gene_product gene_label model_id model_title taxon activity_id molecular_function mf_label biological_process bp_label cellular_component cc_label in_reactome_module matching_modules UniProtKB:Q9NYG2 ZDHHC3 Hsap 586fc17a00000528 PRCD-human-retinitis pigmentosa NCBITaxon:9606 gomodel:586fc17a00000528/586fc17a00000530 GO:0016409 palmitoyltransferase activity GO:0018345 protein palmitoylation GO:0005794 Golgi apparatus false UniProtKB:Q00LT1 PRCD Hsap 586fc17a00000528 PRCD-human-retinitis pigmentosa NCBITaxon:9606 gomodel:586fc17a00000528/586fc17a00000544 GO:0003674 molecular_function GO:0050908 detection of light stimulus involved in visual perception UBERON:0003926 photoreceptor outer segment layer false UniProtKB:P01584 IL1B Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/59cc772c00000002 GO:0005125 cytokine activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P14778 IL1R1 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/59cc772c00000006 GO:0004908 interleukin-1 receptor activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P51617 IRAK1 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/59cc772c00000024 GO:0016301 kinase activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q99836 MYD88 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/59cc772c00000026 GO:0060090 molecular adaptor activity GO:0070498 interleukin-1-mediated signaling pathway GO:0019897 extrinsic component of plasma membrane false UniProtKB:O43318 MAP3K7 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/59cde02c00000027 GO:0016301 kinase activity GO:0005737 cytoplasm false UniProtKB:P29466 CASP1 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/626b20c100001883 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:Q9NPH3 IL1RAP Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/626b20c100001910 GO:0015026 coreceptor activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9H0E2 TOLLIP Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/626b20c100001914 GO:0060090 molecular adaptor activity GO:0070498 interleukin-1-mediated signaling pathway GO:0019897 extrinsic component of plasma membrane false UniProtKB:Q9NWZ3 IRAK4 Hsap 59cc772c00000000 IL1beta-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:59cc772c00000000/626b20c100002005 GO:0016301 kinase activity GO:0070498 interleukin-1-mediated signaling pathway GO:0019897 extrinsic component of plasma membrane false UniProtKB:P01225 FSHB Hsap 59dc728000000351 GPCR - AC activating NCBITaxon:9606 gomodel:59dc728000000351/59dc728000000353 GO:0016913 follicle-stimulating hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P23945 FSHR Hsap 59dc728000000351 GPCR - AC activating NCBITaxon:9606 gomodel:59dc728000000351/59dc728000000356 GO:0004963 follicle-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q5JWF2 GNAS Hsap 59dc728000000351 GPCR - AC activating NCBITaxon:9606 gomodel:59dc728000000351/59dc728000000359 GO:0010856 adenylate cyclase activator activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q08828 ADCY1 Hsap 59dc728000000351 GPCR - AC activating NCBITaxon:9606 gomodel:59dc728000000351/59dc728000000362 GO:0004016 adenylate cyclase activity GO:0006171 cAMP biosynthetic process GO:0005886 plasma membrane false UniProtKB:Q9BYX4 IFIH1 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004020 GO:0038187 pattern recognition receptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:O95786-2 RIGI Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004027 GO:0038187 pattern recognition receptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q7Z434-1 MAVS Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004043 GO:0035591 signaling adaptor activity GO:0140374 antiviral innate immune response GO:0031966 mitochondrial membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004048 GO:0061630 ubiquitin protein ligase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q13114-2 TRAF3 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004053 GO:0061630 ubiquitin protein ligase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004060 GO:0004674 protein serine/threonine kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q14653-5 IRF3 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004068 GO:0003700 DNA-binding transcription factor activity GO:0009299 mRNA transcription GO:0005634 nucleus false UniProtKB:Q14258 TRIM25 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004104 GO:0061630 ubiquitin protein ligase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P0DTC9 N protein Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004111 GO:0140311 protein sequestering activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P0DTD2 ORF9b Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5e72450500004217 GO:0140311 protein sequestering activity GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity GO:0031966 mitochondrial membrane false UniProtKB:P0DTD1-PRO_0000449619 nsp1 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/5ee8120100000947 GO:0030371 translation repressor activity GO:0039606 symbiont-mediated suppression of host translation initiation false UniProtKB:P0DTC5 M protein Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000021 GO:0140311 protein sequestering activity GO:0039545 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity false UniProtKB:P0DTD1-PRO_0000449621 nsp3 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000038 GO:0019785 ISG15-specific peptidase activity GO:0005737 cytoplasm false UniProtKB:P0DTD1-PRO_0000449624 nsp6 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000046 GO:0140311 protein sequestering activity GO:0005737 cytoplasm false UniProtKB:P0DTD1-PRO_0000449630 nsp13 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000055 GO:0140311 protein sequestering activity GO:0005737 cytoplasm false UniProtKB:P0DTD1-PRO_0000449621 nsp3 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000068 GO:0019785 ISG15-specific peptidase activity GO:0005737 cytoplasm false UniProtKB:P0DTD1-PRO_0000449629 nsp12 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000078 GO:0140311 protein sequestering activity GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity GO:0005737 cytoplasm false UniProtKB:P0DTD1-PRO_0000449619 nsp1 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000087 GO:0140311 protein sequestering activity GO:0039522 symbiont-mediated suppression of host mRNA export from nucleus GO:0005634 nucleus false UniProtKB:P0DTD1-PRO_0000449633 nsp16 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000109 GO:0003723 RNA binding GO:0046780 symbiont-mediated suppression of host mRNA splicing GO:0005634 nucleus false UniProtKB:O94826 TOMM70 Hsap 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/6086f4f200000207 GO:0030674 protein-macromolecule adaptor activity GO:0031966 mitochondrial membrane false UniProtKB:P0DTC6 ORF6 Scov2 5e72450500004019 SARS-COV2/HOST NCBITaxon:9606 gomodel:5e72450500004019/63d320cd00001659 GO:0140311 protein sequestering activity GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity GO:0031965 nuclear membrane false UniProtKB:Q7Z434 MAVS Hsap 5ee8120100000524 SP_N4BP3on MAVS NCBITaxon:9606 gomodel:5ee8120100000524/61e0e55600000371 GO:0035591 signaling adaptor activity false UniProtKB:O15049 N4BP3 Hsap 5ee8120100000524 SP_N4BP3on MAVS NCBITaxon:9606 gomodel:5ee8120100000524/61e0e55600000374 GO:0005515 protein binding false UniProtKB:P46934 NEDD4 Hsap 5ee8120100000524 SP_N4BP3on MAVS NCBITaxon:9606 gomodel:5ee8120100000524/61e0e55600000377 GO:0061630 ubiquitin protein ligase activity false UniProtKB:Q12933 TRAF2 Hsap 5ee8120100000524 SP_N4BP3on MAVS NCBITaxon:9606 gomodel:5ee8120100000524/61e0e55600000391 GO:0031625 ubiquitin protein ligase binding false UniProtKB:P18428 LBP Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/5f46c3b700001032 GO:0140104 molecular carrier activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005576 extracellular region false UniProtKB:P08571 CD14 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/5f46c3b700001036 GO:0140104 molecular carrier activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005576 extracellular region false UniProtKB:O00206 TLR4 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/5f46c3b700001223 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99836 MYD88 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/5f46c3b700001250 GO:0035591 signaling adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P58753 TIRAP Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/5f46c3b700001254 GO:0035591 signaling adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9NWZ3 IRAK4 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000007 GO:0004674 protein serine/threonine kinase activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:O43187 IRAK2 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000019 GO:0035591 signaling adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000029 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9BQ95 ECSIT Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000043 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000056 GO:0004674 protein serine/threonine kinase activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:O15111 CHUK Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000074 GO:0008384 IkappaB kinase activity GO:0038061 non-canonical NF-kappaB signal transduction false UniProtKB:Q04206 RELA Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000086 GO:0003700 DNA-binding transcription factor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:P25963 NFKBIA Hsap 5f46c3b700001031 MYD88-dependent TLR4 signaling pathway leading to NF-kappa-B activation (Human) NCBITaxon:9606 gomodel:5f46c3b700001031/6413ac9800000096 GO:0140313 molecular sequestering activity GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q13114 TRAF3 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001408 GO:0061630 ubiquitin protein ligase activity GO:0032481 positive regulation of type I interferon production GO:0005768 endosome false UniProtKB:Q8IUC6 TICAM1 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001412 GO:0060090 molecular adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005768 endosome false UniProtKB:Q86XR7 TICAM2 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001416 GO:0060090 molecular adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005768 endosome false UniProtKB:Q9UHD2 TBK1 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001423 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001429 GO:0060090 molecular adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005739 mitochondrion false UniProtKB:Q13114 TRAF3 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/5f46c3b700001437 GO:0061630 ubiquitin protein ligase activity GO:0032481 positive regulation of type I interferon production GO:0005739 mitochondrion false UniProtKB:Q9Y228 TRAF3IP3 Hsap 5f46c3b700001407 TBK1 activation via TRAF3 autoubiquitination (Human) NCBITaxon:9606 gomodel:5f46c3b700001407/633b013300001697 GO:0060090 molecular adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005739 mitochondrion false UniProtKB:Q9UHD2 TBK1 Hsap 5f46c3b700001570 SPModule TBK1-IRF3 NCBITaxon:9606 gomodel:5f46c3b700001570/5f46c3b700001571 GO:0004674 protein serine/threonine kinase activity GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 5f46c3b700001570 SPModule TBK1-IRF3 NCBITaxon:9606 gomodel:5f46c3b700001570/5f46c3b700001577 GO:0042803 protein homodimerization activity GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 5f46c3b700001570 SPModule TBK1-IRF3 NCBITaxon:9606 gomodel:5f46c3b700001570/5f46c3b700001579 GO:0043565 sequence-specific DNA binding GO:0005634 nucleus false UniProtKB:Q14653 IRF3 Hsap 5f46c3b700001570 SPModule TBK1-IRF3 NCBITaxon:9606 gomodel:5f46c3b700001570/5f46c3b700001582 GO:0001216 DNA-binding transcription activator activity GO:0005634 nucleus false UniProtKB:Q14653 IRF3 Hsap 5f46c3b700001570 SPModule TBK1-IRF3 NCBITaxon:9606 gomodel:5f46c3b700001570/5f46c3b700001598 GO:0005515 protein binding GO:0005634 nucleus false UniProtKB:P58753 TIRAP Hsap 5f46c3b700002102 SPModule-TIRAP-MYDDOSOME NCBITaxon:9606 gomodel:5f46c3b700002102/5f46c3b700002103 GO:0060090 molecular adaptor activity GO:0009986 cell surface false UniProtKB:Q99836 MYD88 Hsap 5f46c3b700002102 SPModule-TIRAP-MYDDOSOME NCBITaxon:9606 gomodel:5f46c3b700002102/5f46c3b700002107 GO:0060090 molecular adaptor activity GO:0009986 cell surface false UniProtKB:Q9NWZ3 IRAK4 Hsap 5f46c3b700002102 SPModule-TIRAP-MYDDOSOME NCBITaxon:9606 gomodel:5f46c3b700002102/5f46c3b700002109 GO:0016301 kinase activity GO:0009986 cell surface false UniProtKB:Q9Y4K3 TRAF6 Hsap 5f46c3b700002102 SPModule-TIRAP-MYDDOSOME NCBITaxon:9606 gomodel:5f46c3b700002102/5f46c3b700002125 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0005737 cytoplasm false UniProtKB:P51617 IRAK1 Hsap 5f46c3b700002102 SPModule-TIRAP-MYDDOSOME NCBITaxon:9606 gomodel:5f46c3b700002102/5f46c3b700002131 GO:0016301 kinase activity GO:0009986 cell surface false UniProtKB:P05231 IL6 Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5f46c3b700002702 GO:0005125 cytokine activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P23458 JAK1 Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5f46c3b700002801 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5f46c3b700002806 GO:0003700 DNA-binding transcription factor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:O14543 SOCS3 Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5f46c3b700002821 GO:0004860 protein kinase inhibitor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P08887-2 IL6R Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5fce9b7300000149 GO:0004915 interleukin-6 receptor activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 5f46c3b700002685 IL6:sIL6R Trans-signaling pathway (Human) NCBITaxon:9606 gomodel:5f46c3b700002685/5fce9b7300000154 GO:0015026 coreceptor activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9BYX4 IFIH1 Hsap 5fadbcf000001101 SPModule IFIH1-MAVS NCBITaxon:9606 gomodel:5fadbcf000001101/5fadbcf000001111 GO:0038187 pattern recognition receptor activity false UniProtKB:P62136 PPP1CA Hsap 5fadbcf000001101 SPModule IFIH1-MAVS NCBITaxon:9606 gomodel:5fadbcf000001101/5fadbcf000001163 GO:0016791 phosphatase activity GO:0005737 cytoplasm false UniProtKB:Q9BYX4 IFIH1 Hsap 5fadbcf000001101 SPModule IFIH1-MAVS NCBITaxon:9606 gomodel:5fadbcf000001101/5fadbcf000001312 GO:0042802 identical protein binding GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 5fadbcf000001101 SPModule IFIH1-MAVS NCBITaxon:9606 gomodel:5fadbcf000001101/5fadbcf000001358 GO:0042802 identical protein binding GO:0005741 mitochondrial outer membrane false UniProtKB:Q7Z434 MAVS Hsap 5fadbcf000001101 SPModule IFIH1-MAVS NCBITaxon:9606 gomodel:5fadbcf000001101/5fadbcf000001369 GO:0035591 signaling adaptor activity GO:0005741 mitochondrial outer membrane false UniProtKB:Q9H0K1 SIK2 Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700000045 GO:0004674 protein serine/threonine kinase activity false UniProtKB:Q09472 EP300 Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700000048 GO:0016407 acetyltransferase activity GO:0000785 chromatin false UniProtKB:Q9NP71 MLXIPL Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700000050 GO:0001216 DNA-binding transcription activator activity GO:0008610 lipid biosynthetic process GO:0000785 chromatin false UniProtKB:Q9NP71 MLXIPL Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700000055 GO:0140297 DNA-binding transcription factor binding GO:0000785 chromatin false UniProtKB:Q09472 EP300 Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700001265 GO:0005515 protein binding false UniProtKB:Q07869 PPARA Hsap 5fadbcf000001646 SP_SIK2-actvity-on-P300 NCBITaxon:9606 gomodel:5fadbcf000001646/6197061700001271 GO:0001216 DNA-binding transcription activator activity false UniProtKB:P05231 IL6 Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000001963 GO:0005125 cytokine activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P08887-1 IL6R Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000001970 GO:0004915 interleukin-6 receptor activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P40189 IL6ST Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000001985 GO:0015026 coreceptor activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000001990 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000001997 GO:0003700 DNA-binding transcription factor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:O14543 SOCS3 Hsap 5fadbcf000001962 T-helper 17 cell lineage commitment by IL6 cluster (Human) NCBITaxon:9606 gomodel:5fadbcf000001962/5fadbcf000002007 GO:0019210 kinase inhibitor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005829 cytosol false UniProtKB:P17405 SMPD1 Hsap 5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:5fadbcf000002129/5fadbcf000002138 GO:0004767 sphingomyelin phosphodiesterase activity GO:0046513 ceramide biosynthetic process GO:0005576 extracellular region true glycosphingolipid_lysosomal_degradation UniProtKB:P17405 SMPD1 Hsap 5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:5fadbcf000002129/6246724f00001961 GO:0004767 sphingomyelin phosphodiesterase activity GO:0046513 ceramide biosynthetic process true glycosphingolipid_lysosomal_degradation UniProtKB:P17405 SMPD1 Hsap 5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:5fadbcf000002129/6246724f00001975 GO:0004767 sphingomyelin phosphodiesterase activity GO:0046513 ceramide biosynthetic process GO:0005764 lysosome true glycosphingolipid_lysosomal_degradation UniProtKB:P61916 NPC2 Hsap 5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:5fadbcf000002129/6246724f00001983 GO:0120020 cholesterol transfer activity GO:0033344 cholesterol efflux GO:0005764 lysosome false UniProtKB:Q9BYF1 ACE2 Hsap 5fadbcf000002129 Sphingomyelin phosphodiesterase activity involved in viral entry (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:5fadbcf000002129/6246724f00002005 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0005886 plasma membrane false UniProtKB:P18428 LBP Hsap 5fb9cc0600000727 Triacyl lipopetide activation of TLR1-TLR2 complex (Human) NCBITaxon:9606 gomodel:5fb9cc0600000727/5fce9b7300000008 GO:0140104 molecular carrier activity GO:0005576 extracellular region false UniProtKB:P08571 CD14 Hsap 5fb9cc0600000727 Triacyl lipopetide activation of TLR1-TLR2 complex (Human) NCBITaxon:9606 gomodel:5fb9cc0600000727/5fce9b7300000012 GO:0140104 molecular carrier activity GO:0005576 extracellular region false GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex 5fb9cc0600000727 Triacyl lipopetide activation of TLR1-TLR2 complex (Human) NCBITaxon:9606 gomodel:5fb9cc0600000727/663d668500002682 GO:0001875 lipopolysaccharide immune receptor activity GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway GO:0044853 plasma membrane raft false UniProtKB:P58753 TIRAP Hsap 5fb9cc0600000727 Triacyl lipopetide activation of TLR1-TLR2 complex (Human) NCBITaxon:9606 gomodel:5fb9cc0600000727/663d668500002710 GO:0030674 protein-macromolecule adaptor activity GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99836 MYD88 Hsap 5fce9b7300000030 Diacyl lipopeptide and bacteriocin activation of TLR6_TLR2 receptor (Human) NCBITaxon:9606 gomodel:5fce9b7300000030/5fce9b7300000098 GO:0035591 signaling adaptor activity GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway GO:0005886 plasma membrane false GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex 5fce9b7300000030 Diacyl lipopeptide and bacteriocin activation of TLR6_TLR2 receptor (Human) NCBITaxon:9606 gomodel:5fce9b7300000030/663d668500002718 GO:0001875 lipopolysaccharide immune receptor activity GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q04206 RELA Hsap 5fce9b7300000030 Diacyl lipopeptide and bacteriocin activation of TLR6_TLR2 receptor (Human) NCBITaxon:9606 gomodel:5fce9b7300000030/663d668500002749 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway GO:0000785 chromatin false UniProtKB:O75594 PGLYRP1 Hsap 5fce9b7300001590 SPModule-PGLYRP1/HSP701A NCBITaxon:9606 gomodel:5fce9b7300001590/5fce9b7300001591 GO:0030544 Hsp70 protein binding GO:0005576 extracellular region false UniProtKB:P0DMV8 HSPA1A Hsap 5fce9b7300001590 SPModule-PGLYRP1/HSP701A NCBITaxon:9606 gomodel:5fce9b7300001590/5fce9b7300001594 GO:0048018 receptor ligand activity GO:0005576 extracellular region false UniProtKB:Q9NZL4 HSPBP1 Hsap 5fce9b7300001590 SPModule-PGLYRP1/HSP701A NCBITaxon:9606 gomodel:5fce9b7300001590/5fce9b7300001597 GO:0140313 molecular sequestering activity GO:0005576 extracellular region false UniProtKB:P19438-1 TNFRSF1A Hsap 5fce9b7300001590 SPModule-PGLYRP1/HSP701A NCBITaxon:9606 gomodel:5fce9b7300001590/5fce9b7300001600 GO:0005031 tumor necrosis factor receptor activity GO:0009986 cell surface false UniProtKB:O75594 PGLYRP1 Hsap 5fce9b7300001616 SPModule-PGRP1-S100A4 NCBITaxon:9606 gomodel:5fce9b7300001616/5fce9b7300001617 GO:0060090 molecular adaptor activity GO:0005576 extracellular region false UniProtKB:P26447 S100A4 Hsap 5fce9b7300001616 SPModule-PGRP1-S100A4 NCBITaxon:9606 gomodel:5fce9b7300001616/5fce9b7300001620 GO:0042056 chemoattractant activity GO:0005576 extracellular region false UniProtKB:P49682 CXCR3 Hsap 5fce9b7300001616 SPModule-PGRP1-S100A4 NCBITaxon:9606 gomodel:5fce9b7300001616/5fce9b7300001632 GO:0016493 C-C chemokine receptor activity GO:0009986 cell surface false UniProtKB:P51681 CCR5 Hsap 5fce9b7300001616 SPModule-PGRP1-S100A4 NCBITaxon:9606 gomodel:5fce9b7300001616/5fce9b7300001638 GO:0016493 C-C chemokine receptor activity GO:0009986 cell surface false UniProtKB:Q9NP99 TREM1 Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002337 GO:0004888 transmembrane signaling receptor activity GO:0009986 cell surface false UniProtKB:O75594 PGLYRP1 Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002340 GO:0048018 receptor ligand activity GO:0005576 extracellular region false UniProtKB:P09429 HMGB1 Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002343 GO:0048018 receptor ligand activity GO:0005576 extracellular region false UniProtKB:P0DMV8 HSPA1A Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002346 GO:0048018 receptor ligand activity GO:0005576 extracellular region false UniProtKB:P43405 SYK Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002367 GO:0016301 kinase activity false UniProtKB:O43914 TYROBP Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002369 GO:0060090 molecular adaptor activity GO:0009986 cell surface false UniProtKB:Q9NP99-2 TREM1 Hsap 5fce9b7300002336 SPModule-TREM1-DAP12 NCBITaxon:9606 gomodel:5fce9b7300002336/5fce9b7300002425 GO:0140319 receptor decoy activity GO:0005576 extracellular region false UniProtKB:P05067 APP Hsap 5fce9b7300002436 TREM2 activated by APP NCBITaxon:9606 gomodel:5fce9b7300002436/5fce9b7300002443 GO:0048018 receptor ligand activity GO:1904646 cellular response to amyloid-beta GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 5fce9b7300002436 TREM2 activated by APP NCBITaxon:9606 gomodel:5fce9b7300002436/6606056e00000823 GO:0004888 transmembrane signaling receptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 5fce9b7300002436 TREM2 activated by APP NCBITaxon:9606 gomodel:5fce9b7300002436/6606056e00000837 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 5fce9b7300002436 TREM2 activated by APP NCBITaxon:9606 gomodel:5fce9b7300002436/6606056e00000849 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:Q9UK05 GDF2 Hsap 600ced8500002343 BMP9 signaling pathway (Human) NCBITaxon:9606 gomodel:600ced8500002343/600ced8500002344 GO:0008083 growth factor activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:P37023 ACVRL1 Hsap 600ced8500002343 BMP9 signaling pathway (Human) NCBITaxon:9606 gomodel:600ced8500002343/600ced8500002350 GO:0016361 activin receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q13705 ACVR2B Hsap 600ced8500002343 BMP9 signaling pathway (Human) NCBITaxon:9606 gomodel:600ced8500002343/600ced8500002422 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q13873 BMPR2 Hsap 600ced8500002343 BMP9 signaling pathway (Human) NCBITaxon:9606 gomodel:600ced8500002343/6446bfcb00001790 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 600ced8500002343 BMP9 signaling pathway (Human) NCBITaxon:9606 gomodel:600ced8500002343/6446bfcb00001798 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0000785 chromatin false UniProtKB:P56962 STX17 Hsap 6086f4f200000298 SARS-CoV-2/autophagy NCBITaxon:9606 gomodel:6086f4f200000298/60897d8500000001 GO:0005484 SNAP receptor activity GO:0061909 autophagosome-lysosome fusion GO:0000421 autophagosome membrane false UniProtKB:Q96JC1 VPS39 Hsap 6086f4f200000298 SARS-CoV-2/autophagy NCBITaxon:9606 gomodel:6086f4f200000298/60897d8500000034 GO:0060090 molecular adaptor activity GO:0061909 autophagosome-lysosome fusion GO:0005770 late endosome false UniProtKB:P0DTC3 ORF3a Scov2 6086f4f200000298 SARS-CoV-2/autophagy NCBITaxon:9606 gomodel:6086f4f200000298/6994852c00001872 GO:0140311 protein sequestering activity GO:0005770 late endosome false UniProtKB:Q96LD4-1 TRIM47 Hsap 60ad85f700000612 TRIM47-activity-on-ILF3 NCBITaxon:9606 gomodel:60ad85f700000612/617b481400002639 GO:0061630 ubiquitin protein ligase activity false UniProtKB:Q12906 ILF3 Hsap 60ad85f700000612 TRIM47-activity-on-ILF3 NCBITaxon:9606 gomodel:60ad85f700000612/617b481400002641 GO:0001618 virus receptor activity false UniProtKB:P19525 EIF2AK2 Hsap 60ad85f700000612 TRIM47-activity-on-ILF3 NCBITaxon:9606 gomodel:60ad85f700000612/617b481400002643 GO:0016301 kinase activity GO:0005737 cytoplasm false UniProtKB:Q8TDQ0 HAVCR2 Hsap 60ad85f700000612 TRIM47-activity-on-ILF3 NCBITaxon:9606 gomodel:60ad85f700000612/617b481400002646 GO:0005515 protein binding false UniProtKB:P04150 NR3C1 Hsap 60ad85f700001013 Transcription Factor - Target Gene NR3C1 KCNAB2 NCBITaxon:9606 gomodel:60ad85f700001013/60ad85f700001023 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false CHEBI:36080 protein 60ad85f700001013 Transcription Factor - Target Gene NR3C1 KCNAB2 NCBITaxon:9606 gomodel:60ad85f700001013/60d5209a00000199 GO:0004402 histone acetyltransferase activity GO:0006338 chromatin remodeling GO:0000785 chromatin false UniProtKB:Q13303 KCNAB2 Hsap 60ad85f700001013 Transcription Factor - Target Gene NR3C1 KCNAB2 NCBITaxon:9606 gomodel:60ad85f700001013/69ea894900001521 GO:0003674 molecular_function GO:0051384 response to glucocorticoid GO:0005575 cellular_component false UniProtKB:P04150 NR3C1 Hsap 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/60ad85f700002633 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false CHEBI:36080 protein 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/60ad85f700002648 GO:0044017 histone H3K27 acetyltransferase activity GO:0006338 chromatin remodeling GO:0000785 chromatin false UniProtKB:P07332 FES Hsap 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/69ea894900001532 GO:0003674 molecular_function GO:0051384 response to glucocorticoid GO:0005575 cellular_component false UniProtKB:P49641 MAN2A2 Hsap 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/69ea894900001541 GO:0003674 molecular_function GO:0051384 response to glucocorticoid GO:0005575 cellular_component false UniProtKB:P09958 FURIN Hsap 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/69ea894900001550 GO:0003674 molecular_function GO:0051384 response to glucocorticoid GO:0005575 cellular_component false UniProtKB:P54132 BLM Hsap 60ad85f700002621 Transcription Factor - Target Gene NR3C1 BLM FES HDDC3 MAN2A2 NCBITaxon:9606 gomodel:60ad85f700002621/69ea894900001556 GO:0003674 molecular_function GO:0051384 response to glucocorticoid GO:0005575 cellular_component false UniProtKB:P21980 TGM2 Hsap 613aae0000000338 TGM2 dopaminyltransferase activity towards Histone H3 (Human) NCBITaxon:9606 gomodel:613aae0000000338/613aae0000000340 GO:0120295 histone serotonyltransferase activity GO:0000785 chromatin false UniProtKB:P21980 TGM2 Hsap 613aae0000000338 TGM2 dopaminyltransferase activity towards Histone H3 (Human) NCBITaxon:9606 gomodel:613aae0000000338/613aae0000000424 GO:0120297 histone dopaminyltransferase activity GO:0000785 chromatin false UniProtKB:P68431 H3C1 Hsap 613aae0000000338 TGM2 dopaminyltransferase activity towards Histone H3 (Human) NCBITaxon:9606 gomodel:613aae0000000338/613aae0000000444 GO:0005515 protein binding GO:0000785 chromatin false UniProtKB:O00629 KPNA4 Hsap 613aae0000000338 TGM2 dopaminyltransferase activity towards Histone H3 (Human) NCBITaxon:9606 gomodel:613aae0000000338/613aae0000000490 GO:0061608 nuclear import signal receptor activity false UniProtKB:P55212 CASP6 Hsap 613aae0000000813 Liver apoptosis regulation by CASP6 (Human) NCBITaxon:9606 gomodel:613aae0000000813/613aae0000000814 GO:0004197 cysteine-type endopeptidase activity GO:0097284 hepatocyte apoptotic process false UniProtKB:P55957-4 BID Hsap 613aae0000000813 Liver apoptosis regulation by CASP6 (Human) NCBITaxon:9606 gomodel:613aae0000000813/613aae0000000821 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process GO:0090200 positive regulation of release of cytochrome c from mitochondria false UniProtKB:Q13131-2 PRKAA1 Hsap 613aae0000000813 Liver apoptosis regulation by CASP6 (Human) NCBITaxon:9606 gomodel:613aae0000000813/613aae0000000826 GO:0004674 protein serine/threonine kinase activity GO:1903944 negative regulation of hepatocyte apoptotic process false UniProtKB:P54646 PRKAA2 Hsap 613aae0000000813 Liver apoptosis regulation by CASP6 (Human) NCBITaxon:9606 gomodel:613aae0000000813/613aae0000000833 GO:0004674 protein serine/threonine kinase activity GO:1903944 negative regulation of hepatocyte apoptotic process false UniProtKB:P28827 PTPRM Hsap 613aae0000000885 PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) NCBITaxon:9606 gomodel:613aae0000000885/613aae0000000886 GO:0016791 phosphatase activity GO:0010828 positive regulation of D-glucose transmembrane transport GO:0005911 cell-cell junction false UniProtKB:O60716 CTNND1 Hsap 613aae0000000885 PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) NCBITaxon:9606 gomodel:613aae0000000885/613aae0000000901 GO:0140311 protein sequestering activity GO:0010829 negative regulation of D-glucose transmembrane transport GO:0005737 cytoplasm false UniProtKB:P14672 SLC2A4 Hsap 613aae0000000885 PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) NCBITaxon:9606 gomodel:613aae0000000885/613aae0000000906 GO:0055056 D-glucose transmembrane transporter activity GO:1904659 D-glucose transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q9NXF8 ZDHHC7 Hsap 613aae0000000885 PTPRM role in glucose transport activity through inhibition of CTNND1 (Human) NCBITaxon:9606 gomodel:613aae0000000885/614fa6f900001280 GO:0016409 palmitoyltransferase activity GO:0010828 positive regulation of D-glucose transmembrane transport false UniProtKB:O94762 RECQL5 Hsap 613aae0000001005 Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) NCBITaxon:9606 gomodel:613aae0000001005/613aae0000001006 GO:0004386 helicase activity GO:1990506 mitotic DNA-templated DNA replication GO:0005657 replication fork false UniProtKB:Q06609 RAD51 Hsap 613aae0000001005 Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) NCBITaxon:9606 gomodel:613aae0000001005/613aae0000001018 GO:0003697 single-stranded DNA binding GO:0099182 presynaptic intermediate filament cytoskeleton false UniProtKB:P06493 CDK1 Hsap 613aae0000001005 Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) NCBITaxon:9606 gomodel:613aae0000001005/613aae0000001024 GO:0016301 kinase activity false UniProtKB:Q96NY9 MUS81 Hsap 613aae0000001005 Activation of RECQL5 by CDK1 leading to mitotic DNA replication activation (Human) NCBITaxon:9606 gomodel:613aae0000001005/613aae0000001032 GO:0004519 endonuclease activity GO:0005657 replication fork false UniProtKB:Q9H6E5 TUT1 Hsap 614fa6f900000500 Regulation of RNA metabolism by SART3-mediated deubiquitination of TUT1 by USP15 (Human) NCBITaxon:9606 gomodel:614fa6f900000500/614fa6f900000501 GO:0050265 RNA uridylyltransferase activity GO:0051252 regulation of RNA metabolic process GO:0005654 nucleoplasm false UniProtKB:Q9Y4E8 USP15 Hsap 614fa6f900000500 Regulation of RNA metabolism by SART3-mediated deubiquitination of TUT1 by USP15 (Human) NCBITaxon:9606 gomodel:614fa6f900000500/614fa6f900000506 GO:0101005 deubiquitinase activity GO:0051252 regulation of RNA metabolic process GO:0005634 nucleus false UniProtKB:Q15020 SART3 Hsap 614fa6f900000500 Regulation of RNA metabolism by SART3-mediated deubiquitination of TUT1 by USP15 (Human) NCBITaxon:9606 gomodel:614fa6f900000500/61e0e55600000363 GO:0030674 protein-macromolecule adaptor activity GO:0051252 regulation of RNA metabolic process GO:0005634 nucleus false UniProtKB:Q9BY78 RNF26 Hsap 6168d1e000000007 SP_RNF26ubiquinatesSQSTM1 NCBITaxon:9606 gomodel:6168d1e000000007/6168d1e000000009 GO:0061630 ubiquitin protein ligase activity GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9Y385 UBE2J1 Hsap 6168d1e000000007 SP_RNF26ubiquinatesSQSTM1 NCBITaxon:9606 gomodel:6168d1e000000007/6168d1e000000017 GO:0005515 protein binding GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9H0E2 TOLLIP Hsap 6168d1e000000007 SP_RNF26ubiquinatesSQSTM1 NCBITaxon:9606 gomodel:6168d1e000000007/6168d1e000000025 GO:0060090 molecular adaptor activity false UniProtKB:Q92993 KAT5 Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000400 GO:0061733 protein-lysine-acetyltransferase activity GO:0062033 positive regulation of mitotic sister chromatid segregation GO:0000776 kinetochore false UniProtKB:Q96GD4 AURKB Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000409 GO:0004674 protein serine/threonine kinase activity GO:0062033 positive regulation of mitotic sister chromatid segregation false UniProtKB:Q92993 KAT5 Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000421 GO:0061733 protein-lysine-acetyltransferase activity GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore false UniProtKB:Q96GD4 AURKB Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000428 GO:0004674 protein serine/threonine kinase activity GO:0062033 positive regulation of mitotic sister chromatid segregation false UniProtKB:O14777 NDC80 Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000435 GO:0140483 kinetochore adaptor activity GO:0051315 attachment of mitotic spindle microtubules to kinetochore false UniProtKB:Q96EB6-2 SIRT1 Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000440 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:1902424 negative regulation of attachment of mitotic spindle microtubules to kinetochore false UniProtKB:P06493 CDK1 Hsap 617b481400000389 KAT5 regulation of the cytoskeleton by acetylation of proteins (Human) NCBITaxon:9606 gomodel:617b481400000389/617b481400000447 GO:0004674 protein serine/threonine kinase activity GO:0062033 positive regulation of mitotic sister chromatid segregation false UniProtKB:Q92993 KAT5 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000461 GO:0043998 histone H2A acetyltransferase activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q8IYW5 RNF168 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000468 GO:0140858 histone H2AK15 ubiquitin ligase activity GO:0006303 double-strand break repair via nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q12888 TP53BP1 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000475 GO:0140005 histone H4K20me2 reader activity GO:0006303 double-strand break repair via nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q05BQ5 MBTD1 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000482 GO:0140005 histone H4K20me2 reader activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9H2F5 EPC1 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000487 GO:0140463 chromatin-protein adaptor activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q12888 TP53BP1 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000511 GO:0061649 ubiquitin-modified histone reader activity GO:0006303 double-strand break repair via nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q05BQ5 MBTD1 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000753 GO:0062060 NuA4 histone acetyltransferase complex binding GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92993 KAT5 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000763 GO:0005515 protein binding GO:2000042 negative regulation of double-strand break repair via homologous recombination false UniProtKB:Q8N2W9 PIAS4 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000770 GO:0061665 SUMO ligase activity GO:1905168 positive regulation of double-strand break repair via homologous recombination false UniProtKB:Q9H4L4 SENP3 Hsap 617b481400000460 KAT5 involvement in DNA repair via homologous recombination (Human) NCBITaxon:9606 gomodel:617b481400000460/617b481400000777 GO:0008234 cysteine-type peptidase activity GO:2000042 negative regulation of double-strand break repair via homologous recombination false UniProtKB:Q92993 KAT5 Hsap 617b481400000521 KAT5 involvement in nucleotide excision repair (Human) NCBITaxon:9606 gomodel:617b481400000521/617b481400000522 GO:0061733 protein-lysine-acetyltransferase activity GO:0006289 nucleotide-excision repair false UniProtKB:Q96EB6 SIRT1 Hsap 617b481400000521 KAT5 involvement in nucleotide excision repair (Human) NCBITaxon:9606 gomodel:617b481400000521/617b481400000529 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0006289 nucleotide-excision repair false UniProtKB:Q92889-2 ERCC4 Hsap 617b481400000521 KAT5 involvement in nucleotide excision repair (Human) NCBITaxon:9606 gomodel:617b481400000521/617b481400000536 GO:0000014 single-stranded DNA endonuclease activity GO:0006289 nucleotide-excision repair false UniProtKB:Q92889-2 ERCC4 Hsap 617b481400000521 KAT5 involvement in nucleotide excision repair (Human) NCBITaxon:9606 gomodel:617b481400000521/617b481400000548 GO:0030674 protein-macromolecule adaptor activity GO:0006289 nucleotide-excision repair false UniProtKB:Q92993 KAT5 Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000560 GO:0061733 protein-lysine-acetyltransferase activity GO:0042149 cellular response to glucose starvation false UniProtKB:Q13131 PRKAA1 Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000567 GO:0004674 protein serine/threonine kinase activity GO:1990044 protein localization to lipid droplet false UniProtKB:P54646 PRKAA2 Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000574 GO:0004674 protein serine/threonine kinase activity GO:1990044 protein localization to lipid droplet false UniProtKB:P35790-1 CHKA Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000581 GO:0004713 protein tyrosine kinase activity GO:0005811 lipid droplet false UniProtKB:P35790-1 CHKA Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000592 GO:0004103 choline kinase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005829 cytosol false UniProtKB:P35790-1 CHKA Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000599 GO:0042803 protein homodimerization activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005829 cytosol false UniProtKB:P35790-1 CHKA Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000606 GO:0005515 protein binding GO:0042149 cellular response to glucose starvation GO:0005811 lipid droplet false UniProtKB:P35790-1 CHKA Hsap 617b481400000559 KAT5 regulation of lipid droplet disassembly (Human) NCBITaxon:9606 gomodel:617b481400000559/617b481400000615 GO:0004305 ethanolamine kinase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005829 cytosol false UniProtKB:P50750 CDK9 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000673 GO:0004674 protein serine/threonine kinase activity GO:0120187 positive regulation of protein localization to chromatin false UniProtKB:Q92993 KAT5 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000680 GO:0003682 chromatin binding GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q92993 KAT5 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000687 GO:0004402 histone acetyltransferase activity GO:0045944 positive regulation of transcription by RNA polymerase II false UniProtKB:Q99986 VRK1 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000692 GO:0004674 protein serine/threonine kinase activity GO:0120187 positive regulation of protein localization to chromatin false UniProtKB:Q92993 KAT5 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000699 GO:0046972 histone H4K16 acetyltransferase activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q92993 KAT5 Hsap 617b481400000672 KAT5 chromatin localization (Human) NCBITaxon:9606 gomodel:617b481400000672/617b481400000706 GO:0003682 chromatin binding GO:0006974 DNA damage response GO:0000785 chromatin false UniProtKB:Q92993 KAT5 Hsap 617b481400000793 KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 (Human) NCBITaxon:9606 gomodel:617b481400000793/617b481400000794 GO:0004402 histone acetyltransferase activity GO:0140861 DNA repair-dependent chromatin remodeling GO:0005634 nucleus false UniProtKB:Q92993 KAT5 Hsap 617b481400000793 KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 (Human) NCBITaxon:9606 gomodel:617b481400000793/617b481400000801 GO:0061733 protein-lysine-acetyltransferase activity GO:0140861 DNA repair-dependent chromatin remodeling GO:0005634 nucleus false UniProtKB:O15379 HDAC3 Hsap 617b481400000793 KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 (Human) NCBITaxon:9606 gomodel:617b481400000793/617b481400000810 GO:0033558 protein lysine deacetylase activity GO:0140861 DNA repair-dependent chromatin remodeling false UniProtKB:Q96EB6 SIRT1 Hsap 617b481400000793 KAT5 autoacetylation and deacetylation by HDAC3 and SIRT1 (Human) NCBITaxon:9606 gomodel:617b481400000793/617b481400000817 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0140861 DNA repair-dependent chromatin remodeling false UniProtKB:Q13627 DYRK1A Hsap 617b481400003575 Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) NCBITaxon:9606 gomodel:617b481400003575/617b481400003576 GO:0106310 protein serine kinase activity GO:2000781 positive regulation of double-strand break repair false UniProtKB:Q12888 TP53BP1 Hsap 617b481400003575 Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) NCBITaxon:9606 gomodel:617b481400003575/617b481400003582 GO:0061649 ubiquitin-modified histone reader activity GO:0006303 double-strand break repair via nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q8NCN4 RNF169 Hsap 617b481400003575 Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) NCBITaxon:9606 gomodel:617b481400003575/617b481400003584 GO:0061649 ubiquitin-modified histone reader activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q96RL1 UIMC1 Hsap 617b481400003575 Role of RNF169 in double-strand break repair upon DYRK1A activation (Human) NCBITaxon:9606 gomodel:617b481400003575/617b481400003589 GO:0061649 ubiquitin-modified histone reader activity GO:0006303 double-strand break repair via nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q86VK4 ZNF410 Hsap 6197061700001485 Silencing of fetal hemoglobin by ZNF410 (Human) NCBITaxon:9606 gomodel:6197061700001485/6197061700001486 GO:0003700 DNA-binding transcription factor activity GO:0045944 positive regulation of transcription by RNA polymerase II CL:0000764 erythroid lineage cell false UniProtKB:P69891 HBG1 Hsap 6197061700001485 Silencing of fetal hemoglobin by ZNF410 (Human) NCBITaxon:9606 gomodel:6197061700001485/6197061700001496 GO:0005344 oxygen carrier activity GO:0015671 oxygen transport CL:0000232 erythrocyte false UniProtKB:P69892 HBG2 Hsap 6197061700001485 Silencing of fetal hemoglobin by ZNF410 (Human) NCBITaxon:9606 gomodel:6197061700001485/6197061700001501 GO:0005344 oxygen carrier activity GO:0015671 oxygen transport CL:0000232 erythrocyte false UniProtKB:Q14839 CHD4 Hsap 6197061700001485 Silencing of fetal hemoglobin by ZNF410 (Human) NCBITaxon:9606 gomodel:6197061700001485/6197061700001506 GO:0003714 transcription corepressor activity GO:0010629 negative regulation of gene expression CL:0000764 erythroid lineage cell false UniProtKB:P07948 LYN Hsap 6197061700002397 Fatty acid transport by CD36 via LYN-mediated endocytosis (Human) NCBITaxon:9606 gomodel:6197061700002397/6197061700002403 GO:0004713 protein tyrosine kinase activity GO:0015908 fatty acid transport GO:0005886 plasma membrane false UniProtKB:Q9C0B5 ZDHHC5 Hsap 6197061700002397 Fatty acid transport by CD36 via LYN-mediated endocytosis (Human) NCBITaxon:9606 gomodel:6197061700002397/6197061700002406 GO:0016409 palmitoyltransferase activity GO:1903078 positive regulation of protein localization to plasma membrane GO:0005886 plasma membrane false UniProtKB:O75608 LYPLA1 Hsap 6197061700002397 Fatty acid transport by CD36 via LYN-mediated endocytosis (Human) NCBITaxon:9606 gomodel:6197061700002397/6197061700002409 GO:0008474 palmitoyl-(protein) hydrolase activity GO:0015908 fatty acid transport GO:0005886 plasma membrane false UniProtKB:P16671 CD36 Hsap 6197061700002397 Fatty acid transport by CD36 via LYN-mediated endocytosis (Human) NCBITaxon:9606 gomodel:6197061700002397/65d7e4ac00001265 GO:0038023 signaling receptor activity GO:0015908 fatty acid transport GO:0005886 plasma membrane false UniProtKB:P59044 NLRP6 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000001 GO:0038187 pattern recognition receptor activity GO:0140739 NLRP6 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P59044 NLRP6 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000010 GO:0140693 molecular condensate scaffold activity GO:0140739 NLRP6 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000027 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000050 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000057 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:P01584 IL1B Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000068 GO:0005125 cytokine activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q14116 IL18 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000078 GO:0005125 cytokine activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P59044 NLRP6 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61b2b68300000115 GO:0035591 signaling adaptor activity GO:0140739 NLRP6 inflammasome complex assembly false UniProtKB:P29466 CASP1 Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/61e0e55600002330 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 61b2b68300000000 Activation of the NLRP6 inflammasome in response to lipoteichoic acid (Human) NCBITaxon:9606 gomodel:61b2b68300000000/635b1e3e00001559 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:Q9H825 METTL8 Hsap 61bcf0b700000524 tRNA methylation by METTL8 and regulation by tRNA dimethylallyltransferase activity of TRIT1 (Human) NCBITaxon:9606 gomodel:61bcf0b700000524/61bcf0b700000525 GO:0052735 tRNA (cytidine-N3)-methyltransferase activity GO:0070900 mitochondrial tRNA modification GO:0005739 mitochondrion false UniProtKB:Q9H825 METTL8 Hsap 61bcf0b700000524 tRNA methylation by METTL8 and regulation by tRNA dimethylallyltransferase activity of TRIT1 (Human) NCBITaxon:9606 gomodel:61bcf0b700000524/61bcf0b700000534 GO:0052735 tRNA (cytidine-N3)-methyltransferase activity GO:0070900 mitochondrial tRNA modification GO:0005739 mitochondrion false UniProtKB:Q9H3H1 TRIT1 Hsap 61bcf0b700000524 tRNA methylation by METTL8 and regulation by tRNA dimethylallyltransferase activity of TRIT1 (Human) NCBITaxon:9606 gomodel:61bcf0b700000524/61bcf0b700000543 GO:0052381 tRNA dimethylallyltransferase activity GO:0070900 mitochondrial tRNA modification GO:0005739 mitochondrion false UniProtKB:Q9NXI6 RNF186 Hsap 61e0e55600000338 SP_RNF186onEPHRINs NCBITaxon:9606 gomodel:61e0e55600000338/61e0e55600000339 GO:0061630 ubiquitin protein ligase activity false UniProtKB:P98172 EFNB1 Hsap 61e0e55600000338 SP_RNF186onEPHRINs NCBITaxon:9606 gomodel:61e0e55600000338/61e0e55600000345 GO:0046875 ephrin receptor binding GO:0009986 cell surface false UniProtKB:P29323 EPHB2 Hsap 61e0e55600000338 SP_RNF186onEPHRINs NCBITaxon:9606 gomodel:61e0e55600000338/61e0e55600000351 GO:0005515 protein binding false UniProtKB:P62136 PPP1CA Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000408 GO:0016791 phosphatase activity GO:0005783 endoplasmic reticulum false UniProtKB:P05198 EIF2S1 Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000412 GO:0160296 cap-dependent translation initiation factor activity GO:0005737 cytoplasm false UniProtKB:O75807 PPP1R15A Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000459 GO:0060090 molecular adaptor activity GO:0005783 endoplasmic reticulum false UniProtKB:P19525 EIF2AK2 Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000588 GO:0004674 protein serine/threonine kinase activity false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000595 GO:0004672 protein kinase activity GO:0034976 response to endoplasmic reticulum stress GO:0005783 endoplasmic reticulum false UniProtKB:Q9P2K8 EIF2AK4 Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000604 GO:0004672 protein kinase activity GO:1990928 response to amino acid starvation false UniProtKB:Q5SWA1 PPP1R15B Hsap 61e0e55600000407 SP_GADD34- PPP1CA NCBITaxon:9606 gomodel:61e0e55600000407/61e0e55600000613 GO:0060090 molecular adaptor activity false UniProtKB:Q9C0C7 AMBRA1 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000626 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P24385 CCND1 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000658 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:P11802 CDK4 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000667 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:P30279 CCND2 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000678 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:Q9C0C7 AMBRA1 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000685 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9C0C7 AMBRA1 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000695 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P30281 CCND3 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000705 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:Q00534 CDK6 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/61e0e55600000712 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:P24385 CCND1 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/62183af000000898 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:P30279 CCND2 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/62183af000000905 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:P30281 CCND3 Hsap 61e0e55600000624 Cyclin-D ubiquitination and degradation by AMBRA1 (Human) NCBITaxon:9606 gomodel:61e0e55600000624/62183af000000912 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle false UniProtKB:Q9C000 NLRP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001298 GO:0003725 double-stranded RNA binding GO:0051607 defense response to virus GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001307 GO:0038187 pattern recognition receptor activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001314 GO:0140693 molecular condensate scaffold activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001324 GO:0035591 signaling adaptor activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001333 GO:0140608 cysteine-type endopeptidase activator activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001342 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001351 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001360 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:Q6V1X1 DPP8 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001367 GO:0008239 dipeptidyl-peptidase activity GO:0043069 negative regulation of programmed cell death GO:0005737 cytoplasm false UniProtKB:Q86TI2 DPP9 Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/61e0e55600001376 GO:0008239 dipeptidyl-peptidase activity GO:0043069 negative regulation of programmed cell death GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 61e0e55600001295 NLRP1 inflammasome leading to pyroptosis (Human) NCBITaxon:9606 gomodel:61e0e55600001295/635b1e3e00001550 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P10144 GZMB Hsap 61e0e55600001659 Granzyme-mediated (GZMB) activation of pyroptosis (GSDME) (Human) NCBITaxon:9606 gomodel:61e0e55600001659/61e0e55600001680 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:O60443-PRO_0000442786 GSDME-GSDME-NT Hsap 61e0e55600001659 Granzyme-mediated (GZMB) activation of pyroptosis (GSDME) (Human) NCBITaxon:9606 gomodel:61e0e55600001659/61e0e55600001689 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death false UniProtKB:P14222 PRF1 Hsap 61e0e55600001659 Granzyme-mediated (GZMB) activation of pyroptosis (GSDME) (Human) NCBITaxon:9606 gomodel:61e0e55600001659/61e0e55600001695 GO:0022829 wide pore channel activity GO:0071806 protein transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q92982 NINJ1 Hsap 61e0e55600001659 Granzyme-mediated (GZMB) activation of pyroptosis (GSDME) (Human) NCBITaxon:9606 gomodel:61e0e55600001659/663d668500001234 GO:0140912 membrane destabilizing activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:Q53H80 AKIRIN2 Hsap 61f34dd300000000 Nuclear import of the proteasome by AKIRIN2 (Human) NCBITaxon:9606 gomodel:61f34dd300000000/61f34dd300000001 GO:0030674 protein-macromolecule adaptor activity GO:0031144 proteasome localization GO:0005634 nucleus false UniProtKB:Q96P70 IPO9 Hsap 61f34dd300000000 Nuclear import of the proteasome by AKIRIN2 (Human) NCBITaxon:9606 gomodel:61f34dd300000000/61f34dd300000012 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus false GO:0005839 proteasome core complex 61f34dd300000000 Nuclear import of the proteasome by AKIRIN2 (Human) NCBITaxon:9606 gomodel:61f34dd300000000/61f34dd300000026 GO:0004175 endopeptidase activity GO:0010498 proteasomal protein catabolic process GO:0005634 nucleus false UniProtKB:Q5VWK5 IL23R Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/6205c24300002130 GO:0004896 cytokine receptor activity GO:0038155 interleukin-23-mediated signaling pathway GO:0009986 cell surface false UniProtKB:P42701 IL12RB1 Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/6205c24300002145 GO:0015026 coreceptor activity GO:0038155 interleukin-23-mediated signaling pathway false UniProtKB:O60674 JAK2 Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/62183af000000016 GO:0004713 protein tyrosine kinase activity GO:0038155 interleukin-23-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/62183af000000030 GO:0003700 DNA-binding transcription factor activity GO:0038155 interleukin-23-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P29597 TYK2 Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/62183af000000039 GO:0004713 protein tyrosine kinase activity GO:0038155 interleukin-23-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q14765 STAT4 Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/62183af000000046 GO:0003700 DNA-binding transcription factor activity false ComplexPortal:CPX-3290 interleukin-23_human Hsap 61f34dd300000787 IL23 signaling pathway (Human) NCBITaxon:9606 gomodel:61f34dd300000787/665912ed00000000 GO:0005125 cytokine activity GO:0038155 interleukin-23-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P14618-1 PKM Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000864 GO:0004743 pyruvate kinase activity GO:0006096 glycolytic process GO:0005737 cytoplasm false UniProtKB:P14618-1 PKM Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000872 GO:0035402 histone H3T11 kinase activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P14618-1 PKM Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000879 GO:0004713 protein tyrosine kinase activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q09472 EP300 Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000892 GO:0061733 protein-lysine-acetyltransferase activity GO:0042307 positive regulation of protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q8N6T7 SIRT6 Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000904 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0046827 positive regulation of protein export from nucleus GO:0005634 nucleus false UniProtKB:Q9C0E2 XPO4 Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000915 GO:0005049 nuclear export signal receptor activity GO:0006611 protein export from nucleus GO:0005634 nucleus false UniProtKB:P62826 RAN Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000936 GO:0003925 G protein activity GO:0006611 protein export from nucleus GO:0005634 nucleus false UniProtKB:Q9C0E2 XPO4 Hsap 61f34dd300000863 PKM2 acetylation by EP300 and deacetylation by SIRT6 leading to conversion into a protein kinase (Human) NCBITaxon:9606 gomodel:61f34dd300000863/61f34dd300000962 GO:0031267 small GTPase binding GO:0006611 protein export from nucleus GO:0005634 nucleus false UniProtKB:Q8N6T7 SIRT6 Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300000982 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0045721 negative regulation of gluconeogenesis GO:0005634 nucleus false UniProtKB:Q8N6T7 SIRT6 Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300000991 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0046827 positive regulation of protein export from nucleus GO:0005634 nucleus false UniProtKB:Q92830 KAT2A Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300001002 GO:0061733 protein-lysine-acetyltransferase activity GO:0045721 negative regulation of gluconeogenesis GO:0005634 nucleus false UniProtKB:Q9UBK2 PPARGC1A Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300001014 GO:0003713 transcription coactivator activity GO:0006094 gluconeogenesis GO:0005634 nucleus false UniProtKB:Q96EB6 SIRT1 Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300001021 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0045722 positive regulation of gluconeogenesis GO:0005634 nucleus false UniProtKB:Q12778 FOXO1 Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300001030 GO:0003700 DNA-binding transcription factor activity GO:0045722 positive regulation of gluconeogenesis GO:0005634 nucleus false UniProtKB:Q96EB6 SIRT1 Hsap 61f34dd300000981 Regulation of gluconeogenesis by SIRT6, FOXO1 and KAT2A/GCN5 (Human) NCBITaxon:9606 gomodel:61f34dd300000981/61f34dd300001081 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0051658 maintenance of nucleus location GO:0005634 nucleus false RNAcentral:URS0000BC450A_9606 URS0000BC450A_9606 Hsap 6205c24300000050 SIRT6 inactivation by lncPRESS1 RNA (Human) NCBITaxon:9606 gomodel:6205c24300000050/6205c24300000051 GO:0005515 protein binding GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:Q8N6T7 SIRT6 Hsap 6205c24300000050 SIRT6 inactivation by lncPRESS1 RNA (Human) NCBITaxon:9606 gomodel:6205c24300000050/6205c24300000058 GO:0003682 chromatin binding GO:2000738 positive regulation of stem cell differentiation GO:0000785 chromatin false UniProtKB:Q8N6T7 SIRT6 Hsap 6205c24300000050 SIRT6 inactivation by lncPRESS1 RNA (Human) NCBITaxon:9606 gomodel:6205c24300000050/6205c24300000065 GO:0017136 histone deacetylase activity, NAD-dependent GO:2000738 positive regulation of stem cell differentiation GO:0000785 chromatin false UniProtKB:Q8N6T7 SIRT6 Hsap 6205c24300000050 SIRT6 inactivation by lncPRESS1 RNA (Human) NCBITaxon:9606 gomodel:6205c24300000050/6205c24300000072 GO:0106222 lncRNA binding GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:O95922 TTLL1 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300000331 GO:0070740 tubulin-glutamic acid ligase activity GO:0000226 microtubule cytoskeleton organization GO:0005874 microtubule false UniProtKB:P27816 MAP4 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300000347 GO:0140778 microtubule stabilizing activity GO:0046785 microtubule polymerization GO:0005874 microtubule false UniProtKB:P06493 CDK1 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300000354 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:1902850 microtubule cytoskeleton organization involved in mitosis false UniProtKB:Q15154 PCM1 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300000453 GO:0030674 protein-macromolecule adaptor activity GO:0140706 protein-containing complex localization to centriolar satellite GO:0034451 centriolar satellite false UniProtKB:Q96L34 MARK4 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300001410 GO:0004674 protein serine/threonine kinase activity GO:0000226 microtubule cytoskeleton organization GO:0005874 microtubule false UniProtKB:Q9H6J7 CSTPP1 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300001427 GO:0030674 protein-macromolecule adaptor activity GO:0061635 regulation of protein complex stability GO:0034451 centriolar satellite false UniProtKB:Q6ZTW0 TPGS1 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300001444 GO:0030674 protein-macromolecule adaptor activity GO:0000226 microtubule cytoskeleton organization GO:0005874 microtubule false UniProtKB:Q68CL5 TPGS2 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300001454 GO:0030674 protein-macromolecule adaptor activity GO:0000226 microtubule cytoskeleton organization GO:0005874 microtubule false UniProtKB:Q8IUZ0-4 LRRC49 Hsap 6205c24300000330 Microtubule polyglutamylation regulation (Human) NCBITaxon:9606 gomodel:6205c24300000330/6205c24300001464 GO:0030674 protein-macromolecule adaptor activity GO:0000226 microtubule cytoskeleton organization GO:0005874 microtubule false UniProtKB:P35558 PCK1 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000815 GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity GO:0006094 gluconeogenesis GO:0005829 cytosol false UniProtKB:P35558 PCK1 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000826 GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity GO:0072350 tricarboxylic acid metabolic process GO:0005829 cytosol false UniProtKB:Q09472 EP300 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000835 GO:0061733 protein-lysine-acetyltransferase activity GO:0045721 negative regulation of gluconeogenesis GO:0005829 cytosol false UniProtKB:Q96EB6 SIRT1 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000844 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0045722 positive regulation of gluconeogenesis GO:0005829 cytosol false UniProtKB:P35558 PCK1 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000857 GO:0106264 protein serine kinase activity (using GTP as donor) GO:0046889 positive regulation of lipid biosynthetic process GO:0005783 endoplasmic reticulum false UniProtKB:P31749 AKT1 Hsap 6205c24300000814 PCK1 phosphoenolpyruvate carboxykinase and protein kinase activites and their regulation by acetylation (EP300), deacetylation (SIRT1) and phosphorylation (AKT1) (Human) NCBITaxon:9606 gomodel:6205c24300000814/6205c24300000868 GO:0004674 protein serine/threonine kinase activity GO:1905552 positive regulation of protein localization to endoplasmic reticulum GO:0005829 cytosol false UniProtKB:P35558 PCK1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000881 GO:0106264 protein serine kinase activity (using GTP as donor) GO:0046889 positive regulation of lipid biosynthetic process GO:0005783 endoplasmic reticulum false UniProtKB:P31749 AKT1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000892 GO:0004674 protein serine/threonine kinase activity GO:1905552 positive regulation of protein localization to endoplasmic reticulum GO:0005829 cytosol false UniProtKB:O15503 INSIG1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000901 GO:0008142 oxysterol binding GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9Y5U4 INSIG2 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000909 GO:0008142 oxysterol binding GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:O15503 INSIG1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000917 GO:0140311 protein sequestering activity GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9Y5U4 INSIG2 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000929 GO:0140311 protein sequestering activity GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:P36956 SREBF1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000989 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005634 nucleus false UniProtKB:Q12772 SREBF2 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300000999 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005634 nucleus false UniProtKB:Q14703 MBTPS1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001010 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:O43462 MBTPS2 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001020 GO:0004222 metalloendopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:Q14974 KPNB1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001031 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q14974 KPNB1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001135 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:O43462 MBTPS2 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001240 GO:0004222 metalloendopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:Q14703 MBTPS1 Hsap 6205c24300000880 Regulation of cholesterol biosynthesis by SREBP (SREBF1 and SREBF2) and retention by the SREBP-SCAP complex (Human) NCBITaxon:9606 gomodel:6205c24300000880/6205c24300001290 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:P60568 IL2 Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6205c24300001664 GO:0005125 cytokine activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P14784 IL2RB Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6205c24300001733 GO:0015026 coreceptor activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6205c24300001744 GO:0004713 protein tyrosine kinase activity GO:0038110 interleukin-2-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P52333 JAK3 Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6205c24300001751 GO:0004713 protein tyrosine kinase activity GO:0038110 interleukin-2-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P42229 STAT5A Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6205c24300001760 GO:0003700 DNA-binding transcription factor activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P31785 IL2RG Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6246724f00000700 GO:0015026 coreceptor activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P01589 IL2RA Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/6246724f00000990 GO:0004911 interleukin-2 receptor activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P40763 STAT3 Hsap 6205c24300001663 IL2 signaling pathway (Human) NCBITaxon:9606 gomodel:6205c24300001663/627d95ee00000553 GO:0003700 DNA-binding transcription factor activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005634 nucleus false UniProtKB:Q8N6T7 SIRT6 Hsap 62183af000000536 DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) NCBITaxon:9606 gomodel:62183af000000536/62183af000000537 GO:0003684 damaged DNA binding GO:2000781 positive regulation of double-strand break repair GO:0035861 site of double-strand break false UniProtKB:Q8N6T7 SIRT6 Hsap 62183af000000536 DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) NCBITaxon:9606 gomodel:62183af000000536/62183af000000547 GO:0140612 DNA damage sensor activity GO:2000781 positive regulation of double-strand break repair GO:0035861 site of double-strand break false UniProtKB:Q8N6T7 SIRT6 Hsap 62183af000000536 DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) NCBITaxon:9606 gomodel:62183af000000536/62183af000000557 GO:0140765 histone H3K56 deacetylase activity, NAD-dependent GO:2000781 positive regulation of double-strand break repair GO:0035861 site of double-strand break false UniProtKB:Q96EB6 SIRT1 Hsap 62183af000000536 DNA damage sensor activity of SIRT6 and its regulation by SIRT1 (Human) NCBITaxon:9606 gomodel:62183af000000536/62183af000000578 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:2000781 positive regulation of double-strand break repair false UniProtKB:Q8WWH5 TRUB1 Hsap 62183af000000874 miRNA maturation by TRUB1 (Human) NCBITaxon:9606 gomodel:62183af000000874/62183af000000875 GO:0070883 pre-miRNA binding GO:2000633 positive regulation of pre-miRNA processing false UniProtKB:Q9H9Z2 LIN28A Hsap 62183af000000874 miRNA maturation by TRUB1 (Human) NCBITaxon:9606 gomodel:62183af000000874/62183af000000882 GO:0070883 pre-miRNA binding GO:2000632 negative regulation of pre-miRNA processing false UniProtKB:Q8WYQ5 DGCR8 Hsap 62183af000000874 miRNA maturation by TRUB1 (Human) NCBITaxon:9606 gomodel:62183af000000874/62183af000000889 GO:0140517 protein-RNA adaptor activity GO:2000633 positive regulation of pre-miRNA processing false UniProtKB:Q8N6T7 SIRT6 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000523 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q8N6T7 SIRT6 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000535 GO:0140612 DNA damage sensor activity GO:2000781 positive regulation of double-strand break repair GO:0035861 site of double-strand break false UniProtKB:P09874 PARP1 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000542 GO:0003684 damaged DNA binding GO:0006302 double-strand break repair GO:0035861 site of double-strand break false UniProtKB:P09874 PARP1 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000558 GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity GO:0006302 double-strand break repair GO:0035861 site of double-strand break false UniProtKB:P09874 PARP1 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000567 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0070212 protein poly-ADP-ribosylation GO:0035861 site of double-strand break false UniProtKB:Q9NWY4 HPF1 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000574 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:0006302 double-strand break repair GO:0090734 site of DNA damage false UniProtKB:P45983 MAPK8 Hsap 622aace900000522 ADP-ribosyltransferase activity of SIRT6 and ADP-ribosylation of PARP1 during DNA repair (Human) NCBITaxon:9606 gomodel:622aace900000522/622aace900000585 GO:0004674 protein serine/threonine kinase activity GO:0034599 cellular response to oxidative stress false UniProtKB:P11169 SLC2A3 Hsap 622aace900001143 SLC2A3 glucose transporter activity. (Human) NCBITaxon:9606 gomodel:622aace900001143/622aace900001144 GO:0055056 D-glucose transmembrane transporter activity GO:0005886 plasma membrane false UniProtKB:P05112 IL4 Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000292 GO:0005125 cytokine activity GO:0035771 interleukin-4-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P24394 IL4R Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000299 GO:0004913 interleukin-4 receptor activity GO:0035771 interleukin-4-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000305 GO:0004713 protein tyrosine kinase activity GO:0035771 interleukin-4-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P52333 JAK3 Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000309 GO:0004713 protein tyrosine kinase activity GO:0035771 interleukin-4-mediated signaling pathway GO:0019897 extrinsic component of plasma membrane false UniProtKB:P31785 IL2RG Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000313 GO:0015026 coreceptor activity GO:0035771 interleukin-4-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42226 STAT6 Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/623d156d00000325 GO:0003700 DNA-binding transcription factor activity GO:0035771 interleukin-4-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P42229 STAT5A Hsap 623d156d00000290 IL4-mediated signaling pathway (human) NCBITaxon:9606 gomodel:623d156d00000290/626b20c100000122 GO:0003700 DNA-binding transcription factor activity GO:0035771 interleukin-4-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P08700 IL3 Hsap 623d156d00000340 IL3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000340/623d156d00000342 GO:0005125 cytokine activity GO:0038156 interleukin-3-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P26951 IL3RA Hsap 623d156d00000340 IL3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000340/623d156d00000346 GO:0004912 interleukin-3 receptor activity GO:0038156 interleukin-3-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P32927 CSF2RB Hsap 623d156d00000340 IL3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000340/623d156d00000352 GO:0015026 coreceptor activity GO:0038156 interleukin-3-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 623d156d00000340 IL3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000340/623d156d00000369 GO:0004713 protein tyrosine kinase activity GO:0038156 interleukin-3-mediated signaling pathway GO:0019897 extrinsic component of plasma membrane false UniProtKB:P42229 STAT5A Hsap 623d156d00000340 IL3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000340/623d156d00000374 GO:0003700 DNA-binding transcription factor activity GO:0038156 interleukin-3-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P05113 IL5 Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/623d156d00000675 GO:0005125 cytokine activity GO:0038043 interleukin-5-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q01344 IL5RA Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/623d156d00000679 GO:0004914 interleukin-5 receptor activity GO:0038043 interleukin-5-mediated signaling pathway CL:0000771 eosinophil false UniProtKB:P32927 CSF2RB Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/623d156d00000696 GO:0015026 coreceptor activity GO:0038043 interleukin-5-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/6246724f00000597 GO:0004713 protein tyrosine kinase activity GO:0038043 interleukin-5-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P42229 STAT5A Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/6246724f00000601 GO:0003700 DNA-binding transcription factor activity GO:0038043 interleukin-5-mediated signaling pathway CL:0000771 eosinophil false UniProtKB:P07948 LYN Hsap 623d156d00000673 IL5-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:623d156d00000673/6246724f00000610 GO:0004713 protein tyrosine kinase activity GO:0038043 interleukin-5-mediated signaling pathway CL:0000771 eosinophil false UniProtKB:P78527 PRKDC Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000818 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response GO:0000785 chromatin false UniProtKB:Q9Y294 ASF1A Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000827 GO:0140713 histone chaperone activity GO:0140861 DNA repair-dependent chromatin remodeling GO:0035861 site of double-strand break false UniProtKB:Q96HA7 TONSL Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000836 GO:0140566 histone reader activity GO:0071168 protein localization to chromatin GO:0035861 site of double-strand break false UniProtKB:Q6ZRQ5 MMS22L Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000850 GO:0003697 single-stranded DNA binding GO:0071168 protein localization to chromatin GO:0035861 site of double-strand break false UniProtKB:Q06609 RAD51 Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000870 GO:0000150 DNA strand exchange activity GO:0031297 replication fork processing GO:0035861 site of double-strand break false UniProtKB:Q9NQR1 KMT5A Hsap 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000879 GO:0042799 histone H4K20 methyltransferase activity GO:2000042 negative regulation of double-strand break repair via homologous recombination GO:0000785 chromatin false GO:0005662 DNA replication factor A complex 623d156d00000817 Role of TONSL and MMS22L (TONSL-MMS22L complex) in promoting homologous recombination-mediated repair of DSBs (Human) NCBITaxon:9606 gomodel:623d156d00000817/623d156d00000886 GO:0003682 chromatin binding GO:0006281 DNA repair GO:0000228 nuclear chromosome false UniProtKB:P58004 SESN2 Hsap 6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) NCBITaxon:9606 gomodel:6246724f00000283/6246724f00000295 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling GO:0005737 cytoplasm false UniProtKB:Q9H6Y7 RNF167 Hsap 6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) NCBITaxon:9606 gomodel:6246724f00000283/6246724f00000306 GO:0004842 ubiquitin-protein transferase activity GO:0070534 protein K63-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:Q96FJ0 STAMBPL1 Hsap 6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) NCBITaxon:9606 gomodel:6246724f00000283/6246724f00000319 GO:0061578 K63-linked deubiquitinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P58004 SESN2 Hsap 6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) NCBITaxon:9606 gomodel:6246724f00000283/6482692800001952 GO:0070728 L-leucine binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q96S15 WDR24 Hsap 6246724f00000283 Regulation of the mTORC1 signaling via ubiquitination and deubiquitnation of SESN2 by RNF167 and STAMBPL1 (Human) NCBITaxon:9606 gomodel:6246724f00000283/6482692800001972 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:Q9H6Y7 RNF167 Hsap 6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human) NCBITaxon:9606 gomodel:6246724f00000369/6246724f00000370 GO:0004842 ubiquitin-protein transferase activity GO:0035519 protein K29-linked ubiquitination false UniProtKB:Q8WTX7 CASTOR1 Hsap 6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human) NCBITaxon:9606 gomodel:6246724f00000369/6246724f00000381 GO:0034618 arginine binding GO:1904263 positive regulation of TORC1 signaling GO:0005829 cytosol false UniProtKB:Q8WTX7 CASTOR1 Hsap 6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human) NCBITaxon:9606 gomodel:6246724f00000369/6246724f00000390 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling GO:0005829 cytosol false UniProtKB:P31749 AKT1 Hsap 6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human) NCBITaxon:9606 gomodel:6246724f00000369/6246724f00000416 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q96S15 WDR24 Hsap 6246724f00000369 Regulation of the mTORC1 signaling via ubiquitination and degradation of CASTOR1 by RNF167 (Human) NCBITaxon:9606 gomodel:6246724f00000369/6482692800001988 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:P12821 ACE Hsap 6246724f00000549 Renin-angiotensin pathway (Human) NCBITaxon:9606 gomodel:6246724f00000549/6246724f00000550 GO:0008241 peptidyl-dipeptidase activity GO:0002003 angiotensin maturation GO:0005576 extracellular region false UniProtKB:P00797-1 REN Hsap 6246724f00000549 Renin-angiotensin pathway (Human) NCBITaxon:9606 gomodel:6246724f00000549/6246724f00000562 GO:0004190 aspartic-type endopeptidase activity GO:0002003 angiotensin maturation GO:0005576 extracellular region false UniProtKB:P01019 AGT Hsap 6246724f00000549 Renin-angiotensin pathway (Human) NCBITaxon:9606 gomodel:6246724f00000549/6246724f00000571 GO:0005179 hormone activity GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin GO:0005576 extracellular region false UniProtKB:P30556 AGTR1 Hsap 6246724f00000549 Renin-angiotensin pathway (Human) NCBITaxon:9606 gomodel:6246724f00000549/6246724f00000580 GO:0001596 angiotensin type I receptor activity GO:0038166 angiotensin-activated signaling pathway GO:0005886 plasma membrane false UniProtKB:P12821 ACE Hsap 6246724f00000632 Bradykinin degradation by ACE and bradykin-binding to its receptor (Human) NCBITaxon:9606 gomodel:6246724f00000632/6246724f00000633 GO:0008241 peptidyl-dipeptidase activity GO:0010815 bradykinin catabolic process GO:0005576 extracellular region false UniProtKB:P01042 KNG1 Hsap 6246724f00000632 Bradykinin degradation by ACE and bradykin-binding to its receptor (Human) NCBITaxon:9606 gomodel:6246724f00000632/6246724f00000645 GO:0005179 hormone activity GO:0042311 vasodilation GO:0005576 extracellular region false UniProtKB:P30411 BDKRB2 Hsap 6246724f00000632 Bradykinin degradation by ACE and bradykin-binding to its receptor (Human) NCBITaxon:9606 gomodel:6246724f00000632/6246724f00000659 GO:0004947 bradykinin receptor activity GO:0042311 vasodilation GO:0005886 plasma membrane false UniProtKB:P13232 IL7 Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000677 GO:0005125 cytokine activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P31785 IL2RG Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000681 GO:0015026 coreceptor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P16871 IL7R Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000685 GO:0004917 interleukin-7 receptor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P52333 JAK3 Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000717 GO:0004713 protein tyrosine kinase activity GO:0038111 interleukin-7-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P23458 JAK1 Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000731 GO:0004713 protein tyrosine kinase activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42229 STAT5A Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/6246724f00000751 GO:0003700 DNA-binding transcription factor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P42224 STAT1 Hsap 6246724f00000675 IL7-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000675/65d7e4ac00000418 GO:0003700 DNA-binding transcription factor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005634 nucleus false UniProtKB:Q969D9 TSLP Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000764 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P16871 IL7R Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000773 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9HC73 CRLF2 Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000776 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000779 GO:0004713 protein tyrosine kinase activity GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000782 GO:0004713 protein tyrosine kinase activity GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P42229 STAT5A Hsap 6246724f00000763 TSLP-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00000763/6246724f00000785 GO:0003700 DNA-binding transcription factor activity GO:0005634 nucleus false UniProtKB:P10145 CXCL8 Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/6246724f00001116 GO:0005125 cytokine activity GO:0038112 interleukin-8-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P25024 CXCR1 Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/6246724f00001190 GO:0004918 interleukin-8 receptor activity GO:0038112 interleukin-8-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P25025 CXCR2 Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/6246724f00001194 GO:0004918 interleukin-8 receptor activity GO:0038112 interleukin-8-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42336 PIK3CA Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/6246724f00001383 GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0038112 interleukin-8-mediated signaling pathway false UniProtKB:P04049 RAF1 Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/6246724f00001392 GO:0004674 protein serine/threonine kinase activity GO:0000165 MAPK cascade false UniProtKB:P63096 GNAI1 Hsap 6246724f00001114 IL8-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:6246724f00001114/69ea894900000813 GO:0003925 G protein activity GO:0038112 interleukin-8-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q5W0Z9 ZDHHC20 Hsap 6246724f00001921 ZDHHC20-ZDHHC9 Palmitoyltransferase activity of Sars-Cov-2 S protein (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:6246724f00001921/6246724f00001922 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0044794 host-mediated activation of viral process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9Y397 ZDHHC9 Hsap 6246724f00001921 ZDHHC20-ZDHHC9 Palmitoyltransferase activity of Sars-Cov-2 S protein (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:6246724f00001921/6246724f00001931 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0044794 host-mediated activation of viral process GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:P0DTC2 S protein Scov2 6246724f00001921 ZDHHC20-ZDHHC9 Palmitoyltransferase activity of Sars-Cov-2 S protein (Human-Sars-Cov-2) NCBITaxon:9606 gomodel:6246724f00001921/6246724f00001945 GO:0039660 structural constituent of virion GO:0019062 virion attachment to host cell GO:0043655 host extracellular region false UniProtKB:P15248 IL9 Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000027 GO:0005125 cytokine activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q01113 IL9R Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000031 GO:0004919 interleukin-9 receptor activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P31785 IL2RG Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000035 GO:0015026 coreceptor activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000040 GO:0004713 protein tyrosine kinase activity GO:0038113 interleukin-9-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P52333 JAK3 Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000044 GO:0004713 protein tyrosine kinase activity GO:0038113 interleukin-9-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P42229 STAT5A Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000048 GO:0003700 DNA-binding transcription factor activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P42224 STAT1 Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000052 GO:0003700 DNA-binding transcription factor activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P40763 STAT3 Hsap 626b20c100000025 IL9-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000025/626b20c100000056 GO:0003700 DNA-binding transcription factor activity GO:0038113 interleukin-9-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P22301 IL10 Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000682 GO:0005125 cytokine activity GO:0140105 interleukin-10-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q13651 IL10RA Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000689 GO:0004920 interleukin-10 receptor activity GO:0140105 interleukin-10-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q08334 IL10RB Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000696 GO:0015026 coreceptor activity GO:0140105 interleukin-10-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000712 GO:0004713 protein tyrosine kinase activity GO:0140105 interleukin-10-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P29597 TYK2 Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000717 GO:0004713 protein tyrosine kinase activity GO:0140105 interleukin-10-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 626b20c100000681 IL10-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100000681/626b20c100000721 GO:0003700 DNA-binding transcription factor activity GO:0140105 interleukin-10-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P20809 IL11 Hsap 626b20c100001212 IL11-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100001212/626b20c100001220 GO:0005125 cytokine activity GO:0038154 interleukin-11-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q14626 IL11RA Hsap 626b20c100001212 IL11-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100001212/626b20c100001250 GO:0004921 interleukin-11 receptor activity GO:0038154 interleukin-11-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P40189 IL6ST Hsap 626b20c100001212 IL11-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100001212/626b20c100001261 GO:0015026 coreceptor activity GO:0038154 interleukin-11-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 626b20c100001212 IL11-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100001212/626b20c100001633 GO:0004713 protein tyrosine kinase activity GO:0038154 interleukin-11-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 626b20c100001212 IL11-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:626b20c100001212/626b20c100001653 GO:0003700 DNA-binding transcription factor activity GO:0038154 interleukin-11-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P29459 IL12A Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/627d95ee00000025 GO:0005515 protein binding GO:0035722 interleukin-12-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P29459 IL12A Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/627d95ee00000032 GO:0005125 cytokine activity GO:0035722 interleukin-12-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P29460 IL12B Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/627d95ee00000037 GO:0005125 cytokine activity GO:0035722 interleukin-12-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P42701 IL12RB1 Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/62900b6400000186 GO:0016517 interleukin-12 receptor activity GO:0035722 interleukin-12-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99665 IL12RB2 Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/62900b6400000197 GO:0015026 coreceptor activity GO:0035722 interleukin-12-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/62900b6400000205 GO:0004713 protein tyrosine kinase activity GO:0035722 interleukin-12-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:Q14765 STAT4 Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/62900b6400000213 GO:0003700 DNA-binding transcription factor activity GO:0035722 interleukin-12-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P29597 TYK2 Hsap 627d95ee00000024 IL12-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000024/62900b6400000218 GO:0004713 protein tyrosine kinase activity GO:0035722 interleukin-12-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40933 IL15 Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000474 GO:0005125 cytokine activity GO:0035723 interleukin-15-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q13261 IL15RA Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000477 GO:0042010 interleukin-15 receptor activity GO:0035723 interleukin-15-mediated signaling pathway GO:0009986 cell surface false UniProtKB:P31785 IL2RG Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000484 GO:0015026 coreceptor activity GO:0035723 interleukin-15-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P14784 IL2RB Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000491 GO:0015026 coreceptor activity GO:0035723 interleukin-15-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000504 GO:0004713 protein tyrosine kinase activity GO:0035723 interleukin-15-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P52333 JAK3 Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000530 GO:0004713 protein tyrosine kinase activity GO:0035723 interleukin-15-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000560 GO:0003700 DNA-binding transcription factor activity GO:0035723 interleukin-15-mediated signaling pathway false UniProtKB:P42229 STAT5A Hsap 627d95ee00000472 IL15 signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00000472/627d95ee00000566 GO:0003700 DNA-binding transcription factor activity GO:0035723 interleukin-15-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P09874 PARP1 Hsap 627d95ee00000718 Regulation of CGAS activity by PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00000718/627d95ee00000719 GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:P78527 PRKDC Hsap 627d95ee00000718 Regulation of CGAS activity by PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00000718/627d95ee00000728 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 627d95ee00000718 Regulation of CGAS activity by PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00000718/627d95ee00000738 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 627d95ee00000757 Regulation of CGAS activity by ZDHHC18 (Human) NCBITaxon:9606 gomodel:627d95ee00000757/627d95ee00000758 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9NUE0 ZDHHC18 Hsap 627d95ee00000757 Regulation of CGAS activity by ZDHHC18 (Human) NCBITaxon:9606 gomodel:627d95ee00000757/627d95ee00000765 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005794 Golgi apparatus false UniProtKB:Q8N884 CGAS Hsap 627d95ee00000757 Regulation of CGAS activity by ZDHHC18 (Human) NCBITaxon:9606 gomodel:627d95ee00000757/627d95ee00001375 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:P09874 PARP1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000776 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity GO:0070213 protein auto-ADP-ribosylation GO:0005634 nucleus false UniProtKB:P09874 PARP1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000785 GO:0003684 damaged DNA binding GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000795 GO:0003682 chromatin binding GO:0006281 DNA repair GO:0000785 chromatin false UniProtKB:Q9NWY4 HPF1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000806 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:0140861 DNA repair-dependent chromatin remodeling GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000817 GO:0140816 NAD+-histone H2BS6 serine ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000824 GO:0140817 NAD+-histone H3S10 serine ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q86WJ1-5 CHD1L Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000841 GO:0160004 poly-ADP-D-ribose modification-dependent protein binding GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q86WJ1-5 CHD1L Hsap 627d95ee00000775 ADP-ribosylation of histones by PARP1 leading to recruitment of CHD1L (Human) NCBITaxon:9606 gomodel:627d95ee00000775/627d95ee00000848 GO:0140658 ATP-dependent chromatin remodeler activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q15366 PCBP2 Hsap 627d95ee00000909 Regulation of CGAS by PCBP2 (Human) NCBITaxon:9606 gomodel:627d95ee00000909/627d95ee00000910 GO:0005515 protein binding GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 627d95ee00000909 Regulation of CGAS by PCBP2 (Human) NCBITaxon:9606 gomodel:627d95ee00000909/627d95ee00000917 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 627d95ee00000909 Regulation of CGAS by PCBP2 (Human) NCBITaxon:9606 gomodel:627d95ee00000909/627d95ee00001368 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N2W9 PIAS4 Hsap 627d95ee00001139 Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) NCBITaxon:9606 gomodel:627d95ee00001139/627d95ee00001140 GO:0061665 SUMO ligase activity GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:P78317 RNF4 Hsap 627d95ee00001139 Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) NCBITaxon:9606 gomodel:627d95ee00001139/627d95ee00001147 GO:0032184 SUMO polymer binding GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:P78317 RNF4 Hsap 627d95ee00001139 Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) NCBITaxon:9606 gomodel:627d95ee00001139/627d95ee00001152 GO:0061630 ubiquitin protein ligase activity GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:P55072 VCP Hsap 627d95ee00001139 Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) NCBITaxon:9606 gomodel:627d95ee00001139/627d95ee00001159 GO:0140036 ubiquitin-modified protein reader activity GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:P09874 PARP1 Hsap 627d95ee00001139 Extraction of PARP1 trapped to chromatin by VCP/p97 following sumoylation by PIAS4 and ubiquitination by RNF4 (Human) NCBITaxon:9606 gomodel:627d95ee00001139/627d95ee00001166 GO:0003682 chromatin binding GO:0006974 DNA damage response GO:0000785 chromatin false UniProtKB:P09874 PARP1 Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001243 GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:O60563 CCNT1 Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001254 GO:0140693 molecular condensate scaffold activity GO:0032968 positive regulation of transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:P50750 CDK9 Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001276 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity GO:0032968 positive regulation of transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:P50750 CDK9 Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001289 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0032968 positive regulation of transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:P18615 NELFE Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001298 GO:0003729 mRNA binding GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false UniProtKB:P18615 NELFE Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001305 GO:0003682 chromatin binding GO:0034244 negative regulation of transcription elongation by RNA polymerase II GO:0000785 chromatin false UniProtKB:P09874 PARP1 Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001312 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0005634 nucleus false UniProtKB:P24928 POLR2A Hsap 627d95ee00001242 Regulation of transcription elongation by the P-TEFb complex, NELFE and PARP1 (Human) NCBITaxon:9606 gomodel:627d95ee00001242/627d95ee00001321 GO:0003899 DNA-directed RNA polymerase activity GO:0006366 transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q16552 IL17A Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001407 GO:0005125 cytokine activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q96F46 IL17RA Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001411 GO:0030368 interleukin-17 receptor activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8NAC3 IL17RC Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001415 GO:0015026 coreceptor activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P0DTC8 ORF8 Scov2 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001419 GO:0005125 cytokine activity GO:0052031 symbiont-mediated perturbation of host defense response GO:0005576 extracellular region false UniProtKB:O43734 TRAF3IP2 Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001720 GO:0061630 ubiquitin protein ligase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001746 GO:0061630 ubiquitin protein ligase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:O43318 MAP3K7 Hsap 627d95ee00001405 Il17A mediated signaling pathway (Human) NCBITaxon:9606 gomodel:627d95ee00001405/627d95ee00001751 GO:0004674 protein serine/threonine kinase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P09874 PARP1 Hsap 627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00001943/627d95ee00001944 GO:0003684 damaged DNA binding GO:0006974 DNA damage response GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00001943/627d95ee00001951 GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00001943/627d95ee00001958 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q9NWY4 HPF1 Hsap 627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00001943/627d95ee00001965 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00001943 Activation of PARP1 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00001943/627d95ee00001978 GO:0042803 protein homodimerization activity GO:0006974 DNA damage response GO:0090734 site of DNA damage false UniProtKB:Q9UGN5 PARP2 Hsap 627d95ee00002030 Activation of PARP2 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00002030/627d95ee00002031 GO:0003684 damaged DNA binding GO:0006974 DNA damage response GO:0090734 site of DNA damage false UniProtKB:Q9UGN5 PARP2 Hsap 627d95ee00002030 Activation of PARP2 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00002030/627d95ee00002040 GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q9UGN5 PARP2 Hsap 627d95ee00002030 Activation of PARP2 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00002030/627d95ee00002047 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q9NWY4 HPF1 Hsap 627d95ee00002030 Activation of PARP2 activity by HPF1 during DNA repair (Human) NCBITaxon:9606 gomodel:627d95ee00002030/627d95ee00002054 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q9UGN5 PARP2 Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002068 GO:0160004 poly-ADP-D-ribose modification-dependent protein binding GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q9UGN5 PARP2 Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002077 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002084 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q8IW19 APLF Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002091 GO:0072572 poly-ADP-D-ribose binding GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q8IW19 APLF Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002098 GO:0140713 histone chaperone activity GO:0140861 DNA repair-dependent chromatin remodeling GO:0090734 site of DNA damage false UniProtKB:O75367 MACROH2A1 Hsap 627d95ee00002067 Regulation of PARP2 activity by PARP1 and recruitment of APLF to DNA damage sites (Human) NCBITaxon:9606 gomodel:627d95ee00002067/627d95ee00002109 GO:0030527 structural constituent of chromatin GO:0006281 DNA repair GO:0090734 site of DNA damage false UniProtKB:Q8N5Y8 PARP16 Hsap 62900b6400000022 Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) NCBITaxon:9606 gomodel:62900b6400000022/62900b6400000023 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity GO:2000766 negative regulation of cytoplasmic translation false UniProtKB:Q8N5Y8 PARP16 Hsap 62900b6400000022 Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) NCBITaxon:9606 gomodel:62900b6400000022/62900b6400000030 GO:0140807 NAD+-protein-glutamate ADP-ribosyltransferase activity GO:2000766 negative regulation of cytoplasmic translation false UniProtKB:Q9BZQ4 NMNAT2 Hsap 62900b6400000022 Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) NCBITaxon:9606 gomodel:62900b6400000022/62900b6400000037 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:2000766 negative regulation of cytoplasmic translation false UniProtKB:P62753 RPS6 Hsap 62900b6400000022 Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) NCBITaxon:9606 gomodel:62900b6400000022/62900b6400000044 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:P83731 RPL24 Hsap 62900b6400000022 Mono-ADP-ribosylation of ribosome subunits by PARP16 (Human) NCBITaxon:9606 gomodel:62900b6400000022/62900b6400000053 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:P09874 PARP1 Hsap 62900b6400000103 Histone poly-ADP-ribosylation of histone H2B at Glu-35 by PARP1 that prevents phosphorylation at of histone H2B at Ser-36 by PRKAA1 (Human) NCBITaxon:9606 gomodel:62900b6400000103/62900b6400000104 GO:0140822 NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity GO:0045892 negative regulation of DNA-templated transcription false UniProtKB:Q9HAN9 NMNAT1 Hsap 62900b6400000103 Histone poly-ADP-ribosylation of histone H2B at Glu-35 by PARP1 that prevents phosphorylation at of histone H2B at Ser-36 by PRKAA1 (Human) NCBITaxon:9606 gomodel:62900b6400000103/62900b6400000111 GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity GO:0045892 negative regulation of DNA-templated transcription false UniProtKB:Q13131 PRKAA1 Hsap 62900b6400000103 Histone poly-ADP-ribosylation of histone H2B at Glu-35 by PARP1 that prevents phosphorylation at of histone H2B at Ser-36 by PRKAA1 (Human) NCBITaxon:9606 gomodel:62900b6400000103/62900b6400000118 GO:0140823 histone H2BS36 kinase activity GO:0045893 positive regulation of DNA-templated transcription false UniProtKB:P35225 IL13 Hsap 62900b6400000265 IL13-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:62900b6400000265/62900b6400000266 GO:0005125 cytokine activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P24394 IL4R Hsap 62900b6400000265 IL13-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:62900b6400000265/62900b6400000273 GO:0016515 interleukin-13 receptor activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P78552 IL13RA1 Hsap 62900b6400000265 IL13-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:62900b6400000265/62900b6400000280 GO:0016515 interleukin-13 receptor activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 62900b6400000265 IL13-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:62900b6400000265/69ea894900000791 GO:0004713 protein tyrosine kinase activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P42226 STAT6 Hsap 62900b6400000265 IL13-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:62900b6400000265/69ea894900000801 GO:0003700 DNA-binding transcription factor activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P53396 ACLY Hsap 62900b6400000500 Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human) NCBITaxon:9606 gomodel:62900b6400000500/62900b6400000511 GO:0003878 ATP citrate synthase activity GO:0006633 fatty acid biosynthetic process GO:0005829 cytosol false UniProtKB:Q92831 KAT2B Hsap 62900b6400000500 Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human) NCBITaxon:9606 gomodel:62900b6400000500/62900b6400000520 GO:0061733 protein-lysine-acetyltransferase activity GO:0045723 positive regulation of fatty acid biosynthetic process false UniProtKB:Q5T4S7 UBR4 Hsap 62900b6400000500 Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human) NCBITaxon:9606 gomodel:62900b6400000500/62900b6400000553 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q8IXJ6 SIRT2 Hsap 62900b6400000500 Regulation of ACLY by acetylation by PCAF/KAT2B and ubiquitination (by UBR4) (Human) NCBITaxon:9606 gomodel:62900b6400000500/62900b6400000560 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0045723 positive regulation of fatty acid biosynthetic process false UniProtKB:Q9UHD0 IL19 Hsap 62900b6400000999 IL19-mediated signaling pathway NCBITaxon:9606 gomodel:62900b6400000999/62900b6400001000 GO:0005125 cytokine activity GO:0140854 interleukin-19-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q6UXL0 IL20RB Hsap 62900b6400000999 IL19-mediated signaling pathway NCBITaxon:9606 gomodel:62900b6400000999/62900b6400001005 GO:0004896 cytokine receptor activity GO:0140854 interleukin-19-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UHF4 IL20RA Hsap 62900b6400000999 IL19-mediated signaling pathway NCBITaxon:9606 gomodel:62900b6400000999/62900b6400001010 GO:0015026 coreceptor activity GO:0140854 interleukin-19-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 62900b6400000999 IL19-mediated signaling pathway NCBITaxon:9606 gomodel:62900b6400000999/62900b6400001652 GO:0004713 protein tyrosine kinase activity GO:0140854 interleukin-19-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 62900b6400000999 IL19-mediated signaling pathway NCBITaxon:9606 gomodel:62900b6400000999/62900b6400001658 GO:0003700 DNA-binding transcription factor activity GO:0140854 interleukin-19-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P19484 TFEB Hsap 62900b6400001385 Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) NCBITaxon:9606 gomodel:62900b6400001385/62900b6400001386 GO:0003700 DNA-binding transcription factor activity GO:1905671 regulation of lysosome organization GO:0005634 nucleus false UniProtKB:P42345 MTOR Hsap 62900b6400001385 Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) NCBITaxon:9606 gomodel:62900b6400001385/62900b6400001398 GO:0004674 protein serine/threonine kinase activity GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P63104 YWHAZ Hsap 62900b6400001385 Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) NCBITaxon:9606 gomodel:62900b6400001385/62900b6400001413 GO:0050815 phosphoserine residue binding GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P63104 YWHAZ Hsap 62900b6400001385 Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) NCBITaxon:9606 gomodel:62900b6400001385/62900b6400001428 GO:0140311 protein sequestering activity GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:A6NK06 ACOD1 Hsap 62900b6400001385 Lysosome biogenesis by TFEB and regulation of cytoplasmic retention via phosphorylation by MTOR or alkylation (Human) NCBITaxon:9606 gomodel:62900b6400001385/62900b6400001471 GO:0047613 aconitate decarboxylase activity GO:0071222 cellular response to lipopolysaccharide GO:0005739 mitochondrion false GO:0017146 NMDA selective glutamate receptor complex 62900b6400001630 PTEN in excitatory hippocampal synapse long-term depression (Human) NCBITaxon:9606 gomodel:62900b6400001630/62900b6400001636 GO:0004972 NMDA glutamate receptor activity GO:0060292 long-term synaptic depression GO:0099092 postsynaptic density, intracellular component false UniProtKB:P78352 DLG4 Hsap 62900b6400001630 PTEN in excitatory hippocampal synapse long-term depression (Human) NCBITaxon:9606 gomodel:62900b6400001630/62900b6400001689 GO:0030160 synaptic receptor adaptor activity GO:0060292 long-term synaptic depression GO:0099092 postsynaptic density, intracellular component false UniProtKB:P60484 PTEN Hsap 62900b6400001630 PTEN in excitatory hippocampal synapse long-term depression (Human) NCBITaxon:9606 gomodel:62900b6400001630/62900b6400001705 GO:0052866 phosphatidylinositol phosphate phosphatase activity GO:0060292 long-term synaptic depression GO:0099092 postsynaptic density, intracellular component false UniProtKB:P35222 CTNNB1 Hsap 62900b6400001630 PTEN in excitatory hippocampal synapse long-term depression (Human) NCBITaxon:9606 gomodel:62900b6400001630/62900b6400001715 GO:0003713 transcription coactivator activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q9NP91 SLC6A20 Hsap 62900b6400001630 PTEN in excitatory hippocampal synapse long-term depression (Human) NCBITaxon:9606 gomodel:62900b6400001630/62900b6400001727 GO:0015187 glycine transmembrane transporter activity GO:1903804 glycine import across plasma membrane GO:0045211 postsynaptic membrane false UniProtKB:Q9NXF8 ZDHHC7 Hsap 62900b6400001749 ZDHHC7 Hsap regulates SCRIB in polarized cell differentiation (Human) NCBITaxon:9606 gomodel:62900b6400001749/62900b6400001751 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0018230 peptidyl-L-cysteine S-palmitoylation false UniProtKB:Q14160 SCRIB Hsap 62900b6400001749 ZDHHC7 Hsap regulates SCRIB in polarized cell differentiation (Human) NCBITaxon:9606 gomodel:62900b6400001749/62900b6400001763 GO:0035591 signaling adaptor activity GO:0030859 polarized epithelial cell differentiation GO:0005911 cell-cell junction false UniProtKB:P46937 YAP1 Hsap 62900b6400001749 ZDHHC7 Hsap regulates SCRIB in polarized cell differentiation (Human) NCBITaxon:9606 gomodel:62900b6400001749/62900b6400002048 GO:0003713 transcription coactivator activity GO:0030859 polarized epithelial cell differentiation false UniProtKB:Q5RIA9 ZNG1E Hsap 62900b6400001836 Activation of METAP1 activity by zinc chaperone ZNG1 (Human) NCBITaxon:9606 gomodel:62900b6400001836/62900b6400001837 GO:0003924 GTPase activity GO:0051604 protein maturation false UniProtKB:Q5RIA9 ZNG1E Hsap 62900b6400001836 Activation of METAP1 activity by zinc chaperone ZNG1 (Human) NCBITaxon:9606 gomodel:62900b6400001836/62900b6400001842 GO:0140827 zinc chaperone activity GO:0051604 protein maturation false UniProtKB:P53582 METAP1 Hsap 62900b6400001836 Activation of METAP1 activity by zinc chaperone ZNG1 (Human) NCBITaxon:9606 gomodel:62900b6400001836/62900b6400001847 GO:0004177 aminopeptidase activity GO:0051604 protein maturation false UniProtKB:Q96EB6 SIRT1 Hsap 62900b6400002448 NSP14 inhibition of SIRT1-NRF2 axis (Human-SARS-COV-2) NCBITaxon:9606 gomodel:62900b6400002448/62900b6400002492 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0006979 response to oxidative stress GO:0005634 nucleus false UniProtKB:P0DTD1-PRO_0000449631 nsp14 Scov2 62900b6400002448 NSP14 inhibition of SIRT1-NRF2 axis (Human-SARS-COV-2) NCBITaxon:9606 gomodel:62900b6400002448/62900b6400002495 GO:0140311 protein sequestering activity GO:0052032 symbiont-mediated perturbation of host inflammatory response GO:0005634 nucleus false UniProtKB:Q16236 NFE2L2 Hsap 62900b6400002448 NSP14 inhibition of SIRT1-NRF2 axis (Human-SARS-COV-2) NCBITaxon:9606 gomodel:62900b6400002448/62900b6400002513 GO:0003700 DNA-binding transcription factor activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P09601 HMOX1 Hsap 62900b6400002448 NSP14 inhibition of SIRT1-NRF2 axis (Human-SARS-COV-2) NCBITaxon:9606 gomodel:62900b6400002448/62900b6400002693 GO:0004392 heme oxygenase (decyclizing) activity GO:0050728 negative regulation of inflammatory response false UniProtKB:P29466 CASP1 Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/62b4ffe300000011 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P55210 CASP7 Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/62b4ffe300000024 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005576 extracellular region false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/62b4ffe300000036 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:P17405 SMPD1 Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/62b4ffe300000047 GO:0061750 acid sphingomyelin phosphodiesterase activity GO:0046513 ceramide biosynthetic process GO:0005576 extracellular region true glycosphingolipid_lysosomal_degradation UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/62b4ffe300000068 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0016020 membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300000010 CASP7 activates SMPD1 to repair Gasdermin pores in intestinal epithelial cells (Human) NCBITaxon:9606 gomodel:62b4ffe300000010/635b1e3e00001542 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P68466 OPG044 VACCW 62b4ffe300000067 Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000067/62b4ffe300000082 GO:0140311 protein sequestering activity GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity false UniProtKB:O00571 DDX3X Hsap 62b4ffe300000067 Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000067/62b4ffe300000116 GO:0035591 signaling adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q14164 IKBKE Hsap 62b4ffe300000067 Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000067/62b4ffe300000174 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q14653-5 IRF3 Hsap 62b4ffe300000067 Poxvirus-OPG044 inhibition of interferon beta induction (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000067/62b4ffe300000210 GO:0001216 DNA-binding transcription activator activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:P10144 GZMB Hsap 62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) NCBITaxon:9606 gomodel:62b4ffe300000081/62b4ffe300000091 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P55210 CASP7 Hsap 62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) NCBITaxon:9606 gomodel:62b4ffe300000081/62b4ffe300000105 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005576 extracellular region false UniProtKB:P17405 SMPD1 Hsap 62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) NCBITaxon:9606 gomodel:62b4ffe300000081/62b4ffe300000154 GO:0061750 acid sphingomyelin phosphodiesterase activity GO:0046513 ceramide biosynthetic process GO:0005576 extracellular region true glycosphingolipid_lysosomal_degradation UniProtKB:P14222 PRF1 Hsap 62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) NCBITaxon:9606 gomodel:62b4ffe300000081/62b4ffe300000195 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0016020 membrane false UniProtKB:P14222 PRF1 Hsap 62b4ffe300000081 CASP7 activates SMPD1 to repair perforin pores in hepatocytes (Human) NCBITaxon:9606 gomodel:62b4ffe300000081/62b4ffe300000218 GO:0022829 wide pore channel activity GO:0140507 granzyme-mediated programmed cell death signaling pathway GO:0016020 membrane false UniProtKB:P0DSV7 OPG002 VAR67 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000251 GO:0005031 tumor necrosis factor receptor activity GO:0005576 extracellular region false UniProtKB:P01375 TNF Hsap 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000303 GO:0005125 cytokine activity GO:0140374 antiviral innate immune response GO:0005576 extracellular region false UniProtKB:P19438 TNFRSF1A Hsap 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000321 GO:0005031 tumor necrosis factor receptor activity GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15628 TRADD Hsap 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000393 GO:0030674 protein-macromolecule adaptor activity GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q13158 FADD Hsap 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000401 GO:0030674 protein-macromolecule adaptor activity GO:0097190 apoptotic signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q12933 TRAF2 Hsap 62b4ffe300000241 Poxvirus-CRMB inhibition of TNF signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000241/62b4ffe300000408 GO:0030674 protein-macromolecule adaptor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P08637 FCGR3A Hsap 62b4ffe300000335 Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human) NCBITaxon:9606 gomodel:62b4ffe300000335/62b4ffe300000336 GO:0140375 immune receptor activity GO:0043320 natural killer cell degranulation GO:0005886 plasma membrane false UniProtKB:P14222 PRF1 Hsap 62b4ffe300000335 Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human) NCBITaxon:9606 gomodel:62b4ffe300000335/62b4ffe300000355 GO:0022829 wide pore channel activity GO:0071806 protein transmembrane transport GO:0005886 plasma membrane false UniProtKB:P10144 GZMB Hsap 62b4ffe300000335 Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human) NCBITaxon:9606 gomodel:62b4ffe300000335/62b4ffe300000371 GO:0004252 serine-type endopeptidase activity GO:0140507 granzyme-mediated programmed cell death signaling pathway GO:0005737 cytoplasm false UniProtKB:P14222 PRF1 Hsap 62b4ffe300000335 Perforin maturation leading to granzyme-mediated programmed cell death signaling pathway (Human) NCBITaxon:9606 gomodel:62b4ffe300000335/62b4ffe300000378 GO:0005509 calcium ion binding GO:0001913 T cell mediated cytotoxicity GO:0001772 immunological synapse false UniProtKB:P07385 OPG199 NCBITaxon:265872 62b4ffe300000418 Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000418/62b4ffe300000419 GO:0140311 protein sequestering activity GO:0039723 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity GO:0005737 cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 62b4ffe300000418 Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000418/62b4ffe300000431 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 62b4ffe300000418 Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000418/62b4ffe300000438 GO:0001216 DNA-binding transcription activator activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q86WV6 STING1 Hsap 62b4ffe300000418 Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000418/62b4ffe300000460 GO:0035591 signaling adaptor activity GO:0032481 positive regulation of type I interferon production GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 62b4ffe300000418 Poxvirus-CRMA inhibition of cGAS-STING signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000418/62b4ffe300000480 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:P21605 OPG065 VACCW 62b4ffe300000504 Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000504/62b4ffe300000505 GO:0003723 RNA binding GO:0042783 symbiont-mediated evasion of host immune response GO:0005737 cytoplasm false UniProtKB:Q9H171 ZBP1 Hsap 62b4ffe300000504 Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000504/62b4ffe300000514 GO:0003723 RNA binding GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9Y572 RIPK3 Hsap 62b4ffe300000504 Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000504/62b4ffe300000522 GO:0004674 protein serine/threonine kinase activity GO:0097527 necroptotic signaling pathway GO:0005634 nucleus false UniProtKB:Q8NB16 MLKL Hsap 62b4ffe300000504 Poxvirus-OPG065 inhibition of ZBP1-mediated necroptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000504/62b4ffe300000706 GO:0004674 protein serine/threonine kinase activity GO:0097528 execution phase of necroptosis GO:0005886 plasma membrane false UniProtKB:Q13616 CUL1 Hsap 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000738 GO:0031625 ubiquitin protein ligase binding GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P01574 IFNB1 Hsap 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000750 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P09914 IFIT1 Hsap 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000758 GO:0003723 RNA binding GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P17372 OPG035 VACCW 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000766 GO:0060090 molecular adaptor activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0005737 cytoplasm false UniProtKB:O14879 IFIT3 Hsap 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000826 GO:0003723 RNA binding GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P09913 IFIT2 Hsap 62b4ffe300000717 Poxvirus-OPG025 inhibition of antiviral IFITs (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000717/62b4ffe300000880 GO:0003723 RNA binding GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P55210 CASP7 Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300000785 GO:0004197 cysteine-type endopeptidase activity GO:0097194 execution phase of apoptosis GO:0005829 cytosol false UniProtKB:Q14790 CASP8 Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300000799 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P55211 CASP9 Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300000815 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:Q92851 CASP10 Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300000836 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P98170 XIAP Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300000864 GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0043066 negative regulation of apoptotic process GO:0005829 cytosol false UniProtKB:Q13177 PAK2 Hsap 62b4ffe300000784 Involvement of CASP7 in apoptosis, its activation by initiator caspases (CASP8, CASP9 and CASP10) and regulation by XIAP and PAK2 (Human) NCBITaxon:9606 gomodel:62b4ffe300000784/62b4ffe300001008 GO:0004674 protein serine/threonine kinase activity GO:0043066 negative regulation of apoptotic process GO:0005829 cytosol false UniProtKB:P05161 ISG15 Hsap 62b4ffe300000906 Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000906/62b4ffe300000942 GO:0031386 protein tag activity GO:0032020 ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:P41226 UBA7 Hsap 62b4ffe300000906 Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000906/62b4ffe300000951 GO:0019782 ISG15 activating enzyme activity GO:0032020 ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:O14933 UBE2L6 Hsap 62b4ffe300000906 Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000906/62b4ffe300000958 GO:0042296 ISG15 transferase activity GO:0032020 ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:Q9UII4 HERC5 Hsap 62b4ffe300000906 Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000906/62b4ffe300000965 GO:0061662 ISG15 ligase activity GO:0032020 ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:P21605 OPG065 VACCW 62b4ffe300000906 Poxvirus-OPG065 inhibition of ISG15 conjugation (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300000906/62b4ffe300000972 GO:0140311 protein sequestering activity GO:0039579 symbiont-mediated suppression of host ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:P42574 CASP3 Hsap 62b4ffe300001804 Cleavage and inactivation of PARP1 by CASP3 and/or CASP7 during the execution phase of apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300001804/62b4ffe300001805 GO:0004197 cysteine-type endopeptidase activity GO:0030163 protein catabolic process GO:0005634 nucleus false UniProtKB:P55210 CASP7 Hsap 62b4ffe300001804 Cleavage and inactivation of PARP1 by CASP3 and/or CASP7 during the execution phase of apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300001804/62b4ffe300001814 GO:0004197 cysteine-type endopeptidase activity GO:0030163 protein catabolic process GO:0005634 nucleus false UniProtKB:P09874 PARP1 Hsap 62b4ffe300001804 Cleavage and inactivation of PARP1 by CASP3 and/or CASP7 during the execution phase of apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300001804/62b4ffe300001823 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0070212 protein poly-ADP-ribosylation GO:0005634 nucleus false UniProtKB:P55210 CASP7 Hsap 62b4ffe300001804 Cleavage and inactivation of PARP1 by CASP3 and/or CASP7 during the execution phase of apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300001804/62b4ffe300001881 GO:0003723 RNA binding GO:0097194 execution phase of apoptosis GO:0005634 nucleus false UniProtKB:P29466 CASP1 Hsap 62b4ffe300001832 Activation of CASP7 by CASP1 in response to lipopolysaccharide, leading to cleavage and degradation of PARP1 by CASP7 (Human) NCBITaxon:9606 gomodel:62b4ffe300001832/62b4ffe300001833 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P55210 CASP7 Hsap 62b4ffe300001832 Activation of CASP7 by CASP1 in response to lipopolysaccharide, leading to cleavage and degradation of PARP1 by CASP7 (Human) NCBITaxon:9606 gomodel:62b4ffe300001832/62b4ffe300001844 GO:0004197 cysteine-type endopeptidase activity GO:0030163 protein catabolic process GO:0005634 nucleus false UniProtKB:P09874 PARP1 Hsap 62b4ffe300001832 Activation of CASP7 by CASP1 in response to lipopolysaccharide, leading to cleavage and degradation of PARP1 by CASP7 (Human) NCBITaxon:9606 gomodel:62b4ffe300001832/62b4ffe300001857 GO:0003950 NAD+ poly-ADP-ribosyltransferase activity GO:0070212 protein poly-ADP-ribosylation GO:0005634 nucleus false UniProtKB:P55210 CASP7 Hsap 62b4ffe300002284 Phosphorylation of YY1 by CK2 (CSNK2A1) protects YY1 from CASP7-mediated degradation during apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002284/62b4ffe300002286 GO:0004197 cysteine-type endopeptidase activity GO:0030163 protein catabolic process GO:0005634 nucleus false UniProtKB:P68400 CSNK2A1 Hsap 62b4ffe300002284 Phosphorylation of YY1 by CK2 (CSNK2A1) protects YY1 from CASP7-mediated degradation during apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002284/62b4ffe300002305 GO:0004674 protein serine/threonine kinase activity GO:0050821 protein stabilization GO:0005634 nucleus false UniProtKB:P25490 YY1 Hsap 62b4ffe300002284 Phosphorylation of YY1 by CK2 (CSNK2A1) protects YY1 from CASP7-mediated degradation during apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002284/62b4ffe300002315 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:A0A0H2US87 ospC3 SHIFL 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/62b4ffe300002386 GO:0140740 ADP-riboxanase-[protein] activity GO:0052041 symbiont-mediated suppression of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:P49662 CASP4 Hsap 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/62b4ffe300002395 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/62b4ffe300002404 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P49662 CASP4 Hsap 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/62b4ffe300002413 GO:0004197 cysteine-type endopeptidase activity GO:0016540 protein autoprocessing false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/635b1e3e00001533 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:A0A0H2US87 ospC3 SHIFL 62b4ffe300002385 Arginine ADP-riboxanation of CASP4 by S.flexneri OspC3 that blocks CASP4 activity and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300002385/654d809000002682 GO:0005516 calmodulin binding GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:P42224 STAT1 Hsap 62b4ffe300002753 Poxvirus-OPG106 inhibition of interferon-gamma signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002753/62b4ffe300002754 GO:0003700 DNA-binding transcription factor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P07239 OPG106 VACCW 62b4ffe300002753 Poxvirus-OPG106 inhibition of interferon-gamma signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002753/62b4ffe300002763 GO:0016791 phosphatase activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P15260 IFNGR1 Hsap 62b4ffe300002753 Poxvirus-OPG106 inhibition of interferon-gamma signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002753/62b4ffe300002789 GO:0004906 type II interferon receptor activity GO:0060333 type II interferon-mediated signaling pathway GO:0016020 membrane false UniProtKB:P01579 IFNG Hsap 62b4ffe300002753 Poxvirus-OPG106 inhibition of interferon-gamma signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002753/62b4ffe300002800 GO:0005125 cytokine activity GO:0060333 type II interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P25213 OPG204 VACCW 62b4ffe300002814 Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002814/62b4ffe300002815 GO:0140319 receptor decoy activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P01563 IFNA2 Hsap 62b4ffe300002814 Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002814/62b4ffe300002833 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P17181 IFNAR1 Hsap 62b4ffe300002814 Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002814/62b4ffe300002844 GO:0004905 type I interferon receptor activity GO:0060337 type I interferon-mediated signaling pathway GO:0016020 membrane false UniProtKB:P48551 IFNAR2 Hsap 62b4ffe300002814 Poxvirus-OPG204 inhibition of type I interferon signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002814/62b4ffe300002888 GO:0004905 type I interferon receptor activity GO:0060337 type I interferon-mediated signaling pathway GO:0016020 membrane false UniProtKB:P18378 VACWR034 VACCW 62b4ffe300002896 Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002896/62b4ffe300002897 GO:0140311 protein sequestering activity GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling GO:0005737 cytoplasm false UniProtKB:P19525 EIF2AK2 Hsap 62b4ffe300002896 Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002896/62b4ffe300002904 GO:0004672 protein kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9BY44 EIF2A Hsap 62b4ffe300002896 Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002896/62b4ffe300002909 GO:0003743 translation initiation factor activity GO:0006413 translational initiation GO:0005737 cytoplasm false UniProtKB:P20042 EIF2S2 Hsap 62b4ffe300002896 Poxvirus-OPG043 inhibition of host PKR (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300002896/62b4ffe300003057 GO:0003743 translation initiation factor activity GO:0006413 translational initiation GO:0005737 cytoplasm false UniProtKB:Q92844 TANK Hsap 62b4ffe300003074 Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003074/62b4ffe300003075 GO:0060090 molecular adaptor activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:P17362 OPG029 VACCW 62b4ffe300003074 Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003074/62b4ffe300003084 GO:0140311 protein sequestering activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 62b4ffe300003074 Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003074/62b4ffe300003097 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 62b4ffe300003074 Poxvirus-OPG029 inhibition of host TBK1 adaptor TANK (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003074/62b4ffe300003110 GO:0003700 DNA-binding transcription factor activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:P56524 HDAC4 Hsap 62b4ffe300003248 Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003248/62b4ffe300003249 GO:0060090 molecular adaptor activity GO:0060337 type I interferon-mediated signaling pathway GO:0000785 chromatin false UniProtKB:P52630 STAT2 Hsap 62b4ffe300003248 Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003248/62b4ffe300003264 GO:0003700 DNA-binding transcription factor activity GO:0060337 type I interferon-mediated signaling pathway GO:0000785 chromatin false UniProtKB:P23458 JAK1 Hsap 62b4ffe300003248 Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003248/62b4ffe300003272 GO:0004713 protein tyrosine kinase activity GO:0060337 type I interferon-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P17362 OPG029 VACCW 62b4ffe300003248 Poxvirus-OPG029 inhibition of host HDAC4_STAT2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003248/62b4ffe300003288 GO:0140311 protein sequestering activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P07396 OPG062 VACCW 62b4ffe300003321 Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003321/62b4ffe300003322 GO:0140313 molecular sequestering activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q6R327 RICTOR Hsap 62b4ffe300003321 Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003321/62b4ffe300003344 GO:0043539 protein serine/threonine kinase activator activity GO:0038203 TORC2 signaling GO:0005794 Golgi apparatus false UniProtKB:P31749 AKT1 Hsap 62b4ffe300003321 Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003321/62b4ffe300003351 GO:0004674 protein serine/threonine kinase activity GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005737 cytoplasm false UniProtKB:Q8N884 CGAS Hsap 62b4ffe300003321 Poxvirus-OPG062 inhibition of host mTOR/cGAS signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003321/62b4ffe300003358 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:P33681 CD80 Hsap 62b4ffe300003382 Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003382/62b4ffe300003383 GO:0048018 receptor ligand activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P42081 CD86 Hsap 62b4ffe300003382 Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003382/62b4ffe300003390 GO:0048018 receptor ligand activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:Q80HY2 OPG038 VACCW 62b4ffe300003382 Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003382/62b4ffe300003397 GO:0140311 protein sequestering activity GO:0052085 symbiont-mediated suppression of host T-cell mediated immune response GO:0005576 extracellular region false UniProtKB:P33681 CD80 Hsap 62b4ffe300003382 Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003382/62b4ffe300003548 GO:0048018 receptor ligand activity GO:0002710 negative regulation of T cell mediated immunity GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 62b4ffe300003382 Poxvirus-OPG038 inhibition of host CD80/CD86 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003382/62b4ffe300003579 GO:0015026 coreceptor activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P24356 OPG045 VACCW 62b4ffe300003618 Poxvirus-OPG045 inhibition of host BAK-mediated apoptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003618/62b4ffe300003619 GO:0140311 protein sequestering activity GO:0033668 symbiont-mediated suppression of host apoptosis GO:0005739 mitochondrion false UniProtKB:Q16611 BAK1 Hsap 62b4ffe300003618 Poxvirus-OPG045 inhibition of host BAK-mediated apoptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003618/62b4ffe300003631 GO:0015288 porin activity GO:0097193 intrinsic apoptotic signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:P55211 CASP9 Hsap 62b4ffe300003618 Poxvirus-OPG045 inhibition of host BAK-mediated apoptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003618/62b4ffe300003639 GO:0004197 cysteine-type endopeptidase activity GO:0097193 intrinsic apoptotic signaling pathway GO:0005739 mitochondrion false UniProtKB:P42574 CASP3 Hsap 62b4ffe300003618 Poxvirus-OPG045 inhibition of host BAK-mediated apoptosis (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003618/62b4ffe300003647 GO:0004197 cysteine-type endopeptidase activity GO:0097193 intrinsic apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:O14920 IKBKB Hsap 62b4ffe300003679 Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003679/62b4ffe300003688 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P24772 OPG200 VACCW 62b4ffe300003679 Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003679/62b4ffe300004217 GO:0140313 molecular sequestering activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300003679 Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003679/62b4ffe300004306 GO:0140311 protein sequestering activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 62b4ffe300003679 Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003679/62b4ffe300004335 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 62b4ffe300003679 Poxvirus-OPG200 inhibition of host IKBKE-mediated NF-Kappa-B (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300003679/62b4ffe300004354 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q96J02 ITCH Hsap 62b4ffe300003746 CXCR4 desensitization by ENTREP1 and ITCH (Human) NCBITaxon:9606 gomodel:62b4ffe300003746/62b4ffe300003748 GO:0061630 ubiquitin protein ligase activity GO:0031623 receptor internalization GO:0005886 plasma membrane false UniProtKB:Q15884 ENTREP1 Hsap 62b4ffe300003746 CXCR4 desensitization by ENTREP1 and ITCH (Human) NCBITaxon:9606 gomodel:62b4ffe300003746/62b4ffe300003751 GO:1990757 ubiquitin ligase activator activity GO:0031623 receptor internalization GO:0005886 plasma membrane false UniProtKB:P61073 CXCR4 Hsap 62b4ffe300003746 CXCR4 desensitization by ENTREP1 and ITCH (Human) NCBITaxon:9606 gomodel:62b4ffe300003746/62b4ffe300003825 GO:0038147 C-X-C motif chemokine 12 receptor activity GO:0038160 CXCL12-activated CXCR4 signaling pathway false UniProtKB:P01574 IFNB1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003755 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P17181 IFNAR1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003768 GO:0004905 type I interferon receptor activity GO:0035458 cellular response to interferon-beta GO:0005886 plasma membrane false UniProtKB:P48551 IFNAR2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003808 GO:0004905 type I interferon receptor activity GO:0035458 cellular response to interferon-beta GO:0005886 plasma membrane false UniProtKB:P29597 TYK2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003831 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0019897 extrinsic component of plasma membrane false UniProtKB:P23458 JAK1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003846 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P29597 TYK2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003871 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P17181 IFNAR1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003911 GO:0008269 JAK pathway signal transduction adaptor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P29597 TYK2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300003944 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P42224 STAT1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004006 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P23458 JAK1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004014 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004047 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P48551 IFNAR2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004077 GO:0008269 JAK pathway signal transduction adaptor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P17181 IFNAR1 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004120 GO:0008269 JAK pathway signal transduction adaptor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P29597 TYK2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004140 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005886 plasma membrane false UniProtKB:P52630 STAT2 Hsap 62b4ffe300003747 Response to IFN-beta, leading to JAK-STAT activation (Human) NCBITaxon:9606 gomodel:62b4ffe300003747/62b4ffe300004187 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P24770 OPG193 VACCW 62b4ffe300004362 Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300004362/62b4ffe300004363 GO:0140319 receptor decoy activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0005576 extracellular region false UniProtKB:P01579 IFNG Hsap 62b4ffe300004362 Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300004362/62b4ffe300004371 GO:0005125 cytokine activity GO:0038196 type III interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P15260 IFNGR1 Hsap 62b4ffe300004362 Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300004362/62b4ffe300004378 GO:0004906 type II interferon receptor activity GO:0038196 type III interferon-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P38484 IFNGR2 Hsap 62b4ffe300004362 Poxvirus-OPG193 interferon gamma decoy receptor (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300004362/62b4ffe300004392 GO:0004906 type II interferon receptor activity GO:0038196 type III interferon-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300004489 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) NCBITaxon:9606 