin B2 (riboflavin) metabolism	Homo sapiens	GO:0006771	riboflavin metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Placed in the Reactome ""Vitamin B2 (riboflavin) metabolism"" pathway. SLC52A2 is a membrane transporter, not a metabolic enzyme; it participates only by importing the vitamin. The specific, correct biological process is riboflavin transport (GO:0032218), which is already annotated. Annotating a transporter to the broad metabolic-process term is an over-annotation."
human	SLC52A2	genes/human/SLC52A2/SLC52A2-ai-review.yaml	SLC52A2	Q9HAB3	NCBITaxon:9606	Homo sapiens	13	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0032217	riboflavin transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	"Reactome TAS for the reaction ""SLC52A1,2,3 transport RIB from extracellular region to cytosol"". Correctly captures the core riboflavin transmembrane transporter activity of SLC52A2."
human	SLC52A2	genes/human/SLC52A2/SLC52A2-ai-review.yaml	SLC52A2	Q9HAB3	NCBITaxon:9606	Homo sapiens	18	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing the SLC52A1/2/3 riboflavin transport reaction at the plasma membrane. Consistent with the established localization; accepted as core component.
human	SLC52A3	genes/human/SLC52A3/SLC52A3-ai-review.yaml	SLC52A3	Q9NQ40	NCBITaxon:9606	Homo sapiens	11	R-HSA-196843	Vitamin B2 (riboflavin) metabolism	yes	reactome/R-HSA-196843.md	Vitamin B2 (riboflavin) metabolism	Homo sapiens	GO:0006771	riboflavin metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) placement of RFVT3 within vitamin B2 (riboflavin) metabolism. RFVT3 transports riboflavin across the membrane but does not chemically modify or metabolize it; the broad metabolic-process term generalizes beyond the specific transport role. Transport does contribute to whole-body riboflavin handling, so it is retained as a non-core parent process rather than removed. The specific and more appropriate BP terms are riboflavin transport (GO:0032218) and intestinal absorption (GO:0050892).
human	SLC52A3	genes/human/SLC52A3/SLC52A3-ai-review.yaml	SLC52A3	Q9NQ40	NCBITaxon:9606	Homo sapiens	28	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0032217	riboflavin transmembrane transporter activity	TAS	enables	MF	false		ACCEPT	"Reactome (TAS) statement of RFVT3 riboflavin transporter activity (reaction ""SLC52A1,2,3 transport RIB from extracellular region to cytosol""). Correct core molecular function."
human	SLC52A3	genes/human/SLC52A3/SLC52A3-ai-review.yaml	SLC52A3	Q9NQ40	NCBITaxon:9606	Homo sapiens	31	R-HSA-3165230	SLC52A1,2,3 transport RIB from extracellular region to cytosol	yes	reactome/R-HSA-3165230.md	SLC52A1,2,3 transport RIB from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) placement of RFVT3 transport at the plasma membrane (extracellular region to cytosol). Consistent with experimental data; core cellular location.
human	SLC6A6	genes/human/SLC6A6/SLC6A6-ai-review.yaml	SLC6A6	P31641	NCBITaxon:9606	Homo sapiens	29	R-HSA-352230	Amino acid transport across the plasma membrane	yes	reactome/R-HSA-352230.md	Amino acid transport across the plasma membrane	Homo sapiens	GO:0006865	amino acid transport	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway annotation placing SLC6A6 in plasma-membrane amino acid transport. Correct but a broad parent of the taurine-specific function; non-core generalization.
human	SLC6A6	genes/human/SLC6A6/SLC6A6-ai-review.yaml	SLC6A6	P31641	NCBITaxon:9606	Homo sapiens	61	R-HSA-351987	SLC6A6-mediated uptake of taurine and beta-alanine	yes	reactome/R-HSA-351987.md	SLC6A6-mediated uptake of taurine and beta-alanine	Homo sapiens	GO:0015171	amino acid transmembrane transporter activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome curator statement (SLC6A6-mediated uptake of taurine and beta-alanine). Correct but a general parent of the taurine-specific activity; non-core generalization.
human	SLC6A6	genes/human/SLC6A6/SLC6A6-ai-review.yaml	SLC6A6	P31641	NCBITaxon:9606	Homo sapiens	68	R-HSA-351987	SLC6A6-mediated uptake of taurine and beta-alanine	yes	reactome/R-HSA-351987.md	SLC6A6-mediated uptake of taurine and beta-alanine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome curator statement placing SLC6A6 at the plasma membrane; correct core location.
human	SLC6A8	genes/human/SLC6A8/SLC6A8-ai-review.yaml	SLC6A8	P48029	NCBITaxon:9606	Homo sapiens	11	R-HSA-71288	Creatine metabolism	yes	reactome/R-HSA-71288.md	Creatine metabolism	Homo sapiens	GO:0006600	creatine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	SLC6A8 is the transport step of cellular creatine handling and so participates in the creatine metabolic process. Reasonable high-level process annotation.
human	SLC6A8	genes/human/SLC6A8/SLC6A8-ai-review.yaml	SLC6A8	P48029	NCBITaxon:9606	Homo sapiens	21	R-HSA-200396	Creatine transport across the plasma membrane	yes	reactome/R-HSA-200396.md	Creatine transport across the plasma membrane	Homo sapiens	GO:0005309	creatine:sodium symporter activity	TAS	enables	MF	false		ACCEPT	Core molecular function captured via Reactome pathway curation. Correct.
human	SLC6A8	genes/human/SLC6A8/SLC6A8-ai-review.yaml	SLC6A8	P48029	NCBITaxon:9606	Homo sapiens	25	R-HSA-200396	Creatine transport across the plasma membrane	yes	reactome/R-HSA-200396.md	Creatine transport across the plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Correct plasma membrane localization captured via Reactome curation.
human	SLC7A11	genes/human/SLC7A11/SLC7A11-ai-review.yaml	SLC7A11	Q9UPY5	NCBITaxon:9606	Homo sapiens	27	R-HSA-375131	Basigin binds CD98 complex	yes	reactome/R-HSA-375131.md	Basigin binds CD98 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for basigin interactions at plasma membrane.
human	SLC7A11	genes/human/SLC7A11/SLC7A11-ai-review.yaml	SLC7A11	Q9UPY5	NCBITaxon:9606	Homo sapiens	28	R-HSA-378513	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate	yes	reactome/R-HSA-378513.md	SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SLC7A11-mediated cystine/glutamate exchange.
human	SLC7A11	genes/human/SLC7A11/SLC7A11-ai-review.yaml	SLC7A11	Q9UPY5	NCBITaxon:9606	Homo sapiens	29	R-HSA-9761841	AcK-NFE2L2-dependent SLC7A11 expression	yes	reactome/R-HSA-9761841.md	AcK-NFE2L2-dependent SLC7A11 expression	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome NFE2L2-dependent SLC7A11 expression pathway.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	21	R-HSA-8949215	Mitochondrial calcium ion transport	yes	reactome/R-HSA-8949215.md	Mitochondrial calcium ion transport	Homo sapiens	GO:0006851	mitochondrial calcium ion transmembrane transport	TAS	involved_in	BP	false		ACCEPT	Calcium movement across the mitochondrial inner membrane.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	22	R-HSA-425561	Sodium/Calcium exchangers	yes	reactome/R-HSA-425561.md	Sodium/Calcium exchangers	Homo sapiens	GO:0070588	calcium ion transmembrane transport	TAS	involved_in	BP	false		ACCEPT	Calcium ion transmembrane transport.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	28	R-HSA-425822	K+-independent Li+/Ca2+ exchanger transport	yes	reactome/R-HSA-425822.md	K+-independent Li+/Ca2+ exchanger transport	Homo sapiens	GO:0015368	calcium:monoatomic cation antiporter activity	TAS	enables	MF	false		ACCEPT	Calcium exchange against an unspecified monovalent cation.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	31	R-HSA-8949688	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)	yes	reactome/R-HSA-8949688.md	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)	Homo sapiens	GO:0005432	calcium:sodium antiporter activity	TAS	enables	MF	false		MODIFY	Calcium:sodium antiport, the classical assignment for NCLX.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	40	R-HSA-8949688	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)	yes	reactome/R-HSA-8949688.md	SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	NCLX resides in the mitochondrial inner membrane.
human	SLC8B1	genes/human/SLC8B1/SLC8B1-ai-review.yaml	SLC8B1	Q6J4K2	NCBITaxon:9606	Homo sapiens	45	R-HSA-425822	K+-independent Li+/Ca2+ exchanger transport	yes	reactome/R-HSA-425822.md	K+-independent Li+/Ca2+ exchanger transport	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Plasma membrane localisation.
human	SLX4	genes/human/SLX4/SLX4-ai-review.yaml	SLX4	Q8IY92	NCBITaxon:9606	Homo sapiens	33	R-HSA-5686475	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686475.md	SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization (SLX1A:SLX4 binds MUS81:EME1).
human	SLX4	genes/human/SLX4/SLX4-ai-review.yaml	SLX4	Q8IY92	NCBITaxon:9606	Homo sapiens	34	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization (Holliday-junction cleavage by SLX1A:SLX4:MUS81:EME1).
human	SLX4	genes/human/SLX4/SLX4-ai-review.yaml	SLX4	Q8IY92	NCBITaxon:9606	Homo sapiens	35	R-HSA-6785732	DNA nucleases bind monoubiquitinated ID2 complex	yes	reactome/R-HSA-6785732.md	DNA nucleases bind monoubiquitinated ID2 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization (DNA nucleases bind monoubiquitinated ID2 complex).
human	SLX4	genes/human/SLX4/SLX4-ai-review.yaml	SLX4	Q8IY92	NCBITaxon:9606	Homo sapiens	36	R-HSA-6785986	DNA nucleases unhook the interstrand crosslink (ICL)	yes	reactome/R-HSA-6785986.md	DNA nucleases unhook the interstrand crosslink (ICL)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization (DNA nucleases unhook the interstrand crosslink).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	162	R-HSA-2179276	SMURF2 monoubiquitinates SMAD3	yes	reactome/R-HSA-2179276.md	SMURF2 monoubiquitinates SMAD3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2179276).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	177	R-HSA-9731111	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3	yes	reactome/R-HSA-9731111.md	MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-9731111).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	202	R-HSA-6781764	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1	yes	reactome/R-HSA-6781764.md	USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-6781764).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	218	R-HSA-2176475	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9	yes	reactome/R-HSA-2176475.md	Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2176475).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	219	R-HSA-2176491	NEDD4L binds phosphorylated linker region of SMAD2/3	yes	reactome/R-HSA-2176491.md	NEDD4L binds phosphorylated linker region of SMAD2/3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2176491).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	220	R-HSA-2176502	NEDD4L ubiquitinates SMAD2/3	yes	reactome/R-HSA-2176502.md	NEDD4L ubiquitinates SMAD2/3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2176502).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	221	R-HSA-2176503	Degradation of SMAD2/3:SMAD4 complex	yes	reactome/R-HSA-2176503.md	Degradation of SMAD2/3:SMAD4 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2176503).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	222	R-HSA-2179274	SMURF2 binds SMAD3 phosphorylated in the linker region	yes	reactome/R-HSA-2179274.md	SMURF2 binds SMAD3 phosphorylated in the linker region	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2179274).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	223	R-HSA-1535903	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements	yes	reactome/R-HSA-1535903.md	Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-1535903).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	224	R-HSA-173481	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling	yes	reactome/R-HSA-173481.md	SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-173481).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	225	R-HSA-173488	The SMAD2/3:SMAD4 complex transfers to the nucleus	yes	reactome/R-HSA-173488.md	The SMAD2/3:SMAD4 complex transfers to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-173488).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	226	R-HSA-173545	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling	yes	reactome/R-HSA-173545.md	Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-173545).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	227	R-HSA-209055	PPM1A dephosphorylates nuclear SMAD2/3	yes	reactome/R-HSA-209055.md	PPM1A dephosphorylates nuclear SMAD2/3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-209055).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	228	R-HSA-2106579	WWTR1:SMAD translocates to the nucleus	yes	reactome/R-HSA-2106579.md	WWTR1:SMAD translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2106579).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	229	R-HSA-2127257	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2	yes	reactome/R-HSA-2127257.md	SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2127257).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	230	R-HSA-2186607	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer	yes	reactome/R-HSA-2186607.md	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2186607).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	231	R-HSA-2186643	MEN1 binds SMAD2/3:SMAD4 heterotrimer	yes	reactome/R-HSA-2186643.md	MEN1 binds SMAD2/3:SMAD4 heterotrimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2186643).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	232	R-HSA-2187309	SMAD2/3:SMAD4 heterotrimer binds SP1	yes	reactome/R-HSA-2187309.md	SMAD2/3:SMAD4 heterotrimer binds SP1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2187309).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	233	R-HSA-2187325	PARP1 ADP-ribosylates SMAD3 and SMAD4	yes	reactome/R-HSA-2187325.md	PARP1 ADP-ribosylates SMAD3 and SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2187325).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	234	R-HSA-2187330	PARP1 binds SMAD2/3:SMAD4 heterotrimer	yes	reactome/R-HSA-2187330.md	PARP1 binds SMAD2/3:SMAD4 heterotrimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2187330).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	235	R-HSA-2187388	PPM1A protein phosphatase binds phosphorylated SMAD2/3	yes	reactome/R-HSA-2187388.md	PPM1A protein phosphatase binds phosphorylated SMAD2/3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2187388).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	236	R-HSA-870449	TRIM33 monoubiquitinates SMAD4	yes	reactome/R-HSA-870449.md	TRIM33 monoubiquitinates SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-870449).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	237	R-HSA-870538	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus	yes	reactome/R-HSA-870538.md	TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-870538).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	238	R-HSA-8878143	RUNX3 binds SMAD3 and SMAD4	yes	reactome/R-HSA-8878143.md	RUNX3 binds SMAD3 and SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-8878143).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	239	R-HSA-8878178	The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter	yes	reactome/R-HSA-8878178.md	The complex of RUNX3, SMAD3 and SMAD4 binds the CDKN1A gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-8878178).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	240	R-HSA-8952226	RUNX3 binds the BCL2L11 (BIM) gene	yes	reactome/R-HSA-8952226.md	RUNX3 binds the BCL2L11 (BIM) gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-8952226).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	241	R-HSA-9617996	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4	yes	reactome/R-HSA-9617996.md	FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9617996).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	242	R-HSA-9618004	FOXO:SMAD complex binds CDKN1A gene promoter	yes	reactome/R-HSA-9618004.md	FOXO:SMAD complex binds CDKN1A gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9618004).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	243	R-HSA-9618021	FOXG1 binds FOXO:SMAD complexes	yes	reactome/R-HSA-9618021.md	FOXG1 binds FOXO:SMAD complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9618021).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	244	R-HSA-9733207	p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter	yes	reactome/R-HSA-9733207.md	p-2S-SMAD3:p-2S-SMAD3:SMAD4 forms a complex with SP1 and EP300 at the COL1A2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9733207).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	245	R-HSA-9733247	YBX1 binds COL1A2 gene promoter	yes	reactome/R-HSA-9733247.md	YBX1 binds COL1A2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9733247).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	246	R-HSA-9736959	WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter	yes	reactome/R-HSA-9736959.md	WWTR1:p-2S-SMAD2,3:SMAD4 binds SERPINE1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9736959).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	247	R-HSA-9736970	WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter	yes	reactome/R-HSA-9736970.md	WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9736970).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	248	R-HSA-9736979	p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter	yes	reactome/R-HSA-9736979.md	p-2S-SMAD2,3:SMAD4:SP1 binds CDKN2B gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9736979).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	249	R-HSA-9736984	p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter	yes	reactome/R-HSA-9736984.md	p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 binds MYC gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9736984).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	250	R-HSA-9736992	p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter	yes	reactome/R-HSA-9736992.md	p-2S-SMAD2,3:SMAD4 binds JUNB gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9736992).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	251	R-HSA-9737710	SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter	yes	reactome/R-HSA-9737710.md	SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9737710).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	252	R-HSA-9823952	EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene	yes	reactome/R-HSA-9823952.md	EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9823952).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	253	R-HSA-9823959	SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene	yes	reactome/R-HSA-9823959.md	SMAD2,3 and GATA6-AS1 lncRNA bind the GATA6 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-9823959).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	254	R-NUL-2186736	Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation	yes	reactome/R-NUL-2186736.md	Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-NUL-2186736).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	255	R-NUL-2186755	Ubiquitination of SKI/SKIL by Rnf111	yes	reactome/R-NUL-2186755.md	Ubiquitination of SKI/SKIL by Rnf111	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-NUL-2186755).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	256	R-NUL-9625758	FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter	yes	reactome/R-NUL-9625758.md	FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-NUL-9625758).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	257	R-HSA-3315483	Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4	yes	reactome/R-HSA-3315483.md	Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-3315483).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	258	R-HSA-2187395	Dephosphorylated SMAD2/3 translocates to the cytosol	yes	reactome/R-HSA-2187395.md	Dephosphorylated SMAD2/3 translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization (Reactome:R-HSA-2187395).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	259	R-HSA-1549526	Phosphorylation of SMAD2,3 by Activin:Activin Receptor	yes	reactome/R-HSA-1549526.md	Phosphorylation of SMAD2,3 by Activin:Activin Receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-1549526).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	260	R-HSA-170847	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4	yes	reactome/R-HSA-170847.md	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-170847).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	261	R-HSA-170850	Phosphorylated SMAD2/3 dissociates from TGFBR	yes	reactome/R-HSA-170850.md	Phosphorylated SMAD2/3 dissociates from TGFBR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-170850).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	262	R-HSA-170868	Activated type I receptor phosphorylates SMAD2/3 directly	yes	reactome/R-HSA-170868.md	Activated type I receptor phosphorylates SMAD2/3 directly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-170868).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	263	R-HSA-173488	The SMAD2/3:SMAD4 complex transfers to the nucleus	yes	reactome/R-HSA-173488.md	The SMAD2/3:SMAD4 complex transfers to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-173488).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	264	R-HSA-2031355	WWTR1 binds SMAD2/3:SMAD4 heterotrimer	yes	reactome/R-HSA-2031355.md	WWTR1 binds SMAD2/3:SMAD4 heterotrimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2031355).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	265	R-HSA-2106579	WWTR1:SMAD translocates to the nucleus	yes	reactome/R-HSA-2106579.md	WWTR1:SMAD translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2106579).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	266	R-HSA-2187355	PMEPA1 sequesters phosphorylated SMAD2/3	yes	reactome/R-HSA-2187355.md	PMEPA1 sequesters phosphorylated SMAD2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187355).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	267	R-HSA-2187401	MTMR4 dephosphorylates SMAD2/3	yes	reactome/R-HSA-2187401.md	MTMR4 dephosphorylates SMAD2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187401).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	268	R-HSA-2187405	MTMR4 binds phosphorylated SMAD2/3	yes	reactome/R-HSA-2187405.md	MTMR4 binds phosphorylated SMAD2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187405).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	269	R-HSA-3311014	SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3	yes	reactome/R-HSA-3311014.md	SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-3311014).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	270	R-HSA-9008928	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus	yes	reactome/R-HSA-9008928.md	IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-9008928).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	271	R-HSA-9009910	IL37(?-218) binds p-S423,S425-SMAD3	yes	reactome/R-HSA-9009910.md	IL37(?-218) binds p-S423,S425-SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-9009910).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	287	R-HSA-170835	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3	yes	reactome/R-HSA-170835.md	An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-170835).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	288	R-HSA-2187358	PMEPA1 sequesters unphosphorylated SMAD2/3	yes	reactome/R-HSA-2187358.md	PMEPA1 sequesters unphosphorylated SMAD2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187358).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	289	R-HSA-2187368	STUB1 (CHIP) ubiquitinates SMAD3	yes	reactome/R-HSA-2187368.md	STUB1 (CHIP) ubiquitinates SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187368).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	290	R-HSA-2187375	SMAD3 binds STUB1 (CHIP)	yes	reactome/R-HSA-2187375.md	SMAD3 binds STUB1 (CHIP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187375).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	291	R-HSA-2187382	Degradation of ubiquitinated SMAD3	yes	reactome/R-HSA-2187382.md	Degradation of ubiquitinated SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187382).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	292	R-HSA-2187395	Dephosphorylated SMAD2/3 translocates to the cytosol	yes	reactome/R-HSA-2187395.md	Dephosphorylated SMAD2/3 translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-2187395).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	293	R-HSA-3656523	An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants	yes	reactome/R-HSA-3656523.md	An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-3656523).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	294	R-HSA-9008692	IL37(?-218) binds SMAD3	yes	reactome/R-HSA-9008692.md	IL37(?-218) binds SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-9008692).
human	SMAD3	genes/human/SMAD3/SMAD3-ai-review.yaml	SMAD3	P84022	NCBITaxon:9606	Homo sapiens	295	R-HSA-9727922	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3	yes	reactome/R-HSA-9727922.md	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization (Reactome:R-HSA-9727922).
human	SMO	genes/human/SMO/SMO-ai-review.yaml	SMO	Q99835	NCBITaxon:9606	Homo sapiens	72	R-HSA-5633040	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer	yes	reactome/R-HSA-5633040.md	CSNK1A1 and ADRBK1 dissociate from p-SMO dimer	Homo sapiens	GO:0060170	ciliary membrane	TAS	located_in	CC	false		ACCEPT	SMO functions as a multi-pass receptor at the plasma membrane and undergoes activation-dependent accumulation in the membrane of the non-motile primary cilium. The ciliary membrane annotation is consistent with this established trafficking and signaling cycle.
human	SMO	genes/human/SMO/SMO-ai-review.yaml	SMO	Q99835	NCBITaxon:9606	Homo sapiens	73	R-HSA-5632668	SMO translocates to the cilium	yes	reactome/R-HSA-5632668.md	SMO translocates to the cilium	Homo sapiens	GO:0060170	ciliary membrane	TAS	located_in	CC	false		ACCEPT	SMO functions as a multi-pass receptor at the plasma membrane and undergoes activation-dependent accumulation in the membrane of the non-motile primary cilium. The ciliary membrane annotation is consistent with this established trafficking and signaling cycle.
human	SMO	genes/human/SMO/SMO-ai-review.yaml	SMO	Q99835	NCBITaxon:9606	Homo sapiens	74	R-HSA-5610763	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal	yes	reactome/R-HSA-5610763.md	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal	Homo sapiens	GO:0097542	ciliary tip	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The ciliary tip annotation is compatible with a context-specific localization, trafficking state, or downstream role of SMO, but it does not define SMO's core receptor/transducer activity.
human	SMO	genes/human/SMO/SMO-ai-review.yaml	SMO	Q99835	NCBITaxon:9606	Homo sapiens	75	R-HSA-5610763	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal	yes	reactome/R-HSA-5610763.md	PTCH1 inhibits accumulation of SMO in the primary cilium in the absence of Hh signal	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The endocytic vesicle membrane annotation is compatible with a context-specific localization, trafficking state, or downstream role of SMO, but it does not define SMO's core receptor/transducer activity.
human	SMO	genes/human/SMO/SMO-ai-review.yaml	SMO	Q99835	NCBITaxon:9606	Homo sapiens	76	R-HSA-5632668	SMO translocates to the cilium	yes	reactome/R-HSA-5632668.md	SMO translocates to the cilium	Homo sapiens	GO:0030666	endocytic vesicle membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The endocytic vesicle membrane annotation is compatible with a context-specific localization, trafficking state, or downstream role of SMO, but it does not define SMO's core receptor/transducer activity.
human	SMOX	genes/human/SMOX/SMOX-ai-review.yaml	SMOX	Q9NWM0	NCBITaxon:9606	Homo sapiens	11	R-HSA-351200	Interconversion of polyamines	yes	reactome/R-HSA-351200.md	Interconversion of polyamines	Homo sapiens	GO:0006596	polyamine biosynthetic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	TAS annotation propagated from the Reactome Interconversion of polyamines pathway, which groups both biosynthetic aminopropyltransferase steps and catabolic oxidase steps. SMOX is a catabolic enzyme that degrades spermine to spermidine; it does not biosynthesize polyamines. Its role in the interconversion pathway recycles spermine to spermidine (a catabolic / back-conversion event), so polyamine biosynthetic process mis-frames the enzyme's direction and is an over-annotation arising from the mixed-content Reactome pathway.
human	SMOX	genes/human/SMOX/SMOX-ai-review.yaml	SMOX	Q9NWM0	NCBITaxon:9606	Homo sapiens	12	R-HSA-141334	PAOs oxidise polyamines to amines	yes	reactome/R-HSA-141334.md	PAOs oxidise polyamines to amines	Homo sapiens	GO:0006805	xenobiotic metabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	TAS annotation from the Reactome PAOs oxidise polyamines to amines reaction, whose summary notes that PAOs act on endogenous polyamines as well as some xenobiotics. SMOX's characterized, physiological substrate is endogenous spermine; there is no experimental evidence that SMOX metabolizes xenobiotics. This is a family-level generalization that does not reflect the specific biology of SMOX.
human	SMOX	genes/human/SMOX/SMOX-ai-review.yaml	SMOX	Q9NWM0	NCBITaxon:9606	Homo sapiens	14	R-HSA-141341	SMOX-3 oxidises SPN to SPM	yes	reactome/R-HSA-141341.md	SMOX-3 oxidises SPN to SPM	Homo sapiens	GO:0052901	spermine oxidase activity	TAS	enables	MF	false		ACCEPT	TAS annotation from the Reactome reaction SMOX-3 oxidises SPN to SPM (spermine oxidase flavoenzyme catalysing oxidation of spermine to spermidine). Correct specific molecular function, corroborating the experimental spermine oxidase activity annotations.
human	SMOX	genes/human/SMOX/SMOX-ai-review.yaml	SMOX	Q9NWM0	NCBITaxon:9606	Homo sapiens	21	R-HSA-141341	SMOX-3 oxidises SPN to SPM	yes	reactome/R-HSA-141341.md	SMOX-3 oxidises SPN to SPM	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS cytosol location from the Reactome SMOX oxidation reaction. Consistent with the direct HPA immunofluorescence cytosol annotation. Core location for the soluble enzyme.
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	23	R-HSA-9769740	Coagulation pathway	yes	reactome/R-HSA-9769740.md	Coagulation pathway	Homo sapiens	GO:0007596	blood coagulation	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome pathway annotation placing SMPD1 in a coagulation-pathway context. Not an established core or well-supported specific role for ASM.
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	24	R-HSA-9840310	Glycosphingolipid catabolism	yes	reactome/R-HSA-9840310.md	Glycosphingolipid catabolism	Homo sapiens	GO:0046479	glycosphingolipid catabolic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome places SMPD1 within a broad glycosphingolipid-catabolism pathway. Sphingomyelin is a phosphosphingolipid, not a glycosphingolipid, so this is broader/less precise than the enzyme's actual reaction.
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	25	R-HSA-1605797	SMPD1 hydrolyzes SPHM	yes	reactome/R-HSA-1605797.md	SMPD1 hydrolyzes SPHM	Homo sapiens	GO:0004767	sphingomyelin phosphodiesterase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""SMPD1 hydrolyzes SPHM"" asserts the core sphingomyelin phosphodiesterase activity. Correct and consistent with all other evidence."
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	26	R-HSA-9769742	SMPD1 converts sphingomyelin to ceramide	yes	reactome/R-HSA-9769742.md	SMPD1 converts sphingomyelin to ceramide	Homo sapiens	GO:0004767	sphingomyelin phosphodiesterase activity	TAS	enables	MF	false		ACCEPT	"Reactome reaction ""SMPD1 converts sphingomyelin to ceramide"" asserts the core MF. Duplicate of the other Reactome/experimental MF annotations."
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	42	R-HSA-1605797	SMPD1 hydrolyzes SPHM	yes	reactome/R-HSA-1605797.md	SMPD1 hydrolyzes SPHM	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		ACCEPT	ASM acts in the lysosomal lumen, the acidic compartment where it hydrolyzes sphingomyelin. A precise refinement of the lysosomal localization. Core CC.
human	SMPD1	genes/human/SMPD1/SMPD1-ai-review.yaml	SMPD1	P17405	NCBITaxon:9606	Homo sapiens	48	R-HSA-9769742	SMPD1 converts sphingomyelin to ceramide	yes	reactome/R-HSA-9769742.md	SMPD1 converts sphingomyelin to ceramide	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	ASM can be recruited to the plasma membrane (outer leaflet) upon stress or infection, where the secreted/surface form generates ceramide. Non-core.
human	SMPD2	genes/human/SMPD2/SMPD2-ai-review.yaml	SMPD2	O60906	NCBITaxon:9606	Homo sapiens	29	R-HSA-1606273	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)	yes	reactome/R-HSA-1606273.md	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the supported cell-surface membrane context.
human	SMPD2	genes/human/SMPD2/SMPD2-ai-review.yaml	SMPD2	O60906	NCBITaxon:9606	Homo sapiens	30	R-HSA-5626981	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	yes	reactome/R-HSA-5626981.md	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the supported cell-surface membrane context.
human	SMPD3	genes/human/SMPD3/SMPD3-ai-review.yaml	SMPD3	Q9NY59	NCBITaxon:9606	Homo sapiens	28	R-HSA-1606273	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)	yes	reactome/R-HSA-1606273.md	SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted plasma-membrane localization for the reaction ""SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)"". Consistent with the experimentally confirmed plasma-membrane location and core function of nSMase2."
human	SMPD3	genes/human/SMPD3/SMPD3-ai-review.yaml	SMPD3	Q9NY59	NCBITaxon:9606	Homo sapiens	29	R-HSA-5626981	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	yes	reactome/R-HSA-5626981.md	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome-asserted plasma-membrane localization within the TNF-α:TNFR1:NSMAF:GNB2L1 complex that associates with SMPD2/3, the site of TNF-triggered ceramide production. Consistent with the plasma-membrane location; core-compatible.
human	SMPD4	genes/human/SMPD4/SMPD4-ai-review.yaml	SMPD4	Q9NXE4	NCBITaxon:9606	Homo sapiens	11	R-HSA-1606288	SMPD4 hydrolyzes sphingomyelin (ER membrane)	yes	reactome/R-HSA-1606288.md	SMPD4 hydrolyzes sphingomyelin (ER membrane)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing SMPD4 at the ER membrane, where it hydrolyses sphingomyelin. Consistent with the experimental localization. Accept.
human	SMS	genes/human/SMS/SMS-ai-review.yaml	SMS	P52788	NCBITaxon:9606	Homo sapiens	7	R-HSA-351202	Metabolism of polyamines	yes	reactome/R-HSA-351202.md	Metabolism of polyamines	Homo sapiens	GO:0006595	polyamine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation to polyamine metabolic process via the ""Metabolism of polyamines"" pathway. Correct but a broad parent term; the specific spermine biosynthetic process is separately annotated. Retained as non-core."
human	SMS	genes/human/SMS/SMS-ai-review.yaml	SMS	P52788	NCBITaxon:9606	Homo sapiens	10	R-HSA-351210	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine	yes	reactome/R-HSA-351210.md	dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation to cytosol, from the curated spermine-synthesis reaction. Consistent with a soluble cytosolic enzyme and with the ARBA cytosol annotation. Correct core location.
human	SOCS1	genes/human/SOCS1/SOCS1-ai-review.yaml	SOCS1	O15524	NCBITaxon:9606	Homo sapiens	26	R-HSA-6785860	Expression of SOCS1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome). SOCS1 acts on receptor-associated JAKs in the cytoplasm; this is its primary functional compartment.
human	SOCS1	genes/human/SOCS1/SOCS1-ai-review.yaml	SOCS1	O15524	NCBITaxon:9606	Homo sapiens	27	R-HSA-877269	SOCS-1 and SOCS-3 binds to p-JAK2	yes	reactome/R-HSA-877269.md	SOCS-1 and SOCS-3 binds to p-JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome), from the SOCS-1/SOCS-3 binding to p-JAK2 event. Consistent with the core cytoplasmic JAK-regulation role.
human	SOCS1	genes/human/SOCS1/SOCS1-ai-review.yaml	SOCS1	O15524	NCBITaxon:9606	Homo sapiens	28	R-HSA-8983011	Expression of STAT5 upregulated genes	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome). Redundant with other cytosol annotations.
human	SOCS1	genes/human/SOCS1/SOCS1-ai-review.yaml	SOCS1	O15524	NCBITaxon:9606	Homo sapiens	29	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer complex	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome), from the SOCS1/3 CSF3R ubiquitination event. Consistent with the SOCS-box E3 adaptor activity occurring in the cytoplasm.
human	SOCS1	genes/human/SOCS1/SOCS1-ai-review.yaml	SOCS1	O15524	NCBITaxon:9606	Homo sapiens	30	R-NUL-1169195	SOCS binding to Ghr	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization (Reactome). Redundant cytosol annotation.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	19	R-HSA-6785860	Expression of SOCS1	no				GO:0005829	cytosol	TAS	is_active_in	CC	false		KEEP_AS_NON_CORE	SOCS3 acts in the cytosol and at the cytoplasmic face of receptor complexes. Cytosolic localization is correct but is a general location, not a core function.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	24	R-HSA-1112755	SOCS3 binds IL6ST	yes	reactome/R-HSA-1112755.md	SOCS3 binds IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (SOCS3 binds IL6ST). Correct location annotation.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	25	R-HSA-6790041	Expression of STAT3-upregulated cytosolic proteins	yes	reactome/R-HSA-6790041.md	Expression of STAT3-upregulated cytosolic proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization annotation. Correct but redundant.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	26	R-HSA-877269	SOCS-1 and SOCS-3 binds to p-JAK2	yes	reactome/R-HSA-877269.md	SOCS-1 and SOCS-3 binds to p-JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (SOCS-1/SOCS-3 bind p-JAK2). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	27	R-HSA-8848110	SOCS3 binds activated PTK6	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (SOCS3 binds activated PTK6). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	28	R-HSA-8848178	STAT3 stimulates SOCS3 expression	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (STAT3 stimulates SOCS3 expression). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	29	R-HSA-8952039	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952039.md	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (CRL5/neddylation pathway). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	30	R-HSA-8952044	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952044.md	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (CRL5/neddylation pathway). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	31	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (CAND1/CRL regulation). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	32	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (COMMD/CAND1/CRL regulation). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	33	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (COP9 signalosome deneddylation). Correct location.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	34	R-HSA-9705738	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	yes	reactome/R-HSA-9705738.md	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (SOCS1,3 ubiquitinates CSF3R within a CUL5/ELOB/ELOC/RNF7 complex). Correct location and consistent with SOCS3 E3-ligase function.
human	SOCS3	genes/human/SOCS3/SOCS3-ai-review.yaml	SOCS3	O14543	NCBITaxon:9606	Homo sapiens	35	R-NUL-1169195	SOCS binding to Ghr	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosol localization (SOCS binding to growth hormone receptor). Correct location.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	19	R-HSA-6785821	SOCS5,(SOCS1) bind IL4RA	yes	reactome/R-HSA-6785821.md	SOCS5,(SOCS1) bind IL4RA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SOCS5 localizes to the cytosol where it functions in regulating cytokine and growth factor receptor signaling. Multiple Reactome pathways support cytosolic localization.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	20	R-HSA-8952039	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952039.md	NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation based on different Reactome pathway (neddylation of CRL5 complex). Supports same localization.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	21	R-HSA-8952044	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	yes	reactome/R-HSA-8952044.md	AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation based on neddylation pathway. Supports same localization.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	22	R-HSA-8955241	CAND1 binds cytosolic CRL E3 ubiquitin ligases	yes	reactome/R-HSA-8955241.md	CAND1 binds cytosolic CRL E3 ubiquitin ligases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation. All Reactome pathways consistently place SOCS5 in cytosol.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	23	R-HSA-8955289	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8955289.md	COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway.
human	SOCS5	genes/human/SOCS5/SOCS5-ai-review.yaml	SOCS5	O75159	NCBITaxon:9606	Homo sapiens	24	R-HSA-8956040	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	yes	reactome/R-HSA-8956040.md	COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome deneddylation pathway.
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	87	R-HSA-3777112	Reactome pathway annotation	yes	reactome/R-HSA-3777112.md	SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Mitochondrial IMS (TAS, Reactome) dismutation.
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	88	R-HSA-8950771	Reactome pathway annotation	yes	reactome/R-HSA-8950771.md	Expression of SOD1	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Mitochondrial IMS (TAS, Reactome) detoxification of ROS.
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	89	R-HSA-3299691	Reactome pathway annotation	yes	reactome/R-HSA-3299691.md	SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	90	R-HSA-3299753	Reactome pathway annotation	yes	reactome/R-HSA-3299753.md	CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	99	R-HSA-482772	Reactome pathway annotation	yes	reactome/R-HSA-482772.md	Release of platelet cytosolic components	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Extracellular region (TAS, Reactome).
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	100	R-HSA-3697860	Reactome pathway annotation	yes	reactome/R-HSA-3697860.md	SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	101	R-HSA-482772	Reactome pathway annotation	yes	reactome/R-HSA-482772.md	Release of platelet cytosolic components	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	SOD1	genes/human/SOD1/SOD1-ai-review.yaml	SOD1	P00441	NCBITaxon:9606	Homo sapiens	102	R-HSA-8951723	Reactome pathway annotation	yes	reactome/R-HSA-8951723.md	2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol (TAS, Reactome).
human	SORL1	genes/human/SORL1/SORL1-ai-review.yaml	SORL1	Q92673	NCBITaxon:9606	Homo sapiens	125	R-HSA-8871506	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	yes	reactome/R-HSA-8871506.md	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	As a single-pass type I membrane protein, SorLA sits in the Golgi/TGN membrane where it engages adaptors (GGA, AP-1) and retains cargo such as APP.
human	SORL1	genes/human/SORL1/SORL1-ai-review.yaml	SORL1	Q92673	NCBITaxon:9606	Homo sapiens	126	R-HSA-8871494	SORL1 binds APP(18-770)	yes	reactome/R-HSA-8871494.md	SORL1 binds APP(18-770)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	The transmembrane receptor is embedded in the endosomal limiting membrane, where its cytosolic tail binds retromer/GGA adaptors for sorting.
human	SORL1	genes/human/SORL1/SORL1-ai-review.yaml	SORL1	Q92673	NCBITaxon:9606	Homo sapiens	127	R-HSA-8871506	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	yes	reactome/R-HSA-8871506.md	SORL1 transports APP(18-770) from endosome lumen to Golgi lumen	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	The transmembrane receptor is embedded in the endosomal limiting membrane, where its cytosolic tail binds retromer/GGA adaptors for sorting.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	10	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	11	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	12	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	13	R-HSA-210977	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	14	R-HSA-2424477	SOS mediated nucleotide exchange of RAS (SHC)	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	15	R-HSA-392054	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	16	R-HSA-9607304	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	17	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	18	R-HSA-9672170	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	19	R-HSA-9695853	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	20	R-HSA-9703441	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005085	guanyl-nucleotide exchange factor activity	TAS	enables	MF	false		ACCEPT	SOS1 is a guanyl-nucleotide exchange factor that catalyzes GDP release from RAS (H-, N-, K-RAS), the core molecular function of the protein.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	81	R-HSA-109813	GRB2-1 binds SOS1	yes	reactome/R-HSA-109813.md	GRB2-1 binds SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	82	R-HSA-109822	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1	yes	reactome/R-HSA-109822.md	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	83	R-HSA-109823	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2	yes	reactome/R-HSA-109823.md	MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	84	R-HSA-1225950	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	yes	reactome/R-HSA-1225950.md	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	85	R-HSA-1225951	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225951.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	86	R-HSA-1225957	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	yes	reactome/R-HSA-1225957.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	87	R-HSA-1225961	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	yes	reactome/R-HSA-1225961.md	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	88	R-HSA-1250380	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers	yes	reactome/R-HSA-1250380.md	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	89	R-HSA-1250383	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	yes	reactome/R-HSA-1250383.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	90	R-HSA-1306969	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306969.md	GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	91	R-HSA-1306972	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	yes	reactome/R-HSA-1306972.md	RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	92	R-HSA-1433471	Activation of RAS by p-KIT bound SOS1	yes	reactome/R-HSA-1433471.md	Activation of RAS by p-KIT bound SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	93	R-HSA-177936	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	yes	reactome/R-HSA-177936.md	GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	94	R-HSA-177938	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	yes	reactome/R-HSA-177938.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	95	R-HSA-177943	GRB2:SOS1 complex binds to EGF:EGFR complex	yes	reactome/R-HSA-177943.md	GRB2:SOS1 complex binds to EGF:EGFR complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	96	R-HSA-177945	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	yes	reactome/R-HSA-177945.md	SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	97	R-HSA-186826	GRB2:SOS1 complex binds to the active receptor	yes	reactome/R-HSA-186826.md	GRB2:SOS1 complex binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	98	R-HSA-186834	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	yes	reactome/R-HSA-186834.md	SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	99	R-HSA-205039	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	yes	reactome/R-HSA-205039.md	p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	100	R-HSA-205244	Recruitment of CBL to KIT	yes	reactome/R-HSA-205244.md	Recruitment of CBL to KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	101	R-HSA-205286	GRB2:SOS interacts with p-KIT	yes	reactome/R-HSA-205286.md	GRB2:SOS interacts with p-KIT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	102	R-HSA-210974	Interaction of SOS-1 to Tie2 bound Grb2	yes	reactome/R-HSA-210974.md	Interaction of SOS-1 to Tie2 bound Grb2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	103	R-HSA-210977	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	yes	reactome/R-HSA-210977.md	Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	104	R-HSA-2179407	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	yes	reactome/R-HSA-2179407.md	SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	105	R-HSA-2179415	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	yes	reactome/R-HSA-2179415.md	GRB2:SOS1 binds to HBEGF:p-Y-EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	106	R-HSA-2396561	Recruitment of GADS:SLP-76 to p-5Y-LAT	yes	reactome/R-HSA-2396561.md	Recruitment of GADS:SLP-76 to p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	107	R-HSA-2396594	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2396594.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	108	R-HSA-2396599	Recruitment of GRB2:SOS to p-5Y-LAT	yes	reactome/R-HSA-2396599.md	Recruitment of GRB2:SOS to p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	109	R-HSA-2396606	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	yes	reactome/R-HSA-2396606.md	Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	110	R-HSA-2424476	Activation of RAC1 by VAV2/3	yes	reactome/R-HSA-2424476.md	Activation of RAC1 by VAV2/3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	111	R-HSA-2424477	SOS mediated nucleotide exchange of RAS (SHC)	yes	reactome/R-HSA-2424477.md	SOS mediated nucleotide exchange of RAS (SHC)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	112	R-HSA-2424481	Recruitment of VAV and BTK to p-SLP-76	yes	reactome/R-HSA-2424481.md	Recruitment of VAV and BTK to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	113	R-HSA-2424484	Phosphorylation of BTK by p-SYK	yes	reactome/R-HSA-2424484.md	Phosphorylation of BTK by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	114	R-HSA-2424485	Release of p-PLCG1	yes	reactome/R-HSA-2424485.md	Release of p-PLCG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	115	R-HSA-2424486	Phosphorylation and activation of VAV2/VAV3 by SYK	yes	reactome/R-HSA-2424486.md	Phosphorylation and activation of VAV2/VAV3 by SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	116	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	yes	reactome/R-HSA-2424487.md	Phosphorylation of PLC-gamma by p-BTK/p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	117	R-HSA-2730833	Phosphorylation of TEC kinases by p-SYK	yes	reactome/R-HSA-2730833.md	Phosphorylation of TEC kinases by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	118	R-HSA-2730837	Recruitment of GRB2:SOS to p-10Y-NTAL	yes	reactome/R-HSA-2730837.md	Recruitment of GRB2:SOS to p-10Y-NTAL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	119	R-HSA-2730840	Activation of RAC1 by VAV	yes	reactome/R-HSA-2730840.md	Activation of RAC1 by VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	120	R-HSA-2730841	Phosphorylation and activation of VAV	yes	reactome/R-HSA-2730841.md	Phosphorylation and activation of VAV	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	121	R-HSA-2730842	PI3K associates with phosphorylated GAB2	yes	reactome/R-HSA-2730842.md	PI3K associates with phosphorylated GAB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	122	R-HSA-2730844	Interaction of GRB2:SOS complex with p-SHC1	yes	reactome/R-HSA-2730844.md	Interaction of GRB2:SOS complex with p-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	123	R-HSA-2730847	Hydrolysis of PIP2 by PLCG	yes	reactome/R-HSA-2730847.md	Hydrolysis of PIP2 by PLCG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	124	R-HSA-2730851	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2730851.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	125	R-HSA-2730856	Autophosphorylation of PAK	yes	reactome/R-HSA-2730856.md	Autophosphorylation of PAK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	126	R-HSA-2730858	Autophosphorylation of BTK/ITK	yes	reactome/R-HSA-2730858.md	Autophosphorylation of BTK/ITK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	127	R-HSA-2730870	Phosphorylation of PIP2 to PIP3 by PI3K	yes	reactome/R-HSA-2730870.md	Phosphorylation of PIP2 to PIP3 by PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	128	R-HSA-2730889	Recruitment of PAK to the membrane by binding active RAC1	yes	reactome/R-HSA-2730889.md	Recruitment of PAK to the membrane by binding active RAC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	129	R-HSA-2730892	Recruitment of VAV to p-SLP-76	yes	reactome/R-HSA-2730892.md	Recruitment of VAV to p-SLP-76	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	130	R-HSA-354165	Interaction of SOS with GRB2 bound to FADK1	yes	reactome/R-HSA-354165.md	Interaction of SOS with GRB2 bound to FADK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	131	R-HSA-392053	SOS binds Grb2 bound to pFAK:NCAM1	yes	reactome/R-HSA-392053.md	SOS binds Grb2 bound to pFAK:NCAM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	132	R-HSA-392054	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	yes	reactome/R-HSA-392054.md	NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	133	R-HSA-419166	GEFs activate RhoA,B,C	yes	reactome/R-HSA-419166.md	GEFs activate RhoA,B,C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	134	R-HSA-453111	Phosphorylated SHC recruits GRB2:SOS1	yes	reactome/R-HSA-453111.md	Phosphorylated SHC recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	135	R-HSA-5637770	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	yes	reactome/R-HSA-5637770.md	Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	136	R-HSA-5637798	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	yes	reactome/R-HSA-5637798.md	Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	137	R-HSA-5637806	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	yes	reactome/R-HSA-5637806.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	138	R-HSA-5637808	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	yes	reactome/R-HSA-5637808.md	SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	139	R-HSA-5654392	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654392.md	Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	140	R-HSA-5654402	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654402.md	Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	141	R-HSA-5654406	Activated FGFR2:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654406.md	Activated FGFR2:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	142	R-HSA-5654413	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654413.md	Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	143	R-HSA-5654416	Activated FGFR3:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654416.md	Activated FGFR3:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	144	R-HSA-5654423	Activated FGFR4:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654423.md	Activated FGFR4:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	145	R-HSA-5654426	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654426.md	Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	146	R-HSA-5654586	Activated FGFR1:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654586.md	Activated FGFR1:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	147	R-HSA-5654597	Activated FGFR1:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654597.md	Activated FGFR1:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	148	R-HSA-5654600	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654600.md	Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	149	R-HSA-5654615	Activated FGFR2:pFRS binds GRB2:SOS1	yes	reactome/R-HSA-5654615.md	Activated FGFR2:pFRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	150	R-HSA-5654618	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654618.md	Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	151	R-HSA-5654646	Activated FGFR3:p-SHC1 binds GRB2:SOS1	yes	reactome/R-HSA-5654646.md	Activated FGFR3:p-SHC1 binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	152	R-HSA-5654647	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654647.md	Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	153	R-HSA-5654663	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5654663.md	Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	154	R-HSA-5654664	Activated FGFR4:p-FRS binds GRB2:SOS1	yes	reactome/R-HSA-5654664.md	Activated FGFR4:p-FRS binds GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	155	R-HSA-5655233	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655233.md	Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	156	R-HSA-5655241	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655241.md	Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	157	R-HSA-5655266	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655266.md	Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	158	R-HSA-5655277	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655277.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	159	R-HSA-5655295	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655295.md	Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	160	R-HSA-5655326	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655326.md	Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	161	R-HSA-5655347	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	yes	reactome/R-HSA-5655347.md	Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	162	R-HSA-5655348	Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1	yes	reactome/R-HSA-5655348.md	Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	163	R-HSA-5672965	RAS GEFs promote RAS nucleotide exchange	yes	reactome/R-HSA-5672965.md	RAS GEFs promote RAS nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	164	R-HSA-5685366	GRB2-1:SOS1 binds p-Y-SHC	yes	reactome/R-HSA-5685366.md	GRB2-1:SOS1 binds p-Y-SHC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	165	R-HSA-5686073	GRB2-1:SOS1 binds p-3Y-SHC1	yes	reactome/R-HSA-5686073.md	GRB2-1:SOS1 binds p-3Y-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	166	R-HSA-5686074	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates	yes	reactome/R-HSA-5686074.md	GRB2-1:p-4S-SOS1:p-Y427-SHC1 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	167	R-HSA-5686315	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates	yes	reactome/R-HSA-5686315.md	GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	168	R-HSA-74736	GRB2-1:SOS1 binds p-IRS1,p-IRS2	yes	reactome/R-HSA-74736.md	GRB2-1:SOS1 binds p-IRS1,p-IRS2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	169	R-HSA-74746	GRB2-1:SOS1 binds p-Y427-SHC1	yes	reactome/R-HSA-74746.md	GRB2-1:SOS1 binds p-Y427-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	170	R-HSA-8851804	Activated MET recruits GRB2-1:SOS1	yes	reactome/R-HSA-8851804.md	Activated MET recruits GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	171	R-HSA-8851827	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	yes	reactome/R-HSA-8851827.md	RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	172	R-HSA-8851859	Activated MET binds RANBP9 and SOS1	yes	reactome/R-HSA-8851859.md	Activated MET binds RANBP9 and SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	173	R-HSA-8851877	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	yes	reactome/R-HSA-8851877.md	RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	174	R-HSA-8851899	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	yes	reactome/R-HSA-8851899.md	RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	175	R-HSA-8851900	SHC1-2 bound to MET recruits GRB2:SOS1	yes	reactome/R-HSA-8851900.md	SHC1-2 bound to MET recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	176	R-HSA-8853734	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1	yes	reactome/R-HSA-8853734.md	2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	177	R-HSA-8854899	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1	yes	reactome/R-HSA-8854899.md	2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	178	R-HSA-9032073	NTRK2-phosphorylated FRS2 binds GRB2	yes	reactome/R-HSA-9032073.md	NTRK2-phosphorylated FRS2 binds GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	179	R-HSA-9607301	Active FLT3:GRB2 binds SOS1	yes	reactome/R-HSA-9607301.md	Active FLT3:GRB2 binds SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	180	R-HSA-9607304	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	yes	reactome/R-HSA-9607304.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	181	R-HSA-9634402	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer	yes	reactome/R-HSA-9634402.md	Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	182	R-HSA-9634418	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	yes	reactome/R-HSA-9634418.md	RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	183	R-HSA-9664983	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9664983.md	Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	184	R-HSA-9664991	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	yes	reactome/R-HSA-9664991.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	185	R-HSA-9665000	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665000.md	Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	186	R-HSA-9665009	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	yes	reactome/R-HSA-9665009.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	187	R-HSA-9665404	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	yes	reactome/R-HSA-9665404.md	RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	188	R-HSA-9665408	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	yes	reactome/R-HSA-9665408.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	189	R-HSA-9665409	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	yes	reactome/R-HSA-9665409.md	GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	190	R-HSA-9665413	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665413.md	Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	191	R-HSA-9665698	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	yes	reactome/R-HSA-9665698.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	192	R-HSA-9665699	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	yes	reactome/R-HSA-9665699.md	Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	193	R-HSA-9665700	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	yes	reactome/R-HSA-9665700.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	194	R-HSA-9665707	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	yes	reactome/R-HSA-9665707.md	RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	195	R-HSA-9670428	KIT mutants bind GRB2-SOS	yes	reactome/R-HSA-9670428.md	KIT mutants bind GRB2-SOS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	196	R-HSA-9670436	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	yes	reactome/R-HSA-9670436.md	p-KIT mutants:GRB2:SOS catalyzes nucleotide exchange on RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	197	R-HSA-9672158	GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672158.md	GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	198	R-HSA-9672163	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672163.md	SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	199	R-HSA-9672164	GRB2:SOS1 complex binds to mutant PDGFR receptor	yes	reactome/R-HSA-9672164.md	GRB2:SOS1 complex binds to mutant PDGFR receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	200	R-HSA-9672170	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	yes	reactome/R-HSA-9672170.md	SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	201	R-HSA-9695845	FLT3 mutant dimers:GRB2 bind SOS1	yes	reactome/R-HSA-9695845.md	FLT3 mutant dimers:GRB2 bind SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	202	R-HSA-9695853	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	yes	reactome/R-HSA-9695853.md	FLT3 mutants:GRB2:SOS1-mediated nucleotide exchange on RAS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	203	R-HSA-9703430	FLT3 fusions:GRB2 bind SOS1	yes	reactome/R-HSA-9703430.md	FLT3 fusions:GRB2 bind SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	204	R-HSA-9703441	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	yes	reactome/R-HSA-9703441.md	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	205	R-HSA-983703	p-6Y-SYK phosphorylates BLNK (SLP65)	yes	reactome/R-HSA-983703.md	p-6Y-SYK phosphorylates BLNK (SLP65)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	206	R-HSA-9842669	Active LTK recruits GRB2:SOS1	yes	reactome/R-HSA-9842669.md	Active LTK recruits GRB2:SOS1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	208	R-HSA-1112666	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	yes	reactome/R-HSA-1112666.md	BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	209	R-HSA-9606151	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	yes	reactome/R-HSA-9606151.md	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	210	R-HSA-9691421	BTK binds BTK inhibitors	yes	reactome/R-HSA-9691421.md	BTK binds BTK inhibitors	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	211	R-HSA-983703	p-6Y-SYK phosphorylates BLNK (SLP65)	yes	reactome/R-HSA-983703.md	p-6Y-SYK phosphorylates BLNK (SLP65)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane, the site where SOS1 catalyzes RAS nucleotide exchange.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	215	R-HSA-177929	Signaling by EGFR	yes	reactome/R-HSA-177929.md	Signaling by EGFR	Homo sapiens	GO:0007173	epidermal growth factor receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	Epidermal growth factor receptor signaling pathway.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	222	R-HSA-422475	Axon guidance	yes	reactome/R-HSA-422475.md	Axon guidance	Homo sapiens	GO:0007411	axon guidance	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Axon guidance (Reactome pathway context).
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	227	R-HSA-9607240	FLT3 Signaling	yes	reactome/R-HSA-9607240.md	FLT3 Signaling	Homo sapiens	GO:0019221	cytokine-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Cytokine-mediated signaling pathway.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	230	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	yes	reactome/R-HSA-2454202.md	Fc epsilon receptor (FCERI) signaling	Homo sapiens	GO:0038095	Fc-epsilon receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Fc-epsilon receptor signaling pathway.
human	SOS1	genes/human/SOS1/SOS1-ai-review.yaml	SOS1	Q07889	NCBITaxon:9606	Homo sapiens	241	R-HSA-202733	Cell surface interactions at the vascular wall	yes	reactome/R-HSA-202733.md	Cell surface interactions at the vascular wall	Homo sapiens	GO:0050900	leukocyte migration	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Leukocyte migration (Reactome pathway context).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	71	R-HSA-1112609	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS evidence from Reactome pathway annotation (multiple Reactome entries).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	72	R-HSA-2972948	POU5F1 (OCT4), SOX2, NANOG bind GSC promoter	yes	reactome/R-HSA-2972948.md	POU5F1 (OCT4), SOX2, NANOG bind the GSC promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (OCT4, SOX2, NANOG bind GSC promoter).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	73	R-HSA-2972949	POU5F1 (OCT4), SOX2, NANOG bind EOMES promoter	yes	reactome/R-HSA-2972949.md	POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (OCT4, SOX2, NANOG bind EOMES promoter).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	74	R-HSA-2972956	POU5F1 (OCT4), SOX2, NANOG bind STAT3 promoter	yes	reactome/R-HSA-2972956.md	POU5F1 (OCT4), SOX2, NANOG bind the STAT3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (STAT3 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	75	R-HSA-2972960	POU5F1 (OCT4), SOX2, NANOG bind FGF2 promoter	yes	reactome/R-HSA-2972960.md	POU5F1 (OCT4), SOX2, NANOG bind the FGF2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (FGF2 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	76	R-HSA-2972962	POU5F1 (OCT4), SOX2, NANOG bind TDGF1 promoter	yes	reactome/R-HSA-2972962.md	POU5F1 (OCT4), SOX2, NANOG bind the TDGF1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (TDGF1 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	77	R-HSA-2972964	POU5F1 (OCT4), SOX2, NANOG bind FOXD3 promoter	yes	reactome/R-HSA-2972964.md	POU5F1 (OCT4), SOX2, NANOG bind the FOXD3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (FOXD3 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	78	R-HSA-2972965	POU5F1 (OCT4), SOX2, NANOG bind TSC22D1 promoter	yes	reactome/R-HSA-2972965.md	POU5F1 (OCT4), SOX2, NANOG bind the TSC22D1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (TSC22D1 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	79	R-HSA-2972966	POU5F1 (OCT4), SOX2, NANOG bind HHEX promoter	yes	reactome/R-HSA-2972966.md	POU5F1 (OCT4), SOX2, NANOG bind the HHEX promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (HHEX promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	80	R-HSA-2972967	POU5F1 (OCT4), SOX2, NANOG bind EPHA1 promoter	yes	reactome/R-HSA-2972967.md	POU5F1 (OCT4), SOX2, NANOG bind the EPHA1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (EPHA1 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	81	R-HSA-2972975	POU5F1 (OCT4), SOX2, NANOG bind SALL1 promoter	yes	reactome/R-HSA-2972975.md	POU5F1 (OCT4), SOX2, NANOG Bind the SALL1 Promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (SALL1 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	82	R-HSA-2972977	POU5F1 (OCT4), SOX2, NANOG bind DKK1 promoter	yes	reactome/R-HSA-2972977.md	POU5F1 (OCT4), SOX2, NANOG bind the DKK1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (DKK1 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	83	R-HSA-2972978	POU5F1 (OCT4), SOX2, NANOG bind ZIC3 promoter	yes	reactome/R-HSA-2972978.md	POU5F1 (OCT4), SOX2, NANOG bind the ZIC3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (ZIC3 promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	84	R-HSA-2972979	POU5F1 (OCT4), NANOG bind CDX2 promoter	yes	reactome/R-HSA-2972979.md	POU5F1 (OCT4), NANOG bind the CDX2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (CDX2 promoter).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	85	R-HSA-452894	Expression of SOX2	yes	reactome/R-HSA-452894.md	Expression of SOX2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (Expression of SOX2).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	86	R-HSA-480204	POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind NANOG promoter	yes	reactome/R-HSA-480204.md	POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind the NANOG promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (NANOG promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	87	R-HSA-480685	POU5F1 (OCT4), SOX2, NANOG bind SOX2 promoter	yes	reactome/R-HSA-480685.md	POU5F1 (OCT4), SOX2, NANOG bind the SOX2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (SOX2 promoter autoregulation).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	88	R-HSA-5626938	Beta-catenin binds SOX proteins	yes	reactome/R-HSA-5626938.md	Beta-catenin binds SOX proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (Beta-catenin binds SOX proteins).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	89	R-HSA-6790036	Expression of STAT3-upregulated nuclear proteins	yes	reactome/R-HSA-6790036.md	Expression of STAT3-upregulated nuclear proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (STAT3-upregulated nuclear proteins).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	90	R-HSA-6800120	POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene	yes	reactome/R-HSA-6800120.md	POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (DPPA4 gene binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	91	R-HSA-9732125	SOX2 binds MITF promoter	yes	reactome/R-HSA-9732125.md	SOX2 binds the MITF promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (MITF promoter binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	92	R-HSA-9833066	SOX2 binds ZEB2 gene	yes	reactome/R-HSA-9833066.md	SOX2 binds the ZEB2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (ZEB2 gene binding).
human	SOX2	genes/human/SOX2/SOX2-ai-review.yaml	SOX2	P48431	NCBITaxon:9606	Homo sapiens	93	R-HSA-9926523	MITF-M-dependent SOX2 gene expression	yes	reactome/R-HSA-9926523.md	MITF-M-dependent SOX2 gene expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS from Reactome (MITF-dependent SOX2 expression).
human	SOX9	genes/human/SOX9/SOX9-ai-review.yaml	SOX9	P48436	NCBITaxon:9606	Homo sapiens	102	R-HSA-5626938	Reactome pathway reference	yes	reactome/R-HSA-5626938.md	Beta-catenin binds SOX proteins	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Duplicate nucleoplasm annotation from Reactome.
human	SOX9	genes/human/SOX9/SOX9-ai-review.yaml	SOX9	P48436	NCBITaxon:9606	Homo sapiens	103	R-HSA-8985343	Reactome pathway reference	yes	reactome/R-HSA-8985343.md	RUNX2 binds SOX9	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Another Reactome TAS annotation for nucleoplasm.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	15	R-HSA-9612277	SPARC gene transcription is stimulated by ERBB4s80	yes	reactome/R-HSA-9612277.md	SPARC gene transcription is stimulated by ERBB4s80	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization is supported by experimental evidence, though this specific citation may be from a pathway context.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	35	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SPARC in platelet degranulation.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	36	R-HSA-2247513	STAB1:ligand is endocytosed	yes	reactome/R-HSA-2247513.md	STAB1:ligand is endocytosed	Homo sapiens	GO:0071682	endocytic vesicle lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for SPARC uptake via STAB1-mediated endocytosis.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	37	R-HSA-2197770	STAB1 (FEEL-1) binds ligands	yes	reactome/R-HSA-2197770.md	STAB1 (FEEL-1) binds ligands	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SPARC as STAB1 ligand.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	38	R-HSA-2247513	STAB1:ligand is endocytosed	yes	reactome/R-HSA-2247513.md	STAB1:ligand is endocytosed	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for STAB1-mediated endocytosis of extracellular SPARC.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	39	R-HSA-2424243	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+	yes	reactome/R-HSA-2424243.md	SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SPARC binding to collagen, hydroxylapatite, and Ca2+.
human	SPARC	genes/human/SPARC/SPARC-ai-review.yaml	SPARC	P09486	NCBITaxon:9606	Homo sapiens	40	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome annotation for SPARC release during platelet degranulation.
human	SPCS1	genes/human/SPCS1/SPCS1-ai-review.yaml	SPCS1	Q9Y6A9	NCBITaxon:9606	Homo sapiens	16	R-HSA-422051	Cleavage of the signal peptide of Preproghrelin	yes	reactome/R-HSA-422051.md	Cleavage of the signal peptide of Preproghrelin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS1 ER membrane localization (preproghrelin signal peptide cleavage context).
human	SPCS1	genes/human/SPCS1/SPCS1-ai-review.yaml	SPCS1	Q9Y6A9	NCBITaxon:9606	Homo sapiens	17	R-HSA-9918795	Signalase cleaves prM-E-NS1-NS2A	yes	reactome/R-HSA-9918795.md	Signalase cleaves prM-E-NS1-NS2A	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS1 ER membrane localization (flavivirus signalase cleavage context).
human	SPCS1	genes/human/SPCS1/SPCS1-ai-review.yaml	SPCS1	Q9Y6A9	NCBITaxon:9606	Homo sapiens	18	R-HSA-9918871	Signalase cleaves prepro-NS4B	yes	reactome/R-HSA-9918871.md	Signalase cleaves prepro-NS4B	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS1 ER membrane localization (signalase cleavage context).
human	SPCS2	genes/human/SPCS2/SPCS2-ai-review.yaml	SPCS2	Q15005	NCBITaxon:9606	Homo sapiens	12	R-HSA-422051	Cleavage of the signal peptide of Preproghrelin	yes	reactome/R-HSA-422051.md	Cleavage of the signal peptide of Preproghrelin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS2 ER membrane localization (preproghrelin signal peptide cleavage context).
human	SPCS2	genes/human/SPCS2/SPCS2-ai-review.yaml	SPCS2	Q15005	NCBITaxon:9606	Homo sapiens	13	R-HSA-9918795	Signalase cleaves prM-E-NS1-NS2A	yes	reactome/R-HSA-9918795.md	Signalase cleaves prM-E-NS1-NS2A	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS2 ER membrane localization (flavivirus signalase cleavage context).
human	SPCS2	genes/human/SPCS2/SPCS2-ai-review.yaml	SPCS2	Q15005	NCBITaxon:9606	Homo sapiens	14	R-HSA-9918871	Signalase cleaves prepro-NS4B	yes	reactome/R-HSA-9918871.md	Signalase cleaves prepro-NS4B	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS2 ER membrane localization (signalase cleavage context).
human	SPCS3	genes/human/SPCS3/SPCS3-ai-review.yaml	SPCS3	P61009	NCBITaxon:9606	Homo sapiens	19	R-HSA-422051	Cleavage of the signal peptide of Preproghrelin	yes	reactome/R-HSA-422051.md	Cleavage of the signal peptide of Preproghrelin	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS3 ER membrane localization (preproghrelin signal peptide cleavage context).
human	SPCS3	genes/human/SPCS3/SPCS3-ai-review.yaml	SPCS3	P61009	NCBITaxon:9606	Homo sapiens	20	R-HSA-9918795	Signalase cleaves prM-E-NS1-NS2A	yes	reactome/R-HSA-9918795.md	Signalase cleaves prM-E-NS1-NS2A	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS3 ER membrane localization (flavivirus signalase cleavage context).
human	SPCS3	genes/human/SPCS3/SPCS3-ai-review.yaml	SPCS3	P61009	NCBITaxon:9606	Homo sapiens	21	R-HSA-9918871	Signalase cleaves prepro-NS4B	yes	reactome/R-HSA-9918871.md	Signalase cleaves prepro-NS4B	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of SPCS3 ER membrane localization (signalase cleavage context).
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	22	R-HSA-141409	Mad1 binds kinetochore	yes	reactome/R-HSA-141409.md	Mad1 binds kinetochore	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Cytosol annotation from Reactome pathway ""Mad1 binds kinetochore."" Spindly is included as a participant in SAC-related Reactome reactions. Multiple redundant TAS annotations for the same GO term from different Reactome reactions. The cytosol localization is correct as the interphase/soluble pool of Spindly, but this is non-core. Consolidating all Reactome cytosol entries into a single review."
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	23	R-HSA-141422	MAD2 converted to an inhibitory state via interaction with Mad1	yes	reactome/R-HSA-141422.md	MAD2 converted to an inhibitory state via interaction with Mad1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	24	R-HSA-141431	MAD2 associates with the Mad1 kinetochore complex	yes	reactome/R-HSA-141431.md	MAD2 associates with the Mad1 kinetochore complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	25	R-HSA-141439	Release of activated MAD2 from kinetochores	yes	reactome/R-HSA-141439.md	Release of activated MAD2 from kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	26	R-HSA-1638803	Phosphorylation of cohesin by PLK1 at centromeres	yes	reactome/R-HSA-1638803.md	Phosphorylation of cohesin by PLK1 at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	27	R-HSA-1638821	PP2A-B56 dephosphorylates centromeric cohesin	yes	reactome/R-HSA-1638821.md	PP2A-B56 dephosphorylates centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	28	R-HSA-2467809	ESPL1 (Separase) cleaves centromeric cohesin	yes	reactome/R-HSA-2467809.md	ESPL1 (Separase) cleaves centromeric cohesin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	29	R-HSA-2467811	Separation of sister chromatids	yes	reactome/R-HSA-2467811.md	Separation of sister chromatids	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	30	R-HSA-2468287	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	yes	reactome/R-HSA-2468287.md	CDK1 phosphorylates CDCA5 (Sororin) at centromeres	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	31	R-HSA-2484822	Kinetochore assembly	yes	reactome/R-HSA-2484822.md	Kinetochore assembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	32	R-HSA-375302	Kinetochore capture of astral microtubules	yes	reactome/R-HSA-375302.md	Kinetochore capture of astral microtubules	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	33	R-HSA-5666129	CDC42:GTP recruits DIAPH2-2 to kinetochores	yes	reactome/R-HSA-5666129.md	CDC42:GTP recruits DIAPH2-2 to kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	34	R-HSA-5666160	AURKB phosphorylates DIAPH2-2 at kinetochores	yes	reactome/R-HSA-5666160.md	AURKB phosphorylates DIAPH2-2 at kinetochores	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	35	R-HSA-5666169	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	yes	reactome/R-HSA-5666169.md	Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPDL1	genes/human/SPDL1/SPDL1-ai-review.yaml	SPDL1	Q96EA4	NCBITaxon:9606	Homo sapiens	36	R-HSA-9648114	EML4 recruits NUDC to mitotic spindle	yes	reactome/R-HSA-9648114.md	EML4 recruits NUDC to mitotic spindle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Redundant cytosol TAS annotation from Reactome. Same assessment as above.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	38	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome pathway annotation placing SPHK1 in sphingolipid biosynthesis (production of S1P). Correct and relevant to the core metabolic function.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	39	R-HSA-5218845	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0008481	sphingosine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS of the core sphingosine kinase activity.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	40	R-HSA-9625814	SPHK1 phosphorylates sphingosine in response to E2 stimulation	yes	reactome/R-HSA-9625814.md	SPHK1 phosphorylates sphingosine in response to E2 stimulation	Homo sapiens	GO:0008481	sphingosine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS of the core sphingosine kinase activity (estrogen-stimulated context).
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	54	R-HSA-428273	SPHK1 phosphorylates sphingoid	yes	reactome/R-HSA-428273.md	SPHK1 phosphorylates sphingoid	Homo sapiens	GO:0001727	lipid kinase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome generic lipid kinase activity. Correct but subsumed by the specific sphingosine kinase activity term.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	55	R-HSA-9836617	p-PKR dimer phosphorylates SPHK1	yes	reactome/R-HSA-9836617.md	p-PKR dimer phosphorylates SPHK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasm localization (PKR-mediated signaling module). Consistent with nuclear shuttling; non-core.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	56	R-HSA-9836621	p-S225-SPHK1 localizes to cytosol	yes	reactome/R-HSA-9836621.md	p-S225-SPHK1 localizes to cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasm localization. Non-core.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	87	R-HSA-5218823	PKC phosphorylates sphingosine kinase 1	yes	reactome/R-HSA-5218823.md	PKC phosphorylates sphingosine kinase 1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization (PKC-phosphorylation module). Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	88	R-HSA-5218845	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	yes	reactome/R-HSA-5218845.md	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	89	R-HSA-9836606	SPHK1 binds PKR	yes	reactome/R-HSA-9836606.md	SPHK1 binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	90	R-HSA-9836621	p-S225-SPHK1 localizes to cytosol	yes	reactome/R-HSA-9836621.md	p-S225-SPHK1 localizes to cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	91	R-HSA-391266	Association of CCT/TriC with sphingosine kinase 1	yes	reactome/R-HSA-391266.md	Association of CCT/TriC with sphingosine kinase 1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	92	R-HSA-428273	SPHK1 phosphorylates sphingoid	yes	reactome/R-HSA-428273.md	SPHK1 phosphorylates sphingoid	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization (the SPHK1 phosphorylates sphingoid reaction). Core resting compartment.
human	SPHK1	genes/human/SPHK1/SPHK1-ai-review.yaml	SPHK1	Q9NYA1	NCBITaxon:9606	Homo sapiens	93	R-HSA-9625814	SPHK1 phosphorylates sphingosine in response to E2 stimulation	yes	reactome/R-HSA-9625814.md	SPHK1 phosphorylates sphingosine in response to E2 stimulation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol localization. Core resting compartment.
human	SPHK2	genes/human/SPHK2/SPHK2-ai-review.yaml	SPHK2	Q9NRA0	NCBITaxon:9606	Homo sapiens	38	R-HSA-1660661	Sphingolipid de novo biosynthesis	yes	reactome/R-HSA-1660661.md	Sphingolipid de novo biosynthesis	Homo sapiens	GO:0030148	sphingolipid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway assignment (sphingolipid de novo biosynthesis). Correct pathway context; broader than the specific S1P-biosynthesis role but a reasonable non-core process annotation.
human	SPHK2	genes/human/SPHK2/SPHK2-ai-review.yaml	SPHK2	Q9NRA0	NCBITaxon:9606	Homo sapiens	51	R-HSA-9695949	SPHK2 phosphorylates sphingoid	yes	reactome/R-HSA-9695949.md	SPHK2 phosphorylates sphingoid	Homo sapiens	GO:0001727	lipid kinase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome TAS to the parent 'lipid kinase activity'. Correct but less informative than the specific sphingosine kinase activity term.
human	SPHK2	genes/human/SPHK2/SPHK2-ai-review.yaml	SPHK2	Q9NRA0	NCBITaxon:9606	Homo sapiens	87	R-HSA-9695917	SPHK2 binds SPHK2 inhibitors	yes	reactome/R-HSA-9695917.md	SPHK2 binds SPHK2 inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (SPHK2-inhibitor-binding reaction context). Consistent with cytosolic localization; non-core.
human	SPHK2	genes/human/SPHK2/SPHK2-ai-review.yaml	SPHK2	Q9NRA0	NCBITaxon:9606	Homo sapiens	88	R-HSA-9695949	SPHK2 phosphorylates sphingoid	yes	reactome/R-HSA-9695949.md	SPHK2 phosphorylates sphingoid	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome cytosolic localization (SPHK2 phosphorylates sphingoid reaction context). Consistent with cytosolic localization; non-core.
human	SPI1	genes/human/SPI1/SPI1-ai-review.yaml	SPI1	P17947	NCBITaxon:9606	Homo sapiens	126	R-HSA-9617064	SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene	yes	reactome/R-HSA-9617064.md	SPI1 (PU.1), PML isoform 4, and EP300 bind the promoter of the CEBPE gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	PU.1 is a nuclear/chromatin transcription factor.
human	SPI1	genes/human/SPI1/SPI1-ai-review.yaml	SPI1	P17947	NCBITaxon:9606	Homo sapiens	127	R-HSA-9617207	SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene	yes	reactome/R-HSA-9617207.md	SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	PU.1 is a nuclear/chromatin transcription factor.
human	SPR	genes/human/SPR/SPR-ai-review.yaml	SPR	P35270	NCBITaxon:9606	Homo sapiens	11	R-HSA-1497853	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II	yes	reactome/R-HSA-1497853.md	Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway annotation for SPR phosphorylation by CaMK2. The reaction occurs in the cytosol. However, note that UniProt indicates the Ser-213 phosphorylation by CaMK2 does not change kinetic parameters.
human	SPR	genes/human/SPR/SPR-ai-review.yaml	SPR	P35270	NCBITaxon:9606	Homo sapiens	12	R-HSA-1475414	PTHP is reduced to BH4 by sepiapterin reductase (SPR)	yes	reactome/R-HSA-1475414.md	PTHP is reduced to BH4 by sepiapterin reductase (SPR)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for the de novo BH4 synthesis reaction where SPR reduces DHNTP (6-pyruvoyltetrahydropterin precursor) to BH4.
human	SPR	genes/human/SPR/SPR-ai-review.yaml	SPR	P35270	NCBITaxon:9606	Homo sapiens	13	R-HSA-1497869	Salvage - Sepiapterin is reduced to q-BH2	yes	reactome/R-HSA-1497869.md	Salvage - Sepiapterin is reduced to q-BH2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome for the BH4 salvage pathway where SPR reduces sepiapterin to BH2.
human	SPTLC1	genes/human/SPTLC1/SPTLC1-ai-review.yaml	SPTLC1	O15269	NCBITaxon:9606	Homo sapiens	28	R-HSA-428127	SPTLC complexes transfer acyl-CoA onto serine	yes	reactome/R-HSA-428127.md	SPTLC complexes transfer acyl-CoA onto serine	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the SPTLC complexes at the ER membrane where they transfer acyl-CoA onto serine.
human	SPTLC2	genes/human/SPTLC2/SPTLC2-ai-review.yaml	SPTLC2	O15270	NCBITaxon:9606	Homo sapiens	30	R-HSA-428127	SPTLC complexes transfer acyl-CoA onto serine	yes	reactome/R-HSA-428127.md	SPTLC complexes transfer acyl-CoA onto serine	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the SPTLC complexes / acyl-CoA transfer onto serine at the ER membrane.
human	SPTSSA	genes/human/SPTSSA/SPTSSA-ai-review.yaml	SPTSSA	Q969W0	NCBITaxon:9606	Homo sapiens	25	R-HSA-428127	SPTLC complexes transfer acyl-CoA onto serine	yes	reactome/R-HSA-428127.md	SPTLC complexes transfer acyl-CoA onto serine	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Traceable-author-statement (Reactome) localization to the ER membrane, consistent with all other localization evidence.
human	SQLE	genes/human/SQLE/SQLE-ai-review.yaml	SQLE	Q14534	NCBITaxon:9606	Homo sapiens	24	R-HSA-1655844	Expression of Squalene Monooxygenase (SQLE)	yes	reactome/R-HSA-1655844.md	Expression of Squalene Monooxygenase (SQLE)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing SQLE at the ER membrane (Expression of Squalene Monooxygenase module). Consistent with all other evidence.
human	SQLE	genes/human/SQLE/SQLE-ai-review.yaml	SQLE	Q14534	NCBITaxon:9606	Homo sapiens	25	R-HSA-191299	Squalene is oxidized to its epoxide	yes	reactome/R-HSA-191299.md	Squalene is oxidized to its epoxide	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS for the reaction ""Squalene is oxidized to its epoxide"", placing squalene monooxygenase at the ER membrane."
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	110	R-HSA-205043	NRIF signals cell death from the nucleus	yes	reactome/R-HSA-205043.md	NRIF signals cell death from the nucleus	Homo sapiens	GO:0043065	positive regulation of apoptotic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome curation linking p62 to positive regulation of apoptosis in the NRIF death-signaling pathway.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	186	R-HSA-9759169	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	yes	reactome/R-HSA-9759169.md	p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	187	R-HSA-9759172	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	yes	reactome/R-HSA-9759172.md	KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	188	R-HSA-9766532	SQSTM1 oligomer is phosphorylated	yes	reactome/R-HSA-9766532.md	SQSTM1 oligomer is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	189	R-HSA-9766645	CUL3:RBX1 ubiquitinates KEAP1	yes	reactome/R-HSA-9766645.md	CUL3:RBX1 ubiquitinates KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	190	R-HSA-9766656	RBX1:CUL3 dissociates from forming autophagosome	yes	reactome/R-HSA-9766656.md	RBX1:CUL3 dissociates from forming autophagosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	191	R-HSA-9766677	MAP1LC3B binds KEAP1 and SQSTM1	yes	reactome/R-HSA-9766677.md	MAP1LC3B binds KEAP1 and SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	192	R-HSA-9766687	SESN1,SESN1 bind SQSTM1 and KEAP1	yes	reactome/R-HSA-9766687.md	SESN1,SESN1 bind SQSTM1 and KEAP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	193	R-HSA-9759154	TRIM21 ubiquitinates SQSTM1	yes	reactome/R-HSA-9759154.md	TRIM21 ubiquitinates SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	195	R-HSA-205008	Polyubiquitinated NRIF binds to p62 (Sequestosome)	yes	reactome/R-HSA-205008.md	Polyubiquitinated NRIF binds to p62 (Sequestosome)	Homo sapiens	GO:0043130	ubiquitin binding	TAS	enables	MF	false		ACCEPT	Direct evidence that p62 binds ubiquitin via its UBA domain.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	230	R-HSA-193641	IKK-beta is recruited	yes	reactome/R-HSA-193641.md	IKK-beta is recruited	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	231	R-HSA-193684	p62 recruits an atypical PKC	yes	reactome/R-HSA-193684.md	p62 recruits an atypical PKC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	232	R-HSA-193694	p62 is recruited and forms a complex with TRAF6	yes	reactome/R-HSA-193694.md	p62 is recruited and forms a complex with TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	233	R-HSA-193703	IKKbeta is activated	yes	reactome/R-HSA-193703.md	IKKbeta is activated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	234	R-HSA-193705	IKKbeta phosphorylates IkB causing NF-kB to dissociate	yes	reactome/R-HSA-193705.md	IKKbeta phosphorylates IkB causing NF-kB to dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	235	R-HSA-204947	Polyubiquitinated NRIF migrates to the nucleus	yes	reactome/R-HSA-204947.md	Polyubiquitinated NRIF migrates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	236	R-HSA-205008	Polyubiquitinated NRIF binds to p62 (Sequestosome)	yes	reactome/R-HSA-205008.md	Polyubiquitinated NRIF binds to p62 (Sequestosome)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	237	R-HSA-209566	TRAF6 is auto-ubiquitinated	yes	reactome/R-HSA-209566.md	TRAF6 is auto-ubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	238	R-HSA-507719	p62:MEKK3 binds to TRAF6	yes	reactome/R-HSA-507719.md	p62:MEKK3 binds to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	239	R-HSA-5205649	p62 links damaged mitochondria to LC3	yes	reactome/R-HSA-5205649.md	p62 links damaged mitochondria to LC3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	240	R-HSA-5205663	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-5205663.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	241	R-HSA-5205673	p62 binds ubiquitinated mitochondrial substrates	yes	reactome/R-HSA-5205673.md	p62 binds ubiquitinated mitochondrial substrates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	242	R-HSA-9664855	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664855.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	243	R-HSA-9664880	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	yes	reactome/R-HSA-9664880.md	MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	244	R-HSA-9664881	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	yes	reactome/R-HSA-9664881.md	NBR1 binds ATM:Ub-p-PEX5:SQSTM1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	245	R-HSA-9664892	SQSTM1 binds ATM dimer:Ub-p-PEX5	yes	reactome/R-HSA-9664892.md	SQSTM1 binds ATM dimer:Ub-p-PEX5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	246	R-HSA-9759157	NFE2L2-dependent SQSTM1 gene expression	yes	reactome/R-HSA-9759157.md	NFE2L2-dependent SQSTM1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	247	R-HSA-9759158	SQSTM1 oligomerizes	yes	reactome/R-HSA-9759158.md	SQSTM1 oligomerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	248	R-HSA-9761900	HBV X protein binds SQSTM1 oligomer	yes	reactome/R-HSA-9761900.md	HBV X protein binds SQSTM1 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is the core compartment of p62 oligomerization, cargo binding and condensate formation.
human	SQSTM1	genes/human/SQSTM1/SQSTM1-ai-review.yaml	SQSTM1	Q13501	NCBITaxon:9606	Homo sapiens	250	R-HSA-204947	Polyubiquitinated NRIF migrates to the nucleus	yes	reactome/R-HSA-204947.md	Polyubiquitinated NRIF migrates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome curation placing p62 in the nucleoplasm in the NRIF death-signaling context.
human	SRD5A2	genes/human/SRD5A2/SRD5A2-ai-review.yaml	SRD5A2	P31213	NCBITaxon:9606	Homo sapiens	35	R-HSA-193048	Androgen biosynthesis	yes	reactome/R-HSA-193048.md	Androgen biosynthesis	Homo sapiens	GO:0006702	androgen biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable-author-statement placing SRD5A2 in androgen biosynthesis. Consistent with its role in producing DHT.
human	SRD5A2	genes/human/SRD5A2/SRD5A2-ai-review.yaml	SRD5A2	P31213	NCBITaxon:9606	Homo sapiens	36	R-HSA-9705713	SRD5A2 dehydrogenates TEST to DHTEST	yes	reactome/R-HSA-9705713.md	SRD5A2 dehydrogenates TEST to DHTEST	Homo sapiens	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS	enables	MF	false		ACCEPT	Reactome TAS for the core enzymatic activity, based on the SRD5A2-catalyzed testosterone-to-DHT reaction. Matches the experimental and IBA molecular function.
human	SRD5A2	genes/human/SRD5A2/SRD5A2-ai-review.yaml	SRD5A2	P31213	NCBITaxon:9606	Homo sapiens	40	R-HSA-9705713	SRD5A2 dehydrogenates TEST to DHTEST	yes	reactome/R-HSA-9705713.md	SRD5A2 dehydrogenates TEST to DHTEST	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing SRD5A2 to the ER membrane, matching the curated microsomal (ER) membrane localization.
human	SRD5A2	genes/human/SRD5A2/SRD5A2-ai-review.yaml	SRD5A2	P31213	NCBITaxon:9606	Homo sapiens	41	R-HSA-9705794	SRD5A2 binds SRD5A2 inhibitors	yes	reactome/R-HSA-9705794.md	SRD5A2 binds SRD5A2 inhibitors	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (inhibitor-binding reaction) localizing SRD5A2 to the ER membrane. Duplicates the ER-membrane localization.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	12	R-HSA-193048	Androgen biosynthesis	yes	reactome/R-HSA-193048.md	Androgen biosynthesis	Homo sapiens	GO:0006702	androgen biosynthetic process	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome-derived annotation placing SRD5A3 in androgen biosynthesis, based on the prostate-cancer report that SRD5A3 can convert testosterone to dihydrotestosterone in vitro (Uemura et al. 2008). SRD5A3 is named a steroid 5-alpha-reductase and shows weak in-vitro DHT-forming activity, but its physiological function is dolichol synthesis, not androgen metabolism; this is an over-annotation of a marginal side activity.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	13	R-HSA-446199	Synthesis of dolichyl-phosphate	yes	reactome/R-HSA-446199.md	Synthesis of dolichyl-phosphate	Homo sapiens	GO:0043048	dolichyl monophosphate biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome-authored annotation (Synthesis of dolichyl-phosphate) to the core dolichyl monophosphate biosynthetic process. Consistent with the experimental and IBA annotations.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	14	R-HSA-9705714	SRD5A3 dehydrogenates TEST to DHTEST	yes	reactome/R-HSA-9705714.md	SRD5A3 dehydrogenates TEST to DHTEST	Homo sapiens	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome-derived steroid 5-alpha-reductase MF annotation (SRD5A3 dehydrogenates TEST to DHTEST), tracing to the in-vitro testosterone-to-DHT activity of Uemura et al. 2008. This is a weak, non-physiological side activity and an over-annotation relative to the enzyme's dolichol-pathway function.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	21	R-HSA-4755572	Defective SRD5A3 does not reduce pPNOL to DCHOL	yes	reactome/R-HSA-4755572.md	Defective SRD5A3 does not reduce pPNOL to DCHOL	Homo sapiens	GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	TAS	enables	MF	false		KEEP_AS_NON_CORE	Reactome-derived high-level oxidoreductase MF annotation. Correct as a parent class of the polyprenal reductase reaction (NADPH-dependent reduction of a C=C bond) but general.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	22	R-HSA-4755572	Defective SRD5A3 does not reduce pPNOL to DCHOL	yes	reactome/R-HSA-4755572.md	Defective SRD5A3 does not reduce pPNOL to DCHOL	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-authored ER membrane localization, consistent with the experimental IDA localization. Core localization.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	23	R-HSA-9705714	SRD5A3 dehydrogenates TEST to DHTEST	yes	reactome/R-HSA-9705714.md	SRD5A3 dehydrogenates TEST to DHTEST	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-authored ER membrane localization (from the steroid-reaction module), consistent with experimental data. Core localization.
human	SRD5A3	genes/human/SRD5A3/SRD5A3-ai-review.yaml	SRD5A3	Q9H8P0	NCBITaxon:9606	Homo sapiens	24	R-HSA-9937295	SRD5A3 reduces polyprenal to dolichal	yes	reactome/R-HSA-9937295.md	SRD5A3 reduces polyprenal to dolichal	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-authored ER membrane localization (from the revised polyprenal-to-dolichal reaction module), consistent with experimental data. Core localization.
human	SRM	genes/human/SRM/SRM-ai-review.yaml	SRM	P19623	NCBITaxon:9606	Homo sapiens	13	R-HSA-351202	Metabolism of polyamines	yes	reactome/R-HSA-351202.md	Metabolism of polyamines	Homo sapiens	GO:0006595	polyamine metabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome traceable annotation placing SRM in Metabolism of polyamines. Correct but a broad process term; the specific spermidine biosynthetic process (GO:0008295) is the precise core process. Keep as non-core contextual annotation.
human	SRM	genes/human/SRM/SRM-ai-review.yaml	SRM	P19623	NCBITaxon:9606	Homo sapiens	16	R-HSA-351215	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine	yes	reactome/R-HSA-351215.md	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable annotation placing the spermidine-synthesis reaction in the cytosol. Consistent with the IBA cytosol call and the cytosolic nature of polyamine biosynthesis. Accept as core localization.
human	SRP19	genes/human/SRP19/SRP19-ai-review.yaml	SRP19	P09132	NCBITaxon:9606	Homo sapiens	15	R-HSA-1799332	Reactome: Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization, consistent with SRP's cytoplasmic site of action.
human	SRP68	genes/human/SRP68/SRP68-ai-review.yaml	SRP68	Q9UHB9	NCBITaxon:9606	Homo sapiens	31	R-HSA-1799332	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of SRP68 cytosolic localization within the SRP targeting reaction.
human	SRP72	genes/human/SRP72/SRP72-ai-review.yaml	SRP72	O76094	NCBITaxon:9606	Homo sapiens	26	R-HSA-1799332	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of SRP72 cytosolic localization within the SRP-targeting reaction. Core compartment.
human	SRP9	genes/human/SRP9/SRP9-ai-review.yaml	SRP9	P49458	NCBITaxon:9606	Homo sapiens	20	R-HSA-1799332	Reactome: Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	yes	reactome/R-HSA-1799332.md	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization, consistent with SRP's cytoplasmic site of action.
human	SRPRB	genes/human/SRPRB/SRPRB-ai-review.yaml	SRPRB	Q9Y5M8	NCBITaxon:9606	Homo sapiens	13	R-HSA-1791060	Expression of SRPRB (SRP Receptor subunit beta)	yes	reactome/R-HSA-1791060.md	Expression of SRPRB (SRP Receptor subunit beta)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation of ER membrane localization for SRPRB, consistent with the core compartment.
human	SSR1	genes/human/SSR1/SSR1-ai-review.yaml	SSR1	P43307	NCBITaxon:9606	Homo sapiens	11	R-HSA-1791164	Expression of SSR1 (Trap alpha)	yes	reactome/R-HSA-1791164.md	Expression of SSR1 (Trap alpha)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""Expression of SSR1 (Trap alpha)"" indicating ER membrane localization."
human	ST3GAL5	genes/human/ST3GAL5/ST3GAL5-ai-review.yaml	ST3GAL5	Q9UNP4	NCBITaxon:9606	Homo sapiens	7	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome (TAS) annotation to glycosphingolipid biosynthesis. This is correct - GM3 is a glycosphingolipid and ganglioside biosynthesis is a subprocess of glycosphingolipid biosynthesis. It is a valid but broader parent of the more specific ganglioside biosynthetic process, so retained as non-core.
human	ST3GAL5	genes/human/ST3GAL5/ST3GAL5-ai-review.yaml	ST3GAL5	Q9UNP4	NCBITaxon:9606	Homo sapiens	8	R-HSA-4084984	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)	yes	reactome/R-HSA-4084984.md	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)	Homo sapiens	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	TAS	enables	MF	false		MODIFY	"Reactome (TAS) family-level annotation from the reaction ""ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)"". GO:0003836 is defined for the beta-D-galactosyl-(1->3)-GalNAc-R (O-glycan) acceptor reaction shared by the ST3GAL family, not for the LacCer -> GM3 reaction that defines ST3GAL5. The gene-specific term GO:0047291 better represents this enzyme's characterized activity."
human	ST3GAL5	genes/human/ST3GAL5/ST3GAL5-ai-review.yaml	ST3GAL5	Q9UNP4	NCBITaxon:9606	Homo sapiens	9	R-HSA-9844860	ST3GAL5 transfers NeuNAc to ceramides	yes	reactome/R-HSA-9844860.md	ST3GAL5 transfers NeuNAc to ceramides	Homo sapiens	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	TAS	enables	MF	false		MODIFY	"Reactome (TAS) annotation from ""ST3GAL5 transfers NeuNAc to ceramides"". Although the Reactome reaction is ST3GAL5-specific, the mapped GO term GO:0003836 is the generic beta-galactoside (O-glycan Gal-1,3-GalNAc-R) sialyltransferase term rather than the glycosphingolipid GM3 synthase term. The gene-specific GO:0047291 more precisely captures the LacCer -> GM3 activity described by this Reactome event."
human	ST3GAL5	genes/human/ST3GAL5/ST3GAL5-ai-review.yaml	ST3GAL5	Q9UNP4	NCBITaxon:9606	Homo sapiens	11	R-HSA-4084984	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)	yes	reactome/R-HSA-4084984.md	ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation placing the ST3GAL1-6 alpha-2,3- sialyltransferase reaction in the Golgi membrane, consistent with the UniProt subcellular location. Correct location.
human	ST3GAL5	genes/human/ST3GAL5/ST3GAL5-ai-review.yaml	ST3GAL5	Q9UNP4	NCBITaxon:9606	Homo sapiens	12	R-HSA-9844860	ST3GAL5 transfers NeuNAc to ceramides	yes	reactome/R-HSA-9844860.md	ST3GAL5 transfers NeuNAc to ceramides	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) annotation localizing the ST3GAL5 ceramide sialylation reaction to the Golgi membrane, consistent with UniProt. Correct location.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	11	R-HSA-977068	Termination of O-glycan biosynthesis	yes	reactome/R-HSA-977068.md	Termination of O-glycan biosynthesis	Homo sapiens	GO:0016266	protein O-linked glycosylation via N-acetylgalactosamine	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ST6GAL1 is predominantly an N-glycan alpha-2,6-sialyltransferase, but Reactome documents a minor activity terminating O-GalNAc (mucin-type) glycans, including conversion of Tn to sialyl-Tn antigen. This O-glycan role is real but minor and context-specific relative to the dominant N-glycan function; kept as non-core.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	12	R-HSA-4085033	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)	yes	reactome/R-HSA-4085033.md	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)	Homo sapiens	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	TAS	enables	MF	false		ACCEPT	"Core catalytic MF (Reactome reaction ""ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)""). Correct; redundant with the experimentally supported annotations to the same term."
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	13	R-HSA-975902	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans	yes	reactome/R-HSA-975902.md	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans	Homo sapiens	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	TAS	enables	MF	false		ACCEPT	"Core catalytic MF (Reactome ""ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans""). Correct; redundant duplicate."
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	14	R-HSA-977071	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	yes	reactome/R-HSA-977071.md	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	Homo sapiens	GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity	TAS	enables	MF	false		ACCEPT	Core catalytic MF; this Reactome reaction concerns transfer of sialic acid to Tn antigens to form sialyl-Tn. The activity is correct (same enzyme), though the O-GalNAc/sTn acceptor is a minor context relative to the N-glycan role.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	19	R-HSA-9683673	Maturation of protein 3a	yes	reactome/R-HSA-9683673.md	Maturation of protein 3a	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"This annotation comes from Reactome SARS-CoV-2 pathways in which cellular sialyltransferases glycosylate viral proteins (here ORF3a). The underlying molecular event is ST6GAL1's ordinary host-glycosylation activity; framing a housekeeping glycosylation step as a dedicated ""viral protein processing"" function over-extends the gene's role. The enzyme is not virus-specific."
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	20	R-HSA-9694548	Maturation of spike protein	yes	reactome/R-HSA-9694548.md	Maturation of spike protein	Homo sapiens	GO:0019082	viral protein processing	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Same as above (Reactome SARS-CoV-2 spike maturation). The molecular event is generic host sialylation of viral glycoproteins; ""viral protein processing"" over-extends ST6GAL1's role. The Reactome curation even states the spike sialic acids are added ""presumably by the cell's sialyltransferases""."
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	21	R-HSA-9683769	O-glycosylation of 3a is terminated	yes	reactome/R-HSA-9683769.md	O-glycosylation of 3a is terminated	Homo sapiens	GO:0008373	sialyltransferase activity	TAS	enables	MF	false		MODIFY	Over-general parent MF asserted within a SARS-CoV-2 O-glycosylation Reactome reaction. The specific activity GO:0003835 is established for ST6GAL1 and should be used instead of the parent sialyltransferase activity term.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	22	R-HSA-9697018	Addition of sialic acids on some Spike glycosyl sidechains	yes	reactome/R-HSA-9697018.md	Addition of sialic acids on some Spike glycosyl sidechains	Homo sapiens	GO:0008373	sialyltransferase activity	TAS	enables	MF	false		MODIFY	Over-general parent MF asserted within a SARS-CoV-2 spike sialylation Reactome reaction. Replace with the specific GO:0003835 established for ST6GAL1.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	30	R-HSA-4085033	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)	yes	reactome/R-HSA-4085033.md	ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Core Golgi-membrane localization (Reactome). Correct; redundant with the IDA Golgi membrane annotation.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	31	R-HSA-9683769	O-glycosylation of 3a is terminated	yes	reactome/R-HSA-9683769.md	O-glycosylation of 3a is terminated	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Core Golgi-membrane localization asserted in a SARS-CoV-2 O-glycosylation Reactome reaction. The localization itself is correct (redundant duplicate).
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	32	R-HSA-9697018	Addition of sialic acids on some Spike glycosyl sidechains	yes	reactome/R-HSA-9697018.md	Addition of sialic acids on some Spike glycosyl sidechains	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Core Golgi-membrane localization asserted in a SARS-CoV-2 spike sialylation Reactome reaction. Correct; redundant duplicate.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	33	R-HSA-975902	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans	yes	reactome/R-HSA-975902.md	ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Core Golgi-membrane localization (Reactome N-glycan sialylation reaction). Correct; redundant duplicate.
human	ST6GAL1	genes/human/ST6GAL1/ST6GAL1-ai-review.yaml	ST6GAL1	P15907	NCBITaxon:9606	Homo sapiens	34	R-HSA-977071	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	yes	reactome/R-HSA-977071.md	ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Core Golgi-membrane localization (Reactome sialyl-Tn reaction). Correct; redundant duplicate.
human	ST8SIA1	genes/human/ST8SIA1/ST8SIA1-ai-review.yaml	ST8SIA1	Q92185	NCBITaxon:9606	Homo sapiens	10	R-HSA-4084978	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues	yes	reactome/R-HSA-4084978.md	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues	Homo sapiens	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) assertion of the core alpha-2,8-sialyltransferase activity, matching the experimental evidence. Core function.
human	ST8SIA1	genes/human/ST8SIA1/ST8SIA1-ai-review.yaml	ST8SIA1	Q92185	NCBITaxon:9606	Homo sapiens	18	R-HSA-4084978	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues	yes	reactome/R-HSA-4084978.md	ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) placement in the Golgi membrane, consistent with the UniProt subcellular location and its function as a Golgi ganglioside sialyltransferase. Core location.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	20	R-HSA-196108	Pregnenolone biosynthesis	yes	reactome/R-HSA-196108.md	Pregnenolone biosynthesis	Homo sapiens	GO:0006700	C21-steroid hormone biosynthetic process	TAS	involved_in	BP	false		ACCEPT	Reactome traceable annotation placing StAR in C21-steroid (pregnane) hormone biosynthesis, via the Pregnenolone biosynthesis pathway. Correct: StAR delivers cholesterol so CYP11A1 can generate pregnenolone (a C21-steroid), the precursor of glucocorticoids, mineralocorticoids and progestins.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	35	R-HSA-196126	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space	yes	reactome/R-HSA-196126.md	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space	Homo sapiens	GO:0140104	molecular carrier activity	TAS	enables	MF	false		MODIFY	Reactome traceable annotation to the broad molecular carrier activity term. StAR is indeed a cholesterol carrier, but the specific term cholesterol transfer activity (GO:0120020) is far more informative and is well supported experimentally.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	37	R-HSA-9838081	LONP1 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9838081.md	LONP1 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation placing StAR in the mitochondrial matrix, in the context of LONP1-mediated degradation of matrix proteins. This reflects that matrix-imported StAR is a substrate for matrix proteases, not that the matrix is its functional site.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	38	R-HSA-9838093	LONP1 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9838093.md	LONP1 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation to the mitochondrial matrix in the context of LONP1 binding matrix proteins. Same rationale: matrix-imported StAR is a protease substrate; the matrix is not its functional site.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	39	R-HSA-9839105	AFG3L2 degrades mitochondrial matrix proteins	yes	reactome/R-HSA-9839105.md	AFG3L2 degrades mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation to the mitochondrial matrix in the context of AFG3L2 degrading matrix proteins. Reflects matrix protein turnover, not the site of StAR activity.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	40	R-HSA-9839149	AFG3L2 binds mitochondrial matrix proteins	yes	reactome/R-HSA-9839149.md	AFG3L2 binds mitochondrial matrix proteins	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation to the mitochondrial matrix in the context of AFG3L2 binding matrix proteins. Same rationale as the other matrix degradation modules.
human	STAR	genes/human/STAR/STAR-ai-review.yaml	STAR	P49675	NCBITaxon:9606	Homo sapiens	43	R-HSA-196126	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space	yes	reactome/R-HSA-196126.md	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable annotation to the mitochondrial intermembrane space, in the model of StAR delivering cholesterol from the outer toward the inner membrane. StAR necessarily traverses/works across the intermembrane space during cholesterol delivery.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	185	R-HSA-9851142	TYK2-dependent STAT1 and STAT3 phosphorylation	yes	reactome/R-HSA-9851142.md	TYK2-dependent STAT1 and STAT3 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	186	R-HSA-8985981	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985981.md	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	187	R-HSA-8985983	p-Y701-STAT1 dimer translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985983.md	p-Y701-STAT1 dimer translocates from the cytosol to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	188	R-HSA-9865524	p-Y701-STAT1 binds the NLRP3 gene	yes	reactome/R-HSA-9865524.md	p-Y701-STAT1 binds the NLRP3 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	189	R-HSA-8985900	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	yes	reactome/R-HSA-8985900.md	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	190	R-HSA-8985943	p-Y701-STAT1 dimerizes	yes	reactome/R-HSA-8985943.md	p-Y701-STAT1 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	191	R-HSA-8985966	p-Y701-STAT1 binds p-Y705-STAT3	yes	reactome/R-HSA-8985966.md	p-Y701-STAT1 binds p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	192	R-HSA-8985981	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985981.md	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	193	R-HSA-8985983	p-Y701-STAT1 dimer translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985983.md	p-Y701-STAT1 dimer translocates from the cytosol to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	194	R-HSA-8985988	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	yes	reactome/R-HSA-8985988.md	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	195	R-HSA-9865511	Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE	yes	reactome/R-HSA-9865511.md	Phosphorylation of STAT1 on tyrosine-701 is enhanced by p-S172-IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	201	R-HSA-8987218	p-STAT1 dimer translocates from the cytosol to the nucleoplasm	yes	reactome/R-HSA-8987218.md	p-STAT1 dimer translocates from the cytosol to the nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	202	R-HSA-1112565	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	yes	reactome/R-HSA-1112565.md	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	203	R-HSA-1112602	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	yes	reactome/R-HSA-1112602.md	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	204	R-HSA-1169406	ISGylation of host proteins	yes	reactome/R-HSA-1169406.md	ISGylation of host proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	205	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	206	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	207	R-HSA-1678841	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18	yes	reactome/R-HSA-1678841.md	Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	208	R-HSA-1888198	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3	yes	reactome/R-HSA-1888198.md	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	209	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	210	R-HSA-6788571	STAT1,STAT3,STAT6 bind IL13:IL13R type II	yes	reactome/R-HSA-6788571.md	STAT1,STAT3,STAT6 bind IL13:IL13R type II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	211	R-HSA-6788582	STAT1,STAT3,STAT6 phosphorylation	yes	reactome/R-HSA-6788582.md	STAT1,STAT3,STAT6 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	212	R-HSA-6790041	Expression of STAT3-upregulated cytosolic proteins	yes	reactome/R-HSA-6790041.md	Expression of STAT3-upregulated cytosolic proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	213	R-HSA-8950441	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	yes	reactome/R-HSA-8950441.md	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	214	R-HSA-8950453	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	yes	reactome/R-HSA-8950453.md	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	215	R-HSA-8950485	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	yes	reactome/R-HSA-8950485.md	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	216	R-HSA-8950518	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	yes	reactome/R-HSA-8950518.md	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	217	R-HSA-8950522	p-STAT1:p-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950522.md	p-STAT1:p-STAT4 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	218	R-HSA-8983835	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1	yes	reactome/R-HSA-8983835.md	JAK1/JAK2/TYK2 bound to IL6ST:IL6ST phosphorylate STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	219	R-HSA-8983841	STAT1 associates with IL6ST:IL6ST	yes	reactome/R-HSA-8983841.md	STAT1 associates with IL6ST:IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	220	R-HSA-8983845	p-STAT1 dissociates from IL6ST:IL6ST	yes	reactome/R-HSA-8983845.md	p-STAT1 dissociates from IL6ST:IL6ST	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	221	R-HSA-8983983	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983983.md	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	222	R-HSA-8983996	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983996.md	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	223	R-HSA-8984014	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	yes	reactome/R-HSA-8984014.md	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	224	R-HSA-8984021	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984021.md	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	225	R-HSA-8984023	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984023.md	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	226	R-HSA-8985929	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	yes	reactome/R-HSA-8985929.md	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	227	R-HSA-8986985	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	yes	reactome/R-HSA-8986985.md	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	228	R-HSA-8987007	p-STAT1 dimerizes	yes	reactome/R-HSA-8987007.md	p-STAT1 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	229	R-HSA-8987033	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	yes	reactome/R-HSA-8987033.md	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	230	R-HSA-8987080	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	yes	reactome/R-HSA-8987080.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	231	R-HSA-8987097	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	yes	reactome/R-HSA-8987097.md	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	232	R-HSA-8987150	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	yes	reactome/R-HSA-8987150.md	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	233	R-HSA-8987218	p-STAT1 dimer translocates from the cytosol to the nucleoplasm	yes	reactome/R-HSA-8987218.md	p-STAT1 dimer translocates from the cytosol to the nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	234	R-HSA-8987230	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	yes	reactome/R-HSA-8987230.md	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	235	R-HSA-8987255	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	yes	reactome/R-HSA-8987255.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	236	R-HSA-8987266	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	yes	reactome/R-HSA-8987266.md	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	237	R-HSA-8987270	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	yes	reactome/R-HSA-8987270.md	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	238	R-HSA-9006870	IL21 receptor STAT phosphorylation	yes	reactome/R-HSA-9006870.md	IL21 receptor STAT phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	239	R-HSA-9006873	IL21 receptor STAT binding	yes	reactome/R-HSA-9006873.md	IL21 receptor STAT binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	240	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	241	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	242	R-HSA-9672159	STAT binds to p-11Y PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672159.md	STAT binds to p-11Y PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	243	R-HSA-9672176	STAT binds to the mutant PDGFRA receptor	yes	reactome/R-HSA-9672176.md	STAT binds to the mutant PDGFRA receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	244	R-HSA-9729454	SARS-CoV-2 N protein binds STAT1, STAT2	yes	reactome/R-HSA-9729454.md	SARS-CoV-2 N protein binds STAT1, STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	245	R-HSA-9835443	STAT1,STAT3 binds PKR	yes	reactome/R-HSA-9835443.md	STAT1,STAT3 binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	246	R-HSA-1112587	STAT1 and STAT3 dimers translocate to the nucleus	yes	reactome/R-HSA-1112587.md	STAT1 and STAT3 dimers translocate to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	247	R-HSA-6788623	p-Y-STATs translocate to nucleus	yes	reactome/R-HSA-6788623.md	p-Y-STATs translocate to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	248	R-HSA-8950522	p-STAT1:p-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950522.md	p-STAT1:p-STAT4 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	249	R-HSA-8950733	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	yes	reactome/R-HSA-8950733.md	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	250	R-HSA-9021334	STAT1 binds HEY1 gene promoter	yes	reactome/R-HSA-9021334.md	STAT1 binds HEY1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	254	R-HSA-1015699	ISGF3 binds the ISRE promoter elements in IFN-stimulated genes	yes	reactome/R-HSA-1015699.md	ISGF3 binds the ISRE promoter elements in IFN-stimulated genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	255	R-HSA-1031713	GAF binds the GAS promoter elements in the IFNG-regulated genes	yes	reactome/R-HSA-1031713.md	GAF binds the GAS promoter elements in the IFNG-regulated genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	256	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	257	R-HSA-873917	Translocation of STAT1 dimer to nucleus	yes	reactome/R-HSA-873917.md	Translocation of STAT1 dimer to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	258	R-HSA-877281	PIAS1 binds p-STAT1 dimer	yes	reactome/R-HSA-877281.md	PIAS1 binds p-STAT1 dimer	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	259	R-HSA-909721	Translocation of ISGF3 complex to nucleus	yes	reactome/R-HSA-909721.md	Translocation of ISGF3 complex to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	260	R-HSA-913529	Translocation of p-STAT1:p-STAT1 dimer to nucleus	yes	reactome/R-HSA-913529.md	Translocation of p-STAT1:p-STAT1 dimer to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	261	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	262	R-HSA-997326	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP	yes	reactome/R-HSA-997326.md	Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the nucleoplasm. STAT1 is genuinely present in the nucleoplasm as an active dimer/ISGF3, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	263	R-HSA-1112727	Serine phosphorylation of STATs	yes	reactome/R-HSA-1112727.md	Serine phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	264	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	265	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	266	R-HSA-873917	Translocation of STAT1 dimer to nucleus	yes	reactome/R-HSA-873917.md	Translocation of STAT1 dimer to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	267	R-HSA-873921	Binding of STAT1 to p-IFNGR1	yes	reactome/R-HSA-873921.md	Binding of STAT1 to p-IFNGR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	268	R-HSA-873922	Phosphorylation of STAT1 by JAK kinases	yes	reactome/R-HSA-873922.md	Phosphorylation of STAT1 by JAK kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	269	R-HSA-873927	Release of STAT1 dimer from active receptor unit	yes	reactome/R-HSA-873927.md	Release of STAT1 dimer from active receptor unit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	270	R-HSA-909552	Phosphorylation of STAT1 at Ser727	yes	reactome/R-HSA-909552.md	Phosphorylation of STAT1 at Ser727	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	271	R-HSA-909718	Formation of p-STAT1 homodimer	yes	reactome/R-HSA-909718.md	Formation of p-STAT1 homodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	272	R-HSA-909721	Translocation of ISGF3 complex to nucleus	yes	reactome/R-HSA-909721.md	Translocation of ISGF3 complex to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	273	R-HSA-909722	Release of p-STAT2:p-STAT1 dimer	yes	reactome/R-HSA-909722.md	Release of p-STAT2:p-STAT1 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	274	R-HSA-909725	Interaction of IRF9 with p-STAT2:p-STAT1	yes	reactome/R-HSA-909725.md	Interaction of IRF9 with p-STAT2:p-STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	275	R-HSA-909726	Phosphorylation of STAT1	yes	reactome/R-HSA-909726.md	Phosphorylation of STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	276	R-HSA-913529	Translocation of p-STAT1:p-STAT1 dimer to nucleus	yes	reactome/R-HSA-913529.md	Translocation of p-STAT1:p-STAT1 dimer to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	277	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	278	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	279	R-HSA-9710959	p-STAT1 dimer binds KPNA1	yes	reactome/R-HSA-9710959.md	p-STAT1 dimer binds KPNA1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	280	R-HSA-9710963	p-STAT1dimer:KPNA1 binds KPNB1	yes	reactome/R-HSA-9710963.md	p-STAT1dimer:KPNA1 binds KPNB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	281	R-HSA-997309	Dephosphorylation of STAT1 by SHP2	yes	reactome/R-HSA-997309.md	Dephosphorylation of STAT1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	282	R-HSA-1112538	Phosphorylated STAT1, STAT3 form dimers	yes	reactome/R-HSA-1112538.md	Phosphorylated STAT1, STAT3 form dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	283	R-HSA-1112587	STAT1 and STAT3 dimers translocate to the nucleus	yes	reactome/R-HSA-1112587.md	STAT1 and STAT3 dimers translocate to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	284	R-HSA-1112604	Phosphorylated STATs are released	yes	reactome/R-HSA-1112604.md	Phosphorylated STATs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	285	R-HSA-6788622	p-Y-STATs dimerize	yes	reactome/R-HSA-6788622.md	p-Y-STATs dimerize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	286	R-HSA-6788623	p-Y-STATs translocate to nucleus	yes	reactome/R-HSA-6788623.md	p-Y-STATs translocate to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	287	R-HSA-6788628	p-Y-STATs dissociate	yes	reactome/R-HSA-6788628.md	p-Y-STATs dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	288	R-HSA-8950733	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	yes	reactome/R-HSA-8950733.md	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT1	genes/human/STAT1/STAT1-ai-review.yaml	STAT1	P42224	NCBITaxon:9606	Homo sapiens	289	R-HSA-8950782	p-STAT1 binds p-STAT3	yes	reactome/R-HSA-8950782.md	p-STAT1 binds p-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Bulk Reactome reaction-participant annotation placing STAT1 in the cytosol. STAT1 is genuinely a latent cytosolic factor before activation, so the localization is correct, but this is one of many redundant per-reaction Reactome TAS rows for the same compartment.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	67	R-HSA-8986985	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	yes	reactome/R-HSA-8986985.md	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome type III IFN (IFNL) phosphorylation reaction. Correct but redundant reaction-level localization.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	68	R-HSA-8987033	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	yes	reactome/R-HSA-8987033.md	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNL dissociation reaction. Redundant reaction-level localization.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	73	R-HSA-1015699	ISGF3 binds the ISRE promoter elements in IFN-stimulated genes	yes	reactome/R-HSA-1015699.md	ISGF3 binds the ISRE promoter elements in IFN-stimulated genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from the Reactome ISGF3-binds-ISRE reaction. Correct; consistent with nuclear ISGF3 action.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	74	R-HSA-909721	Translocation of ISGF3 complex to nucleus	yes	reactome/R-HSA-909721.md	Translocation of ISGF3 complex to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization from the Reactome ISGF3 nuclear translocation reaction. Correct but redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	75	R-HSA-909718	Formation of p-STAT1 homodimer	yes	reactome/R-HSA-909718.md	Formation of p-STAT1 homodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFN signaling reaction. Redundant reaction-level localization.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	76	R-HSA-909721	Translocation of ISGF3 complex to nucleus	yes	reactome/R-HSA-909721.md	Translocation of ISGF3 complex to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome ISGF3 translocation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	77	R-HSA-909722	Release of p-STAT2:p-STAT1 dimer	yes	reactome/R-HSA-909722.md	Release of p-STAT2:p-STAT1 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome p-STAT2:p-STAT1 release reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	78	R-HSA-909725	Interaction of IRF9 with p-STAT2:p-STAT1	yes	reactome/R-HSA-909725.md	Interaction of IRF9 with p-STAT2:p-STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome IRF9-with-p-STAT2:p-STAT1 reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	79	R-HSA-909726	Phosphorylation of STAT1	yes	reactome/R-HSA-909726.md	Phosphorylation of STAT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome STAT1 phosphorylation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	80	R-HSA-909732	Phosphorylation of STAT2	yes	reactome/R-HSA-909732.md	Phosphorylation of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome STAT2 phosphorylation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	81	R-HSA-9710959	p-STAT1 dimer binds KPNA1	yes	reactome/R-HSA-9710959.md	p-STAT1 dimer binds KPNA1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome STAT1 dimer/KPNA1 reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	82	R-HSA-9710963	p-STAT1dimer:KPNA1 binds KPNB1	yes	reactome/R-HSA-9710963.md	p-STAT1dimer:KPNA1 binds KPNB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome STAT1 dimer:KPNA1:KPNB1 reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	83	R-HSA-997309	Dephosphorylation of STAT1 by SHP2	yes	reactome/R-HSA-997309.md	Dephosphorylation of STAT1 by SHP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome STAT1 dephosphorylation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	84	R-HSA-8987266	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	yes	reactome/R-HSA-8987266.md	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNL receptor binding reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	85	R-HSA-909719	Recruitment of STAT2 to p-IFNAR1	yes	reactome/R-HSA-909719.md	Recruitment of STAT2 to p-IFNAR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome STAT2-to-p-IFNAR1 recruitment reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	86	R-HSA-909720	IFN alpha/beta binds to IFNAR2	yes	reactome/R-HSA-909720.md	IFN alpha/beta binds to IFNAR2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFN/IFNAR2 binding reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	87	R-HSA-909724	Recruitment of IFNAR1	yes	reactome/R-HSA-909724.md	Recruitment of IFNAR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNAR1 recruitment reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	88	R-HSA-909729	Activation of JAK kinases	yes	reactome/R-HSA-909729.md	Activation of JAK kinases	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome JAK activation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	89	R-HSA-909730	Phosphorylation of INFAR1 by TYK2	yes	reactome/R-HSA-909730.md	Phosphorylation of INFAR1 by TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNAR1 phosphorylation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	90	R-HSA-9678935	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors	yes	reactome/R-HSA-9678935.md	IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNAR2:JAK1:STAT2 inhibitor reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	91	R-HSA-9696179	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs	yes	reactome/R-HSA-9696179.md	IFNAR2:JAK1:STAT2 binds type 1 interferon analogs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome IFNAR2:JAK1:STAT2 ligand-analog reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	92	R-HSA-9729454	SARS-CoV-2 N protein binds STAT1, STAT2	yes	reactome/R-HSA-9729454.md	SARS-CoV-2 N protein binds STAT1, STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome SARS-CoV-2-N-binds-STAT1/STAT2 reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	93	R-HSA-9833155	Ubiquitination of STAT2	yes	reactome/R-HSA-9833155.md	Ubiquitination of STAT2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome STAT2 ubiquitination reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	94	R-HSA-9920878	NS5 binds STAT2	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from the Reactome NS5-binds-STAT2 reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	95	R-HSA-997311	Dephosphorylation of TYK2 by PTP1B	yes	reactome/R-HSA-997311.md	Dephosphorylation of TYK2 by PTP1B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome TYK2 dephosphorylation reaction. Redundant.
human	STAT2	genes/human/STAT2/STAT2-ai-review.yaml	STAT2	P52630	NCBITaxon:9606	Homo sapiens	96	R-HSA-997314	Dephosphorylation of JAK1 by SHP1	yes	reactome/R-HSA-997314.md	Dephosphorylation of JAK1 by SHP1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization from a Reactome JAK1 dephosphorylation reaction. Redundant.
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	186	R-HSA-1112565	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	yes	reactome/R-HSA-1112565.md	Tyrosine phosphorylated IL6ST binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	187	R-HSA-1112602	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	yes	reactome/R-HSA-1112602.md	Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	188	R-HSA-1112727	Serine phosphorylation of STATs	yes	reactome/R-HSA-1112727.md	Serine phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	189	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	190	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	191	R-HSA-1888198	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3	yes	reactome/R-HSA-1888198.md	FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	192	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	193	R-HSA-452515	Expression of STAT3	yes	reactome/R-HSA-452515.md	Expression of STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	194	R-HSA-6784006	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	yes	reactome/R-HSA-6784006.md	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	195	R-HSA-6784323	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	yes	reactome/R-HSA-6784323.md	IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	196	R-HSA-6786095	JAK1 phosphorylates STAT3,STAT6	yes	reactome/R-HSA-6786095.md	JAK1 phosphorylates STAT3,STAT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	197	R-HSA-6786124	STAT3,STAT6 bind p-Y-IL4R	yes	reactome/R-HSA-6786124.md	STAT3,STAT6 bind p-Y-IL4R	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	198	R-HSA-6788571	STAT1,STAT3,STAT6 bind IL13:IL13R type II	yes	reactome/R-HSA-6788571.md	STAT1,STAT3,STAT6 bind IL13:IL13R type II	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	199	R-HSA-6788582	STAT1,STAT3,STAT6 phosphorylation	yes	reactome/R-HSA-6788582.md	STAT1,STAT3,STAT6 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	200	R-HSA-8848087	STAP2 recruits STAT3 to PTK6	yes	reactome/R-HSA-8848087.md	STAP2 recruits STAT3 to PTK6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	201	R-HSA-8848124	PTK6 phosphorylates STAT3	yes	reactome/R-HSA-8848124.md	PTK6 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	202	R-HSA-8875816	STAT3 binds activated MET receptor	yes	reactome/R-HSA-8875816.md	STAT3 binds activated MET receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	203	R-HSA-8875817	MET phosphorylates STAT3	yes	reactome/R-HSA-8875817.md	MET phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	204	R-HSA-8950269	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	yes	reactome/R-HSA-8950269.md	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	205	R-HSA-8950441	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	yes	reactome/R-HSA-8950441.md	p-Y701-STAT1 and p-Y705-STAT3 dissociate from IL27:IL27 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	206	R-HSA-8950485	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	yes	reactome/R-HSA-8950485.md	STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	207	R-HSA-8950518	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	yes	reactome/R-HSA-8950518.md	STAT1, STAT3 bind p-Y611-IL27RA from Interleukin-27:Interleukin-27 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	208	R-HSA-8952749	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	yes	reactome/R-HSA-8952749.md	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	209	R-HSA-8982163	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8982163.md	IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	210	R-HSA-8982165	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3	yes	reactome/R-HSA-8982165.md	IL19:IL20RA:p‑JAK1:IL20RB binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	211	R-HSA-8983059	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex	yes	reactome/R-HSA-8983059.md	STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	212	R-HSA-8983371	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	yes	reactome/R-HSA-8983371.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	213	R-HSA-8983378	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	yes	reactome/R-HSA-8983378.md	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	214	R-HSA-8984014	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	yes	reactome/R-HSA-8984014.md	JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	215	R-HSA-8984021	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984021.md	STAT1,STAT3 associate with IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	216	R-HSA-8985929	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	yes	reactome/R-HSA-8985929.md	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	217	R-HSA-8985988	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	yes	reactome/R-HSA-8985988.md	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	218	R-HSA-8986985	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	yes	reactome/R-HSA-8986985.md	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	219	R-HSA-8987014	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	yes	reactome/R-HSA-8987014.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	220	R-HSA-8987063	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3	yes	reactome/R-HSA-8987063.md	IL24:IL22RA1:p-JAK1:IL20RB binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	221	R-HSA-8987070	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987070.md	IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	222	R-HSA-8987080	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	yes	reactome/R-HSA-8987080.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1 binds STAT1, STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	223	R-HSA-8987096	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987096.md	IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	224	R-HSA-8987097	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	yes	reactome/R-HSA-8987097.md	IL24:p-IL20RA:p-JAK1:IL20RB binds STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	225	R-HSA-8987104	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3	yes	reactome/R-HSA-8987104.md	IL20:IL20RA:JAK1:IL20RB:p‑JAK2,p‑JAK3 binds STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	226	R-HSA-8987141	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3	yes	reactome/R-HSA-8987141.md	IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	227	R-HSA-8987150	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	yes	reactome/R-HSA-8987150.md	IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	228	R-HSA-8987255	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	yes	reactome/R-HSA-8987255.md	IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	229	R-HSA-8987266	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	yes	reactome/R-HSA-8987266.md	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	230	R-HSA-9006870	IL21 receptor STAT phosphorylation	yes	reactome/R-HSA-9006870.md	IL21 receptor STAT phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	231	R-HSA-9006873	IL21 receptor STAT binding	yes	reactome/R-HSA-9006873.md	IL21 receptor STAT binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	232	R-HSA-9009072	STAT3 phosphorylation	yes	reactome/R-HSA-9009072.md	STAT3 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	233	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	234	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	235	R-HSA-9672159	STAT binds to p-11Y PDGFRA extracellular domain dimers	yes	reactome/R-HSA-9672159.md	STAT binds to p-11Y PDGFRA extracellular domain dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	236	R-HSA-9672176	STAT binds to the mutant PDGFRA receptor	yes	reactome/R-HSA-9672176.md	STAT binds to the mutant PDGFRA receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	237	R-HSA-9701524	STAT3 is phosphorylated downstream of active ALK	yes	reactome/R-HSA-9701524.md	STAT3 is phosphorylated downstream of active ALK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	238	R-HSA-9701525	p-Y705,S727-STAT3 dimerizes	yes	reactome/R-HSA-9701525.md	p-Y705,S727-STAT3 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	239	R-HSA-9701529	p-Y705, p-S727 STAT3 dimer translocates to the nucleus	yes	reactome/R-HSA-9701529.md	p-Y705, p-S727 STAT3 dimer translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	240	R-HSA-9712079	ALK mutants bind STAT3	yes	reactome/R-HSA-9712079.md	ALK mutants bind STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	241	R-HSA-9712085	ALK mutants phosphorylate STAT3	yes	reactome/R-HSA-9712085.md	ALK mutants phosphorylate STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	242	R-HSA-9835443	STAT1,STAT3 binds PKR	yes	reactome/R-HSA-9835443.md	STAT1,STAT3 binds PKR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	243	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	244	R-HSA-9851142	TYK2-dependent STAT1 and STAT3 phosphorylation	yes	reactome/R-HSA-9851142.md	TYK2-dependent STAT1 and STAT3 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	285	R-HSA-9701529	p-Y705, p-S727 STAT3 dimer translocates to the nucleus	yes	reactome/R-HSA-9701529.md	p-Y705, p-S727 STAT3 dimer translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	286	R-HSA-9701531	p-Y705,S727 STAT3 is acetylated	yes	reactome/R-HSA-9701531.md	p-Y705,S727 STAT3 is acetylated	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	287	R-HSA-9701534	p-Y705, S727 STAT3 dimer binds HIF1A gene	yes	reactome/R-HSA-9701534.md	p-Y705, S727 STAT3 dimer binds HIF1A gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	288	R-HSA-9701537	p-Y705, S727 STAT3 dimer binds CD274 gene	yes	reactome/R-HSA-9701537.md	p-Y705, S727 STAT3 dimer binds CD274 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	289	R-HSA-9701549	AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter	yes	reactome/R-HSA-9701549.md	AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	290	R-HSA-9701557	AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter	yes	reactome/R-HSA-9701557.md	AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	291	R-HSA-9701565	HDACs deacetylate p-STAT3 dimers	yes	reactome/R-HSA-9701565.md	HDACs deacetylate p-STAT3 dimers	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	292	R-HSA-9850958	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	yes	reactome/R-HSA-9850958.md	pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	293	R-HSA-9851058	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene	yes	reactome/R-HSA-9851058.md	AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	294	R-HSA-9851062	AcK685 pY705,S727 STAT3 binds the MIR21 gene	yes	reactome/R-HSA-9851062.md	AcK685 pY705,S727 STAT3 binds the MIR21 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	295	R-HSA-9851064	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter	yes	reactome/R-HSA-9851064.md	AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	296	R-HSA-9851071	STAT3, DNMT1 and HDAC1 bind PTPN6 gene	yes	reactome/R-HSA-9851071.md	STAT3, DNMT1 and HDAC1 bind PTPN6 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	297	R-HSA-9851106	p-Y705, S727 STAT3 dimer binds ICOS promoter	yes	reactome/R-HSA-9851106.md	p-Y705, S727 STAT3 dimer binds ICOS promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	298	R-HSA-9851118	pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK	yes	reactome/R-HSA-9851118.md	pY-STAT3 binds the IRF4 promoter downstream of NPM1-ALK	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	299	R-HSA-9851122	p-Y705,S727 STAT3 dimer binds NOTCH gene	yes	reactome/R-HSA-9851122.md	p-Y705,S727 STAT3 dimer binds NOTCH gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	320	R-HSA-8983379	p-Y-STAT3:p-STAT5 translocates to the nucleus	yes	reactome/R-HSA-8983379.md	p-Y-STAT3:p-STAT5 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	321	R-HSA-8985981	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985981.md	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	322	R-HSA-8983373	p-Y-STAT3 binds p-STAT5	yes	reactome/R-HSA-8983373.md	p-Y-STAT3 binds p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	323	R-HSA-8983374	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	yes	reactome/R-HSA-8983374.md	p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	324	R-HSA-8983379	p-Y-STAT3:p-STAT5 translocates to the nucleus	yes	reactome/R-HSA-8983379.md	p-Y-STAT3:p-STAT5 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	325	R-HSA-8985966	p-Y701-STAT1 binds p-Y705-STAT3	yes	reactome/R-HSA-8985966.md	p-Y701-STAT1 binds p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	326	R-HSA-8985981	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	yes	reactome/R-HSA-8985981.md	p-Y701-STAT1:p-Y705-STAT3 translocates from the cytosol to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	327	R-HSA-8983078	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex	yes	reactome/R-HSA-8983078.md	p-STAT3 dissociates from TSLP:IL7R:CRLF2:p-STAT3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	328	R-HSA-8984023	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	yes	reactome/R-HSA-8984023.md	p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	329	R-HSA-8987033	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	yes	reactome/R-HSA-8987033.md	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	330	R-HSA-8987052	p-STAT3 dimer translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8987052.md	p-STAT3 dimer translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	331	R-HSA-8987156	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3	yes	reactome/R-HSA-8987156.md	p-STAT3 dissociates from IL20:IL20RA:JAK1:IL20RB:p-Y1007,Y1008-JAK2,p-JAK3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	332	R-HSA-8987161	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3	yes	reactome/R-HSA-8987161.md	p-STAT3 dissociates from IL24:IL22RA1:p‑JAK1:IL20RB:p‑STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	333	R-HSA-8987214	p-STAT3 dimerizes	yes	reactome/R-HSA-8987214.md	p-STAT3 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	334	R-HSA-8987230	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	yes	reactome/R-HSA-8987230.md	p-STAT1 and p-STAT3 dissociates from IL26:IL10RB:p-TYK2:IL20RA:p-JAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	335	R-HSA-8987270	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	yes	reactome/R-HSA-8987270.md	p-STAT1,p-STAT3 dissociate from IL24:IL20RA:p-Y1022,Y1023-JAK1:IL20RB:p-STAT1, p-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	336	R-HSA-8987052	p-STAT3 dimer translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-8987052.md	p-STAT3 dimer translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	367	R-HSA-1112538	Phosphorylated STAT1, STAT3 form dimers	yes	reactome/R-HSA-1112538.md	Phosphorylated STAT1, STAT3 form dimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	368	R-HSA-1112587	STAT1 and STAT3 dimers translocate to the nucleus	yes	reactome/R-HSA-1112587.md	STAT1 and STAT3 dimers translocate to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	369	R-HSA-1112604	Phosphorylated STATs are released	yes	reactome/R-HSA-1112604.md	Phosphorylated STATs are released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	370	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	371	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	372	R-HSA-6784763	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-6784763.md	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	373	R-HSA-6784765	p-Y705-STAT3 dimerizes	yes	reactome/R-HSA-6784765.md	p-Y705-STAT3 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	374	R-HSA-6784791	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-6784791.md	p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	375	R-HSA-6786072	p-Y705-STAT3,p-Y641-STAT6 dissociate	yes	reactome/R-HSA-6786072.md	p-Y705-STAT3,p-Y641-STAT6 dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	376	R-HSA-6786097	p-Y705-STAT3, p-Y641-STAT6 dimerise	yes	reactome/R-HSA-6786097.md	p-Y705-STAT3, p-Y641-STAT6 dimerise	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	377	R-HSA-6786293	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus	yes	reactome/R-HSA-6786293.md	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	378	R-HSA-6788622	p-Y-STATs dimerize	yes	reactome/R-HSA-6788622.md	p-Y-STATs dimerize	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	379	R-HSA-6788623	p-Y-STATs translocate to nucleus	yes	reactome/R-HSA-6788623.md	p-Y-STATs translocate to nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	380	R-HSA-6788628	p-Y-STATs dissociate	yes	reactome/R-HSA-6788628.md	p-Y-STATs dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	381	R-HSA-8950724	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950724.md	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	382	R-HSA-8950733	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	yes	reactome/R-HSA-8950733.md	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	383	R-HSA-8950780	p-Y705-STAT3 binds p-Y693-STAT4	yes	reactome/R-HSA-8950780.md	p-Y705-STAT3 binds p-Y693-STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	384	R-HSA-8950782	p-STAT1 binds p-STAT3	yes	reactome/R-HSA-8950782.md	p-STAT1 binds p-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	385	R-HSA-8952823	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	yes	reactome/R-HSA-8952823.md	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	386	R-HSA-8982162	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB	yes	reactome/R-HSA-8982162.md	p‑Y705-STAT3 dissociates from IL19:IL20RA:p-JAK1:IL20RB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	387	R-HSA-8985900	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	yes	reactome/R-HSA-8985900.md	p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	388	R-HSA-8987236	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	yes	reactome/R-HSA-8987236.md	p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	389	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	390	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization of latent STAT3 [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	393	R-HSA-1112587	STAT1 and STAT3 dimers translocate to the nucleus	yes	reactome/R-HSA-1112587.md	STAT1 and STAT3 dimers translocate to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	394	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	395	R-HSA-2895778	POU5F1 (OCT4), STAT3 bind the SALL4 promoter	yes	reactome/R-HSA-2895778.md	POU5F1 (OCT4), STAT3 bind the SALL4 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	396	R-HSA-6784763	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm	yes	reactome/R-HSA-6784763.md	p-Y705-STAT3 dimer translocates from cytosol to nucleoplasm	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	397	R-HSA-6786293	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus	yes	reactome/R-HSA-6786293.md	p-Y705-STAT3 dimer, p-Y641-STAT6 dimer translocate to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	398	R-HSA-6788623	p-Y-STATs translocate to nucleus	yes	reactome/R-HSA-6788623.md	p-Y-STATs translocate to nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	399	R-HSA-8848150	STAT3 binds SOCS3 promoter	yes	reactome/R-HSA-8848150.md	STAT3 binds SOCS3 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	400	R-HSA-8950724	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950724.md	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	401	R-HSA-8950733	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	yes	reactome/R-HSA-8950733.md	p-Y701-STAT1:p-Y705-STAT3 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT3	genes/human/STAT3/STAT3-ai-review.yaml	STAT3	P40763	NCBITaxon:9606	Homo sapiens	402	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization of activated STAT3 dimers [file:human/STAT3/STAT3-deep-research-falcon.md]
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	40	R-HSA-8950269	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	yes	reactome/R-HSA-8950269.md	STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome IL-23 signaling pathway (STAT4 phosphorylation by JAK2/TYK2 in IL23 receptor complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	41	R-HSA-8950448	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex	yes	reactome/R-HSA-8950448.md	STAT4 binds to IL12RB2 in Interleukin-12 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT4 binds IL12RB2 in IL-12 receptor complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	42	R-HSA-8950453	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	yes	reactome/R-HSA-8950453.md	JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (JAK1/JAK2 phosphorylates STAT1 and STAT4 at IL12RB2:IL6ST receptor).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	43	R-HSA-8950522	p-STAT1:p-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950522.md	p-STAT1:p-STAT4 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT1:p-STAT4 translocates to the nucleus). This Reactome event represents the starting point (cytosol) of the translocation.