gomodel:62b4ffe300004489/62b4ffe300004564 GO:0005509 calcium ion binding GO:0071346 cellular response to type II interferon false UniProtKB:Q9UQM7 CAMK2A Hsap 62b4ffe300004489 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) NCBITaxon:9606 gomodel:62b4ffe300004489/62b4ffe300004580 GO:0004683 calcium/calmodulin-dependent protein kinase activity GO:0071346 cellular response to type II interferon false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300004489 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) NCBITaxon:9606 gomodel:62b4ffe300004489/62b4ffe300004590 GO:0043539 protein serine/threonine kinase activator activity GO:0071346 cellular response to type II interferon false UniProtKB:P42224 STAT1 Hsap 62b4ffe300004489 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) NCBITaxon:9606 gomodel:62b4ffe300004489/62b4ffe300004627 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0071346 cellular response to type II interferon GO:0005634 nucleus false UniProtKB:Q09472 EP300 Hsap 62b4ffe300004489 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-gamma (Human) NCBITaxon:9606 gomodel:62b4ffe300004489/62b4ffe300004844 GO:0003713 transcription coactivator activity GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300004525 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human) NCBITaxon:9606 gomodel:62b4ffe300004525/62b4ffe300004526 GO:0005509 calcium ion binding GO:0035458 cellular response to interferon-beta false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300004525 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human) NCBITaxon:9606 gomodel:62b4ffe300004525/62b4ffe300004533 GO:0043539 protein serine/threonine kinase activator activity GO:0035458 cellular response to interferon-beta false UniProtKB:Q9UQM7 CAMK2A Hsap 62b4ffe300004525 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human) NCBITaxon:9606 gomodel:62b4ffe300004525/62b4ffe300004542 GO:0004683 calcium/calmodulin-dependent protein kinase activity GO:0035458 cellular response to interferon-beta false UniProtKB:P42224 STAT1 Hsap 62b4ffe300004525 Regulation of the JAK-STAT pathway by calmodulin in response to interferon-beta (Human) NCBITaxon:9606 gomodel:62b4ffe300004525/62b4ffe300004549 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0035458 cellular response to interferon-beta GO:0005634 nucleus false UniProtKB:Q14653 IRF3 Hsap 62b4ffe300004589 USP22 activation of IRF3 via KPNA2 stabilization (Human) NCBITaxon:9606 gomodel:62b4ffe300004589/62b4ffe300004611 GO:0003700 DNA-binding transcription factor activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q9UHD2 TBK1 Hsap 62b4ffe300004589 USP22 activation of IRF3 via KPNA2 stabilization (Human) NCBITaxon:9606 gomodel:62b4ffe300004589/62b4ffe300004638 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q13114 TRAF3 Hsap 62b4ffe300004589 USP22 activation of IRF3 via KPNA2 stabilization (Human) NCBITaxon:9606 gomodel:62b4ffe300004589/62b4ffe300004651 GO:0004842 ubiquitin-protein transferase activity GO:0032481 positive regulation of type I interferon production GO:0005739 mitochondrion false UniProtKB:Q9UPT9 USP22 Hsap 62b4ffe300004589 USP22 activation of IRF3 via KPNA2 stabilization (Human) NCBITaxon:9606 gomodel:62b4ffe300004589/657ba49f00001976 GO:0004843 cysteine-type deubiquitinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:P52292 KPNA2 Hsap 62b4ffe300004589 USP22 activation of IRF3 via KPNA2 stabilization (Human) NCBITaxon:9606 gomodel:62b4ffe300004589/657ba49f00001985 GO:0061608 nuclear import signal receptor activity GO:0032481 positive regulation of type I interferon production GO:0031965 nuclear membrane false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004857 Arginine ADP-riboxanation of CASP7 by by C.violaceum CopC blocks CASP7 activity and apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004857/62b4ffe300004858 GO:0140740 ADP-riboxanase-[protein] activity GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004857 Arginine ADP-riboxanation of CASP7 by by C.violaceum CopC blocks CASP7 activity and apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004857/62b4ffe300004869 GO:0005516 calmodulin binding GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:P55210 CASP7 Hsap 62b4ffe300004857 Arginine ADP-riboxanation of CASP7 by by C.violaceum CopC blocks CASP7 activity and apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004857/62b4ffe300004881 GO:0004197 cysteine-type endopeptidase activity GO:0097194 execution phase of apoptosis GO:0005829 cytosol false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004892 Arginine ADP-riboxanation of CASP8 by by C.violaceum CopC blocks CASP8 activity and extrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004892/62b4ffe300004893 GO:0005516 calmodulin binding GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004892 Arginine ADP-riboxanation of CASP8 by by C.violaceum CopC blocks CASP8 activity and extrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004892/62b4ffe300004905 GO:0140740 ADP-riboxanase-[protein] activity GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:Q14790 CASP8 Hsap 62b4ffe300004892 Arginine ADP-riboxanation of CASP8 by by C.violaceum CopC blocks CASP8 activity and extrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004892/62b4ffe300004917 GO:0004197 cysteine-type endopeptidase activity GO:0097191 extrinsic apoptotic signaling pathway GO:0005829 cytosol false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004953 Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004953/62b4ffe300004954 GO:0005516 calmodulin binding GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300004953 Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004953/62b4ffe300004966 GO:0140740 ADP-riboxanase-[protein] activity GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:P42574 CASP3 Hsap 62b4ffe300004953 Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004953/62b4ffe300004980 GO:0004197 cysteine-type endopeptidase activity GO:0097194 execution phase of apoptosis GO:0005829 cytosol false UniProtKB:P42574 CASP3 Hsap 62b4ffe300004953 Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004953/62b4ffe300004989 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation false UniProtKB:O60443-PRO_0000442786 GSDME-GSDME-NT Hsap 62b4ffe300004953 Arginine ADP-riboxanation of CASP3 by by C.violaceum CopC that blocks CASP3 activity, subsequent apoptosis and pyroptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300004953/62b4ffe300005000 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0016020 membrane false UniProtKB:O00206 TLR4 Hsap 62b4ffe300005014 Poxvirus-OPG176 inhibition of hostTLR4 signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005014/62b4ffe300005015 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P58753 TIRAP Hsap 62b4ffe300005014 Poxvirus-OPG176 inhibition of hostTLR4 signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005014/62b4ffe300005022 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:Q99836 MYD88 Hsap 62b4ffe300005014 Poxvirus-OPG176 inhibition of hostTLR4 signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005014/62b4ffe300005039 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P26672 OPG176 VACCW 62b4ffe300005014 Poxvirus-OPG176 inhibition of hostTLR4 signaling (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005014/62b4ffe300005047 GO:0140311 protein sequestering activity GO:0039722 symbiont-mediated suppression of host toll-like receptor signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300005060 Arginine ADP-riboxanation of CASP9 by by C.violaceum CopC that blocks CASP9 activity and intrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300005060/62b4ffe300005061 GO:0005516 calmodulin binding GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:Q7NWF2 copC NCBITaxon:243365 62b4ffe300005060 Arginine ADP-riboxanation of CASP9 by by C.violaceum CopC that blocks CASP9 activity and intrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300005060/62b4ffe300005073 GO:0140740 ADP-riboxanase-[protein] activity GO:0052040 symbiont-mediated perturbation of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:P55211 CASP9 Hsap 62b4ffe300005060 Arginine ADP-riboxanation of CASP9 by by C.violaceum CopC that blocks CASP9 activity and intrinsic apoptosis (Human) NCBITaxon:9606 gomodel:62b4ffe300005060/62b4ffe300005087 GO:0004197 cysteine-type endopeptidase activity GO:0097193 intrinsic apoptotic signaling pathway GO:0005829 cytosol false UniProtKB:Q14116 IL18 Hsap 62b4ffe300005096 Poxvirus-OPG022 inhibition of host IL18 signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005096/62b4ffe300005097 GO:0005125 cytokine activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P17357 OPG022 VACCW 62b4ffe300005096 Poxvirus-OPG022 inhibition of host IL18 signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005096/62b4ffe300005104 GO:0140319 receptor decoy activity GO:0039518 obsolete suppression by virus of host cytokine activity GO:0005576 extracellular region false UniProtKB:Q13478 IL18R1 Hsap 62b4ffe300005096 Poxvirus-OPG022 inhibition of host IL18 signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005096/62b4ffe300005117 GO:0042008 interleukin-18 receptor activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O95256 IL18RAP Hsap 62b4ffe300005096 Poxvirus-OPG022 inhibition of host IL18 signaling pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005096/62b4ffe300005130 GO:0015026 coreceptor activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01225 OPG188 VACCW 62b4ffe300005140 Poxvirus-OPG188 inhibition of host cGAS-STING pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005140/62b4ffe300005149 GO:0004518 nuclease activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0030430 host cell cytoplasm false UniProtKB:Q8N884 CGAS Hsap 62b4ffe300005140 Poxvirus-OPG188 inhibition of host cGAS-STING pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005140/62b4ffe300005163 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0002218 activation of innate immune response GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 62b4ffe300005140 Poxvirus-OPG188 inhibition of host cGAS-STING pathway (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005140/62b4ffe300005171 GO:0061507 2',3'-cyclic GMP-AMP binding GO:0002218 activation of innate immune response GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q76QY7 OPG003 VAR67 62b4ffe300005181 Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005181/62b4ffe300005224 GO:0140311 protein sequestering activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0042025 host cell nucleus false UniProtKB:P19838 NFKB1 Hsap 62b4ffe300005181 Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005181/62b4ffe300005231 GO:0003700 DNA-binding transcription factor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:O14920 IKBKB Hsap 62b4ffe300005181 Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005181/62b4ffe300005244 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300005181 Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005181/62b4ffe300005251 GO:0140311 protein sequestering activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q04206 RELA Hsap 62b4ffe300005181 Poxvirus-OPG003 inhibition of host NF-kappa-B pathway via NFKB1 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005181/62b4ffe300005275 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P68707 OPG058 VACCW 62b4ffe300005283 Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005283/62b4ffe300005284 GO:0140311 protein sequestering activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0042025 host cell nucleus false UniProtKB:Q92793 CREBBP Hsap 62b4ffe300005283 Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005283/62b4ffe300005291 GO:0004402 histone acetyltransferase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:Q04206 RELA Hsap 62b4ffe300005283 Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005283/62b4ffe300005309 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300005283 Poxvirus-OPG058 inhibition of host NF-kappa-B via CBP (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005283/62b4ffe300005332 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y297 BTRC Hsap 62b4ffe300005342 Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005342/62b4ffe300005343 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300005342 Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005342/62b4ffe300005355 GO:0140311 protein sequestering activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P31037 VACWR175 VACCW 62b4ffe300005342 Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005342/62b4ffe300005363 GO:0140311 protein sequestering activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0030430 host cell cytoplasm false UniProtKB:Q04206 RELA Hsap 62b4ffe300005342 Poxvirus-OPG179 inhibition of host NF-kappa-B via BTRC (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005342/62b4ffe300005376 GO:0003700 DNA-binding transcription factor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P52292 KPNA2 Hsap 62b4ffe300005389 Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005389/62b4ffe300005390 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus GO:0031965 nuclear membrane false UniProtKB:P24768 KBTB1 VACCW 62b4ffe300005389 Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005389/62b4ffe300005397 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0030430 host cell cytoplasm false UniProtKB:Q04206 RELA Hsap 62b4ffe300005389 Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005389/62b4ffe300005410 GO:0003700 DNA-binding transcription factor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300005389 Poxvirus-OPG184 inhibition of host NF-kappa-B via KPNA2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005389/62b4ffe300005419 GO:0140311 protein sequestering activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:A0A0H2US87 ospC3 SHIFL 62b4ffe300005437 Inhibition of the JAK-STAT pathway by S.flexneri OspC3 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005437/62b4ffe300005438 GO:0005516 calmodulin binding GO:0075135 symbiont-mediated suppression of host calcium-mediated signal transduction GO:0030430 host cell cytoplasm false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300005437 Inhibition of the JAK-STAT pathway by S.flexneri OspC3 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005437/62b4ffe300005449 GO:0005509 calcium ion binding GO:0035458 cellular response to interferon-beta false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300005437 Inhibition of the JAK-STAT pathway by S.flexneri OspC3 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005437/62b4ffe300005456 GO:0043539 protein serine/threonine kinase activator activity GO:0035458 cellular response to interferon-beta false UniProtKB:Q8VSJ7 ospC1 SHIFL 62b4ffe300005467 Inhibition of the JAK-STAT pathway by S.flexneri OspC1 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005467/62b4ffe300005468 GO:0005516 calmodulin binding GO:0075135 symbiont-mediated suppression of host calcium-mediated signal transduction GO:0030430 host cell cytoplasm false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300005467 Inhibition of the JAK-STAT pathway by S.flexneri OspC1 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005467/62b4ffe300005488 GO:0005509 calcium ion binding GO:0035458 cellular response to interferon-beta false UniProtKB:P0DP23 CALM1 Hsap 62b4ffe300005467 Inhibition of the JAK-STAT pathway by S.flexneri OspC1 that blocks calcium-binding to calmodulin (Human) NCBITaxon:9606 gomodel:62b4ffe300005467/62b4ffe300005495 GO:0043539 protein serine/threonine kinase activator activity GO:0035458 cellular response to interferon-beta false UniProtKB:Q9Y4K3 TRAF6 Hsap 62b4ffe300005506 Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005506/62b4ffe300005507 GO:0061630 ubiquitin protein ligase activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O43187 IRAK2 Hsap 62b4ffe300005506 Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005506/62b4ffe300005516 GO:0060090 molecular adaptor activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 62b4ffe300005506 Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005506/62b4ffe300005535 GO:0004707 MAP kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O15111 CHUK Hsap 62b4ffe300005506 Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005506/62b4ffe300005551 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q01220 VACWR178 VACCW 62b4ffe300005506 Poxvirus-OPG182 inhibition of host NF-kappa-B via IRAK2 (Human-Poxvirus) NCBITaxon:9606 gomodel:62b4ffe300005506/62b4ffe300005564 GO:0140311 protein sequestering activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade GO:0030430 host cell cytoplasm false UniProtKB:P04413 US3 HHV11 62b4ffe300005623 HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005623/62b4ffe300005624 GO:0140311 protein sequestering activity GO:0052085 symbiont-mediated suppression of host T-cell mediated immune response GO:0030430 host cell cytoplasm false UniProtKB:O43561 LAT Hsap 62b4ffe300005623 HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005623/62b4ffe300005631 GO:0030159 signaling receptor complex adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 62b4ffe300005623 HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005623/62b4ffe300005644 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 62b4ffe300005623 HHV1-US3 inhibition of host TCR signaling via LAT (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005623/62b4ffe300005657 GO:0061630 ubiquitin protein ligase activity GO:0050852 T cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P04413 US3 HHV11 62b4ffe300005697 HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005697/62b4ffe300005698 GO:0004674 protein serine/threonine kinase activity GO:0039540 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of RIG-I activity GO:0030430 host cell cytoplasm false UniProtKB:O95786 RIGI Hsap 62b4ffe300005697 HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005697/62b4ffe300005710 GO:0038187 pattern recognition receptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14258 TRIM25 Hsap 62b4ffe300005697 HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005697/62b4ffe300005717 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 62b4ffe300005697 HHV1-US3 inhibition of host RIG-I signaling (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005697/62b4ffe300005731 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0031966 mitochondrial membrane false UniProtKB:P04413 US3 HHV11 62b4ffe300005953 HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005953/62b4ffe300005954 GO:0004674 protein serine/threonine kinase activity GO:1900181 negative regulation of protein localization to nucleus GO:0030430 host cell cytoplasm false UniProtKB:P25963 NFKBIA Hsap 62b4ffe300005953 HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005953/62b4ffe300005966 GO:0140311 protein sequestering activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P52292 KPNA2 Hsap 62b4ffe300005953 HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005953/62b4ffe300005978 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus GO:0031965 nuclear membrane false UniProtKB:Q04206 RELA Hsap 62b4ffe300005953 HHV1-US3 inhibition of host NF-kappa-B signaling via RELA (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300005953/62b4ffe300005992 GO:0003700 DNA-binding transcription factor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P04413 US3 HHV11 62b4ffe300006001 HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006001/62b4ffe300006002 GO:0004674 protein serine/threonine kinase activity GO:0042308 negative regulation of protein import into nucleus GO:0030430 host cell cytoplasm false UniProtKB:O00410 IPO5 Hsap 62b4ffe300006001 HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006001/62b4ffe300006044 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus GO:0031965 nuclear membrane false UniProtKB:Q14653 IRF3 Hsap 62b4ffe300006001 HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006001/62b4ffe300006081 GO:0003700 DNA-binding transcription factor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q9UHD2 TBK1 Hsap 62b4ffe300006001 HHV1-US3 inhibition of host IRF3 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006001/62b4ffe300006092 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P0C0J1 speB STRP1 62b4ffe300006086 Activation of IL1B following cleavage by S.pyogenes speB, leading to inflammatory response (Human) NCBITaxon:9606 gomodel:62b4ffe300006086/62b4ffe300006102 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P01584 IL1B Hsap 62b4ffe300006086 Activation of IL1B following cleavage by S.pyogenes speB, leading to inflammatory response (Human) NCBITaxon:9606 gomodel:62b4ffe300006086/62b4ffe300006117 GO:0005125 cytokine activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62b4ffe300006086 Activation of IL1B following cleavage by S.pyogenes speB, leading to inflammatory response (Human) NCBITaxon:9606 gomodel:62b4ffe300006086/62b4ffe300006124 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:P10220 UL36 HHV11 62b4ffe300006258 HHV1-UL36 inhibition of host cGAS-STING pathway via STING (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006258/62b4ffe300006281 GO:0101005 deubiquitinase activity GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 62b4ffe300006258 HHV1-UL36 inhibition of host cGAS-STING pathway via STING (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006258/62b4ffe300006315 GO:0061507 2',3'-cyclic GMP-AMP binding GO:0002221 pattern recognition receptor signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 62b4ffe300006258 HHV1-UL36 inhibition of host cGAS-STING pathway via STING (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006258/62b4ffe300006327 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0002221 pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P10221 UL37 HHV11 62b4ffe300006335 HHV1-UL37 inhibition of host cGAS-STING pathway via cGAS deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006335/62b4ffe300006336 GO:0050568 protein-glutamine glutaminase activity GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q8N884 CGAS Hsap 62b4ffe300006335 HHV1-UL37 inhibition of host cGAS-STING pathway via cGAS deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006335/62b4ffe300006358 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 62b4ffe300006335 HHV1-UL37 inhibition of host cGAS-STING pathway via cGAS deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006335/62b4ffe300006366 GO:0061507 2',3'-cyclic GMP-AMP binding GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:P10221 UL37 HHV11 62b4ffe300006376 HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006376/62b4ffe300006377 GO:0050568 protein-glutamine glutaminase activity GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:O95786 RIGI Hsap 62b4ffe300006376 HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006376/62b4ffe300006389 GO:0038187 pattern recognition receptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14258 TRIM25 Hsap 62b4ffe300006376 HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006376/62b4ffe300006396 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 62b4ffe300006376 HHV1-UL37 inhibition of host RIG-I signaling via RIG-I deamidation (Human-Herpesvirus) NCBITaxon:9606 gomodel:62b4ffe300006376/62b4ffe300006410 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0031966 mitochondrial membrane false UniProtKB:Q9BSA9 TMEM175 Hsap 62d0afa500001250 Regulation of lysosomal lumen pH by protein influx (V-ATPase) and proton efflux (TMEM175 and SLC7A11) (Human) NCBITaxon:9606 gomodel:62d0afa500001250/62d0afa500001251 GO:0050544 arachidonate binding GO:0035752 lysosomal lumen pH elevation GO:0005765 lysosomal membrane false UniProtKB:Q9BSA9 TMEM175 Hsap 62d0afa500001250 Regulation of lysosomal lumen pH by protein influx (V-ATPase) and proton efflux (TMEM175 and SLC7A11) (Human) NCBITaxon:9606 gomodel:62d0afa500001250/62d0afa500001258 GO:0015252 proton channel activity GO:1902600 proton transmembrane transport GO:0005765 lysosomal membrane false UniProtKB:P38606 ATP6V1A Hsap 62d0afa500001250 Regulation of lysosomal lumen pH by protein influx (V-ATPase) and proton efflux (TMEM175 and SLC7A11) (Human) NCBITaxon:9606 gomodel:62d0afa500001250/62d0afa500001290 GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:1902600 proton transmembrane transport GO:0005765 lysosomal membrane false UniProtKB:Q9UPY5 SLC7A11 Hsap 62d0afa500001250 Regulation of lysosomal lumen pH by protein influx (V-ATPase) and proton efflux (TMEM175 and SLC7A11) (Human) NCBITaxon:9606 gomodel:62d0afa500001250/680ad14200007638 GO:0022840 leak channel activity GO:1902600 proton transmembrane transport GO:0005765 lysosomal membrane false UniProtKB:Q9NY93 DDX56 Hsap 62e3212700001602 FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) NCBITaxon:9606 gomodel:62e3212700001602/62e3212700001603 GO:0140311 protein sequestering activity GO:0032480 negative regulation of type I interferon production GO:0005634 nucleus false UniProtKB:P03306-PRO_0000310975 P03306-P3A NCBITaxon:12112 62e3212700001602 FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) NCBITaxon:9606 gomodel:62e3212700001602/62e3212700001612 GO:0030674 protein-macromolecule adaptor activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0042025 host cell nucleus false UniProtKB:Q9UHD2 TBK1 Hsap 62e3212700001602 FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) NCBITaxon:9606 gomodel:62e3212700001602/62e3212700001622 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O00410 IPO5 Hsap 62e3212700001602 FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) NCBITaxon:9606 gomodel:62e3212700001602/62e3212700001632 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus GO:0031965 nuclear membrane false UniProtKB:Q14653 IRF3 Hsap 62e3212700001602 FMDV-3A inhibition of host IRF3 via DDX56 (Human-Aphthovirus) NCBITaxon:9606 gomodel:62e3212700001602/62e3212700001645 GO:0003700 DNA-binding transcription factor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0000785 chromatin false UniProtKB:O76082 SLC22A5 Hsap 62e3212700001653 Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) NCBITaxon:9606 gomodel:62e3212700001653/62e3212700001654 GO:0022857 transmembrane transporter activity GO:0070715 sodium-dependent organic cation transport GO:0016324 apical plasma membrane true carnitine_shuttle UniProtKB:P04792 HSPB1 Hsap 62e3212700001653 Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) NCBITaxon:9606 gomodel:62e3212700001653/62e3212700001675 GO:0044183 protein folding chaperone GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:P16396 epr BACSU 62e3212700001653 Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) NCBITaxon:9606 gomodel:62e3212700001653/62f58d8800001043 GO:0008236 serine-type peptidase activity GO:0140448 signaling receptor ligand precursor processing GO:0009274 peptidoglycan-based cell wall false UniProtKB:P04189 aprE BACSU 62e3212700001653 Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) NCBITaxon:9606 gomodel:62e3212700001653/62f58d8800001054 GO:0008236 serine-type peptidase activity GO:0140448 signaling receptor ligand precursor processing GO:0009274 peptidoglycan-based cell wall false UniProtKB:P29141 vpr BACSU 62e3212700001653 Gut microbiota Quorum-Sensing CSF: Regulation of intestinal homeostasis via SLC22A5/OCTN2 (Human-Bacillus subtilis) NCBITaxon:9606 gomodel:62e3212700001653/62f58d8800001073 GO:0008236 serine-type peptidase activity GO:0140448 signaling receptor ligand precursor processing GO:0009274 peptidoglycan-based cell wall false UniProtKB:Q92793 CREBBP Hsap 62e3212700001890 Regulation of energy homeostasis by OTUD3 (Human) NCBITaxon:9606 gomodel:62e3212700001890/62e3212700001897 GO:0061733 protein-lysine-acetyltransferase activity GO:0031669 cellular response to nutrient levels GO:0005737 cytoplasm false UniProtKB:Q92793 CREBBP Hsap 62e3212700001890 Regulation of energy homeostasis by OTUD3 (Human) NCBITaxon:9606 gomodel:62e3212700001890/62e3212700001910 GO:0061733 protein-lysine-acetyltransferase activity GO:1900182 positive regulation of protein localization to nucleus GO:0005737 cytoplasm false UniProtKB:Q5T2D3 OTUD3 Hsap 62e3212700001890 Regulation of energy homeostasis by OTUD3 (Human) NCBITaxon:9606 gomodel:62e3212700001890/62e3212700001926 GO:0004843 cysteine-type deubiquitinase activity GO:0071108 protein K48-linked deubiquitination GO:0005634 nucleus false UniProtKB:Q03181 PPARD Hsap 62e3212700001890 Regulation of energy homeostasis by OTUD3 (Human) NCBITaxon:9606 gomodel:62e3212700001890/62e3212700001940 GO:0003700 DNA-binding transcription factor activity GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700001957 GO:0004709 MAP kinase kinase kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700001970 GO:0004706 JUN kinase kinase kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700001982 GO:0004674 protein serine/threonine kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700001993 GO:0004674 protein serine/threonine kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:Q9C000 NLRP1 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002006 GO:0035591 signaling adaptor activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002015 GO:0140608 cysteine-type endopeptidase activator activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q15759 MAPK11 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002027 GO:0004674 protein serine/threonine kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:Q16539 MAPK14 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002038 GO:0004674 protein serine/threonine kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:P29466 CASP1 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002057 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002067 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002077 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0016020 membrane false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002085 GO:0170011 stalled ribosome sensor activity GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:P52564 MAP2K6 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002090 GO:0004708 MAP kinase kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:P46734 MAP2K3 Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/62e3212700002107 GO:0004708 MAP kinase kinase activity GO:0031098 stress-activated protein kinase signaling cascade GO:0005737 cytoplasm false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62e3212700001956 Activation of the NLRP1 inflammasome by isoform ZAKalpha of MAP3K20 in response to UV-B irradiation and ribotoxic stress (Human) NCBITaxon:9606 gomodel:62e3212700001956/635b1e3e00001516 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62f58d8800000011 Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human) NCBITaxon:9606 gomodel:62f58d8800000011/62f58d8800000012 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P29466 CASP1 Hsap 62f58d8800000011 Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human) NCBITaxon:9606 gomodel:62f58d8800000011/62f58d8800000019 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62f58d8800000011 Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human) NCBITaxon:9606 gomodel:62f58d8800000011/635b1e3e00001506 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:Q66478-PRO_0000426148 Q66478-Protease_3C NCBITaxon:69153 62f58d8800000011 Inactivation of GSDMD by Protease 3C from Human enterovirus 71 (EV71) (Human) NCBITaxon:9606 gomodel:62f58d8800000011/68fac5ed00004252 GO:0004197 cysteine-type endopeptidase activity GO:0052041 symbiont-mediated suppression of host programmed cell death false UniProtKB:Q9P2K8 EIF2AK4 Hsap 62f58d8800000037 Activation of the kinase activity of EIF2AK4/GCN2 by isoform ZAKalpha of MAP3K20 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:62f58d8800000037/62f58d8800000047 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140469 GCN2-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 62f58d8800000037 Activation of the kinase activity of EIF2AK4/GCN2 by isoform ZAKalpha of MAP3K20 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:62f58d8800000037/62f58d8800000057 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NYL2-1 MAP3K20 Hsap 62f58d8800000037 Activation of the kinase activity of EIF2AK4/GCN2 by isoform ZAKalpha of MAP3K20 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:62f58d8800000037/63d320cd00001794 GO:0170011 stalled ribosome sensor activity GO:1902010 negative regulation of translation in response to endoplasmic reticulum stress GO:0005737 cytoplasm false UniProtKB:Q16531 DDB1 Hsap 62f58d8800000464 HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800000464/62f58d8800000465 GO:0097602 cullin family protein binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:F5HF44 UL145 HCMVM 62f58d8800000464 HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800000464/62f58d8800000469 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity GO:0042025 host cell nucleus false UniProtKB:Q13619 CUL4A Hsap 62f58d8800000464 HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800000464/62f58d8800000868 GO:0031625 ubiquitin protein ligase binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:P52630 STAT2 Hsap 62f58d8800000464 HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800000464/62f58d8800000913 GO:0003700 DNA-binding transcription factor activity GO:0060337 type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 62f58d8800000464 HCMV-UL145 inhibition of STAT2 via DDB1/CUL4A (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800000464/636d9ce800001377 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:P69726 vpr NCBITaxon:11706 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/62f58d8800000938 GO:0060090 molecular adaptor activity GO:0045738 negative regulation of DNA repair GO:0042025 host cell nucleus false UniProtKB:P13051 UNG Hsap 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/62f58d8800000965 GO:0004844 uracil DNA N-glycosylase activity GO:0097510 base-excision repair, AP site formation via deaminated base removal GO:0005634 nucleus false UniProtKB:Q9Y4B6 DCAF1 Hsap 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/62f58d8800000972 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:Q16531 DDB1 Hsap 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/62f58d8800000985 GO:0097602 cullin family protein binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:Q13619 CUL4A Hsap 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/62f58d8800001008 GO:0031625 ubiquitin protein ligase binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 62f58d8800000934 HIV1-Vpr inhibition of UNG2 via DDB1/CUL4A (Human-Lentivrus) NCBITaxon:9606 gomodel:62f58d8800000934/636d9ce800001391 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:Q16531 DDB1 Hsap 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/62f58d8800001023 GO:0097602 cullin family protein binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/62f58d8800001031 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:Q69027 X HBVCJ 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/62f58d8800001066 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0039693 viral DNA genome replication GO:0042025 host cell nucleus false UniProtKB:Q8IY18 SMC5 Hsap 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/62f58d8800001104 GO:0000217 DNA secondary structure binding GO:0044828 host-mediated suppression of viral genome replication GO:0005634 nucleus false UniProtKB:Q96SB8 SMC6 Hsap 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/62f58d8800001111 GO:0000217 DNA secondary structure binding GO:0044828 host-mediated suppression of viral genome replication GO:0005634 nucleus false UniProtKB:Q13619 CUL4A Hsap 62f58d8800001022 HBV-HBX inhibition of Smad5/6 via DDB1/CUL4A (Human-Hepadnavirus) NCBITaxon:9606 gomodel:62f58d8800001022/636d9ce800001404 GO:0031625 ubiquitin protein ligase binding GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false UniProtKB:Q16531 DDB1 Hsap 62f58d8800001316 PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001316/62f58d8800001317 GO:0097602 cullin family protein binding GO:0045732 positive regulation of protein catabolic process false UniProtKB:P62877 RBX1 Hsap 62f58d8800001316 PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001316/62f58d8800001320 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process false UniProtKB:P11207 P/V NCBITaxon:11208 62f58d8800001316 PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001316/62f58d8800001343 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity false UniProtKB:P42224 STAT1 Hsap 62f58d8800001316 PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001316/62f58d8800001353 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0060337 type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:Q13619 CUL4A Hsap 62f58d8800001316 PIV5-V inhibition of STAT1 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001316/636d9ce800001434 GO:0031625 ubiquitin protein ligase binding GO:0045732 positive regulation of protein catabolic process false UniProtKB:Q16531 DDB1 Hsap 62f58d8800001368 Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001368/62f58d8800001369 GO:0097602 cullin family protein binding GO:0045732 positive regulation of protein catabolic process false UniProtKB:Q13619 CUL4A Hsap 62f58d8800001368 Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001368/62f58d8800001372 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process false UniProtKB:P33483 P/V/I NCBITaxon:33729 62f58d8800001368 Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001368/62f58d8800001377 GO:0060090 molecular adaptor activity GO:0039564 symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity false UniProtKB:P40763 STAT3 Hsap 62f58d8800001368 Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001368/62f58d8800001382 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0019221 cytokine-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 62f58d8800001368 Mumps-V inhibition of STAT3 via DDB1/CUL4A (Human-Paramyxovirus) NCBITaxon:9606 gomodel:62f58d8800001368/636d9ce800001413 GO:0061630 ubiquitin protein ligase activity GO:0045732 positive regulation of protein catabolic process GO:0005634 nucleus false EcoCyc:TRYPTOPHAN-MONOMER TnaA Ecol 62f58d8800001680 Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001680/62f58d8800001681 GO:0009034 tryptophanase activity GO:0042431 indole metabolic process false UniProtKB:P35869 AHR Hsap 62f58d8800001680 Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001680/62f58d8800001696 GO:0004879 nuclear receptor activity GO:0071219 cellular response to molecule of bacterial origin GO:0005634 nucleus false UniProtKB:P27540 ARNT Hsap 62f58d8800001680 Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001680/62f58d8800001706 GO:0003700 DNA-binding transcription factor activity GO:0050728 negative regulation of inflammatory response GO:0005634 nucleus false UniProtKB:Q13651 IL10RA Hsap 62f58d8800001680 Gut Microbiota tryptophan metabolism: Regulation of intestinal epithelial cell homesotasis by Indole-AhR (Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001680/62f58d8800001721 GO:0004920 interleukin-10 receptor activity GO:0140105 interleukin-10-mediated signaling pathway GO:0016324 apical plasma membrane false EcoCyc:TRYPTOPHAN-MONOMER TnaA Ecol 62f58d8800001738 Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001738/62f58d8800001739 GO:0009034 tryptophanase activity GO:0042431 indole metabolic process false GO:1990454 L-type voltage-gated calcium channel complex 62f58d8800001738 Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001738/62f58d8800001778 GO:0005262 calcium channel activity GO:1902656 calcium ion import into cytosol GO:0005886 plasma membrane false UniProtKB:P20711 DDC Hsap 62f58d8800001738 Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001738/62f58d8800001792 GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity GO:0042427 serotonin biosynthetic process GO:0005737 cytoplasm false UniProtKB:Q13639 HTR4 Hsap 62f58d8800001738 Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001738/62f58d8800001808 GO:0099589 serotonin receptor activity GO:0120056 large intestinal transit GO:0005886 plasma membrane false UniProtKB:P17752 TPH1 Hsap 62f58d8800001738 Gut Microbiota tryptophan metabolism: Regulation of intestinal transit by 5-hydroxy-L-tryptophan(Human-E.coli) NCBITaxon:9606 gomodel:62f58d8800001738/62f58d8800001819 GO:0004510 tryptophan 5-monooxygenase activity GO:0042427 serotonin biosynthetic process GO:0005829 cytosol false UniProtKB:P28328 PEX2 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002499 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination GO:0005778 peroxisomal membrane false UniProtKB:P50542 PEX5 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002513 GO:0140597 protein carrier activity GO:0016558 protein import into peroxisome matrix GO:0005782 peroxisomal matrix false UniProtKB:P50542 PEX5 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002523 GO:0000268 peroxisome signal sequence receptor activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:P50542 PEX5 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002527 GO:0140597 protein carrier activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:O75381 PEX14 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002535 GO:0030674 protein-macromolecule adaptor activity GO:0016560 protein import into peroxisome matrix, docking GO:0005778 peroxisomal membrane false UniProtKB:O75381 PEX14 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002572 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:Q92968 PEX13 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002581 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:O60683 PEX10 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002601 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:P28328 PEX2 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002612 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:O00623 PEX12 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002623 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:O43933 PEX1 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002648 GO:0140567 membrane protein dislocase activity GO:0043335 protein unfolding GO:0005777 peroxisome false UniProtKB:Q13608 PEX6 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002657 GO:0140567 membrane protein dislocase activity GO:0043335 protein unfolding GO:0005777 peroxisome false UniProtKB:Q93008 USP9X Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002697 GO:0004843 cysteine-type deubiquitinase activity GO:0035520 monoubiquitinated protein deubiquitination GO:0005829 cytosol false UniProtKB:O43933 PEX1 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002707 GO:0140036 ubiquitin-modified protein reader activity GO:0016562 protein import into peroxisome matrix, receptor recycling GO:0005777 peroxisome false UniProtKB:Q13608 PEX6 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002720 GO:0140036 ubiquitin-modified protein reader activity GO:0016562 protein import into peroxisome matrix, receptor recycling GO:0005777 peroxisome false UniProtKB:O94972 TRIM37 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800002979 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination GO:0005778 peroxisomal membrane false UniProtKB:Q7Z412 PEX26 Hsap 62f58d8800002485 Protein import into peroxisomes of PTS1-containing proteins by the PEX5 receptor, and recycling of the PEX5 receptor (Human) NCBITaxon:9606 gomodel:62f58d8800002485/62f58d8800004910 GO:0043495 protein-membrane adaptor activity GO:0022615 protein to membrane docking GO:0005778 peroxisomal membrane false UniProtKB:P28328 PEX2 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003278 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination GO:0005778 peroxisomal membrane false UniProtKB:P50542 PEX5 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003285 GO:0140597 protein carrier activity GO:0016558 protein import into peroxisome matrix GO:0005782 peroxisomal matrix false UniProtKB:P50542 PEX5 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003289 GO:0000268 peroxisome signal sequence receptor activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:P50542 PEX5 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003293 GO:0140597 protein carrier activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:O75381 PEX14 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003297 GO:0030674 protein-macromolecule adaptor activity GO:0016560 protein import into peroxisome matrix, docking GO:0005778 peroxisomal membrane false UniProtKB:O75381 PEX14 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003302 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:Q92968 PEX13 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003307 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:O60683 PEX10 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003312 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:P28328 PEX2 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003318 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:O00623 PEX12 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003324 GO:0008320 transmembrane protein transporter activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005778 peroxisomal membrane false UniProtKB:Q13315 ATM Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003400 GO:0004674 protein serine/threonine kinase activity GO:0034614 cellular response to reactive oxygen species GO:0005782 peroxisomal matrix false UniProtKB:P50542 PEX5 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003452 GO:0140597 protein carrier activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005782 peroxisomal matrix false UniProtKB:Q13501 SQSTM1 Hsap 62f58d8800003277 Import of ATM into peroxisomes y in response to reactive oxygen species via the PEX5-dependent import pathway, leading to PEX5 ubiquitination and pexophagy (Human) NCBITaxon:9606 gomodel:62f58d8800003277/62f58d8800003485 GO:0030674 protein-macromolecule adaptor activity GO:0000425 pexophagy GO:0005829 cytosol false UniProtKB:P50542-1 PEX5 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003544 GO:0140597 protein carrier activity GO:0044721 protein import into peroxisome matrix, substrate release GO:0005782 peroxisomal matrix false UniProtKB:O00628 PEX7 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003548 GO:0000268 peroxisome signal sequence receptor activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:P50542-1 PEX5 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003552 GO:0140597 protein carrier activity GO:0016558 protein import into peroxisome matrix GO:0005829 cytosol false UniProtKB:O75381 PEX14 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003556 GO:0030674 protein-macromolecule adaptor activity GO:0016560 protein import into peroxisome matrix, docking GO:0005778 peroxisomal membrane false UniProtKB:O75381 PEX14 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003561 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:Q92968 PEX13 Hsap 62f58d8800003536 Protein import into peroxisomes of PTS2-containing proteins by the PEX7 receptor and isoform PEX5L of PEX5 (Human) NCBITaxon:9606 gomodel:62f58d8800003536/62f58d8800003566 GO:0008320 transmembrane protein transporter activity GO:0016561 protein import into peroxisome matrix, translocation GO:0005778 peroxisomal membrane false UniProtKB:Q9UIJ5 ZDHHC2 Hsap 62f58d8800004747 ZDHHC2 in regulation of long-term synaptic potentiation via AKAP5 (Human) NCBITaxon:9606 gomodel:62f58d8800004747/62f58d8800004748 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:1903044 protein localization to membrane raft GO:0098837 postsynaptic recycling endosome false UniProtKB:P24588 AKAP5 Hsap 62f58d8800004747 ZDHHC2 in regulation of long-term synaptic potentiation via AKAP5 (Human) NCBITaxon:9606 gomodel:62f58d8800004747/62f58d8800004751 GO:0060090 molecular adaptor activity GO:0099630 postsynaptic neurotransmitter receptor cycle GO:0098837 postsynaptic recycling endosome false UniProtKB:P42261 GRIA1 Hsap 62f58d8800004747 ZDHHC2 in regulation of long-term synaptic potentiation via AKAP5 (Human) NCBITaxon:9606 gomodel:62f58d8800004747/62f58d8800004755 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:0007416 synapse assembly GO:0032591 dendritic spine membrane false UniProtKB:O43164 PJA2 Hsap 62f58d8800004946 TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) NCBITaxon:9606 gomodel:62f58d8800004946/62f58d8800004947 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0036064 ciliary basal body false UniProtKB:O75665 OFD1 Hsap 62f58d8800004946 TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) NCBITaxon:9606 gomodel:62f58d8800004946/62f58d8800004949 GO:0060090 molecular adaptor activity GO:0060271 cilium assembly GO:0036064 ciliary basal body false UniProtKB:Q96DN5 TBC1D31 Hsap 62f58d8800004946 TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) NCBITaxon:9606 gomodel:62f58d8800004946/62f58d8800004952 GO:0060090 molecular adaptor activity GO:0060271 cilium assembly GO:0036064 ciliary basal body false UniProtKB:P17252 PRKCA Hsap 62f58d8800004946 TBC1D31/PJA2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation (Human) NCBITaxon:9606 gomodel:62f58d8800004946/62f58d8800004956 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0036064 ciliary basal body false UniProtKB:O95568 METTL18 Hsap 62f58d8800005377 Histidine methylation of RPL3 by METTL18 that regulates translation elongation (Human) NCBITaxon:9606 gomodel:62f58d8800005377/62f58d8800005378 GO:0018064 protein-L-histidine N-tele-methyltransferase activity GO:0006448 regulation of translational elongation GO:0005829 cytosol false UniProtKB:P39023 RPL3 Hsap 62f58d8800005377 Histidine methylation of RPL3 by METTL18 that regulates translation elongation (Human) NCBITaxon:9606 gomodel:62f58d8800005377/62f58d8800005389 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:O95568 METTL18 Hsap 62f58d8800005377 Histidine methylation of RPL3 by METTL18 that regulates translation elongation (Human) NCBITaxon:9606 gomodel:62f58d8800005377/62f58d8800005395 GO:0018064 protein-L-histidine N-tele-methyltransferase activity GO:0006448 regulation of translational elongation GO:0005829 cytosol false UniProtKB:Q9BQB6 VKORC1 Hsap 62f58d8800005413 Inhibition of vitamin K metabolic process via inhibition of VKORC1 by warfarin; antidotal effect of AIFM2/FSP1 that suppresses ferroptosis (Human) NCBITaxon:9606 gomodel:62f58d8800005413/62f58d8800005414 GO:0047058 vitamin-K-epoxide reductase (warfarin-insensitive) activity GO:0042373 vitamin K metabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:P38435 GGCX Hsap 62f58d8800005413 Inhibition of vitamin K metabolic process via inhibition of VKORC1 by warfarin; antidotal effect of AIFM2/FSP1 that suppresses ferroptosis (Human) NCBITaxon:9606 gomodel:62f58d8800005413/62f58d8800005425 GO:0008488 gamma-glutamyl carboxylase activity GO:0042373 vitamin K metabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9BRQ8 AIFM2 Hsap 62f58d8800005413 Inhibition of vitamin K metabolic process via inhibition of VKORC1 by warfarin; antidotal effect of AIFM2/FSP1 that suppresses ferroptosis (Human) NCBITaxon:9606 gomodel:62f58d8800005413/62f58d8800005434 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:1990748 cellular detoxification GO:0005811 lipid droplet false UniProtKB:Q9BQB6 VKORC1 Hsap 62f58d8800005413 Inhibition of vitamin K metabolic process via inhibition of VKORC1 by warfarin; antidotal effect of AIFM2/FSP1 that suppresses ferroptosis (Human) NCBITaxon:9606 gomodel:62f58d8800005413/62f58d8800005451 GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity GO:0042373 vitamin K metabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:O15533 TAPBP Hsap 62f58d8800005854 HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005854/62f58d8800005855 GO:0060090 molecular adaptor activity GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03518 TAP1 Hsap 62f58d8800005854 HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005854/62f58d8800005862 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03519 TAP2 Hsap 62f58d8800005854 HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005854/62f58d8800005869 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:P03170 US12 HHV11 62f58d8800005854 HHV1-ICP47 inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005854/62f58d8800005891 GO:0140313 molecular sequestering activity GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:O15533 TAPBP Hsap 62f58d8800005908 HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005908/62f58d8800005909 GO:0060090 molecular adaptor activity GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03518 TAP1 Hsap 62f58d8800005908 HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005908/62f58d8800005913 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03519 TAP2 Hsap 62f58d8800005908 HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005908/62f58d8800005917 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03518 TAP1 Hsap 62f58d8800005908 HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005908/62f58d8800005949 GO:0005524 ATP binding GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:P14334 US6 HCMVA 62f58d8800005908 HCMV-US6 inhibition of MHC class I peptide antigen assembly via inhibition of TAP1 ATP-binding (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800005908/62f58d8800005959 GO:0140313 molecular sequestering activity GO:0046776 symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I GO:0044167 host cell endoplasmic reticulum membrane false UniProtKB:O15533 TAPBP Hsap 62f58d8800006008 EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800006008/62f58d8800006009 GO:0060090 molecular adaptor activity GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03518 TAP1 Hsap 62f58d8800006008 EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800006008/62f58d8800006013 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03519 TAP2 Hsap 62f58d8800006008 EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800006008/62f58d8800006017 GO:0015433 ABC-type peptide antigen transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:O43681 GET3 Hsap 62f58d8800006008 EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800006008/632cf60a00000146 GO:0140597 protein carrier activity GO:0071816 tail-anchored membrane protein insertion into ER membrane GO:0005789 endoplasmic reticulum membrane false UniProtKB:P0C739 BNLF2a NCBITaxon:10377 62f58d8800006008 EBV-BNLF2a inhibition of MHC class I peptide antigen assembly via TAP1/TAP2 (Human-Herpesvirus) NCBITaxon:9606 gomodel:62f58d8800006008/632cf60a00000155 GO:0140311 protein sequestering activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:C8WMP0 Elen_0690 NCBITaxon:479437 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/62f58d8800006249 GO:0047043 3-alpha-hydroxycholanate dehydrogenase activity GO:0008206 bile acid metabolic process false UniProtKB:C8WGQ3 Elen_1325 NCBITaxon:479437 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/62f58d8800006258 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0008206 bile acid metabolic process false UniProtKB:A7B3K3 baiA NCBITaxon:411470 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/62f58d8800006272 GO:0047043 3-alpha-hydroxycholanate dehydrogenase activity GO:0008206 bile acid metabolic process false UniProtKB:A7AZH2 RUMGNA_00694 NCBITaxon:411470 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/62f58d8800006279 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0008206 bile acid metabolic process false UniProtKB:P51449-2 RORC Hsap 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/62f58d8800006295 GO:0004879 nuclear receptor activity GO:0072539 T-helper 17 cell differentiation GO:0005634 nucleus false UniProtKB:Q9BZS1 FOXP3 Hsap 62f58d8800006248 Gut Microbiota bile acid metabolism: Inhibition of Th17 differentiation by 3-oxoLCA and isoLCA. (Human-R.gnavus/E.lenta) NCBITaxon:9606 gomodel:62f58d8800006248/633b013300001095 GO:0003712 transcription coregulator activity GO:0000302 response to reactive oxygen species GO:0005634 nucleus false UniProtKB:P0DTD1-PRO_0000449623 nsp5 Scov2 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006930 GO:0004197 cysteine-type endopeptidase activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0030430 host cell cytoplasm false UniProtKB:P0DTD1-PRO_0000449623 nsp5 Scov2 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006941 GO:0004197 cysteine-type endopeptidase activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0030430 host cell cytoplasm false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006950 GO:0140693 molecular condensate scaffold activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006958 GO:0140608 cysteine-type endopeptidase activator activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006967 GO:0140608 cysteine-type endopeptidase activator activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006978 GO:0035591 signaling adaptor activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006989 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800006999 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800007010 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:Q14790 CASP8 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800007022 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P42574 CASP3 Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800007035 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:O60443-PRO_0000442786 GSDME-GSDME-NT Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/62f58d8800007053 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 62f58d8800006929 Cleavage of NLRP1cand GSDMD by SARS-CoV-2 protease Nsp5, leading to inhibition of GSDMD-mediated pyroptosis and concomitant initiation of GSDME-mediated pyroptosis in lung epithelial cells (Human and SARS-CoV-2) NCBITaxon:9606 gomodel:62f58d8800006929/635b1e3e00001497 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800007064 Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) NCBITaxon:9606 gomodel:62f58d8800007064/62f58d8800007076 GO:0140693 molecular condensate scaffold activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q9C000 NLRP1 Hsap 62f58d8800007064 Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) NCBITaxon:9606 gomodel:62f58d8800007064/62f58d8800007085 GO:0140608 cysteine-type endopeptidase activator activity GO:1904784 NLRP1 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q14790 CASP8 Hsap 62f58d8800007064 Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) NCBITaxon:9606 gomodel:62f58d8800007064/62f58d8800007110 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P42574 CASP3 Hsap 62f58d8800007064 Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) NCBITaxon:9606 gomodel:62f58d8800007064/62f58d8800007115 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:O60443-PRO_0000442786 GSDME-GSDME-NT Hsap 62f58d8800007064 Activation of GSDME--mediated pyroptosis by NLRP1 in absence of GSDMD (Human) NCBITaxon:9606 gomodel:62f58d8800007064/62f58d8800007121 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:A0AV96 RBM47 Hsap 632cf60a00000028 mRNA editing enabled by APOBEC1 (Human) NCBITaxon:9606 gomodel:632cf60a00000028/632cf60a00000029 GO:0140767 enzyme-substrate adaptor activity GO:0016554 cytidine to uridine editing GO:0005634 nucleus false UniProtKB:P41238 APOBEC1 Hsap 632cf60a00000028 mRNA editing enabled by APOBEC1 (Human) NCBITaxon:9606 gomodel:632cf60a00000028/632cf60a00000032 GO:0004126 cytidine deaminase activity GO:0016554 cytidine to uridine editing GO:0005634 nucleus false UniProtKB:Q9NQ94 A1CF Hsap 632cf60a00000028 mRNA editing enabled by APOBEC1 (Human) NCBITaxon:9606 gomodel:632cf60a00000028/632cf60a00000760 GO:0140767 enzyme-substrate adaptor activity GO:0016554 cytidine to uridine editing GO:0005634 nucleus false UniProtKB:P04114 APOB Hsap 632cf60a00000028 mRNA editing enabled by APOBEC1 (Human) NCBITaxon:9606 gomodel:632cf60a00000028/632cf60a00000776 GO:0050750 low-density lipoprotein particle receptor binding GO:0034383 low-density lipoprotein particle clearance false UniProtKB:Q14149 MORC3 Hsap 632cf60a00000169 HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000169/632cf60a00000170 GO:0030674 protein-macromolecule adaptor activity GO:0140374 antiviral innate immune response GO:0016605 PML body false UniProtKB:Q14149 MORC3 Hsap 632cf60a00000169 HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000169/632cf60a00000181 GO:0003677 DNA binding GO:0000122 negative regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:P08393 ICP0 HHV11 632cf60a00000169 HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000169/632cf60a00000188 GO:0061630 ubiquitin protein ligase activity GO:0039502 symbiont-mediated suppression of host type I interferon-mediated signaling pathway GO:0042025 host cell nucleus false UniProtKB:P01574 IFNB1 Hsap 632cf60a00000169 HHV1-ICP0 modulation of interferon production via MORC3 degradation (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000169/632cf60a00000200 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q9UHD2 TBK1 Hsap 632cf60a00000478 HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000478/632cf60a00000479 GO:0004674 protein serine/threonine kinase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:P36406 TRIM23 Hsap 632cf60a00000478 HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000478/632cf60a00000486 GO:0061630 ubiquitin protein ligase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:Q13501 SQSTM1 Hsap 632cf60a00000478 HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000478/632cf60a00000496 GO:0038023 signaling receptor activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:P04487 US11 HHV11 632cf60a00000478 HHV1-US11 inhibition of autophagy via TRIM23-TBK1 (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000478/632cf60a00000512 GO:0140313 molecular sequestering activity GO:0140321 symbiont-mediated suppression of host autophagy GO:0030430 host cell cytoplasm false UniProtKB:Q14790 CASP8 Hsap 632cf60a00000522 HHV1-US11 inhibition of autophagy via CASP8 cleavage (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000522/632cf60a00000523 GO:0004197 cysteine-type endopeptidase activity GO:0097191 extrinsic apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:P04487 US11 HHV11 632cf60a00000522 HHV1-US11 inhibition of autophagy via CASP8 cleavage (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000522/632cf60a00000530 GO:0004175 endopeptidase activity GO:0140321 symbiont-mediated suppression of host autophagy GO:0030430 host cell cytoplasm false UniProtKB:Q9NT62 ATG3 Hsap 632cf60a00000522 HHV1-US11 inhibition of autophagy via CASP8 cleavage (Human-Herpesvirus) NCBITaxon:9606 gomodel:632cf60a00000522/632cf60a00000565 GO:0019777 Atg12 transferase activity GO:0000045 autophagosome assembly GO:0005737 cytoplasm false UniProtKB:Q9UMW8 USP18 Hsap 632cf60a00000788 USP20-mediated STING deubiquitination leading to STING stabilisation (Human) NCBITaxon:9606 gomodel:632cf60a00000788/632cf60a00000790 GO:0060090 molecular adaptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9Y2K6 USP20 Hsap 632cf60a00000788 USP20-mediated STING deubiquitination leading to STING stabilisation (Human) NCBITaxon:9606 gomodel:632cf60a00000788/632cf60a00000801 GO:0004843 cysteine-type deubiquitinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 632cf60a00000788 USP20-mediated STING deubiquitination leading to STING stabilisation (Human) NCBITaxon:9606 gomodel:632cf60a00000788/632cf60a00000811 GO:0061507 2',3'-cyclic GMP-AMP binding GO:0140374 antiviral innate immune response GO:0005789 endoplasmic reticulum membrane false UniProtKB:O43914 TYROBP Hsap 633b013300001197 TRIM27-mediated ubiquitination and degradation of TBK1 (Human) NCBITaxon:9606 gomodel:633b013300001197/633b013300001198 GO:0060090 molecular adaptor activity GO:0032480 negative regulation of type I interferon production GO:0005886 plasma membrane false UniProtKB:Q06124 PTPN11 Hsap 633b013300001197 TRIM27-mediated ubiquitination and degradation of TBK1 (Human) NCBITaxon:9606 gomodel:633b013300001197/633b013300001207 GO:0060090 molecular adaptor activity GO:0032480 negative regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:P14373 TRIM27 Hsap 633b013300001197 TRIM27-mediated ubiquitination and degradation of TBK1 (Human) NCBITaxon:9606 gomodel:633b013300001197/633b013300001217 GO:0061630 ubiquitin protein ligase activity GO:0032480 negative regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 633b013300001197 TRIM27-mediated ubiquitination and degradation of TBK1 (Human) NCBITaxon:9606 gomodel:633b013300001197/633b013300001227 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q9BZZ2 SIGLEC1 Hsap 633b013300001197 TRIM27-mediated ubiquitination and degradation of TBK1 (Human) NCBITaxon:9606 gomodel:633b013300001197/648d0dc100000003 GO:0046790 virion binding GO:0032480 negative regulation of type I interferon production GO:0005886 plasma membrane false UniProtKB:P14373 TRIM27 Hsap 633b013300001722 TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human) NCBITaxon:9606 gomodel:633b013300001722/633b013300001723 GO:0061630 ubiquitin protein ligase activity GO:0010507 negative regulation of autophagy GO:0005737 cytoplasm false UniProtKB:Q9Y2H1 STK38L Hsap 633b013300001722 TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human) NCBITaxon:9606 gomodel:633b013300001722/633b013300001734 GO:0004674 protein serine/threonine kinase activity GO:0010507 negative regulation of autophagy GO:0005737 cytoplasm false UniProtKB:P14373 TRIM27 Hsap 633b013300001722 TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human) NCBITaxon:9606 gomodel:633b013300001722/633b013300001744 GO:0061630 ubiquitin protein ligase activity GO:0010507 negative regulation of autophagy GO:0005737 cytoplasm false UniProtKB:O75385 ULK1 Hsap 633b013300001722 TRIM27-mediated inhibition of starvation-induced autophagy via ubiquitination of STK38L and ULK1 (Human) NCBITaxon:9606 gomodel:633b013300001722/633b013300001754 GO:0004674 protein serine/threonine kinase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:Q9Y2K6 USP20 Hsap 6348a65d00000093 USP20 inhibition of NF-kappa-B signaling via TRAF6 deubiquitination (Human) NCBITaxon:9606 gomodel:6348a65d00000093/6348a65d00000094 GO:0004843 cysteine-type deubiquitinase activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P32121 ARRB2 Hsap 6348a65d00000093 USP20 inhibition of NF-kappa-B signaling via TRAF6 deubiquitination (Human) NCBITaxon:9606 gomodel:6348a65d00000093/6348a65d00000103 GO:0060090 molecular adaptor activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y2K6 USP20 Hsap 6348a65d00000093 USP20 inhibition of NF-kappa-B signaling via TRAF6 deubiquitination (Human) NCBITaxon:9606 gomodel:6348a65d00000093/6348a65d00000115 GO:0004843 cysteine-type deubiquitinase activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6348a65d00000093 USP20 inhibition of NF-kappa-B signaling via TRAF6 deubiquitination (Human) NCBITaxon:9606 gomodel:6348a65d00000093/6348a65d00000124 GO:0061630 ubiquitin protein ligase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y2K6 USP20 Hsap 6348a65d00000136 USP20-mediated ULK1 stabilisation for autophagy initiation (Human) NCBITaxon:9606 gomodel:6348a65d00000136/6348a65d00000137 GO:0004843 cysteine-type deubiquitinase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:O75385 ULK1 Hsap 6348a65d00000136 USP20-mediated ULK1 stabilisation for autophagy initiation (Human) NCBITaxon:9606 gomodel:6348a65d00000136/6348a65d00000146 GO:0004674 protein serine/threonine kinase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:O75143 ATG13 Hsap 6348a65d00000136 USP20-mediated ULK1 stabilisation for autophagy initiation (Human) NCBITaxon:9606 gomodel:6348a65d00000136/6348a65d00000156 GO:0019901 protein kinase binding GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:Q16552 IL17A Hsap 6348a65d00000452 Regulation by IL17 and REG3A of keratinocyte proliferation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000452/6348a65d00000453 GO:0005125 cytokine activity GO:0009611 response to wounding GO:0005576 extracellular region false UniProtKB:Q06141 REG3A Hsap 6348a65d00000452 Regulation by IL17 and REG3A of keratinocyte proliferation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000452/6348a65d00000460 GO:0005179 hormone activity GO:0010838 positive regulation of keratinocyte proliferation GO:0005576 extracellular region false UniProtKB:O43909 EXTL3 Hsap 6348a65d00000452 Regulation by IL17 and REG3A of keratinocyte proliferation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000452/6348a65d00000474 GO:0016500 protein-hormone receptor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005886 plasma membrane false UniProtKB:Q16552 IL17A Hsap 6348a65d00000486 Regulation by IL17 and REG3A of keratinocyte differentiation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000486/6348a65d00000487 GO:0005125 cytokine activity GO:0009611 response to wounding GO:0005576 extracellular region false UniProtKB:Q06141 REG3A Hsap 6348a65d00000486 Regulation by IL17 and REG3A of keratinocyte differentiation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000486/6348a65d00000491 GO:0005179 hormone activity GO:0045617 negative regulation of keratinocyte differentiation GO:0005576 extracellular region false UniProtKB:O43909 EXTL3 Hsap 6348a65d00000486 Regulation by IL17 and REG3A of keratinocyte differentiation after skin injury (Human) NCBITaxon:9606 gomodel:6348a65d00000486/6348a65d00000498 GO:0016500 protein-hormone receptor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005886 plasma membrane false UniProtKB:P12544 GZMA Hsap 6348a65d00000594 Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human) NCBITaxon:9606 gomodel:6348a65d00000594/6348a65d00000598 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P14222 PRF1 Hsap 6348a65d00000594 Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human) NCBITaxon:9606 gomodel:6348a65d00000594/6348a65d00000614 GO:0022829 wide pore channel activity GO:0071806 protein transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q8TAX9-4 GSDMB Hsap 6348a65d00000594 Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human) NCBITaxon:9606 gomodel:6348a65d00000594/6348a65d00000640 GO:0005543 phospholipid binding GO:1902483 cytotoxic T cell pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:Q8TAX9-4 GSDMB Hsap 6348a65d00000594 Granzyme-mediated (GZMA) activation of pyroptosis (GSDMB isoform 4) (Human) NCBITaxon:9606 gomodel:6348a65d00000594/6348a65d00000653 GO:0022829 wide pore channel activity GO:1902483 cytotoxic T cell pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P12544 GZMA Hsap 6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) NCBITaxon:9606 gomodel:6348a65d00000661/6348a65d00000662 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P14222 PRF1 Hsap 6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) NCBITaxon:9606 gomodel:6348a65d00000661/6348a65d00000666 GO:0022829 wide pore channel activity GO:0071806 protein transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q8TAX9-1 GSDMB Hsap 6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) NCBITaxon:9606 gomodel:6348a65d00000661/6348a65d00000675 GO:1901612 cardiolipin binding GO:1902483 cytotoxic T cell pyroptotic cell death false UniProtKB:Q8TAX9-1 GSDMB Hsap 6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) NCBITaxon:9606 gomodel:6348a65d00000661/6348a65d00000679 GO:0022829 wide pore channel activity GO:1902483 cytotoxic T cell pyroptotic cell death false UniProtKB:P18014 ipaH7.8 SHIFL 6348a65d00000661 Cytotoxic T cell pyroptosis mediated by GSDMB isoform 1 in response to infection by Gram-negative bacteria and its inhibition by S.flexneri IpaH7.8 (Human and S.flexneri) NCBITaxon:9606 gomodel:6348a65d00000661/6348a65d00000709 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0030430 host cell cytoplasm false UniProtKB:Q9GZX6 IL22 Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000849 GO:0005125 cytokine activity GO:0050728 negative regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:Q8N6P7 IL22RA1 Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000855 GO:0042018 interleukin-22 receptor activity GO:0050728 negative regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:P40763 STAT3 Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000861 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0050728 negative regulation of inflammatory response GO:0005634 nucleus false UniProtKB:Q06141 REG3A Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000867 GO:0005179 hormone activity GO:0050728 negative regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:O43909 EXTL3 Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000873 GO:0016500 protein-hormone receptor activity GO:1900016 negative regulation of cytokine production involved in inflammatory response GO:0005886 plasma membrane false UniProtKB:O95760 IL33 Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000879 GO:0005125 cytokine activity GO:0050729 positive regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:Q969D9 TSLP Hsap 6348a65d00000848 Regulation by IL22 and REG3A of allergic airway inflammation. (Human) NCBITaxon:9606 gomodel:6348a65d00000848/6348a65d00000883 GO:0005125 cytokine activity GO:0050729 positive regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:O95760 IL33 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001735 GO:0005125 cytokine activity GO:0106015 negative regulation of inflammatory response to wounding GO:0005576 extracellular region false UniProtKB:Q06141 REG3A Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001743 GO:0005179 hormone activity GO:0106015 negative regulation of inflammatory response to wounding GO:0005576 extracellular region false UniProtKB:O43909 EXTL3 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001753 GO:0016500 protein-hormone receptor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005886 plasma membrane false UniProtKB:P40763 STAT3 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001767 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005634 nucleus false UniProtKB:P29350 PTPN6 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001781 GO:0004725 protein tyrosine phosphatase activity GO:0106015 negative regulation of inflammatory response to wounding GO:0005737 cytoplasm false UniProtKB:P45984 MAPK9 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001791 GO:0004705 JUN kinase activity GO:1900017 positive regulation of cytokine production involved in inflammatory response GO:0005737 cytoplasm false UniProtKB:O15455 TLR3 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001804 GO:0004888 transmembrane signaling receptor activity GO:0046330 positive regulation of JNK cascade GO:0005886 plasma membrane false UniProtKB:P05231 IL6 Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001816 GO:0005125 cytokine activity GO:0090594 inflammatory response to wounding GO:0005576 extracellular region false UniProtKB:P01375 TNF Hsap 6348a65d00001727 Negative regulation of inflammatory response to wounding by REG3A. (Human) NCBITaxon:9606 gomodel:6348a65d00001727/6348a65d00001826 GO:0005125 cytokine activity GO:0090594 inflammatory response to wounding GO:0005576 extracellular region false UniProtKB:Q9H0E7 USP44 Hsap 6348a65d00002142 USP44-mediated STING deubiquitination leading to antiviral innate immune response (Human) NCBITaxon:9606 gomodel:6348a65d00002142/6348a65d00002143 GO:0101005 deubiquitinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 6348a65d00002142 USP44-mediated STING deubiquitination leading to antiviral innate immune response (Human) NCBITaxon:9606 gomodel:6348a65d00002142/6348a65d00002150 GO:0035591 signaling adaptor activity GO:0140374 antiviral innate immune response GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9UHD2 TBK1 Hsap 6348a65d00002142 USP44-mediated STING deubiquitination leading to antiviral innate immune response (Human) NCBITaxon:9606 gomodel:6348a65d00002142/6348a65d00002158 GO:0004674 protein serine/threonine kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9H0E7 USP44 Hsap 6348a65d00002174 USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human) NCBITaxon:9606 gomodel:6348a65d00002174/6348a65d00002175 GO:0101005 deubiquitinase activity GO:0045066 regulatory T cell differentiation GO:0005634 nucleus false UniProtKB:Q9BZS1 FOXP3 Hsap 6348a65d00002174 USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human) NCBITaxon:9606 gomodel:6348a65d00002174/6348a65d00002182 GO:0003700 DNA-binding transcription factor activity GO:0045066 regulatory T cell differentiation GO:0005634 nucleus false UniProtKB:P01137 TGFB1 Hsap 6348a65d00002174 USP44-mediated FOXP3 deubiquitination leading to regulatory T-cell differentiation (Human) NCBITaxon:9606 gomodel:6348a65d00002174/6348a65d00002192 GO:0005125 cytokine activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q9H0E7 USP44 Hsap 6348a65d00002206 USP44-mediated stabilization of DDB2 to Facilitate Nucleotide Excision Repair (Human) NCBITaxon:9606 gomodel:6348a65d00002206/6348a65d00002207 GO:0101005 deubiquitinase activity GO:0006289 nucleotide-excision repair GO:0000785 chromatin false UniProtKB:Q92466 DDB2 Hsap 6348a65d00002206 USP44-mediated stabilization of DDB2 to Facilitate Nucleotide Excision Repair (Human) NCBITaxon:9606 gomodel:6348a65d00002206/6348a65d00002216 GO:0003684 damaged DNA binding GO:0006289 nucleotide-excision repair GO:0000785 chromatin false UniProtKB:Q01831 XPC Hsap 6348a65d00002206 USP44-mediated stabilization of DDB2 to Facilitate Nucleotide Excision Repair (Human) NCBITaxon:9606 gomodel:6348a65d00002206/6348a65d00002224 GO:0140612 DNA damage sensor activity GO:0006289 nucleotide-excision repair GO:0000785 chromatin false UniProtKB:Q9H0E7 USP44 Hsap 6348a65d00002236 USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) NCBITaxon:9606 gomodel:6348a65d00002236/6348a65d00002238 GO:0101005 deubiquitinase activity GO:0045841 negative regulation of mitotic metaphase/anaphase transition GO:0072686 mitotic spindle false UniProtKB:Q12834 CDC20 Hsap 6348a65d00002236 USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) NCBITaxon:9606 gomodel:6348a65d00002236/6348a65d00002247 GO:0010997 anaphase-promoting complex binding GO:0045842 positive regulation of mitotic metaphase/anaphase transition GO:0007094 mitotic spindle assembly checkpoint signaling false UniProtKB:O00762 UBE2C Hsap 6348a65d00002236 USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) NCBITaxon:9606 gomodel:6348a65d00002236/6348a65d00002251 GO:0061631 ubiquitin conjugating enzyme activity GO:0045842 positive regulation of mitotic metaphase/anaphase transition false UniProtKB:Q9NYG5 ANAPC11 Hsap 6348a65d00002236 USP44-mediated deubiquitination of CDC20 controlling anaphase initiation (Human) NCBITaxon:9606 gomodel:6348a65d00002236/6348a65d00002260 GO:0004842 ubiquitin-protein transferase activity GO:0045842 positive regulation of mitotic metaphase/anaphase transition false UniProtKB:Q9BRP0 OVOL2 Hsap 6348a65d00002600 Negative regulation of white adipogenesis by OVOL2. (Human) NCBITaxon:9606 gomodel:6348a65d00002600/6348a65d00002601 GO:0003714 transcription corepressor activity GO:0070351 negative regulation of white fat cell proliferation GO:0005634 nucleus false UniProtKB:P49715 CEBPA Hsap 6348a65d00002600 Negative regulation of white adipogenesis by OVOL2. (Human) NCBITaxon:9606 gomodel:6348a65d00002600/6348a65d00002612 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0070343 white fat cell proliferation GO:0005634 nucleus false UniProtKB:P15090 FABP4 Hsap 6348a65d00002600 Negative regulation of white adipogenesis by OVOL2. (Human) NCBITaxon:9606 gomodel:6348a65d00002600/6348a65d00002843 GO:0005324 long-chain fatty acid transmembrane transporter activity GO:0070343 white fat cell proliferation GO:0005737 cytoplasm false UniProtKB:P14672 SLC2A4 Hsap 6348a65d00002600 Negative regulation of white adipogenesis by OVOL2. (Human) NCBITaxon:9606 gomodel:6348a65d00002600/6348a65d00002853 GO:0055056 D-glucose transmembrane transporter activity GO:0070343 white fat cell proliferation GO:0005886 plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001812 GO:0140299 molecular sensor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001821 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001836 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0016020 membrane false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001847 GO:0070273 phosphatidylinositol-4-phosphate binding GO:0044546 NLRP3 inflammasome complex assembly GO:0016020 membrane false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001857 GO:0140608 cysteine-type endopeptidase activator activity GO:0051604 protein maturation GO:0016020 membrane false UniProtKB:P29466 CASP1 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001870 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001881 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001894 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001910 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001917 GO:0070273 phosphatidylinositol-4-phosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001926 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:Q14116 IL18 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001943 GO:0005125 cytokine activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P01584 IL1B Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001950 GO:0005125 cytokine activity GO:0070498 interleukin-1-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q8TDX7 NEK7 Hsap 635b1e3e00001811 The NLRP3 inflammasome (Human) NCBITaxon:9606 gomodel:635b1e3e00001811/635b1e3e00001959 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:I6WXK4 ptpB NCBITaxon:83332 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002129 GO:0106019 phosphatidylinositol-4,5-bisphosphate phosphatase activity GO:0052041 symbiont-mediated suppression of host programmed cell death GO:0020002 host cell plasma membrane false UniProtKB:I6WXK4 ptpB NCBITaxon:83332 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002138 GO:0043130 ubiquitin binding GO:0052041 symbiont-mediated suppression of host programmed cell death GO:0030430 host cell cytoplasm false UniProtKB:I6WXK4 ptpB NCBITaxon:83332 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002149 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity GO:0052041 symbiont-mediated suppression of host programmed cell death GO:0020002 host cell plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002161 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002168 GO:0070273 phosphatidylinositol-4-phosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 635b1e3e00002003 Inhibition of GSDMD-mediated pyroptosis by M.tuberculosis PtpB phosphatase that alters membrane phospholipid composition (Human and M.tuberculosis) NCBITaxon:9606 gomodel:635b1e3e00002003/635b1e3e00002177 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) NCBITaxon:9606 gomodel:635b1e3e00002004/635b1e3e00002009 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) NCBITaxon:9606 gomodel:635b1e3e00002004/635b1e3e00002014 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0016020 membrane false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) NCBITaxon:9606 gomodel:635b1e3e00002004/635b1e3e00002019 GO:0070273 phosphatidylinositol-4-phosphate binding GO:0044546 NLRP3 inflammasome complex assembly GO:0016020 membrane false UniProtKB:P45983 MAPK8 Hsap 635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) NCBITaxon:9606 gomodel:635b1e3e00002004/635b1e3e00002079 GO:0004674 protein serine/threonine kinase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly false UniProtKB:P46736 BRCC3 Hsap 635b1e3e00002004 Activation of the NLRP3 inflammasome by MAPK8/JNK1 and BRCC3 (Human) NCBITaxon:9606 gomodel:635b1e3e00002004/635b1e3e00002086 GO:0061578 K63-linked deubiquitinase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly false UniProtKB:Q8TDX7 NEK7 Hsap 635b1e3e00002327 CSNK1A1 inhibits formation of the NLRP3 inflammasome by mediating phosphorylation of NLRP3, inhibiting interaction betweeN NLRP3 and NEK7 (Human) NCBITaxon:9606 gomodel:635b1e3e00002327/635b1e3e00002328 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002327 CSNK1A1 inhibits formation of the NLRP3 inflammasome by mediating phosphorylation of NLRP3, inhibiting interaction betweeN NLRP3 and NEK7 (Human) NCBITaxon:9606 gomodel:635b1e3e00002327/635b1e3e00002339 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:P48729 CSNK1A1 Hsap 635b1e3e00002327 CSNK1A1 inhibits formation of the NLRP3 inflammasome by mediating phosphorylation of NLRP3, inhibiting interaction betweeN NLRP3 and NEK7 (Human) NCBITaxon:9606 gomodel:635b1e3e00002327/635b1e3e00002352 GO:0004674 protein serine/threonine kinase activity GO:1900226 negative regulation of NLRP3 inflammasome complex assembly false UniProtKB:Q9BZY9 TRIM31 Hsap 635b1e3e00002360 Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) NCBITaxon:9606 gomodel:635b1e3e00002360/635b1e3e00002361 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002360 Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) NCBITaxon:9606 gomodel:635b1e3e00002360/635b1e3e00002372 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly false UniProtKB:Q9BZY9 TRIM31 Hsap 635b1e3e00002360 Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) NCBITaxon:9606 gomodel:635b1e3e00002360/635b1e3e00002378 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z434 MAVS Hsap 635b1e3e00002360 Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) NCBITaxon:9606 gomodel:635b1e3e00002360/635b1e3e00002385 GO:0140693 molecular condensate scaffold activity GO:0140374 antiviral innate immune response GO:0005739 mitochondrion false UniProtKB:Q96P20 NLRP3 Hsap 635b1e3e00002360 Dual role of TRIM31 that inhibits the NLRP3 inflammasome and indirectly activates it via MAVS (Human) NCBITaxon:9606 gomodel:635b1e3e00002360/635b1e3e00002393 GO:0140693 molecular condensate scaffold activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005739 mitochondrion false UniProtKB:Q86SH2 ZAR1 Hsap 635b1e3e00002404 Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Human) NCBITaxon:9606 gomodel:635b1e3e00002404/635b1e3e00002405 GO:0003730 mRNA 3'-UTR binding GO:0001556 oocyte maturation GO:0005737 cytoplasm false UniProtKB:Q86SH2 ZAR1 Hsap 635b1e3e00002404 Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Human) NCBITaxon:9606 gomodel:635b1e3e00002404/635b1e3e00002409 GO:0140693 molecular condensate scaffold activity GO:0001556 oocyte maturation GO:0005737 cytoplasm false UniProtKB:Q86SH2 ZAR1 Hsap 635b1e3e00002404 Zar1 stores maternal mRNAs in oocytes by mediating formation of a non-membrane bound organelle (Human) NCBITaxon:9606 gomodel:635b1e3e00002404/635b1e3e00002416 GO:0140610 RNA sequestering activity GO:0001556 oocyte maturation GO:0035770 ribonucleoprotein granule false UniProtKB:Q5T6F0 DCAF12 Hsap 636d9ce800001192 DCAF12 controls MOV10 during T cell activation. (Human) NCBITaxon:9606 gomodel:636d9ce800001192/636d9ce800001193 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:Q9HCE1 MOV10 Hsap 636d9ce800001192 DCAF12 controls MOV10 during T cell activation. (Human) NCBITaxon:9606 gomodel:636d9ce800001192/636d9ce800001208 GO:0032574 5'-3' RNA helicase activity GO:0035279 miRNA-mediated gene silencing by mRNA destabilization GO:0005575 cellular_component false UniProtKB:Q13619 CUL4A Hsap 636d9ce800001192 DCAF12 controls MOV10 during T cell activation. (Human) NCBITaxon:9606 gomodel:636d9ce800001192/636d9ce800001459 GO:0160072 ubiquitin ligase complex scaffold activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 636d9ce800001192 DCAF12 controls MOV10 during T cell activation. (Human) NCBITaxon:9606 gomodel:636d9ce800001192/636d9ce800001474 GO:0061630 ubiquitin protein ligase activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:Q5T6F0 DCAF12 Hsap 636d9ce800001222 DCAF12 controls MOV10 during spermatogeneis. (Human) NCBITaxon:9606 gomodel:636d9ce800001222/636d9ce800001223 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005829 cytosol false UniProtKB:Q9HCE1 MOV10 Hsap 636d9ce800001222 DCAF12 controls MOV10 during spermatogeneis. (Human) NCBITaxon:9606 gomodel:636d9ce800001222/636d9ce800001229 GO:0032574 5'-3' RNA helicase activity GO:0035279 miRNA-mediated gene silencing by mRNA destabilization GO:0005575 cellular_component false UniProtKB:Q13619 CUL4A Hsap 636d9ce800001222 DCAF12 controls MOV10 during spermatogeneis. (Human) NCBITaxon:9606 gomodel:636d9ce800001222/636d9ce800001492 GO:0160072 ubiquitin ligase complex scaffold activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 636d9ce800001222 DCAF12 controls MOV10 during spermatogeneis. (Human) NCBITaxon:9606 gomodel:636d9ce800001222/636d9ce800001505 GO:0061630 ubiquitin protein ligase activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:Q96B02 UBE2W Hsap 636d9ce800001276 TRIM7 activation by E2s (Human) NCBITaxon:9606 gomodel:636d9ce800001276/636d9ce800001282 GO:0004842 ubiquitin-protein transferase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P61088 UBE2N Hsap 636d9ce800001276 TRIM7 activation by E2s (Human) NCBITaxon:9606 gomodel:636d9ce800001276/636d9ce800001289 GO:0004842 ubiquitin-protein transferase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9C029 TRIM7 Hsap 636d9ce800001276 TRIM7 activation by E2s (Human) NCBITaxon:9606 gomodel:636d9ce800001276/636d9ce800001324 GO:0061630 ubiquitin protein ligase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q6GPH4 XAF1 Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001445 GO:0140313 molecular sequestering activity GO:0032480 negative regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:P98170 XIAP Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001452 GO:0061630 ubiquitin protein ligase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q53GT1 KLHL22 Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001528 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0032480 negative regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001538 GO:0160072 ubiquitin ligase complex scaffold activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001548 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q92985 IRF7 Hsap 636d9ce800001444 XAF1 prevents hyperproduction of type I interferon by targeting IRF7 (Human) NCBITaxon:9606 gomodel:636d9ce800001444/636d9ce800001556 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q9BYW2 SETD2 Hsap 63894f2500000740 FIP200 ubiquitination by TRIM21 leading to autophagy inhibition (Human) NCBITaxon:9606 gomodel:63894f2500000740/63894f2500000741 GO:0016279 protein-lysine N-methyltransferase activity GO:0010508 positive regulation of autophagy GO:0005737 cytoplasm false UniProtKB:P19474 TRIM21 Hsap 63894f2500000740 FIP200 ubiquitination by TRIM21 leading to autophagy inhibition (Human) NCBITaxon:9606 gomodel:63894f2500000740/63894f2500000748 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q8TDY2 RB1CC1 Hsap 63894f2500000740 FIP200 ubiquitination by TRIM21 leading to autophagy inhibition (Human) NCBITaxon:9606 gomodel:63894f2500000740/63894f2500000755 GO:0019901 protein kinase binding GO:0000045 autophagosome assembly false UniProtKB:P51114 FXR1 Hsap 63894f2500000826 Liquid-liquid phase separation of FXR1 drives spermatogenesis by activating translation of stored mRNAs (Human) NCBITaxon:9606 gomodel:63894f2500000826/63894f2500000827 GO:0035925 mRNA 3'-UTR AU-rich region binding GO:0045727 positive regulation of translation GO:0005737 cytoplasm false UniProtKB:P51114 FXR1 Hsap 63894f2500000826 Liquid-liquid phase separation of FXR1 drives spermatogenesis by activating translation of stored mRNAs (Human) NCBITaxon:9606 gomodel:63894f2500000826/63894f2500000833 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:O43432 EIF4G3 Hsap 63894f2500000826 Liquid-liquid phase separation of FXR1 drives spermatogenesis by activating translation of stored mRNAs (Human) NCBITaxon:9606 gomodel:63894f2500000826/63894f2500000840 GO:0003743 translation initiation factor activity GO:0045727 positive regulation of translation GO:0005737 cytoplasm false UniProtKB:P51114 FXR1 Hsap 63894f2500000870 Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) NCBITaxon:9606 gomodel:63894f2500000870/63894f2500000871 GO:0003730 mRNA 3'-UTR binding GO:0045727 positive regulation of translation GO:0005737 cytoplasm false UniProtKB:P51114 FXR1 Hsap 63894f2500000870 Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) NCBITaxon:9606 gomodel:63894f2500000870/63894f2500000879 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:P60842 EIF4A1 Hsap 63894f2500000870 Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) NCBITaxon:9606 gomodel:63894f2500000870/63894f2500000888 GO:0003743 translation initiation factor activity GO:0002183 cytoplasmic translational initiation GO:0005737 cytoplasm false UniProtKB:Q9UKT5 FBXO4 Hsap 63894f2500000870 Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) NCBITaxon:9606 gomodel:63894f2500000870/63894f2500000899 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P49841 GSK3B Hsap 63894f2500000870 Liquid-liquid phase separation of FXR1 drives translation of mRNAs and regulation of FXR1 by ubiquitination and phosphorylation (Human) NCBITaxon:9606 gomodel:63894f2500000870/63894f2500000914 GO:0004674 protein serine/threonine kinase activity GO:0031398 positive regulation of protein ubiquitination false UniProtKB:Q8IY47 KBTBD2 Hsap 63894f2500001248 Regulation of cellular response to insulin stimulus by ubiquitin ligase-substrate adaptor KBTBD2. (Human) NCBITaxon:9606 gomodel:63894f2500001248/63894f2500001249 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 63894f2500001248 Regulation of cellular response to insulin stimulus by ubiquitin ligase-substrate adaptor KBTBD2. (Human) NCBITaxon:9606 gomodel:63894f2500001248/63894f2500001260 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 63894f2500001248 Regulation of cellular response to insulin stimulus by ubiquitin ligase-substrate adaptor KBTBD2. (Human) NCBITaxon:9606 gomodel:63894f2500001248/63894f2500001274 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P27986 PIK3R1 Hsap 63894f2500001248 Regulation of cellular response to insulin stimulus by ubiquitin ligase-substrate adaptor KBTBD2. (Human) NCBITaxon:9606 gomodel:63894f2500001248/63894f2500001286 GO:0035014 phosphatidylinositol 3-kinase regulator activity GO:0032869 cellular response to insulin stimulus GO:0005737 cytoplasm false UniProtKB:Q99873 PRMT1 Hsap 63894f2500001337 FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001337/63894f2500001338 GO:0008276 protein methyltransferase activity GO:0045727 positive regulation of translation false UniProtKB:Q06787 FMR1 Hsap 63894f2500001337 FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001337/63894f2500001345 GO:0003729 mRNA binding GO:0017148 negative regulation of translation false UniProtKB:Q06787 FMR1 Hsap 63894f2500001337 FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001337/63894f2500001350 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0071598 neuronal ribonucleoprotein granule false UniProtKB:P68400 CSNK2A1 Hsap 63894f2500001337 FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001337/63894f2500001361 GO:0004674 protein serine/threonine kinase activity GO:0017148 negative regulation of translation false UniProtKB:Q13542 EIF4EBP2 Hsap 63894f2500001337 FMR1 undergoes liquid-liquid phase separation upon mRNA-binding, leading to formation of neuronal ribonucleoprotein granules that repress mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001337/63894f2500001369 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation GO:0071598 neuronal ribonucleoprotein granule false UniProtKB:P68400 CSNK2A1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001395 GO:0004674 protein serine/threonine kinase activity GO:0017148 negative regulation of translation false UniProtKB:Q14444 CAPRIN1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001421 GO:0003729 mRNA binding GO:0017148 negative regulation of translation false UniProtKB:Q14444 CAPRIN1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001426 GO:0035591 signaling adaptor activity GO:0017148 negative regulation of translation false UniProtKB:Q14444 CAPRIN1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001438 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:P54764 EPHA4 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001449 GO:0004713 protein tyrosine kinase activity GO:0017148 negative regulation of translation false UniProtKB:Q9UIV1 CNOT7 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001455 GO:0004535 poly(A)-specific ribonuclease activity GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0005737 cytoplasm false UniProtKB:Q06787 FMR1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001505 GO:0003729 mRNA binding GO:0017148 negative regulation of translation false UniProtKB:Q06787 FMR1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001510 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:Q06787 FMR1 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001519 GO:0035591 signaling adaptor activity GO:0017148 negative regulation of translation false UniProtKB:Q13542 EIF4EBP2 Hsap 63894f2500001378 FMR1 and CAPRIN1 undergo liquid-liquid phase separation following phosphorylation, leading to formation of non-membrane-bounded organelle that prevent mRNA translation (Human) NCBITaxon:9606 gomodel:63894f2500001378/63894f2500001530 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation GO:0005737 cytoplasm false UniProtKB:Q9HCE5 METTL14 Hsap 63894f2500001748 FRM1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Human) NCBITaxon:9606 gomodel:63894f2500001748/63894f2500001749 GO:0003729 mRNA binding GO:0016556 mRNA modification GO:0005634 nucleus false UniProtKB:Q86U44 METTL3 Hsap 63894f2500001748 FRM1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Human) NCBITaxon:9606 gomodel:63894f2500001748/63894f2500001761 GO:0001734 mRNA m(6)A methyltransferase activity GO:0016556 mRNA modification GO:0005634 nucleus false UniProtKB:Q06787 FMR1 Hsap 63894f2500001748 FRM1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Human) NCBITaxon:9606 gomodel:63894f2500001748/63894f2500001774 GO:1990247 N6-methyladenosine-containing RNA reader activity GO:0006406 mRNA export from nucleus GO:0005634 nucleus false UniProtKB:O14980 XPO1 Hsap 63894f2500001748 FRM1 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their nuclear export (Human) NCBITaxon:9606 gomodel:63894f2500001748/63894f2500001783 GO:0005049 nuclear export signal receptor activity GO:0006406 mRNA export from nucleus false UniProtKB:Q6PJ69 TRIM65 Hsap 63894f2500001894 ARRDC4-mediated activation of MDA5 through K63-ubiquitination by TRIM65 (Human) NCBITaxon:9606 gomodel:63894f2500001894/63894f2500001898 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q8NCT1 ARRDC4 Hsap 63894f2500001894 ARRDC4-mediated activation of MDA5 through K63-ubiquitination by TRIM65 (Human) NCBITaxon:9606 gomodel:63894f2500001894/63894f2500001912 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 63894f2500001894 ARRDC4-mediated activation of MDA5 through K63-ubiquitination by TRIM65 (Human) NCBITaxon:9606 gomodel:63894f2500001894/63894f2500001921 GO:0035591 signaling adaptor activity GO:0032728 positive regulation of interferon-beta production GO:0031966 mitochondrial membrane false UniProtKB:Q6PJ69 TRIM65 Hsap 639bc18f00000028 VCAM1 ubiquitination by TRIM65 leading to inflammation inhibition (Human) NCBITaxon:9606 gomodel:639bc18f00000028/639bc18f00000029 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P19320 VCAM1 Hsap 639bc18f00000028 VCAM1 ubiquitination by TRIM65 leading to inflammation inhibition (Human) NCBITaxon:9606 gomodel:639bc18f00000028/639bc18f00000036 GO:0098631 cell adhesion mediator activity GO:0006954 inflammatory response GO:0005886 plasma membrane false UniProtKB:P63000 RAC1 Hsap 639bc18f00000028 VCAM1 ubiquitination by TRIM65 leading to inflammation inhibition (Human) NCBITaxon:9606 gomodel:639bc18f00000028/639bc18f00000043 GO:0003924 GTPase activity GO:0006954 inflammatory response GO:0005886 plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 639bc18f00000054 NLRP3 'Lys-27'-linked ubiquitination by MARCHF5 leading to activation of inflammasome formation (Human) NCBITaxon:9606 gomodel:639bc18f00000054/639bc18f00000066 GO:0060090 molecular adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q8TDX7 NEK7 Hsap 639bc18f00000054 NLRP3 'Lys-27'-linked ubiquitination by MARCHF5 leading to activation of inflammasome formation (Human) NCBITaxon:9606 gomodel:639bc18f00000054/639bc18f00000075 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q9NX47 MARCHF5 Hsap 639bc18f00000054 NLRP3 'Lys-27'-linked ubiquitination by MARCHF5 leading to activation of inflammasome formation (Human) NCBITaxon:9606 gomodel:639bc18f00000054/678073a900001458 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005741 mitochondrial outer membrane false UniProtKB:P19474 TRIM21 Hsap 639bc18f00000090 Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000090/639bc18f00000091 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P40305 IFI27 Hsap 639bc18f00000090 Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000090/639bc18f00000098 GO:0060090 molecular adaptor activity GO:0070269 pyroptotic inflammatory response GO:0005739 mitochondrion false UniProtKB:P42574 CASP3 Hsap 639bc18f00000090 Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000090/639bc18f00000110 GO:0004197 cysteine-type endopeptidase activity GO:0070269 pyroptotic inflammatory response GO:0005737 cytoplasm false UniProtKB:O60443 GSDME Hsap 639bc18f00000090 Isg12a K6-ubiquitination by TRIM21 leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000090/639bc18f00000121 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:Q9Y2G2 CARD8 Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000694 GO:0038187 pattern recognition receptor activity GO:0140633 CARD8 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q9Y2G2 CARD8 Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000701 GO:0140693 molecular condensate scaffold activity GO:0140633 CARD8 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q9Y2G2 CARD8 Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000708 GO:0140608 cysteine-type endopeptidase activator activity GO:0140633 CARD8 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:P29466 CASP1 Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000719 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000728 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000743 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000752 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P04585-PRO_0000038665 gag-pol-Protease NCBITaxon:11706 639bc18f00000693 Activation of the CARD8 inflammasome by HIV-1 protease, leading to pyroptosis (Human) NCBITaxon:9606 gomodel:639bc18f00000693/639bc18f00000760 GO:0004190 aspartic-type endopeptidase activity GO:0016485 protein processing false UniProtKB:O95786 RIGI Hsap 63a86a8600000489 TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human) NCBITaxon:9606 gomodel:63a86a8600000489/63a86a8600000490 GO:0038187 pattern recognition receptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q8IYM9 TRIM22 Hsap 63a86a8600000489 TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human) NCBITaxon:9606 gomodel:63a86a8600000489/63a86a8600000509 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P49902 NT5C2 Hsap 63a86a8600000489 TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human) NCBITaxon:9606 gomodel:63a86a8600000489/63a86a8600000522 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 63a86a8600000489 TRIM22-NT5C2 regulation of RIGI via ubiquitination (Human) NCBITaxon:9606 gomodel:63a86a8600000489/63a86a8600000534 GO:0035591 signaling adaptor activity GO:0140374 antiviral innate immune response GO:0031966 mitochondrial membrane false UniProtKB:O60231 DHX16 Hsap 63a86a8600001202 DHX16-mediated viral RNA recognition and activation of RIGI (Human) NCBITaxon:9606 gomodel:63a86a8600001202/63a86a8600001203 GO:0038187 pattern recognition receptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9C030 TRIM6 Hsap 63a86a8600001202 DHX16-mediated viral RNA recognition and activation of RIGI (Human) NCBITaxon:9606 gomodel:63a86a8600001202/63a86a8600001210 GO:0061630 ubiquitin protein ligase activity GO:0010994 free ubiquitin chain polymerization GO:0005737 cytoplasm false UniProtKB:O60231 DHX16 Hsap 63a86a8600001202 DHX16-mediated viral RNA recognition and activation of RIGI (Human) NCBITaxon:9606 gomodel:63a86a8600001202/63a86a8600001217 GO:0060090 molecular adaptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:O95786 RIGI Hsap 63a86a8600001202 DHX16-mediated viral RNA recognition and activation of RIGI (Human) NCBITaxon:9606 gomodel:63a86a8600001202/63a86a8600001224 GO:0038187 pattern recognition receptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:O60231 DHX16 Hsap 63a86a8600001202 DHX16-mediated viral RNA recognition and activation of RIGI (Human) NCBITaxon:9606 gomodel:63a86a8600001202/63a86a8600001236 GO:0043130 ubiquitin binding GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:O15455 TLR3 Hsap 63a86a8600001248 TRIM3-mediated ubiquitination of TLR3 leading to TLR3 activation (Human) NCBITaxon:9606 gomodel:63a86a8600001248/63a86a8600001250 GO:0038187 pattern recognition receptor activity GO:0002224 toll-like receptor signaling pathway GO:0005769 early endosome false UniProtKB:O75382 TRIM3 Hsap 63a86a8600001248 TRIM3-mediated ubiquitination of TLR3 leading to TLR3 activation (Human) NCBITaxon:9606 gomodel:63a86a8600001248/63a86a8600001257 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005794 Golgi apparatus false UniProtKB:Q8IUC6 TICAM1 Hsap 63a86a8600001248 TRIM3-mediated ubiquitination of TLR3 leading to TLR3 activation (Human) NCBITaxon:9606 gomodel:63a86a8600001248/63a86a8600001271 GO:0060090 molecular adaptor activity GO:0002224 toll-like receptor signaling pathway GO:0005769 early endosome false UniProtKB:O43318 MAP3K7 Hsap 63a86a8600001279 NF-kappa-B inhibition by TRIM15 sequestering of TRIM8 in the nucleus (Human) NCBITaxon:9606 gomodel:63a86a8600001279/63a86a8600001285 GO:0004707 MAP kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9BZR9 TRIM8 Hsap 63a86a8600001279 NF-kappa-B inhibition by TRIM15 sequestering of TRIM8 in the nucleus (Human) NCBITaxon:9606 gomodel:63a86a8600001279/63a86a8600001292 GO:0061630 ubiquitin protein ligase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9C019 TRIM15 Hsap 63a86a8600001279 NF-kappa-B inhibition by TRIM15 sequestering of TRIM8 in the nucleus (Human) NCBITaxon:9606 gomodel:63a86a8600001279/63a86a8600001301 GO:0140313 molecular sequestering activity GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:O43318 MAP3K7 Hsap 63a86a8600001314 TRIM56 activation of NK-kappa-B signaling via MAP3K7 (Human) NCBITaxon:9606 gomodel:63a86a8600001314/63a86a8600001315 GO:1990450 linear polyubiquitin binding GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9BRZ2 TRIM56 Hsap 63a86a8600001314 TRIM56 activation of NK-kappa-B signaling via MAP3K7 (Human) NCBITaxon:9606 gomodel:63a86a8600001314/63a86a8600001319 GO:0061630 ubiquitin protein ligase activity GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O15111 CHUK Hsap 63a86a8600001314 TRIM56 activation of NK-kappa-B signaling via MAP3K7 (Human) NCBITaxon:9606 gomodel:63a86a8600001314/63a86a8600001338 GO:0004672 protein kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P49662 CASP4 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001654 GO:0008289 lipid binding GO:0042742 defense response to bacterium GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001663 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001674 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001691 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001699 GO:0022829 wide pore channel activity GO:0009306 protein secretion GO:0005886 plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/63a86a8600001707 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0016020 membrane false UniProtKB:P49662 CASP4 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/654d809000002714 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:Q14116 IL18 Hsap 63a86a8600001653 The non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding (Human) NCBITaxon:9606 gomodel:63a86a8600001653/654d809000002743 GO:0005125 cytokine activity GO:0035655 interleukin-18-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P32456 GBP2 Hsap 63a86a8600001780 GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) NCBITaxon:9606 gomodel:63a86a8600001780/63a86a8600001781 GO:0140678 molecular function inhibitor activity GO:0051607 defense response to virus GO:0000139 Golgi membrane false UniProtKB:Q96PP8 GBP5 Hsap 63a86a8600001780 GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) NCBITaxon:9606 gomodel:63a86a8600001780/63a86a8600001790 GO:0140678 molecular function inhibitor activity GO:0051607 defense response to virus GO:0000139 Golgi membrane false UniProtKB:P09958 FURIN Hsap 63a86a8600001780 GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) NCBITaxon:9606 gomodel:63a86a8600001780/63a86a8600001799 GO:0004175 endopeptidase activity GO:0051604 protein maturation false UniProtKB:P04578-PRO_0000038427 env-SU NCBITaxon:11706 63a86a8600001780 GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) NCBITaxon:9606 gomodel:63a86a8600001780/6796b94c00005147 GO:0048018 receptor ligand activity GO:0046718 symbiont entry into host cell GO:0020002 host cell plasma membrane false UniProtKB:P01730 CD4 Hsap 63a86a8600001780 GBP2 and GBP5 inhibit FURIN-mediated cleavage of HIV-1 envelope protein, inhibiting viral infectivity (Human) NCBITaxon:9606 gomodel:63a86a8600001780/6796b94c00005164 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0005886 plasma membrane false UniProtKB:O14862 AIM2 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000009 GO:0003690 double-stranded DNA binding GO:0140970 AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:O14862 AIM2 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000016 GO:0038187 pattern recognition receptor activity GO:0140970 AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:O14862 AIM2 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000023 GO:0035591 signaling adaptor activity GO:0140970 AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:O14862 AIM2 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000032 GO:0140608 cysteine-type endopeptidase activator activity GO:0140970 AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:P29466 CASP1 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000044 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P29466 CASP1 Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000056 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000068 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 63c0ac2b00000008 The AIM2 inflammasome (Human) NCBITaxon:9606 gomodel:63c0ac2b00000008/63c0ac2b00000078 GO:0022829 wide pore channel activity GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000268 GO:0003925 G protein activity GO:0042742 defense response to bacterium false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000273 GO:0030674 protein-macromolecule adaptor activity GO:0042742 defense response to bacterium false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000287 GO:0043539 protein serine/threonine kinase activator activity GO:0042742 defense response to bacterium false UniProtKB:Q13131 PRKAA1 Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000297 GO:0004674 protein serine/threonine kinase activity GO:0010508 positive regulation of autophagy false UniProtKB:O75385 ULK1 Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000307 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q14457 BECN1 Hsap 63c0ac2b00000267 IRGM governs the core autophagy machinery to conduct antimicrobial defense (Human) NCBITaxon:9606 gomodel:63c0ac2b00000267/63c0ac2b00000320 GO:0030674 protein-macromolecule adaptor activity GO:0065003 protein-containing complex assembly GO:0005776 autophagosome false UniProtKB:Q8VSC3 ipaH9.8 SHIFL 63c0ac2b00000331 IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) NCBITaxon:9606 gomodel:63c0ac2b00000331/63c0ac2b00000332 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0044164 host cell cytosol false UniProtKB:P32455 GBP1 Hsap 63c0ac2b00000331 IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) NCBITaxon:9606 gomodel:63c0ac2b00000331/63c0ac2b00000377 GO:0003924 GTPase activity GO:0051715 cytolysis in another organism GO:0031410 cytoplasmic vesicle false UniProtKB:P49662 CASP4 Hsap 63c0ac2b00000331 IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) NCBITaxon:9606 gomodel:63c0ac2b00000331/63c0ac2b00000440 GO:0008289 lipid binding GO:0160075 non-canonical inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 63c0ac2b00000331 IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) NCBITaxon:9606 gomodel:63c0ac2b00000331/63c0ac2b00000450 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P32455 GBP1 Hsap 63c0ac2b00000331 IpaH9.8 effector protein from S.flexneri ubiquitinate host GBP1, leading to its degradation and inhibition of innate immunity (Human and S.flexneri) NCBITaxon:9606 gomodel:63c0ac2b00000331/65692e7e00000032 GO:0001530 lipopolysaccharide binding GO:0160075 non-canonical inflammasome complex assembly GO:0031410 cytoplasmic vesicle false UniProtKB:Q96F44 TRIM11 Hsap 63c0ac2b00000385 TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via SQSTM1 dependent selective autophagy (Human) NCBITaxon:9606 gomodel:63c0ac2b00000385/63c0ac2b00000386 GO:0004842 ubiquitin-protein transferase activity GO:0051865 protein autoubiquitination GO:0005737 cytoplasm false UniProtKB:Q96F44 TRIM11 Hsap 63c0ac2b00000385 TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via SQSTM1 dependent selective autophagy (Human) NCBITaxon:9606 gomodel:63c0ac2b00000385/63c0ac2b00000395 GO:0030674 protein-macromolecule adaptor activity GO:0140972 negative regulation of AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q13501 SQSTM1 Hsap 63c0ac2b00000385 TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via SQSTM1 dependent selective autophagy (Human) NCBITaxon:9606 gomodel:63c0ac2b00000385/63c0ac2b00000417 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q96MT8 CEP63 Hsap 63c0ac2b00000464 Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) NCBITaxon:9606 gomodel:63c0ac2b00000464/63c0ac2b00000465 GO:0060090 molecular adaptor activity GO:0045824 negative regulation of innate immune response GO:0005813 centrosome false UniProtKB:Q9Y2E6 DTX4 Hsap 63c0ac2b00000464 Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) NCBITaxon:9606 gomodel:63c0ac2b00000464/63c0ac2b00000474 GO:0061630 ubiquitin protein ligase activity GO:0045824 negative regulation of innate immune response GO:0005813 centrosome false UniProtKB:Q9UHD2 TBK1 Hsap 63c0ac2b00000464 Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) NCBITaxon:9606 gomodel:63c0ac2b00000464/63c0ac2b00000484 GO:0004674 protein serine/threonine kinase activity GO:0045087 innate immune response GO:0005737 cytoplasm false UniProtKB:A0A024B7W1 A0A024B7W1 NCBITaxon:2043570 63c0ac2b00000464 Zika virus inhibition of TBK1 via CEP63 binding and centrosome disorganization (Human-Zika virus) NCBITaxon:9606 gomodel:63c0ac2b00000464/63c0ac2b00000494 GO:0060090 molecular adaptor activity GO:0045824 negative regulation of innate immune response GO:0005813 centrosome false UniProtKB:P0C2W1 FBXO45 Hsap 63c0ac2b00000506 Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human) NCBITaxon:9606 gomodel:63c0ac2b00000506/63c0ac2b00000507 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0016567 protein ubiquitination GO:0005737 cytoplasm false UniProtKB:O75592 MYCBP2 Hsap 63c0ac2b00000506 Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human) NCBITaxon:9606 gomodel:63c0ac2b00000506/63c0ac2b00000514 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9BZQ4 NMNAT2 Hsap 63c0ac2b00000506 Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human) NCBITaxon:9606 gomodel:63c0ac2b00000506/63c0ac2b00000521 GO:0004515 nicotinate-nucleotide adenylyltransferase activity GO:0061564 axon development GO:0005794 Golgi apparatus false UniProtKB:P63208 SKP1 Hsap 63c0ac2b00000506 Degradation of NMNAT2 via the PAM (SKP1-FBXO45-MYCBP2) E3 ligase complex (Human) NCBITaxon:9606 gomodel:63c0ac2b00000506/63c0ac2b00000536 GO:0140677 molecular function activator activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9UKV5 AMFR Hsap 63c0ac2b00000547 Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) NCBITaxon:9606 gomodel:63c0ac2b00000547/63c0ac2b00000548 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8N5C8 TAB3 Hsap 63c0ac2b00000547 Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) NCBITaxon:9606 gomodel:63c0ac2b00000547/63c0ac2b00000559 GO:0060090 molecular adaptor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005783 endoplasmic reticulum false UniProtKB:Q2FVK1 hlgB STAA8 63c0ac2b00000547 Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) NCBITaxon:9606 gomodel:63c0ac2b00000547/63c0ac2b00000568 GO:0060090 molecular adaptor activity GO:0085032 symbiont-mediated perturbation of host NF-kappaB cascade GO:0044165 host cell endoplasmic reticulum false UniProtKB:O43318 MAP3K7 Hsap 63c0ac2b00000547 Staphylococcal HlgB activation of NF-kappa-B via AMFR and TAB3 (Human-Staphylococcus Aureus) NCBITaxon:9606 gomodel:63c0ac2b00000547/63c0ac2b00000583 GO:0004707 MAP kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P61086 UBE2K Hsap 63c0ac2b00000593 TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human) NCBITaxon:9606 gomodel:63c0ac2b00000593/63c0ac2b00000594 GO:0004842 ubiquitin-protein transferase activity GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9C030 TRIM6 Hsap 63c0ac2b00000593 TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human) NCBITaxon:9606 gomodel:63c0ac2b00000593/63c0ac2b00000601 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q14164 IKBKE Hsap 63c0ac2b00000593 TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human) NCBITaxon:9606 gomodel:63c0ac2b00000593/63c0ac2b00000609 GO:0004674 protein serine/threonine kinase activity GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P42224 STAT1 Hsap 63c0ac2b00000593 TRIM6 activation of antiviral response via unanchored K48-linked polyubiquitin (Human) NCBITaxon:9606 gomodel:63c0ac2b00000593/63c0ac2b00000623 GO:0003700 DNA-binding transcription factor activity GO:0060337 type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P63104 YWHAZ Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000642 GO:0050815 phosphoserine residue binding GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P63104 YWHAZ Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000655 GO:0140311 protein sequestering activity GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P19484 TFEB Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000668 GO:0003700 DNA-binding transcription factor activity GO:0007040 lysosome organization GO:0005634 nucleus false UniProtKB:P16298 PPP3CB Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000686 GO:0033192 calmodulin-dependent protein phosphatase activity GO:1900182 positive regulation of protein localization to nucleus GO:0005737 cytoplasm false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000708 GO:0030674 protein-macromolecule adaptor activity GO:0042742 defense response to bacterium false UniProtKB:Q9GZU1 MCOLN1 Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000720 GO:0099604 ligand-gated calcium channel activity GO:1901660 calcium ion export GO:0005765 lysosomal membrane false UniProtKB:P16298 PPP3CB Hsap 63c0ac2b00000641 Lysosome biogenesis by TFEB and regulation of nuclear translocation via dephosphorylation by PPP3CB and regulation by IRGM (Human) NCBITaxon:9606 gomodel:63c0ac2b00000641/63c0ac2b00000729 GO:0005516 calmodulin binding GO:1905673 positive regulation of lysosome organization GO:0005737 cytoplasm false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001157 GO:0030674 protein-macromolecule adaptor activity GO:0050687 negative regulation of defense response to virus GO:0000421 autophagosome membrane false UniProtKB:Q13501 SQSTM1 Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001163 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001183 GO:0140036 ubiquitin-modified protein reader activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001196 GO:0030674 protein-macromolecule adaptor activity GO:0050687 negative regulation of defense response to virus GO:0000421 autophagosome membrane false UniProtKB:A1A4Y4 IRGM Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001209 GO:0030674 protein-macromolecule adaptor activity GO:0050687 negative regulation of defense response to virus GO:0000421 autophagosome membrane false UniProtKB:Q13501 SQSTM1 Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001222 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/63c0ac2b00001235 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q9C0B5 ZDHHC5 Hsap 63c0ac2b00001143 IRGM promotes autophagy-dependent degradation of RIPosomes (NOD1, NOD2 and RIPK2) (Human) NCBITaxon:9606 gomodel:63c0ac2b00001143/641ce4dc00000633 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0072659 protein localization to plasma membrane GO:0005886 plasma membrane false UniProtKB:Q96GR4 ZDHHC12 Hsap 63c0ac2b00001252 Palmitoylation of NLRP3 by ZDHHC12, leading to NLRP3 degradation by the chaperone-mediated autophagy process (Human) NCBITaxon:9606 gomodel:63c0ac2b00001252/63c0ac2b00001253 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:1900226 negative regulation of NLRP3 inflammasome complex assembly false UniProtKB:P11142 HSPA8 Hsap 63c0ac2b00001252 Palmitoylation of NLRP3 by ZDHHC12, leading to NLRP3 degradation by the chaperone-mediated autophagy process (Human) NCBITaxon:9606 gomodel:63c0ac2b00001252/63c0ac2b00001260 GO:0030674 protein-macromolecule adaptor activity GO:0061740 protein targeting to lysosome involved in chaperone-mediated autophagy false UniProtKB:P13473-1 LAMP2 Hsap 63c0ac2b00001252 Palmitoylation of NLRP3 by ZDHHC12, leading to NLRP3 degradation by the chaperone-mediated autophagy process (Human) NCBITaxon:9606 gomodel:63c0ac2b00001252/63c0ac2b00001271 GO:0035591 signaling adaptor activity GO:0061684 chaperone-mediated autophagy GO:0005765 lysosomal membrane false UniProtKB:Q9NV06 DCAF13 Hsap 63c0ac2b00001566 DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001566/63c0ac2b00001567 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005730 nucleolus false UniProtKB:O43463 SUV39H1 Hsap 63c0ac2b00001566 DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001566/63c0ac2b00001576 GO:0140949 histone H3K9 trimethyltransferase activity GO:0044725 epigenetic programming in the zygotic pronuclei GO:0005634 nucleus false UniProtKB:Q9H5I1 SUV39H2 Hsap 63c0ac2b00001566 DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001566/63c0ac2b00001585 GO:0140949 histone H3K9 trimethyltransferase activity GO:0044725 epigenetic programming in the zygotic pronuclei GO:0005634 nucleus false UniProtKB:Q16531 DDB1 Hsap 63c0ac2b00001566 DCAF13 regulates chromatin reprogramming in the zygote through SUV39H1 and SUV39H2 degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001566/63c0ac2b00001592 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001755 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q9UK97 FBXO9 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001762 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:P63208 SKP1 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001771 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q13616 CUL1 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001788 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q86X55 CARM1 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001796 GO:0008276 protein methyltransferase activity GO:1904037 positive regulation of epithelial cell apoptotic process false UniProtKB:P42574 CASP3 Hsap 63c0ac2b00001613 FBXO9-mediated degradation of CARM1 leading to epithelial cell survival (Human) NCBITaxon:9606 gomodel:63c0ac2b00001613/63c0ac2b00001804 GO:0004197 cysteine-type endopeptidase activity GO:0006915 apoptotic process GO:0005737 cytoplasm false UniProtKB:Q9NV06 DCAF13 Hsap 63c0ac2b00001634 DCAF13 supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting PTEN polyubiquitination and degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001634/63c0ac2b00001635 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005730 nucleolus false UniProtKB:P60484 PTEN Hsap 63c0ac2b00001634 DCAF13 supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting PTEN polyubiquitination and degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001634/63c0ac2b00001645 GO:0052866 phosphatidylinositol phosphate phosphatase activity GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005575 cellular_component false UniProtKB:Q16531 DDB1 Hsap 63c0ac2b00001634 DCAF13 supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting PTEN polyubiquitination and degradation. (Human) NCBITaxon:9606 gomodel:63c0ac2b00001634/63c0ac2b00001649 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005730 nucleolus false UniProtKB:P62877 RBX1 Hsap 63c0ac2b00001853 FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) NCBITaxon:9606 gomodel:63c0ac2b00001853/63c0ac2b00001854 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q9Y3I1 FBXO7 Hsap 63c0ac2b00001853 FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) NCBITaxon:9606 gomodel:63c0ac2b00001853/63c0ac2b00001857 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:P63208 SKP1 Hsap 63c0ac2b00001853 FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) NCBITaxon:9606 gomodel:63c0ac2b00001853/63c0ac2b00001860 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:Q13616 CUL1 Hsap 63c0ac2b00001853 FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) NCBITaxon:9606 gomodel:63c0ac2b00001853/63c0ac2b00001863 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:Q9NRC8 SIRT7 Hsap 63c0ac2b00001853 FBXO7-mediated degradation of SIRT7 leading to cell death in response to hydrogen peroxide (Human) NCBITaxon:9606 gomodel:63c0ac2b00001853/63c0ac2b00001866 GO:0008276 protein methyltransferase activity GO:0005634 nucleus false UniProtKB:Q0D2I5 IFFO1 Hsap 63c0ac2b00002148 IFFO1 immobilizes broken DNA for reparation (Human) NCBITaxon:9606 gomodel:63c0ac2b00002148/63c0ac2b00002149 GO:0008093 cytoskeletal adaptor activity GO:1990683 DNA double-strand break attachment to nuclear envelope GO:0035861 site of double-strand break false UniProtKB:Q13426 XRCC4 Hsap 63c0ac2b00002148 IFFO1 immobilizes broken DNA for reparation (Human) NCBITaxon:9606 gomodel:63c0ac2b00002148/63c0ac2b00002152 GO:0030674 protein-macromolecule adaptor activity GO:1990683 DNA double-strand break attachment to nuclear envelope GO:0035861 site of double-strand break false UniProtKB:P02545 LMNA Hsap 63c0ac2b00002148 IFFO1 immobilizes broken DNA for reparation (Human) NCBITaxon:9606 gomodel:63c0ac2b00002148/63c0ac2b00002154 GO:0005200 structural constituent of cytoskeleton GO:1990683 DNA double-strand break attachment to nuclear envelope GO:0005652 nuclear lamina false UniProtKB:P31749 AKT1 Hsap 63d320cd00001536 FBXL19-mediated degradation of RAC1 (Human) NCBITaxon:9606 gomodel:63d320cd00001536/63d320cd00001537 GO:0004674 protein serine/threonine kinase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q6PCT2 FBXL19 Hsap 63d320cd00001536 FBXL19-mediated degradation of RAC1 (Human) NCBITaxon:9606 gomodel:63d320cd00001536/63d320cd00001546 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P63000 RAC1 Hsap 63d320cd00001536 FBXL19-mediated degradation of RAC1 (Human) NCBITaxon:9606 gomodel:63d320cd00001536/63d320cd00001556 GO:0003924 GTPase activity GO:0016477 cell migration GO:0005737 cytoplasm false UniProtKB:P49841 GSK3B Hsap 63d320cd00001588 FBXL19-mediated degradation of IL1R1 via GSK3B (Human) NCBITaxon:9606 gomodel:63d320cd00001588/63d320cd00001589 GO:0004674 protein serine/threonine kinase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q6PCT2 FBXL19 Hsap 63d320cd00001588 FBXL19-mediated degradation of IL1R1 via GSK3B (Human) NCBITaxon:9606 gomodel:63d320cd00001588/63d320cd00001594 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q01638 IL1RL1 Hsap 63d320cd00001588 FBXL19-mediated degradation of IL1R1 via GSK3B (Human) NCBITaxon:9606 gomodel:63d320cd00001588/63d320cd00001622 GO:0002114 interleukin-33 receptor activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96BH1 RNF25 Hsap 63d320cd00001688 Response to ribosome stalling by GCN1, RNF14 and RNF25, leading to ubiquitination and degradation of EEF1A1 (Human) NCBITaxon:9606 gomodel:63d320cd00001688/63d320cd00001694 GO:0061630 ubiquitin protein ligase activity GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:Q92616 GCN1 Hsap 63d320cd00001688 Response to ribosome stalling by GCN1, RNF14 and RNF25, leading to ubiquitination and degradation of EEF1A1 (Human) NCBITaxon:9606 gomodel:63d320cd00001688/63d320cd00001703 GO:0170011 stalled ribosome sensor activity GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS8 RNF14 Hsap 63d320cd00001688 Response to ribosome stalling by GCN1, RNF14 and RNF25, leading to ubiquitination and degradation of EEF1A1 (Human) NCBITaxon:9606 gomodel:63d320cd00001688/63d320cd00001710 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0022626 cytosolic ribosome false UniProtKB:P68104 EEF1A1 Hsap 63d320cd00001688 Response to ribosome stalling by GCN1, RNF14 and RNF25, leading to ubiquitination and degradation of EEF1A1 (Human) NCBITaxon:9606 gomodel:63d320cd00001688/63d320cd00001725 GO:0003746 translation elongation factor activity GO:0006414 translational elongation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS8 RNF14 Hsap 63d320cd00001733 Response to ribosome stalling by RNF14 and RNF25, leading to ubiquitination and degradation of ETF1 (Human) NCBITaxon:9606 gomodel:63d320cd00001733/63d320cd00001734 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0022626 cytosolic ribosome false UniProtKB:Q96BH1 RNF25 Hsap 63d320cd00001733 Response to ribosome stalling by RNF14 and RNF25, leading to ubiquitination and degradation of ETF1 (Human) NCBITaxon:9606 gomodel:63d320cd00001733/63d320cd00001748 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0022626 cytosolic ribosome false UniProtKB:P62495 ETF1 Hsap 63d320cd00001733 Response to ribosome stalling by RNF14 and RNF25, leading to ubiquitination and degradation of ETF1 (Human) NCBITaxon:9606 gomodel:63d320cd00001733/63d320cd00001768 GO:0003747 translation release factor activity GO:0006415 translational termination GO:0022626 cytosolic ribosome false UniProtKB:Q9P2K8 EIF2AK4 Hsap 63d320cd00001779 Activation of the kinase activity of EIF2AK4/GCN2 by GCN1 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:63d320cd00001779/63d320cd00001785 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140469 GCN2-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 63d320cd00001779 Activation of the kinase activity of EIF2AK4/GCN2 by GCN1 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:63d320cd00001779/63d320cd00001790 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q92616 GCN1 Hsap 63d320cd00001779 Activation of the kinase activity of EIF2AK4/GCN2 by GCN1 in response to ribosome collisions (Human) NCBITaxon:9606 gomodel:63d320cd00001779/63d320cd00001816 GO:0170011 stalled ribosome sensor activity GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:Q86UK7 ZNF598 Hsap 63e5937500000591 Activation of the ribosome quality control by ZNF598 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of ASCC2 and ASCC3 (Human) NCBITaxon:9606 gomodel:63e5937500000591/63e5937500000592 GO:0170011 stalled ribosome sensor activity GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:Q86UK7 ZNF598 Hsap 63e5937500000591 Activation of the ribosome quality control by ZNF598 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of ASCC2 and ASCC3 (Human) NCBITaxon:9606 gomodel:63e5937500000591/63e5937500000599 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0022626 cytosolic ribosome false UniProtKB:Q9H1I8 ASCC2 Hsap 63e5937500000591 Activation of the ribosome quality control by ZNF598 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of ASCC2 and ASCC3 (Human) NCBITaxon:9606 gomodel:63e5937500000591/63e5937500000610 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:Q8N3C0 ASCC3 Hsap 63e5937500000591 Activation of the ribosome quality control by ZNF598 in response to ribosome collisions, leading to ubiquitination of RPS20/us10 and ribosome dissociation by the RQT complex, composed of ASCC2 and ASCC3 (Human) NCBITaxon:9606 gomodel:63e5937500000591/63e5937500000621 GO:0016887 ATP hydrolysis activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:Q86UK7 ZNF598 Hsap 63e5937500000997 Inhibition of translation initiation of defective mRNAs by GIGYF2 and EIF4E2 to assist ribosome-associated quality control. (Human) NCBITaxon:9606 gomodel:63e5937500000997/63e5937500000998 GO:0140517 protein-RNA adaptor activity GO:0045947 negative regulation of translational initiation false UniProtKB:Q6Y7W6 GIGYF2 Hsap 63e5937500000997 Inhibition of translation initiation of defective mRNAs by GIGYF2 and EIF4E2 to assist ribosome-associated quality control. (Human) NCBITaxon:9606 gomodel:63e5937500000997/63e5937500001005 GO:0060090 molecular adaptor activity GO:0045947 negative regulation of translational initiation false UniProtKB:O60573 EIF4E2 Hsap 63e5937500000997 Inhibition of translation initiation of defective mRNAs by GIGYF2 and EIF4E2 to assist ribosome-associated quality control. (Human) NCBITaxon:9606 gomodel:63e5937500000997/63e5937500001019 GO:0000340 RNA 7-methylguanosine cap binding GO:0045947 negative regulation of translational initiation false UniProtKB:P0DTD1-PRO_0000449620 nsp2 Scov2 63e5937500001029 Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection. (Human/Sars-CoV-2) NCBITaxon:9606 gomodel:63e5937500001029/63e5937500001030 GO:0060090 molecular adaptor activity GO:0039606 symbiont-mediated suppression of host translation initiation false UniProtKB:Q6Y7W6 GIGYF2 Hsap 63e5937500001029 Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection. (Human/Sars-CoV-2) NCBITaxon:9606 gomodel:63e5937500001029/63e5937500001034 GO:0060090 molecular adaptor activity GO:0045947 negative regulation of translational initiation false UniProtKB:O60573 EIF4E2 Hsap 63e5937500001029 Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection. (Human/Sars-CoV-2) NCBITaxon:9606 gomodel:63e5937500001029/63e5937500001041 GO:0000340 RNA 7-methylguanosine cap binding GO:0045947 negative regulation of translational initiation false UniProtKB:P01574 IFNB1 Hsap 63e5937500001029 Inhibition of IFNB1 translation initiation by EIF4E2 in response to viral infection. (Human/Sars-CoV-2) NCBITaxon:9606 gomodel:63e5937500001029/63e5937500001221 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway false UniProtKB:Q9Y450 HBS1L Hsap 63e5937500001279 Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001279/63e5937500001280 GO:0003924 GTPase activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0022626 cytosolic ribosome false UniProtKB:Q9BRX2 PELO Hsap 63e5937500001279 Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001279/63e5937500001289 GO:0170011 stalled ribosome sensor activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0022626 cytosolic ribosome false UniProtKB:P61221 ABCE1 Hsap 63e5937500001279 Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001279/63e5937500001298 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false GO:0055087 Ski complex 63e5937500001279 Extraction of mRNA from stalled ribosomes by the SKI complex, leading to recruitment of the PELO-HBS1L complex that binds to stalled ribosomes, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001279/63e5937500001307 GO:0034458 3'-5' RNA helicase activity GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay GO:0022626 cytosolic ribosome false UniProtKB:P62495 ETF1 Hsap 63e5937500001319 Translation termination by the eRF1-eRF3 complex, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001319/63e5937500001320 GO:0008079 translation termination factor activity GO:0006415 translational termination GO:0022626 cytosolic ribosome false UniProtKB:P61221 ABCE1 Hsap 63e5937500001319 Translation termination by the eRF1-eRF3 complex, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001319/63e5937500001327 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:P15170 GSPT1 Hsap 63e5937500001319 Translation termination by the eRF1-eRF3 complex, followed by ribosome dissociation by ABCE1 (Human) NCBITaxon:9606 gomodel:63e5937500001319/63e5937500001336 GO:0003924 GTPase activity GO:0006415 translational termination GO:0022626 cytosolic ribosome false UniProtKB:Q8TF66 LRRC15 Hsap 63f809ec00000027 Trans-negative regulation of Sars-CoV-2 viral entry into host cell by LRRC15. (Human-Sars-CoV-2) NCBITaxon:9606 gomodel:63f809ec00000027/63f809ec00000028 GO:0140311 protein sequestering activity GO:0046597 host-mediated suppression of symbiont invasion GO:0016324 apical plasma membrane false UniProtKB:Q9BYF1 ACE2 Hsap 63f809ec00000027 Trans-negative regulation of Sars-CoV-2 viral entry into host cell by LRRC15. (Human-Sars-CoV-2) NCBITaxon:9606 gomodel:63f809ec00000027/63f809ec00000046 GO:0001618 virus receptor activity GO:0098670 entry receptor-mediated virion attachment to host cell GO:0005886 plasma membrane false UniProtKB:P0DTC2 S protein Scov2 63f809ec00000027 Trans-negative regulation of Sars-CoV-2 viral entry into host cell by LRRC15. (Human-Sars-CoV-2) NCBITaxon:9606 gomodel:63f809ec00000027/64b9cb1500000221 GO:0048018 receptor ligand activity GO:0098670 entry receptor-mediated virion attachment to host cell GO:0043655 host extracellular region false UniProtKB:P98177 FOXO4 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/63f809ec00000153 GO:0003700 DNA-binding transcription factor activity GO:0006979 response to oxidative stress GO:0005634 nucleus false UniProtKB:Q14258 TRIM25 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/63f809ec00000162 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0010494 cytoplasmic stress granule false UniProtKB:Q14145 KEAP1 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/63f809ec00000176 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q16236 NFE2L2 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/63f809ec00000186 GO:0003700 DNA-binding transcription factor activity GO:0034599 cellular response to oxidative stress GO:0005634 nucleus false UniProtKB:Q13618 CUL3 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/66b5638000000845 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 63f809ec00000152 TRIM25-mediated regulation of NRF2 signaling through activation by FOXO4 (Human) NCBITaxon:9606 gomodel:63f809ec00000152/66b5638000000857 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9H8W5 TRIM45 Hsap 63f809ec00000307 TRIM45-mediated degradation of TAB2 leading to inflammatory response inhibition (Human) NCBITaxon:9606 gomodel:63f809ec00000307/63f809ec00000308 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 63f809ec00000307 TRIM45-mediated degradation of TAB2 leading to inflammatory response inhibition (Human) NCBITaxon:9606 gomodel:63f809ec00000307/63f809ec00000319 GO:0060090 molecular adaptor activity GO:0006954 inflammatory response GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 63f809ec00000307 TRIM45-mediated degradation of TAB2 leading to inflammatory response inhibition (Human) NCBITaxon:9606 gomodel:63f809ec00000307/63f809ec00000329 GO:0004709 MAP kinase kinase kinase activity GO:0006954 inflammatory response GO:0005737 cytoplasm false UniProtKB:Q495X7 TRIM60 Hsap 63f809ec00000347 TRIM60-mediated inhibition of NF-kappa-B signaling via TAB2 SUMOylation (Human) NCBITaxon:9606 gomodel:63f809ec00000347/63f809ec00000348 GO:0140082 SUMO-ubiquitin ligase activity GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 63f809ec00000347 TRIM60-mediated inhibition of NF-kappa-B signaling via TAB2 SUMOylation (Human) NCBITaxon:9606 gomodel:63f809ec00000347/63f809ec00000357 GO:0060090 molecular adaptor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 63f809ec00000347 TRIM60-mediated inhibition of NF-kappa-B signaling via TAB2 SUMOylation (Human) NCBITaxon:9606 gomodel:63f809ec00000347/63f809ec00000365 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 63f809ec00000347 TRIM60-mediated inhibition of NF-kappa-B signaling via TAB2 SUMOylation (Human) NCBITaxon:9606 gomodel:63f809ec00000347/63f809ec00000379 GO:0004709 MAP kinase kinase kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O60524 NEMF Hsap 63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) NCBITaxon:9606 gomodel:63f809ec00000512/63f809ec00000513 GO:0043023 ribosomal large subunit binding GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:O60524 NEMF Hsap 63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) NCBITaxon:9606 gomodel:63f809ec00000512/63f809ec00000520 GO:1904678 alpha-aminoacyl-tRNA binding GO:0140708 CAT tailing GO:0022626 cytosolic ribosome false UniProtKB:O94822 LTN1 Hsap 63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) NCBITaxon:9606 gomodel:63f809ec00000512/63f809ec00000529 GO:0061630 ubiquitin protein ligase activity GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process GO:0022626 cytosolic ribosome false UniProtKB:P61221 ABCE1 Hsap 63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) NCBITaxon:9606 gomodel:63f809ec00000512/63f809ec00000540 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:Q8N3C0 ASCC3 Hsap 63f809ec00000512 Activity of the RQC complex via ubiquitination and degradation of incompletely synthesized nascent proteins (by NEMF and LTN1) following ribosome dissociation (Human) NCBITaxon:9606 gomodel:63f809ec00000512/63f809ec00000550 GO:0016887 ATP hydrolysis activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:O60524 NEMF Hsap 63f809ec00000560 Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000560/63f809ec00000561 GO:0043023 ribosomal large subunit binding GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:O60524 NEMF Hsap 63f809ec00000560 Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000560/63f809ec00000565 GO:1904678 alpha-aminoacyl-tRNA binding GO:0140708 CAT tailing GO:0022626 cytosolic ribosome false UniProtKB:P61221 ABCE1 Hsap 63f809ec00000560 Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000560/63f809ec00000575 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:Q8N3C0 ASCC3 Hsap 63f809ec00000560 Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000560/63f809ec00000580 GO:0016887 ATP hydrolysis activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:Q6PID8 KLHDC10 Hsap 63f809ec00000560 Non-canonical activity of the RQC complex via CAT-tailing by NEMF that promotes degradation of incompletely synthesized nascent proteins by the DesCEND pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000560/63f809ec00000601 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0005737 cytoplasm false UniProtKB:Q6PID8 KLHDC10 Hsap 63f809ec00000611 The CRL2(KLHDC10) complex catalyzes ubiquitination via the DesCEND (destruction via C-end degrons) pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000611/63f809ec00000612 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway false UniProtKB:Q13617 CUL2 Hsap 63f809ec00000611 The CRL2(KLHDC10) complex catalyzes ubiquitination via the DesCEND (destruction via C-end degrons) pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000611/63f809ec00000619 GO:0160072 ubiquitin ligase complex scaffold activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway false UniProtKB:P62877 RBX1 Hsap 63f809ec00000611 The CRL2(KLHDC10) complex catalyzes ubiquitination via the DesCEND (destruction via C-end degrons) pathway (Human) NCBITaxon:9606 gomodel:63f809ec00000611/63f809ec00000627 GO:0061630 ubiquitin protein ligase activity GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway false UniProtKB:O60524 NEMF Hsap 63f809ec00000701 tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human) NCBITaxon:9606 gomodel:63f809ec00000701/63f809ec00000706 GO:1904678 alpha-aminoacyl-tRNA binding GO:0140708 CAT tailing GO:0022626 cytosolic ribosome false UniProtKB:Q9H8Y5 ANKZF1 Hsap 63f809ec00000701 tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human) NCBITaxon:9606 gomodel:63f809ec00000701/63f809ec00000726 GO:0004521 RNA endonuclease activity GO:0072344 rescue of stalled cytosolic ribosome false UniProtKB:Q9H777 ELAC1 Hsap 63f809ec00000701 tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human) NCBITaxon:9606 gomodel:63f809ec00000701/63f809ec00000735 GO:0004549 tRNA-specific ribonuclease activity GO:0042780 tRNA 3'-end processing false UniProtKB:Q96Q11 TRNT1 Hsap 63f809ec00000701 tRNA repair and recycling by ANKZF1, ELAC1 and TRNT1 following activity of the RQC complex in response to stalled ribosomes (Human) NCBITaxon:9606 gomodel:63f809ec00000701/63f809ec00000742 GO:0004810 CCA tRNA nucleotidyltransferase activity GO:0001680 tRNA 3'-terminal CCA addition false UniProtKB:P67870 CSNK2B Hsap 63f809ec00001308 EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001308/63f809ec00001309 GO:0019887 protein kinase regulator activity GO:0075342 symbiont-mediated disruption of host cell PML body GO:0016605 PML body false UniProtKB:P68400 CSNK2A1 Hsap 63f809ec00001308 EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001308/63f809ec00001318 GO:0016301 kinase activity GO:0075342 symbiont-mediated disruption of host cell PML body GO:0016605 PML body false UniProtKB:P03211 EBNA1 NCBITaxon:10377 63f809ec00001308 EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001308/63f809ec00001328 GO:0140767 enzyme-substrate adaptor activity GO:0075342 symbiont-mediated disruption of host cell PML body GO:0075341 host cell PML body false UniProtKB:Q93009 USP7 Hsap 63f809ec00001308 EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001308/63f809ec00001340 GO:1990380 K48-linked deubiquitinase activity GO:0075342 symbiont-mediated disruption of host cell PML body GO:0016605 PML body false UniProtKB:P29590 PML Hsap 63f809ec00001308 EBNA1 hijacks the host kinase CK2 to disrupt PML nuclear bodies. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001308/63f809ec00001349 GO:0060090 molecular adaptor activity GO:0030578 PML body organization GO:0016605 PML body false UniProtKB:Q96B23 ARK2N Hsap 63f809ec00001358 ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001358/63f809ec00001359 GO:0003714 transcription corepressor activity GO:1903901 negative regulation of viral life cycle GO:0000785 chromatin false UniProtKB:P03206 BZLF1 NCBITaxon:10377 63f809ec00001358 ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001358/63f809ec00001362 GO:0003700 DNA-binding transcription factor activity GO:0019046 release from viral latency GO:0000785 chromatin false UniProtKB:P05412 JUN Hsap 63f809ec00001358 ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001358/63f809ec00001375 GO:0003700 DNA-binding transcription factor activity GO:0019046 release from viral latency GO:0000785 chromatin false UniProtKB:P67870 CSNK2B Hsap 63f809ec00001358 ARKL1 negatively negulates Epstein-Barr virus reactivation by inhibiting JUN-mediated transcription. (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:63f809ec00001358/63f809ec00001386 GO:0030674 protein-macromolecule adaptor activity GO:1903901 negative regulation of viral life cycle GO:0000785 chromatin false UniProtKB:P01137 TGFB1 Hsap 63f809ec00001734 TGF-beta-mediated inhibition of TAF7 via TRIM26 NCBITaxon:9606 gomodel:63f809ec00001734/63f809ec00001735 GO:0005125 cytokine activity GO:0060395 SMAD protein signal transduction GO:0005576 extracellular region false UniProtKB:P84022 SMAD3 Hsap 63f809ec00001734 TGF-beta-mediated inhibition of TAF7 via TRIM26 NCBITaxon:9606 gomodel:63f809ec00001734/63f809ec00001742 GO:0003700 DNA-binding transcription factor activity GO:0060395 SMAD protein signal transduction GO:0005634 nucleus false UniProtKB:Q12899 TRIM26 Hsap 63f809ec00001734 TGF-beta-mediated inhibition of TAF7 via TRIM26 NCBITaxon:9606 gomodel:63f809ec00001734/63f809ec00001749 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q15545 TAF7 Hsap 63f809ec00001734 TGF-beta-mediated inhibition of TAF7 via TRIM26 NCBITaxon:9606 gomodel:63f809ec00001734/63f809ec00001762 GO:0016251 RNA polymerase II general transcription initiation factor activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P01106 MYC Hsap 63f809ec00001734 TGF-beta-mediated inhibition of TAF7 via TRIM26 NCBITaxon:9606 gomodel:63f809ec00001734/63f809ec00001771 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0060633 negative regulation of transcription initiation by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q12899 TRIM26 Hsap 63f809ec00001892 TRIM26 activation of TAK1/MAP3K7 via TAB1-K11-linked ubiquitination (Human) NCBITaxon:9606 gomodel:63f809ec00001892/63f809ec00001893 GO:0061630 ubiquitin protein ligase activity GO:0070979 protein K11-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q15750 TAB1 Hsap 63f809ec00001892 TRIM26 activation of TAK1/MAP3K7 via TAB1-K11-linked ubiquitination (Human) NCBITaxon:9606 gomodel:63f809ec00001892/63f809ec00001900 GO:0060090 molecular adaptor activity GO:0038061 non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 63f809ec00001892 TRIM26 activation of TAK1/MAP3K7 via TAB1-K11-linked ubiquitination (Human) NCBITaxon:9606 gomodel:63f809ec00001892/63f809ec00001912 GO:0004707 MAP kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6413ac9800000138 p62/SQSTM1 inhibition of TLR4-mediated signaling via ECSIT (Human) NCBITaxon:9606 gomodel:6413ac9800000138/6413ac9800000139 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q13501 SQSTM1 Hsap 6413ac9800000138 p62/SQSTM1 inhibition of TLR4-mediated signaling via ECSIT (Human) NCBITaxon:9606 gomodel:6413ac9800000138/6413ac9800000150 GO:0140313 molecular sequestering activity GO:0034144 negative regulation of toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9BQ95 ECSIT Hsap 6413ac9800000138 p62/SQSTM1 inhibition of TLR4-mediated signaling via ECSIT (Human) NCBITaxon:9606 gomodel:6413ac9800000138/6413ac9800000160 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:O00206 TLR4 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000263 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99836 MYD88 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000266 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P58753 TIRAP Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000268 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9NWZ3 IRAK4 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000282 GO:0004674 protein serine/threonine kinase activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:O43187 IRAK2 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000288 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000293 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14457 BECN1 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000634 GO:0060090 molecular adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q8NEB9 PIK3C3 Hsap 6413ac9800000256 MYD88-dependent TLR4 signaling pathway leading to autophagy activation (Human) NCBITaxon:9606 gomodel:6413ac9800000256/6413ac9800000644 GO:0052742 phosphatidylinositol kinase activity GO:0000045 autophagosome assembly GO:0005737 cytoplasm false UniProtKB:O00206 TLR4 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000655 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q86XR7 TICAM2 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000659 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q8IUC6 TICAM1 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000703 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q13114 TRAF3 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000713 GO:0061630 ubiquitin protein ligase activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q9UHD2 TBK1 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000727 GO:0004674 protein serine/threonine kinase activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 6413ac9800000654 MYD88-independent TLR4 signaling pathway leading to interferon production (Human) NCBITaxon:9606 gomodel:6413ac9800000654/6413ac9800000737 GO:0003700 DNA-binding transcription factor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0000785 chromatin false UniProtKB:Q9HC29 NOD2 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000051 GO:0038187 pattern recognition receptor activity GO:0032495 response to muramyl dipeptide GO:0005886 plasma membrane false UniProtKB:Q9UJ70 NAGK Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000060 GO:0160047 muramyl dipeptide kinase activity GO:0032495 response to muramyl dipeptide false UniProtKB:P98170 XIAP Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000072 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q96EP0 RNF31 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000087 GO:0004842 ubiquitin-protein transferase activity GO:0097039 protein linear polyubiquitination GO:0005829 cytosol false UniProtKB:O43353 RIPK2 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000100 GO:0035591 signaling adaptor activity GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9Y6K9 IKBKG Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000116 GO:0031593 polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000126 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:Q8N5C8 TAB3 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000134 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000146 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000172 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000181 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000193 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000201 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:O43318 MAP3K7 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000688 GO:0004709 MAP kinase kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:P52564 MAP2K6 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000701 GO:0004708 MAP kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q15759 MAPK11 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000713 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q16539 MAPK14 Hsap 641ce4dc00000050 NOD2 signaling in response to muramyl dipeptide (MDP) leading to NF-kappa-B and MAPK kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000050/641ce4dc00000722 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q9Y239 NOD1 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000215 GO:0038187 pattern recognition receptor activity GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0005886 plasma membrane false UniProtKB:P98170 XIAP Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000226 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q96EP0 RNF31 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000234 GO:0004842 ubiquitin-protein transferase activity GO:0097039 protein linear polyubiquitination GO:0005829 cytosol false UniProtKB:O43353 RIPK2 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000241 GO:0035591 signaling adaptor activity GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9Y6K9 IKBKG Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000246 GO:0031593 polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000251 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:Q8N5C8 TAB3 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000255 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000261 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000267 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000271 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000277 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000281 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P52564 MAP2K6 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000645 GO:0004708 MAP kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:O43318 MAP3K7 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000652 GO:0004709 MAP kinase kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q16539 MAPK14 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000671 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q15759 MAPK11 Hsap 641ce4dc00000214 NOD1 signaling in response to gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) leading to NF-kappa-B and MAP kinase activation (Human) NCBITaxon:9606 gomodel:641ce4dc00000214/641ce4dc00000679 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q9C0B5 ZDHHC5 Hsap 641ce4dc00000430 NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human) NCBITaxon:9606 gomodel:641ce4dc00000430/641ce4dc00000431 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0072659 protein localization to plasma membrane GO:0005886 plasma membrane false UniProtKB:Q9HC29 NOD2 Hsap 641ce4dc00000430 NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human) NCBITaxon:9606 gomodel:641ce4dc00000430/641ce4dc00000446 GO:0038187 pattern recognition receptor activity GO:0032495 response to muramyl dipeptide GO:0005886 plasma membrane false UniProtKB:P98170 XIAP Hsap 641ce4dc00000430 NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human) NCBITaxon:9606 gomodel:641ce4dc00000430/641ce4dc00000461 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O43353 RIPK2 Hsap 641ce4dc00000430 NOD2 localization to the plasma membrane following palmitoylation by ZDHHC5 (Human) NCBITaxon:9606 gomodel:641ce4dc00000430/641ce4dc00000475 GO:0035591 signaling adaptor activity GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96S82 UBL7 Hsap 641ce4dc00000586 UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human) NCBITaxon:9606 gomodel:641ce4dc00000586/641ce4dc00000587 GO:0030674 protein-macromolecule adaptor activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P19474 TRIM21 Hsap 641ce4dc00000586 UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human) NCBITaxon:9606 gomodel:641ce4dc00000586/641ce4dc00000596 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 641ce4dc00000586 UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human) NCBITaxon:9606 gomodel:641ce4dc00000586/641ce4dc00000610 GO:0030674 protein-macromolecule adaptor activity GO:0140374 antiviral innate immune response GO:0005741 mitochondrial outer membrane false UniProtKB:Q01804 OTUD4 Hsap 641ce4dc00000586 UBL7/TRIM21-mediated ubiquitination of MAVS leading to type I interferon production (Human) NCBITaxon:9606 gomodel:641ce4dc00000586/641ce4dc00000620 GO:0004843 cysteine-type deubiquitinase activity GO:0035871 protein K11-linked deubiquitination GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00000961 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00000967 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00000971 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00000977 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00000981 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9UKB1 FBXW11 Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00001009 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00001021 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13616 CUL1 Hsap 641ce4dc00000914 Activation of Nf-kappa-B via ubiquitination and degradation of the NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00000914/641ce4dc00001035 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:O14920 IKBKB Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001054 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001058 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001064 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001068 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q5XPI4 RNF123 Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001093 GO:0061630 ubiquitin protein ligase activity GO:0000209 protein polyubiquitination GO:0005737 cytoplasm false UniProtKB:O14920 IKBKB Hsap 641ce4dc00001047 Generation of NFKB1 p50 subunit of NF-kappa-B via limited processing by the KPC1 complex (RNF123), leading to NF-kappa-B inhibitor (Human) NCBITaxon:9606 gomodel:641ce4dc00001047/641ce4dc00001104 GO:0004674 protein serine/threonine kinase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:Q92985 IRF7 Hsap 6438950a00000032 Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000032/6438950a00000033 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0032728 positive regulation of interferon-beta production GO:0000785 chromatin false UniProtKB:Q9UHD2 TBK1 Hsap 6438950a00000032 Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000032/6438950a00000040 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q9NR96 TLR9 Hsap 6438950a00000032 Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000032/6438950a00000052 GO:0038187 pattern recognition receptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0005783 endoplasmic reticulum false UniProtKB:Q6WB96 M2 NCBITaxon:694067 6438950a00000032 Human metapneumovirus M2-2 inhibition of IRF7 (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000032/6438950a00000064 GO:0140311 protein sequestering activity GO:0032480 negative regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:O95786 RIGI Hsap 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000080 GO:0038187 pattern recognition receptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14258 TRIM25 Hsap 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000084 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000089 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0031966 mitochondrial membrane false UniProtKB:Q6WB96 M2 NCBITaxon:694067 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000104 GO:0140311 protein sequestering activity GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q6WB96 M2 NCBITaxon:694067 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000114 GO:0140311 protein sequestering activity GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6438950a00000074 Human metapneumovirus M2-2 inhibition of RIGI-MAVS signaling (Human-Metapneumovirus) NCBITaxon:9606 gomodel:6438950a00000074/6438950a00000493 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9H4A3 WNK1 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000625 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:Q9H4A3 WNK1 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000636 GO:0004674 protein serine/threonine kinase activity GO:0006884 cell volume homeostasis GO:0005737 cytoplasm false UniProtKB:O95747 OXSR1 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000650 GO:0004674 protein serine/threonine kinase activity GO:0006884 cell volume homeostasis GO:0005737 cytoplasm false UniProtKB:Q9UEW8 STK39 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000665 GO:0004674 protein serine/threonine kinase activity GO:0006884 cell volume homeostasis GO:0005737 cytoplasm false UniProtKB:Q13621 SLC12A1 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000684 GO:0008511 sodium:potassium:chloride symporter activity GO:0006884 cell volume homeostasis GO:0016324 apical plasma membrane false UniProtKB:P55011 SLC12A2 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000691 GO:0008511 sodium:potassium:chloride symporter activity GO:0006884 cell volume homeostasis GO:0016323 basolateral plasma membrane false UniProtKB:Q9UHW9 SLC12A6 Hsap 6438950a00000624 Activation of the WNK1-SPAK/OSR1 kinase cascade in response to hyperosmotic stress, leading to promote ion influx and prevent ion efflux (Human) NCBITaxon:9606 gomodel:6438950a00000624/6438950a00000702 GO:0015379 potassium:chloride symporter activity GO:0071805 potassium ion transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q96J92 WNK4 Hsap 6438950a00000714 Regulation of ion transport in the distal nephron by WNK4 (Human) NCBITaxon:9606 gomodel:6438950a00000714/6438950a00000715 GO:0004674 protein serine/threonine kinase activity GO:0070294 renal sodium ion absorption GO:0005923 bicellular tight junction false UniProtKB:O95747 OXSR1 Hsap 6438950a00000714 Regulation of ion transport in the distal nephron by WNK4 (Human) NCBITaxon:9606 gomodel:6438950a00000714/6438950a00000729 GO:0004674 protein serine/threonine kinase activity GO:0070294 renal sodium ion absorption GO:0005737 cytoplasm false UniProtKB:Q9UEW8 STK39 Hsap 6438950a00000714 Regulation of ion transport in the distal nephron by WNK4 (Human) NCBITaxon:9606 gomodel:6438950a00000714/6438950a00000740 GO:0004674 protein serine/threonine kinase activity GO:0070294 renal sodium ion absorption GO:0005737 cytoplasm false UniProtKB:P55017 SLC12A3 Hsap 6438950a00000714 Regulation of ion transport in the distal nephron by WNK4 (Human) NCBITaxon:9606 gomodel:6438950a00000714/6438950a00000754 GO:0015378 sodium:chloride symporter activity GO:0070294 renal sodium ion absorption GO:0005886 plasma membrane false UniProtKB:Q9UH77 KLHL3 Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000767 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005829 cytosol false UniProtKB:Q96J92 WNK4 Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000780 GO:0004674 protein serine/threonine kinase activity GO:0070294 renal sodium ion absorption GO:0005923 bicellular tight junction false UniProtKB:Q13618 CUL3 Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000795 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000805 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P17252 PRKCA Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000816 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0110063 positive regulation of angiotensin-activated signaling pathway GO:0005737 cytoplasm false UniProtKB:P01019 AGT Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000826 GO:0005179 hormone activity GO:0038166 angiotensin-activated signaling pathway GO:0005576 extracellular region false UniProtKB:Q08209 PPP3CA Hsap 6438950a00000766 Ubiquitination of WNK4 in the distal nephron by KLHL3 and its regulation by phosphorylation and dephosphorylation (Human) NCBITaxon:9606 gomodel:6438950a00000766/6438950a00000834 GO:0033192 calmodulin-dependent protein phosphatase activity GO:0110062 negative regulation of angiotensin-activated signaling pathway GO:0005737 cytoplasm false UniProtKB:O75385 ULK1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/6446bfcb00001775 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:O75143 ATG13 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/6446bfcb00001782 GO:0019209 kinase activator activity GO:0000045 autophagosome assembly GO:0034045 phagophore assembly site membrane false UniProtKB:Q8TDY2-1 RB1CC1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/6446bfcb00001805 GO:0043495 protein-membrane adaptor activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q9C0C7 AMBRA1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001734 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0000045 autophagosome assembly GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001755 GO:0061630 ubiquitin protein ligase activity GO:0000045 autophagosome assembly false UniProtKB:P42345 MTOR Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001763 GO:0004674 protein serine/threonine kinase activity GO:2000785 regulation of autophagosome assembly false UniProtKB:Q14457 BECN1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001770 GO:0030674 protein-macromolecule adaptor activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q8NEB9 PIK3C3 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001775 GO:0016303 1-phosphatidylinositol-3-kinase activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q6ZNE5 ATG14 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001820 GO:0043495 protein-membrane adaptor activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q676U5 ATG16L1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001907 GO:0043495 protein-membrane adaptor activity GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9H1Y0 ATG5 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001915 GO:0019776 Atg8-family ligase activity GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q9H0Y0 ATG10 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001922 GO:0061651 Atg12 conjugating enzyme activity GO:0000045 autophagosome assembly false UniProtKB:O95352 ATG7 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001924 GO:0019778 Atg12 activating enzyme activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:O95352 ATG7 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/645d887900001926 GO:0019779 Atg8 activating enzyme activity GO:0000407 phagophore assembly site false UniProtKB:Q9H492 MAP1LC3A Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000268 GO:0005543 phospholipid binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9GZQ8 MAP1LC3B Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000276 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9BXW4 MAP1LC3C Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000279 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:O95166 GABARAP Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000286 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9H0R8 GABARAPL1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000291 GO:0005543 phospholipid binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:P60520 GABARAPL2 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000296 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9NT62 ATG3 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000301 GO:0141046 Atg8-family conjugating enzyme activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q8WYN0 ATG4A Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000311 GO:0008234 cysteine-type peptidase activity GO:0000045 autophagosome assembly false UniProtKB:Q9Y4P1 ATG4B Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000381 GO:0004197 cysteine-type endopeptidase activity GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q96DT6 ATG4C Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000384 GO:0004197 cysteine-type endopeptidase activity GO:0000045 autophagosome assembly false UniProtKB:Q86TL0-2 ATG4D Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100000387 GO:0070004 cysteine-type exopeptidase activity GO:0000045 autophagosome assembly false UniProtKB:Q5MNZ9 WIPI1 Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100002442 GO:0030674 protein-macromolecule adaptor activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q2TAZ0-5 ATG2A Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100002450 GO:0120013 lipid transfer activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q96BY7 ATG2B Hsap 6446bfcb00001774 Autophagosome assembly (Human) NCBITaxon:9606 gomodel:6446bfcb00001774/646ff70100002458 GO:0120013 lipid transfer activity GO:0000045 autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q5T848 GPR158 Hsap 645d887900000245 Glycine-binding to metabotropic glycine receptor GPR158 leads to inhibition of the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000245/645d887900000246 GO:0160079 G protein-coupled glycine receptor activity GO:0008277 regulation of G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P49802 RGS7 Hsap 645d887900000245 Glycine-binding to metabotropic glycine receptor GPR158 leads to inhibition of the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000245/645d887900000255 GO:0005096 GTPase activator activity GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P09471 GNAO1 Hsap 645d887900000245 Glycine-binding to metabotropic glycine receptor GPR158 leads to inhibition of the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000245/645d887900000265 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q5T848 GPR158 Hsap 645d887900000271 In absence of glycine, the metabotropic glycine receptor GPR158 activates the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000271/645d887900000272 GO:0008047 enzyme activator activity GO:0008277 regulation of G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P49802 RGS7 Hsap 645d887900000271 In absence of glycine, the metabotropic glycine receptor GPR158 activates the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000271/645d887900000277 GO:0005096 GTPase activator activity GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P09471 GNAO1 Hsap 645d887900000271 In absence of glycine, the metabotropic glycine receptor GPR158 activates the GTPase activator activity of RGS7 (Human). NCBITaxon:9606 gomodel:645d887900000271/645d887900000282 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P02818 BGLAP Hsap 645d887900000758 Osteocalcin (BGLAP) hormone produced by osteoblasts binds GPR158 receptor and regulates brain development (Human). NCBITaxon:9606 gomodel:645d887900000758/645d887900000759 GO:0005179 hormone activity GO:0007420 brain development GO:0005576 extracellular region false UniProtKB:P38435 GGCX Hsap 645d887900000758 Osteocalcin (BGLAP) hormone produced by osteoblasts binds GPR158 receptor and regulates brain development (Human). NCBITaxon:9606 gomodel:645d887900000758/645d887900000763 GO:0008488 gamma-glutamyl carboxylase activity GO:0046929 negative regulation of neurotransmitter secretion false UniProtKB:Q5T848 GPR158 Hsap 645d887900000758 Osteocalcin (BGLAP) hormone produced by osteoblasts binds GPR158 receptor and regulates brain development (Human). NCBITaxon:9606 gomodel:645d887900000758/645d887900000766 GO:0004888 transmembrane signaling receptor activity GO:0007420 brain development GO:0005886 plasma membrane false UniProtKB:P18075 BMP7 Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/645d887900001000 GO:0008083 growth factor activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:Q99717 SMAD5 Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/645d887900001027 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0000785 chromatin false UniProtKB:Q04771 ACVR1 Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/66e382fb00001905 GO:0016361 activin receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/66e382fb00002012 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/66e382fb00002029 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:P27037 ACVR2A Hsap 645d887900000999 BMP7 signaling leading to osteoblast differentiation (Human) NCBITaxon:9606 gomodel:645d887900000999/66e382fb00002043 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:P62258 YWHAE Hsap 645d887900001323 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) NCBITaxon:9606 gomodel:645d887900001323/645d887900001330 GO:0140311 protein sequestering activity GO:0030007 intracellular potassium ion homeostasis GO:0005737 cytoplasm false UniProtKB:Q8NHG8 ZNRF2 Hsap 645d887900001323 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) NCBITaxon:9606 gomodel:645d887900001323/645d887900001339 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043231 intracellular membrane-bounded organelle false UniProtKB:P05023 ATP1A1 Hsap 645d887900001323 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) NCBITaxon:9606 gomodel:645d887900001323/645d887900001352 GO:0016887 ATP hydrolysis activity GO:0030007 intracellular potassium ion homeostasis GO:0005886 plasma membrane false UniProtKB:P17612 PRKACA Hsap 645d887900001323 14-3-3 sequestering of ZNRF2 E3 ligase leading to ATP1A1 activity at plasma membrane (Human) NCBITaxon:9606 gomodel:645d887900001323/645d887900001390 GO:0106310 protein serine kinase activity GO:0030007 intracellular potassium ion homeostasis GO:0005737 cytoplasm false UniProtKB:Q03135 CAV1 Hsap 645d887900001414 ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) NCBITaxon:9606 gomodel:645d887900001414/645d887900001415 GO:0140311 protein sequestering activity GO:0034144 negative regulation of toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8ND25 ZNRF1 Hsap 645d887900001414 ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) NCBITaxon:9606 gomodel:645d887900001414/645d887900001424 GO:0061630 ubiquitin protein ligase activity GO:0034145 positive regulation of toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:O00206 TLR4 Hsap 645d887900001414 ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) NCBITaxon:9606 gomodel:645d887900001414/645d887900001434 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P27986 PIK3R1 Hsap 645d887900001414 ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) NCBITaxon:9606 gomodel:645d887900001414/645d887900001442 GO:0052742 phosphatidylinositol kinase activity GO:0034143 regulation of toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q99836 MYD88 Hsap 645d887900001414 ZNFR1-mediated TLR4 signaling pathway via CAV1 ubiquitination and degradation (Human) NCBITaxon:9606 gomodel:645d887900001414/645d887900001447 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:O15455 TLR3 Hsap 645d887900001502 Src-ZNRF1 axis controls TLR3 trafficking (Human) NCBITaxon:9606 gomodel:645d887900001502/645d887900001503 GO:0038187 pattern recognition receptor activity GO:0034138 toll-like receptor 3 signaling pathway GO:0010008 endosome membrane false UniProtKB:P12931 SRC Hsap 645d887900001502 Src-ZNRF1 axis controls TLR3 trafficking (Human) NCBITaxon:9606 gomodel:645d887900001502/645d887900001510 GO:0004713 protein tyrosine kinase activity GO:0034139 regulation of toll-like receptor 3 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q8ND25 ZNRF1 Hsap 645d887900001502 Src-ZNRF1 axis controls TLR3 trafficking (Human) NCBITaxon:9606 gomodel:645d887900001502/645d887900001515 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8IUC6 TICAM1 Hsap 645d887900001502 Src-ZNRF1 axis controls TLR3 trafficking (Human) NCBITaxon:9606 gomodel:645d887900001502/645d887900001538 GO:0060090 molecular adaptor activity GO:0034138 toll-like receptor 3 signaling pathway GO:0010008 endosome membrane false UniProtKB:P12643 BMP2 Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/645d887900001796 GO:0008083 growth factor activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:P36894 BMPR1A Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/645d887900001803 GO:0005025 transforming growth factor beta receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q13873 BMPR2 Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/645d887900001811 GO:0005024 transforming growth factor beta receptor activity GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/646ff70100002376 GO:0003700 DNA-binding transcription factor activity GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q99717 SMAD5 Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/646ff70100002384 GO:0003700 DNA-binding transcription factor activity GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 645d887900001795 BMP2 signaling pathway (Human) NCBITaxon:9606 gomodel:645d887900001795/646ff70100002392 GO:0003700 DNA-binding transcription factor activity GO:0030509 BMP signaling pathway GO:0005634 nucleus false ComplexPortal:CPX-892 tlr2_tlr6_human Hsap 646ff70100000049 Antibacterial innate immune response to muramyl dipeptide. (Human) NCBITaxon:9606 gomodel:646ff70100000049/646ff70100000050 GO:0004888 transmembrane signaling receptor activity GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q16348 SLC15A2 Hsap 646ff70100000049 Antibacterial innate immune response to muramyl dipeptide. (Human) NCBITaxon:9606 gomodel:646ff70100000049/646ff70100000067 GO:0015333 peptide:proton symporter activity GO:0140367 antibacterial innate immune response GO:0030670 phagocytic vesicle membrane false UniProtKB:Q9HC29 NOD2 Hsap 646ff70100000049 Antibacterial innate immune response to muramyl dipeptide. (Human) NCBITaxon:9606 gomodel:646ff70100000049/646ff70100000083 GO:0038187 pattern recognition receptor activity GO:0071225 cellular response to muramyl dipeptide GO:0005829 cytosol false UniProtKB:P19838 NFKB1 Hsap 646ff70100000049 Antibacterial innate immune response to muramyl dipeptide. (Human) NCBITaxon:9606 gomodel:646ff70100000049/646ff70100000093 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:Q6PF18 MORN3 Hsap 646ff70100000239 Negative regulation of signal transduction by p53 class mediator by MORN3. (Human) NCBITaxon:9606 gomodel:646ff70100000239/646ff70100000240 GO:0030674 protein-macromolecule adaptor activity GO:1901797 negative regulation of signal transduction by p53 class mediator false UniProtKB:Q00987 MDM2 Hsap 646ff70100000239 Negative regulation of signal transduction by p53 class mediator by MORN3. (Human) NCBITaxon:9606 gomodel:646ff70100000239/646ff70100000245 GO:0061630 ubiquitin protein ligase activity GO:1901797 negative regulation of signal transduction by p53 class mediator false UniProtKB:Q96EB6 SIRT1 Hsap 646ff70100000239 Negative regulation of signal transduction by p53 class mediator by MORN3. (Human) NCBITaxon:9606 gomodel:646ff70100000239/646ff70100000253 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:1901797 negative regulation of signal transduction by p53 class mediator false UniProtKB:P04637 TP53 Hsap 646ff70100000239 Negative regulation of signal transduction by p53 class mediator by MORN3. (Human) NCBITaxon:9606 gomodel:646ff70100000239/646ff70100000261 GO:0003700 DNA-binding transcription factor activity GO:0072331 signal transduction by p53 class mediator false GO:0071986 Ragulator complex 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000392 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000402 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000417 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000427 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000443 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000463 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000478 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000496 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000509 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000522 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000530 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000545 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000554 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100000562 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q8N122 RPTOR Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100002533 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100000391 Canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000391/646ff70100002545 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100000611 Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000611/646ff70100000643 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100000611 Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000611/646ff70100000669 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q8N8N0 RNF152 Hsap 646ff70100000611 Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000611/646ff70100000811 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005765 lysosomal membrane false GO:1990130 GATOR1 complex 646ff70100000611 Ubiquitination of RagA/RRAGA by RNF152 inhibits the mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100000611/646ff70100000825 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100000838 N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human) NCBITaxon:9606 gomodel:646ff70100000838/646ff70100000849 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100000838 N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human) NCBITaxon:9606 gomodel:646ff70100000838/646ff70100000860 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:P30419 NMT1 Hsap 646ff70100000838 N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human) NCBITaxon:9606 gomodel:646ff70100000838/646ff70100001038 GO:0018030 peptidyl-lysine N6-myristoyltransferase activity GO:0072657 protein localization to membrane false UniProtKB:Q9NYG2 ZDHHC3 Hsap 646ff70100000838 N-terminal myristoylation and palmitoylation of LAMTOR1 mediates its recruitment to lysosome membranes (Human) NCBITaxon:9606 gomodel:646ff70100000838/646ff70100001047 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0072657 protein localization to membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001344 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001357 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001370 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001385 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001398 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001411 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001424 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001431 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001446 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001455 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001463 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false GO:0140007 KICSTOR complex 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001512 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q8WTW4 NPRL2 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001523 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 646ff70100001312 Inhibition of the canonical mTORC1 signaling by the GATOR1 complex (Human) NCBITaxon:9606 gomodel:646ff70100001312/646ff70100001542 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100001561 Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) NCBITaxon:9606 gomodel:646ff70100001561/646ff70100001571 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 646ff70100001561 Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) NCBITaxon:9606 gomodel:646ff70100001561/646ff70100001735 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q53GT1 KLHL22 Hsap 646ff70100001561 Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) NCBITaxon:9606 gomodel:646ff70100001561/646ff70100001754 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005764 lysosome false UniProtKB:Q13618 CUL3 Hsap 646ff70100001561 Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) NCBITaxon:9606 gomodel:646ff70100001561/646ff70100001765 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 646ff70100001561 Activation of the mTORC1 signaling by ubiquitination and degradation of GATOR1 subunit DEPDC5 by KLHL22 (Human) NCBITaxon:9606 gomodel:646ff70100001561/646ff70100001773 GO:0031625 ubiquitin protein ligase binding GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100001795 Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human) NCBITaxon:9606 gomodel:646ff70100001795/646ff70100001796 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 646ff70100001795 Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human) NCBITaxon:9606 gomodel:646ff70100001795/646ff70100001807 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P11309 PIM1 Hsap 646ff70100001795 Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human) NCBITaxon:9606 gomodel:646ff70100001795/646ff70100001861 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P31749 AKT1 Hsap 646ff70100001795 Activation of the mTORC1 signaling by phosphorylation of GATOR1 subunit DEPDC5 by AKT1 and PIM1 (Human) NCBITaxon:9606 gomodel:646ff70100001795/646ff70100001869 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false GO:0071986 Ragulator complex 646ff70100001877 Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human) NCBITaxon:9606 gomodel:646ff70100001877/646ff70100001878 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100001877 Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human) NCBITaxon:9606 gomodel:646ff70100001877/646ff70100001888 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100001877 Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human) NCBITaxon:9606 gomodel:646ff70100001877/646ff70100001899 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q05086 UBE3A Hsap 646ff70100001877 Inhibition of the canonical mTORC1 signaling via ubiquitination and degradation of LAMTOR1 by UBE3A (Human) NCBITaxon:9606 gomodel:646ff70100001877/646ff70100002077 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false GO:0071986 Ragulator complex 646ff70100002094 Negative regulation of the canonical mTORC1 signaling via phosphorylation of LAMTOR4 by PKA (Human) NCBITaxon:9606 gomodel:646ff70100002094/646ff70100002095 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100002094 Negative regulation of the canonical mTORC1 signaling via phosphorylation of LAMTOR4 by PKA (Human) NCBITaxon:9606 gomodel:646ff70100002094/646ff70100002139 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false GO:0005952 cAMP-dependent protein kinase complex 646ff70100002094 Negative regulation of the canonical mTORC1 signaling via phosphorylation of LAMTOR4 by PKA (Human) NCBITaxon:9606 gomodel:646ff70100002094/646ff70100002298 GO:0106310 protein serine kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P12644 BMP4 Hsap 646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002308/646ff70100002309 GO:0005125 cytokine activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:Q99873 PRMT1 Hsap 646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002308/646ff70100002317 GO:0016274 protein-arginine N-methyltransferase activity GO:0030510 regulation of BMP signaling pathway GO:0005737 cytoplasm false UniProtKB:O43541 SMAD6 Hsap 646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002308/646ff70100002327 GO:0140311 protein sequestering activity GO:0030514 negative regulation of BMP signaling pathway GO:0005737 cytoplasm false UniProtKB:Q15797 SMAD1 Hsap 646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002308/646ff70100002345 GO:0003700 DNA-binding transcription factor activity GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q13485 SMAD4 Hsap 646ff70100002308 SMAD6 arginine methylation inhibits SMAD1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002308/646ff70100002352 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false GO:0071986 Ragulator complex 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002558 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002568 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q6IAA8 LAMTOR1 Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002579 GO:0043495 protein-membrane adaptor activity GO:0150032 positive regulation of protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002589 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002602 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002615 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002630 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002643 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002676 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002769 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 646ff70100002557 Negative regulation of autophagy via phosphorylation of ULK1 by canonical mTORC1 signaling (Human) NCBITaxon:9606 gomodel:646ff70100002557/646ff70100002785 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:P42345 MTOR Hsap 646ff70100002802 Positive regulation of canonical mTORC1 signaling via acetylation of RPTOR by EP300 (Human) NCBITaxon:9606 gomodel:646ff70100002802/646ff70100002901 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100002802 Positive regulation of canonical mTORC1 signaling via acetylation of RPTOR by EP300 (Human) NCBITaxon:9606 gomodel:646ff70100002802/646ff70100002947 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 646ff70100002802 Positive regulation of canonical mTORC1 signaling via acetylation of RPTOR by EP300 (Human) NCBITaxon:9606 gomodel:646ff70100002802/646ff70100002963 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q09472 EP300 Hsap 646ff70100002802 Positive regulation of canonical mTORC1 signaling via acetylation of RPTOR by EP300 (Human) NCBITaxon:9606 gomodel:646ff70100002802/646ff70100002978 GO:0061733 protein-lysine-acetyltransferase activity GO:0010507 negative regulation of autophagy false UniProtKB:Q7L523 RRAGA Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003183 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003198 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003211 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003224 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003325 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9UBE8 NLK Hsap 646ff70100003125 Inhibition of the canonical mTORC1 signaling by NLK in response to osmotic stress (Human) NCBITaxon:9606 gomodel:646ff70100003125/646ff70100003349 GO:0004674 protein serine/threonine kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 646ff70100003362 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) NCBITaxon:9606 gomodel:646ff70100003362/646ff70100003383 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100003362 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) NCBITaxon:9606 gomodel:646ff70100003362/646ff70100003396 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100003362 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) NCBITaxon:9606 gomodel:646ff70100003362/646ff70100003417 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P17612 PRKACA Hsap 646ff70100003362 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) NCBITaxon:9606 gomodel:646ff70100003362/646ff70100003440 GO:0004691 cAMP-dependent protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P22694 PRKACB Hsap 646ff70100003362 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by PKA (PRKACA and PRKACB) (Human) NCBITaxon:9606 gomodel:646ff70100003362/646ff70100003448 GO:0004691 cAMP-dependent protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 646ff70100003456 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003456/646ff70100003457 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100003456 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003456/646ff70100003468 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100003456 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003456/646ff70100003479 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9UHD2 TBK1 Hsap 646ff70100003456 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003456/646ff70100003507 GO:0004674 protein serine/threonine kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003602 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003635 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003650 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003659 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003667 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q9UHD2 TBK1 Hsap 646ff70100003516 Activation of mTORC1 signaling following phosphorylation of MTOR by TBK1 (Human) NCBITaxon:9606 gomodel:646ff70100003516/646ff70100003740 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004037 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004048 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q96FW1 OTUB1 Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004069 GO:0055105 ubiquitin-protein transferase inhibitor activity GO:0016579 protein deubiquitination false UniProtKB:Q9H3Y6 SRMS Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004082 GO:0004713 protein tyrosine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P12931 SRC Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004089 GO:0004713 protein tyrosine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P51668 UBE2D1 Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004098 GO:0061631 ubiquitin conjugating enzyme activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q96B02 UBE2W Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004112 GO:0061631 ubiquitin conjugating enzyme activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P61088 UBE2N Hsap 646ff70100004025 Activation of the canonical mTORC1 signaling via non-catalytic deubiquitination of RPTOR by OTUB1 (Human) NCBITaxon:9606 gomodel:646ff70100004025/646ff70100004129 GO:0061631 ubiquitin conjugating enzyme activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P61769 B2M Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004145 GO:0005198 structural molecule activity GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005783 endoplasmic reticulum false UniProtKB:P04439 HLA-A Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004151 GO:0042605 peptide antigen binding GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005783 endoplasmic reticulum false UniProtKB:Q03518 TAP1 Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004158 GO:1904680 peptide transmembrane transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q03519 TAP2 Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004166 GO:1904680 peptide transmembrane transporter activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005789 endoplasmic reticulum membrane false UniProtKB:P27797 CALR Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004174 GO:0030674 protein-macromolecule adaptor activity GO:0005783 endoplasmic reticulum false UniProtKB:P30101 PDIA3 Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004181 GO:0044183 protein folding chaperone GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005783 endoplasmic reticulum false UniProtKB:O15533 TAPBP Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004188 GO:0044183 protein folding chaperone GO:0002502 peptide antigen assembly with MHC class I protein complex GO:0005783 endoplasmic reticulum false UniProtKB:Q9NZ08 ERAP1 Hsap 646ff70100004144 Major histocompatibility complex class I (MHC I) peptide loading (Human) NCBITaxon:9606 gomodel:646ff70100004144/646ff70100004196 GO:0004177 aminopeptidase activity GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0005788 endoplasmic reticulum lumen false UniProtKB:P42345 MTOR Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004319 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004332 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004339 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004354 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004363 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004371 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q96B36 AKT1S1 Hsap 646ff70100004220 Inhibition of the canonical mTORC1 signaling by AKT1S1/PRAS40 in absence of insulin (Human) NCBITaxon:9606 gomodel:646ff70100004220/646ff70100004444 GO:0030291 protein serine/threonine kinase inhibitor activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004458 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004469 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004476 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004489 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004498 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004506 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q96B36 AKT1S1 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004523 GO:0030291 protein serine/threonine kinase inhibitor activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004536 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P31749 AKT1 Hsap 646ff70100004457 Phosphorylation of AKT1S1/PRAS40 in response to insulin, relieving AKT1S1/PRAS40 inhibitor activity (Human) NCBITaxon:9606 gomodel:646ff70100004457/646ff70100004547 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004692 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004705 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004718 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004725 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004740 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004749 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004757 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P49815 TSC2 Hsap 646ff70100004606 Inhibition of the canonical mTORC1 signaling by TSC2 in response to starvation (Human) NCBITaxon:9606 gomodel:646ff70100004606/646ff70100004830 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004849 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004860 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004873 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004880 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004895 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004904 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004912 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P49815 TSC2 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004931 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P31749 AKT1 Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004949 GO:0004674 protein serine/threonine kinase activity GO:0150033 negative regulation of protein localization to lysosome GO:0016020 membrane false UniProtKB:P42336 PIK3CA Hsap 646ff70100004848 Activation of the canonical mTORC1 signaling in response to insulin via phosphorylation and inhibition of TSC2 (Human) NCBITaxon:9606 gomodel:646ff70100004848/646ff70100004963 GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:1905477 positive regulation of protein localization to membrane false UniProtKB:Q96MN2 NLRP4 Hsap 646ff70100004973 USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) NCBITaxon:9606 gomodel:646ff70100004973/646ff70100004974 GO:0060090 molecular adaptor activity GO:0045824 negative regulation of innate immune response GO:0005737 cytoplasm false UniProtKB:Q8NB14 USP38 Hsap 646ff70100004973 USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) NCBITaxon:9606 gomodel:646ff70100004973/646ff70100004985 GO:0004843 cysteine-type deubiquitinase activity GO:1990168 protein K33-linked deubiquitination GO:0005737 cytoplasm false UniProtKB:Q96MN2 NLRP4 Hsap 646ff70100004973 USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) NCBITaxon:9606 gomodel:646ff70100004973/646ff70100004995 GO:0060090 molecular adaptor activity GO:0045824 negative regulation of innate immune response GO:0005737 cytoplasm false UniProtKB:Q9Y2E6 DTX4 Hsap 646ff70100004973 USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) NCBITaxon:9606 gomodel:646ff70100004973/646ff70100005008 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 646ff70100004973 USP38 Lys-33 to Lys-48 transition on TBK1 leading to its degratdation (Human) NCBITaxon:9606 gomodel:646ff70100004973/646ff70100005018 GO:0004674 protein serine/threonine kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:F5HGQ8 UL138 HCMVM 646ff70100005032 HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) NCBITaxon:9606 gomodel:646ff70100005032/646ff70100005076 GO:0060090 molecular adaptor activity GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO:0044178 host cell Golgi membrane false UniProtKB:Q8TAF3 WDR48 Hsap 646ff70100005032 HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) NCBITaxon:9606 gomodel:646ff70100005032/6482692800002469 GO:0035800 deubiquitinase activator activity GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO:0005737 cytoplasm false UniProtKB:O94782 USP1 Hsap 646ff70100005032 HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) NCBITaxon:9606 gomodel:646ff70100005032/6482692800002477 GO:0004843 cysteine-type deubiquitinase activity GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P42224 STAT1 Hsap 646ff70100005032 HCMV UL138 substains STAT1 activation during viral latency (Human-Cytomegalovirus) NCBITaxon:9606 gomodel:646ff70100005032/6482692800002485 GO:0003700 DNA-binding transcription factor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P49841 GSK3B Hsap 646ff70100005033 Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) NCBITaxon:9606 gomodel:646ff70100005033/646ff70100005034 GO:0004674 protein serine/threonine kinase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q969H0-1 FBXW7 Hsap 646ff70100005033 Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) NCBITaxon:9606 gomodel:646ff70100005033/646ff70100005044 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 646ff70100005033 Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) NCBITaxon:9606 gomodel:646ff70100005033/646ff70100005059 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P01106 MYC Hsap 646ff70100005033 Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) NCBITaxon:9606 gomodel:646ff70100005033/646ff70100005067 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000082 G1/S transition of mitotic cell cycle GO:0005634 nucleus false UniProtKB:Q8NB14 USP38 Hsap 646ff70100005033 Inhibition of FBXW7 by USP38 to prevent MYC degradation (Human) NCBITaxon:9606 gomodel:646ff70100005033/646ff70100005083 GO:0004843 cysteine-type deubiquitinase activity GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:O95760 IL33 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/646ff70100005138 GO:0005125 cytokine activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q01638 IL1RL1 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/646ff70100005145 GO:0004896 cytokine receptor activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9NPH3 IL1RAP Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/646ff70100005153 GO:0015026 coreceptor activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99836 MYD88 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/646ff70100005211 GO:0060090 molecular adaptor activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9NWZ3 IRAK4 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/6494e2e900000094 GO:0004674 protein serine/threonine kinase activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P51617 IRAK1 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/6494e2e900000104 GO:0004674 protein serine/threonine kinase activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/6494e2e900000116 GO:0061630 ubiquitin protein ligase activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 646ff70100005137 IL33-signaling pathway (Human) NCBITaxon:9606 gomodel:646ff70100005137/6494e2e900000126 GO:0004707 MAP kinase activity GO:0038172 interleukin-33-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q15382 RHEB Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000199 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000210 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000223 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000230 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000245 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000254 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000262 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P49815 TSC2 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000281 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N8N0 RNF152 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000299 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination false UniProtKB:Q13107 USP4 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000310 GO:0004843 cysteine-type deubiquitinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P31749 AKT1 Hsap 6482692800000198 Regulation of the canonical mTORC1 signaling via ubiquitination and deubiquitination of RHEB by RNF152 and USP4, respectively (Human) NCBITaxon:9606 gomodel:6482692800000198/6482692800000317 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000331 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000342 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000355 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000362 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000377 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000386 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000394 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P49815 TSC2 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000413 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P54252 ATXN3 Hsap 6482692800000330 Regulation of the canonical mTORC1 signaling via deubiquitination of RHEB by ATXN3 in response to starvation (Human) NCBITaxon:9606 gomodel:6482692800000330/6482692800000431 GO:0004843 cysteine-type deubiquitinase activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000499 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000508 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000516 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000531 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000544 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000557 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000570 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000577 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000592 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000601 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000609 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false GO:0140007 KICSTOR complex 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000642 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q8WTW4 NPRL2 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000653 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000672 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7Z3F1 GPR155 Hsap 6482692800000498 Activation of the canonical mTORC1 signaling by GPR155/LYCHOS in response to cholesterol influx (Human) NCBITaxon:9606 gomodel:6482692800000498/6482692800000691 GO:0015485 cholesterol binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000702 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000711 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000719 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000734 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000747 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000760 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000773 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000780 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000795 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000804 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000812 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false GO:0140007 KICSTOR complex 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000845 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q8WTW4 NPRL2 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000856 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000875 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q1RMZ1 SAMTOR Hsap 6482692800000701 Activation of the canonical mTORC1 signaling by BMT2/SAMTOR in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:6482692800000701/6482692800000904 GO:1904047 S-adenosyl-L-methionine binding GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q7L523 RRAGA Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001030 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001039 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001047 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001062 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001075 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001088 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001101 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001108 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001123 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001132 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001140 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q8WTW4 NPRL2 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001184 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001203 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q96S15 WDR24 Hsap 6482692800001029 Activation of the canonical mTORC1 signaling by GATOR2, which inactivates GATOR1 in response to abundant amino acids (Human) NCBITaxon:9606 gomodel:6482692800001029/6482692800001232 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001515 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001524 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001532 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001547 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001560 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001573 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001586 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001593 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001608 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001617 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001625 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q8WTW4 NPRL2 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001659 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q96S15 WDR24 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001689 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:Q13131 PRKAA1 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001709 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P54646 PRKAA2 Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001718 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P61981 YWHAG Hsap 6482692800001514 Inactivation of the canonical mTORC1 signaling via phosphorylation of WDR24 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001514/6482692800001727 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001740 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001751 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q8N122 RPTOR Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001762 GO:0140767 enzyme-substrate adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q13131 PRKAA1 Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001783 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P54646 PRKAA2 Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001792 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P63104 YWHAZ Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/6482692800001801 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:O15294 OGT Hsap 6482692800001739 Inhibition of the canonical mTORC1 signaling via phosphorylation of RPTOR by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001739/64d5781900000598 GO:0097363 protein O-acetylglucosaminyltransferase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q15382 RHEB Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001814 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001825 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001838 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001845 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001860 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001869 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001877 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P49815 TSC2 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001896 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q13131 PRKAA1 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001918 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P54646 PRKAA2 Hsap 6482692800001813 Inhibition of the canonical mTORC1 signaling following phosphorylation of TSC2 by AMPK in response to glucose starvation (Human) NCBITaxon:9606 gomodel:6482692800001813/6482692800001928 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q8WTX7 CASTOR1 Hsap 6482692800002004 Activation of the mTORC1 signaling by CASTOR1 in response to abundant arginine (Human) NCBITaxon:9606 gomodel:6482692800002004/6482692800002016 GO:0034618 arginine binding GO:1904263 positive regulation of TORC1 signaling GO:0005829 cytosol false UniProtKB:Q8WTX7 CASTOR1 Hsap 6482692800002004 Activation of the mTORC1 signaling by CASTOR1 in response to abundant arginine (Human) NCBITaxon:9606 gomodel:6482692800002004/6482692800002023 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling GO:0005829 cytosol false UniProtKB:Q96S15 WDR24 Hsap 6482692800002004 Activation of the mTORC1 signaling by CASTOR1 in response to abundant arginine (Human) NCBITaxon:9606 gomodel:6482692800002004/6482692800002052 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:P58004 SESN2 Hsap 6482692800002068 Activation of the mTORC1 signaling by SESN2 in response to abundant leucine (Human). NCBITaxon:9606 gomodel:6482692800002068/6482692800002070 GO:0140311 protein sequestering activity GO:1904262 negative regulation of TORC1 signaling GO:0005737 cytoplasm false UniProtKB:P58004 SESN2 Hsap 6482692800002068 Activation of the mTORC1 signaling by SESN2 in response to abundant leucine (Human). NCBITaxon:9606 gomodel:6482692800002068/6482692800002109 GO:0070728 L-leucine binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q96S15 WDR24 Hsap 6482692800002068 Activation of the mTORC1 signaling by SESN2 in response to abundant leucine (Human). NCBITaxon:9606 gomodel:6482692800002068/6482692800002127 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002659 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002713 GO:0004674 protein serine/threonine kinase activity GO:1900181 negative regulation of protein localization to nucleus GO:0005765 lysosomal membrane false UniProtKB:Q8NFG4 FLCN Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002838 GO:0005096 GTPase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002848 GO:0140767 enzyme-substrate adaptor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P63104 YWHAZ Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002879 GO:0140311 protein sequestering activity GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P19484 TFEB Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002890 GO:0003700 DNA-binding transcription factor activity GO:0007040 lysosome organization GO:0005634 nucleus false UniProtKB:P42345 MTOR Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002900 GO:0004674 protein serine/threonine kinase activity GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002913 GO:0140767 enzyme-substrate adaptor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P19532 TFE3 Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002929 GO:0003700 DNA-binding transcription factor activity GO:0007040 lysosome organization GO:0005634 nucleus false UniProtKB:Q9Y297 BTRC Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002936 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q13616 CUL1 Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002949 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6482692800002614 Non-canonical mTORC1 signaling leading to TFEB and TFE3 phosphorylation and inactivation (Human) NCBITaxon:9606 gomodel:6482692800002614/6482692800002959 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P42345 MTOR Hsap 648d0dc100000075 Positive regulation of autophagy via inhibition of MTOR by DEPTOR (Human) NCBITaxon:9606 gomodel:648d0dc100000075/648d0dc100000174 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 648d0dc100000075 Positive regulation of autophagy via inhibition of MTOR by DEPTOR (Human) NCBITaxon:9606 gomodel:648d0dc100000075/648d0dc100000234 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q8TB45 DEPTOR Hsap 648d0dc100000075 Positive regulation of autophagy via inhibition of MTOR by DEPTOR (Human) NCBITaxon:9606 gomodel:648d0dc100000075/648d0dc100000252 GO:0030291 protein serine/threonine kinase inhibitor activity GO:0010508 positive regulation of autophagy GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 648d0dc100000266 Inhibition of DEPTOR by phosphatidic acid (Human) NCBITaxon:9606 gomodel:648d0dc100000266/648d0dc100000267 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 648d0dc100000266 Inhibition of DEPTOR by phosphatidic acid (Human) NCBITaxon:9606 gomodel:648d0dc100000266/648d0dc100000281 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q8TB45 DEPTOR Hsap 648d0dc100000266 Inhibition of DEPTOR by phosphatidic acid (Human) NCBITaxon:9606 gomodel:648d0dc100000266/648d0dc100000296 GO:0030291 protein serine/threonine kinase inhibitor activity GO:0010508 positive regulation of autophagy GO:0005765 lysosomal membrane false UniProtKB:Q13393 PLD1 Hsap 648d0dc100000266 Inhibition of DEPTOR by phosphatidic acid (Human) NCBITaxon:9606 gomodel:648d0dc100000266/648d0dc100000312 GO:0004630 D-type glycerophospholipase activity GO:0031670 cellular response to nutrient false UniProtKB:P42345 MTOR Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000322 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000336 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q8TB45 DEPTOR Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000351 GO:0030291 protein serine/threonine kinase inhibitor activity GO:0010508 positive regulation of autophagy GO:0005765 lysosomal membrane false UniProtKB:Q13616 CUL1 Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000365 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q9Y297 BTRC Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000378 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000388 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P42345 MTOR Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000398 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000418 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P48729 CSNK1A1 Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000433 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000450 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P23443 RPS6KB1 Hsap 648d0dc100000321 Phosphorylation of DEPTOR in response to nutrients leads to its ubiquitination and degradation by the SCF(BTRC) complex (Human). NCBITaxon:9606 gomodel:648d0dc100000321/648d0dc100000461 GO:0004674 protein serine/threonine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 648d0dc100000710 Phosphorylation of DEPTOR by SYK impairs its ability to associate with MTOR (Human). NCBITaxon:9606 gomodel:648d0dc100000710/648d0dc100000711 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 648d0dc100000710 Phosphorylation of DEPTOR by SYK impairs its ability to associate with MTOR (Human). NCBITaxon:9606 gomodel:648d0dc100000710/648d0dc100000725 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q8TB45 DEPTOR Hsap 648d0dc100000710 Phosphorylation of DEPTOR by SYK impairs its ability to associate with MTOR (Human). NCBITaxon:9606 gomodel:648d0dc100000710/648d0dc100000740 GO:0030291 protein serine/threonine kinase inhibitor activity GO:0010508 positive regulation of autophagy GO:0005765 lysosomal membrane false UniProtKB:P43405 SYK Hsap 648d0dc100000710 Phosphorylation of DEPTOR by SYK impairs its ability to associate with MTOR (Human). NCBITaxon:9606 gomodel:648d0dc100000710/648d0dc100000859 GO:0004713 protein tyrosine kinase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 648d0dc100000867 Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). NCBITaxon:9606 gomodel:648d0dc100000867/648d0dc100000868 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75385 ULK1 Hsap 648d0dc100000867 Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). NCBITaxon:9606 gomodel:648d0dc100000867/648d0dc100000882 GO:0004674 protein serine/threonine kinase activity GO:0000045 autophagosome assembly GO:1903349 omegasome membrane false UniProtKB:Q8TB45 DEPTOR Hsap 648d0dc100000867 Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). NCBITaxon:9606 gomodel:648d0dc100000867/648d0dc100000897 GO:0030291 protein serine/threonine kinase inhibitor activity GO:0010508 positive regulation of autophagy GO:0005765 lysosomal membrane false UniProtKB:P27361 MAPK3 Hsap 648d0dc100000867 Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). NCBITaxon:9606 gomodel:648d0dc100000867/648d0dc100000919 GO:0004674 protein serine/threonine kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q93009 USP7 Hsap 648d0dc100000867 Phosphorylation of DEPTOR by MAPK3/ERK1 promotes DEPTOR deubiquitination by USP7 and enhanced protein stability (Human). NCBITaxon:9606 gomodel:648d0dc100000867/648d0dc100000926 GO:0004843 cysteine-type deubiquitinase activity GO:0050821 protein stabilization false UniProtKB:Q9HB90 RRAGC Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001318 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001359 GO:0004674 protein serine/threonine kinase activity GO:1900181 negative regulation of protein localization to nucleus GO:0005765 lysosomal membrane false UniProtKB:Q8NFG4 FLCN Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001402 GO:0005096 GTPase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001412 GO:0140767 enzyme-substrate adaptor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P63104 YWHAZ Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001429 GO:0140311 protein sequestering activity GO:1900181 negative regulation of protein localization to nucleus GO:0005829 cytosol false UniProtKB:P19484 TFEB Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001440 GO:0003700 DNA-binding transcription factor activity GO:0007040 lysosome organization GO:0005634 nucleus false UniProtKB:P42345 MTOR Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001448 GO:0004674 protein serine/threonine kinase activity GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001461 GO:0140767 enzyme-substrate adaptor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P19532 TFE3 Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001477 GO:0003700 DNA-binding transcription factor activity GO:0007040 lysosome organization GO:0005634 nucleus false UniProtKB:Q9Y297 BTRC Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001484 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q13616 CUL1 Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001495 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001505 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q8TF40 FNIP1 Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001513 GO:0008047 enzyme activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q13131 PRKAA1 Hsap 648d0dc100001272 Inhibition of the non-canonical mTORC1 signaling following phosphorylation of FNIP1 by AMPK in response to mitochondrial stress (Human). NCBITaxon:9606 gomodel:648d0dc100001272/648d0dc100001524 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q7Z434 MAVS Hsap 648d0dc100001547 Epstein-Barr BILF1 inhibition of NLRP3 inflammasome via MAVS UFMylation (Human-EBV) NCBITaxon:9606 gomodel:648d0dc100001547/648d0dc100001572 GO:0140693 molecular condensate scaffold activity GO:0140374 antiviral innate immune response GO:0005739 mitochondrion false UniProtKB:Q96P20 NLRP3 Hsap 648d0dc100001547 Epstein-Barr BILF1 inhibition of NLRP3 inflammasome via MAVS UFMylation (Human-EBV) NCBITaxon:9606 gomodel:648d0dc100001547/648d0dc100001580 GO:0140693 molecular condensate scaffold activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005739 mitochondrion false UniProtKB:P03208 648d0dc100001547 Epstein-Barr BILF1 inhibition of NLRP3 inflammasome via MAVS UFMylation (Human-EBV) NCBITaxon:9606 gomodel:648d0dc100001547/648d0dc100001591 GO:0030674 protein-macromolecule adaptor activity GO:1900226 negative regulation of NLRP3 inflammasome complex assembly GO:0005741 mitochondrial outer membrane false UniProtKB:O94874 UFL1 Hsap 648d0dc100001547 Epstein-Barr BILF1 inhibition of NLRP3 inflammasome via MAVS UFMylation (Human-EBV) NCBITaxon:9606 gomodel:648d0dc100001547/648d0dc100001598 GO:0061666 UFM1 ligase activity GO:0032880 regulation of protein localization GO:0005741 mitochondrial outer membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/6494e2e900000135 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q92985 IRF7 Hsap 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/6494e2e900000144 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q15633 TARBP2 Hsap 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/6494e2e900000152 GO:0140311 protein sequestering activity GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q68T42 Q68T42 NCBITaxon:42789 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/6494e2e900000162 GO:0140311 protein sequestering activity GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9UHD2 TBK1 Hsap 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/6494e2e900000172 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P40136 cya BACAN 6494e2e900000134 Regulation of IRF7 activation by enterovirus D68 protein VP3 (Human-enterovirus) NCBITaxon:9606 gomodel:6494e2e900000134/67e5e74400001477 GO:0140311 protein sequestering activity false UniProtKB:Q9Y6K9 IKBKG Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000188 GO:0035591 signaling adaptor activity GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process GO:0005829 cytosol false UniProtKB:P19838 NFKB1 Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000210 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q04206 RELA Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000217 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:O15111 CHUK Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000505 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O14920 IKBKB Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000516 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000526 GO:0140311 protein sequestering activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q6Q0C0 TRAF7 Hsap 6494e2e900000187 TRAF7 modulation of NF-kappa-B via IKBKG and NEMO K-29 ubquitination (Human) NCBITaxon:9606 gomodel:6494e2e900000187/6494e2e900000543 GO:0061630 ubiquitin protein ligase activity GO:0035519 protein K29-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q14154 DELE1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6494e2e900001857 GO:0043539 protein serine/threonine kinase activator activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:Q96E52 OMA1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6494e2e900001873 GO:0004222 metalloendopeptidase activity GO:0033554 cellular response to stress GO:0005758 mitochondrial intermembrane space false UniProtKB:Q9BQI3 EIF2AK1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6494e2e900001895 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6494e2e900001910 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q5T4S7 UBR4 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6606056e00001015 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9P0J7 KCMF1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6606056e00001031 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q5T4S7 UBR4 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6606056e00001048 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9P0J7 KCMF1 Hsap 6494e2e900001856 Inhibition of the HRI-mediated signaling by the SIFI complex via ubiquitination of DELE1 and EIF2AK1 by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6494e2e900001856/6606056e00001057 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q14154 DELE1 Hsap 6494e2e900001921 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to iron deficiency (Human) NCBITaxon:9606 gomodel:6494e2e900001921/6494e2e900001922 GO:0043539 protein serine/threonine kinase activator activity GO:0140468 HRI-mediated signaling GO:0005741 mitochondrial outer membrane false UniProtKB:Q9BQI3 EIF2AK1 Hsap 6494e2e900001921 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to iron deficiency (Human) NCBITaxon:9606 gomodel:6494e2e900001921/6494e2e900001956 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 6494e2e900001921 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to iron deficiency (Human) NCBITaxon:9606 gomodel:6494e2e900001921/6494e2e900001971 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9BXA5 SUCNR1 Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002526 GO:0004930 G protein-coupled receptor activity GO:0097009 energy homeostasis GO:0005886 plasma membrane false UniProtKB:Q13131 PRKAA1 Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002539 GO:0004679 AMP-activated protein kinase activity GO:0097009 energy homeostasis GO:0005737 cytoplasm false UniProtKB:P45983 MAPK8 Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002549 GO:0004705 JUN kinase activity GO:0097009 energy homeostasis GO:0005737 cytoplasm false UniProtKB:O00327 BMAL1 Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002559 GO:0003712 transcription coregulator activity GO:0032922 circadian regulation of gene expression GO:0005634 nucleus false UniProtKB:P49715 CEBPA Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002572 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0097009 energy homeostasis GO:0005634 nucleus false UniProtKB:P41159 LEP Hsap 6494e2e900002525 SUCNR1 in adipocytes controls energy homeostasis by modulating circadian clock and LEP expression. (Human) NCBITaxon:9606 gomodel:6494e2e900002525/6494e2e900002588 GO:0005179 hormone activity GO:0097009 energy homeostasis GO:0005576 extracellular region false UniProtKB:Q9BSA9 TMEM175 Hsap 64b9cb1500000603 Inhibition of proton channel activity of TMEM175 by LAMP1 and LAMP2 (Human) NCBITaxon:9606 gomodel:64b9cb1500000603/64b9cb1500000611 GO:0015252 proton channel activity GO:1902600 proton transmembrane transport GO:0005765 lysosomal membrane false UniProtKB:P11279 LAMP1 Hsap 64b9cb1500000603 Inhibition of proton channel activity of TMEM175 by LAMP1 and LAMP2 (Human) NCBITaxon:9606 gomodel:64b9cb1500000603/64b9cb1500000658 GO:0008200 ion channel inhibitor activity GO:0007042 lysosomal lumen acidification GO:0005765 lysosomal membrane false UniProtKB:P13473 LAMP2 Hsap 64b9cb1500000603 Inhibition of proton channel activity of TMEM175 by LAMP1 and LAMP2 (Human) NCBITaxon:9606 gomodel:64b9cb1500000603/64b9cb1500000665 GO:0008200 ion channel inhibitor activity GO:0007042 lysosomal lumen acidification GO:0005765 lysosomal membrane false UniProtKB:Q86WV6 STING1 Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000911 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000920 GO:0004674 protein serine/threonine kinase activity GO:0002218 activation of innate immune response GO:0005829 cytosol false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000929 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000952 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000979 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/64c3044100000997 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false GO:0000786 nucleosome 64c3044100000910 cGAS-STING signaling in the nucleus (Human) NCBITaxon:9606 gomodel:64c3044100000910/6918f23700000949 GO:0140678 molecular function inhibitor activity GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q86WV6 STING1 Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001130 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001139 GO:0004674 protein serine/threonine kinase activity GO:0002218 activation of innate immune response GO:0005829 cytosol false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001148 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001180 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001189 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100001129 cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:64c3044100001129/64c3044100001225 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100001348 Inhibition of cGAS-STING signaling by AURKB (Human) NCBITaxon:9606 gomodel:64c3044100001348/64c3044100001399 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100001348 Inhibition of cGAS-STING signaling by AURKB (Human) NCBITaxon:9606 gomodel:64c3044100001348/64c3044100001408 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100001348 Inhibition of cGAS-STING signaling by AURKB (Human) NCBITaxon:9606 gomodel:64c3044100001348/64c3044100001444 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q96GD4 AURKB Hsap 64c3044100001348 Inhibition of cGAS-STING signaling by AURKB (Human) NCBITaxon:9606 gomodel:64c3044100001348/64c3044100001476 GO:0004674 protein serine/threonine kinase activity GO:0044839 cell cycle G2/M phase transition false UniProtKB:Q8N884 CGAS Hsap 64c3044100001568 Positive regulation of cGAS-STING signaling by TRIM56 (Human) NCBITaxon:9606 gomodel:64c3044100001568/64c3044100001619 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100001568 Positive regulation of cGAS-STING signaling by TRIM56 (Human) NCBITaxon:9606 gomodel:64c3044100001568/64c3044100001628 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100001568 Positive regulation of cGAS-STING signaling by TRIM56 (Human) NCBITaxon:9606 gomodel:64c3044100001568/64c3044100001664 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q9BRZ2 TRIM56 Hsap 64c3044100001568 Positive regulation of cGAS-STING signaling by TRIM56 (Human) NCBITaxon:9606 gomodel:64c3044100001568/64c3044100001703 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination false UniProtKB:Q86WV6 STING1 Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001788 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001797 GO:0004674 protein serine/threonine kinase activity GO:0002218 activation of innate immune response GO:0005829 cytosol false UniProtKB:Q9UHD2 TBK1 Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001806 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001829 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001856 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100001874 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:O75531 BANF1 Hsap 64c3044100001787 Inhibition of cGAS-STING signaling in the nucleus by BANF1 (Human) NCBITaxon:9606 gomodel:64c3044100001787/64c3044100002007 GO:0003690 double-stranded DNA binding GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64c3044100002015 Inhibition of cGAS-STING signaling by PRKDC (Human) NCBITaxon:9606 gomodel:64c3044100002015/64c3044100002057 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100002015 Inhibition of cGAS-STING signaling by PRKDC (Human) NCBITaxon:9606 gomodel:64c3044100002015/64c3044100002084 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64c3044100002015 Inhibition of cGAS-STING signaling by PRKDC (Human) NCBITaxon:9606 gomodel:64c3044100002015/64c3044100002102 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway false UniProtKB:P78527 PRKDC Hsap 64c3044100002015 Inhibition of cGAS-STING signaling by PRKDC (Human) NCBITaxon:9606 gomodel:64c3044100002015/64c3044100002150 GO:0004674 protein serine/threonine kinase activity GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q8N884 CGAS Hsap 64d5781900000111 Activation of cGAS-STING signaling following acetylation by KAT5 (Human) NCBITaxon:9606 gomodel:64d5781900000111/64d5781900000153 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64d5781900000111 Activation of cGAS-STING signaling following acetylation by KAT5 (Human) NCBITaxon:9606 gomodel:64d5781900000111/64d5781900000180 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q8N884 CGAS Hsap 64d5781900000111 Activation of cGAS-STING signaling following acetylation by KAT5 (Human) NCBITaxon:9606 gomodel:64d5781900000111/64d5781900000198 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q92993-4 KAT5 Hsap 64d5781900000111 Activation of cGAS-STING signaling following acetylation by KAT5 (Human) NCBITaxon:9606 gomodel:64d5781900000111/64d5781900000224 GO:0061733 protein-lysine-acetyltransferase activity GO:0045089 positive regulation of innate immune response false UniProtKB:Q8N884 CGAS Hsap 64d5781900000443 Inhibition of cGAS-STING signaling in the cytosol by TREX1 (Human) NCBITaxon:9606 gomodel:64d5781900000443/64d5781900000485 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64d5781900000443 Inhibition of cGAS-STING signaling in the cytosol by TREX1 (Human) NCBITaxon:9606 gomodel:64d5781900000443/64d5781900000494 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 64d5781900000443 Inhibition of cGAS-STING signaling in the cytosol by TREX1 (Human) NCBITaxon:9606 gomodel:64d5781900000443/64d5781900000530 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9NSU2 TREX1 Hsap 64d5781900000443 Inhibition of cGAS-STING signaling in the cytosol by TREX1 (Human) NCBITaxon:9606 gomodel:64d5781900000443/64d5781900000547 GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity GO:0160049 negative regulation of cGAS/STING signaling pathway GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q7L523 RRAGA Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000647 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000660 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000673 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000688 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000701 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000714 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation GO:0005765 lysosomal membrane false UniProtKB:Q13541 EIF4EBP1 Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000727 GO:0030371 translation repressor activity GO:0045947 negative regulation of translational initiation false UniProtKB:P42345 MTOR Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000734 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P62753 RPS6 Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000749 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9UBS0 RPS6KB2 Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000758 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:P23443 RPS6KB1 Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000766 GO:0004674 protein serine/threonine kinase activity GO:0045948 positive regulation of translational initiation false UniProtKB:Q8N122 RPTOR Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000827 GO:0030674 protein-macromolecule adaptor activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O15294 OGT Hsap 64d5781900000615 Activation of canonical mTORC1 following glycosylation of RPTOR by OGT in response to glucose sufficiency (Human) NCBITaxon:9606 gomodel:64d5781900000615/64d5781900000845 GO:0097363 protein O-acetylglucosaminyltransferase activity GO:0071333 cellular response to glucose stimulus GO:0005829 cytosol false UniProtKB:O95786 RIGI Hsap 64d5781900001969 Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human) NCBITaxon:9606 gomodel:64d5781900001969/64d5781900001970 GO:0038187 pattern recognition receptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14258 TRIM25 Hsap 64d5781900001969 Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human) NCBITaxon:9606 gomodel:64d5781900001969/64d5781900001974 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 64d5781900001969 Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human) NCBITaxon:9606 gomodel:64d5781900001969/64d5781900001979 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0031966 mitochondrial membrane false UniProtKB:P62258 YWHAE Hsap 64d5781900001969 Role of 14-3-3epsilon (YWHAE) in RIGI signaling pathway (Human) NCBITaxon:9606 gomodel:64d5781900001969/64d5781900002020 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0031966 mitochondrial membrane false UniProtKB:P01308 INS Hsap 64d5781900002033 Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) NCBITaxon:9606 gomodel:64d5781900002033/64d5781900002034 GO:0005179 hormone activity GO:0010976 positive regulation of neuron projection development GO:0005576 extracellular region false UniProtKB:P41743 PRKCI Hsap 64d5781900002033 Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) NCBITaxon:9606 gomodel:64d5781900002033/64d5781900002041 GO:0004674 protein serine/threonine kinase activity GO:0010976 positive regulation of neuron projection development GO:0005829 cytosol false UniProtKB:O00213 APBB1 Hsap 64d5781900002033 Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) NCBITaxon:9606 gomodel:64d5781900002033/64d5781900002050 GO:0060090 molecular adaptor activity GO:0010976 positive regulation of neuron projection development GO:0005737 cytoplasm false UniProtKB:P62330 ARF6 Hsap 64d5781900002033 Insulin-mediated activation of the ARF6-RAC1 axis in neurite outgrowth (Human) NCBITaxon:9606 gomodel:64d5781900002033/64d5781900002062 GO:0003925 G protein activity GO:0010976 positive regulation of neuron projection development GO:0005829 cytosol false UniProtKB:Q9NPG8 ZDHHC4 Hsap 64d5781900002076 Role of ARF6 in CD36 localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:64d5781900002076/64d5781900002084 GO:0016409 palmitoyltransferase activity GO:0072659 protein localization to plasma membrane GO:0005794 Golgi apparatus false UniProtKB:P62330 ARF6 Hsap 64d5781900002076 Role of ARF6 in CD36 localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:64d5781900002076/64d5781900002093 GO:0030674 protein-macromolecule adaptor activity GO:0072659 protein localization to plasma membrane GO:0005794 Golgi apparatus false UniProtKB:P16671 CD36 Hsap 64d5781900002076 Role of ARF6 in CD36 localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:64d5781900002076/64d5781900002103 GO:0070892 lipoteichoic acid immune receptor activity GO:0071726 cellular response to diacyl bacterial lipopeptide GO:0005886 plasma membrane false UniProtKB:Q14142 TRIM14 Hsap 64d5781900002111 KDM4D stabilization by TRIM14-USP14 (Human) NCBITaxon:9606 gomodel:64d5781900002111/64d5781900002112 GO:0060090 molecular adaptor activity GO:0006954 inflammatory response GO:0005737 cytoplasm false UniProtKB:P54578 USP14 Hsap 64d5781900002111 KDM4D stabilization by TRIM14-USP14 (Human) NCBITaxon:9606 gomodel:64d5781900002111/64d5781900002119 GO:0004843 cysteine-type deubiquitinase activity GO:0071108 protein K48-linked deubiquitination GO:0005737 cytoplasm false UniProtKB:Q6B0I6 KDM4D Hsap 64d5781900002111 KDM4D stabilization by TRIM14-USP14 (Human) NCBITaxon:9606 gomodel:64d5781900002111/64d5781900002127 GO:0140684 histone H3K9me2/H3K9me3 demethylase activity GO:0006954 inflammatory response GO:0005634 nucleus false UniProtKB:Q96PU8 QKI Hsap 64e7eefa00000034 QKI shuttle m7G-modified mRNAs into cytoplasmic stress granules (Human). NCBITaxon:9606 gomodel:64e7eefa00000034/64e7eefa00000035 GO:0160089 internal N(7)-methylguanine-containing RNA reader activity GO:0051028 mRNA transport GO:0005634 nucleus false UniProtKB:Q9UBP6 METTL1 Hsap 64e7eefa00000034 QKI shuttle m7G-modified mRNAs into cytoplasmic stress granules (Human). NCBITaxon:9606 gomodel:64e7eefa00000034/64e7eefa00000042 GO:0160090 internal mRNA (guanine-N7-)-methyltransferase activity GO:0033554 cellular response to stress GO:0005634 nucleus false UniProtKB:Q13283 G3BP1 Hsap 64e7eefa00000034 QKI shuttle m7G-modified mRNAs into cytoplasmic stress granules (Human). NCBITaxon:9606 gomodel:64e7eefa00000034/64e7eefa00000051 GO:0140693 molecular condensate scaffold activity GO:0034063 stress granule assembly GO:0010494 cytoplasmic stress granule false UniProtKB:Q16222 UAP1 Hsap 64e7eefa00000065 UAP1 catalyzes pyrophosphorylation of IRF3, promoting IRF3 activation (Human) NCBITaxon:9606 gomodel:64e7eefa00000065/64e7eefa00000066 GO:0141090 protein serine pyrophosphorylase activity GO:0140374 antiviral innate immune response GO:0005829 cytosol false UniProtKB:Q9UHD2 TBK1 Hsap 64e7eefa00000065 UAP1 catalyzes pyrophosphorylation of IRF3, promoting IRF3 activation (Human) NCBITaxon:9606 gomodel:64e7eefa00000065/64e7eefa00000077 GO:0004674 protein serine/threonine kinase activity GO:0140374 antiviral innate immune response GO:0005829 cytosol false UniProtKB:Q14653 IRF3 Hsap 64e7eefa00000065 UAP1 catalyzes pyrophosphorylation of IRF3, promoting IRF3 activation (Human) NCBITaxon:9606 gomodel:64e7eefa00000065/64e7eefa00000089 GO:0003700 DNA-binding transcription factor activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q9BSD3 RHNO1 Hsap 64e7eefa00000404 TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). NCBITaxon:9606 gomodel:64e7eefa00000404/64e7eefa00000405 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:P53350 PLK1 Hsap 64e7eefa00000404 TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). NCBITaxon:9606 gomodel:64e7eefa00000404/64e7eefa00000416 GO:0004674 protein serine/threonine kinase activity GO:0097681 double-strand break repair via alternative nonhomologous end joining false UniProtKB:O75417 POLQ Hsap 64e7eefa00000404 TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). NCBITaxon:9606 gomodel:64e7eefa00000404/64e7eefa00000423 GO:0003887 DNA-directed DNA polymerase activity GO:0097681 double-strand break repair via alternative nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:P53350 PLK1 Hsap 64e7eefa00000404 TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). NCBITaxon:9606 gomodel:64e7eefa00000404/64e7eefa00002039 GO:0004674 protein serine/threonine kinase activity GO:0097681 double-strand break repair via alternative nonhomologous end joining false UniProtKB:Q92547 TOPBP1 Hsap 64e7eefa00000404 TOPBP1 and RHNO1 mediate POLQ recruitment to DNA damage sites during mitosis to promote microhomology-mediated end-joining (MMEJ) (Human). NCBITaxon:9606 gomodel:64e7eefa00000404/64e7eefa00002048 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q9P0U3 SENP1 Hsap 64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) NCBITaxon:9606 gomodel:64e7eefa00001258/64e7eefa00001259 GO:0070139 SUMO-specific endopeptidase activity GO:0043488 regulation of mRNA stability false UniProtKB:Q8N2W9 PIAS4 Hsap 64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) NCBITaxon:9606 gomodel:64e7eefa00001258/64e7eefa00001266 GO:0061665 SUMO ligase activity GO:0043488 regulation of mRNA stability false UniProtKB:Q6P6C2 ALKBH5 Hsap 64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) NCBITaxon:9606 gomodel:64e7eefa00001258/64e7eefa00001273 GO:1990931 mRNA N6-methyladenosine dioxygenase activity GO:0061157 mRNA destabilization GO:0016607 nuclear speck false UniProtKB:P45983 MAPK8 Hsap 64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) NCBITaxon:9606 gomodel:64e7eefa00001258/64e7eefa00001280 GO:0004674 protein serine/threonine kinase activity GO:0034614 cellular response to reactive oxygen species false UniProtKB:P45984 MAPK9 Hsap 64e7eefa00001258 Inhibition of ALKBH5 RNA demethylase activity by sumoylation in response to reactive oxygen species (Human) NCBITaxon:9606 gomodel:64e7eefa00001258/64e7eefa00001287 GO:0004674 protein serine/threonine kinase activity GO:0034614 cellular response to reactive oxygen species false UniProtKB:Q9P0U3 SENP1 Hsap 64e7eefa00001299 RBM33 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase (Human) NCBITaxon:9606 gomodel:64e7eefa00001299/64e7eefa00001300 GO:0070139 SUMO-specific endopeptidase activity GO:0043488 regulation of mRNA stability false UniProtKB:Q6P6C2 ALKBH5 Hsap 64e7eefa00001299 RBM33 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase (Human) NCBITaxon:9606 gomodel:64e7eefa00001299/64e7eefa00001314 GO:1990931 mRNA N6-methyladenosine dioxygenase activity GO:0061157 mRNA destabilization GO:0016607 nuclear speck false UniProtKB:Q96EV2 RBM33 Hsap 64e7eefa00001299 RBM33 binds N6-methyladenosine (m6A)-containing mRNAs and promotes their demethylation by ALKBH5 RNA demethylase (Human) NCBITaxon:9606 gomodel:64e7eefa00001299/64e7eefa00001347 GO:1990247 N6-methyladenosine-containing RNA reader activity GO:0043488 regulation of mRNA stability false UniProtKB:Q6P6C2 ALKBH5 Hsap 64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). NCBITaxon:9606 gomodel:64e7eefa00001978/64e7eefa00001979 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0042382 paraspeckles false UniProtKB:Q6P6C2 ALKBH5 Hsap 64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). NCBITaxon:9606 gomodel:64e7eefa00001978/64e7eefa00001986 GO:1990931 mRNA N6-methyladenosine dioxygenase activity GO:0140694 membraneless organelle assembly GO:0042382 paraspeckles false UniProtKB:Q9H7Z6 KAT8 Hsap 64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). NCBITaxon:9606 gomodel:64e7eefa00001978/64e7eefa00001994 GO:0061733 protein-lysine-acetyltransferase activity GO:0050684 regulation of mRNA processing false UniProtKB:Q8WXF1 PSPC1 Hsap 64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). NCBITaxon:9606 gomodel:64e7eefa00001978/64e7eefa00002001 GO:0003723 RNA binding GO:0140694 membraneless organelle assembly GO:0042382 paraspeckles false UniProtKB:Q8WUI4 HDAC7 Hsap 64e7eefa00001978 ALKBH5 is involved in paraspeckle assembly and is regulated by acetylation and deacetylation by KAT8 and HDAC7, respectively (Human). NCBITaxon:9606 gomodel:64e7eefa00001978/64e7eefa00002010 GO:0033558 protein lysine deacetylase activity GO:0050684 regulation of mRNA processing false UniProtKB:Q13535 ATR Hsap 65039e8700000010 Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) NCBITaxon:9606 gomodel:65039e8700000010/65039e8700000011 GO:0035979 histone H2AXS139 kinase activity GO:0006974 DNA damage response false UniProtKB:Q14676 MDC1 Hsap 65039e8700000010 Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) NCBITaxon:9606 gomodel:65039e8700000010/65039e8700000021 GO:0140566 histone reader activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q92547 TOPBP1 Hsap 65039e8700000010 Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) NCBITaxon:9606 gomodel:65039e8700000010/65039e8700000033 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:P68400 CSNK2A1 Hsap 65039e8700000010 Recruitment of TOPBP1 to DNA damage sites by MDC1 during mitosis (Human) NCBITaxon:9606 gomodel:65039e8700000010/65039e8700000045 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:P68400 CSNK2A1 Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000056 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:Q92547 TOPBP1 Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000063 GO:0140463 chromatin-protein adaptor activity GO:0097680 double-strand break repair via classical nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q92547 TOPBP1 Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000080 GO:0140031 phosphorylation-dependent protein binding GO:0097680 double-strand break repair via classical nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q8IYW5 RNF168 Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000091 GO:0140858 histone H2AK15 ubiquitin ligase activity GO:0097680 double-strand break repair via classical nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q12888 TP53BP1 Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000098 GO:0140566 histone reader activity GO:0097680 double-strand break repair via classical nonhomologous end joining GO:0035861 site of double-strand break false UniProtKB:Q13535 ATR Hsap 65039e8700000055 Phosphorylation-mediated interactions with TOPBP1 couples TP53BP1 and 9-1-1 in DNA damage checkpoint (Human). NCBITaxon:9606 gomodel:65039e8700000055/65039e8700000109 GO:0004674 protein serine/threonine kinase activity GO:0006302 double-strand break repair false UniProtKB:Q13535 ATR Hsap 65039e8700000123 ATR autophosphorylation leads to interaction with TOPBP1 and ATR activation (Human). NCBITaxon:9606 gomodel:65039e8700000123/65039e8700000124 GO:0004674 protein serine/threonine kinase activity GO:0000077 DNA damage checkpoint signaling GO:0090734 site of DNA damage false UniProtKB:Q92547 TOPBP1 Hsap 65039e8700000123 ATR autophosphorylation leads to interaction with TOPBP1 and ATR activation (Human). NCBITaxon:9606 gomodel:65039e8700000123/65039e8700000136 GO:0140463 chromatin-protein adaptor activity GO:0000077 DNA damage checkpoint signaling GO:0090734 site of DNA damage false UniProtKB:Q13535 ATR Hsap 65039e8700000123 ATR autophosphorylation leads to interaction with TOPBP1 and ATR activation (Human). NCBITaxon:9606 gomodel:65039e8700000123/65039e8700000145 GO:0004674 protein serine/threonine kinase activity GO:0000077 DNA damage checkpoint signaling GO:0090734 site of DNA damage false UniProtKB:P09874 PARP1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000197 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity GO:0006302 double-strand break repair false UniProtKB:P68400 CSNK2A1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000206 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:O43719 HTATSF1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000215 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q92547 TOPBP1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000228 GO:0140463 chromatin-protein adaptor activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false GO:0005662 DNA replication factor A complex 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000242 GO:0003684 damaged DNA binding GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q06609 RAD51 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000250 GO:0000150 DNA strand exchange activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P53350 PLK1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000273 GO:0004674 protein serine/threonine kinase activity GO:0006302 double-strand break repair false UniProtKB:P68400 CSNK2A1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000280 GO:0004674 protein serine/threonine kinase activity GO:0006302 double-strand break repair false UniProtKB:P27694 RPA1 Hsap 65039e8700000196 HTATSF1 and TOPBP1 promote RPA-RAD51 exchange in double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65039e8700000196/65039e8700000397 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:O15455 TLR3 Hsap 65039e8700000921 RNF170-mediated ubiquitination of TLR3 leading to TLR3 degradation (Human) NCBITaxon:9606 gomodel:65039e8700000921/65039e8700000922 GO:0038187 pattern recognition receptor activity GO:0002224 toll-like receptor signaling pathway GO:0005769 early endosome false UniProtKB:Q8IUC6 TICAM1 Hsap 65039e8700000921 RNF170-mediated ubiquitination of TLR3 leading to TLR3 degradation (Human) NCBITaxon:9606 gomodel:65039e8700000921/65039e8700000942 GO:0060090 molecular adaptor activity GO:0002224 toll-like receptor signaling pathway GO:0005769 early endosome false UniProtKB:Q96K19 RNF170 Hsap 65039e8700000921 RNF170-mediated ubiquitination of TLR3 leading to TLR3 degradation (Human) NCBITaxon:9606 gomodel:65039e8700000921/65039e8700000951 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005789 endoplasmic reticulum membrane false UniProtKB:F5HF68 vIRF-1 NCBITaxon:868565 65039e8700000967 Kaposi herpesvirus vIRF-1 inhibition of SIRT6 by preventing its deubiquitination (Human-Herpesvirus) NCBITaxon:9606 gomodel:65039e8700000967/65039e8700000968 GO:0140311 protein sequestering activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0042025 host cell nucleus false UniProtKB:Q14694 USP10 Hsap 65039e8700000967 Kaposi herpesvirus vIRF-1 inhibition of SIRT6 by preventing its deubiquitination (Human-Herpesvirus) NCBITaxon:9606 gomodel:65039e8700000967/65039e8700000979 GO:0004843 cysteine-type deubiquitinase activity GO:0016579 protein deubiquitination GO:0005634 nucleus false UniProtKB:Q8N6T7 SIRT6 Hsap 65039e8700000967 Kaposi herpesvirus vIRF-1 inhibition of SIRT6 by preventing its deubiquitination (Human-Herpesvirus) NCBITaxon:9606 gomodel:65039e8700000967/65039e8700000989 GO:0140612 DNA damage sensor activity GO:0006338 chromatin remodeling GO:0000785 chromatin false UniProtKB:Q86WT6 TRIM69 Hsap 65039e8700001110 TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) NCBITaxon:9606 gomodel:65039e8700001110/65039e8700001111 GO:0061630 ubiquitin protein ligase activity GO:0071539 protein localization to centrosome GO:0005813 centrosome false UniProtKB:P53350 PLK1 Hsap 65039e8700001110 TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) NCBITaxon:9606 gomodel:65039e8700001110/65039e8700001118 GO:0106310 protein serine kinase activity GO:0007098 centrosome cycle GO:0005813 centrosome false UniProtKB:Q13188 STK3 Hsap 65039e8700001110 TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) NCBITaxon:9606 gomodel:65039e8700001110/65039e8700001130 GO:0004674 protein serine/threonine kinase activity GO:0071539 protein localization to centrosome GO:0005813 centrosome false UniProtKB:P51955 NEK2 Hsap 65039e8700001110 TRIM69 activation of STK3 by ubiquitination leading to centrosome separation (Human) NCBITaxon:9606 gomodel:65039e8700001110/65039e8700001138 GO:0004672 protein kinase activity GO:0051299 centrosome separation GO:0005813 centrosome false UniProtKB:Q96T88 UHRF1 Hsap 65039e8700001188 KIF11 ubiquitination leading to mitotic spindle assembly (Human) NCBITaxon:9606 gomodel:65039e8700001188/65039e8700001189 GO:0061630 ubiquitin protein ligase activity GO:0090307 mitotic spindle assembly GO:0005819 spindle false UniProtKB:Q9ULW0 TPX2 Hsap 65039e8700001188 KIF11 ubiquitination leading to mitotic spindle assembly (Human) NCBITaxon:9606 gomodel:65039e8700001188/65039e8700001198 GO:0060090 molecular adaptor activity GO:0090307 mitotic spindle assembly GO:0005819 spindle false UniProtKB:P52732 KIF11 Hsap 65039e8700001188 KIF11 ubiquitination leading to mitotic spindle assembly (Human) NCBITaxon:9606 gomodel:65039e8700001188/65039e8700001208 GO:0003777 microtubule motor activity GO:0090307 mitotic spindle assembly GO:0005819 spindle false UniProtKB:Q9BXC1 GPR174 Hsap 65288b2200000062 GPR174 signaling pathway (Human) NCBITaxon:9606 gomodel:65288b2200000062/65288b2200000063 GO:0004930 G protein-coupled receptor activity GO:0032703 negative regulation of interleukin-2 production GO:0005886 plasma membrane false UniProtKB:P17612 PRKACA Hsap 65288b2200000062 GPR174 signaling pathway (Human) NCBITaxon:9606 gomodel:65288b2200000062/65288b2200000090 GO:0004691 cAMP-dependent protein kinase activity GO:0032703 negative regulation of interleukin-2 production GO:0005737 cytoplasm false UniProtKB:P60568 IL2 Hsap 65288b2200000062 GPR174 signaling pathway (Human) NCBITaxon:9606 gomodel:65288b2200000062/65288b2200000103 GO:0005125 cytokine activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P63092 GNAS Hsap 65288b2200000062 GPR174 signaling pathway (Human) NCBITaxon:9606 gomodel:65288b2200000062/6796b94c00004092 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 65288b2200000062 GPR174 signaling pathway (Human) NCBITaxon:9606 gomodel:65288b2200000062/6796b94c00004100 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9H1Y0 ATG5 Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000289 GO:0019776 Atg8-family ligase activity GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q9GZQ8 MAP1LC3B Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000306 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9Y4P1 ATG4B Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000355 GO:0004197 cysteine-type endopeptidase activity GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q96DT6 ATG4C Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000358 GO:0004197 cysteine-type endopeptidase activity GO:0000045 autophagosome assembly false UniProtKB:Q86TL0-2 ATG4D Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000361 GO:0070004 cysteine-type exopeptidase activity GO:0000045 autophagosome assembly false UniProtKB:Q86WV6 STING1 Hsap 65288b2200000194 STING1 acts as a proton channel and promotes autophagosome assembly (Human) NCBITaxon:9606 gomodel:65288b2200000194/65288b2200000488 GO:0015252 proton channel activity GO:0000045 autophagosome assembly GO:0000139 Golgi membrane false UniProtKB:Q8N884 CGAS Hsap 65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). NCBITaxon:9606 gomodel:65288b2200000496/65288b2200000529 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). NCBITaxon:9606 gomodel:65288b2200000496/65288b2200000538 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). NCBITaxon:9606 gomodel:65288b2200000496/65288b2200000556 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9Y397 ZDHHC9 Hsap 65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). NCBITaxon:9606 gomodel:65288b2200000496/65288b2200000572 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0141111 positive regulation of cGAS/STING signaling pathway false UniProtKB:Q5VWZ2 LYPLAL1 Hsap 65288b2200000496 Regulation of CGAS activity via palmitoylation and depalmitoylation by ZDHHC9 and LYPLAL1, respectively (Human). NCBITaxon:9606 gomodel:65288b2200000496/65288b2200000579 GO:0008474 palmitoyl-(protein) hydrolase activity GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q86WV6 STING1 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000644 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000662 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q86WV6 STING1 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000719 GO:0035591 signaling adaptor activity GO:0070972 protein localization to endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9H5V9 STEEP1 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000730 GO:0030674 protein-macromolecule adaptor activity GO:0090158 endoplasmic reticulum membrane organization GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15750 TAB1 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000744 GO:0043539 protein serine/threonine kinase activator activity GO:0141111 positive regulation of cGAS/STING signaling pathway GO:0005789 endoplasmic reticulum membrane false UniProtKB:O43318-4 MAP3K7 Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/65288b2200000753 GO:0004674 protein serine/threonine kinase activity GO:0141111 positive regulation of cGAS/STING signaling pathway GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8N884 CGAS Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/69729a3800007745 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9Y2I7 PIKFYVE Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/698e557b00000070 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity GO:0141111 positive regulation of cGAS/STING signaling pathway false UniProtKB:P53992 SEC24C Hsap 65288b2200000643 STING1 trafficking from the endoplasmic reticulum to the ERGIC following phosphorylation by MAP3K7/TAK1, interaction with STEEP1 and association with SEC24C component of COPII vesicles (Human). NCBITaxon:9606 gomodel:65288b2200000643/69d8496c00002068 GO:0140312 cargo adaptor activity GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9BYV6 TRIM55 Hsap 65288b2200001166 TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) NCBITaxon:9606 gomodel:65288b2200001166/65288b2200001167 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9BYV6 TRIM55 Hsap 65288b2200001166 TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) NCBITaxon:9606 gomodel:65288b2200001166/65288b2200001178 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19474 TRIM21 Hsap 65288b2200001166 TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) NCBITaxon:9606 gomodel:65288b2200001166/65288b2200001189 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P55072 VCP Hsap 65288b2200001166 TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) NCBITaxon:9606 gomodel:65288b2200001166/65288b2200001199 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q00653 NFKB2 Hsap 65288b2200001166 TRIM55 and TRIM21-mediated inhibition of NFKB2 (Human) NCBITaxon:9606 gomodel:65288b2200001166/65288b2200001210 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007249 canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:Q93008 USP9X Hsap 65288b2200001218 USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) NCBITaxon:9606 gomodel:65288b2200001218/65288b2200001219 GO:0101005 deubiquitinase activity GO:0061824 cytosolic ciliogenesis GO:0005813 centrosome false UniProtKB:Q15051 IQCB1 Hsap 65288b2200001218 USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) NCBITaxon:9606 gomodel:65288b2200001218/65288b2200001230 GO:0030674 protein-macromolecule adaptor activity GO:0061824 cytosolic ciliogenesis GO:0005813 centrosome false UniProtKB:Q13049 TRIM32 Hsap 65288b2200001218 USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) NCBITaxon:9606 gomodel:65288b2200001218/65288b2200001240 GO:0061630 ubiquitin protein ligase activity GO:1902018 negative regulation of cilium assembly GO:0005813 centrosome false UniProtKB:Q15051 IQCB1 Hsap 65288b2200001218 USP9X-TRIM32 modulation of IQCB1 during G1-S (Human) NCBITaxon:9606 gomodel:65288b2200001218/65288b2200001254 GO:0062063 BBSome binding GO:0061824 cytosolic ciliogenesis GO:0005813 centrosome false UniProtKB:Q13049 TRIM32 Hsap 65288b2200001267 USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) NCBITaxon:9606 gomodel:65288b2200001267/65288b2200001268 GO:0061630 ubiquitin protein ligase activity GO:1902018 negative regulation of cilium assembly GO:0005813 centrosome false UniProtKB:Q15051 IQCB1 Hsap 65288b2200001267 USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) NCBITaxon:9606 gomodel:65288b2200001267/65288b2200001277 GO:0030674 protein-macromolecule adaptor activity GO:0060271 cilium assembly GO:0005813 centrosome false UniProtKB:Q9H992 MARCHF7 Hsap 65288b2200001267 USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) NCBITaxon:9606 gomodel:65288b2200001267/65288b2200001289 GO:0061630 ubiquitin protein ligase activity GO:1902018 negative regulation of cilium assembly GO:0005813 centrosome false UniProtKB:Q93008 USP9X Hsap 65288b2200001267 USP9X-TRIM32 modulation of IQCB1 during G2-M (Human) NCBITaxon:9606 gomodel:65288b2200001267/65288b2200001299 GO:0140313 molecular sequestering activity GO:0060271 cilium assembly GO:0005737 cytoplasm false UniProtKB:P05231 IL6 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000017 GO:0005125 cytokine activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P08887-2 IL6R Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000023 GO:0004896 cytokine receptor activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P40189-2 IL6ST Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000028 GO:0030296 protein tyrosine kinase activator activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000033 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000036 GO:0003700 DNA-binding transcription factor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:O14543 SOCS3 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000039 GO:0019210 kinase inhibitor activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005829 cytosol false UniProtKB:Q09472 EP300 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000099 GO:0061733 protein-lysine-acetyltransferase activity GO:2000330 positive regulation of T-helper 17 cell lineage commitment false UniProtKB:P25440 BRD2 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000107 GO:0140033 acetylation-dependent protein binding GO:0071168 protein localization to chromatin false UniProtKB:P58215 LOXL3 Hsap 653b0ce600000016 Regulation of T-helper 17 cell lineage commitment by acetylation and deacetylation of STAT3 (Human) NCBITaxon:9606 gomodel:653b0ce600000016/653b0ce600000116 GO:0004720 protein-lysine 6-oxidase activity GO:2000329 negative regulation of T-helper 17 cell lineage commitment false UniProtKB:Q09472 EP300 Hsap 653b0ce600000202 BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). NCBITaxon:9606 gomodel:653b0ce600000202/653b0ce600000203 GO:0043993 histone H3K18 acetyltransferase activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q15059 BRD3 Hsap 653b0ce600000202 BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). NCBITaxon:9606 gomodel:653b0ce600000202/653b0ce600000210 GO:0140566 histone reader activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q15059 BRD3 Hsap 653b0ce600000202 BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). NCBITaxon:9606 gomodel:653b0ce600000202/653b0ce600000217 GO:0140693 molecular condensate scaffold activity GO:0035987 endodermal cell differentiation GO:0000785 chromatin false RNAcentral:URS0000A77281_9606 URS0000A77281_9606 Hsap 653b0ce600000202 BRD3 and lncRNA DIGIT form phase-separated condensates to induce endoderm cell differentiation (Human). NCBITaxon:9606 gomodel:653b0ce600000202/653b0ce600000224 GO:0005515 protein binding GO:0035987 endodermal cell differentiation false UniProtKB:Q86VP1 TAX1BP1 Hsap 653b0ce600000382 TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human) NCBITaxon:9606 gomodel:653b0ce600000382/653b0ce600000383 GO:0030674 protein-macromolecule adaptor activity GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway GO:0005739 mitochondrion false UniProtKB:Q96J02 ITCH Hsap 653b0ce600000382 TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human) NCBITaxon:9606 gomodel:653b0ce600000382/653b0ce600000394 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005739 mitochondrion false UniProtKB:Q7Z434 MAVS Hsap 653b0ce600000382 TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human) NCBITaxon:9606 gomodel:653b0ce600000382/653b0ce600000404 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005739 mitochondrion false UniProtKB:Q9Y228 TRAF3IP3 Hsap 653b0ce600000382 TAX1BP1-mediated degradation of MAVS by E3 ligase ITCH (Human) NCBITaxon:9606 gomodel:653b0ce600000382/653b0ce600000414 GO:0060090 molecular adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005739 mitochondrion false UniProtKB:O00206 TLR4 Hsap 653b0ce600000432 TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) NCBITaxon:9606 gomodel:653b0ce600000432/653b0ce600000433 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q86XR7 TICAM2 Hsap 653b0ce600000432 TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) NCBITaxon:9606 gomodel:653b0ce600000432/653b0ce600000436 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q8IUC6 TICAM1 Hsap 653b0ce600000432 TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) NCBITaxon:9606 gomodel:653b0ce600000432/653b0ce600000450 GO:0060090 molecular adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0010008 endosome membrane false UniProtKB:Q13049 TRIM32 Hsap 653b0ce600000432 TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) NCBITaxon:9606 gomodel:653b0ce600000432/653b0ce600000492 GO:0030674 protein-macromolecule adaptor activity GO:0034144 negative regulation of toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q86VP1 TAX1BP1 Hsap 653b0ce600000432 TRIM32-TAX1BP1-dependent selective autophagic degradation of TICAM1 (Human) NCBITaxon:9606 gomodel:653b0ce600000432/653b0ce600000503 GO:0030674 protein-macromolecule adaptor activity GO:1905161 protein localization to phagocytic vesicle GO:0005737 cytoplasm false UniProtKB:P02545 LMNA Hsap 653b0ce600000623 Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000623/653b0ce600000624 GO:0160123 structural constituent of nuclear lamina GO:0006998 nuclear envelope organization GO:0005652 nuclear lamina false UniProtKB:P06493 CDK1 Hsap 653b0ce600000623 Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000623/653b0ce600000631 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0007077 mitotic nuclear membrane disassembly false UniProtKB:P30304 CDC25A Hsap 653b0ce600000623 Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000623/653b0ce600000641 GO:0004725 protein tyrosine phosphatase activity GO:0010971 positive regulation of G2/M transition of mitotic cell cycle false UniProtKB:P30291 WEE1 Hsap 653b0ce600000623 Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000623/653b0ce600000651 GO:0004713 protein tyrosine kinase activity GO:0010972 negative regulation of G2/M transition of mitotic cell cycle false UniProtKB:O14757 CHEK1 Hsap 653b0ce600000623 Negative regulation of the G2/M transition of the cell cycle via inhibition of CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000623/653b0ce600000663 GO:0004674 protein serine/threonine kinase activity GO:0044818 mitotic G2/M transition checkpoint false UniProtKB:P02545 LMNA Hsap 653b0ce600000673 G2/M transition of the cell cycle via phosphorylation of LMNA by CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000673/653b0ce600000674 GO:0160123 structural constituent of nuclear lamina GO:0006998 nuclear envelope organization GO:0005652 nuclear lamina false UniProtKB:P06493 CDK1 Hsap 653b0ce600000673 G2/M transition of the cell cycle via phosphorylation of LMNA by CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000673/653b0ce600000681 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0007077 mitotic nuclear membrane disassembly false UniProtKB:P30304 CDC25A Hsap 653b0ce600000673 G2/M transition of the cell cycle via phosphorylation of LMNA by CDK1 (Human). NCBITaxon:9606 gomodel:653b0ce600000673/653b0ce600000691 GO:0004725 protein tyrosine phosphatase activity GO:0000086 G2/M transition of mitotic cell cycle false UniProtKB:Q9NY74 ETAA1 Hsap 653b0ce600000721 A checkpoint mediated by ATR that restricts activation of CDK1 during S-phase (Human). NCBITaxon:9606 gomodel:653b0ce600000721/653b0ce600000734 GO:0043539 protein serine/threonine kinase activator activity GO:0044818 mitotic G2/M transition checkpoint false UniProtKB:Q13535 ATR Hsap 653b0ce600000721 A checkpoint mediated by ATR that restricts activation of CDK1 during S-phase (Human). NCBITaxon:9606 gomodel:653b0ce600000721/653b0ce600000743 GO:0004674 protein serine/threonine kinase activity GO:0044818 mitotic G2/M transition checkpoint false UniProtKB:P06493 CDK1 Hsap 653b0ce600000721 A checkpoint mediated by ATR that restricts activation of CDK1 during S-phase (Human). NCBITaxon:9606 gomodel:653b0ce600000721/653b0ce600000765 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0000086 G2/M transition of mitotic cell cycle false UniProtKB:Q08050 FOXM1 Hsap 653b0ce600000721 A checkpoint mediated by ATR that restricts activation of CDK1 during S-phase (Human). NCBITaxon:9606 gomodel:653b0ce600000721/653b0ce600000773 GO:0003700 DNA-binding transcription factor activity GO:0000086 G2/M transition of mitotic cell cycle false UniProtKB:P49354 FNTA Hsap 653b0ce600000800 LMNA (Lamin-A/C) maturation (Human). NCBITaxon:9606 gomodel:653b0ce600000800/653b0ce600000801 GO:0004660 protein farnesyltransferase activity GO:0051604 protein maturation false UniProtKB:O75844 ZMPSTE24 Hsap 653b0ce600000800 LMNA (Lamin-A/C) maturation (Human). NCBITaxon:9606 gomodel:653b0ce600000800/653b0ce600000808 GO:0004175 endopeptidase activity GO:0051604 protein maturation false UniProtKB:O60725 ICMT Hsap 653b0ce600000800 LMNA (Lamin-A/C) maturation (Human). NCBITaxon:9606 gomodel:653b0ce600000800/653b0ce600000815 GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0051604 protein maturation false UniProtKB:O75844 ZMPSTE24 Hsap 653b0ce600000800 LMNA (Lamin-A/C) maturation (Human). NCBITaxon:9606 gomodel:653b0ce600000800/653b0ce600000822 GO:0004175 endopeptidase activity GO:0051604 protein maturation false UniProtKB:P02545 LMNA Hsap 653b0ce600000800 LMNA (Lamin-A/C) maturation (Human). NCBITaxon:9606 gomodel:653b0ce600000800/653b0ce600000832 GO:0160123 structural constituent of nuclear lamina GO:0006998 nuclear envelope organization GO:0005652 nuclear lamina false UniProtKB:Q2HR75 ORF57 NCBITaxon:868565 653b0ce600001230 KSHV-ORF57 inhibition of host PKR (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001230/653b0ce600001231 GO:0140311 protein sequestering activity GO:0039580 symbiont-mediated suppression of host PKR/eIFalpha signaling GO:0030430 host cell cytoplasm false UniProtKB:P19525 EIF2AK2 Hsap 653b0ce600001230 KSHV-ORF57 inhibition of host PKR (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001230/653b0ce600001235 GO:0004672 protein kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9BY44 EIF2A Hsap 653b0ce600001230 KSHV-ORF57 inhibition of host PKR (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001230/653b0ce600001238 GO:0003743 translation initiation factor activity GO:0006413 translational initiation GO:0005737 cytoplasm false UniProtKB:P20042 EIF2S2 Hsap 653b0ce600001230 KSHV-ORF57 inhibition of host PKR (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001230/653b0ce600001253 GO:0003743 translation initiation factor activity GO:0006413 translational initiation GO:0005737 cytoplasm false UniProtKB:O75569 PRKRA Hsap 653b0ce600001230 KSHV-ORF57 inhibition of host PKR (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001230/653b0ce600001273 GO:0008047 enzyme