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	44	R-HSA-8952749	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	yes	reactome/R-HSA-8952749.md	STAT4 binds p-Y-IL23R in IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT4 binds p-Y-IL23R in IL23 receptor complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	45	R-HSA-8983872	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4	yes	reactome/R-HSA-8983872.md	JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (JAK2 phosphorylates STAT4 at IL12RB2 homodimer).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	46	R-HSA-8983876	STAT4 binds IL12RB2:IL12RB2	yes	reactome/R-HSA-8983876.md	STAT4 binds IL12RB2:IL12RB2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT4 binds IL12RB2 homodimer).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	47	R-HSA-8983878	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor	yes	reactome/R-HSA-8983878.md	p-STAT4 dissociates from IL12RB2:IL12RB2 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT4 dissociates from IL12RB2 homodimer).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	48	R-HSA-8983983	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983983.md	p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT1 and p-STAT4 dissociate from IL12RB2:IL6ST receptor).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	49	R-HSA-8983996	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	yes	reactome/R-HSA-8983996.md	STAT1 and STAT4 associate with IL12RB2:IL6ST receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT1 and STAT4 associate with IL12RB2:IL6ST receptor).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	50	R-HSA-8986985	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	yes	reactome/R-HSA-8986985.md	IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (IFN-lambda signaling: STAT4 among STATs phosphorylated by the IFNLR complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	51	R-HSA-8987033	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL receptor complex	yes	reactome/R-HSA-8987033.md	p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT4 dissociates from IFN-lambda receptor complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	52	R-HSA-8987266	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	yes	reactome/R-HSA-8987266.md	IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT4 among STATs binding to IFN-lambda receptor complex).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	53	R-HSA-9006870	IL21 receptor STAT phosphorylation	yes	reactome/R-HSA-9006870.md	IL21 receptor STAT phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (IL-21 receptor STAT phosphorylation).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	54	R-HSA-9006873	IL21 receptor STAT binding	yes	reactome/R-HSA-9006873.md	IL21 receptor STAT binding	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (IL-21 receptor STAT binding).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	55	R-HSA-8950181	p-Y693-STAT4 dimer translocates to the nucleus	yes	reactome/R-HSA-8950181.md	p-Y693-STAT4 dimer translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome (p-Y693-STAT4 dimer translocates to the nucleus).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	56	R-HSA-8950522	p-STAT1:p-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950522.md	p-STAT1:p-STAT4 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome (p-STAT1:p-STAT4 translocates to the nucleus). The STAT1:STAT4 heterodimer enters the nucleoplasm.
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	57	R-HSA-8950724	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950724.md	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization from Reactome (p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus). The STAT3:STAT4 heterodimer enters the nucleoplasm.
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	58	R-HSA-8950181	p-Y693-STAT4 dimer translocates to the nucleus	yes	reactome/R-HSA-8950181.md	p-Y693-STAT4 dimer translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-Y693-STAT4 dimer translocates to the nucleus - starting compartment is cytosol).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	59	R-HSA-8950724	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	yes	reactome/R-HSA-8950724.md	p-Y705-STAT3:p-Y693-STAT4 translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (STAT3:STAT4 heterodimer translocation - starting compartment).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	60	R-HSA-8950778	p-Y693-STAT4 dimerizes	yes	reactome/R-HSA-8950778.md	p-Y693-STAT4 dimerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-Y693-STAT4 dimerizes in the cytosol).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	61	R-HSA-8950780	p-Y705-STAT3 binds p-Y693-STAT4	yes	reactome/R-HSA-8950780.md	p-Y705-STAT3 binds p-Y693-STAT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT3 binds p-STAT4 in the cytosol to form the STAT3:STAT4 heterodimer).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	62	R-HSA-8952807	p-Y693-STAT4 dissociates after IL12:IL12R interaction	yes	reactome/R-HSA-8952807.md	p-Y693-STAT4 dissociates after IL12:IL12R interaction	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT4 dissociates after IL12:IL12R interaction).
human	STAT4	genes/human/STAT4/STAT4-ai-review.yaml	STAT4	Q14765	NCBITaxon:9606	Homo sapiens	63	R-HSA-8952823	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	yes	reactome/R-HSA-8952823.md	p-Y693-STAT4, p-Y705-STAT3 dissociate from IL23:IL23 receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome (p-STAT4, p-STAT3 dissociate from IL23 receptor).
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	33	R-HSA-1254285	ERBB4s80:STAT5A complex translocates to the nucleus	yes	reactome/R-HSA-1254285.md	ERBB4s80:STAT5A complex translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	34	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	35	R-HSA-8954224	ERBB4s80:STAT5A binds CSN2 gene promoter	yes	reactome/R-HSA-8954224.md	ERBB4s80:STAT5A binds CSN2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	36	R-HSA-8983379	p-Y-STAT3:p-STAT5 translocates to the nucleus	yes	reactome/R-HSA-8983379.md	p-Y-STAT3:p-STAT5 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	37	R-HSA-9012671	p-STAT5 binds CISH, SOCS1 and SOCS2 gene	yes	reactome/R-HSA-9012671.md	p-STAT5 binds CISH, SOCS1 and SOCS2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	38	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	39	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	40	R-HSA-9698021	PTPN11:p-STAT5 binds BCL2L1 promoter	yes	reactome/R-HSA-9698021.md	PTPN11:p-STAT5 binds BCL2L1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	41	R-HSA-9698033	p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698033.md	p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	42	R-HSA-9698041	p-STAT5 binds the CDKN1A gene	yes	reactome/R-HSA-9698041.md	p-STAT5 binds the CDKN1A gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	43	R-HSA-9698754	p-STAT5 binds the NOX4 promoter	yes	reactome/R-HSA-9698754.md	p-STAT5 binds the NOX4 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	44	R-HSA-9701903	ALK-, STAT3- and MECP2-dependent STAT5A gene repression	yes	reactome/R-HSA-9701903.md	ALK-, STAT3- and MECP2-dependent STAT5A gene repression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	45	R-HSA-9978250	Phosphorylated STAT5 dimer binds the IL4R gene	yes	reactome/R-HSA-9978250.md	Phosphorylated STAT5 dimer binds the IL4R gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	50	R-HSA-1168894	p-STAT5A/B dissociates from the Growth Hormone receptor	yes	reactome/R-HSA-1168894.md	p-STAT5A/B dissociates from the Growth Hormone receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	51	R-HSA-1254285	ERBB4s80:STAT5A complex translocates to the nucleus	yes	reactome/R-HSA-1254285.md	ERBB4s80:STAT5A complex translocates to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	52	R-HSA-1254291	ERBB4s80 binds STAT5A	yes	reactome/R-HSA-1254291.md	ERBB4s80 binds STAT5A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	53	R-HSA-1295540	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	yes	reactome/R-HSA-1295540.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	54	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	55	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	56	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	57	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	58	R-HSA-1839112	Phosphorylation of STAT5 by cytosolic FGFR1 fusions	yes	reactome/R-HSA-1839112.md	Phosphorylation of STAT5 by cytosolic FGFR1 fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	59	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	60	R-HSA-452097	Recruited STAT5 is phosphorylated	yes	reactome/R-HSA-452097.md	Recruited STAT5 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	61	R-HSA-452108	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	yes	reactome/R-HSA-452108.md	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	62	R-HSA-6785165	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	yes	reactome/R-HSA-6785165.md	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	63	R-HSA-879909	Activation of STAT5a/b by JAK2	yes	reactome/R-HSA-879909.md	Activation of STAT5a/b by JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	64	R-HSA-879930	STAT5 is recruited by JAK2	yes	reactome/R-HSA-879930.md	STAT5 is recruited by JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	65	R-HSA-8985929	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	yes	reactome/R-HSA-8985929.md	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	66	R-HSA-8985988	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	yes	reactome/R-HSA-8985988.md	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	67	R-HSA-9025969	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	yes	reactome/R-HSA-9025969.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	68	R-HSA-919404	Phosphorylated STAT5 is released	yes	reactome/R-HSA-919404.md	Phosphorylated STAT5 is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	69	R-HSA-921155	p-STAT5 dissociates from the receptor complex	yes	reactome/R-HSA-921155.md	p-STAT5 dissociates from the receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	70	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	71	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	72	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	73	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	74	R-HSA-9698005	FLT3 ITD mutants phosphorylate STAT5	yes	reactome/R-HSA-9698005.md	FLT3 ITD mutants phosphorylate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	75	R-HSA-9698013	PTPN11:p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698013.md	PTPN11:p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	76	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	77	R-HSA-9698029	p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698029.md	p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	78	R-HSA-9698033	p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698033.md	p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	79	R-HSA-9703432	p-STAT5 dissociates from FLT3 fusion proteinsp-	yes	reactome/R-HSA-9703432.md	p-STAT5 dissociates from FLT3 fusion proteinsp-	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5A	genes/human/STAT5A/STAT5A-ai-review.yaml	STAT5A	P42229	NCBITaxon:9606	Homo sapiens	80	R-HSA-9703435	FLT3 fusions activate STAT5	yes	reactome/R-HSA-9703435.md	FLT3 fusions activate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5A within a Reactome cytokine/hormone signaling pathway. Consistent with the core cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	52	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	53	R-HSA-8983379	p-Y-STAT3:p-STAT5 translocates to the nucleus	yes	reactome/R-HSA-8983379.md	p-Y-STAT3:p-STAT5 translocates to the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	54	R-HSA-9012671	p-STAT5 binds CISH, SOCS1 and SOCS2 gene	yes	reactome/R-HSA-9012671.md	p-STAT5 binds CISH, SOCS1 and SOCS2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	55	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	56	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	57	R-HSA-9698021	PTPN11:p-STAT5 binds BCL2L1 promoter	yes	reactome/R-HSA-9698021.md	PTPN11:p-STAT5 binds BCL2L1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	58	R-HSA-9698033	p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698033.md	p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	59	R-HSA-9698041	p-STAT5 binds the CDKN1A gene	yes	reactome/R-HSA-9698041.md	p-STAT5 binds the CDKN1A gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	60	R-HSA-9698754	p-STAT5 binds the NOX4 promoter	yes	reactome/R-HSA-9698754.md	p-STAT5 binds the NOX4 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	61	R-HSA-9978250	Phosphorylated STAT5 dimer binds the IL4R gene	yes	reactome/R-HSA-9978250.md	Phosphorylated STAT5 dimer binds the IL4R gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization of activated STAT5B within Reactome cytokine/hormone signaling pathways. Consistent with the IDA nucleus annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	62	R-HSA-1168894	p-STAT5A/B dissociates from the Growth Hormone receptor	yes	reactome/R-HSA-1168894.md	p-STAT5A/B dissociates from the Growth Hormone receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	63	R-HSA-1295540	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	yes	reactome/R-HSA-1295540.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	64	R-HSA-1470009	Phosphorylation of STATs	yes	reactome/R-HSA-1470009.md	Phosphorylation of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	65	R-HSA-1470010	Dimerization of STATs	yes	reactome/R-HSA-1470010.md	Dimerization of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	66	R-HSA-1470012	Disassociation and translocation of STATs to the nucleus	yes	reactome/R-HSA-1470012.md	Disassociation and translocation of STATs to the nucleus	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	67	R-HSA-1839112	Phosphorylation of STAT5 by cytosolic FGFR1 fusions	yes	reactome/R-HSA-1839112.md	Phosphorylation of STAT5 by cytosolic FGFR1 fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	68	R-HSA-452097	Recruited STAT5 is phosphorylated	yes	reactome/R-HSA-452097.md	Recruited STAT5 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	69	R-HSA-6785165	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	yes	reactome/R-HSA-6785165.md	p-STAT5A, p-STAT5B dissociate from IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:p-STAT5A,p-STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	70	R-HSA-879909	Activation of STAT5a/b by JAK2	yes	reactome/R-HSA-879909.md	Activation of STAT5a/b by JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	71	R-HSA-919404	Phosphorylated STAT5 is released	yes	reactome/R-HSA-919404.md	Phosphorylated STAT5 is released	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	72	R-HSA-921155	p-STAT5 dissociates from the receptor complex	yes	reactome/R-HSA-921155.md	p-STAT5 dissociates from the receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	73	R-HSA-9670412	Phosphorylation of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670412.md	Phosphorylation of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	74	R-HSA-9670417	Dimerization of STATs downstream of KIT mutants	yes	reactome/R-HSA-9670417.md	Dimerization of STATs downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	75	R-HSA-9670426	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	yes	reactome/R-HSA-9670426.md	Disassociation and translocation of STATs to the nucleus downstream of KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	76	R-HSA-9698005	FLT3 ITD mutants phosphorylate STAT5	yes	reactome/R-HSA-9698005.md	FLT3 ITD mutants phosphorylate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	77	R-HSA-9698013	PTPN11:p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698013.md	PTPN11:p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	78	R-HSA-9698016	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698016.md	PTPN11:p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	79	R-HSA-9698029	p-STAT5 dissociates from mutant FLT3	yes	reactome/R-HSA-9698029.md	p-STAT5 dissociates from mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	80	R-HSA-9698033	p-STAT5 translocates to nucleus downstream of mutant FLT3	yes	reactome/R-HSA-9698033.md	p-STAT5 translocates to nucleus downstream of mutant FLT3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	81	R-HSA-9703432	p-STAT5 dissociates from FLT3 fusion proteinsp-	yes	reactome/R-HSA-9703432.md	p-STAT5 dissociates from FLT3 fusion proteinsp-	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	82	R-HSA-9703435	FLT3 fusions activate STAT5	yes	reactome/R-HSA-9703435.md	FLT3 fusions activate STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	84	R-HSA-1433456	Recruitment of STATs	yes	reactome/R-HSA-1433456.md	Recruitment of STATs	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	85	R-HSA-380782	STAT binds to the active receptor	yes	reactome/R-HSA-380782.md	STAT binds to the active receptor	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	86	R-HSA-452108	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	yes	reactome/R-HSA-452108.md	Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	87	R-HSA-879930	STAT5 is recruited by JAK2	yes	reactome/R-HSA-879930.md	STAT5 is recruited by JAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	88	R-HSA-8985929	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	yes	reactome/R-HSA-8985929.md	IL9:p-Y407-IL9R:JAK1:IL2RG:p-904,939-JAK3 binds STAT1, STAT3, STAT5A or STAT5B	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	89	R-HSA-8985988	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	yes	reactome/R-HSA-8985988.md	IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:STAT3 phosphorylates STAT1, STAT3 or STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	90	R-HSA-9025969	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	yes	reactome/R-HSA-9025969.md	IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3 binds STAT5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STAT5B	genes/human/STAT5B/STAT5B-ai-review.yaml	STAT5B	P51692	NCBITaxon:9606	Homo sapiens	91	R-HSA-9670416	Recruitment of STATs by KIT mutants	yes	reactome/R-HSA-9670416.md	Recruitment of STATs by KIT mutants	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic localization of latent STAT5B within a Reactome cytokine/hormone signaling pathway. Consistent with the IDA cytoplasm annotation; one of many pathway-specific Reactome localization records.
human	STBD1	genes/human/STBD1/STBD1-ai-review.yaml	STBD1	O95210	NCBITaxon:9606	Homo sapiens	34	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane; the parent under which the sarcolemma/T-tubule observation sits.
human	STBD1	genes/human/STBD1/STBD1-ai-review.yaml	STBD1	O95210	NCBITaxon:9606	Homo sapiens	35	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Plasma membrane; the parent under which the sarcolemma/T-tubule observation sits.
human	STBD1	genes/human/STBD1/STBD1-ai-review.yaml	STBD1	O95210	NCBITaxon:9606	Homo sapiens	36	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Tertiary granule membrane, from neutrophil organelle proteomics.
human	STBD1	genes/human/STBD1/STBD1-ai-review.yaml	STBD1	O95210	NCBITaxon:9606	Homo sapiens	37	R-HSA-6800426	Exocytosis of ficolin-rich granule membrane proteins	yes	reactome/R-HSA-6800426.md	Exocytosis of ficolin-rich granule membrane proteins	Homo sapiens	GO:0101003	ficolin-1-rich granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Ficolin-1-rich granule membrane, from the same neutrophil proteomics series.
human	STC2	genes/human/STC2/STC2-ai-review.yaml	STC2	O76061	NCBITaxon:9606	Homo sapiens	13	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	STC2 localizes to the ER lumen as part of the secretory pathway. This annotation from Reactome reflects STC2 being a substrate of FAM20C, an extracellular/Golgi kinase that phosphorylates secreted proteins. STC2 is phosphorylated at Ser-250, Ser-251, and Thr-254 by FAM20C (UniProt). The ER lumen localization is consistent with STC2 having a signal peptide and transiting through the ER-Golgi secretory pathway.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	152	R-HSA-3244626	DENV protease NS2B3 cleaves STING	yes	reactome/R-HSA-3244626.md	DENV protease NS2B3 cleaves STING	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	STING1 is an integral membrane protein; only its C-terminal ligand-binding and signalling domain faces the cytosol.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	178	R-HSA-1964496	STING binds TRIM32 or TRIM56	yes	reactome/R-HSA-1964496.md	STING binds TRIM32 or TRIM56	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	179	R-HSA-2396009	STING binds c-di-GMP	yes	reactome/R-HSA-2396009.md	STING binds c-di-GMP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	180	R-HSA-3134800	STING dimerization	yes	reactome/R-HSA-3134800.md	STING dimerization	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	181	R-HSA-3134804	STING ubiquitination by TRIM32 or TRIM56	yes	reactome/R-HSA-3134804.md	STING ubiquitination by TRIM32 or TRIM56	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	182	R-HSA-3244618	DENV protease NS2B3 binds STING	yes	reactome/R-HSA-3244618.md	DENV protease NS2B3 binds STING	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	183	R-HSA-3244626	DENV protease NS2B3 cleaves STING	yes	reactome/R-HSA-3244626.md	DENV protease NS2B3 cleaves STING	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	184	R-HSA-3244643	STING binds cyclic GMP-AMP	yes	reactome/R-HSA-3244643.md	STING binds cyclic GMP-AMP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	185	R-HSA-9711016	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING	yes	reactome/R-HSA-9711016.md	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	186	R-HSA-9730501	SARS-CoV-2 3CLpro dimer binds to STING	yes	reactome/R-HSA-9730501.md	SARS-CoV-2 3CLpro dimer binds to STING	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	187	R-HSA-9730528	SARS-CoV-2 3a binds to STING	yes	reactome/R-HSA-9730528.md	SARS-CoV-2 3a binds to STING	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	The endoplasmic reticulum membrane is where resting STING1 resides and where it is activated by cGAMP before ER exit.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	218	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Plasma membrane localisation has no human experimental support and is contradicted by the trafficking literature.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	219	R-HSA-6798743	Exocytosis of secretory granule membrane proteins	yes	reactome/R-HSA-6798743.md	Exocytosis of secretory granule membrane proteins	Homo sapiens	GO:0030667	secretory granule membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	A single TAS row from a generic Reactome neutrophil-degranulation reaction.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	223	R-HSA-1834939	STING recruits TBK1 and IRF3	yes	reactome/R-HSA-1834939.md	STING recruits TBK1 and IRF3	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	224	R-HSA-2396002	TBK1 is phosphorylated within STING:TBK1:IRF3 complex	yes	reactome/R-HSA-2396002.md	TBK1 is phosphorylated within STING:TBK1:IRF3 complex	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	225	R-HSA-2396007	IRF3 is phosphorylated by TBK1	yes	reactome/R-HSA-2396007.md	IRF3 is phosphorylated by TBK1	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	226	R-HSA-2396009	STING binds c-di-GMP	yes	reactome/R-HSA-2396009.md	STING binds c-di-GMP	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	227	R-HSA-3244643	STING binds cyclic GMP-AMP	yes	reactome/R-HSA-3244643.md	STING binds cyclic GMP-AMP	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	228	R-HSA-3249371	TBK1 phosphorylates STAT6 at Ser407	yes	reactome/R-HSA-3249371.md	TBK1 phosphorylates STAT6 at Ser407	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	229	R-HSA-3249378	STING recruits TBK1 and STAT6	yes	reactome/R-HSA-3249378.md	STING recruits TBK1 and STAT6	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	230	R-HSA-3249390	TBK1 is phosphorylated within STING:TBK1:STAT6 complex	yes	reactome/R-HSA-3249390.md	TBK1 is phosphorylated within STING:TBK1:STAT6 complex	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	231	R-HSA-3249392	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3	yes	reactome/R-HSA-3249392.md	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STING1	genes/human/STING1/STING1-ai-review.yaml	STING1	Q86WV6	NCBITaxon:9606	Homo sapiens	232	R-HSA-8948709	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3	yes	reactome/R-HSA-8948709.md	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3	Homo sapiens	GO:0030659	cytoplasmic vesicle membrane	TAS	located_in	CC	false		MODIFY	These ten Reactome-derived rows describe the post-ER vesicular compartment that is now identified specifically as the ERGIC.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	28	R-HSA-3371503	HSF1 activation / cytosolic chaperone pathway	yes	reactome/R-HSA-3371503.md	STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	29	R-HSA-5618085	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-5618085.md	FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	30	R-HSA-5618098	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-5618098.md	p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	31	R-HSA-5618105	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-5618105.md	FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	32	R-HSA-5618107	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-5618107.md	ATP binding to HSP90 triggers conformation change	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	33	R-HSA-5618110	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-5618110.md	p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STIP1	genes/human/STIP1/STIP1-ai-review.yaml	STIP1	P31948	NCBITaxon:9606	Homo sapiens	34	R-HSA-9696271	Cytosolic chaperone (HSP90) pathway	yes	reactome/R-HSA-9696271.md	RND1 binds effectors	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated (Reactome) cytosolic localization, consistent with HOP's cytoplasmic chaperone role.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	30	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Stomatin localizes to neutrophil azurophil granule membranes according to Reactome annotation for neutrophil degranulation pathway.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Stomatin localizes to neutrophil specific granule membranes according to Reactome.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	32	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Stomatin localizes to neutrophil tertiary granule membranes according to Reactome.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	33	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome. Redundant with other PM annotations.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	34	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome. Redundant with other PM annotations.
human	STOM	genes/human/STOM/STOM-ai-review.yaml	STOM	P27105	NCBITaxon:9606	Homo sapiens	35	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome. Redundant with other PM annotations.
human	STOML3	genes/human/STOML3/STOML3-ai-review.yaml	STOML3	Q8TAV4	NCBITaxon:9606	Homo sapiens	10	R-HSA-8863494	ASICs bind STOML3, (STOM)	yes	reactome/R-HSA-8863494.md	ASICs bind STOML3, (STOM)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Plasma membrane localization from Reactome pathway curation documenting ASIC binding to STOML3 and stomatin at the plasma membrane.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	18	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	TAS	enables	MF	false		ACCEPT	Reactome-curated (TAS) assignment of the core catalytic activity, in the context of CDH1 (E-cadherin) N-glycosylation in the ER. This is STT3A's own correct core molecular function.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	39	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	"Reactome-curated (TAS) ER membrane location for STT3A in the ""Transfer of N-glycan to the protein"" reaction. Correct core cellular location."
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	40	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in a viral (spike protein) N-glycosylation reaction. Correct core location; the substrate context is viral but the STT3A localization is accurate.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	41	R-HSA-9816276	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	yes	reactome/R-HSA-9816276.md	CDH1 is N-glycosylated on asparagine residues in endoplasmic reticulum	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in the CDH1 N-glycosylation reaction. Correct core location.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	42	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in a viral (E protein) N-glycosylation reaction. Correct core location.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	43	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in a viral (pre-M protein) N-glycosylation reaction. Correct core location.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	44	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in a viral (pre-NS1 protein) N-glycosylation reaction. Correct core location.
human	STT3A	genes/human/STT3A/STT3A-ai-review.yaml	STT3A	P46977	NCBITaxon:9606	Homo sapiens	45	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome-curated (TAS) ER membrane location for STT3A in the CD274 (PD-L1) N-glycosylation reaction. Correct core location.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	35	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome, N-glycan transfer reaction). Consistent with all other ER-membrane annotations.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	36	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome, viral spike protein N-glycosylation pathway). Redundant but correct.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	37	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome). Redundant but correct.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	38	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome). Redundant but correct.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	39	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome). Redundant but correct.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	40	R-HSA-9926534	MITF-M-dependent STT3B gene expression	yes	reactome/R-HSA-9926534.md	MITF-M-dependent STT3B gene expression	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome). Redundant but correct.
human	STT3B	genes/human/STT3B/STT3B-ai-review.yaml	STT3B	Q8TCJ2	NCBITaxon:9606	Homo sapiens	41	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Correct core ER-membrane localization (Reactome, CD274/PD-L1 N-linked glycosylation). Redundant but correct.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	74	R-HSA-2173788	Reactome pathway R-HSA-2173788	no				GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	negative regulation of transforming growth factor beta receptor signaling pathway: a substrate-specific/pleiotropic process attributed to CHIP via degradation of a particular client.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	75	R-HSA-1227986	Reactome pathway R-HSA-1227986	no				GO:0038128	ERBB2 signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ERBB2 signaling pathway: a substrate-specific/pleiotropic process attributed to CHIP via degradation of a particular client.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	76	R-HSA-6807134	Reactome pathway R-HSA-6807134	yes	reactome/R-HSA-6807134.md	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	STUB1/CHIP is a U-box-type E3 ubiquitin-protein ligase; ubiquitin protein ligase activity is a core molecular function.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	77	R-HSA-9009308	Reactome pathway R-HSA-9009308	no				GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	STUB1/CHIP is a U-box-type E3 ubiquitin-protein ligase; ubiquitin protein ligase activity is a core molecular function.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	92	R-HSA-1918092	Reactome pathway R-HSA-1918092	no				GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	STUB1/CHIP is a U-box-type E3 ubiquitin-protein ligase; ubiquitin-protein transferase activity is a core molecular function.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	93	R-HSA-2187368	Reactome pathway R-HSA-2187368	yes	reactome/R-HSA-2187368.md	STUB1 (CHIP) ubiquitinates SMAD3	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	STUB1/CHIP is a U-box-type E3 ubiquitin-protein ligase; ubiquitin-protein transferase activity is a core molecular function.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	156	R-HSA-1918092	Reactome pathway R-HSA-1918092	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	157	R-HSA-2187368	Reactome pathway R-HSA-2187368	yes	reactome/R-HSA-2187368.md	STUB1 (CHIP) ubiquitinates SMAD3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	158	R-HSA-2187375	Reactome pathway R-HSA-2187375	yes	reactome/R-HSA-2187375.md	SMAD3 binds STUB1 (CHIP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	159	R-HSA-6807134	Reactome pathway R-HSA-6807134	yes	reactome/R-HSA-6807134.md	NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	160	R-HSA-9009308	Reactome pathway R-HSA-9009308	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	161	R-HSA-9009309	Reactome pathway R-HSA-9009309	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	162	R-HSA-9688831	Reactome pathway R-HSA-9688831	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	163	R-HSA-9688838	Reactome pathway R-HSA-9688838	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	164	R-HSA-9796368	Reactome pathway R-HSA-9796368	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	STUB1	genes/human/STUB1/STUB1-ai-review.yaml	STUB1	Q9UNE7	NCBITaxon:9606	Homo sapiens	165	R-HSA-9796387	Reactome pathway R-HSA-9796387	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CHIP is predominantly cytoplasmic/cytosolic, where it triages chaperone clients.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	34	R-HSA-158468	SULT1A1 dimer sulfonates PARA to PARA-SO4	yes	reactome/R-HSA-158468.md	SULT1A1 dimer sulfonates PARA to PARA-SO4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the SULT1A1-catalysed sulfonation of paracetamol (acetaminophen) in the cytosol, acting as a homodimer. Correct and more precise than the cytoplasm rows.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	35	R-HSA-158849	Phenol can form a sulfate conjugate	yes	reactome/R-HSA-158849.md	Phenol can form a sulfate conjugate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's generic phenol sulfate-conjugation reaction, explicitly assigned to the cytosol and to the aryl sulfotransferase activity of the SULT1A1 homodimer. Correct.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	36	R-HSA-158860	SULT1A1 dimer sulfonates NHABP	yes	reactome/R-HSA-158860.md	SULT1A1 dimer sulfonates NHABP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's SULT1A1-catalysed sulfonation of the genotoxic metabolite N-hydroxy-4-aminobiphenyl, placed in the hepatic cytosol. Correct; redundant with the other six cytosol rows.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	37	R-HSA-176474	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP	yes	reactome/R-HSA-176474.md	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's 3,3'-diiodothyronine sulfation reaction, placed in the cytosol. Correct; redundant with the other cytosol rows.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	38	R-HSA-176585	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP	yes	reactome/R-HSA-176585.md	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's 3,5,3'-triiodothyronine (T3) sulfation reaction, placed in the cytosol. Correct; redundant with the other cytosol rows.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	39	R-HSA-176646	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP	yes	reactome/R-HSA-176646.md	p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's 4-nitrophenol sulfation reaction, placed in the cytosol. Correct; redundant with the other cytosol rows.
human	SULT1A1	genes/human/SULT1A1/SULT1A1-ai-review.yaml	SULT1A1	P50225	NCBITaxon:9606	Homo sapiens	40	R-HSA-9753277	SULT dimers sulfate APAP to APAP-SO3	yes	reactome/R-HSA-9753277.md	SULT dimers sulfate APAP to APAP-SO3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome's acetaminophen sulfation reaction, catalysed by SULT dimers including SULT1A1 and placed in the cytosol. Correct; redundant with the other cytosol rows.
human	SULT1B1	genes/human/SULT1B1/SULT1B1-ai-review.yaml	SULT1B1	O43704	NCBITaxon:9606	Homo sapiens	29	R-HSA-176474	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP	yes	reactome/R-HSA-176474.md	3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places SULT1B1 in the cytosol as the catalyst of 3,3'-diiodothyronine sulfation.
human	SULT1B1	genes/human/SULT1B1/SULT1B1-ai-review.yaml	SULT1B1	O43704	NCBITaxon:9606	Homo sapiens	30	R-HSA-176585	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP	yes	reactome/R-HSA-176585.md	3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places SULT1B1 in the cytosol as the catalyst of T3 sulfation.
human	SUMF2	genes/human/SUMF2/SUMF2-ai-review.yaml	SUMF2	Q8NBJ7	NCBITaxon:9606	Homo sapiens	10	R-HSA-163841	Cysteine to formylglycine conversion (sulfatase maturation)	yes	reactome/R-HSA-163841.md	Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation	Homo sapiens	GO:0043687	post-translational protein modification	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Post-translational protein modification (TAS): pathway context of sulfatase Cys->formylglycine maturation that SUMF2 modulates.
human	SUMF2	genes/human/SUMF2/SUMF2-ai-review.yaml	SUMF2	Q8NBJ7	NCBITaxon:9606	Homo sapiens	11	R-HSA-9840310	Glycosphingolipid metabolism / catabolism	yes	reactome/R-HSA-9840310.md	Glycosphingolipid catabolism	Homo sapiens	GO:0046479	glycosphingolipid catabolic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Glycosphingolipid catabolic process (TAS): downstream consequence of sulfatase activity, which SUMF2 indirectly modulates by inhibiting SUMF1.
human	SUMF2	genes/human/SUMF2/SUMF2-ai-review.yaml	SUMF2	Q8NBJ7	NCBITaxon:9606	Homo sapiens	12	R-HSA-1614336	Sulfatase activation by SUMF1 (FGE)	no				GO:0004857	enzyme inhibitor activity	TAS	enables	MF	false		ACCEPT	Enzyme inhibitor activity: SUMF2 inhibits the sulfatase-activating (formylglycine-generating) activity of SUMF1 via heterodimerization. This is SUMF2's defining molecular role. Falcon deep research reinforces that SUMF2/pFGE is catalytically inactive yet binds sulfatase peptides and acts as a negative regulator of sulfatase activation, and that co-expression of pFGE compromises FGE's ability to generate active sulfatases.
human	SUMF2	genes/human/SUMF2/SUMF2-ai-review.yaml	SUMF2	Q8NBJ7	NCBITaxon:9606	Homo sapiens	15	R-HSA-1614336	Sulfatase activation by SUMF1 (FGE)	no				GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	ER lumen localization (TAS).
human	SUOX	genes/human/SUOX/SUOX-ai-review.yaml	SUOX	P51687	NCBITaxon:9606	Homo sapiens	21	R-HSA-1614544	Sulfite is oxidized to sulfate	yes	reactome/R-HSA-1614544.md	Sulfite is oxidized to sulfate	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Conflicts with the authoritative UniProt localization. SUOX resides in the mitochondrial intermembrane space (GO:0005758), not the matrix; the Reactome placement is an over-annotation of location.
human	SURF1	genes/human/SURF1/SURF1-ai-review.yaml	SURF1	Q15526	NCBITaxon:9606	Homo sapiens	10	R-HSA-9865350	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	yes	reactome/R-HSA-9865350.md	Nascent MT-CO1 binds to MITRAC, Mg2+, PE, CL	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome places SURF1 at the mitochondrial inner membrane as part of the MITRAC complex in the step where nascent MT-CO1 binds to MITRAC. SURF1 is listed as a subunit of MITRAC alongside CMC1, COX14, COA1, COA3, and SMIM20 (MITRAC7).
human	SURF1	genes/human/SURF1/SURF1-ai-review.yaml	SURF1	Q15526	NCBITaxon:9606	Homo sapiens	11	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This Reactome annotation places SURF1 at the inner membrane during the step where TIMM21 carries COX4, COX5A, and COX6C subunits to the MT-CO1:MITRAC complex. SURF1 is part of the MITRAC complex that receives these imported subunits.
human	SURF1	genes/human/SURF1/SURF1-ai-review.yaml	SURF1	Q15526	NCBITaxon:9606	Homo sapiens	12	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This Reactome annotation places SURF1 at the inner membrane during the copper insertion step into MT-CO1. The Reactome entry for this step describes a metallochaperone complex that inserts Cu2+ into MT-CO1, and SURF1 is present in the broader assembly context at this stage.
human	SURF1	genes/human/SURF1/SURF1-ai-review.yaml	SURF1	Q15526	NCBITaxon:9606	Homo sapiens	13	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"This Reactome annotation places SURF1 at the inner membrane during the step where MT-CO1 and MT-CO2 complexes associate and heme moieties are installed. Reactome specifically notes that ""the SURF1 subunit of MITRAC may act as an additional chaperone, for which there is evidence in bacterial models."" This is a key step where SURF1 may directly facilitate heme a insertion."
human	SURF1	genes/human/SURF1/SURF1-ai-review.yaml	SURF1	Q15526	NCBITaxon:9606	Homo sapiens	14	R-HSA-9865663	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	yes	reactome/R-HSA-9865663.md	MT-CO3, COX6A,B,7A and NDUFA4 bind to holo-MT-CO1,2 complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	This Reactome annotation places SURF1 at the inner membrane during the final Complex IV assembly step where MT-CO3, COX6A/B, COX7A, and NDUFA4 bind to the holo-MT-CO1,2 complex. SURF1 is not specifically mentioned in this final step description, suggesting it may no longer be part of the complex at this late stage.
human	SYNGAP1	genes/human/SYNGAP1/SYNGAP1-ai-review.yaml	SYNGAP1	Q96PV0	NCBITaxon:9606	Homo sapiens	27	R-HSA-5658231	RAS GAPs stimulate RAS GTPase activity	yes	reactome/R-HSA-5658231.md	RAS GAPs stimulate RAS GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	SynGAP is a cytosolic protein that participates in RAS GAP-mediated stimulation of RAS GTPase activity.
human	SYNGAP1	genes/human/SYNGAP1/SYNGAP1-ai-review.yaml	SYNGAP1	Q96PV0	NCBITaxon:9606	Homo sapiens	28	R-HSA-5658435	RAS GAPs bind RAS:GTP	yes	reactome/R-HSA-5658435.md	RAS GAPs bind RAS:GTP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate cytosol annotation from Reactome pathway describing RAS GAP binding to RAS:GTP.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	28	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	TAS from Reactome pathway for ubiquitination of unfolded glycoproteins by the OS9:SEL1:ERAD E3 ligase:DERL2 complex. Consistent with core function.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	42	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	TAS from Reactome for ER mannose trimming. SYVN1/HRD1 is involved in the ERQC pathway where mannose-trimmed glycoproteins are delivered to the HRD1 complex for ERAD (PMID:21062743). However, SYVN1 does not directly perform mannose trimming; it is a downstream recipient of mannose-trimmed substrates.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	88	R-HSA-1791084	Expression of SYVN1 (HRD1)	yes	reactome/R-HSA-1791084.md	Expression of SYVN1 (HRD1)	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for expression of SYVN1 at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	89	R-HSA-5362412	SYVN1 ubiquitinates Hh C-terminal fragments	yes	reactome/R-HSA-5362412.md	SYVN1 ubiquitinates Hh C-terminal fragments	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for SYVN1 ubiquitination of Hedgehog C-terminal fragments at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	90	R-HSA-5362441	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	yes	reactome/R-HSA-5362441.md	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for recruitment of Hedgehog fragments to SEL1:SYVN1 at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	91	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	yes	reactome/R-HSA-5362459.md	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for VCP-catalyzed translocation of Hedgehog-C at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	92	R-HSA-5387386	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	yes	reactome/R-HSA-5387386.md	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for recruitment of Hedgehog processing variants to SEL1:SYVN at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	93	R-HSA-5387389	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	yes	reactome/R-HSA-5387389.md	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for VCP-dependent translocation of Hedgehog processing variants at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	94	R-HSA-5483238	Hh processing variants are ubiquitinated	yes	reactome/R-HSA-5483238.md	Hh processing variants are ubiquitinated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for ubiquitination of Hedgehog processing variants at the ER membrane.
human	SYVN1	genes/human/SYVN1/SYVN1-ai-review.yaml	SYVN1	Q86TM6	NCBITaxon:9606	Homo sapiens	95	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitination of unfolded glycoproteins at the ER membrane.
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	25	R-HSA-5659989	Defective TALDO1 does not transform SH7P, GA3P to Fru(6)P, E4P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing transaldolase in the cytosol (transaldolase-deficiency reaction module).
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	26	R-HSA-5659998	Defective TALDO1 does not transform Fru(6)P, E4P to SH7P, GA3P	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing transaldolase in the cytosol (transaldolase-deficiency reaction module).
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	30	R-HSA-163764	D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing transaldolase in the cytosol.
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	31	R-HSA-71334	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate	yes	reactome/R-HSA-71334.md	sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing transaldolase in the cytosol (pentose phosphate pathway module).
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	32	R-HSA-8950367	Expression of transaldolase 1	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing transaldolase in the cytosol.
human	TALDO1	genes/human/TALDO1/TALDO1-ai-review.yaml	TALDO1	P37837	NCBITaxon:9606	Homo sapiens	33	R-HSA-9761858	NFE2L2-dependent TALDO1 gene expression	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS placing transaldolase in the cytosol.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	44	R-HSA-166245	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	yes	reactome/R-HSA-166245.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	45	R-HSA-166271	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	yes	reactome/R-HSA-166271.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	46	R-HSA-5362500	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-5362500.md	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	47	R-HSA-9013978	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	yes	reactome/R-HSA-9013978.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	48	R-HSA-9013979	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	yes	reactome/R-HSA-9013979.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	49	R-HSA-9013990	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA	yes	reactome/R-HSA-9013990.md	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	50	R-HSA-9823904	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823904.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	51	R-HSA-9823906	TBK1 is phosphorylated within the activated TLR4 complex	yes	reactome/R-HSA-9823906.md	TBK1 is phosphorylated within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	52	R-HSA-9823910	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823910.md	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	53	R-HSA-9823932	Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823932.md	Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	54	R-HSA-9823934	OPTN binds TBK1 within the activated TLR4 complex	yes	reactome/R-HSA-9823934.md	OPTN binds TBK1 within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	55	R-HSA-9823939	IKKε (IKBKE) is ubiquitinated within the activated TLR4	yes	reactome/R-HSA-9823939.md	IKKε (IKBKE) is ubiquitinated within the activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	56	R-HSA-9824882	IKKε (IKBKE) is phosphorylated within the activated TLR4 complex	yes	reactome/R-HSA-9824882.md	IKKε (IKBKE) is phosphorylated within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	57	R-HSA-9828196	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828196.md	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	58	R-HSA-9828200	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828200.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	59	R-HSA-9828204	IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828204.md	IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	60	R-HSA-9828205	TBK1 is phosphorylated within the activated TLR3 complex	yes	reactome/R-HSA-9828205.md	TBK1 is phosphorylated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	61	R-HSA-9828209	OPTN binds TBK1 within the activated TLR3 complex	yes	reactome/R-HSA-9828209.md	OPTN binds TBK1 within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	62	R-HSA-9830706	IKKε (IKBKE) is phosphorylated within the activated TLR3 complex	yes	reactome/R-HSA-9830706.md	IKKε (IKBKE) is phosphorylated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	63	R-HSA-9830710	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex	yes	reactome/R-HSA-9830710.md	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	66	R-HSA-5362486	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4	yes	reactome/R-HSA-5362486.md	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	67	R-HSA-9013985	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3	yes	reactome/R-HSA-9013985.md	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	68	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	69	R-HSA-933527	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	yes	reactome/R-HSA-933527.md	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	70	R-HSA-933537	Recruitment of TANK to TRAF6	yes	reactome/R-HSA-933537.md	Recruitment of TANK to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	71	R-HSA-933538	Recruitment of IRF7 to TRAF6	yes	reactome/R-HSA-933538.md	Recruitment of IRF7 to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	72	R-HSA-9705145	TBK1, IKBKE form homodimers	yes	reactome/R-HSA-9705145.md	TBK1, IKBKE form homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TANK	genes/human/TANK/TANK-ai-review.yaml	TANK	Q92844	NCBITaxon:9606	Homo sapiens	73	R-HSA-9705323	Phosphorylation of TBK1/IKBKE	yes	reactome/R-HSA-9705323.md	Phosphorylation of TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway-step curation placing TANK in the cytosol within TLR/TBK1-IKKepsilon-IRF3/7 activation reactions. Correct compartment, consistent with TANK's cytoplasmic adaptor role.
human	TAS2R16	genes/human/TAS2R16/TAS2R16-ai-review.yaml	TAS2R16	Q9NYV7	NCBITaxon:9606	Homo sapiens	11	R-HSA-3296233	T2Rs bind bitter-tasting compounds	yes	reactome/R-HSA-3296233.md	T2Rs bind bitter-tasting compounds	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway step ""T2Rs bind bitter-tasting compounds"" places TAS2R16 at the plasma membrane as part of the generic bitter-taste-receptor pathway reaction."
human	TAS2R16	genes/human/TAS2R16/TAS2R16-ai-review.yaml	TAS2R16	Q9NYV7	NCBITaxon:9606	Homo sapiens	12	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway step ""Liganded Gi-activating GPCR acts as a GEF for Gi"" - generic GPCR/Gi-signaling reaction placing the receptor at the plasma membrane."
human	TAS2R16	genes/human/TAS2R16/TAS2R16-ai-review.yaml	TAS2R16	Q9NYV7	NCBITaxon:9606	Homo sapiens	13	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway step ""The Ligand:GPCR:Gi complex dissociates"" - part of the same generic Gi-GPCR reaction cycle."
human	TAS2R16	genes/human/TAS2R16/TAS2R16-ai-review.yaml	TAS2R16	Q9NYV7	NCBITaxon:9606	Homo sapiens	14	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway step ""Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi"" - part of the same generic Gi-GPCR reaction cycle."
human	TAS2R16	genes/human/TAS2R16/TAS2R16-ai-review.yaml	TAS2R16	Q9NYV7	NCBITaxon:9606	Homo sapiens	15	R-HSA-9728748	Bitter compound binds bitter taste receptor (TAS2R)	yes	reactome/R-HSA-9728748.md	Bitter compound binds bitter taste receptor (TAS2R)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"Reactome pathway step ""Bitter compound binds bitter taste receptor (TAS2R)"" - the TAS2R-family-specific ligand-binding reaction, placing TAS2R16 at the plasma membrane."
human	TAS2R38	genes/human/TAS2R38/TAS2R38-ai-review.yaml	TAS2R38	P59533	NCBITaxon:9606	Homo sapiens	7	R-HSA-3296233	T2Rs bind bitter-tasting compounds	yes	reactome/R-HSA-3296233.md	T2Rs bind bitter-tasting compounds	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the receptor at the plasma membrane in the ligand-binding step of the T2R/Gi signaling reaction.
human	TAS2R38	genes/human/TAS2R38/TAS2R38-ai-review.yaml	TAS2R38	P59533	NCBITaxon:9606	Homo sapiens	8	R-HSA-380073	Liganded Gi-activating GPCR acts as a GEF for Gi	yes	reactome/R-HSA-380073.md	Liganded Gi-activating GPCR acts as a GEF for Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing the receptor at the plasma membrane during Gi-GEF activity.
human	TAS2R38	genes/human/TAS2R38/TAS2R38-ai-review.yaml	TAS2R38	P59533	NCBITaxon:9606	Homo sapiens	9	R-HSA-749454	The Ligand:GPCR:Gi complex dissociates	yes	reactome/R-HSA-749454.md	The Ligand:GPCR:Gi complex dissociates	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement for the Ligand:GPCR:Gi complex dissociation step.
human	TAS2R38	genes/human/TAS2R38/TAS2R38-ai-review.yaml	TAS2R38	P59533	NCBITaxon:9606	Homo sapiens	10	R-HSA-749456	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	yes	reactome/R-HSA-749456.md	Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement for ligand-bound Gi-activating GPCRs binding inactive heterotrimeric Gi.
human	TAS2R38	genes/human/TAS2R38/TAS2R38-ai-review.yaml	TAS2R38	P59533	NCBITaxon:9606	Homo sapiens	11	R-HSA-9728748	Bitter compound binds bitter taste receptor (TAS2R)	yes	reactome/R-HSA-9728748.md	Bitter compound binds bitter taste receptor (TAS2R)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement for the bitter-compound-binding step specific to TAS2R receptors.
human	TAT	genes/human/TAT/TAT-ai-review.yaml	TAT	P17735	NCBITaxon:9606	Homo sapiens	35	R-HSA-517444	TAT aminates HPP	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome traceable-author-statement placing TAT in the cytosol, in the context of the reaction ""TAT aminates HPP"". Correct subcellular location."
human	TAT	genes/human/TAT/TAT-ai-review.yaml	TAT	P17735	NCBITaxon:9606	Homo sapiens	36	R-HSA-71155	TAT deaminates tyrosine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome TAS placing TAT in the cytosol in the context of the reaction ""TAT deaminates tyrosine"" (the forward tyrosine transamination step)."
human	TAX1BP1	genes/human/TAX1BP1/TAX1BP1-ai-review.yaml	TAX1BP1	Q86VP1	NCBITaxon:9606	Homo sapiens	48	R-HSA-5693055	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	yes	reactome/R-HSA-5693055.md	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation placing the TAX1BP1:A20 complex in the cytosol, where it binds RIPK1-containing complexes during NF-kappaB regulation. Cytosol is the correct major compartment for TAX1BP1.
human	TAX1BP1	genes/human/TAX1BP1/TAX1BP1-ai-review.yaml	TAX1BP1	Q86VP1	NCBITaxon:9606	Homo sapiens	49	R-HSA-5693108	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	yes	reactome/R-HSA-5693108.md	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization, associated with the A20-mediated K48 ubiquitination of RIPK1 event in which the TAX1BP1:A20 complex participates. Cytosol is the correct major compartment.
human	TAX1BP1	genes/human/TAX1BP1/TAX1BP1-ai-review.yaml	TAX1BP1	Q86VP1	NCBITaxon:9606	Homo sapiens	50	R-HSA-937337	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	yes	reactome/R-HSA-937337.md	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for cytosol localization, associated with the TAX1BP1:A20 inhibition of TBK1/IKKi K63-polyubiquitination event. Cytosol is the correct major compartment for TAX1BP1.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	70	R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	yes	reactome/R-HSA-5205685.md	PINK1-PRKN Mediated Mitophagy	Homo sapiens	GO:0016236	macroautophagy	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Macroautophagy (Reactome PINK1-PRKN mitophagy TAS). A generic parent of TBK1's specific positive-regulatory autophagy role.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	71	R-HSA-1834941	STING mediated induction of host immune responses	yes	reactome/R-HSA-1834941.md	STING mediated induction of host immune responses	Homo sapiens	GO:0032481	positive regulation of type I interferon production	TAS	involved_in	BP	false		ACCEPT	Positive regulation of type I interferon production: core process by which TBK1 phosphorylates IRF3/IRF7 to induce IFN-alpha/IFN-beta.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	72	R-HSA-3270619	IRF3-mediated induction of type I IFN	yes	reactome/R-HSA-3270619.md	IRF3-mediated induction of type I IFN	Homo sapiens	GO:0032481	positive regulation of type I interferon production	TAS	involved_in	BP	false		ACCEPT	Positive regulation of type I interferon production: core process by which TBK1 phosphorylates IRF3/IRF7 to induce IFN-alpha/IFN-beta.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	74	R-HSA-2396007	IRF3 is phosphorylated by TBK1	yes	reactome/R-HSA-2396007.md	IRF3 is phosphorylated by TBK1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	TBK1 is a non-canonical IKK-related serine/threonine protein kinase; this is its core, extensively documented molecular function (trans-autophosphorylation at Ser172; phosphorylation of IRF3/IRF7, the adaptors MAVS/STING1/TICAM1, OPTN, SMCR8, ATG8s, etc.).
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	75	R-HSA-3249371	TBK1 phosphorylates STAT6 at Ser407	yes	reactome/R-HSA-3249371.md	TBK1 phosphorylates STAT6 at Ser407	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	TBK1 is a non-canonical IKK-related serine/threonine protein kinase; this is its core, extensively documented molecular function (trans-autophosphorylation at Ser172; phosphorylation of IRF3/IRF7, the adaptors MAVS/STING1/TICAM1, OPTN, SMCR8, ATG8s, etc.).
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	76	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	TBK1 is a non-canonical IKK-related serine/threonine protein kinase; this is its core, extensively documented molecular function (trans-autophosphorylation at Ser172; phosphorylation of IRF3/IRF7, the adaptors MAVS/STING1/TICAM1, OPTN, SMCR8, ATG8s, etc.).
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	132	R-HSA-9823904	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823904.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	133	R-HSA-9828200	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828200.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	145	R-HSA-9008684	TBK1 phosphorylation	yes	reactome/R-HSA-9008684.md	TBK1 phosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	154	R-HSA-3249386	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1	yes	reactome/R-HSA-3249386.md	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	155	R-HSA-8948709	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3	yes	reactome/R-HSA-8948709.md	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	156	R-HSA-1606327	Phosphorylation and release of IRF3	yes	reactome/R-HSA-1606327.md	Phosphorylation and release of IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	157	R-HSA-166245	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	yes	reactome/R-HSA-166245.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	158	R-HSA-166271	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	yes	reactome/R-HSA-166271.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	159	R-HSA-2396002	TBK1 is phosphorylated within STING:TBK1:IRF3 complex	yes	reactome/R-HSA-2396002.md	TBK1 is phosphorylated within STING:TBK1:IRF3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	160	R-HSA-2396007	IRF3 is phosphorylated by TBK1	yes	reactome/R-HSA-2396007.md	IRF3 is phosphorylated by TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	161	R-HSA-3249371	TBK1 phosphorylates STAT6 at Ser407	yes	reactome/R-HSA-3249371.md	TBK1 phosphorylates STAT6 at Ser407	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	162	R-HSA-3249390	TBK1 is phosphorylated within STING:TBK1:STAT6 complex	yes	reactome/R-HSA-3249390.md	TBK1 is phosphorylated within STING:TBK1:STAT6 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	163	R-HSA-3249392	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3	yes	reactome/R-HSA-3249392.md	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	164	R-HSA-8948703	NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1	yes	reactome/R-HSA-8948703.md	NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	165	R-HSA-9013978	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	yes	reactome/R-HSA-9013978.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	166	R-HSA-9013979	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	yes	reactome/R-HSA-9013979.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	167	R-HSA-918229	Phosphorylation and release of IRF3/IRF7	yes	reactome/R-HSA-918229.md	Phosphorylation and release of IRF3/IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	168	R-HSA-918232	Recruitment of IRF3,IRF7	yes	reactome/R-HSA-918232.md	Recruitment of IRF3,IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	169	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	170	R-HSA-933538	Recruitment of IRF7 to TRAF6	yes	reactome/R-HSA-933538.md	Recruitment of IRF7 to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	171	R-HSA-9679819	TBK1 binds amlexanox	yes	reactome/R-HSA-9679819.md	TBK1 binds amlexanox	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	172	R-HSA-9705320	TBK1, IKBKE are autophosphorylated at Ser172	yes	reactome/R-HSA-9705320.md	TBK1, IKBKE are autophosphorylated at Ser172	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	173	R-HSA-9705323	Phosphorylation of TBK1/IKBKE	yes	reactome/R-HSA-9705323.md	Phosphorylation of TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	174	R-HSA-9817397	TBK1, IKBKE phosphorylate RIPK1 at T189	yes	reactome/R-HSA-9817397.md	TBK1, IKBKE phosphorylate RIPK1 at T189	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	175	R-HSA-9817411	TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex	yes	reactome/R-HSA-9817411.md	TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	176	R-HSA-9823906	TBK1 is phosphorylated within the activated TLR4 complex	yes	reactome/R-HSA-9823906.md	TBK1 is phosphorylated within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	177	R-HSA-9824892	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	yes	reactome/R-HSA-9824892.md	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	178	R-HSA-9824894	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	yes	reactome/R-HSA-9824894.md	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	179	R-HSA-9824897	p-S-TBK1 phosphorylates OPTN	yes	reactome/R-HSA-9824897.md	p-S-TBK1 phosphorylates OPTN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	180	R-HSA-9828205	TBK1 is phosphorylated within the activated TLR3 complex	yes	reactome/R-HSA-9828205.md	TBK1 is phosphorylated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	181	R-HSA-9840807	OPTN binds ATG9A	yes	reactome/R-HSA-9840807.md	OPTN binds ATG9A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	197	R-HSA-1834939	STING recruits TBK1 and IRF3	yes	reactome/R-HSA-1834939.md	STING recruits TBK1 and IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	198	R-HSA-3249378	STING recruits TBK1 and STAT6	yes	reactome/R-HSA-3249378.md	STING recruits TBK1 and STAT6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	199	R-HSA-918225	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	yes	reactome/R-HSA-918225.md	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	200	R-HSA-933527	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	yes	reactome/R-HSA-933527.md	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	201	R-HSA-937337	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	yes	reactome/R-HSA-937337.md	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	202	R-HSA-9705010	SARS-CoV-2 nsp6 binds TBK1	yes	reactome/R-HSA-9705010.md	SARS-CoV-2 nsp6 binds TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	203	R-HSA-9705082	SARS-CoV-2 nsp13 binds TBK1	yes	reactome/R-HSA-9705082.md	SARS-CoV-2 nsp13 binds TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	204	R-HSA-9705137	TBK1 or IKBKE forms homodimers	yes	reactome/R-HSA-9705137.md	TBK1 or IKBKE forms homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	205	R-HSA-9705145	TBK1, IKBKE form homodimers	yes	reactome/R-HSA-9705145.md	TBK1, IKBKE form homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	206	R-HSA-9709831	HSP90 binds TBK1 and IRF3	yes	reactome/R-HSA-9709831.md	HSP90 binds TBK1 and IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	207	R-HSA-9709852	MAVS:TOMM70 recruits HSP90:TBK1:IRF3	yes	reactome/R-HSA-9709852.md	MAVS:TOMM70 recruits HSP90:TBK1:IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	208	R-HSA-9710988	SARS-CoV-1 M protein interacts with TBK1/IKBKE	yes	reactome/R-HSA-9710988.md	SARS-CoV-1 M protein interacts with TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	209	R-HSA-9754827	SARS-CoV-2 M binds TBK1	yes	reactome/R-HSA-9754827.md	SARS-CoV-2 M binds TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	210	R-HSA-9823910	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823910.md	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	211	R-HSA-9823934	OPTN binds TBK1 within the activated TLR4 complex	yes	reactome/R-HSA-9823934.md	OPTN binds TBK1 within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	212	R-HSA-9824888	OPTN, TBK1 bind ubiquitinated MOM proteins	yes	reactome/R-HSA-9824888.md	OPTN, TBK1 bind ubiquitinated MOM proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	213	R-HSA-9828196	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828196.md	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TBK1	genes/human/TBK1/TBK1-ai-review.yaml	TBK1	Q9UHD2	NCBITaxon:9606	Homo sapiens	214	R-HSA-9828209	OPTN binds TBK1 within the activated TLR3 complex	yes	reactome/R-HSA-9828209.md	OPTN binds TBK1 within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction-step annotation. Correct core compartment, though one of many redundant per-step pathway localizations.
human	TCF25	genes/human/TCF25/TCF25-ai-review.yaml	TCF25	Q9BQ70	NCBITaxon:9606	Homo sapiens	16	R-HSA-9948318	Reactome: TCF25 cytosol localization	yes	reactome/R-HSA-9948318.md	LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of TCF25 cytosolic localization, consistent with its RQC role.
human	TCF25	genes/human/TCF25/TCF25-ai-review.yaml	TCF25	Q9BQ70	NCBITaxon:9606	Homo sapiens	17	R-HSA-9948362	Reactome: TCF25 cytosol localization	yes	reactome/R-HSA-9948362.md	LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of TCF25 cytosolic localization.
human	TCF25	genes/human/TCF25/TCF25-ai-review.yaml	TCF25	Q9BQ70	NCBITaxon:9606	Homo sapiens	18	R-HSA-9948427	Reactome: TCF25 cytosol localization	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of TCF25 cytosolic localization.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	8	R-HSA-9758881	Uptake of dietary cobalamins into enterocytes	yes	reactome/R-HSA-9758881.md	Uptake of dietary cobalamins into enterocytes	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS annotation placing TCN1 in ""Uptake of dietary cobalamins into enterocytes"". Haptocorrin binds dietary RCbl in saliva/stomach, protecting it, so participation in the cobalamin transport process is correct."
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	9	R-HSA-9758890	Transport of RCbl within the body	yes	reactome/R-HSA-9758890.md	Transport of RCbl within the body	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	"Reactome TAS annotation placing TCN1 in ""Transport of RCbl within the body"". Haptocorrin carries the majority of circulating plasma cobalamin and scavenges corrinoids for hepatobiliary clearance, so involvement in body-wide cobalamin transport is correct."
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	13	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation to specific (secondary) granule lumen. TCN1 is a major constituent of neutrophil secondary/specific granules and is released by neutrophil degranulation, so this localization is correct.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	14	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:1904724	tertiary granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome TAS annotation to tertiary granule lumen, from the neutrophil degranulation pathway. TCN1 is primarily a specific/secondary granule protein; Reactome models it among granule-lumen proteins exocytosed during degranulation. Retained as a non-core localization since the primary granule assignment is the specific granule.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	16	R-HSA-3132753	Pancreatic proteases degrade TCN1:RCbl	yes	reactome/R-HSA-3132753.md	Pancreatic proteases degrade TCN1:RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Pancreatic proteases degrade TCN1:RCbl) placing TCN1 in the extracellular region, where the haptocorrin:cobalamin complex is degraded by pancreatic proteases in the small intestine. Correct localization.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	17	R-HSA-3132759	TCN1 binds RCbl	yes	reactome/R-HSA-3132759.md	TCN1 binds RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (TCN1 binds RCbl) placing TCN1 in the extracellular region, where secreted haptocorrin binds free/protein-released RCbl in saliva and stomach. Correct localization.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	18	R-HSA-3245898	TCN1 binds correnoids in the circulation	yes	reactome/R-HSA-3245898.md	TCN1 binds correnoids in the circulation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (TCN1 binds corrinoids in the circulation) placing TCN1 in the extracellular region (plasma), where haptocorrin binds inactive corrinoid analogues for hepatobiliary clearance. Correct localization.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798745	Exocytosis of tertiary granule lumen proteins	yes	reactome/R-HSA-6798745.md	Exocytosis of tertiary granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Exocytosis of tertiary granule lumen proteins) placing released TCN1 in the extracellular region following neutrophil degranulation. Consistent with the secreted/extracellular localization.
human	TCN1	genes/human/TCN1/TCN1-ai-review.yaml	TCN1	P20061	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation (Exocytosis of specific granule lumen proteins) placing released TCN1 in the extracellular region following neutrophil degranulation. Consistent with the secreted/extracellular localization.
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	8	R-HSA-9758890	Transport of RCbl within the body	yes	reactome/R-HSA-9758890.md	Transport of RCbl within the body	Homo sapiens	GO:0015889	cobalamin transport	TAS	involved_in	BP	false		ACCEPT	"Reactome (TAS) annotation of cobalamin transport, from the pathway ""Transport of RCbl within the body"", capturing transcobalamin-2's role in moving cobalamin from the enterocyte to peripheral cells."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	11	R-HSA-3000074	TCN2 binds RCbl in the circulation	yes	reactome/R-HSA-3000074.md	TCN2 binds RCbl in the circulation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the reaction ""TCN2 binds RCbl in the circulation"", where secreted transcobalamin-2 binds cobalamin in plasma."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	12	R-HSA-3000122	CD320 binds extracellular TCN2:RCbl	yes	reactome/R-HSA-3000122.md	CD320 binds extracellular TCN2:RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the reaction ""CD320 binds extracellular TCN2:RCbl""."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	13	R-HSA-3325546	Defective CD320 does not transport extracellular TCII:Cbl to endosome	yes	reactome/R-HSA-3325546.md	Defective CD320 does not transport extracellular TCII:Cbl to endosome	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the disease reaction ""Defective CD320 does not transport extracellular TCII:Cbl to endosome""."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	14	R-HSA-9759202	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-9759202.md	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the reaction ""LRP2-mediated TCN2:RCbl uptake and delivery to lysosome"" (an alternative megalin/LRP2 uptake route, e.g. in renal tubule)."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	15	R-HSA-9759209	LRP2 binds extracellular TCN2:RCbl	yes	reactome/R-HSA-9759209.md	LRP2 binds extracellular TCN2:RCbl	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the reaction ""LRP2 binds extracellular TCN2:RCbl""."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	16	R-HSA-3000112	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000112.md	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation of plasma membrane, from ""CD320-mediated TCN2:RCbl uptake and delivery to lysosome"", reflecting the transcobalamin-2:cobalamin complex being bound at the cell surface by CD320 before endocytosis."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	17	R-HSA-3000122	CD320 binds extracellular TCN2:RCbl	yes	reactome/R-HSA-3000122.md	CD320 binds extracellular TCN2:RCbl	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation of plasma membrane, from ""CD320 binds extracellular TCN2:RCbl"", reflecting the transcobalamin-2:cobalamin complex engaging its cell-surface receptor."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	18	R-HSA-3000112	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-3000112.md	CD320-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation of lysosomal lumen, from ""CD320-mediated TCN2:RCbl uptake and delivery to lysosome"", where the internalized transcobalamin-2:cobalamin complex is delivered to the lysosome."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	19	R-HSA-3000263	TCN2:RCbl is degraded to release RCbl	yes	reactome/R-HSA-3000263.md	TCN2:RCbl is degraded to release RCbl	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation of lysosomal lumen, from ""TCN2:RCbl is degraded to release RCbl"", where a lysosomal protease degrades transcobalamin-2 to liberate cobalamin."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	20	R-HSA-9759202	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	yes	reactome/R-HSA-9759202.md	LRP2-mediated TCN2:RCbl uptake and delivery to lysosome	Homo sapiens	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"Reactome (TAS) annotation of lysosomal lumen, from ""LRP2-mediated TCN2:RCbl uptake and delivery to lysosome"" (LRP2/megalin uptake route)."
human	TCN2	genes/human/TCN2/TCN2-ai-review.yaml	TCN2	P20062	NCBITaxon:9606	Homo sapiens	25	R-HSA-3299657	Defective TCII does not bind Cbl in the circulation	yes	reactome/R-HSA-3299657.md	Defective TCII does not bind Cbl in the circulation	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) annotation of extracellular region, from the disease reaction ""Defective TCII does not bind Cbl in the circulation""."
human	TDO2	genes/human/TDO2/TDO2-ai-review.yaml	TDO2	P48775	NCBITaxon:9606	Homo sapiens	35	R-HSA-71188	TDO tetramer dioxygenates L-Trp to NFK	yes	reactome/R-HSA-71188.md	TDO tetramer dioxygenates L-Trp to NFK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Author-asserted cytosolic localization (Reactome). Consistent with IDA evidence and accepted as core cellular component.
human	TECR	genes/human/TECR/TECR-ai-review.yaml	TECR	Q9NZ01	NCBITaxon:9606	Homo sapiens	14	R-HSA-75876	Synthesis of very long-chain fatty acyl-CoAs	yes	reactome/R-HSA-75876.md	Synthesis of very long-chain fatty acyl-CoAs	Homo sapiens	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome pathway assignment (Synthesis of very long-chain fatty acyl-CoAs) to long-chain fatty-acyl-CoA biosynthesis. Accurate description of the elongation product TECR helps generate; consistent with the fatty acid elongation / VLCFA biosynthesis core processes. Keep as non-core (the more specific VLCFA biosynthetic process is the primary process term).
human	TECR	genes/human/TECR/TECR-ai-review.yaml	TECR	Q9NZ01	NCBITaxon:9606	Homo sapiens	17	R-HSA-548831	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA	yes	reactome/R-HSA-548831.md	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA	Homo sapiens	GO:0017099	very-long-chain fatty acyl-CoA dehydrogenase activity	TAS	enables	MF	false		MODIFY	"Reactome models the TECR-catalyzed reaction (trans-octadec-2-enoyl-CoA + NADPH -> stearoyl-CoA + NADP) in the reverse ""dehydrogenate"" direction and maps it to a dehydrogenase molecular function. Physiologically TECR is a reductase (NADPH-consuming), catalyzing the fourth reductive step of elongation; the dehydrogenase MF misrepresents the enzyme's biological direction. Modify to the correct reductase MF (GO:0102758). Not removed (TAS; same catalytic activity written in the reverse direction)."
human	TECR	genes/human/TECR/TECR-ai-review.yaml	TECR	Q9NZ01	NCBITaxon:9606	Homo sapiens	26	R-HSA-548831	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA	yes	reactome/R-HSA-548831.md	TECR,TECRL dehydrogenate TOD-CoA to ST-CoA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the ER membrane, consistent with the experimental evidence. Core location (redundant with the IDA/EXP ER membrane annotations).
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	18	R-HSA-163090	Elongation Of The Telomeric Chromosome End	yes	reactome/R-HSA-163090.md	Elongation Of The Telomeric Chromosome End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for telomere elongation.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	146	R-HSA-163096	Recruitment of Telomerase RNP to the Telomeric Chromosome End	yes	reactome/R-HSA-163096.md	Recruitment of Telomerase RNP to the Telomeric Chromosome End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for telomerase RNP recruitment to telomeres.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	147	R-HSA-163099	Alignment Of The RNA Template On The Telomeric Chromosome End	yes	reactome/R-HSA-163099.md	Alignment Of The RNA Template On The Telomeric Chromosome End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for RNA template alignment.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	148	R-HSA-163120	Disassociation of Telomerase RNP and the Chromosome End	yes	reactome/R-HSA-163120.md	Disassociation of Telomerase RNP and the Chromosome End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for telomerase RNP disassociation.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	149	R-HSA-164616	Biogenesis and assembly of the telomerase RNP	yes	reactome/R-HSA-164616.md	Biogenesis and assembly of the telomerase RNP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for telomerase biogenesis.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	150	R-HSA-164617	Elongation of Extended Telomeric Chromosome End	yes	reactome/R-HSA-164617.md	Elongation of Extended Telomeric Chromosome End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for telomere elongation.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	151	R-HSA-164620	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End	yes	reactome/R-HSA-164620.md	Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for template translocation.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	152	R-HSA-3322422	Beta-catenin recruits SMARCA4	yes	reactome/R-HSA-3322422.md	Beta-catenin recruits SMARCA4	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for beta-catenin/SMARCA4 interaction.
human	TERT	genes/human/TERT/TERT-ai-review.yaml	TERT	O14746	NCBITaxon:9606	Homo sapiens	153	R-HSA-9858734	MITF-M-dependent TERT expression	yes	reactome/R-HSA-9858734.md	MITF-M-dependent TERT expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization for MITF-mediated TERT expression.
human	TFR2	genes/human/TFR2/TFR2-ai-review.yaml	TFR2	Q9UP52	NCBITaxon:9606	Homo sapiens	18	R-HSA-5691150	TFR2 dimer binds 2xholoTF	yes	reactome/R-HSA-5691150.md	TFR2 dimer binds 2xholoTF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TFR2-alpha is a single-pass cell-surface receptor that operates at the plasma membrane.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	70	R-HSA-5691154	HFE binds TFRC dimer	yes	reactome/R-HSA-5691154.md	HFE binds TFRC dimer	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	71	R-HSA-8866277	AP-2 directly binds some endocytic cargo	yes	reactome/R-HSA-8866277.md	AP-2 directly binds some endocytic cargo	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	72	R-HSA-8867754	F- and N- BAR domain proteins bind the clathrin-coated pit	yes	reactome/R-HSA-8867754.md	F- and N- BAR domain proteins bind the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	73	R-HSA-8867756	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	yes	reactome/R-HSA-8867756.md	CLASP proteins and cargo are recruited to the nascent clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	74	R-HSA-8868071	Clathrin recruits PIK3C2A	yes	reactome/R-HSA-8868071.md	Clathrin recruits PIK3C2A	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	75	R-HSA-8868072	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	yes	reactome/R-HSA-8868072.md	Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	76	R-HSA-8868230	SNX9 recruits components of the actin polymerizing machinery	yes	reactome/R-HSA-8868230.md	SNX9 recruits components of the actin polymerizing machinery	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	77	R-HSA-8868236	BAR domain proteins recruit dynamin	yes	reactome/R-HSA-8868236.md	BAR domain proteins recruit dynamin	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	78	R-HSA-8868648	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	yes	reactome/R-HSA-8868648.md	SYNJ hydrolyze PI(4,5)P2 to PI(4)P	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	79	R-HSA-8868651	Endophilins recruit synaptojanins to the clathrin-coated pit	yes	reactome/R-HSA-8868651.md	Endophilins recruit synaptojanins to the clathrin-coated pit	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	80	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	81	R-HSA-917807	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane	yes	reactome/R-HSA-917807.md	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	82	R-HSA-917814	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane	yes	reactome/R-HSA-917814.md	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	83	R-HSA-917839	apo-Transferrin dissociates from the receptor complex	yes	reactome/R-HSA-917839.md	apo-Transferrin dissociates from the receptor complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	84	R-HSA-917987	TFRC dimer binds 2xholoTF	yes	reactome/R-HSA-917987.md	TFRC dimer binds 2xholoTF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TfR1 is localized to the plasma membrane as a component of the Reactome transferrin endocytosis / iron-uptake reactions. Plasma membrane is the correct location for the cell-surface receptor.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	100	R-HSA-8868658	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	yes	reactome/R-HSA-8868658.md	HSPA8-mediated ATP hydrolysis promotes vesicle uncoating	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	101	R-HSA-8868659	Clathrin recruits auxilins to the clathrin-coated vesicle	yes	reactome/R-HSA-8868659.md	Clathrin recruits auxilins to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	102	R-HSA-8868660	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	yes	reactome/R-HSA-8868660.md	Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	103	R-HSA-8868661	Dynamin-mediated GTP hydrolysis promotes vesicle scission	yes	reactome/R-HSA-8868661.md	Dynamin-mediated GTP hydrolysis promotes vesicle scission	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	104	R-HSA-8869438	Dissociation of clathrin-associated proteins	yes	reactome/R-HSA-8869438.md	Dissociation of clathrin-associated proteins	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	105	R-HSA-8871193	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	yes	reactome/R-HSA-8871193.md	Dissociation of AAK1 and dephosphorylation of AP-2 mu2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	106	R-HSA-8871194	RAB5 and GAPVD1 bind AP-2	yes	reactome/R-HSA-8871194.md	RAB5 and GAPVD1 bind AP-2	Homo sapiens	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS	located_in	CC	false		ACCEPT	During clathrin-mediated internalization of the transferrin-TfR1 complex, TfR1 resides in the membrane of clathrin-coated endocytic vesicles. This Reactome (TAS) annotation captures a step of the iron-uptake cycle.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	107	R-HSA-917807	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane	yes	reactome/R-HSA-917807.md	holoTF:TFRC dimer translocates from plasma membrane to endosome membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	As an integral membrane protein, TfR1 is present in the endosome membrane during the transferrin cycle, where iron is released at acidic pH before receptor recycling. This Reactome (TAS) annotation captures the endosomal step.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	108	R-HSA-917814	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane	yes	reactome/R-HSA-917814.md	apoTF:TFRC dimer translocates from endosome membrane to plasma membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	As an integral membrane protein, TfR1 is present in the endosome membrane during the transferrin cycle, where iron is released at acidic pH before receptor recycling. This Reactome (TAS) annotation captures the endosomal step.
human	TFRC	genes/human/TFRC/TFRC-ai-review.yaml	TFRC	P02786	NCBITaxon:9606	Homo sapiens	109	R-HSA-917835	Fe3+ dissociates from holoTF:TFRC dimer	yes	reactome/R-HSA-917835.md	Fe3+ dissociates from holoTF:TFRC dimer	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	As an integral membrane protein, TfR1 is present in the endosome membrane during the transferrin cycle, where iron is released at acidic pH before receptor recycling. This Reactome (TAS) annotation captures the endosomal step.
human	TH	genes/human/TH/TH-ai-review.yaml	TH	P07101	NCBITaxon:9606	Homo sapiens	29	R-HSA-209823	Tyrosine is hydroxylated to dopa	yes	reactome/R-HSA-209823.md	Tyrosine is hydroxylated to dopa	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-traceable assertion of the cytosolic location where TH hydroxylates tyrosine to L-DOPA. Correct core location.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	87	R-HSA-5173005	B3GALTL transfers glucose to O-fucosyl-proteins	yes	reactome/R-HSA-5173005.md	B3GALTL transfers glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	TSP1 transits through the ER lumen during biosynthesis as a secreted protein. It undergoes post-translational modifications including glycosylation and disulfide bond formation in the ER.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	88	R-HSA-5173192	POFUT2 transfers fucose to TSR domain-containing proteins	yes	reactome/R-HSA-5173192.md	POFUT2 transfers fucose to TSR domain-containing proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome evidence for TSP1 transit through ER lumen during biosynthesis.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	89	R-HSA-6785565	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	yes	reactome/R-HSA-6785565.md	Defective B3GALTL does not transfer glucose to O-fucosyl-proteins	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 presence in ER lumen during protein maturation and secretion.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	102	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	TSP1 is stored in platelet alpha granule lumen and released upon platelet activation. This is a well-established storage site.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	103	R-HSA-8936995	THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	yes	reactome/R-HSA-8936995.md	THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome evidence for TSP1 storage in platelet alpha granule lumen.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	104	R-HSA-265429	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1	yes	reactome/R-HSA-265429.md	THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 localization in the extracellular region.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	105	R-HSA-349603	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1)	yes	reactome/R-HSA-349603.md	Interaction of integrin alphaIIb beta 3 with THBS1 (Thrombospondin-1)	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 in extracellular region.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	106	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 in extracellular region.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	107	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 in extracellular region.
human	THBS1	genes/human/THBS1/THBS1-ai-review.yaml	THBS1	P07996	NCBITaxon:9606	Homo sapiens	108	R-NUL-2731112	Syndecan-1 binds THBS1	yes	reactome/R-NUL-2731112.md	Syndecan-1 binds THBS1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome evidence for TSP1 in extracellular region.
human	THBS2	genes/human/THBS2/THBS2-ai-review.yaml	THBS2	P35442	NCBITaxon:9606	Homo sapiens	19	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PDGF binding to ECM proteins. THBS2 is appropriately annotated as extracellular based on its known secretion and ECM localization.
human	THBS3	genes/human/THBS3/THBS3-ai-review.yaml	THBS3	P49746	NCBITaxon:9606	Homo sapiens	12	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	"This annotation derives from Reactome pathway ""PDGF binds to extracellular matrix proteins"" which describes thrombospondin binding to PDGF in the ECM context."
human	THBS4	genes/human/THBS4/THBS4-ai-review.yaml	THBS4	P35443	NCBITaxon:9606	Homo sapiens	27	R-HSA-382054	PDGF binds to extracellular matrix proteins	yes	reactome/R-HSA-382054.md	PDGF binds to extracellular matrix proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TSP-4 is in the extracellular region where it can bind to PDGF according to Reactome pathway annotation.
human	THG1L	genes/human/THG1L/THG1L-ai-review.yaml	THG1L	Q9NWX6	NCBITaxon:9606	Homo sapiens	17	R-HSA-6782434	THG1L transfers GMP to 5' end of tRNA(His)	yes	reactome/R-HSA-6782434.md	THG1L transfers GMP to 5' end of tRNA(His)	Homo sapiens	GO:0006400	tRNA modification	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation ('THG1L transfers GMP to 5' end of tRNA(His)') mapped to the broad tRNA modification process. The event is more precisely tRNA 5'-end processing, but the annotation reflects the correct reaction.
human	THG1L	genes/human/THG1L/THG1L-ai-review.yaml	THG1L	Q9NWX6	NCBITaxon:9606	Homo sapiens	24	R-HSA-6782434	THG1L transfers GMP to 5' end of tRNA(His)	yes	reactome/R-HSA-6782434.md	THG1L transfers GMP to 5' end of tRNA(His)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome author-stated cytosolic localization, where cytosolic tRNA(His) guanylylation would occur. Consistent with the original ICF45 cytoplasmic characterization.
human	THTPA	genes/human/THTPA/THTPA-ai-review.yaml	THTPA	Q9BU02	NCBITaxon:9606	Homo sapiens	14	R-HSA-965067	THTPA:Mg2+ hydrolyzes ThTP to TDP	yes	reactome/R-HSA-965067.md	THTPA:Mg2+ hydrolyzes ThTP to TDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Cytosolic localization asserted by the Reactome reaction ""THTPA:Mg2+ hydrolyzes ThTP to TDP"" in the Vitamin B1 metabolism pathway. Consistent with the UniProt soluble/cytoplasm annotation. Correct."
human	TIA1	genes/human/TIA1/TIA1-ai-review.yaml	TIA1	P31483	NCBITaxon:9606	Homo sapiens	35	R-HSA-6803527	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	yes	reactome/R-HSA-6803527.md	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for nucleoplasm localization
human	TIAL1	genes/human/TIAL1/TIAL1-ai-review.yaml	TIAL1	Q01085	NCBITaxon:9606	Homo sapiens	26	R-HSA-6803527	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	yes	reactome/R-HSA-6803527.md	ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places TIAL1 in the nucleoplasmic FGFR2 alternative-splicing reaction context.
human	TIMM21	genes/human/TIMM21/TIMM21-ai-review.yaml	TIMM21	Q9BVV7	NCBITaxon:9606	Homo sapiens	12	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Supported as TIMM21 function at the inner-membrane/intermembrane-space interface during TOM-TIM23 handover, not as a soluble IMS protein.
human	TIMM21	genes/human/TIMM21/TIMM21-ai-review.yaml	TIMM21	Q9BVV7	NCBITaxon:9606	Homo sapiens	13	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Supported as TIMM21 function at the inner-membrane/intermembrane-space interface during TOM-TIM23 handover, not as a soluble IMS protein.
human	TIMM21	genes/human/TIMM21/TIMM21-ai-review.yaml	TIMM21	Q9BVV7	NCBITaxon:9606	Homo sapiens	16	R-HSA-9865412	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	yes	reactome/R-HSA-9865412.md	TIMM21 carries COX4, COX5A, COX6C to MT-CO1:MITRAC	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Correct. TIMM21 is associated with the mitochondrial inner membrane as part of TIM23-related assemblies.
human	TIMM21	genes/human/TIMM21/TIMM21-ai-review.yaml	TIMM21	Q9BVV7	NCBITaxon:9606	Homo sapiens	17	R-HSA-9865449	Metallochaperone inserts Cu2+ into MT-CO1	yes	reactome/R-HSA-9865449.md	Metallochaperone inserts Cu2+ into MT-CO1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Correct. TIMM21 is associated with the mitochondrial inner membrane as part of TIM23-related assemblies.
human	TIMM21	genes/human/TIMM21/TIMM21-ai-review.yaml	TIMM21	Q9BVV7	NCBITaxon:9606	Homo sapiens	18	R-HSA-9865579	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	yes	reactome/R-HSA-9865579.md	MT-CO1 and MT-CO2 complexes associate, installing heme moieties	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Correct. TIMM21 is associated with the mitochondrial inner membrane as part of TIM23-related assemblies.
human	TIMM22	genes/human/TIMM22/TIMM22-ai-review.yaml	TIMM22	Q9Y584	NCBITaxon:9606	Homo sapiens	24	R-HSA-1955380	TIMM9:TIMM10 transfers proteins to TIMM22	yes	reactome/R-HSA-1955380.md	TIMM9:TIMM10 transfers proteins to TIMM22	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Correct. TIMM22 is a mitochondrial inner-membrane component of the TIM22 carrier translocase.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	12	R-HSA-6799178	Intermediate 1 binds HP subcomplex to form Intermediate 2	yes	reactome/R-HSA-6799178.md	Intermediate 1 binds HP subcomplex to form Intermediate 2	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization, from a step of the Complex I biogenesis pathway. This is the most precise, correct location for TIMMDC1 and is consistent with its multi-pass topology. Core location.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	13	R-HSA-6799179	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	yes	reactome/R-HSA-6799179.md	Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization from the Complex I biogenesis pathway. Correct, precise location. Redundant with the other Reactome TAS inner-membrane annotations.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	14	R-HSA-6799191	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	yes	reactome/R-HSA-6799191.md	Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization from the Complex I biogenesis pathway. Correct, precise location.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	15	R-HSA-6799196	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	yes	reactome/R-HSA-6799196.md	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization from the Complex I biogenesis pathway (the step in which TIMMDC1/MCIA dissociate from the 980 kDa complex to yield mature Complex I). Correct, precise location.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	16	R-HSA-6799197	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	yes	reactome/R-HSA-6799197.md	ND4, ND5 bind the 550kDa complex to form the 815kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization from the Complex I biogenesis pathway. Correct, precise location.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	17	R-HSA-6799202	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	yes	reactome/R-HSA-6799202.md	The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner mitochondrial membrane localization from the Complex I biogenesis pathway. Correct, precise location.
human	TIMMDC1	genes/human/TIMMDC1/TIMMDC1-ai-review.yaml	TIMMDC1	Q9NPL8	NCBITaxon:9606	Homo sapiens	18	R-HSA-6799203	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	yes	reactome/R-HSA-6799203.md	IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome (TAS) inner mitochondrial membrane localization from the step ""IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1"", which directly documents TIMMDC1's incorporation into the Complex I assembly intermediate. Correct, precise location."
human	TK2	genes/human/TK2/TK2-ai-review.yaml	TK2	O00142	NCBITaxon:9606	Homo sapiens	18	R-HSA-73614	Pyrimidine salvage	yes	reactome/R-HSA-73614.md	Pyrimidine salvage	Homo sapiens	GO:0043097	pyrimidine nucleoside salvage	TAS	involved_in	BP	false		ACCEPT	Reactome TAS annotation to pyrimidine nucleoside salvage, capturing the core pathway role of TK2 as the pyrimidine deoxyribonucleoside kinase of the mitochondrial salvage pathway.
human	TK2	genes/human/TK2/TK2-ai-review.yaml	TK2	O00142	NCBITaxon:9606	Homo sapiens	25	R-HSA-109759	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]	yes	reactome/R-HSA-109759.md	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]	Homo sapiens	GO:0019206	nucleoside kinase activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	Reactome TAS annotation to the broad parent term nucleoside kinase activity for the TK2 reaction (deoxycytidine/thymidine/deoxyuridine + ATP => dCMP/TMP/dUMP + ADP).
human	TK2	genes/human/TK2/TK2-ai-review.yaml	TK2	O00142	NCBITaxon:9606	Homo sapiens	26	R-HSA-109759	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]	yes	reactome/R-HSA-109759.md	deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation localizing TK2 activity to the mitochondrial matrix, the most specific and correct compartment for this enzyme.
human	TKFC	genes/human/TKFC/TKFC-ai-review.yaml	TKFC	Q3LXA3	NCBITaxon:9606	Homo sapiens	14	R-HSA-70349	DAK dimer phosphorylates D-glyceraldehyde to form D-glyceraldehyde 3-phosphate	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization associated with the fructose-catabolism reaction in which the DAK dimer phosphorylates D-glyceraldehyde to glyceraldehyde 3-phosphate.
human	TKFC	genes/human/TKFC/TKFC-ai-review.yaml	TKFC	Q3LXA3	NCBITaxon:9606	Homo sapiens	15	R-HSA-913725	viral dsRNA binds IFIH1:TKFC	yes	reactome/R-HSA-913725.md	viral dsRNA binds IFIH1:TKFC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization associated with the IFIH1:TKFC / viral dsRNA sensing context; consistent with cytosolic TKFC.
human	TKFC	genes/human/TKFC/TKFC-ai-review.yaml	TKFC	Q3LXA3	NCBITaxon:9606	Homo sapiens	16	R-HSA-9754745	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates	yes	reactome/R-HSA-9754745.md	IFIH1:TKFC binds SARS-CoV-2 dsRNA intermediates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization in the SARS-CoV-2 innate-immune module (IFIH1:TKFC binding dsRNA intermediates); consistent with cytosolic TKFC.
human	TKFC	genes/human/TKFC/TKFC-ai-review.yaml	TKFC	Q3LXA3	NCBITaxon:9606	Homo sapiens	17	R-HSA-9755244	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1	yes	reactome/R-HSA-9755244.md	SARS-CoV-2 nsp3 deISGylates ISGylated IFIH1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization in a SARS-CoV-2 innate-immune deISGylation module; consistent with cytosolic TKFC.
human	TKT	genes/human/TKT/TKT-ai-review.yaml	TKT	P29401	NCBITaxon:9606	Homo sapiens	24	R-HSA-163741	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate	yes	reactome/R-HSA-163741.md	D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the transketolase reaction (G3P + sedoheptulose-7-P <-> xylulose-5-P + ribose-5-P) in the cytosol. Consistent with the cytosolic non-oxidative PPP.
human	TKT	genes/human/TKT/TKT-ai-review.yaml	TKT	P29401	NCBITaxon:9606	Homo sapiens	25	R-HSA-163751	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate	yes	reactome/R-HSA-163751.md	D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the transketolase reaction (G3P + fructose-6-P <-> xylulose-5-P + erythrose-4-P) in the cytosol. Consistent with the cytosolic non-oxidative PPP.
human	TKT	genes/human/TKT/TKT-ai-review.yaml	TKT	P29401	NCBITaxon:9606	Homo sapiens	26	R-HSA-71324	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate	yes	reactome/R-HSA-71324.md	ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the transketolase reaction (ribose-5-P + xylulose-5-P <-> sedoheptulose-7-P + G3P) in the cytosol. Consistent with the cytosolic non-oxidative PPP.
human	TKT	genes/human/TKT/TKT-ai-review.yaml	TKT	P29401	NCBITaxon:9606	Homo sapiens	27	R-HSA-71335	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate	yes	reactome/R-HSA-71335.md	xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion placing the transketolase reaction (xylulose-5-P + erythrose-4-P <-> G3P + fructose-6-P) in the cytosol. Consistent with the cytosolic non-oxidative PPP.
human	TKT	genes/human/TKT/TKT-ai-review.yaml	TKT	P29401	NCBITaxon:9606	Homo sapiens	28	R-HSA-9761852	NFE2L2-dependent TKT gene expression	yes	reactome/R-HSA-9761852.md	NFE2L2-dependent TKT gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable assertion (NFE2L2-dependent TKT gene expression context) placing TKT in the cytosol. Consistent with the cytosolic localization of the enzyme.
human	TMEM63A	genes/human/TMEM63A/TMEM63A-ai-review.yaml	TMEM63A	O94886	NCBITaxon:9606	Homo sapiens	29	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TMEM63A reaches the plasma membrane, where its stretch-activated currents are recorded and where it acts in oligodendrocytes.
human	TMEM63A	genes/human/TMEM63A/TMEM63A-ai-review.yaml	TMEM63A	O94886	NCBITaxon:9606	Homo sapiens	30	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TMEM63A reaches the plasma membrane, where its stretch-activated currents are recorded and where it acts in oligodendrocytes.
human	TMEM63A	genes/human/TMEM63A/TMEM63A-ai-review.yaml	TMEM63A	O94886	NCBITaxon:9606	Homo sapiens	31	R-HSA-6799350	Exocytosis of specific granule membrane proteins	yes	reactome/R-HSA-6799350.md	Exocytosis of specific granule membrane proteins	Homo sapiens	GO:0035579	specific granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Specific granule membrane, from Reactome's neutrophil degranulation pathway.
human	TMEM63A	genes/human/TMEM63A/TMEM63A-ai-review.yaml	TMEM63A	O94886	NCBITaxon:9606	Homo sapiens	32	R-HSA-6798747	Exocytosis of tertiary granule membrane proteins	yes	reactome/R-HSA-6798747.md	Exocytosis of tertiary granule membrane proteins	Homo sapiens	GO:0070821	tertiary granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Tertiary granule membrane, from Reactome's neutrophil degranulation pathway.
human	TMEM67	genes/human/TMEM67/TMEM67-ai-review.yaml	TMEM67	Q5HYA8	NCBITaxon:9606	Homo sapiens	18	R-HSA-5617816	RAB3IP stimulates nucleotide exchange on RAB8A	yes	reactome/R-HSA-5617816.md	RAB3IP stimulates nucleotide exchange on RAB8A	Homo sapiens	GO:0060170	ciliary membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-5617816 (RAB3IP stimulates nucleotide exchange on RAB8A). TMEM67 is placed at the ciliary membrane in the context of cilium assembly pathways. TMEM67 is a transmembrane protein that spans the ciliary membrane at the transition zone. This annotation is correct but less specific than transition zone.
human	TMEM67	genes/human/TMEM67/TMEM67-ai-review.yaml	TMEM67	Q5HYA8	NCBITaxon:9606	Homo sapiens	19	R-HSA-5626681	Recruitment of transition zone proteins	yes	reactome/R-HSA-5626681.md	Recruitment of transition zone proteins	Homo sapiens	GO:0060170	ciliary membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-5626681 (Recruitment of transition zone proteins). TMEM67 placed at the ciliary membrane in the context of transition zone protein recruitment. This is a duplicate of the same GO term with a different Reactome source.
human	TMEM67	genes/human/TMEM67/TMEM67-ai-review.yaml	TMEM67	Q5HYA8	NCBITaxon:9606	Homo sapiens	20	R-HSA-5638009	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	yes	reactome/R-HSA-5638009.md	CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body	Homo sapiens	GO:0060170	ciliary membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-5638009 (CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body). TMEM67 placed at the ciliary membrane in the context of vesicle recruitment to the basal body. This is a third Reactome pathway source for the same GO term.
human	TMF1	genes/human/TMF1/TMF1-ai-review.yaml	TMF1	P82094	NCBITaxon:9606	Homo sapiens	16	R-HSA-6811431	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	yes	reactome/R-HSA-6811431.md	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS from Reactome ""RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles"". Reflects the Reactome cytosolic-pool placeholder for tethering factors. The diffuse cytoplasmic distribution observed under low-serum conditions (PMID:15467733) is real but the protein is concentrated at Golgi membranes. Keep as non-core."
human	TMF1	genes/human/TMF1/TMF1-ai-review.yaml	TMF1	P82094	NCBITaxon:9606	Homo sapiens	17	R-HSA-6814091	ARL1 recruits TGN Golgin homodimers	yes	reactome/R-HSA-6814091.md	ARL1 recruits TGN Golgin homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS from Reactome ""ARL1 recruits TGN Golgin homodimers"". Same comment as the previous cytosol annotation - reflects the Reactome cytosolic-pool placeholder. Keep as non-core."
human	TMF1	genes/human/TMF1/TMF1-ai-review.yaml	TMF1	P82094	NCBITaxon:9606	Homo sapiens	18	R-HSA-6814682	Fusion of early-endosome derived vesicles at the TGN	yes	reactome/R-HSA-6814682.md	Fusion of early-endosome derived vesicles at the TGN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	"TAS from Reactome ""Fusion of early-endosome derived vesicles at the TGN"". Same comment - Reactome placeholder for the cytosolic tethering pool. Keep as non-core."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	73	R-HSA-5357905	Regulation of TNFR1 signaling	yes	reactome/R-HSA-5357905.md	Regulation of TNFR1 signaling	Homo sapiens	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	"TAS from Reactome pathway ""Regulation of TNFR1 signaling"". A20 is a key component of TNFR1 signaling regulation, editing ubiquitin chains on RIPK1 in the TNF receptor complex."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	74	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	"TAS from Reactome ""Deubiquitination"" pathway. Core enzymatic function."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	75	R-HSA-168638	NOD1/2 Signaling Pathway	yes	reactome/R-HSA-168638.md	NOD1/2 Signaling Pathway	Homo sapiens	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	"TAS from Reactome ""NOD1/2 Signaling Pathway"". A20 participates in NLR signaling by negatively regulating NOD1/2 pathway activation."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	78	R-HSA-5357845	K63polyUb-RIPK1 is deubiquitinated	yes	reactome/R-HSA-5357845.md	K63polyUb-RIPK1 is deubiquitinated	Homo sapiens	GO:0061578	K63-linked deubiquitinase activity	TAS	enables	MF	false		ACCEPT	"TAS from Reactome ""K63polyUb-RIPK1 is deubiquitinated"". A20 removes K63-linked polyubiquitin from RIPK1."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	79	R-HSA-5690856	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1	yes	reactome/R-HSA-5690856.md	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1	Homo sapiens	GO:0061578	K63-linked deubiquitinase activity	TAS	enables	MF	false		ACCEPT	"TAS from Reactome ""TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1""."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	80	R-HSA-8869506	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	yes	reactome/R-HSA-8869506.md	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	Homo sapiens	GO:0061578	K63-linked deubiquitinase activity	TAS	enables	MF	false		ACCEPT	"TAS from Reactome ""TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6"". A20 also deubiquitinates K63-linked chains on TRAF6 as part of a complex."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	83	R-HSA-5357845	K63polyUb-RIPK1 is deubiquitinated	yes	reactome/R-HSA-5357845.md	K63polyUb-RIPK1 is deubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. A20 functions in the cytosol at receptor-proximal signaling complexes.
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	84	R-HSA-5690827	TNFAIP3 (A20) ubiquitinates RIPK1	yes	reactome/R-HSA-5690827.md	TNFAIP3 (A20) ubiquitinates RIPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFAIP3 (A20) ubiquitinates RIPK1""."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	85	R-HSA-5690845	TNIPs bind TNFAIP3 (A20)	yes	reactome/R-HSA-5690845.md	TNIPs bind TNFAIP3 (A20)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNIPs bind TNFAIP3 (A20)""."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	86	R-HSA-5690856	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1	yes	reactome/R-HSA-5690856.md	TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for K63polyUb-RIPK1 deubiquitination in cytosol.
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	87	R-HSA-5690870	OTUD7B,TNFAIP3 deubiquitinates TRAF6	yes	reactome/R-HSA-5690870.md	OTUD7B,TNFAIP3 deubiquitinate TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for TRAF6 deubiquitination in cytosol.
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	88	R-HSA-5693055	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	yes	reactome/R-HSA-5693055.md	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes""."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	89	R-HSA-5693108	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	yes	reactome/R-HSA-5693108.md	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for K48-linked ubiquitination of RIPK1 in cytosol.
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	90	R-HSA-688136	TNFAIP3 (A20) deubiquitinates RIP2	yes	reactome/R-HSA-688136.md	TNFAIP3 (A20) deubiquitinates RIP2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFAIP3 (A20) deubiquitinates RIP2""."
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	91	R-HSA-8869506	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	yes	reactome/R-HSA-8869506.md	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for TRAF6 deubiquitination complex in cytosol.
human	TNFAIP3	genes/human/TNFAIP3/TNFAIP3-ai-review.yaml	TNFAIP3	P21580	NCBITaxon:9606	Homo sapiens	92	R-HSA-937337	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	yes	reactome/R-HSA-937337.md	TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination""."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	68	R-HSA-3371353	Reactome pathway - TNFR1-induced signaling	yes	reactome/R-HSA-3371353.md	Soluble TNF-α binds TNFR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome reaction ""Soluble TNF-alpha binds TNFR1"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	69	R-HSA-5357757	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357757.md	BIRC(cIAP1/2) ubiquitinates RIPK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""BIRC(cIAP1/2) ubiquitinates RIPK1"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	70	R-HSA-5357776	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357776.md	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFR1 complex recruits IKK"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	71	R-HSA-5357780	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357780.md	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFR1 complex recruits BIRC2/3"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	72	R-HSA-5357845	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357845.md	K63polyUb-RIPK1 is deubiquitinated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""K63polyUb-RIPK1 is deubiquitinated"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	73	R-HSA-5357860	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357860.md	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFR1 complex recruits TAK1 complex"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	74	R-HSA-5357904	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357904.md	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNFR1 complex binds LUBAC"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	75	R-HSA-5357928	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5357928.md	CLIP3 and CYLD bind TNF signaling complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""CLIP3 and CYLD bind TNF signaling complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	76	R-HSA-5626953	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5626953.md	TNF-α:TNFR1 binds DENN/MADD	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNF-alpha:TNFR1 binds DENN/MADD"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	77	R-HSA-5626981	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5626981.md	TNF-α:TNFR1:NSMAF:GNB2L1 associates with SMPD2,3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for neutral sphingomyelinase pathway. Plasma membrane is correct.
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	78	R-HSA-5626982	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5626982.md	TNF-α:TNFR1:NSMAF binds RACK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for NSMAF-RACK1 binding. Plasma membrane is correct.
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	79	R-HSA-5626988	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5626988.md	TNF-α:TNFR1 binds NSMAF	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for NSMAF binding. Plasma membrane is correct.
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	80	R-HSA-5634221	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5634221.md	TRAF1 binds TRAF2 within TNFR1 signaling complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TRAF1 binds TRAF2 within TNFR1 signaling complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	81	R-HSA-5669097	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5669097.md	LTA trimer binds TNFRSF1A,1B,14	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""LTA trimer binds TNFRSF1A,1B,14"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	82	R-HSA-5693055	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5693055.md	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TAX1BP1:A20 binds RIPK1 complexes"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	83	R-HSA-5693108	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-5693108.md	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""A20 ubiquitinates RIPK1"". Plasma membrane is correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	84	R-HSA-83582	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-83582.md	TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TRADD:TRAF2:RIP1 dissociates from TNFR1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	85	R-HSA-83656	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-83656.md	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TNF:TNFR1 binds TRADD, TRAF2 and RIPK1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	86	R-HSA-83660	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-83660.md	Membrane-anchored TNF-α binds TNFR1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""Membrane-anchored TNF-alpha binds TNFR1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	87	R-HSA-9793679	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9793679.md	LUBAC ubiquitinates RIPK1 at K627	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""LUBAC ubiquitinates RIPK1 at K627"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	88	R-HSA-9793680	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9793680.md	OPTN binds polyUb-RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""OPTN binds polyUb-RIPK1 within TNFR1 complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	89	R-HSA-9796342	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9796342.md	MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""MIB2 binds RIPK1 within TNFR1 complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	90	R-HSA-9796346	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9796346.md	MIB2 ubiquitinates RIPK1 at K377, K604, K634	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""MIB2 ubiquitinates RIPK1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	91	R-HSA-9796379	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9796379.md	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""CYLD:SPATA2:LUBAC binds TNFR1 complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	92	R-HSA-9817362	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9817362.md	SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome for LUBAC-mediated RIPK1 ubiquitination. Plasma membrane correct.
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	93	R-HSA-9817397	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9817397.md	TBK1, IKBKE phosphorylate RIPK1 at T189	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TBK1/IKBKE phosphorylate RIPK1 at T189"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	94	R-HSA-9817400	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9817400.md	CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""CYLD hydrolyses K63polyUb on RIPK1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	95	R-HSA-9817411	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9817411.md	TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""TBK1/IKBKE binds Met1-polyUb in TNFR1 complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	96	R-HSA-9818789	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9818789.md	CHUK, IKBKB phosphorylate RIPK1 at S25	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""CHUK/IKBKB phosphorylate RIPK1 at S25"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	97	R-HSA-9818975	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9818975.md	CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""CYLD hydrolyses M1polyUb on RIPK1"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	98	R-HSA-9824874	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-9824874.md	OPTN recruits CYLD to the TNFR1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	"TAS from Reactome ""OPTN recruits CYLD to TNFR1 complex"". Plasma membrane correct."
human	TNFRSF1A	genes/human/TNFRSF1A/TNFRSF1A-ai-review.yaml	TNFRSF1A	P19438	NCBITaxon:9606	Homo sapiens	109	R-HSA-6785047	Reactome pathway - TNFR1 signaling	yes	reactome/R-HSA-6785047.md	IL10 positively regulates extracellular inflammatory mediators	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	TAS from Reactome IL-10 signaling pathway. The soluble TNFR1 ectodomain is found in the extracellular region.
human	TNFRSF21	genes/human/TNFRSF21/TNFRSF21-ai-review.yaml	TNFRSF21	O75509	NCBITaxon:9606	Homo sapiens	46	R-HSA-1989771	Expression of TNFRSF21	yes	reactome/R-HSA-1989771.md	Expression of TNFRSF21	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	DR6 is a type I transmembrane TNFRSF member displayed at the cell surface; plasma membrane localisation is confirmed by immunofluorescence, by mutagenesis that traps the protein intracellularly, and by orthology.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	54	R-HSA-4641257	Degradation of AXIN	yes	reactome/R-HSA-4641257.md	Degradation of AXIN	Homo sapiens	GO:0090263	positive regulation of canonical Wnt signaling pathway	TAS	involved_in	BP	false		ACCEPT	positive regulation of canonical Wnt signaling pathway is a canonical TNKS pathway output through AXIN PARylation.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	55	R-HSA-3640858	Tankyrase ADP-ribosylates AXIN	yes	reactome/R-HSA-3640858.md	Tankyrase ADP-ribosylates AXIN	Homo sapiens	GO:0003950	NAD+ poly-ADP-ribosyltransferase activity	TAS	enables	MF	false		ACCEPT	NAD+ poly-ADP-ribosyltransferase activity is a core TNKS catalytic molecular function.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	56	R-HSA-8948800	TNKS and TNKS2 PARylate PTEN	yes	reactome/R-HSA-8948800.md	TNKS and TNKS2 PARylate PTEN	Homo sapiens	GO:0003950	NAD+ poly-ADP-ribosyltransferase activity	TAS	enables	MF	false		ACCEPT	NAD+ poly-ADP-ribosyltransferase activity is a core TNKS catalytic molecular function.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	83	R-HSA-3640844	RNF146 binds RibC-AXIN:TNKS complex	yes	reactome/R-HSA-3640844.md	RNF146 binds RibC-AXIN:TNKS complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	84	R-HSA-3640858	Tankyrase ADP-ribosylates AXIN	yes	reactome/R-HSA-3640858.md	Tankyrase ADP-ribosylates AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	85	R-HSA-3640861	RNF146 ubiquitinates ADP-ribosylated AXIN	yes	reactome/R-HSA-3640861.md	RNF146 ubiquitinates ADP-ribosylated AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	86	R-HSA-3640862	Tankyrase binds AXIN	yes	reactome/R-HSA-3640862.md	Tankyrase binds AXIN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	87	R-HSA-3640872	USP34 deubiquitinates AXIN1,AXIN2	yes	reactome/R-HSA-3640872.md	USP34 deubiquitinates AXIN1,AXIN2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	88	R-HSA-3640874	Ub-RibC-AXIN is degraded by the proteasome	yes	reactome/R-HSA-3640874.md	Ub-RibC-AXIN is degraded by the proteasome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	89	R-HSA-5262606	XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling	yes	reactome/R-HSA-5262606.md	XAV939 binds tankyrase to stabilize axin and inhibit WNT signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TNKS	genes/human/TNKS/TNKS-ai-review.yaml	TNKS	O95271	NCBITaxon:9606	Homo sapiens	90	R-HSA-8948800	TNKS and TNKS2 PARylate PTEN	yes	reactome/R-HSA-8948800.md	TNKS and TNKS2 PARylate PTEN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TNKS multi-compartment activity.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	52	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular region is inconsistent with the reviewed intracellular adaptor/endosomal functions of TOLLIP.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	53	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Extracellular region is inconsistent with the reviewed intracellular adaptor/endosomal functions of TOLLIP.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	54	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Azurophil granule lumen is a context-specific secretory-granule annotation and is not supported as a functional TOLLIP location.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	55	R-HSA-6798749	Exocytosis of specific granule lumen proteins	yes	reactome/R-HSA-6798749.md	Exocytosis of specific granule lumen proteins	Homo sapiens	GO:0035580	specific granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Specific granule lumen is a context-specific secretory-granule annotation and is not supported as a functional TOLLIP location.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	61	R-HSA-446634	IRAK4 is activated by autophosphorylation	yes	reactome/R-HSA-446634.md	IRAK4 is activated by autophosphorylation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	62	R-HSA-446684	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation	yes	reactome/R-HSA-446684.md	IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	63	R-HSA-446692	IRAK1 binds to MYD88 within the IL1R complex	yes	reactome/R-HSA-446692.md	IRAK1 binds to MYD88 within the IL1R complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	64	R-HSA-446694	IRAK4 phosphorylates IRAK1	yes	reactome/R-HSA-446694.md	IRAK4 phosphorylates IRAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	65	R-HSA-446701	IRAK4-activated IRAK1 autophosphorylates	yes	reactome/R-HSA-446701.md	IRAK4-activated IRAK1 autophosphorylates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	66	R-HSA-446862	Hyperphosphorylated IRAK1 associates with TRAF6	yes	reactome/R-HSA-446862.md	Hyperphosphorylated IRAK1 associates with TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	67	R-HSA-446868	The Interleukin 1 receptor complex binds Tollip	yes	reactome/R-HSA-446868.md	The Interleukin 1 receptor complex binds Tollip	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOLLIP	genes/human/TOLLIP/TOLLIP-ai-review.yaml	TOLLIP	Q9H0E2	NCBITaxon:9606	Homo sapiens	68	R-HSA-446894	TRAF6 binding leads to IRAK1:TRAF6 release	yes	reactome/R-HSA-446894.md	TRAF6 binding leads to IRAK1:TRAF6 release	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TOLLIP acting as a soluble adaptor recruited to endosomal and receptor-signaling compartments.
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	26	R-HSA-5205649	p62 links damaged mitochondria to LC3	yes	reactome/R-HSA-5205649.md	p62 links damaged mitochondria to LC3	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-5205649 ""p62 links damaged mitochondria to LC3."" TOMM20 is placed at the mitochondrial outer membrane in this mitophagy pathway, which is correct. TOMM20 is a ubiquitination substrate of PRKN during mitophagy."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	27	R-HSA-5205663	LC3 binds the autophagosome membrane Atg5-Atg12 complex	yes	reactome/R-HSA-5205663.md	LC3 binds the autophagosome membrane Atg5-Atg12 complex	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-5205663 ""LC3 binds the autophagosome membrane Atg5-Atg12 complex."" TOMM20 localization to mitochondrial outer membrane in this autophagy context is correct."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	28	R-HSA-5205673	p62 binds ubiquitinated mitochondrial substrates	yes	reactome/R-HSA-5205673.md	p62 binds ubiquitinated mitochondrial substrates	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-5205673 ""p62 binds ubiquitinated mitochondrial substrates."" TOMM20 is a known ubiquitination substrate on the mitochondrial outer membrane during mitophagy. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	29	R-HSA-9824888	OPTN, TBK1 bind ubiquitinated MOM proteins	yes	reactome/R-HSA-9824888.md	OPTN, TBK1 bind ubiquitinated MOM proteins	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9824888 ""OPTN, TBK1 bind ubiquitinated MOM proteins."" TOMM20 is a ubiquitinated MOM substrate. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	30	R-HSA-9824892	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	yes	reactome/R-HSA-9824892.md	MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9824892 ""MAP1LC3B binds p-S-OPTN bound to Ub-mitochondria."" TOMM20 at mitochondrial outer membrane in mitophagy context. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	31	R-HSA-9824894	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	yes	reactome/R-HSA-9824894.md	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9824894 ""TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins."" TOMM20 at mitochondrial outer membrane. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	32	R-HSA-9824897	p-S-TBK1 phosphorylates OPTN	yes	reactome/R-HSA-9824897.md	p-S-TBK1 phosphorylates OPTN	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9824897 ""p-S-TBK1 phosphorylates OPTN."" TOMM20 at mitochondrial outer membrane in the mitophagy signaling cascade. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	33	R-HSA-9834070	PRKN ubiquitinates MOM substrates	yes	reactome/R-HSA-9834070.md	PRKN ubiquitinates MOM substrates	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9834070 ""PRKN ubiquitinates MOM substrates."" TOMM20 is a direct ubiquitination substrate of PRKN on the mitochondrial outer membrane (PMID:24896179, PMID:25621951 per UniProt). Correct and specifically relevant."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	34	R-HSA-9840807	OPTN binds ATG9A	yes	reactome/R-HSA-9840807.md	OPTN binds ATG9A	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9840807 ""OPTN binds ATG9A."" TOMM20 at mitochondrial outer membrane in the mitophagy context. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	35	R-HSA-9834945	PINK1 phosphorylates Ub on MOM proteins	yes	reactome/R-HSA-9834945.md	PINK1 phosphorylates Ub on MOM proteins	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9834945 ""PINK1 phosphorylates Ub on MOM proteins."" The Reactome entry explicitly lists TOMM20 as one of the MOM proteins whose ubiquitin moieties are phosphorylated by PINK1. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	36	R-HSA-9835009	PRKN binds p-S-Ub:MOM proteins	yes	reactome/R-HSA-9835009.md	PRKN binds p-S-Ub:MOM proteins	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9835009 ""PRKN binds p-S-Ub:MOM proteins."" TOMM20 at mitochondrial outer membrane as a ubiquitinated substrate for PRKN binding. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	37	R-HSA-9835011	PINK1 phosphorylates PRKN at S65	yes	reactome/R-HSA-9835011.md	PINK1 phosphorylates PRKN at S65	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-9835011 ""PINK1 phosphorylates PRKN at S65."" TOMM20 at mitochondrial outer membrane in the context of PINK1 activation at the TOM complex. Correct localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	41	R-HSA-5696872	USP30 deubiquitinates Ub-MOM proteins	yes	reactome/R-HSA-5696872.md	USP30 deubiquitinates Ub-MOM proteins	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-5696872 ""USP30 deubiquitinates Ub-MOM proteins."" TOMM20 is a substrate of both PRKN (ubiquitination) and USP30 (deubiquitination) at the mitochondrial outer membrane (PMID:24896179). Correct and functionally relevant localization."
human	TOMM20	genes/human/TOMM20/TOMM20-ai-review.yaml	TOMM20	Q15388	NCBITaxon:9606	Homo sapiens	44	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-HSA-5205661 ""Pink1 is recruited from the cytoplasm to the mitochondria."" TOMM20 at the mitochondrial outer membrane in the context of PINK1 import. Recent evidence shows TOMM20 directly gates PINK1 activity and mediates tethering of TOM and TIM23 translocases upon mitochondrial stress (PMID:38416681 cited in UniProt). Correct and functionally relevant."
human	TOMM22	genes/human/TOMM22/TOMM22-ai-review.yaml	TOMM22	Q9NS69	NCBITaxon:9606	Homo sapiens	20	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct. TOMM22 is a single-pass mitochondrial outer membrane component of the TOM complex.
human	TOMM40	genes/human/TOMM40/TOMM40-ai-review.yaml	TOMM40	O96008	NCBITaxon:9606	Homo sapiens	23	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for PINK1 recruitment to mitochondria. Confirms TOMM40 at the outer membrane. Redundant with direct experimental evidence.
human	TOMM5	genes/human/TOMM5/TOMM5-ai-review.yaml	TOMM5	Q8N4H5	NCBITaxon:9606	Homo sapiens	9	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome places TOMM5 at the mitochondrial outer membrane in TOM/PINK1 pathway context. This agrees with the TOM core localization.
human	TOMM6	genes/human/TOMM6/TOMM6-ai-review.yaml	TOMM6	Q96B49	NCBITaxon:9606	Homo sapiens	10	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Reactome places TOMM6 at the mitochondrial outer membrane in TOM/PINK1 pathway context. This matches the structural TOM core localization.
human	TOMM7	genes/human/TOMM7/TOMM7-ai-review.yaml	TOMM7	Q9P0U1	NCBITaxon:9606	Homo sapiens	17	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Accepted. Reactome places TOMM7 at the mitochondrial outer membrane in TOM/PINK1 pathway context.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	33	R-HSA-5205661	Pink1 is recruited from the cytoplasm to the mitochondria	yes	reactome/R-HSA-5205661.md	Pink1 is recruited from the cytoplasm to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	34	R-HSA-9685281	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome	yes	reactome/R-HSA-9685281.md	SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	35	R-HSA-9709663	SARS-CoV-2 9b binds TOMM70	yes	reactome/R-HSA-9709663.md	SARS-CoV-2 9b binds TOMM70	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	36	R-HSA-9709787	SARS-CoV-1 9b binds TOMM70	yes	reactome/R-HSA-9709787.md	SARS-CoV-1 9b binds TOMM70	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	37	R-HSA-9709842	MAVS binds TOMM70	yes	reactome/R-HSA-9709842.md	MAVS binds TOMM70	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOMM70	genes/human/TOMM70/TOMM70-ai-review.yaml	TOMM70	O94826	NCBITaxon:9606	Homo sapiens	38	R-HSA-9709852	MAVS:TOMM70 recruits HSP90:TBK1:IRF3	yes	reactome/R-HSA-9709852.md	MAVS:TOMM70 recruits HSP90:TBK1:IRF3	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct localization. TOMM70 is an outer mitochondrial membrane TOM receptor/adaptor with a cytosol-facing TPR receptor domain.
human	TOP2A	genes/human/TOP2A/TOP2A-ai-review.yaml	TOP2A	P11388	NCBITaxon:9606	Homo sapiens	44	R-HSA-4641342	SUMOylation of TOP2A with SUMO1	yes	reactome/R-HSA-4641342.md	SUMOylation of TOP2A with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TOP2A localizes to nucleoplasm in interphase.
human	TOP2A	genes/human/TOP2A/TOP2A-ai-review.yaml	TOP2A	P11388	NCBITaxon:9606	Homo sapiens	45	R-HSA-4641350	PIAS4 SUMOylates TOP2A with SUMO2,3	yes	reactome/R-HSA-4641350.md	PIAS4 SUMOylates TOP2A with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TOP2A localizes to nucleoplasm in interphase.
human	TOP2A	genes/human/TOP2A/TOP2A-ai-review.yaml	TOP2A	P11388	NCBITaxon:9606	Homo sapiens	66	R-HSA-8964531	TOP2A gene gene expression is repressed by the DREAM complex	yes	reactome/R-HSA-8964531.md	TOP2A gene gene expression is repressed by the DREAM complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TOP2A localizes to nucleoplasm in interphase.
human	TOP2B	genes/human/TOP2B/TOP2B-ai-review.yaml	TOP2B	Q02880	NCBITaxon:9606	Homo sapiens	38	R-HSA-4641345	SUMOylation of TOP2B with SUMO1	yes	reactome/R-HSA-4641345.md	SUMOylation of TOP2B with SUMO1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway for SUMOylation of TOP2B with SUMO1. TOP2B is SUMOylated in the nucleoplasm as part of the SUMOylation of DNA replication proteins pathway.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	504	R-HSA-9836362	p-PKR dimer phosphorylates TP53 tetramer	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	529	R-HSA-2997706	MDM2 SUMOylates TP53 with SUMO2,3	yes	reactome/R-HSA-2997706.md	MDM2 SUMOylates TP53 with SUMO2,3	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	550	R-HSA-9723906	Defective TP53 does not tetramerize	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	636	R-HSA-5689950	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN	yes	reactome/R-HSA-5689950.md	USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	637	R-HSA-5689973	USP10,USP24,USP42 deubiquitinate TP53	yes	reactome/R-HSA-5689973.md	USP10,USP24,USP42 deubiquitinate TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	638	R-HSA-5690843	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	yes	reactome/R-HSA-5690843.md	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	639	R-HSA-6793685	Ubiquitinated TP53 translocates to the cytosol	yes	reactome/R-HSA-6793685.md	Ubiquitinated TP53 translocates to the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	640	R-HSA-8852351	GTSE1 promotes translocation of TP53 to the cytosol	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	641	R-HSA-8852354	GTSE1 facilitates proteasome-mediated degradation of TP53	yes	reactome/R-HSA-8852354.md	GTSE1 facilitates proteasome-mediated degradation of TP53	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	p53 localizes to cytosol as part of its nucleo-cytoplasmic shuttling.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	643	R-HSA-3222116	L3MBTL1 binds TP53 monomethylated on K382	yes	reactome/R-HSA-3222116.md	L3MBTL1 binds TP53 monomethylated on K382	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	644	R-HSA-3222237	SMYD2 methylates TP53	yes	reactome/R-HSA-3222237.md	SMYD2 methylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	645	R-HSA-5628871	BRD7 promotes EP300-mediated acetylation of TP53	yes	reactome/R-HSA-5628871.md	BRD7 promotes EP300-mediated acetylation of TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	646	R-HSA-6805638	KAT6A acetylates TP53	yes	reactome/R-HSA-6805638.md	KAT6A acetylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	647	R-HSA-6805730	SETD9 methylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	648	R-HSA-6805740	SETD8 methylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	649	R-HSA-6805755	EHMT1:EHMT2 dimethylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	650	R-HSA-6811508	ING2-bound EP300 acetylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	651	R-HSA-6805276	CDK5 phosphorylates TP53	yes	reactome/R-HSA-6805276.md	CDK5 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	652	R-HSA-6805399	TAF1 phosphorylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	653	R-HSA-6805103	AURKA phosphorylates TP53	yes	reactome/R-HSA-6805103.md	AURKA phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	654	R-HSA-6805109	CDK2 phosphorylates TP53	yes	reactome/R-HSA-6805109.md	CDK2 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	655	R-HSA-6805126	AURKB phosphorylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	656	R-HSA-3215310	USP7 deubiquitinates TP53 and counteracts MDM2	yes	reactome/R-HSA-3215310.md	USP7 deubiquitinates TP53 and counteracts MDM2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	657	R-HSA-6793685	Ubiquitinated TP53 translocates to the cytosol	yes	reactome/R-HSA-6793685.md	Ubiquitinated TP53 translocates to the cytosol	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	658	R-HSA-6804441	RNF34 or RFFL ubiquitinates phosphorylated TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	659	R-HSA-6804879	MDM2 ubiquitinates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	660	R-HSA-6805059	CK2:FACT phosphorylates TP53	yes	reactome/R-HSA-6805059.md	CK2:FACT phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	661	R-HSA-8852337	GTSE1 binds TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	662	R-HSA-8852351	GTSE1 promotes translocation of TP53 to the cytosol	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	663	R-HSA-9851077	JNK-dependent inhibition of TP53 ubiquitination	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	664	R-HSA-6804383	PRMT5 methylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	665	R-HSA-3215152	TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter	yes	reactome/R-HSA-3215152.md	TP53 in complex with EP300, PRMT1 and CARM1 binds the GADD45A promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	666	R-HSA-3215251	TP53INP1 and HIPK2 bind TP53	yes	reactome/R-HSA-3215251.md	TP53INP1 and HIPK2 bind TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	667	R-HSA-3222093	BRD7 binds TP53 and EP300	yes	reactome/R-HSA-3222093.md	BRD7 binds TP53 and EP300	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	668	R-HSA-3222128	NOC2L binds TP53	yes	reactome/R-HSA-3222128.md	NOC2L binds TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	669	R-HSA-3700981	TP53 family members bind the BAX promoter	yes	reactome/R-HSA-3700981.md	TP53 family members bind the BAX promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	670	R-HSA-3700997	TP53 binds the MDM2 gene	yes	reactome/R-HSA-3700997.md	TP53 binds the MDM2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	671	R-HSA-4331331	TP53 binds the PMAIP1 (NOXA) promoter	yes	reactome/R-HSA-4331331.md	TP53 binds the PMAIP1 (NOXA) promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	672	R-HSA-4331340	TP53 binds the BBC3 (PUMA) promoter	yes	reactome/R-HSA-4331340.md	TP53 binds the BBC3 (PUMA) promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	673	R-HSA-5633295	TP53 binds the NDRG1 gene promoter	yes	reactome/R-HSA-5633295.md	TP53 binds the NDRG1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	674	R-HSA-5633414	TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes	yes	reactome/R-HSA-5633414.md	TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	675	R-HSA-6791285	TP53 binds the BID gene promoter	yes	reactome/R-HSA-6791285.md	TP53 binds the BID gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	676	R-HSA-6791302	TP53 binds the AIFM2 gene promoter	yes	reactome/R-HSA-6791302.md	TP53 binds the AIFM2 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	677	R-HSA-6791327	TP53 binds the BCL2L14 gene	yes	reactome/R-HSA-6791327.md	TP53 binds the BCL2L14 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	678	R-HSA-6791349	TP53 binds the APAF1 gene promoter	yes	reactome/R-HSA-6791349.md	TP53 binds the APAF1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	679	R-HSA-6791387	TP53 binds the ARID3A gene	yes	reactome/R-HSA-6791387.md	TP53 binds the ARID3A gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	680	R-HSA-6796649	TP53 binds the CCNK gene	yes	reactome/R-HSA-6796649.md	TP53 binds the CCNK gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	681	R-HSA-6797766	TP53 binds the BIRC5 gene	yes	reactome/R-HSA-6797766.md	TP53 binds the BIRC5 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	682	R-HSA-6797993	TP53 and CREBBP bind BNIP3L gene	yes	reactome/R-HSA-6797993.md	TP53 and CREBBP bind BNIP3L gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	683	R-HSA-6798020	TP53 binds the BTG2 gene	yes	reactome/R-HSA-6798020.md	TP53 binds the BTG2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	684	R-HSA-6798082	TP53 family members bind the CASP1 gene	yes	reactome/R-HSA-6798082.md	TP53 family members bind the CASP1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	685	R-HSA-6798129	TP53 binds the CASP6 gene	yes	reactome/R-HSA-6798129.md	TP53 binds the CASP6 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	686	R-HSA-6798138	TP53 binds the CASP10 gene	yes	reactome/R-HSA-6798138.md	TP53 binds the CASP10 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	687	R-HSA-6798282	TP53 and E2F4 bind the CDC25C gene	yes	reactome/R-HSA-6798282.md	TP53 and E2F4 bind the CDC25C gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	688	R-HSA-6798304	TP53 binds the E2F7 gene	yes	reactome/R-HSA-6798304.md	TP53 binds the E2F7 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	689	R-HSA-6798374	DYRK2 phosphorylates TP53	yes	reactome/R-HSA-6798374.md	DYRK2 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	690	R-HSA-6799246	CHEK1 phosphorylates TP53	yes	reactome/R-HSA-6799246.md	CHEK1 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	691	R-HSA-6799409	HIPK2 phosphorylates TP53	yes	reactome/R-HSA-6799409.md	HIPK2 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	692	R-HSA-6799418	TP53 binds the TP53INP1 gene	yes	reactome/R-HSA-6799418.md	TP53 binds the TP53INP1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	693	R-HSA-6799462	TP53 family members bind the TP53I3 (PIG3) gene promoter	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	694	R-HSA-6799761	TP53 binds PPP1R13L	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	695	R-HSA-6799777	TP53 family members bind PPP1R13B or TP53BP2	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	696	R-HSA-6799815	TP53 family members bind the FAS gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	697	R-HSA-6800042	TP53 binds the IGFBP3 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	698	R-HSA-6800253	TP53 binds the BCL6 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	699	R-HSA-6800279	TP53 binds the PIDD1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	700	R-HSA-6800836	TP53 or TP63 binds the PERP gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	701	R-HSA-6801087	TP53 binds the RABGGTA gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	702	R-HSA-6801166	TP53 binds the STEAP3 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	703	R-HSA-6801209	TP53 binds the TRIAP1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	704	R-HSA-6801355	TP53 binds the NLRC4 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	705	R-HSA-6801641	TP53 binds the PLK2 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	706	R-HSA-6802165	TP53 binds the PLK3 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	707	R-HSA-6803391	TP53 binds the PCBP4 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	708	R-HSA-6803425	TP53 binds ZNF385A gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	709	R-HSA-6803719	TP53 binds ZNF385A	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	710	R-HSA-6803801	TP53 in complex with ZNF385A binds the CDKN1A promoter	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	711	R-HSA-6803858	TP53 binds the SFN gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	712	R-HSA-6803914	TP53 binds the RGCC gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	713	R-HSA-6803935	TP53 binds the PLAGL1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	714	R-HSA-6804191	TP53 binds the PRDM1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	715	R-HSA-6804242	TP53 binds the complex of JMY, EP300 and TTC5	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	716	R-HSA-6804379	PRMT5 binds TTC5	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	717	R-HSA-6804402	TP53 binds POU4F1	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	718	R-HSA-6804425	TP53 binds POU4F2	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	719	R-HSA-6805122	AURKB binds TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	720	R-HSA-6805285	PLK3 phosphorylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	721	R-HSA-6805620	KAT6A and PML bind TP53	yes	reactome/R-HSA-6805620.md	KAT6A and PML bind TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	722	R-HSA-6806408	TP53 binds the PMS2 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	723	R-HSA-6806412	TP53 and AP-1 bind the MSH2 promoter	yes	reactome/R-HSA-6806412.md	TP53 and AP-1 bind the MSH2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	724	R-HSA-6806413	TP53 binds the MLH1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	725	R-HSA-6806417	TP53 binds the DDB2 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	726	R-HSA-6806419	TP53 binds the FANCC gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	727	R-HSA-6811479	ING2 recruits EP300 to TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	728	R-HSA-69685	CHEK2 phosphorylates TP53	yes	reactome/R-HSA-69685.md	CHEK2 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	729	R-HSA-9710323	TP53 or TP63 binds the GSDME gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	730	R-HSA-9749464	TP53 binds the IKBIP gene promoter	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	731	R-HSA-9851076	p-T,Y MAPK8,9 bind TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	732	R-HSA-6798615	TP53 binds the TP53AIP1 gene	yes	reactome/R-HSA-6798615.md	TP53 binds the TP53AIP1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	752	R-HSA-3222259	PHF20 binds TP53 dimethylated on K370 and K382	yes	reactome/R-HSA-3222259.md	PHF20 binds TP53 dimethylated on K370 and K382	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	753	R-HSA-3239014	MAPKAPK5 phosphorylates TP53	yes	reactome/R-HSA-3239014.md	MAPKAPK5 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	755	R-HSA-264435	Dissociation of the COP1-p53 complex	yes	reactome/R-HSA-264435.md	Dissociation of the COP1-p53 complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	756	R-HSA-3221982	BANP binds TP53	yes	reactome/R-HSA-3221982.md	BANP binds TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	757	R-HSA-3222006	STK11 (LKB1) phosphorylates NUAK1	yes	reactome/R-HSA-3222006.md	STK11 (LKB1) phosphorylates NUAK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	758	R-HSA-3222020	NUAK1 phosphorylates TP53	yes	reactome/R-HSA-3222020.md	NUAK1 phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	759	R-HSA-3786258	TP53 binds the CDKN1A promoter	yes	reactome/R-HSA-3786258.md	TP53 binds the CDKN1A promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	760	R-HSA-4395236	TP53 binds promoters of MIR34 genes	yes	reactome/R-HSA-4395236.md	TP53 binds promoters of MIR34 genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	761	R-HSA-4647593	EP400 binds CDKN1A promoter	yes	reactome/R-HSA-4647593.md	EP400 binds CDKN1A promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	762	R-HSA-5628899	TP53 binds the TIGAR gene	yes	reactome/R-HSA-5628899.md	TP53 binds the TIGAR gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	763	R-HSA-5629187	TP53 binds regulatory elements of SESN1,2,3 genes	yes	reactome/R-HSA-5629187.md	TP53 binds regulatory elements of SESN1,2,3 genes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	764	R-HSA-5632759	TP53 binds the SCO2 gene	yes	reactome/R-HSA-5632759.md	TP53 binds the SCO2 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	765	R-HSA-5632887	TP53 binds the RRM2B gene	yes	reactome/R-HSA-5632887.md	TP53 binds the RRM2B gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	766	R-HSA-5632914	TP53 binds the GLS2 promoter	yes	reactome/R-HSA-5632914.md	TP53 binds the GLS2 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	767	R-HSA-5632939	TP53 binds the PTEN promoter	yes	reactome/R-HSA-5632939.md	TP53 binds the PTEN promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	768	R-HSA-5633460	MDM2 binds TP53	yes	reactome/R-HSA-5633460.md	MDM2 binds TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	769	R-HSA-5693609	ATM phosphorylates TP53 at S15	yes	reactome/R-HSA-5693609.md	ATM phosphorylates TP53 at S15	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	770	R-HSA-6789960	Expression of NDN,TP53	yes	reactome/R-HSA-6789960.md	Expression of NDN,TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	771	R-HSA-6791409	TP53 binds the CCNG1 gene	yes	reactome/R-HSA-6791409.md	TP53 binds the CCNG1 gene	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	772	R-HSA-6799332	ATR phosphorylates TP53	yes	reactome/R-HSA-6799332.md	ATR phosphorylates TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	773	R-HSA-6799431	TP53 binds HIPK1	yes	reactome/R-HSA-6799431.md	TP53 binds HIPK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	774	R-HSA-6804188	PRDM1 represses TP53 expression	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	775	R-HSA-6804762	TP53 forms homotetramers	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	776	R-HSA-6804996	p14ARF sequesters MDM2	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	777	R-HSA-6804998	p14ARF forms a ternary complex with MDM2 and TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	778	R-HSA-6805035	TP53 binds STK11 and NUAK1	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	779	R-HSA-6805470	AMPK phosphorylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	780	R-HSA-6805479	TP53RK phosphorylates TP53	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	781	R-HSA-8853911	VENTX stimulates TP53 gene expression	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	782	R-HSA-8952128	RUNX3 binds TP53	yes	reactome/R-HSA-8952128.md	RUNX3 binds TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TP53	genes/human/TP53/TP53-ai-review.yaml	TP53	P04637	NCBITaxon:9606	Homo sapiens	783	R-NUL-992753	p53 and Sin3a bind c-Myb	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	p53 is a nuclear transcription factor that localizes to the nucleoplasm.