activator activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q2HR75 ORF57 NCBITaxon:868565 653b0ce600001283 KSHV-ORF57 inhibition of host P-body formation (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001283/653b0ce600001391 GO:0140311 protein sequestering activity GO:1903902 positive regulation of viral life cycle GO:0030430 host cell cytoplasm false UniProtKB:Q9UKV8 AGO2 Hsap 653b0ce600001283 KSHV-ORF57 inhibition of host P-body formation (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001283/653b0ce600001398 GO:0004521 RNA endonuclease activity GO:0033962 P-body assembly GO:0000932 P-body false UniProtKB:Q8NDV7 TNRC6A Hsap 653b0ce600001283 KSHV-ORF57 inhibition of host P-body formation (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001283/653b0ce600001405 GO:0030674 protein-macromolecule adaptor activity GO:0033962 P-body assembly GO:0000932 P-body false UniProtKB:O14862 AIM2 Hsap 653b0ce600001285 KSHV-ORF37 inhibition of host inflammasome activation via AIM2 (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001285/653b0ce600001293 GO:0003690 double-stranded DNA binding GO:0140970 AIM2 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q9ULZ3 PYCARD Hsap 653b0ce600001285 KSHV-ORF37 inhibition of host inflammasome activation via AIM2 (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001285/653b0ce600001371 GO:0030674 protein-macromolecule adaptor activity GO:0044546 NLRP3 inflammasome complex assembly false UniProtKB:Q2HR95 ORF37 NCBITaxon:868565 653b0ce600001285 KSHV-ORF37 inhibition of host inflammasome activation via AIM2 (Human-HHV8) NCBITaxon:9606 gomodel:653b0ce600001285/653b0ce600001381 GO:0140313 molecular sequestering activity GO:0140972 negative regulation of AIM2 inflammasome complex assembly GO:0030430 host cell cytoplasm false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). NCBITaxon:9606 gomodel:654d809000000010/654d809000000011 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). NCBITaxon:9606 gomodel:654d809000000010/654d809000000022 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005829 cytosol false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). NCBITaxon:9606 gomodel:654d809000000010/654d809000000034 GO:0140036 ubiquitin-modified protein reader activity GO:0035973 aggrephagy GO:0005829 cytosol false UniProtKB:Q8WVZ1 ZDHHC19 Hsap 654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). NCBITaxon:9606 gomodel:654d809000000010/654d809000000155 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:1905337 positive regulation of aggrephagy false UniProtKB:O75608 LYPLA1 Hsap 654d809000000010 Regulation of aggrephagy via palmitoylation and depalmitoylation of SQSTM1 by ZDHHC19 and LYPLA1, respectively (Human). NCBITaxon:9606 gomodel:654d809000000010/654d809000000162 GO:0008474 palmitoyl-(protein) hydrolase activity GO:1905336 negative regulation of aggrephagy false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000053 Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). NCBITaxon:9606 gomodel:654d809000000053/654d809000000054 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000053 Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). NCBITaxon:9606 gomodel:654d809000000053/654d809000000065 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005829 cytosol false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000053 Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). NCBITaxon:9606 gomodel:654d809000000053/654d809000000077 GO:0140036 ubiquitin-modified protein reader activity GO:0035973 aggrephagy GO:0005829 cytosol false UniProtKB:Q92993 KAT5 Hsap 654d809000000053 Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). NCBITaxon:9606 gomodel:654d809000000053/654d809000000096 GO:0061733 protein-lysine-acetyltransferase activity GO:1905337 positive regulation of aggrephagy false UniProtKB:Q9UBN7 HDAC6 Hsap 654d809000000053 Regulation of aggrephagy via acetylation and deacetylation of SQSTM1 by KAT5 and HDAC6, respectively (Human). NCBITaxon:9606 gomodel:654d809000000053/654d809000000104 GO:0033558 protein lysine deacetylase activity GO:1905336 negative regulation of aggrephagy false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000112 SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes (Human). NCBITaxon:9606 gomodel:654d809000000112/654d809000000113 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000112 SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes (Human). NCBITaxon:9606 gomodel:654d809000000112/654d809000000124 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005829 cytosol false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000112 SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes (Human). NCBITaxon:9606 gomodel:654d809000000112/654d809000000136 GO:0140036 ubiquitin-modified protein reader activity GO:0035973 aggrephagy GO:0005829 cytosol false GO:0000151 ubiquitin ligase complex 654d809000000112 SQSTM1 is involved in aggrephagy by mediating recruitment of ubiquitinated proteins to autophagosomes (Human). NCBITaxon:9606 gomodel:654d809000000112/654d809000000145 GO:0061630 ubiquitin protein ligase activity GO:1905337 positive regulation of aggrephagy false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000171 SQSTM1 mediates retention of KEAP1 into p62 bodies (Human). NCBITaxon:9606 gomodel:654d809000000171/654d809000000172 GO:0140311 protein sequestering activity GO:0033554 cellular response to stress GO:0005829 cytosol false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000171 SQSTM1 mediates retention of KEAP1 into p62 bodies (Human). NCBITaxon:9606 gomodel:654d809000000171/654d809000000183 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005829 cytosol false UniProtKB:O75385 ULK1 Hsap 654d809000000171 SQSTM1 mediates retention of KEAP1 into p62 bodies (Human). NCBITaxon:9606 gomodel:654d809000000171/654d809000000216 GO:0004674 protein serine/threonine kinase activity GO:0033554 cellular response to stress false UniProtKB:Q14145 KEAP1 Hsap 654d809000000171 SQSTM1 mediates retention of KEAP1 into p62 bodies (Human). NCBITaxon:9606 gomodel:654d809000000171/654d809000000231 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000248 Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human). NCBITaxon:9606 gomodel:654d809000000248/654d809000000249 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000248 Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human). NCBITaxon:9606 gomodel:654d809000000248/654d809000000260 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005829 cytosol false UniProtKB:Q13501 SQSTM1 Hsap 654d809000000248 Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human). NCBITaxon:9606 gomodel:654d809000000248/654d809000000272 GO:0140036 ubiquitin-modified protein reader activity GO:0035973 aggrephagy GO:0005829 cytosol false UniProtKB:P68400 CSNK2A1 Hsap 654d809000000248 Regulation of aggrephagy via phosphorylation of SQSTM1 by CK2 (Human). NCBITaxon:9606 gomodel:654d809000000248/654d809000000291 GO:0004674 protein serine/threonine kinase activity GO:1905337 positive regulation of aggrephagy false UniProtKB:Q9UHD2 TBK1 Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000813 GO:0004674 protein serine/threonine kinase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000823 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q86WV6 STING1 Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000827 GO:0061507 2',3'-cyclic GMP-AMP binding GO:0140896 cGAS/STING signaling pathway GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8N884 CGAS Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000831 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false RNAcentral:URS000012F9EC_9606 hsa-miR-4691-3p Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000836 GO:1903231 mRNA base-pairing post-transcriptional repressor activity GO:0035195 miRNA-mediated post-transcriptional gene silencing GO:0005829 cytosol false UniProtKB:Q14653 IRF3 Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/654d809000000872 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q86WV6 STING1 Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/65692e7e00001150 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q04206 RELA Hsap 654d809000000802 Model of MiR-4691-3p inhibition of cGAS-STING signaling in the cytosol (Human) NCBITaxon:9606 gomodel:654d809000000802/69ea894900004380 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:P50876 RNF144A Hsap 654d809000001411 RNF144A-mediated K6-linked ubiquitination of STING(Human) NCBITaxon:9606 gomodel:654d809000001411/654d809000001412 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q86WV6 STING1 Hsap 654d809000001411 RNF144A-mediated K6-linked ubiquitination of STING(Human) NCBITaxon:9606 gomodel:654d809000001411/654d809000001423 GO:0035591 signaling adaptor activity GO:0002221 pattern recognition receptor signaling pathway GO:0000139 Golgi membrane false UniProtKB:Q9UHD2 TBK1 Hsap 654d809000001411 RNF144A-mediated K6-linked ubiquitination of STING(Human) NCBITaxon:9606 gomodel:654d809000001411/654d809000001435 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13049 TRIM32 Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/654d809000001642 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O96017 CHEK2 Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/654d809000001654 GO:0004674 protein serine/threonine kinase activity GO:2000785 regulation of autophagosome assembly false UniProtKB:O95352 ATG7 Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/654d809000001665 GO:0019778 Atg12 activating enzyme activity GO:0061739 protein lipidation involved in autophagosome assembly false UniProtKB:Q9GZQ8 MAP1LC3B Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/654d809000001678 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q13315 ATM Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/654d809000001894 GO:0004674 protein serine/threonine kinase activity GO:2000785 regulation of autophagosome assembly false UniProtKB:O95352 ATG7 Hsap 654d809000001587 Atg7-mediated autophagosome assembly via ATM-CHK2-TRIM32 axis (Human) NCBITaxon:9606 gomodel:654d809000001587/65692e7e00001485 GO:0019779 Atg8 activating enzyme activity GO:0061739 protein lipidation involved in autophagosome assembly GO:0000407 phagophore assembly site false UniProtKB:Q13315 ATM Hsap 654d809000001692 Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human) NCBITaxon:9606 gomodel:654d809000001692/654d809000001693 GO:0004674 protein serine/threonine kinase activity GO:0006979 response to oxidative stress false UniProtKB:O96017 CHEK2 Hsap 654d809000001692 Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human) NCBITaxon:9606 gomodel:654d809000001692/654d809000001703 GO:0106310 protein serine kinase activity GO:0006979 response to oxidative stress false UniProtKB:O95352 ATG7 Hsap 654d809000001692 Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human) NCBITaxon:9606 gomodel:654d809000001692/654d809000001729 GO:0019778 Atg12 activating enzyme activity GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q13049 TRIM32 Hsap 654d809000001692 Activation of autophagosome assembly by ATM-CHK2-TRIM32-ATG7 axis (Human) NCBITaxon:9606 gomodel:654d809000001692/654d809000001911 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005776 autophagosome false UniProtKB:O75154 RAB11FIP3 Hsap 654d809000002780 Early endosome to recycling endosome transport by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002780/654d809000002781 GO:0030674 protein-macromolecule adaptor activity GO:0032456 endocytic recycling GO:0030666 endocytic vesicle membrane false UniProtKB:P62491 RAB11A Hsap 654d809000002780 Early endosome to recycling endosome transport by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002780/654d809000002794 GO:0003925 G protein activity GO:0032456 endocytic recycling GO:0030666 endocytic vesicle membrane false UniProtKB:Q9Y6G9 DYNC1LI1 Hsap 654d809000002780 Early endosome to recycling endosome transport by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002780/654d809000002812 GO:0030674 protein-macromolecule adaptor activity GO:0007018 microtubule-based movement GO:0005874 microtubule false UniProtKB:O75154 RAB11FIP3 Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00000214 GO:0030674 protein-macromolecule adaptor activity GO:0016192 vesicle-mediated transport GO:0030666 endocytic vesicle membrane false UniProtKB:P62330 ARF6 Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00000445 GO:0003925 G protein activity GO:1905345 protein localization to cleavage furrow GO:0032154 cleavage furrow false UniProtKB:P62491 RAB11A Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00000942 GO:0003925 G protein activity GO:0016192 vesicle-mediated transport GO:0030666 endocytic vesicle membrane false UniProtKB:Q9H0H5 RACGAP1 Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00001063 GO:0030674 protein-macromolecule adaptor activity GO:0000281 mitotic cytokinesis GO:0030496 midbody false UniProtKB:Q9UPT5 EXOC7 Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00001082 GO:0030674 protein-macromolecule adaptor activity GO:0006904 obsolete vesicle docking involved in exocytosis GO:0032154 cleavage furrow false UniProtKB:Q9H8V3 ECT2 Hsap 654d809000002825 Regulation of endosomal membrane tethering to cleavage furrow during cytokinesis by the FIP3-Rab11 complex (Human) NCBITaxon:9606 gomodel:654d809000002825/65692e7e00001102 GO:0005085 guanyl-nucleotide exchange factor activity GO:1903438 positive regulation of mitotic cytokinetic process GO:0030496 midbody false UniProtKB:P32455 GBP1 Hsap 65692e7e00000049 GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human). NCBITaxon:9606 gomodel:65692e7e00000049/65692e7e00000063 GO:0003924 GTPase activity GO:0051715 cytolysis in another organism GO:0031410 cytoplasmic vesicle false UniProtKB:P49662 CASP4 Hsap 65692e7e00000049 GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human). NCBITaxon:9606 gomodel:65692e7e00000049/65692e7e00000073 GO:0008289 lipid binding GO:0160075 non-canonical inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 65692e7e00000049 GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human). NCBITaxon:9606 gomodel:65692e7e00000049/65692e7e00000082 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P32455 GBP1 Hsap 65692e7e00000049 GBP1 GTPase promotes assembly of the non-canonical inflammasome via association with lipopolysaccharide (Human). NCBITaxon:9606 gomodel:65692e7e00000049/65692e7e00000094 GO:0001530 lipopolysaccharide binding GO:0160075 non-canonical inflammasome complex assembly GO:0031410 cytoplasmic vesicle false UniProtKB:P32455 GBP1 Hsap 65692e7e00000115 PIM1 inhibits the innate immune response by promoting cytosolic retention of GBP1 (Human). NCBITaxon:9606 gomodel:65692e7e00000115/65692e7e00000116 GO:0003924 GTPase activity GO:0051715 cytolysis in another organism GO:0031410 cytoplasmic vesicle false UniProtKB:P11309 PIM1 Hsap 65692e7e00000115 PIM1 inhibits the innate immune response by promoting cytosolic retention of GBP1 (Human). NCBITaxon:9606 gomodel:65692e7e00000115/65692e7e00000161 GO:0004674 protein serine/threonine kinase activity GO:0045824 negative regulation of innate immune response false UniProtKB:P31947 SFN Hsap 65692e7e00000115 PIM1 inhibits the innate immune response by promoting cytosolic retention of GBP1 (Human). NCBITaxon:9606 gomodel:65692e7e00000115/65692e7e00000168 GO:0140311 protein sequestering activity GO:0045824 negative regulation of innate immune response GO:0005829 cytosol false UniProtKB:Q7L523 RRAGA Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000244 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000261 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false GO:0140007 KICSTOR complex 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000387 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q8WTW4 NPRL2 Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000398 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q1RMZ1 SAMTOR Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000436 GO:1904047 S-adenosyl-L-methionine binding GO:1904263 positive regulation of TORC1 signaling false UniProtKB:Q99873 PRMT1 Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000473 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0061431 cellular response to methionine GO:0005765 lysosomal membrane false UniProtKB:P31153 MAT2A Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00000566 GO:0004478 methionine adenosyltransferase activity GO:1904263 positive regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 65692e7e00000243 Activation of the canonical mTORC1 signaling by PRMT1 in response to S-adenosyl-L-methionine influx (Human) NCBITaxon:9606 gomodel:65692e7e00000243/65692e7e00001138 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q92633 LPAR1 Hsap 65692e7e00001241 Negative regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by WDR44 (Human) NCBITaxon:9606 gomodel:65692e7e00001241/65692e7e00001245 GO:0070915 lysophosphatidic acid receptor activity GO:1902018 negative regulation of cilium assembly GO:0005886 plasma membrane false UniProtKB:Q5JSH3 WDR44 Hsap 65692e7e00001241 Negative regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by WDR44 (Human) NCBITaxon:9606 gomodel:65692e7e00001241/65692e7e00001253 GO:0140313 molecular sequestering activity GO:0060627 regulation of vesicle-mediated transport GO:0010008 endosome membrane false UniProtKB:P31749 AKT1 Hsap 65692e7e00001241 Negative regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by WDR44 (Human) NCBITaxon:9606 gomodel:65692e7e00001241/65692e7e00001264 GO:0004674 protein serine/threonine kinase activity GO:1902018 negative regulation of cilium assembly false UniProtKB:O75154 RAB11FIP3 Hsap 65692e7e00001241 Negative regulation of the Rab11-Rab8-Rabin8 cascade-mediated preciliary trafficking by WDR44 (Human) NCBITaxon:9606 gomodel:65692e7e00001241/65692e7e00001273 GO:0030674 protein-macromolecule adaptor activity GO:0043001 Golgi to plasma membrane protein transport GO:0000139 Golgi membrane false UniProtKB:Q16552 IL17A Hsap 65692e7e00001542 Inhibition of IL17 signaling by USP25 via TRAF6 (Human) NCBITaxon:9606 gomodel:65692e7e00001542/65692e7e00001544 GO:0005125 cytokine activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:O43734 TRAF3IP2 Hsap 65692e7e00001542 Inhibition of IL17 signaling by USP25 via TRAF6 (Human) NCBITaxon:9606 gomodel:65692e7e00001542/65692e7e00001567 GO:0061630 ubiquitin protein ligase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 65692e7e00001542 Inhibition of IL17 signaling by USP25 via TRAF6 (Human) NCBITaxon:9606 gomodel:65692e7e00001542/65692e7e00001583 GO:0061630 ubiquitin protein ligase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 65692e7e00001542 Inhibition of IL17 signaling by USP25 via TRAF6 (Human) NCBITaxon:9606 gomodel:65692e7e00001542/65692e7e00001587 GO:0004674 protein serine/threonine kinase activity GO:0038173 interleukin-17A-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9UHP3 USP25 Hsap 65692e7e00001542 Inhibition of IL17 signaling by USP25 via TRAF6 (Human) NCBITaxon:9606 gomodel:65692e7e00001542/65692e7e00001613 GO:0101005 deubiquitinase activity GO:1903882 negative regulation of interleukin-17-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14145 KEAP1 Hsap 65692e7e00001784 USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human) NCBITaxon:9606 gomodel:65692e7e00001784/65692e7e00001785 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:1902883 negative regulation of response to oxidative stress GO:0005737 cytoplasm false UniProtKB:Q9UHP3 USP25 Hsap 65692e7e00001784 USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human) NCBITaxon:9606 gomodel:65692e7e00001784/65692e7e00001792 GO:0101005 deubiquitinase activity GO:1902883 negative regulation of response to oxidative stress GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 65692e7e00001784 USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human) NCBITaxon:9606 gomodel:65692e7e00001784/65692e7e00001799 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q16236 NFE2L2 Hsap 65692e7e00001784 USP25-mediated stabilization of KEAP1 leading to NRF2 degradation (Human) NCBITaxon:9606 gomodel:65692e7e00001784/65692e7e00001807 GO:0003700 DNA-binding transcription factor activity GO:0034599 cellular response to oxidative stress GO:0005634 nucleus false UniProtKB:P31749 AKT1 Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/65692e7e00001823 GO:0004674 protein serine/threonine kinase activity GO:0060079 excitatory postsynaptic potential GO:0016020 membrane false UniProtKB:P62258 YWHAE Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/65692e7e00001830 GO:0035591 signaling adaptor activity GO:0070972 protein localization to endoplasmic reticulum GO:0005783 endoplasmic reticulum false UniProtKB:Q9Y4L5 RNF115 Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/657ba49f00000074 GO:0061630 ubiquitin protein ligase activity GO:0070979 protein K11-linked ubiquitination GO:0005783 endoplasmic reticulum false UniProtKB:P31150 GDI1 Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/657ba49f00000094 GO:0005092 GDP-dissociation inhibitor activity GO:0034123 positive regulation of toll-like receptor signaling pathway GO:0005783 endoplasmic reticulum false UniProtKB:P62820 RAB1A Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/657ba49f00000106 GO:0003924 GTPase activity GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport GO:0005783 endoplasmic reticulum false UniProtKB:P51153 RAB13 Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/657ba49f00000114 GO:0003924 GTPase activity GO:0006893 Golgi to plasma membrane transport GO:0005794 Golgi apparatus false UniProtKB:O00206 TLR4 Hsap 65692e7e00001822 RNF115 inhibition of TLR transport to cell surface (Human) NCBITaxon:9606 gomodel:65692e7e00001822/657ba49f00000122 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P30043 BLVRB Hsap 65692e7e00002024 BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). NCBITaxon:9606 gomodel:65692e7e00002024/65692e7e00002025 GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0046627 negative regulation of insulin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P30043 BLVRB Hsap 65692e7e00002024 BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). NCBITaxon:9606 gomodel:65692e7e00002024/65692e7e00002034 GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0046627 negative regulation of insulin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P06213 INSR Hsap 65692e7e00002024 BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). NCBITaxon:9606 gomodel:65692e7e00002024/65692e7e00002043 GO:0004713 protein tyrosine kinase activity GO:0008286 insulin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P01308 INS Hsap 65692e7e00002024 BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). NCBITaxon:9606 gomodel:65692e7e00002024/65692e7e00002053 GO:0005179 hormone activity GO:0008286 insulin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P35568 IRS1 Hsap 65692e7e00002024 BLVRB negatively regulates insulin signaling by mediating S-nitrosylation of INSR and IRS1 (Human). NCBITaxon:9606 gomodel:65692e7e00002024/65692e7e00002061 GO:0035591 signaling adaptor activity GO:0008286 insulin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9BXM7 PINK1 Hsap 657ba49f00000136 PINK1 role in mitophagy (Human) NCBITaxon:9606 gomodel:657ba49f00000136/657ba49f00000137 GO:0004674 protein serine/threonine kinase activity GO:0000423 mitophagy GO:0005739 mitochondrion false UniProtKB:Q9UNA1 ARHGAP26 Hsap 657ba49f00000136 PINK1 role in mitophagy (Human) NCBITaxon:9606 gomodel:657ba49f00000136/657ba49f00000145 GO:0030674 protein-macromolecule adaptor activity GO:0000423 mitophagy GO:0005739 mitochondrion false UniProtKB:Q9NYB9 ABI2 Hsap 657ba49f00000136 PINK1 role in mitophagy (Human) NCBITaxon:9606 gomodel:657ba49f00000136/657ba49f00000152 GO:0008093 cytoskeletal adaptor activity GO:0000423 mitophagy GO:0005737 cytoplasm false UniProtKB:Q4AE62 QTMAN Hsap 657ba49f00001143 tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). NCBITaxon:9606 gomodel:657ba49f00001143/657ba49f00001144 GO:0016438 tRNA-queuosine(34) beta-mannosyltransferase activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:Q67FW5 QTGAL Hsap 657ba49f00001143 tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). NCBITaxon:9606 gomodel:657ba49f00001143/657ba49f00001151 GO:0141125 tRNA-queuosine(34) galactosyltransferase activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:Q9BXR0 QTRT1 Hsap 657ba49f00001143 tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). NCBITaxon:9606 gomodel:657ba49f00001143/657ba49f00001158 GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:Q9H974 QTRT2 Hsap 657ba49f00001143 tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). NCBITaxon:9606 gomodel:657ba49f00001143/657ba49f00001163 GO:0140767 enzyme-substrate adaptor activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:O14717 TRDMT1 Hsap 657ba49f00001143 tRNA queuosine promotes further glycosylation by GTDC1 and B3GNTL1, and methylation by TRDMT1 (Human). NCBITaxon:9606 gomodel:657ba49f00001143/657ba49f00001174 GO:0016428 tRNA (cytidine-N5)-methyltransferase activity GO:0006400 tRNA modification GO:0005737 cytoplasm false UniProtKB:O76090 BEST1 Hsap 657ba49f00001182 astrocytic Best1-mediated glutamate on postsynaptic NMDARs upon PAR-1 activation (Human) NCBITaxon:9606 gomodel:657ba49f00001182/657ba49f00001183 GO:0022834 ligand-gated channel activity GO:0014047 glutamate secretion GO:0098857 membrane microdomain false UniProtKB:P25116 F2R Hsap 657ba49f00001182 astrocytic Best1-mediated glutamate on postsynaptic NMDARs upon PAR-1 activation (Human) NCBITaxon:9606 gomodel:657ba49f00001182/657ba49f00001439 GO:0015057 thrombin-activated receptor activity GO:0070493 thrombin-activated receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q12879 GRIN2A Hsap 657ba49f00001182 astrocytic Best1-mediated glutamate on postsynaptic NMDARs upon PAR-1 activation (Human) NCBITaxon:9606 gomodel:657ba49f00001182/657ba49f00001626 GO:0004972 NMDA glutamate receptor activity GO:0070493 thrombin-activated receptor signaling pathway GO:0045211 postsynaptic membrane false UniProtKB:Q9UPT9 USP22 Hsap 657ba49f00001888 CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human) NCBITaxon:9606 gomodel:657ba49f00001888/657ba49f00001897 GO:0004843 cysteine-type deubiquitinase activity GO:0016579 protein deubiquitination GO:0005634 nucleus false UniProtKB:P14635 CCNB1 Hsap 657ba49f00001888 CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human) NCBITaxon:9606 gomodel:657ba49f00001888/657ba49f00001902 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000086 G2/M transition of mitotic cell cycle GO:0005634 nucleus false UniProtKB:P06493 CDK1 Hsap 657ba49f00001888 CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human) NCBITaxon:9606 gomodel:657ba49f00001888/657ba49f00001911 GO:0004674 protein serine/threonine kinase activity GO:0000086 G2/M transition of mitotic cell cycle GO:0005634 nucleus false UniProtKB:Q12834 CDC20 Hsap 657ba49f00001888 CDK1-mediated deubiquitination of CCNB1 by USP22 leading to G2/M progression (Human) NCBITaxon:9606 gomodel:657ba49f00001888/657ba49f00001928 GO:1990756 ubiquitin-like ligase-substrate adaptor activity false UniProtKB:Q70CQ1 USP49 Hsap 65a1f4f800000029 USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) NCBITaxon:9606 gomodel:65a1f4f800000029/65a1f4f800000030 GO:0004843 cysteine-type deubiquitinase activity GO:0016579 protein deubiquitination GO:0005737 cytoplasm false UniProtKB:Q13451 FKBP5 Hsap 65a1f4f800000029 USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) NCBITaxon:9606 gomodel:65a1f4f800000029/65a1f4f800000037 GO:0030674 protein-macromolecule adaptor activity GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005737 cytoplasm false UniProtKB:P31749 AKT1 Hsap 65a1f4f800000029 USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) NCBITaxon:9606 gomodel:65a1f4f800000029/65a1f4f800000043 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005737 cytoplasm false UniProtKB:O60346 PHLPP1 Hsap 65a1f4f800000029 USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) NCBITaxon:9606 gomodel:65a1f4f800000029/65a1f4f800000050 GO:0004722 protein serine/threonine phosphatase activity GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NRC8 SIRT7 Hsap 65a1f4f800000029 USP49 and SIRT7 inhibition of AKT1 via PHLPP1-mediated dephosphorylation of AKT1 (Human) NCBITaxon:9606 gomodel:65a1f4f800000029/65a1f4f800000083 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005737 cytoplasm false UniProtKB:Q13315 ATM Hsap 65a1f4f800000391 Phosphorylation of RAD17 by ATM promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000391/65a1f4f800000392 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:O75943 RAD17 Hsap 65a1f4f800000391 Phosphorylation of RAD17 by ATM promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000391/65a1f4f800000407 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:O60934 NBN Hsap 65a1f4f800000391 Phosphorylation of RAD17 by ATM promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000391/65a1f4f800000417 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:P68400 CSNK2A1 Hsap 65a1f4f800000428 Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000428/65a1f4f800000429 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:O60934 NBN Hsap 65a1f4f800000428 Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000428/65a1f4f800000439 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q14676 MDC1 Hsap 65a1f4f800000428 Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000428/65a1f4f800000452 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q14676 MDC1 Hsap 65a1f4f800000428 Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000428/65a1f4f800000472 GO:0140566 histone reader activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000428 Phosphorylation of MDC1 by CK2 promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000428/65a1f4f800000480 GO:0035979 histone H2AXS139 kinase activity GO:0006974 DNA damage response false UniProtKB:Q13535 ATR Hsap 65a1f4f800000487 Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000487/65a1f4f800000488 GO:0035979 histone H2AXS139 kinase activity GO:0006974 DNA damage response false UniProtKB:P16104 H2AX Hsap 65a1f4f800000487 Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000487/65a1f4f800000527 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:O60934 NBN Hsap 65a1f4f800000487 Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000487/65a1f4f800000536 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000487 Phosphorylation of H2AX by ATM or ATR promotes recruitment of NBN and MRN complex to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800000487/65a1f4f800000547 GO:0035979 histone H2AXS139 kinase activity GO:0006974 DNA damage response false UniProtKB:Q96FA3 PELI1 Hsap 65a1f4f800000553 Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800000553/65a1f4f800000554 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000553 Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800000553/65a1f4f800000565 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:Q13315 ATM Hsap 65a1f4f800000553 Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800000553/65a1f4f800000573 GO:0035979 histone H2AXS139 kinase activity GO:0006974 DNA damage response false UniProtKB:P16104 H2AX Hsap 65a1f4f800000553 Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800000553/65a1f4f800000578 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:O60934 NBN Hsap 65a1f4f800000553 Ubiquitination of NBN by PELI1 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800000553/65a1f4f800000589 GO:0140463 chromatin-protein adaptor activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000673 Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000673/65a1f4f800000674 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q70EK9 USP51 Hsap 65a1f4f800000673 Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000673/65a1f4f800000686 GO:0004843 cysteine-type deubiquitinase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q8WYQ5 DGCR8 Hsap 65a1f4f800000673 Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000673/65a1f4f800000696 GO:0030674 protein-macromolecule adaptor activity GO:0006974 DNA damage response GO:0035861 site of double-strand break false UniProtKB:Q8IYW5 RNF168 Hsap 65a1f4f800000673 Role of USP51 in DNA damage response via DGCR8 deubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000673/65a1f4f800000708 GO:0140852 histone ubiquitin ligase activity GO:0006974 DNA damage response GO:0035861 site of double-strand break false UniProtKB:O60934 NBN Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000873 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false GO:0030870 Mre11 complex 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000890 GO:0043539 protein serine/threonine kinase activator activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000902 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000913 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000971 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000979 GO:0004520 DNA endonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92878 RAD50 Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000987 GO:0016887 ATP hydrolysis activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9UQ84 EXO1 Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800000992 GO:0035312 5'-3' DNA exonuclease activity GO:0110025 DNA strand resection involved in replication fork processing false UniProtKB:Q13315 ATM Hsap 65a1f4f800000855 Initiation of double-strand break repair via homologous recombination by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800000855/65a1f4f800002009 GO:0004674 protein serine/threonine kinase activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92574 TSC1 Hsap 65a1f4f800000922 PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000922/65a1f4f800000923 GO:0044183 protein folding chaperone GO:1904262 negative regulation of TORC1 signaling GO:0005737 cytoplasm false UniProtKB:Q96FA3 PELI1 Hsap 65a1f4f800000922 PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000922/65a1f4f800000930 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P49815 TSC2 Hsap 65a1f4f800000922 PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000922/65a1f4f800000942 GO:0005096 GTPase activator activity GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 65a1f4f800000922 PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000922/65a1f4f800000955 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 65a1f4f800000922 PELI1 negative regulation of MTOR pathway via TSC1 ubiquitination (Human) NCBITaxon:9606 gomodel:65a1f4f800000922/65a1f4f800000963 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O60934 NBN Hsap 65a1f4f800001029 SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001029/65a1f4f800001033 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false GO:0030870 Mre11 complex 65a1f4f800001029 SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001029/65a1f4f800001042 GO:0043539 protein serine/threonine kinase activator activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800001029 SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001029/65a1f4f800001065 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13309 SKP2 Hsap 65a1f4f800001029 SKP2 mediates 'Lys-63'-linked ubiquitination of NBN, promoting double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001029/65a1f4f800001117 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:O60934 NBN Hsap 65a1f4f800001127 Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001127/65a1f4f800001138 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q14676 MDC1 Hsap 65a1f4f800001127 Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001127/65a1f4f800001151 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:O76064 RNF8 Hsap 65a1f4f800001127 Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001127/65a1f4f800001191 GO:0061630 ubiquitin protein ligase activity GO:0085020 protein K6-linked ubiquitination GO:0035861 site of double-strand break false UniProtKB:Q14676 MDC1 Hsap 65a1f4f800001127 Ubiquitination of NBN by RNF8 promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001127/65a1f4f800001202 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false GO:0030870 Mre11 complex 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001256 GO:0043539 protein serine/threonine kinase activator activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001268 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001288 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001296 GO:0004520 DNA endonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001331 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:Q92793 CREBBP Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/65a1f4f800001338 GO:0120300 peptide lactyltransferase (CoA-dependent) activity GO:1905168 positive regulation of double-strand break repair via homologous recombination false UniProtKB:O60934 NBN Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/66c7d41500001327 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q92993 KAT5 Hsap 65a1f4f800001246 Lactylation of MRE11 by CREBBP and NBN by KAT5 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001246/66c7d41500001342 GO:0120300 peptide lactyltransferase (CoA-dependent) activity GO:1905168 positive regulation of double-strand break repair via homologous recombination false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001422 GO:0008296 3'-5'-DNA exonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001430 GO:0004520 DNA endonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:O60934 NBN Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001449 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q99708 RBBP8 Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001465 GO:0000014 single-stranded DNA endonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:Q13535 ATR Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001513 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:P06493 CDK1 Hsap 65a1f4f800001380 RBBP8/CtIP stimulates the endonuclease activity of MRE11 following phosphorylation by ATR and CDK1 (Human). NCBITaxon:9606 gomodel:65a1f4f800001380/65a1f4f800001521 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001566 Methylation of MRE11 by PRMT1 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001566/65a1f4f800001588 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q99873 PRMT1 Hsap 65a1f4f800001566 Methylation of MRE11 by PRMT1 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001566/65a1f4f800001636 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0006974 DNA damage response false UniProtKB:Q99684 GFI1 Hsap 65a1f4f800001566 Methylation of MRE11 by PRMT1 in response to DNA damage promotes double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001566/65a1f4f800001650 GO:0140767 enzyme-substrate adaptor activity GO:0006974 DNA damage response false UniProtKB:Q99873 PRMT1 Hsap 65a1f4f800001668 Methylation of TP53BP1 by PRMT1 in response to DNA damage promotes double-strand break repair via nonhomologous end joining (Human). NCBITaxon:9606 gomodel:65a1f4f800001668/65a1f4f800001685 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity GO:0006974 DNA damage response false UniProtKB:Q99684 GFI1 Hsap 65a1f4f800001668 Methylation of TP53BP1 by PRMT1 in response to DNA damage promotes double-strand break repair via nonhomologous end joining (Human). NCBITaxon:9606 gomodel:65a1f4f800001668/65a1f4f800001701 GO:0140767 enzyme-substrate adaptor activity GO:0006974 DNA damage response false UniProtKB:Q12888 TP53BP1 Hsap 65a1f4f800001668 Methylation of TP53BP1 by PRMT1 in response to DNA damage promotes double-strand break repair via nonhomologous end joining (Human). NCBITaxon:9606 gomodel:65a1f4f800001668/65a1f4f800001716 GO:0003712 transcription coregulator activity GO:2000042 negative regulation of double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001740 Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001740/65a1f4f800001782 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800001740 Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001740/65a1f4f800001790 GO:0004520 DNA endonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P53350 PLK1 Hsap 65a1f4f800001740 Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001740/65a1f4f800001824 GO:0004674 protein serine/threonine kinase activity GO:2000042 negative regulation of double-strand break repair via homologous recombination false UniProtKB:P68400 CSNK2A1 Hsap 65a1f4f800001740 Phosphorylation of MRE11 by PLK1 and CK2 inhibits double-strand break repair via homologous recombination (Human). NCBITaxon:9606 gomodel:65a1f4f800001740/65a1f4f800001831 GO:0004674 protein serine/threonine kinase activity GO:2000042 negative regulation of double-strand break repair via homologous recombination false UniProtKB:P49959 MRE11 Hsap 65a1f4f800002022 Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). NCBITaxon:9606 gomodel:65a1f4f800002022/65a1f4f800002064 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9UQ84 EXO1 Hsap 65a1f4f800002022 Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). NCBITaxon:9606 gomodel:65a1f4f800002022/65a1f4f800002085 GO:0035312 5'-3' DNA exonuclease activity GO:0110025 DNA strand resection involved in replication fork processing false UniProtKB:Q9BV68 RNF126 Hsap 65a1f4f800002022 Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). NCBITaxon:9606 gomodel:65a1f4f800002022/65a1f4f800002120 GO:0061630 ubiquitin protein ligase activity GO:0035519 protein K29-linked ubiquitination false UniProtKB:Q9BV68 RNF126 Hsap 65a1f4f800002022 Ubiquitination of MRE11 by RNF126 promotes its exonuclease activity (Human). NCBITaxon:9606 gomodel:65a1f4f800002022/65a1f4f800002129 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination false UniProtKB:P49959 MRE11 Hsap 65a1f4f800002142 DYNLL1 binds to MRE11 to limit DNA end resection (Human). NCBITaxon:9606 gomodel:65a1f4f800002142/65a1f4f800002143 GO:0008296 3'-5'-DNA exonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800002142 DYNLL1 binds to MRE11 to limit DNA end resection (Human). NCBITaxon:9606 gomodel:65a1f4f800002142/65a1f4f800002151 GO:0004520 DNA endonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:P63167 DYNLL1 Hsap 65a1f4f800002142 DYNLL1 binds to MRE11 to limit DNA end resection (Human). NCBITaxon:9606 gomodel:65a1f4f800002142/65a1f4f800002207 GO:0004857 enzyme inhibitor activity GO:0110027 negative regulation of DNA strand resection involved in replication fork processing GO:0035861 site of double-strand break false UniProtKB:Q12888 TP53BP1 Hsap 65a1f4f800002142 DYNLL1 binds to MRE11 to limit DNA end resection (Human). NCBITaxon:9606 gomodel:65a1f4f800002142/65a1f4f800002238 GO:0140566 histone reader activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false UniProtKB:Q96P20 NLRP3 Hsap 65a1f4f800002257 ZDHHC5-mediated palmitoylation of NLRP3 activates inflammasome assembly (Human) NCBITaxon:9606 gomodel:65a1f4f800002257/65a1f4f800002268 GO:0030674 protein-macromolecule adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q8TDX7 NEK7 Hsap 65a1f4f800002257 ZDHHC5-mediated palmitoylation of NLRP3 activates inflammasome assembly (Human) NCBITaxon:9606 gomodel:65a1f4f800002257/65a1f4f800002277 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q9C0B5 ZDHHC5 Hsap 65a1f4f800002257 ZDHHC5-mediated palmitoylation of NLRP3 activates inflammasome assembly (Human) NCBITaxon:9606 gomodel:65a1f4f800002257/65a1f4f800002289 GO:0016409 palmitoyltransferase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly false UniProtKB:Q96GS6 ABHD17A Hsap 65a1f4f800002257 ZDHHC5-mediated palmitoylation of NLRP3 activates inflammasome assembly (Human) NCBITaxon:9606 gomodel:65a1f4f800002257/65a1f4f800002297 GO:0008474 palmitoyl-(protein) hydrolase activity GO:1900226 negative regulation of NLRP3 inflammasome complex assembly false UniProtKB:Q13315 ATM Hsap 65a1f4f800002442 MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). NCBITaxon:9606 gomodel:65a1f4f800002442/65a1f4f800002443 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800002442 MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). NCBITaxon:9606 gomodel:65a1f4f800002442/65a1f4f800002452 GO:0008296 3'-5'-DNA exonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P49959 MRE11 Hsap 65a1f4f800002442 MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). NCBITaxon:9606 gomodel:65a1f4f800002442/65a1f4f800002460 GO:0004520 DNA endonuclease activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q07021 C1QBP Hsap 65a1f4f800002442 MRE11 phosphorylation by ATM dissociates MRE11 from C1QBP inhibitor (Human). NCBITaxon:9606 gomodel:65a1f4f800002442/65a1f4f800002472 GO:0004857 enzyme inhibitor activity GO:2000042 negative regulation of double-strand break repair via homologous recombination false UniProtKB:O60934 NBN Hsap 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002561 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false GO:0030870 Mre11 complex 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002570 GO:0043539 protein serine/threonine kinase activator activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002582 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002593 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002645 GO:0004674 protein serine/threonine kinase activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:O94874 UFL1 Hsap 65a1f4f800002560 Ufmylation of MRE11 promotes ATM activation by the MRN complex (MRE11-RAD50-NBN) (Human). NCBITaxon:9606 gomodel:65a1f4f800002560/65a1f4f800002657 GO:0061666 UFM1 ligase activity GO:0006974 DNA damage response false UniProtKB:O60934 NBN Hsap 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002666 GO:0140463 chromatin-protein adaptor activity GO:1990166 protein localization to site of double-strand break GO:0035861 site of double-strand break false GO:0030870 Mre11 complex 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002675 GO:0043539 protein serine/threonine kinase activator activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002687 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002698 GO:0004674 protein serine/threonine kinase activity GO:0000729 DNA double-strand break processing GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002712 GO:0004674 protein serine/threonine kinase activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:O75925 PIAS1 Hsap 65a1f4f800002665 Sumoylation of MRE11 by PIAS1 promotes retention of the MRN complex (MRE11-RAD50-NBN) to DNA damage sites (Human). NCBITaxon:9606 gomodel:65a1f4f800002665/65a1f4f800002731 GO:0061665 SUMO ligase activity GO:0006974 DNA damage response false UniProtKB:Q9NR96 TLR9 Hsap 65a1f4f800002740 Regulation of TLR9 by palmitoylation (Human) NCBITaxon:9606 gomodel:65a1f4f800002740/65a1f4f800002741 GO:0038187 pattern recognition receptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0031901 early endosome membrane false UniProtKB:Q9NYG2 ZDHHC3 Hsap 65a1f4f800002740 Regulation of TLR9 by palmitoylation (Human) NCBITaxon:9606 gomodel:65a1f4f800002740/65a1f4f800002748 GO:0016409 palmitoyltransferase activity GO:0034165 positive regulation of toll-like receptor 9 signaling pathway GO:0005794 Golgi apparatus false UniProtKB:P50897 PPT1 Hsap 65a1f4f800002740 Regulation of TLR9 by palmitoylation (Human) NCBITaxon:9606 gomodel:65a1f4f800002740/65a1f4f800002758 GO:0008474 palmitoyl-(protein) hydrolase activity GO:0034164 negative regulation of toll-like receptor 9 signaling pathway GO:0005765 lysosomal membrane false UniProtKB:Q9H1C4 UNC93B1 Hsap 65a1f4f800002740 Regulation of TLR9 by palmitoylation (Human) NCBITaxon:9606 gomodel:65a1f4f800002740/65a1f4f800002766 GO:0035325 Toll-like receptor binding GO:0034162 toll-like receptor 9 signaling pathway false UniProtKB:O60934 NBN Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002885 GO:0140463 chromatin-protein adaptor activity GO:0097681 double-strand break repair via alternative nonhomologous end joining GO:0000781 chromosome, telomeric region false UniProtKB:P62136 PPP1CA Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002894 GO:0004722 protein serine/threonine phosphatase activity GO:0043247 telomere maintenance in response to DNA damage false UniProtKB:Q15554 TERF2 Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002904 GO:0003691 double-stranded telomeric DNA binding GO:0000723 telomere maintenance GO:0000781 chromosome, telomeric region false UniProtKB:O60934 NBN Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002912 GO:0140463 chromatin-protein adaptor activity GO:0031848 protection from non-homologous end joining at telomere GO:0000781 chromosome, telomeric region false UniProtKB:Q15554 TERF2 Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002921 GO:0003691 double-stranded telomeric DNA binding GO:0000723 telomere maintenance GO:0000781 chromosome, telomeric region false UniProtKB:P24941 CDK2 Hsap 65a1f4f800002884 Phosphorylation of NBN regulates DNA repair choice at telomes (Human). NCBITaxon:9606 gomodel:65a1f4f800002884/65a1f4f800002929 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0043247 telomere maintenance in response to DNA damage false UniProtKB:Q9HCU5 PREB Hsap 65a1f4f800002943 Lipoprotein cargo loading in COPII-mediated ER to Golgi transport (Human) NCBITaxon:9606 gomodel:65a1f4f800002943/65a1f4f800002969 GO:0005085 guanyl-nucleotide exchange factor activity GO:0048208 COPII vesicle coat assembly GO:0070971 endoplasmic reticulum exit site false UniProtKB:Q9Y6B6 SAR1B Hsap 65a1f4f800002943 Lipoprotein cargo loading in COPII-mediated ER to Golgi transport (Human) NCBITaxon:9606 gomodel:65a1f4f800002943/65a1f4f800003134 GO:0003925 G protein activity GO:0090110 COPII-coated vesicle cargo loading GO:0070971 endoplasmic reticulum exit site false UniProtKB:O15260 SURF4 Hsap 65a1f4f800002943 Lipoprotein cargo loading in COPII-mediated ER to Golgi transport (Human) NCBITaxon:9606 gomodel:65a1f4f800002943/65a1f4f800003148 GO:0097020 COPII receptor activity GO:0090110 COPII-coated vesicle cargo loading GO:0070971 endoplasmic reticulum exit site false UniProtKB:Q13188 STK3 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003392 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13043 STK4 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003403 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q8IX03 WWC1 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003429 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95835 LATS1 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003458 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003479 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937 YAP1 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003516 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q9GZV5 WWTR1 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65a1f4f800003533 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q7L9L4 MOB1B Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65bc474400000238 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H8S9 MOB1A Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65bc474400000249 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65a1f4f800003391 Hippo signaling core components (Human). NCBITaxon:9606 gomodel:65a1f4f800003391/65d7e4ac00000490 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13188 STK3 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003543 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003565 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q6AWC2 WWC2 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003578 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003604 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937-2 YAP1 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003619 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:P31946 YWHAB Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800003748 GO:0140311 protein sequestering activity GO:0042308 negative regulation of protein import into nucleus GO:0005737 cytoplasm false UniProtKB:P35240 NF2 Hsap 65a1f4f800003542 Cell contact inhibition by Hippo signaling (Human). NCBITaxon:9606 gomodel:65a1f4f800003542/65a1f4f800004017 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13188 STK3 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003761 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13043 STK4 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003772 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003783 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q8IX03 WWC1 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003796 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95835 LATS1 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003811 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003822 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9GZV5 WWTR1 Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003854 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:P62258 YWHAE Hsap 65a1f4f800003760 Hippo signaling positive regulation by TAZ cytoplasmic retention (Human). NCBITaxon:9606 gomodel:65a1f4f800003760/65a1f4f800003863 GO:0140311 protein sequestering activity GO:0042308 negative regulation of protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q9NPG8 ZDHHC4 Hsap 65bc474400000029 ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) NCBITaxon:9606 gomodel:65bc474400000029/65bc474400000030 GO:0016409 palmitoyltransferase activity GO:0045089 positive regulation of innate immune response GO:0005783 endoplasmic reticulum false UniProtKB:Q7Z434 MAVS Hsap 65bc474400000029 ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) NCBITaxon:9606 gomodel:65bc474400000029/65bc474400000037 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:P50416 CPT1A Hsap 65bc474400000029 ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) NCBITaxon:9606 gomodel:65bc474400000029/65bc474400000047 GO:0030674 protein-macromolecule adaptor activity GO:0045089 positive regulation of innate immune response GO:0005741 mitochondrial outer membrane true carnitine_shuttle UniProtKB:Q9Y228 TRAF3IP3 Hsap 65bc474400000029 ZDHHC4-mediated palmitoylation of MAVS via CPT1A (Human) NCBITaxon:9606 gomodel:65bc474400000029/65bc474400000058 GO:0030674 protein-macromolecule adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:P49841 GSK3B Hsap 65bc474400000069 Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:65bc474400000069/65bc474400000073 GO:0004674 protein serine/threonine kinase activity GO:0030336 negative regulation of cell migration GO:0005737 cytoplasm false UniProtKB:Q15910 EZH2 Hsap 65bc474400000069 Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:65bc474400000069/65bc474400000081 GO:0042054 histone methyltransferase activity GO:0030335 positive regulation of cell migration GO:0005694 chromosome false UniProtKB:P31749 AKT1 Hsap 65bc474400000069 Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:65bc474400000069/65bc474400000087 GO:0004674 protein serine/threonine kinase activity GO:0030335 positive regulation of cell migration GO:0005737 cytoplasm false UniProtKB:Q9NPG8 ZDHHC4 Hsap 65bc474400000069 Regulation of GSK3B phosphorylation by ZDHHC4-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:65bc474400000069/65bc474400000095 GO:0016409 palmitoyltransferase activity GO:0005783 endoplasmic reticulum false UniProtKB:Q13188 STK3 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000270 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13043 STK4 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000281 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000292 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q6AWC2 WWC2 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000305 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95835 LATS1 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000318 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000329 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937 YAP1 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000344 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q9GZV5 WWTR1 Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000361 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q7L9L4 MOB1B Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000372 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H8S9 MOB1A Hsap 65bc474400000269 Hippo signaling core components, WWC2 variant (Human). NCBITaxon:9606 gomodel:65bc474400000269/65bc474400000383 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13188 STK3 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000404 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13043 STK4 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000415 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000426 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9ULE0 WWC3 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000439 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95835 LATS1 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000452 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000463 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937 YAP1 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000478 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q9GZV5 WWTR1 Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000495 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q7L9L4 MOB1B Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000506 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H8S9 MOB1A Hsap 65bc474400000403 Hippo signaling core components, WWC3 variant (Human). NCBITaxon:9606 gomodel:65bc474400000403/65bc474400000517 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13188 STK3 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000538 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q13043 STK4 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000549 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000560 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q8IX03 WWC1 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000573 GO:0035591 signaling adaptor activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95835 LATS1 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000586 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000597 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937 YAP1 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000612 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q9GZV5 WWTR1 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000629 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q7L9L4 MOB1B Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000640 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H8S9 MOB1A Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000651 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:O95819 MAP4K4 Hsap 65bc474400000537 Regulation of Hippo signaling by MAP4K4 (Human). NCBITaxon:9606 gomodel:65bc474400000537/65bc474400000939 GO:0008349 MAP kinase kinase kinase kinase activity GO:0035332 positive regulation of hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H7Z6 KAT8 Hsap 65bc474400000788 Nuclear import of KAT8 (Human). NCBITaxon:9606 gomodel:65bc474400000788/65bc474400000789 GO:0046972 histone H4K16 acetyltransferase activity GO:0045893 positive regulation of DNA-templated transcription GO:0005634 nucleus false UniProtKB:P52292 KPNA2 Hsap 65bc474400000788 Nuclear import of KAT8 (Human). NCBITaxon:9606 gomodel:65bc474400000788/65bc474400000796 GO:0140142 nucleocytoplasmic carrier activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q14974 KPNB1 Hsap 65bc474400000788 Nuclear import of KAT8 (Human). NCBITaxon:9606 gomodel:65bc474400000788/65bc474400000805 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus false UniProtKB:Q9UHD2 TBK1 Hsap 65bc474400000824 Acetylation of IRF3 by KAT8 inhibits type I interferon production (Human) NCBITaxon:9606 gomodel:65bc474400000824/65bc474400000836 GO:0004674 protein serine/threonine kinase activity GO:0140374 antiviral innate immune response GO:0005829 cytosol false UniProtKB:Q14653 IRF3 Hsap 65bc474400000824 Acetylation of IRF3 by KAT8 inhibits type I interferon production (Human) NCBITaxon:9606 gomodel:65bc474400000824/65bc474400000848 GO:0003700 DNA-binding transcription factor activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q9H7Z6 KAT8 Hsap 65bc474400000824 Acetylation of IRF3 by KAT8 inhibits type I interferon production (Human) NCBITaxon:9606 gomodel:65bc474400000824/65bc474400000858 GO:0061733 protein-lysine-acetyltransferase activity GO:0032480 negative regulation of type I interferon production GO:0005634 nucleus false UniProtKB:O95835 LATS1 Hsap 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001004 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9NRM7 LATS2 Hsap 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001015 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:P46937 YAP1 Hsap 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001030 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q9GZV5 WWTR1 Hsap 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001047 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:O95819 MAP4K4 Hsap 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001089 GO:0008349 MAP kinase kinase kinase kinase activity GO:0035332 positive regulation of hippo signaling GO:0005737 cytoplasm false GO:0090443 FAR/SIN/STRIPAK complex 65bc474400000955 Negative regulation of Hippo signaling by STRIPAK complex via STRN4:MAP4K4(Human). NCBITaxon:9606 gomodel:65bc474400000955/65bc474400001102 GO:0030674 protein-macromolecule adaptor activity GO:0035331 negative regulation of hippo signaling GO:0005737 cytoplasm false UniProtKB:O95863 SNAI1 Hsap 65bc474400001510 KDM1A acetylation by KAT8 inhibits epithelial to mesenchymal transition (Human). NCBITaxon:9606 gomodel:65bc474400001510/65bc474400001511 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001837 epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:O60341 KDM1A Hsap 65bc474400001510 KDM1A acetylation by KAT8 inhibits epithelial to mesenchymal transition (Human). NCBITaxon:9606 gomodel:65bc474400001510/65bc474400001521 GO:0032453 histone H3K4 demethylase activity GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0000785 chromatin false UniProtKB:Q9H7Z6 KAT8 Hsap 65bc474400001510 KDM1A acetylation by KAT8 inhibits epithelial to mesenchymal transition (Human). NCBITaxon:9606 gomodel:65bc474400001510/65bc474400001529 GO:0061733 protein-lysine-acetyltransferase activity GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:Q99988 GDF15 Hsap 65bc474400001544 Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). NCBITaxon:9606 gomodel:65bc474400001544/65bc474400001545 GO:0005179 hormone activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005576 extracellular region false UniProtKB:Q6UXV0 GFRAL Hsap 65bc474400001544 Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). NCBITaxon:9606 gomodel:65bc474400001544/65bc474400001555 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65bc474400001544 Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). NCBITaxon:9606 gomodel:65bc474400001544/65bc474400001564 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005886 plasma membrane false UniProtKB:P18848 ATF4 Hsap 65bc474400001544 Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). NCBITaxon:9606 gomodel:65bc474400001544/65bc474400001575 GO:0003700 DNA-binding transcription factor activity GO:0140467 integrated stress response signaling GO:0005634 nucleus false UniProtKB:P35638 DDIT3 Hsap 65bc474400001544 Activation of the GDF15-GFRAL aversive signaling pathway in response to stress (Human). NCBITaxon:9606 gomodel:65bc474400001544/65bc474400001586 GO:0003700 DNA-binding transcription factor activity GO:0140467 integrated stress response signaling GO:0005634 nucleus false UniProtKB:Q99988 GDF15 Hsap 65c57c3400000000 Inhibition of the GDF15-GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 (Human). NCBITaxon:9606 gomodel:65c57c3400000000/65c57c3400000001 GO:0005179 hormone activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005576 extracellular region false UniProtKB:Q6UXV0 GFRAL Hsap 65c57c3400000000 Inhibition of the GDF15-GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 (Human). NCBITaxon:9606 gomodel:65c57c3400000000/65c57c3400000011 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65c57c3400000000 Inhibition of the GDF15-GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 (Human). NCBITaxon:9606 gomodel:65c57c3400000000/65c57c3400000020 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0160144 GDF15-GFRAL signaling pathway GO:0005886 plasma membrane false UniProtKB:P50281 MMP14 Hsap 65c57c3400000000 Inhibition of the GDF15-GFRAL aversive signaling pathway following cleavage of GFRAL by MMP14 (Human). NCBITaxon:9606 gomodel:65c57c3400000000/65c57c3400000055 GO:0004222 metalloendopeptidase activity GO:0030163 protein catabolic process GO:0005886 plasma membrane false UniProtKB:Q96FZ2 HMCES Hsap 65c57c3400000100 Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). NCBITaxon:9606 gomodel:65c57c3400000100/65c57c3400000122 GO:0140431 DNA-(abasic site) binding GO:0106300 protein-DNA covalent cross-linking repair GO:0005657 replication fork false UniProtKB:Q96FZ2 HMCES Hsap 65c57c3400000100 Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). NCBITaxon:9606 gomodel:65c57c3400000100/65c57c3400000137 GO:0160129 protein-DNA covalent cross-linking activity GO:0106300 protein-DNA covalent cross-linking repair GO:0005657 replication fork false UniProtKB:Q9BX63 BRIP1 Hsap 65c57c3400000100 Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). NCBITaxon:9606 gomodel:65c57c3400000100/65c57c3400000153 GO:0043139 5'-3' DNA helicase activity GO:0106300 protein-DNA covalent cross-linking repair GO:0005657 replication fork false UniProtKB:Q9H040 SPRTN Hsap 65c57c3400000100 Resolution of protein-DNA cross-links by HMCES, BRIP1/FANCJ and SPRTN (Human). NCBITaxon:9606 gomodel:65c57c3400000100/65c57c3400000162 GO:0004222 metalloendopeptidase activity GO:0106300 protein-DNA covalent cross-linking repair GO:0000785 chromatin false UniProtKB:Q9H7Z6 KAT8 Hsap 65c57c3400000173 The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human). NCBITaxon:9606 gomodel:65c57c3400000173/65c57c3400000174 GO:0046972 histone H4K16 acetyltransferase activity GO:0045893 positive regulation of DNA-templated transcription GO:0005634 nucleus false UniProtKB:Q8N5Y2 MSL3 Hsap 65c57c3400000173 The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human). NCBITaxon:9606 gomodel:65c57c3400000173/65c57c3400000183 GO:0140566 histone reader activity GO:0045893 positive regulation of DNA-templated transcription GO:0005634 nucleus false UniProtKB:Q68DK7 MSL1 Hsap 65c57c3400000173 The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human). NCBITaxon:9606 gomodel:65c57c3400000173/65c57c3400000190 GO:0030674 protein-macromolecule adaptor activity GO:0045893 positive regulation of DNA-templated transcription GO:0005634 nucleus false UniProtKB:Q9HCI7 MSL2 Hsap 65c57c3400000173 The MSL complex, composed of MSL1, MSL2, MSL3 and KAT8, mediates acetylation of histone H4 at Lys-16 (H4K16ac) (Human). NCBITaxon:9606 gomodel:65c57c3400000173/65c57c3400000203 GO:0140463 chromatin-protein adaptor activity GO:0071168 protein localization to chromatin GO:0005634 nucleus false UniProtKB:Q9NP73 ALG13 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400000688 GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q96F25 ALG14 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400000695 GO:0043495 protein-membrane adaptor activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q9BT22 ALG1 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400000703 GO:0004578 chitobiosyldiphosphodolichol beta-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q9H553 ALG2 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400000710 GO:0000033 alpha-1,3-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q9H553 ALG2 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400001007 GO:0102704 GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q9Y673 ALG5 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400001179 GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true dolichol_phosphate_sugar_donor_supply UniProtKB:Q9Y672 ALG6 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400001187 GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q9BVK2 ALG8 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400001190 GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q5I7T1 ALG10B Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65c57c3400001194 GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane false UniProtKB:Q2TAA5 ALG11 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000318 GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0005789 endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q92685 ALG3 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000326 GO:0052925 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q9H6U8 ALG9 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000334 GO:0052926 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q9BV10 ALG12 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000341 GO:0052917 dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q9H6U8 ALG9 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000349 GO:0052918 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane true n_glycan_llo_assembly_lumenal UniProtKB:Q9H3H5 DPAGT1 Hsap 65c57c3400000687 Dolichol-linked oligosaccharides biosynthetic pathway (Human) NCBITaxon:9606 gomodel:65c57c3400000687/65d7e4ac00000377 GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0005789 endoplasmic reticulum membrane true n_glycan_llo_assembly_cytoplasmic UniProtKB:Q9BZJ4 SLC25A39 Hsap 65c57c3400001018 Regulation of SLC25A39 by AFG3L2 and iron-sulfur-binding (Human). NCBITaxon:9606 gomodel:65c57c3400001018/65c57c3400001019 GO:0034634 glutathione transmembrane transporter activity GO:0160007 glutathione import into mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BZJ4 SLC25A39 Hsap 65c57c3400001018 Regulation of SLC25A39 by AFG3L2 and iron-sulfur-binding (Human). NCBITaxon:9606 gomodel:65c57c3400001018/65c57c3400001026 GO:0051537 2 iron, 2 sulfur cluster binding GO:0071281 cellular response to iron ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9Y4W6 AFG3L2 Hsap 65c57c3400001018 Regulation of SLC25A39 by AFG3L2 and iron-sulfur-binding (Human). NCBITaxon:9606 gomodel:65c57c3400001018/65c57c3400001035 GO:0004222 metalloendopeptidase activity GO:0072753 cellular response to glutathione GO:0005743 mitochondrial inner membrane false UniProtKB:Q9Y4W6 AFG3L2 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65c57c3400001116 GO:0004222 metalloendopeptidase activity GO:0110097 regulation of calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9UQ90 SPG7 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65c57c3400001131 GO:0004222 metalloendopeptidase activity GO:0110097 regulation of calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9UQ90 SPG7 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65c57c3400001140 GO:0004222 metalloendopeptidase activity GO:0110097 regulation of calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9H4I9 SMDT1 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65c57c3400001149 GO:0030674 protein-macromolecule adaptor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65c57c3400001159 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65d7e4ac00001329 GO:0061891 calcium ion sensor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8IYU8 MICU2 Hsap 65c57c3400001115 Inhibition of SMDT1/EMRE and MCU following cleavage by the m-AAA protease complex (composed of AFG3L2 and SPG7) (Human). NCBITaxon:9606 gomodel:65c57c3400001115/65d7e4ac00001336 GO:0061891 calcium ion sensor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q13188 STK3 Hsap 65c57c3400001478 Negative regulation of Hippo signaling by SLMAP-STRIPAK complex (Human). NCBITaxon:9606 gomodel:65c57c3400001478/65c57c3400001479 GO:0004674 protein serine/threonine kinase activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q9H4B6 SAV1 Hsap 65c57c3400001478 Negative regulation of Hippo signaling by SLMAP-STRIPAK complex (Human). NCBITaxon:9606 gomodel:65c57c3400001478/65c57c3400001501 GO:0043539 protein serine/threonine kinase activator activity GO:0035329 hippo signaling GO:0005737 cytoplasm false UniProtKB:Q14BN4 SLMAP Hsap 65c57c3400001478 Negative regulation of Hippo signaling by SLMAP-STRIPAK complex (Human). NCBITaxon:9606 gomodel:65c57c3400001478/65c57c3400001625 GO:0030674 protein-macromolecule adaptor activity GO:0035331 negative regulation of hippo signaling GO:0005737 cytoplasm false GO:0090443 FAR/SIN/STRIPAK complex 65c57c3400001478 Negative regulation of Hippo signaling by SLMAP-STRIPAK complex (Human). NCBITaxon:9606 gomodel:65c57c3400001478/65c57c3400001633 GO:0004722 protein serine/threonine phosphatase activity GO:0035331 negative regulation of hippo signaling GO:0005737 cytoplasm false UniProtKB:Q5T4W7 ARTN Hsap 65c57c3400001909 The ARTN-GFRA3 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001909/65c57c3400001910 GO:0008083 growth factor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60609 GFRA3 Hsap 65c57c3400001909 The ARTN-GFRA3 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001909/65c57c3400001920 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65c57c3400001909 The ARTN-GFRA3 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001909/65c57c3400001929 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99748 NRTN Hsap 65c57c3400001964 The NRTN-GFRA2 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001964/65c57c3400001965 GO:0008083 growth factor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O00451 GFRA2 Hsap 65c57c3400001964 The NRTN-GFRA2 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001964/65c57c3400001974 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65c57c3400001964 The NRTN-GFRA2 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001964/65c57c3400001983 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P39905 GDNF Hsap 65c57c3400001994 The GDNF-GFRA1 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001994/65c57c3400001995 GO:0008083 growth factor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P56159 GFRA1 Hsap 65c57c3400001994 The GDNF-GFRA1 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001994/65c57c3400002004 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65c57c3400001994 The GDNF-GFRA1 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400001994/65c57c3400002013 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O60542 PSPN Hsap 65c57c3400002024 The PSPN-GFRA4 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400002024/65c57c3400002025 GO:0008083 growth factor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q9GZZ7 GFRA4 Hsap 65c57c3400002024 The PSPN-GFRA4 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400002024/65c57c3400002034 GO:0016167 glial cell-derived neurotrophic factor receptor activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07949 RET Hsap 65c57c3400002024 The PSPN-GFRA4 signaling pathway (Human). NCBITaxon:9606 gomodel:65c57c3400002024/65c57c3400002043 GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P08865 RPSA Hsap 65c57c3400002054 Role of RPSA in antiviral proinflammatory cytokine production (Human) NCBITaxon:9606 gomodel:65c57c3400002054/65c57c3400002055 GO:0003677 DNA binding GO:0140374 antiviral innate immune response GO:0005634 nucleus false UniProtKB:O60264 SMARCA5 Hsap 65c57c3400002054 Role of RPSA in antiviral proinflammatory cytokine production (Human) NCBITaxon:9606 gomodel:65c57c3400002054/65c57c3400002062 GO:0140658 ATP-dependent chromatin remodeler activity GO:0006338 chromatin remodeling GO:0005634 nucleus false UniProtKB:Q04206 RELA Hsap 65c57c3400002054 Role of RPSA in antiviral proinflammatory cytokine production (Human) NCBITaxon:9606 gomodel:65c57c3400002054/65c57c3400002070 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0140374 antiviral innate immune response GO:0000785 chromatin false UniProtKB:Q8WXH4 ASB11 Hsap 65c57c3400002539 The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human). NCBITaxon:9606 gomodel:65c57c3400002539/66187e4700000611 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:Q9UBF6 RNF7 Hsap 65c57c3400002539 The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human). NCBITaxon:9606 gomodel:65c57c3400002539/66187e4700000620 GO:0061630 ubiquitin protein ligase activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:Q96HU8 DIRAS2 Hsap 65c57c3400002539 The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human). NCBITaxon:9606 gomodel:65c57c3400002539/66187e4700000629 GO:0003924 GTPase activity GO:0007165 signal transduction GO:0005886 plasma membrane false UniProtKB:Q93034 CUL5 Hsap 65c57c3400002539 The CRL5(ASB11) complex mediates ubiquitination and degradation of DIRAS2 (Human). NCBITaxon:9606 gomodel:65c57c3400002539/66187e4700000638 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:P09601 HMOX1 Hsap 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/65c57c3400002595 GO:0004392 heme oxygenase (decyclizing) activity GO:0042167 heme catabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:P53004 BLVRA Hsap 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/65c57c3400002613 GO:0004074 biliverdin reductase [NAD(P)H] activity GO:0042167 heme catabolic process GO:0005829 cytosol false UniProtKB:Q92887 ABCC2 Hsap 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/65c57c3400002631 GO:0015127 bilirubin transmembrane transporter activity GO:0015723 bilirubin transport GO:0016324 apical plasma membrane false UniProtKB:P22309 UGT1A1 Hsap 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/65c57c3400002641 GO:0015020 glucuronosyltransferase activity GO:0006789 bilirubin conjugation false UniProtKB:E7GT89 bilR NCBITaxon:742740 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/684b6c8100004030 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0006787 porphyrin-containing compound catabolic process false CHEBI:36080 protein 65c57c3400002594 Heme catabolic process into urobilinogen (Human) NCBITaxon:9606 gomodel:65c57c3400002594/684b6c8100004041 GO:0003824 catalytic activity GO:0042167 heme catabolic process false UniProtKB:P19397 CD53 Hsap 65c57c3400002666 Role of CD53 in T-cell receptor signaling pathway (Human) NCBITaxon:9606 gomodel:65c57c3400002666/65c57c3400002667 GO:0043495 protein-membrane adaptor activity GO:0043113 receptor clustering GO:0005886 plasma membrane false UniProtKB:P08575 PTPRC Hsap 65c57c3400002666 Role of CD53 in T-cell receptor signaling pathway (Human) NCBITaxon:9606 gomodel:65c57c3400002666/65c57c3400002679 GO:0004725 protein tyrosine phosphatase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 65c57c3400002666 Role of CD53 in T-cell receptor signaling pathway (Human) NCBITaxon:9606 gomodel:65c57c3400002666/65c57c3400002689 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 65c57c3400002666 Role of CD53 in T-cell receptor signaling pathway (Human) NCBITaxon:9606 gomodel:65c57c3400002666/65c57c3400002704 GO:0004888 transmembrane signaling receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9H257 CARD9 Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000023 GO:0035591 signaling adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9BXN2 CLEC7A Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000032 GO:0038187 pattern recognition receptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005886 plasma membrane false UniProtKB:O95999 BCL10 Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000040 GO:0030674 protein-macromolecule adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9UDY8 MALT1 Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000047 GO:0004175 endopeptidase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9Y4E8 USP15 Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000062 GO:0004843 cysteine-type deubiquitinase activity GO:0016579 protein deubiquitination GO:0005737 cytoplasm false UniProtKB:Q9BVG3 TRIM62 Hsap 65d7e4ac00000022 CARD9 regulation by TRIM62/USP15 (Human) NCBITaxon:9606 gomodel:65d7e4ac00000022/65d7e4ac00000070 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9NRW4 DUSP22 Hsap 65d7e4ac00000082 DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human) NCBITaxon:9606 gomodel:65d7e4ac00000082/65d7e4ac00000083 GO:0008138 protein tyrosine/serine/threonine phosphatase activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9Y297 BTRC Hsap 65d7e4ac00000082 DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human) NCBITaxon:9606 gomodel:65d7e4ac00000082/65d7e4ac00000092 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q8IWV8 UBR2 Hsap 65d7e4ac00000082 DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human) NCBITaxon:9606 gomodel:65d7e4ac00000082/65d7e4ac00000098 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P06239 LCK Hsap 65d7e4ac00000082 DUSP22 inhibition of TCR signaling via UBR2 inhibition (Human) NCBITaxon:9606 gomodel:65d7e4ac00000082/65d7e4ac00000106 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O00206 TLR4 Hsap 65d7e4ac00001084 oxLDL-CD36 interaction leading to TLR4 signaling and subsequent sterile inflammation in macrophages (Human) NCBITaxon:9606 gomodel:65d7e4ac00001084/65d7e4ac00001093 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P16671 CD36 Hsap 65d7e4ac00001084 oxLDL-CD36 interaction leading to TLR4 signaling and subsequent sterile inflammation in macrophages (Human) NCBITaxon:9606 gomodel:65d7e4ac00001084/65d7e4ac00001225 GO:0150025 oxidised low-density lipoprotein particle receptor activity GO:0034145 positive regulation of toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P07948 LYN Hsap 65d7e4ac00001084 oxLDL-CD36 interaction leading to TLR4 signaling and subsequent sterile inflammation in macrophages (Human) NCBITaxon:9606 gomodel:65d7e4ac00001084/65d7e4ac00001234 GO:0004713 protein tyrosine kinase activity GO:0034145 positive regulation of toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false UniProtKB:P16671 CD36 Hsap 65d7e4ac00001282 Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human) NCBITaxon:9606 gomodel:65d7e4ac00001282/65d7e4ac00001283 GO:0070053 thrombospondin receptor activity GO:0016525 negative regulation of angiogenesis GO:0005886 plasma membrane false UniProtKB:P07996 THBS1 Hsap 65d7e4ac00001282 Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human) NCBITaxon:9606 gomodel:65d7e4ac00001282/65d7e4ac00001285 GO:0005201 extracellular matrix structural constituent GO:0016525 negative regulation of angiogenesis GO:0031012 extracellular matrix false UniProtKB:P35968 KDR Hsap 65d7e4ac00001282 Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human) NCBITaxon:9606 gomodel:65d7e4ac00001282/65d7e4ac00001298 GO:0005021 vascular endothelial growth factor receptor activity GO:0045766 positive regulation of angiogenesis GO:0005886 plasma membrane false UniProtKB:P29350 PTPN6 Hsap 65d7e4ac00001282 Thrombospondin-1/CD36 inhibition of angiogenesis in endothelial cells (Human) NCBITaxon:9606 gomodel:65d7e4ac00001282/65d7e4ac00001303 GO:0004725 protein tyrosine phosphatase activity GO:0016525 negative regulation of angiogenesis GO:0005886 plasma membrane false UniProtKB:Q9H4I9 SMDT1 Hsap 65d7e4ac00001363 Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human). NCBITaxon:9606 gomodel:65d7e4ac00001363/65d7e4ac00001394 GO:0030674 protein-macromolecule adaptor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00001363 Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human). NCBITaxon:9606 gomodel:65d7e4ac00001363/65d7e4ac00001404 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65d7e4ac00001363 Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human). NCBITaxon:9606 gomodel:65d7e4ac00001363/65d7e4ac00001420 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8IYU8 MICU2 Hsap 65d7e4ac00001363 Mitochondrial calcium uptake by the uniplex complex composed of SMDT1/EMRE, MICU1, MICU2 and MCU (Human). NCBITaxon:9606 gomodel:65d7e4ac00001363/65d7e4ac00001427 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65d7e4ac00001584 MICU1 inhibits mitochondrial calcium uptake by occluding MCU in absence of calcium (Human). NCBITaxon:9606 gomodel:65d7e4ac00001584/65d7e4ac00001645 GO:0019855 calcium channel inhibitor activity GO:0072732 cellular response to calcium ion starvation GO:0005743 mitochondrial inner membrane false UniProtKB:Q9H4I9 SMDT1 Hsap 65d7e4ac00001584 MICU1 inhibits mitochondrial calcium uptake by occluding MCU in absence of calcium (Human). NCBITaxon:9606 gomodel:65d7e4ac00001584/65d7e4ac00001658 GO:0030674 protein-macromolecule adaptor activity GO:0072732 cellular response to calcium ion starvation GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00001584 MICU1 inhibits mitochondrial calcium uptake by occluding MCU in absence of calcium (Human). NCBITaxon:9606 gomodel:65d7e4ac00001584/65d7e4ac00001671 GO:0005262 calcium channel activity GO:0072732 cellular response to calcium ion starvation GO:0005743 mitochondrial inner membrane false UniProtKB:P13501 CCL5 Hsap 65d7e4ac00001732 Activation of GPR75 by CCL5 in neurons (Human) NCBITaxon:9606 gomodel:65d7e4ac00001732/65d7e4ac00001733 GO:0008009 chemokine activity GO:0045745 positive regulation of G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O95800 GPR75 Hsap 65d7e4ac00001732 Activation of GPR75 by CCL5 in neurons (Human) NCBITaxon:9606 gomodel:65d7e4ac00001732/65d7e4ac00001740 GO:0004930 G protein-coupled receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P27361 MAPK3 Hsap 65d7e4ac00001732 Activation of GPR75 by CCL5 in neurons (Human) NCBITaxon:9606 gomodel:65d7e4ac00001732/65d7e4ac00001752 GO:0004674 protein serine/threonine kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:P28482 MAPK1 Hsap 65d7e4ac00001732 Activation of GPR75 by CCL5 in neurons (Human) NCBITaxon:9606 gomodel:65d7e4ac00001732/65d7e4ac00001760 GO:0004674 protein serine/threonine kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:Q9NVJ2 ARL8B Hsap 65d7e4ac00001800 RUFY1 mediates early endosome to Golgi transport. (Human) NCBITaxon:9606 gomodel:65d7e4ac00001800/65d7e4ac00001801 GO:0003924 GTPase activity GO:1902946 protein localization to early endosome GO:0031901 early endosome membrane false UniProtKB:Q96T51 RUFY1 Hsap 65d7e4ac00001800 RUFY1 mediates early endosome to Golgi transport. (Human) NCBITaxon:9606 gomodel:65d7e4ac00001800/65d7e4ac00001812 GO:0030674 protein-macromolecule adaptor activity GO:0034058 endosomal vesicle fusion GO:0031901 early endosome membrane false UniProtKB:P61018 RAB4B Hsap 65d7e4ac00001800 RUFY1 mediates early endosome to Golgi transport. (Human) NCBITaxon:9606 gomodel:65d7e4ac00001800/65d7e4ac00001826 GO:0003924 GTPase activity GO:0034058 endosomal vesicle fusion GO:0031901 early endosome membrane false UniProtKB:P61106 RAB14 Hsap 65d7e4ac00001800 RUFY1 mediates early endosome to Golgi transport. (Human) NCBITaxon:9606 gomodel:65d7e4ac00001800/65d7e4ac00001834 GO:0003924 GTPase activity GO:0034058 endosomal vesicle fusion GO:0031901 early endosome membrane false UniProtKB:P13232 IL7 Hsap 65d7e4ac00001856 IL7 signaling role in iNKT cells homeostasis (Human) NCBITaxon:9606 gomodel:65d7e4ac00001856/65d7e4ac00001858 GO:0005125 cytokine activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P31785 IL2RG Hsap 65d7e4ac00001856 IL7 signaling role in iNKT cells homeostasis (Human) NCBITaxon:9606 gomodel:65d7e4ac00001856/65d7e4ac00001862 GO:0015026 coreceptor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P16871 IL7R Hsap 65d7e4ac00001856 IL7 signaling role in iNKT cells homeostasis (Human) NCBITaxon:9606 gomodel:65d7e4ac00001856/65d7e4ac00001866 GO:0004917 interleukin-7 receptor activity GO:0038111 interleukin-7-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P38646 HSPA9 Hsap 65d7e4ac00002121 Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) NCBITaxon:9606 gomodel:65d7e4ac00002121/65d7e4ac00002122 GO:0030674 protein-macromolecule adaptor activity GO:0036444 calcium import into the mitochondrion GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site false UniProtKB:Q14643 ITPR1 Hsap 65d7e4ac00002121 Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) NCBITaxon:9606 gomodel:65d7e4ac00002121/65d7e4ac00002129 GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site false UniProtKB:P21796 VDAC1 Hsap 65d7e4ac00002121 Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) NCBITaxon:9606 gomodel:65d7e4ac00002121/65d7e4ac00002156 GO:0005245 voltage-gated calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00002121 Apoptosis-induced by calcium import into mitochondria at ER-mitochondria contact sites mediated by the ITPR1:HSPA9:VDAC1 complex (Human) NCBITaxon:9606 gomodel:65d7e4ac00002121/65d7e4ac00002883 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q29983 MICA Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000353 GO:0048018 receptor ligand activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P26718 KLRK1 Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000360 GO:0038023 signaling receptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:Q9UBK5 HCST Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000370 GO:0030674 protein-macromolecule adaptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P27986 PIK3R1 Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000381 GO:0035014 phosphatidylinositol 3-kinase regulator activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P62993 GRB2 Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000393 GO:0005091 guanyl-nucleotide exchange factor adaptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P15498 VAV1 Hsap 65d7e4ac00002427 MICA-NKG2D mediated NK cell cytotoxicity (Human) NCBITaxon:9606 gomodel:65d7e4ac00002427/65f3ae5c00000400 GO:0005085 guanyl-nucleotide exchange factor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:Q9H4I9 SMDT1 Hsap 65d7e4ac00002435 MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human). NCBITaxon:9606 gomodel:65d7e4ac00002435/65d7e4ac00002436 GO:0030674 protein-macromolecule adaptor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00002435 MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human). NCBITaxon:9606 gomodel:65d7e4ac00002435/65d7e4ac00002446 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65d7e4ac00002435 MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human). NCBITaxon:9606 gomodel:65d7e4ac00002435/65d7e4ac00002458 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q86XE3 MICU3 Hsap 65d7e4ac00002435 MICU3 promotes mitochondrial calcium uptake by MCU in the central nervous system (Human). NCBITaxon:9606 gomodel:65d7e4ac00002435/65d7e4ac00002465 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9H4I9 SMDT1 Hsap 65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). NCBITaxon:9606 gomodel:65d7e4ac00002808/65d7e4ac00002809 GO:0030674 protein-macromolecule adaptor activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). NCBITaxon:9606 gomodel:65d7e4ac00002808/65d7e4ac00002819 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). NCBITaxon:9606 gomodel:65d7e4ac00002808/65d7e4ac00002831 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8IYU8 MICU2 Hsap 65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). NCBITaxon:9606 gomodel:65d7e4ac00002808/65d7e4ac00002838 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9NWR8 MCUB Hsap 65d7e4ac00002808 MCUB inhibits mitochondrial calcium uptake by the uniplex complex (composed of SMDT1/EMRE, MICU1, MICU2 and MCU) to prevent calcium overload (Human). NCBITaxon:9606 gomodel:65d7e4ac00002808/65d7e4ac00002873 GO:0019855 calcium channel inhibitor activity GO:0110099 negative regulation of calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8NE86 MCU Hsap 65d7e4ac00002910 AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human). NCBITaxon:9606 gomodel:65d7e4ac00002910/65d7e4ac00002921 GO:0005262 calcium channel activity GO:0036444 calcium import into the mitochondrion GO:0005743 mitochondrial inner membrane false UniProtKB:Q9BPX6 MICU1 Hsap 65d7e4ac00002910 AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human). NCBITaxon:9606 gomodel:65d7e4ac00002910/65d7e4ac00002933 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:Q8IYU8 MICU2 Hsap 65d7e4ac00002910 AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human). NCBITaxon:9606 gomodel:65d7e4ac00002910/65d7e4ac00002940 GO:0061891 calcium ion sensor activity GO:0071277 cellular response to calcium ion GO:0005743 mitochondrial inner membrane false UniProtKB:P31749 AKT1 Hsap 65d7e4ac00002910 AKT1 affect mitochondrial calcium uptake in response to rapamycin by mediating phosphorylation of MICU1 (Human). NCBITaxon:9606 gomodel:65d7e4ac00002910/65d7e4ac00002981 GO:0004674 protein serine/threonine kinase activity GO:1903318 negative regulation of protein maturation GO:0005758 mitochondrial intermembrane space false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00000111 Ufmylation pathway (Human). NCBITaxon:9606 gomodel:65f3ae5c00000111/65f3ae5c00000112 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation false UniProtKB:Q9Y3C8 UFC1 Hsap 65f3ae5c00000111 Ufmylation pathway (Human). NCBITaxon:9606 gomodel:65f3ae5c00000111/65f3ae5c00000121 GO:0061657 UFM1 conjugating enzyme activity GO:0071569 protein ufmylation false UniProtKB:Q9GZZ9 UBA5 Hsap 65f3ae5c00000111 Ufmylation pathway (Human). NCBITaxon:9606 gomodel:65f3ae5c00000111/65f3ae5c00000131 GO:0071566 UFM1 activating enzyme activity GO:0071569 protein ufmylation false UniProtKB:Q6NVU6 UFSP1 Hsap 65f3ae5c00000111 Ufmylation pathway (Human). NCBITaxon:9606 gomodel:65f3ae5c00000111/65f3ae5c00000152 GO:0008234 cysteine-type peptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000171 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q96JB5 CDK5RAP3 Hsap 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000184 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:P61221 ABCE1 Hsap 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000206 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false GO:0022625 cytosolic large ribosomal subunit 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000215 GO:0003735 structural constituent of ribosome GO:0032790 ribosome disassembly GO:0005789 endoplasmic reticulum membrane false GO:0022625 cytosolic large ribosomal subunit 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000223 GO:0003735 structural constituent of ribosome GO:0032790 ribosome disassembly GO:0005829 cytosol false UniProtKB:Q96HY6 DDRGK1 Hsap 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000231 GO:0141185 UFM1-modified protein reader activity GO:0032790 ribosome disassembly GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9NUQ7 UFSP2 Hsap 65f3ae5c00000170 Ufmylation of RPL26 following translation termination promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000170/65f3ae5c00000249 GO:0071567 deUFMylase activity GO:0032790 ribosome disassembly false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000258 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q96JB5 CDK5RAP3 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000271 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:P61221 ABCE1 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000291 GO:0017111 ribonucleoside triphosphate phosphatase activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false GO:0022625 cytosolic large ribosomal subunit 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000300 GO:0003735 structural constituent of ribosome GO:0072344 rescue of stalled cytosolic ribosome GO:0005789 endoplasmic reticulum membrane false GO:0022625 cytosolic large ribosomal subunit 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000308 GO:0003735 structural constituent of ribosome GO:0072344 rescue of stalled cytosolic ribosome GO:0005829 cytosol false UniProtKB:Q96HY6 DDRGK1 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000316 GO:0141185 UFM1-modified protein reader activity GO:0072344 rescue of stalled cytosolic ribosome GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9NUQ7 UFSP2 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000334 GO:0071567 deUFMylase activity GO:0072344 rescue of stalled cytosolic ribosome false UniProtKB:Q8N3C0 ASCC3 Hsap 65f3ae5c00000257 Ufmylation of RPL26 following ribosome stalling promotes 60S ribosomal subunit recycling (Human). NCBITaxon:9606 gomodel:65f3ae5c00000257/65f3ae5c00000342 GO:0016887 ATP hydrolysis activity GO:0032790 ribosome disassembly GO:0022626 cytosolic ribosome false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). NCBITaxon:9606 gomodel:65f3ae5c00000585/65f3ae5c00000586 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q96JB5 CDK5RAP3 Hsap 65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). NCBITaxon:9606 gomodel:65f3ae5c00000585/65f3ae5c00000599 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0071569 protein ufmylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q96HY6 DDRGK1 Hsap 65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). NCBITaxon:9606 gomodel:65f3ae5c00000585/65f3ae5c00000644 GO:0141185 UFM1-modified protein reader activity GO:0140501 positive regulation of reticulophagy GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9NUQ7 UFSP2 Hsap 65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). NCBITaxon:9606 gomodel:65f3ae5c00000585/65f3ae5c00000662 GO:0071567 deUFMylase activity GO:0042177 negative regulation of protein catabolic process false UniProtKB:P00387 CYB5R3 Hsap 65f3ae5c00000585 Ufmylation of CYB5R3 promotes reticulophagy and CYB5R3 degradation (Human). NCBITaxon:9606 gomodel:65f3ae5c00000585/65f3ae5c00000674 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H GO:0008015 blood circulation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q13131 PRKAA1 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001023 GO:0004679 AMP-activated protein kinase activity GO:0002842 positive regulation of T cell mediated immune response to tumor cell false UniProtKB:P61981 YWHAG Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001032 GO:0140311 protein sequestering activity GO:0002842 positive regulation of T cell mediated immune response to tumor cell false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001042 GO:0061666 UFM1 ligase activity GO:0050821 protein stabilization false UniProtKB:Q15116 PDCD1 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001053 GO:0004888 transmembrane signaling receptor activity GO:0002841 negative regulation of T cell mediated immune response to tumor cell GO:0005886 plasma membrane false UniProtKB:Q9NZQ7 CD274 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001060 GO:0048018 receptor ligand activity GO:0002841 negative regulation of T cell mediated immune response to tumor cell GO:0005886 plasma membrane false UniProtKB:Q53GT1 KLHL22 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001075 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q6PIJ6 FBXO38 Hsap 65f3ae5c00001022 UFL1 negatively regulates T-cell activation by mediating ufmylation of PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001022/65f3ae5c00001089 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P04637 TP53 Hsap 65f3ae5c00001357 Ufmylation of TP53/p53 counteracts ubiquitination and degradation of TP53/p53 by MDM2 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001357/65f3ae5c00001358 GO:0003700 DNA-binding transcription factor activity GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0000785 chromatin false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00001357 Ufmylation of TP53/p53 counteracts ubiquitination and degradation of TP53/p53 by MDM2 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001357/65f3ae5c00001365 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation false UniProtKB:Q00987 MDM2 Hsap 65f3ae5c00001357 Ufmylation of TP53/p53 counteracts ubiquitination and degradation of TP53/p53 by MDM2 (Human). NCBITaxon:9606 gomodel:65f3ae5c00001357/65f3ae5c00001376 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q92478 CLEC2B Hsap 65f3ae5c00001388 LR-NK cell activation by the NKp80-AICL interaction (Human) NCBITaxon:9606 gomodel:65f3ae5c00001388/65f3ae5c00001389 GO:0048018 receptor ligand activity GO:0051132 NK T cell activation GO:0005886 plasma membrane false UniProtKB:Q9NZS2 KLRF1 Hsap 65f3ae5c00001388 LR-NK cell activation by the NKp80-AICL interaction (Human) NCBITaxon:9606 gomodel:65f3ae5c00001388/65f3ae5c00001398 GO:0004888 transmembrane signaling receptor activity GO:0051132 NK T cell activation GO:0005886 plasma membrane false UniProtKB:O00206 TLR4 Hsap 65f3ae5c00001388 LR-NK cell activation by the NKp80-AICL interaction (Human) NCBITaxon:9606 gomodel:65f3ae5c00001388/65f3ae5c00001409 GO:0001875 lipopolysaccharide immune receptor activity GO:0071222 cellular response to lipopolysaccharide GO:0005886 plasma membrane false UniProtKB:O94874 UFL1 Hsap 65f3ae5c00001692 STK38 recognizes ufmylated histone H4 in response to DNA damage, leading to ATM activation (Human). NCBITaxon:9606 gomodel:65f3ae5c00001692/65f3ae5c00001693 GO:0061666 UFM1 ligase activity GO:0071569 protein ufmylation GO:0035861 site of double-strand break false UniProtKB:Q13315 ATM Hsap 65f3ae5c00001692 STK38 recognizes ufmylated histone H4 in response to DNA damage, leading to ATM activation (Human). NCBITaxon:9606 gomodel:65f3ae5c00001692/65f3ae5c00001704 GO:0004674 protein serine/threonine kinase activity GO:0000077 DNA damage checkpoint signaling false UniProtKB:Q15208 STK38 Hsap 65f3ae5c00001692 STK38 recognizes ufmylated histone H4 in response to DNA damage, leading to ATM activation (Human). NCBITaxon:9606 gomodel:65f3ae5c00001692/65f3ae5c00001710 GO:0140035 ubiquitin-like protein reader activity GO:0000077 DNA damage checkpoint signaling GO:0035861 site of double-strand break false UniProtKB:Q96GR4 ZDHHC12 Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/65f3ae5c00002179 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0097116 gephyrin clustering involved in postsynaptic density assembly GO:0000139 Golgi membrane false UniProtKB:Q9NQX3 GPHN Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/65f3ae5c00002188 GO:0030674 protein-macromolecule adaptor activity GO:0097112 gamma-aminobutyric acid receptor clustering GO:0045211 postsynaptic membrane false UniProtKB:P14867 GABRA1 Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/65f3ae5c00002317 GO:0004890 GABA-A receptor activity GO:0051932 synaptic transmission, GABAergic GO:0045211 postsynaptic membrane false UniProtKB:P47870 GABRB2 Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/65f3ae5c00002353 GO:0004890 GABA-A receptor activity GO:0051932 synaptic transmission, GABAergic GO:0045211 postsynaptic membrane false UniProtKB:P18507-1 GABRG2 Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/65f3ae5c00002364 GO:0004890 GABA-A receptor activity GO:0051932 synaptic transmission, GABAergic GO:0045211 postsynaptic membrane false UniProtKB:P28472 GABRB3 Hsap 65f3ae5c00002132 Control of GABAAR clustering to GABAergic synapses by Gephyrin (Human) NCBITaxon:9606 gomodel:65f3ae5c00002132/6606056e00000219 GO:0004890 GABA-A receptor activity GO:0051932 synaptic transmission, GABAergic GO:0045211 postsynaptic membrane false UniProtKB:Q07108 CD69 Hsap 6606056e00000234 CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) NCBITaxon:9606 gomodel:6606056e00000234/6606056e00000235 GO:0004888 transmembrane signaling receptor activity GO:0050728 negative regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:O95644 NFATC1 Hsap 6606056e00000234 CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) NCBITaxon:9606 gomodel:6606056e00000234/6606056e00000250 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0050728 negative regulation of inflammatory response GO:0005634 nucleus false UniProtKB:Q15116 PDCD1 Hsap 6606056e00000234 CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) NCBITaxon:9606 gomodel:6606056e00000234/6606056e00000262 GO:0004888 transmembrane signaling receptor activity GO:0050728 negative regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:Q92570 NR4A3 Hsap 6606056e00000234 CD69-OxydizedLDL pair leading to PD-1 expression in T-cells (Human) NCBITaxon:9606 gomodel:6606056e00000234/6606056e00000270 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0050728 negative regulation of inflammatory response GO:0005634 nucleus false UniProtKB:Q07108 CD69 Hsap 6606056e00000282 LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) NCBITaxon:9606 gomodel:6606056e00000282/6606056e00000283 GO:0004888 transmembrane signaling receptor activity GO:2000329 negative regulation of T-helper 17 cell lineage commitment GO:0005886 plasma membrane false UniProtKB:P52333 JAK3 Hsap 6606056e00000282 LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) NCBITaxon:9606 gomodel:6606056e00000282/6606056e00000290 GO:0004713 protein tyrosine kinase activity GO:2000329 negative regulation of T-helper 17 cell lineage commitment GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P42229 STAT5A Hsap 6606056e00000282 LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) NCBITaxon:9606 gomodel:6606056e00000282/6606056e00000301 GO:0003700 DNA-binding transcription factor activity GO:2000329 negative regulation of T-helper 17 cell lineage commitment GO:0005634 nucleus false UniProtKB:P09382 LGALS1 Hsap 6606056e00000282 LGALS1-CD69 pair involved in negative regulation of T-helper 17 cell lineage (Human) NCBITaxon:9606 gomodel:6606056e00000282/6606056e00000309 GO:0048018 receptor ligand activity GO:2000329 negative regulation of T-helper 17 cell lineage commitment GO:0005886 plasma membrane false UniProtKB:Q5T4S7 UBR4 Hsap 6606056e00000317 UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human). NCBITaxon:9606 gomodel:6606056e00000317/6606056e00000318 GO:0061630 ubiquitin protein ligase activity GO:0070979 protein K11-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O95071 UBR5 Hsap 6606056e00000317 UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human). NCBITaxon:9606 gomodel:6606056e00000317/6606056e00000327 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P55072 VCP Hsap 6606056e00000317 UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human). NCBITaxon:9606 gomodel:6606056e00000317/6606056e00000332 GO:0140036 ubiquitin-modified protein reader activity GO:0140455 cytoplasm protein quality control GO:0005737 cytoplasm false GO:0005839 proteasome core complex 6606056e00000317 UBR4 and UBR5 catalyze branched-linked polyubiquitination of substrates, leading to proteasome-mediated degradation of substrates (Human). NCBITaxon:9606 gomodel:6606056e00000317/6606056e00000347 GO:0004175 endopeptidase activity GO:0010498 proteasomal protein catabolic process GO:0005737 cytoplasm false UniProtKB:P21453 S1PR1 Hsap 6606056e00000363 Inhibition by CD69 of S1PR1-mediated T-cell migration (Human) NCBITaxon:9606 gomodel:6606056e00000363/6606056e00000364 GO:0038036 sphingosine-1-phosphate receptor activity GO:0003376 sphingosine-1-phosphate receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q07108 CD69 Hsap 6606056e00000363 Inhibition by CD69 of S1PR1-mediated T-cell migration (Human) NCBITaxon:9606 gomodel:6606056e00000363/6606056e00000375 GO:0140313 molecular sequestering activity GO:2000405 negative regulation of T cell migration GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 6606056e00000363 Inhibition by CD69 of S1PR1-mediated T-cell migration (Human) NCBITaxon:9606 gomodel:6606056e00000363/6606056e00000425 GO:0003924 GTPase activity GO:0072678 T cell migration GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9Y6Q9 NCOA3 Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000497 GO:0003713 transcription coactivator activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:P10276 RARA Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000505 GO:0004879 nuclear receptor activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:P19793 RXRA Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000525 GO:0004879 nuclear receptor activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q9Y6Q9 NCOA3 Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000537 GO:0003713 transcription coactivator activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000554 GO:0061630 ubiquitin protein ligase activity GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000485 UBR5 ubiquitinates ligand-bound RARA and RXRA when RARA and RXRA are not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000485/6606056e00000563 GO:0061630 ubiquitin protein ligase activity GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system GO:0000785 chromatin false UniProtKB:Q9Y6Q9 NCOA3 Hsap 6606056e00000576 UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000576/6606056e00000582 GO:0003713 transcription coactivator activity GO:0070561 vitamin D receptor signaling pathway GO:0000785 chromatin false UniProtKB:P11473 VDR Hsap 6606056e00000576 UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000576/6606056e00000586 GO:0004879 nuclear receptor activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000576 UBR5 ubiquitinates ligand-bound VDR when VDR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000576/6606056e00000605 GO:0061630 ubiquitin protein ligase activity GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system GO:0000785 chromatin false UniProtKB:Q15788 NCOA1 Hsap 6606056e00000637 UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000637/6606056e00000638 GO:0003713 transcription coactivator activity GO:0050847 progesterone receptor signaling pathway GO:0000785 chromatin false UniProtKB:P06401 PGR Hsap 6606056e00000637 UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000637/6606056e00000642 GO:0004879 nuclear receptor activity GO:0050847 progesterone receptor signaling pathway GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000637 UBR5 ubiquitinates ligand-bound PGR when PGR is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000637/6606056e00000648 GO:0061630 ubiquitin protein ligase activity GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system GO:0000785 chromatin false UniProtKB:Q15788 NCOA1 Hsap 6606056e00000678 UBR5 ubiquitinates ligand-bound ESR1 when ESR1 is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000678/6606056e00000679 GO:0003713 transcription coactivator activity GO:0030520 estrogen receptor signaling pathway GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000678 UBR5 ubiquitinates ligand-bound ESR1 when ESR1 is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000678/6606056e00000689 GO:0061630 ubiquitin protein ligase activity GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system GO:0000785 chromatin false UniProtKB:P03372 ESR1 Hsap 6606056e00000678 UBR5 ubiquitinates ligand-bound ESR1 when ESR1 is not associated with Nuclear receptor coactivators (NCOAs) (Human). NCBITaxon:9606 gomodel:6606056e00000678/6606056e00000694 GO:0004879 nuclear receptor activity GO:0030520 estrogen receptor signaling pathway GO:0000785 chromatin false UniProtKB:O95071 UBR5 Hsap 6606056e00000767 ITCH and UBR5 catalyzed branched-linked polyubiquitination of TXNIP (Human). NCBITaxon:9606 gomodel:6606056e00000767/6606056e00000768 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0141198 protein branched polyubiquitination false UniProtKB:Q96J02 ITCH Hsap 6606056e00000767 ITCH and UBR5 catalyzed branched-linked polyubiquitination of TXNIP (Human). NCBITaxon:9606 gomodel:6606056e00000767/6606056e00000775 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0141198 protein branched polyubiquitination false UniProtKB:Q9H3M7 TXNIP Hsap 6606056e00000767 ITCH and UBR5 catalyzed branched-linked polyubiquitination of TXNIP (Human). NCBITaxon:9606 gomodel:6606056e00000767/6606056e00000784 GO:0004857 enzyme inhibitor activity GO:0006979 response to oxidative stress GO:0005737 cytoplasm false UniProtKB:P02649 APOE Hsap 6606056e00000859 TREM2 activated by APOE. (Human) NCBITaxon:9606 gomodel:6606056e00000859/6606056e00000860 GO:0048018 receptor ligand activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00000859 TREM2 activated by APOE. (Human) NCBITaxon:9606 gomodel:6606056e00000859/6606056e00000867 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00000859 TREM2 activated by APOE. (Human) NCBITaxon:9606 gomodel:6606056e00000859/6606056e00000881 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00000859 TREM2 activated by APOE. (Human) NCBITaxon:9606 gomodel:6606056e00000859/6606056e00000893 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:Q14154 DELE1 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000904 GO:0043539 protein serine/threonine kinase activator activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:Q96E52 OMA1 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000920 GO:0004222 metalloendopeptidase activity GO:0033554 cellular response to stress GO:0005758 mitochondrial intermembrane space false UniProtKB:Q9BQI3 EIF2AK1 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000938 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000953 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000964 GO:0003700 DNA-binding transcription factor activity GO:0140468 HRI-mediated signaling GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000975 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P35638 DDIT3 Hsap 6606056e00000903 Activation of the integrated stress response via activation of EIF2AK1/HRI by DELE1 in response to mitochondrial stress (Human) NCBITaxon:9606 gomodel:6606056e00000903/6606056e00000993 GO:0003700 DNA-binding transcription factor activity GO:0140468 HRI-mediated signaling GO:0005634 nucleus false UniProtKB:Q9P0J7 KCMF1 Hsap 6606056e00001072 Ubiquitination by the SIFI complex composed of UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001072/6606056e00001142 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q5T4S7 UBR4 Hsap 6606056e00001072 Ubiquitination by the SIFI complex composed of UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001072/6606056e00001151 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P49459 UBE2A Hsap 6606056e00001072 Ubiquitination by the SIFI complex composed of UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001072/6606056e00001173 GO:0061631 ubiquitin conjugating enzyme activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q9Y6Q9 NCOA3 Hsap 6606056e00001308 Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). NCBITaxon:9606 gomodel:6606056e00001308/6606056e00001310 GO:0003713 transcription coactivator activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:P10276 RARA Hsap 6606056e00001308 Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). NCBITaxon:9606 gomodel:6606056e00001308/6606056e00001317 GO:0004879 nuclear receptor activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:P19793 RXRA Hsap 6606056e00001308 Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). NCBITaxon:9606 gomodel:6606056e00001308/6606056e00001325 GO:0004879 nuclear receptor activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q9Y6Q9 NCOA3 Hsap 6606056e00001308 Retinoic acid binds and activates RARA and RXRA nuclear receptors (Human). NCBITaxon:9606 gomodel:6606056e00001308/6606056e00001332 GO:0003713 transcription coactivator activity GO:0048384 retinoic acid receptor signaling pathway GO:0000785 chromatin false UniProtKB:P10909 CLU Hsap 6606056e00001371 APP clearance through CLU:TREM2 interaction. (Human) NCBITaxon:9606 gomodel:6606056e00001371/6606056e00001372 GO:0048018 receptor ligand activity GO:0097242 amyloid-beta clearance GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001371 APP clearance through CLU:TREM2 interaction. (Human) NCBITaxon:9606 gomodel:6606056e00001371/6606056e00001379 GO:0004888 transmembrane signaling receptor activity GO:0097242 amyloid-beta clearance GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001371 APP clearance through CLU:TREM2 interaction. (Human) NCBITaxon:9606 gomodel:6606056e00001371/6606056e00001393 GO:0030674 protein-macromolecule adaptor activity GO:0097242 amyloid-beta clearance GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001371 APP clearance through CLU:TREM2 interaction. (Human) NCBITaxon:9606 gomodel:6606056e00001371/6606056e00001405 GO:0004713 protein tyrosine kinase activity GO:0097242 amyloid-beta clearance GO:0005737 cytoplasm false UniProtKB:P04114 APOB Hsap 6606056e00001418 TREM2 activated by APOB. (Human) NCBITaxon:9606 gomodel:6606056e00001418/6606056e00001419 GO:0048018 receptor ligand activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001418 TREM2 activated by APOB. (Human) NCBITaxon:9606 gomodel:6606056e00001418/6606056e00001426 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001418 TREM2 activated by APOB. (Human) NCBITaxon:9606 gomodel:6606056e00001418/6606056e00001440 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001418 TREM2 activated by APOB. (Human) NCBITaxon:9606 gomodel:6606056e00001418/6606056e00001452 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:P02647 APOA1 Hsap 6606056e00001462 TREM2 activated by APOA1. (Human) NCBITaxon:9606 gomodel:6606056e00001462/6606056e00001463 GO:0048018 receptor ligand activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001462 TREM2 activated by APOA1. (Human) NCBITaxon:9606 gomodel:6606056e00001462/6606056e00001470 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001462 TREM2 activated by APOA1. (Human) NCBITaxon:9606 gomodel:6606056e00001462/6606056e00001484 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001462 TREM2 activated by APOA1. (Human) NCBITaxon:9606 gomodel:6606056e00001462/6606056e00001496 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:P02652 APOA2 Hsap 6606056e00001507 TREM2 activated by APOA2. (Human) NCBITaxon:9606 gomodel:6606056e00001507/6606056e00001508 GO:0048018 receptor ligand activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005576 extracellular region false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001507 TREM2 activated by APOA2. (Human) NCBITaxon:9606 gomodel:6606056e00001507/6606056e00001515 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001507 TREM2 activated by APOA2. (Human) NCBITaxon:9606 gomodel:6606056e00001507/6606056e00001529 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001507 TREM2 activated by APOA2. (Human) NCBITaxon:9606 gomodel:6606056e00001507/6606056e00001541 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001551 TREM2 activated by LDL. (Human) NCBITaxon:9606 gomodel:6606056e00001551/6606056e00001559 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001551 TREM2 activated by LDL. (Human) NCBITaxon:9606 gomodel:6606056e00001551/6606056e00001573 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001551 TREM2 activated by LDL. (Human) NCBITaxon:9606 gomodel:6606056e00001551/6606056e00001585 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:Q9NZC2 TREM2 Hsap 6606056e00001598 TREM2 activated by VLDL. (Human) NCBITaxon:9606 gomodel:6606056e00001598/6606056e00001599 GO:0004888 transmembrane signaling receptor activity GO:0071402 cellular response to lipoprotein particle stimulus GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 6606056e00001598 TREM2 activated by VLDL. (Human) NCBITaxon:9606 gomodel:6606056e00001598/6606056e00001610 GO:0030674 protein-macromolecule adaptor activity GO:1904646 cellular response to amyloid-beta GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 6606056e00001598 TREM2 activated by VLDL. (Human) NCBITaxon:9606 gomodel:6606056e00001598/6606056e00001622 GO:0004713 protein tyrosine kinase activity GO:1904646 cellular response to amyloid-beta GO:0005737 cytoplasm false UniProtKB:Q9P0J7 KCMF1 Hsap 6606056e00001669 Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001669/6606056e00001670 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q5T4S7 UBR4 Hsap 6606056e00001669 Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001669/6606056e00001677 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P49459 UBE2A Hsap 6606056e00001669 Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001669/6606056e00001685 GO:0061631 ubiquitin conjugating enzyme activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q147X3 NAA30 Hsap 6606056e00001669 Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001669/6606056e00001699 GO:0004596 protein-N-terminal amino-acid acetyltransferase activity GO:0050821 protein stabilization GO:0005737 cytoplasm false UniProtKB:P62081 RPS7 Hsap 6606056e00001669 Acetylation of N-terminus by NAA30 prevents ubiquitination and degradation by UBR4 and KCMF1 (Human). NCBITaxon:9606 gomodel:6606056e00001669/6606056e00001709 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0022626 cytosolic ribosome false UniProtKB:Q9P0J7 KCMF1 Hsap 6606056e00001745 UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress, leading to degradation of ubiquitinated proteins in autophagosomes (Human) NCBITaxon:9606 gomodel:6606056e00001745/6606056e00001746 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q5T4S7 UBR4 Hsap 6606056e00001745 UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress, leading to degradation of ubiquitinated proteins in autophagosomes (Human) NCBITaxon:9606 gomodel:6606056e00001745/6606056e00001753 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O95260 ATE1 Hsap 6606056e00001745 UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress, leading to degradation of ubiquitinated proteins in autophagosomes (Human) NCBITaxon:9606 gomodel:6606056e00001745/6606056e00001785 GO:0004057 arginyl-tRNA--protein transferase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q13501 SQSTM1 Hsap 6606056e00001745 UBR4 and KCMF1 ubiquitinate arginylated proteins in response to oxidative stress, leading to degradation of ubiquitinated proteins in autophagosomes (Human) NCBITaxon:9606 gomodel:6606056e00001745/6606056e00001795 GO:0030674 protein-macromolecule adaptor activity GO:0071211 protein targeting to vacuole involved in autophagy GO:0005776 autophagosome false UniProtKB:Q14154 DELE1 Hsap 6606056e00001890 Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). NCBITaxon:9606 gomodel:6606056e00001890/6606056e00001891 GO:0043539 protein serine/threonine kinase activator activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:Q96E52 OMA1 Hsap 6606056e00001890 Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). NCBITaxon:9606 gomodel:6606056e00001890/6606056e00001907 GO:0004222 metalloendopeptidase activity GO:0033554 cellular response to stress GO:0005758 mitochondrial intermembrane space false UniProtKB:Q9BQI3 EIF2AK1 Hsap 6606056e00001890 Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). NCBITaxon:9606 gomodel:6606056e00001890/6606056e00001925 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140468 HRI-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 6606056e00001890 Activation of mitophagy in response to mitochondrial damage via activation of EIF2AK1/HRI by DELE1 (Human). NCBITaxon:9606 gomodel:6606056e00001890/6606056e00001940 GO:0003674 molecular_function GO:0000423 mitophagy GO:0005739 mitochondrion false UniProtKB:P21854 CD72 Hsap 6606056e00002011 CD72 and BCR co-stimulation by sn/RNP self antigen (Human) NCBITaxon:9606 gomodel:6606056e00002011/6606056e00002014 GO:0004888 transmembrane signaling receptor activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07948 LYN Hsap 6606056e00002011 CD72 and BCR co-stimulation by sn/RNP self antigen (Human) NCBITaxon:9606 gomodel:6606056e00002011/6606056e00002040 GO:0004713 protein tyrosine kinase activity GO:0001782 B cell homeostasis GO:0005886 plasma membrane false UniProtKB:P29350 PTPN6 Hsap 6606056e00002011 CD72 and BCR co-stimulation by sn/RNP self antigen (Human) NCBITaxon:9606 gomodel:6606056e00002011/6606056e00002049 GO:0004725 protein tyrosine phosphatase activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005737 cytoplasm false GO:0019815 B cell receptor complex 6606056e00002011 CD72 and BCR co-stimulation by sn/RNP self antigen (Human) NCBITaxon:9606 gomodel:6606056e00002011/662af8fa00002857 GO:0004888 transmembrane signaling receptor activity GO:0050853 B cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P69723-PRO_0000042759 vif-Vif NCBITaxon:11706 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/6606056e00002525 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0030430 host cell cytoplasm false UniProtKB:Q93034 CUL5 Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/6606056e00002536 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9UBF6 RNF7 Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/6606056e00002541 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9HC16 APOBEC3G Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/6606056e00002546 GO:0004126 cytidine deaminase activity GO:0045087 innate immune response false UniProtKB:Q9UBF6 RNF7 Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/66187e4700000230 GO:0061663 NEDD8 ligase activity GO:0045116 protein neddylation false UniProtKB:O95376 ARIH2 Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/66187e4700000238 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q969M7 UBE2F Hsap 6606056e00002524 HIV-1 Vif protein hijacks a cullin-5-RING E3 ubiquitin-protein ligase to mediate ubiquitination and degradation of APOBEC3G (Human). NCBITaxon:9606 gomodel:6606056e00002524/66187e4700000310 GO:0061654 NEDD8 conjugating enzyme activity GO:0045116 protein neddylation false UniProtKB:Q96DX5 ASB9 Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000247 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q93034 CUL5 Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000253 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000256 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000263 GO:0061663 NEDD8 ligase activity GO:0045116 protein neddylation false UniProtKB:O95376 ARIH2 Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000267 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P12277 CKB Hsap 66187e4700000246 The CRL5(ASB9) complex mediates ubiquitination and degradation of CKB (Human). NCBITaxon:9606 gomodel:66187e4700000246/66187e4700000287 GO:0004111 creatine kinase activity GO:0046314 phosphocreatine biosynthetic process true phosphocreatine_shuttle UniProtKB:Q8WXH4 ASB11 Hsap 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000319 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005783 endoplasmic reticulum false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000326 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q93034 CUL5 Hsap 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000341 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P17861-2 XBP1 Hsap 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000355 GO:0003700 DNA-binding transcription factor activity GO:0030968 endoplasmic reticulum unfolded protein response GO:0005634 nucleus false UniProtKB:P55072 VCP Hsap 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000368 GO:0140036 ubiquitin-modified protein reader activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false GO:0005839 proteasome core complex 66187e4700000318 The CRL5(ASB11) complex mediates ubiquitination and degradation of BIK in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66187e4700000318/66187e4700000376 GO:0004175 endopeptidase activity GO:0010498 proteasomal protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8N884 CGAS Hsap 66187e4700000906 The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). NCBITaxon:9606 gomodel:66187e4700000906/66187e4700000957 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q6PJ21 SPSB3 Hsap 66187e4700000906 The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). NCBITaxon:9606 gomodel:66187e4700000906/66187e4700000995 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:Q93034 CUL5 Hsap 66187e4700000906 The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). NCBITaxon:9606 gomodel:66187e4700000906/66187e4700001011 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700000906 The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). NCBITaxon:9606 gomodel:66187e4700000906/66187e4700001018 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q86WV6 STING1 Hsap 66187e4700000906 The ECS(SPSB3) complex mediates ubiquitination and degradation of CGAS in the nucleus during mitotic interphase (Human). NCBITaxon:9606 gomodel:66187e4700000906/69729a3800007716 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:O95863 SNAI1 Hsap 66187e4700001030 The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001030/66187e4700001031 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001837 epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:P49841 GSK3B Hsap 66187e4700001030 The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001030/66187e4700001061 GO:0004674 protein serine/threonine kinase activity GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:Q6PJ21 SPSB3 Hsap 66187e4700001030 The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001030/66187e4700001070 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q93034 CUL5 Hsap 66187e4700001030 The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001030/66187e4700001082 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700001030 The ECS(SPSB3) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001030/66187e4700001091 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:O95863 SNAI1 Hsap 66187e4700001102 The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001102/66187e4700001103 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001837 epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:P49841 GSK3B Hsap 66187e4700001102 The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001102/66187e4700001113 GO:0004674 protein serine/threonine kinase activity GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0005634 nucleus false UniProtKB:Q86XK2 FBXO11 Hsap 66187e4700001102 The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001102/66187e4700001122 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 66187e4700001102 The SCF(FBXO11) complex mediates ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (Human). NCBITaxon:9606 gomodel:66187e4700001102/66187e4700001142 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9BQS7 HEPH Hsap 66187e4700001156 Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) NCBITaxon:9606 gomodel:66187e4700001156/66187e4700001157 GO:0004322 ferroxidase activity GO:0060586 multicellular organismal-level iron ion homeostasis GO:0016323 basolateral plasma membrane false UniProtKB:Q9NP59 SLC40A1 Hsap 66187e4700001156 Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) NCBITaxon:9606 gomodel:66187e4700001156/66187e4700001161 GO:0015093 ferrous iron transmembrane transporter activity GO:1903988 iron ion export across plasma membrane GO:0016323 basolateral plasma membrane false UniProtKB:P02787 TF Hsap 66187e4700001156 Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) NCBITaxon:9606 gomodel:66187e4700001156/66187e4700001168 GO:0034986 iron chaperone activity GO:0060586 multicellular organismal-level iron ion homeostasis GO:0005576 extracellular region false UniProtKB:P81172 HAMP Hsap 66187e4700001156 Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) NCBITaxon:9606 gomodel:66187e4700001156/66187e4700001219 GO:0005179 hormone activity GO:0060586 multicellular organismal-level iron ion homeostasis GO:0005576 extracellular region false UniProtKB:P02786 TFRC Hsap 66187e4700001156 Ferroportin/Hephaestin/Transferrin complex in iron absorption (Human) NCBITaxon:9606 gomodel:66187e4700001156/66187e4700001236 GO:0004998 transferrin receptor activity GO:0060586 multicellular organismal-level iron ion homeostasis GO:0005886 plasma membrane false UniProtKB:Q9Y6M1 IGF2BP2 Hsap 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001275 GO:1990247 N6-methyladenosine-containing RNA reader activity GO:0043489 RNA stabilization false UniProtKB:Q13263 TRIM28 Hsap 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001283 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false RNAcentral:URS000075C624_9606 URS000075C624_9606 Hsap 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001288 GO:0005515 protein binding GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:O75534 CSDE1 Hsap 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001297 GO:0003729 mRNA binding GO:0045727 positive regulation of translation false UniProtKB:P27361 MAPK3 Hsap 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001312 GO:0004707 MAP kinase activity GO:0070371 ERK1 and ERK2 cascade false GO:0036396 RNA N6-methyladenosine methyltransferase complex 66187e4700001274 N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1 and coordinates oncogenic RNA regulons in hepatocellular carcinoma. PMID:36354136. (Human) NCBITaxon:9606 gomodel:66187e4700001274/66187e4700001321 GO:1990931 mRNA N6-methyladenosine dioxygenase activity GO:0043489 RNA stabilization false UniProtKB:P01241 GH1 Hsap 66187e4700001597 The growth hormone receptor signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700001597/66187e4700001598 GO:0008083 growth factor activity GO:0060396 growth hormone receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P10912 GHR Hsap 66187e4700001597 The growth hormone receptor signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700001597/66187e4700001607 GO:0004903 growth hormone receptor activity GO:0060396 growth hormone receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 66187e4700001597 The growth hormone receptor signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700001597/66187e4700001621 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0060397 growth hormone receptor signaling pathway via JAK-STAT GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P51692 STAT5B Hsap 66187e4700001597 The growth hormone receptor signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700001597/66187e4700001630 GO:0003700 DNA-binding transcription factor activity GO:0060397 growth hormone receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P01241 GH1 Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001645 GO:0008083 growth factor activity GO:0060396 growth hormone receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P10912 GHR Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001654 GO:0004903 growth hormone receptor activity GO:0060396 growth hormone receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001661 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0060397 growth hormone receptor signaling pathway via JAK-STAT GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P51692 STAT5B Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001670 GO:0003700 DNA-binding transcription factor activity GO:0060397 growth hormone receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:O14508 SOCS2 Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001682 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001693 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q93034 CUL5 Hsap 66187e4700001644 Feedback regulation of growth hormone receptor signaling pathway via ubiquitination and degradation of GHR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700001644/66187e4700001705 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:O60674 JAK2 Hsap 66187e4700002082 The erythropoietin-mediated signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002082/66187e4700002092 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0038162 erythropoietin-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P51692 STAT5B Hsap 66187e4700002082 The erythropoietin-mediated signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002082/66187e4700002097 GO:0003700 DNA-binding transcription factor activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P19235 EPOR Hsap 66187e4700002082 The erythropoietin-mediated signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002082/66187e4700002109 GO:0004900 erythropoietin receptor activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P01588 EPO Hsap 66187e4700002082 The erythropoietin-mediated signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002082/66187e4700002119 GO:0005125 cytokine activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:O60674 JAK2 Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002130 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0038162 erythropoietin-mediated signaling pathway GO:0031234 extrinsic component of cytoplasmic side of plasma membrane false UniProtKB:P51692 STAT5B Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002135 GO:0003700 DNA-binding transcription factor activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P19235 EPOR Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002146 GO:0004900 erythropoietin receptor activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P01588 EPO Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002156 GO:0005125 cytokine activity GO:0038162 erythropoietin-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002660 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:O14508 SOCS2 Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002671 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q93034 CUL5 Hsap 66187e4700002129 Feedback regulation of erythropoietin-mediated signaling via ubiquitination and degradation of EPOR by the ECS(SOCS2) complex (Human). NCBITaxon:9606 gomodel:66187e4700002129/66187e4700002697 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P01579 IFNG Hsap 66187e4700002599 SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002599/66187e4700002600 GO:0005125 cytokine activity GO:0060333 type II interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q8WVN6 SECTM1 Hsap 66187e4700002599 SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002599/66187e4700002607 GO:0048018 receptor ligand activity GO:0002726 positive regulation of T cell cytokine production GO:0005886 plasma membrane false UniProtKB:P09564 CD7 Hsap 66187e4700002599 SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002599/66187e4700002617 GO:0004888 transmembrane signaling receptor activity GO:0002726 positive regulation of T cell cytokine production GO:0005886 plasma membrane false UniProtKB:P60568 IL2 Hsap 66187e4700002599 SECTM1-CD7 interaction leading to cytokine production upon T-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002599/66187e4700002629 GO:0005125 cytokine activity GO:0038110 interleukin-2-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P01024 C3 Hsap 66187e4700002637 CD21/FCRL5 receptor role in B-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002637/66187e4700002638 GO:0048018 receptor ligand activity GO:0042113 B cell activation GO:0005576 extracellular region false UniProtKB:P20023 CR2 Hsap 66187e4700002637 CD21/FCRL5 receptor role in B-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002637/66187e4700002647 GO:0004875 complement receptor activity GO:0042113 B cell activation GO:0005886 plasma membrane false UniProtKB:Q96RD9 FCRL5 Hsap 66187e4700002637 CD21/FCRL5 receptor role in B-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002637/66187e4700002851 GO:0015026 coreceptor activity GO:0042113 B cell activation GO:0005886 plasma membrane false UniProtKB:Q06187 BTK Hsap 66187e4700002637 CD21/FCRL5 receptor role in B-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002637/66187e4700002861 