human	TPH1	genes/human/TPH1/TPH1-ai-review.yaml	TPH1	P17752	NCBITaxon:9606	Homo sapiens	21	R-HSA-209828	Tryptophan is hydroxylated	yes	reactome/R-HSA-209828.md	Tryptophan is hydroxylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) placement of the tryptophan-hydroxylation reaction in the cytosol, consistent with TPH1 being a soluble cytosolic enzyme. Accepted as the (non-core) cellular component.
human	TPH1	genes/human/TPH1/TPH1-ai-review.yaml	TPH1	P17752	NCBITaxon:9606	Homo sapiens	22	R-HSA-9621048	TPH1 gene expression	yes	reactome/R-HSA-9621048.md	TPH1 gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol annotation associated with the TPH1 gene-expression event; consistent with the soluble cytosolic localization of the enzyme. Accepted as non-core cellular component (redundant with the other cytosol annotations).
human	TPH2	genes/human/TPH2/TPH2-ai-review.yaml	TPH2	Q8IWU9	NCBITaxon:9606	Homo sapiens	10	R-HSA-209828	Tryptophan is hydroxylated	yes	reactome/R-HSA-209828.md	Tryptophan is hydroxylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Traceable author statement (TAS, Reactome) localizing the tryptophan-hydroxylation reaction to the cytosol. TPH2 is a soluble tetrameric enzyme and the serotonin-synthesis reaction occurs in the neuronal cytoplasm/cytosol, consistent with the cytosolic nature of the aromatic amino acid hydroxylases. Accept as the primary subcellular location.
human	TPI1	genes/human/TPI1/TPI1-ai-review.yaml	TPI1	P60174	NCBITaxon:9606	Homo sapiens	17	R-HSA-70263	Gluconeogenesis	yes	reactome/R-HSA-70263.md	Gluconeogenesis	Homo sapiens	GO:0006094	gluconeogenesis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing TPI1 in the gluconeogenesis pathway. Consistent with the core gluconeogenic role.
human	TPI1	genes/human/TPI1/TPI1-ai-review.yaml	TPI1	P60174	NCBITaxon:9606	Homo sapiens	18	R-HSA-70171	Glycolysis	yes	reactome/R-HSA-70171.md	Glycolysis	Homo sapiens	GO:0061621	canonical glycolysis	TAS	involved_in	BP	false		ACCEPT	Reactome traceable assertion placing TPI1 in the (canonical) glycolysis pathway. Consistent with the core glycolytic role.
human	TPI1	genes/human/TPI1/TPI1-ai-review.yaml	TPI1	P60174	NCBITaxon:9606	Homo sapiens	21	R-HSA-70454	TPI1 dimer isomerizes DHAP to GA3P	yes	reactome/R-HSA-70454.md	TPI1 dimer isomerizes DHAP to GA3P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome localizes the TPI1-catalyzed reaction (DHAP to GA3P) to the cytosol. Correct core location.
human	TPI1	genes/human/TPI1/TPI1-ai-review.yaml	TPI1	P60174	NCBITaxon:9606	Homo sapiens	22	R-HSA-70481	TPI1 dimer isomerizes GA3P to DHAP	yes	reactome/R-HSA-70481.md	TPI1 dimer isomerizes GA3P to DHAP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome localizes the reverse TPI1 reaction (GA3P to DHAP) to the cytosol. Correct core location; duplicate of the preceding cytosol annotation.
human	TPK1	genes/human/TPK1/TPK1-ai-review.yaml	TPK1	Q9H3S4	NCBITaxon:9606	Homo sapiens	23	R-HSA-196761	2xTPK1:Mg2+ phosphorylates THMN	yes	reactome/R-HSA-196761.md	2xTPK1:Mg2+ phosphorylates THMN	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author statement placing TPK1 in the cytosol, where it phosphorylates thiamine. Consistent with all other localization evidence; accepted.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	24	R-HSA-390593	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-390593.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for muscle contraction. TPM1 is a cytosolic/ cytoskeletal protein that associates with actin filaments. Cytosol localization is valid for soluble tropomyosin before assembly.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	25	R-HSA-390595	Calcium Binds Troponin-C	yes	reactome/R-HSA-390595.md	Calcium Binds Troponin-C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization in muscle contraction pathway.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	26	R-HSA-390597	Release Of ADP From Myosin	yes	reactome/R-HSA-390597.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	27	R-HSA-390598	Myosin Binds ATP	yes	reactome/R-HSA-390598.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	28	R-HSA-445699	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-445699.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	29	R-HSA-445700	Myosin Binds ATP	yes	reactome/R-HSA-445700.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	30	R-HSA-445704	Calcium Binds Caldesmon	yes	reactome/R-HSA-445704.md	Calcium Binds Caldesmon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM1	genes/human/TPM1/TPM1-ai-review.yaml	TPM1	P09493	NCBITaxon:9606	Homo sapiens	31	R-HSA-445705	Release Of ADP From Myosin	yes	reactome/R-HSA-445705.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Duplicate Reactome pathway annotation for cytosol localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	24	R-HSA-9700179	Ligand-independent dimerization of ALK fusions	yes	reactome/R-HSA-9700179.md	Ligand-independent dimerization of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome row describes cytosolic signaling context for oncogenic ALK fusion proteins that can use TPM3 as an N-terminal fusion partner, not native TPM3 actin-filament localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	25	R-HSA-9700181	Autophosphorylation of ALK fusions	yes	reactome/R-HSA-9700181.md	Autophosphorylation of ALK fusions	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This Reactome row describes cytosolic signaling context for oncogenic ALK fusion proteins that can use TPM3 as an N-terminal fusion partner, not native TPM3 actin-filament localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	28	R-HSA-390593	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-390593.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	29	R-HSA-390595	Calcium Binds Troponin-C	yes	reactome/R-HSA-390595.md	Calcium Binds Troponin-C	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	30	R-HSA-390597	Release Of ADP From Myosin	yes	reactome/R-HSA-390597.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	31	R-HSA-390598	Myosin Binds ATP	yes	reactome/R-HSA-390598.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	32	R-HSA-445699	ATP Hydrolysis By Myosin	yes	reactome/R-HSA-445699.md	ATP Hydrolysis By Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	33	R-HSA-445700	Myosin Binds ATP	yes	reactome/R-HSA-445700.md	Myosin Binds ATP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	34	R-HSA-445704	Calcium Binds Caldesmon	yes	reactome/R-HSA-445704.md	Calcium Binds Caldesmon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TPM3	genes/human/TPM3/TPM3-ai-review.yaml	TPM3	P06753	NCBITaxon:9606	Homo sapiens	35	R-HSA-445705	Release Of ADP From Myosin	yes	reactome/R-HSA-445705.md	Release Of ADP From Myosin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	This cytosol annotation derives from a Reactome muscle contraction pathway step. It is compatible with TPM3-containing thin-filament complexes but is less informative than actin filament, muscle thin filament tropomyosin, or cytoskeleton localization.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	28	R-HSA-72103	Formation of pre-mRNPs	yes	reactome/R-HSA-72103.md	Formation of pre-mRNPs	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	29	R-HSA-9770119	Formation of the Spliceosomal E complex	yes	reactome/R-HSA-9770119.md	Formation of the Spliceosomal E complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	30	R-HSA-9770129	Formation of the Spliceosomal A complex	yes	reactome/R-HSA-9770129.md	Formation of the Spliceosomal A complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	31	R-HSA-9770131	Formation of the Spliceosomal B* complex	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	32	R-HSA-9770132	Formation of the Spliceosomal Pre-B complex	yes	reactome/R-HSA-9770132.md	Formation of the Spliceosomal Pre-B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	33	R-HSA-9770141	Formation of the Spliceosomal C* complex	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	34	R-HSA-9770142	Formation of the Spliceosomal B complex	yes	reactome/R-HSA-9770142.md	Formation of the Spliceosomal B complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	35	R-HSA-9770145	Formation of the Spliceosomal Bact complex	yes	reactome/R-HSA-9770145.md	Formation of the Spliceosomal Bact complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	36	R-HSA-9770236	Formation of the Spliceosomal P complex and exon ligation	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	37	R-HSA-9770847	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	38	R-HSA-9794542	Formation of the Spliceosomal C complex containing intron lariat	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	39	R-HSA-9970141	Core CPA complex binds capped pre-mRNA	yes	reactome/R-HSA-9970141.md	Core CPA complex binds capped pre-mRNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	40	R-HSA-9970179	Recruitment of other CPA components to pre-mRNA-bound CPA core	yes	reactome/R-HSA-9970179.md	Recruitment of other CPA components to pre-mRNA-bound CPA core	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	41	R-HSA-9970189	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS	yes	reactome/R-HSA-9970189.md	PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	42	R-HSA-9970190	PP1 dephosphorylates RNA Pol II	yes	reactome/R-HSA-9970190.md	PP1 dephosphorylates RNA Pol II	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	43	R-HSA-9970191	RBBP6 activates CPSF complex	yes	reactome/R-HSA-9970191.md	RBBP6 activates CPSF complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	44	R-HSA-9970193	CPSF3 cleaves pre-mRNA at distal 3'UTR PAS	yes	reactome/R-HSA-9970193.md	CPSF3 cleaves pre-mRNA at distal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	45	R-HSA-9970282	U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS	yes	reactome/R-HSA-9970282.md	U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	46	R-HSA-9970294	CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS	yes	reactome/R-HSA-9970294.md	CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	47	R-HSA-9970318	PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS	yes	reactome/R-HSA-9970318.md	PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	48	R-HSA-9970320	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS	yes	reactome/R-HSA-9970320.md	PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	49	R-HSA-9970428	CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)	yes	reactome/R-HSA-9970428.md	CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	50	R-HSA-9970429	CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)	yes	reactome/R-HSA-9970429.md	CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRA2B	genes/human/TRA2B/TRA2B-ai-review.yaml	TRA2B	P62995	NCBITaxon:9606	Homo sapiens	51	R-HSA-9970431	CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)	yes	reactome/R-HSA-9970431.md	CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear or nucleoplasmic localization is appropriate for a sequence-specific pre-mRNA splicing regulator.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	537	R-HSA-8862184	USP48 cleaves polyubiquitin	yes	reactome/R-HSA-8862184.md	USP48 cleaves polyubiquitin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		UNDECIDED	The specific nucleoplasm assertion from Reactome:R-HSA-8862184 requires tracing the relevant experiment or inference. The established receptor-adaptor mechanism neither proves nor refutes this additional role.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	545	R-HSA-139952	Caspase-8 processing in the DISC	yes	reactome/R-HSA-139952.md	Caspase-8 processing in the DISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	546	R-HSA-140978	TRADD:TRAF2:RIP1 binds FADD	yes	reactome/R-HSA-140978.md	TRADD:TRAF2:RIP1 binds FADD	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	547	R-HSA-141159	TNF-mediated dimerization of procaspase-8	yes	reactome/R-HSA-141159.md	TNF-mediated dimerization of procaspase-8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	548	R-HSA-3371360	FLIP(L) and procaspase-8 form heterodimer in TNF signaling	yes	reactome/R-HSA-3371360.md	FLIP(L) and procaspase-8 form heterodimer in TNF signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	549	R-HSA-3465429	FLIP(S) and procaspase-8 form heterodimer	yes	reactome/R-HSA-3465429.md	FLIP(S) and procaspase-8 form heterodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	550	R-HSA-3465448	Caspase-8 and FLIP(L) processing at DISC	yes	reactome/R-HSA-3465448.md	Caspase-8 and FLIP(L) processing at DISC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	551	R-HSA-5357757	BIRC(cIAP1/2) ubiquitinates RIPK1	yes	reactome/R-HSA-5357757.md	BIRC(cIAP1/2) ubiquitinates RIPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	552	R-HSA-5357776	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG	yes	reactome/R-HSA-5357776.md	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	553	R-HSA-5357780	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)	yes	reactome/R-HSA-5357780.md	TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	554	R-HSA-5357828	RIPK1 is cleaved by CASP8	yes	reactome/R-HSA-5357828.md	RIPK1 is cleaved by CASP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	555	R-HSA-5357845	K63polyUb-RIPK1 is deubiquitinated	yes	reactome/R-HSA-5357845.md	K63polyUb-RIPK1 is deubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	556	R-HSA-5357860	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex	yes	reactome/R-HSA-5357860.md	TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	557	R-HSA-5357904	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC	yes	reactome/R-HSA-5357904.md	TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	558	R-HSA-5357928	CLIP3 and CYLD bind TNF signaling complex	yes	reactome/R-HSA-5357928.md	CLIP3 and CYLD bind TNF signaling complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	559	R-HSA-5634221	TRAF1 binds TRAF2 within TNFR1 signaling complex	yes	reactome/R-HSA-5634221.md	TRAF1 binds TRAF2 within TNFR1 signaling complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	560	R-HSA-5668414	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK	yes	reactome/R-HSA-5668414.md	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	561	R-HSA-5668417	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer	yes	reactome/R-HSA-5668417.md	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	562	R-HSA-5668454	K63polyUb-cIAP1,2 ubiquitinates TRAF3	yes	reactome/R-HSA-5668454.md	K63polyUb-cIAP1,2 ubiquitinates TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	563	R-HSA-5668481	Protesomal degradation of K48polyUb-TRAF3	yes	reactome/R-HSA-5668481.md	Protesomal degradation of K48polyUb-TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	564	R-HSA-5668534	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK	yes	reactome/R-HSA-5668534.md	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	565	R-HSA-5668543	TRAF3:NIK binds TRAF2:cIAP1/2	yes	reactome/R-HSA-5668543.md	TRAF3:NIK binds TRAF2:cIAP1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	566	R-HSA-5675456	FLIP(L) and procaspase-8 form heterodimer	yes	reactome/R-HSA-5675456.md	FLIP(L) and procaspase-8 form heterodimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	567	R-HSA-5676593	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR	yes	reactome/R-HSA-5676593.md	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	568	R-HSA-5676595	TRAFs bind RANK:RANKL	yes	reactome/R-HSA-5676595.md	TRAFs bind RANK:RANKL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	569	R-HSA-5676596	TRAF3 binds BAFFR:BAFF	yes	reactome/R-HSA-5676596.md	TRAF3 binds BAFFR:BAFF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	570	R-HSA-5676597	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40	yes	reactome/R-HSA-5676597.md	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	571	R-HSA-5676598	TRAF2:cIAP1/2 complex binds FN14:TWEAK	yes	reactome/R-HSA-5676598.md	TRAF2:cIAP1/2 complex binds FN14:TWEAK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	572	R-HSA-5693055	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	yes	reactome/R-HSA-5693055.md	TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	573	R-HSA-5693108	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	yes	reactome/R-HSA-5693108.md	TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	574	R-HSA-5696627	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG	yes	reactome/R-HSA-5696627.md	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	575	R-HSA-75240	TRADD:TRAF2:RIP1:FADD binds pro-caspase 8	yes	reactome/R-HSA-75240.md	TRADD:TRAF2:RIP1:FADD binds pro-caspase 8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	576	R-HSA-83582	TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1	yes	reactome/R-HSA-83582.md	TRADD:TRAF2:RIP1 dissociates from TNF-α:TNFR1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	577	R-HSA-83656	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1	yes	reactome/R-HSA-83656.md	TNF:TNFR1 binds TRADD, TRAF2 and RIPK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	578	R-HSA-8869456	USP4 deubiquitinate TRAF2,TRAF6	yes	reactome/R-HSA-8869456.md	USP4 deubiquitinate TRAF2,TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	579	R-HSA-918230	Recruitment of TRAF6/TRAF2 to MAVS	yes	reactome/R-HSA-918230.md	Recruitment of TRAF6/TRAF2 to MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	580	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	581	R-HSA-933527	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	yes	reactome/R-HSA-933527.md	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	582	R-HSA-933530	Activation of IKK by MEKK1	yes	reactome/R-HSA-933530.md	Activation of IKK by MEKK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	583	R-HSA-933537	Recruitment of TANK to TRAF6	yes	reactome/R-HSA-933537.md	Recruitment of TANK to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	584	R-HSA-933538	Recruitment of IRF7 to TRAF6	yes	reactome/R-HSA-933538.md	Recruitment of IRF7 to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	585	R-HSA-9693929	RIPK1 variant is not cleaved by CASP8	yes	reactome/R-HSA-9693929.md	RIPK1 variant is not cleaved by CASP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	586	R-HSA-9697747	Caspase-8 and FLIP(L) processing at TNFR signaling complex	yes	reactome/R-HSA-9697747.md	Caspase-8 and FLIP(L) processing at TNFR signaling complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	587	R-HSA-9697750	RIPK1 is cleaved by CASP8:FLIP(L)	yes	reactome/R-HSA-9697750.md	RIPK1 is cleaved by CASP8:FLIP(L)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	588	R-HSA-9705145	TBK1, IKBKE form homodimers	yes	reactome/R-HSA-9705145.md	TBK1, IKBKE form homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	589	R-HSA-9705323	Phosphorylation of TBK1/IKBKE	yes	reactome/R-HSA-9705323.md	Phosphorylation of TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	590	R-HSA-9750946	TRAF2,6 ubiquitinates NLRC5	yes	reactome/R-HSA-9750946.md	TRAF2,6 ubiquitinates NLRC5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	591	R-HSA-9793679	LUBAC ubiquitinates RIPK1 at K627	yes	reactome/R-HSA-9793679.md	LUBAC ubiquitinates RIPK1 at K627	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	592	R-HSA-9793680	OPTN binds polyUb-RIPK1 within the TNFR1 complex	yes	reactome/R-HSA-9793680.md	OPTN binds polyUb-RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	593	R-HSA-9796342	MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2	yes	reactome/R-HSA-9796342.md	MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	594	R-HSA-9796346	MIB2 ubiquitinates RIPK1 at K377, K604, K634	yes	reactome/R-HSA-9796346.md	MIB2 ubiquitinates RIPK1 at K377, K604, K634	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	595	R-HSA-9796379	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex	yes	reactome/R-HSA-9796379.md	CYLD:SPATA2:LUBAC binds TNFR1 signaling complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	596	R-HSA-9815501	MAPKAPK2 phosphorylates RIPK1 at S320	yes	reactome/R-HSA-9815501.md	MAPKAPK2 phosphorylates RIPK1 at S320	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	597	R-HSA-9817362	SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex	yes	reactome/R-HSA-9817362.md	SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	598	R-HSA-9817397	TBK1, IKBKE phosphorylate RIPK1 at T189	yes	reactome/R-HSA-9817397.md	TBK1, IKBKE phosphorylate RIPK1 at T189	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	599	R-HSA-9817400	CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex	yes	reactome/R-HSA-9817400.md	CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	600	R-HSA-9817411	TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex	yes	reactome/R-HSA-9817411.md	TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	601	R-HSA-9818789	CHUK, IKBKB phosphorylate RIPK1 at S25	yes	reactome/R-HSA-9818789.md	CHUK, IKBKB phosphorylate RIPK1 at S25	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	602	R-HSA-9818975	CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex	yes	reactome/R-HSA-9818975.md	CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	603	R-HSA-9819106	ULK1 phosphorylates RIPK1 at S357	yes	reactome/R-HSA-9819106.md	ULK1 phosphorylates RIPK1 at S357	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF2	genes/human/TRAF2/TRAF2-ai-review.yaml	TRAF2	Q12933	NCBITaxon:9606	Homo sapiens	604	R-HSA-9824874	OPTN recruits CYLD to the TNFR1 complex	yes	reactome/R-HSA-9824874.md	OPTN recruits CYLD to the TNFR1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF2 is a cytoplasmic signaling adaptor recruited to the intracellular side of ligand-engaged receptors. Cytosolic and receptor-associated membrane pools are compatible, and no integral-membrane or extracellular localization is implied.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	55	R-HSA-936964	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	yes	reactome/R-HSA-936964.md	Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Homo sapiens	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF3 is the TRIF-proximal component that brings TBK1 into the TIR signalling complex, making it essential for the TRIF-dependent interferon branch.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	69	R-HSA-2213017	Auto-ubiquitination of TRAF3	yes	reactome/R-HSA-2213017.md	Auto-ubiquitination of TRAF3	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		MODIFY	Parent term for ubiquitin transfer; TRAF3's activity is specifically that of a RING-type E3 ubiquitin ligase.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	70	R-HSA-9013974	Auto-ubiquitination of TRAF3 within activated TLR3 complex	yes	reactome/R-HSA-9013974.md	Auto-ubiquitination of TRAF3 within activated TLR3 complex	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		MODIFY	Parent term for ubiquitin transfer; TRAF3's activity is specifically that of a RING-type E3 ubiquitin ligase.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	73	R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	yes	reactome/R-HSA-9013973.md	TICAM1-dependent activation of IRF3/IRF7	Homo sapiens	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF3 is the TRIF-proximal component that brings TBK1 into the TIR signalling complex, making it essential for the TRIF-dependent interferon branch.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	81	R-HSA-166245	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	yes	reactome/R-HSA-166245.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	82	R-HSA-166271	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	yes	reactome/R-HSA-166271.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	83	R-HSA-2213017	Auto-ubiquitination of TRAF3	yes	reactome/R-HSA-2213017.md	Auto-ubiquitination of TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	84	R-HSA-5362486	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4	yes	reactome/R-HSA-5362486.md	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	85	R-HSA-5362500	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-5362500.md	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	86	R-HSA-9013974	Auto-ubiquitination of TRAF3 within activated TLR3 complex	yes	reactome/R-HSA-9013974.md	Auto-ubiquitination of TRAF3 within activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	87	R-HSA-9013978	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	yes	reactome/R-HSA-9013978.md	Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	88	R-HSA-9013979	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	yes	reactome/R-HSA-9013979.md	IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	89	R-HSA-9013985	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3	yes	reactome/R-HSA-9013985.md	TANK binds K63-poly-Ub-TRAF3:TICAM1:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	90	R-HSA-9013990	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA	yes	reactome/R-HSA-9013990.md	TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	91	R-HSA-918225	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	yes	reactome/R-HSA-918225.md	TBK1/IKK epsilon complex interacts with MAVS bound TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	92	R-HSA-918227	Recruitment of TRAF3 to MAVS	yes	reactome/R-HSA-918227.md	Recruitment of TRAF3 to MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	93	R-HSA-918229	Phosphorylation and release of IRF3/IRF7	yes	reactome/R-HSA-918229.md	Phosphorylation and release of IRF3/IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	94	R-HSA-918232	Recruitment of IRF3,IRF7	yes	reactome/R-HSA-918232.md	Recruitment of IRF3,IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	95	R-HSA-936381	OTUD5 deubiquitinates TRAF3	yes	reactome/R-HSA-936381.md	OTUD5 deubiquitinates TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	96	R-HSA-9685162	SARS-CoV-1 M protein interacts with TRAF3	yes	reactome/R-HSA-9685162.md	SARS-CoV-1 M protein interacts with TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	97	R-HSA-9705137	TBK1 or IKBKE forms homodimers	yes	reactome/R-HSA-9705137.md	TBK1 or IKBKE forms homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	98	R-HSA-9705320	TBK1, IKBKE are autophosphorylated at Ser172	yes	reactome/R-HSA-9705320.md	TBK1, IKBKE are autophosphorylated at Ser172	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	99	R-HSA-9823904	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823904.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	100	R-HSA-9823906	TBK1 is phosphorylated within the activated TLR4 complex	yes	reactome/R-HSA-9823906.md	TBK1 is phosphorylated within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	101	R-HSA-9823910	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823910.md	Recruitment of TBK1 to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	102	R-HSA-9823932	Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	yes	reactome/R-HSA-9823932.md	Recruitment of IKKε (IKBKE) to K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	103	R-HSA-9823934	OPTN binds TBK1 within the activated TLR4 complex	yes	reactome/R-HSA-9823934.md	OPTN binds TBK1 within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	104	R-HSA-9823939	IKKε (IKBKE) is ubiquitinated within the activated TLR4	yes	reactome/R-HSA-9823939.md	IKKε (IKBKE) is ubiquitinated within the activated TLR4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	105	R-HSA-9824882	IKKε (IKBKE) is phosphorylated within the activated TLR4 complex	yes	reactome/R-HSA-9824882.md	IKKε (IKBKE) is phosphorylated within the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	106	R-HSA-9828196	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828196.md	TBK1 binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	107	R-HSA-9828200	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828200.md	TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	108	R-HSA-9828204	IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	yes	reactome/R-HSA-9828204.md	IKKε (IKBKE) binds K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	109	R-HSA-9828205	TBK1 is phosphorylated within the activated TLR3 complex	yes	reactome/R-HSA-9828205.md	TBK1 is phosphorylated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	110	R-HSA-9828209	OPTN binds TBK1 within the activated TLR3 complex	yes	reactome/R-HSA-9828209.md	OPTN binds TBK1 within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	111	R-HSA-9830706	IKKε (IKBKE) is phosphorylated within the activated TLR3 complex	yes	reactome/R-HSA-9830706.md	IKKε (IKBKE) is phosphorylated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	112	R-HSA-9830710	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex	yes	reactome/R-HSA-9830710.md	IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	114	R-HSA-5602624	Defective TRAF3 does not transmit the signal	yes	reactome/R-HSA-5602624.md	Defective TRAF3 does not transmit the signal	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	116	R-HSA-5668454	K63polyUb-cIAP1,2 ubiquitinates TRAF3	yes	reactome/R-HSA-5668454.md	K63polyUb-cIAP1,2 ubiquitinates TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	117	R-HSA-5668481	Protesomal degradation of K48polyUb-TRAF3	yes	reactome/R-HSA-5668481.md	Protesomal degradation of K48polyUb-TRAF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	118	R-HSA-936475	Negative regulation of DDX58/IFIH1 signaling by RNF216	yes	reactome/R-HSA-936475.md	Negative regulation of DDX58/IFIH1 signaling by RNF216	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	132	R-HSA-2201338	TRAF3 binds TICAM1:activated TLR4 complex	yes	reactome/R-HSA-2201338.md	TRAF3 binds TICAM1:activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	133	R-HSA-5668414	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK	yes	reactome/R-HSA-5668414.md	TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	134	R-HSA-5668417	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer	yes	reactome/R-HSA-5668417.md	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	135	R-HSA-5668534	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK	yes	reactome/R-HSA-5668534.md	cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	136	R-HSA-5668543	TRAF3:NIK binds TRAF2:cIAP1/2	yes	reactome/R-HSA-5668543.md	TRAF3:NIK binds TRAF2:cIAP1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	137	R-HSA-5676593	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR	yes	reactome/R-HSA-5676593.md	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds LTBR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	138	R-HSA-5676595	TRAFs bind RANK:RANKL	yes	reactome/R-HSA-5676595.md	TRAFs bind RANK:RANKL	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	139	R-HSA-5676596	TRAF3 binds BAFFR:BAFF	yes	reactome/R-HSA-5676596.md	TRAF3 binds BAFFR:BAFF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	140	R-HSA-5676597	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40	yes	reactome/R-HSA-5676597.md	TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	141	R-HSA-5676598	TRAF2:cIAP1/2 complex binds FN14:TWEAK	yes	reactome/R-HSA-5676598.md	TRAF2:cIAP1/2 complex binds FN14:TWEAK	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	142	R-HSA-5690843	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	yes	reactome/R-HSA-5690843.md	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF3	genes/human/TRAF3/TRAF3-ai-review.yaml	TRAF3	Q13114	NCBITaxon:9606	Homo sapiens	143	R-HSA-9013992	TRAF3 binds to TRIF:activated TLR3 complex	yes	reactome/R-HSA-9013992.md	TRAF3 binds to TRIF:activated TLR3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation, asserted by Reactome across the TLR, RLR, CD40 and non-canonical NF-kappaB reactions in which TRAF3 participates.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	4	R-HSA-202453	TRAF6 pathway	yes	reactome/R-HSA-202453.md	Auto-ubiquitination of TRAF6	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation based on traceable author statement.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	54	R-HSA-202534	Ubiquitination of NEMO by TRAF6	yes	reactome/R-HSA-202534.md	Ubiquitination of NEMO by TRAF6	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	55	R-HSA-2730904	Auto-ubiquitination of TRAF6	yes	reactome/R-HSA-2730904.md	Auto-ubiquitination of TRAF6	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	56	R-HSA-446877	TRAF6 is K63 poly-ubiquitinated	yes	reactome/R-HSA-446877.md	TRAF6 is K63 poly-ubiquitinated	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	57	R-HSA-450358	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	yes	reactome/R-HSA-450358.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	58	R-HSA-936942	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2	yes	reactome/R-HSA-936942.md	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	59	R-HSA-936986	Activated TRAF6 synthesizes unanchored polyubiquitin chains	yes	reactome/R-HSA-936986.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	60	R-HSA-9645394	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	yes	reactome/R-HSA-9645394.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	61	R-HSA-9645414	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	yes	reactome/R-HSA-9645414.md	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	62	R-HSA-975147	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane	yes	reactome/R-HSA-975147.md	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Pathway database annotation for TRAF6 E3 ligase activity.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	187	R-HSA-9020702	Interleukin-1 signaling	yes	reactome/R-HSA-9020702.md	Interleukin-1 signaling	Homo sapiens	GO:0070498	interleukin-1-mediated signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 is essential for IL-1 receptor signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	188	R-HSA-5621481	C-type lectin receptors (CLRs)	yes	reactome/R-HSA-5621481.md	C-type lectin receptors (CLRs)	Homo sapiens	GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 stimulates immune responses.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	189	R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	yes	reactome/R-HSA-9645460.md	Alpha-protein kinase 1 signaling pathway	Homo sapiens	GO:0002753	cytoplasmic pattern recognition receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 mediates signaling from cytosolic pattern recognition receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	190	R-HSA-166058	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	yes	reactome/R-HSA-166058.md	MyD88:MAL(TIRAP) cascade initiated on plasma membrane	Homo sapiens	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 mediates MyD88-dependent TLR signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	191	R-HSA-975871	MyD88 cascade initiated on plasma membrane	yes	reactome/R-HSA-975871.md	MyD88 cascade initiated on plasma membrane	Homo sapiens	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 mediates MyD88-dependent TLR signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	192	R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	yes	reactome/R-HSA-937072.md	TRAF6-mediated induction of TAK1 complex within TLR4 complex	Homo sapiens	GO:0007249	canonical NF-kappaB signal transduction	TAS	involved_in	BP	false		ACCEPT	TRAF6 is essential for IKK/NF-κB signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	193	R-HSA-168164	Toll Like Receptor 3 (TLR3) Cascade	yes	reactome/R-HSA-168164.md	Toll Like Receptor 3 (TLR3) Cascade	Homo sapiens	GO:0034138	toll-like receptor 3 signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Minor or context-specific TRAF6 function.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	194	R-HSA-937061	TRIF (TICAM1)-mediated TLR4 signaling	yes	reactome/R-HSA-937061.md	TRIF (TICAM1)-mediated TLR4 signaling	Homo sapiens	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Minor or context-specific TRAF6 function.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	195	R-HSA-2454202	Fc epsilon receptor (FCERI) signaling	yes	reactome/R-HSA-2454202.md	Fc epsilon receptor (FCERI) signaling	Homo sapiens	GO:0038095	Fc-epsilon receptor signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	TRAF6 mediates Fc receptor signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	196	R-HSA-202403	TCR signaling	yes	reactome/R-HSA-202403.md	TCR signaling	Homo sapiens	GO:0050852	T cell receptor signaling pathway	TAS	involved_in	BP	false		ACCEPT	TRAF6 has roles in T cell signaling.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	252	R-HSA-168184	Activated TAK1 mediates phosphorylation of the IKK Complex	yes	reactome/R-HSA-168184.md	Activated TAK1 mediates phosphorylation of the IKK Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	253	R-HSA-202453	TRAF6 pathway	yes	reactome/R-HSA-202453.md	Auto-ubiquitination of TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	254	R-HSA-202500	Activation of IKK complex	yes	reactome/R-HSA-202500.md	Activation of IKK complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	255	R-HSA-202510	Activation of TAK1-TAB2 complex	yes	reactome/R-HSA-202510.md	Activation of TAK1-TAB2 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	256	R-HSA-202534	Ubiquitination of NEMO by TRAF6	yes	reactome/R-HSA-202534.md	Ubiquitination of NEMO by TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	257	R-HSA-209566	TRAF6 is auto-ubiquitinated	yes	reactome/R-HSA-209566.md	TRAF6 is auto-ubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	258	R-HSA-2730861	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6	yes	reactome/R-HSA-2730861.md	Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	259	R-HSA-2730876	Phosphorylation of IKK-beta by TAK1	yes	reactome/R-HSA-2730876.md	Phosphorylation of IKK-beta by TAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	260	R-HSA-2730900	Activation of TAK1 complex bound to pUb-TRAF6	yes	reactome/R-HSA-2730900.md	Activation of TAK1 complex bound to pUb-TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	261	R-HSA-2730904	Auto-ubiquitination of TRAF6	yes	reactome/R-HSA-2730904.md	Auto-ubiquitination of TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	262	R-HSA-446870	Polyubiquitinated TRAF6 binds the TAK1 complex	yes	reactome/R-HSA-446870.md	Polyubiquitinated TRAF6 binds the TAK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	263	R-HSA-446877	TRAF6 is K63 poly-ubiquitinated	yes	reactome/R-HSA-446877.md	TRAF6 is K63 poly-ubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	264	R-HSA-450187	TAK1 is activated within the TAK1 complex	yes	reactome/R-HSA-450187.md	TAK1 is activated within the TAK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	265	R-HSA-450337	Activated TAK1 phosphorylates MKK4/MKK7	yes	reactome/R-HSA-450337.md	Activated TAK1 phosphorylates MKK4/MKK7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	266	R-HSA-450346	activated human TAK1 phosphorylates MKK3/MKK6	yes	reactome/R-HSA-450346.md	activated human TAK1 phosphorylates MKK3/MKK6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	267	R-HSA-450358	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	yes	reactome/R-HSA-450358.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	268	R-HSA-5607732	K63polyUb-TAK1 autophosphorylates	yes	reactome/R-HSA-5607732.md	K63polyUb-TAK1 autophosphorylates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	269	R-HSA-5607742	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta	yes	reactome/R-HSA-5607742.md	K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	270	R-HSA-5607756	TRAF6 oligomer autoubiquitinates	yes	reactome/R-HSA-5607756.md	TRAF6 oligomer autoubiquitinates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	271	R-HSA-5607757	K63polyUb-TRAF6 ubiquitinates TAK1	yes	reactome/R-HSA-5607757.md	K63polyUb-TRAF6 ubiquitinates TAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	272	R-HSA-5607759	TRIKA2 binds K63polyUb-TRAF6 oligomer	yes	reactome/R-HSA-5607759.md	TRIKA2 binds K63polyUb-TRAF6 oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	273	R-HSA-5696627	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG	yes	reactome/R-HSA-5696627.md	CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	274	R-HSA-847070	Phosphorylated TAK1 dissociates from the TLR3 receptor complex	yes	reactome/R-HSA-847070.md	Phosphorylated TAK1 dissociates from the TLR3 receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	275	R-HSA-8869506	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	yes	reactome/R-HSA-8869506.md	TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	276	R-HSA-8948018	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1	yes	reactome/R-HSA-8948018.md	UBE2N:UBE2V1 dissociates from hp-IRAK1:3xK63-polyUb-TRAF6:3xUBE2N:UBE2V1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	277	R-HSA-936947	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex	yes	reactome/R-HSA-936947.md	Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	278	R-HSA-936951	Activation of TAK1 complex bound to activated TLR4 complex	yes	reactome/R-HSA-936951.md	Activation of TAK1 complex bound to activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	279	R-HSA-936952	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex	yes	reactome/R-HSA-936952.md	Auto ubiquitination of TRAF6 bound to the activated TLR4 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	280	R-HSA-937075	Phosphorylated TAK1 leaves activated TLR receptor complex	yes	reactome/R-HSA-937075.md	Phosphorylated TAK1 leaves activated TLR receptor complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	281	R-HSA-9645394	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	yes	reactome/R-HSA-9645394.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	282	R-HSA-9645406	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)	yes	reactome/R-HSA-9645406.md	ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	283	R-HSA-9645414	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	yes	reactome/R-HSA-9645414.md	Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	284	R-HSA-9645442	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex	yes	reactome/R-HSA-9645442.md	Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	285	R-HSA-9758604	Ubiquitination of IKBKG by TRAF6	yes	reactome/R-HSA-9758604.md	Ubiquitination of IKBKG by TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	286	R-HSA-5690870	OTUD7B,TNFAIP3 deubiquitinate TRAF6	yes	reactome/R-HSA-5690870.md	OTUD7B,TNFAIP3 deubiquitinate TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	287	R-HSA-8869456	USP4 deubiquitinate TRAF2,TRAF6	yes	reactome/R-HSA-8869456.md	USP4 deubiquitinate TRAF2,TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	289	R-HSA-936942	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2	yes	reactome/R-HSA-936942.md	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	290	R-HSA-936960	Activated TRAF6:p-IRAK2 interacts with TAK1 complex	yes	reactome/R-HSA-936960.md	Activated TRAF6:p-IRAK2 interacts with TAK1 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	291	R-HSA-936986	Activated TRAF6 synthesizes unanchored polyubiquitin chains	yes	reactome/R-HSA-936986.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	292	R-HSA-936991	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3	yes	reactome/R-HSA-936991.md	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	293	R-HSA-9758604	Ubiquitination of IKBKG by TRAF6	yes	reactome/R-HSA-9758604.md	Ubiquitination of IKBKG by TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	294	R-HSA-177690	Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex	yes	reactome/R-HSA-177690.md	Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	295	R-HSA-177692	Activation of recruited TAK1 within the activated TLR3 complex	yes	reactome/R-HSA-177692.md	Activation of recruited TAK1 within the activated TLR3 complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	296	R-HSA-450259	Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex	yes	reactome/R-HSA-450259.md	Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	297	R-HSA-450358	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	yes	reactome/R-HSA-450358.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	298	R-HSA-847070	Phosphorylated TAK1 dissociates from the TLR3 receptor complex	yes	reactome/R-HSA-847070.md	Phosphorylated TAK1 dissociates from the TLR3 receptor complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	299	R-HSA-9628444	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation	yes	reactome/R-HSA-9628444.md	Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	300	R-HSA-9685219	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)	yes	reactome/R-HSA-9685219.md	SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	301	R-HSA-975097	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation	yes	reactome/R-HSA-975097.md	Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	302	R-HSA-975103	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation	yes	reactome/R-HSA-975103.md	Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	303	R-HSA-975147	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane	yes	reactome/R-HSA-975147.md	Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	314	R-HSA-166362	Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	yes	reactome/R-HSA-166362.md	Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	315	R-HSA-166363	TRAF6 binds to hp- IRAK1	yes	reactome/R-HSA-166363.md	TRAF6 binds to hp- IRAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	316	R-HSA-2262775	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	yes	reactome/R-HSA-2262775.md	Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	317	R-HSA-2262777	TRAF6 binds to p-IRAK2	yes	reactome/R-HSA-2262777.md	TRAF6 binds to p-IRAK2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	318	R-HSA-936963	IRAK2 induces TRAF6 oligomerization	yes	reactome/R-HSA-936963.md	IRAK2 induces TRAF6 oligomerization	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	319	R-HSA-937034	IRAK1 phosphorylates Pellino	yes	reactome/R-HSA-937034.md	IRAK1 phosphorylates Pellino	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	320	R-HSA-937044	Pellino binds hp-IRAK1:TRAF6	yes	reactome/R-HSA-937044.md	Pellino binds hp-IRAK1:TRAF6	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	321	R-HSA-937050	Pellino ubiquitinates hp-IRAK1	yes	reactome/R-HSA-937050.md	Pellino ubiquitinates hp-IRAK1	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	322	R-HSA-975857	TRAF6 binds to hp- IRAK1 or p-IRAK2	yes	reactome/R-HSA-975857.md	TRAF6 binds to hp- IRAK1 or p-IRAK2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	323	R-HSA-975879	Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex	yes	reactome/R-HSA-975879.md	Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to plasma membrane when recruited by activated receptors.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	337	R-HSA-166363	TRAF6 binds to hp- IRAK1	yes	reactome/R-HSA-166363.md	TRAF6 binds to hp- IRAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	338	R-HSA-166869	TRAF6 binds MEKK1	yes	reactome/R-HSA-166869.md	TRAF6 binds MEKK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	339	R-HSA-177694	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6	yes	reactome/R-HSA-177694.md	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	340	R-HSA-193641	IKK-beta is recruited	yes	reactome/R-HSA-193641.md	IKK-beta is recruited	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	341	R-HSA-193665	MYD88 dissociates	yes	reactome/R-HSA-193665.md	MYD88 dissociates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	342	R-HSA-193669	TRAF6 binds to p75NTR:NRIF	yes	reactome/R-HSA-193669.md	TRAF6 binds to p75NTR:NRIF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	343	R-HSA-193684	p62 recruits an atypical PKC	yes	reactome/R-HSA-193684.md	p62 recruits an atypical PKC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	344	R-HSA-193694	p62 is recruited and forms a complex with TRAF6	yes	reactome/R-HSA-193694.md	p62 is recruited and forms a complex with TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	345	R-HSA-193695	IRAK interacts with TRAF6	yes	reactome/R-HSA-193695.md	IRAK interacts with TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	346	R-HSA-193700	p75NTR ICD signals to NF-kB	yes	reactome/R-HSA-193700.md	p75NTR ICD signals to NF-kB	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	347	R-HSA-193703	IKKbeta is activated	yes	reactome/R-HSA-193703.md	IKKbeta is activated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	348	R-HSA-193705	IKKbeta phosphorylates IkB causing NF-kB to dissociate	yes	reactome/R-HSA-193705.md	IKKbeta phosphorylates IkB causing NF-kB to dissociate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	349	R-HSA-202472	Translocation of TRAF6 to CBM complex	yes	reactome/R-HSA-202472.md	Translocation of TRAF6 to CBM complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	350	R-HSA-205112	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	yes	reactome/R-HSA-205112.md	gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	351	R-HSA-205118	TRAF6 polyubiquitinates NRIF	yes	reactome/R-HSA-205118.md	TRAF6 polyubiquitinates NRIF	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	352	R-HSA-2262777	TRAF6 binds to p-IRAK2	yes	reactome/R-HSA-2262777.md	TRAF6 binds to p-IRAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	353	R-HSA-2730864	Recruitment of TRAF6 to CBM complex by binding to MALT1	yes	reactome/R-HSA-2730864.md	Recruitment of TRAF6 to CBM complex by binding to MALT1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	354	R-HSA-2730903	Oligomerization of TRAF6	yes	reactome/R-HSA-2730903.md	Oligomerization of TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	355	R-HSA-446862	Hyperphosphorylated IRAK1 associates with TRAF6	yes	reactome/R-HSA-446862.md	Hyperphosphorylated IRAK1 associates with TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	356	R-HSA-446894	TRAF6 binding leads to IRAK1:TRAF6 release	yes	reactome/R-HSA-446894.md	TRAF6 binding leads to IRAK1:TRAF6 release	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	357	R-HSA-450173	IRAK1 induces oligomerisation of TRAF6	yes	reactome/R-HSA-450173.md	IRAK1 induces oligomerisation of TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	358	R-HSA-507719	p62:MEKK3 binds to TRAF6	yes	reactome/R-HSA-507719.md	p62:MEKK3 binds to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	359	R-HSA-5607747	TRAF6 binds MALT1 oligomers	yes	reactome/R-HSA-5607747.md	TRAF6 binds MALT1 oligomers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	360	R-HSA-5607751	TRAF6 oligomerizes	yes	reactome/R-HSA-5607751.md	TRAF6 oligomerizes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	361	R-HSA-5690843	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	yes	reactome/R-HSA-5690843.md	OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	362	R-HSA-741386	RIP2 induces K63-linked ubiquitination of NEMO	yes	reactome/R-HSA-741386.md	RIP2 induces K63-linked ubiquitination of NEMO	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	363	R-HSA-8948015	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb	yes	reactome/R-HSA-8948015.md	hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	364	R-HSA-918230	Recruitment of TRAF6/TRAF2 to MAVS	yes	reactome/R-HSA-918230.md	Recruitment of TRAF6/TRAF2 to MAVS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	365	R-HSA-933525	Phosphorylation and release of IRF7	yes	reactome/R-HSA-933525.md	Phosphorylation and release of IRF7	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	366	R-HSA-933527	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	yes	reactome/R-HSA-933527.md	Recruitment of TBK1/IKK epsilon complex to TANK:TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	367	R-HSA-933530	Activation of IKK by MEKK1	yes	reactome/R-HSA-933530.md	Activation of IKK by MEKK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	368	R-HSA-933537	Recruitment of TANK to TRAF6	yes	reactome/R-HSA-933537.md	Recruitment of TANK to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	369	R-HSA-933538	Recruitment of IRF7 to TRAF6	yes	reactome/R-HSA-933538.md	Recruitment of IRF7 to TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	370	R-HSA-936963	IRAK2 induces TRAF6 oligomerization	yes	reactome/R-HSA-936963.md	IRAK2 induces TRAF6 oligomerization	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	371	R-HSA-936985	Activated TLR4:TICAM1 recruits TRAF6	yes	reactome/R-HSA-936985.md	Activated TLR4:TICAM1 recruits TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	372	R-HSA-937032	NEMO subunit of IKK complex binds to activated IRAK1	yes	reactome/R-HSA-937032.md	NEMO subunit of IKK complex binds to activated IRAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	373	R-HSA-937050	Pellino ubiquitinates hp-IRAK1	yes	reactome/R-HSA-937050.md	Pellino ubiquitinates hp-IRAK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	374	R-HSA-9645501	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex	yes	reactome/R-HSA-9645501.md	TRAF6 oligomerizes within the ALPK1:ADP-heptose:TIFA oligomer complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	375	R-HSA-9645520	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6	yes	reactome/R-HSA-9645520.md	ALPK1:ADP-heptose:TIFA oligomer recruits TRAF6	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	376	R-HSA-9705145	TBK1, IKBKE form homodimers	yes	reactome/R-HSA-9705145.md	TBK1, IKBKE form homodimers	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	377	R-HSA-9705323	Phosphorylation of TBK1/IKBKE	yes	reactome/R-HSA-9705323.md	Phosphorylation of TBK1/IKBKE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	378	R-HSA-9750946	TRAF2,6 ubiquitinates NLRC5	yes	reactome/R-HSA-9750946.md	TRAF2,6 ubiquitinates NLRC5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	379	R-HSA-975111	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9	yes	reactome/R-HSA-975111.md	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	380	R-HSA-975185	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments	yes	reactome/R-HSA-975185.md	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	381	R-HSA-975857	TRAF6 binds to hp- IRAK1 or p-IRAK2	yes	reactome/R-HSA-975857.md	TRAF6 binds to hp- IRAK1 or p-IRAK2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAF6 localizes to the cytosol.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	383	R-HSA-177694	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6	yes	reactome/R-HSA-177694.md	Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	384	R-HSA-975100	Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex	yes	reactome/R-HSA-975100.md	Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	385	R-HSA-975106	Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation	yes	reactome/R-HSA-975106.md	Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	386	R-HSA-975111	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9	yes	reactome/R-HSA-975111.md	TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	387	R-HSA-975118	TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex	yes	reactome/R-HSA-975118.md	TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	388	R-HSA-975119	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9	yes	reactome/R-HSA-975119.md	NEMO subunit of IKK complex binds to activated IRAK1 upon stimulation of TLR7/8 or 9	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	389	R-HSA-975122	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>	yes	reactome/R-HSA-975122.md	Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation<br>	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	390	R-HSA-975139	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation	yes	reactome/R-HSA-975139.md	IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	391	R-HSA-975142	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation	yes	reactome/R-HSA-975142.md	Pellino binds hp-IRAK1:TRAF6 upon TLR7/8 or 9 activation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	392	R-HSA-975185	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments	yes	reactome/R-HSA-975185.md	IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAF6	genes/human/TRAF6/TRAF6-ai-review.yaml	TRAF6	Q9Y4K3	NCBITaxon:9606	Homo sapiens	393	R-HSA-975188	TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation	yes	reactome/R-HSA-975188.md	TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		REMOVE	TRAF6 may indirectly affect heart rate through inflammatory pathways.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	19	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	The extracellular-region annotation comes from a broad Reactome neutrophil-degranulation event and is not supported as a core TRAPPC1 localization.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	20	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	The azurophil-granule-lumen annotation is inherited from a broad Reactome degranulation context and lacks TRAPPC1-specific support.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	21	R-HSA-5694409	Nucleotide exchange on RAB1	yes	reactome/R-HSA-5694409.md	Nucleotide exchange on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places TRAPPC1-containing TRAPPC events in the cytosol/cytosolic face of ER-Golgi trafficking reactions.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	22	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places TRAPPC1-containing TRAPPC events in the cytosol/cytosolic face of ER-Golgi trafficking reactions.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	23	R-HSA-5694439	COPII coat binds TRAPPCII and RAB1:GDP	yes	reactome/R-HSA-5694439.md	COPII coat binds TRAPPCII and RAB1:GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places TRAPPC1-containing TRAPPC events in the cytosol/cytosolic face of ER-Golgi trafficking reactions.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	24	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places TRAPPC1-containing TRAPPC events in the cytosol/cytosolic face of ER-Golgi trafficking reactions.
human	TRAPPC1	genes/human/TRAPPC1/TRAPPC1-ai-review.yaml	TRAPPC1	Q9Y5R8	NCBITaxon:9606	Homo sapiens	25	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places TRAPPC1-containing TRAPPC events in the cytosol/cytosolic face of ER-Golgi trafficking reactions.
human	TRAPPC11	genes/human/TRAPPC11/TRAPPC11-ai-review.yaml	TRAPPC11	Q7Z392	NCBITaxon:9606	Homo sapiens	14	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TRAPPC11 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC12	genes/human/TRAPPC12/TRAPPC12-ai-review.yaml	TRAPPC12	Q8WVT3	NCBITaxon:9606	Homo sapiens	25	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TRAPPC12-containing TRAPP trafficking reactions.
human	TRAPPC13	genes/human/TRAPPC13/TRAPPC13-ai-review.yaml	TRAPPC13	A5PLN9	NCBITaxon:9606	Homo sapiens	9	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is consistent with TRAPPC13-containing TRAPP trafficking reactions.
human	TRAPPC3	genes/human/TRAPPC3/TRAPPC3-ai-review.yaml	TRAPPC3	O43617	NCBITaxon:9606	Homo sapiens	34	R-HSA-5694409	Nucleotide exchange on RAB1	yes	reactome/R-HSA-5694409.md	Nucleotide exchange on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAPPC3-containing TRAPP reactions occur on the cytosolic/cytoplasmic side of ER-Golgi trafficking membranes.
human	TRAPPC3	genes/human/TRAPPC3/TRAPPC3-ai-review.yaml	TRAPPC3	O43617	NCBITaxon:9606	Homo sapiens	35	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAPPC3-containing TRAPP reactions occur on the cytosolic/cytoplasmic side of ER-Golgi trafficking membranes.
human	TRAPPC3	genes/human/TRAPPC3/TRAPPC3-ai-review.yaml	TRAPPC3	O43617	NCBITaxon:9606	Homo sapiens	36	R-HSA-5694439	COPII coat binds TRAPPCII and RAB1:GDP	yes	reactome/R-HSA-5694439.md	COPII coat binds TRAPPCII and RAB1:GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAPPC3-containing TRAPP reactions occur on the cytosolic/cytoplasmic side of ER-Golgi trafficking membranes.
human	TRAPPC3	genes/human/TRAPPC3/TRAPPC3-ai-review.yaml	TRAPPC3	O43617	NCBITaxon:9606	Homo sapiens	37	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAPPC3-containing TRAPP reactions occur on the cytosolic/cytoplasmic side of ER-Golgi trafficking membranes.
human	TRAPPC3	genes/human/TRAPPC3/TRAPPC3-ai-review.yaml	TRAPPC3	O43617	NCBITaxon:9606	Homo sapiens	38	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TRAPPC3-containing TRAPP reactions occur on the cytosolic/cytoplasmic side of ER-Golgi trafficking membranes.
human	TRAPPC4	genes/human/TRAPPC4/TRAPPC4-ai-review.yaml	TRAPPC4	Q9Y296	NCBITaxon:9606	Homo sapiens	34	R-HSA-5694409	Nucleotide exchange on RAB1	yes	reactome/R-HSA-5694409.md	Nucleotide exchange on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC4 as a cytosolic/peripheral TRAPP trafficking subunit.
human	TRAPPC4	genes/human/TRAPPC4/TRAPPC4-ai-review.yaml	TRAPPC4	Q9Y296	NCBITaxon:9606	Homo sapiens	35	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC4 as a cytosolic/peripheral TRAPP trafficking subunit.
human	TRAPPC4	genes/human/TRAPPC4/TRAPPC4-ai-review.yaml	TRAPPC4	Q9Y296	NCBITaxon:9606	Homo sapiens	36	R-HSA-5694439	COPII coat binds TRAPPCII and RAB1:GDP	yes	reactome/R-HSA-5694439.md	COPII coat binds TRAPPCII and RAB1:GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC4 as a cytosolic/peripheral TRAPP trafficking subunit.
human	TRAPPC4	genes/human/TRAPPC4/TRAPPC4-ai-review.yaml	TRAPPC4	Q9Y296	NCBITaxon:9606	Homo sapiens	37	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC4 as a cytosolic/peripheral TRAPP trafficking subunit.
human	TRAPPC4	genes/human/TRAPPC4/TRAPPC4-ai-review.yaml	TRAPPC4	Q9Y296	NCBITaxon:9606	Homo sapiens	38	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC4 as a cytosolic/peripheral TRAPP trafficking subunit.
human	TRAPPC5	genes/human/TRAPPC5/TRAPPC5-ai-review.yaml	TRAPPC5	Q8IUR0	NCBITaxon:9606	Homo sapiens	22	R-HSA-5694409	Nucleotide exchange on RAB1	yes	reactome/R-HSA-5694409.md	Nucleotide exchange on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC5 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC5	genes/human/TRAPPC5/TRAPPC5-ai-review.yaml	TRAPPC5	Q8IUR0	NCBITaxon:9606	Homo sapiens	23	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC5 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC5	genes/human/TRAPPC5/TRAPPC5-ai-review.yaml	TRAPPC5	Q8IUR0	NCBITaxon:9606	Homo sapiens	24	R-HSA-5694439	COPII coat binds TRAPPCII and RAB1:GDP	yes	reactome/R-HSA-5694439.md	COPII coat binds TRAPPCII and RAB1:GDP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC5 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC5	genes/human/TRAPPC5/TRAPPC5-ai-review.yaml	TRAPPC5	Q8IUR0	NCBITaxon:9606	Homo sapiens	25	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC5 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC5	genes/human/TRAPPC5/TRAPPC5-ai-review.yaml	TRAPPC5	Q8IUR0	NCBITaxon:9606	Homo sapiens	26	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC5 as a soluble/peripheral TRAPP trafficking subunit.
human	TRAPPC8	genes/human/TRAPPC8/TRAPPC8-ai-review.yaml	TRAPPC8	Q9Y2L5	NCBITaxon:9606	Homo sapiens	14	R-HSA-8877475	TRAPPC complexes exchange GTP for GDP on RAB1	yes	reactome/R-HSA-8877475.md	TRAPPC complexes exchange GTP for GDP on RAB1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization is consistent with TRAPPC8/TRAPPIII trafficking biology.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	261	R-HSA-210289	Recruitment of SYK to p-DAP12	yes	reactome/R-HSA-210289.md	Recruitment of SYK to p-DAP12	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	262	R-HSA-210300	Interaction of DAP12 and TREM2	yes	reactome/R-HSA-210300.md	Interaction of DAP12 and TREM2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	263	R-HSA-2395412	Phosphorylation of SYK	yes	reactome/R-HSA-2395412.md	Phosphorylation of SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	264	R-HSA-2395801	Phosphorylation of LAT by p-SYK	yes	reactome/R-HSA-2395801.md	Phosphorylation of LAT by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	265	R-HSA-2396594	Phosphorylation of SLP-76 by p-SYK	yes	reactome/R-HSA-2396594.md	Phosphorylation of SLP-76 by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	266	R-HSA-2424480	PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-2424480.md	PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	267	R-HSA-2424482	p85 regulatory unit of PI3K binds p-6Y-SYK	yes	reactome/R-HSA-2424482.md	p85 regulatory unit of PI3K binds p-6Y-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	268	R-HSA-2424484	Phosphorylation of BTK by p-SYK	yes	reactome/R-HSA-2424484.md	Phosphorylation of BTK by p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	269	R-HSA-2424486	Phosphorylation and activation of VAV2/VAV3 by SYK	yes	reactome/R-HSA-2424486.md	Phosphorylation and activation of VAV2/VAV3 by SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	270	R-HSA-2424487	Phosphorylation of PLC-gamma by p-BTK/p-SYK	yes	reactome/R-HSA-2424487.md	Phosphorylation of PLC-gamma by p-BTK/p-SYK	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	271	R-HSA-416725	SEMA6D binds to PLXNA1:TREM2:DAP12	yes	reactome/R-HSA-416725.md	SEMA6D binds to PLXNA1:TREM2:DAP12	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TREM2	genes/human/TREM2/TREM2-ai-review.yaml	TREM2	Q9NZC2	NCBITaxon:9606	Homo sapiens	272	R-HSA-5696358	TREM,CD300 binds lipids	yes	reactome/R-HSA-5696358.md	TREM,CD300 binds lipids	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	TREM2 localization to plasma membrane is consistent with its type I cell-surface receptor role.
human	TRIM13	genes/human/TRIM13/TRIM13-ai-review.yaml	TRIM13	O60858	NCBITaxon:9606	Homo sapiens	15	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of TRIM13 ubiquitin ligase activity in the ERAD pathway. Core MF.
human	TRIM13	genes/human/TRIM13/TRIM13-ai-review.yaml	TRIM13	O60858	NCBITaxon:9606	Homo sapiens	16	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	Reactome pathway-context placement of TRIM13 within ER quality control; mannose trimming itself is performed by ER mannosidases, not TRIM13.
human	TRIM13	genes/human/TRIM13/TRIM13-ai-review.yaml	TRIM13	O60858	NCBITaxon:9606	Homo sapiens	22	R-HSA-8867288	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	yes	reactome/R-HSA-8867288.md	OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome curation of ER membrane localization in the ERAD pathway. Core localization.
human	TRIM5	genes/human/TRIM5/TRIM5-ai-review.yaml	TRIM5	Q9C035	NCBITaxon:9606	Homo sapiens	39	R-HSA-1031716	Expression of IFNG-stimulated genes	yes	reactome/R-HSA-1031716.md	Expression of IFNG-stimulated genes	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of cytosolic localization in the interferon-gamma-stimulated gene context.
human	TRIP4	genes/human/TRIP4/TRIP4-ai-review.yaml	TRIP4	Q15650	NCBITaxon:9606	Homo sapiens	16	R-HSA-9948291	Reactome RQC pathway (cytosol localization of ASC-1/RQT complex)	yes	reactome/R-HSA-9948291.md	RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (RQC pathway), consistent with the site of the ASC-1/RQT complex action on collided ribosomes.
human	TRIP4	genes/human/TRIP4/TRIP4-ai-review.yaml	TRIP4	Q15650	NCBITaxon:9606	Homo sapiens	17	R-HSA-9948300	Reactome RQC pathway (cytosol localization of ASC-1/RQT complex)	yes	reactome/R-HSA-9948300.md	RQT complex:K63polyUb-80S ribosome dissociates yielding K63polyUb-40S subunit and 60S subunit:peptidyl-tRNA with nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (RQC pathway), redundant with the other cytosol annotations.
human	TRMT6	genes/human/TRMT6/TRMT6-ai-review.yaml	TRMT6	Q9UJA5	NCBITaxon:9606	Homo sapiens	16	R-HSA-6783492	TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)	yes	reactome/R-HSA-6783492.md	TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the TRMT6:TRMT61A methylation reaction in the nucleoplasm.
human	TRMT61A	genes/human/TRMT61A/TRMT61A-ai-review.yaml	TRMT61A	Q96FX7	NCBITaxon:9606	Homo sapiens	22	R-HSA-6783492	TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)	yes	reactome/R-HSA-6783492.md	TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome places the TRMT6:TRMT61A methylation reaction in the nucleoplasm.
human	TSG101	genes/human/TSG101/TSG101-ai-review.yaml	TSG101	Q99816	NCBITaxon:9606	Homo sapiens	102	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to ESCRT-I cargo sorting.
human	TSG101	genes/human/TSG101/TSG101-ai-review.yaml	TSG101	Q99816	NCBITaxon:9606	Homo sapiens	103	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to ESCRT-I cargo sorting.
human	TSG101	genes/human/TSG101/TSG101-ai-review.yaml	TSG101	Q99816	NCBITaxon:9606	Homo sapiens	104	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to ESCRT-I cargo sorting.
human	TSG101	genes/human/TSG101/TSG101-ai-review.yaml	TSG101	Q99816	NCBITaxon:9606	Homo sapiens	105	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to ESCRT-I cargo sorting.
human	TSG101	genes/human/TSG101/TSG101-ai-review.yaml	TSG101	Q99816	NCBITaxon:9606	Homo sapiens	106	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to ESCRT-I cargo sorting.
human	TTC8	genes/human/TTC8/TTC8-ai-review.yaml	TTC8	Q8TAM2	NCBITaxon:9606	Homo sapiens	20	R-HSA-5617815	BBSome binds RAB3IP	yes	reactome/R-HSA-5617815.md	BBSome binds RAB3IP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (BBSome binds RAB3IP) places the soluble BBSome in the cytosol. The BBSome assembles in the cytosol before ciliary delivery, so this is accurate but a non-core, low-specificity location.
human	TTC8	genes/human/TTC8/TTC8-ai-review.yaml	TTC8	Q8TAM2	NCBITaxon:9606	Homo sapiens	21	R-HSA-5624125	Formation of the BBSome	yes	reactome/R-HSA-5624125.md	Formation of the BBSome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (Formation of the BBSome) cytosolic location of the assembling complex. Accurate but generic.
human	TTC8	genes/human/TTC8/TTC8-ai-review.yaml	TTC8	Q8TAM2	NCBITaxon:9606	Homo sapiens	22	R-HSA-5624126	ARL6:GTP and the BBSome bind ciliary cargo	yes	reactome/R-HSA-5624126.md	ARL6:GTP and the BBSome bind ciliary cargo	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (ARL6:GTP and BBSome bind ciliary cargo) cytosolic location. Accurate but generic.
human	TTC8	genes/human/TTC8/TTC8-ai-review.yaml	TTC8	Q8TAM2	NCBITaxon:9606	Homo sapiens	23	R-HSA-5624127	ARL6:GTP and the BBSome target cargo to the primary cilium	yes	reactome/R-HSA-5624127.md	ARL6:GTP and the BBSome target cargo to the primary cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (ARL6:GTP and BBSome target cargo to the primary cilium) cytosolic location. Accurate but generic.
human	TTC8	genes/human/TTC8/TTC8-ai-review.yaml	TTC8	Q8TAM2	NCBITaxon:9606	Homo sapiens	24	R-HSA-5624129	LZTFL1 binds the BBSome and prevents its traffic to the cilium	yes	reactome/R-HSA-5624129.md	LZTFL1 binds the BBSome and prevents its traffic to the cilium	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome (LZTFL1 binds the BBSome and prevents its traffic to the cilium) cytosolic location. Consistent with PMID:22072986. Accurate but generic.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	8	R-HSA-5223345	Miscellaneous transport and binding events	yes	reactome/R-HSA-5223345.md	Miscellaneous transport and binding events	Homo sapiens	GO:0055085	transmembrane transport	TAS	involved_in	BP	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS to the generic ""transmembrane transport"" process, derived from the proposed magnesium-transport role. Uninformative and reflecting a role that is peripheral (at most indirect) to TUSC3's core OST function."
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	14	R-HSA-446209	Transfer of N-glycan to the protein	yes	reactome/R-HSA-446209.md	Transfer of N-glycan to the protein	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localizing TUSC3 to the ER membrane in the asparagine N-linked glycosylation pathway. Correct core CC.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	15	R-HSA-9694793	Spike protein gets N-glycosylated	yes	reactome/R-HSA-9694793.md	Spike protein gets N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (SARS-CoV-2 spike protein N-glycosylation pathway) placing TUSC3 at the ER membrane. Location is correct; the specific viral pathway context reflects OST acting on a viral glycoprotein substrate.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	16	R-HSA-9918962	E is N-glycosylated	yes	reactome/R-HSA-9918962.md	E is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral envelope E protein N-glycosylation) placing TUSC3 at the ER membrane. Correct location.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	17	R-HSA-9918988	pre-M is N-glycosylated	yes	reactome/R-HSA-9918988.md	pre-M is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral pre-M protein N-glycosylation) placing TUSC3 at the ER membrane. Correct location.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	18	R-HSA-9919011	Pre-NS1 folds and is N-glycosylated	yes	reactome/R-HSA-9919011.md	Pre-NS1 folds and is N-glycosylated	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (viral pre-NS1 folding and N-glycosylation) placing TUSC3 at the ER membrane. Correct location.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	19	R-HSA-9931286	CD274 N-linked glycosylation in ER	yes	reactome/R-HSA-9931286.md	CD274 N-linked glycosylation in ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (CD274/PD-L1 N-linked glycosylation in ER) placing TUSC3 at the ER membrane. Correct location.
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	20	R-HSA-5339528	TUSC3 transports Mg2+ from extracellular region to cytosol	yes	reactome/R-HSA-5339528.md	TUSC3 transports Mg2+ from extracellular region to cytosol	Homo sapiens	GO:0015095	magnesium ion transmembrane transporter activity	TAS	enables	MF	false		MARK_AS_OVER_ANNOTATED	"Reactome TAS asserting TUSC3 enables magnesium ion transmembrane transporter activity (in a reaction ""TUSC3 transports Mg2+ from extracellular region to cytosol""). TUSC3 has no demonstrated intrinsic transporter/channel activity; its established MF is a thioredoxin-like oxidoreductase."
human	TUSC3	genes/human/TUSC3/TUSC3-ai-review.yaml	TUSC3	Q13454	NCBITaxon:9606	Homo sapiens	22	R-HSA-5339528	TUSC3 transports Mg2+ from extracellular region to cytosol	yes	reactome/R-HSA-5339528.md	TUSC3 transports Mg2+ from extracellular region to cytosol	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome TAS placing TUSC3 in the plasma membrane, tied to the proposed Mg2+-transport reaction. This contradicts the established ER-membrane localization; TUSC3 is an ER OST subunit and shows minimal cell-surface exposure.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	28	R-NUL-9617742	Reactome pathway annotation	no				GO:0004791	thioredoxin-disulfide reductase (NADPH) activity	TAS	enables	MF	false		REMOVE	Reactome annotation. Note that this GO term describes the activity of thioredoxin reductase, not thioredoxin itself.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	31	R-NUL-9617742	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome TAS annotation for nucleoplasm localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	32	R-HSA-111751	Reactome pathway - Ribonucleotide reductase reaction	yes	reactome/R-HSA-111751.md	RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for Trx1 participation in ribonucleotide reductase reaction.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	33	R-HSA-111804	Reactome pathway annotation	yes	reactome/R-HSA-111804.md	RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	34	R-HSA-1250280	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	35	R-HSA-3225851	Reactome pathway annotation	yes	reactome/R-HSA-3225851.md	ROS oxidize thioredoxin and activate MAP3K5	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	36	R-HSA-3341343	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	37	R-HSA-3697882	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	38	R-HSA-5676917	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	39	R-HSA-5676940	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	40	R-HSA-73646	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	63	R-HSA-1250264	Reactome pathway - TXNIP binding to reduced thioredoxin	yes	reactome/R-HSA-1250264.md	TXNIP binds reduced thioredoxin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TXNIP binding to reduced thioredoxin in cytosol.
human	TXN	genes/human/TXN/TXN-ai-review.yaml	TXN	P10599	NCBITaxon:9606	Homo sapiens	64	R-HSA-9796045	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for cytosolic localization.
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	8	R-HSA-209815	Tyrosine is monoiodinated	yes	reactome/R-HSA-209815.md	Tyrosine is monoiodinated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation derived from the thyroxine-biosynthesis reaction context (EFP1/DUOX thyroid H2O2 system at the follicular apical membrane).
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	9	R-HSA-209840	Two DITs combine to form thyroxine	yes	reactome/R-HSA-209840.md	Two DITs combine to form thyroxine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation from the thyroxine-biosynthesis (DUOX) reaction context.
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	10	R-HSA-209925	DIT and MIT combine to form triiodothyronine	yes	reactome/R-HSA-209925.md	DIT and MIT combine to form triiodothyronine	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation from the thyroxine-biosynthesis (DUOX) reaction context.
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	11	R-HSA-209973	Tyrosine is diiodinated	yes	reactome/R-HSA-209973.md	Tyrosine is diiodinated	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation from the thyroxine-biosynthesis (DUOX) reaction context.
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	12	R-HSA-350901	Iodide is organified	yes	reactome/R-HSA-350901.md	Iodide is organified	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation from the thyroxine-biosynthesis (DUOX) reaction context.
human	TXNDC11	genes/human/TXNDC11/TXNDC11-ai-review.yaml	TXNDC11	Q6PKC3	NCBITaxon:9606	Homo sapiens	13	R-HSA-5693681	DUOX1 reduces O2 to H2O2	yes	reactome/R-HSA-5693681.md	DUOX1 reduces O2 to H2O2	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome plasma-membrane annotation from the DUOX1 H2O2-generating reaction context.
human	TYMP	genes/human/TYMP/TYMP-ai-review.yaml	TYMP	P19971	NCBITaxon:9606	Homo sapiens	19	R-HSA-112265	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]	yes	reactome/R-HSA-112265.md	thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome localizes TYMP's catalytic reaction to the cytosol. Consistent with the IBA cytosol annotation.
human	TYMP	genes/human/TYMP/TYMP-ai-review.yaml	TYMP	P19971	NCBITaxon:9606	Homo sapiens	20	R-HSA-112266	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]	yes	reactome/R-HSA-112266.md	thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome localizes the reverse (synthetic) TYMP reaction to the cytosol. Consistent with the IBA and other cytosol annotations.
human	TYMS	genes/human/TYMS/TYMS-ai-review.yaml	TYMS	P04818	NCBITaxon:9606	Homo sapiens	32	R-HSA-73605	conversion of dUMP to dTMP	yes	reactome/R-HSA-73605.md	conversion of dUMP to dTMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome traceable statement placing thymidylate synthase in the cytosol, where it catalyses the conversion of dUMP to dTMP as a homodimer.
human	TYMS	genes/human/TYMS/TYMS-ai-review.yaml	TYMS	P04818	NCBITaxon:9606	Homo sapiens	33	R-HSA-8962050	TYMS gene expression	yes	reactome/R-HSA-8962050.md	TYMS gene expression	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosol annotation associated with the TYMS gene expression event (E2F1-regulated expression). Consistent with the enzyme's established cytosolic localization.
human	UAP1	genes/human/UAP1/UAP1-ai-review.yaml	UAP1	Q16222	NCBITaxon:9606	Homo sapiens	19	R-HSA-446204	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine	yes	reactome/R-HSA-446204.md	GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome traceable-author statement for cytosolic localization of UAP1, the site of UDP-GlcNAc synthesis. Non-core location, concordant with the IDA/IBA cytosol annotations.
human	UBA7	genes/human/UBA7/UBA7-ai-review.yaml	UBA7	P41226	NCBITaxon:9606	Homo sapiens	28	R-HSA-5653754	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA	yes	reactome/R-HSA-5653754.md	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Curated annotation from Reactome showing UBA7 localizes to nucleoplasm where it can ISGylate nuclear proteins including monoubiquitinated PCNA.
human	UBA7	genes/human/UBA7/UBA7-ai-review.yaml	UBA7	P41226	NCBITaxon:9606	Homo sapiens	29	R-HSA-1169397	Activation of ISG15 by UBA7 E1 ligase	yes	reactome/R-HSA-1169397.md	Activation of ISG15 by UBA7 E1 ligase	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated annotation from Reactome pathway 'Activation of ISG15 by UBA7 E1 ligase' showing cytosolic localization where ISG15 activation occurs. Falcon deep research independently supports cytosolic/intracellular ISGylation as the dominant site of UBA7 activity.
human	UBA7	genes/human/UBA7/UBA7-ai-review.yaml	UBA7	P41226	NCBITaxon:9606	Homo sapiens	30	R-HSA-1169404	Transfer of ISG15 from E1 to E2 (UBCH8)	yes	reactome/R-HSA-1169404.md	Transfer of ISG15 from E1 to E2 (UBCH8)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated annotation from Reactome pathway 'Transfer of ISG15 from E1 to E2 (UBCH8)' confirming cytosolic localization.
human	UBA7	genes/human/UBA7/UBA7-ai-review.yaml	UBA7	P41226	NCBITaxon:9606	Homo sapiens	31	R-HSA-936563	ISGylation of DDX58	yes	reactome/R-HSA-936563.md	ISGylation of DDX58	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Curated annotation from Reactome pathway 'ISGylation of DDX58' showing cytosolic localization for ISGylation of RIG-I.
human	UBA7	genes/human/UBA7/UBA7-ai-review.yaml	UBA7	P41226	NCBITaxon:9606	Homo sapiens	32	R-HSA-9927247	ISGylation of DDX58 (RIG-I)	yes	reactome/R-HSA-9927247.md	ISGylation of DDX58 (RIG-I)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Another Reactome annotation for ISGylation of DDX58 (RIG-I) in cytosol. Multiple consistent cytosolic annotations from curated pathways.
human	UBAP1	genes/human/UBAP1/UBAP1-ai-review.yaml	UBAP1	Q9NZ09	NCBITaxon:9606	Homo sapiens	17	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to UBAP1/ESCRT-I function.
human	UBAP1	genes/human/UBAP1/UBAP1-ai-review.yaml	UBAP1	Q9NZ09	NCBITaxon:9606	Homo sapiens	18	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to UBAP1/ESCRT-I function.
human	UBAP1	genes/human/UBAP1/UBAP1-ai-review.yaml	UBAP1	Q9NZ09	NCBITaxon:9606	Homo sapiens	19	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to UBAP1/ESCRT-I function.
human	UBAP1	genes/human/UBAP1/UBAP1-ai-review.yaml	UBAP1	Q9NZ09	NCBITaxon:9606	Homo sapiens	20	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to UBAP1/ESCRT-I function.
human	UBAP1	genes/human/UBAP1/UBAP1-ai-review.yaml	UBAP1	Q9NZ09	NCBITaxon:9606	Homo sapiens	21	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to UBAP1/ESCRT-I function.
human	UBE2T	genes/human/UBE2T/UBE2T-ai-review.yaml	UBE2T	Q9NPD8	NCBITaxon:9606	Homo sapiens	13	R-HSA-8852130	UBA1 conjugates ubiquitin to nuclear E2 enzymes	yes	reactome/R-HSA-8852130.md	UBA1 conjugates ubiquitin to nuclear E2 enzymes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm location, from the reaction in which E1 (UBA1) charges nuclear E2 enzymes with ubiquitin.
human	UBE2T	genes/human/UBE2T/UBE2T-ai-review.yaml	UBE2T	Q9NPD8	NCBITaxon:9606	Homo sapiens	14	R-HSA-6785361	Monoubiquitination of FANCD2:FANCI	yes	reactome/R-HSA-6785361.md	Monoubiquitination of FANCD2:FANCI	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm location, from the FANCD2:FANCI monoubiquitination reaction of the FA pathway.
human	UBE2T	genes/human/UBE2T/UBE2T-ai-review.yaml	UBE2T	Q9NPD8	NCBITaxon:9606	Homo sapiens	16	R-HSA-6785342	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	yes	reactome/R-HSA-6785342.md	FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm location, from the reaction in which the FANCD2:FANCI complex and UBE2T bind ICL-DNA associated with the FA core complex.
human	UBE2T	genes/human/UBE2T/UBE2T-ai-review.yaml	UBE2T	Q9NPD8	NCBITaxon:9606	Homo sapiens	17	R-HSA-6788385	The complex of ATR and ATRIP is recruited to ICL-DNA	yes	reactome/R-HSA-6788385.md	The complex of ATR and ATRIP is recruited to ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm location, associated with FA-pathway reactions at ICL-DNA.
human	UBE2T	genes/human/UBE2T/UBE2T-ai-review.yaml	UBE2T	Q9NPD8	NCBITaxon:9606	Homo sapiens	18	R-HSA-6788392	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	yes	reactome/R-HSA-6788392.md	ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm location, associated with FA-pathway reactions at ICL-DNA.
human	UCHL1	genes/human/UCHL1/UCHL1-ai-review.yaml	UCHL1	P09936	NCBITaxon:9606	Homo sapiens	17	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	UCHL1 participates in protein deubiquitination through hydrolysis of ubiquitin C-terminal adducts and recycling of monoubiquitin.
human	UCHL1	genes/human/UCHL1/UCHL1-ai-review.yaml	UCHL1	P09936	NCBITaxon:9606	Homo sapiens	18	R-HSA-5690319	UCHL1, UCHL3 cleave ubiquitin adducts	yes	reactome/R-HSA-5690319.md	UCHL1, UCHL3 cleave ubiquitin adducts	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	UCHL1 directly enables cysteine-type deubiquitinase / ubiquitin C-terminal hydrolase activity.
human	UCHL1	genes/human/UCHL1/UCHL1-ai-review.yaml	UCHL1	P09936	NCBITaxon:9606	Homo sapiens	32	R-HSA-5690319	UCHL1, UCHL3 cleave ubiquitin adducts	yes	reactome/R-HSA-5690319.md	UCHL1, UCHL3 cleave ubiquitin adducts	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is an appropriate core cellular location for soluble UCHL1 deubiquitinase activity.
human	UCK1	genes/human/UCK1/UCK1-ai-review.yaml	UCK1	Q9HA47	NCBITaxon:9606	Homo sapiens	16	R-HSA-73599	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]	yes	reactome/R-HSA-73599.md	cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome explicitly describes UCK1 as cytosolic in the cytidine/uridine phosphorylation reaction, but this conflicts with later UCK1-GFP evidence reporting predominant nuclear localization. The cytosol row is therefore accepted as Reactome pathway-supported but not as the sole or best localization for UCK1.
human	UCK2	genes/human/UCK2/UCK2-ai-review.yaml	UCK2	Q9BZX2	NCBITaxon:9606	Homo sapiens	22	R-HSA-109903	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]	yes	reactome/R-HSA-109903.md	cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Traceable Author Statement) annotation based on Reactome pathway annotation. Reactome describes UCK2 as cytosolic. This is consistent with experimental localization data.
human	UCKL1	genes/human/UCKL1/UCKL1-ai-review.yaml	UCKL1	Q9NWZ5	NCBITaxon:9606	Homo sapiens	15	R-HSA-73614	Pyrimidine salvage	yes	reactome/R-HSA-73614.md	Pyrimidine salvage	Homo sapiens	GO:0043097	pyrimidine nucleoside salvage	TAS	involved_in	BP	false		ACCEPT	Reactome places UCKL1 in pyrimidine nucleoside salvage, consistent with direct uridine and cytidine phosphorylation.
human	UCKL1	genes/human/UCKL1/UCKL1-ai-review.yaml	UCKL1	Q9NWZ5	NCBITaxon:9606	Homo sapiens	20	R-HSA-8954327	UCKL1 phosphorylates urindine, cytidine	yes	reactome/R-HSA-8954327.md	UCKL1 phosphorylates urindine, cytidine	Homo sapiens	GO:0004849	uridine kinase activity	TAS	enables	MF	false		ACCEPT	Reactome's uridine-phosphorylation event predates direct UCKL1 enzymology but is now confirmed by the 2022 biochemical study.
human	UCKL1	genes/human/UCKL1/UCKL1-ai-review.yaml	UCKL1	Q9NWZ5	NCBITaxon:9606	Homo sapiens	23	R-HSA-8954327	UCKL1 phosphorylates urindine, cytidine	yes	reactome/R-HSA-8954327.md	UCKL1 phosphorylates urindine, cytidine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome models the UCKL1 phosphorylation event in the cytosol, a more specific location compatible with the experimentally observed cytoplasmic pool.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	40	R-HSA-9755507	Reactome: KEAP1-NFE2L2 / cytosol localization	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	41	R-HSA-9758088	Reactome: cytosol localization	yes	reactome/R-HSA-9758088.md	UBXN7 binds VCP hexamer:UBF1:NPLOC4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	42	R-HSA-9758090	Reactome: cytosol localization	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	43	R-HSA-9948427	Reactome: cytosol localization	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome cytosolic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	52	R-HSA-5654985	Reactome: nucleoplasm localization (signaling-related pathway)	yes	reactome/R-HSA-5654985.md	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasmic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	53	R-HSA-5654989	Reactome: nucleoplasm localization (signaling-related pathway)	yes	reactome/R-HSA-5654989.md	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasmic localization.
human	UFD1	genes/human/UFD1/UFD1-ai-review.yaml	UFD1	Q92890	NCBITaxon:9606	Homo sapiens	54	R-HSA-6781922	Reactome: nucleoplasm localization	yes	reactome/R-HSA-6781922.md	USP13 binds UFD1L:SKP2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome nucleoplasmic localization.
human	UGCG	genes/human/UGCG/UGCG-ai-review.yaml	UGCG	Q16739	NCBITaxon:9606	Homo sapiens	17	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		ACCEPT	TAS (Reactome) that UGCG is involved in glycosphingolipid biosynthesis. UGCG catalyzes the committed first step (GlcCer synthesis) of this pathway, so the broader biosynthetic-process annotation is a correct core process. Accept.
human	UGCG	genes/human/UGCG/UGCG-ai-review.yaml	UGCG	Q16739	NCBITaxon:9606	Homo sapiens	19	R-HSA-1638104	UGCG transfers glucose to ceramide	yes	reactome/R-HSA-1638104.md	UGCG transfers glucose to ceramide	Homo sapiens	GO:0008120	ceramide glucosyltransferase activity	TAS	enables	MF	false		ACCEPT	"TAS (Reactome) of the core molecular function. Matches the experimental IDA (PMID:8643456), UniProt EC 2.4.1.80 and the Reactome reaction ""UGCG transfers glucose to ceramide"". Accept."
human	UGCG	genes/human/UGCG/UGCG-ai-review.yaml	UGCG	Q16739	NCBITaxon:9606	Homo sapiens	33	R-HSA-1638104	UGCG transfers glucose to ceramide	yes	reactome/R-HSA-1638104.md	UGCG transfers glucose to ceramide	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) Golgi membrane localization, consistent with the experimental IDA (PMID:12873973) and UniProt. Reactome notes UGCG acts on the cytosolic face of the cis-Golgi. Accept.
human	UGGT1	genes/human/UGGT1/UGGT1-ai-review.yaml	UGGT1	Q9NYU2	NCBITaxon:9606	Homo sapiens	15	R-HSA-901032	ER Quality Control Compartment (ERQC)	yes	reactome/R-HSA-901032.md	ER Quality Control Compartment (ERQC)	Homo sapiens	GO:1904380	endoplasmic reticulum mannose trimming	TAS	involved_in	BP	false		REMOVE	TAS annotation from Reactome pathway R-HSA-901032 (ER Quality Control Compartment). UGGT1 is correctly placed in the ERQC pathway by Reactome, but GO:1904380 (ER mannose trimming) specifically describes alpha-1,2-demannosylation. UGGT1 does not trim mannose; it adds glucose. UGGT1 operates in the same quality control pathway as the mannose-trimming enzymes but performs a distinct reaction (reglucosylation). This annotation is incorrect -- UGGT1 was likely erroneously associated with this process term because it is part of the broader ERQC pathway that includes mannose trimming steps.
human	UGGT1	genes/human/UGGT1/UGGT1-ai-review.yaml	UGGT1	Q9NYU2	NCBITaxon:9606	Homo sapiens	16	R-HSA-548884	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b	yes	reactome/R-HSA-548884.md	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b	Homo sapiens	GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity	TAS	enables	MF	false		ACCEPT	"TAS annotation from Reactome reaction R-HSA-548884 which models UGGT1/2 transferring glucose from dolichyl beta-D-glucosyl phosphate to unfolded protein glycans. The Reactome entry states that ""UGGT1 and 2 are able to distinguish proteins with minor folding defects in the ERQC and reglucosylate them."" This correctly captures the core enzymatic function of UGGT1."
human	UGGT1	genes/human/UGGT1/UGGT1-ai-review.yaml	UGGT1	Q9NYU2	NCBITaxon:9606	Homo sapiens	21	R-HSA-548884	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b	yes	reactome/R-HSA-548884.md	UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		ACCEPT	"TAS annotation for ER lumen localization from Reactome reaction R-HSA-548884. UGGT1 is modeled in Reactome as a soluble ER lumen protein that catalyzes the reglucosylation of misfolded glycoproteins. This is consistent with UniProt's annotation of SUBCELLULAR LOCATION as ""Endoplasmic reticulum lumen"" and with the experimental evidence from PMID:10694380 showing ER localization and the presence of an ER retrieval signal (REEL)."
human	UGP2	genes/human/UGP2/UGP2-ai-review.yaml	UGP2	Q16851	NCBITaxon:9606	Homo sapiens	36	R-HSA-70286	UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose	yes	reactome/R-HSA-70286.md	UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome asserts cytosolic UGP2 catalyzing UTP + glucose-1-phosphate to UDP-glucose + pyrophosphate. Cytosol is the precise and correct localization for this enzyme.
human	UGT8	genes/human/UGT8/UGT8-ai-review.yaml	UGT8	Q16880	NCBITaxon:9606	Homo sapiens	16	R-HSA-9840309	Glycosphingolipid biosynthesis	yes	reactome/R-HSA-9840309.md	Glycosphingolipid biosynthesis	Homo sapiens	GO:0006688	glycosphingolipid biosynthetic process	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Correct but generic parent of the specific galactosylceramide biosynthetic process (GO:0006682). GalCer is a glycosphingolipid, so this is accurate; keep as non-core in favor of the more specific process term.
human	UGT8	genes/human/UGT8/UGT8-ai-review.yaml	UGT8	Q16880	NCBITaxon:9606	Homo sapiens	17	R-HSA-6785933	UGT8 transfers Gal from UDP-Gal to CERA	yes	reactome/R-HSA-6785933.md	UGT8 transfers Gal from UDP-Gal to CERA	Homo sapiens	GO:0003851	N-acylsphingosine galactosyltransferase activity	TAS	enables	MF	false		ACCEPT	Reactome reaction (UGT8 transfers Gal from UDP-Gal to CERA) capturing the core catalytic activity. Consistent with all other MF annotations. Correct.
human	UGT8	genes/human/UGT8/UGT8-ai-review.yaml	UGT8	Q16880	NCBITaxon:9606	Homo sapiens	23	R-HSA-6785933	UGT8 transfers Gal from UDP-Gal to CERA	yes	reactome/R-HSA-6785933.md	UGT8 transfers Gal from UDP-Gal to CERA	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome localization to the ER membrane, consistent with UGT8 being a single-pass ER membrane protein. Correct.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	47	R-HSA-5357905	Regulation of TNFR1 signaling	yes	reactome/R-HSA-5357905.md	Regulation of TNFR1 signaling	Homo sapiens	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	ULK1 regulates TNF-induced death signaling through RIPK1 phosphorylation.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	48	R-HSA-1632852	Macroautophagy	yes	reactome/R-HSA-1632852.md	Macroautophagy	Homo sapiens	GO:0016236	macroautophagy	TAS	involved_in	BP	false		ACCEPT	Macroautophagy, the pathway ULK1 initiates.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	49	R-HSA-8934903	Receptor Mediated Mitophagy	yes	reactome/R-HSA-8934903.md	Receptor Mediated Mitophagy	Homo sapiens	GO:0016236	macroautophagy	TAS	involved_in	BP	false		ACCEPT	Macroautophagy, the pathway ULK1 initiates.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	51	R-HSA-5675868	ULK1 phosphorylates ATG13 and RB1CC1	yes	reactome/R-HSA-5675868.md	ULK1 phosphorylates ATG13 and RB1CC1	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity. ULK1's defining activity, supported by an EXP and eight independent IDA experiments.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	52	R-HSA-8876446	p-ULK1 phosphorylates DENND3	yes	reactome/R-HSA-8876446.md	p-ULK1 phosphorylates DENND3	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity. ULK1's defining activity, supported by an EXP and eight independent IDA experiments.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	53	R-HSA-8948146	FUNDC1 is phosphorylated by ULK1 at Ser17	yes	reactome/R-HSA-8948146.md	FUNDC1 is phosphorylated by ULK1 at Ser17	Homo sapiens	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Protein serine/threonine kinase activity. ULK1's defining activity, supported by an EXP and eight independent IDA experiments.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	98	R-HSA-8948136	ULK1 Translocates to the mitochondria	yes	reactome/R-HSA-8948136.md	ULK1 Translocates to the mitochondria	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Mitochondrial outer membrane, from two Reactome mitophagy reactions.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	99	R-HSA-8948146	FUNDC1 is phosphorylated by ULK1 at Ser17	yes	reactome/R-HSA-8948146.md	FUNDC1 is phosphorylated by ULK1 at Ser17	Homo sapiens	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Mitochondrial outer membrane, from two Reactome mitophagy reactions.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	100	R-HSA-1632857	ULK1 phosphorylates AMBRA1:BECN1 complex	yes	reactome/R-HSA-1632857.md	ULK1 phosphorylates AMBRA1:BECN1 complex	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane, the compartment the omegasome is part of.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	101	R-HSA-5679205	ULK1 phosphorylates Beclin-1	yes	reactome/R-HSA-5679205.md	ULK1 phosphorylates Beclin-1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane, the compartment the omegasome is part of.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	102	R-HSA-5679239	ULK complex translocates to the ER	yes	reactome/R-HSA-5679239.md	ULK complex translocates to the ER	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Endoplasmic reticulum membrane, the compartment the omegasome is part of.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	103	R-HSA-8854759	TBC1D14 binds RAB11 and ULK1	yes	reactome/R-HSA-8854759.md	TBC1D14 binds RAB11 and ULK1	Homo sapiens	GO:0055037	recycling endosome	TAS	located_in	CC	false		ACCEPT	ULK1 acts at recycling endosomes involved in autophagosome membrane supply.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	107	R-HSA-5672008	Thr-180 of ULK1 is phosphorylated	yes	reactome/R-HSA-5672008.md	Thr-180 of ULK1 is phosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	108	R-HSA-5675868	ULK1 phosphorylates ATG13 and RB1CC1	yes	reactome/R-HSA-5675868.md	ULK1 phosphorylates ATG13 and RB1CC1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	109	R-HSA-5679239	ULK complex translocates to the ER	yes	reactome/R-HSA-5679239.md	ULK complex translocates to the ER	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	110	R-HSA-8876446	p-ULK1 phosphorylates DENND3	yes	reactome/R-HSA-8876446.md	p-ULK1 phosphorylates DENND3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	111	R-HSA-5665868	AMPK (complex) phosphorylates ULK1 (complex)	yes	reactome/R-HSA-5665868.md	AMPK (complex) phosphorylates ULK1 (complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	112	R-HSA-5672010	Active MTORC1 phosphorylates ULK1	yes	reactome/R-HSA-5672010.md	Active MTORC1 phosphorylates ULK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	113	R-HSA-5673768	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex	yes	reactome/R-HSA-5673768.md	p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	114	R-HSA-5675790	MTORC1 dissociates from ULK complex	yes	reactome/R-HSA-5675790.md	MTORC1 dissociates from ULK complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	115	R-HSA-5683925	ULK1 is dephosphorylated	yes	reactome/R-HSA-5683925.md	ULK1 is dephosphorylated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	118	R-HSA-5672011	p-AMPK:AMP binds the ULK complex	yes	reactome/R-HSA-5672011.md	p-AMPK:AMP binds the ULK complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	119	R-HSA-5672817	Active MTORC1 binds the ULK1 complex	yes	reactome/R-HSA-5672817.md	Active MTORC1 binds the ULK1 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	120	R-HSA-8948136	ULK1 Translocates to the mitochondria	yes	reactome/R-HSA-8948136.md	ULK1 Translocates to the mitochondria	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	ULK1	genes/human/ULK1/ULK1-ai-review.yaml	ULK1	O75385	NCBITaxon:9606	Homo sapiens	121	R-HSA-9819106	ULK1 phosphorylates RIPK1 at S357	yes	reactome/R-HSA-9819106.md	ULK1 phosphorylates RIPK1 at S357	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	ULK1 has a cytosolic pool that exchanges with autophagic membranes.
human	UMPS	genes/human/UMPS/UMPS-ai-review.yaml	UMPS	P11172	NCBITaxon:9606	Homo sapiens	20	R-HSA-73564	UMPS dimer decarboxylates OMP to UMP	yes	reactome/R-HSA-73564.md	UMPS dimer decarboxylates OMP to UMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	UMPS acts in the cytosol; the Reactome-traceable decarboxylation reaction (OMP -> UMP) is annotated to the cytosol. This is the primary subcellular location of the enzyme's catalysis.
human	UMPS	genes/human/UMPS/UMPS-ai-review.yaml	UMPS	P11172	NCBITaxon:9606	Homo sapiens	21	R-HSA-73567	UMPS dimer transfers phosphoribosyl group to ORO to form OMP	yes	reactome/R-HSA-73567.md	UMPS dimer transfers phosphoribosyl group to ORO to form OMP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-traceable OPRT reaction (orotate + PRPP -> OMP) is annotated to the cytosol, consistent with UMPS being a cytosolic enzyme.
human	UPB1	genes/human/UPB1/UPB1-ai-review.yaml	UPB1	Q9UBR1	NCBITaxon:9606	Homo sapiens	22	R-HSA-73591	conversion of 3-ureidopropionate to beta-alanine	yes	reactome/R-HSA-73591.md	conversion of 3-ureidopropionate to beta-alanine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization inferred from the Reactome reaction for conversion of 3-ureidopropionate to beta-alanine.
human	UPB1	genes/human/UPB1/UPB1-ai-review.yaml	UPB1	Q9UBR1	NCBITaxon:9606	Homo sapiens	23	R-HSA-73620	conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate	yes	reactome/R-HSA-73620.md	conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization inferred from the Reactome reaction for conversion of 3-ureidoisobutyrate to 3-aminoisobutyrate (thymine branch).
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	85	R-HSA-927813	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	86	R-HSA-927830	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927830.md	Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	87	R-HSA-927836	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	88	R-HSA-927889	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	93	R-HSA-927789	Reactome: Formation of the SURF complex (cytosol)	yes	reactome/R-HSA-927789.md	Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF1	genes/human/UPF1/UPF1-ai-review.yaml	UPF1	Q92900	NCBITaxon:9606	Homo sapiens	94	R-HSA-927832	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol, consistent with cytoplasmic NMD activity of UPF1.
human	UPF2	genes/human/UPF2/UPF2-ai-review.yaml	UPF2	Q9HAU5	NCBITaxon:9606	Homo sapiens	40	R-HSA-927813	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization, consistent with cytoplasmic NMD activity of UPF2.
human	UPF2	genes/human/UPF2/UPF2-ai-review.yaml	UPF2	Q9HAU5	NCBITaxon:9606	Homo sapiens	41	R-HSA-927832	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization, consistent with cytoplasmic NMD activity of UPF2.
human	UPF2	genes/human/UPF2/UPF2-ai-review.yaml	UPF2	Q9HAU5	NCBITaxon:9606	Homo sapiens	42	R-HSA-927836	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization, consistent with cytoplasmic NMD activity of UPF2.
human	UPF2	genes/human/UPF2/UPF2-ai-review.yaml	UPF2	Q9HAU5	NCBITaxon:9606	Homo sapiens	43	R-HSA-927889	Reactome: nonsense-mediated decay (cytosol)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization, consistent with cytoplasmic NMD activity of UPF2.
human	UPF3A	genes/human/UPF3A/UPF3A-ai-review.yaml	UPF3A	Q9H1J1	NCBITaxon:9606	Homo sapiens	28	R-HSA-927813	Reactome NMD pathway (cytosol localization of UPF3A)	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (NMD pathway), consistent with the cytoplasmic phase of NMD where UPF3A acts.
human	UPF3A	genes/human/UPF3A/UPF3A-ai-review.yaml	UPF3A	Q9H1J1	NCBITaxon:9606	Homo sapiens	29	R-HSA-927832	Reactome NMD pathway (cytosol localization of UPF3A)	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (NMD pathway), redundant with the other cytosol annotations.
human	UPF3A	genes/human/UPF3A/UPF3A-ai-review.yaml	UPF3A	Q9H1J1	NCBITaxon:9606	Homo sapiens	30	R-HSA-927836	Reactome NMD pathway (cytosol localization of UPF3A)	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (NMD pathway).
human	UPF3A	genes/human/UPF3A/UPF3A-ai-review.yaml	UPF3A	Q9H1J1	NCBITaxon:9606	Homo sapiens	31	R-HSA-927889	Reactome NMD pathway (cytosol localization of UPF3A)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization (NMD pathway).
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	44	R-HSA-159101	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-159101.md	NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	45	R-HSA-75096	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-75096.md	Docking of the TAP:EJC Complex with the NPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	46	R-HSA-75097	Reactome: NMD/mRNA processing pathway step	yes	reactome/R-HSA-75097.md	Transport of the export-competent mRNP complex through the NPC	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	47	R-HSA-8849157	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-8849157.md	TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	48	R-HSA-9770131	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-9770131.md	Formation of the Spliceosomal B* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	49	R-HSA-9770141	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-9770141.md	Formation of the Spliceosomal C* complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	50	R-HSA-9770236	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-9770236.md	Formation of the Spliceosomal P complex and exon ligation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	51	R-HSA-9770847	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-9770847.md	Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	52	R-HSA-9794542	Reactome: NMD/mRNA processing pathway step (nucleoplasm localization)	yes	reactome/R-HSA-9794542.md	Formation of the Spliceosomal C complex containing intron lariat	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome-curated nucleoplasmic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	53	R-HSA-75097	Reactome: NMD/mRNA processing pathway step	yes	reactome/R-HSA-75097.md	Transport of the export-competent mRNP complex through the NPC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	54	R-HSA-75098	Reactome: NMD/mRNA processing pathway step (cytosol localization)	yes	reactome/R-HSA-75098.md	mRNP complex dissociates from cytosolic face of NPC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	55	R-HSA-927813	Reactome: NMD/mRNA processing pathway step (cytosol localization)	yes	reactome/R-HSA-927813.md	p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	56	R-HSA-927832	Reactome: NMD/mRNA processing pathway step (cytosol localization)	yes	reactome/R-HSA-927832.md	UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	57	R-HSA-927836	Reactome: NMD/mRNA processing pathway step (cytosol localization)	yes	reactome/R-HSA-927836.md	SMG6 hydrolyzes mRNA with premature termination codon	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPF3B	genes/human/UPF3B/UPF3B-ai-review.yaml	UPF3B	Q9BZI7	NCBITaxon:9606	Homo sapiens	58	R-HSA-927889	Reactome: NMD/mRNA processing pathway step (cytosol localization)	yes	reactome/R-HSA-927889.md	SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-curated cytosolic localization.
human	UPP1	genes/human/UPP1/UPP1-ai-review.yaml	UPP1	Q16831	NCBITaxon:9606	Homo sapiens	19	R-HSA-74372	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]	yes	reactome/R-HSA-74372.md	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core cellular component. Reactome describes UPP1 as a cytosolic uridine phosphorylase; consistent with the IBA cytosol annotation.
human	UPP1	genes/human/UPP1/UPP1-ai-review.yaml	UPP1	Q16831	NCBITaxon:9606	Homo sapiens	20	R-HSA-74376	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)	yes	reactome/R-HSA-74376.md	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Correct core cellular component (reverse-direction Reactome reaction, same cytosolic localization). Consistent with the other cytosol annotations.
human	UPP2	genes/human/UPP2/UPP2-ai-review.yaml	UPP2	O95045	NCBITaxon:9606	Homo sapiens	31	R-HSA-74372	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]	yes	reactome/R-HSA-74372.md	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization for the UPP-catalyzed reaction, consistent with the IBA cytosol annotation. Core localization.
human	UPP2	genes/human/UPP2/UPP2-ai-review.yaml	UPP2	O95045	NCBITaxon:9606	Homo sapiens	32	R-HSA-74376	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)	yes	reactome/R-HSA-74376.md	(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome-asserted cytosolic localization (second Reactome reaction), consistent with the other cytosol annotations. Core localization.
human	UQCRB	genes/human/UQCRB/UQCRB-ai-review.yaml	UQCRB	P14927	NCBITaxon:9606	Homo sapiens	20	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Traceable author statement (Reactome) placing UQCRB in the mitochondrial inner membrane, associated with the reaction ""Electron transfer from ubiquinol to cytochrome c of complex III""."
human	UQCRB	genes/human/UQCRB/UQCRB-ai-review.yaml	UQCRB	P14927	NCBITaxon:9606	Homo sapiens	21	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing UQCRB in the mitochondrial inner membrane, in the context of Complex III assembly (proteolytic processing of the UQCRFS1 subunit).
human	UQCRB	genes/human/UQCRB/UQCRB-ai-review.yaml	UQCRB	P14927	NCBITaxon:9606	Homo sapiens	22	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Traceable author statement (Reactome) placing UQCRB in the mitochondrial inner membrane, in the context of Complex III maturation (TTC19 clearance of UQCRFS1 fragments).
human	UQCRC1	genes/human/UQCRC1/UQCRC1-ai-review.yaml	UQCRC1	P31930	NCBITaxon:9606	Homo sapiens	26	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation for mitochondrial inner membrane from Reactome pathway ""Electron transfer from ubiquinol to cytochrome c of complex III"" (R-HSA-164651). UQCRC1 is a subunit of Complex III which resides in the mitochondrial inner membrane, performing the Q-cycle."
human	UQCRC1	genes/human/UQCRC1/UQCRC1-ai-review.yaml	UQCRC1	P31930	NCBITaxon:9606	Homo sapiens	27	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation for mitochondrial inner membrane from Reactome pathway ""Unknown peptidase cleaves UQCRFS1 subunit"" (R-HSA-9906017). This Reactome entry describes the processing of the UQCRFS1 Rieske protein within Complex III. UQCRC1 is mentioned as a possible candidate for the unknown peptidase. The localization itself (inner membrane) is correct regardless of whether UQCRC1 has peptidase activity."
human	UQCRC1	genes/human/UQCRC1/UQCRC1-ai-review.yaml	UQCRC1	P31930	NCBITaxon:9606	Homo sapiens	28	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation for mitochondrial inner membrane from Reactome pathway ""TTC19 clears UQCRFS1 fragments from Complex III"" (R-HSA-9906042). The localization of UQCRC1 to the inner membrane is correct."
human	UQCRC2	genes/human/UQCRC2/UQCRC2-ai-review.yaml	UQCRC2	P22695	NCBITaxon:9606	Homo sapiens	24	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS for inner-membrane localization, tied to the reaction for electron transfer from ubiquinol to cytochrome c of complex III (the Q cycle). Consistent with UQCRC2 as an inner-membrane CIII subunit.
human	UQCRC2	genes/human/UQCRC2/UQCRC2-ai-review.yaml	UQCRC2	P22695	NCBITaxon:9606	Homo sapiens	25	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (inner membrane) associated with a reaction in which LONP1 binds mitochondrial inner membrane proteins; a protein-quality-control reaction in which UQCRC2, as an inner-membrane protein, is a participant. The localization term itself is correct.
human	UQCRC2	genes/human/UQCRC2/UQCRC2-ai-review.yaml	UQCRC2	P22695	NCBITaxon:9606	Homo sapiens	26	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (inner membrane) associated with a reaction in which LONP1 degrades mitochondrial inner membrane proteins. The inner-membrane localization is correct.
human	UQCRC2	genes/human/UQCRC2/UQCRC2-ai-review.yaml	UQCRC2	P22695	NCBITaxon:9606	Homo sapiens	27	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (inner membrane) associated with a CIII-maturation reaction in which an unknown peptidase cleaves the UQCRFS1 subunit and UQCRC1/UQCRC2 are noted only as possible candidate peptidases. The localization term is correct.
human	UQCRC2	genes/human/UQCRC2/UQCRC2-ai-review.yaml	UQCRC2	P22695	NCBITaxon:9606	Homo sapiens	28	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS (inner membrane) associated with a reaction in which TTC19 clears UQCRFS1 fragments from Complex III. Correct inner-membrane localization for UQCRC2.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	21	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9866272 (2Fe-2S is inserted in UQCRFS1). This Reactome reaction models the [2Fe-2S] cluster insertion step during UQCRFS1 maturation, which occurs at the mitochondrial inner membrane. UQCRFS1 is indeed located in the inner membrane after assembly.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	22	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9906017 (Unknown peptidase cleaves UQCRFS1 subunit). This reaction models the proteolytic processing of UQCRFS1 after its insertion into Complex III at the inner membrane. The localization is correct.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	23	R-HSA-9866253	apo-UQCRFS1 binds LYRM7	yes	reactome/R-HSA-9866253.md	apo-UQCRFS1 binds LYRM7	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway R-HSA-9866253 (apo-UQCRFS1 binds LYRM7). This reaction models the chaperone binding step where apo-UQCRFS1 binds LYRM7 in the mitochondrial matrix prior to Fe-S cluster insertion and BCS1L-mediated translocation. The matrix is the transient location of the apo-protein during assembly, not the final functional location.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	24	R-HSA-9866272	2Fe-2S is inserted in UQCRFS1	yes	reactome/R-HSA-9866272.md	2Fe-2S is inserted in UQCRFS1	Homo sapiens	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway R-HSA-9866272 (2Fe-2S is inserted in UQCRFS1). This reaction occurs in the mitochondrial matrix where the Fe-S transfer complex delivers the [2Fe-2S] cluster to apo-UQCRFS1 bound to LYRM7. As above, matrix localization is a transient assembly state.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	30	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-164651 (Electron transfer from ubiquinol to cytochrome c of complex III). This reaction represents the core catalytic function of Complex III occurring at the inner membrane, where UQCRFS1 participates as the Rieske iron-sulfur subunit.
human	UQCRFS1	genes/human/UQCRFS1/UQCRFS1-ai-review.yaml	UQCRFS1	P47985	NCBITaxon:9606	Homo sapiens	31	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway R-HSA-9906042 (TTC19 clears UQCRFS1 fragments from Complex III). This reaction models the quality control step where TTC19 removes UQCRFS1-derived fragments from the inner membrane Complex III. The localization is correct.
human	UQCRH	genes/human/UQCRH/UQCRH-ai-review.yaml	UQCRH	P07919	NCBITaxon:9606	Homo sapiens	18	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) localization to the mitochondrial inner membrane, from the pathway describing electron transfer from ubiquinol to cytochrome c by Complex III.
human	UQCRH	genes/human/UQCRH/UQCRH-ai-review.yaml	UQCRH	P07919	NCBITaxon:9606	Homo sapiens	19	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization from the CIII assembly pathway (UQCRFS1 processing). Correct localization for the assembled complex context.
human	UQCRH	genes/human/UQCRH/UQCRH-ai-review.yaml	UQCRH	P07919	NCBITaxon:9606	Homo sapiens	20	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) inner-membrane localization from the CIII assembly pathway (TTC19 clearance of UQCRFS1 fragments). Correct localization for the complex context.
human	UQCRQ	genes/human/UQCRQ/UQCRQ-ai-review.yaml	UQCRQ	O14949	NCBITaxon:9606	Homo sapiens	21	R-HSA-164651	Electron transfer from ubiquinol to cytochrome c of complex III	yes	reactome/R-HSA-164651.md	Electron transfer from ubiquinol to cytochrome c of complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"Reactome TAS localization to the mitochondrial inner membrane, from the pathway ""Electron transfer from ubiquinol to cytochrome c of complex III"". Correct core localization for a CIII subunit."
human	UQCRQ	genes/human/UQCRQ/UQCRQ-ai-review.yaml	UQCRQ	O14949	NCBITaxon:9606	Homo sapiens	22	R-HSA-9837978	LONP1 binds mitochondrial inner membrane proteins	yes	reactome/R-HSA-9837978.md	LONP1 binds mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial inner membrane, from a mitochondrial-protein-degradation reaction (LONP1 binding inner-membrane proteins). Correct localization annotation.
human	UQCRQ	genes/human/UQCRQ/UQCRQ-ai-review.yaml	UQCRQ	O14949	NCBITaxon:9606	Homo sapiens	23	R-HSA-9838004	LONP1 degrades mitochondrial inner membrane proteins	yes	reactome/R-HSA-9838004.md	LONP1 degrades mitochondrial inner membrane proteins	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial inner membrane, from a mitochondrial-protein-degradation reaction (LONP1 degrading inner-membrane proteins). Correct localization annotation.
human	UQCRQ	genes/human/UQCRQ/UQCRQ-ai-review.yaml	UQCRQ	O14949	NCBITaxon:9606	Homo sapiens	24	R-HSA-9906017	Unknown peptidase cleaves UQCRFS1 subunit	yes	reactome/R-HSA-9906017.md	Unknown peptidase cleaves UQCRFS1 subunit	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial inner membrane, from a Complex III assembly/maturation reaction (cleavage of the UQCRFS1 subunit). Correct localization for a CIII subunit.
human	UQCRQ	genes/human/UQCRQ/UQCRQ-ai-review.yaml	UQCRQ	O14949	NCBITaxon:9606	Homo sapiens	25	R-HSA-9906042	TTC19 clears UQCRFS1 fragments from Complex III	yes	reactome/R-HSA-9906042.md	TTC19 clears UQCRFS1 fragments from Complex III	Homo sapiens	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	Reactome TAS localization to the mitochondrial inner membrane, from a Complex III maturation reaction (TTC19 clearing UQCRFS1 fragments). Correct localization.
human	UROC1	genes/human/UROC1/UROC1-ai-review.yaml	UROC1	Q96N76	NCBITaxon:9606	Homo sapiens	5	R-HSA-70903	urocanate + H2O => 4-imidazolone-5-propanoate	yes	reactome/R-HSA-70903.md	urocanate + H2O => 4-imidazolone-5-propanoate	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization asserted by Reactome, which designates UROC1 as the cytosolic urocanate hydratase catalyzing urocanate + H2O -> 4-imidazolone-5-propanoate. Consistent with the experimental IDA to the same term. Correct core localization.
human	UROD	genes/human/UROD/UROD-ai-review.yaml	UROD	P06132	NCBITaxon:9606	Homo sapiens	26	R-HSA-189425	UROD decarboxylates URO3 to COPRO3	yes	reactome/R-HSA-189425.md	UROD decarboxylates URO3 to COPRO3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) location in cytosol for the UROD reaction converting uroporphyrinogen III to coproporphyrinogen III. Consistent with the established cytosolic localization.
human	UROD	genes/human/UROD/UROD-ai-review.yaml	UROD	P06132	NCBITaxon:9606	Homo sapiens	27	R-HSA-190182	UROD decarboxylates URO1 to COPRO1	yes	reactome/R-HSA-190182.md	UROD decarboxylates URO1 to COPRO1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS (Reactome) location in cytosol for the UROD reaction converting uroporphyrinogen I to coproporphyrinogen I (the less-efficient isomer I reaction). Consistent with the established cytosolic localization.
human	UROS	genes/human/UROS/UROS-ai-review.yaml	UROS	P10746	NCBITaxon:9606	Homo sapiens	14	R-HSA-189451	Heme biosynthesis	yes	reactome/R-HSA-189451.md	Heme biosynthesis	Homo sapiens	GO:0006783	heme biosynthetic process	TAS	involved_in	BP	false		ACCEPT	UROS is one of the eight enzymes of heme biosynthesis (the fourth step, one of the four cytosolic steps), producing the uroporphyrinogen III precursor.
human	UROS	genes/human/UROS/UROS-ai-review.yaml	UROS	P10746	NCBITaxon:9606	Homo sapiens	15	R-HSA-189488	UROS transforms HMB to URO3	yes	reactome/R-HSA-189488.md	UROS transforms HMB to URO3	Homo sapiens	GO:0004852	uroporphyrinogen-III synthase activity	TAS	enables	MF	false		ACCEPT	Reactome-curated statement of the core catalytic activity (HMB to uroporphyrinogen III).
human	UROS	genes/human/UROS/UROS-ai-review.yaml	UROS	P10746	NCBITaxon:9606	Homo sapiens	18	R-HSA-189488	UROS transforms HMB to URO3	yes	reactome/R-HSA-189488.md	UROS transforms HMB to URO3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome places the UROS reaction in the cytosol.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	26	R-NUL-9646387	Dynein motors transport misfolded proteins	yes	reactome/R-NUL-9646387.md	Dynein motors transport misfolded proteins	Cercopithecus aethiops	GO:0005815	microtubule organizing center	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS from Reactome pathway database. Recent studies show USO1 localizes to spindle poles (centrosomes/ microtubule organizing centers) during mitosis through interaction with gamma-tubulin. This is a well-characterized non-canonical localization important for mitotic spindle function. However, this is a mitosis-specific function, not core to the primary ER-Golgi transport role. Keep as non-core.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	28	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	TAS from Reactome COPI pathway. USO1 associates with transport vesicles (both COPII and COPI) as part of its core function in vesicle tethering and fusion. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	29	R-HSA-6809003	ERGIC-to-Golgi vesicles bind dynein:dynactin	yes	reactome/R-HSA-6809003.md	ERGIC-to-Golgi vesicles bind dynein:dynactin	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Duplicate transport vesicle annotation from different Reactome pathway (ERGIC-to-Golgi vesicles bind dynein). Same core localization, redundant with above. Accept.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	30	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0030133	transport vesicle	TAS	located_in	CC	false		ACCEPT	Duplicate transport vesicle annotation from Reactome vesicle tethering pathway. Redundant. Accept.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	32	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	33	R-HSA-5694446	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	yes	reactome/R-HSA-5694446.md	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	34	R-HSA-6807864	RAB1:GTP recruits GBF1 to the ERGIC	yes	reactome/R-HSA-6807864.md	RAB1:GTP recruits GBF1 to the ERGIC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	35	R-HSA-6807866	GBF1 recruits ARF:GDP to the ERGIC	yes	reactome/R-HSA-6807866.md	GBF1 recruits ARF:GDP to the ERGIC	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	36	R-HSA-6807868	GBF1 stimulates ARF nucleotide exchange	yes	reactome/R-HSA-6807868.md	GBF1 stimulates ARF nucleotide exchange	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	37	R-HSA-6807872	Active ARF recruits coatomer	yes	reactome/R-HSA-6807872.md	Active ARF recruits coatomer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	38	R-HSA-6807875	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	yes	reactome/R-HSA-6807875.md	ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	39	R-HSA-6807877	ARFGAPs stimulate ARF GTPase activity	yes	reactome/R-HSA-6807877.md	ARFGAPs stimulate ARF GTPase activity	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	40	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	41	R-NUL-9646387	Dynein motors transport misfolded proteins	yes	reactome/R-NUL-9646387.md	Dynein motors transport misfolded proteins	Cercopithecus aethiops	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathways. Duplicate cytosol annotation already reviewed with IEA/IBA evidence. USO1 cycles between cytosol and Golgi. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	44	R-HSA-6809006	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	yes	reactome/R-HSA-6809006.md	Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate Golgi membrane annotation already reviewed. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	45	R-HSA-6809010	COPI vesicle uncoating	yes	reactome/R-HSA-6809010.md	COPI vesicle uncoating	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate Golgi membrane annotation already reviewed. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	46	R-HSA-6809011	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	yes	reactome/R-HSA-6809011.md	cis-Golgi t-SNAREs bind YKT6 on tethered vesicle	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate Golgi membrane annotation already reviewed. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	47	R-HSA-5694418	RAB1:GTP binds USO1 and GORASP1:GOLGA2	yes	reactome/R-HSA-5694418.md	RAB1:GTP binds USO1 and GORASP1:GOLGA2	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate ER to Golgi transport vesicle membrane annotation already reviewed. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	48	R-HSA-5694441	CSNK1D phosphorylates SEC23	yes	reactome/R-HSA-5694441.md	CSNK1D phosphorylates SEC23	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate ER to Golgi transport vesicle membrane annotation already reviewed. Accept as core localization.
human	USO1	genes/human/USO1/USO1-ai-review.yaml	USO1	O60763	NCBITaxon:9606	Homo sapiens	49	R-HSA-5694446	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	yes	reactome/R-HSA-5694446.md	BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle	Homo sapiens	GO:0012507	ER to Golgi transport vesicle membrane	TAS	located_in	CC	false		ACCEPT	TAS from Reactome. Duplicate ER to Golgi transport vesicle membrane annotation already reviewed. Accept as core localization.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	34	R-HSA-5688426	Deubiquitination	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	Protein deubiquitination is the broad biological process that best summarizes USP10 catalytic action across multiple substrates.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	35	R-HSA-110313	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	yes	reactome/R-HSA-110313.md	Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	Homo sapiens	GO:0019985	translesion synthesis	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Reactome places USP10 in the PCNA deubiquitination step that terminates/limits translesion synthesis.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	36	R-HSA-5653770	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA	yes	reactome/R-HSA-5653770.md	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	USP10 is a ubiquitin-specific cysteine deubiquitinase; this MF captures the core catalytic activity even though individual papers test different substrates.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	37	R-HSA-5689973	USP10,USP24,USP42 deubiquitinate TP53	yes	reactome/R-HSA-5689973.md	USP10,USP24,USP42 deubiquitinate TP53	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	USP10 is a ubiquitin-specific cysteine deubiquitinase; this MF captures the core catalytic activity even though individual papers test different substrates.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	38	R-HSA-6782106	USP10 deubiquitinates SNX3, CFTR	yes	reactome/R-HSA-6782106.md	USP10 deubiquitinates SNX3, CFTR	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	USP10 is a ubiquitin-specific cysteine deubiquitinase; this MF captures the core catalytic activity even though individual papers test different substrates.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	69	R-HSA-6781779	USP13 deubiquitinates BECN1,USP10	yes	reactome/R-HSA-6781779.md	USP13 deubiquitinates BECN1,USP10	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a supported compartment for USP10 deubiquitinase activity and substrate regulation.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	70	R-HSA-6782106	USP10 deubiquitinates SNX3, CFTR	yes	reactome/R-HSA-6782106.md	USP10 deubiquitinates SNX3, CFTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol is a supported compartment for USP10 deubiquitinase activity and substrate regulation.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	73	R-HSA-5653766	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA	yes	reactome/R-HSA-5653766.md	USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is a supported location for USP10 in PCNA/TLS and TP53 deubiquitination Reactome contexts.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	74	R-HSA-5653770	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA	yes	reactome/R-HSA-5653770.md	USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is a supported location for USP10 in PCNA/TLS and TP53 deubiquitination Reactome contexts.
human	USP10	genes/human/USP10/USP10-ai-review.yaml	USP10	Q14694	NCBITaxon:9606	Homo sapiens	75	R-HSA-5689973	USP10,USP24,USP42 deubiquitinate TP53	yes	reactome/R-HSA-5689973.md	USP10,USP24,USP42 deubiquitinate TP53	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm is a supported location for USP10 in PCNA/TLS and TP53 deubiquitination Reactome contexts.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	12	R-HSA-5688426	Ub-specific processing proteases (protein deubiquitination)	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	Reactome (TAS) curation of USP21 protein deubiquitination, here in the context of ubiquitin-specific processing protease pathways. Consistent with its core process.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	13	R-HSA-5690157	Ub-specific processing proteases (USP21 deubiquitinase activity)	no				GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core DUB activity. Correct and experimentally corroborated.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	14	R-HSA-5690159	Ub-specific processing proteases (USP21 deubiquitinase activity)	no				GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core cysteine-type deubiquitinase activity.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	15	R-HSA-6783177	Ub-specific processing proteases (USP21 deubiquitinase activity)	yes	reactome/R-HSA-6783177.md	USP21 deubiquitinates GATA3,IL33	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome (TAS) annotation of the core cysteine-type deubiquitinase activity.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	18	R-HSA-5690157	Ub-specific processing proteases (USP21 deubiquitinase activity)	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization, consistent with the experimentally supported nuclear pool.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	19	R-HSA-6783177	Ub-specific processing proteases (USP21 deubiquitinase activity)	yes	reactome/R-HSA-6783177.md	USP21 deubiquitinates GATA3,IL33	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) nucleoplasm localization, redundant with the other nucleoplasm annotations and consistent with experimental evidence.
human	USP21	genes/human/USP21/USP21-ai-review.yaml	USP21	Q9UK80	NCBITaxon:9606	Homo sapiens	20	R-HSA-5690159	Ub-specific processing proteases (USP21 deubiquitinase activity)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome (TAS) cytosol localization, consistent with the experimentally supported cytoplasmic pool.
human	USP25	genes/human/USP25/USP25-ai-review.yaml	USP25	Q9UHP3	NCBITaxon:9606	Homo sapiens	26	R-HSA-5688426	Ub-specific processing proteases (deubiquitination)	yes	reactome/R-HSA-5688426.md	Deubiquitination	Homo sapiens	GO:0016579	protein deubiquitination	TAS	involved_in	BP	false		ACCEPT	Reactome curated annotation of protein deubiquitination, the core process of USP25.
human	USP25	genes/human/USP25/USP25-ai-review.yaml	USP25	Q9UHP3	NCBITaxon:9606	Homo sapiens	27	R-HSA-5696564	Ub-specific processing proteases	no				GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	Reactome curated annotation of cysteine-type deubiquitinase activity, the core catalytic molecular function of USP25.
human	USP25	genes/human/USP25/USP25-ai-review.yaml	USP25	Q9UHP3	NCBITaxon:9606	Homo sapiens	41	R-HSA-5696564	Ub-specific processing proteases	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curated cytosolic localization, consistent with the experimentally established cytoplasmic/cytosolic localization of USP25.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	35	R-HSA-4641236	USP8 deubiquitinates FZD to potentiate WNT signaling	yes	reactome/R-HSA-4641236.md	USP8 deubiquitinates FZD to potentiate WNT signaling	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	USP8 is a bona fide ubiquitin-specific cysteine deubiquitinase, including activity on K48- and K63-linked ubiquitin chains where tested.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	36	R-HSA-8875443	USP8 deubiquitinates LRIG1	yes	reactome/R-HSA-8875443.md	USP8 deubiquitinates LRIG1	Homo sapiens	GO:0004843	cysteine-type deubiquitinase activity	TAS	enables	MF	false		ACCEPT	USP8 is a bona fide ubiquitin-specific cysteine deubiquitinase, including activity on K48- and K63-linked ubiquitin chains where tested.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	58	R-HSA-1358791	Phosphorylation of USP8 by P-AKT	yes	reactome/R-HSA-1358791.md	Phosphorylation of USP8 by P-AKT	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	59	R-HSA-1358795	Deubiquitination of RNF41 by P-USP8	yes	reactome/R-HSA-1358795.md	Deubiquitination of RNF41 by P-USP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	60	R-HSA-1358797	Ubiquitinated RNF41 binds P-USP8	yes	reactome/R-HSA-1358797.md	Ubiquitinated RNF41 binds P-USP8	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	61	R-HSA-4641236	USP8 deubiquitinates FZD to potentiate WNT signaling	yes	reactome/R-HSA-4641236.md	USP8 deubiquitinates FZD to potentiate WNT signaling	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	62	R-HSA-5690196	USP8 deubiquitinates RNF128	yes	reactome/R-HSA-5690196.md	USP8 deubiquitinates RNF128	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	63	R-HSA-6782628	USP8 deubiquitinates STAM2:HGS	yes	reactome/R-HSA-6782628.md	USP8 deubiquitinates STAM2:HGS	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	USP8	genes/human/USP8/USP8-ai-review.yaml	USP8	P40818	NCBITaxon:9606	Homo sapiens	64	R-HSA-8875443	USP8 deubiquitinates LRIG1	yes	reactome/R-HSA-8875443.md	USP8 deubiquitinates LRIG1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol/cytoplasm localization is consistent with USP8 function as a cytosolic enzyme recruited to endosomal membranes and other cytoplasmic structures.
human	UVRAG	genes/human/UVRAG/UVRAG-ai-review.yaml	UVRAG	Q9P2Y5	NCBITaxon:9606	Homo sapiens	49	R-HSA-9730505	SARS-CoV-2 3a binds to UVRAG	yes	reactome/R-HSA-9730505.md	SARS-CoV-2 3a binds to UVRAG	Homo sapiens	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	ERGIC membrane is a virus-event-specific Reactome localization and is too specific for general UVRAG biology.
human	VAPA	genes/human/VAPA/VAPA-ai-review.yaml	VAPA	Q9P0L0	NCBITaxon:9606	Homo sapiens	116	R-HSA-429730	PPM1L dephosphorylates multiphospho-CERT1-2	yes	reactome/R-HSA-429730.md	PPM1L dephosphorylates multiphospho-CERT1-2	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane anchoring and contact-site residence are integral to VAPA function.
human	VAPA	genes/human/VAPA/VAPA-ai-review.yaml	VAPA	Q9P0L0	NCBITaxon:9606	Homo sapiens	117	R-HSA-9956909	CERT1-2 transfers CERA from the ER membrane to the Golgi membrane	yes	reactome/R-HSA-9956909.md	CERT1-2 transfers CERA from the ER membrane to the Golgi membrane	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane anchoring and contact-site residence are integral to VAPA function.
human	VAPA	genes/human/VAPA/VAPA-ai-review.yaml	VAPA	Q9P0L0	NCBITaxon:9606	Homo sapiens	118	R-HSA-9609921	SGTA binds Tail-anchored protein	yes	reactome/R-HSA-9609921.md	SGTA binds Tail-anchored protein	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the ancillary localization without replacing the principal ER-membrane topology.
human	VAPA	genes/human/VAPA/VAPA-ai-review.yaml	VAPA	Q9P0L0	NCBITaxon:9606	Homo sapiens	122	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the reported peripheral membrane/junctional/vesicular pool.
human	VAPA	genes/human/VAPA/VAPA-ai-review.yaml	VAPA	Q9P0L0	NCBITaxon:9606	Homo sapiens	151	R-HSA-6798739	Exocytosis of azurophil granule membrane proteins	yes	reactome/R-HSA-6798739.md	Exocytosis of azurophil granule membrane proteins	Homo sapiens	GO:0035577	azurophil granule membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Retain the ancillary localization without replacing the principal ER-membrane topology.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	161	R-HSA-8943080	TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11	yes	reactome/R-HSA-8943080.md	TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	VCP at ER membrane in CMV US11-mediated MHC class I degradation pathway.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	162	R-HSA-8943083	US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP	yes	reactome/R-HSA-8943083.md	US11:HLA binds DERL1:TMEM129:Ub:UBE2J2,UBE2K:VIMP:VCP	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	VCP in DERL1:TMEM129 ERAD complex at ER membrane.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	164	R-HSA-8932276	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP	yes	reactome/R-HSA-8932276.md	VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for VCPKMT methylation.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	165	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP found in secretory granule lumen contents released extracellularly. This is from neutrophil degranulation pathway.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	166	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP in azurophil granule contents released extracellularly.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	167	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP in ficolin-1-rich granule contents released extracellularly.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	168	R-HSA-6798748	Exocytosis of secretory granule lumen proteins	yes	reactome/R-HSA-6798748.md	Exocytosis of secretory granule lumen proteins	Homo sapiens	GO:0034774	secretory granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP found in secretory granule lumen. Neutrophil granule content.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	169	R-HSA-6798751	Exocytosis of azurophil granule lumen proteins	yes	reactome/R-HSA-6798751.md	Exocytosis of azurophil granule lumen proteins	Homo sapiens	GO:0035578	azurophil granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP in azurophil granule lumen. Neutrophil granule content.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	170	R-HSA-6800434	Exocytosis of ficolin-rich granule lumen proteins	yes	reactome/R-HSA-6800434.md	Exocytosis of ficolin-rich granule lumen proteins	Homo sapiens	GO:1904813	ficolin-1-rich granule lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	VCP in ficolin-1-rich granule lumen. Neutrophil granule content.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	200	R-HSA-5654985	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH	yes	reactome/R-HSA-5654985.md	SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	VCP in nucleoplasm for SPRTN-mediated POLH release from PCNA.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	201	R-HSA-5654989	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA	yes	reactome/R-HSA-5654989.md	SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	VCP in nucleoplasm for SPRTN-VCP-mediated POLH release.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	202	R-HSA-5688834	ATXN3 binds VCP	yes	reactome/R-HSA-5688834.md	ATXN3 binds VCP	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	VCP in nucleoplasm for ATXN3 binding.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	216	R-HSA-5324632	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	yes	reactome/R-HSA-5324632.md	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol from HSF1/HSP90 dissociation pathway.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	217	R-HSA-5362412	SYVN1 ubiquitinates Hh C-terminal fragments	yes	reactome/R-HSA-5362412.md	SYVN1 ubiquitinates Hh C-terminal fragments	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for Hh C-terminal fragment ubiquitination.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	218	R-HSA-5362441	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	yes	reactome/R-HSA-5362441.md	C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for Hh fragment recruitment to ERAD machinery.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	219	R-HSA-5362459	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	yes	reactome/R-HSA-5362459.md	VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP-catalyzed ATP hydrolysis promotes Hh-C translocation to cytosol.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	220	R-HSA-5387386	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	yes	reactome/R-HSA-5387386.md	Hh processing variants are recruited to SEL1:SYVN at the ER membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for Hh variant processing.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	221	R-HSA-5387389	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	yes	reactome/R-HSA-5387389.md	Hh processing variants are translocated to the cytosol in a VCP-dependent manner	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for Hh variant translocation.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	222	R-HSA-5483238	Hh processing variants are ubiquitinated	yes	reactome/R-HSA-5483238.md	Hh processing variants are ubiquitinated	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for Hh variant ubiquitination.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	223	R-HSA-6781953	YOD1 binds VCP	yes	reactome/R-HSA-6781953.md	YOD1 binds VCP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for YOD1 binding.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	224	R-HSA-8850594	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins	yes	reactome/R-HSA-8850594.md	Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for deglycosylation complex.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	225	R-HSA-8866542	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	yes	reactome/R-HSA-8866542.md	VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR ERAD.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	226	R-HSA-8866546	RNF5 and RNF185 ubiquitinate misfolded CFTR	yes	reactome/R-HSA-8866546.md	RNF5 and RNF185 ubiquitinate misfolded CFTR	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR ubiquitination.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	227	R-HSA-8866551	CFTR binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866551.md	CFTR binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR ERAD complex binding.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	228	R-HSA-8866854	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	yes	reactome/R-HSA-8866854.md	VCP-catalyzed ATP hydrolysis promotes the translocation of CFTR F508del into the cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR F508del ERAD.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	229	R-HSA-8866856	RNF5 and RNF185 ubiquitinate CFTR F508del	yes	reactome/R-HSA-8866856.md	RNF5 and RNF185 ubiquitinate CFTR F508del	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR F508del ubiquitination.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	230	R-HSA-8866857	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	yes	reactome/R-HSA-8866857.md	CFTR F508del binds components of the ERAD machinery for ubiquitination and degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CFTR F508del ERAD complex.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	231	R-HSA-9755507	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	yes	reactome/R-HSA-9755507.md	UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for UBXN7-NFE2L2/NRF2 CRL3 complex interaction.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	232	R-HSA-9758088	UBXN7 binds VCP hexamer:UBF1:NPLOC4	yes	reactome/R-HSA-9758088.md	UBXN7 binds VCP hexamer:UBF1:NPLOC4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for UBXN7 binding.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	233	R-HSA-9758090	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	yes	reactome/R-HSA-9758090.md	Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for ubiquitinated NFE2L2 extraction.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	234	R-HSA-9931264	Active transport of ubiquitinated CD274 from ER to cytosol	yes	reactome/R-HSA-9931264.md	Active transport of ubiquitinated CD274 from ER to cytosol	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CD274/PD-L1 ERAD.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	235	R-HSA-9931298	Ubiquitination of CD274 by ERAD complex	yes	reactome/R-HSA-9931298.md	Ubiquitination of CD274 by ERAD complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CD274 ubiquitination by ERAD complex.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	236	R-HSA-9931313	p-S195-CD274 binds ERAD complex	yes	reactome/R-HSA-9931313.md	p-S195-CD274 binds ERAD complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for CD274 ERAD complex binding.