GO:0004713 protein tyrosine kinase activity GO:0042113 B cell activation GO:0005886 plasma membrane false UniProtKB:P16885 PLCG2 Hsap 66187e4700002637 CD21/FCRL5 receptor role in B-cell activation (Human) NCBITaxon:9606 gomodel:66187e4700002637/66187e4700002871 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0042113 B cell activation GO:0005886 plasma membrane false UniProtKB:P03200 BLLF1 NCBITaxon:10377 66187e4700002670 EBV entry into host cell via BLLF1-CR2 interaction (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:66187e4700002670/66187e4700002680 GO:0048018 receptor ligand activity GO:0046718 symbiont entry into host cell GO:0005886 plasma membrane false UniProtKB:P20023 CR2 Hsap 66187e4700002670 EBV entry into host cell via BLLF1-CR2 interaction (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:66187e4700002670/66187e4700002687 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0005886 plasma membrane false UniProtKB:P0DY56 IFNA1 Hsap 66187e4700002670 EBV entry into host cell via BLLF1-CR2 interaction (Human-Epstein-Barr virus) NCBITaxon:9606 gomodel:66187e4700002670/66187e4700002944 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P78509 RELN Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002705 GO:0048018 receptor ligand activity GO:0038026 reelin-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q14114-4 LRP8 Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002716 GO:0038025 reelin receptor activity GO:0038026 reelin-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P06241 FYN Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002727 GO:0004713 protein tyrosine kinase activity GO:0038026 reelin-mediated signaling pathway false UniProtKB:O75553 DAB1 Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002736 GO:0035591 signaling adaptor activity GO:0038026 reelin-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O14512 SOCS7 Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002746 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002756 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q93034 CUL5 Hsap 66187e4700002704 Inhibition of reelin signaling via ubiquitination and degradation of DAB1 by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex (Human). NCBITaxon:9606 gomodel:66187e4700002704/66187e4700002770 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P78509 RELN Hsap 66187e4700002778 The reelin signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002778/66187e4700002779 GO:0048018 receptor ligand activity GO:0038026 reelin-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q14114-4 LRP8 Hsap 66187e4700002778 The reelin signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002778/66187e4700002790 GO:0038025 reelin receptor activity GO:0038026 reelin-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P06241 FYN Hsap 66187e4700002778 The reelin signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002778/66187e4700002801 GO:0004713 protein tyrosine kinase activity GO:0038026 reelin-mediated signaling pathway false UniProtKB:O75553 DAB1 Hsap 66187e4700002778 The reelin signaling pathway (Human). NCBITaxon:9606 gomodel:66187e4700002778/66187e4700002810 GO:0035591 signaling adaptor activity GO:0038026 reelin-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P0DY56 IFNA1 Hsap 66187e4700002881 IFNA1-CR2 role in B-cell ISGs induction (Human) NCBITaxon:9606 gomodel:66187e4700002881/66187e4700002911 GO:0005125 cytokine activity GO:0060337 type I interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P20023 CR2 Hsap 66187e4700002881 IFNA1-CR2 role in B-cell ISGs induction (Human) NCBITaxon:9606 gomodel:66187e4700002881/66187e4700002918 GO:0004888 transmembrane signaling receptor activity GO:0060337 type I interferon-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P20591 MX1 Hsap 66187e4700002881 IFNA1-CR2 role in B-cell ISGs induction (Human) NCBITaxon:9606 gomodel:66187e4700002881/66187e4700002928 GO:0003924 GTPase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:P19525 EIF2AK2 Hsap 66187e4700002881 IFNA1-CR2 role in B-cell ISGs induction (Human) NCBITaxon:9606 gomodel:66187e4700002881/66187e4700002935 GO:0016301 kinase activity GO:0140374 antiviral innate immune response GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). NCBITaxon:9606 gomodel:662af8fa00000002/662af8fa00000003 GO:0061630 ubiquitin protein ligase activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:Q93034 CUL5 Hsap 662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). NCBITaxon:9606 gomodel:662af8fa00000002/662af8fa00000012 GO:0160072 ubiquitin ligase complex scaffold activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:O00762 UBE2C Hsap 662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). NCBITaxon:9606 gomodel:662af8fa00000002/662af8fa00000020 GO:0061631 ubiquitin conjugating enzyme activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:Q16763 UBE2S Hsap 662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). NCBITaxon:9606 gomodel:662af8fa00000002/662af8fa00000027 GO:0061631 ubiquitin conjugating enzyme activity GO:0070979 protein K11-linked ubiquitination false UniProtKB:Q9Y297 BTRC Hsap 662af8fa00000002 BTRC is ubiquitinated and degraded by a Cul5-RING ubiquitin ligase complex (Human). NCBITaxon:9606 gomodel:662af8fa00000002/662af8fa00000037 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q7Z402 TMC7 Hsap 662af8fa00000863 Negative regulation of PIEZO2 channel activity by TMC7 (Human) NCBITaxon:9606 gomodel:662af8fa00000863/662af8fa00000875 GO:0008200 ion channel inhibitor activity GO:0050954 sensory perception of mechanical stimulus GO:0043025 neuronal cell body false UniProtKB:Q9H5I5 PIEZO2 Hsap 662af8fa00000863 Negative regulation of PIEZO2 channel activity by TMC7 (Human) NCBITaxon:9606 gomodel:662af8fa00000863/662af8fa00000886 GO:0140135 mechanosensitive monoatomic cation channel activity GO:0009612 response to mechanical stimulus GO:0032809 neuronal cell body membrane false UniProtKB:P29466 CASP1 Hsap 662af8fa00002099 GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). NCBITaxon:9606 gomodel:662af8fa00002099/662af8fa00002150 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002099 GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). NCBITaxon:9606 gomodel:662af8fa00002099/662af8fa00002157 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002099 GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). NCBITaxon:9606 gomodel:662af8fa00002099/662af8fa00002191 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:Q9C0B5 ZDHHC5 Hsap 662af8fa00002099 GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). NCBITaxon:9606 gomodel:662af8fa00002099/662af8fa00002209 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0140639 positive regulation of pyroptotic inflammatory response false UniProtKB:Q9Y397 ZDHHC9 Hsap 662af8fa00002099 GSDMD palmitoylation by ZDHHC5 and ZDHHC9 promotes pyroptosis (Human). NCBITaxon:9606 gomodel:662af8fa00002099/662af8fa00002216 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0140639 positive regulation of pyroptotic inflammatory response false UniProtKB:P33681 CD80 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002333 GO:0048018 receptor ligand activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P42081 CD86 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002336 GO:0048018 receptor ligand activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002378 GO:0004888 transmembrane signaling receptor activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002389 GO:0030674 protein-macromolecule adaptor activity GO:0042110 T cell activation GO:0005737 cytoplasm false UniProtKB:P15498 VAV1 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002397 GO:0005085 guanyl-nucleotide exchange factor activity GO:0031295 T cell costimulation GO:0005737 cytoplasm false UniProtKB:Q07889 SOS1 Hsap 662af8fa00002332 CD28/GRB2 axis leading to RAS activation (Human) NCBITaxon:9606 gomodel:662af8fa00002332/662af8fa00002412 GO:0005085 guanyl-nucleotide exchange factor activity GO:0042110 T cell activation GO:0005737 cytoplasm false UniProtKB:P49662 CASP4 Hsap 662af8fa00002457 O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human) NCBITaxon:9606 gomodel:662af8fa00002457/662af8fa00002467 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002457 O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human) NCBITaxon:9606 gomodel:662af8fa00002457/662af8fa00002493 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002457 O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human) NCBITaxon:9606 gomodel:662af8fa00002457/662af8fa00002501 GO:0022829 wide pore channel activity GO:0070269 pyroptotic inflammatory response GO:0005886 plasma membrane false UniProtKB:O15294 OGT Hsap 662af8fa00002457 O-GlcNAcylation of GSDMD by OGT inhibits the non-canonical inflammasome assembly (Human) NCBITaxon:9606 gomodel:662af8fa00002457/662af8fa00002564 GO:0097363 protein O-acetylglucosaminyltransferase activity GO:0160076 negative regulation of non-canonical inflammasome complex assembly false UniProtKB:P49662 CASP4 Hsap 662af8fa00002657 Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) NCBITaxon:9606 gomodel:662af8fa00002657/662af8fa00002658 GO:0008289 lipid binding GO:0042742 defense response to bacterium GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 662af8fa00002657 Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) NCBITaxon:9606 gomodel:662af8fa00002657/662af8fa00002667 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P49662 CASP4 Hsap 662af8fa00002657 Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) NCBITaxon:9606 gomodel:662af8fa00002657/662af8fa00002678 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002657 Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) NCBITaxon:9606 gomodel:662af8fa00002657/662af8fa00002693 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 662af8fa00002657 Activation of the non-canonical inflammasome mediated by CASP4 upon lipopolysaccharide-binding can lead to blood-brain barrier breakdown (Human) NCBITaxon:9606 gomodel:662af8fa00002657/662af8fa00002701 GO:0022829 wide pore channel activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:Q9NYG2 ZDHHC3 Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001424 GO:0016409 palmitoyltransferase activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005794 Golgi apparatus false UniProtKB:P50591 TNFSF10 Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001433 GO:0005125 cytokine activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005576 extracellular region false UniProtKB:O00220 TNFRSF10A Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001440 GO:0038023 signaling receptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0044853 plasma membrane raft false UniProtKB:Q15628 TRADD Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001462 GO:0030674 protein-macromolecule adaptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13158 FADD Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001472 GO:0030674 protein-macromolecule adaptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14790 CASP8 Hsap 662af8fa00002877 TRAIL/TRAILR1 interaction leading to apoptosis NCBITaxon:9606 gomodel:662af8fa00002877/663d668500001482 GO:0004197 cysteine-type endopeptidase activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 663d668500000226 VIF-mediated inhibition of STING by PTPN6 (Human-HIV) NCBITaxon:9606 gomodel:663d668500000226/663d668500000238 GO:0035591 signaling adaptor activity GO:0002221 pattern recognition receptor signaling pathway GO:0000139 Golgi membrane false UniProtKB:Q9UHD2 TBK1 Hsap 663d668500000226 VIF-mediated inhibition of STING by PTPN6 (Human-HIV) NCBITaxon:9606 gomodel:663d668500000226/663d668500000250 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P42685 FRK Hsap 663d668500000226 VIF-mediated inhibition of STING by PTPN6 (Human-HIV) NCBITaxon:9606 gomodel:663d668500000226/663d668500000260 GO:0004713 protein tyrosine kinase activity GO:0005737 cytoplasm false UniProtKB:P69723 vif NCBITaxon:11706 663d668500000226 VIF-mediated inhibition of STING by PTPN6 (Human-HIV) NCBITaxon:9606 gomodel:663d668500000226/663d668500000266 GO:0030674 protein-macromolecule adaptor activity GO:0039537 symbiont-mediated suppression of cytoplasmic pattern recognition receptor signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:P29350 PTPN6 Hsap 663d668500000226 VIF-mediated inhibition of STING by PTPN6 (Human-HIV) NCBITaxon:9606 gomodel:663d668500000226/663d668500000280 GO:0004725 protein tyrosine phosphatase activity GO:0045824 negative regulation of innate immune response GO:0005737 cytoplasm false UniProtKB:P19438 TNFRSF1A Hsap 663d668500000296 Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) NCBITaxon:9606 gomodel:663d668500000296/663d668500000398 GO:0038023 signaling receptor activity GO:0033209 tumor necrosis factor-mediated signaling pathway false UniProtKB:Q15628 TRADD Hsap 663d668500000296 Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) NCBITaxon:9606 gomodel:663d668500000296/663d668500000503 GO:0035591 signaling adaptor activity GO:0033209 tumor necrosis factor-mediated signaling pathway false UniProtKB:Q12933 TRAF2 Hsap 663d668500000296 Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) NCBITaxon:9606 gomodel:663d668500000296/663d668500000509 GO:0035591 signaling adaptor activity GO:0033209 tumor necrosis factor-mediated signaling pathway false UniProtKB:P01375 TNF Hsap 663d668500000296 Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) NCBITaxon:9606 gomodel:663d668500000296/663d668500000515 GO:0005125 cytokine activity GO:0033209 tumor necrosis factor-mediated signaling pathway false UniProtKB:Q8IU68 TMC8 Hsap 663d668500000296 Regulation of TNF-alpha-mediated signaling pathway by TMC8 (Human) NCBITaxon:9606 gomodel:663d668500000296/663d668500000523 GO:0140311 protein sequestering activity GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway false UniProtKB:P35790 CHKA Hsap 663d668500000606 Phosphatidylcholine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000606/663d668500000607 GO:0004103 choline kinase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005829 cytosol false UniProtKB:P49585 PCYT1A Hsap 663d668500000606 Phosphatidylcholine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000606/663d668500000616 GO:0004105 choline-phosphate cytidylyltransferase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8WUD6 CHPT1 Hsap 663d668500000606 Phosphatidylcholine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000606/663d668500000623 GO:0004142 diacylglycerol cholinephosphotransferase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0000139 Golgi membrane false UniProtKB:Q9Y5Y0 FLVCR1 Hsap 663d668500000606 Phosphatidylcholine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000606/663d668500000658 GO:0015220 choline transmembrane transporter activity GO:0008654 phospholipid biosynthetic process GO:0005886 plasma membrane false UniProtKB:Q9HBU6 ETNK1 Hsap 663d668500000695 Phosphatidylethanolamine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000695/663d668500000722 GO:0004305 ethanolamine kinase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005737 cytoplasm false UniProtKB:Q99447 PCYT2 Hsap 663d668500000695 Phosphatidylethanolamine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000695/663d668500000729 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9C0D9 SELENOI Hsap 663d668500000695 Phosphatidylethanolamine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000695/663d668500000737 GO:0004307 ethanolaminephosphotransferase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9Y5Y0 FLVCR1 Hsap 663d668500000695 Phosphatidylethanolamine biosynthetic pathway (Human). NCBITaxon:9606 gomodel:663d668500000695/663d668500000754 GO:0034228 ethanolamine transmembrane transporter activity GO:0008654 phospholipid biosynthetic process GO:0005886 plasma membrane false UniProtKB:Q9HBU6 ETNK1 Hsap 663d668500001089 SELENOI is involved in ether lipid homeostasis and myelination (Human). NCBITaxon:9606 gomodel:663d668500001089/663d668500001090 GO:0004305 ethanolamine kinase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005737 cytoplasm false UniProtKB:Q99447 PCYT2 Hsap 663d668500001089 SELENOI is involved in ether lipid homeostasis and myelination (Human). NCBITaxon:9606 gomodel:663d668500001089/663d668500001097 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity GO:0006646 phosphatidylethanolamine biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9C0D9 SELENOI Hsap 663d668500001089 SELENOI is involved in ether lipid homeostasis and myelination (Human). NCBITaxon:9606 gomodel:663d668500001089/663d668500001105 GO:0004307 ethanolaminephosphotransferase activity GO:0008611 ether lipid biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:P35790 CHKA Hsap 663d668500001188 FLVCR2 mediates choline uptake at the blood-brain-barrier (Human). NCBITaxon:9606 gomodel:663d668500001188/663d668500001189 GO:0004103 choline kinase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005829 cytosol false UniProtKB:P49585 PCYT1A Hsap 663d668500001188 FLVCR2 mediates choline uptake at the blood-brain-barrier (Human). NCBITaxon:9606 gomodel:663d668500001188/663d668500001198 GO:0004105 choline-phosphate cytidylyltransferase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8WUD6 CHPT1 Hsap 663d668500001188 FLVCR2 mediates choline uptake at the blood-brain-barrier (Human). NCBITaxon:9606 gomodel:663d668500001188/663d668500001205 GO:0004142 diacylglycerol cholinephosphotransferase activity GO:0006656 phosphatidylcholine biosynthetic process GO:0000139 Golgi membrane false UniProtKB:Q9UPI3 FLVCR2 Hsap 663d668500001188 FLVCR2 mediates choline uptake at the blood-brain-barrier (Human). NCBITaxon:9606 gomodel:663d668500001188/663d668500001215 GO:0015220 choline transmembrane transporter activity GO:0150104 transport across blood-brain barrier GO:0005886 plasma membrane false UniProtKB:P29466 CASP1 Hsap 663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). NCBITaxon:9606 gomodel:663d668500001246/663d668500001303 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). NCBITaxon:9606 gomodel:663d668500001246/663d668500001343 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). NCBITaxon:9606 gomodel:663d668500001246/663d668500001350 GO:0070273 phosphatidylinositol-4-phosphate binding GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P57764-PRO_0000437526 GSDMD-GSDMD-NT Hsap 663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). NCBITaxon:9606 gomodel:663d668500001246/663d668500001359 GO:0022829 wide pore channel activity GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:Q92982 NINJ1 Hsap 663d668500001246 Pyroptotic cell death mediated by GSDMD and NINJ1 (Human). NCBITaxon:9606 gomodel:663d668500001246/663d668500001406 GO:0140912 membrane destabilizing activity GO:0141201 pyroptotic cell death GO:0005886 plasma membrane false UniProtKB:P50591 TNFSF10 Hsap 663d668500001492 TRAIL/TRAILR2 interaction leading to apoptosis NCBITaxon:9606 gomodel:663d668500001492/663d668500001502 GO:0005125 cytokine activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005576 extracellular region false UniProtKB:O14763 TNFRSF10B Hsap 663d668500001492 TRAIL/TRAILR2 interaction leading to apoptosis NCBITaxon:9606 gomodel:663d668500001492/663d668500001509 GO:0038023 signaling receptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15628 TRADD Hsap 663d668500001492 TRAIL/TRAILR2 interaction leading to apoptosis NCBITaxon:9606 gomodel:663d668500001492/663d668500001520 GO:0030674 protein-macromolecule adaptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13158 FADD Hsap 663d668500001492 TRAIL/TRAILR2 interaction leading to apoptosis NCBITaxon:9606 gomodel:663d668500001492/663d668500001530 GO:0030674 protein-macromolecule adaptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14790 CASP8 Hsap 663d668500001492 TRAIL/TRAILR2 interaction leading to apoptosis NCBITaxon:9606 gomodel:663d668500001492/663d668500001540 GO:0004197 cysteine-type endopeptidase activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13158 FADD Hsap 663d668500001551 FASL-FAS interaction leading to apoptosis (human) NCBITaxon:9606 gomodel:663d668500001551/663d668500001579 GO:0030674 protein-macromolecule adaptor activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0005737 cytoplasm false UniProtKB:Q14790 CASP8 Hsap 663d668500001551 FASL-FAS interaction leading to apoptosis (human) NCBITaxon:9606 gomodel:663d668500001551/663d668500001589 GO:0004197 cysteine-type endopeptidase activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0005737 cytoplasm false UniProtKB:P25445 FAS Hsap 663d668500001551 FASL-FAS interaction leading to apoptosis (human) NCBITaxon:9606 gomodel:663d668500001551/663d668500001647 GO:0038023 signaling receptor activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0005886 plasma membrane false UniProtKB:P48023 FASLG Hsap 663d668500001551 FASL-FAS interaction leading to apoptosis (human) NCBITaxon:9606 gomodel:663d668500001551/663d668500001652 GO:0005125 cytokine activity GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0005576 extracellular region false UniProtKB:P29965 CD40LG Hsap 663d668500001599 CD40-CD40L distal activation of TRAF6 (Human) NCBITaxon:9606 gomodel:663d668500001599/663d668500001600 GO:0005125 cytokine activity GO:0023035 CD40 signaling pathway GO:0005576 extracellular region false UniProtKB:P25942 CD40 Hsap 663d668500001599 CD40-CD40L distal activation of TRAF6 (Human) NCBITaxon:9606 gomodel:663d668500001599/663d668500001607 GO:0038023 signaling receptor activity GO:0023035 CD40 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 663d668500001599 CD40-CD40L distal activation of TRAF6 (Human) NCBITaxon:9606 gomodel:663d668500001599/663d668500001617 GO:0030674 protein-macromolecule adaptor activity GO:0023035 CD40 signaling pathway GO:0005737 cytoplasm false UniProtKB:P29965 CD40LG Hsap 663d668500001704 CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human) NCBITaxon:9606 gomodel:663d668500001704/663d668500001705 GO:0005125 cytokine activity GO:0023035 CD40 signaling pathway GO:0005576 extracellular region false UniProtKB:P25942 CD40 Hsap 663d668500001704 CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human) NCBITaxon:9606 gomodel:663d668500001704/663d668500001712 GO:0038023 signaling receptor activity GO:0023035 CD40 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q12933 TRAF2 Hsap 663d668500001704 CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human) NCBITaxon:9606 gomodel:663d668500001704/663d668500001734 GO:0061630 ubiquitin protein ligase activity GO:0023035 CD40 signaling pathway GO:0005737 cytoplasm false UniProtKB:O00463 TRAF5 Hsap 663d668500001704 CD40-CD40L proximal activation of TRAF2 and TRAF5 (Human) NCBITaxon:9606 gomodel:663d668500001704/663d668500001742 GO:0061630 ubiquitin protein ligase activity GO:0023035 CD40 signaling pathway GO:0005737 cytoplasm false UniProtKB:O60602 TLR5 Hsap 663d668500002770 Bacterial flagellin recognition by TLR5 (Human) NCBITaxon:9606 gomodel:663d668500002770/663d668500002771 GO:0038187 pattern recognition receptor activity GO:0034146 toll-like receptor 5 signaling pathway GO:0005886 plasma membrane false UniProtKB:P06179 fliC SALTY 663d668500002770 Bacterial flagellin recognition by TLR5 (Human) NCBITaxon:9606 gomodel:663d668500002770/663d668500002778 GO:0048018 receptor ligand activity GO:0005576 extracellular region false UniProtKB:Q99836 MYD88 Hsap 663d668500002770 Bacterial flagellin recognition by TLR5 (Human) NCBITaxon:9606 gomodel:663d668500002770/663d668500002784 GO:0035591 signaling adaptor activity GO:0034146 toll-like receptor 5 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q13705 ACVR2B Hsap 663d668500002824 Activin E signaling pathway leading to inhibition of adipose tissue development (Human) NCBITaxon:9606 gomodel:663d668500002824/663d668500003135 GO:0016362 activin receptor activity, type II GO:1904178 negative regulation of adipose tissue development GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 663d668500002824 Activin E signaling pathway leading to inhibition of adipose tissue development (Human) NCBITaxon:9606 gomodel:663d668500002824/678073a900001657 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0032924 activin receptor signaling pathway GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 663d668500002824 Activin E signaling pathway leading to inhibition of adipose tissue development (Human) NCBITaxon:9606 gomodel:663d668500002824/678073a900001664 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0032924 activin receptor signaling pathway GO:0005634 nucleus false UniProtKB:P58166 INHBE Hsap 663d668500002824 Activin E signaling pathway leading to inhibition of adipose tissue development (Human) NCBITaxon:9606 gomodel:663d668500002824/67b1629100002685 GO:0005125 cytokine activity GO:1904178 negative regulation of adipose tissue development GO:0005576 extracellular region false UniProtKB:Q8NER5 ACVR1C Hsap 663d668500002824 Activin E signaling pathway leading to inhibition of adipose tissue development (Human) NCBITaxon:9606 gomodel:663d668500002824/67b1629100002692 GO:0016361 activin receptor activity, type I GO:1904178 negative regulation of adipose tissue development GO:0005886 plasma membrane false UniProtKB:P37173 TGFBR2 Hsap 663d668500003144 TGFB1-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003144/663d668500003145 GO:0005026 transforming growth factor beta receptor activity, type II GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P36897 TGFBR1 Hsap 663d668500003144 TGFB1-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003144/663d668500003152 GO:0005025 transforming growth factor beta receptor activity, type I GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 663d668500003144 TGFB1-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003144/663d668500003164 GO:0003700 DNA-binding transcription factor activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005634 nucleus false UniProtKB:P01137 TGFB1 Hsap 663d668500003144 TGFB1-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003144/663d668500003172 GO:0005125 cytokine activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P37173 TGFBR2 Hsap 663d668500003182 TGFB2-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003182/663d668500003183 GO:0005026 transforming growth factor beta receptor activity, type II GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P36897 TGFBR1 Hsap 663d668500003182 TGFB2-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003182/663d668500003190 GO:0005025 transforming growth factor beta receptor activity, type I GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 663d668500003182 TGFB2-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003182/663d668500003202 GO:0003700 DNA-binding transcription factor activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005634 nucleus false UniProtKB:P61812 TGFB2 Hsap 663d668500003182 TGFB2-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003182/663d668500003222 GO:0005125 cytokine activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P37173 TGFBR2 Hsap 663d668500003232 TGFB3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003232/663d668500003233 GO:0005026 transforming growth factor beta receptor activity, type II GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P36897 TGFBR1 Hsap 663d668500003232 TGFB3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003232/663d668500003240 GO:0005025 transforming growth factor beta receptor activity, type I GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 663d668500003232 TGFB3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003232/663d668500003252 GO:0003700 DNA-binding transcription factor activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005634 nucleus false UniProtKB:P10600 TGFB3 Hsap 663d668500003232 TGFB3-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:663d668500003232/663d668500003270 GO:0005125 cytokine activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q9BRJ6 CHLSN Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000553 GO:0005179 hormone activity GO:0045541 negative regulation of cholesterol biosynthetic process GO:0005576 extracellular region false UniProtKB:Q96CH1 GPR146 Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000562 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000574 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P17612 PRKACA Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000584 GO:0004691 cAMP-dependent protein kinase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P28482 MAPK1 Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000594 GO:0004707 MAP kinase activity GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005737 cytoplasm false UniProtKB:Q12772 SREBF2 Hsap 665912ed00000552 Cholesterol synthesis regulation by Cholesin and GPR146 NCBITaxon:9606 gomodel:665912ed00000552/665912ed00000602 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005634 nucleus false UniProtKB:Q9GZQ6 NPFFR1 Hsap 665912ed00001822 GPCR NPFFR1 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001822/665912ed00001823 GO:0008188 neuropeptide receptor activity GO:0007218 neuropeptide signaling pathway GO:0005886 plasma membrane false UniProtKB:O15130 NPFF Hsap 665912ed00001822 GPCR NPFFR1 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001822/665912ed00001830 GO:0160041 neuropeptide activity GO:0007218 neuropeptide signaling pathway GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 665912ed00001822 GPCR NPFFR1 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001822/665912ed00001841 GO:0003925 G protein activity GO:0007218 neuropeptide signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9GZQ6 NPFFR1 Hsap 665912ed00001850 GPCR NPFFR1 activation by neuropeptides RFRP-1 and RFRP-3. (Human) NCBITaxon:9606 gomodel:665912ed00001850/665912ed00001851 GO:0008188 neuropeptide receptor activity GO:0007218 neuropeptide signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9HCQ7 NPVF Hsap 665912ed00001850 GPCR NPFFR1 activation by neuropeptides RFRP-1 and RFRP-3. (Human) NCBITaxon:9606 gomodel:665912ed00001850/665912ed00001858 GO:0160041 neuropeptide activity GO:0007218 neuropeptide signaling pathway GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 665912ed00001850 GPCR NPFFR1 activation by neuropeptides RFRP-1 and RFRP-3. (Human) NCBITaxon:9606 gomodel:665912ed00001850/665912ed00001869 GO:0003925 G protein activity GO:0007218 neuropeptide signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y5X5 NPFFR2 Hsap 665912ed00001925 GPCR NPFFR2 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001925/665912ed00001926 GO:0008188 neuropeptide receptor activity GO:0007218 neuropeptide signaling pathway GO:0005886 plasma membrane false UniProtKB:O15130 NPFF Hsap 665912ed00001925 GPCR NPFFR2 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001925/665912ed00001933 GO:0160041 neuropeptide activity GO:0007218 neuropeptide signaling pathway GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 665912ed00001925 GPCR NPFFR2 activation by neuropeptide NPFF. (Human) NCBITaxon:9606 gomodel:665912ed00001925/665912ed00001944 GO:0003925 G protein activity GO:0007218 neuropeptide signaling pathway GO:0005737 cytoplasm false UniProtKB:P07204 THBD Hsap 665912ed00003542 Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003542/665912ed00003552 GO:0038023 signaling receptor activity GO:0030195 negative regulation of blood coagulation GO:0005886 plasma membrane false UniProtKB:P00734 F2 Hsap 665912ed00003542 Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003542/665912ed00003560 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P04070 PROC Hsap 665912ed00003542 Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003542/665912ed00003568 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:Q15389 ANGPT1 Hsap 665912ed00003542 Angiopoietin-1-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003542/665912ed00003584 GO:0048018 receptor ligand activity GO:0050820 positive regulation of coagulation GO:0005576 extracellular region false UniProtKB:P07204 THBD Hsap 665912ed00003594 Angiopoietin-2-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003594/665912ed00003595 GO:0038023 signaling receptor activity GO:0030195 negative regulation of blood coagulation GO:0005886 plasma membrane false UniProtKB:P00734 F2 Hsap 665912ed00003594 Angiopoietin-2-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003594/665912ed00003602 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P04070 PROC Hsap 665912ed00003594 Angiopoietin-2-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003594/665912ed00003610 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:O15123 ANGPT2 Hsap 665912ed00003594 Angiopoietin-2-Thrombomodulin pair inhibiting Protein C activation (Human) NCBITaxon:9606 gomodel:665912ed00003594/665912ed00003626 GO:0048018 receptor ligand activity GO:0050820 positive regulation of coagulation GO:0005576 extracellular region false UniProtKB:P07204 THBD Hsap 666b894f00000010 PF4-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000010/666b894f00000011 GO:0038023 signaling receptor activity GO:0030195 negative regulation of blood coagulation GO:0005886 plasma membrane false UniProtKB:P00734 F2 Hsap 666b894f00000010 PF4-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000010/666b894f00000018 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P04070 PROC Hsap 666b894f00000010 PF4-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000010/666b894f00000026 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P02776 PF4 Hsap 666b894f00000010 PF4-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000010/666b894f00000042 GO:0048018 receptor ligand activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:Q9H8L6 MMRN2 Hsap 666b894f00000196 CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human) NCBITaxon:9606 gomodel:666b894f00000196/666b894f00000197 GO:0048018 receptor ligand activity GO:0001525 angiogenesis GO:0005576 extracellular region false UniProtKB:Q9NPY3 CD93 Hsap 666b894f00000196 CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human) NCBITaxon:9606 gomodel:666b894f00000196/666b894f00000204 GO:0038023 signaling receptor activity GO:0001525 angiogenesis GO:0005886 plasma membrane false UniProtKB:P05556 ITGB1 Hsap 666b894f00000196 CD93/Multimerin-2/β1 integrin complex function in angiogenesis (Human) NCBITaxon:9606 gomodel:666b894f00000196/666b894f00000215 GO:0015026 coreceptor activity GO:0001525 angiogenesis GO:0005886 plasma membrane false UniProtKB:P07204 THBD Hsap 666b894f00000232 Thrombin-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000232/666b894f00000233 GO:0038023 signaling receptor activity GO:0030195 negative regulation of blood coagulation GO:0005886 plasma membrane false UniProtKB:P00734 F2 Hsap 666b894f00000232 Thrombin-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000232/666b894f00000240 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P04070 PROC Hsap 666b894f00000232 Thrombin-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000232/666b894f00000248 GO:0004252 serine-type endopeptidase activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P00734 F2 Hsap 666b894f00000232 Thrombin-Thrombomodulin pair activating Protein C activation (Human) NCBITaxon:9606 gomodel:666b894f00000232/666b894f00000274 GO:0048018 receptor ligand activity GO:0030195 negative regulation of blood coagulation GO:0005576 extracellular region false UniProtKB:P26842 CD27 Hsap 666b894f00000352 CD70-CD27 ligand receptor in T cell activation (Human) NCBITaxon:9606 gomodel:666b894f00000352/666b894f00000354 GO:0004888 transmembrane signaling receptor activity GO:0160162 CD27 signaling pathway GO:0005886 plasma membrane false UniProtKB:P32970 CD70 Hsap 666b894f00000352 CD70-CD27 ligand receptor in T cell activation (Human) NCBITaxon:9606 gomodel:666b894f00000352/666b894f00000361 GO:0048018 receptor ligand activity GO:0160162 CD27 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q12933 TRAF2 Hsap 666b894f00000352 CD70-CD27 ligand receptor in T cell activation (Human) NCBITaxon:9606 gomodel:666b894f00000352/666b894f00000590 GO:0030674 protein-macromolecule adaptor activity GO:0160162 CD27 signaling pathway GO:0005737 cytoplasm false UniProtKB:P29350 PTPN6 Hsap 666b894f00000352 CD70-CD27 ligand receptor in T cell activation (Human) NCBITaxon:9606 gomodel:666b894f00000352/666b894f00000678 GO:0004725 protein tyrosine phosphatase activity GO:0160162 CD27 signaling pathway GO:0005737 cytoplasm false UniProtKB:P06239 LCK Hsap 666b894f00000352 CD70-CD27 ligand receptor in T cell activation (Human) NCBITaxon:9606 gomodel:666b894f00000352/666b894f00001585 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0160162 CD27 signaling pathway GO:0005886 plasma membrane false UniProtKB:P08908 HTR1A Hsap 666b894f00000484 HTR1A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000484/666b894f00000486 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00000484 HTR1A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000484/666b894f00000487 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 666b894f00000484 HTR1A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000484/666b894f00000488 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P28221 HTR1D Hsap 666b894f00000518 HTR1D-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000518/666b894f00000519 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00000518 HTR1D-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000518/666b894f00000520 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 666b894f00000518 HTR1D-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000518/666b894f00000521 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P28566 HTR1E Hsap 666b894f00000542 HTR1E-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000542/666b894f00000543 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00000542 HTR1E-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000542/666b894f00000544 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 666b894f00000542 HTR1E-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000542/666b894f00000545 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P30939 HTR1F Hsap 666b894f00000566 HTR1F-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000566/666b894f00000567 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00000566 HTR1F-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000566/666b894f00000568 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 666b894f00000566 HTR1F-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000566/666b894f00000569 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P28222 HTR1B Hsap 666b894f00000989 HTR1B-mediated serotonin signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000989/666b894f00000990 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00000989 HTR1B-mediated serotonin signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000989/666b894f00000991 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 666b894f00000989 HTR1B-mediated serotonin signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00000989/666b894f00000992 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P28223 HTR2A Hsap 666b894f00001077 HTR2A-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001077/666b894f00001079 GO:0001587 Gq/11-coupled serotonin receptor activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 666b894f00001077 HTR2A-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001077/666b894f00001080 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 666b894f00001077 HTR2A-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001077/666b894f00001081 GO:0003925 G protein activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 666b894f00001139 PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) NCBITaxon:9606 gomodel:666b894f00001139/666b894f00001146 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P35408 PTGER4 Hsap 666b894f00001139 PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) NCBITaxon:9606 gomodel:666b894f00001139/666b894f00001176 GO:0004957 prostaglandin E receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9BSK4 FEM1A Hsap 666b894f00001139 PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) NCBITaxon:9606 gomodel:666b894f00001139/666b894f00001193 GO:0060090 molecular adaptor activity GO:0050728 negative regulation of inflammatory response GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 666b894f00001139 PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) NCBITaxon:9606 gomodel:666b894f00001139/666b894f00001206 GO:0140311 protein sequestering activity GO:0050728 negative regulation of inflammatory response GO:0005737 cytoplasm false UniProtKB:P41279 MAP3K8 Hsap 666b894f00001139 PTGER4, prostaglandin E2 receptor involved in negative regulation of inflammatory response in macrophages. (Human) NCBITaxon:9606 gomodel:666b894f00001139/666b894f00001218 GO:0004709 MAP kinase kinase kinase activity GO:0000165 MAPK cascade GO:0005737 cytoplasm false UniProtKB:P41595 HTR2B Hsap 666b894f00001459 HTR2B-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001459/666b894f00001460 GO:0001587 Gq/11-coupled serotonin receptor activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 666b894f00001459 HTR2B-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001459/666b894f00001461 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 666b894f00001459 HTR2B-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:666b894f00001459/666b894f00001462 GO:0003925 G protein activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P28335 HTR2C Hsap 666b894f00001488 HTR2C-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:666b894f00001488/666b894f00001489 GO:0001587 Gq/11-coupled serotonin receptor activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 666b894f00001488 HTR2C-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:666b894f00001488/666b894f00001491 GO:0003925 G protein activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 666b894f00001488 HTR2C-mediated serotonin signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:666b894f00001488/667dfe8d00000776 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13639 HTR4 Hsap 666b894f00001546 "HTR4-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00001546/666b894f00001547 GO:0004993 G protein-coupled serotonin receptor activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 666b894f00001546 "HTR4-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00001546/666b894f00001551 GO:0003925 G protein activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00001546 "HTR4-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00001546/666b894f00001553 GO:0004016 adenylate cyclase activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway false UniProtKB:P47898 HTR5A Hsap 666b894f00001836 HTR5A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00001836/666b894f00001837 GO:0001586 Gi/o-coupled serotonin receptor activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00001836 HTR5A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00001836/666b894f00001838 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 666b894f00001836 HTR5A-mediated serotonin signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) (Human). NCBITaxon:9606 gomodel:666b894f00001836/666b894f00001839 GO:0003925 G protein activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P50406 HTR6 Hsap 666b894f00002018 "HTR6-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002018/666b894f00002019 GO:0004993 G protein-coupled serotonin receptor activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 666b894f00002018 "HTR6-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002018/666b894f00002021 GO:0003925 G protein activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00002018 "HTR6-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002018/666b894f00002023 GO:0004016 adenylate cyclase activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway false UniProtKB:P34969 HTR7 Hsap 666b894f00002043 "HTR7-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002043/666b894f00002044 GO:0004993 G protein-coupled serotonin receptor activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 666b894f00002043 "HTR7-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002043/666b894f00002046 GO:0003925 G protein activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 666b894f00002043 "HTR7-mediated serotonin signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:666b894f00002043/666b894f00002048 GO:0004016 adenylate cyclase activity GO:0007192 adenylate cyclase-activating serotonin receptor signaling pathway false UniProtKB:Q01973 ROR1 Hsap 666b894f00002484 ROR1 activation by IGFB5 leading to cell proliferation (Human) NCBITaxon:9606 gomodel:666b894f00002484/666b894f00002485 GO:0038023 signaling receptor activity GO:0008283 cell population proliferation GO:0005886 plasma membrane false UniProtKB:P24593 IGFBP5 Hsap 666b894f00002484 ROR1 activation by IGFB5 leading to cell proliferation (Human) NCBITaxon:9606 gomodel:666b894f00002484/666b894f00002492 GO:0048018 receptor ligand activity GO:0008283 cell population proliferation GO:0005576 extracellular region false UniProtKB:P04626 ERBB2 Hsap 666b894f00002484 ROR1 activation by IGFB5 leading to cell proliferation (Human) NCBITaxon:9606 gomodel:666b894f00002484/666b894f00002502 GO:0004713 protein tyrosine kinase activity GO:0008283 cell population proliferation GO:0005886 plasma membrane false UniProtKB:P16220 CREB1 Hsap 666b894f00002484 ROR1 activation by IGFB5 leading to cell proliferation (Human) NCBITaxon:9606 gomodel:666b894f00002484/666b894f00002510 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005634 nucleus false UniProtKB:Q96JA3 PLEKHA8 Hsap 666b894f00002535 Glucosylceramide-transfer activity of PLEKHA8 from cis-golgi to trans-golgi network (Human) NCBITaxon:9606 gomodel:666b894f00002535/666b894f00002536 GO:0140340 cerebroside transfer activity GO:0001576 globoside biosynthetic process GO:0005829 cytosol false UniProtKB:P09326 CD48 Hsap 667dfe8d00000011 CD48-CD244 ligand receptor binding in NK cell activation (Human) NCBITaxon:9606 gomodel:667dfe8d00000011/667dfe8d00000243 GO:0048018 receptor ligand activity GO:0030101 natural killer cell activation GO:0045121 membrane raft false UniProtKB:Q9BZW8 CD244 Hsap 667dfe8d00000011 CD48-CD244 ligand receptor binding in NK cell activation (Human) NCBITaxon:9606 gomodel:667dfe8d00000011/667dfe8d00000258 GO:0038023 signaling receptor activity GO:0030101 natural killer cell activation GO:0045121 membrane raft false UniProtKB:O60880 SH2D1A Hsap 667dfe8d00000011 CD48-CD244 ligand receptor binding in NK cell activation (Human) NCBITaxon:9606 gomodel:667dfe8d00000011/667dfe8d00000313 GO:0030674 protein-macromolecule adaptor activity GO:0030101 natural killer cell activation GO:0005737 cytoplasm false UniProtKB:P06241 FYN Hsap 667dfe8d00000011 CD48-CD244 ligand receptor binding in NK cell activation (Human) NCBITaxon:9606 gomodel:667dfe8d00000011/667dfe8d00000693 GO:0004713 protein tyrosine kinase activity GO:0030101 natural killer cell activation GO:0045121 membrane raft false UniProtKB:P15498 VAV1 Hsap 667dfe8d00000011 CD48-CD244 ligand receptor binding in NK cell activation (Human) NCBITaxon:9606 gomodel:667dfe8d00000011/667dfe8d00000816 GO:0005085 guanyl-nucleotide exchange factor activity GO:0030101 natural killer cell activation GO:0005737 cytoplasm false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000012 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000012/667dfe8d00000013 GO:0001594 trace-amine receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:P63092 GNAS Hsap 667dfe8d00000012 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000012/667dfe8d00000015 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 667dfe8d00000012 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000012/667dfe8d00000017 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000048 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by cadaverine (Human). NCBITaxon:9606 gomodel:667dfe8d00000048/667dfe8d00000049 GO:0001594 trace-amine receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:O43306 ADCY6 Hsap 667dfe8d00000048 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by cadaverine (Human). NCBITaxon:9606 gomodel:667dfe8d00000048/667dfe8d00000050 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 667dfe8d00000048 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by cadaverine (Human). NCBITaxon:9606 gomodel:667dfe8d00000048/667dfe8d00000051 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000109 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by cyclohexylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000109/667dfe8d00000110 GO:0001594 trace-amine receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:Q01970 PLCB3 Hsap 667dfe8d00000109 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by cyclohexylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000109/667dfe8d00000111 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 667dfe8d00000109 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by cyclohexylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000109/667dfe8d00000112 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000146 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000146/667dfe8d00000147 GO:0001594 trace-amine receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:Q01970 PLCB3 Hsap 667dfe8d00000146 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000146/667dfe8d00000148 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 667dfe8d00000146 TAAR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000146/667dfe8d00000149 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000179 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000179/667dfe8d00000180 GO:0001594 trace-amine receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:O43306 ADCY6 Hsap 667dfe8d00000179 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000179/667dfe8d00000181 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 667dfe8d00000179 TAAR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by trimethylamine (Human). NCBITaxon:9606 gomodel:667dfe8d00000179/667dfe8d00000182 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q96RJ0 TAAR1 Hsap 667dfe8d00000211 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000211/667dfe8d00000212 GO:0001594 trace-amine receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0012505 endomembrane system false UniProtKB:P63092 GNAS Hsap 667dfe8d00000211 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000211/667dfe8d00000214 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 667dfe8d00000211 "TAAR1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:667dfe8d00000211/667dfe8d00000216 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P18065 IGFBP2 Hsap 667dfe8d00000848 Role of IGFBP2/PTPRB in osteoblast differentitiation (Human) NCBITaxon:9606 gomodel:667dfe8d00000848/667dfe8d00000849 GO:0141069 receptor ligand inhibitor activity GO:0001649 osteoblast differentiation GO:0005576 extracellular region false UniProtKB:P23467 PTPRB Hsap 667dfe8d00000848 Role of IGFBP2/PTPRB in osteoblast differentitiation (Human) NCBITaxon:9606 gomodel:667dfe8d00000848/667dfe8d00000856 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity GO:0001649 osteoblast differentiation GO:0005886 plasma membrane false UniProtKB:P60484 PTEN Hsap 667dfe8d00000848 Role of IGFBP2/PTPRB in osteoblast differentitiation (Human) NCBITaxon:9606 gomodel:667dfe8d00000848/667dfe8d00000864 GO:0030351 inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity GO:0045668 negative regulation of osteoblast differentiation GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 667dfe8d00000848 Role of IGFBP2/PTPRB in osteoblast differentitiation (Human) NCBITaxon:9606 gomodel:667dfe8d00000848/667dfe8d00000874 GO:0004672 protein kinase activity GO:0001649 osteoblast differentiation GO:0005737 cytoplasm false UniProtKB:Q96RI8 TAAR6 Hsap 6690711d00000012 "TAAR6-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000012/6690711d00000013 GO:0001594 trace-amine receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 6690711d00000012 "TAAR6-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000012/6690711d00000015 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 6690711d00000012 "TAAR6-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000012/6690711d00000017 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O14804 TAAR5 Hsap 6690711d00000055 "TAAR5-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000055/6690711d00000056 GO:1990081 trimethylamine receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 6690711d00000055 "TAAR5-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000055/6690711d00000058 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O60266 ADCY3 Hsap 6690711d00000055 "TAAR5-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by trimethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000055/6690711d00000060 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q96RI9 TAAR9 Hsap 6690711d00000101 "TAAR9-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000101/6690711d00000102 GO:0001594 trace-amine receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 6690711d00000101 "TAAR9-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000101/6690711d00000104 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 6690711d00000101 "TAAR9-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by beta-phenylethylamine (Human)." NCBITaxon:9606 gomodel:6690711d00000101/6690711d00000106 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8NGI8 OR5AN1 Hsap 6690711d00000142 "OR5AN1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by muscone (Human)." NCBITaxon:9606 gomodel:6690711d00000142/6690711d00000143 GO:0038022 G protein-coupled olfactory receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 6690711d00000142 "OR5AN1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by muscone (Human)." NCBITaxon:9606 gomodel:6690711d00000142/6690711d00000145 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 6690711d00000142 "OR5AN1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by muscone (Human)." NCBITaxon:9606 gomodel:6690711d00000142/6690711d00000147 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q05586 GRIN1 Hsap 6690711d00000596 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2A (human) NCBITaxon:9606 gomodel:6690711d00000596/6690711d00000597 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q12879 GRIN2A Hsap 6690711d00000596 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2A (human) NCBITaxon:9606 gomodel:6690711d00000596/6690711d00001397 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0017146 NMDA selective glutamate receptor complex 6690711d00000596 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2A (human) NCBITaxon:9606 gomodel:6690711d00000596/6690711d00001413 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:P49588 AARS1 Hsap 6690711d00001696 AARS1 mediates lactylation and inactivation of p53/TP53 (Human). NCBITaxon:9606 gomodel:6690711d00001696/6690711d00001697 GO:0141207 peptide lactyltransferase (ATP-dependent) activity GO:1901797 negative regulation of signal transduction by p53 class mediator false UniProtKB:P00338 LDHA Hsap 6690711d00001696 AARS1 mediates lactylation and inactivation of p53/TP53 (Human). NCBITaxon:9606 gomodel:6690711d00001696/6690711d00001704 GO:0004459 L-lactate dehydrogenase (NAD+) activity GO:0006089 lactate metabolic process true lactate_fermentation_and_bpg_shunt UniProtKB:P04637 TP53 Hsap 6690711d00001696 AARS1 mediates lactylation and inactivation of p53/TP53 (Human). NCBITaxon:9606 gomodel:6690711d00001696/6690711d00001712 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0005634 nucleus false UniProtKB:P04637 TP53 Hsap 6690711d00001696 AARS1 mediates lactylation and inactivation of p53/TP53 (Human). NCBITaxon:9606 gomodel:6690711d00001696/6690711d00001722 GO:0140693 molecular condensate scaffold activity GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0005634 nucleus false UniProtKB:P49588 AARS1 Hsap 6690711d00001733 Beta-alanine inhibits the lactyltransferase activity of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001733/6690711d00001734 GO:0141207 peptide lactyltransferase (ATP-dependent) activity GO:1901797 negative regulation of signal transduction by p53 class mediator false UniProtKB:P04637 TP53 Hsap 6690711d00001733 Beta-alanine inhibits the lactyltransferase activity of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001733/6690711d00001749 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0005634 nucleus false UniProtKB:P04637 TP53 Hsap 6690711d00001733 Beta-alanine inhibits the lactyltransferase activity of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001733/6690711d00001758 GO:0140693 molecular condensate scaffold activity GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0005634 nucleus false UniProtKB:P49588 AARS1 Hsap 6690711d00001771 AARS1 mediates lactylation of YAP1 and TEAD1, promoting activation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001771/6690711d00001772 GO:0141207 peptide lactyltransferase (ATP-dependent) activity GO:0035332 positive regulation of hippo signaling GO:0005634 nucleus false UniProtKB:P46937 YAP1 Hsap 6690711d00001771 AARS1 mediates lactylation of YAP1 and TEAD1, promoting activation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001771/6690711d00001783 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:P28347 TEAD1 Hsap 6690711d00001771 AARS1 mediates lactylation of YAP1 and TEAD1, promoting activation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001771/6690711d00001792 GO:0003700 DNA-binding transcription factor activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:Q96EB6 SIRT1 Hsap 6690711d00001806 SIRT1 mediates delactylation of YAP1 and TEAD1, promoting inactivation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001806/6690711d00001807 GO:0141208 NAD-dependent protein lysine delactylase activity GO:0035331 negative regulation of hippo signaling GO:0005634 nucleus false UniProtKB:P46937 YAP1 Hsap 6690711d00001806 SIRT1 mediates delactylation of YAP1 and TEAD1, promoting inactivation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001806/6690711d00001818 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:P28347 TEAD1 Hsap 6690711d00001806 SIRT1 mediates delactylation of YAP1 and TEAD1, promoting inactivation of Hippo signaling (Human). NCBITaxon:9606 gomodel:6690711d00001806/6690711d00001827 GO:0003700 DNA-binding transcription factor activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:O00629 KPNA4 Hsap 6690711d00001844 Nuclear import of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001844/6690711d00001852 GO:0140142 nucleocytoplasmic carrier activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q14974 KPNB1 Hsap 6690711d00001844 Nuclear import of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001844/6690711d00001861 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus false UniProtKB:P49588 AARS1 Hsap 6690711d00001844 Nuclear import of AARS1 (Human). NCBITaxon:9606 gomodel:6690711d00001844/6690711d00001868 GO:0141207 peptide lactyltransferase (ATP-dependent) activity GO:0035332 positive regulation of hippo signaling GO:0005634 nucleus false UniProtKB:O15031 PLXNB2 Hsap 6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). NCBITaxon:9606 gomodel:6690711d00002607/6690711d00002608 GO:0038023 signaling receptor activity GO:0006898 receptor-mediated endocytosis GO:0005886 plasma membrane false UniProtKB:P03950 ANG Hsap 6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). NCBITaxon:9606 gomodel:6690711d00002607/6690711d00002615 GO:0048018 receptor ligand activity GO:0007165 signal transduction GO:0005576 extracellular region false UniProtKB:P03950 ANG Hsap 6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). NCBITaxon:9606 gomodel:6690711d00002607/6690711d00002625 GO:0004549 tRNA-specific ribonuclease activity GO:0032055 negative regulation of translation in response to stress GO:0005737 cytoplasm false GO:0022625 cytosolic large ribosomal subunit 6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). NCBITaxon:9606 gomodel:6690711d00002607/6690711d00002632 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0005829 cytosol false GO:0022625 cytosolic large ribosomal subunit 6690711d00002607 ANG tRNA ribonuclease activity inhibits translation in response to stress (Human). NCBITaxon:9606 gomodel:6690711d00002607/6690711d00002639 GO:0008428 ribonuclease inhibitor activity GO:0033554 cellular response to stress GO:0005829 cytosol false UniProtKB:O15031 PLXNB2 Hsap 6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). NCBITaxon:9606 gomodel:6690711d00002652/6690711d00002653 GO:0038023 signaling receptor activity GO:0006898 receptor-mediated endocytosis GO:0005886 plasma membrane false UniProtKB:P03950 ANG Hsap 6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). NCBITaxon:9606 gomodel:6690711d00002652/6690711d00002660 GO:0048018 receptor ligand activity GO:0007165 signal transduction GO:0005576 extracellular region false UniProtKB:P03950 ANG Hsap 6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). NCBITaxon:9606 gomodel:6690711d00002652/6690711d00002670 GO:0004549 tRNA-specific ribonuclease activity GO:0032055 negative regulation of translation in response to stress GO:0005737 cytoplasm false GO:0022625 cytosolic large ribosomal subunit 6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). NCBITaxon:9606 gomodel:6690711d00002652/6690711d00002677 GO:0003735 structural constituent of ribosome GO:0002181 cytoplasmic translation GO:0005829 cytosol false UniProtKB:P13489 RNH1 Hsap 6690711d00002652 RNH1 inhibits the tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (Human). NCBITaxon:9606 gomodel:6690711d00002652/6690711d00002696 GO:0008428 ribonuclease inhibitor activity GO:0036416 tRNA stabilization GO:0005737 cytoplasm false UniProtKB:O15503 INSIG1 Hsap 66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000156/66a3e0bb00000189 GO:0140311 protein sequestering activity GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:P36956 SREBF1 Hsap 66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000156/66a3e0bb00000213 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005634 nucleus false UniProtKB:O43462 MBTPS2 Hsap 66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000156/66a3e0bb00000242 GO:0004222 metalloendopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:Q14974 KPNB1 Hsap 66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000156/66a3e0bb00000270 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q6TCH7 PAQR3 Hsap 66a3e0bb00000156 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF1-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000156/66a3e0bb00000381 GO:0043495 protein-membrane adaptor activity GO:0034067 protein localization to Golgi apparatus GO:0000139 Golgi membrane false UniProtKB:O15503 INSIG1 Hsap 66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000443/66a3e0bb00000444 GO:0140311 protein sequestering activity GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q12772 SREBF2 Hsap 66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000443/66a3e0bb00000456 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0045542 positive regulation of cholesterol biosynthetic process GO:0005634 nucleus false UniProtKB:O43462 MBTPS2 Hsap 66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000443/66a3e0bb00000466 GO:0004222 metalloendopeptidase activity GO:0051604 protein maturation GO:0000139 Golgi membrane false UniProtKB:Q14974 KPNB1 Hsap 66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000443/66a3e0bb00000475 GO:0061608 nuclear import signal receptor activity GO:0006607 NLS-bearing protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q6TCH7 PAQR3 Hsap 66a3e0bb00000443 Positive regulation of cholesterol biosynthesis by PAQR3 by anchoring SREBF2-SCAP complex to the Golgi. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000443/66a3e0bb00000490 GO:0043495 protein-membrane adaptor activity GO:0034067 protein localization to Golgi apparatus GO:0000139 Golgi membrane false UniProtKB:Q6TCH7 PAQR3 Hsap 66a3e0bb00000525 PAQR3 mediates PPARA polyubiquitination by HUWE1 in hepatocytes. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000525/66a3e0bb00000526 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005575 cellular_component false UniProtKB:Q7Z6Z7 HUWE1 Hsap 66a3e0bb00000525 PAQR3 mediates PPARA polyubiquitination by HUWE1 in hepatocytes. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000525/66a3e0bb00000539 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005575 cellular_component false UniProtKB:Q07869 PPARA Hsap 66a3e0bb00000525 PAQR3 mediates PPARA polyubiquitination by HUWE1 in hepatocytes. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000525/66a3e0bb00000551 GO:0004879 nuclear receptor activity GO:0035357 peroxisome proliferator activated receptor signaling pathway GO:0005634 nucleus false UniProtKB:Q6TCH7 PAQR3 Hsap 66a3e0bb00000922 PAQR3 mediates PPARG polyubiquitination by STUB1 in macrophages. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000922/66a3e0bb00000923 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005575 cellular_component false UniProtKB:Q9UNE7 STUB1 Hsap 66a3e0bb00000922 PAQR3 mediates PPARG polyubiquitination by STUB1 in macrophages. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000922/66a3e0bb00000930 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005575 cellular_component false UniProtKB:P37231 PPARG Hsap 66a3e0bb00000922 PAQR3 mediates PPARG polyubiquitination by STUB1 in macrophages. (Human) NCBITaxon:9606 gomodel:66a3e0bb00000922/66a3e0bb00000936 GO:0004879 nuclear receptor activity GO:0035357 peroxisome proliferator activated receptor signaling pathway GO:0005634 nucleus false UniProtKB:P08069 IGF1R Hsap 66a3e0bb00001036 IGF1-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001036/66a3e0bb00001038 GO:0005010 insulin-like growth factor receptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P05019 IGF1 Hsap 66a3e0bb00001036 IGF1-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001036/66a3e0bb00001045 GO:0008083 growth factor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P35568 IRS1 Hsap 66a3e0bb00001036 IGF1-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001036/66a3e0bb00001053 GO:0035591 signaling adaptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4H2 IRS2 Hsap 66a3e0bb00001036 IGF1-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001036/66a3e0bb00001066 GO:0035591 signaling adaptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P08069 IGF1R Hsap 66a3e0bb00001076 IGF2-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001076/66a3e0bb00001077 GO:0005010 insulin-like growth factor receptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P35568 IRS1 Hsap 66a3e0bb00001076 IGF2-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001076/66a3e0bb00001092 GO:0035591 signaling adaptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4H2 IRS2 Hsap 66a3e0bb00001076 IGF2-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001076/66a3e0bb00001105 GO:0035591 signaling adaptor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P01344 IGF2 Hsap 66a3e0bb00001076 IGF2-mediated signaling via IGF1R receptor (Human) NCBITaxon:9606 gomodel:66a3e0bb00001076/66a3e0bb00001115 GO:0008083 growth factor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q16602 CALCRL Hsap 66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001159/66a3e0bb00001160 GO:0001605 adrenomedullin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001159/66a3e0bb00001162 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001159/66a3e0bb00001164 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P35318 ADM Hsap 66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001159/66a3e0bb00001536 GO:0005179 hormone activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60895 RAMP2 Hsap 66a3e0bb00001159 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP2 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001159/66a3e0bb00001545 GO:0015026 coreceptor activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q16602 CALCRL Hsap 66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001555/66a3e0bb00001556 GO:0001605 adrenomedullin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001555/66a3e0bb00001558 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001555/66a3e0bb00001560 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P35318 ADM Hsap 66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001555/66a3e0bb00001588 GO:0005179 hormone activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60896 RAMP3 Hsap 66a3e0bb00001555 Signaling by Adrenomedullin mediated by ADM ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001555/66a3e0bb00001597 GO:0015026 coreceptor activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q16602 CALCRL Hsap 66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001633/66a3e0bb00001634 GO:0001605 adrenomedullin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001633/66a3e0bb00001636 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001633/66a3e0bb00001638 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q7Z4H4 ADM2 Hsap 66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001633/66a3e0bb00001665 GO:0005179 hormone activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60896 RAMP3 Hsap 66a3e0bb00001633 Signaling by Adrenomedullin mediated by ADM2 ligand activating CALCRL-RAMP3 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001633/66a3e0bb00001674 GO:0015026 coreceptor activity GO:1990410 adrenomedullin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q16602 CALCRL Hsap 66a3e0bb00001687 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001687/66a3e0bb00001688 GO:0001635 calcitonin gene-related peptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001687 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001687/66a3e0bb00001690 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001687 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001687/66a3e0bb00001692 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P06881-1 CALCA Hsap 66a3e0bb00001687 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001687/66a3e0bb00001719 GO:0005179 hormone activity GO:1990408 calcitonin gene-related peptide receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60894 RAMP1 Hsap 66a3e0bb00001687 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001687/66a3e0bb00001728 GO:0015026 coreceptor activity GO:1990408 calcitonin gene-related peptide receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q16602 CALCRL Hsap 66a3e0bb00001742 Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001742/66a3e0bb00001743 GO:0001635 calcitonin gene-related peptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001742 Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001742/66a3e0bb00001745 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001742 Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001742/66a3e0bb00001747 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P10092 CALCB Hsap 66a3e0bb00001742 Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001742/66a3e0bb00001774 GO:0005179 hormone activity GO:1990408 calcitonin gene-related peptide receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O60894 RAMP1 Hsap 66a3e0bb00001742 Signaling by Calcitonin/CGRP mediated by CALCB/CGRP2 ligand activating CALCRL-RAMP1 receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001742/66a3e0bb00001783 GO:0015026 coreceptor activity GO:1990408 calcitonin gene-related peptide receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P30988 CALCR Hsap 66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001796/66a3e0bb00001797 GO:0097643 amylin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001796/66a3e0bb00001799 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001796/66a3e0bb00001801 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P10997 IAPP Hsap 66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001796/66a3e0bb00001827 GO:0005179 hormone activity GO:0150059 amylin receptor 1 signaling pathway GO:0005576 extracellular region false UniProtKB:O60894 RAMP1 Hsap 66a3e0bb00001796 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001796/66a3e0bb00001836 GO:0015026 coreceptor activity GO:0150059 amylin receptor 1 signaling pathway GO:0005886 plasma membrane false UniProtKB:P30988 CALCR Hsap 66a3e0bb00001882 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001882/66a3e0bb00001883 GO:0097643 amylin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001882 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001882/66a3e0bb00001885 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001882 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001882/66a3e0bb00001887 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P10997 IAPP Hsap 66a3e0bb00001882 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001882/66a3e0bb00001913 GO:0005179 hormone activity GO:0150060 amylin receptor 2 signaling pathway GO:0005576 extracellular region false UniProtKB:O60895 RAMP2 Hsap 66a3e0bb00001882 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001882/66a3e0bb00001921 GO:0015026 coreceptor activity GO:0150060 amylin receptor 2 signaling pathway GO:0005886 plasma membrane false UniProtKB:P30988 CALCR Hsap 66a3e0bb00001935 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001935/66a3e0bb00001936 GO:0097643 amylin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66a3e0bb00001935 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001935/66a3e0bb00001938 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66a3e0bb00001935 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001935/66a3e0bb00001940 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P10997 IAPP Hsap 66a3e0bb00001935 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001935/66a3e0bb00001966 GO:0005179 hormone activity GO:0150061 amylin receptor 3 signaling pathway GO:0005576 extracellular region false UniProtKB:O60896 RAMP3 Hsap 66a3e0bb00001935 Signaling by Amylin mediated by IAPP ligand activating CALCR-RAMP3 (AMYR3) receptor complex (Human) NCBITaxon:9606 gomodel:66a3e0bb00001935/66a3e0bb00001974 GO:0015026 coreceptor activity GO:0150061 amylin receptor 3 signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6GPH6 ITPRIPL1 Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002105 GO:0048018 receptor ligand activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002112 GO:0004888 transmembrane signaling receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042101 T cell receptor complex 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002124 GO:0004888 transmembrane signaling receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002145 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P16333 NCK1 Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002157 GO:0140311 protein sequestering activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P43403 ZAP70 Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002177 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O43561 LAT Hsap 66a3e0bb00002104 ITPRIPL1 is a ligand of CD3E that negatively regulates TCR signaling pathway. (Human) NCBITaxon:9606 gomodel:66a3e0bb00002104/66a3e0bb00002189 GO:0035591 signaling adaptor activity GO:0043410 positive regulation of MAPK cascade GO:0005886 plasma membrane false UniProtKB:A1Z0Q5 gD NCBITaxon:10306 66a3e0bb00002740 TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human). NCBITaxon:9606 gomodel:66a3e0bb00002740/66a3e0bb00002741 GO:0048018 receptor ligand activity GO:0046718 symbiont entry into host cell GO:0055036 virion membrane false UniProtKB:Q15223 NECTIN1 Hsap 66a3e0bb00002740 TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human). NCBITaxon:9606 gomodel:66a3e0bb00002740/66a3e0bb00002748 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0005886 plasma membrane false UniProtKB:Q8IYR6 TMEFF1 Hsap 66a3e0bb00002740 TMEFF1 restricts herpes simplex virus 1 (HHV-1) infection in the brain by blocking the association between NECTIN1 and the viral envelope glycoprotein D (Human). NCBITaxon:9606 gomodel:66a3e0bb00002740/66a3e0bb00002756 GO:0141069 receptor ligand inhibitor activity GO:0046597 host-mediated suppression of symbiont invasion GO:0005886 plasma membrane false UniProtKB:P35579 MYH9 Hsap 66a3e0bb00002776 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002776/66a3e0bb00002777 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0009986 cell surface false UniProtKB:P06436 gB NCBITaxon:10304 66a3e0bb00002776 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002776/66a3e0bb00002784 GO:0048018 receptor ligand activity GO:0046718 symbiont entry into host cell GO:0055036 virion membrane false UniProtKB:Q8IYR6 TMEFF1 Hsap 66a3e0bb00002776 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH9 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002776/66a3e0bb00002820 GO:0141069 receptor ligand inhibitor activity GO:0046597 host-mediated suppression of symbiont invasion GO:0005886 plasma membrane false UniProtKB:P35580 MYH10 Hsap 66a3e0bb00002793 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002793/66a3e0bb00002794 GO:0001618 virus receptor activity GO:0046718 symbiont entry into host cell GO:0009986 cell surface false UniProtKB:P06436 gB NCBITaxon:10304 66a3e0bb00002793 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002793/66a3e0bb00002801 GO:0048018 receptor ligand activity GO:0046718 symbiont entry into host cell GO:0055036 virion membrane false UniProtKB:Q8IYR6 TMEFF1 Hsap 66a3e0bb00002793 TMEFF1 restricts herpes simplex virus 1 (HHV-1) in the brain by blocking the association between MYH10 and the viral envelope glycoprotein B (Human). NCBITaxon:9606 gomodel:66a3e0bb00002793/66a3e0bb00002810 GO:0141069 receptor ligand inhibitor activity GO:0046597 host-mediated suppression of symbiont invasion GO:0005886 plasma membrane false UniProtKB:P40238 MPL Hsap 66a3e0bb00002890 Thrombopoeitin-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:66a3e0bb00002890/66a3e0bb00002891 GO:0038164 thrombopoietin receptor activity GO:0038163 thrombopoietin-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P40225 THPO Hsap 66a3e0bb00002890 Thrombopoeitin-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:66a3e0bb00002890/66a3e0bb00002899 GO:0005125 cytokine activity GO:0038163 thrombopoietin-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:O60674 JAK2 Hsap 66a3e0bb00002890 Thrombopoeitin-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:66a3e0bb00002890/66a3e0bb00002919 GO:0004713 protein tyrosine kinase activity GO:0038163 thrombopoietin-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P42229 STAT5A Hsap 66a3e0bb00002890 Thrombopoeitin-mediated signaling pathway (Human) NCBITaxon:9606 gomodel:66a3e0bb00002890/66a3e0bb00002929 GO:0003700 DNA-binding transcription factor activity GO:0038163 thrombopoietin-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P35613 BSG Hsap 66b5638000000025 BSGT/GLUT1-mediated cone survival via NXNL1 ligand (Human) NCBITaxon:9606 gomodel:66b5638000000025/66b5638000000026 GO:0038023 signaling receptor activity GO:0045494 photoreceptor cell maintenance GO:0005886 plasma membrane false UniProtKB:Q96CM4 NXNL1 Hsap 66b5638000000025 BSGT/GLUT1-mediated cone survival via NXNL1 ligand (Human) NCBITaxon:9606 gomodel:66b5638000000025/66b5638000000033 GO:0048018 receptor ligand activity GO:0045494 photoreceptor cell maintenance false UniProtKB:P11166 SLC2A1 Hsap 66b5638000000025 BSGT/GLUT1-mediated cone survival via NXNL1 ligand (Human) NCBITaxon:9606 gomodel:66b5638000000025/66b5638000000043 GO:0055056 D-glucose transmembrane transporter activity GO:0045494 photoreceptor cell maintenance GO:0005886 plasma membrane false UniProtKB:Q15762 CD226 Hsap 66b5638000000102 PVR-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000000102/66b5638000000103 GO:0038023 signaling receptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P15151 PVR Hsap 66b5638000000102 PVR-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000000102/66b5638000000388 GO:0048018 receptor ligand activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 66b5638000000102 PVR-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000000102/66b5638000001269 GO:0030674 protein-macromolecule adaptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P15498 VAV1 Hsap 66b5638000000102 PVR-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000000102/66b5638000001281 GO:0005085 guanyl-nucleotide exchange factor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P50895 BCAM Hsap 66b5638000000321 BCAM-LAMA5 pair role in cell adhesion (Human) NCBITaxon:9606 gomodel:66b5638000000321/66b5638000000322 GO:0005055 laminin receptor activity GO:0007155 cell adhesion GO:0005886 plasma membrane false UniProtKB:O60674 JAK2 Hsap 66b5638000000321 BCAM-LAMA5 pair role in cell adhesion (Human) NCBITaxon:9606 gomodel:66b5638000000321/66b5638000000329 GO:0004713 protein tyrosine kinase activity GO:0007155 cell adhesion GO:0005737 cytoplasm false UniProtKB:O15230 LAMA5 Hsap 66b5638000000321 BCAM-LAMA5 pair role in cell adhesion (Human) NCBITaxon:9606 gomodel:66b5638000000321/66b5638000000341 GO:0048018 receptor ligand activity GO:0007155 cell adhesion GO:0005576 extracellular region false UniProtKB:P51114 FXR1 Hsap 66b5638000000353 FXR1 forms mRNP networks that act as signaling scaffold for actomyosin remodeling (Human) NCBITaxon:9606 gomodel:66b5638000000353/66b5638000000358 GO:0140693 molecular condensate scaffold activity GO:0140694 membraneless organelle assembly GO:0005737 cytoplasm false UniProtKB:O75116 ROCK2 Hsap 66b5638000000353 FXR1 forms mRNP networks that act as signaling scaffold for actomyosin remodeling (Human) NCBITaxon:9606 gomodel:66b5638000000353/66b5638000000363 GO:0072518 Rho-dependent protein serine/threonine kinase activity GO:0007266 Rho protein signal transduction GO:0005737 cytoplasm false UniProtKB:P24844 MYL9 Hsap 66b5638000000353 FXR1 forms mRNP networks that act as signaling scaffold for actomyosin remodeling (Human) NCBITaxon:9606 gomodel:66b5638000000353/66b5638000000393 GO:0005200 structural constituent of cytoskeleton GO:0043149 stress fiber assembly GO:0001725 stress fiber false UniProtKB:P05198 EIF2S1 Hsap 66b5638000000624 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human). NCBITaxon:9606 gomodel:66b5638000000624/66b5638000000674 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 66b5638000000624 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human). NCBITaxon:9606 gomodel:66b5638000000624/66b5638000000685 GO:0003700 DNA-binding transcription factor activity GO:0036499 PERK-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 66b5638000000624 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human). NCBITaxon:9606 gomodel:66b5638000000624/66b5638000000696 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000000624 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response (Human). NCBITaxon:9606 gomodel:66b5638000000624/66b5638000000724 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0036499 PERK-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:P05198 EIF2S1 Hsap 66b5638000000739 Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000739/66b5638000000740 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 66b5638000000739 Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000739/66b5638000000747 GO:0003700 DNA-binding transcription factor activity GO:0036499 PERK-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 66b5638000000739 Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000739/66b5638000000758 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000000739 Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000739/66b5638000000783 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0036499 PERK-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:P11021 HSPA5 Hsap 66b5638000000739 Inhibition of the PERK-mediated unfolded protein response by HSPA5/BiP in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000739/66b5638000000798 GO:0030291 protein serine/threonine kinase inhibitor activity GO:1903898 negative regulation of PERK-mediated unfolded protein response GO:0005829 cytosol false UniProtKB:Q14145 KEAP1 Hsap 66b5638000000808 Ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000808/66b5638000000809 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q16236 NFE2L2 Hsap 66b5638000000808 Ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000808/66b5638000000818 GO:0003700 DNA-binding transcription factor activity GO:0006979 response to oxidative stress GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 66b5638000000808 Ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000808/66b5638000000825 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 66b5638000000808 Ubiquitination and degradation of NFE2L2/NRF2 by KEAP1 in absence of stress (Human). NCBITaxon:9606 gomodel:66b5638000000808/66b5638000000836 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q14145 KEAP1 Hsap 66b5638000000873 EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human). NCBITaxon:9606 gomodel:66b5638000000873/66b5638000000874 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q16236 NFE2L2 Hsap 66b5638000000873 EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human). NCBITaxon:9606 gomodel:66b5638000000873/66b5638000000883 GO:0003700 DNA-binding transcription factor activity GO:0006979 response to oxidative stress GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 66b5638000000873 EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human). NCBITaxon:9606 gomodel:66b5638000000873/66b5638000000890 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000000873 EIF2AK3/PERK phosphorylates NFE2L2/NRF2 in response to unfolded protein response, preventing the ubiquitination of NFE2L2/NRF2 by KEAP1 (Human). NCBITaxon:9606 gomodel:66b5638000000873/66b5638000000909 GO:0004674 protein serine/threonine kinase activity GO:0036499 PERK-mediated unfolded protein response false UniProtKB:Q15762 CD226 Hsap 66b5638000001291 NECTIN2-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001291/66b5638000001292 GO:0038023 signaling receptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:Q92692 NECTIN2 Hsap 66b5638000001291 NECTIN2-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001291/66b5638000001299 GO:0048018 receptor ligand activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 66b5638000001291 NECTIN2-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001291/66b5638000001307 GO:0030674 protein-macromolecule adaptor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P15498 VAV1 Hsap 66b5638000001291 NECTIN2-CD226 mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001291/66b5638000001319 GO:0005085 guanyl-nucleotide exchange factor activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001329 ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001329/66b5638000001330 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 66b5638000001329 ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001329/66b5638000001337 GO:0003700 DNA-binding transcription factor activity GO:0036499 PERK-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001329 ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001329/66b5638000001348 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000001329 ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001329/66b5638000001373 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0036499 PERK-mediated unfolded protein response GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site false UniProtKB:Q9NVI7 ATAD3A Hsap 66b5638000001329 ATAD3A inhibits the PERK-mediated unfolded protein response in mitochondria by inhibiting EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001329/66b5638000001391 GO:0030291 protein serine/threonine kinase inhibitor activity GO:1903898 negative regulation of PERK-mediated unfolded protein response GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). NCBITaxon:9606 gomodel:66b5638000001589/66b5638000001590 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). NCBITaxon:9606 gomodel:66b5638000001589/66b5638000001597 GO:0003700 DNA-binding transcription factor activity GO:0036499 PERK-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). NCBITaxon:9606 gomodel:66b5638000001589/66b5638000001608 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). NCBITaxon:9606 gomodel:66b5638000001589/66b5638000001633 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0036499 PERK-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:O14548 COX7A2L Hsap 66b5638000001589 Activation of the integrated stress response via activation of EIF2AK3/PERK in response to unfolded protein response promotes expression of COX7A2L/SCAF1, increasing formation of respiratory chain supercomplexes (Human). NCBITaxon:9606 gomodel:66b5638000001589/66b5638000001650 GO:0030674 protein-macromolecule adaptor activity GO:0097250 mitochondrial respirasome assembly GO:0005743 mitochondrial inner membrane false UniProtKB:P30988 CALCR Hsap 66b5638000001665 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66b5638000001665/66b5638000001666 GO:0097642 calcitonin family receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66b5638000001665 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66b5638000001665/66b5638000001668 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66b5638000001665 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66b5638000001665/66b5638000001670 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01258 CALCA Hsap 66b5638000001665 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66b5638000001665/66b5638000001694 GO:0005179 hormone activity GO:0150060 amylin receptor 2 signaling pathway GO:0005576 extracellular region false UniProtKB:O60895 RAMP2 Hsap 66b5638000001665 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR-RAMP2 (AMYR2) receptor complex (Human) NCBITaxon:9606 gomodel:66b5638000001665/66b5638000001702 GO:0015026 coreceptor activity GO:0150060 amylin receptor 2 signaling pathway GO:0005886 plasma membrane false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001719 AKT1 inhibits EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001719/66b5638000001720 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:P18848 ATF4 Hsap 66b5638000001719 AKT1 inhibits EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001719/66b5638000001727 GO:0003700 DNA-binding transcription factor activity GO:0036499 PERK-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:P05198 EIF2S1 Hsap 66b5638000001719 AKT1 inhibits EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001719/66b5638000001737 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q9NZJ5 EIF2AK3 Hsap 66b5638000001719 AKT1 inhibits EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001719/66b5638000001749 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0036499 PERK-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:P31749 AKT1 Hsap 66b5638000001719 AKT1 inhibits EIF2AK3/PERK (Human). NCBITaxon:9606 gomodel:66b5638000001719/66b5638000001764 GO:0004674 protein serine/threonine kinase activity GO:1903898 negative regulation of PERK-mediated unfolded protein response false UniProtKB:P30988 CALCR Hsap 66b5638000001772 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001772/66b5638000001773 GO:0004948 calcitonin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66b5638000001772 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001772/66b5638000001775 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66b5638000001772 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001772/66b5638000001777 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01258 CALCA Hsap 66b5638000001772 Signaling by Calcitonin mediated by CALCA/CT ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001772/66b5638000001801 GO:0005179 hormone activity GO:0097646 calcitonin family receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P30988 CALCR Hsap 66b5638000001825 Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001825/66b5638000001826 GO:0097643 amylin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66b5638000001825 Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001825/66b5638000001828 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66b5638000001825 Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001825/66b5638000001830 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P10997 IAPP Hsap 66b5638000001825 Signaling by Amylin mediated by IAPP ligand activating CALCR receptor (Human) NCBITaxon:9606 gomodel:66b5638000001825/66b5638000001856 GO:0005179 hormone activity GO:0097647 amylin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q495A1 TIGIT Hsap 66b5638000001968 PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001968/66b5638000001986 GO:0038023 signaling receptor activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P15151 PVR Hsap 66b5638000001968 PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001968/66b5638000001993 GO:0048018 receptor ligand activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 66b5638000001968 PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001968/66b5638000002003 GO:0030674 protein-macromolecule adaptor activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:Q92835 INPP5D Hsap 66b5638000001968 PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001968/66b5638000002013 GO:0004445 inositol-polyphosphate 5-phosphatase activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P42338 PIK3CB Hsap 66b5638000001968 PVR-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000001968/66b5638000002023 GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:Q495A1 TIGIT Hsap 66b5638000002031 NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000002031/66b5638000002032 GO:0038023 signaling receptor activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 66b5638000002031 NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000002031/66b5638000002049 GO:0030674 protein-macromolecule adaptor activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:Q92835 INPP5D Hsap 66b5638000002031 NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000002031/66b5638000002059 GO:0004445 inositol-polyphosphate 5-phosphatase activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:P42338 PIK3CB Hsap 66b5638000002031 NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000002031/66b5638000002069 GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0042267 natural killer cell mediated cytotoxicity GO:0005737 cytoplasm false UniProtKB:Q92692 NECTIN2 Hsap 66b5638000002031 NECTIN2-TIGIT pair inhibits NK cell mediated cytotoxicity (Human) NCBITaxon:9606 gomodel:66b5638000002031/66b5638000002077 GO:0048018 receptor ligand activity GO:0045953 negative regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002273/66b5638000002275 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:P50148 GNAQ Hsap 66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002273/66b5638000002276 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P05129 PRKCG Hsap 66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002273/66b5638000002312 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:Q13255 GRM1 Hsap 66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002273/66b5638000002422 GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0098839 postsynaptic density membrane false UniProtKB:O43424 GRID2 Hsap 66b5638000002273 GRIM1 activates GRID2 via GNAQ in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002273/66b5638000002438 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:0099538 synaptic signaling via neuropeptide GO:0098839 postsynaptic density membrane false UniProtKB:Q01970 PLCB3 Hsap 66b5638000002450 GRIM1 GPCR signaling in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002450/66b5638000002451 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:P50148 GNAQ Hsap 66b5638000002450 GRIM1 GPCR signaling in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002450/66b5638000002452 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:P05129 PRKCG Hsap 66b5638000002450 GRIM1 GPCR signaling in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002450/66b5638000002471 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:Q13255 GRM1 Hsap 66b5638000002450 GRIM1 GPCR signaling in Purkinje cells (Human). NCBITaxon:9606 gomodel:66b5638000002450/66b5638000002482 GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0098839 postsynaptic density membrane false UniProtKB:O75144 ICOSLG Hsap 66b5638000002510 ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human) NCBITaxon:9606 gomodel:66b5638000002510/66b5638000002511 GO:0048018 receptor ligand activity GO:0061470 T follicular helper cell differentiation GO:0005886 plasma membrane false UniProtKB:Q9Y6W8 ICOS Hsap 66b5638000002510 ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human) NCBITaxon:9606 gomodel:66b5638000002510/66b5638000002518 GO:0038023 signaling receptor activity GO:0061470 T follicular helper cell differentiation GO:0005886 plasma membrane false UniProtKB:Q9UHD2 TBK1 Hsap 66b5638000002510 ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human) NCBITaxon:9606 gomodel:66b5638000002510/66b5638000002588 GO:0004674 protein serine/threonine kinase activity GO:0061470 T follicular helper cell differentiation GO:0005737 cytoplasm false UniProtKB:P27986 PIK3R1 Hsap 66b5638000002510 ICOSLG-ICOS pair activates T follicular helper cell differentiation (Human) NCBITaxon:9606 gomodel:66b5638000002510/66b5638000002690 GO:0035014 phosphatidylinositol 3-kinase regulator activity GO:0061470 T follicular helper cell differentiation GO:0005737 cytoplasm false UniProtKB:Q01970 PLCB3 Hsap 66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). NCBITaxon:9606 gomodel:66b5638000002630/66b5638000002631 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:P50148 GNAQ Hsap 66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). NCBITaxon:9606 gomodel:66b5638000002630/66b5638000002632 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P05129 PRKCG Hsap 66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). NCBITaxon:9606 gomodel:66b5638000002630/66b5638000002651 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0099524 postsynaptic cytosol false UniProtKB:Q9ULK0 GRID1 Hsap 66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). NCBITaxon:9606 gomodel:66b5638000002630/66b5638000002662 GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0098839 postsynaptic density membrane false UniProtKB:Q9ULK0 GRID1 Hsap 66b5638000002630 GRIM1 activates GRID1 via GNAQ in dopamine neurons (Human). NCBITaxon:9606 gomodel:66b5638000002630/66b5638000002678 GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential GO:0099538 synaptic signaling via neuropeptide GO:0098839 postsynaptic density membrane false UniProtKB:Q14627 IL13RA2 Hsap 66b5638000002701 IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) NCBITaxon:9606 gomodel:66b5638000002701/66b5638000002702 GO:0004896 cytokine receptor activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P35225 IL13 Hsap 66b5638000002701 IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) NCBITaxon:9606 gomodel:66b5638000002701/66b5638000002709 GO:0005125 cytokine activity GO:0035772 interleukin-13-mediated signaling pathway GO:0005576 extracellular region false GO:0035976 transcription factor AP-1 complex 66b5638000002701 IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) NCBITaxon:9606 gomodel:66b5638000002701/66b5638000002727 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0032905 transforming growth factor beta1 production GO:0005634 nucleus false UniProtKB:P01137 TGFB1 Hsap 66b5638000002701 IL13RA2-mediated alternative IL13 pathway leading to TGFB1 production (Human) NCBITaxon:9606 gomodel:66b5638000002701/66b5638000002744 GO:0005125 cytokine activity GO:0007179 transforming growth factor beta receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q86SQ9 DHDDS Hsap 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000081 GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity GO:0043048 dolichyl monophosphate biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q8N5I4 DHRSX Hsap 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000088 GO:0160196 polyprenol dehydrogenase (NAD+) activity GO:0043048 dolichyl monophosphate biosynthetic process GO:0005811 lipid droplet false UniProtKB:Q8N5I4 DHRSX Hsap 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000095 GO:0160197 dolichal reductase (NADPH) activity GO:0043048 dolichyl monophosphate biosynthetic process GO:0005811 lipid droplet false UniProtKB:Q9H8P0 SRD5A3 Hsap 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000102 GO:0160198 polyprenal reductase activity GO:0043048 dolichyl monophosphate biosynthetic process GO:0005789 endoplasmic reticulum membrane true dolichol_phosphate_sugar_donor_supply UniProtKB:Q9UPQ8 DOLK Hsap 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000114 GO:0004168 dolichol kinase activity GO:0043048 dolichyl monophosphate biosynthetic process GO:0005789 endoplasmic reticulum membrane true dolichol_phosphate_sugar_donor_supply CHEBI:36080 protein 66c7d41500000080 Dolichol biosynthetic process (Human). NCBITaxon:9606 gomodel:66c7d41500000080/66c7d41500000131 GO:0003824 catalytic activity GO:0043048 dolichyl monophosphate biosynthetic process false UniProtKB:P30988 CALCR Hsap 66c7d41500000163 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66c7d41500000163/66c7d41500000164 GO:0001635 calcitonin gene-related peptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66c7d41500000163 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66c7d41500000163/66c7d41500000166 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66c7d41500000163 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66c7d41500000163/66c7d41500000168 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P06881-1 CALCA Hsap 66c7d41500000163 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66c7d41500000163/66c7d41500000194 GO:0005179 hormone activity GO:0150059 amylin receptor 1 signaling pathway GO:0005576 extracellular region false UniProtKB:O60894 RAMP1 Hsap 66c7d41500000163 Signaling by Calcitonin/CGRP mediated by CALCA/CGRP1 ligand activating CALCR-RAMP1 (AMYR1) receptor complex (Human) NCBITaxon:9606 gomodel:66c7d41500000163/66c7d41500000202 GO:0015026 coreceptor activity GO:0150059 amylin receptor 1 signaling pathway GO:0005886 plasma membrane false UniProtKB:A7E2V4 ZSWIM8 Hsap 66c7d41500000427 Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) NCBITaxon:9606 gomodel:66c7d41500000427/66c7d41500000466 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005829 cytosol false UniProtKB:Q32ZE1 Q32ZE1 ZIKV 66c7d41500000427 Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) NCBITaxon:9606 gomodel:66c7d41500000427/66c7d41500000500 GO:0030674 protein-macromolecule adaptor activity GO:0140886 symbiont-mediated suppression of host interferon-mediated signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:P52630 STAT2 Hsap 66c7d41500000427 Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) NCBITaxon:9606 gomodel:66c7d41500000427/66c7d41500000515 GO:0003700 DNA-binding transcription factor activity GO:0060337 type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:Q13618 CUL3 Hsap 66c7d41500000427 Zika virus NS5 inhibition of STAT2 signaling via ZSWIM8 (Human-Zika virus) NCBITaxon:9606 gomodel:66c7d41500000427/66c7d41500000524 GO:0160072 ubiquitin ligase complex scaffold activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q05586 GRIN1 Hsap 66c7d41500000672 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2B (Human) NCBITaxon:9606 gomodel:66c7d41500000672/66c7d41500000677 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q13224 GRIN2B Hsap 66c7d41500000672 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2B (Human) NCBITaxon:9606 gomodel:66c7d41500000672/66c7d41500000686 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0017146 NMDA selective glutamate receptor complex 66c7d41500000672 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2B (Human) NCBITaxon:9606 gomodel:66c7d41500000672/66c7d41500000700 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q5QGZ9 CLEC12A Hsap 66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation (Human). NCBITaxon:9606 gomodel:66c7d41500000715/66c7d41500000716 GO:0004888 transmembrane signaling receptor activity GO:1902564 negative regulation of neutrophil activation GO:0005886 plasma membrane false UniProtKB:P12931 SRC Hsap 66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation (Human). NCBITaxon:9606 gomodel:66c7d41500000715/66c7d41500000723 GO:0004713 protein tyrosine kinase activity GO:1902564 negative regulation of neutrophil activation false UniProtKB:P29350 PTPN6 Hsap 66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation (Human). NCBITaxon:9606 gomodel:66c7d41500000715/66c7d41500000731 GO:0004725 protein tyrosine phosphatase activity GO:1902564 negative regulation of neutrophil activation false UniProtKB:Q06124 PTPN11 Hsap 66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation (Human). NCBITaxon:9606 gomodel:66c7d41500000715/66c7d41500000736 GO:0004725 protein tyrosine phosphatase activity GO:1902564 negative regulation of neutrophil activation false UniProtKB:P43405 SYK Hsap 66c7d41500000715 CLEC12A acts as an inhibitor of neutrophil activation (Human). NCBITaxon:9606 gomodel:66c7d41500000715/66c7d41500000744 GO:0004713 protein tyrosine kinase activity GO:0002283 neutrophil activation involved in immune response false UniProtKB:Q5T4S7 UBR4 Hsap 66c7d41500000754 Dengue virus NS5 inhibition of STAT2 signaling via UBR4 (Human) NCBITaxon:9606 gomodel:66c7d41500000754/66c7d41500000755 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005829 cytosol false UniProtKB:P29990 P29990 NCBITaxon:31634 66c7d41500000754 Dengue virus NS5 inhibition of STAT2 signaling via UBR4 (Human) NCBITaxon:9606 gomodel:66c7d41500000754/66c7d41500000764 GO:0030674 protein-macromolecule adaptor activity GO:0140886 symbiont-mediated suppression of host interferon-mediated signaling pathway GO:0030430 host cell cytoplasm false UniProtKB:P52630 STAT2 Hsap 66c7d41500000754 Dengue virus NS5 inhibition of STAT2 signaling via UBR4 (Human) NCBITaxon:9606 gomodel:66c7d41500000754/66c7d41500000775 GO:0003700 DNA-binding transcription factor activity GO:0060337 type I interferon-mediated signaling pathway GO:0005634 nucleus false UniProtKB:Q05586 GRIN1 Hsap 66c7d41500001120 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2C (Human) NCBITaxon:9606 gomodel:66c7d41500001120/66c7d41500001125 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q14957 GRIN2C Hsap 66c7d41500001120 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2C (Human) NCBITaxon:9606 gomodel:66c7d41500001120/66c7d41500001132 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0017146 NMDA selective glutamate receptor complex 66c7d41500001120 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2C (Human) NCBITaxon:9606 gomodel:66c7d41500001120/66c7d41500001144 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q05586 GRIN1 Hsap 66c7d41500001953 glycine-gated cation channel activity involving GRIN1 and GRIN3A (Human) NCBITaxon:9606 gomodel:66c7d41500001953/66c7d41500001958 GO:0160212 glycine-gated cation channel activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q8TCU5 GRIN3A Hsap 66c7d41500001953 glycine-gated cation channel activity involving GRIN1 and GRIN3A (Human) NCBITaxon:9606 gomodel:66c7d41500001953/66c7d41500001964 GO:0160212 glycine-gated cation channel activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0098878 neurotransmitter receptor complex 66c7d41500001953 glycine-gated cation channel activity involving GRIN1 and GRIN3A (Human) NCBITaxon:9606 gomodel:66c7d41500001953/66c7d41500001975 GO:0022824 transmitter-gated monoatomic ion channel activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q86WV6 STING1 Hsap 66c7d41500002413 DDX41 activation of the cGAS-STING signaling (Human) NCBITaxon:9606 gomodel:66c7d41500002413/66c7d41500002414 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 66c7d41500002413 DDX41 activation of the cGAS-STING signaling (Human) NCBITaxon:9606 gomodel:66c7d41500002413/66c7d41500002432 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q9UJV9 DDX41 Hsap 66c7d41500002413 DDX41 activation of the cGAS-STING signaling (Human) NCBITaxon:9606 gomodel:66c7d41500002413/66c7d41500002489 GO:0003724 RNA helicase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q06187 BTK Hsap 66c7d41500002413 DDX41 activation of the cGAS-STING signaling (Human) NCBITaxon:9606 gomodel:66c7d41500002413/66c7d41500002499 GO:0004713 protein tyrosine kinase activity GO:0141111 positive regulation of cGAS/STING signaling pathway GO:0005737 cytoplasm false UniProtKB:P49792 RANBP2 Hsap 66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm (Human) NCBITaxon:9606 gomodel:66c7d41500002513/66c7d41500002514 GO:0061665 SUMO ligase activity GO:0016925 protein sumoylation GO:0005634 nucleus false UniProtKB:O00148 DDX39A Hsap 66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm (Human) NCBITaxon:9606 gomodel:66c7d41500002513/66c7d41500002521 GO:0003723 RNA binding GO:0046832 negative regulation of RNA export from nucleus GO:0005634 nucleus false UniProtKB:Q7Z434 MAVS Hsap 66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm (Human) NCBITaxon:9606 gomodel:66c7d41500002513/66c7d41500002531 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm (Human) NCBITaxon:9606 gomodel:66c7d41500002513/66c7d41500002538 GO:0061630 ubiquitin protein ligase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q13114 TRAF3 Hsap 66c7d41500002513 DDX39A inhibition of immune related RNA export to the cytoplasm (Human) NCBITaxon:9606 gomodel:66c7d41500002513/66c7d41500002551 GO:0061630 ubiquitin protein ligase activity GO:0002224 toll-like receptor signaling pathway GO:0005768 endosome false UniProtKB:Q05586 GRIN1 Hsap 66c7d41500003371 glycine-gated cation channel activity involving GRIN1 and GRIN3B (Human) NCBITaxon:9606 gomodel:66c7d41500003371/66c7d41500003374 GO:0160212 glycine-gated cation channel activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:O60391 GRIN3B Hsap 66c7d41500003371 glycine-gated cation channel activity involving GRIN1 and GRIN3B (Human) NCBITaxon:9606 gomodel:66c7d41500003371/66c7d41500003380 GO:0160212 glycine-gated cation channel activity GO:0098655 monoatomic cation transmembrane transport GO:0042734 presynaptic membrane false GO:0098878 neurotransmitter receptor complex 66c7d41500003371 glycine-gated cation channel activity involving GRIN1 and GRIN3B (Human) NCBITaxon:9606 gomodel:66c7d41500003371/66c7d41500003391 GO:0022824 transmitter-gated monoatomic ion channel activity GO:0098655 monoatomic cation transmembrane transport GO:0042734 presynaptic membrane false UniProtKB:Q05586 GRIN1 Hsap 66c7d41500003458 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2D (Human) NCBITaxon:9606 gomodel:66c7d41500003458/66c7d41500003463 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:O15399 GRIN2D Hsap 66c7d41500003458 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2D (Human) NCBITaxon:9606 gomodel:66c7d41500003458/66c7d41500003469 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0017146 NMDA selective glutamate receptor complex 66c7d41500003458 NMDA glutamate receptor activity co-activated by glycine and involving GRIN1 and GRIN2D (Human) NCBITaxon:9606 gomodel:66c7d41500003458/66c7d41500003480 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q96BW5 PTER Hsap 66e382fb00000012 Taurine metabolic process (Human). NCBITaxon:9606 gomodel:66e382fb00000012/66e382fb00000013 GO:0141215 N-acetyltaurine hydrolase activity GO:0019530 taurine metabolic process GO:0005829 cytosol false UniProtKB:Q9Y600 CSAD Hsap 66e382fb00000012 Taurine metabolic process (Human). NCBITaxon:9606 gomodel:66e382fb00000012/66e382fb00000020 GO:0004782 sulfinoalanine decarboxylase activity GO:0042412 taurine biosynthetic process false UniProtKB:Q01740 FMO1 Hsap 66e382fb00000012 Taurine metabolic process (Human). NCBITaxon:9606 gomodel:66e382fb00000012/66e382fb00000026 GO:0047822 hypotaurine monooxygenase activity GO:0042412 taurine biosynthetic process false UniProtKB:Q16878 CDO1 Hsap 66e382fb00000012 Taurine metabolic process (Human). NCBITaxon:9606 gomodel:66e382fb00000012/66e382fb00000039 GO:0017172 cysteine dioxygenase activity GO:0042412 taurine biosynthetic process GO:0005829 cytosol false UniProtKB:Q05586 GRIN1 Hsap 66e382fb00000049 NMDA glutamate receptor activity co-activated by D-serine and involving GRIN1 and GRIN2A (Human) NCBITaxon:9606 gomodel:66e382fb00000049/66e382fb00000075 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:Q12879 GRIN2A Hsap 66e382fb00000049 NMDA glutamate receptor activity co-activated by D-serine and involving GRIN1 and GRIN2A (Human) NCBITaxon:9606 gomodel:66e382fb00000049/66e382fb00000083 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false GO:0017146 NMDA selective glutamate receptor complex 66e382fb00000049 NMDA glutamate receptor activity co-activated by D-serine and involving GRIN1 and GRIN2A (Human) NCBITaxon:9606 gomodel:66e382fb00000049/66e382fb00000094 GO:0004972 NMDA glutamate receptor activity GO:0098655 monoatomic cation transmembrane transport GO:0045211 postsynaptic membrane false UniProtKB:P32241 VIPR1 Hsap 66e382fb00000178 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000178/66e382fb00000179 GO:0004999 vasoactive intestinal polypeptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00000178 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000178/66e382fb00000181 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00000178 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000178/66e382fb00000183 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01282 VIP Hsap 66e382fb00000178 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000178/66e382fb00000209 GO:0005184 neuropeptide hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41587 VIPR2 Hsap 66e382fb00000254 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000254/66e382fb00000255 GO:0004999 vasoactive intestinal polypeptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00000254 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000254/66e382fb00000257 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00000254 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000254/66e382fb00000259 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01282 VIP Hsap 66e382fb00000254 Signaling by Vasoactive Intestinal Peptide/VIP mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000254/66e382fb00000281 GO:0005184 neuropeptide hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32241 VIPR1 Hsap 66e382fb00000408 Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000408/66e382fb00000409 GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00000408 Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000408/66e382fb00000411 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00000408 Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000408/66e382fb00000413 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P18509 ADCYAP1 Hsap 66e382fb00000408 Signaling by PACAP/ADCYAP1 mediated by VIPR1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000408/66e382fb00000435 GO:0005184 neuropeptide hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41587 VIPR2 Hsap 66e382fb00000449 Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000449/66e382fb00000450 GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00000449 Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000449/66e382fb00000452 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00000449 Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000449/66e382fb00000454 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P18509 ADCYAP1 Hsap 66e382fb00000449 Signaling by PACAP/ADCYAP1 mediated by VIPR2 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000449/66e382fb00000476 GO:0005184 neuropeptide hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q96PU5 NEDD4L Hsap 66e382fb00000490 NEDD4L regulates ENaC (Human) NCBITaxon:9606 gomodel:66e382fb00000490/66e382fb00000508 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0016324 apical plasma membrane false GO:0034706 sodium channel complex 66e382fb00000490 NEDD4L regulates ENaC (Human) NCBITaxon:9606 gomodel:66e382fb00000490/66e382fb00000524 GO:0005272 sodium channel activity GO:0098719 sodium ion import across plasma membrane GO:0016324 apical plasma membrane false UniProtKB:P41586 ADCYAP1R1 Hsap 66e382fb00000583 Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000583/66e382fb00000584 GO:0001634 pituitary adenylate cyclase-activating polypeptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00000583 Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000583/66e382fb00000586 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00000583 Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000583/66e382fb00000588 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P18509 ADCYAP1 Hsap 66e382fb00000583 Signaling by PACAP/ADCYAP1 mediated by PAC1R/ADCYAP1R1 receptor (Human) NCBITaxon:9606 gomodel:66e382fb00000583/66e382fb00000610 GO:0005184 neuropeptide hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P12645 BMP3 Hsap 66e382fb00001097 BMP3 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001097/66e382fb00001099 GO:0005125 cytokine activity GO:0030279 negative regulation of ossification GO:0005576 extracellular region false UniProtKB:Q13705 ACVR2B Hsap 66e382fb00001097 BMP3 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001097/66e382fb00001108 GO:0016362 activin receptor activity, type II GO:0030279 negative regulation of ossification GO:0005886 plasma membrane false UniProtKB:P36896 ACVR1B Hsap 66e382fb00001097 BMP3 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001097/66e382fb00001121 GO:0016361 activin receptor activity, type I GO:0030279 negative regulation of ossification GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 66e382fb00001097 BMP3 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001097/66e382fb00001132 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030279 negative regulation of ossification GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 66e382fb00001097 BMP3 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001097/66e382fb00001139 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030279 negative regulation of ossification GO:0005634 nucleus false UniProtKB:P36896 ACVR1B Hsap 66e382fb00001148 BMP3b/GDF10 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001148/66e382fb00001166 GO:0016361 activin receptor activity, type I GO:0030279 negative regulation of ossification GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 66e382fb00001148 BMP3b/GDF10 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001148/66e382fb00001177 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030279 negative regulation of ossification GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 66e382fb00001148 BMP3b/GDF10 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001148/66e382fb00001184 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0030279 negative regulation of ossification GO:0005634 nucleus false UniProtKB:P55107 GDF10 Hsap 66e382fb00001148 BMP3b/GDF10 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001148/66e382fb00001193 GO:0005125 cytokine activity GO:0030279 negative regulation of ossification GO:0005576 extracellular region false UniProtKB:P27037 ACVR2A Hsap 66e382fb00001148 BMP3b/GDF10 signaling leading to bone formation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00001148/66e382fb00001208 GO:0016361 activin receptor activity, type I GO:0030279 negative regulation of ossification GO:0005886 plasma membrane false UniProtKB:P12644 BMP4 Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001233 GO:0005125 cytokine activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:Q13873 BMPR2 Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001240 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:P36894 BMPR1A Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001247 GO:0005025 transforming growth factor beta receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001262 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q99717 SMAD5 Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001273 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 66e382fb00001232 BMP4 signaling pathway (Human) NCBITaxon:9606 gomodel:66e382fb00001232/66e382fb00001281 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:P22003 BMP5 Hsap 66e382fb00001388 BMP5 role in dendritic growth via SMAD1 (Human) NCBITaxon:9606 gomodel:66e382fb00001388/66e382fb00001389 GO:0005125 cytokine activity GO:1900006 positive regulation of dendrite development GO:0005576 extracellular region false UniProtKB:Q15797 SMAD1 Hsap 66e382fb00001388 BMP5 role in dendritic growth via SMAD1 (Human) NCBITaxon:9606 gomodel:66e382fb00001388/66e382fb00001396 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:1900006 positive regulation of dendrite development GO:0005634 nucleus false UniProtKB:P36894 BMPR1A Hsap 66e382fb00001388 BMP5 role in dendritic growth via SMAD1 (Human) NCBITaxon:9606 gomodel:66e382fb00001388/66e382fb00001403 GO:0005025 transforming growth factor beta receptor activity, type I GO:1900006 positive regulation of dendrite development GO:0005886 plasma membrane false UniProtKB:P42345 MTOR Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001413 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q9BPZ7 MAPKAP1 Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001422 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q6R327 RICTOR Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001432 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001442 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15530 PDPK1 Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001447 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q9BVC4 MLST8 Hsap 66e382fb00001412 mTORC2 signaling (Human). NCBITaxon:9606 gomodel:66e382fb00001412/66e382fb00001457 GO:0030674 protein-macromolecule adaptor activity GO:0038203 TORC2 signaling false UniProtKB:P42345 MTOR Hsap 66e382fb00001468 EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). NCBITaxon:9606 gomodel:66e382fb00001468/66e382fb00001469 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q6R327 RICTOR Hsap 66e382fb00001468 EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). NCBITaxon:9606 gomodel:66e382fb00001468/66e382fb00001488 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 66e382fb00001468 EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). NCBITaxon:9606 gomodel:66e382fb00001468/66e382fb00001498 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15530 PDPK1 Hsap 66e382fb00001468 EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). NCBITaxon:9606 gomodel:66e382fb00001468/66e382fb00001503 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q09472 EP300 Hsap 66e382fb00001468 EP300 activates the mTORC2 pathway by mediating acetylation of RICTOR (Human). NCBITaxon:9606 gomodel:66e382fb00001468/66e382fb00001523 GO:0061733 protein-lysine-acetyltransferase activity GO:1904515 positive regulation of TORC2 signaling false UniProtKB:P42345 MTOR Hsap 66e382fb00001531 GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66e382fb00001531/66e382fb00001532 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q6R327 RICTOR Hsap 66e382fb00001531 GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66e382fb00001531/66e382fb00001541 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 66e382fb00001531 GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66e382fb00001531/66e382fb00001551 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15530 PDPK1 Hsap 66e382fb00001531 GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66e382fb00001531/66e382fb00001556 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:P49841 GSK3B Hsap 66e382fb00001531 GSK3B inhibits the mTORC2 pathway by mediating phosphorylation of RICTOR in response to endoplasmic reticulum stress (Human). NCBITaxon:9606 gomodel:66e382fb00001531/66e382fb00001573 GO:0004674 protein serine/threonine kinase activity GO:1903940 negative regulation of TORC2 signaling false UniProtKB:P22004 BMP6 Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001607 GO:0005125 cytokine activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:Q13705 ACVR2B Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001696 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q04771 ACVR1 Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001707 GO:0016361 activin receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001713 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q99717 SMAD5 Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001719 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001724 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q4G0M1 ERFE Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001758 GO:0140313 molecular sequestering activity GO:0030514 negative regulation of BMP signaling pathway GO:0005576 extracellular region false UniProtKB:P81172 HAMP Hsap 66e382fb00001606 Hepcidin induction by BMP6 signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001606/66e382fb00001772 GO:0141108 transporter regulator activity GO:0006879 intracellular iron ion homeostasis GO:0005576 extracellular region false UniProtKB:Q13705 ACVR2B Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001794 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001808 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q99717 SMAD5 Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001814 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001819 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q4G0M1 ERFE Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001849 GO:0140313 molecular sequestering activity GO:0030514 negative regulation of BMP signaling pathway GO:0005576 extracellular region false UniProtKB:P81172 HAMP Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001859 GO:0141108 transporter regulator activity GO:0006879 intracellular iron ion homeostasis GO:0005576 extracellular region false GO:0032991 protein-containing complex 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001870 GO:0005125 cytokine activity GO:0030509 BMP signaling pathway GO:0005576 extracellular region false UniProtKB:P36894 BMPR1A Hsap 66e382fb00001786 Hepcidin induction by BMP2/BMP6 complex signaling (Human) NCBITaxon:9606 gomodel:66e382fb00001786/66e382fb00001885 GO:0005025 transforming growth factor beta receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:P42345 MTOR Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001914 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q9BPZ7 MAPKAP1 Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001923 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:Q6R327 RICTOR Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001933 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001943 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15530 PDPK1 Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001948 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:P23443 RPS6KB1 Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001968 GO:0004674 protein serine/threonine kinase activity GO:1903940 negative regulation of TORC2 signaling false UniProtKB:P23443 RPS6KB1 Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001980 GO:0004674 protein serine/threonine kinase activity GO:1903940 negative regulation of TORC2 signaling false UniProtKB:P42345 MTOR Hsap 66e382fb00001913 mTORC1 inhibits mTORC2 signaling via phosphorylation of RICTOR and MAPKAP1 by RPS6KB1 (Human). NCBITaxon:9606 gomodel:66e382fb00001913/66e382fb00001988 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling false UniProtKB:P42345 MTOR Hsap 66e382fb00001997 mTORC2 phosphorylates IMP1/IGF2BP1 to promote IGF2 production (Human). NCBITaxon:9606 gomodel:66e382fb00001997/66e382fb00001998 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling false UniProtKB:Q9NZI8 IGF2BP1 Hsap 66e382fb00001997 mTORC2 phosphorylates IMP1/IGF2BP1 to promote IGF2 production (Human). NCBITaxon:9606 gomodel:66e382fb00001997/66e382fb00002005 GO:0003730 mRNA 3'-UTR binding GO:2000767 positive regulation of cytoplasmic translation false UniProtKB:P01344 IGF2 Hsap 66e382fb00001997 mTORC2 phosphorylates IMP1/IGF2BP1 to promote IGF2 production (Human). NCBITaxon:9606 gomodel:66e382fb00001997/66e382fb00002023 GO:0008083 growth factor activity GO:0008284 positive regulation of cell population proliferation false UniProtKB:Q13873 BMPR2 Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002148 GO:0016362 activin receptor activity, type II GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q7Z5Y6 BMP8A Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002159 GO:0005125 cytokine activity GO:0030154 cell differentiation GO:0005576 extracellular region false UniProtKB:P36894 BMPR1A Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002169 GO:0005025 transforming growth factor beta receptor activity, type I GO:0030509 BMP signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002185 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:Q99717 SMAD5 Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002197 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:O15198 SMAD9 Hsap 66e382fb00002105 BMP8A role in spermatogenesis via SMAD1, SMAD5 and SMAD9 (Human) NCBITaxon:9606 gomodel:66e382fb00002105/66e382fb00002214 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0030509 BMP signaling pathway GO:0005634 nucleus false UniProtKB:P34820 BMP8B Hsap 66e382fb00002243 BMP8B role in adipocyte differentiation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00002243/671ae02600000609 GO:0005125 cytokine activity GO:0045596 negative regulation of cell differentiation GO:0005576 extracellular region false UniProtKB:P36896 ACVR1B Hsap 66e382fb00002243 BMP8B role in adipocyte differentiation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00002243/671ae02600000617 GO:0016361 activin receptor activity, type I GO:0045596 negative regulation of cell differentiation GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 66e382fb00002243 BMP8B role in adipocyte differentiation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00002243/671ae02600000629 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045596 negative regulation of cell differentiation GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 66e382fb00002243 BMP8B role in adipocyte differentiation inhibition (Human) NCBITaxon:9606 gomodel:66e382fb00002243/671ae02600000636 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045596 negative regulation of cell differentiation GO:0005634 nucleus false UniProtKB:P47872 SCTR Hsap 66e382fb00002293 Signaling by Secretin/SCT mediated by SCTR receptor (Human) NCBITaxon:9606 gomodel:66e382fb00002293/66e382fb00002294 GO:0015055 secretin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 66e382fb00002293 Signaling by Secretin/SCT mediated by SCTR receptor (Human) NCBITaxon:9606 gomodel:66e382fb00002293/66e382fb00002296 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 66e382fb00002293 Signaling by Secretin/SCT mediated by SCTR receptor (Human) NCBITaxon:9606 gomodel:66e382fb00002293/66e382fb00002298 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P09683 SCT Hsap 66e382fb00002293 Signaling by Secretin/SCT mediated by SCTR receptor (Human) NCBITaxon:9606 gomodel:66e382fb00002293/66e382fb00002320 GO:0005179 hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P42345 MTOR Hsap 66e382fb00002599 TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human). NCBITaxon:9606 gomodel:66e382fb00002599/66e382fb00002600 GO:0004674 protein serine/threonine kinase activity GO:0038203 TORC2 signaling GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 66e382fb00002599 TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human). NCBITaxon:9606 gomodel:66e382fb00002599/66e382fb00002629 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15530 PDPK1 Hsap 66e382fb00002599 TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human). NCBITaxon:9606 gomodel:66e382fb00002599/66e382fb00002634 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q9UHD2 TBK1 Hsap 66e382fb00002599 TBK1 activates the mTORC2 signaling by mediating phosphorylation of MTOR (Human). NCBITaxon:9606 gomodel:66e382fb00002599/66e382fb00002654 GO:0004674 protein serine/threonine kinase activity GO:1904515 positive regulation of TORC2 signaling false UniProtKB:Q14999 CUL7 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002663 GO:0160072 ubiquitin ligase complex scaffold activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q8N3Y1 FBXW8 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002672 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002681 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:P35568 IRS1 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002692 GO:0035591 signaling adaptor activity GO:0008286 insulin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P23443 RPS6KB1 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002700 GO:0004674 protein serine/threonine kinase activity GO:0046627 negative regulation of insulin receptor signaling pathway false UniProtKB:P42345 MTOR Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002708 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling false UniProtKB:P42345 MTOR Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002716 GO:0004674 protein serine/threonine kinase activity GO:0050821 protein stabilization false UniProtKB:Q9BPZ7 MAPKAP1 Hsap 66e382fb00002662 mTORC1 and mTORC2 inhibit insulin receptor signaling by promoting ubiquitination and degradation of IRS1 by the CUL7(FBXW8) complex (Human). NCBITaxon:9606 gomodel:66e382fb00002662/66e382fb00002728 GO:0140767 enzyme-substrate adaptor activity GO:0038203 TORC2 signaling false UniProtKB:Q96P20 NLRP3 Hsap 66e382fb00002738 ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) NCBITaxon:9606 gomodel:66e382fb00002738/66e382fb00002739 GO:0140299 molecular sensor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q96P20 NLRP3 Hsap 66e382fb00002738 ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) NCBITaxon:9606 gomodel:66e382fb00002738/66e382fb00002748 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q8TDX7 NEK7 Hsap 66e382fb00002738 ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) NCBITaxon:9606 gomodel:66e382fb00002738/66e382fb00002884 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q8WTX9 ZDHHC1 Hsap 66e382fb00002738 ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) NCBITaxon:9606 gomodel:66e382fb00002738/66e382fb00002898 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly false UniProtKB:O95835 LATS1 Hsap 66e382fb00002738 ZDHHC1 promotes activation of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, leading to NLRP3 phosphorylation by LATS1 and activation of NLRP3 by NEK7 (Human) NCBITaxon:9606 gomodel:66e382fb00002738/66e382fb00002905 GO:0004674 protein serine/threonine kinase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:Q8N884 CGAS Hsap 66f5faaa00000026 AARS2 mediates lactylation and inactivation of CGAS (Human) NCBITaxon:9606 gomodel:66f5faaa00000026/66f5faaa00000059 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 66f5faaa00000026 AARS2 mediates lactylation and inactivation of CGAS (Human) NCBITaxon:9606 gomodel:66f5faaa00000026/66f5faaa00000068 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q5JTZ9 AARS2 Hsap 66f5faaa00000026 AARS2 mediates lactylation and inactivation of CGAS (Human) NCBITaxon:9606 gomodel:66f5faaa00000026/66f5faaa00000102 GO:0141207 peptide lactyltransferase (ATP-dependent) activity GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q86WV6 STING1 Hsap 66f5faaa00000026 AARS2 mediates lactylation and inactivation of CGAS (Human) NCBITaxon:9606 gomodel:66f5faaa00000026/69729a3800007731 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9NYJ8 TAB2 Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000181 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000201 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000220 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000229 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000240 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000248 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9Y4K3 TRAF6 Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000309 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z6Z7 HUWE1 Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000316 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q9NQC7 CYLD Hsap 66f5faaa00000112 TRAF6 and HUWE1 catalyze branched-linked polyubiquitination that promote NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:66f5faaa00000112/66f5faaa00000329 GO:0061578 K63-linked deubiquitinase activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction false UniProtKB:Q96CB9 NSUN4 Hsap 66f5faaa00000763 NSUN4 catalyzes RNA 5-methylcytosine mark on mitochondrial double-stranded RNAs, which are recognized by C1QBP, promoting RNA degradation by the mitochondrial degradosome complex (Human). NCBITaxon:9606 gomodel:66f5faaa00000763/66f5faaa00000764 GO:0008173 RNA methyltransferase activity GO:1900864 mitochondrial RNA modification GO:0005759 mitochondrial matrix false UniProtKB:Q07021 C1QBP Hsap 66f5faaa00000763 NSUN4 catalyzes RNA 5-methylcytosine mark on mitochondrial double-stranded RNAs, which are recognized by C1QBP, promoting RNA degradation by the mitochondrial degradosome complex (Human). NCBITaxon:9606 gomodel:66f5faaa00000763/66f5faaa00000771 GO:0062153 C5-methylcytidine-containing RNA reader activity GO:0000957 mitochondrial RNA catabolic process GO:0005759 mitochondrial matrix false GO:0045025 mitochondrial degradosome 66f5faaa00000763 NSUN4 catalyzes RNA 5-methylcytosine mark on mitochondrial double-stranded RNAs, which are recognized by C1QBP, promoting RNA degradation by the mitochondrial degradosome complex (Human). NCBITaxon:9606 gomodel:66f5faaa00000763/66f5faaa00000778 GO:0000175 3'-5'-RNA exonuclease activity GO:0000957 mitochondrial RNA catabolic process GO:0005759 mitochondrial matrix false UniProtKB:Q9UK99 FBXO3 Hsap 66f5faaa00001170 RVFV NSs-FBXO3 E3 ligase mediates TFIIH complex degradation. (Human) NCBITaxon:9606 gomodel:66f5faaa00001170/66f5faaa00001176 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P21698 NSS NCBITaxon:11589 66f5faaa00001170 RVFV NSs-FBXO3 E3 ligase mediates TFIIH complex degradation. (Human) NCBITaxon:9606 gomodel:66f5faaa00001170/66f5faaa00001185 GO:0030674 protein-macromolecule adaptor activity GO:0140886 symbiont-mediated suppression of host interferon-mediated signaling pathway GO:0042025 host cell nucleus false GO:0000439 transcription factor TFIIH core complex 66f5faaa00001170 RVFV NSs-FBXO3 E3 ligase mediates TFIIH complex degradation. (Human) NCBITaxon:9606 gomodel:66f5faaa00001170/66f5faaa00001195 GO:0016251 RNA polymerase II general transcription initiation factor activity GO:0006366 transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q9BY21 GPR87 Hsap 67086be200000529 GPR87 role as a LPA receptor (Human) NCBITaxon:9606 gomodel:67086be200000529/67086be200000538 GO:0045028 G protein-coupled purinergic nucleotide receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P46937 YAP1 Hsap 67086be200000529 GPR87 role as a LPA receptor (Human) NCBITaxon:9606 gomodel:67086be200000529/67086be200001561 GO:0003712 transcription coregulator activity GO:0035329 hippo signaling GO:0005634 nucleus false UniProtKB:P52789 HK2 Hsap 67086be200000529 GPR87 role as a LPA receptor (Human) NCBITaxon:9606 gomodel:67086be200000529/67086be200001569 GO:0004396 hexokinase activity GO:0061621 canonical glycolysis GO:0005741 mitochondrial outer membrane false UniProtKB:Q8NI37 PPTC7 Hsap 67086be200001578 Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 (Human) NCBITaxon:9606 gomodel:67086be200001578/67086be200001579 GO:0030674 protein-macromolecule adaptor activity GO:1901525 negative regulation of mitophagy GO:0005741 mitochondrial outer membrane false UniProtKB:Q9UKA2 FBXL4 Hsap 67086be200001578 Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 (Human) NCBITaxon:9606 gomodel:67086be200001578/67086be200001590 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:1901525 negative regulation of mitophagy GO:0005741 mitochondrial outer membrane false UniProtKB:P62877 RBX1 Hsap 67086be200001578 Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 (Human) NCBITaxon:9606 gomodel:67086be200001578/67086be200001638 GO:0061630 ubiquitin protein ligase activity GO:1901525 negative regulation of mitophagy GO:0005737 cytoplasm false UniProtKB:Q12983 BNIP3 Hsap 67086be200001578 Negative regulation of BNIP3 and BNIP3L via PPTC7 and FBXL4 (Human) NCBITaxon:9606 gomodel:67086be200001578/67086be200001663 GO:0140580 mitochondrion autophagosome adaptor activity GO:0000423 mitophagy GO:0005741 mitochondrial outer membrane false UniProtKB:Q8IYV9 IZUMO1 Hsap 67086be200001601 Fertilization complex allows sperm-egg recognition during fertilization. (Human) NCBITaxon:9606 gomodel:67086be200001601/67086be200001602 GO:0048018 receptor ligand activity GO:0035036 sperm-egg recognition GO:0005886 plasma membrane false UniProtKB:A6ND01 IZUMO1R Hsap 67086be200001601 Fertilization complex allows sperm-egg recognition during fertilization. (Human) NCBITaxon:9606 gomodel:67086be200001601/67086be200001614 GO:0038023 signaling receptor activity GO:0035036 sperm-egg recognition GO:0005886 plasma membrane false UniProtKB:W5XKT8 SPACA6 Hsap 67086be200001601 Fertilization complex allows sperm-egg recognition during fertilization. (Human) NCBITaxon:9606 gomodel:67086be200001601/67086be200001625 GO:0030674 protein-macromolecule adaptor activity GO:0035036 sperm-egg recognition GO:0005886 plasma membrane false UniProtKB:Q6P7N7 TMEM81 Hsap 67086be200001601 Fertilization complex allows sperm-egg recognition during fertilization. (Human) NCBITaxon:9606 gomodel:67086be200001601/67086be200001645 GO:0030674 protein-macromolecule adaptor activity GO:0035036 sperm-egg recognition GO:0005886 plasma membrane false UniProtKB:P05067 APP Hsap 67086be200002981 Negative regulation of Amyloid-beta precursor protein/APP processing by SORL1 (Human) NCBITaxon:9606 gomodel:67086be200002981/67086be200002982 GO:0048018 receptor ligand activity GO:0031901 early endosome membrane false UniProtKB:Q92673 SORL1 Hsap 67086be200002981 Negative regulation of Amyloid-beta precursor protein/APP processing by SORL1 (Human) NCBITaxon:9606 gomodel:67086be200002981/671ae02600000212 GO:0140318 protein transporter activity GO:0042147 retrograde transport, endosome to Golgi GO:0031901 early endosome membrane false UniProtKB:P49768 PSEN1 Hsap 67086be200002981 Negative regulation of Amyloid-beta precursor protein/APP processing by SORL1 (Human) NCBITaxon:9606 gomodel:67086be200002981/671ae02600000732 GO:0004175 endopeptidase activity GO:0034205 amyloid-beta formation false UniProtKB:Q15796 SMAD2 Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000695 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0061450 trophoblast cell migration GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000702 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0061450 trophoblast cell migration GO:0005634 nucleus false UniProtKB:P36897 TGFBR1 Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000718 GO:0005025 transforming growth factor beta receptor activity, type I GO:0061450 trophoblast cell migration GO:0005886 plasma membrane false UniProtKB:P08253 MMP2 Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000793 GO:0004175 endopeptidase activity GO:0061450 trophoblast cell migration GO:0005576 extracellular region false UniProtKB:O14793 MSTN Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000802 GO:0005125 cytokine activity GO:0061450 trophoblast cell migration GO:0005576 extracellular region false UniProtKB:Q13705 ACVR2B Hsap 671ae02600000676 GDF8 role in trophoblast invasion (Human) NCBITaxon:9606 gomodel:671ae02600000676/671ae02600000810 GO:0016362 activin receptor activity, type II GO:0061450 trophoblast cell migration GO:0005886 plasma membrane false UniProtKB:Q14643 ITPR1 Hsap 671ae02600000821 Release of sequestered calcium ion into cytosol by ITPR1 upon 1D-myo-inositol 1,4,5-trisphosphate binding (Human) NCBITaxon:9606 gomodel:671ae02600000821/671ae02600000822 GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0051209 release of sequestered calcium ion into cytosol GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q14571 ITPR2 Hsap 671ae02600000964 Release of sequestered calcium ion into cytosol by ITPR2 upon 1D-myo-inositol 1,4,5-trisphosphate binding (Human) NCBITaxon:9606 gomodel:671ae02600000964/671ae02600001008 GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0051209 release of sequestered calcium ion into cytosol GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q14573 ITPR3 Hsap 671ae02600001023 Release of sequestered calcium ion into cytosol by ITPR3 upon 1D-myo-inositol 1,4,5-trisphosphate binding (Human) NCBITaxon:9606 gomodel:671ae02600001023/671ae02600001024 GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity GO:0051209 release of sequestered calcium ion into cytosol GO:0005789 endoplasmic reticulum membrane false UniProtKB:O00571 DDX3X Hsap 671ae02600001912 RNF39-mediated inhibition of RLR signaling pathway via K48 ubiquitination of DDX3X (Human) NCBITaxon:9606 gomodel:671ae02600001912/671ae02600001920 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14164 IKBKE Hsap 671ae02600001912 RNF39-mediated inhibition of RLR signaling pathway via K48 ubiquitination of DDX3X (Human) NCBITaxon:9606 gomodel:671ae02600001912/671ae02600001925 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005737 cytoplasm false UniProtKB:Q14653-5 IRF3 Hsap 671ae02600001912 RNF39-mediated inhibition of RLR signaling pathway via K48 ubiquitination of DDX3X (Human) NCBITaxon:9606 gomodel:671ae02600001912/671ae02600001940 GO:0001216 DNA-binding transcription activator activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q9H2S5 RNF39 Hsap 671ae02600001912 RNF39-mediated inhibition of RLR signaling pathway via K48 ubiquitination of DDX3X (Human) NCBITaxon:9606 gomodel:671ae02600001912/671ae02600001951 GO:0061630 ubiquitin protein ligase activity GO:0039532 negative regulation of cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q86WV6 STING1 Hsap 671ae02600001961 RNF39-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:671ae02600001961/671ae02600001973 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0000139 Golgi membrane false UniProtKB:Q9UHD2 TBK1 Hsap 671ae02600001961 RNF39-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:671ae02600001961/671ae02600001985 GO:0004674 protein serine/threonine kinase activity GO:0140896 cGAS/STING signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9H2S5 RNF39 Hsap 671ae02600001961 RNF39-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:671ae02600001961/671ae02600001995 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 671ae02600001961 RNF39-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:671ae02600001961/671ae02600002007 GO:0003700 DNA-binding transcription factor activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q9ULZ1 APLN Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002052 GO:0005179 hormone activity GO:0060183 apelin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P35414 APLNR Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002064 GO:0060182 apelin receptor activity GO:0060183 apelin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002087 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P32121 ARRB2 Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002096 GO:0060090 molecular adaptor activity GO:0002031 G protein-coupled receptor internalization GO:0005737 cytoplasm false UniProtKB:P49407 ARRB1 Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002105 GO:0060090 molecular adaptor activity GO:0002031 G protein-coupled receptor internalization GO:0005737 cytoplasm false UniProtKB:P35414 APLNR Hsap 671ae02600002051 Signaling by Apelin/APLN mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002051/671ae02600002130 GO:0140897 mechanoreceptor activity GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress GO:0005886 plasma membrane false UniProtKB:O14920 IKBKB Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002283 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002291 GO:0140311 protein sequestering activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002302 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002310 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P36544 CHRNA7 Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002348 GO:0004888 transmembrane signaling receptor activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005886 plasma membrane false UniProtKB:O00206 TLR4 Hsap 671ae02600002262 Negative regulation of canonical NF-kappaB signal transduction by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002262/671ae02600002565 GO:0004888 transmembrane signaling receptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005886 plasma membrane false UniProtKB:P0DMC3 APELA Hsap 671ae02600002587 Signaling by APELA mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002587/671ae02600002588 GO:0005179 hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P35414 APLNR Hsap 671ae02600002587 Signaling by APELA mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002587/671ae02600002597 GO:0008528 G protein-coupled peptide receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 671ae02600002587 Signaling by APELA mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002587/671ae02600002612 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P32121 ARRB2 Hsap 671ae02600002587 Signaling by APELA mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002587/671ae02600002621 GO:0060090 molecular adaptor activity GO:0002031 G protein-coupled receptor internalization GO:0005737 cytoplasm false UniProtKB:P49407 ARRB1 Hsap 671ae02600002587 Signaling by APELA mediated by APLNR receptor (Human) NCBITaxon:9606 gomodel:671ae02600002587/671ae02600002628 GO:0060090 molecular adaptor activity GO:0002031 G protein-coupled receptor internalization GO:0005737 cytoplasm false UniProtKB:P36544 CHRNA7 Hsap 671ae02600002661 Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002661/671ae02600002699 GO:0004888 transmembrane signaling receptor activity GO:1900016 negative regulation of cytokine production involved in inflammatory response GO:0005886 plasma membrane false UniProtKB:P40763 STAT3 Hsap 671ae02600002661 Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002661/671ae02600002721 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:1900016 negative regulation of cytokine production involved in inflammatory response GO:0005737 cytoplasm false UniProtKB:O60674 JAK2 Hsap 671ae02600002661 Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002661/671ae02600002753 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:1900016 negative regulation of cytokine production involved in inflammatory response GO:0005829 cytosol false UniProtKB:P26651 ZFP36 Hsap 671ae02600002661 Negative regulation of cytokine production involved in inflammatory response via STAT3 by CHRNA7 in macrophages (Human). NCBITaxon:9606 gomodel:671ae02600002661/671ae02600003121 GO:0160134 protein-RNA sequence-specific adaptor activity GO:1905869 negative regulation of 3'-UTR-mediated mRNA stabilization GO:0005737 cytoplasm false UniProtKB:Q9NZS9 BFAR Hsap 671ae02600002752 BFAR modulation of the unfolded protein response (UPR) via TMBIM6 (Human) NCBITaxon:9606 gomodel:671ae02600002752/671ae02600002763 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005789 endoplasmic reticulum membrane false UniProtKB:P55061 TMBIM6 Hsap 671ae02600002752 BFAR modulation of the unfolded protein response (UPR) via TMBIM6 (Human) NCBITaxon:9606 gomodel:671ae02600002752/671ae02600002776 GO:0060698 endoribonuclease inhibitor activity GO:1903895 negative regulation of IRE1-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:O75460 ERN1 Hsap 671ae02600002752 BFAR modulation of the unfolded protein response (UPR) via TMBIM6 (Human) NCBITaxon:9606 gomodel:671ae02600002752/671ae02600002787 GO:0004521 RNA endonuclease activity GO:0036498 IRE1-mediated unfolded protein response GO:0005789 endoplasmic reticulum membrane false UniProtKB:P17861 XBP1 Hsap 671ae02600002752 BFAR modulation of the unfolded protein response (UPR) via TMBIM6 (Human) NCBITaxon:9606 gomodel:671ae02600002752/671ae02600002795 GO:0003700 DNA-binding transcription factor activity GO:0036498 IRE1-mediated unfolded protein response GO:0005634 nucleus false UniProtKB:Q86VZ1 P2RY8 Hsap 671ae02600003459 P2RY8-mediated signaling via G-alpha-13activating RhoA following activation by S-geranylgeranyl-glutathione (Human). NCBITaxon:9606 gomodel:671ae02600003459/671ae02600003461 GO:0004930 G protein-coupled receptor activity GO:0160221 Rho-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q14344 GNA13 Hsap 671ae02600003459 P2RY8-mediated signaling via G-alpha-13activating RhoA following activation by S-geranylgeranyl-glutathione (Human). NCBITaxon:9606 gomodel:671ae02600003459/671ae02600003468 GO:0003925 G protein activity GO:0160221 Rho-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9NZN5 ARHGEF12 Hsap 671ae02600003459 P2RY8-mediated signaling via G-alpha-13activating RhoA following activation by S-geranylgeranyl-glutathione (Human). NCBITaxon:9606 gomodel:671ae02600003459/67369e7600005199 GO:0005085 guanyl-nucleotide exchange factor activity GO:0160221 Rho-activating G protein-coupled receptor signaling pathway false UniProtKB:P61586 RHOA Hsap 671ae02600003459 P2RY8-mediated signaling via G-alpha-13activating RhoA following activation by S-geranylgeranyl-glutathione (Human). NCBITaxon:9606 gomodel:671ae02600003459/67369e7600005207 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:P26717 KLRC2 Hsap 67369e7600000015 NK-cell activation by HLA-E via KLRD1-KLRC2 receptor complex (Human) NCBITaxon:9606 gomodel:67369e7600000015/67369e7600000016 GO:0062081 activating MHC class Ib receptor activity GO:0002228 natural killer cell mediated immunity GO:0005886 plasma membrane false UniProtKB:P13747 HLA-E Hsap 67369e7600000015 NK-cell activation by HLA-E via KLRD1-KLRC2 receptor complex (Human) NCBITaxon:9606 gomodel:67369e7600000015/67369e7600000023 GO:0048018 receptor ligand activity GO:0002519 natural killer cell tolerance induction GO:0005576 extracellular region false UniProtKB:Q13241 KLRD1 Hsap 67369e7600000015 NK-cell activation by HLA-E via KLRD1-KLRC2 receptor complex (Human) NCBITaxon:9606 gomodel:67369e7600000015/67369e7600000033 GO:0030108 HLA-A specific activating MHC class I receptor activity GO:0002228 natural killer cell mediated immunity GO:0005886 plasma membrane false UniProtKB:O43914 TYROBP Hsap 67369e7600000015 NK-cell activation by HLA-E via KLRD1-KLRC2 receptor complex (Human) NCBITaxon:9606 gomodel:67369e7600000015/67369e7600000043 GO:0030674 protein-macromolecule adaptor activity GO:0002228 natural killer cell mediated immunity GO:0005886 plasma membrane false UniProtKB:P36544 CHRNA7 Hsap 67369e7600000368 CHRNA7 homopentameric ligand-gated cation channel activated by Nicotine (Human). NCBITaxon:9606 gomodel:67369e7600000368/67369e7600000369 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0007268 chemical synaptic transmission GO:0045211 postsynaptic membrane false UniProtKB:P36544 CHRNA7 Hsap 67369e7600000417 CHRNA7 homopentameric ligand-gated cation channel activated by Cytisine (Human). NCBITaxon:9606 gomodel:67369e7600000417/67369e7600000418 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0007268 chemical synaptic transmission GO:0045211 postsynaptic membrane false UniProtKB:O00182 LGALS9 Hsap 67369e7600000521 Regulation of HAVCR2/TIM-3 receptor by ZDHHC9-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:67369e7600000521/67369e7600000522 GO:0048018 receptor ligand activity GO:0002826 negative regulation of T-helper 1 type immune response GO:0005576 extracellular region false UniProtKB:Q8TDQ0 HAVCR2 Hsap 67369e7600000521 Regulation of HAVCR2/TIM-3 receptor by ZDHHC9-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:67369e7600000521/67369e7600000531 GO:0004888 transmembrane signaling receptor activity GO:0002826 negative regulation of T-helper 1 type immune response GO:0005886 plasma membrane false UniProtKB:Q9Y397 ZDHHC9 Hsap 67369e7600000521 Regulation of HAVCR2/TIM-3 receptor by ZDHHC9-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:67369e7600000521/67369e7600000540 GO:0016409 palmitoyltransferase activity GO:0018230 peptidyl-L-cysteine S-palmitoylation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q86TM6 SYVN1 Hsap 67369e7600000521 Regulation of HAVCR2/TIM-3 receptor by ZDHHC9-mediated palmitoylation (Human) NCBITaxon:9606 gomodel:67369e7600000521/67369e7600000547 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005789 endoplasmic reticulum membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600000638 Ca(2+) selectively potentiates (CHRNA4)3:(CHRNB2)2 stoichiometry of acetylcholine receptor signaling pathway gated by Acetylcholine. (Human) NCBITaxon:9606 gomodel:67369e7600000638/67369e7600000639 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600000669 (CHRNA4)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by Acetylcholine, sodium transport. (Human) NCBITaxon:9606 gomodel:67369e7600000669/67369e7600000670 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600000699 (CHRNA4)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by Nicotine. (Human) NCBITaxon:9606 gomodel:67369e7600000699/67369e7600000700 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600000726 (CHRNA4)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by Acetylcholine, calcium transport. (Human) NCBITaxon:9606 gomodel:67369e7600000726/67369e7600000727 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600001410 (CHRNA7)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by Acetylcholine, calcium transport. (Human) NCBITaxon:9606 gomodel:67369e7600001410/67369e7600001411 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600001439 (CHRNA7)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by amyloid beta complex, calcium transport. (Human) NCBITaxon:9606 gomodel:67369e7600001439/67369e7600001440 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0106003 amyloid-beta complex 67369e7600001439 (CHRNA7)3:(CHRNB2)2 acetylcholine receptor signaling pathway gated by amyloid beta complex, calcium transport. (Human) NCBITaxon:9606 gomodel:67369e7600001439/67369e7600001471 GO:0048018 receptor ligand activity GO:0032224 positive regulation of synaptic transmission, cholinergic GO:0043083 synaptic cleft false UniProtKB:P22557 ALAS2 Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001711 GO:0003870 5-aminolevulinate synthase activity GO:0006785 heme B biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P13716 ALAD Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001721 GO:0004655 porphobilinogen synthase activity GO:0006785 heme B biosynthetic process GO:0005829 cytosol false UniProtKB:P08397 HMBS Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001743 GO:0004418 hydroxymethylbilane synthase activity GO:0006785 heme B biosynthetic process GO:0005829 cytosol false UniProtKB:P10746 UROS Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001760 GO:0004852 uroporphyrinogen-III synthase activity GO:0006785 heme B biosynthetic process GO:0005829 cytosol false UniProtKB:P06132 UROD Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001778 GO:0004853 uroporphyrinogen decarboxylase activity GO:0006785 heme B biosynthetic process GO:0005829 cytosol false UniProtKB:P36551 CPOX Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001799 GO:0004109 coproporphyrinogen oxidase activity GO:0006785 heme B biosynthetic process GO:0005758 mitochondrial intermembrane space false UniProtKB:P50336 PPOX Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001811 GO:0004729 protoporphyrinogen oxidase activity, oxygen as acceptor GO:0006785 heme B biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P22830 FECH Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001824 GO:0004325 protoporphyrin ferrochelatase activity GO:0006785 heme B biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P15104 GLUL Hsap 67369e7600001710 Heme B biosynthetic process, including ammonium detoxification by GLUL (Human). NCBITaxon:9606 gomodel:67369e7600001710/67369e7600001835 GO:0004356 glutamine synthetase activity GO:0097275 intracellular ammonium homeostasis GO:0005829 cytosol false UniProtKB:Q92956 TNFRSF14 Hsap 67369e7600001853 Negative role of BTLA in T cell proliferation upon binding to TNFRSF14 (Human) NCBITaxon:9606 gomodel:67369e7600001853/67369e7600001854 GO:0048018 receptor ligand activity GO:0042130 negative regulation of T cell proliferation GO:0005886 plasma membrane false UniProtKB:Q7Z6A9 BTLA Hsap 67369e7600001853 Negative role of BTLA in T cell proliferation upon binding to TNFRSF14 (Human) NCBITaxon:9606 gomodel:67369e7600001853/67369e7600001861 GO:0038023 signaling receptor activity GO:0042130 negative regulation of T cell proliferation GO:0005886 plasma membrane false UniProtKB:Q06124 PTPN11 Hsap 67369e7600001853 Negative role of BTLA in T cell proliferation upon binding to TNFRSF14 (Human) NCBITaxon:9606 gomodel:67369e7600001853/67369e7600001872 GO:0004721 phosphoprotein phosphatase activity GO:0042130 negative regulation of T cell proliferation GO:0005737 cytoplasm false UniProtKB:Q96EH8 NEURL3 Hsap 67369e7600002467 LINCR amplifies the TLR-mediated signals through direct degradation of MKP1 (Human) NCBITaxon:9606 gomodel:67369e7600002467/67369e7600002468 GO:0061630 ubiquitin protein ligase activity GO:1901800 positive regulation of proteasomal protein catabolic process GO:0005737 cytoplasm false UniProtKB:P28562 DUSP1 Hsap 67369e7600002467 LINCR amplifies the TLR-mediated signals through direct degradation of MKP1 (Human) NCBITaxon:9606 gomodel:67369e7600002467/67369e7600002475 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity GO:0043409 negative regulation of MAPK cascade GO:0005737 cytoplasm false UniProtKB:P28482 MAPK1 Hsap 67369e7600002467 LINCR amplifies the TLR-mediated signals through direct degradation of MKP1 (Human) NCBITaxon:9606 gomodel:67369e7600002467/67369e7600002487 GO:0004674 protein serine/threonine kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:O00206 TLR4 Hsap 67369e7600002467 LINCR amplifies the TLR-mediated signals through direct degradation of MKP1 (Human) NCBITaxon:9606 gomodel:67369e7600002467/67369e7600002496 GO:0038023 signaling receptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005886 plasma membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600003097 (CHRNA4)2:(CHRNB2)3 acetylcholine receptor signaling pathway gated by Acetylcholine, calcium transport. (Human) NCBITaxon:9606 gomodel:67369e7600003097/67369e7600003098 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600003135 (CHRNA4)2:(CHRNB2)3 acetylcholine receptor signaling pathway gated by Nicotine. (Human) NCBITaxon:9606 gomodel:67369e7600003135/67369e7600003136 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 67369e7600003173 (CHRNA4)2:(CHRNB2)3 acetylcholine receptor signaling pathway gated by Acetylcholine, sodium transport. (Human) NCBITaxon:9606 gomodel:67369e7600003173/67369e7600003174 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false UniProtKB:Q14330 GPR18 Hsap 67369e7600004124 Resolvin D2/GPR18-mediated activation of phagocytosis (Human) NCBITaxon:9606 gomodel:67369e7600004124/67369e7600004128 GO:0004930 G protein-coupled receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67369e7600004124 Resolvin D2/GPR18-mediated activation of phagocytosis (Human) NCBITaxon:9606 gomodel:67369e7600004124/67369e7600004136 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 67369e7600004124 Resolvin D2/GPR18-mediated activation of phagocytosis (Human) NCBITaxon:9606 gomodel:67369e7600004124/67369e7600004145 GO:0003700 DNA-binding transcription factor activity GO:0050766 positive regulation of phagocytosis GO:0005634 nucleus false UniProtKB:P17612 PRKACA Hsap 67369e7600004124 Resolvin D2/GPR18-mediated activation of phagocytosis (Human) NCBITaxon:9606 gomodel:67369e7600004124/67369e7600004152 GO:0004674 protein serine/threonine kinase activity GO:0050766 positive regulation of phagocytosis GO:0005737 cytoplasm false GO:0005892 acetylcholine-gated channel complex 67369e7600005223 Regulation of appetite by (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine in POMC neurons. (Human) NCBITaxon:9606 gomodel:67369e7600005223/67369e7600005225 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0032098 regulation of appetite GO:0045202 synapse false UniProtKB:P01189 POMC Hsap 67369e7600005223 Regulation of appetite by (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine in POMC neurons. (Human) NCBITaxon:9606 gomodel:67369e7600005223/67369e7600005244 GO:0005179 hormone activity GO:0032098 regulation of appetite GO:0005576 extracellular region false GO:0005892 acetylcholine-gated channel complex 67369e7600005262 (CHRNA3)3:(CHRNB4)2 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:67369e7600005262/67369e7600005263 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000029 Low agonist sensitivity (CHRNA2)3:(CHRNB2)2 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:675b862c00000029/675b862c00000030 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000055 Low agonist sensitivity (CHRNA2)3:(CHRNB2)2 nAChR activated by Acetylcholine. (Human) NCBITaxon:9606 gomodel:675b862c00000055/675b862c00000056 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000081 High agonist sensitivity (CHRNA2)2:(CHRNB2)3 nAChR activated by Acetylcholine. (Human) NCBITaxon:9606 gomodel:675b862c00000081/675b862c00000082 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000107 High agonist sensitivity (CHRNA2)2:(CHRNB2)3 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:675b862c00000107/675b862c00000108 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000133 High agonist sensitivity (CHRNA2)2:(CHRNB4)3 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:675b862c00000133/675b862c00000134 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000159 High agonist sensitivity (CHRNA2)2:(CHRNB4)3 nAChR activated by Acetylcholine. (Human) NCBITaxon:9606 gomodel:675b862c00000159/675b862c00000160 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000185 Low agonist sensitivity (CHRNA2)3:(CHRNB4)2 nAChR activated by Acetylcholine. (Human) NCBITaxon:9606 gomodel:675b862c00000185/675b862c00000186 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 675b862c00000211 Low agonist sensitivity (CHRNA2)3:(CHRNB4)2 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:675b862c00000211/675b862c00000212 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false UniProtKB:Q01970 PLCB3 Hsap 675b862c00000237 OXGR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3, DAG) following itaconate-binding (Human). NCBITaxon:9606 gomodel:675b862c00000237/675b862c00000239 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P29992 GNA11 Hsap 675b862c00000237 OXGR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3, DAG) following itaconate-binding (Human). NCBITaxon:9606 gomodel:675b862c00000237/675b862c00000273 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96P68 OXGR1 Hsap 675b862c00000237 OXGR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3, DAG) following itaconate-binding (Human). NCBITaxon:9606 gomodel:675b862c00000237/675b862c00000281 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q5T2R2 PDSS1 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001471 GO:0097269 all-trans-decaprenyl-diphosphate synthase activity GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false UniProtKB:Q86YH6 PDSS2 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001478 GO:0097269 all-trans-decaprenyl-diphosphate synthase activity GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false UniProtKB:Q96H96 COQ2 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001485 GO:0008412 4-hydroxybenzoate polyprenyltransferase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q9Y2Z9 COQ6 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001496 GO:0106364 4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q9NZJ6 COQ3 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001509 GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q6P4F2-2 FDX2 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001519 GO:0009055 electron transfer activity GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false UniProtKB:P22570 FDXR Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/675b862c00001526 GO:0004324 ferredoxin-NADP+ reductase activity GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false UniProtKB:Q9NZJ6 COQ3 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000017 GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q9Y2Z9 COQ6 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000028 GO:0120538 2-methoxy-6-polyprenolphenol 4-hydroxylase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q9Y3A0 COQ4 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000039 GO:0120539 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q5HYK3 COQ5 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000052 GO:0008425 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity GO:0006744 ubiquinone biosynthetic process GO:0005743 mitochondrial inner membrane false CHEBI:36080 protein 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000062 GO:0004497 monooxygenase activity GO:0006744 ubiquinone biosynthetic process false UniProtKB:Q99807 COQ7 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000076 GO:0160224 3-demethoxyubiquinone 3-hydroxylase (NADH) activity GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false UniProtKB:O75208 COQ9 Hsap 675b862c00001470 Ubiquinone biosynthetic process (Human). NCBITaxon:9606 gomodel:675b862c00001470/678073a900000113 GO:0019840 isoprenoid binding GO:0006744 ubiquinone biosynthetic process GO:0005739 mitochondrion false GO:0005892 acetylcholine-gated channel complex 678073a900000195 CHRNA3:CHRNB4 nAChR activity in synaptic transmission involved in micturition. (Human) NCBITaxon:9606 gomodel:678073a900000195/678073a900000196 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P36544 CHRNA7 Hsap 678073a900000353 CHRNA7 nAChR activity in synaptic transmission involved in micturition. (Human) NCBITaxon:9606 gomodel:678073a900000353/678073a900000357 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q96P20 NLRP3 Hsap 678073a900001471 NLRP3 ubiquitination by TRIM65 leading to inhibition of inflammasome formation (Human) NCBITaxon:9606 gomodel:678073a900001471/678073a900001473 GO:0060090 molecular adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q8TDX7 NEK7 Hsap 678073a900001471 NLRP3 ubiquitination by TRIM65 leading to inhibition of inflammasome formation (Human) NCBITaxon:9606 gomodel:678073a900001471/678073a900001482 GO:0140677 molecular function activator activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005737 cytoplasm false UniProtKB:Q6PJ69 TRIM65 Hsap 678073a900001471 NLRP3 ubiquitination by TRIM65 leading to inhibition of inflammasome formation (Human) NCBITaxon:9606 gomodel:678073a900001471/678073a900001535 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:O95786 RIGI Hsap 678073a900001503 Ubiquitination of RIGI and MAVS by MARCHF5 leading to inhibition of cytosolic pattern recoognition pathway (Human) NCBITaxon:9606 gomodel:678073a900001503/678073a900001554 GO:0038187 pattern recognition receptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q7Z434 MAVS Hsap 678073a900001503 Ubiquitination of RIGI and MAVS by MARCHF5 leading to inhibition of cytosolic pattern recoognition pathway (Human) NCBITaxon:9606 gomodel:678073a900001503/678073a900001561 GO:0035591 signaling adaptor activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:Q9UHD2 TBK1 Hsap 678073a900001503 Ubiquitination of RIGI and MAVS by MARCHF5 leading to inhibition of cytosolic pattern recoognition pathway (Human) NCBITaxon:9606 gomodel:678073a900001503/678073a900001569 GO:0004674 protein serine/threonine kinase activity GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9NX47 MARCHF5 Hsap 678073a900001503 Ubiquitination of RIGI and MAVS by MARCHF5 leading to inhibition of cytosolic pattern recoognition pathway (Human) NCBITaxon:9606 gomodel:678073a900001503/678073a900001579 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005741 mitochondrial outer membrane false UniProtKB:Q86WV6 STING1 Hsap 678073a900001594 MARCHF5-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:678073a900001594/678073a900001595 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0000139 Golgi membrane false UniProtKB:Q9UHD2 TBK1 Hsap 678073a900001594 MARCHF5-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:678073a900001594/678073a900001605 GO:0004674 protein serine/threonine kinase activity GO:0140896 cGAS/STING signaling pathway GO:0005737 cytoplasm false UniProtKB:Q14653 IRF3 Hsap 678073a900001594 MARCHF5-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:678073a900001594/678073a900001625 GO:0003700 DNA-binding transcription factor activity GO:0140896 cGAS/STING signaling pathway GO:0005634 nucleus false UniProtKB:Q9NX47 MARCHF5 Hsap 678073a900001594 MARCHF5-mediated activation of cGAS-STING via K63 ubiquitination of STING1 (Human) NCBITaxon:9606 gomodel:678073a900001594/678073a900001637 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005741 mitochondrial outer membrane false UniProtKB:P36896 ACVR1B Hsap 678073a900001673 Inhibin A-mediated suppression of activin A signaling pathway (Human) NCBITaxon:9606 gomodel:678073a900001673/678073a900001674 GO:0016361 activin receptor activity, type I GO:0032924 activin receptor signaling pathway GO:0005886 plasma membrane false GO:0043509 activin A complex 678073a900001673 Inhibin A-mediated suppression of activin A signaling pathway (Human) NCBITaxon:9606 gomodel:678073a900001673/678073a900001681 GO:0005125 cytokine activity GO:0032924 activin receptor signaling pathway GO:0005576 extracellular region false GO:0043512 inhibin A complex 678073a900001673 Inhibin A-mediated suppression of activin A signaling pathway (Human) NCBITaxon:9606 gomodel:678073a900001673/678073a900001719 GO:0140311 protein sequestering activity GO:0032926 negative regulation of activin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P27037 ACVR2A Hsap 678073a900001673 Inhibin A-mediated suppression of activin A signaling pathway (Human) NCBITaxon:9606 gomodel:678073a900001673/678073a900001726 GO:0016362 activin receptor activity, type II GO:0032924 activin receptor signaling pathway GO:0005886 plasma membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003437 (CHRNA3:CHRNB4)2:CHRNA5 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:678073a900003437/678073a900003438 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003467 (CHRNA4:CHRNB2)2:CHRNA5 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:678073a900003467/678073a900003468 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003497 (CHRNA3:CHRNB2)2:CHRNA5 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:678073a900003497/678073a900003498 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003527 (CHRNA3:CHRNB2)2:CHRNA5 nAChR activated by acetylcholine. (Human) NCBITaxon:9606 gomodel:678073a900003527/678073a900003528 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003555 (CHRNA3:CHRNB4)2:CHRNA5 nAChR activated by acetylcholine. (Human) NCBITaxon:9606 gomodel:678073a900003555/678073a900003556 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003583 (CHRNA4:CHRNB2)2:CHRNA5 nAChR activated by acetylcholine. (Human) NCBITaxon:9606 gomodel:678073a900003583/678073a900003584 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0042734 presynaptic membrane false GO:0005892 acetylcholine-gated channel complex 678073a900003616 (CHRNA3:CHRNB4)2:CHRNB3 nAChR activated by acetylcholine. (Human) NCBITaxon:9606 gomodel:678073a900003616/678073a900003617 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 678073a900003657 (CHRNA6:CHRNB4)2:CHRNB3 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:678073a900003657/678073a900003658 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false GO:0005892 acetylcholine-gated channel complex 678073a900003708 (CHRNA6:CHRNB2)2:CHRNB3 nAChR activated by nicotine. (Human) NCBITaxon:9606 gomodel:678073a900003708/678073a900003709 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0045202 synapse false UniProtKB:Q14534 SQLE Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000579 GO:0004506 squalene monooxygenase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true sterol_commitment_squalene_to_lanosterol UniProtKB:P48449 LSS Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000596 GO:0000250 lanosterol synthase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true sterol_commitment_squalene_to_lanosterol UniProtKB:P37268 FDFT1 Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000606 GO:0051996 squalene synthase [NAD(P)H] activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true sterol_commitment_squalene_to_lanosterol UniProtKB:P14324 FDPS Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000616 GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity GO:0006695 cholesterol biosynthetic process GO:0005737 cytoplasm false UniProtKB:P14324 FDPS Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000626 GO:0004161 dimethylallyltranstransferase activity GO:0006695 cholesterol biosynthetic process GO:0005737 cytoplasm false UniProtKB:Q13907 IDI1 Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000880 GO:0004452 isopentenyl-diphosphate delta-isomerase activity GO:0006695 cholesterol biosynthetic process GO:0005737 cytoplasm false UniProtKB:P53602 MVD Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000888 GO:0004163 diphosphomevalonate decarboxylase activity GO:0006695 cholesterol biosynthetic process GO:0005737 cytoplasm true mevalonate_pathway UniProtKB:Q15126 PMVK Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000900 GO:0004631 phosphomevalonate kinase activity GO:0006695 cholesterol biosynthetic process GO:0005829 cytosol true mevalonate_pathway UniProtKB:Q03426 MVK Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000910 GO:0004496 mevalonate kinase activity GO:0006695 cholesterol biosynthetic process GO:0005829 cytosol true mevalonate_pathway UniProtKB:P04035 HMGCR Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000920 GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true mevalonate_pathway UniProtKB:Q01581 HMGCS1 Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000930 GO:0004421 hydroxymethylglutaryl-CoA synthase activity GO:0006695 cholesterol biosynthetic process GO:0005737 cytoplasm true mevalonate_pathway UniProtKB:Q9BWD1 ACAT2 Hsap 6796b94c00000576 Lanosterol biosynthesis (Human) NCBITaxon:9606 gomodel:6796b94c00000576/6796b94c00000942 GO:0003985 acetyl-CoA C-acetyltransferase activity GO:0006629 lipid metabolic process GO:0005737 cytoplasm false UniProtKB:Q14534 SQLE Hsap 6796b94c00001105 Regulation of cholesterol biosynthesis by MARCH6 via SQLE degradation (Human) NCBITaxon:9606 gomodel:6796b94c00001105/6796b94c00001228 GO:0004506 squalene monooxygenase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true sterol_commitment_squalene_to_lanosterol UniProtKB:P48449 LSS Hsap 6796b94c00001105 Regulation of cholesterol biosynthesis by MARCH6 via SQLE degradation (Human) NCBITaxon:9606 gomodel:6796b94c00001105/6796b94c00001239 GO:0000250 lanosterol synthase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true sterol_commitment_squalene_to_lanosterol UniProtKB:O60337 MARCHF6 Hsap 6796b94c00001105 Regulation of cholesterol biosynthesis by MARCH6 via SQLE degradation (Human) NCBITaxon:9606 gomodel:6796b94c00001105/6796b94c00001250 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q16850 CYP51A1 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00001562 GO:0008398 sterol 14-demethylase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:O76062 TM7SF2 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00001572 GO:0050613 Delta14-sterol reductase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15800 MSMO1 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00001582 GO:0000254 C-4 methylsterol oxidase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:Q15738 NSDHL Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00001770 GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:P56937 HSD17B7 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002784 GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15800 MSMO1 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002794 GO:0000254 C-4 methylsterol oxidase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:Q15738 NSDHL Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002804 GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:P56937 HSD17B7 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002814 GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15125 EBP Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002826 GO:0000247 C-8 sterol isomerase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:O75845 SC5D Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002842 GO:0050046 delta7-sterol 5(6)-desaturase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:Q9UBM7 DHCR7 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002852 GO:0047598 7-dehydrocholesterol reductase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane true cholesterol_synthesis_post_lanosterol UniProtKB:Q15392 DHCR24 Hsap 6796b94c00001560 Cholesterol biosynthesis from lanosterol (Human) NCBITaxon:9606 gomodel:6796b94c00001560/6796b94c00002862 GO:0000246 Delta24(24-1) sterol reductase activity GO:0006695 cholesterol biosynthetic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q676U5 ATG16L1 Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001874 GO:0043495 protein-membrane adaptor activity GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9H1Y0 ATG5 Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001882 GO:0019776 Atg8-family ligase activity GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q9H492 MAP1LC3A Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001892 GO:0005543 phospholipid binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9GZQ8 MAP1LC3B Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001899 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9BXW4 MAP1LC3C Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001901 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:O95166 GABARAP Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001906 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9H0R8 GABARAPL1 Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001910 GO:0005543 phospholipid binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:P60520 GABARAPL2 Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00001914 GO:0008429 phosphatidylethanolamine binding GO:0000045 autophagosome assembly GO:0000421 autophagosome membrane false UniProtKB:Q9H082 RAB33B Hsap 6796b94c00001787 RAB33B recruitment of ATG16L1-ATG12-ATG5 complex to phagophore (Human) NCBITaxon:9606 gomodel:6796b94c00001787/6796b94c00002081 GO:0003925 G protein activity GO:0034497 protein localization to phagophore assembly site GO:0034045 phagophore assembly site membrane false UniProtKB:P50613 CDK7 Hsap 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002253 GO:0140836 RNA polymerase II CTD heptapeptide repeat S5 kinase activity GO:0006367 transcription initiation at RNA polymerase II promoter GO:0005634 nucleus false GO:0032044 DSIF complex 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002262 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false GO:0032021 NELF complex 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002273 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false UniProtKB:P50750 CDK9 Hsap 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002296 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity GO:0006368 transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q96QC0 PPP1R10 Hsap 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002308 GO:0140767 enzyme-substrate adaptor activity GO:0001111 RNA polymerase II promoter clearance GO:0000785 chromatin false UniProtKB:P62136 PPP1CA Hsap 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/6796b94c00002322 GO:0004722 protein serine/threonine phosphatase activity GO:0001111 RNA polymerase II promoter clearance GO:0005634 nucleus false UniProtKB:P24928 POLR2A Hsap 6796b94c00002252 Transcription-pause release by the PNUTS-PP1 complex (Human). NCBITaxon:9606 gomodel:6796b94c00002252/67b1629100003450 GO:0003899 DNA-directed RNA polymerase activity GO:0006368 transcription elongation by RNA polymerase II GO:0005694 chromosome false UniProtKB:P53007 SLC25A1 Hsap 6796b94c00002691 SLC25A1 negatively regulates ferroptosis (Human) NCBITaxon:9606 gomodel:6796b94c00002691/6796b94c00002692 GO:0071913 citrate secondary active transmembrane transporter activity GO:0006843 mitochondrial citrate transmembrane transport GO:0031966 mitochondrial membrane false UniProtKB:P53396 ACLY Hsap 6796b94c00002691 SLC25A1 negatively regulates ferroptosis (Human) NCBITaxon:9606 gomodel:6796b94c00002691/6796b94c00002709 GO:0003878 ATP citrate synthase activity GO:0006085 acetyl-CoA biosynthetic process GO:0005829 cytosol false UniProtKB:Q9BRQ8 AIFM2 Hsap 6796b94c00002691 SLC25A1 negatively regulates ferroptosis (Human) NCBITaxon:9606 gomodel:6796b94c00002691/6796b94c00002719 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0110076 negative regulation of ferroptosis GO:0005829 cytosol false UniProtKB:Q92831 KAT2B Hsap 6796b94c00002691 SLC25A1 negatively regulates ferroptosis (Human) NCBITaxon:9606 gomodel:6796b94c00002691/6796b94c00002735 GO:0061733 protein-lysine-acetyltransferase activity GO:0110076 negative regulation of ferroptosis GO:0005737 cytoplasm false UniProtKB:Q03468 ERCC6 Hsap 6796b94c00002938 Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). NCBITaxon:9606 gomodel:6796b94c00002938/6796b94c00002939 GO:0140463 chromatin-protein adaptor activity GO:0071168 protein localization to chromatin GO:0090734 site of DNA damage false UniProtKB:Q13216 ERCC8 Hsap 6796b94c00002938 Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). NCBITaxon:9606 gomodel:6796b94c00002938/6796b94c00002950 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0016567 protein ubiquitination GO:0090734 site of DNA damage false UniProtKB:P62877 RBX1 Hsap 6796b94c00002938 Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). NCBITaxon:9606 gomodel:6796b94c00002938/6796b94c00002962 GO:0061630 ubiquitin protein ligase activity GO:0016567 protein ubiquitination GO:0090734 site of DNA damage false UniProtKB:Q2YD98 UVSSA Hsap 6796b94c00002938 Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). NCBITaxon:9606 gomodel:6796b94c00002938/6796b94c00002974 GO:0140870 RNA polymerase inhibitor activity GO:0006283 transcription-coupled nucleotide-excision repair GO:0090734 site of DNA damage false UniProtKB:P60002 ELOF1 Hsap 6796b94c00002938 Transcription-coupled nucleotide-excision repair by ERRC6, ERCC8, ELOF1 and UVSSA (Human). NCBITaxon:9606 gomodel:6796b94c00002938/6796b94c00002982 GO:0030674 protein-macromolecule adaptor activity GO:0006283 transcription-coupled nucleotide-excision repair false UniProtKB:P0DTC2 S protein Scov2 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00004997 GO:0046789 host cell surface receptor binding GO:0046718 symbiont entry into host cell GO:0044228 host cell surface false UniProtKB:O15393 TMPRSS2 Hsap 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00004999 GO:0004252 serine-type endopeptidase activity GO:0098670 entry receptor-mediated virion attachment to host cell GO:0005886 plasma membrane false UniProtKB:P09958 FURIN Hsap 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00005002 GO:0008236 serine-type peptidase activity false UniProtKB:P0DTC2-PRO_0000449649 Spike protein S2 Scov2 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00005041 GO:0140522 fusogenic activity GO:0039654 fusion of virus membrane with host endosome membrane GO:0005768 endosome false UniProtKB:O95992 CH25H Hsap 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00005067 GO:0001567 cholesterol 25-hydroxylase activity false UniProtKB:P24752 ACAT1 Hsap 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00005069 GO:0034736 cholesterol O-acyltransferase activity GO:0005783 endoplasmic reticulum true ketogenesis UniProtKB:Q9BYF1 ACE2 Hsap 6796b94c00004996 Sars-CoV2 entry into host cell (HUman-SARS-CoV-2) NCBITaxon:9606 gomodel:6796b94c00004996/6796b94c00005130 GO:0004175 endopeptidase activity GO:0098670 entry receptor-mediated virion attachment to host cell GO:0005886 plasma membrane false UniProtKB:P19021 PAM Hsap 6796b94c00005197 The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). NCBITaxon:9606 gomodel:6796b94c00005197/6796b94c00005198 GO:0004504 peptidylglycine monooxygenase activity GO:0001519 peptide amidation false UniProtKB:P19021 PAM Hsap 6796b94c00005197 The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). NCBITaxon:9606 gomodel:6796b94c00005197/6796b94c00005206 GO:0004598 peptidylamidoglycolate lyase activity GO:0001519 peptide amidation false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00005197 The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). NCBITaxon:9606 gomodel:6796b94c00005197/6796b94c00005215 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13616 CUL1 Hsap 6796b94c00005197 The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). NCBITaxon:9606 gomodel:6796b94c00005197/6796b94c00005223 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6796b94c00005197 The SCF(FBXO31) complex mediates ubiquitination of proteins amidated in response to oxidative stress (Human). NCBITaxon:9606 gomodel:6796b94c00005197/6796b94c00005235 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P04637 TP53 Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005541 GO:0003700 DNA-binding transcription factor activity GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0000785 chromatin false UniProtKB:Q00987 MDM2 Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005559 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13315 ATM Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005571 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:Q13315 ATM Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005582 GO:0004674 protein serine/threonine kinase activity GO:0050821 protein stabilization false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005592 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6796b94c00005540 MDM2 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage, promoting signal transduction by TP53/p53 (Human). NCBITaxon:9606 gomodel:6796b94c00005540/6796b94c00005610 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q12834 CDC20 Hsap 6796b94c00006015 FBXO31 is ubiquitinated and degraded by the APC/C complex (Human). NCBITaxon:9606 gomodel:6796b94c00006015/6796b94c00006016 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031145 anaphase-promoting complex-dependent catabolic process false UniProtKB:Q9NYG5 ANAPC11 Hsap 6796b94c00006015 FBXO31 is ubiquitinated and degraded by the APC/C complex (Human). NCBITaxon:9606 gomodel:6796b94c00006015/6796b94c00006023 GO:0061630 ubiquitin protein ligase activity GO:0031145 anaphase-promoting complex-dependent catabolic process false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00006015 FBXO31 is ubiquitinated and degraded by the APC/C complex (Human). NCBITaxon:9606 gomodel:6796b94c00006015/6796b94c00006031 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P31749 AKT1 Hsap 6796b94c00006015 FBXO31 is ubiquitinated and degraded by the APC/C complex (Human). NCBITaxon:9606 gomodel:6796b94c00006015/6796b94c00006037 GO:0004674 protein serine/threonine kinase activity GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process false UniProtKB:O43318 MAP3K7 Hsap 6796b94c00006045 Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) NCBITaxon:9606 gomodel:6796b94c00006045/6796b94c00006198 GO:0004709 MAP kinase kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:P52564 MAP2K6 Hsap 6796b94c00006045 Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) NCBITaxon:9606 gomodel:6796b94c00006045/6796b94c00006211 GO:0004708 MAP kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q15759 MAPK11 Hsap 6796b94c00006045 Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) NCBITaxon:9606 gomodel:6796b94c00006045/6796b94c00006223 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q16539 MAPK14 Hsap 6796b94c00006045 Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) NCBITaxon:9606 gomodel:6796b94c00006045/6796b94c00006232 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:A0A0N9NCU6 yopJ NCBITaxon:633 6796b94c00006045 Yersinia YopJ inhibits the MAPK cascade by mediating acetylation of MAP2K6, preventing phosphorylation and activation of MAP2K6 (Y.pseudotuberculosis and Human) NCBITaxon:9606 gomodel:6796b94c00006045/6796b94c00006242 GO:0016413 O-acetyltransferase activity GO:0141070 symbiont-mediated suppression of host MAPK cascade false UniProtKB:O43318 MAP3K7 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006252 GO:0004709 MAP kinase kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:P52564 MAP2K6 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006261 GO:0004708 MAP kinase kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q15759 MAPK11 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006273 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q16539 MAPK14 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006282 GO:0004707 MAP kinase activity GO:0038066 p38MAPK cascade GO:0005829 cytosol false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006302 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6796b94c00006250 MAP2K6 is ubiquitinated and degraded by the SCF(FBXO31) complex following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006250/6796b94c00006311 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q13315 ATM Hsap 6796b94c00006325 The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006325/6796b94c00006344 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response false UniProtKB:Q13315 ATM Hsap 6796b94c00006325 The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006325/6796b94c00006351 GO:0004674 protein serine/threonine kinase activity GO:0050821 protein stabilization false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00006325 The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006325/6796b94c00006360 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 6796b94c00006325 The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006325/6796b94c00006371 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q6PJ61 FBXO46 Hsap 6796b94c00006325 The SCF(FBXO31) complex mediates ubiquitination and degradation of FBXO46 following DNA damage (Human). NCBITaxon:9606 gomodel:6796b94c00006325/6796b94c00006384 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P42345 MTOR Hsap 6796b94c00006392 The SCF(FBXO46) complex mediates ubiquitination and degradation of FBXO31 in absence of stress (Human). NCBITaxon:9606 gomodel:6796b94c00006392/6796b94c00006394 GO:0004674 protein serine/threonine kinase activity GO:0062027 positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process false UniProtKB:Q6PJ61 FBXO46 Hsap 6796b94c00006392 The SCF(FBXO46) complex mediates ubiquitination and degradation of FBXO31 in absence of stress (Human). NCBITaxon:9606 gomodel:6796b94c00006392/6796b94c00006410 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6796b94c00006392 The SCF(FBXO46) complex mediates ubiquitination and degradation of FBXO31 in absence of stress (Human). NCBITaxon:9606 gomodel:6796b94c00006392/6796b94c00006421 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q5XUX0 FBXO31 Hsap 6796b94c00006392 The SCF(FBXO46) complex mediates ubiquitination and degradation of FBXO31 in absence of stress (Human). NCBITaxon:9606 gomodel:6796b94c00006392/6796b94c00006433 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P49841 GSK3B Hsap 67b1629100000368 Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) NCBITaxon:9606 gomodel:67b1629100000368/67b1629100000369 GO:0004674 protein serine/threonine kinase activity GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q969H0 FBXW7 Hsap 67b1629100000368 Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) NCBITaxon:9606 gomodel:67b1629100000368/67b1629100000378 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 67b1629100000368 Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) NCBITaxon:9606 gomodel:67b1629100000368/67b1629100000389 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q08050 FOXM1 Hsap 67b1629100000368 Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) NCBITaxon:9606 gomodel:67b1629100000368/67b1629100000434 GO:0003700 DNA-binding transcription factor activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P45974 USP5 Hsap 67b1629100000368 Inhibition of FBXW7 by USP5 to prevent FOXM1 degradation (Human) NCBITaxon:9606 gomodel:67b1629100000368/67b1629100000442 GO:0004843 cysteine-type deubiquitinase activity GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q6QNK2 ADGRD1 Hsap 67b1629100000802 "ADGRD1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by 5alpha-dihydrotestosterone (Human)." NCBITaxon:9606 gomodel:67b1629100000802/67b1629100000803 GO:0004930 G protein-coupled receptor activity GO:0014819 regulation of skeletal muscle contraction GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67b1629100000802 "ADGRD1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by 5alpha-dihydrotestosterone (Human)." NCBITaxon:9606 gomodel:67b1629100000802/67b1629100000805 GO:0003925 G protein activity GO:0014819 regulation of skeletal muscle contraction GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100000802 "ADGRD1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by 5alpha-dihydrotestosterone (Human)." NCBITaxon:9606 gomodel:67b1629100000802/67b1629100000807 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q15116 PDCD1 Hsap 67b1629100000848 The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:67b1629100000848/67b1629100000879 GO:0038023 signaling receptor activity GO:0002841 negative regulation of T cell mediated immune response to tumor cell GO:0005886 plasma membrane false UniProtKB:Q9NZQ7 CD274 Hsap 67b1629100000848 The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:67b1629100000848/67b1629100000886 GO:0048018 receptor ligand activity GO:0002841 negative regulation of T cell mediated immune response to tumor cell GO:0005886 plasma membrane false UniProtKB:Q6PIJ6 FBXO38 Hsap 67b1629100000848 The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:67b1629100000848/67b1629100000914 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P27361 MAPK3 Hsap 67b1629100000848 The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:67b1629100000848/67b1629100000926 GO:0004674 protein serine/threonine kinase activity GO:0002841 negative regulation of T cell mediated immune response to tumor cell GO:0005737 cytoplasm false UniProtKB:P45974 USP5 Hsap 67b1629100000848 The ERK1/USP5 axis deubiquitinates and stabilizes PDCD1/PD-1 (Human). NCBITaxon:9606 gomodel:67b1629100000848/67b1629100000934 GO:0101005 deubiquitinase activity GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8IZP9 ADGRG2 Hsap 67b1629100001260 "ADGRG2-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dehydroepiandrosterone (Human)." NCBITaxon:9606 gomodel:67b1629100001260/67b1629100001261 GO:0004930 G protein-coupled receptor activity GO:0007286 spermatid development GO:0016324 apical plasma membrane false UniProtKB:P63092 GNAS Hsap 67b1629100001260 "ADGRG2-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dehydroepiandrosterone (Human)." NCBITaxon:9606 gomodel:67b1629100001260/67b1629100001263 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100001260 "ADGRG2-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dehydroepiandrosterone (Human)." NCBITaxon:9606 gomodel:67b1629100001260/67b1629100001265 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q86Y34 ADGRG3 Hsap 67b1629100001304 ADGRG3-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by cortisol (Human). NCBITaxon:9606 gomodel:67b1629100001304/67b1629100001305 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100001304 ADGRG3-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by cortisol (Human). NCBITaxon:9606 gomodel:67b1629100001304/67b1629100001306 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67b1629100001304 ADGRG3-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by cortisol (Human). NCBITaxon:9606 gomodel:67b1629100001304/67b1629100001307 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P45974 USP5 Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001922 GO:0101005 deubiquitinase activity GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8N3Y1 FBXW8 Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001929 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001936 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9BYJ9 YTHDF1 Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001943 GO:1990247 N6-methyladenosine-containing RNA reader activity GO:0045727 positive regulation of translation GO:0005737 cytoplasm false UniProtKB:P01308 INS Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001950 GO:0005179 hormone activity GO:0008286 insulin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P42345 MTOR Hsap 67b1629100001426 USP5 deubiquitnation of YTHDF1 after activation by insulin-MTOR axis (Human) NCBITaxon:9606 gomodel:67b1629100001426/67b1629100001957 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005737 cytoplasm false UniProtKB:P22059 OSBP Hsap 67b1629100001527 Lipid transport activity of OSBP (Human) NCBITaxon:9606 gomodel:67b1629100001527/67b1629100001531 GO:0160291 phosphatidylinositol-4-phosphate-cholesterol exchange activity GO:0006869 lipid transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q9UJA2 CRLS1 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002093 GO:0043337 cardiolipin synthase (CMP-forming) activity GO:0032049 cardiolipin biosynthetic process GO:0031966 mitochondrial membrane false UniProtKB:Q8WUK0 PTPMT1 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002097 GO:0008962 phosphatidylglycerophosphatase activity GO:0032049 cardiolipin biosynthetic process GO:0005739 mitochondrion false UniProtKB:Q32NB8 PGS1 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002101 GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity GO:0032049 cardiolipin biosynthetic process GO:0005759 mitochondrial matrix false UniProtKB:Q96BW9 TAMM41 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002105 GO:0004605 phosphatidate cytidylyltransferase activity GO:0016024 CDP-diacylglycerol biosynthetic process GO:0005759 mitochondrial matrix false UniProtKB:Q8TC71 SPATA18 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002114 GO:0140693 molecular condensate scaffold activity GO:1900210 positive regulation of cardiolipin metabolic process GO:0005759 mitochondrial matrix false UniProtKB:O60733 PLA2G6 Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002132 GO:0004623 A2-type glycerophospholipase activity GO:0035965 cardiolipin acyl-chain remodeling GO:0005739 mitochondrion false UniProtKB:P40939 HADHA Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002145 GO:0052816 long-chain fatty acyl-CoA hydrolase activity GO:0035965 cardiolipin acyl-chain remodeling GO:0005743 mitochondrial inner membrane false UniProtKB:Q16635 TAFAZZIN Hsap 67b1629100002092 Cardiolipin metabolic process (GO:0032048) (Human) NCBITaxon:9606 gomodel:67b1629100002092/67b1629100002152 GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups GO:0035965 cardiolipin acyl-chain remodeling GO:0005739 mitochondrion false UniProtKB:O95970 LGI1 Hsap 67b1629100002554 LGI1-ADAM22 pair functions in synaptic transmission (Human) NCBITaxon:9606 gomodel:67b1629100002554/67b1629100002555 GO:0048018 receptor ligand activity GO:0050806 positive regulation of synaptic transmission GO:0005576 extracellular region false UniProtKB:Q9P0K1 ADAM22 Hsap 67b1629100002554 LGI1-ADAM22 pair functions in synaptic transmission (Human) NCBITaxon:9606 gomodel:67b1629100002554/67b1629100002562 GO:0038023 signaling receptor activity GO:0050806 positive regulation of synaptic transmission GO:0005886 plasma membrane false UniProtKB:P78352 DLG4 Hsap 67b1629100002554 LGI1-ADAM22 pair functions in synaptic transmission (Human) NCBITaxon:9606 gomodel:67b1629100002554/67b1629100002572 GO:0030674 protein-macromolecule adaptor activity GO:0050806 positive regulation of synaptic transmission GO:0005737 cytoplasm false UniProtKB:Q9Y653 ADGRG1 Hsap 67b1629100002643 ADGRG1-mediated signaling via G-alpha-13activating RhoA following activation by 17alpha-hydroxypregnenolone (Human). NCBITaxon:9606 gomodel:67b1629100002643/67b1629100002645 GO:0004930 G protein-coupled receptor activity GO:0110076 negative regulation of ferroptosis GO:0005886 plasma membrane false UniProtKB:Q14344 GNA13 Hsap 67b1629100002643 ADGRG1-mediated signaling via G-alpha-13activating RhoA following activation by 17alpha-hydroxypregnenolone (Human). NCBITaxon:9606 gomodel:67b1629100002643/67b1629100002652 GO:0003925 G protein activity GO:0160221 Rho-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9NZN5 ARHGEF12 Hsap 67b1629100002643 ADGRG1-mediated signaling via G-alpha-13activating RhoA following activation by 17alpha-hydroxypregnenolone (Human). NCBITaxon:9606 gomodel:67b1629100002643/67b1629100002661 GO:0005085 guanyl-nucleotide exchange factor activity GO:0160221 Rho-activating G protein-coupled receptor signaling pathway false UniProtKB:P61586 RHOA Hsap 67b1629100002643 ADGRG1-mediated signaling via G-alpha-13activating RhoA following activation by 17alpha-hydroxypregnenolone (Human). NCBITaxon:9606 gomodel:67b1629100002643/67b1629100002669 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:P36896 ACVR1B Hsap 67b1629100002705 Activin A signaling pathway (Human) NCBITaxon:9606 gomodel:67b1629100002705/67b1629100002706 GO:0016361 activin receptor activity, type I GO:0032924 activin receptor signaling pathway GO:0005886 plasma membrane false GO:0043509 activin A complex 67b1629100002705 Activin A signaling pathway (Human) NCBITaxon:9606 gomodel:67b1629100002705/67b1629100002713 GO:0005125 cytokine activity GO:0032924 activin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P27037 ACVR2A Hsap 67b1629100002705 Activin A signaling pathway (Human) NCBITaxon:9606 gomodel:67b1629100002705/67b1629100002733 GO:0016362 activin receptor activity, type II GO:0032924 activin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15796 SMAD2 Hsap 67b1629100002705 Activin A signaling pathway (Human) NCBITaxon:9606 gomodel:67b1629100002705/67b1629100002754 GO:0003700 DNA-binding transcription factor activity GO:0032924 activin receptor signaling pathway GO:0005634 nucleus false UniProtKB:P84022 SMAD3 Hsap 67b1629100002705 Activin A signaling pathway (Human) NCBITaxon:9606 gomodel:67b1629100002705/67b1629100002762 GO:0003700 DNA-binding transcription factor activity GO:0032924 activin receptor signaling pathway GO:0005634 nucleus false UniProtKB:Q5T601 ADGRF1 Hsap 67b1629100003101 "ADGRF1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by N-docosahexaenoylethanolamine (synaptamide) (Human)." NCBITaxon:9606 gomodel:67b1629100003101/67b1629100003102 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67b1629100003101 "ADGRF1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by N-docosahexaenoylethanolamine (synaptamide) (Human)." NCBITaxon:9606 gomodel:67b1629100003101/67b1629100003104 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100003101 "ADGRF1-mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by N-docosahexaenoylethanolamine (synaptamide) (Human)." NCBITaxon:9606 gomodel:67b1629100003101/67b1629100003106 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P56962 STX17 Hsap 67b1629100003158 RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) NCBITaxon:9606 gomodel:67b1629100003158/67b1629100003167 GO:0005484 SNAP receptor activity GO:0061909 autophagosome-lysosome fusion GO:0000421 autophagosome membrane false GO:0030897 HOPS complex 67b1629100003158 RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) NCBITaxon:9606 gomodel:67b1629100003158/67b1629100003195 GO:0060090 molecular adaptor activity GO:0061909 autophagosome-lysosome fusion GO:0005765 lysosomal membrane false UniProtKB:Q14964 RAB39A Hsap 67b1629100003158 RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) NCBITaxon:9606 gomodel:67b1629100003158/67b1629100003202 GO:0003925 G protein activity GO:0061909 autophagosome-lysosome fusion GO:0005765 lysosomal membrane false UniProtKB:P61019 RAB2A Hsap 67b1629100003158 RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) NCBITaxon:9606 gomodel:67b1629100003158/67b1629100003208 GO:0003925 G protein activity GO:0061909 autophagosome-lysosome fusion GO:0000421 autophagosome membrane false UniProtKB:Q96LT7 C9orf72 Hsap 67b1629100003158 RAB39A and RAB2A-induced HOPS-mediated autophagosome-lysosome fusion (Human) NCBITaxon:9606 gomodel:67b1629100003158/67b1629100003213 GO:0005085 guanyl-nucleotide exchange factor activity GO:0043087 regulation of GTPase activity GO:0005829 cytosol false UniProtKB:Q86SQ4 ADGRG6 Hsap 67b1629100003698 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by 17alpha-hydroxyprogesterone (Human). NCBITaxon:9606 gomodel:67b1629100003698/67b1629100003699 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100003698 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by 17alpha-hydroxyprogesterone (Human). NCBITaxon:9606 gomodel:67b1629100003698/67b1629100003700 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67b1629100003698 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by 17alpha-hydroxyprogesterone (Human). NCBITaxon:9606 gomodel:67b1629100003698/67b1629100003701 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q86SQ4 ADGRG6 Hsap 67b1629100003733 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by progesterone (Human). NCBITaxon:9606 gomodel:67b1629100003733/67b1629100003734 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67b1629100003733 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by progesterone (Human). NCBITaxon:9606 gomodel:67b1629100003733/67b1629100003735 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67b1629100003733 ADGRG6-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by progesterone (Human). NCBITaxon:9606 gomodel:67b1629100003733/67b1629100003736 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P15538 CYP11B1 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003775 GO:0004507 steroid 11-beta-monooxygenase activity GO:0034651 cortisol biosynthetic process GO:0005743 mitochondrial inner membrane true adrenal_steroidogenesis UniProtKB:P08686 CYP21A2 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003786 GO:0103069 17-hydroxyprogesterone 21-hydroxylase activity GO:0034651 cortisol biosynthetic process true adrenal_steroidogenesis UniProtKB:P05093 CYP17A1 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003794 GO:0004508 steroid 17-alpha-monooxygenase activity GO:0034651 cortisol biosynthetic process true adrenal_steroidogenesis UniProtKB:P14060 HSD3B1 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003802 GO:0003854 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity GO:0006701 progesterone biosynthetic process false UniProtKB:P14060 HSD3B1 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003811 GO:0004769 steroid Delta-isomerase activity GO:0006701 progesterone biosynthetic process false UniProtKB:P05108 CYP11A1 Hsap 67b1629100003765 Progesterone and cortisol biosynthetic pathway from cholesterol (Human). NCBITaxon:9606 gomodel:67b1629100003765/67b1629100003818 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity GO:0120178 steroid hormone biosynthetic process true adrenal_steroidogenesis UniProtKB:P24928 POLR2A Hsap 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100003857 GO:0003899 DNA-directed RNA polymerase activity GO:0006368 transcription elongation by RNA polymerase II GO:0005694 chromosome false UniProtKB:P50613 CDK7 Hsap 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100003869 GO:0140836 RNA polymerase II CTD heptapeptide repeat S5 kinase activity GO:0006367 transcription initiation at RNA polymerase II promoter GO:0005634 nucleus false UniProtKB:Q96C12 ARMC5 Hsap 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100003978 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0000785 chromatin false UniProtKB:P62877 RBX1 Hsap 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100003990 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13618 CUL3 Hsap 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100004001 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false GO:0032044 DSIF complex 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100004259 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false GO:0032021 NELF complex 67b1629100003856 ARMC5 mediates RNA polymerase II transcription initiation surveillance by mediating ubiquitination and degradation of POLR2A (Human). NCBITaxon:9606 gomodel:67b1629100003856/67b1629100004271 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false UniProtKB:P24928 POLR2A Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004024 GO:0003899 DNA-directed RNA polymerase activity GO:0006368 transcription elongation by RNA polymerase II GO:0005694 chromosome false UniProtKB:P50613 CDK7 Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004034 GO:0140836 RNA polymerase II CTD heptapeptide repeat S5 kinase activity GO:0006367 transcription initiation at RNA polymerase II promoter GO:0005634 nucleus false UniProtKB:P67775 PPP2CA Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004092 GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0160240 RNA polymerase II transcription initiation surveillance GO:0000785 chromatin false UniProtKB:P67775 PPP2CA Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004101 GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0160240 RNA polymerase II transcription initiation surveillance GO:0000785 chromatin false UniProtKB:P67775 PPP2CA Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004110 GO:0180008 RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0160240 RNA polymerase II transcription initiation surveillance GO:0000785 chromatin false UniProtKB:P30153 PPP2R1A Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004119 GO:0019888 protein phosphatase regulator activity GO:0160240 RNA polymerase II transcription initiation surveillance GO:0000785 chromatin false UniProtKB:Q9UL03 INTS6 Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004144 GO:0030674 protein-macromolecule adaptor activity GO:0160240 RNA polymerase II transcription initiation surveillance GO:0000785 chromatin false UniProtKB:Q5TA45 INTS11 Hsap 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004163 GO:0004521 RNA endonuclease activity GO:0160240 RNA polymerase II transcription initiation surveillance false GO:0032044 DSIF complex 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004182 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false GO:0032021 NELF complex 67b1629100004023 The INTAC complex mediates RNA polymerase II transcription initiation surveillance by catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A and degrading the exiting nascent RNA transcript (Human). NCBITaxon:9606 gomodel:67b1629100004023/67b1629100004193 GO:0140870 RNA polymerase inhibitor activity GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q9UGM1 CHRNA9 Hsap 67b1629100004130 CHRNA9 nAChR potassium channel activity. (Human) NCBITaxon:9606 gomodel:67b1629100004130/67b1629100004134 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UGM1 CHRNA9 Hsap 67b1629100004300 CHRNA9 nAChR sodium channel activity. (Human) NCBITaxon:9606 gomodel:67b1629100004300/67b1629100004304 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UGM1 CHRNA9 Hsap 67b1629100004322 CHRNA9 nAChR calcium channel activity. (Human) NCBITaxon:9606 gomodel:67b1629100004322/67b1629100004326 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005886 plasma membrane false GO:0005892 acetylcholine-gated channel complex 67b1629100004393 (CHRNA10)3:(CHRNA9)2 nAChR activated by acetylcholine. (Human) NCBITaxon:9606 gomodel:67b1629100004393/67b1629100004394 GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity GO:0095500 acetylcholine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P46093 GPR4 Hsap 67c10cc400001727 "GPR4-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001727/67c10cc400001728 GO:0004930 G protein-coupled receptor activity GO:0071468 cellular response to acidic pH GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67c10cc400001727 "GPR4-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001727/67c10cc400001730 GO:0003925 G protein activity GO:0071468 cellular response to acidic pH GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400001727 "GPR4-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001727/67c10cc400001732 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q8IYL9 GPR65 Hsap 67c10cc400001765 "GPR65-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001765/67c10cc400001766 GO:0004930 G protein-coupled receptor activity GO:0071468 cellular response to acidic pH GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67c10cc400001765 "GPR65-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001765/67c10cc400001768 GO:0003925 G protein activity GO:0071468 cellular response to acidic pH GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400001765 "GPR65-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by protons (Human)." NCBITaxon:9606 gomodel:67c10cc400001765/67c10cc400001770 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q15743 GPR68 Hsap 67c10cc400001896 GPR68-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by protons (Human). NCBITaxon:9606 gomodel:67c10cc400001896/67c10cc400001897 GO:0004930 G protein-coupled receptor activity GO:0071468 cellular response to acidic pH GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 67c10cc400001896 GPR68-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by protons (Human). NCBITaxon:9606 gomodel:67c10cc400001896/67c10cc400001899 GO:0003925 G protein activity GO:0071468 cellular response to acidic pH GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 67c10cc400001896 GPR68-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by protons (Human). NCBITaxon:9606 gomodel:67c10cc400001896/67c10cc400001945 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9NZB8-5 MOCS1 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002722 GO:0061798 GTP 3',8'-cyclase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005759 mitochondrial matrix false UniProtKB:Q9NZB8 MOCS1 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002726 GO:0061799 cyclic pyranopterin monophosphate synthase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005759 mitochondrial matrix false UniProtKB:Q9Y697-2 NFS1 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002733 GO:0031071 cysteine desulfurase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:O95396 MOCS3 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002737 GO:0061604 molybdopterin-synthase sulfurtransferase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:Q9NQX3-1 GPHN Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002742 GO:0061598 molybdopterin adenylyltransferase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:Q9NQX3 GPHN Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002746 GO:0061599 molybdopterin molybdotransferase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:Q96EN8 MOCOS Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002753 GO:0008265 molybdenum cofactor sulfurtransferase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:O96007 MOCS2 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002779 GO:0030366 molybdopterin synthase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:O95396 MOCS3 Hsap 67c10cc400002721 Mo-molybdopterin cofactor biosynthetic process (Human) NCBITaxon:9606 gomodel:67c10cc400002721/67c10cc400002807 GO:0061605 molybdopterin-synthase adenylyltransferase activity GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005829 cytosol false UniProtKB:P41180 CASR Hsap 67c10cc400004342 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004342/67c10cc400004343 GO:0004930 G protein-coupled receptor activity GO:0006874 intracellular calcium ion homeostasis GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400004342 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004342/67c10cc400004344 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67c10cc400004342 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004342/67c10cc400004345 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P41180 CASR Hsap 67c10cc400004380 CASR-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004380/67c10cc400004381 GO:0004930 G protein-coupled receptor activity GO:0006874 intracellular calcium ion homeostasis GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 67c10cc400004380 CASR-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004380/67c10cc400004382 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 67c10cc400004380 CASR-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by extracellular calcium (Human). NCBITaxon:9606 gomodel:67c10cc400004380/67c10cc400004383 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P41180 CASR Hsap 67c10cc400004457 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) promotes assembly of the NLRP3 inflammasome (Human). NCBITaxon:9606 gomodel:67c10cc400004457/67c10cc400004458 GO:0004930 G protein-coupled receptor activity GO:0006874 intracellular calcium ion homeostasis GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400004457 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) promotes assembly of the NLRP3 inflammasome (Human). NCBITaxon:9606 gomodel:67c10cc400004457/67c10cc400004459 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67c10cc400004457 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) promotes assembly of the NLRP3 inflammasome (Human). NCBITaxon:9606 gomodel:67c10cc400004457/67c10cc400004460 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 67c10cc400004457 CASR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) promotes assembly of the NLRP3 inflammasome (Human). NCBITaxon:9606 gomodel:67c10cc400004457/67c10cc400004492 GO:0140299 molecular sensor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:Q03431 PTH1R Hsap 67c10cc400004508 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by parathyroid hormone (PTH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004508/67c10cc400004509 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67c10cc400004508 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by parathyroid hormone (PTH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004508/67c10cc400004511 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400004508 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by parathyroid hormone (PTH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004508/67c10cc400004513 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01270 PTH Hsap 67c10cc400004508 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by parathyroid hormone (PTH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004508/67c10cc400004538 GO:0005179 hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q03431 PTH1R Hsap 67c10cc400004549 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by Parathyroid hormone-related protein (PTHLH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004549/67c10cc400004550 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67c10cc400004549 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by Parathyroid hormone-related protein (PTHLH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004549/67c10cc400004552 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67c10cc400004549 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by Parathyroid hormone-related protein (PTHLH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004549/67c10cc400004554 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P12272 PTHLH Hsap 67c10cc400004549 "PTH1R-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by Parathyroid hormone-related protein (PTHLH) (Human)." NCBITaxon:9606 gomodel:67c10cc400004549/67c10cc400004576 GO:0005179 hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:O15084 ANKRD28 Hsap 67c10cc400004816 The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004816/67c10cc400004817 GO:0019888 protein phosphatase regulator activity GO:0051894 positive regulation of focal adhesion assembly GO:0030027 lamellipodium false UniProtKB:Q96S21 RAB40C Hsap 67c10cc400004816 The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004816/67c10cc400004836 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0000139 Golgi membrane false UniProtKB:Q93034 CUL5 Hsap 67c10cc400004816 The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004816/67c10cc400004848 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 67c10cc400004816 The ECS(RAB40C) complex mediates ubiquitination and degradation of ANKRD28 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004816/67c10cc400004856 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q7L0Q8 RHOU Hsap 67c10cc400004918 The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004918/67c10cc400004919 GO:0030674 protein-macromolecule adaptor activity GO:0120183 positive regulation of focal adhesion disassembly GO:0005925 focal adhesion false UniProtKB:Q8WXH6 RAB40A Hsap 67c10cc400004918 The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004918/67c10cc400004923 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q93034 CUL5 Hsap 67c10cc400004918 The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004918/67c10cc400004929 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 67c10cc400004918 The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004918/67c10cc400004933 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:O96013 PAK4 Hsap 67c10cc400004918 The ECS(RAB40A) complex mediates ubiquitination and degradation of RHOU during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400004918/67c10cc400004941 GO:0030674 protein-macromolecule adaptor activity GO:0050821 protein stabilization GO:0005737 cytoplasm false UniProtKB:O43306 ADCY6 Hsap 67c10cc400005003 GPR15/GPR15LG signaling via G-alpha-i (inhibiting adenylate cyclase (Human) NCBITaxon:9606 gomodel:67c10cc400005003/67c10cc400005005 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67c10cc400005003 GPR15/GPR15LG signaling via G-alpha-i (inhibiting adenylate cyclase (Human) NCBITaxon:9606 gomodel:67c10cc400005003/67c10cc400005006 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q6UWK7 GPR15LG Hsap 67c10cc400005003 GPR15/GPR15LG signaling via G-alpha-i (inhibiting adenylate cyclase (Human) NCBITaxon:9606 gomodel:67c10cc400005003/67c10cc400005036 GO:0048018 receptor ligand activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P49685 GPR15 Hsap 67c10cc400005003 GPR15/GPR15LG signaling via G-alpha-i (inhibiting adenylate cyclase (Human) NCBITaxon:9606 gomodel:67c10cc400005003/67c10cc400005043 GO:0004930 G protein-coupled receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6UWT2 ENHO Hsap 67c10cc400005105 Adropin-GPR19 axis regulating energy homeostasis (Human) NCBITaxon:9606 gomodel:67c10cc400005105/67c10cc400005109 GO:0005179 hormone activity GO:0097009 energy homeostasis GO:0005576 extracellular region false UniProtKB:Q15760 GPR19 Hsap 67c10cc400005105 Adropin-GPR19 axis regulating energy homeostasis (Human) NCBITaxon:9606 gomodel:67c10cc400005105/67c10cc400005116 GO:0004930 G protein-coupled receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P27361 MAPK3 Hsap 67c10cc400005105 Adropin-GPR19 axis regulating energy homeostasis (Human) NCBITaxon:9606 gomodel:67c10cc400005105/67c10cc400005127 GO:0004707 MAP kinase activity GO:0000165 MAPK cascade GO:0005737 cytoplasm false UniProtKB:Q16654 PDK4 Hsap 67c10cc400005105 Adropin-GPR19 axis regulating energy homeostasis (Human) NCBITaxon:9606 gomodel:67c10cc400005105/67c10cc400005135 GO:0004672 protein kinase activity GO:0042593 glucose homeostasis GO:0005739 mitochondrion false UniProtKB:P08559 PDHA1 Hsap 67c10cc400005105 Adropin-GPR19 axis regulating energy homeostasis (Human) NCBITaxon:9606 gomodel:67c10cc400005105/67c10cc400005311 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GO:0006006 glucose metabolic process GO:0005739 mitochondrion false UniProtKB:Q9H0J9 PARP12 Hsap 67c10cc400005330 PARP12 activated GOLGA1 activity toward E-cadherin (Human) NCBITaxon:9606 gomodel:67c10cc400005330/67c10cc400005331 GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity GO:0070633 transepithelial transport GO:0005802 trans-Golgi network false UniProtKB:Q15139 PRKD1 Hsap 67c10cc400005330 PARP12 activated GOLGA1 activity toward E-cadherin (Human) NCBITaxon:9606 gomodel:67c10cc400005330/67c10cc400005338 GO:0004674 protein serine/threonine kinase activity GO:0070633 transepithelial transport GO:0005802 trans-Golgi network false UniProtKB:Q92805 GOLGA1 Hsap 67c10cc400005330 PARP12 activated GOLGA1 activity toward E-cadherin (Human) NCBITaxon:9606 gomodel:67c10cc400005330/67c10cc400005357 GO:0140104 molecular carrier activity GO:0070633 transepithelial transport GO:0005802 trans-Golgi network false UniProtKB:P12830 CDH1 Hsap 67c10cc400005330 PARP12 activated GOLGA1 activity toward E-cadherin (Human) NCBITaxon:9606 gomodel:67c10cc400005330/67c10cc400005394 GO:0098631 cell adhesion mediator activity GO:0044331 cell-cell adhesion mediated by cadherin GO:0005886 plasma membrane false UniProtKB:P00736 C1R Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400005672 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P00736-PRO_0000027579 C1R-Complement_C1r_subcomponent_light_chain Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400005683 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false GO:0062167 complement component C1q complex 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400005695 GO:0019864 IgG binding GO:0006958 complement activation, classical pathway GO:0106139 symbiont cell surface false UniProtKB:P09871-PRO_0000027588 C1S-Complement_C1s_subcomponent_light_chain Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400006155 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P09871-PRO_0000027588 C1S-Complement_C1s_subcomponent_light_chain Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400006166 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400006237 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400006542 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400008180 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400008191 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67c10cc400008203 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67e5e74400000049 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67c10cc400005671 The classical complement pathway (Human). NCBITaxon:9606 gomodel:67c10cc400005671/67e5e74400000059 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P03971 AMH Hsap 67c10cc400005742 AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400005742/67c10cc400005755 GO:0005179 hormone activity GO:1990262 anti-Mullerian hormone receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q16671 AMHR2 Hsap 67c10cc400005742 AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400005742/67c10cc400005762 GO:1990272 anti-Mullerian hormone receptor activity GO:1990262 anti-Mullerian hormone receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P36894 BMPR1A Hsap 67c10cc400005742 AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400005742/67c10cc400005795 GO:0005025 transforming growth factor beta receptor activity, type I GO:1990262 anti-Mullerian hormone receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15797 SMAD1 Hsap 67c10cc400005742 AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400005742/67c10cc400005807 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:1990262 anti-Mullerian hormone receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q99717 SMAD5 Hsap 67c10cc400005742 AMH-AMHR2 signaling leading to anti-mullerian signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400005742/67c10cc400005815 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:1990262 anti-Mullerian hormone receptor signaling pathway GO:0000785 chromatin false UniProtKB:Q9UHB6 LIMA1 Hsap 67c10cc400006997 The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400006997/67c10cc400006998 GO:0140778 microtubule stabilizing activity GO:0032233 positive regulation of actin filament bundle assembly GO:0030027 lamellipodium false UniProtKB:Q12829 RAB40B Hsap 67c10cc400006997 The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400006997/67c10cc400007002 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0030027 lamellipodium false UniProtKB:Q93034 CUL5 Hsap 67c10cc400006997 The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400006997/67c10cc400007008 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 67c10cc400006997 The ECS(RAB40B) complex mediates ubiquitination and degradation of LIMA1 during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400006997/67c10cc400007012 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P10114 RAP2A Hsap 67c10cc400007117 The ECS(RAB40B) complex mediates ubiquitination and degradation of RAP2A during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400007117/67c10cc400007118 GO:0003925 G protein activity GO:0030335 positive regulation of cell migration GO:0031258 lamellipodium membrane false UniProtKB:Q12829 RAB40B Hsap 67c10cc400007117 The ECS(RAB40B) complex mediates ubiquitination and degradation of RAP2A during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400007117/67c10cc400007122 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0016567 protein ubiquitination GO:0031258 lamellipodium membrane false UniProtKB:Q93034 CUL5 Hsap 67c10cc400007117 The ECS(RAB40B) complex mediates ubiquitination and degradation of RAP2A during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400007117/67c10cc400007128 GO:0160072 ubiquitin ligase complex scaffold activity GO:0016567 protein ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9UBF6 RNF7 Hsap 67c10cc400007117 The ECS(RAB40B) complex mediates ubiquitination and degradation of RAP2A during cell migration (Human) NCBITaxon:9606 gomodel:67c10cc400007117/67c10cc400007132 GO:0061630 ubiquitin protein ligase activity GO:0016567 protein ubiquitination GO:0005737 cytoplasm false UniProtKB:P61366 OSTN Hsap 67c10cc400007867 Role of NPR3 as receptor for OSTN (Human) NCBITaxon:9606 gomodel:67c10cc400007867/67c10cc400007868 GO:0005179 hormone activity GO:0098868 bone growth GO:0005576 extracellular region false UniProtKB:P17342 NPR3 Hsap 67c10cc400007867 Role of NPR3 as receptor for OSTN (Human) NCBITaxon:9606 gomodel:67c10cc400007867/67c10cc400007874 GO:0140319 receptor decoy activity GO:0033688 regulation of osteoblast proliferation GO:0005886 plasma membrane false UniProtKB:P16066 NPR1 Hsap 67c10cc400007867 Role of NPR3 as receptor for OSTN (Human) NCBITaxon:9606 gomodel:67c10cc400007867/67c10cc400007906 GO:0016941 natriuretic peptide receptor activity GO:0008217 regulation of blood pressure GO:0005886 plasma membrane false UniProtKB:P16860 NPPB Hsap 67c10cc400007867 Role of NPR3 as receptor for OSTN (Human) NCBITaxon:9606 gomodel:67c10cc400007867/6918f23700001015 GO:0005179 hormone activity GO:0008217 regulation of blood pressure GO:0005576 extracellular region false UniProtKB:P01160 NPPA Hsap 67c10cc400007867 Role of NPR3 as receptor for OSTN (Human) NCBITaxon:9606 gomodel:67c10cc400007867/6918f23700001024 GO:0005184 neuropeptide hormone activity GO:0008217 regulation of blood pressure GO:0005576 extracellular region false UniProtKB:P01133 EGF Hsap 67c10cc400009089 EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009089/67c10cc400009090 GO:0008083 growth factor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P00533 EGFR Hsap 67c10cc400009089 EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009089/67c10cc400009097 GO:0005006 epidermal growth factor receptor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 67c10cc400009089 EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009089/67c10cc400009104 GO:0030674 protein-macromolecule adaptor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q07889 SOS1 Hsap 67c10cc400009089 EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009089/67c10cc400009114 GO:0005085 guanyl-nucleotide exchange factor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P27361 MAPK3 Hsap 67c10cc400009089 EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009089/67c10cc400009122 GO:0004707 MAP kinase activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P00533 EGFR Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009146 GO:0005006 epidermal growth factor receptor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P62993 GRB2 Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009153 GO:0030674 protein-macromolecule adaptor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q07889 SOS1 Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009163 GO:0005085 guanyl-nucleotide exchange factor activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P27361 MAPK3 Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009171 GO:0004707 MAP kinase activity GO:0007173 epidermal growth factor receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9H6X2 ANTXR1 Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009187 GO:0038023 signaling receptor activity GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P00749 PLAU Hsap 67c10cc400009138 ANTXR1/PLAU interaction leading to activation of the EGF signaling pathway (Human) NCBITaxon:9606 gomodel:67c10cc400009138/67c10cc400009195 GO:0048018 receptor ligand activity GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000733 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000743 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000758 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000769 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000781 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000825 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000835 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P11226 MBL2 Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000846 GO:0038187 pattern recognition receptor activity GO:0001867 complement activation, lectin pathway GO:0106139 symbiont cell surface false UniProtKB:P48740 MASP1 Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000861 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P48740-PRO_0000027594 MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000872 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000889 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400000671 The lectin complement pathway following activation by MBL2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000671/67e5e74400000903 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400000920 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400000929 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400000943 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400000954 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400000966 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001004 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001014 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:O00602 FCN1 Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001025 GO:0038187 pattern recognition receptor activity GO:0001867 complement activation, lectin pathway GO:0106139 symbiont cell surface false UniProtKB:P48740 MASP1 Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001036 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P48740-PRO_0000027594 MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001047 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001064 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400000919 The lectin complement pathway following activation by FCN1 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400000919/67e5e74400001078 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001095 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001104 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001118 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001129 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001141 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001179 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001189 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:Q15485 FCN2 Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001200 GO:0038187 pattern recognition receptor activity GO:0001867 complement activation, lectin pathway GO:0106139 symbiont cell surface false UniProtKB:P48740 MASP1 Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001211 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P48740-PRO_0000027594 MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001222 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001239 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400001094 The lectin complement pathway following activation by FCN2 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001094/67e5e74400001253 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001270 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001279 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001293 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001304 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001316 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001354 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001364 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:O75636 FCN3 Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001375 GO:0038187 pattern recognition receptor activity GO:0001867 complement activation, lectin pathway GO:0106139 symbiont cell surface false UniProtKB:P48740 MASP1 Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001386 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P48740-PRO_0000027594 MASP1-Mannan-binding_lectin_serine_protease_1_light_chain Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001397 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001414 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:O00187-PRO_0000027600 MASP2-Mannan-binding_lectin_serine_protease_2_B_chain Hsap 67e5e74400001269 The lectin complement pathway following activation by FCN3 lectin (Human). NCBITaxon:9606 gomodel:67e5e74400001269/67e5e74400001428 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001701 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P00751-PRO_0000027547 CFB-Bb Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001712 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001724 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001768 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P00746 CFD Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001789 GO:0004252 serine-type endopeptidase activity GO:0006957 complement activation, alternative pathway GO:0005576 extracellular region false UniProtKB:P00751-PRO_0000027547 CFB-Bb Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001793 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P48740-2 MASP1 Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001860 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400001614 The alternative complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001614/67e5e74400001877 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:Q16663 CCL15 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002077 GO:0008009 chemokine activity GO:0050729 positive regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:P32246 CCR1 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002089 GO:0016493 C-C chemokine receptor activity GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:O95837 GNA14 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002110 GO:0003924 GTPase activity GO:0050729 positive regulation of inflammatory response GO:0005737 cytoplasm false UniProtKB:P40763 STAT3 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002125 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0050729 positive regulation of inflammatory response GO:0005634 nucleus false UniProtKB:Q99614 TTC1 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002141 GO:0030674 protein-macromolecule adaptor activity GO:0050729 positive regulation of inflammatory response GO:0005737 cytoplasm false UniProtKB:P05231 IL6 Hsap 67e5e74400001887 CCL15-CCR1 association leading to inflammatory response (Human) NCBITaxon:9606 gomodel:67e5e74400001887/67e5e74400002164 GO:0005125 cytokine activity GO:0006954 inflammatory response GO:0005576 extracellular region false UniProtKB:P49863 GZMK Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001926 GO:0004252 serine-type endopeptidase activity GO:0031638 zymogen activation GO:0106139 symbiont cell surface false UniProtKB:P0C0L4-PRO_0000005970 C4A-Complement_C4b-A Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001950 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001960 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P01024-PRO_0000005911 C3-Complement_C3b Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001975 GO:0003823 antigen binding GO:0008228 opsonization GO:0106139 symbiont cell surface false UniProtKB:P06681-PRO_0000027612 C2-Serine_protease_complement_C2b Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001986 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false GO:0005579 membrane attack complex 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400001998 GO:0022829 wide pore channel activity GO:0031640 killing of cells of another organism GO:0044218 other organism cell membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400002042 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400002052 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P49863 GZMK Hsap 67e5e74400001888 The GZMK complement pathway (Human). NCBITaxon:9606 gomodel:67e5e74400001888/67e5e74400002063 GO:0004252 serine-type endopeptidase activity GO:0051604 protein maturation GO:0106139 symbiont cell surface false UniProtKB:P13500 CCL2 Hsap 67e5e74400002539 CCL2-CCR2 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002539/67e5e74400002613 GO:0008009 chemokine activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P41597 CCR2 Hsap 67e5e74400002539 CCL2-CCR2 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002539/67e5e74400002620 GO:0016493 C-C chemokine receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 67e5e74400002539 CCL2-CCR2 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002539/67e5e74400002627 GO:0003924 GTPase activity GO:0070098 chemokine-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P13500 CCL2 Hsap 67e5e74400002640 CCL2-CCR3 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002640/67e5e74400002641 GO:0008009 chemokine activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P51677 CCR3 Hsap 67e5e74400002640 CCL2-CCR3 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002640/67e5e74400002648 GO:0016493 C-C chemokine receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 67e5e74400002640 CCL2-CCR3 signaling via GNAI1 (Human) NCBITaxon:9606 gomodel:67e5e74400002640/67e5e74400002655 GO:0003924 GTPase activity GO:0070098 chemokine-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P13501 CCL5 Hsap 67e5e74400002668 CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) NCBITaxon:9606 gomodel:67e5e74400002668/67e5e74400002979 GO:0042056 chemoattractant activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P32246 CCR1 Hsap 67e5e74400002668 CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) NCBITaxon:9606 gomodel:67e5e74400002668/67e5e74400002986 GO:0016493 C-C chemokine receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99614 TTC1 Hsap 67e5e74400002668 CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) NCBITaxon:9606 gomodel:67e5e74400002668/67e5e74400002993 GO:0030674 protein-macromolecule adaptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:P27361 MAPK3 Hsap 67e5e74400002668 CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) NCBITaxon:9606 gomodel:67e5e74400002668/67e5e74400002999 GO:0004707 MAP kinase activity GO:0150078 positive regulation of neuroinflammatory response GO:0005737 cytoplasm false UniProtKB:P28482 MAPK1 Hsap 67e5e74400002668 CCL5-CCR1 axis promotes neuroinflammation via ERK1/ERK2 (Human) NCBITaxon:9606 gomodel:67e5e74400002668/67e5e74400003005 GO:0004707 MAP kinase activity GO:0070098 chemokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O14920 IKBKB Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002821 GO:0008384 IkappaB kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002828 GO:0140311 protein sequestering activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002839 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002847 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:P80098 CCL7 Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002894 GO:0008009 chemokine activity GO:0050729 positive regulation of inflammatory response GO:0005576 extracellular region false UniProtKB:P32246 CCR1 Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002901 GO:0016493 C-C chemokine receptor activity GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:O43318 MAP3K7 Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002910 GO:0004707 MAP kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P01584 IL1B Hsap 67e5e74400002819 CCL7-CRR1 signaling leading to canonical NF-kappa activation in macrophages (Human). NCBITaxon:9606 gomodel:67e5e74400002819/67e5e74400002923 GO:0005125 cytokine activity GO:0006954 inflammatory response GO:0005576 extracellular region false UniProtKB:Q8N2A8 PLD6 Hsap 67e5e74400003200 PLD6-induced mitochondrial tethering through phosphatidic acid binding by NME3 (Human) NCBITaxon:9606 gomodel:67e5e74400003200/67e5e74400003201 GO:0035755 cardiolipin phospholipase D activity GO:0008654 phospholipid biosynthetic process GO:0005741 mitochondrial outer membrane false UniProtKB:Q13232 NME3 Hsap 67e5e74400003200 PLD6-induced mitochondrial tethering through phosphatidic acid binding by NME3 (Human) NCBITaxon:9606 gomodel:67e5e74400003200/67e5e74400003214 GO:0160204 mitochondrion-mitochondrion outer membrane tether activity GO:0008053 mitochondrial fusion GO:0005741 mitochondrial outer membrane false UniProtKB:P52799 EFNB2 Hsap 67e5e74400003294 EFNB2 ligand EPHB4 receptor in angiogenesis (Human) NCBITaxon:9606 gomodel:67e5e74400003294/67e5e74400003295 GO:0048018 receptor ligand activity GO:0001525 angiogenesis GO:0005886 plasma membrane false UniProtKB:P54760 EPHB4 Hsap 67e5e74400003294 EFNB2 ligand EPHB4 receptor in angiogenesis (Human) NCBITaxon:9606 gomodel:67e5e74400003294/67e5e74400003303 GO:0005003 ephrin receptor activity GO:0001525 angiogenesis GO:0005886 plasma membrane false UniProtKB:P20936 RASA1 Hsap 67e5e74400003294 EFNB2 ligand EPHB4 receptor in angiogenesis (Human) NCBITaxon:9606 gomodel:67e5e74400003294/67e5e74400003485 GO:0005096 GTPase activator activity GO:0048013 ephrin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P61073 CXCR4 Hsap 67e5e74400004191 CXCR4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by CXCL12/SDF-1 (Human). NCBITaxon:9606 gomodel:67e5e74400004191/67e5e74400004192 GO:0038147 C-X-C motif chemokine 12 receptor activity GO:0038160 CXCL12-activated CXCR4 signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67e5e74400004191 CXCR4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by CXCL12/SDF-1 (Human). NCBITaxon:9606 gomodel:67e5e74400004191/67e5e74400004193 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67e5e74400004191 CXCR4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by CXCL12/SDF-1 (Human). NCBITaxon:9606 gomodel:67e5e74400004191/67e5e74400004194 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P48061 CXCL12 Hsap 67e5e74400004191 CXCR4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by CXCL12/SDF-1 (Human). NCBITaxon:9606 gomodel:67e5e74400004191/67e5e74400004245 GO:0008009 chemokine activity GO:0038160 CXCL12-activated CXCR4 signaling pathway GO:0005576 extracellular region false UniProtKB:P30518 AVPR2 Hsap 67e5e74400004286 "AVPR2 -mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by vasopressin (AVP) (Human)." NCBITaxon:9606 gomodel:67e5e74400004286/67e5e74400004287 GO:0005000 vasopressin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 67e5e74400004286 "AVPR2 -mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by vasopressin (AVP) (Human)." NCBITaxon:9606 gomodel:67e5e74400004286/67e5e74400004289 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67e5e74400004286 "AVPR2 -mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by vasopressin (AVP) (Human)." NCBITaxon:9606 gomodel:67e5e74400004286/67e5e74400004291 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01185-PRO_0000020515 AVP-Arg-vasopressin Hsap 67e5e74400004286 "AVPR2 -mediated signaling G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by vasopressin (AVP) (Human)." NCBITaxon:9606 gomodel:67e5e74400004286/67e5e74400004322 GO:0005179 hormone activity GO:0070295 renal water absorption GO:0005576 extracellular region false UniProtKB:O95971 CD160 Hsap 67f85f2b00000459 HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:67f85f2b00000459/67f85f2b00000460 GO:0032393 MHC class I receptor activity GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P10321 HLA-C Hsap 67f85f2b00000459 HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:67f85f2b00000459/67f85f2b00000467 GO:0048018 receptor ligand activity GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0005576 extracellular region false UniProtKB:Q8NEB9 PIK3C3 Hsap 67f85f2b00000459 HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:67f85f2b00000459/67f85f2b00000477 GO:0052742 phosphatidylinositol kinase activity GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0005886 plasma membrane false UniProtKB:P05231 IL6 Hsap 67f85f2b00000459 HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:67f85f2b00000459/67f85f2b00000493 GO:0005125 cytokine activity GO:0070102 interleukin-6-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P01579 IFNG Hsap 67f85f2b00000459 HLA-C triggers CD160-mediated NK-cell cytotoxicity (Human) NCBITaxon:9606 gomodel:67f85f2b00000459/67f85f2b00000501 GO:0005125 cytokine activity GO:0060333 type II interferon-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q9UBU3 GHRL Hsap 67f85f2b00000823 Ghrelin-GHSR pair leading to G-alphaQ activation (Human) NCBITaxon:9606 gomodel:67f85f2b00000823/67f85f2b00000825 GO:0016608 growth hormone-releasing hormone activity GO:0009755 hormone-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q92847 GHSR Hsap 67f85f2b00000823 Ghrelin-GHSR pair leading to G-alphaQ activation (Human) NCBITaxon:9606 gomodel:67f85f2b00000823/67f85f2b00000832 GO:0016520 growth hormone-releasing hormone receptor activity GO:0009755 hormone-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P32121 ARRB2 Hsap 67f85f2b00000823 Ghrelin-GHSR pair leading to G-alphaQ activation (Human) NCBITaxon:9606 gomodel:67f85f2b00000823/67f85f2b00000839 GO:0030674 protein-macromolecule adaptor activity GO:0002031 G protein-coupled receptor internalization GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 67f85f2b00000823 Ghrelin-GHSR pair leading to G-alphaQ activation (Human) NCBITaxon:9606 gomodel:67f85f2b00000823/67f85f2b00000848 GO:0003925 G protein activity GO:0009755 hormone-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P15498 VAV1 Hsap 67f85f2b00001619 CD180-CD19 activation of B-cells by LPS (Human) NCBITaxon:9606 gomodel:67f85f2b00001619/67f85f2b00001620 GO:0005085 guanyl-nucleotide exchange factor activity GO:0042100 B cell proliferation GO:0005737 cytoplasm false UniProtKB:P07948 LYN Hsap 67f85f2b00001619 CD180-CD19 activation of B-cells by LPS (Human) NCBITaxon:9606 gomodel:67f85f2b00001619/67f85f2b00001626 GO:0004713 protein tyrosine kinase activity GO:0042100 B cell proliferation GO:0005737 cytoplasm false UniProtKB:P15391 CD19 Hsap 67f85f2b00001619 CD180-CD19 activation of B-cells by LPS (Human) NCBITaxon:9606 gomodel:67f85f2b00001619/67f85f2b00001632 GO:0015026 coreceptor activity GO:0042100 B cell proliferation GO:0005886 plasma membrane false UniProtKB:Q99467 CD180 Hsap 67f85f2b00001619 CD180-CD19 activation of B-cells by LPS (Human) NCBITaxon:9606 gomodel:67f85f2b00001619/67f85f2b00001638 GO:0001875 lipopolysaccharide immune receptor activity GO:0042100 B cell proliferation GO:0005886 plasma membrane false UniProtKB:P18089 ADRA2B Hsap 67f85f2b00003167 RAB43 ER-Golgi anterograde transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003167/67f85f2b00003168 GO:0004938 alpha2-adrenergic receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00003167 RAB43 ER-Golgi anterograde transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003167/67f85f2b00003169 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67f85f2b00003167 RAB43 ER-Golgi anterograde transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003167/67f85f2b00003170 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q86YS6 RAB43 Hsap 67f85f2b00003167 RAB43 ER-Golgi anterograde transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003167/67f85f2b00003200 GO:0003925 G protein activity GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport GO:0005789 endoplasmic reticulum membrane false UniProtKB:P08172 CHRM2 Hsap 67f85f2b00003584 CHRM2-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by acetylcholine (Human). NCBITaxon:9606 gomodel:67f85f2b00003584/67f85f2b00003585 GO:0016907 G protein-coupled acetylcholine receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00003584 CHRM2-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by acetylcholine (Human). NCBITaxon:9606 gomodel:67f85f2b00003584/67f85f2b00003586 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67f85f2b00003584 CHRM2-mediated signaling via G-alpha-o (inhibitory), inhibiting adenylate cyclase following activation by acetylcholine (Human). NCBITaxon:9606 gomodel:67f85f2b00003584/67f85f2b00003587 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P18089 ADRA2B Hsap 67f85f2b00003942 Signaling by noradrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00003942/67f85f2b00003943 GO:0004938 alpha2-adrenergic receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00003942 Signaling by noradrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00003942/67f85f2b00003944 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67f85f2b00003942 Signaling by noradrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00003942/67f85f2b00003945 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P18089 ADRA2B Hsap 67f85f2b00003986 RAB26 Golgi-to-cell membrane transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003986/67f85f2b00003987 GO:0004938 alpha2-adrenergic receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00003986 RAB26 Golgi-to-cell membrane transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003986/67f85f2b00003988 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67f85f2b00003986 RAB26 Golgi-to-cell membrane transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003986/67f85f2b00003989 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9ULW5 RAB26 Hsap 67f85f2b00003986 RAB26 Golgi-to-cell membrane transport of ADRA2B (Human) NCBITaxon:9606 gomodel:67f85f2b00003986/67f85f2b00004013 GO:0003925 G protein activity GO:0043001 Golgi to plasma membrane protein transport GO:0000139 Golgi membrane false UniProtKB:Q16581 C3AR1 Hsap 67f85f2b00004288 C3AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C3a (Human). NCBITaxon:9606 gomodel:67f85f2b00004288/67f85f2b00004289 GO:0004876 complement component C3a receptor activity GO:0002430 complement receptor mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00004288 C3AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C3a (Human). NCBITaxon:9606 gomodel:67f85f2b00004288/67f85f2b00004290 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67f85f2b00004288 C3AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C3a (Human). NCBITaxon:9606 gomodel:67f85f2b00004288/67f85f2b00004291 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01024-PRO_0000005910 C3-C3a_anaphylatoxin Hsap 67f85f2b00004288 C3AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C3a (Human). NCBITaxon:9606 gomodel:67f85f2b00004288/67f85f2b00004318 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P21730 C5AR1 Hsap 67f85f2b00004380 C5AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C5a (Human). NCBITaxon:9606 gomodel:67f85f2b00004380/67f85f2b00004381 GO:0004878 complement component C5a receptor activity GO:0002430 complement receptor mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00004380 C5AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C5a (Human). NCBITaxon:9606 gomodel:67f85f2b00004380/67f85f2b00004382 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 67f85f2b00004380 C5AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C5a (Human). NCBITaxon:9606 gomodel:67f85f2b00004380/67f85f2b00004383 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67f85f2b00004380 C5AR1-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by anaphylatoxin C5a (Human). NCBITaxon:9606 gomodel:67f85f2b00004380/67f85f2b00004410 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P21730 C5AR1 Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004427 GO:0004878 complement component C5a receptor activity GO:0002430 complement receptor mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P01031-PRO_0000005988 C5-C5a_anaphylatoxin Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004456 GO:0008009 chemokine activity GO:0030595 leukocyte chemotaxis GO:0005576 extracellular region false UniProtKB:P25098 GRK2 Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004469 GO:0004703 G protein-coupled receptor kinase activity GO:0002029 desensitization of G protein-coupled receptor signaling pathway false UniProtKB:P35626 GRK3 Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004492 GO:0004703 G protein-coupled receptor kinase activity GO:0002029 desensitization of G protein-coupled receptor signaling pathway false UniProtKB:P49407 ARRB1 Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004504 GO:0030674 protein-macromolecule adaptor activity GO:0002029 desensitization of G protein-coupled receptor signaling pathway false UniProtKB:P32121 ARRB2 Hsap 67f85f2b00004426 Desensitization of C5AR1-mediated signaling following phosphorylation by GRK2 or GRK3 (Human). NCBITaxon:9606 gomodel:67f85f2b00004426/67f85f2b00004511 GO:0030674 protein-macromolecule adaptor activity GO:0002029 desensitization of G protein-coupled receptor signaling pathway false UniProtKB:P08913 ADRA2A Hsap 67f85f2b00004554 Signaling by noradrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00004554/67f85f2b00004555 GO:0004938 alpha2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 67f85f2b00004554 Signaling by noradrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00004554/67f85f2b00004556 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 67f85f2b00004554 Signaling by noradrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:67f85f2b00004554/67f85f2b00004557 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O15417 TNRC18 Hsap 680ad14200000983 TNRC18 mediates silencing of endogenous retroviruses (ERV) by binding to H3K9me3 and mediating recruitment of Sin3-type complexes (Human). NCBITaxon:9606 gomodel:680ad14200000983/680ad14200000984 GO:0062072 histone H3K9me2/3 reader activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q15047 SETDB1 Hsap 680ad14200000983 TNRC18 mediates silencing of endogenous retroviruses (ERV) by binding to H3K9me3 and mediating recruitment of Sin3-type complexes (Human). NCBITaxon:9606 gomodel:680ad14200000983/680ad14200001003 GO:0140949 histone H3K9 trimethyltransferase activity GO:0141005 transposable element silencing by heterochromatin formation GO:0000785 chromatin false GO:0070822 Sin3-type complex 680ad14200000983 TNRC18 mediates silencing of endogenous retroviruses (ERV) by binding to H3K9me3 and mediating recruitment of Sin3-type complexes (Human). NCBITaxon:9606 gomodel:680ad14200000983/680ad14200001022 GO:0004407 histone deacetylase activity GO:0141005 transposable element silencing by heterochromatin formation GO:0000785 chromatin false UniProtKB:P18825 ADRA2C Hsap 680ad14200002493 Signaling by noradrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200002493/680ad14200002494 GO:0004938 alpha2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200002493 Signaling by noradrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200002493/680ad14200002495 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 680ad14200002493 Signaling by noradrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200002493/680ad14200002496 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O00155 GPR25 Hsap 680ad14200002702 GPR25 G protein-coupled receptor signaling following activation by CXCL17 (Human). NCBITaxon:9606 gomodel:680ad14200002702/680ad14200002704 GO:0004930 G protein-coupled receptor activity GO:0048247 lymphocyte chemotaxis GO:0005886 plasma membrane false UniProtKB:P61586 RHOA Hsap 680ad14200002702 GPR25 G protein-coupled receptor signaling following activation by CXCL17 (Human). NCBITaxon:9606 gomodel:680ad14200002702/680ad14200002728 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:Q6UXB2 CXCL17 Hsap 680ad14200002702 GPR25 G protein-coupled receptor signaling following activation by CXCL17 (Human). NCBITaxon:9606 gomodel:680ad14200002702/680ad14200002743 GO:0008009 chemokine activity GO:0048247 lymphocyte chemotaxis GO:0005576 extracellular region false UniProtKB:Q9HC97 GPR35 Hsap 680ad14200002791 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). NCBITaxon:9606 gomodel:680ad14200002791/680ad14200002792 GO:0004930 G protein-coupled receptor activity GO:0030593 neutrophil chemotaxis GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200002791 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). NCBITaxon:9606 gomodel:680ad14200002791/680ad14200002793 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200002791 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). NCBITaxon:9606 gomodel:680ad14200002791/680ad14200002794 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P49189 ALDH9A1 Hsap 680ad14200002791 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). NCBITaxon:9606 gomodel:680ad14200002791/680ad14200002839 GO:0004029 aldehyde dehydrogenase (NAD+) activity GO:0042429 serotonin catabolic process false UniProtKB:P21397-1 MAOA Hsap 680ad14200002791 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) (Human). NCBITaxon:9606 gomodel:680ad14200002791/680ad14200002849 GO:0008131 primary methylamine oxidase activity GO:0042429 serotonin catabolic process false UniProtKB:Q9HC97 GPR35 Hsap 680ad14200002857 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by Kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002857/680ad14200002858 GO:0004930 G protein-coupled receptor activity GO:0002548 monocyte chemotaxis GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200002857 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by Kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002857/680ad14200002859 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200002857 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by Kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002857/680ad14200002860 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9HC97 GPR35 Hsap 680ad14200002936 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by lysophosphatidic acid (Human). NCBITaxon:9606 gomodel:680ad14200002936/680ad14200002937 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200002936 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by lysophosphatidic acid (Human). NCBITaxon:9606 gomodel:680ad14200002936/680ad14200002938 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200002936 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by lysophosphatidic acid (Human). NCBITaxon:9606 gomodel:680ad14200002936/680ad14200002939 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9HC97 GPR35 Hsap 680ad14200002972 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002972/680ad14200002973 GO:0004930 G protein-coupled receptor activity GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0005886 plasma membrane false UniProtKB:Q96PN6 ADCY10 Hsap 680ad14200002972 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002972/680ad14200002974 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005739 mitochondrion false UniProtKB:P63096 GNAI1 Hsap 680ad14200002972 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002972/680ad14200002975 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9UII2 ATP5IF1 Hsap 680ad14200002972 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002972/680ad14200003011 GO:0042030 ATPase inhibitor activity GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0005739 mitochondrion false GO:0045259 proton-transporting ATP synthase complex 680ad14200002972 GPR35-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase promotes cardioprotection during ischemia following activation by kynurenic acid (Human). NCBITaxon:9606 gomodel:680ad14200002972/680ad14200003021 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0015986 proton motive force-driven ATP synthesis GO:0005743 mitochondrial inner membrane false UniProtKB:P18825 ADRA2C Hsap 680ad14200003082 Signaling by adrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003082/680ad14200003083 GO:0004938 alpha2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200003082 Signaling by adrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003082/680ad14200003084 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 680ad14200003082 Signaling by adrenaline mediated by ADRA2C receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003082/680ad14200003085 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P08913 ADRA2A Hsap 680ad14200003112 Signaling by adrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003112/680ad14200003113 GO:0004938 alpha2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200003112 Signaling by adrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003112/680ad14200003114 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 680ad14200003112 Signaling by adrenaline mediated by ADRA2A receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003112/680ad14200003115 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P18089 ADRA2B Hsap 680ad14200003143 Signaling by adrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003143/680ad14200003144 GO:0004938 alpha2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200003143 Signaling by adrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003143/680ad14200003145 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 680ad14200003143 Signaling by adrenaline mediated by ADRA2B receptor via G-alpha-o (inhibitory) (Human) NCBITaxon:9606 gomodel:680ad14200003143/680ad14200003146 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P08588 ADRB1 Hsap 680ad14200003171 Signaling by adrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003171/680ad14200003172 GO:0004940 beta1-adrenergic receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200003171 Signaling by adrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003171/680ad14200003174 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200003171 Signaling by adrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003171/680ad14200003176 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P08588 ADRB1 Hsap 680ad14200003271 Signaling by noradrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003271/680ad14200003272 GO:0004940 beta1-adrenergic receptor activity GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200003271 Signaling by noradrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003271/680ad14200003274 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200003271 Signaling by noradrenaline mediated by ADRB1 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:680ad14200003271/680ad14200003276 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9NS39 ADARB2 Hsap 680ad14200003421 Inhibition of ADARB1-mediated RNA editing by ADARB2/ADAR3 (Human). NCBITaxon:9606 gomodel:680ad14200003421/680ad14200003434 GO:0140610 RNA sequestering activity GO:0090367 negative regulation of mRNA modification GO:0005730 nucleolus false UniProtKB:P78563 ADARB1 Hsap 680ad14200003421 Inhibition of ADARB1-mediated RNA editing by ADARB2/ADAR3 (Human). NCBITaxon:9606 gomodel:680ad14200003421/680ad14200003439 GO:0003726 double-stranded RNA adenosine deaminase activity GO:0016556 mRNA modification GO:0005730 nucleolus false UniProtKB:P42262 GRIA2 Hsap 680ad14200003421 Inhibition of ADARB1-mediated RNA editing by ADARB2/ADAR3 (Human). NCBITaxon:9606 gomodel:680ad14200003421/680ad14200004434 GO:0004970 glutamate-gated receptor activity GO:0035249 synaptic transmission, glutamatergic GO:0098839 postsynaptic density membrane false UniProtKB:Q9UBZ9 REV1 Hsap 680ad14200003422 Translesion synthesis (TLS) involving REV1-MAD2L2 (HUMAN) NCBITaxon:9606 gomodel:680ad14200003422/680ad14200003447 GO:0030674 protein-macromolecule adaptor activity GO:0019985 translesion synthesis GO:0090734 site of DNA damage false UniProtKB:Q9UI95 MAD2L2 Hsap 680ad14200003422 Translesion synthesis (TLS) involving REV1-MAD2L2 (HUMAN) NCBITaxon:9606 gomodel:680ad14200003422/680ad14200003522 GO:0030674 protein-macromolecule adaptor activity GO:0019985 translesion synthesis GO:0090734 site of DNA damage false UniProtKB:O60673 REV3L Hsap 680ad14200003422 Translesion synthesis (TLS) involving REV1-MAD2L2 (HUMAN) NCBITaxon:9606 gomodel:680ad14200003422/680ad14200003577 GO:0003887 DNA-directed DNA polymerase activity GO:0071897 DNA biosynthetic process GO:0090734 site of DNA damage false UniProtKB:Q9BRQ8 AIFM2 Hsap 680ad14200003459 ALDH7A1 protects against ferroptosis by generating membrane NADH, thereby supporting AIFM2 activity (Human). NCBITaxon:9606 gomodel:680ad14200003459/680ad14200003460 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0110076 negative regulation of ferroptosis GO:0005886 plasma membrane false UniProtKB:P49419-2 ALDH7A1 Hsap 680ad14200003459 ALDH7A1 protects against ferroptosis by generating membrane NADH, thereby supporting AIFM2 activity (Human). NCBITaxon:9606 gomodel:680ad14200003459/680ad14200003472 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0110076 negative regulation of ferroptosis GO:0005886 plasma membrane false UniProtKB:Q13131-2 PRKAA1 Hsap 680ad14200003459 ALDH7A1 protects against ferroptosis by generating membrane NADH, thereby supporting AIFM2 activity (Human). NCBITaxon:9606 gomodel:680ad14200003459/680ad14200003484 GO:0004674 protein serine/threonine kinase activity GO:0072659 protein localization to plasma membrane false UniProtKB:P49419-2 ALDH7A1 Hsap 680ad14200003459 ALDH7A1 protects against ferroptosis by generating membrane NADH, thereby supporting AIFM2 activity (Human). NCBITaxon:9606 gomodel:680ad14200003459/680ad14200003494 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0110076 negative regulation of ferroptosis GO:0005886 plasma membrane false UniProtKB:Q9Y5P4 CERT1 Hsap 680ad14200003909 C20-ceramide transport activity of CERT1 (Human) NCBITaxon:9606 gomodel:680ad14200003909/680ad14200004337 GO:0120013 lipid transfer activity GO:0035621 ER to Golgi ceramide transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q9Y3I1 FBXO7 Hsap 680ad14200004334 FBXO7 mediates proteosomal degradation of UXT causing inhibition of the NF-KappaB signaling pathway. (Human) NCBITaxon:9606 gomodel:680ad14200004334/680ad14200004335 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:Q9UBK9-1 UXT Hsap 680ad14200004334 FBXO7 mediates proteosomal degradation of UXT causing inhibition of the NF-KappaB signaling pathway. (Human) NCBITaxon:9606 gomodel:680ad14200004334/680ad14200004411 GO:0003714 transcription corepressor activity GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 680ad14200004334 FBXO7 mediates proteosomal degradation of UXT causing inhibition of the NF-KappaB signaling pathway. (Human) NCBITaxon:9606 gomodel:680ad14200004334/680ad14200004563 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9Y5P4 CERT1 Hsap 680ad14200004532 C16-ceramide transport activity of CERT1 (Human) NCBITaxon:9606 gomodel:680ad14200004532/680ad14200004534 GO:0120017 ceramide transfer activity GO:0035621 ER to Golgi ceramide transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q9Y5P4 CERT1 Hsap 680ad14200004594 C18-ceramide transport activity of CERT1 (Human) NCBITaxon:9606 gomodel:680ad14200004594/680ad14200004596 GO:0120017 ceramide transfer activity GO:0035621 ER to Golgi ceramide transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q9Y5P4 CERT1 Hsap 680ad14200004624 C14-ceramide transport activity of CERT1 (Human) NCBITaxon:9606 gomodel:680ad14200004624/680ad14200004626 GO:0120017 ceramide transfer activity GO:0035621 ER to Golgi ceramide transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q9UKF7 PITPNC1 Hsap 680ad14200004675 Phosphatidylinositol and phosphatidic acid transport by PITPNC1 (response to PLD) (Human) NCBITaxon:9606 gomodel:680ad14200004675/680ad14200004677 GO:0120014 phospholipid transfer activity GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q96MU7 YTHDC1 Hsap 680ad14200005137 YTHDC1 promotes BAT development by stabilizing PPARG (Human) NCBITaxon:9606 gomodel:680ad14200005137/680ad14200005147 GO:0140313 molecular sequestering activity GO:0050873 brown fat cell differentiation GO:0005634 nucleus false UniProtKB:P37231 PPARG Hsap 680ad14200005137 YTHDC1 promotes BAT development by stabilizing PPARG (Human) NCBITaxon:9606 gomodel:680ad14200005137/680ad14200005184 GO:0003700 DNA-binding transcription factor activity GO:0050873 brown fat cell differentiation GO:0005634 nucleus false UniProtKB:O95376 ARIH2 Hsap 680ad14200005137 YTHDC1 promotes