human	VCP	genes/human/VCP/VCP-ai-review.yaml	VCP	P55072	NCBITaxon:9606	Homo sapiens	237	R-HSA-9948427	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	yes	reactome/R-HSA-9948427.md	ANKZF1 cleaves the peptidyl-tRNA in VCP hexamer:LTN1:NEMF:60S ribosome subunit:peptidyl-tRNA with K48polyUb-nascent peptide	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	VCP in cytosol for ANKZF1-mediated ribosome QC.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	50	R-HSA-1235037	Expression of VEGFA	yes	reactome/R-HSA-1235037.md	Expression of VEGFA	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFA expression. VEGFA is secreted to the extracellular region.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	51	R-HSA-194310	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization	yes	reactome/R-HSA-194310.md	VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGF-A,C,D binding to VEGFR2.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	52	R-HSA-194311	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization	yes	reactome/R-HSA-194311.md	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFA,B,PLGF binding to VEGFR1.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	53	R-HSA-195378	Homodimerization of VEGF proteins	yes	reactome/R-HSA-195378.md	Homodimerization of VEGF proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for homodimerization of VEGF proteins.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	54	R-HSA-4420083	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2	yes	reactome/R-HSA-4420083.md	PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PTK2 recruitment to VEGFR2 signaling complex.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	55	R-HSA-4420099	p-6Y-VEGFR2 binds SHB	yes	reactome/R-HSA-4420099.md	p-6Y-VEGFR2 binds SHB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFR2-SHB binding.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	56	R-HSA-4420107	p-6Y-VEGFR2 binds SHC-transforming protein 2	yes	reactome/R-HSA-4420107.md	p-6Y-VEGFR2 binds SHC-transforming protein 2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFR2-SHC2 binding.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	57	R-HSA-4420117	VEGFR2 autophosphorylates	yes	reactome/R-HSA-4420117.md	VEGFR2 autophosphorylates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFR2 autophosphorylation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	58	R-HSA-4420121	SFKs phosphorylate PLCG1	yes	reactome/R-HSA-4420121.md	SFKs phosphorylate PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SFK phosphorylation of PLCgamma1.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	59	R-HSA-4420128	SRC-1 phosphorylates SHB	yes	reactome/R-HSA-4420128.md	SRC-1 phosphorylates SHB	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SRC-1 phosphorylation of SHB.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	60	R-HSA-4420140	SRC1-1 binds SH2D2A and is recruited to VEGFR2	yes	reactome/R-HSA-4420140.md	SRC1-1 binds SH2D2A and is recruited to VEGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for SRC-1 recruitment to VEGFR2.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	61	R-HSA-4420143	p-6Y-VEGFR2 binds SH2D2A	yes	reactome/R-HSA-4420143.md	p-6Y-VEGFR2 binds SH2D2A	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFR2-SH2D2A binding.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	62	R-HSA-4420153	p-6Y-VEGFR2 binds PLCG1	yes	reactome/R-HSA-4420153.md	p-6Y-VEGFR2 binds PLCG1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGFR2-PLCgamma1 binding.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	63	R-HSA-4420202	PLCG1 disassociates from VEGFR2 and translocate to PM	yes	reactome/R-HSA-4420202.md	PLCG1 disassociates from VEGFR2 and translocate to PM	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for PLCgamma1 translocation to plasma membrane.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	64	R-HSA-4420206	Phosphorylation of SRC-1	yes	reactome/R-HSA-4420206.md	Phosphorylation of SRC-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. VEGFA is secreted extracellularly.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	65	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for platelet degranulation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	66	R-HSA-5218640	SRC-1 phosphorylates p-Y397-PTK2	yes	reactome/R-HSA-5218640.md	SRC-1 phosphorylates p-Y397-PTK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NRP1-VEGF binding.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	67	R-HSA-5218642	PTK2 autophosphorylates	yes	reactome/R-HSA-5218642.md	PTK2 autophosphorylates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for NRP1-VEGFR signaling complex.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	68	R-HSA-5218643	HSP90AA1 binds p-6Y-VEGFR2	yes	reactome/R-HSA-5218643.md	HSP90AA1 binds p-6Y-VEGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for VEGF signaling.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	69	R-HSA-5218645	SRC-1 binds p-Y397-PTK2	yes	reactome/R-HSA-5218645.md	SRC-1 binds p-Y397-PTK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	70	R-HSA-5218804	p38 MAPK activation by VEGFR	yes	reactome/R-HSA-5218804.md	p38 MAPK activation by VEGFR	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	71	R-HSA-5218806	FYN autophosphorylates	yes	reactome/R-HSA-5218806.md	FYN autophosphorylates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	72	R-HSA-5218809	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118	yes	reactome/R-HSA-5218809.md	PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	73	R-HSA-5218811	DOCK180:ELMO binds CRK	yes	reactome/R-HSA-5218811.md	DOCK180:ELMO binds CRK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	74	R-HSA-5218812	FYN phosphorylates PAK2	yes	reactome/R-HSA-5218812.md	FYN phosphorylates PAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	75	R-HSA-5218814	PAK2 autophorylates	yes	reactome/R-HSA-5218814.md	PAK2 autophorylates	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	76	R-HSA-5218815	p-6Y-VEGFR2 binds NCK	yes	reactome/R-HSA-5218815.md	p-6Y-VEGFR2 binds NCK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	77	R-HSA-5218818	Integrin alphaVbeta3 binds p-6Y-VEGFR2	yes	reactome/R-HSA-5218818.md	Integrin alphaVbeta3 binds p-6Y-VEGFR2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	78	R-HSA-5218819	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	yes	reactome/R-HSA-5218819.md	VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	79	R-HSA-5218820	Src kinases phosphorylate VAV	yes	reactome/R-HSA-5218820.md	Src kinases phosphorylate VAV	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	80	R-HSA-5218822	CRK binds BCAR1 and or PXN	yes	reactome/R-HSA-5218822.md	CRK binds BCAR1 and or PXN	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	81	R-HSA-5218824	p-6Y-VEGFR2 binds FYN	yes	reactome/R-HSA-5218824.md	p-6Y-VEGFR2 binds FYN	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	82	R-HSA-5218826	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732	yes	reactome/R-HSA-5218826.md	Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	83	R-HSA-5218830	SRC-1 phosphorylates PTK2-beta	yes	reactome/R-HSA-5218830.md	SRC-1 phosphorylates PTK2-beta	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	84	R-HSA-5218832	CDC42:GTP binds PAK2	yes	reactome/R-HSA-5218832.md	CDC42:GTP binds PAK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	85	R-HSA-5218836	PTK2beta binds alphaVbeta3	yes	reactome/R-HSA-5218836.md	PTK2beta binds alphaVbeta3	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	86	R-HSA-5218838	PXN binds p-6Y,S732-PTK2	yes	reactome/R-HSA-5218838.md	PXN binds p-6Y,S732-PTK2	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	87	R-HSA-5218839	DOCK180:ELMO exchanges GTP for GDP, activating RAC1	yes	reactome/R-HSA-5218839.md	DOCK180:ELMO exchanges GTP for GDP, activating RAC1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	88	R-HSA-5218847	PAK2 binds NCK	yes	reactome/R-HSA-5218847.md	PAK2 binds NCK	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	89	R-HSA-5218851	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407	yes	reactome/R-HSA-5218851.md	p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	90	R-HSA-5218854	p-Y420-FYN is phosphorylated on S21	yes	reactome/R-HSA-5218854.md	p-Y420-FYN is phosphorylated on S21	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	91	R-HSA-5357429	AXL autophosphorylates on Y779 and Y821	yes	reactome/R-HSA-5357429.md	AXL autophosphorylates on Y779 and Y821	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	92	R-HSA-5357432	AXL binds SRC-1	yes	reactome/R-HSA-5357432.md	AXL binds SRC-1	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	93	R-HSA-5357479	p-AXL binds PI3K	yes	reactome/R-HSA-5357479.md	p-AXL binds PI3K	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	94	R-HSA-6789615	Expression of STAT3-upregulated extracellular proteins	yes	reactome/R-HSA-6789615.md	Expression of STAT3-upregulated extracellular proteins	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	95	R-HSA-8864936	VEGFA gene expression is inhibited by the TFAP2A homodimer	yes	reactome/R-HSA-8864936.md	VEGFA gene expression is inhibited by the TFAP2A homodimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	96	R-HSA-9679477	VEGFA-165 dimer binds VEGFA inhibitors	yes	reactome/R-HSA-9679477.md	VEGFA-165 dimer binds VEGFA inhibitors	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	97	R-HSA-9691215	VEGFA-165 dimer binds VEGFR2 dimer	yes	reactome/R-HSA-9691215.md	VEGFA-165 dimer binds VEGFR2 dimer	Homo sapiens	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
human	VEGFA	genes/human/VEGFA/VEGFA-ai-review.yaml	VEGFA	P15692	NCBITaxon:9606	Homo sapiens	98	R-HSA-481007	Exocytosis of platelet alpha granule contents	yes	reactome/R-HSA-481007.md	Exocytosis of platelet alpha granule contents	Homo sapiens	GO:0031093	platelet alpha granule lumen	TAS	located_in	CC	false		ACCEPT	VEGFA is stored in platelet alpha granules and released during platelet degranulation. This contributes to wound healing and vascular repair.
human	VPS28	genes/human/VPS28/VPS28-ai-review.yaml	VPS28	Q9UK41	NCBITaxon:9606	Homo sapiens	56	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS28/ESCRT-I function.
human	VPS28	genes/human/VPS28/VPS28-ai-review.yaml	VPS28	Q9UK41	NCBITaxon:9606	Homo sapiens	57	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS28/ESCRT-I function.
human	VPS28	genes/human/VPS28/VPS28-ai-review.yaml	VPS28	Q9UK41	NCBITaxon:9606	Homo sapiens	58	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS28/ESCRT-I function.
human	VPS28	genes/human/VPS28/VPS28-ai-review.yaml	VPS28	Q9UK41	NCBITaxon:9606	Homo sapiens	59	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS28/ESCRT-I function.
human	VPS28	genes/human/VPS28/VPS28-ai-review.yaml	VPS28	Q9UK41	NCBITaxon:9606	Homo sapiens	60	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS28/ESCRT-I function.
human	VPS37A	genes/human/VPS37A/VPS37A-ai-review.yaml	VPS37A	Q8NEZ2	NCBITaxon:9606	Homo sapiens	32	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37A/ESCRT-I function.
human	VPS37A	genes/human/VPS37A/VPS37A-ai-review.yaml	VPS37A	Q8NEZ2	NCBITaxon:9606	Homo sapiens	33	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37A/ESCRT-I function.
human	VPS37A	genes/human/VPS37A/VPS37A-ai-review.yaml	VPS37A	Q8NEZ2	NCBITaxon:9606	Homo sapiens	34	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37A/ESCRT-I function.
human	VPS37A	genes/human/VPS37A/VPS37A-ai-review.yaml	VPS37A	Q8NEZ2	NCBITaxon:9606	Homo sapiens	35	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37A/ESCRT-I function.
human	VPS37A	genes/human/VPS37A/VPS37A-ai-review.yaml	VPS37A	Q8NEZ2	NCBITaxon:9606	Homo sapiens	36	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37A/ESCRT-I function.
human	VPS37B	genes/human/VPS37B/VPS37B-ai-review.yaml	VPS37B	Q9H9H4	NCBITaxon:9606	Homo sapiens	44	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
human	VPS37B	genes/human/VPS37B/VPS37B-ai-review.yaml	VPS37B	Q9H9H4	NCBITaxon:9606	Homo sapiens	45	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
human	VPS37B	genes/human/VPS37B/VPS37B-ai-review.yaml	VPS37B	Q9H9H4	NCBITaxon:9606	Homo sapiens	46	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
human	VPS37B	genes/human/VPS37B/VPS37B-ai-review.yaml	VPS37B	Q9H9H4	NCBITaxon:9606	Homo sapiens	47	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
human	VPS37B	genes/human/VPS37B/VPS37B-ai-review.yaml	VPS37B	Q9H9H4	NCBITaxon:9606	Homo sapiens	48	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37B/ESCRT-I function.
human	VPS37C	genes/human/VPS37C/VPS37C-ai-review.yaml	VPS37C	A5D8V6	NCBITaxon:9606	Homo sapiens	33	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37C/ESCRT-I function.
human	VPS37C	genes/human/VPS37C/VPS37C-ai-review.yaml	VPS37C	A5D8V6	NCBITaxon:9606	Homo sapiens	34	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37C/ESCRT-I function.
human	VPS37C	genes/human/VPS37C/VPS37C-ai-review.yaml	VPS37C	A5D8V6	NCBITaxon:9606	Homo sapiens	35	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37C/ESCRT-I function.
human	VPS37C	genes/human/VPS37C/VPS37C-ai-review.yaml	VPS37C	A5D8V6	NCBITaxon:9606	Homo sapiens	36	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37C/ESCRT-I function.
human	VPS37C	genes/human/VPS37C/VPS37C-ai-review.yaml	VPS37C	A5D8V6	NCBITaxon:9606	Homo sapiens	37	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37C/ESCRT-I function.
human	VPS37D	genes/human/VPS37D/VPS37D-ai-review.yaml	VPS37D	Q86XT2	NCBITaxon:9606	Homo sapiens	22	R-HSA-184269	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	yes	reactome/R-HSA-184269.md	Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37D/ESCRT-I function.
human	VPS37D	genes/human/VPS37D/VPS37D-ai-review.yaml	VPS37D	Q86XT2	NCBITaxon:9606	Homo sapiens	23	R-HSA-3149434	Transport of GAG to the Plasma Membrane	yes	reactome/R-HSA-3149434.md	Transport of GAG to the Plasma Membrane	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37D/ESCRT-I function.
human	VPS37D	genes/human/VPS37D/VPS37D-ai-review.yaml	VPS37D	Q86XT2	NCBITaxon:9606	Homo sapiens	24	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37D/ESCRT-I function.
human	VPS37D	genes/human/VPS37D/VPS37D-ai-review.yaml	VPS37D	Q86XT2	NCBITaxon:9606	Homo sapiens	25	R-HSA-917696	Cargo Sequestration	yes	reactome/R-HSA-917696.md	Cargo Sequestration	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37D/ESCRT-I function.
human	VPS37D	genes/human/VPS37D/VPS37D-ai-review.yaml	VPS37D	Q86XT2	NCBITaxon:9606	Homo sapiens	26	R-HSA-917730	Cargo Recognition And Sorting	yes	reactome/R-HSA-917730.md	Cargo Recognition And Sorting	Homo sapiens	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	endosome membrane localization is supported and relevant to VPS37D/ESCRT-I function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	57	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	58	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	59	R-HSA-9610942	HCMV Formation of Final Envelopment Complex	yes	reactome/R-HSA-9610942.md	HCMV Formation of Final Envelopment Complex	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	60	R-HSA-9610954	HCMV Final Envelopment	yes	reactome/R-HSA-9610954.md	HCMV Final Envelopment	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	61	R-HSA-9668389	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	yes	reactome/R-HSA-9668389.md	VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	62	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase that is recruited to endosomal/vacuolar membranes during ESCRT function.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	66	R-HSA-9668415	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	yes	reactome/R-HSA-9668415.md	VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope	Homo sapiens	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	Core VPS4A function: ATP-driven recognition, remodeling, and disassembly of ESCRT-III/protein assemblies.
human	VPS4A	genes/human/VPS4A/VPS4A-ai-review.yaml	VPS4A	Q9UN37	NCBITaxon:9606	Homo sapiens	67	R-HSA-2995410	Nuclear Envelope (NE) Reassembly	yes	reactome/R-HSA-2995410.md	Nuclear Envelope (NE) Reassembly	Homo sapiens	GO:0007084	mitotic nuclear membrane reassembly	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	Supported nuclear-envelope/nucleus-organization ESCRT context, but not the primary VPS4A molecular role.
human	VPS4B	genes/human/VPS4B/VPS4B-ai-review.yaml	VPS4B	O75351	NCBITaxon:9606	Homo sapiens	82	R-HSA-3159232	Recruitment Of HIV Virion Budding Machinery	yes	reactome/R-HSA-3159232.md	Recruitment Of HIV Virion Budding Machinery	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase recruited to endosomal/late-endosomal membranes during ESCRT function.
human	VPS4B	genes/human/VPS4B/VPS4B-ai-review.yaml	VPS4B	O75351	NCBITaxon:9606	Homo sapiens	83	R-HSA-917693	ESCRT Disassembly	yes	reactome/R-HSA-917693.md	ESCRT Disassembly	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported localization for a cytosolic AAA ATPase recruited to endosomal/late-endosomal membranes during ESCRT function.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	28	R-HSA-6811431	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	yes	reactome/R-HSA-6811431.md	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	29	R-HSA-6814671	Fusion of late-endosome derived vesicles at the TGN	yes	reactome/R-HSA-6814671.md	Fusion of late-endosome derived vesicles at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	30	R-HSA-6814674	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	yes	reactome/R-HSA-6814674.md	Tethering of late endosome-derived vesicles by GARP, STX10:ST16:VTI1A and Golgins	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	31	R-HSA-6814676	SNAPs and NSF hexamer bind cis-SNARE at the TGN	yes	reactome/R-HSA-6814676.md	SNAPs and NSF hexamer bind cis-SNARE at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	32	R-HSA-6814678	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN	yes	reactome/R-HSA-6814678.md	ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	33	R-HSA-6814682	Fusion of early-endosome derived vesicles at the TGN	yes	reactome/R-HSA-6814682.md	Fusion of early-endosome derived vesicles at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	34	R-HSA-6814683	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN	yes	reactome/R-HSA-6814683.md	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	35	R-HSA-6814684	cis-SNARE binds SNAPs and NSF hexamer at the TGN	yes	reactome/R-HSA-6814684.md	cis-SNARE binds SNAPs and NSF hexamer at the TGN	Homo sapiens	GO:0032588	trans-Golgi network membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: trans-Golgi network membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	36	R-HSA-6811431	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	yes	reactome/R-HSA-6811431.md	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: Golgi membrane.
human	VTI1A	genes/human/VTI1A/VTI1A-ai-review.yaml	VTI1A	Q96AJ9	NCBITaxon:9606	Homo sapiens	37	R-HSA-6811433	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane	yes	reactome/R-HSA-6811433.md	The COG tethering complex interacts with numerous SNAREs at the Golgi membrane	Homo sapiens	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Supported Golgi/TGN location for VTI1A: Golgi membrane.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	1	R-HSA-69275	G2/M Transition	yes	reactome/R-HSA-69275.md	G2/M Transition	Homo sapiens	GO:0000086	G2/M transition of mitotic cell cycle	TAS	involved_in	BP	false		ACCEPT	WEE1 restrains entry into mitosis.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	11	R-HSA-170070	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	yes	reactome/R-HSA-170070.md	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	WEE1 directly phosphorylates CDK tyrosine.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	12	R-HSA-170156	WEE1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170156.md	WEE1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	WEE1 directly phosphorylates CDK tyrosine.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	13	R-HSA-174164	Phosphorylation of Cyclin A:Cdk2 at Tyr 15	yes	reactome/R-HSA-174164.md	Phosphorylation of Cyclin A:Cdk2 at Tyr 15	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	WEE1 directly phosphorylates CDK tyrosine.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	14	R-HSA-69195	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	yes	reactome/R-HSA-69195.md	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	WEE1 directly phosphorylates CDK tyrosine.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	32	R-HSA-156699	Inactivation of Wee1 kinase	yes	reactome/R-HSA-156699.md	Inactivation of Wee1 kinase	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	33	R-HSA-170070	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	yes	reactome/R-HSA-170070.md	Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	34	R-HSA-170156	WEE1 phosphorylates CCNA:CDK1	yes	reactome/R-HSA-170156.md	WEE1 phosphorylates CCNA:CDK1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	35	R-HSA-174164	Phosphorylation of Cyclin A:Cdk2 at Tyr 15	yes	reactome/R-HSA-174164.md	Phosphorylation of Cyclin A:Cdk2 at Tyr 15	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	36	R-HSA-69195	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	yes	reactome/R-HSA-69195.md	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	37	R-HSA-9929535	CCNA:CDK1 phosphorylates WEE1	yes	reactome/R-HSA-9929535.md	CCNA:CDK1 phosphorylates WEE1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	WEE1 performs its checkpoint role in the nucleus.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	45	R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry	yes	reactome/R-HSA-69656.md	Cyclin A:Cdk2-associated events at S phase entry	Homo sapiens	GO:0045740	positive regulation of DNA replication	TAS	involved_in	BP	false		UNDECIDED	The positive DNA-replication regulation assignment needs reaction-context tracing.
human	WEE1	genes/human/WEE1/WEE1-ai-review.yaml	WEE1	P30291	NCBITaxon:9606	Homo sapiens	46	R-HSA-69195	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	yes	reactome/R-HSA-69195.md	Phosphorylation of Cyclin E:CDK2 complexes by WEE1	Homo sapiens	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	TAS	involved_in	BP	false		KEEP_AS_NON_CORE	WEE1 also restrains cell-cycle CDK activity outside mitotic entry.
human	WFS1	genes/human/WFS1/WFS1-ai-review.yaml	WFS1	O76024	NCBITaxon:9606	Homo sapiens	52	R-HSA-8952289	FAM20C phosphorylates FAM20C substrates	yes	reactome/R-HSA-8952289.md	FAM20C phosphorylates FAM20C substrates	Homo sapiens	GO:0005788	endoplasmic reticulum lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome pathway annotation for FAM20C phosphorylation substrates. WFS1 is phosphorylated in the ER lumen.
human	WFS1	genes/human/WFS1/WFS1-ai-review.yaml	WFS1	O76024	NCBITaxon:9606	Homo sapiens	58	R-HSA-1791169	Expression of WFS1	yes	reactome/R-HSA-1791169.md	Expression of WFS1	Homo sapiens	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation for WFS1 expression. Consistent with other evidence.
human	WIPF1	genes/human/WIPF1/WIPF1-ai-review.yaml	WIPF1	O43516	NCBITaxon:9606	Homo sapiens	40	R-HSA-2029466	WASPs WAVE G-actin ARP2/3 binds F-actin	yes	reactome/R-HSA-2029466.md	(WASPs, WAVE):G-actin:ARP2/3 binds F-actin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	WIP is present in cytosol as part of WASP/WAVE-ARP2/3 complexes that bind F-actin.
human	WIPF1	genes/human/WIPF1/WIPF1-ai-review.yaml	WIPF1	O43516	NCBITaxon:9606	Homo sapiens	41	R-HSA-2197690	Detachment of WASP/WAVE	yes	reactome/R-HSA-2197690.md	Detachment of WASP/WAVE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway for WASP/WAVE detachment.
human	WIPF1	genes/human/WIPF1/WIPF1-ai-review.yaml	WIPF1	O43516	NCBITaxon:9606	Homo sapiens	42	R-HSA-2197691	WIP binds WASP N-WASP activating them	yes	reactome/R-HSA-2197691.md	WIP binds WASP,N-WASP, activating them	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway for WIP binding and activating WASP/N-WASP.
human	WIPF1	genes/human/WIPF1/WIPF1-ai-review.yaml	WIPF1	O43516	NCBITaxon:9606	Homo sapiens	43	R-HSA-2197698	Src phosphorylate WASP N-WASP	yes	reactome/R-HSA-2197698.md	Src phosphorylate WASP,N-WASP	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway for Src phosphorylation of WASP/N-WASP.
human	WIPF1	genes/human/WIPF1/WIPF1-ai-review.yaml	WIPF1	O43516	NCBITaxon:9606	Homo sapiens	44	R-HSA-9013157	CDC42 GTPase cycle	yes	reactome/R-HSA-9013157.md	CDC42 binds effectors at the plasma membrane	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	CDC42 GTPase cycle pathway involving WIP-WASP complex.
human	WIPI2	genes/human/WIPI2/WIPI2-ai-review.yaml	WIPI2	Q9Y4P8	NCBITaxon:9606	Homo sapiens	33	R-HSA-5676229	WIPIs bind PI3P	yes	reactome/R-HSA-5676229.md	WIPIs bind PI3P	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	WIPI2 cycles between the cytosol and PI3P-containing autophagic membranes.
human	WIPI2	genes/human/WIPI2/WIPI2-ai-review.yaml	WIPI2	Q9Y4P8	NCBITaxon:9606	Homo sapiens	34	R-HSA-5678490	ATG16L1 complex transfers LC3 from ATG3 to PE	yes	reactome/R-HSA-5678490.md	ATG16L1 complex transfers LC3 from ATG3 to PE	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	WIPI2 cycles between the cytosol and PI3P-containing autophagic membranes.
human	WIPI2	genes/human/WIPI2/WIPI2-ai-review.yaml	WIPI2	Q9Y4P8	NCBITaxon:9606	Homo sapiens	35	R-HSA-5679255	WIPI2 binds ATG12:ATG5:ATG16L	yes	reactome/R-HSA-5679255.md	WIPI2 binds ATG12:ATG5:ATG16L	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	WIPI2 cycles between the cytosol and PI3P-containing autophagic membranes.
human	WT1	genes/human/WT1/WT1-ai-review.yaml	WT1	P19544	NCBITaxon:9606	Homo sapiens	130	R-HSA-9767700	Reactome pathway annotation	yes	reactome/R-HSA-9767700.md	WT1 binds CDH1 gene promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation. WT1 binds CDH1 gene promoter.
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	35	R-HSA-74247	XDH oxidizes hypoxanthine to form xanthine	yes	reactome/R-HSA-74247.md	XDH oxidizes hypoxanthine to form xanthine	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization associated with the reaction ""XDH oxidizes hypoxanthine to form xanthine"". Concordant with experimental data."
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	36	R-HSA-74258	XDH oxidizes xanthine to form urate	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization associated with the reaction ""XDH oxidizes xanthine to form urate"". Concordant with experimental data."
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	37	R-HSA-8851044	BTN1A1 binds xanthine oxidoreductase (XDH)	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization associated with ""BTN1A1 binds xanthine oxidoreductase (XDH)"". Concordant with the cytosolic distribution."
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	38	R-HSA-9727347	XDH dehydrogenates hypoxanthine to form xanthine	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization for the reaction ""XDH dehydrogenates hypoxanthine to form xanthine"". Concordant with experimental data."
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	39	R-HSA-9727349	XDH dehydrogenates xanthine to form urate	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization for the reaction ""XDH dehydrogenates xanthine to form urate"". Concordant with experimental data."
human	XDH	genes/human/XDH/XDH-ai-review.yaml	XDH	P47989	NCBITaxon:9606	Homo sapiens	40	R-HSA-9748991	XDH oxidises 6MP to 6TU	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	"Reactome-asserted cytosolic localization for the reaction ""XDH oxidises 6MP to 6TU"" (6-mercaptopurine metabolism). Concordant with the cytosolic distribution."
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	35	R-HSA-5685318	BCDX2 complex formation	yes	reactome/R-HSA-5685318.md	BCDX2 complex formation	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway (BCDX2 complex formation).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	36	R-HSA-5685341	BCDX2 complex stabilizes RAD51 filament	yes	reactome/R-HSA-5685341.md	BCDX2 complex stabilizes RAD51 filament	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome (BCDX2 stabilizes RAD51 filament).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	37	R-HSA-5685838	CX3 complex binds D-loop structures	yes	reactome/R-HSA-5685838.md	CX3 complex binds D-loop structures	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	38	R-HSA-5686410	BLM mediates dissolution of double Holliday junction	yes	reactome/R-HSA-5686410.md	BLM mediates dissolution of double Holliday junction	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	39	R-HSA-5686440	MUS81:EME1,EME2 cleaves D-loop	yes	reactome/R-HSA-5686440.md	MUS81:EME1,EME2 cleaves D-loop	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	40	R-HSA-5686469	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	yes	reactome/R-HSA-5686469.md	Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	41	R-HSA-5686483	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5686483.md	Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	42	R-HSA-5693539	Ligation of DNA and formation of Holliday structures following repair synthesis	yes	reactome/R-HSA-5693539.md	Ligation of DNA and formation of Holliday structures following repair synthesis	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	43	R-HSA-5693584	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	yes	reactome/R-HSA-5693584.md	Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	44	R-HSA-5693589	D-loop dissociation and strand annealing	yes	reactome/R-HSA-5693589.md	D-loop dissociation and strand annealing	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	45	R-HSA-5693593	D-loop extension by DNA polymerases	yes	reactome/R-HSA-5693593.md	D-loop extension by DNA polymerases	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	46	R-HSA-5693620	D-loop formation mediated by PALB2, BRCA2 and RAD51	yes	reactome/R-HSA-5693620.md	D-loop formation mediated by PALB2, BRCA2 and RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway.
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	47	R-HSA-9701199	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	yes	reactome/R-HSA-9701199.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway (defective-BRCA1 context).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	48	R-HSA-9704330	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	yes	reactome/R-HSA-9704330.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway (defective-PALB2 context).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	49	R-HSA-9704408	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	yes	reactome/R-HSA-9704408.md	Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway (defective-PALB2 context).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	50	R-HSA-9709601	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	yes	reactome/R-HSA-9709601.md	Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome HR pathway (defective-BRCA2 context).
human	XRCC2	genes/human/XRCC2/XRCC2-ai-review.yaml	XRCC2	O43543	NCBITaxon:9606	Homo sapiens	51	R-HSA-9853389	FIGNL1 binds RAD51	yes	reactome/R-HSA-9853389.md	FIGNL1 binds RAD51	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization from Reactome (FIGNL1 binds RAD51 context).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	191	R-HSA-3769391	XPO1 binds the beta-catenin:CBY complex	yes	reactome/R-HSA-3769391.md	XPO1 binds the beta-catenin:CBY complex	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	192	R-HSA-3769392	YWHAZ and XPO1 mediate the nuclear export of beta-catenin	yes	reactome/R-HSA-3769392.md	YWHAZ and XPO1 mediate the nuclear export of beta-catenin	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	193	R-HSA-3769393	YWHAZ binds p-CBY:CTNNB1	yes	reactome/R-HSA-3769393.md	YWHAZ binds p-CBY:CTNNB1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	194	R-HSA-450620	p-S193-KSRP binds 14-3-3zeta in the nucleus	yes	reactome/R-HSA-450620.md	p-S193-KSRP binds 14-3-3zeta in the nucleus	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS-supported nucleoplasmic localization, consistent with nuclear 14-3-3 zeta acting on TP53/FOXO clients; secondary to its predominant cytosolic site.
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	195	R-HSA-139899	Sequestration of BAD protein by 14-3-3	yes	reactome/R-HSA-139899.md	Sequestration of BAD protein by 14-3-3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	196	R-HSA-139906	Activation of BAD by calcineurin	yes	reactome/R-HSA-139906.md	Activation of BAD by calcineurin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	197	R-HSA-3769392	YWHAZ and XPO1 mediate the nuclear export of beta-catenin	yes	reactome/R-HSA-3769392.md	YWHAZ and XPO1 mediate the nuclear export of beta-catenin	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	198	R-HSA-430073	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress	yes	reactome/R-HSA-430073.md	GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	199	R-HSA-430076	GP1b-IX-V binds 14-3-3-zeta	yes	reactome/R-HSA-430076.md	GP1b-IX-V binds 14-3-3-zeta	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	200	R-HSA-443402	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K	yes	reactome/R-HSA-443402.md	GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	201	R-HSA-443831	14-3-3-zeta binds Raf1	yes	reactome/R-HSA-443831.md	14-3-3-zeta binds Raf1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	202	R-HSA-5632732	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4	yes	reactome/R-HSA-5632732.md	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	203	R-HSA-5632738	DDIT4 binds 14-3-3 dimer	yes	reactome/R-HSA-5632738.md	DDIT4 binds 14-3-3 dimer	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	204	R-HSA-75016	Association of p-S216-CDC25C with 14-3-3 proteins	yes	reactome/R-HSA-75016.md	Association of p-S216-CDC25C with 14-3-3 proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	205	R-HSA-912757	p-S585-IL3RB binds 14-3-3 proteins	yes	reactome/R-HSA-912757.md	p-S585-IL3RB binds 14-3-3 proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	206	R-HSA-913993	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2	yes	reactome/R-HSA-913993.md	14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	207	R-HSA-914182	14-3-3 zeta binding allows recruitment of PI3K	yes	reactome/R-HSA-914182.md	14-3-3 zeta binding allows recruitment of PI3K	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	208	R-HSA-9614423	14-3-3 proteins bind AKT-phosphorylated FOXO1	yes	reactome/R-HSA-9614423.md	14-3-3 proteins bind AKT-phosphorylated FOXO1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	209	R-HSA-9614562	14-3-3 proteins bind AKT-phosphorylated FOXO3	yes	reactome/R-HSA-9614562.md	14-3-3 proteins bind AKT-phosphorylated FOXO3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	210	R-HSA-9614564	14-3-3 proteins bind AKT-phosphorylated FOXO4	yes	reactome/R-HSA-9614564.md	14-3-3 proteins bind AKT-phosphorylated FOXO4	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	211	R-HSA-9727919	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins	yes	reactome/R-HSA-9727919.md	SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	YWHAZ	genes/human/YWHAZ/YWHAZ-ai-review.yaml	YWHAZ	P63104	NCBITaxon:9606	Homo sapiens	212	R-HSA-9729500	SARS-CoV-2 N binds to 14-3-3 proteins	yes	reactome/R-HSA-9729500.md	SARS-CoV-2 N binds to 14-3-3 proteins	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	14-3-3 zeta is predominantly cytosolic, where it binds clients and retains them in the cytoplasm; strongly supported (20 annotations, IDA/TAS).
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	39	R-HSA-1591234	ZBP1 binds cytosolic DNA	yes	reactome/R-HSA-1591234.md	ZBP1 binds cytosolic DNA	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by the Reactome ZBP1 cytosolic-DNA pathway.
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	40	R-HSA-1606327	Phosphorylation and release of IRF3	yes	reactome/R-HSA-1606327.md	Phosphorylation and release of IRF3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by a Reactome IRF3 phosphorylation event.
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	41	R-HSA-1810457	ZBP1(DAI) recruits RIP1 and RIP3	yes	reactome/R-HSA-1810457.md	ZBP1(DAI) recruits RIP1 and RIP3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by the Reactome ZBP1/RIP1/RIP3 recruitment event.
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	42	R-HSA-3249386	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1	yes	reactome/R-HSA-3249386.md	DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by a Reactome NLRP4/DTX4/TBK1 event.
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	43	R-HSA-8948703	NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1	yes	reactome/R-HSA-8948703.md	NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by a Reactome NLRP4/DTX4/TBK1 association event.
human	ZBP1	genes/human/ZBP1/ZBP1-ai-review.yaml	ZBP1	Q9H171	NCBITaxon:9606	Homo sapiens	44	R-HSA-9679819	TBK1 binds amlexanox	yes	reactome/R-HSA-9679819.md	TBK1 binds amlexanox	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localisation asserted by a Reactome TBK1 inhibitor-binding event.
human	ZNF598	genes/human/ZNF598/ZNF598-ai-review.yaml	ZNF598	Q86UK7	NCBITaxon:9606	Homo sapiens	10	R-HSA-9948299	Reactome: rescue of stalled ribosome (ZNF598)	yes	reactome/R-HSA-9948299.md	Ribosome-associated quality control	Homo sapiens	GO:0072344	rescue of stalled cytosolic ribosome	TAS	involved_in	BP	false		ACCEPT	Reactome curation of ZNF598's stalled-ribosome rescue role.
human	ZNF598	genes/human/ZNF598/ZNF598-ai-review.yaml	ZNF598	Q86UK7	NCBITaxon:9606	Homo sapiens	13	R-HSA-9948301	Reactome: ZNF598 ubiquitin transferase activity / cytosol	yes	reactome/R-HSA-9948301.md	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	Homo sapiens	GO:0004842	ubiquitin-protein transferase activity	TAS	enables	MF	false		ACCEPT	Reactome curation of ZNF598's ubiquitin-protein transferase activity, a parent of the specific ubiquitin protein ligase activity it enables.
human	ZNF598	genes/human/ZNF598/ZNF598-ai-review.yaml	ZNF598	Q86UK7	NCBITaxon:9606	Homo sapiens	14	R-HSA-9948301	Reactome: ZNF598 ubiquitin transferase activity / cytosol	yes	reactome/R-HSA-9948301.md	ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of ZNF598 cytosolic localization.
human	ZNF598	genes/human/ZNF598/ZNF598-ai-review.yaml	ZNF598	Q86UK7	NCBITaxon:9606	Homo sapiens	15	R-HSA-9948317	Reactome: ZNF598 cytosol localization	yes	reactome/R-HSA-9948317.md	ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome curation of ZNF598 cytosolic localization.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	143	R-MMU-9727502	Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex	yes	reactome/R-MMU-9727502.md	Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reflects nucleoplasmic localization (e.g. as part of nuclear complexes). A small monomeric nuclear actin pool exists and participates in nuclear processes, but this is a minor, context-dependent role, not the core cytoplasmic structural function. The falcon report focuses entirely on cytoplasmic/cytoskeletal beta-actin and provides no chromatin-remodeling evidence.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	144	R-MMU-9845305	Dnmt3a:Dnmt3l in nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd11:Dnmt3a:Dnmt3l methylates cytosine in DNA	yes	reactome/R-MMU-9845305.md	Dnmt3a:Dnmt3l in nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd11:Dnmt3a:Dnmt3l methylates cytosine in DNA	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reflects nucleoplasmic localization (e.g. as part of nuclear complexes). A small monomeric nuclear actin pool exists and participates in nuclear processes, but this is a minor, context-dependent role, not the core cytoplasmic structural function. The falcon report focuses entirely on cytoplasmic/cytoskeletal beta-actin and provides no chromatin-remodeling evidence.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	145	R-MMU-9934111	Formation of neural BAF (nBaf)	yes	reactome/R-MMU-9934111.md	Formation of neural BAF (nBaf)	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reflects nucleoplasmic localization (e.g. as part of nuclear complexes). A small monomeric nuclear actin pool exists and participates in nuclear processes, but this is a minor, context-dependent role, not the core cytoplasmic structural function. The falcon report focuses entirely on cytoplasmic/cytoskeletal beta-actin and provides no chromatin-remodeling evidence.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	161	R-MMU-2316348	RalA:GTP binds Myo1c:Calm1 and F-actin	yes	reactome/R-MMU-2316348.md	RalA:GTP binds Myo1c:Calm1 and F-actin	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic pool of monomeric (G-)actin and soluble actin complexes.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	162	R-MMU-2316351	Translocation of Glut4 Vesicle and Docking at the Plasma Membrane	yes	reactome/R-MMU-2316351.md	Translocation of Glut4 Vesicle and Docking at the Plasma Membrane	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic pool of monomeric (G-)actin and soluble actin complexes.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	163	R-MMU-9659536	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear inner hair cell	yes	reactome/R-MMU-9659536.md	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear inner hair cell	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic pool of monomeric (G-)actin and soluble actin complexes.
mouse	Actb	genes/mouse/Actb/Actb-ai-review.yaml	Actb	P60710	NCBITaxon:10090	Mus musculus	164	R-MMU-9663360	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell	yes	reactome/R-MMU-9663360.md	MET channel transports cations from the extracellular region into the cytosol of stereocilia of cochlear outer hair cell	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Cytosolic pool of monomeric (G-)actin and soluble actin complexes.
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	102	R-MMU-1445150	Akt Phosphorylates As160 (Tbc1d4)	yes	reactome/R-MMU-1445150.md	Akt Phosphorylates As160 (Tbc1d4)	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Core AKT1 serine/threonine kinase activity
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	103	R-MMU-9857656	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)	yes	reactome/R-MMU-9857656.md	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Core AKT1 serine/threonine kinase activity
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	104	R-MMU-9857664	p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)	yes	reactome/R-MMU-9857664.md	p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	Core AKT1 serine/threonine kinase activity
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	328	R-MMU-9863573	Akt1 binds phosphoinositol-3,4,5-trisphosphate	yes	reactome/R-MMU-9863573.md	Akt1 binds phosphoinositol-3,4,5-trisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	329	R-MMU-9906595	Activation of Akt1 by shear stress in osteocytes	yes	reactome/R-MMU-9906595.md	Activation of Akt1 by shear stress in osteocytes	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	343	R-MMU-162352	Phosphorylation of PDE3B by AKT-1	yes	reactome/R-MMU-162352.md	Phosphorylation of PDE3B by AKT-1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	344	R-MMU-9857656	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)	yes	reactome/R-MMU-9857656.md	Phosphorylated Akt1 phosphorylates Connexin-43 (Gja1)	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	345	R-MMU-9857664	p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)	yes	reactome/R-MMU-9857664.md	p-T308,S473-Akt1 phosphorylates Itga5 (Integrin alpha5) in Itga5:Itgb1 (Integrin alpha5:Integrin beta1)	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Akt1	genes/mouse/Akt1/Akt1-ai-review.yaml	Akt1	P31750	NCBITaxon:10090	Mus musculus	346	R-MMU-1445150	Akt Phosphorylates As160 (Tbc1d4)	yes	reactome/R-MMU-1445150.md	Akt Phosphorylates As160 (Tbc1d4)	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane localization
mouse	Brca1	genes/mouse/Brca1/Brca1-ai-review.yaml	Brca1	P48754	NCBITaxon:10090	Mus musculus	146	R-MMU-912421	Formation of Meiotic Single-stranded Invasion Complex	yes	reactome/R-MMU-912421.md	Formation of Meiotic Single-stranded Invasion Complex	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization consistent with BRCA1's soluble nuclear and chromatin-associated repair/checkpoint activities.
mouse	Brca1	genes/mouse/Brca1/Brca1-ai-review.yaml	Brca1	P48754	NCBITaxon:10090	Mus musculus	147	R-MMU-912423	Atr Phosphorylates Histone H2A.X at Unsynapsed Regions	yes	reactome/R-MMU-912423.md	Atr Phosphorylates Histone H2A.X at Unsynapsed Regions	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization consistent with BRCA1's soluble nuclear and chromatin-associated repair/checkpoint activities.
mouse	Brca1	genes/mouse/Brca1/Brca1-ai-review.yaml	Brca1	P48754	NCBITaxon:10090	Mus musculus	148	R-MMU-912431	Formation of Meiotic Heteroduplex	yes	reactome/R-MMU-912431.md	Formation of Meiotic Heteroduplex	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization consistent with BRCA1's soluble nuclear and chromatin-associated repair/checkpoint activities.
mouse	Brca1	genes/mouse/Brca1/Brca1-ai-review.yaml	Brca1	P48754	NCBITaxon:10090	Mus musculus	149	R-MMU-912449	Recruitment of Atr Kinase to Unsynapsed Regions	yes	reactome/R-MMU-912449.md	Recruitment of Atr Kinase to Unsynapsed Regions	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization consistent with BRCA1's soluble nuclear and chromatin-associated repair/checkpoint activities.
mouse	Brca1	genes/mouse/Brca1/Brca1-ai-review.yaml	Brca1	P48754	NCBITaxon:10090	Mus musculus	150	R-MMU-912468	Recruitment of Brca1 to Unsynapsed Regions	yes	reactome/R-MMU-912468.md	Recruitment of Brca1 to Unsynapsed Regions	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasmic localization consistent with BRCA1's soluble nuclear and chromatin-associated repair/checkpoint activities.
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	142	R-MMU-9005848	Active Prkaca and CaMK IV phosphorylate Mecp2 at T308	yes	reactome/R-MMU-9005848.md	Active Prkaca and CaMK IV phosphorylate Mecp2 at T308	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	143	R-MMU-9005872	Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308	yes	reactome/R-MMU-9005872.md	Active Prkaca, CAMK IV does not phosphorylate Mecp2_e2 mutant R306C at T308	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	144	R-MMU-9007015	Mecp2 is phosphorylated at S421	yes	reactome/R-MMU-9007015.md	Mecp2 is phosphorylated at S421	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasm localization
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	145	R-MMU-2025936	Calcineurin Dephosphorylates Nfatc2	yes	reactome/R-MMU-2025936.md	Calcineurin Dephosphorylates Nfatc2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	146	R-MMU-2316348	RalA:GTP binds Myo1c:Calm1 and F-actin	yes	reactome/R-MMU-2316348.md	RalA:GTP binds Myo1c:Calm1 and F-actin	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
mouse	Calm1	genes/mouse/Calm1/Calm1-ai-review.yaml	Calm1	P0DP26	NCBITaxon:10090	Mus musculus	147	R-MMU-2316351	Translocation of Glut4 Vesicle and Docking at the Plasma Membrane	yes	reactome/R-MMU-2316351.md	Translocation of Glut4 Vesicle and Docking at the Plasma Membrane	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Soluble cytosolic protein
mouse	Casp3	genes/mouse/Casp3/Casp3-ai-review.yaml	Casp3	P70677	NCBITaxon:10090	Mus musculus	159	R-MMU-418855	Caspase cleavage of Unc5h1	yes	reactome/R-MMU-418855.md	Caspase cleavage of Unc5h1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with Casp3 as an executioner caspase that cleaves protein substrates during apoptotic execution.
mouse	Casp3	genes/mouse/Casp3/Casp3-ai-review.yaml	Casp3	P70677	NCBITaxon:10090	Mus musculus	160	R-NUL-2534247	E-cadherin strand dimer degradation by Casp3	yes	reactome/R-NUL-2534247.md	E-cadherin strand dimer degradation by Casp3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with Casp3 as an executioner caspase that cleaves protein substrates during apoptotic execution.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	94	R-MMU-9763892	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	yes	reactome/R-MMU-9763892.md	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	Mus musculus	GO:0061630	ubiquitin protein ligase activity	TAS	enables	MF	false		ACCEPT	Core catalytic MF: RING-type E3 ligase that recruits E2~ubiquitin via its RING finger and transfers ubiquitin to activated receptor substrates; strongly supported (IDA:MGI plus IBA/IMP/ISS/TAS).
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	118	R-MMU-9680646	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	yes	reactome/R-MMU-9680646.md	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	119	R-MMU-9680706	Csf1r trans-autophosphorylates on multiple tyrosine residues	yes	reactome/R-MMU-9680706.md	Csf1r trans-autophosphorylates on multiple tyrosine residues	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	120	R-MMU-9682158	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	yes	reactome/R-MMU-9682158.md	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	121	R-MMU-9682182	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	yes	reactome/R-MMU-9682182.md	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	122	R-MMU-9763891	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	yes	reactome/R-MMU-9763891.md	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	123	R-MMU-9763892	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	yes	reactome/R-MMU-9763892.md	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cbl	genes/mouse/Cbl/Cbl-ai-review.yaml	Cbl	P22682	NCBITaxon:10090	Mus musculus	124	R-MMU-9817994	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	yes	reactome/R-MMU-9817994.md	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cbl is a baseline cytosolic adaptor/E3 (TAS:Reactome and ISO), recruited from the cytosol to activated membrane receptor complexes; a core site of action.
mouse	Cdc42	genes/mouse/Cdc42/Cdc42-ai-review.yaml	Cdc42	P60766	NCBITaxon:10090	Mus musculus	174	R-MMU-3928643	Activation of CDC42 by intersectin-1	yes	reactome/R-MMU-3928643.md	Activation of CDC42 by intersectin-1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core Cdc42 GTPase, cytoskeletal, polarity, or localization biology.
mouse	Cdc42	genes/mouse/Cdc42/Cdc42-ai-review.yaml	Cdc42	P60766	NCBITaxon:10090	Mus musculus	175	R-MMU-442572	Activation of WASP and N-WASP by CDC42	yes	reactome/R-MMU-442572.md	Activation of WASP and N-WASP by CDC42	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core Cdc42 GTPase, cytoskeletal, polarity, or localization biology.
mouse	Cdc42	genes/mouse/Cdc42/Cdc42-ai-review.yaml	Cdc42	P60766	NCBITaxon:10090	Mus musculus	176	R-MMU-448947	Interaction of Bnip-2 with Cdc42	yes	reactome/R-MMU-448947.md	Interaction of Bnip-2 with Cdc42	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core Cdc42 GTPase, cytoskeletal, polarity, or localization biology.
mouse	Cdc42	genes/mouse/Cdc42/Cdc42-ai-review.yaml	Cdc42	P60766	NCBITaxon:10090	Mus musculus	177	R-MMU-5665684	Fmnl1 binds Cdc42:GTP	yes	reactome/R-MMU-5665684.md	Fmnl1 binds Cdc42:GTP	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core Cdc42 GTPase, cytoskeletal, polarity, or localization biology.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	63	R-MMU-9634937	Cdk5r1 gene expression is stimulated by Npas4	yes	reactome/R-MMU-9634937.md	Cdk5r1 gene expression is stimulated by Npas4	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	74	R-MMU-8868356	Cdk5:p25 phosphorylates lamin A	yes	reactome/R-MMU-8868356.md	Cdk5:p25 phosphorylates lamin A	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported but downstream or context-specific Cdk5r1 biology.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	75	R-MMU-8868383	Cdk5:p25 phosphorylates lamin B1	yes	reactome/R-MMU-8868383.md	Cdk5:p25 phosphorylates lamin B1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Supported but downstream or context-specific Cdk5r1 biology.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	76	R-MMU-8863416	Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)	yes	reactome/R-MMU-8863416.md	Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	77	R-MMU-8868331	Cdk5:p25 phosphorylates Golga2	yes	reactome/R-MMU-8868331.md	Cdk5:p25 phosphorylates Golga2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	78	R-MMU-8868583	Cdk5:p25 phosphorylates Prdx1	yes	reactome/R-MMU-8868583.md	Cdk5:p25 phosphorylates Prdx1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	79	R-MMU-8868589	Cdk5:p25 phosphorylates Prdx2	yes	reactome/R-MMU-8868589.md	Cdk5:p25 phosphorylates Prdx2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	80	R-MMU-8868677	Cdk5:p25 phosphorylates Jun	yes	reactome/R-MMU-8868677.md	Cdk5:p25 phosphorylates Jun	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	81	R-NUL-8870566	Cdk5:p25 phosphorylates FOXO3	yes	reactome/R-NUL-8870566.md	Cdk5:p25 phosphorylates FOXO3	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Cdk5r1	genes/mouse/Cdk5r1/Cdk5r1-ai-review.yaml	Cdk5r1	P61809	NCBITaxon:10090	Mus musculus	82	R-MMU-8863416	Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)	yes	reactome/R-MMU-8863416.md	Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported core p35/p25-CDK5 regulatory function or neuronal localization/process.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	634	R-MMU-9773219	Cdh19 associates with catenins	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	635	R-MMU-9860515	Phosphorylation of Kdr and Flt4 in Pecam1:Cdh5:Kdr:Flt4:Ctnnb1 in response to shear stress	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	636	R-MMU-9860560	Phosphorylation of Pi3k in Pecam1:Cdh5:PiK3ca,b,d:Pik3r2:p-799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	637	R-MMU-9860569	Pik3ca,b,d:Pik3r2 (Pi3k) binds p-Y799,Y1052,Y1172-Kdr in Pecam1:Cdh5:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	638	R-MMU-9863577	Phospho-Pi3k in p-Pecam1:Cdh5:Pik3ca,b,d:p-Y458-Pik3r2:p-Y799,Y1052,Y1172-Kdr:p-Y1063,Y1230-Flt4:Ctnnb1 phosphorylates phosphatidylinositol-4,5-bisphosphate to yield phosphatidylinositol-3,4,5-trisphosphate	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	639	R-NUL-9761463	Ctnna1 binds to CDH11-bound Ctnnb1	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The majority of beta-catenin is at the plasma membrane within cadherin-catenin junctional complexes.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	642	R-MMU-9735211	Gata4 and Lef1:Ctnnb1 bind the Isl1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	643	R-MMU-9754284	Lef1 or Tcf7 (tcf1) and Ctnnb1 bind the Tbxt (T, Brachyury) gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	644	R-MMU-9793864	Tbx6 and Lef1:Ctnnb1 bind the Dll1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	645	R-MMU-9794042	Tbx6 and Lef1:Ctnnb1 bind the Msgn1 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	646	R-MMU-9823738	Tcf7l2:Ctnnb1, Foxa2, Mixl1, and Gata4 bind the Sox17 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	647	R-MMU-9824206	Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm	yes	reactome/R-MMU-9824206.md	Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	648	R-MMU-9824277	Msgn1 and Lef1:Ctnnb1 bind the Dll1 gene in presomitic mesoderm	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	649	R-MMU-9824278	Hes7 binds the Hes7 gene	yes	reactome/R-MMU-9824278.md	Hes7 binds the Hes7 gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Stabilized beta-catenin accumulates in the nucleoplasm to act as the Wnt transcriptional coactivator.
mouse	Ctnnb1	genes/mouse/Ctnnb1/Ctnnb1-ai-review.yaml	Ctnnb1	Q02248	NCBITaxon:10090	Mus musculus	759	R-MMU-209096	Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Beta-catenin has a cytosolic pool subject to destruction-complex regulation and Wnt-dependent stabilization.
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	87	R-MMU-573383	NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes	yes	reactome/R-MMU-573383.md	NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes	Mus musculus	GO:0009008	DNA-methyltransferase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	DNA-methyltransferase activity
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	88	R-MMU-5336369	Dnmt1 methylates cytosine in hemimethylated DNA	yes	reactome/R-MMU-5336369.md	Dnmt1 methylates cytosine in hemimethylated DNA	Mus musculus	GO:0051718	DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates	TAS	enables	MF	false		KEEP_AS_NON_CORE	DNA (cytosine-5-)-methyltransferase acti...
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	106	R-MMU-5336365	Uhrf1:Chromatin binds Dnmt1	yes	reactome/R-MMU-5336365.md	Uhrf1:Chromatin binds Dnmt1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	107	R-MMU-5336369	Dnmt1 methylates cytosine in hemimethylated DNA	yes	reactome/R-MMU-5336369.md	Dnmt1 methylates cytosine in hemimethylated DNA	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	108	R-MMU-573336	Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene	yes	reactome/R-MMU-573336.md	Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	109	R-MMU-573376	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene	yes	reactome/R-MMU-573376.md	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization
mouse	Dnmt1	genes/mouse/Dnmt1/Dnmt1-ai-review.yaml	Dnmt1	P13864	NCBITaxon:10090	Mus musculus	110	R-MMU-573383	NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes	yes	reactome/R-MMU-573383.md	NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nuclear localization
mouse	Egf	genes/mouse/Egf/Egf-ai-review.yaml	Egf	P01132	NCBITaxon:10090	Mus musculus	115	R-MMU-179883	Mouse pro-EGF is cleaved by ADAM sheddases	yes	reactome/R-MMU-179883.md	Mouse pro-EGF is cleaved by ADAM sheddases	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	The processed mature EGF peptide is released and acts in the extracellular region; secreted localization is core to a diffusible growth-factor ligand.
mouse	Egf	genes/mouse/Egf/Egf-ai-review.yaml	Egf	P01132	NCBITaxon:10090	Mus musculus	116	R-MMU-179883	Mouse pro-EGF is cleaved by ADAM sheddases	yes	reactome/R-MMU-179883.md	Mouse pro-EGF is cleaved by ADAM sheddases	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	The pro-EGF precursor is a single-pass type I plasma-membrane protein, and membrane-anchored pro-EGF can signal juxtacrine; an accurate, evidence-backed localization for the gene product.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	70	R-MMU-9006326	Epo binds Epor:Jak2:Lyn:Irs2	yes	reactome/R-MMU-9006326.md	Epo binds Epor:Jak2:Lyn:Irs2	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	71	R-MMU-9006327	Phospho-Jak2 phosphorylates Epor	yes	reactome/R-MMU-9006327.md	Phospho-Jak2 phosphorylates Epor	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	72	R-MMU-9006329	Jak2 transphosphorylates and is activated in response to Erythropoietin	yes	reactome/R-MMU-9006329.md	Jak2 transphosphorylates and is activated in response to Erythropoietin	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	73	R-MMU-9012652	p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2	yes	reactome/R-MMU-9012652.md	p-Stat5 dissociates from Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	74	R-MMU-9012653	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5	yes	reactome/R-MMU-9012653.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 phosphorylates Stat5	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	75	R-MMU-9012656	phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5	yes	reactome/R-MMU-9012656.md	phospho-Epor:phospho-Jak2:Lyn:Irs2 binds Stat5	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	76	R-MMU-9027266	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1	yes	reactome/R-MMU-9027266.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1 binds Shc1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	77	R-MMU-9027268	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k	yes	reactome/R-MMU-9027268.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Pi3k	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	78	R-MMU-9027429	Lyn phosphorylates Plcg1,2 in Epo receptor complex	yes	reactome/R-MMU-9027429.md	Lyn phosphorylates Plcg1,2 in Epo:phospho-Epor:phospho-Jak2:Lyn:Irs2:Plcg1,2	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	79	R-MMU-9027436	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2	yes	reactome/R-MMU-9027436.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Plcg1,2	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	80	R-MMU-9029146	Epo receptor complex binds Grb2:Sos1	yes	reactome/R-MMU-9029146.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	81	R-MMU-9029147	Jak2 phosphorylates Shc1 in Epo receptor complex	yes	reactome/R-MMU-9029147.md	Jak2 phosphorylates Shc1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef:Shc1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	82	R-MMU-9029152	Epo receptor complex mediates exchange of GDP for GTP bound to Ras	yes	reactome/R-MMU-9029152.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	83	R-MMU-9029162	Jak2 phosphorylates Vav1 in Epo receptor complex	yes	reactome/R-MMU-9029162.md	Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	84	R-MMU-9030346	Epo receptor complex binds Crkl:Rapgef1	yes	reactome/R-MMU-9030346.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2 binds Crkl:Rapgef1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	85	R-MMU-9030353	Lyn phosphorylates Crkl in Epo receptor complex	yes	reactome/R-MMU-9030353.md	Lyn phosphorylates Crkl in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:Crkl:Rapgef1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Epo	genes/mouse/Epo/Epo-ai-review.yaml	Epo	P07321	NCBITaxon:10090	Mus musculus	86	R-MMU-9032476	Epor-associated Plcg hydrolyzes phosphatidylinositol bisphosphate	yes	reactome/R-MMU-9032476.md	Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		ACCEPT	Epo is an extracellular secreted ligand.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	136	R-MMU-3928613	Fyn phosphorylates Nmdar2b	yes	reactome/R-MMU-3928613.md	Fyn phosphorylates Nmdar2b	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Fyn is a Src-family non-receptor tyrosine kinase (EC 2.7.10.2) that transfers phosphate from ATP to tyrosine residues of substrate proteins; this is its defining catalytic activity.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	137	R-MMU-9763891	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	yes	reactome/R-MMU-9763891.md	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Fyn is a Src-family non-receptor tyrosine kinase (EC 2.7.10.2) that transfers phosphate from ATP to tyrosine residues of substrate proteins; this is its defining catalytic activity.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	138	R-MMU-983702	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)	yes	reactome/R-MMU-983702.md	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Fyn is a Src-family non-receptor tyrosine kinase (EC 2.7.10.2) that transfers phosphate from ATP to tyrosine residues of substrate proteins; this is its defining catalytic activity.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	139	R-NUL-420398	Autophosphorylation of NCAM1 bound Fyn	yes	reactome/R-NUL-420398.md	Autophosphorylation of NCAM1 bound Fyn	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Fyn is a Src-family non-receptor tyrosine kinase (EC 2.7.10.2) that transfers phosphate from ATP to tyrosine residues of substrate proteins; this is its defining catalytic activity.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	167	R-MMU-1433273	Interaction of Src kinases with c-Kit	yes	reactome/R-MMU-1433273.md	Interaction of Src kinases with c-Kit	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	168	R-MMU-2395436	Phosphorylation of DAP12	yes	reactome/R-MMU-2395436.md	Phosphorylation of DAP12	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	169	R-MMU-3928613	Fyn phosphorylates Nmdar2b	yes	reactome/R-MMU-3928613.md	Fyn phosphorylates Nmdar2b	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	170	R-MMU-3928635	Ephb2 bind Nmdar	yes	reactome/R-MMU-3928635.md	Ephb2 bind Nmdar	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	171	R-MMU-9605258	Active Flt3 binds Fyn	yes	reactome/R-MMU-9605258.md	Active Flt3 binds Fyn	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	172	R-MMU-9680646	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	yes	reactome/R-MMU-9680646.md	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	173	R-MMU-9680706	Csf1r trans-autophosphorylates on multiple tyrosine residues	yes	reactome/R-MMU-9680706.md	Csf1r trans-autophosphorylates on multiple tyrosine residues	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	174	R-MMU-9682158	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	yes	reactome/R-MMU-9682158.md	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	175	R-MMU-9682182	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	yes	reactome/R-MMU-9682182.md	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	176	R-MMU-9682572	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	yes	reactome/R-MMU-9682572.md	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	177	R-MMU-9763891	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	yes	reactome/R-MMU-9763891.md	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	178	R-MMU-9763892	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	yes	reactome/R-MMU-9763892.md	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	179	R-MMU-9763903	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	yes	reactome/R-MMU-9763903.md	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	180	R-MMU-9764150	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	yes	reactome/R-MMU-9764150.md	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	181	R-MMU-9817994	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	yes	reactome/R-MMU-9817994.md	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	182	R-MMU-9818009	Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1	yes	reactome/R-MMU-9818009.md	Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	183	R-MMU-983702	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)	yes	reactome/R-MMU-983702.md	Phosphorylation of ITAMs of Ig-alpha (Cd79a) and Ig-beta (Cd79b)	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	184	R-NUL-420388	Dephosphorylation of NCAM1 bound pFyn	yes	reactome/R-NUL-420388.md	Dephosphorylation of NCAM1 bound pFyn	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	185	R-NUL-420398	Autophosphorylation of NCAM1 bound Fyn	yes	reactome/R-NUL-420398.md	Autophosphorylation of NCAM1 bound Fyn	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	186	R-NUL-421136	Recruitment and activation of Cdk5	yes	reactome/R-NUL-421136.md	Recruitment and activation of Cdk5	Gallus gallus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	187	R-NUL-421138	Activation of Fyn	yes	reactome/R-NUL-421138.md	Activation of Fyn	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	188	R-MMU-9032771	Dock3 binds Fyn associated with Ntrk2	yes	reactome/R-MMU-9032771.md	Dock3 binds Fyn associated with Ntrk2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Myristoylated and palmitoylated Fyn is targeted to the inner plasma membrane and lipid rafts where it engages receptor-proximal complexes.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	225	R-MMU-420382	Phosphorylation of FAK by Src kinases	yes	reactome/R-MMU-420382.md	Phosphorylation of FAK by Src kinases	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	226	R-MMU-420394	Recruitment of FAK to NCAM1:Fyn in lipid rafts	yes	reactome/R-MMU-420394.md	Recruitment of FAK to NCAM1:Fyn in lipid rafts	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Fyn	genes/mouse/Fyn/Fyn-ai-review.yaml	Fyn	P39688	NCBITaxon:10090	Mus musculus	227	R-NUL-420386	Fyn binds NCAM1	yes	reactome/R-NUL-420386.md	Fyn binds NCAM1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Fyn is a cytoplasmic kinase; the cytosol/cell membrane interface is a primary site of its action.
mouse	Gapdh	genes/mouse/Gapdh/Gapdh-ai-review.yaml	Gapdh	P16858	NCBITaxon:10090	Mus musculus	25	R-MMU-9631076	Hspa8:substrate binds late endosomal phospholipids	yes	reactome/R-MMU-9631076.md	Hspa8:substrate binds late endosomal phospholipids	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
mouse	Gapdh	genes/mouse/Gapdh/Gapdh-ai-review.yaml	Gapdh	P16858	NCBITaxon:10090	Mus musculus	26	R-MMU-9631080	Substrate translocates into late endosomal lumen	yes	reactome/R-MMU-9631080.md	Substrate translocates into late endosomal lumen	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome pathway annotation.
mouse	Gapdh	genes/mouse/Gapdh/Gapdh-ai-review.yaml	Gapdh	P16858	NCBITaxon:10090	Mus musculus	53	R-MMU-9631080	Substrate translocates into late endosomal lumen	yes	reactome/R-MMU-9631080.md	Substrate translocates into late endosomal lumen	Mus musculus	GO:0031906	late endosome lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for endosomal localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	63	R-MMU-1168790	ADAM17 cleavage of Ghr	yes	reactome/R-MMU-1168790.md	ADAM17 cleavage of Ghr	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	64	R-MMU-1168910	Stat5 association with Ghr	yes	reactome/R-MMU-1168910.md	Stat5 association with Ghr	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	65	R-MMU-1168923	Stat5 tyrosine phosphorylation	yes	reactome/R-MMU-1168923.md	Stat5 tyrosine phosphorylation	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	66	R-MMU-1168927	Growth hormone receptor binds Lyn	yes	reactome/R-MMU-1168927.md	Growth hormone receptor binds Lyn	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	67	R-MMU-1169194	Socs binding to JAK2	yes	reactome/R-MMU-1169194.md	Socs binding to JAK2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	68	R-MMU-1169229	Ptp1b dephosphorylates Jak2	yes	reactome/R-MMU-1169229.md	Ptp1b dephosphorylates Jak2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	69	R-MMU-1169240	Shp1 (Ptpn6) dephosphorylates Jak2	yes	reactome/R-MMU-1169240.md	Shp1 (Ptpn6) dephosphorylates Jak2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	70	R-MMU-1169250	Shp1 binds Jak2 in the receptor complex	yes	reactome/R-MMU-1169250.md	Shp1 binds Jak2 in the receptor complex	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	71	R-MMU-1169142	Jak2 binds Stat1/Stat3	yes	reactome/R-MMU-1169142.md	Jak2 binds Stat1/Stat3	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	72	R-MMU-1169206	Jak2 phosphorylates Stat1/Stat3	yes	reactome/R-MMU-1169206.md	Jak2 phosphorylates Stat1/Stat3	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway placement is consistent with accepted receptor localization.
mouse	Ghr	genes/mouse/Ghr/Ghr-ai-review.yaml	Ghr	P16882	NCBITaxon:10090	Mus musculus	73	R-MMU-1168790	ADAM17 cleavage of Ghr	yes	reactome/R-MMU-1168790.md	ADAM17 cleavage of Ghr	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome extracellular-region placement is plausible for GHBP/ectodomain biology but not the most informative core location.