BAT development by stabilizing PPARG (Human) NCBITaxon:9606 gomodel:680ad14200005137/680ad14200005530 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P22059 OSBP Hsap 680ad14200005268 Lipid transport activity of OSBP: 25-hydroxycholesterol (Human) NCBITaxon:9606 gomodel:680ad14200005268/680ad14200005272 GO:0120013 lipid transfer activity GO:0006869 lipid transport GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false GO:7770015 intermembrane lipid transporter complex 680ad14200005355 PS/PtdIns4P exchange by OSBPL9/OSBPL11 in the ER-trans Gogi membrane contact site (Human) NCBITaxon:9606 gomodel:680ad14200005355/680ad14200005356 GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity GO:0006649 phospholipid transfer to membrane GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false GO:7770015 intermembrane lipid transporter complex 680ad14200005392 PS/PtdIns4P exchange by OSBPL9/OSBPL10 in ER-endosome membrane contact site (Human) NCBITaxon:9606 gomodel:680ad14200005392/680ad14200005397 GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity GO:0006649 phospholipid transfer to membrane GO:0140284 endoplasmic reticulum-endosome membrane contact site false UniProtKB:P30825 SLC7A1 Hsap 680ad14200005650 SLC7A1 transporter for L-arginine (Human) NCBITaxon:9606 gomodel:680ad14200005650/680ad14200005669 GO:0061459 L-arginine transmembrane transporter activity GO:1903826 L-arginine transmembrane transport GO:0005886 plasma membrane false UniProtKB:P07550 ADRB2 Hsap 680ad14200005705 Signaling by noradrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005705/680ad14200005706 GO:0004941 beta2-adrenergic receptor activity GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200005705 Signaling by noradrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005705/680ad14200005708 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200005705 Signaling by noradrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005705/680ad14200005710 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P07550 ADRB2 Hsap 680ad14200005738 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-i (inhibitory)_Cardioprotection (Human) NCBITaxon:9606 gomodel:680ad14200005738/680ad14200005739 GO:0004941 beta2-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200005738 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-i (inhibitory)_Cardioprotection (Human) NCBITaxon:9606 gomodel:680ad14200005738/680ad14200005740 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200005738 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-i (inhibitory)_Cardioprotection (Human) NCBITaxon:9606 gomodel:680ad14200005738/680ad14200005741 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P07550 ADRB2 Hsap 680ad14200005774 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005774/680ad14200005775 GO:0004941 beta2-adrenergic receptor activity GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200005774 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005774/680ad14200005777 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200005774 Signaling by adrenaline mediated by ADRB2 receptor via G-alpha-s (activatory)_Cardiomyocyte contraction (Human) NCBITaxon:9606 gomodel:680ad14200005774/680ad14200005779 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q96FN5 KIF12 Hsap 680ad14200005824 KIF12 involved in negative regulation of fatty acid biosynthesis via ACACA ubiquitination by COP1 (Human) NCBITaxon:9606 gomodel:680ad14200005824/680ad14200005825 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8NHY2 COP1 Hsap 680ad14200005824 KIF12 involved in negative regulation of fatty acid biosynthesis via ACACA ubiquitination by COP1 (Human) NCBITaxon:9606 gomodel:680ad14200005824/680ad14200005846 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q13085 ACACA Hsap 680ad14200005824 KIF12 involved in negative regulation of fatty acid biosynthesis via ACACA ubiquitination by COP1 (Human) NCBITaxon:9606 gomodel:680ad14200005824/680ad14200005862 GO:0003989 acetyl-CoA carboxylase activity GO:0006633 fatty acid biosynthetic process false UniProtKB:Q9Y620 RAD54B Hsap 680ad14200006012 Negative regulation of signal transduction by p53 by RAD54B (Human) NCBITaxon:9606 gomodel:680ad14200006012/680ad14200006013 GO:0030674 protein-macromolecule adaptor activity GO:1901797 negative regulation of signal transduction by p53 class mediator GO:0005654 nucleoplasm false UniProtKB:Q00987 MDM2 Hsap 680ad14200006012 Negative regulation of signal transduction by p53 by RAD54B (Human) NCBITaxon:9606 gomodel:680ad14200006012/680ad14200006066 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005654 nucleoplasm false UniProtKB:O15151 MDM4 Hsap 680ad14200006012 Negative regulation of signal transduction by p53 by RAD54B (Human) NCBITaxon:9606 gomodel:680ad14200006012/680ad14200006096 GO:0008047 enzyme activator activity GO:1901797 negative regulation of signal transduction by p53 class mediator GO:0005654 nucleoplasm false UniProtKB:P04637 TP53 Hsap 680ad14200006012 Negative regulation of signal transduction by p53 by RAD54B (Human) NCBITaxon:9606 gomodel:680ad14200006012/680ad14200006105 GO:1990841 promoter-specific chromatin binding GO:0072331 signal transduction by p53 class mediator GO:0005654 nucleoplasm false UniProtKB:Q969P5 FBXO32 Hsap 680ad14200006016 The SCF(FBXO312) complex mediates ubiquitination and stablization of CCND1(Human). NCBITaxon:9606 gomodel:680ad14200006016/680ad14200006034 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0062026 negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 680ad14200006016 The SCF(FBXO312) complex mediates ubiquitination and stablization of CCND1(Human). NCBITaxon:9606 gomodel:680ad14200006016/680ad14200006045 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination false UniProtKB:P24385 CCND1 Hsap 680ad14200006016 The SCF(FBXO312) complex mediates ubiquitination and stablization of CCND1(Human). NCBITaxon:9606 gomodel:680ad14200006016/680ad14200006074 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity GO:0000082 G1/S transition of mitotic cell cycle GO:0005737 cytoplasm false UniProtKB:P22362 CCL1 Hsap 680ad14200006125 CCL1-CCR8 axis (Human) NCBITaxon:9606 gomodel:680ad14200006125/680ad14200006126 GO:0008009 chemokine activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0005576 extracellular region false UniProtKB:P51685 CCR8 Hsap 680ad14200006125 CCL1-CCR8 axis (Human) NCBITaxon:9606 gomodel:680ad14200006125/680ad14200006133 GO:0004930 G protein-coupled receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 680ad14200006125 CCL1-CCR8 axis (Human) NCBITaxon:9606 gomodel:680ad14200006125/680ad14200006143 GO:0003925 G protein activity GO:0007186 G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q06609 RAD51 Hsap 680ad14200006156 RAD51 and RAD54B cooperate in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200006156/680ad14200006159 GO:0000150 DNA strand exchange activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9Y620 RAD54B Hsap 680ad14200006156 RAD51 and RAD54B cooperate in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200006156/680ad14200006162 GO:0008094 ATP-dependent activity, acting on DNA GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9Y620 RAD54B Hsap 680ad14200006156 RAD51 and RAD54B cooperate in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200006156/680ad14200007271 GO:0008094 ATP-dependent activity, acting on DNA GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P30825 SLC7A1 Hsap 680ad14200006511 SLC7A1a transporter for L-lysine (Human) NCBITaxon:9606 gomodel:680ad14200006511/680ad14200006514 GO:0015189 L-lysine transmembrane transporter activity GO:1903401 L-lysine transmembrane transport GO:0005886 plasma membrane false UniProtKB:P30825 SLC7A1 Hsap 680ad14200006549 SLC7A1a transporter for L-ornithine (Human) NCBITaxon:9606 gomodel:680ad14200006549/680ad14200006552 GO:0000064 L-ornithine transmembrane transporter activity GO:1903352 L-ornithine transmembrane transport GO:0005886 plasma membrane false UniProtKB:P30825 SLC7A1 Hsap 680ad14200006567 SLC7A1 transporter for L-homoarginine (Human) NCBITaxon:9606 gomodel:680ad14200006567/680ad14200006570 GO:0008324 monoatomic cation transmembrane transporter activity GO:0098655 monoatomic cation transmembrane transport GO:0005886 plasma membrane false UniProtKB:P13945 ADRB3 Hsap 680ad14200006651 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Inotropic inhibition (Human) NCBITaxon:9606 gomodel:680ad14200006651/680ad14200006652 GO:0015052 beta3-adrenergic receptor activity GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200006651 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Inotropic inhibition (Human) NCBITaxon:9606 gomodel:680ad14200006651/680ad14200006653 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200006651 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Inotropic inhibition (Human) NCBITaxon:9606 gomodel:680ad14200006651/680ad14200006654 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P13945 ADRB3 Hsap 680ad14200006724 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Lipolysis & thermogenesis (Human) NCBITaxon:9606 gomodel:680ad14200006724/680ad14200006725 GO:0015052 beta3-adrenergic receptor activity GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200006724 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Lipolysis & thermogenesis (Human) NCBITaxon:9606 gomodel:680ad14200006724/680ad14200006727 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200006724 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Lipolysis & thermogenesis (Human) NCBITaxon:9606 gomodel:680ad14200006724/680ad14200006729 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P13945 ADRB3 Hsap 680ad14200006794 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Detrusor relaxation (Human) NCBITaxon:9606 gomodel:680ad14200006794/680ad14200006795 GO:0015052 beta3-adrenergic receptor activity GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 680ad14200006794 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Detrusor relaxation (Human) NCBITaxon:9606 gomodel:680ad14200006794/680ad14200006797 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200006794 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-s (activatory)_Detrusor relaxation (Human) NCBITaxon:9606 gomodel:680ad14200006794/680ad14200006799 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P36969 GPX4 Hsap 680ad14200007162 GPX4 is degraded via chaperone-mediated autophagy (Human). NCBITaxon:9606 gomodel:680ad14200007162/680ad14200007170 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity GO:0110076 negative regulation of ferroptosis false UniProtKB:P11142 HSPA8 Hsap 680ad14200007162 GPX4 is degraded via chaperone-mediated autophagy (Human). NCBITaxon:9606 gomodel:680ad14200007162/680ad14200007175 GO:0030674 protein-macromolecule adaptor activity GO:0061684 chaperone-mediated autophagy GO:0005737 cytoplasm false UniProtKB:P13473 LAMP2 Hsap 680ad14200007162 GPX4 is degraded via chaperone-mediated autophagy (Human). NCBITaxon:9606 gomodel:680ad14200007162/680ad14200007186 GO:0030674 protein-macromolecule adaptor activity GO:0061684 chaperone-mediated autophagy GO:0005765 lysosomal membrane false UniProtKB:P36969 GPX4 Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007202 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity GO:0110076 negative regulation of ferroptosis false UniProtKB:P11142 HSPA8 Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007207 GO:0030674 protein-macromolecule adaptor activity GO:0061684 chaperone-mediated autophagy GO:0005737 cytoplasm false UniProtKB:P13473 LAMP2 Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007218 GO:0030674 protein-macromolecule adaptor activity GO:0061684 chaperone-mediated autophagy GO:0005765 lysosomal membrane false UniProtKB:Q9H6Z9 EGLN3 Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007233 GO:0031545 peptidyl-proline 4-dioxygenase activity GO:0050821 protein stabilization false UniProtKB:Q9Y617 PSAT1 Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007243 GO:0004648 O-phospho-L-serine:2-oxoglutarate transaminase activity GO:0110076 negative regulation of ferroptosis false UniProtKB:Q9UQM7 CAMK2A Hsap 680ad14200007201 GPX4 hydroxylation by EGLN3 prevents its degradation via chaperone-mediated autophagy, inhibiting ferroptosis (Human). NCBITaxon:9606 gomodel:680ad14200007201/680ad14200007252 GO:0004674 protein serine/threonine kinase activity GO:0110076 negative regulation of ferroptosis false UniProtKB:P13945 ADRB3 Hsap 680ad14200007287 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Lipolysis (Human) NCBITaxon:9606 gomodel:680ad14200007287/680ad14200007288 GO:0015052 beta3-adrenergic receptor activity GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 680ad14200007287 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Lipolysis (Human) NCBITaxon:9606 gomodel:680ad14200007287/680ad14200007289 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 680ad14200007287 Signaling by noradrenaline mediated by ADRB3 receptor via G-alpha-i (inhibititory)_Lipolysis (Human) NCBITaxon:9606 gomodel:680ad14200007287/680ad14200007290 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q06609 RAD51 Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007323 GO:0000150 DNA strand exchange activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92698 RAD54L Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007331 GO:0008094 ATP-dependent activity, acting on DNA GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q9H8M2 BRD9 Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007345 GO:0030674 protein-macromolecule adaptor activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92698 RAD54L Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007357 GO:0008094 ATP-dependent activity, acting on DNA GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:Q92830 KAT2A Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007370 GO:0061733 protein-lysine-acetyltransferase activity false UniProtKB:Q92831 KAT2B Hsap 680ad14200007322 BRD9 regulates RAD51 and RAD54L in double-strand break repair via homologous recombination (Human) NCBITaxon:9606 gomodel:680ad14200007322/680ad14200007384 GO:0061733 protein-lysine-acetyltransferase activity false UniProtKB:P51677 CCR3 Hsap 680ad14200007665 CCL11-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007665/680ad14200007666 GO:0016493 C-C chemokine receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O95837 GNA14 Hsap 680ad14200007665 CCL11-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007665/680ad14200007673 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q00722 PLCB2 Hsap 680ad14200007665 CCL11-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007665/680ad14200007683 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P51671 CCL11 Hsap 680ad14200007665 CCL11-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007665/680ad14200007738 GO:0008009 chemokine activity GO:0060326 cell chemotaxis GO:0005576 extracellular region false UniProtKB:P51677 CCR3 Hsap 680ad14200007765 CCL24-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007765/680ad14200007766 GO:0016493 C-C chemokine receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O95837 GNA14 Hsap 680ad14200007765 CCL24-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007765/680ad14200007773 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q00722 PLCB2 Hsap 680ad14200007765 CCL24-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007765/680ad14200007783 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O00175 CCL24 Hsap 680ad14200007765 CCL24-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007765/680ad14200007809 GO:0008009 chemokine activity GO:0060326 cell chemotaxis GO:0005576 extracellular region false UniProtKB:P51677 CCR3 Hsap 680ad14200007827 CCL26-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007827/680ad14200007828 GO:0016493 C-C chemokine receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O95837 GNA14 Hsap 680ad14200007827 CCL26-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007827/680ad14200007835 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q00722 PLCB2 Hsap 680ad14200007827 CCL26-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007827/680ad14200007845 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y258 CCL26 Hsap 680ad14200007827 CCL26-CCR3 axis involved in cell chemotaxis (Human) NCBITaxon:9606 gomodel:680ad14200007827/680ad14200007871 GO:0008009 chemokine activity GO:0060326 cell chemotaxis GO:0005576 extracellular region false UniProtKB:P17812 CTPS1 Hsap 682fbcd000000000 Histone H1 deamidation by CTSP1 promotes subsequent acetylation by EP300 and facilitates chromatin relaxation for DNA repair (Human). NCBITaxon:9606 gomodel:682fbcd000000000/682fbcd000000001 GO:0160264 histone H1N76/N77 asparagine deamidase activity GO:1902340 negative regulation of chromosome condensation GO:0000785 chromatin false UniProtKB:Q09472 EP300 Hsap 682fbcd000000000 Histone H1 deamidation by CTSP1 promotes subsequent acetylation by EP300 and facilitates chromatin relaxation for DNA repair (Human). NCBITaxon:9606 gomodel:682fbcd000000000/682fbcd000000012 GO:0160263 histone H1K75 acetyltransferase activity GO:1902340 negative regulation of chromosome condensation GO:0000785 chromatin false UniProtKB:P10412 H1-4 Hsap 682fbcd000000000 Histone H1 deamidation by CTSP1 promotes subsequent acetylation by EP300 and facilitates chromatin relaxation for DNA repair (Human). NCBITaxon:9606 gomodel:682fbcd000000000/682fbcd000000023 GO:0030527 structural constituent of chromatin GO:0030261 chromosome condensation GO:0000792 heterochromatin false UniProtKB:P17812 CTPS1 Hsap 682fbcd000000032 CTPS1 inhibits antiviral interferon induction by deamidating IRF3 (Human). NCBITaxon:9606 gomodel:682fbcd000000032/682fbcd000000033 GO:0160260 protein asparagine deamidase activity GO:0032480 negative regulation of type I interferon production false UniProtKB:P49841 GSK3B Hsap 682fbcd000000032 CTPS1 inhibits antiviral interferon induction by deamidating IRF3 (Human). NCBITaxon:9606 gomodel:682fbcd000000032/682fbcd000000040 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production false UniProtKB:Q14653 IRF3 Hsap 682fbcd000000032 CTPS1 inhibits antiviral interferon induction by deamidating IRF3 (Human). NCBITaxon:9606 gomodel:682fbcd000000032/682fbcd000000048 GO:0003700 DNA-binding transcription factor activity GO:0032481 positive regulation of type I interferon production GO:0005634 nucleus false UniProtKB:Q92793 CREBBP Hsap 682fbcd000002112 SRCAP acts as transcription coactivator in cAMP/PKA signal transduction. (Human) NCBITaxon:9606 gomodel:682fbcd000002112/682fbcd000002113 GO:0003713 transcription coactivator activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false GO:0005952 cAMP-dependent protein kinase complex 682fbcd000002112 SRCAP acts as transcription coactivator in cAMP/PKA signal transduction. (Human) NCBITaxon:9606 gomodel:682fbcd000002112/682fbcd000002120 GO:0004691 cAMP-dependent protein kinase activity GO:0141156 cAMP/PKA signal transduction GO:0005634 nucleus false UniProtKB:Q6ZRS2 SRCAP Hsap 682fbcd000002112 SRCAP acts as transcription coactivator in cAMP/PKA signal transduction. (Human) NCBITaxon:9606 gomodel:682fbcd000002112/682fbcd000002127 GO:0003713 transcription coactivator activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P16220 CREB1 Hsap 682fbcd000002112 SRCAP acts as transcription coactivator in cAMP/PKA signal transduction. (Human) NCBITaxon:9606 gomodel:682fbcd000002112/682fbcd000002136 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000002172 PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). NCBITaxon:9606 gomodel:682fbcd000002172/682fbcd000002173 GO:0140948 histone H3K9 monomethyltransferase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:Q03112-7 MECOM Hsap 682fbcd000002172 PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). NCBITaxon:9606 gomodel:682fbcd000002172/682fbcd000002182 GO:0140948 histone H3K9 monomethyltransferase activity GO:0051604 protein maturation GO:0005737 cytoplasm false UniProtKB:Q8TEX9 IPO4 Hsap 682fbcd000002172 PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). NCBITaxon:9606 gomodel:682fbcd000002172/682fbcd000002191 GO:0061608 nuclear import signal receptor activity GO:0006606 protein import into nucleus GO:0005737 cytoplasm false UniProtKB:Q9Y294 ASF1A Hsap 682fbcd000002172 PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). NCBITaxon:9606 gomodel:682fbcd000002172/682fbcd000002202 GO:0140713 histone chaperone activity GO:0006334 nucleosome assembly GO:0000785 chromatin false UniProtKB:O43463 SUV39H1 Hsap 682fbcd000002172 PRDM16 and MECOM catalyze histone H3 H3K9me monomethylation in the cytoplasm, before histone H3 import in the nucleus, incorporation into nucleosome and trimethylation by SUV39H1 (Human). NCBITaxon:9606 gomodel:682fbcd000002172/682fbcd000002214 GO:0140949 histone H3K9 trimethyltransferase activity GO:0070828 heterochromatin organization GO:0000785 chromatin false UniProtKB:Q92583 CCL17 Hsap 682fbcd000002323 CCL17-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002323/682fbcd000002324 GO:0008009 chemokine activity GO:0060326 cell chemotaxis GO:0005576 extracellular region false UniProtKB:P51679 CCR4 Hsap 682fbcd000002323 CCL17-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002323/682fbcd000002331 GO:0016493 C-C chemokine receptor activity GO:0060326 cell chemotaxis GO:0005886 plasma membrane false UniProtKB:P32121 ARRB2 Hsap 682fbcd000002323 CCL17-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002323/682fbcd000002344 GO:0060090 molecular adaptor activity GO:0060326 cell chemotaxis GO:0005737 cytoplasm false UniProtKB:O00626 CCL22 Hsap 682fbcd000002354 CCL22-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002354/682fbcd000002355 GO:0008009 chemokine activity GO:0060326 cell chemotaxis GO:0005576 extracellular region false UniProtKB:P51679 CCR4 Hsap 682fbcd000002354 CCL22-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002354/682fbcd000002362 GO:0016493 C-C chemokine receptor activity GO:0060326 cell chemotaxis GO:0005886 plasma membrane false UniProtKB:P32121 ARRB2 Hsap 682fbcd000002354 CCL22-CCR4 mediated recruitment of ARRB2 in T-cell chemotaxis (Human) NCBITaxon:9606 gomodel:682fbcd000002354/682fbcd000002375 GO:0060090 molecular adaptor activity GO:0060326 cell chemotaxis GO:0005737 cytoplasm false RNAcentral:URS000003F392_9606 URS000003F392_9606 Hsap 682fbcd000002551 FAISL NCBITaxon:9606 gomodel:682fbcd000002551/682fbcd000002553 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity GO:0045861 negative regulation of proteolysis GO:0005829 cytosol false UniProtKB:P17655 CAPN2 Hsap 682fbcd000002551 FAISL NCBITaxon:9606 gomodel:682fbcd000002551/682fbcd000002559 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity GO:0051895 negative regulation of focal adhesion assembly GO:0005829 cytosol false UniProtKB:Q05397 PTK2 Hsap 682fbcd000002551 FAISL NCBITaxon:9606 gomodel:682fbcd000002551/684b6c8100004264 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0051894 positive regulation of focal adhesion assembly false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003102 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:P37231-2 PPARG Hsap 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003111 GO:0004879 nuclear receptor activity GO:0045444 fat cell differentiation GO:0005634 nucleus false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003123 GO:0140947 histone H3K9me2 methyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003130 GO:0003713 transcription coactivator activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003142 GO:0140949 histone H3K9 trimethyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false GO:0016592 mediator complex 682fbcd000003101 PRDM16 acts as a key chromatin adapter that mediates differentiation of brown adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000003101/682fbcd000003153 GO:0003713 transcription coactivator activity GO:0051123 RNA polymerase II preinitiation complex assembly GO:0000785 chromatin false UniProtKB:Q6DN90 IQSEC1 Hsap 682fbcd000003765 Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003765/6918f23700004420 GO:0005085 guanyl-nucleotide exchange factor activity GO:0051893 regulation of focal adhesion assembly GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:P17252 PRKCA Hsap 682fbcd000003765 Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003765/6918f23700004433 GO:0004674 protein serine/threonine kinase activity GO:0051893 regulation of focal adhesion assembly GO:0005886 plasma membrane false UniProtKB:Q9H4L5 OSBPL3 Hsap 682fbcd000003765 Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003765/69ea894900004394 GO:7770011 lipid exchange activity GO:0051893 regulation of focal adhesion assembly GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q9P0L0 VAPA Hsap 682fbcd000003765 Regulation of focal adhesion assembly: OSBPL3 transports PI4P and PC between PM and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003765/69ea894900004401 GO:0043495 protein-membrane adaptor activity GO:0051893 regulation of focal adhesion assembly GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9BXW6 OSBPL1A Hsap 682fbcd000003781 OSBPL1A sensor for cholesterol transport between late endosome/lysosome and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003781/682fbcd000003784 GO:0032935 sterol sensor activity GO:0090120 lysosome to ER cholesterol transport GO:0140284 endoplasmic reticulum-endosome membrane contact site false GO:0032991 protein-containing complex 682fbcd000003781 OSBPL1A sensor for cholesterol transport between late endosome/lysosome and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003781/6870555700003071 GO:0032935 sterol sensor activity GO:0090120 lysosome to ER cholesterol transport GO:0010008 endosome membrane false UniProtKB:Q9P0L0 VAPA Hsap 682fbcd000003781 OSBPL1A sensor for cholesterol transport between late endosome/lysosome and ER (Human) NCBITaxon:9606 gomodel:682fbcd000003781/689e7a5d00005259 GO:0043495 protein-membrane adaptor activity GO:0042632 cholesterol homeostasis GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000004101 CBX4 promotes PRDM16 stability by preventing its ubiquitination and degradation (Human). NCBITaxon:9606 gomodel:682fbcd000004101/682fbcd000004102 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000004101 CBX4 promotes PRDM16 stability by preventing its ubiquitination and degradation (Human). NCBITaxon:9606 gomodel:682fbcd000004101/682fbcd000004142 GO:0140949 histone H3K9 trimethyltransferase activity GO:0050873 brown fat cell differentiation GO:0000785 chromatin false UniProtKB:O00257 CBX4 Hsap 682fbcd000004101 CBX4 promotes PRDM16 stability by preventing its ubiquitination and degradation (Human). NCBITaxon:9606 gomodel:682fbcd000004101/682fbcd000004161 GO:0061665 SUMO ligase activity GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process false GO:7770015 intermembrane lipid transporter complex 682fbcd000004233 PS 32:0/PtdIns4P exchange by OSBPL5/OSBPL8 in the ER-PM membrane contact site (Human) NCBITaxon:9606 gomodel:682fbcd000004233/682fbcd000004265 GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity GO:0120010 intermembrane phospholipid transfer GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004639 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004660 GO:0140947 histone H3K9me2 methyltransferase activity GO:0050873 brown fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004667 GO:0003713 transcription coactivator activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004679 GO:0140949 histone H3K9 trimethyltransferase activity GO:0050873 brown fat cell differentiation GO:0000785 chromatin false GO:0016592 mediator complex 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004688 GO:0003713 transcription coactivator activity GO:0051123 RNA polymerase II preinitiation complex assembly GO:0000785 chromatin false UniProtKB:O15382 BCAT2 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004698 GO:0004084 branched-chain-amino-acid:2-oxoglutarate transaminase activity GO:0009083 branched-chain amino acid catabolic process GO:0005739 mitochondrion true branched_chain_amino_acid_catabolism UniProtKB:Q09472 EP300 Hsap 682fbcd000004638 BCAT2 provides acetyl-CoA upstream of EP300, leading to acetylation and inhibition of PRDM16 (Human). NCBITaxon:9606 gomodel:682fbcd000004638/682fbcd000004705 GO:0061733 protein-lysine-acetyltransferase activity GO:1903444 negative regulation of brown fat cell differentiation false UniProtKB:O15123 ANGPT2 Hsap 682fbcd000004727 ANGPT2 does not promote angiogenesis via TIE2 signaling in differentiated blood vessel endothelial cells (i.e.humbelical vein endothelial cells HUVEC) (Human) NCBITaxon:9606 gomodel:682fbcd000004727/682fbcd000004730 GO:0048018 receptor ligand activity GO:0048014 Tie signaling pathway false UniProtKB:Q02763 TEK Hsap 682fbcd000004727 ANGPT2 does not promote angiogenesis via TIE2 signaling in differentiated blood vessel endothelial cells (i.e.humbelical vein endothelial cells HUVEC) (Human) NCBITaxon:9606 gomodel:682fbcd000004727/682fbcd000005174 GO:0019199 transmembrane receptor protein kinase activity GO:0048014 Tie signaling pathway GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 682fbcd000004727 ANGPT2 does not promote angiogenesis via TIE2 signaling in differentiated blood vessel endothelial cells (i.e.humbelical vein endothelial cells HUVEC) (Human) NCBITaxon:9606 gomodel:682fbcd000004727/682fbcd000005200 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004751 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:P37231-2 PPARG Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004760 GO:0004879 nuclear receptor activity GO:0045444 fat cell differentiation GO:0005634 nucleus false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004772 GO:0140947 histone H3K9me2 methyltransferase activity GO:0050873 brown fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9HAZ2 PRDM16 Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004779 GO:0003713 transcription coactivator activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004791 GO:0140949 histone H3K9 trimethyltransferase activity GO:0050873 brown fat cell differentiation GO:0000785 chromatin false GO:0016592 mediator complex 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004800 GO:0003713 transcription coactivator activity GO:0051123 RNA polymerase II preinitiation complex assembly GO:0000785 chromatin false UniProtKB:Q04726 TLE3 Hsap 682fbcd000004750 TLE3 acts as a chromatin adapter that mediates differentiation of white adipocytes and prevents browning of adipocytes (Human). NCBITaxon:9606 gomodel:682fbcd000004750/682fbcd000004810 GO:0003713 transcription coactivator activity GO:0050872 white fat cell differentiation GO:0000785 chromatin false UniProtKB:O15123 ANGPT2 Hsap 682fbcd000005208 ANGPT2 promotes angiogenesis via TIE2 signaling in endothelial progenitor cells (Human) NCBITaxon:9606 gomodel:682fbcd000005208/682fbcd000005209 GO:0048018 receptor ligand activity GO:0048014 Tie signaling pathway false UniProtKB:Q02763 TEK Hsap 682fbcd000005208 ANGPT2 promotes angiogenesis via TIE2 signaling in endothelial progenitor cells (Human) NCBITaxon:9606 gomodel:682fbcd000005208/682fbcd000005213 GO:0019199 transmembrane receptor protein kinase activity GO:0048014 Tie signaling pathway GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 682fbcd000005208 ANGPT2 promotes angiogenesis via TIE2 signaling in endothelial progenitor cells (Human) NCBITaxon:9606 gomodel:682fbcd000005208/682fbcd000005220 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:O15123 ANGPT2 Hsap 682fbcd000005285 ANGPT2 promotes angiogenesis via TIE2 signaling in lymphatic endothelial cells (Human) NCBITaxon:9606 gomodel:682fbcd000005285/682fbcd000005286 GO:0048018 receptor ligand activity GO:0048014 Tie signaling pathway false UniProtKB:Q02763 TEK Hsap 682fbcd000005285 ANGPT2 promotes angiogenesis via TIE2 signaling in lymphatic endothelial cells (Human) NCBITaxon:9606 gomodel:682fbcd000005285/682fbcd000005290 GO:0019199 transmembrane receptor protein kinase activity GO:0048014 Tie signaling pathway GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 682fbcd000005285 ANGPT2 promotes angiogenesis via TIE2 signaling in lymphatic endothelial cells (Human) NCBITaxon:9606 gomodel:682fbcd000005285/682fbcd000005297 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q9HAZ2 PRDM16 Hsap 684b6c8100000003 PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). NCBITaxon:9606 gomodel:684b6c8100000003/684b6c8100000004 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:P37231-2 PPARG Hsap 684b6c8100000003 PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). NCBITaxon:9606 gomodel:684b6c8100000003/684b6c8100000013 GO:0004879 nuclear receptor activity GO:0045444 fat cell differentiation GO:0005634 nucleus false UniProtKB:Q9H9B1 EHMT1 Hsap 684b6c8100000003 PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). NCBITaxon:9606 gomodel:684b6c8100000003/684b6c8100000025 GO:0140947 histone H3K9me2 methyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 684b6c8100000003 PRDM16 acts as a key chromatin adapter that mediates differentiation of beige adipocytes from white adipocytes (Human). NCBITaxon:9606 gomodel:684b6c8100000003/684b6c8100000044 GO:0140949 histone H3K9 trimethyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9HAZ2 PRDM16 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000068 GO:0003714 transcription corepressor activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000089 GO:0140947 histone H3K9me2 methyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false UniProtKB:Q9H9B1 EHMT1 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000096 GO:0140949 histone H3K9 trimethyltransferase activity GO:0160275 negative regulation of white fat cell differentiation GO:0000785 chromatin false UniProtKB:Q13617 CUL2 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000109 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q92624 APPBP2 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000116 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 684b6c8100000067 CRL2(APPBP2) complex inhibits beige fat cell differentiation by mediating ubiquitination of PRDM16, leading to its degradation by the proteasome (Human). NCBITaxon:9606 gomodel:684b6c8100000067/684b6c8100000125 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P36508 ZNF76 Hsap 684b6c8100000137 Sumoylation of ZNF76 by PIAS1 inhibits ZNF76 ability to inhibit TATA-binding protein (TBP) (Human). NCBITaxon:9606 gomodel:684b6c8100000137/684b6c8100000138 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0000122 negative regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:P20226 TBP Hsap 684b6c8100000137 Sumoylation of ZNF76 by PIAS1 inhibits ZNF76 ability to inhibit TATA-binding protein (TBP) (Human). NCBITaxon:9606 gomodel:684b6c8100000137/684b6c8100000145 GO:0016251 RNA polymerase II general transcription initiation factor activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II GO:0000785 chromatin false UniProtKB:O75925 PIAS1 Hsap 684b6c8100000137 Sumoylation of ZNF76 by PIAS1 inhibits ZNF76 ability to inhibit TATA-binding protein (TBP) (Human). NCBITaxon:9606 gomodel:684b6c8100000137/684b6c8100000153 GO:0061665 SUMO ligase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:P36508 ZNF76 Hsap 684b6c8100000161 Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). NCBITaxon:9606 gomodel:684b6c8100000161/684b6c8100000162 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0000122 negative regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:P20226 TBP Hsap 684b6c8100000161 Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). NCBITaxon:9606 gomodel:684b6c8100000161/684b6c8100000169 GO:0016251 RNA polymerase II general transcription initiation factor activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II GO:0000785 chromatin false UniProtKB:O75925 PIAS1 Hsap 684b6c8100000161 Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). NCBITaxon:9606 gomodel:684b6c8100000161/684b6c8100000177 GO:0061665 SUMO ligase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:Q09472 EP300 Hsap 684b6c8100000161 Acetylation of ZNF76 by EP300 prevents sumoylation of ZNF76 by PIAS1 (Human). NCBITaxon:9606 gomodel:684b6c8100000161/684b6c8100000185 GO:0061733 protein-lysine-acetyltransferase activity GO:0000122 negative regulation of transcription by RNA polymerase II false UniProtKB:Q96LB2 MRGPRX1 Hsap 684b6c8100001012 Perception of itch via MRGPRX1-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001012/684b6c8100001013 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 684b6c8100001012 Perception of itch via MRGPRX1-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001012/684b6c8100001014 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 684b6c8100001012 Perception of itch via MRGPRX1-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001012/684b6c8100001015 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01210 PENK Hsap 684b6c8100001012 Perception of itch via MRGPRX1-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001012/684b6c8100001044 GO:0048018 receptor ligand activity GO:0160025 sensory perception of itch GO:0005576 extracellular region false UniProtKB:Q96LB2 MRGPRX1 Hsap 684b6c8100001054 Perception of itch via MRGPRX1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001054/684b6c8100001055 GO:0004930 G protein-coupled receptor activity GO:0160025 sensory perception of itch GO:0005886 plasma membrane false UniProtKB:P01210 PENK Hsap 684b6c8100001054 Perception of itch via MRGPRX1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001054/684b6c8100001084 GO:0048018 receptor ligand activity GO:0160025 sensory perception of itch GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 684b6c8100001054 Perception of itch via MRGPRX1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001054/684b6c8100001094 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 684b6c8100001054 Perception of itch via MRGPRX1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by BAM8-22 peptide from PENK (Human). NCBITaxon:9606 gomodel:684b6c8100001054/684b6c8100001101 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q99536 VAT1 Hsap 684b6c8100001124 VAT1 as a lipid intermembrane transfer protein (Human) NCBITaxon:9606 gomodel:684b6c8100001124/684b6c8100001125 GO:0120014 phospholipid transfer activity GO:0120010 intermembrane phospholipid transfer GO:0005829 cytosol false UniProtKB:P19367 HK1 Hsap 684b6c8100001511 Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) NCBITaxon:9606 gomodel:684b6c8100001511/684b6c8100001526 GO:0004340 glucokinase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P06744 GPI Hsap 684b6c8100001511 Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) NCBITaxon:9606 gomodel:684b6c8100001511/684b6c8100001542 GO:0047938 glucose-6-phosphate 1-epimerase activity GO:0051156 glucose 6-phosphate metabolic process GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P06744 GPI Hsap 684b6c8100001511 Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) NCBITaxon:9606 gomodel:684b6c8100001511/684b6c8100001552 GO:0047938 glucose-6-phosphate 1-epimerase activity GO:0051156 glucose 6-phosphate metabolic process GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P06744 GPI Hsap 684b6c8100001511 Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) NCBITaxon:9606 gomodel:684b6c8100001511/684b6c8100001561 GO:0004347 glucose-6-phosphate isomerase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P06744 GPI Hsap 684b6c8100001511 Glucose-6-phosphate isomerase, anomerase and epimerase activites of GPI (Human) NCBITaxon:9606 gomodel:684b6c8100001511/684b6c8100001583 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0051156 glucose 6-phosphate metabolic process GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P19367 HK1 Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/684b6c8100001670 GO:0004340 glucokinase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P06744 GPI Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/684b6c8100001704 GO:0004347 glucose-6-phosphate isomerase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase GO:0005945 6-phosphofructokinase complex 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/684b6c8100001747 GO:0003872 6-phosphofructokinase activity GO:0061621 canonical glycolysis GO:0005829 cytosol false UniProtKB:P04075 ALDOA Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000101 GO:0004332 fructose-bisphosphate aldolase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P60174 TPI1 Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000122 GO:0004807 triose-phosphate isomerase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:P04406 GAPDH Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000133 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_payoff_phase UniProtKB:P00558 PGK1 Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000144 GO:0004618 phosphoglycerate kinase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_payoff_phase UniProtKB:P18669 PGAM1 Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000155 GO:0004619 phosphoglycerate mutase activity GO:0061621 canonical glycolysis GO:0005829 cytosol false UniProtKB:P06733 ENO1 Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000168 GO:0004634 phosphopyruvate hydratase activity GO:0061621 canonical glycolysis GO:0005829 cytosol false UniProtKB:P14618 PKM Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000181 GO:0004743 pyruvate kinase activity GO:0061621 canonical glycolysis GO:0005829 cytosol true glycolysis_payoff_phase UniProtKB:P06744 GPI Hsap 684b6c8100001669 Canonical Glycolysis (Human) NCBITaxon:9606 gomodel:684b6c8100001669/685de18700000455 GO:0047938 glucose-6-phosphate 1-epimerase activity GO:0051156 glucose 6-phosphate metabolic process GO:0005829 cytosol true glycolysis_investment_phase UniProtKB:Q15389-1 ANGPT1 Hsap 684b6c8100002169 ANGPT1 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:684b6c8100002169/684b6c8100002170 GO:0048018 receptor ligand activity GO:0048014 Tie signaling pathway false UniProtKB:Q02763 TEK Hsap 684b6c8100002169 ANGPT1 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:684b6c8100002169/684b6c8100002174 GO:0019199 transmembrane receptor protein kinase activity GO:0048014 Tie signaling pathway GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 684b6c8100002169 ANGPT1 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:684b6c8100002169/684b6c8100002180 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:Q86SM8 MRGPRE Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002545 GO:0038182 G protein-coupled bile acid receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002547 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P49407 ARRB1 Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002578 GO:0030674 protein-macromolecule adaptor activity GO:0007166 cell surface receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P04075 ALDOA Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002587 GO:0004332 fructose-bisphosphate aldolase activity GO:0006096 glycolytic process true glycolysis_investment_phase UniProtKB:P01275-PRO_0000011258 GCG-GLP-1 Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002596 GO:0005179 hormone activity GO:0050796 regulation of insulin secretion GO:0005576 extracellular region false UniProtKB:Q86SM8 MRGPRE Hsap 684b6c8100002544 "MRGPRE-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and arrestin (ARRB1) following activation by L-tryptophocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome (Human)." NCBITaxon:9606 gomodel:684b6c8100002544/684b6c8100002616 GO:0038182 G protein-coupled bile acid receptor activity GO:0007166 cell surface receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8TDU6 GPBAR1 Hsap 684b6c8100002980 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by lithocholate (Human)." NCBITaxon:9606 gomodel:684b6c8100002980/684b6c8100002981 GO:0038182 G protein-coupled bile acid receptor activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 684b6c8100002980 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by lithocholate (Human)." NCBITaxon:9606 gomodel:684b6c8100002980/684b6c8100002983 GO:0003925 G protein activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 684b6c8100002980 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by lithocholate (Human)." NCBITaxon:9606 gomodel:684b6c8100002980/684b6c8100002985 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q8TDU6 GPBAR1 Hsap 684b6c8100003149 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by deoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003149/684b6c8100003150 GO:0038182 G protein-coupled bile acid receptor activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 684b6c8100003149 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by deoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003149/684b6c8100003152 GO:0003925 G protein activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 684b6c8100003149 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by deoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003149/684b6c8100003154 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q8TDU6 GPBAR1 Hsap 684b6c8100003181 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by chenodeoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003181/684b6c8100003182 GO:0038182 G protein-coupled bile acid receptor activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 684b6c8100003181 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by chenodeoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003181/684b6c8100003184 GO:0003925 G protein activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 684b6c8100003181 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by chenodeoxycholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003181/684b6c8100003186 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q8TDU6 GPBAR1 Hsap 684b6c8100003211 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by cholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003211/684b6c8100003212 GO:0038182 G protein-coupled bile acid receptor activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 684b6c8100003211 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by cholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003211/684b6c8100003214 GO:0003925 G protein activity GO:0038184 adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 684b6c8100003211 "GPBAR1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by cholate (Human)." NCBITaxon:9606 gomodel:684b6c8100003211/684b6c8100003216 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P41002 CCNF Hsap 684b6c8100003601 SCF(Cyclin F) controls centrosome homeostasis through CP110 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003601/684b6c8100003602 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P63208 SKP1 Hsap 684b6c8100003601 SCF(Cyclin F) controls centrosome homeostasis through CP110 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003601/684b6c8100003609 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 684b6c8100003601 SCF(Cyclin F) controls centrosome homeostasis through CP110 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003601/684b6c8100003616 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005634 nucleus false UniProtKB:Q9UQ84 EXO1 Hsap 684b6c8100003601 SCF(Cyclin F) controls centrosome homeostasis through CP110 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003601/684b6c8100003697 GO:0035312 5'-3' DNA exonuclease activity GO:0110025 DNA strand resection involved in replication fork processing GO:0005634 nucleus false UniProtKB:P41002 CCNF Hsap 684b6c8100003650 SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003650/684b6c8100003651 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005813 centrosome false UniProtKB:P63208 SKP1 Hsap 684b6c8100003650 SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003650/684b6c8100003658 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005813 centrosome false UniProtKB:P62877 RBX1 Hsap 684b6c8100003650 SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003650/684b6c8100003665 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005813 centrosome false UniProtKB:O43303 CCP110 Hsap 684b6c8100003650 SCF(Cyclin F) controls cell cycle-dependent execution of double-strand break repair through EXO1degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003650/684b6c8100003673 GO:0008017 microtubule binding GO:0051298 centrosome duplication GO:0005813 centrosome false UniProtKB:P41002 CCNF Hsap 684b6c8100003714 SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003714/684b6c8100003715 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005813 centrosome false UniProtKB:P63208 SKP1 Hsap 684b6c8100003714 SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003714/684b6c8100003722 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005813 centrosome false UniProtKB:P62877 RBX1 Hsap 684b6c8100003714 SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003714/684b6c8100003729 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005813 centrosome false UniProtKB:P31350 RRM2 Hsap 684b6c8100003714 SCF(Cyclin F) controls controls genome integrity and DNA repair through RRM2 degradation (Human) NCBITaxon:9606 gomodel:684b6c8100003714/684b6c8100003762 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0006281 DNA repair GO:0005634 nucleus false UniProtKB:Q96LA9 MRGPRX4 Hsap 684b6c8100003781 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by deoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003781/684b6c8100003782 GO:0038182 G protein-coupled bile acid receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 684b6c8100003781 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by deoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003781/684b6c8100003803 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 684b6c8100003781 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by deoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003781/684b6c8100003810 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q96LA9 MRGPRX4 Hsap 684b6c8100003827 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by chenodeoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003827/684b6c8100003828 GO:0038182 G protein-coupled bile acid receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 684b6c8100003827 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by chenodeoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003827/684b6c8100003841 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 684b6c8100003827 Perception of itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by chenodeoxycholate (Human). NCBITaxon:9606 gomodel:684b6c8100003827/684b6c8100003848 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q96LA9 MRGPRX4 Hsap 684b6c8100003865 Cholestatic itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by 3-sulfated bile acids(Human). NCBITaxon:9606 gomodel:684b6c8100003865/684b6c8100003866 GO:0038182 G protein-coupled bile acid receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 684b6c8100003865 Cholestatic itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by 3-sulfated bile acids(Human). NCBITaxon:9606 gomodel:684b6c8100003865/684b6c8100003879 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 684b6c8100003865 Cholestatic itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by 3-sulfated bile acids(Human). NCBITaxon:9606 gomodel:684b6c8100003865/684b6c8100003886 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q06520 SULT2A1 Hsap 684b6c8100003865 Cholestatic itch via MRGPRX4-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by 3-sulfated bile acids(Human). NCBITaxon:9606 gomodel:684b6c8100003865/684b6c8100003903 GO:0047704 bile-salt sulfotransferase activity GO:0008206 bile acid metabolic process GO:0005829 cytosol false UniProtKB:Q9BXM7 PINK1 Hsap 684b6c8100003917 PINK1-PRKN induction of mitophagy through VDAC1 Lys-27 ubiquitination (Human) NCBITaxon:9606 gomodel:684b6c8100003917/684b6c8100003918 GO:0004674 protein serine/threonine kinase activity GO:0000423 mitophagy GO:0005741 mitochondrial outer membrane false UniProtKB:O60260 PRKN Hsap 684b6c8100003917 PINK1-PRKN induction of mitophagy through VDAC1 Lys-27 ubiquitination (Human) NCBITaxon:9606 gomodel:684b6c8100003917/684b6c8100003927 GO:0061630 ubiquitin protein ligase activity GO:0044314 protein K27-linked ubiquitination GO:0005741 mitochondrial outer membrane false UniProtKB:P21796 VDAC1 Hsap 684b6c8100003917 PINK1-PRKN induction of mitophagy through VDAC1 Lys-27 ubiquitination (Human) NCBITaxon:9606 gomodel:684b6c8100003917/684b6c8100003935 GO:0008308 voltage-gated monoatomic anion channel activity GO:1901526 positive regulation of mitophagy GO:0005741 mitochondrial outer membrane false UniProtKB:P05161 ISG15 Hsap 684b6c8100003917 PINK1-PRKN induction of mitophagy through VDAC1 Lys-27 ubiquitination (Human) NCBITaxon:9606 gomodel:684b6c8100003917/684b6c8100003947 GO:0031386 protein tag activity GO:0032020 ISG15-protein conjugation GO:0005737 cytoplasm false UniProtKB:Q9BZF3 OSBPL6 Hsap 684b6c8100004263 PI4P transfer from PM to ER by OSBPL6 NCBITaxon:9606 gomodel:684b6c8100004263/684b6c8100004281 GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity GO:0120010 intermembrane phospholipid transfer GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q8IXU6 SLC35F2 Hsap 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/684b6c8100004328 GO:0022857 transmembrane transporter activity GO:0160255 tRNA queuosine(34) biosynthetic process from salvaged queuine GO:0005886 plasma membrane false UniProtKB:Q5T6V5 QNG1 Hsap 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/685de18700000087 GO:0106432 queuosine nucleosidase activity GO:0160254 tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors GO:0005829 cytosol false UniProtKB:Q8IXU6 SLC35F2 Hsap 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/685de18700001002 GO:0022857 transmembrane transporter activity GO:0160254 tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors GO:0005886 plasma membrane false CHEBI:33695 information biomacromolecule 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/6882d2b800002866 GO:0016301 kinase activity GO:0160254 tRNA queuosine(34) biosynthetic process from salvaged queuosine or its precursors GO:0005829 cytosol false UniProtKB:Q9BXR0 QTRT1 Hsap 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/6882d2b800003351 GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:Q9H974 QTRT2 Hsap 684b6c8100004302 Bacterial queuine and queuosine salvage for tRNA modification (Human) NCBITaxon:9606 gomodel:684b6c8100004302/6882d2b800003358 GO:0140767 enzyme-substrate adaptor activity GO:0002099 tRNA wobble guanine modification GO:0005737 cytoplasm false UniProtKB:Q96LB1 MRGPRX2 Hsap 685de18700000031 MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by opioids (Human). NCBITaxon:9606 gomodel:685de18700000031/685de18700000032 GO:0004985 G protein-coupled opioid receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 685de18700000031 MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by opioids (Human). NCBITaxon:9606 gomodel:685de18700000031/685de18700000045 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700000031 MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by opioids (Human). NCBITaxon:9606 gomodel:685de18700000031/685de18700000052 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y264-1 ANGPT4 Hsap 685de18700000473 ANGPT4 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:685de18700000473/685de18700000474 GO:0048018 receptor ligand activity GO:0048014 Tie signaling pathway false UniProtKB:Q02763 TEK Hsap 685de18700000473 ANGPT4 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:685de18700000473/685de18700000478 GO:0019199 transmembrane receptor protein kinase activity GO:0048014 Tie signaling pathway false UniProtKB:P31749 AKT1 Hsap 685de18700000473 ANGPT4 promotes angiogenesis via TIE2 signaling in endothelial cells (Human) NCBITaxon:9606 gomodel:685de18700000473/685de18700000484 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:P03126 E6 HPV16 685de18700001168 HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) NCBITaxon:9606 gomodel:685de18700001168/685de18700001176 GO:0140537 transcription regulator activator activity GO:0045944 positive regulation of transcription by RNA polymerase II GO:0042025 host cell nucleus false UniProtKB:Q5T0T0 MARCHF8 Hsap 685de18700001168 HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) NCBITaxon:9606 gomodel:685de18700001168/685de18700001187 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0020002 host cell plasma membrane false UniProtKB:O00220 TNFRSF10A Hsap 685de18700001168 HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) NCBITaxon:9606 gomodel:685de18700001168/685de18700001195 GO:0038023 signaling receptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005886 plasma membrane false UniProtKB:O14763 TNFRSF10B Hsap 685de18700001168 HPV E6 modulates MARCHF8 activity to down-regulate TRAIL-R1 and TRAIL-R2 (Human--HPV) NCBITaxon:9606 gomodel:685de18700001168/685de18700001202 GO:0036463 TRAIL receptor activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8TDS7 MRGPRD Hsap 685de18700001608 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001608/685de18700001609 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 685de18700001608 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001608/685de18700001610 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 685de18700001608 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001608/685de18700001611 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q8TDS7 MRGPRD Hsap 685de18700001650 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001650/685de18700001651 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 685de18700001650 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001650/685de18700001664 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700001650 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-alanine (Human). NCBITaxon:9606 gomodel:685de18700001650/685de18700001671 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O95399 UTS2 Hsap 685de18700001720 Urotensin‐II/US2R leading to ERK1/ERK2 signaling (Human) NCBITaxon:9606 gomodel:685de18700001720/685de18700001721 GO:0005179 hormone activity GO:0008217 regulation of blood pressure GO:0005576 extracellular region false UniProtKB:Q9UKP6 UTS2R Hsap 685de18700001720 Urotensin‐II/US2R leading to ERK1/ERK2 signaling (Human) NCBITaxon:9606 gomodel:685de18700001720/685de18700001728 GO:0004930 G protein-coupled receptor activity GO:0008217 regulation of blood pressure GO:0005886 plasma membrane false UniProtKB:P27361 MAPK3 Hsap 685de18700001720 Urotensin‐II/US2R leading to ERK1/ERK2 signaling (Human) NCBITaxon:9606 gomodel:685de18700001720/685de18700001754 GO:0004707 MAP kinase activity GO:0000165 MAPK cascade GO:0005737 cytoplasm false UniProtKB:P28482 MAPK1 Hsap 685de18700001720 Urotensin‐II/US2R leading to ERK1/ERK2 signaling (Human) NCBITaxon:9606 gomodel:685de18700001720/685de18700001761 GO:0004674 protein serine/threonine kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:P49675 STAR Hsap 685de18700001735 Cholesterol transport between MOM & MIM by STAR (Human) NCBITaxon:9606 gomodel:685de18700001735/685de18700001737 GO:0120020 cholesterol transfer activity GO:0032367 intracellular cholesterol transport GO:0005741 mitochondrial outer membrane true adrenal_steroidogenesis UniProtKB:P49675 STAR Hsap 685de18700001799 Cholesterol transport between MOM & MIM by STAR gonads (Human) NCBITaxon:9606 gomodel:685de18700001799/685de18700001800 GO:0120020 cholesterol transfer activity GO:0032367 intracellular cholesterol transport GO:0005741 mitochondrial outer membrane true adrenal_steroidogenesis UniProtKB:Q8TDS7 MRGPRD Hsap 685de18700002029 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by allantoin (Human). NCBITaxon:9606 gomodel:685de18700002029/685de18700002030 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 685de18700002029 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by allantoin (Human). NCBITaxon:9606 gomodel:685de18700002029/685de18700002039 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700002029 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by allantoin (Human). NCBITaxon:9606 gomodel:685de18700002029/685de18700002046 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:Q8TDS7 MRGPRD Hsap 685de18700002069 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002069/685de18700002070 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 685de18700002069 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002069/685de18700002071 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 685de18700002069 MRGPRD-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002069/685de18700002072 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q8TDS7 MRGPRD Hsap 685de18700002103 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002103/685de18700002104 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 685de18700002103 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002103/685de18700002113 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700002103 MRGPRD-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by beta-aminoisobutyrate (Human). NCBITaxon:9606 gomodel:685de18700002103/685de18700002120 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P35348 ADRA1A Hsap 685de18700002943 Signaling by noradrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700002943/685de18700002944 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700002943 Signaling by noradrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700002943/685de18700002945 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700002943 Signaling by noradrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700002943/685de18700002946 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700002962 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700002981 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003023 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003036 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003045 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003054 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003063 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003105 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003117 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700002961 T cell receptor signaling (Human). NCBITaxon:9606 gomodel:685de18700002961/685de18700003128 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003316 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003335 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003345 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003358 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003367 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003376 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003385 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003398 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003408 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003419 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003429 GO:0004888 transmembrane signaling receptor activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P33681 CD80 Hsap 685de18700003315 Stimulation ot T cell receptor signaling by CD28 following binding to CD80 (Human). NCBITaxon:9606 gomodel:685de18700003315/685de18700003440 GO:0048018 receptor ligand activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003493 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003512 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003522 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003535 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003544 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003553 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003562 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003575 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003585 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003596 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003606 GO:0004888 transmembrane signaling receptor activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P42081 CD86 Hsap 685de18700003492 Stimulation ot T cell receptor signaling by CD28 following binding to CD86 (Human). NCBITaxon:9606 gomodel:685de18700003492/685de18700003627 GO:0048018 receptor ligand activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P16473 TSHR Hsap 685de18700003677 "TSHR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by TSH (Human)." NCBITaxon:9606 gomodel:685de18700003677/685de18700003720 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 685de18700003677 "TSHR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by TSH (Human)." NCBITaxon:9606 gomodel:685de18700003677/685de18700003727 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P20396 TRH Hsap 685de18700003677 "TSHR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by TSH (Human)." NCBITaxon:9606 gomodel:685de18700003677/685de18700005050 GO:0008437 thyrotropin-releasing hormone activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false GO:0042105 alpha-beta T cell receptor complex 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700003891 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700003910 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700003920 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700004004 GO:0004888 transmembrane signaling receptor activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P16410 CTLA4 Hsap 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700004230 GO:0140319 receptor decoy activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P33681 CD80 Hsap 685de18700003890 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD80 (Human). NCBITaxon:9606 gomodel:685de18700003890/685de18700006301 GO:0048018 receptor ligand activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700004046 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700004065 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700004075 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P10747 CD28 Hsap 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700004159 GO:0004888 transmembrane signaling receptor activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P16410 CTLA4 Hsap 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700004211 GO:0140319 receptor decoy activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P42081 CD86 Hsap 685de18700004045 CTLA4 inhibits T-cell activation by acting as a decoy receptor for CD86 (Human). NCBITaxon:9606 gomodel:685de18700004045/685de18700006261 GO:0048018 receptor ligand activity GO:0050862 positive regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0017059 serine palmitoyltransferase complex 685de18700004252 CERS2 galactosylceramide synthesis (Human) NCBITaxon:9606 gomodel:685de18700004252/685de18700004253 GO:0004758 serine C-palmitoyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:Q06136 KDSR Hsap 685de18700004252 CERS2 galactosylceramide synthesis (Human) NCBITaxon:9606 gomodel:685de18700004252/685de18700004276 GO:0047560 3-dehydrosphinganine reductase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q96G23 CERS2 Hsap 685de18700004252 CERS2 galactosylceramide synthesis (Human) NCBITaxon:9606 gomodel:685de18700004252/685de18700004284 GO:0050291 sphingosine N-acyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:O15121 DEGS1 Hsap 685de18700004252 CERS2 galactosylceramide synthesis (Human) NCBITaxon:9606 gomodel:685de18700004252/685de18700004296 GO:0042284 sphingolipid delta-4 desaturase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q16880 UGT8 Hsap 685de18700004252 CERS2 galactosylceramide synthesis (Human) NCBITaxon:9606 gomodel:685de18700004252/685de18700004462 GO:0003851 N-acylsphingosine galactosyltransferase activity GO:0006682 galactosylceramide biosynthetic process GO:0098553 lumenal side of endoplasmic reticulum membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004472 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004491 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004501 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004532 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004554 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004575 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15116 PDCD1 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004603 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9NZQ7 CD274 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004612 GO:0048018 receptor ligand activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06241 FYN Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004625 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050860 negative regulation of T cell receptor signaling pathway false UniProtKB:Q06124 PTPN11 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004635 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0050860 negative regulation of T cell receptor signaling pathway false UniProtKB:Q06124 PTPN11 Hsap 685de18700004471 Activation of PDCD1/PD-1 by CD274 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004471/685de18700004644 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0050860 negative regulation of T cell receptor signaling pathway false GO:0042105 alpha-beta T cell receptor complex 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004683 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004702 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004712 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004725 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20963 CD247 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004735 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004745 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15116 PDCD1 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004764 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06241 FYN Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004785 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050860 negative regulation of T cell receptor signaling pathway false UniProtKB:Q06124 PTPN11 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004794 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0050860 negative regulation of T cell receptor signaling pathway false UniProtKB:Q06124 PTPN11 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004803 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0050860 negative regulation of T cell receptor signaling pathway false UniProtKB:Q9BQ51 PDCD1LG2 Hsap 685de18700004682 Activation of PDCD1/PD-1 by PDCD1LG2 inhibits T-cell activation by promoting recruitment of PTPN11, leading to dephosphorylation of key TCR signaling molecules (Human). NCBITaxon:9606 gomodel:685de18700004682/685de18700004820 GO:0048018 receptor ligand activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P35348 ADRA1A Hsap 685de18700005131 Signaling by adrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005131/685de18700005132 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700005131 Signaling by adrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005131/685de18700005133 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700005131 Signaling by adrenaline mediated by ADRA1A receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005131/685de18700005134 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005172 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005191 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005201 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005214 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005264 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005275 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005303 GO:0048018 receptor ligand activity GO:0050868 negative regulation of T cell activation GO:0005886 plasma membrane false UniProtKB:P22681 CBL Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005312 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005886 plasma membrane false UniProtKB:P18627 LAG3 Hsap 685de18700005171 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005171/685de18700005367 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8IWZ4 TRIM48 Hsap 685de18700005328 TRIM48 promotes ASK1 activation and cell death through ubiquitination of PRMT1 (Human) NCBITaxon:9606 gomodel:685de18700005328/685de18700005329 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q99873 PRMT1 Hsap 685de18700005328 TRIM48 promotes ASK1 activation and cell death through ubiquitination of PRMT1 (Human) NCBITaxon:9606 gomodel:685de18700005328/685de18700005383 GO:0008170 N-methyltransferase activity GO:0043066 negative regulation of apoptotic process GO:0005737 cytoplasm false UniProtKB:Q99683 MAP3K5 Hsap 685de18700005328 TRIM48 promotes ASK1 activation and cell death through ubiquitination of PRMT1 (Human) NCBITaxon:9606 gomodel:685de18700005328/685de18700005394 GO:0004709 MAP kinase kinase kinase activity GO:0097190 apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:P25100 ADRA1D Hsap 685de18700005336 Signaling by noradrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005336/685de18700005337 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700005336 Signaling by noradrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005336/685de18700005338 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700005336 Signaling by noradrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005336/685de18700005339 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005415 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005434 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005444 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005457 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005467 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005478 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005497 GO:0048018 receptor ligand activity GO:0050868 negative regulation of T cell activation GO:0005886 plasma membrane false UniProtKB:Q13191 CBLB Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005505 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005886 plasma membrane false UniProtKB:P18627 LAG3 Hsap 685de18700005414 Inhibition of T cell receptor signaling by LAG3 following binding to MHC class II and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005414/685de18700005520 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005546 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005565 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005575 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005588 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005598 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005609 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P22681 CBL Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005636 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005886 plasma membrane false UniProtKB:P18627 LAG3 Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005651 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q08830 FGL1 Hsap 685de18700005545 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBL (Human). NCBITaxon:9606 gomodel:685de18700005545/685de18700005676 GO:0048018 receptor ligand activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042105 alpha-beta T cell receptor complex 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005691 GO:0032395 MHC class II receptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false GO:0042613 MHC class II protein complex 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005710 GO:0042605 peptide antigen binding GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0005886 plasma membrane false UniProtKB:P01730 CD4 Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005720 GO:0015026 coreceptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06239 LCK Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005733 GO:0004713 protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07766 CD3E Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005743 GO:0030674 protein-macromolecule adaptor activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P43403 ZAP70 Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005754 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0050852 T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q13191 CBLB Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005773 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005886 plasma membrane false UniProtKB:P18627 LAG3 Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005788 GO:0004888 transmembrane signaling receptor activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q08830 FGL1 Hsap 685de18700005690 Inhibition of T cell receptor signaling by LAG3 following binding to FGL1 and ubiquitination by CBLB (Human). NCBITaxon:9606 gomodel:685de18700005690/685de18700005808 GO:0048018 receptor ligand activity GO:0050860 negative regulation of T cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P35368 ADRA1B Hsap 685de18700005822 Signaling by adrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005822/685de18700005823 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700005822 Signaling by adrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005822/685de18700005824 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700005822 Signaling by adrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005822/685de18700005825 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P35368 ADRA1B Hsap 685de18700005866 Signaling by noradrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005866/685de18700005867 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700005866 Signaling by noradrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005866/685de18700005868 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700005866 Signaling by noradrenaline mediated by ADRA1B receptor via G-alpha-q (phospholipase c-activating, IP3, DAG)_Cardiac hypertrophy (Human) NCBITaxon:9606 gomodel:685de18700005866/685de18700005869 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O14626 GPR171 Hsap 685de18700005909 GPR171 a receptor for Big LEN, a neuropeptide regulating feeding behavior. (Human) NCBITaxon:9606 gomodel:685de18700005909/685de18700005936 GO:0008528 G protein-coupled peptide receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UHG2-PRO_0000259679 PCSK1N-b-LEN Hsap 685de18700005909 GPR171 a receptor for Big LEN, a neuropeptide regulating feeding behavior. (Human) NCBITaxon:9606 gomodel:685de18700005909/685de18700005938 GO:0160041 neuropeptide activity GO:0060259 regulation of feeding behavior GO:0005576 extracellular region false UniProtKB:P63096 GNAI1 Hsap 685de18700005909 GPR171 a receptor for Big LEN, a neuropeptide regulating feeding behavior. (Human) NCBITaxon:9606 gomodel:685de18700005909/689e7a5d00003911 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P25100 ADRA1D Hsap 685de18700005944 Signaling by adrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005944/685de18700005945 GO:0004937 alpha1-adrenergic receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 685de18700005944 Signaling by adrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005944/685de18700005946 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 685de18700005944 Signaling by adrenaline mediated by ADRA1D receptor via G-alpha-q (phospholipase c-activating, IP3, DAG) (Human) NCBITaxon:9606 gomodel:685de18700005944/685de18700005947 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9H672 ASB7 Hsap 685de18700006327 ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). NCBITaxon:9606 gomodel:685de18700006327/685de18700006347 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0000792 heterochromatin false UniProtKB:Q93034 CUL5 Hsap 685de18700006327 ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). NCBITaxon:9606 gomodel:685de18700006327/685de18700006359 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9UBF6 RNF7 Hsap 685de18700006327 ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). NCBITaxon:9606 gomodel:685de18700006327/685de18700006367 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:O43463 SUV39H1 Hsap 685de18700006327 ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). NCBITaxon:9606 gomodel:685de18700006327/685de18700006385 GO:0140949 histone H3K9 trimethyltransferase activity GO:0070828 heterochromatin organization GO:0000792 heterochromatin false UniProtKB:P45973 CBX5 Hsap 685de18700006327 ASB7 is a negative regulator of H3K9me3 homeostasis by mediating ubiquitination and degradation of SUV39H1 (Human). NCBITaxon:9606 gomodel:685de18700006327/685de18700006402 GO:0062072 histone H3K9me2/3 reader activity GO:0097355 protein localization to heterochromatin GO:0000792 heterochromatin false UniProtKB:Q9H672 ASB7 Hsap 685de18700006415 CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). NCBITaxon:9606 gomodel:685de18700006415/685de18700006416 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0000792 heterochromatin false UniProtKB:Q93034 CUL5 Hsap 685de18700006415 CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). NCBITaxon:9606 gomodel:685de18700006415/685de18700006427 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9UBF6 RNF7 Hsap 685de18700006415 CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). NCBITaxon:9606 gomodel:685de18700006415/685de18700006434 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:O43463 SUV39H1 Hsap 685de18700006415 CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). NCBITaxon:9606 gomodel:685de18700006415/685de18700006445 GO:0140949 histone H3K9 trimethyltransferase activity GO:0070828 heterochromatin organization GO:0000792 heterochromatin false UniProtKB:P06493 CDK1 Hsap 685de18700006415 CDK1 inhibits ASB7 ability to ubiquitinate SUV39H1 by mediating phosphorylation of ASB7 during mitosis (Human). NCBITaxon:9606 gomodel:685de18700006415/685de18700006477 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0031397 negative regulation of protein ubiquitination false UniProtKB:Q9Y692 GMEB1 Hsap 685de18700006529 GMEB1 interacts with the deubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis (Human) NCBITaxon:9606 gomodel:685de18700006529/685de18700006530 GO:0030674 protein-macromolecule adaptor activity GO:0043066 negative regulation of apoptotic process GO:0005737 cytoplasm false UniProtKB:Q14790 CASP8 Hsap 685de18700006529 GMEB1 interacts with the deubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis (Human) NCBITaxon:9606 gomodel:685de18700006529/685de18700006535 GO:0004197 cysteine-type endopeptidase activity GO:0036462 TRAIL-activated apoptotic signaling pathway GO:0005737 cytoplasm false UniProtKB:O15519 CFLAR Hsap 685de18700006529 GMEB1 interacts with the deubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis (Human) NCBITaxon:9606 gomodel:685de18700006529/685de18700006542 GO:0004197 cysteine-type endopeptidase activity GO:0043066 negative regulation of apoptotic process GO:0005737 cytoplasm false UniProtKB:Q9NVE5 USP40 Hsap 685de18700006529 GMEB1 interacts with the deubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis (Human) NCBITaxon:9606 gomodel:685de18700006529/685de18700006550 GO:0004843 cysteine-type deubiquitinase activity GO:0043066 negative regulation of apoptotic process GO:0005737 cytoplasm false UniProtKB:O43463 SUV39H1 Hsap 685de18700006700 SUV39H1 phosphorylation by CDK2 inhibits its localization to heterochromatin (Human). NCBITaxon:9606 gomodel:685de18700006700/685de18700006730 GO:0140949 histone H3K9 trimethyltransferase activity GO:0070828 heterochromatin organization GO:0000792 heterochromatin false UniProtKB:P24941 CDK2 Hsap 685de18700006700 SUV39H1 phosphorylation by CDK2 inhibits its localization to heterochromatin (Human). NCBITaxon:9606 gomodel:685de18700006700/685de18700006738 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:P45973 CBX5 Hsap 685de18700006700 SUV39H1 phosphorylation by CDK2 inhibits its localization to heterochromatin (Human). NCBITaxon:9606 gomodel:685de18700006700/685de18700006753 GO:0062072 histone H3K9me2/3 reader activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:O14966 RAB29 Hsap 685de18700007432 Regulation of LRRK2 activity by TRIM1 (Human) NCBITaxon:9606 gomodel:685de18700007432/685de18700007433 GO:0019209 kinase activator activity GO:1905503 regulation of motile cilium assembly GO:0005737 cytoplasm false UniProtKB:Q5S007 LRRK2 Hsap 685de18700007432 Regulation of LRRK2 activity by TRIM1 (Human) NCBITaxon:9606 gomodel:685de18700007432/685de18700007440 GO:0004674 protein serine/threonine kinase activity GO:1905504 negative regulation of motile cilium assembly GO:0005737 cytoplasm false UniProtKB:P61026 RAB10 Hsap 685de18700007432 Regulation of LRRK2 activity by TRIM1 (Human) NCBITaxon:9606 gomodel:685de18700007432/685de18700007449 GO:0003925 G protein activity GO:1905504 negative regulation of motile cilium assembly GO:0010008 endosome membrane false UniProtKB:Q9UJV3 MID2 Hsap 685de18700007432 Regulation of LRRK2 activity by TRIM1 (Human) NCBITaxon:9606 gomodel:685de18700007432/685de18700007460 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005874 microtubule false GO:7770015 intermembrane lipid transporter complex 6870555700000578 PS/PtdIns4P exchange by OSBPL9/OSBPL10 in ER-TGN membrane contact site (Human) NCBITaxon:9606 gomodel:6870555700000578/6870555700000583 GO:0160270 phosphatidylserine-phosphatidylinositol-4-phosphate exchange activity GO:0006649 phospholipid transfer to membrane GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:O95461 LARGE1 Hsap 6870555700001150 Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) NCBITaxon:9606 gomodel:6870555700001150/6882d2b800001351 GO:0015020 glucuronosyltransferase activity GO:0035269 protein O-linked glycosylation via mannose GO:0005794 Golgi apparatus false UniProtKB:Q9Y215 COLQ Hsap 6870555700001150 Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) NCBITaxon:9606 gomodel:6870555700001150/689e7a5d00000940 GO:0060090 molecular adaptor activity GO:0035418 protein localization to synapse GO:0031594 neuromuscular junction false UniProtKB:P22303 ACHE Hsap 6870555700001150 Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) NCBITaxon:9606 gomodel:6870555700001150/689e7a5d00000955 GO:0003990 acetylcholinesterase activity GO:0001507 acetylcholine catabolic process in synaptic cleft GO:0031594 neuromuscular junction false UniProtKB:P98160 HSPG2 Hsap 6870555700001150 Perlecan interaction with post-translationally modified dystroglycan is required for acetylcholinesterase localization and accumulation at the neuromuscular junction(Human) NCBITaxon:9606 gomodel:6870555700001150/689e7a5d00001156 GO:0060090 molecular adaptor activity GO:0035418 protein localization to synapse GO:0031594 neuromuscular junction false UniProtKB:P31749 AKT1 Hsap 6870555700001190 Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) NCBITaxon:9606 gomodel:6870555700001190/6870555700001246 GO:0004674 protein serine/threonine kinase activity GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction false UniProtKB:P25391 LAMA1 Hsap 6870555700001190 Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) NCBITaxon:9606 gomodel:6870555700001190/6870555700002179 GO:0048018 receptor ligand activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0031012 extracellular matrix false UniProtKB:Q14118-PRO_0000021065 DAG1-Alpha-DG Hsap 6870555700001190 Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) NCBITaxon:9606 gomodel:6870555700001190/6870555700002192 GO:0005055 laminin receptor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0031012 extracellular matrix false UniProtKB:O95461 LARGE1 Hsap 6870555700001190 Alpha-dystroglycan is a laminin receptor involved in PI3K/AKT signaling activation in muscle (Human) NCBITaxon:9606 gomodel:6870555700001190/6882d2b800000972 GO:0015020 glucuronosyltransferase activity GO:0035269 protein O-linked glycosylation via mannose GO:0005794 Golgi apparatus false UniProtKB:P25391 LAMA1 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001572 GO:0048018 receptor ligand activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:Q14118-PRO_0000021065 DAG1-Alpha-DG Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001577 GO:0005055 laminin receptor activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:P12931 SRC Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001605 GO:0004713 protein tyrosine kinase activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:P62993 GRB2 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001671 GO:0005091 guanyl-nucleotide exchange factor adaptor activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:Q07889 SOS1 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001696 GO:0005085 guanyl-nucleotide exchange factor activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:P63000 RAC1 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700001728 GO:0003924 GTPase activity GO:0016601 Rac protein signal transduction false UniProtKB:Q13424 SNTA1 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6870555700002794 GO:0060090 molecular adaptor activity GO:0035022 positive regulation of Rac protein signal transduction false UniProtKB:O95461 LARGE1 Hsap 6870555700001571 Laminin binding to alpha-dystroglycan activates Rac1 signaling via Src-Grb2-Sos1 (Human) NCBITaxon:9606 gomodel:6870555700001571/6882d2b800000930 GO:0015020 glucuronosyltransferase activity GO:0035269 protein O-linked glycosylation via mannose GO:0005794 Golgi apparatus false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 6870555700002144 Signaling by ACTH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002144/6870555700002145 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700002144 Signaling by ACTH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002144/6870555700002150 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002144 Signaling by ACTH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002144/6870555700002160 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002144 Signaling by ACTH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002144/6870555700002168 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:O43613 HCRTR1 Hsap 6870555700002216 HCRTR1 binds the neuropeptide orexin-A to regulate food behavior. (Human) NCBITaxon:9606 gomodel:6870555700002216/6870555700002217 GO:0016499 orexin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 6870555700002216 HCRTR1 binds the neuropeptide orexin-A to regulate food behavior. (Human) NCBITaxon:9606 gomodel:6870555700002216/6870555700002295 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O43612-PRO_0000020261 HCRT-Orexin-A Hsap 6870555700002216 HCRTR1 binds the neuropeptide orexin-A to regulate food behavior. (Human) NCBITaxon:9606 gomodel:6870555700002216/6870555700002585 GO:0160041 neuropeptide activity GO:0005576 extracellular region false UniProtKB:P10412 H1-4 Hsap 6870555700002306 Transcription factor CRAMP1 specifically mediates expression of histone H1 genes, enabling Polycomb repression (Human). NCBITaxon:9606 gomodel:6870555700002306/6870555700002329 GO:0030527 structural constituent of chromatin GO:0030261 chromosome condensation GO:0000792 heterochromatin false UniProtKB:Q96RY5 CRAMP1 Hsap 6870555700002306 Transcription factor CRAMP1 specifically mediates expression of histone H1 genes, enabling Polycomb repression (Human). NCBITaxon:9606 gomodel:6870555700002306/6870555700002340 GO:0003700 DNA-binding transcription factor activity GO:0045893 positive regulation of DNA-templated transcription GO:0035363 histone locus body false UniProtKB:Q15910 EZH2 Hsap 6870555700002306 Transcription factor CRAMP1 specifically mediates expression of histone H1 genes, enabling Polycomb repression (Human). NCBITaxon:9606 gomodel:6870555700002306/6870555700002355 GO:0140951 histone H3K27 trimethyltransferase activity GO:0045892 negative regulation of DNA-templated transcription GO:0000792 heterochromatin false UniProtKB:P16403 H1-2 Hsap 6870555700002365 Linker histone H1.2 recognizes and binds H3K27me3 (Human). NCBITaxon:9606 gomodel:6870555700002365/6870555700002366 GO:0030527 structural constituent of chromatin GO:0030261 chromosome condensation GO:0000792 heterochromatin false UniProtKB:Q15910 EZH2 Hsap 6870555700002365 Linker histone H1.2 recognizes and binds H3K27me3 (Human). NCBITaxon:9606 gomodel:6870555700002365/6870555700002388 GO:0140951 histone H3K27 trimethyltransferase activity GO:0045892 negative regulation of DNA-templated transcription GO:0000792 heterochromatin false UniProtKB:P16403 H1-2 Hsap 6870555700002365 Linker histone H1.2 recognizes and binds H3K27me3 (Human). NCBITaxon:9606 gomodel:6870555700002365/6870555700002399 GO:0061628 histone H3K27me3 reader activity GO:0030261 chromosome condensation GO:0000792 heterochromatin false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 6870555700002703 Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002703/6870555700002704 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700002703 Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002703/6870555700002709 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002703 Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002703/6870555700002719 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002703 Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002703/6870555700002727 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:O60291 MGRN1 Hsap 6870555700002703 Negative regulation of MC1R receptor signaling by MGRN1_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002703/6870555700003575 GO:0140311 protein sequestering activity GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO:0005829 cytosol false UniProtKB:P01189-PRO_0000024974 POMC-Beta-MSH Hsap 6870555700002749 Signaling by beta-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002749/6870555700002750 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700002749 Signaling by beta-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002749/6870555700002755 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002749 Signaling by beta-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002749/6870555700002765 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002749 Signaling by beta-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002749/6870555700002773 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024967 POMC-Melanotropin_gamma Hsap 6870555700002816 Signaling by gamma-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002816/6870555700002817 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700002816 Signaling by gamma-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002816/6870555700002822 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002816 Signaling by gamma-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002816/6870555700002832 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002816 Signaling by gamma-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002816/6870555700002840 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q01726 MC1R Hsap 6870555700002860 Negative regulation of MC1R receptor activity by Agouti_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002860/6870555700002866 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002860 Negative regulation of MC1R receptor activity by Agouti_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002860/6870555700002876 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002860 Negative regulation of MC1R receptor activity by Agouti_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002860/6870555700002884 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P42127 ASIP Hsap 6870555700002860 Negative regulation of MC1R receptor activity by Agouti_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002860/6870555700002905 GO:0048019 receptor antagonist activity GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700002918 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700002923 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700002933 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700002941 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9H1Y3 OPN3 Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700003431 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 6870555700002917 Negative regulation of MC1R receptor activity by OPN3 via G-alpha-i (inhibitory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700002917/6870555700003447 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 6870555700003497 Signaling by alpha-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700003497/6870555700003498 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01726 MC1R Hsap 6870555700003497 Signaling by alpha-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700003497/6870555700003503 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 6870555700003497 Signaling by alpha-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700003497/6870555700003513 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6870555700003497 Signaling by alpha-MSH mediated by MC1R receptor via G-alpha-s (activatory)_Melanogenesis (Human) NCBITaxon:9606 gomodel:6870555700003497/6870555700003521 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:O75426 FBXO24 Hsap 6870555700004574 FBXO24-mediated degradation of NME1(Human) NCBITaxon:9606 gomodel:6870555700004574/6870555700004575 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P15531 NME1 Hsap 6870555700004574 FBXO24-mediated degradation of NME1(Human) NCBITaxon:9606 gomodel:6870555700004574/6870555700004582 GO:0008296 3'-5'-DNA exonuclease activity GO:0009142 nucleoside triphosphate biosynthetic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 6870555700004574 FBXO24-mediated degradation of NME1(Human) NCBITaxon:9606 gomodel:6870555700004574/6870555700004589 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q92830 KAT2A Hsap 6870555700004574 FBXO24-mediated degradation of NME1(Human) NCBITaxon:9606 gomodel:6870555700004574/6870555700004602 GO:0016407 acetyltransferase activity GO:0062026 negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process GO:0005634 nucleus false UniProtKB:O75426 FBXO24 Hsap 6870555700004614 FBXO24-mediated degradation of PRMT6 (Human) NCBITaxon:9606 gomodel:6870555700004614/6870555700004615 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 6870555700004614 FBXO24-mediated degradation of PRMT6 (Human) NCBITaxon:9606 gomodel:6870555700004614/6870555700004629 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q96LA8 PRMT6 Hsap 6870555700004614 FBXO24-mediated degradation of PRMT6 (Human) NCBITaxon:9606 gomodel:6870555700004614/6870555700004652 GO:0016274 protein-arginine N-methyltransferase activity GO:0090068 positive regulation of cell cycle process GO:0005634 nucleus false UniProtKB:P18754 RCC1 Hsap 6870555700004614 FBXO24-mediated degradation of PRMT6 (Human) NCBITaxon:9606 gomodel:6870555700004614/6870555700004660 GO:0005085 guanyl-nucleotide exchange factor activity GO:0090068 positive regulation of cell cycle process GO:0005634 nucleus false UniProtKB:Q13501 SQSTM1 Hsap 6870555700004670 FBXO24 regulation of autophagy via ULK1 degradation (Human) NCBITaxon:9606 gomodel:6870555700004670/6870555700004671 GO:0140311 protein sequestering activity GO:0033554 cellular response to stress GO:0043232 intracellular membraneless organelle false UniProtKB:O75385 ULK1 Hsap 6870555700004670 FBXO24 regulation of autophagy via ULK1 degradation (Human) NCBITaxon:9606 gomodel:6870555700004670/6870555700004694 GO:0004674 protein serine/threonine kinase activity GO:0033554 cellular response to stress GO:0005737 cytoplasm false UniProtKB:Q14145 KEAP1 Hsap 6870555700004670 FBXO24 regulation of autophagy via ULK1 degradation (Human) NCBITaxon:9606 gomodel:6870555700004670/6870555700004701 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6870555700004670 FBXO24 regulation of autophagy via ULK1 degradation (Human) NCBITaxon:9606 gomodel:6870555700004670/6870555700004713 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:O75426 FBXO24 Hsap 6870555700004670 FBXO24 regulation of autophagy via ULK1 degradation (Human) NCBITaxon:9606 gomodel:6870555700004670/6870555700004720 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000043 GO:0044729 hemi-methylated DNA-binding GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0005657 replication fork false UniProtKB:Q14527 HLTF Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000050 GO:0062072 histone H3K9me2/3 reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000785 chromatin false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000057 GO:0140248 histone H3K18 ubiquitin ligase activity GO:0071168 protein localization to chromatin GO:0005657 replication fork false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000066 GO:0062072 histone H3K9me2/3 reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0005657 replication fork false UniProtKB:Q14527 HLTF Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000073 GO:0140234 histone H3K23 ubiquitin ligase activity GO:0071168 protein localization to chromatin GO:0000785 chromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000086 GO:0140254 histone H3K18ub reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000094 GO:0140257 histone H3K23ub reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:O43463 SUV39H1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000102 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000042 UHRF1 and SMARCA3 mediate histone H3 ubiquitination (H3K18ub and H3K23ub), promoting DNMT1 recruitment at hemimethylated DNA (Human). NCBITaxon:9606 gomodel:6882d2b800000042/6882d2b800000110 GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:Q96LB1 MRGPRX2 Hsap 6882d2b800000251 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000251/6882d2b800000252 GO:1990595 mast cell secretagogue receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 6882d2b800000251 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000251/6882d2b800000265 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 6882d2b800000251 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000251/6882d2b800000272 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P20366-PRO_0000033530 TAC1-Substance_P Hsap 6882d2b800000251 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3, DAG) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000251/6882d2b800000289 GO:0160041 neuropeptide activity GO:0043306 positive regulation of mast cell degranulation GO:0005576 extracellular region false UniProtKB:Q96LB1 MRGPRX2 Hsap 6882d2b800000297 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000297/6882d2b800000298 GO:1990595 mast cell secretagogue receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 6882d2b800000297 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000297/6882d2b800000299 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 6882d2b800000297 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000297/6882d2b800000300 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P20366-PRO_0000033530 TAC1-Substance_P Hsap 6882d2b800000297 Mast cell degranulation via MRGPRX2-mediated signaling via G-alpha-i (inhibitory) inhibiting adenylate cyclase) following activation by substance P (Human). NCBITaxon:9606 gomodel:6882d2b800000297/6882d2b800000331 GO:0160041 neuropeptide activity GO:0043306 positive regulation of mast cell degranulation GO:0005576 extracellular region false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000418 GO:0140248 histone H3K18 ubiquitin ligase activity GO:0071168 protein localization to chromatin GO:0005657 replication fork false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000427 GO:0062072 histone H3K9me2/3 reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0005657 replication fork false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000445 GO:0140254 histone H3K18ub reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:O43463 SUV39H1 Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000459 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000467 GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:P17612 PRKACA Hsap 6882d2b800000403 Phosphorylation of UHRF1 by PKA decreased UHRF1 binding to H3K9me3 (Human). NCBITaxon:9606 gomodel:6882d2b800000403/6882d2b800000479 GO:0004674 protein serine/threonine kinase activity GO:0120186 negative regulation of protein localization to chromatin false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000492 GO:0140248 histone H3K18 ubiquitin ligase activity GO:0071168 protein localization to chromatin GO:0005657 replication fork false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000508 GO:0140254 histone H3K18ub reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:O43463 SUV39H1 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000515 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000523 GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:Q93009 USP7 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000543 GO:0004843 cysteine-type deubiquitinase activity GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000491 USP7 mediates deubiquitination of UHRF1, preventing autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000491/6882d2b800000550 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000560 GO:0140248 histone H3K18 ubiquitin ligase activity GO:0071168 protein localization to chromatin GO:0005657 replication fork false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000569 GO:0140254 histone H3K18ub reader activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:O43463 SUV39H1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000576 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:P26358 DNMT1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000584 GO:0003886 DNA (cytosine-5-)-methyltransferase activity GO:0141119 chromosomal DNA methylation maintenance following DNA replication GO:0000792 heterochromatin false UniProtKB:Q93009 USP7 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000593 GO:0004843 cysteine-type deubiquitinase activity GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q96T88 UHRF1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000600 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:P06493 CDK1 Hsap 6882d2b800000559 Phosphorylation of UHRF1 by CDK1 prevents UHRF1 deubiquitination by USP7, promoting autoubiquitination and degradation of UHRF1 (Human). NCBITaxon:9606 gomodel:6882d2b800000559/6882d2b800000613 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process false UniProtKB:P08183 ABCB1 Hsap 6882d2b800001639 Phosphatidylethanolamine transport by ABCB1 (Human) NCBITaxon:9606 gomodel:6882d2b800001639/6882d2b800001640 GO:0140341 phosphatidylethanolamine floppase activity GO:0045332 phospholipid translocation GO:0016324 apical plasma membrane false UniProtKB:P29320 EPHA3 Hsap 6882d2b800004512 EPHA3 activation by EFNA5 in cell adhesion (Human) NCBITaxon:9606 gomodel:6882d2b800004512/6882d2b800004513 GO:0005003 ephrin receptor activity GO:0048013 ephrin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P52803 EFNA5 Hsap 6882d2b800004512 EPHA3 activation by EFNA5 in cell adhesion (Human) NCBITaxon:9606 gomodel:6882d2b800004512/6882d2b800004521 GO:0048018 receptor ligand activity GO:0048013 ephrin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P46108 CRK Hsap 6882d2b800004512 EPHA3 activation by EFNA5 in cell adhesion (Human) NCBITaxon:9606 gomodel:6882d2b800004512/6882d2b800004541 GO:0035591 signaling adaptor activity GO:0048013 ephrin receptor signaling pathway GO:0005829 cytosol false UniProtKB:P61586 RHOA Hsap 6882d2b800004512 EPHA3 activation by EFNA5 in cell adhesion (Human) NCBITaxon:9606 gomodel:6882d2b800004512/6882d2b800004551 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:Q9Y2D9 ZNF652 Hsap 689e7a5d00000052 ZNF652 and CBFA2T3 repress expression of TCF12 (Human). NCBITaxon:9606 gomodel:689e7a5d00000052/689e7a5d00000053 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0000122 negative regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:O75081 CBFA2T3 Hsap 689e7a5d00000052 ZNF652 and CBFA2T3 repress expression of TCF12 (Human). NCBITaxon:9606 gomodel:689e7a5d00000052/689e7a5d00000062 GO:0003714 transcription corepressor activity GO:0000122 negative regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q99081 TCF12 Hsap 689e7a5d00000052 ZNF652 and CBFA2T3 repress expression of TCF12 (Human). NCBITaxon:9606 gomodel:689e7a5d00000052/689e7a5d00000072 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0045944 positive regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:O00468-6 AGRN Hsap 689e7a5d00000098 Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) NCBITaxon:9606 gomodel:689e7a5d00000098/689e7a5d00000099 GO:0048018 receptor ligand activity GO:0007166 cell surface receptor signaling pathway GO:0031012 extracellular matrix false UniProtKB:Q14118-PRO_0000021065 DAG1-Alpha-DG Hsap 689e7a5d00000098 Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) NCBITaxon:9606 gomodel:689e7a5d00000098/689e7a5d00000108 GO:0038023 signaling receptor activity GO:0007166 cell surface receptor signaling pathway GO:0031012 extracellular matrix false UniProtKB:P48436 SOX9 Hsap 689e7a5d00000098 Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) NCBITaxon:9606 gomodel:689e7a5d00000098/689e7a5d00000131 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0002062 chondrocyte differentiation GO:0005634 nucleus false UniProtKB:P02458 COL2A1 Hsap 689e7a5d00000098 Alpha-dystroglycan is a receptor for agrin required for upregulation of SOX9, a transcription factor involved in chondrocyte differentiation (Human) NCBITaxon:9606 gomodel:689e7a5d00000098/689e7a5d00000701 GO:0005201 extracellular matrix structural constituent GO:0002062 chondrocyte differentiation GO:0031012 extracellular matrix false UniProtKB:Q9Y3I0 RTCB Hsap 689e7a5d00000567 Activation of XBP1 by IRE1 in UPR (Human) NCBITaxon:9606 gomodel:689e7a5d00000567/689e7a5d00000568 GO:0170057 RNA ligase (GTP) activity GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation GO:0005737 cytoplasm false UniProtKB:O75460 ERN1 Hsap 689e7a5d00000567 Activation of XBP1 by IRE1 in UPR (Human) NCBITaxon:9606 gomodel:689e7a5d00000567/689e7a5d00000580 GO:0004521 RNA endonuclease activity GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation GO:0005737 cytoplasm false UniProtKB:P11021 HSPA5 Hsap 689e7a5d00000567 Activation of XBP1 by IRE1 in UPR (Human) NCBITaxon:9606 gomodel:689e7a5d00000567/689e7a5d00000596 GO:0140311 protein sequestering activity GO:1903894 regulation of IRE1-mediated unfolded protein response GO:0005788 endoplasmic reticulum lumen false UniProtKB:P17861-2 XBP1 Hsap 689e7a5d00000567 Activation of XBP1 by IRE1 in UPR (Human) NCBITaxon:9606 gomodel:689e7a5d00000567/689e7a5d00000609 GO:0003700 DNA-binding transcription factor activity GO:0036498 IRE1-mediated unfolded protein response GO:0005634 nucleus false GO:1902494 catalytic complex 689e7a5d00000567 Activation of XBP1 by IRE1 in UPR (Human) NCBITaxon:9606 gomodel:689e7a5d00000567/689e7a5d00000627 GO:0044600 protein guanylyltransferase activity GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation GO:0005737 cytoplasm false UniProtKB:O95461 LARGE1 Hsap 689e7a5d00000901 Post-translational modification-dependent alpha-dystroglycan interaction with pikachurin (EGFLAM) is required for ribbon synapse formation (Human) NCBITaxon:9606 gomodel:689e7a5d00000901/689e7a5d00000920 GO:0015020 glucuronosyltransferase activity GO:0035269 protein O-linked glycosylation via mannose GO:0005794 Golgi apparatus false UniProtKB:Q63HQ2 EGFLAM Hsap 689e7a5d00000901 Post-translational modification-dependent alpha-dystroglycan interaction with pikachurin (EGFLAM) is required for ribbon synapse formation (Human) NCBITaxon:9606 gomodel:689e7a5d00000901/689e7a5d00001590 GO:0060090 molecular adaptor activity GO:0007416 synapse assembly GO:0098684 photoreceptor ribbon synapse false UniProtKB:Q6PRD1 GPR179 Hsap 689e7a5d00000901 Post-translational modification-dependent alpha-dystroglycan interaction with pikachurin (EGFLAM) is required for ribbon synapse formation (Human) NCBITaxon:9606 gomodel:689e7a5d00000901/689e7a5d00002940 GO:0043495 protein-membrane adaptor activity GO:0072659 protein localization to plasma membrane GO:0044292 dendrite terminus false UniProtKB:Q9H4M3 FBXO44 Hsap 689e7a5d00003489 FBXO44-mediated degradation of RGS2 via CUL4B/DDB1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00003489/689e7a5d00003499 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P41220 RGS2 Hsap 689e7a5d00003489 FBXO44-mediated degradation of RGS2 via CUL4B/DDB1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00003489/689e7a5d00004062 GO:0005096 GTPase activator activity GO:0008277 regulation of G protein-coupled receptor signaling pathway GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 689e7a5d00003489 FBXO44-mediated degradation of RGS2 via CUL4B/DDB1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00003489/689e7a5d00004071 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false GO:0032991 protein-containing complex 689e7a5d00003489 FBXO44-mediated degradation of RGS2 via CUL4B/DDB1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00003489/689e7a5d00004189 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P29317 EPHA2 Hsap 689e7a5d00003515 Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) NCBITaxon:9606 gomodel:689e7a5d00003515/689e7a5d00003516 GO:0005003 ephrin receptor activity GO:0048013 ephrin receptor signaling pathway GO:0005925 focal adhesion false UniProtKB:P20827 EFNA1 Hsap 689e7a5d00003515 Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) NCBITaxon:9606 gomodel:689e7a5d00003515/689e7a5d00003519 GO:0048018 receptor ligand activity GO:0048013 ephrin receptor signaling pathway GO:0005925 focal adhesion false UniProtKB:Q06124 PTPN11 Hsap 689e7a5d00003515 Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) NCBITaxon:9606 gomodel:689e7a5d00003515/689e7a5d00003784 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0048013 ephrin receptor signaling pathway GO:0005925 focal adhesion false UniProtKB:Q05397 PTK2 Hsap 689e7a5d00003515 Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) NCBITaxon:9606 gomodel:689e7a5d00003515/689e7a5d00003800 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0033634 positive regulation of cell-cell adhesion mediated by integrin GO:0005925 focal adhesion false UniProtKB:P05556 ITGB1 Hsap 689e7a5d00003515 Ephrin-A1/EPHA2 negative regulation of cell adhesion mediated by integrin (Human) NCBITaxon:9606 gomodel:689e7a5d00003515/689e7a5d00003868 GO:0004895 cell adhesion receptor activity GO:0007229 integrin-mediated signaling pathway GO:0005925 focal adhesion false UniProtKB:O43613 HCRTR1 Hsap 689e7a5d00003524 HCRTR1 binds the neuropeptide orexin-B to regulate food behavior. (Human) NCBITaxon:9606 gomodel:689e7a5d00003524/689e7a5d00003525 GO:0016499 orexin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 689e7a5d00003524 HCRTR1 binds the neuropeptide orexin-B to regulate food behavior. (Human) NCBITaxon:9606 gomodel:689e7a5d00003524/689e7a5d00003529 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O43612-PRO_0000020262 HCRT-Orexin-B Hsap 689e7a5d00003524 HCRTR1 binds the neuropeptide orexin-B to regulate food behavior. (Human) NCBITaxon:9606 gomodel:689e7a5d00003524/689e7a5d00003608 GO:0160041 neuropeptide activity GO:0005576 extracellular region false UniProtKB:P20366-PRO_0000033530 TAC1-Substance_P Hsap 689e7a5d00003704 Substance P binding to NK1 receptor triggers phospholipase C-activating G protein-coupled receptor signaling (Human) NCBITaxon:9606 gomodel:689e7a5d00003704/689e7a5d00005789 GO:0048018 receptor ligand activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 689e7a5d00003704 Substance P binding to NK1 receptor triggers phospholipase C-activating G protein-coupled receptor signaling (Human) NCBITaxon:9606 gomodel:689e7a5d00003704/68b0f0d000009154 GO:0003925 G protein activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P25103 TACR1 Hsap 689e7a5d00003704 Substance P binding to NK1 receptor triggers phospholipase C-activating G protein-coupled receptor signaling (Human) NCBITaxon:9606 gomodel:689e7a5d00003704/68b0f0d000009163 GO:0016496 substance P receptor activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9NRX3 COXFA4L2 Hsap 689e7a5d00004061 Regulation of Respiratory chain complex I by COXFA4L2 upon hypoxia. (Human) NCBITaxon:9606 gomodel:689e7a5d00004061/689e7a5d00004259 GO:0004857 enzyme inhibitor activity GO:0071456 cellular response to hypoxia GO:0005739 mitochondrion false UniProtKB:Q16665 HIF1A Hsap 689e7a5d00004061 Regulation of Respiratory chain complex I by COXFA4L2 upon hypoxia. (Human) NCBITaxon:9606 gomodel:689e7a5d00004061/689e7a5d00004268 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0071456 cellular response to hypoxia GO:0005634 nucleus false GO:0045271 respiratory chain complex I 689e7a5d00004061 Regulation of Respiratory chain complex I by COXFA4L2 upon hypoxia. (Human) NCBITaxon:9606 gomodel:689e7a5d00004061/689e7a5d00004278 GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0071456 cellular response to hypoxia GO:0005743 mitochondrial inner membrane false UniProtKB:Q9H4M3 FBXO44 Hsap 689e7a5d00004202 FBXO44-mediated degradation of BRCA1 via CUL1/SKP1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00004202/689e7a5d00004203 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 689e7a5d00004202 FBXO44-mediated degradation of BRCA1 via CUL1/SKP1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00004202/689e7a5d00004217 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P38398 BRCA1 Hsap 689e7a5d00004202 FBXO44-mediated degradation of BRCA1 via CUL1/SKP1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00004202/689e7a5d00004243 GO:0004842 ubiquitin-protein transferase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q13616 CUL1 Hsap 689e7a5d00004202 FBXO44-mediated degradation of BRCA1 via CUL1/SKP1 complex (Human) NCBITaxon:9606 gomodel:689e7a5d00004202/6a18a9ba00003283 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 689e7a5d00004366 Signaling by ACTH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004366/689e7a5d00004367 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32245 MC4R Hsap 689e7a5d00004366 Signaling by ACTH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004366/689e7a5d00004372 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00004366 Signaling by ACTH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004366/689e7a5d00004382 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00004366 Signaling by ACTH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004366/689e7a5d00004390 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q16665 HIF1A Hsap 689e7a5d00004412 Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) NCBITaxon:9606 gomodel:689e7a5d00004412/689e7a5d00004413 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:0005634 nucleus false GO:0045271 respiratory chain complex I 689e7a5d00004412 Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) NCBITaxon:9606 gomodel:689e7a5d00004412/689e7a5d00004425 GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:1903409 reactive oxygen species biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P17861-2 XBP1 Hsap 689e7a5d00004412 Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) NCBITaxon:9606 gomodel:689e7a5d00004412/689e7a5d00004431 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:1900017 positive regulation of cytokine production involved in inflammatory response GO:0005634 nucleus false UniProtKB:Q9NRX3 COXFA4L2 Hsap 689e7a5d00004412 Lactate regulates dendritic cell function trhough ROS production inhibition by COXFA4L2. (Human) NCBITaxon:9606 gomodel:689e7a5d00004412/69d8496c00005719 GO:0004857 enzyme inhibitor activity GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:0005739 mitochondrion false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 689e7a5d00004460 Signaling by alpha-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004460/689e7a5d00004461 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32245 MC4R Hsap 689e7a5d00004460 Signaling by alpha-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004460/689e7a5d00004466 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00004460 Signaling by alpha-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004460/689e7a5d00004474 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00004460 Signaling by alpha-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004460/689e7a5d00004482 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P01189-PRO_0000024974 POMC-Beta-MSH Hsap 689e7a5d00004800 Signaling by beta-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004800/689e7a5d00004801 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32245 MC4R Hsap 689e7a5d00004800 Signaling by beta-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004800/689e7a5d00004806 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00004800 Signaling by beta-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004800/689e7a5d00004814 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00004800 Signaling by beta-MSH mediated by MC4R receptor via G-alpha-s (activatory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004800/689e7a5d00004822 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P32245 MC4R Hsap 689e7a5d00004884 Negative regulation of MC4R receptor activity by AgoutiRP_ Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004884/689e7a5d00004885 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00004884 Negative regulation of MC4R receptor activity by AgoutiRP_ Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004884/689e7a5d00004894 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00004884 Negative regulation of MC4R receptor activity by AgoutiRP_ Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004884/689e7a5d00004902 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:O00253 AGRP Hsap 689e7a5d00004884 Negative regulation of MC4R receptor activity by AgoutiRP_ Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004884/689e7a5d00004916 GO:0048019 receptor antagonist activity GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 689e7a5d00004928 Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004928/689e7a5d00004929 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32245 MC4R Hsap 689e7a5d00004928 Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004928/689e7a5d00004934 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00004928 Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004928/689e7a5d00004944 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00004928 Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004928/689e7a5d00004952 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:O60291 MGRN1 Hsap 689e7a5d00004928 Negative regulation of MC4R receptor signaling by MGRN1_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00004928/689e7a5d00004973 GO:0140311 protein sequestering activity GO:0045744 negative regulation of G protein-coupled receptor signaling pathway GO:0005829 cytosol false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005053 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32245 MC4R Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005058 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005066 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005074 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9H1Y3 OPN3 Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005153 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 689e7a5d00005052 Negative regulation of MC4R receptor activity by OPN3 via G-alpha-i (inhibitory)_Food intake (Human) NCBITaxon:9606 gomodel:689e7a5d00005052/689e7a5d00005164 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9H1Y3 OPN3 Hsap 689e7a5d00005183 Positive regulation of KCNJ13 channel by OPN3 via G-alpha-i (inhibitory)_Membrane potential (Human) NCBITaxon:9606 gomodel:689e7a5d00005183/689e7a5d00005225 GO:0004930 G protein-coupled receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 689e7a5d00005183 Positive regulation of KCNJ13 channel by OPN3 via G-alpha-i (inhibitory)_Membrane potential (Human) NCBITaxon:9606 gomodel:689e7a5d00005183/689e7a5d00005236 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60928 KCNJ13 Hsap 689e7a5d00005183 Positive regulation of KCNJ13 channel by OPN3 via G-alpha-i (inhibitory)_Membrane potential (Human) NCBITaxon:9606 gomodel:689e7a5d00005183/689e7a5d00005249 GO:0005242 inward rectifier potassium channel activity GO:0006813 potassium ion transport GO:0005886 plasma membrane false UniProtKB:Q14849 STARD3 Hsap 689e7a5d00005283 Cholesterol transport in ER-Endosome MCS enabled by STARD3 (Human) NCBITaxon:9606 gomodel:689e7a5d00005283/689e7a5d00005284 GO:0120020 cholesterol transfer activity GO:0030301 cholesterol transport GO:0140284 endoplasmic reticulum-endosome membrane contact site false UniProtKB:Q96DR4 STARD4 Hsap 689e7a5d00005311 Cholesterol transport from PM to ER by STARD4 (Human) NCBITaxon:9606 gomodel:689e7a5d00005311/689e7a5d00005312 GO:0120020 cholesterol transfer activity GO:0070508 cholesterol import GO:0005737 cytoplasm false UniProtKB:Q96JA3 PLEKHA8 Hsap 689e7a5d00005750 SL biosynthesis: Glycolipid transport by PLEKHA8 RHEA:77263 (Human) NCBITaxon:9606 gomodel:689e7a5d00005750/689e7a5d00005751 GO:0140340 cerebroside transfer activity GO:0046836 glycolipid transport GO:0005829 cytosol false UniProtKB:P84077 ARF1 Hsap 689e7a5d00005750 SL biosynthesis: Glycolipid transport by PLEKHA8 RHEA:77263 (Human) NCBITaxon:9606 gomodel:689e7a5d00005750/68fac5ed00000517 GO:0003925 G protein activity GO:1903292 protein localization to Golgi membrane GO:0160281 cytoplasmic side of trans-Golgi network membrane false UniProtKB:Q9UBF8 PI4KB Hsap 689e7a5d00005750 SL biosynthesis: Glycolipid transport by PLEKHA8 RHEA:77263 (Human) NCBITaxon:9606 gomodel:689e7a5d00005750/68fac5ed00000561 GO:0004430 1-phosphatidylinositol 4-kinase activity GO:0160281 cytoplasmic side of trans-Golgi network membrane false UniProtKB:Q9UK61 TASOR Hsap 68b0f0d000000047 The HUSH complex mediates silencing of transposable elements (Human). NCBITaxon:9606 gomodel:68b0f0d000000047/68b0f0d000000059 GO:0030674 protein-macromolecule adaptor activity GO:0097355 protein localization to heterochromatin GO:0000792 heterochromatin false UniProtKB:Q99549 MPHOSPH8 Hsap 68b0f0d000000047 The HUSH complex mediates silencing of transposable elements (Human). NCBITaxon:9606 gomodel:68b0f0d000000047/68b0f0d000000068 GO:0062072 histone H3K9me2/3 reader activity GO:0141005 transposable element silencing by heterochromatin formation GO:0000792 heterochromatin false UniProtKB:Q8NEY8 PPHLN1 Hsap 68b0f0d000000047 The HUSH complex mediates silencing of transposable elements (Human). NCBITaxon:9606 gomodel:68b0f0d000000047/68b0f0d000000080 GO:0003729 mRNA binding GO:0141005 transposable element silencing by heterochromatin formation GO:0000792 heterochromatin false UniProtKB:Q9Y6X9 MORC2 Hsap 68b0f0d000000047 The HUSH complex mediates silencing of transposable elements (Human). NCBITaxon:9606 gomodel:68b0f0d000000047/68b0f0d000000093 GO:0140658 ATP-dependent chromatin remodeler activity GO:0141005 transposable element silencing by heterochromatin formation GO:0000792 heterochromatin false UniProtKB:Q15047 SETDB1 Hsap 68b0f0d000000047 The HUSH complex mediates silencing of transposable elements (Human). NCBITaxon:9606 gomodel:68b0f0d000000047/68b0f0d000000104 GO:0140949 histone H3K9 trimethyltransferase activity GO:0141005 transposable element silencing by heterochromatin formation GO:0000785 chromatin false UniProtKB:Q9BYX4 IFIH1 Hsap 68b0f0d000000123 The HUSH2 complex mediates epigenetic repression of interferon-stimulated genes. (Human). NCBITaxon:9606 gomodel:68b0f0d000000123/68b0f0d000000124 GO:0038187 pattern recognition receptor activity GO:0045087 innate immune response GO:0005737 cytoplasm false UniProtKB:Q5VWN6 TASOR2 Hsap 68b0f0d000000123 The HUSH2 complex mediates epigenetic repression of interferon-stimulated genes. (Human). NCBITaxon:9606 gomodel:68b0f0d000000123/68b0f0d000000163 GO:0030674 protein-macromolecule adaptor activity GO:0045814 negative regulation of gene expression, epigenetic GO:0000785 chromatin false UniProtKB:P14316 IRF2 Hsap 68b0f0d000000123 The HUSH2 complex mediates epigenetic repression of interferon-stimulated genes. (Human). NCBITaxon:9606 gomodel:68b0f0d000000123/68b0f0d000000172 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0000122 negative regulation of transcription by RNA polymerase II GO:0000785 chromatin false UniProtKB:P21854 CD72 Hsap 68b0f0d000000486 Negative regulation of BCR signaling by CD72-CD5 interaction (Human) NCBITaxon:9606 gomodel:68b0f0d000000486/68b0f0d000000487 GO:0048018 receptor ligand activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06127 CD5 Hsap 68b0f0d000000486 Negative regulation of BCR signaling by CD72-CD5 interaction (Human) NCBITaxon:9606 gomodel:68b0f0d000000486/68b0f0d000000494 GO:0038023 signaling receptor activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P07948 LYN Hsap 68b0f0d000000486 Negative regulation of BCR signaling by CD72-CD5 interaction (Human) NCBITaxon:9606 gomodel:68b0f0d000000486/68b0f0d000000506 GO:0004713 protein tyrosine kinase activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005829 cytosol false UniProtKB:P29350 PTPN6 Hsap 68b0f0d000000486 Negative regulation of BCR signaling by CD72-CD5 interaction (Human) NCBITaxon:9606 gomodel:68b0f0d000000486/68b0f0d000000513 GO:0004725 protein tyrosine phosphatase activity GO:0050859 negative regulation of B cell receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P06239 LCK Hsap 68b0f0d000000625 Galectin-9-CD44 pair leading to NK cell activation (Human) NCBITaxon:9606 gomodel:68b0f0d000000625/68b0f0d000000655 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0051132 NK T cell activation GO:0005737 cytoplasm false UniProtKB:P16070 CD44 Hsap 68b0f0d000000625 Galectin-9-CD44 pair leading to NK cell activation (Human) NCBITaxon:9606 gomodel:68b0f0d000000625/68b0f0d000001051 GO:0038023 signaling receptor activity GO:0051132 NK T cell activation GO:0005886 plasma membrane false UniProtKB:O00182 LGALS9 Hsap 68b0f0d000000625 Galectin-9-CD44 pair leading to NK cell activation (Human) NCBITaxon:9606 gomodel:68b0f0d000000625/68b0f0d000001058 GO:0048018 receptor ligand activity GO:0051132 NK T cell activation GO:0005576 extracellular region false UniProtKB:P06239 LCK Hsap 68b0f0d000001117 CD31-CD38 activation of T cells (Human) NCBITaxon:9606 gomodel:68b0f0d000001117/68b0f0d000001147 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0042110 T cell activation GO:0005737 cytoplasm false UniProtKB:P43403 ZAP70 Hsap 68b0f0d000001117 CD31-CD38 activation of T cells (Human) NCBITaxon:9606 gomodel:68b0f0d000001117/68b0f0d000001169 GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0042110 T cell activation GO:0005737 cytoplasm false UniProtKB:O43561 LAT Hsap 68b0f0d000001117 CD31-CD38 activation of T cells (Human) NCBITaxon:9606 gomodel:68b0f0d000001117/68b0f0d000001181 GO:0035591 signaling adaptor activity GO:0043410 positive regulation of MAPK cascade GO:0005886 plasma membrane false UniProtKB:P16284 PECAM1 Hsap 68b0f0d000001117 CD31-CD38 activation of T cells (Human) NCBITaxon:9606 gomodel:68b0f0d000001117/68b0f0d000001484 GO:0048018 receptor ligand activity GO:0042110 T cell activation GO:0005886 plasma membrane false UniProtKB:P28907 CD38 Hsap 68b0f0d000001117 CD31-CD38 activation of T cells (Human) NCBITaxon:9606 gomodel:68b0f0d000001117/68b0f0d000001493 GO:0038023 signaling receptor activity GO:0042110 T cell activation GO:0005886 plasma membrane false GO:0017059 serine palmitoyltransferase complex 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001212 GO:0004758 serine C-palmitoyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:Q06136 KDSR Hsap 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001235 GO:0047560 3-dehydrosphinganine reductase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:P27544 CERS1 Hsap 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001242 GO:0050291 sphingosine N-acyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:O15121 DEGS1 Hsap 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001253 GO:0042284 sphingolipid delta-4 desaturase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q9Y5P4 CERT1 Hsap 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001264 GO:0120017 ceramide transfer activity GO:0006686 sphingomyelin biosynthetic process GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q86VZ5 SGMS1 Hsap 68b0f0d000001211 De novo sphingomyelin biosynthesis (CerS1) NCBITaxon:9606 gomodel:68b0f0d000001211/68b0f0d000001276 GO:0033188 sphingomyelin synthase activity GO:0006686 sphingomyelin biosynthetic process GO:1990676 Golgi trans cisterna membrane false UniProtKB:P63208 SKP1 Hsap 68b0f0d000002100 RAB27A degradation in a FBXO28-dependent manner (Human) NCBITaxon:9606 gomodel:68b0f0d000002100/68b0f0d000002108 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q13616 CUL1 Hsap 68b0f0d000002100 RAB27A degradation in a FBXO28-dependent manner (Human) NCBITaxon:9606 gomodel:68b0f0d000002100/68b0f0d000002115 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9NVF7 FBXO28 Hsap 68b0f0d000002100 RAB27A degradation in a FBXO28-dependent manner (Human) NCBITaxon:9606 gomodel:68b0f0d000002100/68b0f0d000002134 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 68b0f0d000002100 RAB27A degradation in a FBXO28-dependent manner (Human) NCBITaxon:9606 gomodel:68b0f0d000002100/68b0f0d000002141 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P51159 RAB27A Hsap 68b0f0d000002100 RAB27A degradation in a FBXO28-dependent manner (Human) NCBITaxon:9606 gomodel:68b0f0d000002100/68b0f0d000002178 GO:0003924 GTPase activity GO:0006887 exocytosis GO:0070382 exocytic vesicle false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 68b0f0d000002640 Signaling by ACTH mediated by MC2R receptor via G-alpha-s (activatory)_Glucocorticoid biosynthesis (Human) NCBITaxon:9606 gomodel:68b0f0d000002640/68b0f0d000002641 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01718 MC2R Hsap 68b0f0d000002640 Signaling by ACTH mediated by MC2R receptor via G-alpha-s (activatory)_Glucocorticoid biosynthesis (Human) NCBITaxon:9606 gomodel:68b0f0d000002640/68b0f0d000002646 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000002640 Signaling by ACTH mediated by MC2R receptor via G-alpha-s (activatory)_Glucocorticoid biosynthesis (Human) NCBITaxon:9606 gomodel:68b0f0d000002640/68b0f0d000002656 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002640 Signaling by ACTH mediated by MC2R receptor via G-alpha-s (activatory)_Glucocorticoid biosynthesis (Human) NCBITaxon:9606 gomodel:68b0f0d000002640/68b0f0d000002664 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 68b0f0d000002686 Signaling by ACTH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002686/68b0f0d000002687 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41968 MC3R Hsap 68b0f0d000002686 Signaling by ACTH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002686/68b0f0d000002692 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000002686 Signaling by ACTH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002686/68b0f0d000002700 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002686 Signaling by ACTH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002686/68b0f0d000002708 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P0DMS8 ADORA3 Hsap 68b0f0d000002755 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by adenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002755/68b0f0d000002756 GO:0001609 G protein-coupled adenosine receptor activity GO:0008016 regulation of heart contraction GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002755 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by adenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002755/68b0f0d000002757 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 68b0f0d000002755 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by adenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002755/68b0f0d000002758 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P0DMS8 ADORA3 Hsap 68b0f0d000002796 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002796/68b0f0d000002797 GO:0001609 G protein-coupled adenosine receptor activity GO:0043306 positive regulation of mast cell degranulation GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002796 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002796/68b0f0d000002798 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 68b0f0d000002796 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002796/68b0f0d000002799 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q8IZH2 XRN1 Hsap 68b0f0d000002796 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002796/68b0f0d000002832 GO:0004534 5'-3' RNA exonuclease activity GO:0006402 mRNA catabolic process false UniProtKB:Q86U44 METTL3 Hsap 68b0f0d000002796 ADORA3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by N(6)-methyladenosine (Human). NCBITaxon:9606 gomodel:68b0f0d000002796/68b0f0d000002838 GO:0001734 mRNA m(6)A methyltransferase activity GO:0016556 mRNA modification false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 68b0f0d000002848 Signaling by alpha-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002848/68b0f0d000002849 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41968 MC3R Hsap 68b0f0d000002848 Signaling by alpha-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002848/68b0f0d000002854 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000002848 Signaling by alpha-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002848/68b0f0d000002862 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002848 Signaling by alpha-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002848/68b0f0d000002870 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024974 POMC-Beta-MSH Hsap 68b0f0d000002890 Signaling by beta-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002890/68b0f0d000002891 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41968 MC3R Hsap 68b0f0d000002890 Signaling by beta-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002890/68b0f0d000002896 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000002890 Signaling by beta-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002890/68b0f0d000002904 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002890 Signaling by beta-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002890/68b0f0d000002912 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024967 POMC-Melanotropin_gamma Hsap 68b0f0d000002932 Signaling by gamma-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002932/68b0f0d000002933 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41968 MC3R Hsap 68b0f0d000002932 Signaling by gamma-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002932/68b0f0d000002938 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000002932 Signaling by gamma-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002932/68b0f0d000002946 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000002932 