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	127	R-MMU-2730846	Recruitment of Gab2 to PM and FCERI by binding to Grb2	yes	reactome/R-MMU-2730846.md	Recruitment of Gab2 to PM and FCERI by binding to Grb2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	128	R-MMU-2730869	Phosphorylation of Gab2 by Syk/Fyn	yes	reactome/R-MMU-2730869.md	Phosphorylation of Gab2 by Syk/Fyn	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	129	R-MMU-8983356	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2	yes	reactome/R-MMU-8983356.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	130	R-MMU-9007126	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2	yes	reactome/R-MMU-9007126.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	131	R-MMU-9007137	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2	yes	reactome/R-MMU-9007137.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	132	R-MMU-914067	Shp2 can recruit Grb2	yes	reactome/R-MMU-914067.md	Shp2 can recruit Grb2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	133	R-MMU-9604768	Active Flt3 dimer binds Grb2	yes	reactome/R-MMU-9604768.md	Active Flt3 dimer binds Grb2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	134	R-MMU-9606621	Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated	yes	reactome/R-MMU-9606621.md	Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	135	R-MMU-9606623	Active Flt3:Grb2 binds Gab2	yes	reactome/R-MMU-9606623.md	Active Flt3:Grb2 binds Gab2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	136	R-MMU-9606789	Active Flt3:Grb2:p-Y-Gab2 binds Ptpn11	yes	reactome/R-MMU-9606789.md	Active Flt3:Grb2:p-Y-Gab2 binds Ptpn11	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	137	R-MMU-9607226	Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1	yes	reactome/R-MMU-9607226.md	Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	138	R-MMU-9645128	Activators bind Stat5	yes	reactome/R-MMU-9645128.md	Activators bind Stat5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	139	R-MMU-9645133	p-Stat5 dissociates from activator:Stat5 complex	yes	reactome/R-MMU-9645133.md	p-Stat5 dissociates from activator:Stat5 complex	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	140	R-MMU-9645136	Activator phosphorylates Stat5	yes	reactome/R-MMU-9645136.md	Activator phosphorylates Stat5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	141	R-MMU-9674973	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	yes	reactome/R-MMU-9674973.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	142	R-MMU-9680646	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	yes	reactome/R-MMU-9680646.md	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	143	R-MMU-9682158	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	yes	reactome/R-MMU-9682158.md	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	144	R-MMU-9682182	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	yes	reactome/R-MMU-9682182.md	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	145	R-MMU-9029146	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1	yes	reactome/R-MMU-9029146.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1 binds Grb2-1:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	146	R-MMU-9029152	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	yes	reactome/R-MMU-9029152.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	147	R-MMU-9029162	Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1	yes	reactome/R-MMU-9029162.md	Jak2 phosphorylates Vav1 in Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Crkl:Rapgef1:p-Y-Shc1:Grb2-1:Vav1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	148	R-MMU-9682572	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	yes	reactome/R-MMU-9682572.md	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	149	R-MMU-9763903	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	yes	reactome/R-MMU-9763903.md	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	150	R-MMU-9764150	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	yes	reactome/R-MMU-9764150.md	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Grb2	genes/mouse/Grb2/Grb2-ai-review.yaml	Grb2	Q60631	NCBITaxon:10090	Mus musculus	151	R-NUL-9036961	Ntrk3 binds Grb2 through Shc1	yes	reactome/R-NUL-9036961.md	Ntrk3 binds Grb2 through Shc1	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Grb2 is predominantly a cytosolic adaptor at steady state, recruited to membranes upon receptor activation; the cytosol is a primary site where it resides and acts. Core localization (n=27).
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	151	R-MMU-573376	Reactome pathway annotation	yes	reactome/R-MMU-573376.md	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene	Mus musculus	GO:0004407	histone deacetylase activity	TAS	enables	MF	false		ACCEPT	HDAC1 is a zinc-dependent histone deacetylase (EC 3.5.1.98) that catalyzes removal of acetyl groups from N-acetyl-lysine residues on histones H2A, H2B, H3, and H4. This is the core enzymatic function of HDAC1, well established by direct biochemical assays (PMID:10615135, PMID:21960634, PMID:30279482).
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	189	R-MMU-573336	Reactome pathway annotation	yes	reactome/R-MMU-573336.md	Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	190	R-MMU-573376	Reactome pathway annotation	yes	reactome/R-MMU-573376.md	NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	191	R-MMU-573383	Reactome pathway annotation	yes	reactome/R-MMU-573383.md	NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	192	R-MMU-8978954	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	193	R-MMU-8978970	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	194	R-MMU-8978980	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	195	R-MMU-8978989	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	196	R-MMU-9006133	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	197	R-MMU-9017958	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	198	R-MMU-9625109	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	199	R-MMU-9727502	Reactome pathway annotation	yes	reactome/R-MMU-9727502.md	Piwil4:piRNA binds nascent RNA transcript and recruits Spocd1, Gm52993 (C19orf84), Dnmt3a, Dnmt3c, Dnmt3l, the NURD complex, and the BAF complex	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	200	R-MMU-9844527	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	201	R-MMU-9845305	Reactome pathway annotation	yes	reactome/R-MMU-9845305.md	Dnmt3a:Dnmt3l in nascent RNA transcript:MeR-Piwil4:2'-O-methyl-piRNA:Spocd11:Dnmt3a:Dnmt3l methylates cytosine in DNA	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	202	R-NUL-573373	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hdac1	genes/mouse/Hdac1/Hdac1-ai-review.yaml	Hdac1	O09106	NCBITaxon:10090	Mus musculus	203	R-NUL-573385	Reactome pathway annotation	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	HDAC1 is localized to the nucleoplasm where it functions as part of chromatin-modifying complexes.
mouse	Hras	genes/mouse/Hras/Hras-ai-review.yaml	Hras	Q61411	NCBITaxon:10090	Mus musculus	107	R-MMU-9029152	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	yes	reactome/R-MMU-9029152.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core H-Ras switch activity, effector signaling, or localization.
mouse	Hras	genes/mouse/Hras/Hras-ai-review.yaml	Hras	Q61411	NCBITaxon:10090	Mus musculus	108	R-NUL-1250468	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	yes	reactome/R-NUL-1250468.md	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core H-Ras switch activity, effector signaling, or localization.
mouse	Hras	genes/mouse/Hras/Hras-ai-review.yaml	Hras	Q61411	NCBITaxon:10090	Mus musculus	109	R-NUL-1250472	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	yes	reactome/R-NUL-1250472.md	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane is consistent with core H-Ras switch activity, effector signaling, or localization.
mouse	Hsp90aa1	genes/mouse/Hsp90aa1/Hsp90aa1-ai-review.yaml	Hsp90aa1	P07901	NCBITaxon:10090	Mus musculus	187	R-MMU-9646345	Ubiquitin binds Vcp:Hdac6:Hsp90:Hsf1	yes	reactome/R-MMU-9646345.md	Ubiquitin binds Vcp:Hdac6:Hsp90:Hsf1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.
mouse	Hsp90aa1	genes/mouse/Hsp90aa1/Hsp90aa1-ai-review.yaml	Hsp90aa1	P07901	NCBITaxon:10090	Mus musculus	188	R-MMU-9646359	PolyUb-Misfolded Proteins:Hdac6 dissociate from complex	yes	reactome/R-MMU-9646359.md	PolyUb-Misfolded Proteins:Hdac6 dissociate from complex	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with the core ATP-dependent Hsp90 chaperone cycle and principal cytosolic/nuclear localization.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	203	R-MMU-9631080	Substrate translocates into late endosomal lumen	yes	reactome/R-MMU-9631080.md	Substrate translocates into late endosomal lumen	Mus musculus	GO:0031906	late endosome lumen	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for substrate translocation into late endosomal lumen. Consistent with Hsc70 role in endosomal microautophagy (PMID:21238931).
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	205	R-MMU-9613507	Plins:Hspa8 binds Prkaa2	yes	reactome/R-MMU-9613507.md	Plins:Hspa8 binds Prkaa2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for Plins/Hspa8 binding Prkaa2. Cytosolic localization is well established.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	206	R-MMU-9613545	Prkaa2 phosphorylates Plins	yes	reactome/R-MMU-9613545.md	Prkaa2 phosphorylates Plins	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for Prkaa2 phosphorylation of Plins. Redundant cytosol annotation.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	207	R-MMU-9613562	Prkaa2 dissociate from p-Plins:Hspa8	yes	reactome/R-MMU-9613562.md	Prkaa2 dissociate from p-Plins:Hspa8	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for Prkaa2 dissociation from p-Plins/Hspa8. Redundant cytosol annotation.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	208	R-MMU-9613670	p-Plins translocate from lipid droplet surface to cytosol	yes	reactome/R-MMU-9613670.md	p-Plins translocate from lipid droplet surface to cytosol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for p-Plins translocation from lipid droplet to cytosol. Redundant cytosol annotation.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	209	R-MMU-9631076	Hspa8:substrate binds late endosomal phospholipids	yes	reactome/R-MMU-9631076.md	Hspa8:substrate binds late endosomal phospholipids	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for Hspa8/substrate binding to late endosomal phospholipids. Redundant cytosol annotation.
mouse	Hspa8	genes/mouse/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63017	NCBITaxon:10090	Mus musculus	210	R-MMU-9631080	Substrate translocates into late endosomal lumen	yes	reactome/R-MMU-9631080.md	Substrate translocates into late endosomal lumen	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS from Reactome pathway for substrate translocation into late endosomal lumen. Redundant cytosol annotation.
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	54	R-MMU-9674908	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	yes	reactome/R-MMU-9674908.md	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core JAK1 non-receptor tyrosine kinase activity
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	55	R-MMU-9674921	p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2	yes	reactome/R-MMU-9674921.md	p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core JAK1 non-receptor tyrosine kinase activity
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	61	R-MMU-8983294	Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1	yes	reactome/R-MMU-8983294.md	Il15ra:Il15:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 phosphorylates Shc1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	62	R-MMU-8983313	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 binds Shc1	yes	reactome/R-MMU-8983313.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3 binds Shc1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	63	R-MMU-8983356	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2	yes	reactome/R-MMU-8983356.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1 binds Grb2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	64	R-MMU-9007126	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2	yes	reactome/R-MMU-9007126.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2 binds Gab2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	65	R-MMU-9007137	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2	yes	reactome/R-MMU-9007137.md	Il15:Il15ra:p-Y-Il2rb:p-Y-Jak1:p-Y-Il2rg:p-Y-Jak3:p-Y-Shc1:Grb2:Gab2 phosphorylates Gab2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	66	R-MMU-9009867	Il2rb and Il2rg are phosphorylated	yes	reactome/R-MMU-9009867.md	Il2rb and Il2rg are phosphorylated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	67	R-MMU-9674900	Csf3:Csf3r induces phosphorylation of Jak1	yes	reactome/R-MMU-9674900.md	Csf3:Csf3r induces phosphorylation of Jak1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	68	R-MMU-9674908	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	yes	reactome/R-MMU-9674908.md	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	69	R-MMU-9674921	p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2	yes	reactome/R-MMU-9674921.md	p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	70	R-MMU-9674931	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	yes	reactome/R-MMU-9674931.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	71	R-MMU-9674959	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	yes	reactome/R-MMU-9674959.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	72	R-MMU-9674973	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	yes	reactome/R-MMU-9674973.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	73	R-MMU-9676072	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2	yes	reactome/R-MMU-9676072.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	74	R-MMU-9705471	Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2	yes	reactome/R-MMU-9705471.md	Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	75	R-MMU-9707972	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7	yes	reactome/R-MMU-9707972.md	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	76	R-MMU-9707979	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed	yes	reactome/R-MMU-9707979.md	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	80	R-MMU-1295758	Il7:p-Y449-Il7r:Jak1:Il2rg:Jak3 binds Pi3k regulatory subunits	yes	reactome/R-MMU-1295758.md	Il7:p-Y449-Il7r:Jak1:Il2rg:Jak3 binds Pi3k regulatory subunits	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	81	R-MMU-1295764	IL7r is phosphorylated on Y449	yes	reactome/R-MMU-1295764.md	IL7r is phosphorylated on Y449	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	82	R-MMU-1295768	Jak1 binds Il7r	yes	reactome/R-MMU-1295768.md	Jak1 binds Il7r	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	83	R-MMU-8950409	Il27ra binds Jak1	yes	reactome/R-MMU-8950409.md	Il27ra binds Jak1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Jak1	genes/mouse/Jak1/Jak1-ai-review.yaml	Jak1	P52332	NCBITaxon:10090	Mus musculus	84	R-NUL-1067645	Jaks associate with IL6RB (gp130)	yes	reactome/R-NUL-1067645.md	Jaks associate with IL6RB (gp130)	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Kras	genes/mouse/Kras/Kras-ai-review.yaml	Kras	P32883	NCBITaxon:10090	Mus musculus	51	R-MMU-9029152	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	yes	reactome/R-MMU-9029152.md	Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Crkl:p-Y-Shc1:Grb2-1:Sos1,p-Y-Vav1 mediates exchange of GDP for GTP bound to Ras	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output.
mouse	Kras	genes/mouse/Kras/Kras-ai-review.yaml	Kras	P32883	NCBITaxon:10090	Mus musculus	52	R-MMU-9682572	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	yes	reactome/R-MMU-9682572.md	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output.
mouse	Kras	genes/mouse/Kras/Kras-ai-review.yaml	Kras	P32883	NCBITaxon:10090	Mus musculus	53	R-NUL-1250468	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	yes	reactome/R-NUL-1250468.md	Ras guanyl-nucleotide exchange mediated by Sos1 in complex with GRB2 and P-Erbb2mut	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output.
mouse	Kras	genes/mouse/Kras/Kras-ai-review.yaml	Kras	P32883	NCBITaxon:10090	Mus musculus	54	R-NUL-1250472	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	yes	reactome/R-NUL-1250472.md	Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Supported as part of the core KRAS small-GTPase switch, membrane localization, or proximal Ras/MAPK signaling output.
mouse	Mapk1	genes/mouse/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63085	NCBITaxon:10090	Mus musculus	68	R-MMU-198706	ERK1/2 activates ELK1	yes	reactome/R-MMU-198706.md	ERK1/2 activates ELK1	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Mapk1	genes/mouse/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63085	NCBITaxon:10090	Mus musculus	69	R-MMU-9769840	Mapk1,(Mapk3) phosphorylate Npas4	yes	reactome/R-MMU-9769840.md	Mapk1,(Mapk3) phosphorylate Npas4	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Mapk1	genes/mouse/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63085	NCBITaxon:10090	Mus musculus	140	R-MMU-198706	ERK1/2 activates ELK1	yes	reactome/R-MMU-198706.md	ERK1/2 activates ELK1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Mapk1	genes/mouse/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63085	NCBITaxon:10090	Mus musculus	141	R-MMU-9769840	Mapk1,(Mapk3) phosphorylate Npas4	yes	reactome/R-MMU-9769840.md	Mapk1,(Mapk3) phosphorylate Npas4	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Mapk3	genes/mouse/Mapk3/Mapk3-ai-review.yaml	Mapk3	Q63844	NCBITaxon:10090	Mus musculus	55	R-MMU-198706	ERK1/2 activates ELK1	yes	reactome/R-MMU-198706.md	ERK1/2 activates ELK1	Mus musculus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	protein serine/threonine kinase activity is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Mapk3	genes/mouse/Mapk3/Mapk3-ai-review.yaml	Mapk3	Q63844	NCBITaxon:10090	Mus musculus	130	R-MMU-198706	ERK1/2 activates ELK1	yes	reactome/R-MMU-198706.md	ERK1/2 activates ELK1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is consistent with core ERK MAP kinase activity, phosphorylation, cascade function, or localization.
mouse	Myc	genes/mouse/Myc/Myc-ai-review.yaml	Myc	P01108	NCBITaxon:10090	Mus musculus	112	R-MMU-9634437	Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa	yes	reactome/R-MMU-9634437.md	Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is consistent with Myc as a nuclear Myc-Max DNA-binding transcription factor that regulates RNA polymerase II target genes.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	176	R-MMU-9793875	Dll3 binds Notch1	yes	reactome/R-MMU-9793875.md	Dll3 binds Notch1	Mus musculus	GO:0010008	endosome membrane	TAS	located_in	CC	false		ACCEPT	Endosome membrane
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	309	R-MMU-4396387	mNOTCH1 coactivator complex bind promoters of Hey genes	yes	reactome/R-MMU-4396387.md	mNOTCH1 coactivator complex bind promoters of Hey genes	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	310	R-MMU-9667655	Nbea binds nicd1	yes	reactome/R-MMU-9667655.md	Nbea binds nicd1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	311	R-MMU-9824206	Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm	yes	reactome/R-MMU-9824206.md	Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	312	R-MMU-9824230	Hes7 binds the Lfng gene	yes	reactome/R-MMU-9824230.md	Hes7 binds the Lfng gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	313	R-MMU-9824231	Rbpj:Nicd and Msgn1 bind the Lfng gene	yes	reactome/R-MMU-9824231.md	Rbpj:Nicd and Msgn1 bind the Lfng gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	314	R-MMU-9824278	Hes7 binds the Hes7 gene	yes	reactome/R-MMU-9824278.md	Hes7 binds the Hes7 gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	315	R-NUL-2064853	FBXW7 binds phosphorylated NICD1	yes	reactome/R-NUL-2064853.md	FBXW7 binds phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	316	R-NUL-2064883	FBXW7 mediates ubiquitination of phosphorylated NICD1	yes	reactome/R-NUL-2064883.md	FBXW7 mediates ubiquitination of phosphorylated NICD1	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	317	R-NUL-2065560	mNICD1 binds HIF1A	yes	reactome/R-NUL-2065560.md	mNICD1 binds HIF1A	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	318	R-NUL-4396363	mNICD1 Chimeric Enhancer Complex binds Hes1 promoter	yes	reactome/R-NUL-4396363.md	mNICD1 Chimeric Enhancer Complex binds Hes1 promoter	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	319	R-MMU-2067638	Gamma secretase cleaves Dner:Notch1 complex	yes	reactome/R-MMU-2067638.md	Gamma secretase cleaves Dner:Notch1 complex	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	320	R-MMU-209285	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm	yes	reactome/R-MMU-209285.md	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	321	R-NUL-2065902	Gamma secretase complex cleaves Cntn1-actived Notch1	yes	reactome/R-NUL-2065902.md	Gamma secretase complex cleaves Cntn1-actived Notch1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	329	R-MMU-2053938	Dll4 binds Notch1	yes	reactome/R-MMU-2053938.md	Dll4 binds Notch1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	330	R-MMU-2053963	Notch1 binds Jag1	yes	reactome/R-MMU-2053963.md	Notch1 binds Jag1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	331	R-MMU-2066712	Dner binds Notch1	yes	reactome/R-MMU-2066712.md	Dner binds Notch1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	332	R-MMU-2067638	Gamma secretase cleaves Dner:Notch1 complex	yes	reactome/R-MMU-2067638.md	Gamma secretase cleaves Dner:Notch1 complex	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	333	R-MMU-2071906	Notch1 binds Dlk1	yes	reactome/R-MMU-2071906.md	Notch1 binds Dlk1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	334	R-MMU-2077477	Numb recruits Itch to Notch1	yes	reactome/R-MMU-2077477.md	Numb recruits Itch to Notch1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	335	R-MMU-2077479	Itch ubiquitinates Notch	yes	reactome/R-MMU-2077479.md	Itch ubiquitinates Notch	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	336	R-NUL-2065902	Gamma secretase complex cleaves Cntn1-actived Notch1	yes	reactome/R-NUL-2065902.md	Gamma secretase complex cleaves Cntn1-actived Notch1	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	337	R-NUL-209162	Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD	yes	reactome/R-NUL-209162.md	Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD	Mus musculus	GO:0005576	extracellular region	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Notch1 annotation to extracellular region.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	338	R-MMU-2023158	Glycosylation of Pre-Notch by Fringe	yes	reactome/R-MMU-2023158.md	Glycosylation of Pre-Notch by Fringe	Mus musculus	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Notch1 undergoes S1 cleavage by furin in the trans-Golgi network during maturation, converting the precursor into the functional heterodimer.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	339	R-MMU-2032750	Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum	yes	reactome/R-MMU-2032750.md	Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum	Mus musculus	GO:0000139	Golgi membrane	TAS	located_in	CC	false		ACCEPT	Notch1 undergoes S1 cleavage by furin in the trans-Golgi network during maturation, converting the precursor into the functional heterodimer.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	340	R-MMU-2023179	Glucosylation of Pre-Notch by Poglut1	yes	reactome/R-MMU-2023179.md	Glucosylation of Pre-Notch by Poglut1	Mus musculus	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is synthesized and begins its maturation in the ER membrane before trafficking to the Golgi.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	341	R-MMU-2032750	Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum	yes	reactome/R-MMU-2032750.md	Sel1l negatively regulates Pre-Notch exit from endoplasmic reticulum	Mus musculus	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is synthesized and begins its maturation in the ER membrane before trafficking to the Golgi.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	342	R-MMU-9824249	Expression of Notch1 in presomitic mesoderm	yes	reactome/R-MMU-9824249.md	Expression of Notch1 in presomitic mesoderm	Mus musculus	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is synthesized and begins its maturation in the ER membrane before trafficking to the Golgi.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	343	R-NUL-1986584	Fucosylation of Pre-Notch by POFUT1	yes	reactome/R-NUL-1986584.md	Fucosylation of Pre-Notch by POFUT1	Cricetulus griseus	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is synthesized and begins its maturation in the ER membrane before trafficking to the Golgi.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	344	R-MMU-209285	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm	yes	reactome/R-MMU-209285.md	The transmembrane complex Murine gamma-secretase cleaves Murine NEXT at the S3 site leaving NTM and releasing NICD into the cytoplasm	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	345	R-NUL-2063915	ADAM17 cleaves Notch1 at S2	yes	reactome/R-NUL-2063915.md	ADAM17 cleaves Notch1 at S2	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	346	R-NUL-209162	Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD	yes	reactome/R-NUL-209162.md	Murine ADAM10 cleaves Notch at the S2 site producing transmembrane spanning NEXT and ligand-bound NECD	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	347	R-MMU-2053938	Dll4 binds Notch1	yes	reactome/R-MMU-2053938.md	Dll4 binds Notch1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	395	R-MMU-2053963	Notch1 binds Jag1	yes	reactome/R-MMU-2053963.md	Notch1 binds Jag1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	396	R-MMU-2066712	Dner binds Notch1	yes	reactome/R-MMU-2066712.md	Dner binds Notch1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	397	R-MMU-2067638	Gamma secretase cleaves Dner:Notch1 complex	yes	reactome/R-MMU-2067638.md	Gamma secretase cleaves Dner:Notch1 complex	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	398	R-MMU-2071906	Notch1 binds Dlk1	yes	reactome/R-MMU-2071906.md	Notch1 binds Dlk1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	399	R-MMU-2077477	Numb recruits Itch to Notch1	yes	reactome/R-MMU-2077477.md	Numb recruits Itch to Notch1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	400	R-MMU-2077479	Itch ubiquitinates Notch	yes	reactome/R-MMU-2077479.md	Itch ubiquitinates Notch	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Notch1	genes/mouse/Notch1/Notch1-ai-review.yaml	Notch1	Q01705	NCBITaxon:10090	Mus musculus	401	R-NUL-2065902	Gamma secretase complex cleaves Cntn1-actived Notch1	yes	reactome/R-NUL-2065902.md	Gamma secretase complex cleaves Cntn1-actived Notch1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Notch1 is a type I transmembrane receptor that resides at the plasma membrane where it receives ligand signals from adjacent cells.
mouse	Pld4	genes/mouse/Pld4/Pld4-ai-review.yaml	Pld4	Q8BG07	NCBITaxon:10090	Mus musculus	22	R-MMU-1483172	PC is transphosphatidylated to PG by Pld1-4/6	yes	reactome/R-MMU-1483172.md	PC is transphosphatidylated to PG by Pld1-4/6	Mus musculus	GO:0004630	D-type glycerophospholipase activity	TAS	enables	MF	false		REMOVE	This is a positive Reactome annotation to phospholipase D activity, but experimental evidence shows PLD4 lacks authentic PLD activity.
mouse	Pld4	genes/mouse/Pld4/Pld4-ai-review.yaml	Pld4	Q8BG07	NCBITaxon:10090	Mus musculus	34	R-MMU-1483172	PC is transphosphatidylated to PG by Pld1-4/6	yes	reactome/R-MMU-1483172.md	PC is transphosphatidylated to PG by Pld1-4/6	Mus musculus	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	ER membrane localization in agreement with experimental evidence.
mouse	Sox2	genes/mouse/Sox2/Sox2-ai-review.yaml	Sox2	P48432	NCBITaxon:10090	Mus musculus	68	R-MMU-9615549	Mecp2 and Sox2 bind Mir137 gene	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	IDA evidence based on immunofluorescence localization.
mouse	Sox2	genes/mouse/Sox2/Sox2-ai-review.yaml	Sox2	P48432	NCBITaxon:10090	Mus musculus	69	R-MMU-9832812	Expression of Sox2 in anterior neural plate	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	IDA evidence based on immunofluorescence localization.
mouse	Sox2	genes/mouse/Sox2/Sox2-ai-review.yaml	Sox2	P48432	NCBITaxon:10090	Mus musculus	70	R-MMU-9833004	Expression of Sox2 in posterior neural plate	no				GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	IDA evidence based on immunofluorescence localization.
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	220	R-MMU-3928622	SFKs phosphorylate Git1	yes	reactome/R-MMU-3928622.md	SFKs phosphorylate Git1	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	221	R-MMU-418870	Phosphorylation of Unc5C	yes	reactome/R-MMU-418870.md	Phosphorylation of Unc5C	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	222	R-MMU-420382	Phosphorylation of FAK by Src kinases	yes	reactome/R-MMU-420382.md	Phosphorylation of FAK by Src kinases	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	223	R-MMU-9011252	Src phosphorylates Robo3.1 in response to Ntn1	yes	reactome/R-MMU-9011252.md	Src phosphorylates Robo3.1 in response to Ntn1	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	224	R-MMU-9763891	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	yes	reactome/R-MMU-9763891.md	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	Mus musculus	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	225	R-NUL-9726861	Src phosphorylates RHOU	yes	reactome/R-NUL-9726861.md	Src phosphorylates RHOU	Homo sapiens	GO:0004713	protein tyrosine kinase activity	TAS	enables	MF	false		ACCEPT	Core SRC non-receptor tyrosine kinase activity
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	252	R-MMU-9011252	Src phosphorylates Robo3.1 in response to Ntn1	yes	reactome/R-MMU-9011252.md	Src phosphorylates Robo3.1 in response to Ntn1	Mus musculus	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	253	R-NUL-9726861	Src phosphorylates RHOU	yes	reactome/R-NUL-9726861.md	Src phosphorylates RHOU	Homo sapiens	GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	plasma membrane localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	254	R-NUL-9700655	Active ALK phosphorylates Src	yes	reactome/R-NUL-9700655.md	Active ALK phosphorylates Src	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	257	R-MMU-8937703	Runx1 binds Src	yes	reactome/R-MMU-8937703.md	Runx1 binds Src	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm pathway context
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	258	R-MMU-8937738	Src phosphorylates Runx1	yes	reactome/R-MMU-8937738.md	Src phosphorylates Runx1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	nucleoplasm pathway context
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	303	R-MMU-1433273	Interaction of Src kinases with c-Kit	yes	reactome/R-MMU-1433273.md	Interaction of Src kinases with c-Kit	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	304	R-MMU-3928622	SFKs phosphorylate Git1	yes	reactome/R-MMU-3928622.md	SFKs phosphorylate Git1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	305	R-MMU-418870	Phosphorylation of Unc5C	yes	reactome/R-MMU-418870.md	Phosphorylation of Unc5C	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	306	R-MMU-420382	Phosphorylation of FAK by Src kinases	yes	reactome/R-MMU-420382.md	Phosphorylation of FAK by Src kinases	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	307	R-MMU-5218834	Fak/Src phosphorylate p130Cas	yes	reactome/R-MMU-5218834.md	Fak/Src phosphorylate p130Cas	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	308	R-MMU-8964229	G alpha (i):GTP binds Src	yes	reactome/R-MMU-8964229.md	G alpha (i):GTP binds Src	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	309	R-MMU-9680646	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	yes	reactome/R-MMU-9680646.md	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	310	R-MMU-9680706	Csf1r trans-autophosphorylates on multiple tyrosine residues	yes	reactome/R-MMU-9680706.md	Csf1r trans-autophosphorylates on multiple tyrosine residues	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	311	R-MMU-9682158	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	yes	reactome/R-MMU-9682158.md	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	312	R-MMU-9682182	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	yes	reactome/R-MMU-9682182.md	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	313	R-MMU-9682572	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	yes	reactome/R-MMU-9682572.md	Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	314	R-MMU-9763891	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	yes	reactome/R-MMU-9763891.md	Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	315	R-MMU-9763892	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	yes	reactome/R-MMU-9763892.md	p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	316	R-MMU-9763903	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	yes	reactome/R-MMU-9763903.md	Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	317	R-MMU-9764150	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	yes	reactome/R-MMU-9764150.md	Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	318	R-MMU-9817994	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	yes	reactome/R-MMU-9817994.md	Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	319	R-MMU-9818009	Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1	yes	reactome/R-MMU-9818009.md	Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Src	genes/mouse/Src/Src-ai-review.yaml	Src	P05480	NCBITaxon:10090	Mus musculus	320	R-NUL-9700661	Active ALK binds Src	yes	reactome/R-NUL-9700661.md	Active ALK binds Src	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	102	R-MMU-9676907	p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus	yes	reactome/R-MMU-9676907.md	p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	103	R-MMU-9705459	p-Y-Stat1,3,5 dimer binds Socs3 gene	yes	reactome/R-MMU-9705459.md	p-Y-Stat1,3,5 dimer binds Socs3 gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	104	R-MMU-9705472	p-Y-Stat1,3,5 dimer binds Socs1 gene	yes	reactome/R-MMU-9705472.md	p-Y-Stat1,3,5 dimer binds Socs1 gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	105	R-MMU-9943422	Stat4 binds the Tbx21 (T-bet) gene	yes	reactome/R-MMU-9943422.md	Stat4 binds the Tbx21 (T-bet) gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	106	R-MMU-9943424	Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene	yes	reactome/R-MMU-9943424.md	Stat1 and Nfatc1 bind the Tbx21 (T-bet) gene	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	111	R-MMU-1169206	Jak2 phosphorylates Stat1/Stat3	yes	reactome/R-MMU-1169206.md	Jak2 phosphorylates Stat1/Stat3	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	112	R-MMU-9674908	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	yes	reactome/R-MMU-9674908.md	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	113	R-MMU-9674931	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	yes	reactome/R-MMU-9674931.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	114	R-MMU-9676907	p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus	yes	reactome/R-MMU-9676907.md	p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	115	R-MMU-9676912	p-Y-Stat1,3,5 dimerize	yes	reactome/R-MMU-9676912.md	p-Y-Stat1,3,5 dimerize	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	116	R-MMU-9680646	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	yes	reactome/R-MMU-9680646.md	Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	117	R-MMU-9682158	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	yes	reactome/R-MMU-9682158.md	Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	118	R-MMU-9682182	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	yes	reactome/R-MMU-9682182.md	Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	129	R-MMU-1169142	Jak2 binds Stat1/Stat3	yes	reactome/R-MMU-1169142.md	Jak2 binds Stat1/Stat3	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	130	R-MMU-9008004	Runx2 binds Stat1	yes	reactome/R-MMU-9008004.md	Runx2 binds Stat1	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Stat1	genes/mouse/Stat1/Stat1-ai-review.yaml	Stat1	P42225	NCBITaxon:10090	Mus musculus	131	R-MMU-9674959	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	yes	reactome/R-MMU-9674959.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol localization
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	204	R-MMU-9674908	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	yes	reactome/R-MMU-9674908.md	p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	205	R-MMU-9674931	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	yes	reactome/R-MMU-9674931.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	206	R-MMU-9674959	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	yes	reactome/R-MMU-9674959.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	207	R-MMU-9674973	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	yes	reactome/R-MMU-9674973.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds and phosphorylates Shc1, Grb2, Gab2, and Ptpn11	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	208	R-MMU-9676072	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2	yes	reactome/R-MMU-9676072.md	Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	209	R-MMU-9705471	Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2	yes	reactome/R-MMU-9705471.md	Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	210	R-MMU-9707972	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7	yes	reactome/R-MMU-9707972.md	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	211	R-MMU-9707979	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed	yes	reactome/R-MMU-9707979.md	Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 is endocytosed	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	212	R-MMU-5621346	Plcg1 binds p-Y348,352,525,526-Syk	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	213	R-MMU-9607032	Lyn, p-Syk phosphorylate Btk	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	218	R-MMU-442289	Syk binds Vav2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Syk	genes/mouse/Syk/Syk-ai-review.yaml	Syk	P48025	NCBITaxon:10090	Mus musculus	219	R-MMU-5607754	1,3-beta-D-glucan:p-15Y-Clec7a:Syk phosphorylates Plcg2	no				GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	cytosol is consistent with core Syk kinase, receptor-proximal signaling, or localization.
mouse	Top2a	genes/mouse/Top2a/Top2a-ai-review.yaml	Top2a	Q01320	NCBITaxon:10090	Mus musculus	75	R-MMU-5228515	RanBP2 Sumoylates Top2a with Sumo1	yes	reactome/R-MMU-5228515.md	RanBP2 Sumoylates Top2a with Sumo1	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Nucleoplasmic localization consistent with chromatin-associated activity; a valid sub-nuclear localization, secondary to the core MF.
mouse	Trp53	genes/mouse/Trp53/Trp53-ai-review.yaml	Trp53	P02340	NCBITaxon:10090	Mus musculus	158	R-MMU-9816449	Dppa2 and Dppa4 bind the Dux gene cluster	yes	reactome/R-MMU-9816449.md	Dppa2 and Dppa4 bind the Dux gene cluster	Mus musculus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	nucleoplasm is consistent with the curated mouse p53 biology as a stress-activated DNA-binding transcription factor, transcriptional regulator, or well-supported subcellular context.
mouse	Txn1	genes/mouse/Txn1/Txn1-ai-review.yaml	Txn1	P10639	NCBITaxon:10090	Mus musculus	16	R-MMU-1250256	Txnip is released from oxidized thioredoxin	yes	reactome/R-MMU-1250256.md	Txnip is released from oxidized thioredoxin	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Reactome annotation for TXNIP release from oxidized thioredoxin in cytosol.
mouse	Uox	genes/mouse/Uox/Uox-ai-review.yaml	Uox	P25688	NCBITaxon:10090	Mus musculus	31	R-MMU-9033925	Pex5l binds Acox1 or Uox	yes	reactome/R-MMU-9033925.md	Pex5l binds Acox1 or Uox	Mus musculus	GO:0005829	cytosol	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	Reactome notes Pex5l binding to Uox, but this does not establish cytosolic residence as a primary location.
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	24	R-RNO-198601	Akt1 phosphorylates GSK3	yes	reactome/R-RNO-198601.md	Akt1 phosphorylates GSK3	Rattus norvegicus	GO:0004674	protein serine/threonine kinase activity	TAS	enables	MF	false		ACCEPT	The rat ISO traces to mouse Akt1 and human AKT1. The donor annotation has experimental support and represents a conserved core kinase or PI3K/insulin-signaling function. Rat experimental annotations also exist for this term (PMID:10454575, PMID:12089343, PMID:8524413).
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	198	R-RNO-437185	PDK1 activates PKC zeta	yes	reactome/R-RNO-437185.md	PDK1 activates PKC zeta	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The rat ISO traces to mouse Akt1 and human AKT1. Donor experiments support the term, and the transfer is plausible in rat, but it reflects a contextual localization or process rather than the core evolved AKT1 function. Rat experimental annotations also exist for this term (PMID:9112399).
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	199	R-RNO-437189	PDK1 binds PKC zeta	yes	reactome/R-RNO-437189.md	PDK1 binds PKC zeta	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The rat ISO traces to mouse Akt1 and human AKT1. Donor experiments support the term, and the transfer is plausible in rat, but it reflects a contextual localization or process rather than the core evolved AKT1 function. Rat experimental annotations also exist for this term (PMID:9112399).
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	227	R-RNO-198333	Akt translocates to the nucleus	yes	reactome/R-RNO-198333.md	Akt translocates to the nucleus	Rattus norvegicus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The rat ISO traces to human AKT1. Donor experiments support the term, and the transfer is plausible in rat, but it reflects a contextual localization or process rather than the core evolved AKT1 function.
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	228	R-RNO-198333	Akt translocates to the nucleus	yes	reactome/R-RNO-198333.md	Akt translocates to the nucleus	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The rat ISO traces to mouse Akt1 and human AKT1. Donor experiments support the term, and the transfer is plausible in rat, but it reflects a contextual localization or process rather than the core evolved AKT1 function. Rat experimental annotations also exist for this term (PMID:9112399).
rat	Akt1	genes/rat/Akt1/Akt1-ai-review.yaml	Akt1	P47196	NCBITaxon:10116	Rattus norvegicus	229	R-RNO-198601	Akt1 phosphorylates GSK3	yes	reactome/R-RNO-198601.md	Akt1 phosphorylates GSK3	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The rat ISO traces to mouse Akt1 and human AKT1. Donor experiments support the term, and the transfer is plausible in rat, but it reflects a contextual localization or process rather than the core evolved AKT1 function. Rat experimental annotations also exist for this term (PMID:9112399).
rat	Araf	genes/rat/Araf/Araf-ai-review.yaml	Araf	P14056	NCBITaxon:10116	Rattus norvegicus	24	R-RNO-188339	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is retained for Araf as supported contextual biology, but it is not the defining core function (TAS, Reactome:R-RNO-188339).
rat	Ghr	genes/rat/Ghr/Ghr-ai-review.yaml	Ghr	P16310	NCBITaxon:10116	Rattus norvegicus	49	R-NUL-1169195	SOCS binding to Ghr	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for SOCS binding to GHR places the receptor at the plasma membrane. Correct.
rat	Ghr	genes/rat/Ghr/Ghr-ai-review.yaml	Ghr	P16310	NCBITaxon:10116	Rattus norvegicus	50	R-RNO-1168854	JAK2 phosphorylation of Irs-1/2	no				GO:0005886	plasma membrane	TAS	located_in	CC	false		ACCEPT	Reactome pathway for JAK2 phosphorylation of IRS-1/2 places GHR at plasma membrane. Correct.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	90	R-RNO-9625160	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	yes	reactome/R-RNO-9625160.md	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	Rattus norvegicus	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Manual review: lysosomal lumen may be context-dependent or peripheral for Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	91	R-RNO-9625173	Unfolded substrate in Lamp2 multimeric complex binds Hspa8	yes	reactome/R-RNO-9625173.md	Unfolded substrate in Lamp2 multimeric complex binds Hspa8	Rattus norvegicus	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Manual review: lysosomal lumen may be context-dependent or peripheral for Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	92	R-RNO-9626028	Hspa8:Substrate dissociates from Lamp2 multimer	yes	reactome/R-RNO-9626028.md	Hspa8:Substrate dissociates from Lamp2 multimer	Rattus norvegicus	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Manual review: lysosomal lumen may be context-dependent or peripheral for Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	94	R-RNO-9613356	Plins bind Hspa8	yes	reactome/R-RNO-9613356.md	Plins bind Hspa8	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	95	R-RNO-9615712	Hspa8 binds Rnase1	yes	reactome/R-RNO-9615712.md	Hspa8 binds Rnase1	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	96	R-RNO-9620205	Hspa8:Rnase1 binds Lamp2a	yes	reactome/R-RNO-9620205.md	Hspa8:Rnase1 binds Lamp2a	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	97	R-RNO-9622832	Hspa8 dissociates from Lamp2a-bound substrate	yes	reactome/R-RNO-9622832.md	Hspa8 dissociates from Lamp2a-bound substrate	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	98	R-RNO-9626236	Hspa8 dissociates from Lamp2	yes	reactome/R-RNO-9626236.md	Hspa8 dissociates from Lamp2	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	99	R-RNO-9626239	Hspa8 binds Lamp2 multimers	yes	reactome/R-RNO-9626239.md	Hspa8 binds Lamp2 multimers	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Hspa8	genes/rat/Hspa8/Hspa8-ai-review.yaml	Hspa8	P63018	NCBITaxon:10116	Rattus norvegicus	100	R-RNO-9626254	Hspa8:Lamp2 multimers depolymerizes to monomers	yes	reactome/R-RNO-9626254.md	Hspa8:Lamp2 multimers depolymerizes to monomers	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of Hspa8.
rat	Mapk1	genes/rat/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63086	NCBITaxon:10116	Rattus norvegicus	109	R-NUL-3245934	Mapk1 (Erk2) phosphorylates ERF	yes	reactome/R-NUL-3245934.md	Mapk1 (Erk2) phosphorylates ERF	Homo sapiens	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	Nucleoplasm localization, from a Reactome reaction (Mapk1 phosphorylates ERF). Consistent core nuclear localization.
rat	Mapk1	genes/rat/Mapk1/Mapk1-ai-review.yaml	Mapk1	P63086	NCBITaxon:10116	Rattus norvegicus	146	R-NUL-997411	AGER binds rat ERK1/2	yes	reactome/R-NUL-997411.md	AGER binds rat ERK1/2	Homo sapiens	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosolic localization from a Reactome reaction (AGER binds rat ERK1/2). Core localization.
rat	Ppp3r1	genes/rat/Ppp3r1/Ppp3r1-ai-review.yaml	Ppp3r1	P63100	NCBITaxon:10116	Rattus norvegicus	10	R-RNO-201760	Reactome pathway annotation	no				GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	cytosol is retained for Ppp3r1 as supported contextual biology, but it is not the defining core function (TAS, Reactome:R-RNO-201760).
rat	Prkaa2	genes/rat/Prkaa2/Prkaa2-ai-review.yaml	Prkaa2	Q09137	NCBITaxon:10116	Rattus norvegicus	167	R-RNO-164087	Phosphorylation of rChREBP(Ser 568) by rAMPK	yes	reactome/R-RNO-164087.md	Phosphorylation of rChREBP(Ser 568) by rAMPK	Rattus norvegicus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Reactome-derived localization - the curated rat event ""Phosphorylation of rChREBP(Ser 568) by rAMPK"" takes place in the nucleus, placing the AMPK heterotrimer in the nucleoplasm. Consistent with AMPKalpha2's nuclear localization signal, nuclear shuttling, and nuclear substrates (ChREBP, histone H2B)."
rat	Prkaa2	genes/rat/Prkaa2/Prkaa2-ai-review.yaml	Prkaa2	Q09137	NCBITaxon:10116	Rattus norvegicus	168	R-RNO-164106	rLkb-1 (Stk-11) activates AMPK by phosphorylation	yes	reactome/R-RNO-164106.md	rLkb-1 (Stk-11) activates AMPK by phosphorylation	Rattus norvegicus	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	"Reactome-derived localization - the curated rat event ""rLkb-1 (Stk-11) activates AMPK by phosphorylation"" is placed in the nucleus, locating the AMPK heterotrimer in the nucleoplasm during LKB1-mediated Thr172 activation. Consistent with AMPKalpha2 nuclear shuttling and the other accepted nucleus/nucleoplasm rows."
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	6	R-RNO-9625160	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	yes	reactome/R-RNO-9625160.md	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	Rattus norvegicus	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The lysosomal lumen annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	7	R-RNO-9626028	Hspa8:Substrate dissociates from Lamp2 multimer	yes	reactome/R-RNO-9626028.md	Hspa8:Substrate dissociates from Lamp2 multimer	Rattus norvegicus	GO:0043202	lysosomal lumen	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The lysosomal lumen annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	8	R-RNO-9615712	Hspa8 binds Rnase1	yes	reactome/R-RNO-9615712.md	Hspa8 binds Rnase1	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	9	R-RNO-9620205	Hspa8:Rnase1 binds Lamp2a	yes	reactome/R-RNO-9620205.md	Hspa8:Rnase1 binds Lamp2a	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	10	R-RNO-9622832	Hspa8 dissociates from Lamp2a-bound substrate	yes	reactome/R-RNO-9622832.md	Hspa8 dissociates from Lamp2a-bound substrate	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	11	R-RNO-9622851	Substrate:Lamp2a binds Hsp90	yes	reactome/R-RNO-9622851.md	Substrate:Lamp2a binds Hsp90	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	12	R-RNO-9624154	Substrate:Lamp2a:Hsp90 polymerizes	yes	reactome/R-RNO-9624154.md	Substrate:Lamp2a:Hsp90 polymerizes	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	13	R-RNO-9625160	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	yes	reactome/R-RNO-9625160.md	Hspa8 transports unfolded substrate to lysosomal lumen for degradation	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	14	R-RNO-9625173	Unfolded substrate in Lamp2 multimeric complex binds Hspa8	yes	reactome/R-RNO-9625173.md	Unfolded substrate in Lamp2 multimeric complex binds Hspa8	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Rnase1	genes/rat/Rnase1/Rnase1-ai-review.yaml	Rnase1	P00684	NCBITaxon:10116	Rattus norvegicus	15	R-RNO-9625183	Gfap binds Lamp2 multimer	yes	reactome/R-RNO-9625183.md	Gfap binds Lamp2 multimer	Rattus norvegicus	GO:0005829	cytosol	TAS	located_in	CC	false		KEEP_AS_NON_CORE	The cytosol annotation is plausible for Rnase1 but should be kept as non-core context rather than used to define the gene product function.
rat	Tst	genes/rat/Tst/Tst-ai-review.yaml	Tst	P24329	NCBITaxon:10116	Rattus norvegicus	9	R-RNO-1614611	Persulfide sulfur is transferred onto sulfite	no				GO:0016783	sulfurtransferase activity	TAS	enables	MF	false		KEEP_AS_NON_CORE	sulfurtransferase activity is the direct parent of the more specific GO:0004792 (thiosulfate-cyanide sulfurtransferase activity) already ACCEPTed for Tst; retained as non-core because the specific child captures the molecular function (TAS, Reactome:R-RNO-1614611).
rat	Tst	genes/rat/Tst/Tst-ai-review.yaml	Tst	P24329	NCBITaxon:10116	Rattus norvegicus	11	R-RNO-1614611	Persulfide sulfur is transferred onto sulfite	no				GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		KEEP_AS_NON_CORE	mitochondrial matrix is retained as contextual support for Tst, but it is not the core function (TAS, Reactome:R-RNO-1614611).
rat	Tst	genes/rat/Tst/Tst-ai-review.yaml	Tst	P24329	NCBITaxon:10116	Rattus norvegicus	19	R-RNO-1614611	Persulfide sulfur is transferred onto sulfite	no				GO:0070813	hydrogen sulfide metabolic process	TAS		UNKNOWN	false		NEW	NEW annotation. Tst/rhodanese is a component of the mitochondrial sulfide oxidation (H2S catabolism) pathway: sulfide:quinone oxidoreductase generates a persulfide that is processed by ETHE1 and TST, with TST transferring persulfide sulfur onto sulfite to form thiosulfate (the rat Reactome reaction R-RNO-1614611). This places Tst directly in hydrogen sulfide metabolic process, a role emphasized by current literature but absent from the existing GOA set, which captures only the cyanide-detoxification and generic sulfurtransferase aspects.
worm	atfs-1	genes/worm/atfs-1/atfs-1-ai-review.yaml	atfs-1	Q23272	NCBITaxon:6239	Caenorhabditis elegans	23	R-CEL-9856623	ATFS-1 translocates from the cytosol to the nucleoplasm	yes	reactome/R-CEL-9856623.md	ATFS-1 translocates from the cytosol to the nucleoplasm	Caenorhabditis elegans	GO:0005654	nucleoplasm	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway annotation. ATFS-1 translocates from cytosol to nucleoplasm during UPRmt activation.
worm	atfs-1	genes/worm/atfs-1/atfs-1-ai-review.yaml	atfs-1	Q23272	NCBITaxon:6239	Caenorhabditis elegans	24	R-CEL-9856612	ATFS-1 translocates from the cytosol to the mitochondrial matrix	yes	reactome/R-CEL-9856612.md	ATFS-1 translocates from the cytosol to the mitochondrial matrix	Caenorhabditis elegans	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome pathway. ATFS-1 is imported to the mitochondrial matrix under normal conditions.
worm	atfs-1	genes/worm/atfs-1/atfs-1-ai-review.yaml	atfs-1	Q23272	NCBITaxon:6239	Caenorhabditis elegans	25	R-CEL-9856612	ATFS-1 translocates from the cytosol to the mitochondrial matrix	yes	reactome/R-CEL-9856612.md	ATFS-1 translocates from the cytosol to the mitochondrial matrix	Caenorhabditis elegans	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. ATFS-1 transits through cytosol before mitochondrial import.
worm	atfs-1	genes/worm/atfs-1/atfs-1-ai-review.yaml	atfs-1	Q23272	NCBITaxon:6239	Caenorhabditis elegans	26	R-CEL-9856623	ATFS-1 translocates from the cytosol to the nucleoplasm	yes	reactome/R-CEL-9856623.md	ATFS-1 translocates from the cytosol to the nucleoplasm	Caenorhabditis elegans	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	TAS annotation from Reactome. ATFS-1 accumulates in cytosol during stress before nuclear translocation.
yeast	CMC2	genes/yeast/CMC2/CMC2-ai-review.yaml	CMC2	Q3E7A4	NCBITaxon:559292	Saccharomyces cerevisiae	9	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome traceable author statement placing Cmc2 in the intermembrane space.
yeast	COA4	genes/yeast/COA4/COA4-ai-review.yaml	COA4	Q05809	NCBITaxon:559292	Saccharomyces cerevisiae	9	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome traceable-author-statement placing Coa4 in the intermembrane space, agreeing with the direct experimental evidence.
yeast	COX17	genes/yeast/COX17/COX17-ai-review.yaml	COX17	Q12287	NCBITaxon:559292	Saccharomyces cerevisiae	9	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome traceable author statement placing Cox17 in the intermembrane space.
yeast	COX19	genes/yeast/COX19/COX19-ai-review.yaml	COX19	Q3E731	NCBITaxon:559292	Saccharomyces cerevisiae	12	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	Reactome traceable author statement placing Cox19 in the intermembrane space.
yeast	GET3	genes/yeast/GET3/GET3-ai-review.yaml	GET3	Q12154	NCBITaxon:559292	Saccharomyces cerevisiae	43	R-SCE-9628646	SBH1:GET3:ADP binds GET1:GET2	yes	reactome/R-SCE-9628646.md	SBH1:GET3:ADP binds GET1:GET2	Saccharomyces cerevisiae	GO:0016887	ATP hydrolysis activity	TAS	enables	MF	false		ACCEPT	Manual review: ATP hydrolysis activity is consistent with known biology of GET3.
yeast	GET3	genes/yeast/GET3/GET3-ai-review.yaml	GET3	Q12154	NCBITaxon:559292	Saccharomyces cerevisiae	50	R-SCE-9628640	SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane	yes	reactome/R-SCE-9628640.md	SBH1:GET3:ADP:GET1:GET2 dissociates yielding SBH1 in the endoplasmic reticulum membrane	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of GET3.
yeast	GET3	genes/yeast/GET3/GET3-ai-review.yaml	GET3	Q12154	NCBITaxon:559292	Saccharomyces cerevisiae	51	R-SCE-9628646	SBH1:GET3:ADP binds GET1:GET2	yes	reactome/R-SCE-9628646.md	SBH1:GET3:ADP binds GET1:GET2	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of GET3.
yeast	GET3	genes/yeast/GET3/GET3-ai-review.yaml	GET3	Q12154	NCBITaxon:559292	Saccharomyces cerevisiae	52	R-SCE-9629050	SBH1:GET3:ATP:GET4:MDY2:SGT2 dissociates and GET3 hydrolyzes ATP yielding SBH1:GET3:ADP	yes	reactome/R-SCE-9629050.md	SBH1:GET3:ATP:GET4:MDY2:SGT2 dissociates and GET3 hydrolyzes ATP yielding SBH1:GET3:ADP	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Manual review: cytosol is consistent with known biology of GET3.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	41	R-SCE-1252253	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix	yes	reactome/R-SCE-1252253.md	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix	Saccharomyces cerevisiae	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation based on TIM23 PAM complex translocation pathway. HSP60 participates in this process but is primarily a matrix protein.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	42	R-SCE-1268014	Precursor proteins enter TIM23 PAM complex	yes	reactome/R-SCE-1268014.md	Precursor proteins enter TIM23 PAM complex	Saccharomyces cerevisiae	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for precursor protein entry into TIM23 PAM complex. Same rationale as above.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	43	R-SCE-1268017	MPP hydrolyzes presequence of matrix precursors	yes	reactome/R-SCE-1268017.md	MPP hydrolyzes presequence of matrix precursors	Saccharomyces cerevisiae	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		KEEP_AS_NON_CORE	Reactome annotation for MPP presequence hydrolysis. Same rationale.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	44	R-SCE-1252255	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	yes	reactome/R-SCE-1252255.md	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		REMOVE	Reactome annotation suggesting HSP60 is in the intermembrane space during the TOM40/TOM70 translocation process. HSP60 is not a resident IMS protein; it participates in protein import that transits the IMS.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	45	R-SCE-1268014	Precursor proteins enter TIM23 PAM complex	yes	reactome/R-SCE-1268014.md	Precursor proteins enter TIM23 PAM complex	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		REMOVE	Same rationale as above. HSP60 is a matrix protein, not an IMS resident.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	46	R-SCE-1252253	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix	yes	reactome/R-SCE-1252253.md	TIM23 PAM complex translocates proteins from the mitochondrial intermembrane space to the mitochondrial matrix	Saccharomyces cerevisiae	GO:0005759	mitochondrial matrix	TAS	located_in	CC	false		ACCEPT	Reactome annotation consistent with known matrix localization.
yeast	HSP60	genes/yeast/HSP60/HSP60-ai-review.yaml	HSP60	P19882	NCBITaxon:559292	Saccharomyces cerevisiae S288C	47	R-SCE-1252255	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	yes	reactome/R-SCE-1252255.md	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	Reactome annotation. HSP60 is synthesized in the cytosol but is rapidly imported into mitochondria. The cytosol is not where HSP60 functions.
yeast	IRE1	genes/yeast/IRE1/IRE1-ai-review.yaml	IRE1	P32361	NCBITaxon:559292	Saccharomyces cerevisiae	36	R-SCE-535524	Phosphorylated Ire1 Dimer Binds ADP	yes	reactome/R-SCE-535524.md	Phosphorylated Ire1 Dimer Binds ADP	Saccharomyces cerevisiae	GO:0005789	endoplasmic reticulum membrane	TAS	located_in	CC	false		ACCEPT	TAS annotation for ER membrane from Reactome pathway.
yeast	ORC1	genes/yeast/ORC1/ORC1-ai-review.yaml	ORC1	P54784	NCBITaxon:559292	Saccharomyces cerevisiae	27	R-SCE-9749345	CDT1-mediated loading of MCM2-7 to replication origin in budding yeast	yes	reactome/R-SCE-9749345.md	CDT1-mediated loading of MCM2-7 to replication origin in budding yeast	Saccharomyces cerevisiae	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome identifies nucleoplasm as the functional compartment for MCM loading.
yeast	ORC1	genes/yeast/ORC1/ORC1-ai-review.yaml	ORC1	P54784	NCBITaxon:559292	Saccharomyces cerevisiae	28	R-SCE-9749381	ATP-dependent release of CDT1 from the OCCM complex in budding yeast	yes	reactome/R-SCE-9749381.md	ATP-dependent release of CDT1 from the OCCM complex in budding yeast	Saccharomyces cerevisiae	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome pathway identifies nucleoplasm localization during CDT1 release.
yeast	ORC1	genes/yeast/ORC1/ORC1-ai-review.yaml	ORC1	P54784	NCBITaxon:559292	Saccharomyces cerevisiae	29	R-SCE-9749401	CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast	yes	reactome/R-SCE-9749401.md	CTD1-mediated formation of MCM2-7 double hexamers at the replication origins in budding yeast	Saccharomyces cerevisiae	GO:0005654	nucleoplasm	TAS	located_in	CC	false		KEEP_AS_NON_CORE	TAS annotation from Reactome identifies nucleoplasm during MCM double hexamer formation.
yeast	SUI2	genes/yeast/SUI2/SUI2-ai-review.yaml	SUI2	P20459	NCBITaxon:559292	Saccharomyces cerevisiae	31	R-SCE-9633480	GCN2 phosphorylates SUI2	yes	reactome/R-SCE-9633480.md	GCN2 phosphorylates SUI2	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		ACCEPT	Cytosol localization from Reactome curated pathway for GCN2 phosphorylation of eIF2α. TAS (Traced to Authoritative Source) indicates this comes from a high-quality curated database. This duplicates the IEA cytosol annotation already provided.
yeast	TIM10	genes/yeast/TIM10/TIM10-ai-review.yaml	TIM10	P87108	NCBITaxon:559292	Saccharomyces cerevisiae	22	R-SCE-9839836	YME1 degrades TIM10	yes	reactome/R-SCE-9839836.md	YME1 degrades TIM10	Saccharomyces cerevisiae	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"This Reactome annotation refers to the reaction ""YME1 degrades TIM10"", indicating TIM10 is located at the mitochondrial inner membrane where it can be degraded by the i-AAA protease YME1. TIM10 association with the inner membrane is well established."
yeast	TIM10	genes/yeast/TIM10/TIM10-ai-review.yaml	TIM10	P87108	NCBITaxon:559292	Saccharomyces cerevisiae	24	R-SCE-1252259	TIM9:TIM10 binds hydrophobic proteins	yes	reactome/R-SCE-1252259.md	TIM9:TIM10 binds hydrophobic proteins	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	"This Reactome annotation references the reaction ""TIM9:TIM10 binds hydrophobic proteins"" in the IMS. This is consistent with the known function of the TIM9-TIM10 complex as a soluble IMS chaperone."
yeast	TIM10	genes/yeast/TIM10/TIM10-ai-review.yaml	TIM10	P87108	NCBITaxon:559292	Saccharomyces cerevisiae	25	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	"This Reactome annotation references the reaction ""MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds"", referring to the Mia40/Erv1 disulfide relay pathway that imports and oxidizes small TIM proteins like TIM10 in the IMS."
yeast	TIM22	genes/yeast/TIM22/TIM22-ai-review.yaml	TIM22	Q12328	NCBITaxon:559292	Saccharomyces cerevisiae	27	R-SCE-1252258	TIM22 complex inserts proteins into inner membrane	yes	reactome/R-SCE-1252258.md	TIM22 complex inserts proteins into inner membrane	Saccharomyces cerevisiae	GO:0005743	mitochondrial inner membrane	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway R-SCE-1252258 ""TIM22 complex inserts proteins into inner membrane."" TIM22 is indeed located in the inner membrane."
yeast	TIM22	genes/yeast/TIM22/TIM22-ai-review.yaml	TIM22	Q12328	NCBITaxon:559292	Saccharomyces cerevisiae	28	R-SCE-1252255	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	yes	reactome/R-SCE-1252255.md	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"TAS annotation from Reactome pathway R-SCE-1252255 ""TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space."" This Reactome pathway describes the TOM-mediated import step, not TIM22 function per se. TIM22 does have domains exposed to the IMS (the N-terminal and C-terminal regions per UniProt topology), so there is some basis for IMS localization, but the primary localization is the inner membrane itself. This appears to be a Reactome annotation associating TIM22 with a pathway step where it is a participant rather than indicating its primary localization."
yeast	TIM22	genes/yeast/TIM22/TIM22-ai-review.yaml	TIM22	Q12328	NCBITaxon:559292	Saccharomyces cerevisiae	29	R-SCE-1252258	TIM22 complex inserts proteins into inner membrane	yes	reactome/R-SCE-1252258.md	TIM22 complex inserts proteins into inner membrane	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"TAS annotation from Reactome pathway R-SCE-1252258 ""TIM22 complex inserts proteins into inner membrane."" Same concern as the other IMS annotation -- TIM22 is an integral inner membrane protein with IMS-exposed domains, but its primary CC is the inner membrane."
yeast	TIM22	genes/yeast/TIM22/TIM22-ai-review.yaml	TIM22	Q12328	NCBITaxon:559292	Saccharomyces cerevisiae	30	R-SCE-1252259	TIM9:TIM10 binds hydrophobic proteins	yes	reactome/R-SCE-1252259.md	TIM9:TIM10 binds hydrophobic proteins	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		MARK_AS_OVER_ANNOTATED	"TAS annotation from Reactome pathway R-SCE-1252259 ""TIM9:TIM10 binds hydrophobic proteins."" This pathway describes the action of the small TIM chaperones (Tim9-Tim10) in the IMS, not TIM22 itself. TIM22 is listed as a participant in the broader mitochondrial import pathway but its primary localization is the inner membrane."
yeast	TIM22	genes/yeast/TIM22/TIM22-ai-review.yaml	TIM22	Q12328	NCBITaxon:559292	Saccharomyces cerevisiae	31	R-SCE-1252255	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	yes	reactome/R-SCE-1252255.md	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	Saccharomyces cerevisiae	GO:0005829	cytosol	TAS	located_in	CC	false		REMOVE	TAS annotation from Reactome pathway R-SCE-1252255. This likely reflects that TIM22 precursor protein passes through the cytosol during its own import. However, mature TIM22 is an integral inner membrane protein and is not a cytosolic protein.
yeast	TIM9	genes/yeast/TIM9/TIM9-ai-review.yaml	TIM9	O74700	NCBITaxon:559292	Saccharomyces cerevisiae	16	R-SCE-1252259	TIM9:TIM10 binds hydrophobic proteins	yes	reactome/R-SCE-1252259.md	TIM9:TIM10 binds hydrophobic proteins	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""TIM9:TIM10 binds hydrophobic proteins."" The IMS localization is consistent with all experimental evidence."
yeast	TIM9	genes/yeast/TIM9/TIM9-ai-review.yaml	TIM9	O74700	NCBITaxon:559292	Saccharomyces cerevisiae	17	R-SCE-1252260	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	yes	reactome/R-SCE-1252260.md	MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds	Saccharomyces cerevisiae	GO:0005758	mitochondrial intermembrane space	TAS	located_in	CC	false		ACCEPT	"TAS annotation from Reactome pathway ""MIA40:ERV1 oxidizes cysteine residues to cystine disulfide bonds."" This Reactome entry relates to the MIA pathway by which TIM9 is imported and oxidized in the IMS. The IMS localization is correct."
yeast	TOM22	genes/yeast/TOM22/TOM22-ai-review.yaml	TOM22	P49334	NCBITaxon:559292	Saccharomyces cerevisiae	30	R-SCE-1252255	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	yes	reactome/R-SCE-1252255.md	TOM40:TOM70 complex translocates proteins from the cytosol to the mitochondrial intermembrane space	Saccharomyces cerevisiae	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct. Tom22 is an outer mitochondrial membrane component of the TOM complex.
yeast	TOM22	genes/yeast/TOM22/TOM22-ai-review.yaml	TOM22	P49334	NCBITaxon:559292	Saccharomyces cerevisiae	31	R-SCE-8953627	Formation of MIB complex containing the MICOS complex	yes	reactome/R-SCE-8953627.md	Formation of MIB complex containing the MICOS complex	Saccharomyces cerevisiae	GO:0005741	mitochondrial outer membrane	TAS	located_in	CC	false		ACCEPT	Correct. Tom22 in the MIB context is still anchored in the mitochondrial outer membrane.