Signaling by gamma-MSH mediated by MC3R receptor via G-alpha-s (activatory)_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000002932/68b0f0d000002954 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:O00253 AGRP Hsap 68b0f0d000003050 Negative regulation of MC3R receptor by AgoutiRP_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000003050/68b0f0d000003051 GO:0048019 receptor antagonist activity GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P41968 MC3R Hsap 68b0f0d000003050 Negative regulation of MC3R receptor by AgoutiRP_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000003050/68b0f0d000003056 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000003050 Negative regulation of MC3R receptor by AgoutiRP_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000003050/68b0f0d000003064 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000003050 Negative regulation of MC3R receptor by AgoutiRP_Feeding bevaviour (Human) NCBITaxon:9606 gomodel:68b0f0d000003050/68b0f0d000003072 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 68b0f0d000003135 Signaling by ACTH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003135/68b0f0d000003136 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P33032 MC5R Hsap 68b0f0d000003135 Signaling by ACTH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003135/68b0f0d000003141 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000003135 Signaling by ACTH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003135/68b0f0d000003149 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000003135 Signaling by ACTH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003135/68b0f0d000003157 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 68b0f0d000003216 Signaling by alpha-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003216/68b0f0d000003217 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P33032 MC5R Hsap 68b0f0d000003216 Signaling by alpha-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003216/68b0f0d000003222 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000003216 Signaling by alpha-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003216/68b0f0d000003230 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000003216 Signaling by alpha-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003216/68b0f0d000003238 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024970 POMC-Alpha-MSH Hsap 68b0f0d000003260 Signaling by alpha-MSH mediated by MC5R receptor via ERK1/2_Immunosuppression (Human) NCBITaxon:9606 gomodel:68b0f0d000003260/68b0f0d000003261 GO:0048018 receptor ligand activity GO:0007165 signal transduction GO:0005576 extracellular region false UniProtKB:P33032 MC5R Hsap 68b0f0d000003260 Signaling by alpha-MSH mediated by MC5R receptor via ERK1/2_Immunosuppression (Human) NCBITaxon:9606 gomodel:68b0f0d000003260/68b0f0d000003266 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007165 signal transduction GO:0005886 plasma membrane false UniProtKB:P28482 MAPK1 Hsap 68b0f0d000003260 Signaling by alpha-MSH mediated by MC5R receptor via ERK1/2_Immunosuppression (Human) NCBITaxon:9606 gomodel:68b0f0d000003260/68b0f0d000003304 GO:0004674 protein serine/threonine kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:P27361 MAPK3 Hsap 68b0f0d000003260 Signaling by alpha-MSH mediated by MC5R receptor via ERK1/2_Immunosuppression (Human) NCBITaxon:9606 gomodel:68b0f0d000003260/68b0f0d000003312 GO:0004707 MAP kinase activity GO:0070371 ERK1 and ERK2 cascade GO:0005737 cytoplasm false UniProtKB:P01189-PRO_0000024974 POMC-Beta-MSH Hsap 68b0f0d000003320 Signaling by beta-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003320/68b0f0d000003321 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P33032 MC5R Hsap 68b0f0d000003320 Signaling by beta-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003320/68b0f0d000003326 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000003320 Signaling by beta-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003320/68b0f0d000003334 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000003320 Signaling by beta-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003320/68b0f0d000003342 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P01189-PRO_0000024967 POMC-Melanotropin_gamma Hsap 68b0f0d000003364 Signaling by gamma-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003364/68b0f0d000003365 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P33032 MC5R Hsap 68b0f0d000003364 Signaling by gamma-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003364/68b0f0d000003370 GO:0004980 melanocyte-stimulating hormone receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000003364 Signaling by gamma-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003364/68b0f0d000003378 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68b0f0d000003364 Signaling by gamma-MSH mediated by MC5R receptor via G-alpha-s (activatory)_Exocrine gland function (Human) NCBITaxon:9606 gomodel:68b0f0d000003364/68b0f0d000003386 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P21127 CDK11B Hsap 68b0f0d000003584 CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 (Human). NCBITaxon:9606 gomodel:68b0f0d000003584/68b0f0d000003585 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0048024 regulation of mRNA splicing, via spliceosome GO:0016607 nuclear speck false UniProtKB:Q96S94 CCNL2 Hsap 68b0f0d000003584 CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 (Human). NCBITaxon:9606 gomodel:68b0f0d000003584/68b0f0d000003594 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0048024 regulation of mRNA splicing, via spliceosome GO:0016607 nuclear speck false UniProtKB:Q9UHR5 SAP30BP Hsap 68b0f0d000003584 CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 (Human). NCBITaxon:9606 gomodel:68b0f0d000003584/68b0f0d000003605 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0048024 regulation of mRNA splicing, via spliceosome GO:0016607 nuclear speck false UniProtKB:O75533 SF3B1 Hsap 68b0f0d000003584 CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 (Human). NCBITaxon:9606 gomodel:68b0f0d000003584/68b0f0d000003619 GO:0036002 pre-mRNA binding GO:0000245 spliceosomal complex assembly GO:0016607 nuclear speck false UniProtKB:Q8IZH2 XRN1 Hsap 68b0f0d000003631 Detoxification of N(6)-methyladenosine by ADK and MAPDA/ADAL (Human). NCBITaxon:9606 gomodel:68b0f0d000003631/68b0f0d000003666 GO:0004534 5'-3' RNA exonuclease activity GO:0006402 mRNA catabolic process false UniProtKB:Q86U44 METTL3 Hsap 68b0f0d000003631 Detoxification of N(6)-methyladenosine by ADK and MAPDA/ADAL (Human). NCBITaxon:9606 gomodel:68b0f0d000003631/68b0f0d000003672 GO:0001734 mRNA m(6)A methyltransferase activity GO:0016556 mRNA modification false UniProtKB:P55263 ADK Hsap 68b0f0d000003631 Detoxification of N(6)-methyladenosine by ADK and MAPDA/ADAL (Human). NCBITaxon:9606 gomodel:68b0f0d000003631/68b0f0d000003681 GO:0004001 adenosine kinase activity GO:0110052 toxic metabolite repair GO:0005829 cytosol false UniProtKB:Q6DHV7 MAPDA Hsap 68b0f0d000003631 Detoxification of N(6)-methyladenosine by ADK and MAPDA/ADAL (Human). NCBITaxon:9606 gomodel:68b0f0d000003631/68b0f0d000003693 GO:0062154 N6-methyl-AMP deaminase activity GO:0110052 toxic metabolite repair GO:0005829 cytosol false UniProtKB:Q8IZH2 XRN1 Hsap 68b0f0d000003705 N(6)-methyl-AMP is an inhibitor of AMP-activated protein kinase (Human). NCBITaxon:9606 gomodel:68b0f0d000003705/68b0f0d000003709 GO:0004534 5'-3' RNA exonuclease activity GO:0006402 mRNA catabolic process false UniProtKB:Q86U44 METTL3 Hsap 68b0f0d000003705 N(6)-methyl-AMP is an inhibitor of AMP-activated protein kinase (Human). NCBITaxon:9606 gomodel:68b0f0d000003705/68b0f0d000003715 GO:0001734 mRNA m(6)A methyltransferase activity GO:0016556 mRNA modification false UniProtKB:P55263 ADK Hsap 68b0f0d000003705 N(6)-methyl-AMP is an inhibitor of AMP-activated protein kinase (Human). NCBITaxon:9606 gomodel:68b0f0d000003705/68b0f0d000003724 GO:0004001 adenosine kinase activity GO:0110052 toxic metabolite repair GO:0005829 cytosol false UniProtKB:Q13131 PRKAA1 Hsap 68b0f0d000003705 N(6)-methyl-AMP is an inhibitor of AMP-activated protein kinase (Human). NCBITaxon:9606 gomodel:68b0f0d000003705/68b0f0d000003748 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P50750 CDK9 Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004180 GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity GO:0032968 positive regulation of transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:P50750 CDK9 Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004189 GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0032968 positive regulation of transcription elongation by RNA polymerase II GO:0005634 nucleus false UniProtKB:P18615 NELFE Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004198 GO:0003729 mRNA binding GO:0160239 transcription pausing by RNA polymerase II GO:0005634 nucleus false UniProtKB:P18615 NELFE Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004205 GO:0003682 chromatin binding GO:0034244 negative regulation of transcription elongation by RNA polymerase II GO:0000785 chromatin false UniProtKB:P24928 POLR2A Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004221 GO:0003899 DNA-directed RNA polymerase activity GO:0006366 transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P21127 CDK11B Hsap 68b0f0d000004152 CDK11 regulates a RNA polymerase II pause-checkpoint upstream of CDK9 (Human) NCBITaxon:9606 gomodel:68b0f0d000004152/68b0f0d000004240 GO:0140834 RNA polymerase II CTD heptapeptide repeat S2 kinase activity GO:0001111 RNA polymerase II promoter clearance GO:0005694 chromosome false GO:0017059 serine palmitoyltransferase complex 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004297 GO:0004758 serine C-palmitoyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:Q06136 KDSR Hsap 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004320 GO:0047560 3-dehydrosphinganine reductase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q8N5B7 CERS5 Hsap 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004327 GO:0050291 sphingosine N-acyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:O15121 DEGS1 Hsap 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004338 GO:0042284 sphingolipid delta-4 desaturase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q9Y5P4 CERT1 Hsap 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004349 GO:0120017 ceramide transfer activity GO:0006686 sphingomyelin biosynthetic process GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q86VZ5 SGMS1 Hsap 68b0f0d000004290 De novo sphingomyelin synthesis (Human) CerS5 NCBITaxon:9606 gomodel:68b0f0d000004290/68b0f0d000004361 GO:0033188 sphingomyelin synthase activity GO:0006686 sphingomyelin biosynthetic process GO:1990676 Golgi trans cisterna membrane false UniProtKB:Q9P2K8 EIF2AK4 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005303 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity GO:0140469 GCN2-mediated signaling GO:0005829 cytosol false UniProtKB:P05198 EIF2S1 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005308 GO:0160296 cap-dependent translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q92616 GCN1 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005319 GO:0170011 stalled ribosome sensor activity GO:0072344 rescue of stalled cytosolic ribosome GO:0022626 cytosolic ribosome false UniProtKB:P05198 EIF2S1 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005327 GO:0160297 IRES-mediated translation initiation factor activity GO:0006413 translational initiation GO:0005829 cytosol false UniProtKB:Q8N5U6 RNF10 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005353 GO:0061630 ubiquitin protein ligase activity GO:0006513 protein monoubiquitination GO:0022626 cytosolic ribosome false UniProtKB:O14730 RIOK3 Hsap 68b0f0d000005302 Activation of the kinase activity of EIF2AK4/GCN2 in response to ribosome stalling leads to monoubiquitination of RPS2/us5 and RPS3/us3, followed by activation of RIOK3 and degradation of the 40S ribosome (Human) NCBITaxon:9606 gomodel:68b0f0d000005302/68b0f0d000005373 GO:0004674 protein serine/threonine kinase activity GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process GO:0022626 cytosolic ribosome false GO:0017059 serine palmitoyltransferase complex 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005575 GO:0004758 serine C-palmitoyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:Q06136 KDSR Hsap 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005598 GO:0047560 3-dehydrosphinganine reductase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q9HA82 CERS4 Hsap 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005605 GO:0050291 sphingosine N-acyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:O15121 DEGS1 Hsap 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005616 GO:0042284 sphingolipid delta-4 desaturase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q9Y5P4 CERT1 Hsap 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005627 GO:0120017 ceramide transfer activity GO:0006686 sphingomyelin biosynthetic process GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q86VZ5 SGMS1 Hsap 68b0f0d000005568 De novo sphingomyelin synthesis (Human) CerS4 NCBITaxon:9606 gomodel:68b0f0d000005568/68b0f0d000005639 GO:0033188 sphingomyelin synthase activity GO:0006686 sphingomyelin biosynthetic process GO:1990676 Golgi trans cisterna membrane false UniProtKB:Q13618 CUL3 Hsap 68b0f0d000006733 CUL3/LZTR1/RBX1 complex ubiquitinates HRAS leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:68b0f0d000006733/68b0f0d000006738 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005794 Golgi apparatus false UniProtKB:P62877 RBX1 Hsap 68b0f0d000006733 CUL3/LZTR1/RBX1 complex ubiquitinates HRAS leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:68b0f0d000006733/68b0f0d000006749 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005794 Golgi apparatus false UniProtKB:Q8N653 LZTR1 Hsap 68b0f0d000006733 CUL3/LZTR1/RBX1 complex ubiquitinates HRAS leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:68b0f0d000006733/68b0f0d000006775 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005794 Golgi apparatus false UniProtKB:P01112 HRAS Hsap 68b0f0d000006733 CUL3/LZTR1/RBX1 complex ubiquitinates HRAS leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:68b0f0d000006733/68b0f0d000006793 GO:0003924 GTPase activity GO:0007265 Ras protein signal transduction GO:0005794 Golgi apparatus false UniProtKB:P22033 MMUT Hsap 68b0f0d000007115 Malyl-CoA and Itaconyl-CoA inhibit the methylmalonyl-CoA mutase activity of MMUT (Human) NCBITaxon:9606 gomodel:68b0f0d000007115/68b0f0d000007116 GO:0004494 methylmalonyl-CoA mutase activity GO:1901290 succinyl-CoA biosynthetic process GO:0005739 mitochondrion true propionyl_coa_catabolism UniProtKB:Q96PE7 MCEE Hsap 68b0f0d000007115 Malyl-CoA and Itaconyl-CoA inhibit the methylmalonyl-CoA mutase activity of MMUT (Human) NCBITaxon:9606 gomodel:68b0f0d000007115/68b0f0d000007129 GO:0004493 methylmalonyl-CoA epimerase activity GO:1901290 succinyl-CoA biosynthetic process GO:0005739 mitochondrion true propionyl_coa_catabolism UniProtKB:P05165 PCCA Hsap 68b0f0d000007115 Malyl-CoA and Itaconyl-CoA inhibit the methylmalonyl-CoA mutase activity of MMUT (Human) NCBITaxon:9606 gomodel:68b0f0d000007115/68b0f0d000007137 GO:0004658 propionyl-CoA carboxylase activity GO:1901290 succinyl-CoA biosynthetic process GO:0005759 mitochondrial matrix true propionyl_coa_catabolism UniProtKB:A6NK06 ACOD1 Hsap 68b0f0d000007160 Detoxification of itaconate in macrophages (Human). NCBITaxon:9606 gomodel:68b0f0d000007160/68b0f0d000007214 GO:0047613 aconitate decarboxylase activity GO:0071222 cellular response to lipopolysaccharide GO:0005739 mitochondrion false UniProtKB:Q13825 AUH Hsap 68b0f0d000007160 Detoxification of itaconate in macrophages (Human). NCBITaxon:9606 gomodel:68b0f0d000007160/68b0f0d000007232 GO:0050011 itaconyl-CoA hydratase activity GO:0110052 toxic metabolite repair GO:0005739 mitochondrion false UniProtKB:Q8N0X4 CLYBL Hsap 68b0f0d000007160 Detoxification of itaconate in macrophages (Human). NCBITaxon:9606 gomodel:68b0f0d000007160/68b0f0d000007241 GO:0047777 (S)-citramalyl-CoA lyase activity GO:0110052 toxic metabolite repair GO:0005739 mitochondrion false GO:1902494 catalytic complex 68b0f0d000007160 Detoxification of itaconate in macrophages (Human). NCBITaxon:9606 gomodel:68b0f0d000007160/68b0f0d000007253 GO:0016878 acid-thiol ligase activity GO:0110052 toxic metabolite repair GO:0005739 mitochondrion false UniProtKB:Q8N0X4 CLYBL Hsap 68b0f0d000007269 Detoxification of malyl-CoA by CLYBL (Human). NCBITaxon:9606 gomodel:68b0f0d000007269/68b0f0d000007294 GO:0016289 acyl-CoA hydrolase activity GO:0110052 toxic metabolite repair GO:0005739 mitochondrion false GO:1902494 catalytic complex 68b0f0d000007269 Detoxification of malyl-CoA by CLYBL (Human). NCBITaxon:9606 gomodel:68b0f0d000007269/68b0f0d000007306 GO:0016878 acid-thiol ligase activity GO:0006108 malate metabolic process GO:0005739 mitochondrion false UniProtKB:Q02218 OGDH Hsap 68b0f0d000007269 Detoxification of malyl-CoA by CLYBL (Human). NCBITaxon:9606 gomodel:68b0f0d000007269/68b0f0d000007324 GO:0016831 carboxy-lyase activity GO:0006103 2-oxoglutarate metabolic process GO:0005739 mitochondrion false UniProtKB:P49675 STAR Hsap 68b0f0d000007688 Cholesterol transport between MOM & MIM by STAR adrenal gland (Human) NCBITaxon:9606 gomodel:68b0f0d000007688/68b0f0d000007689 GO:0120020 cholesterol transfer activity GO:0032367 intracellular cholesterol transport GO:0005741 mitochondrial outer membrane true adrenal_steroidogenesis UniProtKB:P63279 UBE2I Hsap 68b0f0d000008340 Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) NCBITaxon:9606 gomodel:68b0f0d000008340/68b0f0d000008417 GO:0061656 SUMO conjugating enzyme activity GO:0016925 protein sumoylation GO:0048471 perinuclear region of cytoplasm false UniProtKB:P34896 SHMT1 Hsap 68b0f0d000008340 Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) NCBITaxon:9606 gomodel:68b0f0d000008340/68b0f0d000008536 GO:0004372 glycine hydroxymethyltransferase activity GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process GO:0005657 replication fork false UniProtKB:P04818 TYMS Hsap 68b0f0d000008340 Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) NCBITaxon:9606 gomodel:68b0f0d000008340/68b0f0d000008553 GO:0004799 thymidylate synthase activity GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process GO:0005657 replication fork true thymidylate_synthesis UniProtKB:P00374 DHFR Hsap 68b0f0d000008340 Nuclear 'de novo' pyrimidine nucleobase biosynthetic process involving SHMT1, TYMS and DHFR (human) NCBITaxon:9606 gomodel:68b0f0d000008340/68b0f0d000008866 GO:0004146 dihydrofolate reductase activity GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process GO:0005657 replication fork false UniProtKB:Q5TA50 CPTP Hsap 68b0f0d000008443 C16-Ceramide-1-P transport enabled by CPTP (Human) NCBITaxon:9606 gomodel:68b0f0d000008443/68b0f0d000008456 GO:1902388 ceramide 1-phosphate transfer activity GO:1902389 ceramide 1-phosphate transport GO:0032588 trans-Golgi network membrane false UniProtKB:Q5TA50 CPTP Hsap 68b0f0d000008503 C18-Ceramide-1-P transport enabled by CPTP (Human) NCBITaxon:9606 gomodel:68b0f0d000008503/68b0f0d000008504 GO:1902388 ceramide 1-phosphate transfer activity GO:1902389 ceramide 1-phosphate transport GO:0032588 trans-Golgi network membrane false UniProtKB:Q5TA50 CPTP Hsap 68b0f0d000008519 C16-Ceramide-1-P transport enabled by CPTP (CERT1 transports Cer for C1P synthesis) (Human) NCBITaxon:9606 gomodel:68b0f0d000008519/68b0f0d000008520 GO:1902388 ceramide 1-phosphate transfer activity GO:1902389 ceramide 1-phosphate transport GO:0005829 cytosol false UniProtKB:Q8TCT0 CERK Hsap 68b0f0d000008519 C16-Ceramide-1-P transport enabled by CPTP (CERT1 transports Cer for C1P synthesis) (Human) NCBITaxon:9606 gomodel:68b0f0d000008519/68b0f0d000008562 GO:0001729 ceramide kinase activity GO:0006672 ceramide metabolic process GO:0160281 cytoplasmic side of trans-Golgi network membrane false UniProtKB:Q9Y5P4 CERT1 Hsap 68b0f0d000008519 C16-Ceramide-1-P transport enabled by CPTP (CERT1 transports Cer for C1P synthesis) (Human) NCBITaxon:9606 gomodel:68b0f0d000008519/68b0f0d000008570 GO:0120017 ceramide transfer activity GO:0006672 ceramide metabolic process GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:P52803 EFNA5 Hsap 68b0f0d000008614 EPHA5 and EFNA5 in glucose stimulated insulin secretion (Human) NCBITaxon:9606 gomodel:68b0f0d000008614/68b0f0d000008615 GO:0048018 receptor ligand activity GO:0048013 ephrin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P54756 EPHA5 Hsap 68b0f0d000008614 EPHA5 and EFNA5 in glucose stimulated insulin secretion (Human) NCBITaxon:9606 gomodel:68b0f0d000008614/68b0f0d000008626 GO:0005003 ephrin receptor activity GO:0048013 ephrin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63000 RAC1 Hsap 68b0f0d000008614 EPHA5 and EFNA5 in glucose stimulated insulin secretion (Human) NCBITaxon:9606 gomodel:68b0f0d000008614/68d5ebd600000033 GO:0003925 G protein activity GO:0007015 actin filament organization GO:0005938 cell cortex false UniProtKB:P17900 GM2A Hsap 68b0f0d000008690 Endolysosomal degradation SL: GM2A stimulates breakdown of GM2 by HEXA (Human) NCBITaxon:9606 gomodel:68b0f0d000008690/68b0f0d000008693 GO:7770043 lipid chaperone activity GO:0006689 ganglioside catabolic process GO:0160317 endolysosomal intralumenal vesicle membrane false UniProtKB:P06865 HEXA Hsap 68b0f0d000008690 Endolysosomal degradation SL: GM2A stimulates breakdown of GM2 by HEXA (Human) NCBITaxon:9606 gomodel:68b0f0d000008690/696022cd00002704 GO:0004563 beta-N-acetylhexosaminidase activity GO:0006689 ganglioside catabolic process GO:0036021 endolysosome lumen true keratan_chondroitin_sulfate_lysosomal_degradation UniProtKB:O15118 NPC1 Hsap 68b0f0d000009094 Cholesterol transport regulated by NPC1, NPC2 and GRAMD1B. (Human) NCBITaxon:9606 gomodel:68b0f0d000009094/68b0f0d000009095 GO:0120020 cholesterol transfer activity GO:0090120 lysosome to ER cholesterol transport GO:0098574 cytoplasmic side of lysosomal membrane false UniProtKB:P61916 NPC2 Hsap 68b0f0d000009094 Cholesterol transport regulated by NPC1, NPC2 and GRAMD1B. (Human) NCBITaxon:9606 gomodel:68b0f0d000009094/68b0f0d000009097 GO:0005319 lipid carrier activity GO:0090120 lysosome to ER cholesterol transport GO:0043202 lysosomal lumen false UniProtKB:Q3KR37 GRAMD1B Hsap 68b0f0d000009094 Cholesterol transport regulated by NPC1, NPC2 and GRAMD1B. (Human) NCBITaxon:9606 gomodel:68b0f0d000009094/68b0f0d000009177 GO:0120020 cholesterol transfer activity GO:0090120 lysosome to ER cholesterol transport GO:0005789 endoplasmic reticulum membrane false UniProtKB:P35610 SOAT1 Hsap 68b0f0d000009094 Cholesterol transport regulated by NPC1, NPC2 and GRAMD1B. (Human) NCBITaxon:9606 gomodel:68b0f0d000009094/6918f23700004652 GO:0034736 cholesterol O-acyltransferase activity GO:0008203 cholesterol metabolic process GO:0005789 endoplasmic reticulum membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000009694 Substance P binding to NK1 receptor triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009694/68b0f0d000009697 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P20366-PRO_0000033530 TAC1-Substance_P Hsap 68b0f0d000009694 Substance P binding to NK1 receptor triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009694/68b0f0d000009711 GO:0048018 receptor ligand activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P25103 TACR1 Hsap 68b0f0d000009694 Substance P binding to NK1 receptor triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009694/68b0f0d000009715 GO:0016496 substance P receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20366-PRO_0000033534 TAC1-NKA Hsap 68b0f0d000009768 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009768/68b0f0d000009769 GO:0048018 receptor ligand activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P21452 TACR2 Hsap 68b0f0d000009768 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009768/68b0f0d000009778 GO:0016497 substance K receptor activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68b0f0d000009768 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009768/68b0f0d000009786 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P20366-PRO_0000033534 TAC1-NKA Hsap 68b0f0d000009814 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009814/68b0f0d000009815 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P21452 TACR2 Hsap 68b0f0d000009814 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009814/68b0f0d000009820 GO:0016497 substance K receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68b0f0d000009814 Neurokinin A (substance K) binding to its receptor (TACR2/NK2R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68b0f0d000009814/68b0f0d000009824 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P29371 TACR3 Hsap 68d5ebd600000043 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000043/68d5ebd600000049 GO:0016498 neuromedin K receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68d5ebd600000043 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000043/68d5ebd600000053 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9UHF0 TAC3 Hsap 68d5ebd600000043 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers adenylate cyclase-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000043/68d5ebd600000071 GO:0048018 receptor ligand activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false GO:7770013 humanin receptor complex 68d5ebd600000274 Neuroprotection involving MT-RNR2 binding to a receptor complex containing IL27RA, CNTFR and IL6ST (human) NCBITaxon:9606 gomodel:68d5ebd600000274/68d5ebd600000275 GO:0038023 signaling receptor activity GO:0043524 negative regulation of neuron apoptotic process GO:0005886 plasma membrane false UniProtKB:Q8IVG9 MT-RNR2 Hsap 68d5ebd600000274 Neuroprotection involving MT-RNR2 binding to a receptor complex containing IL27RA, CNTFR and IL6ST (human) NCBITaxon:9606 gomodel:68d5ebd600000274/68d5ebd600000288 GO:0048018 receptor ligand activity GO:0043524 negative regulation of neuron apoptotic process GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 68d5ebd600000274 Neuroprotection involving MT-RNR2 binding to a receptor complex containing IL27RA, CNTFR and IL6ST (human) NCBITaxon:9606 gomodel:68d5ebd600000274/68d5ebd600000503 GO:0003700 DNA-binding transcription factor activity GO:0097696 cell surface receptor signaling pathway via STAT GO:0005634 nucleus false UniProtKB:P47871 GCGR Hsap 68d5ebd600000298 "GCGR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by glucagon (Human)" NCBITaxon:9606 gomodel:68d5ebd600000298/68d5ebd600000299 GO:0004967 glucagon receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P01275-PRO_0000011256 GCG-Glucagon Hsap 68d5ebd600000298 "GCGR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by glucagon (Human)" NCBITaxon:9606 gomodel:68d5ebd600000298/68d5ebd600000308 GO:0005179 hormone activity GO:0042593 glucose homeostasis GO:0005576 extracellular region false UniProtKB:P63092 GNAS Hsap 68d5ebd600000298 "GCGR-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by glucagon (Human)" NCBITaxon:9606 gomodel:68d5ebd600000298/68d5ebd600000318 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P47871 GCGR Hsap 68d5ebd600000330 GCGR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by glucagon (Human) NCBITaxon:9606 gomodel:68d5ebd600000330/68d5ebd600000331 GO:0004967 glucagon receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P01275-PRO_0000011256 GCG-Glucagon Hsap 68d5ebd600000330 GCGR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by glucagon (Human) NCBITaxon:9606 gomodel:68d5ebd600000330/68d5ebd600000338 GO:0005179 hormone activity GO:0042593 glucose homeostasis GO:0005576 extracellular region false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600000330 GCGR-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase following activation by glucagon (Human) NCBITaxon:9606 gomodel:68d5ebd600000330/68d5ebd600000362 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P29371 TACR3 Hsap 68d5ebd600000736 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000736/68d5ebd600000740 GO:0016498 neuromedin K receptor activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68d5ebd600000736 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000736/68d5ebd600000744 GO:0003925 G protein activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UHF0 TAC3 Hsap 68d5ebd600000736 Neuromedin K (Neurokinin B/NKB) binding to its receptor (TACR3/NK3R) triggers phospholipase C-activating G protein-coupled receptor signaling pathway (Human) NCBITaxon:9606 gomodel:68d5ebd600000736/68d5ebd600000755 GO:0048018 receptor ligand activity GO:0007209 phospholipase C-activating tachykinin receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P01350-PRO_0000010636 GAST-Gastrin Hsap 68d5ebd600001015 Gastrin-CCKBR pair leading to GNAQ activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001015/68d5ebd600001016 GO:0005179 hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32239 CCKBR Hsap 68d5ebd600001015 Gastrin-CCKBR pair leading to GNAQ activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001015/68d5ebd600001023 GO:0015054 gastrin receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68d5ebd600001015 Gastrin-CCKBR pair leading to GNAQ activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001015/68d5ebd600001030 GO:0003925 G protein activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P01350-PRO_0000010636 GAST-Gastrin Hsap 68d5ebd600001044 Gastrin-CCKBR pair leading to GNAI1 activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001044/68d5ebd600001045 GO:0005179 hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P32239 CCKBR Hsap 68d5ebd600001044 Gastrin-CCKBR pair leading to GNAI1 activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001044/68d5ebd600001052 GO:0015054 gastrin receptor activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600001044 Gastrin-CCKBR pair leading to GNAI1 activation (Human) NCBITaxon:9606 gomodel:68d5ebd600001044/68d5ebd600001091 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q15726-PRO_0000021548 KISS1-Kisspeptin-10 Hsap 68d5ebd600001111 KISS1/KISS1R signaling pathway induces membrane depolarization in GnRH neurons and stimulate GnRH release (Human) NCBITaxon:9606 gomodel:68d5ebd600001111/68d5ebd600001119 GO:0048018 receptor ligand activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q969F8 KISS1R Hsap 68d5ebd600001111 KISS1/KISS1R signaling pathway induces membrane depolarization in GnRH neurons and stimulate GnRH release (Human) NCBITaxon:9606 gomodel:68d5ebd600001111/68d5ebd600001139 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68d5ebd600001111 KISS1/KISS1R signaling pathway induces membrane depolarization in GnRH neurons and stimulate GnRH release (Human) NCBITaxon:9606 gomodel:68d5ebd600001111/68d5ebd600001151 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UBN4 TRPC4 Hsap 68d5ebd600001111 KISS1/KISS1R signaling pathway induces membrane depolarization in GnRH neurons and stimulate GnRH release (Human) NCBITaxon:9606 gomodel:68d5ebd600001111/68d5ebd600001483 GO:0005261 monoatomic cation channel activity GO:0051899 membrane depolarization GO:0005886 plasma membrane false UniProtKB:Q9HCC8 GDPD2 Hsap 68d5ebd600001161 GDPD2 in regulation of cell-matrix adhesion via uPAR (Human) NCBITaxon:9606 gomodel:68d5ebd600001161/68d5ebd600001164 GO:0140335 GPI anchor phospholipase C activity GO:0001953 negative regulation of cell-matrix adhesion GO:0005886 plasma membrane false UniProtKB:Q03405 PLAUR Hsap 68d5ebd600001161 GDPD2 in regulation of cell-matrix adhesion via uPAR (Human) NCBITaxon:9606 gomodel:68d5ebd600001161/68d5ebd600001171 GO:0098634 cell-matrix adhesion mediator activity GO:0007160 cell-matrix adhesion GO:0005886 plasma membrane false UniProtKB:P04004 VTN Hsap 68d5ebd600001161 GDPD2 in regulation of cell-matrix adhesion via uPAR (Human) NCBITaxon:9606 gomodel:68d5ebd600001161/68fac5ed00002540 GO:0098634 cell-matrix adhesion mediator activity GO:0007160 cell-matrix adhesion GO:0031012 extracellular matrix false UniProtKB:Q15726-PRO_0000021548 KISS1-Kisspeptin-10 Hsap 68d5ebd600001504 KISS1/KISS1R signaling pathway is involved in the negative regulation of bone resorption by osteoclasts (Human) NCBITaxon:9606 gomodel:68d5ebd600001504/68d5ebd600001505 GO:0048018 receptor ligand activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q969F8 KISS1R Hsap 68d5ebd600001504 KISS1/KISS1R signaling pathway is involved in the negative regulation of bone resorption by osteoclasts (Human) NCBITaxon:9606 gomodel:68d5ebd600001504/68d5ebd600001509 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q8NEJ0 DUSP18 Hsap 68d5ebd600001504 KISS1/KISS1R signaling pathway is involved in the negative regulation of bone resorption by osteoclasts (Human) NCBITaxon:9606 gomodel:68d5ebd600001504/68d5ebd600001588 GO:0004725 protein tyrosine phosphatase activity GO:0045671 negative regulation of osteoclast differentiation GO:0005737 cytoplasm false UniProtKB:P12931 SRC Hsap 68d5ebd600001504 KISS1/KISS1R signaling pathway is involved in the negative regulation of bone resorption by osteoclasts (Human) NCBITaxon:9606 gomodel:68d5ebd600001504/68d5ebd600001601 GO:0004672 protein kinase activity GO:0030316 osteoclast differentiation GO:0005737 cytoplasm false UniProtKB:P0C0P6 NPS Hsap 68d5ebd600002219 Neuropeptide S (NPS) and NPSR1 signaling via GNAQ/phospholipase C (Human) NCBITaxon:9606 gomodel:68d5ebd600002219/68d5ebd600002220 GO:0160041 neuropeptide activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q6W5P4-1 NPSR1 Hsap 68d5ebd600002219 Neuropeptide S (NPS) and NPSR1 signaling via GNAQ/phospholipase C (Human) NCBITaxon:9606 gomodel:68d5ebd600002219/68d5ebd600002226 GO:0008188 neuropeptide receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68d5ebd600002219 Neuropeptide S (NPS) and NPSR1 signaling via GNAQ/phospholipase C (Human) NCBITaxon:9606 gomodel:68d5ebd600002219/68d5ebd600002249 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false GO:0097058 CRLF-CLCF1 complex 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600002277 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P26992 CNTFR Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600002330 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0009897 external side of plasma membrane false UniProtKB:P23458 JAK1 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600002375 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600002384 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005829 cytosol false UniProtKB:P40763 STAT3 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600002393 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:Q92673 SORL1 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68d5ebd600003599 GO:0038024 cargo receptor activity GO:1905146 lysosomal protein catabolic process GO:0005886 plasma membrane false UniProtKB:O75462 CRLF1 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68fac5ed00002475 GO:0140597 protein carrier activity GO:0009306 protein secretion GO:0005576 extracellular region false UniProtKB:Q9UBD9 CLCF1 Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/68fac5ed00002493 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/6918f23700001913 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68d5ebd600002260 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68d5ebd600002260/6918f23700001926 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false GO:0097058 CRLF-CLCF1 complex 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/68d5ebd600002407 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P26992 CNTFR Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/68d5ebd600002414 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0009897 external side of plasma membrane false UniProtKB:Q06124 PTPN11 Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/68d5ebd600002594 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity GO:0019221 cytokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O75462 CRLF1 Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/68fac5ed00002518 GO:0140597 protein carrier activity GO:0009306 protein secretion GO:0005576 extracellular region false UniProtKB:Q9UBD9 CLCF1 Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/68fac5ed00002529 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/6918f23700001693 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68d5ebd600002406 CRLF-CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR complex via PTPN11 (human) NCBITaxon:9606 gomodel:68d5ebd600002406/6918f23700001707 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false GO:0097059 CNTFR-CLCF1 complex 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/68d5ebd600002653 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/68d5ebd600002700 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0019221 cytokine-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P26992 CNTFR Hsap 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/68d5ebd600002790 GO:0140597 protein carrier activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q9UBD9 CLCF1 Hsap 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/68d5ebd600003056 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/6918f23700002060 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68d5ebd600002652 sCNTFR-CLCF1 signaling pathway involving IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600002652/6918f23700002067 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68d5ebd600002906 UVA signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Melanin cap formation (Human) NCBITaxon:9606 gomodel:68d5ebd600002906/68d5ebd600002930 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9H1Y3 OPN3 Hsap 68d5ebd600002906 UVA signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Melanin cap formation (Human) NCBITaxon:9606 gomodel:68d5ebd600002906/68d5ebd600002951 GO:0008020 G protein-coupled photoreceptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600002906 UVA signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Melanin cap formation (Human) NCBITaxon:9606 gomodel:68d5ebd600002906/68d5ebd600002964 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68d5ebd600003015 Blue light signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Keratinocyte differenciation (Human) NCBITaxon:9606 gomodel:68d5ebd600003015/68d5ebd600003016 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9H1Y3 OPN3 Hsap 68d5ebd600003015 Blue light signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Keratinocyte differenciation (Human) NCBITaxon:9606 gomodel:68d5ebd600003015/68d5ebd600003025 GO:0008020 G protein-coupled photoreceptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600003015 Blue light signaling mediated by OPN3 photoreceptor via G-alpha-i (inhibitory)_Keratinocyte differenciation (Human) NCBITaxon:9606 gomodel:68d5ebd600003015/68d5ebd600003038 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/68d5ebd600003254 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P26992 CNTFR Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/68d5ebd600003276 GO:0140597 protein carrier activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:Q9HCC8 GDPD2 Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/68d5ebd600003285 GO:0004629 C-type glycerophospholipase activity GO:0051604 protein maturation GO:0005886 plasma membrane false UniProtKB:P26441 CNTF Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/68d5ebd600003348 GO:0005125 cytokine activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005576 extracellular region false GO:0032991 protein-containing complex 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/68fac5ed00000133 GO:0005125 cytokine activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/6918f23700002041 GO:0004896 cytokine receptor activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68d5ebd600003246 CNTF signaling pathway involving soluble CNTFR and the IL6ST-LIFR complex (human) NCBITaxon:9606 gomodel:68d5ebd600003246/6918f23700002048 GO:0004896 cytokine receptor activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6UWJ1 SLC9D1 Hsap 68d5ebd600003314 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction by SLC9D1. (Human) NCBITaxon:9606 gomodel:68d5ebd600003314/68d5ebd600003315 GO:0043495 protein-membrane adaptor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005886 plasma membrane false UniProtKB:P31749 AKT1 Hsap 68d5ebd600003314 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction by SLC9D1. (Human) NCBITaxon:9606 gomodel:68d5ebd600003314/68d5ebd600003324 GO:0004674 protein serine/threonine kinase activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005886 plasma membrane false UniProtKB:P05019 IGF1 Hsap 68d5ebd600003314 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction by SLC9D1. (Human) NCBITaxon:9606 gomodel:68d5ebd600003314/68d5ebd600003333 GO:0008083 growth factor activity GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0005576 extracellular region false UniProtKB:O43306 ADCY6 Hsap 68d5ebd600003358 UVA signaling mediated by OPN5 photoreceptor via G-alpha-i (inhibitory)_Circadian clock entrainment (Human) NCBITaxon:9606 gomodel:68d5ebd600003358/68d5ebd600003359 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q6U736 OPN5 Hsap 68d5ebd600003358 UVA signaling mediated by OPN5 photoreceptor via G-alpha-i (inhibitory)_Circadian clock entrainment (Human) NCBITaxon:9606 gomodel:68d5ebd600003358/68d5ebd600003368 GO:0008020 G protein-coupled photoreceptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600003358 UVA signaling mediated by OPN5 photoreceptor via G-alpha-i (inhibitory)_Circadian clock entrainment (Human) NCBITaxon:9606 gomodel:68d5ebd600003358/68d5ebd600003381 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01303 NPY Hsap 68d5ebd600003621 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 2 (NPY2R) (Human) NCBITaxon:9606 gomodel:68d5ebd600003621/68d5ebd600003634 GO:0160041 neuropeptide activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P49146 NPY2R Hsap 68d5ebd600003621 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 2 (NPY2R) (Human) NCBITaxon:9606 gomodel:68d5ebd600003621/68d5ebd600003644 GO:0008188 neuropeptide receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68d5ebd600003621 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 2 (NPY2R) (Human) NCBITaxon:9606 gomodel:68d5ebd600003621/68d5ebd600003654 GO:0010855 adenylate cyclase inhibitor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9UM07 PADI4 Hsap 68fac5ed00000028 Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). NCBITaxon:9606 gomodel:68fac5ed00000028/68fac5ed00000029 GO:0140794 histone arginine deiminase activity GO:0031452 negative regulation of heterochromatin formation GO:0005634 nucleus false UniProtKB:P05164 MPO Hsap 68fac5ed00000028 Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). NCBITaxon:9606 gomodel:68fac5ed00000028/68fac5ed00000042 GO:0140776 protein-containing complex destabilizing activity GO:0006337 nucleosome disassembly GO:0005634 nucleus false UniProtKB:P05164 MPO Hsap 68fac5ed00000028 Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). NCBITaxon:9606 gomodel:68fac5ed00000028/68fac5ed00000055 GO:0004601 peroxidase activity GO:0070943 neutrophil-mediated killing of symbiont cell GO:0140644 neutrophil extracellular trap false UniProtKB:P08246 ELANE Hsap 68fac5ed00000028 Formation of neutrophil extracellular traps (NETs) by PADI4 and MPO via dissociation of chromatin and microbicidal activity of NETs by ELANE and MPO (Human). NCBITaxon:9606 gomodel:68fac5ed00000028/68fac5ed00000074 GO:0004252 serine-type endopeptidase activity GO:0070943 neutrophil-mediated killing of symbiont cell GO:0140644 neutrophil extracellular trap false UniProtKB:P26992 CNTFR Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/68fac5ed00000174 GO:0004897 ciliary neurotrophic factor receptor activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0009897 external side of plasma membrane false UniProtKB:P23458 JAK1 Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/68fac5ed00000196 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/68fac5ed00000205 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P40763 STAT3 Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/68fac5ed00000214 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0005634 nucleus false UniProtKB:P26441 CNTF Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/68fac5ed00000250 GO:0005125 cytokine activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40189 IL6ST Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/6918f23700002009 GO:0015026 coreceptor activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68fac5ed00000166 CNTF signaling pathway involving CNTFR-IL6ST-LIFR complex via JAK-STAT (human) NCBITaxon:9606 gomodel:68fac5ed00000166/6918f23700002022 GO:0015026 coreceptor activity GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P01303 NPY Hsap 68fac5ed00000260 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 1 (NPY1R) are involved in regulation of eating behavior (Human) NCBITaxon:9606 gomodel:68fac5ed00000260/68fac5ed00000261 GO:0160041 neuropeptide activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P25929 NPY1R Hsap 68fac5ed00000260 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 1 (NPY1R) are involved in regulation of eating behavior (Human) NCBITaxon:9606 gomodel:68fac5ed00000260/68fac5ed00000270 GO:0008188 neuropeptide receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68fac5ed00000260 Neuropeptide Y (NPY) and Neuropeptide Y receptor type 1 (NPY1R) are involved in regulation of eating behavior (Human) NCBITaxon:9606 gomodel:68fac5ed00000260/68fac5ed00000280 GO:0010855 adenylate cyclase inhibitor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P48739 PITPNB Hsap 68fac5ed00000330 Phosphatidylinositol and phosphatidylcholine transfer enabled by PITPNB (Human) NCBITaxon:9606 gomodel:68fac5ed00000330/68fac5ed00002629 GO:0120014 phospholipid transfer activity GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0005829 cytosol false GO:0017059 serine palmitoyltransferase complex 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000573 GO:0004758 serine C-palmitoyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:Q06136 KDSR Hsap 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000596 GO:0047560 3-dehydrosphinganine reductase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q8N5B7 CERS5 Hsap 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000603 GO:0050291 sphingosine N-acyltransferase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane false UniProtKB:O15121 DEGS1 Hsap 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000614 GO:0042284 sphingolipid delta-4 desaturase activity GO:0046513 ceramide biosynthetic process GO:0098554 cytoplasmic side of endoplasmic reticulum membrane true sphingolipid_de_novo_synthesis UniProtKB:Q9Y5P4 CERT1 Hsap 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000625 GO:0120017 ceramide transfer activity GO:0006686 sphingomyelin biosynthetic process GO:0160258 endoplasmic reticulum-trans-Golgi network membrane contact site false UniProtKB:Q86VZ5 SGMS1 Hsap 68fac5ed00000572 De novo sphingomyelin synthesis via CERS5. (Human) NCBITaxon:9606 gomodel:68fac5ed00000572/68fac5ed00000637 GO:0033188 sphingomyelin synthase activity GO:0006686 sphingomyelin biosynthetic process GO:1990676 Golgi trans cisterna membrane false UniProtKB:Q9HCC8 GDPD2 Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/68fac5ed00001528 GO:0140335 GPI anchor phospholipase C activity GO:0010716 negative regulation of extracellular matrix disassembly GO:0005886 plasma membrane false UniProtKB:Q03405 PLAUR Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/68fac5ed00001533 GO:0008047 enzyme activator activity GO:0090091 positive regulation of extracellular matrix disassembly GO:0005886 plasma membrane false UniProtKB:P00749 PLAU Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/68fac5ed00001540 GO:0004252 serine-type endopeptidase activity GO:0090091 positive regulation of extracellular matrix disassembly GO:0009986 cell surface false UniProtKB:P00747 PLG Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/68fac5ed00001547 GO:0004252 serine-type endopeptidase activity GO:0022617 extracellular matrix disassembly GO:0005576 extracellular region false UniProtKB:P08253 MMP2 Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/6918f23700000747 GO:0004222 metalloendopeptidase activity GO:0030574 collagen catabolic process GO:0031012 extracellular matrix false UniProtKB:P14780 MMP9 Hsap 68fac5ed00001527 Plasminogen/plasmin function in extracellular matrix disassembly (Human) NCBITaxon:9606 gomodel:68fac5ed00001527/6918f23700000758 GO:0004222 metalloendopeptidase activity GO:0030574 collagen catabolic process GO:0031012 extracellular matrix false UniProtKB:O43463 SUV39H1 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001852 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031508 pericentric heterochromatin formation GO:0005721 pericentric heterochromatin false UniProtKB:P45973 CBX5 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001869 GO:0062072 histone H3K9me2/3 reader activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:Q7L622 G2E3 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001878 GO:0140851 histone H3K14 ubiquitin ligase activity GO:0031507 heterochromatin formation GO:0005721 pericentric heterochromatin false UniProtKB:Q9H5I1 SUV39H2 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001888 GO:0140949 histone H3K9 trimethyltransferase activity GO:0031508 pericentric heterochromatin formation GO:0005721 pericentric heterochromatin false UniProtKB:P83916 CBX1 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001896 GO:0062072 histone H3K9me2/3 reader activity GO:0031507 heterochromatin formation GO:0000792 heterochromatin false UniProtKB:O43463 SUV39H1 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001935 GO:0140258 histone H3K14ub reader activity GO:0031507 heterochromatin formation GO:0005721 pericentric heterochromatin false UniProtKB:Q9H5I1 SUV39H2 Hsap 68fac5ed00001851 G2E3 promotes heterochromatin formation by catalyzing ubiquitination of histone H3, leading to recruitment of SUV39H1 and/SUV39H2 (Human). NCBITaxon:9606 gomodel:68fac5ed00001851/68fac5ed00001944 GO:0062072 histone H3K9me2/3 reader activity GO:0031507 heterochromatin formation GO:0005721 pericentric heterochromatin false UniProtKB:O43306 ADCY6 Hsap 68fac5ed00001966 Light signaling mediated by OPN4 photoreceptor via G-alpha-i (inhibitory) (Human) NCBITaxon:9606 gomodel:68fac5ed00001966/68fac5ed00001967 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9UHM6 OPN4 Hsap 68fac5ed00001966 Light signaling mediated by OPN4 photoreceptor via G-alpha-i (inhibitory) (Human) NCBITaxon:9606 gomodel:68fac5ed00001966/68fac5ed00001976 GO:0008020 G protein-coupled photoreceptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63096 GNAI1 Hsap 68fac5ed00001966 Light signaling mediated by OPN4 photoreceptor via G-alpha-i (inhibitory) (Human) NCBITaxon:9606 gomodel:68fac5ed00001966/68fac5ed00001989 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9UHM6 OPN4 Hsap 68fac5ed00002046 Light signaling mediated by OPN4 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:68fac5ed00002046/68fac5ed00002052 GO:0008020 G protein-coupled photoreceptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 68fac5ed00002046 Light signaling mediated by OPN4 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:68fac5ed00002046/68fac5ed00002060 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 68fac5ed00002046 Light signaling mediated by OPN4 receptor via G-alpha-s (activatory) (Human) NCBITaxon:9606 gomodel:68fac5ed00002046/68fac5ed00002068 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q9UHM6 OPN4 Hsap 68fac5ed00002108 Light signaling mediated by OPN4 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:68fac5ed00002108/68fac5ed00002109 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 68fac5ed00002108 Light signaling mediated by OPN4 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:68fac5ed00002108/68fac5ed00002118 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 68fac5ed00002108 Light signaling mediated by OPN4 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG) (Human). NCBITaxon:9606 gomodel:68fac5ed00002108/68fac5ed00002125 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:O00562 PITPNM1 Hsap 68fac5ed00002250 Phosphatidylinositol and phosphatidic acid transport by PITPNM1 in ER-PM MCS (response to PLC) (Human) NCBITaxon:9606 gomodel:68fac5ed00002250/68fac5ed00002251 GO:0120014 phospholipid transfer activity GO:1902633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:O95292 VAPB Hsap 68fac5ed00002250 Phosphatidylinositol and phosphatidic acid transport by PITPNM1 in ER-PM MCS (response to PLC) (Human) NCBITaxon:9606 gomodel:68fac5ed00002250/693b3c0900002622 GO:0160214 endoplasmic reticulum-plasma membrane adaptor activity GO:1902633 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q96CX6 LRRC58 Hsap 68fac5ed00002309 LRRC58 is a negative regulator of taurine biosynthesis by mediating by mediating ubiquitination and degradation of CDO1 (Human). NCBITaxon:9606 gomodel:68fac5ed00002309/68fac5ed00002310 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q93034 CUL5 Hsap 68fac5ed00002309 LRRC58 is a negative regulator of taurine biosynthesis by mediating by mediating ubiquitination and degradation of CDO1 (Human). NCBITaxon:9606 gomodel:68fac5ed00002309/68fac5ed00002321 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9UBF6 RNF7 Hsap 68fac5ed00002309 LRRC58 is a negative regulator of taurine biosynthesis by mediating by mediating ubiquitination and degradation of CDO1 (Human). NCBITaxon:9606 gomodel:68fac5ed00002309/68fac5ed00002328 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q16878 CDO1 Hsap 68fac5ed00002309 LRRC58 is a negative regulator of taurine biosynthesis by mediating by mediating ubiquitination and degradation of CDO1 (Human). NCBITaxon:9606 gomodel:68fac5ed00002309/68fac5ed00002359 GO:0017172 cysteine dioxygenase activity GO:0019448 L-cysteine catabolic process false UniProtKB:Q00169 PITPNA Hsap 68fac5ed00002608 Phosphatidylinositol intermembrane transport enabled by PITPNA (Human) NCBITaxon:9606 gomodel:68fac5ed00002608/68fac5ed00002609 GO:0008526 phosphatidylinositol transfer activity GO:0015914 phospholipid transport GO:0005829 cytosol false UniProtKB:Q9UBF8 PI4KB Hsap 68fac5ed00002608 Phosphatidylinositol intermembrane transport enabled by PITPNA (Human) NCBITaxon:9606 gomodel:68fac5ed00002608/68fac5ed00002642 GO:0004430 1-phosphatidylinositol 4-kinase activity GO:0046854 phosphatidylinositol phosphate biosynthetic process GO:0160281 cytoplasmic side of trans-Golgi network membrane false UniProtKB:P26992 CNTFR Hsap 68fac5ed00002909 CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) NCBITaxon:9606 gomodel:68fac5ed00002909/68fac5ed00002910 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0009897 external side of plasma membrane false UniProtKB:Q9UBD9 CLCF1 Hsap 68fac5ed00002909 CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) NCBITaxon:9606 gomodel:68fac5ed00002909/68fac5ed00002970 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 68fac5ed00002909 CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) NCBITaxon:9606 gomodel:68fac5ed00002909/68fac5ed00002980 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0019221 cytokine-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P40189 IL6ST Hsap 68fac5ed00002909 CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) NCBITaxon:9606 gomodel:68fac5ed00002909/6918f23700001609 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 68fac5ed00002909 CLCF1 signaling pathway involving CNTFR-IL6ST-LIFR (human) NCBITaxon:9606 gomodel:68fac5ed00002909/6918f23700001617 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P04201 MAS1 Hsap 68fac5ed00003102 CXCL17 activation of MAS receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003102/68fac5ed00003109 GO:0004930 G protein-coupled receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6UXB2 CXCL17 Hsap 68fac5ed00003102 CXCL17 activation of MAS receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003102/68fac5ed00003116 GO:0008009 chemokine activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P32121 ARRB2 Hsap 68fac5ed00003102 CXCL17 activation of MAS receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003102/68fac5ed00003126 GO:0030674 protein-macromolecule adaptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q96LB1 MRGPRX2 Hsap 68fac5ed00003136 CXCL17 activation of MRGPRX2 receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003136/68fac5ed00003137 GO:0004930 G protein-coupled receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6UXB2 CXCL17 Hsap 68fac5ed00003136 CXCL17 activation of MRGPRX2 receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003136/68fac5ed00003144 GO:0008009 chemokine activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P32121 ARRB2 Hsap 68fac5ed00003136 CXCL17 activation of MRGPRX2 receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003136/68fac5ed00003154 GO:0030674 protein-macromolecule adaptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q96LB2 MRGPRX1 Hsap 68fac5ed00003166 CXCL17 activation of MRGPRX1receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003166/68fac5ed00003167 GO:0004930 G protein-coupled receptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6UXB2 CXCL17 Hsap 68fac5ed00003166 CXCL17 activation of MRGPRX1receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003166/68fac5ed00003174 GO:0008009 chemokine activity GO:0070098 chemokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P32121 ARRB2 Hsap 68fac5ed00003166 CXCL17 activation of MRGPRX1receptor leading to chemotaxis (Human) NCBITaxon:9606 gomodel:68fac5ed00003166/68fac5ed00003184 GO:0030674 protein-macromolecule adaptor activity GO:0070098 chemokine-mediated signaling pathway GO:0005737 cytoplasm false UniProtKB:O75038 PLCH2 Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/68fac5ed00003197 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0046488 phosphatidylinositol metabolic process GO:0005886 plasma membrane false UniProtKB:Q86XP1 DGKH Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/68fac5ed00003204 GO:0004143 ATP-dependent diacylglycerol kinase activity GO:0046339 diacylglycerol metabolic process GO:0005886 plasma membrane false UniProtKB:O00562 PITPNM1 Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/68fac5ed00003213 GO:0008526 phosphatidylinositol transfer activity GO:1902648 positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:Q9BZ72 PITPNM2 Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/68fac5ed00003550 GO:0008526 phosphatidylinositol transfer activity GO:1902648 positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:0140268 endoplasmic reticulum-plasma membrane contact site false UniProtKB:P42356 PI4KA Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/693b3c0900000657 GO:0004430 1-phosphatidylinositol 4-kinase activity GO:0046854 phosphatidylinositol phosphate biosynthetic process GO:0005886 plasma membrane false UniProtKB:Q99755 PIP5K1A Hsap 68fac5ed00003196 Regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process. (Human) NCBITaxon:9606 gomodel:68fac5ed00003196/693b3c0900000897 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0046854 phosphatidylinositol phosphate biosynthetic process GO:0005886 plasma membrane false UniProtKB:Q13315 ATM Hsap 68fac5ed00003259 Role of TRIM28 palmitoylation in DNA damage response (Human) NCBITaxon:9606 gomodel:68fac5ed00003259/68fac5ed00003260 GO:0004674 protein serine/threonine kinase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q5W0Z9 ZDHHC20 Hsap 68fac5ed00003259 Role of TRIM28 palmitoylation in DNA damage response (Human) NCBITaxon:9606 gomodel:68fac5ed00003259/68fac5ed00003267 GO:0016409 palmitoyltransferase activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q13263 TRIM28 Hsap 68fac5ed00003259 Role of TRIM28 palmitoylation in DNA damage response (Human) NCBITaxon:9606 gomodel:68fac5ed00003259/68fac5ed00003274 GO:0140463 chromatin-protein adaptor activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:P38398 BRCA1 Hsap 68fac5ed00003259 Role of TRIM28 palmitoylation in DNA damage response (Human) NCBITaxon:9606 gomodel:68fac5ed00003259/68fac5ed00003283 GO:0003713 transcription coactivator activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q12888 TP53BP1 Hsap 68fac5ed00003259 Role of TRIM28 palmitoylation in DNA damage response (Human) NCBITaxon:9606 gomodel:68fac5ed00003259/68fac5ed00003297 GO:0061649 ubiquitin-modified histone reader activity GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:P42574 CASP3 Hsap 68fac5ed00003307 XKR9 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003307/68fac5ed00003308 GO:0004197 cysteine-type endopeptidase activity GO:0016485 protein processing false UniProtKB:Q5GH70-PRO_0000453293 XKR9-XK-related_protein_9_processed_form Hsap 68fac5ed00003307 XKR9 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003307/68fac5ed00003317 GO:0017128 phospholipid scramblase activity GO:0070782 phosphatidylserine exposure on apoptotic cell surface GO:0005886 plasma membrane false UniProtKB:Q96H15 TIMD4 Hsap 68fac5ed00003307 XKR9 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003307/68fac5ed00003336 GO:0001786 phosphatidylserine binding GO:0043277 apoptotic cell clearance GO:0005886 plasma membrane false UniProtKB:Q9Y4K3 TRAF6 Hsap 68fac5ed00003348 TRIM28 negative regulation of of NF-kappa-B signaling via TRAF6 SUMOylation (Human) NCBITaxon:9606 gomodel:68fac5ed00003348/68fac5ed00003365 GO:0061630 ubiquitin protein ligase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:O43318 MAP3K7 Hsap 68fac5ed00003348 TRIM28 negative regulation of of NF-kappa-B signaling via TRAF6 SUMOylation (Human) NCBITaxon:9606 gomodel:68fac5ed00003348/68fac5ed00003369 GO:0004674 protein serine/threonine kinase activity GO:0007249 canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q13263 TRIM28 Hsap 68fac5ed00003348 TRIM28 negative regulation of of NF-kappa-B signaling via TRAF6 SUMOylation (Human) NCBITaxon:9606 gomodel:68fac5ed00003348/68fac5ed00003397 GO:0061665 SUMO ligase activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005634 nucleus false UniProtKB:P42574 CASP3 Hsap 68fac5ed00003409 XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003409/68fac5ed00003410 GO:0004197 cysteine-type endopeptidase activity GO:0016485 protein processing false UniProtKB:Q5GH76-PRO_0000453289 XKR4-XK-related_protein_4_processed_form Hsap 68fac5ed00003409 XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003409/68fac5ed00003419 GO:0017128 phospholipid scramblase activity GO:0070782 phosphatidylserine exposure on apoptotic cell surface GO:0005886 plasma membrane false UniProtKB:Q96H15 TIMD4 Hsap 68fac5ed00003409 XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003409/68fac5ed00003436 GO:0001786 phosphatidylserine binding GO:0043277 apoptotic cell clearance GO:0005886 plasma membrane false UniProtKB:P42574 CASP3 Hsap 68fac5ed00003409 XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003409/68fac5ed00003446 GO:0004197 cysteine-type endopeptidase activity GO:0016485 protein processing false UniProtKB:Q13426-PRO_0000453296 XRCC4-XRCC4/C Hsap 68fac5ed00003409 XKR4 promotes phosphatidylserine exposure on apoptotic cell surface following activation by a cleavage product of XRCC4 and CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003409/68fac5ed00003455 GO:0008047 enzyme activator activity GO:1905782 positive regulation of phosphatidylserine exposure on apoptotic cell surface GO:0005737 cytoplasm false UniProtKB:P42574 CASP3 Hsap 68fac5ed00003572 XKR8 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003572/68fac5ed00003573 GO:0004197 cysteine-type endopeptidase activity GO:0016485 protein processing false UniProtKB:Q9H6D3-PRO_0000423984 XKR8-XK-related_protein_8_processed_form Hsap 68fac5ed00003572 XKR8 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003572/68fac5ed00003582 GO:0017128 phospholipid scramblase activity GO:0070782 phosphatidylserine exposure on apoptotic cell surface GO:0005886 plasma membrane false UniProtKB:Q96H15 TIMD4 Hsap 68fac5ed00003572 XKR8 promotes phosphatidylserine exposure on apoptotic cell surface following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003572/68fac5ed00003599 GO:0001786 phosphatidylserine binding GO:0043277 apoptotic cell clearance GO:0005886 plasma membrane false UniProtKB:P42574 CASP3 Hsap 68fac5ed00003609 XKR8 promotes synapse pruning by mediating phosphatidylserine exposure following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003609/68fac5ed00003610 GO:0004197 cysteine-type endopeptidase activity GO:0016485 protein processing false UniProtKB:Q9H6D3-PRO_0000423984 XKR8-XK-related_protein_8_processed_form Hsap 68fac5ed00003609 XKR8 promotes synapse pruning by mediating phosphatidylserine exposure following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003609/68fac5ed00003619 GO:0017128 phospholipid scramblase activity GO:0098883 synapse pruning GO:0005886 plasma membrane false UniProtKB:Q9Y653-5 ADGRG1 Hsap 68fac5ed00003609 XKR8 promotes synapse pruning by mediating phosphatidylserine exposure following activation by CASP3 (Human). NCBITaxon:9606 gomodel:68fac5ed00003609/68fac5ed00003636 GO:0001786 phosphatidylserine binding GO:0098883 synapse pruning GO:0005886 plasma membrane false UniProtKB:P0DN78 OPN1MW3 Hsap 68fac5ed00003700 Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003700/68fac5ed00003710 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P19087 GNAT2 Hsap 68fac5ed00003700 Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003700/68fac5ed00003718 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:Q13956 PDE6H Hsap 68fac5ed00003700 Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003700/69ea894900003514 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P51160 PDE6C Hsap 68fac5ed00003700 Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003700/69ea894900003526 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0120201 cone photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 68fac5ed00003700 Green light signaling mediated by OPN1MW3 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003700/69ea894900003537 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0120201 cone photoreceptor disc membrane false UniProtKB:P04000 OPN1LW Hsap 68fac5ed00003872 Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003872/68fac5ed00003882 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P19087 GNAT2 Hsap 68fac5ed00003872 Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003872/68fac5ed00003890 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:Q13956 PDE6H Hsap 68fac5ed00003872 Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003872/69ea894900000222 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P51160 PDE6C Hsap 68fac5ed00003872 Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003872/69ea894900000234 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 68fac5ed00003872 Red light signaling mediated by OPN1LW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:68fac5ed00003872/69ea894900003340 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0120201 cone photoreceptor disc membrane false UniProtKB:P29466 CASP1 Hsap 68fac5ed00004201 GSGMD activation by TRAF1/TRAF2 ubiquitin complex (Human) NCBITaxon:9606 gomodel:68fac5ed00004201/68fac5ed00004202 GO:0004197 cysteine-type endopeptidase activity GO:0051604 protein maturation GO:0005829 cytosol false UniProtKB:P57764-PRO_0000459018 GSDMD-Gasdermin-D_p40 Hsap 68fac5ed00004201 GSGMD activation by TRAF1/TRAF2 ubiquitin complex (Human) NCBITaxon:9606 gomodel:68fac5ed00004201/68fac5ed00004229 GO:0022829 wide pore channel activity GO:0050729 positive regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:Q13077 TRAF1 Hsap 68fac5ed00004201 GSGMD activation by TRAF1/TRAF2 ubiquitin complex (Human) NCBITaxon:9606 gomodel:68fac5ed00004201/68fac5ed00004263 GO:0030674 protein-macromolecule adaptor activity GO:0140639 positive regulation of pyroptotic inflammatory response GO:0005829 cytosol false UniProtKB:Q12933 TRAF2 Hsap 68fac5ed00004201 GSGMD activation by TRAF1/TRAF2 ubiquitin complex (Human) NCBITaxon:9606 gomodel:68fac5ed00004201/68fac5ed00004275 GO:0061630 ubiquitin protein ligase activity GO:0140639 positive regulation of pyroptotic inflammatory response GO:0005829 cytosol false UniProtKB:Q8N413 SLC25A45 Hsap 69169b7400000023 SLC25A45 mediates mitochondrial uptake of methylated lysine for carnitine biosynthesis (Human). NCBITaxon:9606 gomodel:69169b7400000023/69169b7400000066 GO:7770026 N(6),N(6),N(6)-trimethyl-L-lysine transmembrane transporter activity GO:0045329 carnitine biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q9NVH6 TMLHE Hsap 69169b7400000023 SLC25A45 mediates mitochondrial uptake of methylated lysine for carnitine biosynthesis (Human). NCBITaxon:9606 gomodel:69169b7400000023/69169b7400000073 GO:0050353 trimethyllysine dioxygenase activity GO:0045329 carnitine biosynthetic process GO:0005759 mitochondrial matrix false UniProtKB:O75936 BBOX1 Hsap 69169b7400000023 SLC25A45 mediates mitochondrial uptake of methylated lysine for carnitine biosynthesis (Human). NCBITaxon:9606 gomodel:69169b7400000023/69169b7400000100 GO:0008336 gamma-butyrobetaine dioxygenase activity GO:0045329 carnitine biosynthetic process false UniProtKB:Q96QS3 ARX Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000150 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:7770021 intestinal type G enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:Q2TB10 ZNF800 Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000157 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:7770019 negative regulation of enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:O43316 PAX4 Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000164 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:7770020 intestinal enterochromaffin enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:O43316 PAX4 Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000174 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:7770019 negative regulation of enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:Q96QS3 ARX Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000184 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:7770022 intestinal type I enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:Q96QS3 ARX Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000191 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:7770023 intestinal type L enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:Q96QS3 ARX Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000198 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:7770024 intestinal type N enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:Q96QS3 ARX Hsap 69169b7400000113 ZNF800 acts as a master repressor of enteroendocrine differentiation (Human). NCBITaxon:9606 gomodel:69169b7400000113/69169b7400000205 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:7770025 intestinal type D enteroendocrine cell differentiation GO:0000785 chromatin false UniProtKB:P18545 PDE6G Hsap 6918f23700000035 Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:6918f23700000035/6918f23700000036 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120202 rod photoreceptor disc membrane false UniProtKB:P08100 RHO Hsap 6918f23700000035 Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:6918f23700000035/6918f23700000045 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120202 rod photoreceptor disc membrane false UniProtKB:P11488 GNAT1 Hsap 6918f23700000035 Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:6918f23700000035/6918f23700000053 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120202 rod photoreceptor disc membrane false GO:7770030 rod photoreceptor phosphodiesterase 6 complex 6918f23700000035 Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:6918f23700000035/6918f23700001883 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120202 rod photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 6918f23700000035 Dim light signaling mediated by RHO photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:6918f23700000035/69ea894900004226 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0042622 photoreceptor outer segment membrane false UniProtKB:Q8WZ19 KCTD13 Hsap 6918f23700000069 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing KCDT13 (Human) NCBITaxon:9606 gomodel:6918f23700000069/6918f23700000070 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13618 CUL3 Hsap 6918f23700000069 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing KCDT13 (Human) NCBITaxon:9606 gomodel:6918f23700000069/6918f23700000097 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6918f23700000069 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing KCDT13 (Human) NCBITaxon:9606 gomodel:6918f23700000069/6918f23700000107 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P61586 RHOA Hsap 6918f23700000069 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing KCDT13 (Human) NCBITaxon:9606 gomodel:6918f23700000069/6918f23700000159 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:Q13829 TNFAIP1 Hsap 6918f23700000167 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing TNFAIP1 (Human) NCBITaxon:9606 gomodel:6918f23700000167/6918f23700000168 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q13618 CUL3 Hsap 6918f23700000167 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing TNFAIP1 (Human) NCBITaxon:9606 gomodel:6918f23700000167/6918f23700000175 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 6918f23700000167 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing TNFAIP1 (Human) NCBITaxon:9606 gomodel:6918f23700000167/6918f23700000183 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:P61586 RHOA Hsap 6918f23700000167 Ubiquitination and degradation of RHOA by a CUL3-RING complex containing TNFAIP1 (Human) NCBITaxon:9606 gomodel:6918f23700000167/6918f23700000197 GO:0003925 G protein activity GO:0007266 Rho protein signal transduction GO:0005829 cytosol false UniProtKB:Q9NR96 TLR9 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700000329 GO:0038187 pattern recognition receptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0031901 early endosome membrane false UniProtKB:Q99836 MYD88 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700000408 GO:0035591 signaling adaptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9NWZ3 IRAK4 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700001946 GO:0004674 protein serine/threonine kinase activity GO:0034162 toll-like receptor 9 signaling pathway GO:0005737 cytoplasm false UniProtKB:P51617 IRAK1 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700001956 GO:0035591 signaling adaptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9Y4K3 TRAF6 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700001964 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q13568 IRF5 Hsap 6918f23700000328 TLR9 signaling pathway leading to IRF5 activation (Human) NCBITaxon:9606 gomodel:6918f23700000328/6918f23700001984 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0034162 toll-like receptor 9 signaling pathway GO:0005634 nucleus false UniProtKB:P32245 MC4R Hsap 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000535 GO:0004978 corticotropin receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000543 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000551 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9Y5Y3 GPR45 Hsap 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000578 GO:0140597 protein carrier activity GO:0097499 protein localization to non-motile cilium GO:0005886 plasma membrane false UniProtKB:O75386 TULP3 Hsap 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000587 GO:0030674 protein-macromolecule adaptor activity GO:0097499 protein localization to non-motile cilium GO:0005886 plasma membrane false GO:0030991 intraciliary transport particle A 6918f23700000529 GPR45 acts as a regulator of food intake in the paraventricular nucleus of the hypothalamus by mediating transport of GNAS/G(s) into primary cilia (Human) NCBITaxon:9606 gomodel:6918f23700000529/6918f23700000605 GO:0140597 protein carrier activity GO:0097499 protein localization to non-motile cilium false UniProtKB:Q9BZ72 PITPNM2 Hsap 6918f23700000622 PA sensor activity and PI transport between ER and PM enabled by PITPNM2. (Human) NCBITaxon:9606 gomodel:6918f23700000622/6918f23700000623 GO:0005319 lipid carrier activity GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P21757 MSR1 Hsap 6918f23700001532 TLR9 activation by EGFR and SYK (Human) NCBITaxon:9606 gomodel:6918f23700001532/6918f23700001631 GO:0038187 pattern recognition receptor activity GO:0034165 positive regulation of toll-like receptor 9 signaling pathway GO:0005886 plasma membrane false UniProtKB:P07948 LYN Hsap 6918f23700001532 TLR9 activation by EGFR and SYK (Human) NCBITaxon:9606 gomodel:6918f23700001532/6918f23700001638 GO:0004713 protein tyrosine kinase activity GO:0034165 positive regulation of toll-like receptor 9 signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P43405 SYK Hsap 6918f23700001532 TLR9 activation by EGFR and SYK (Human) NCBITaxon:9606 gomodel:6918f23700001532/6918f23700001647 GO:0004713 protein tyrosine kinase activity GO:0034165 positive regulation of toll-like receptor 9 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q9NR96 TLR9 Hsap 6918f23700001532 TLR9 activation by EGFR and SYK (Human) NCBITaxon:9606 gomodel:6918f23700001532/6918f23700001657 GO:0038187 pattern recognition receptor activity GO:0034162 toll-like receptor 9 signaling pathway GO:0031901 early endosome membrane false UniProtKB:P00533 EGFR Hsap 6918f23700001532 TLR9 activation by EGFR and SYK (Human) NCBITaxon:9606 gomodel:6918f23700001532/6918f23700001668 GO:0004713 protein tyrosine kinase activity GO:0034165 positive regulation of toll-like receptor 9 signaling pathway GO:0031901 early endosome membrane false UniProtKB:P15018 LIF Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003279 GO:0005125 cytokine activity GO:0048861 leukemia inhibitory factor signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003289 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0048861 leukemia inhibitory factor signaling pathway GO:0005634 nucleus false UniProtKB:P40189 IL6ST Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003296 GO:0015026 coreceptor activity GO:0048861 leukemia inhibitory factor signaling pathway GO:0005886 plasma membrane false UniProtKB:P42702 LIFR Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003303 GO:0004923 leukemia inhibitory factor receptor activity GO:0048861 leukemia inhibitory factor signaling pathway GO:0005886 plasma membrane false UniProtKB:P23458 JAK1 Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003500 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 6918f23700003265 LIF signaling pathway involving IL6ST-LIFR (human) NCBITaxon:9606 gomodel:6918f23700003265/6918f23700003735 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9NYK1 TLR7 Hsap 6918f23700004278 Activation of TLR7 by PLD3 (Human) NCBITaxon:9606 gomodel:6918f23700004278/6918f23700004279 GO:0038187 pattern recognition receptor activity GO:0034154 toll-like receptor 7 signaling pathway GO:0005765 lysosomal membrane false UniProtKB:Q8IV08 PLD3 Hsap 6918f23700004278 Activation of TLR7 by PLD3 (Human) NCBITaxon:9606 gomodel:6918f23700004278/6918f23700004284 GO:0004534 5'-3' RNA exonuclease activity GO:0045087 innate immune response GO:0043202 lysosomal lumen false UniProtKB:O00584 RNASET2 Hsap 6918f23700004278 Activation of TLR7 by PLD3 (Human) NCBITaxon:9606 gomodel:6918f23700004278/6918f23700004287 GO:0033897 ribonuclease T2 activity GO:0045087 innate immune response GO:0043202 lysosomal lumen false UniProtKB:Q8IV08 PLD3 Hsap 6918f23700004278 Activation of TLR7 by PLD3 (Human) NCBITaxon:9606 gomodel:6918f23700004278/6918f23700004303 GO:0004534 5'-3' RNA exonuclease activity GO:0045087 innate immune response GO:0043202 lysosomal lumen false UniProtKB:Q9NYK1 TLR7 Hsap 6918f23700004582 Activation of TLR7 by PLD4 (Human) NCBITaxon:9606 gomodel:6918f23700004582/6918f23700004583 GO:0038187 pattern recognition receptor activity GO:0034154 toll-like receptor 7 signaling pathway GO:0005765 lysosomal membrane false UniProtKB:Q96BZ4 PLD4 Hsap 6918f23700004582 Activation of TLR7 by PLD4 (Human) NCBITaxon:9606 gomodel:6918f23700004582/6918f23700004588 GO:0004534 5'-3' RNA exonuclease activity GO:0045087 innate immune response GO:0005764 lysosome false UniProtKB:O00584 RNASET2 Hsap 6918f23700004582 Activation of TLR7 by PLD4 (Human) NCBITaxon:9606 gomodel:6918f23700004582/6918f23700004591 GO:0033897 ribonuclease T2 activity GO:0045087 innate immune response GO:0043202 lysosomal lumen false UniProtKB:Q96BZ4 PLD4 Hsap 6918f23700004582 Activation of TLR7 by PLD4 (Human) NCBITaxon:9606 gomodel:6918f23700004582/6918f23700004606 GO:0004534 5'-3' RNA exonuclease activity GO:0045087 innate immune response GO:0005764 lysosome false UniProtKB:Q13501 SQSTM1 Hsap 693b3c0900000008 TRIM25 inhibition of SQSTM1 (Human). NCBITaxon:9606 gomodel:693b3c0900000008/693b3c0900000009 GO:0030674 protein-macromolecule adaptor activity GO:0006914 autophagy GO:0005776 autophagosome false UniProtKB:Q9H492 MAP1LC3A Hsap 693b3c0900000008 TRIM25 inhibition of SQSTM1 (Human). NCBITaxon:9606 gomodel:693b3c0900000008/693b3c0900000237 GO:0005543 phospholipid binding GO:0000045 autophagosome assembly GO:0005776 autophagosome false UniProtKB:Q14258 TRIM25 Hsap 693b3c0900000008 TRIM25 inhibition of SQSTM1 (Human). NCBITaxon:9606 gomodel:693b3c0900000008/693b3c0900000250 GO:0061630 ubiquitin protein ligase activity GO:0010507 negative regulation of autophagy GO:0005737 cytoplasm false UniProtKB:O75386 TULP3 Hsap 693b3c0900000051 TULP3 and IFT-A complex mediate transport of GPR161 to primary cilium (Human). NCBITaxon:9606 gomodel:693b3c0900000051/693b3c0900000097 GO:0030674 protein-macromolecule adaptor activity GO:0097499 protein localization to non-motile cilium GO:0005886 plasma membrane false GO:0030991 intraciliary transport particle A 693b3c0900000051 TULP3 and IFT-A complex mediate transport of GPR161 to primary cilium (Human). NCBITaxon:9606 gomodel:693b3c0900000051/693b3c0900000113 GO:0140597 protein carrier activity GO:0097499 protein localization to non-motile cilium false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000051 TULP3 and IFT-A complex mediate transport of GPR161 to primary cilium (Human). NCBITaxon:9606 gomodel:693b3c0900000051/693b3c0900000136 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 693b3c0900000051 TULP3 and IFT-A complex mediate transport of GPR161 to primary cilium (Human). NCBITaxon:9606 gomodel:693b3c0900000051/693b3c0900000149 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000212 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000225 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000233 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P17612 PRKACA Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000265 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P49841 GSK3B Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000275 GO:0004674 protein serine/threonine kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q9Y297 BTRC Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000283 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0016485 protein processing false UniProtKB:P62877 RBX1 Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000291 GO:0061630 ubiquitin protein ligase activity GO:0016485 protein processing false UniProtKB:P10071-PRO_0000406137 GLI3-Transcription_repressor_GLI3R Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000307 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0045879 negative regulation of smoothened signaling pathway GO:0005634 nucleus false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000316 GO:0035591 signaling adaptor activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P10644 PRKAR1A Hsap 693b3c0900000157 GPR161 acts as a negative regulator of smoothened pathway by promoting protein processing of GLI3 into transcription repressor GLI3R (Human). NCBITaxon:9606 gomodel:693b3c0900000157/693b3c0900000323 GO:0008603 cAMP-dependent protein kinase regulator activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000332 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000343 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000351 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P17612 PRKACA Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000361 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P49841 GSK3B Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000370 GO:0004674 protein serine/threonine kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q9Y297 BTRC Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000378 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000386 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000411 GO:0035591 signaling adaptor activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P10644 PRKAR1A Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000418 GO:0008603 cAMP-dependent protein kinase regulator activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P10070 GLI2 Hsap 693b3c0900000331 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI2 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000331/693b3c0900000426 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000435 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63092 GNAS Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000446 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000454 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P17612 PRKACA Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000464 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P49841 GSK3B Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000473 GO:0004674 protein serine/threonine kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q9Y297 BTRC Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000481 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:P62877 RBX1 Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000489 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000505 GO:0035591 signaling adaptor activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P10644 PRKAR1A Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000512 GO:0008603 cAMP-dependent protein kinase regulator activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:P08151 GLI1 Hsap 693b3c0900000434 GPR161 acts as a negative regulator of smoothened pathway by promoting degradation of GLI1 transcription factor (Human). NCBITaxon:9606 gomodel:693b3c0900000434/693b3c0900000520 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:Q99835 SMO Hsap 693b3c0900000716 GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). NCBITaxon:9606 gomodel:693b3c0900000716/693b3c0900000811 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P25098 GRK2 Hsap 693b3c0900000716 GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). NCBITaxon:9606 gomodel:693b3c0900000716/693b3c0900000823 GO:0004703 G protein-coupled receptor kinase activity GO:0035721 intraciliary retrograde transport false GO:0034464 BBSome 693b3c0900000716 GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). NCBITaxon:9606 gomodel:693b3c0900000716/693b3c0900000830 GO:0140597 protein carrier activity GO:0035721 intraciliary retrograde transport false UniProtKB:P49407 ARRB1 Hsap 693b3c0900000716 GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). NCBITaxon:9606 gomodel:693b3c0900000716/693b3c0900000839 GO:0030674 protein-macromolecule adaptor activity GO:0035721 intraciliary retrograde transport false GO:0030992 intraciliary transport particle B 693b3c0900000716 GPR161 is exported from primary cilium in response to smoothened signaling via a beta-arrestin, BBSome and IFT-B complex-dependent mechanism (Human). NCBITaxon:9606 gomodel:693b3c0900000716/693b3c0900000856 GO:0140597 protein carrier activity GO:0035721 intraciliary retrograde transport false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001390 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q99835 SMO Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001401 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P28482 MAPK1 Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001453 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:Q9UMX1 SUFU Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001460 GO:0140311 protein sequestering activity GO:0045879 negative regulation of smoothened signaling pathway GO:0005737 cytoplasm false UniProtKB:P08151 GLI1 Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001475 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:P63096 GNAI1 Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001483 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/693b3c0900001491 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P17612 PRKACA Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/696022cd00001026 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q99835 SMO Hsap 693b3c0900001389 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes GLI1 transcription activator activity and inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001389/696022cd00001031 GO:0140311 protein sequestering activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001502 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q99835 SMO Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001513 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q92630 DYRK2 Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001520 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:Q9UMX1 SUFU Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001527 GO:0140311 protein sequestering activity GO:0045879 negative regulation of smoothened signaling pathway GO:0005737 cytoplasm false UniProtKB:P63096 GNAI1 Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001549 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001557 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P10071-PRO_0000047202 GLI3-Transcription_activator_GLI3 Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/693b3c0900001567 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:Q99835 SMO Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/696022cd00001010 GO:0140311 protein sequestering activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P17612 PRKACA Hsap 693b3c0900001501 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI3 transcription activator activity via phosphorylation of GLI3 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001501/696022cd00001019 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q8N6U8 GPR161 Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001576 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q99835 SMO Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001587 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q92630 DYRK2 Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001594 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:Q9UMX1 SUFU Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001601 GO:0140311 protein sequestering activity GO:0045879 negative regulation of smoothened signaling pathway GO:0005737 cytoplasm false UniProtKB:P63096 GNAI1 Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001615 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001623 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P10070 GLI2 Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/693b3c0900001633 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:P17612 PRKACA Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/696022cd00000993 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q99835 SMO Hsap 693b3c0900001575 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by DYRK2 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:693b3c0900001575/696022cd00000999 GO:0140311 protein sequestering activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q13049 TRIM32 Hsap 693b3c0900001715 Modulation of TRIM32 activity by Seneca virus Protease 3C (Human-Seneca virus) NCBITaxon:9606 gomodel:693b3c0900001715/693b3c0900001716 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q155Z9-PRO_0000446928 Q155Z9-Capsid_protein_VP3 NCBITaxon:686944 693b3c0900001715 Modulation of TRIM32 activity by Seneca virus Protease 3C (Human-Seneca virus) NCBITaxon:9606 gomodel:693b3c0900001715/693b3c0900001725 GO:0039660 structural constituent of virion GO:0039710 cytoplasmic icosahedral capsid assembly GO:0044423 virion component false UniProtKB:Q155Z9-PRO_0000446935 Q155Z9-P3C NCBITaxon:686944 693b3c0900001715 Modulation of TRIM32 activity by Seneca virus Protease 3C (Human-Seneca virus) NCBITaxon:9606 gomodel:693b3c0900001715/693b3c0900001737 GO:0004197 cysteine-type endopeptidase activity GO:0052170 symbiont-mediated suppression of host innate immune response GO:0005737 cytoplasm false UniProtKB:Q99705 MCHR1 Hsap 693b3c0900002472 Signaling by MCH mediated by MCHR1 receptor via G-alpha-i (inhibiting adenylate cyclase)_Feeding (Human) NCBITaxon:9606 gomodel:693b3c0900002472/693b3c0900002473 GO:0030273 melanin-concentrating hormone receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 693b3c0900002472 Signaling by MCH mediated by MCHR1 receptor via G-alpha-i (inhibiting adenylate cyclase)_Feeding (Human) NCBITaxon:9606 gomodel:693b3c0900002472/693b3c0900002474 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 693b3c0900002472 Signaling by MCH mediated by MCHR1 receptor via G-alpha-i (inhibiting adenylate cyclase)_Feeding (Human) NCBITaxon:9606 gomodel:693b3c0900002472/693b3c0900002475 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P20382-PRO_0000019107 PMCH-MCH Hsap 693b3c0900002472 Signaling by MCH mediated by MCHR1 receptor via G-alpha-i (inhibiting adenylate cyclase)_Feeding (Human) NCBITaxon:9606 gomodel:693b3c0900002472/693b3c0900002503 GO:0030354 melanin-concentrating hormone activity GO:0060259 regulation of feeding behavior GO:0005576 extracellular region false UniProtKB:Q99705 MCHR1 Hsap 693b3c0900002518 Signaling by MCH mediated by MCHR1 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-Feeding (Human). NCBITaxon:9606 gomodel:693b3c0900002518/693b3c0900002519 GO:0030273 melanin-concentrating hormone receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 693b3c0900002518 Signaling by MCH mediated by MCHR1 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-Feeding (Human). NCBITaxon:9606 gomodel:693b3c0900002518/693b3c0900002527 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 693b3c0900002518 Signaling by MCH mediated by MCHR1 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-Feeding (Human). NCBITaxon:9606 gomodel:693b3c0900002518/693b3c0900002534 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P20382-PRO_0000019107 PMCH-MCH Hsap 693b3c0900002518 Signaling by MCH mediated by MCHR1 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-Feeding (Human). NCBITaxon:9606 gomodel:693b3c0900002518/693b3c0900002561 GO:0030354 melanin-concentrating hormone activity GO:0060259 regulation of feeding behavior GO:0005576 extracellular region false UniProtKB:Q969V1 MCHR2 Hsap 693b3c0900002636 Signaling by MCH mediated by MCHR2 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)(Human). NCBITaxon:9606 gomodel:693b3c0900002636/693b3c0900002637 GO:0030273 melanin-concentrating hormone receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 693b3c0900002636 Signaling by MCH mediated by MCHR2 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)(Human). NCBITaxon:9606 gomodel:693b3c0900002636/693b3c0900002644 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 693b3c0900002636 Signaling by MCH mediated by MCHR2 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)(Human). NCBITaxon:9606 gomodel:693b3c0900002636/693b3c0900002651 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P20382-PRO_0000019107 PMCH-MCH Hsap 693b3c0900002636 Signaling by MCH mediated by MCHR2 receptor via G-alpha-q/11 (phospholipase c-activating, IP3, DAG)(Human). NCBITaxon:9606 gomodel:693b3c0900002636/693b3c0900002666 GO:0030354 melanin-concentrating hormone activity GO:0007186 G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q8WTR4 GDPD5 Hsap 693b3c0900002985 GDPD5 regulates amyloid-beta processing (Human) NCBITaxon:9606 gomodel:693b3c0900002985/693b3c0900003017 GO:0004620 glycerophospholipase activity GO:1902430 negative regulation of amyloid-beta formation GO:0005886 plasma membrane false UniProtKB:O95980 RECK Hsap 693b3c0900002985 GDPD5 regulates amyloid-beta processing (Human) NCBITaxon:9606 gomodel:693b3c0900002985/693b3c0900003062 GO:0008191 metalloendopeptidase inhibitor activity GO:1902004 positive regulation of amyloid-beta formation GO:0005886 plasma membrane false UniProtKB:O14672 ADAM10 Hsap 693b3c0900002985 GDPD5 regulates amyloid-beta processing (Human) NCBITaxon:9606 gomodel:693b3c0900002985/693b3c0900003107 GO:0004222 metalloendopeptidase activity GO:1902430 negative regulation of amyloid-beta formation GO:0005886 plasma membrane false UniProtKB:P56817 BACE1 Hsap 693b3c0900002985 GDPD5 regulates amyloid-beta processing (Human) NCBITaxon:9606 gomodel:693b3c0900002985/693b3c0900003179 GO:0004175 endopeptidase activity GO:0034205 amyloid-beta formation GO:0005886 plasma membrane false UniProtKB:P05067-PRO_0000000089 APP-S-APP-alpha Hsap 693b3c0900002985 GDPD5 regulates amyloid-beta processing (Human) NCBITaxon:9606 gomodel:693b3c0900002985/693b3c0900003186 GO:0030414 peptidase inhibitor activity GO:1902430 negative regulation of amyloid-beta formation GO:0005576 extracellular region false UniProtKB:O43541 SMAD6 Hsap 693b3c0900005133 SMAD6-SMURF1-mediated degradation of TBX6 (Human) NCBITaxon:9606 gomodel:693b3c0900005133/693b3c0900005134 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9HCE7 SMURF1 Hsap 693b3c0900005133 SMAD6-SMURF1-mediated degradation of TBX6 (Human) NCBITaxon:9606 gomodel:693b3c0900005133/693b3c0900005145 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:O95947 TBX6 Hsap 693b3c0900005133 SMAD6-SMURF1-mediated degradation of TBX6 (Human) NCBITaxon:9606 gomodel:693b3c0900005133/693b3c0900005164 GO:0001216 DNA-binding transcription activator activity GO:0001708 cell fate specification GO:0005634 nucleus false UniProtKB:P13349 MYF5 Hsap 693b3c0900005133 SMAD6-SMURF1-mediated degradation of TBX6 (Human) NCBITaxon:9606 gomodel:693b3c0900005133/693b3c0900005172 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0035914 skeletal muscle cell differentiation GO:0005634 nucleus false UniProtKB:O43541 SMAD6 Hsap 693b3c0900005183 SMAD6-SMURF1-mediated degradation of RUNX2 leading to inhibition of osteoblast differentiation (Human) NCBITaxon:9606 gomodel:693b3c0900005183/693b3c0900005184 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q9HCE7 SMURF1 Hsap 693b3c0900005183 SMAD6-SMURF1-mediated degradation of RUNX2 leading to inhibition of osteoblast differentiation (Human) NCBITaxon:9606 gomodel:693b3c0900005183/693b3c0900005195 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q13950 RUNX2 Hsap 693b3c0900005183 SMAD6-SMURF1-mediated degradation of RUNX2 leading to inhibition of osteoblast differentiation (Human) NCBITaxon:9606 gomodel:693b3c0900005183/693b3c0900005225 GO:0001216 DNA-binding transcription activator activity GO:0001649 osteoblast differentiation GO:0005634 nucleus false UniProtKB:P02818 BGLAP Hsap 693b3c0900005183 SMAD6-SMURF1-mediated degradation of RUNX2 leading to inhibition of osteoblast differentiation (Human) NCBITaxon:9606 gomodel:693b3c0900005183/693b3c0900005234 GO:0008147 structural constituent of bone GO:0001649 osteoblast differentiation GO:0005737 cytoplasm false UniProtKB:O43541 SMAD6 Hsap 693b3c0900005257 Regulation of the TLR signaling by SMAD6-SMURF1 (Human) NCBITaxon:9606 gomodel:693b3c0900005257/693b3c0900005258 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9HCE7 SMURF1 Hsap 693b3c0900005257 Regulation of the TLR signaling by SMAD6-SMURF1 (Human) NCBITaxon:9606 gomodel:693b3c0900005257/693b3c0900005269 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P01137 TGFB1 Hsap 693b3c0900005257 Regulation of the TLR signaling by SMAD6-SMURF1 (Human) NCBITaxon:9606 gomodel:693b3c0900005257/693b3c0900005303 GO:0005125 cytokine activity GO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q9HAU4 SMURF2 Hsap 693b3c0900005257 Regulation of the TLR signaling by SMAD6-SMURF1 (Human) NCBITaxon:9606 gomodel:693b3c0900005257/693b3c0900005311 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q99836 MYD88 Hsap 693b3c0900005257 Regulation of the TLR signaling by SMAD6-SMURF1 (Human) NCBITaxon:9606 gomodel:693b3c0900005257/693b3c0900005324 GO:0035591 signaling adaptor activity GO:0034142 toll-like receptor 4 signaling pathway GO:0005737 cytoplasm false UniProtKB:Q15465-PRO_0000013209 SHH-ShhN Hsap 696022cd00000016 Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). NCBITaxon:9606 gomodel:696022cd00000016/696022cd00000017 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q5VTY9 HHAT Hsap 696022cd00000016 Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). NCBITaxon:9606 gomodel:696022cd00000016/696022cd00000024 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0051604 protein maturation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15465-PRO_0000013208 SHH-SHH Hsap 696022cd00000016 Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). NCBITaxon:9606 gomodel:696022cd00000016/696022cd00000036 GO:0004175 endopeptidase activity GO:0016540 protein autoprocessing GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q15465-PRO_0000013208 SHH-SHH Hsap 696022cd00000016 Protein maturation of SHH by autocleavage, autocholesterylation and palmitoylation by HHAT (Human). NCBITaxon:9606 gomodel:696022cd00000016/696022cd00000045 GO:0140853 cholesterol-protein transferase activity GO:0051604 protein maturation GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q99835 SMO Hsap 696022cd00000056 HSD11B2 and CYP27A1 generate oxysterols that activate SMO (Human). NCBITaxon:9606 gomodel:696022cd00000056/696022cd00000068 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q02318 CYP27A1 Hsap 696022cd00000056 HSD11B2 and CYP27A1 generate oxysterols that activate SMO (Human). NCBITaxon:9606 gomodel:696022cd00000056/696022cd00000136 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen GO:0045880 positive regulation of smoothened signaling pathway true bile_acid_synthesis_sidechain_conjugation UniProtKB:P80365 HSD11B2 Hsap 696022cd00000056 HSD11B2 and CYP27A1 generate oxysterols that activate SMO (Human). NCBITaxon:9606 gomodel:696022cd00000056/696022cd00000144 GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity GO:0045880 positive regulation of smoothened signaling pathway true cortisol_cortisone_shuttle UniProtKB:Q99835 SMO Hsap 696022cd00000124 SMO is translocated in primary cilium via a beta-arrestin and KIF3A-dependent mechanism (Human). NCBITaxon:9606 gomodel:696022cd00000124/696022cd00000125 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P49407 ARRB1 Hsap 696022cd00000124 SMO is translocated in primary cilium via a beta-arrestin and KIF3A-dependent mechanism (Human). NCBITaxon:9606 gomodel:696022cd00000124/696022cd00000154 GO:0030674 protein-macromolecule adaptor activity GO:0097499 protein localization to non-motile cilium false UniProtKB:Q9Y496 KIF3A Hsap 696022cd00000124 SMO is translocated in primary cilium via a beta-arrestin and KIF3A-dependent mechanism (Human). NCBITaxon:9606 gomodel:696022cd00000124/696022cd00000163 GO:0003777 microtubule motor activity GO:0097499 protein localization to non-motile cilium GO:0097730 non-motile cilium false UniProtKB:Q96ND0 MIMS1 Hsap 696022cd00000535 MIMS1 involved in mitochondrial inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Human) NCBITaxon:9606 gomodel:696022cd00000535/696022cd00000536 GO:0008191 metalloendopeptidase inhibitor activity GO:1990627 mitochondrial inner membrane fusion GO:0005743 mitochondrial inner membrane false UniProtKB:Q96TA2 YME1L1 Hsap 696022cd00000535 MIMS1 involved in mitochondrial inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Human) NCBITaxon:9606 gomodel:696022cd00000535/696022cd00000542 GO:0004222 metalloendopeptidase activity GO:1990627 mitochondrial inner membrane fusion GO:0005743 mitochondrial inner membrane false UniProtKB:Q96E52 OMA1 Hsap 696022cd00000535 MIMS1 involved in mitochondrial inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Human) NCBITaxon:9606 gomodel:696022cd00000535/696022cd00000546 GO:0004222 metalloendopeptidase activity GO:1990627 mitochondrial inner membrane fusion GO:0005743 mitochondrial inner membrane false UniProtKB:O60313-PRO_0000253479 OPA1-S-OPA1 Hsap 696022cd00000535 MIMS1 involved in mitochondrial inner membrane fusion in BAT through modulation of YME1L1 metalloendopeptidase activity. (Human) NCBITaxon:9606 gomodel:696022cd00000535/696022cd00000625 GO:0140523 GTPase-dependent fusogenic activity GO:1990627 mitochondrial inner membrane fusion GO:0005758 mitochondrial intermembrane space false UniProtKB:Q9NTG7 SIRT3 Hsap 696022cd00000603 Regulation of the TCA cycle by SIRT3 (Human) NCBITaxon:9606 gomodel:696022cd00000603/696022cd00000604 GO:0034979 NAD-dependent protein lysine deacetylase activity GO:0008053 mitochondrial fusion GO:0005759 mitochondrial matrix false UniProtKB:P40926 MDH2 Hsap 696022cd00000603 Regulation of the TCA cycle by SIRT3 (Human) NCBITaxon:9606 gomodel:696022cd00000603/696022cd00000613 GO:0030060 L-malate dehydrogenase (NAD+) activity GO:0006099 tricarboxylic acid cycle GO:0005759 mitochondrial matrix false UniProtKB:O75390 CS Hsap 696022cd00000603 Regulation of the TCA cycle by SIRT3 (Human) NCBITaxon:9606 gomodel:696022cd00000603/696022cd00000641 GO:0036440 citrate synthase activity GO:0006099 tricarboxylic acid cycle GO:0005759 mitochondrial matrix false UniProtKB:Q96KR6 MIMS2 Hsap 696022cd00000700 Regulation of Heme biosynthesis by MIMS2. (Human) NCBITaxon:9606 gomodel:696022cd00000700/696022cd00000701 GO:0030674 protein-macromolecule adaptor activity GO:0070455 positive regulation of heme biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P50336 PPOX Hsap 696022cd00000700 Regulation of Heme biosynthesis by MIMS2. (Human) NCBITaxon:9606 gomodel:696022cd00000700/696022cd00000706 GO:0004729 protoporphyrinogen oxidase activity, oxygen as acceptor GO:0006783 heme biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:P22830 FECH Hsap 696022cd00000700 Regulation of Heme biosynthesis by MIMS2. (Human) NCBITaxon:9606 gomodel:696022cd00000700/696022cd00000710 GO:0004325 protoporphyrin ferrochelatase activity GO:0006783 heme biosynthetic process GO:0005743 mitochondrial inner membrane false UniProtKB:Q99835 SMO Hsap 696022cd00000812 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00000812/696022cd00000824 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63096 GNAI1 Hsap 696022cd00000812 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00000812/696022cd00000852 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00000812 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00000812/696022cd00000880 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q15465-PRO_0000013209 SHH-ShhN Hsap 696022cd00000812 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00000812/696022cd00000900 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q99835 SMO Hsap 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000909 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000928 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q15465-PRO_0000013209 SHH-ShhN Hsap 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000946 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q9NQ36 SCUBE2 Hsap 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000954 GO:0140597 protein carrier activity GO:0045880 positive regulation of smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:P54826 GAS1 Hsap 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000963 GO:0140597 protein carrier activity GO:0045880 positive regulation of smoothened signaling pathway GO:0005886 plasma membrane false GO:0032991 protein-containing complex 696022cd00000908 SCUBE2, CDON, BOC and GAS1 promote SHH transport to PTCH1 receptor (Human). NCBITaxon:9606 gomodel:696022cd00000908/696022cd00000972 GO:0140597 protein carrier activity GO:0045880 positive regulation of smoothened signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99835 SMO Hsap 696022cd00001146 SMURF1 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001146/696022cd00001147 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00001146 SMURF1 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001146/696022cd00001166 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9HCE7 SMURF1 Hsap 696022cd00001146 SMURF1 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001146/696022cd00001192 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q99835 SMO Hsap 696022cd00001204 SMURF2 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001204/696022cd00001205 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00001204 SMURF2 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001204/696022cd00001216 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9HAU4 SMURF2 Hsap 696022cd00001204 SMURF2 acts as a positive regulator of smoothened signaling by ubiquitinating PTCH1, leading to its degradation (Human). NCBITaxon:9606 gomodel:696022cd00001204/696022cd00001234 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process false UniProtKB:Q99835 SMO Hsap 696022cd00001246 Activation of the smoothened signaling pathway by IHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001246/696022cd00001247 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63096 GNAI1 Hsap 696022cd00001246 Activation of the smoothened signaling pathway by IHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001246/696022cd00001256 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00001246 Activation of the smoothened signaling pathway by IHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001246/696022cd00001266 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q14623-PRO_0000013230 IHH-Indian_hedgehog_protein_N-product Hsap 696022cd00001246 Activation of the smoothened signaling pathway by IHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001246/696022cd00001284 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q99835 SMO Hsap 696022cd00001370 Activation of the smoothened signaling pathway by DHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001370/696022cd00001371 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63096 GNAI1 Hsap 696022cd00001370 Activation of the smoothened signaling pathway by DHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001370/696022cd00001380 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q13635 PTCH1 Hsap 696022cd00001370 Activation of the smoothened signaling pathway by DHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001370/696022cd00001390 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:O43323-PRO_0000013245 DHH-DHH-N Hsap 696022cd00001370 Activation of the smoothened signaling pathway by DHH, which relieves SMO inhibition by PTCH1 (Human). NCBITaxon:9606 gomodel:696022cd00001370/696022cd00001408 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q99835 SMO Hsap 696022cd00001416 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH2 (Human). NCBITaxon:9606 gomodel:696022cd00001416/696022cd00001417 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P63096 GNAI1 Hsap 696022cd00001416 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH2 (Human). NCBITaxon:9606 gomodel:696022cd00001416/696022cd00001426 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9Y6C5 PTCH2 Hsap 696022cd00001416 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH2 (Human). NCBITaxon:9606 gomodel:696022cd00001416/696022cd00001436 GO:0140303 intramembrane lipid carrier activity GO:0045879 negative regulation of smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q15465-PRO_0000013209 SHH-ShhN Hsap 696022cd00001416 Activation of the smoothened signaling pathway by SHH, which relieves SMO inhibition by PTCH2 (Human). NCBITaxon:9606 gomodel:696022cd00001416/696022cd00001454 GO:0016015 morphogen activity GO:0007224 smoothened signaling pathway GO:0005576 extracellular region false UniProtKB:Q8N6U8 GPR161 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001524 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q99835 SMO Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001535 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9UMX1 SUFU Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001549 GO:0140311 protein sequestering activity GO:0045879 negative regulation of smoothened signaling pathway GO:0005737 cytoplasm false UniProtKB:P63096 GNAI1 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001563 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001571 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P10070 GLI2 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001581 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:P17612 PRKACA Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001591 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q99835 SMO Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001597 GO:0140311 protein sequestering activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P06493 CDK1 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001627 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:Q6PHR2 ULK3 Hsap 696022cd00001523 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by ULK3 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001523/696022cd00001634 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:Q8N6U8 GPR161 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001646 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q99835 SMO Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001657 GO:0004930 G protein-coupled receptor activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9UMX1 SUFU Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001664 GO:0140311 protein sequestering activity GO:0045879 negative regulation of smoothened signaling pathway GO:0005737 cytoplasm false UniProtKB:P63096 GNAI1 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001676 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001684 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:P10070 GLI2 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001694 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0007224 smoothened signaling pathway GO:0005634 nucleus false UniProtKB:P17612 PRKACA Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001704 GO:0004691 cAMP-dependent protein kinase activity GO:0045879 negative regulation of smoothened signaling pathway false UniProtKB:Q99835 SMO Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001710 GO:0140311 protein sequestering activity GO:0007224 smoothened signaling pathway GO:0098804 non-motile cilium membrane false UniProtKB:Q9NRP7 STK36 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001720 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway GO:0097542 ciliary tip false UniProtKB:Q96C45 ULK4 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001729 GO:0030674 protein-macromolecule adaptor activity GO:0045880 positive regulation of smoothened signaling pathway GO:0097542 ciliary tip false UniProtKB:P06493 CDK1 Hsap 696022cd00001645 Smoothened (SMO) activation by cholesterol triggers a signaling that promotes (1) GLI2 transcription activator activity via phosphorylation of GLI2 by STK36 and (2) inhibits the smoothened signaling inhibitor GPR161 (Human). NCBITaxon:9606 gomodel:696022cd00001645/696022cd00001740 GO:0004674 protein serine/threonine kinase activity GO:0045880 positive regulation of smoothened signaling pathway false UniProtKB:P13725 OSM Hsap 696022cd00002138 OSM signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002138/696022cd00002139 GO:0005125 cytokine activity GO:0038165 oncostatin-M-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 696022cd00002138 OSM signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002138/696022cd00002148 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0038165 oncostatin-M-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P23458 JAK1 Hsap 696022cd00002138 OSM signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002138/696022cd00002169 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 696022cd00002138 OSM signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002138/696022cd00002190 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false GO:0140370 type II oncostatin-M receptor complex 696022cd00002138 OSM signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002138/69729a3800000169 GO:0004924 oncostatin-M receptor activity GO:0038165 oncostatin-M-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:P15289 ARSA Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/696022cd00002297 GO:0004098 cerebroside-sulfatase activity GO:0030149 sphingolipid catabolic process GO:0036021 endolysosome lumen true glycosphingolipid_lysosomal_degradation UniProtKB:P07602-PRO_0000031620 PSAP-Saposin-B Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/696022cd00002431 GO:7770043 lipid chaperone activity GO:0030149 sphingolipid catabolic process GO:0160317 endolysosomal intralumenal vesicle membrane false UniProtKB:P07602-PRO_0000031617 PSAP-Saposin-A Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/69729a3800003482 GO:7770043 lipid chaperone activity GO:0030149 sphingolipid catabolic process GO:0160317 endolysosomal intralumenal vesicle membrane false UniProtKB:P54803 GALC Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/69729a3800003499 GO:0004336 galactosylceramidase activity GO:0030149 sphingolipid catabolic process GO:0036021 endolysosome lumen true glycosphingolipid_lysosomal_degradation UniProtKB:P07602-PRO_0000031624 PSAP-Saposin-D Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/69729a3800005901 GO:7770043 lipid chaperone activity GO:0030149 sphingolipid catabolic process GO:0160317 endolysosomal intralumenal vesicle membrane false UniProtKB:Q13510 ASAH1 Hsap 696022cd00002259 Endolysosomal degradation of galactocerebroside sulfate by arylsulfatase A (Human) NCBITaxon:9606 gomodel:696022cd00002259/69729a3800006622 GO:0017040 N-acylsphingosine amidohydrolase activity GO:0030149 sphingolipid catabolic process GO:0036021 endolysosome lumen true glycosphingolipid_lysosomal_degradation UniProtKB:P13725 OSM Hsap 696022cd00002481 OSM signaling pathway involving IL6ST-OSMR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002481/696022cd00002482 GO:0005125 cytokine activity GO:0038165 oncostatin-M-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 696022cd00002481 OSM signaling pathway involving IL6ST-OSMR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002481/696022cd00002489 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0038165 oncostatin-M-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P23458 JAK1 Hsap 696022cd00002481 OSM signaling pathway involving IL6ST-OSMR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002481/696022cd00002510 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 696022cd00002481 OSM signaling pathway involving IL6ST-OSMR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002481/696022cd00002521 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false GO:0005900 type I oncostatin-M receptor complex 696022cd00002481 OSM signaling pathway involving IL6ST-OSMR receptor complex (human) NCBITaxon:9606 gomodel:696022cd00002481/696022cd00002572 GO:0004924 oncostatin-M receptor activity GO:0038165 oncostatin-M-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q6EBC2 IL31 Hsap 696022cd00002619 IL31 signaling pathway involving IL31RA-OSMR (human) NCBITaxon:9606 gomodel:696022cd00002619/696022cd00002620 GO:0005125 cytokine activity GO:0019221 cytokine-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 696022cd00002619 IL31 signaling pathway involving IL31RA-OSMR (human) NCBITaxon:9606 gomodel:696022cd00002619/696022cd00002627 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0019221 cytokine-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P23458 JAK1 Hsap 696022cd00002619 IL31 signaling pathway involving IL31RA-OSMR (human) NCBITaxon:9606 gomodel:696022cd00002619/696022cd00002634 GO:0004713 protein tyrosine kinase activity GO:0019221 cytokine-mediated signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q8NI17 IL31RA Hsap 696022cd00002619 IL31 signaling pathway involving IL31RA-OSMR (human) NCBITaxon:9606 gomodel:696022cd00002619/696022cd00002717 GO:0004896 cytokine receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q99650 OSMR Hsap 696022cd00002619 IL31 signaling pathway involving IL31RA-OSMR (human) NCBITaxon:9606 gomodel:696022cd00002619/696022cd00002729 GO:0015026 coreceptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:Q96P20 NLRP3 Hsap 696022cd00003683 ZNFX1 inhibits NLRP3 inflammasome. (Human) NCBITaxon:9606 gomodel:696022cd00003683/696022cd00003684 GO:0140608 cysteine-type endopeptidase activator activity GO:0044546 NLRP3 inflammasome complex assembly GO:0032588 trans-Golgi network membrane false UniProtKB:Q9P2E3 ZNFX1 Hsap 696022cd00003683 ZNFX1 inhibits NLRP3 inflammasome. (Human) NCBITaxon:9606 gomodel:696022cd00003683/696022cd00003744 GO:0140311 protein sequestering activity GO:1900226 negative regulation of NLRP3 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P29466 CASP1 Hsap 696022cd00003683 ZNFX1 inhibits NLRP3 inflammasome. (Human) NCBITaxon:9606 gomodel:696022cd00003683/696022cd00003780 GO:0004197 cysteine-type endopeptidase activity GO:1900227 positive regulation of NLRP3 inflammasome complex assembly GO:0005829 cytosol false UniProtKB:P24863 CCNC Hsap 696022cd00003836 Regulation of NOTCH1 by the Cyclin C-CDK19 pair (Human) NCBITaxon:9606 gomodel:696022cd00003836/696022cd00003861 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q9BWU1 CDK19 Hsap 696022cd00003836 Regulation of NOTCH1 by the Cyclin C-CDK19 pair (Human) NCBITaxon:9606 gomodel:696022cd00003836/696022cd00003868 GO:0004674 protein serine/threonine kinase activity GO:0006357 regulation of transcription by RNA polymerase II GO:0005634 nucleus false UniProtKB:P46531 NOTCH1 Hsap 696022cd00003836 Regulation of NOTCH1 by the Cyclin C-CDK19 pair (Human) NCBITaxon:9606 gomodel:696022cd00003836/696022cd00003878 GO:0003713 transcription coactivator activity GO:0007219 Notch signaling pathway GO:0005634 nucleus false UniProtKB:P36969 GPX4 Hsap 696022cd00003889 TRIM36-mediated inhibition of the GPX4-NRF2 axis (Human) NCBITaxon:9606 gomodel:696022cd00003889/696022cd00003890 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity GO:0110076 negative regulation of ferroptosis false UniProtKB:Q9NQ86 TRIM36 Hsap 696022cd00003889 TRIM36-mediated inhibition of the GPX4-NRF2 axis (Human) NCBITaxon:9606 gomodel:696022cd00003889/696022cd00003948 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q9Y261 FOXA2 Hsap 696022cd00003889 TRIM36-mediated inhibition of the GPX4-NRF2 axis (Human) NCBITaxon:9606 gomodel:696022cd00003889/696022cd00003955 GO:0003700 DNA-binding transcription factor activity GO:0110076 negative regulation of ferroptosis GO:0005634 nucleus false UniProtKB:Q16236 NFE2L2 Hsap 696022cd00003889 TRIM36-mediated inhibition of the GPX4-NRF2 axis (Human) NCBITaxon:9606 gomodel:696022cd00003889/696022cd00003967 GO:0003700 DNA-binding transcription factor activity GO:0110076 negative regulation of ferroptosis GO:0005634 nucleus false UniProtKB:Q16619 CTF1 Hsap 69729a3800000296 CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:69729a3800000296/69729a3800000297 GO:0005125 cytokine activity GO:0038165 oncostatin-M-mediated signaling pathway GO:0005576 extracellular region false UniProtKB:P40763 STAT3 Hsap 69729a3800000296 CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:69729a3800000296/69729a3800000304 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0019221 cytokine-mediated signaling pathway GO:0005634 nucleus false UniProtKB:P23458 JAK1 Hsap 69729a3800000296 CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:69729a3800000296/69729a3800000311 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60674 JAK2 Hsap 69729a3800000296 CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:69729a3800000296/69729a3800000320 GO:0004713 protein tyrosine kinase activity GO:0007259 cell surface receptor signaling pathway via JAK-STAT GO:0009898 cytoplasmic side of plasma membrane false GO:0140370 type II oncostatin-M receptor complex 69729a3800000296 CTF1 signaling pathway involving IL6ST-LIFR receptor complex (human) NCBITaxon:9606 gomodel:69729a3800000296/69729a3800000346 GO:0004924 oncostatin-M receptor activity GO:0019221 cytokine-mediated signaling pathway GO:0005886 plasma membrane false UniProtKB:O60307 MAST3 Hsap 69729a3800000481 MAST3 kinase regulates ARPP19 phosphatase activity and is down-regulated by PKA NCBITaxon:9606 gomodel:69729a3800000481/69729a3800000482 GO:0106310 protein serine kinase activity GO:0006468 protein phosphorylation false UniProtKB:P56211 ARPP19 Hsap 69729a3800000481 MAST3 kinase regulates ARPP19 phosphatase activity and is down-regulated by PKA NCBITaxon:9606 gomodel:69729a3800000481/69729a3800001005 GO:0004864 protein phosphatase inhibitor activity GO:0010923 negative regulation of phosphatase activity false UniProtKB:P17612 PRKACA Hsap 69729a3800000481 MAST3 kinase regulates ARPP19 phosphatase activity and is down-regulated by PKA NCBITaxon:9606 gomodel:69729a3800000481/69729a3800001011 GO:0004674 protein serine/threonine kinase activity GO:0006468 protein phosphorylation false GO:0008287 protein serine/threonine phosphatase complex 69729a3800000481 MAST3 kinase regulates ARPP19 phosphatase activity and is down-regulated by PKA NCBITaxon:9606 gomodel:69729a3800000481/69729a3800001020 GO:0004721 phosphoprotein phosphatase activity false UniProtKB:P28482 MAPK1 Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800001686 GO:0004707 MAP kinase activity GO:0043415 positive regulation of skeletal muscle tissue regeneration GO:0005829 cytosol false UniProtKB:Q96GS6 ABHD17A Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800001839 GO:0008474 palmitoyl-(protein) hydrolase activity GO:0031339 negative regulation of vesicle fusion GO:0010008 endosome membrane false UniProtKB:P16671 CD36 Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800002508 GO:0038024 cargo receptor activity GO:0015911 long-chain fatty acid import across plasma membrane GO:0005886 plasma membrane false UniProtKB:Q5W0Z9 ZDHHC20 Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800002527 GO:0019706 protein-cysteine S-palmitoyltransferase activity GO:0051604 protein maturation GO:0030659 cytoplasmic vesicle membrane false UniProtKB:P16671 CD36 Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800002542 GO:0038023 signaling receptor activity GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0005886 plasma membrane false UniProtKB:P05019 IGF1 Hsap 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800002699 GO:0008083 growth factor activity GO:0048009 insulin-like growth factor receptor signaling pathway GO:0005576 extracellular region false GO:0031201 SNARE complex 69729a3800001528 CD36 transport to the plasma membrane for muscle regeneration (Human) NCBITaxon:9606 gomodel:69729a3800001528/69729a3800003578 GO:0140522 fusogenic activity GO:0006906 vesicle fusion GO:0016020 membrane false UniProtKB:P17405 SMPD1 Hsap 69729a3800002480 Endolysosomal degradation of SM enabled by SMPD1 Hsap NCBITaxon:9606 gomodel:69729a3800002480/69729a3800002481 GO:0061750 acid sphingomyelin phosphodiesterase activity GO:0006685 sphingomyelin catabolic process GO:0036021 endolysosome lumen true glycosphingolipid_lysosomal_degradation UniProtKB:Q13510 ASAH1 Hsap 69729a3800002480 Endolysosomal degradation of SM enabled by SMPD1 Hsap NCBITaxon:9606 gomodel:69729a3800002480/69729a3800002535 GO:0017040 N-acylsphingosine amidohydrolase activity GO:0006685 sphingomyelin catabolic process GO:0036021 endolysosome lumen true glycosphingolipid_lysosomal_degradation UniProtKB:P07602-PRO_0000031624 PSAP-Saposin-D Hsap 69729a3800002480 Endolysosomal degradation of SM enabled by SMPD1 Hsap NCBITaxon:9606 gomodel:69729a3800002480/69729a3800002548 GO:7770043 lipid chaperone activity GO:0006685 sphingomyelin catabolic process GO:0036021 endolysosome lumen false UniProtKB:P01178-PRO_0000020496 OXT-Neurophysin_1 Hsap 69729a3800003258 Processing, maturation and transport of oxytocin (OXT) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003258/69729a3800003259 GO:0140597 protein carrier activity GO:0009914 hormone transport GO:0030141 secretory granule false UniProtKB:P19021 PAM Hsap 69729a3800003258 Processing, maturation and transport of oxytocin (OXT) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003258/69729a3800003268 GO:0004504 peptidylglycine monooxygenase activity GO:0001519 peptide amidation false UniProtKB:P19021 PAM Hsap 69729a3800003258 Processing, maturation and transport of oxytocin (OXT) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003258/69729a3800003277 GO:0004598 peptidylamidoglycolate lyase activity GO:0001519 peptide amidation false UniProtKB:P16519 PCSK2 Hsap 69729a3800003258 Processing, maturation and transport of oxytocin (OXT) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003258/69729a3800003288 GO:0004252 serine-type endopeptidase activity GO:0016486 peptide hormone processing false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800003258 Processing, maturation and transport of oxytocin (OXT) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003258/69729a3800003296 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:P01185-PRO_0000020516 AVP-Neurophysin_2 Hsap 69729a3800003304 Processing, maturation and transport of vasopressin (AVP) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003304/69729a3800003305 GO:0140597 protein carrier activity GO:0009914 hormone transport GO:0030141 secretory granule false UniProtKB:P19021 PAM Hsap 69729a3800003304 Processing, maturation and transport of vasopressin (AVP) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003304/69729a3800003314 GO:0004504 peptidylglycine monooxygenase activity GO:0001519 peptide amidation false UniProtKB:P19021 PAM Hsap 69729a3800003304 Processing, maturation and transport of vasopressin (AVP) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003304/69729a3800003323 GO:0004598 peptidylamidoglycolate lyase activity GO:0001519 peptide amidation false UniProtKB:P29120 PCSK1 Hsap 69729a3800003304 Processing, maturation and transport of vasopressin (AVP) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003304/69729a3800003334 GO:0004252 serine-type endopeptidase activity GO:0016486 peptide hormone processing false UniProtKB:P01185-PRO_0000020515 AVP-Arg-vasopressin Hsap 69729a3800003304 Processing, maturation and transport of vasopressin (AVP) hormone (Human). NCBITaxon:9606 gomodel:69729a3800003304/69729a3800003350 GO:0005179 hormone activity GO:0070295 renal water absorption GO:0005576 extracellular region false UniProtKB:Q13618 CUL3 Hsap 69729a3800003422 CUL3/KLHL6/RBX1 complex ubiquitinates RC3H2 leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:69729a3800003422/69729a3800003423 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 69729a3800003422 CUL3/KLHL6/RBX1 complex ubiquitinates RC3H2 leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:69729a3800003422/69729a3800003430 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q8WZ60 KLHL6 Hsap 69729a3800003422 CUL3/KLHL6/RBX1 complex ubiquitinates RC3H2 leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:69729a3800003422/69729a3800003461 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9HBD1 RC3H2 Hsap 69729a3800003422 CUL3/KLHL6/RBX1 complex ubiquitinates RC3H2 leading to its proteasomal degradation (Human) NCBITaxon:9606 gomodel:69729a3800003422/69729a3800003474 GO:0003723 RNA binding GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9HB89 NMUR1 Hsap 69729a3800004117 NMUR1-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) inflammatory response (Human) NCBITaxon:9606 gomodel:69729a3800004117/69729a3800004118 GO:0008188 neuropeptide receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800004117 NMUR1-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) inflammatory response (Human) NCBITaxon:9606 gomodel:69729a3800004117/69729a3800004119 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69729a3800004117 NMUR1-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) inflammatory response (Human) NCBITaxon:9606 gomodel:69729a3800004117/69729a3800004120 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004117 NMUR1-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) inflammatory response (Human) NCBITaxon:9606 gomodel:69729a3800004117/69729a3800004148 GO:0160041 neuropeptide activity GO:0007218 neuropeptide signaling pathway GO:0005576 extracellular region false UniProtKB:Q9GZQ4 NMUR2 Hsap 69729a3800004304 NMUR2-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) NCBITaxon:9606 gomodel:69729a3800004304/69729a3800004305 GO:0008188 neuropeptide receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800004304 NMUR2-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) NCBITaxon:9606 gomodel:69729a3800004304/69729a3800004306 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69729a3800004304 NMUR2-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) NCBITaxon:9606 gomodel:69729a3800004304/69729a3800004307 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004304 NMUR2-mediated signaling via G-alpha-i (inhibiting adenylate cyclase) following NMU-25 (Human) NCBITaxon:9606 gomodel:69729a3800004304/69729a3800004332 GO:0160041 neuropeptide activity GO:0007218 neuropeptide signaling pathway GO:0005576 extracellular region false UniProtKB:P51178 PLCD1 Hsap 69729a3800004445 NMUR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004445/69729a3800004446 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P29992 GNA11 Hsap 69729a3800004445 NMUR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004445/69729a3800004458 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9HB89 NMUR1 Hsap 69729a3800004445 NMUR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004445/69729a3800004466 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004445 NMUR1-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004445/69729a3800004476 GO:0160041 neuropeptide activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P51178 PLCD1 Hsap 69729a3800004523 NMUR2-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004523/69729a3800004524 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P29992 GNA11 Hsap 69729a3800004523 NMUR2-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004523/69729a3800004534 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9GZQ4 NMUR2 Hsap 69729a3800004523 NMUR2-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004523/69729a3800004542 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004523 NMUR2-mediated signaling via G-alpha-11 (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004523/69729a3800004550 GO:0160041 neuropeptide activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P51178 PLCD1 Hsap 69729a3800004564 NMUR2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004564/69729a3800004565 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P50148 GNAQ Hsap 69729a3800004564 NMUR2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004564/69729a3800004575 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9GZQ4 NMUR2 Hsap 69729a3800004564 NMUR2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004564/69729a3800004583 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004564 NMUR2-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004564/69729a3800004591 GO:0160041 neuropeptide activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:P51178 PLCD1 Hsap 69729a3800004605 NMUR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004605/69729a3800004606 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P50148 GNAQ Hsap 69729a3800004605 NMUR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004605/69729a3800004616 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q9HB89 NMUR1 Hsap 69729a3800004605 NMUR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004605/69729a3800004624 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P48645-PRO_0000019773 NMU-NmU-25 Hsap 69729a3800004605 NMUR1-mediated signaling via G-alpha-q (phospholipase c-activating, IP3) following NMU-25 binding (Human). NCBITaxon:9606 gomodel:69729a3800004605/69729a3800004632 GO:0160041 neuropeptide activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005576 extracellular region false UniProtKB:Q01970 PLCB3 Hsap 69729a3800004953 Inhibition of the oxytocin receptor (OXTR) by progesterone (Human). NCBITaxon:9606 gomodel:69729a3800004953/69729a3800004955 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 69729a3800004953 Inhibition of the oxytocin receptor (OXTR) by progesterone (Human). NCBITaxon:9606 gomodel:69729a3800004953/69729a3800004956 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800004953 Inhibition of the oxytocin receptor (OXTR) by progesterone (Human). NCBITaxon:9606 gomodel:69729a3800004953/69729a3800005010 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:P30559 OXTR Hsap 69729a3800004953 Inhibition of the oxytocin receptor (OXTR) by progesterone (Human). NCBITaxon:9606 gomodel:69729a3800004953/69729a3800005017 GO:0004990 oxytocin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 69729a3800005034 OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005034/69729a3800005035 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 69729a3800005034 OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005034/69729a3800005036 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800005034 OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005034/69729a3800005055 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:P30559 OXTR Hsap 69729a3800005034 OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005034/69729a3800005062 GO:0004990 oxytocin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15139 PRKD1 Hsap 69729a3800005034 OXTR phosphorylation by PRKD1 promotes G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005034/69729a3800005080 GO:0004674 protein serine/threonine kinase activity GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway false UniProtKB:Q01970 PLCB3 Hsap 69729a3800005091 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005091/69729a3800005092 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 69729a3800005091 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005091/69729a3800005093 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800005091 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005091/69729a3800005112 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:P30559 OXTR Hsap 69729a3800005091 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69729a3800005091/69729a3800005119 GO:0004990 oxytocin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800005136 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69729a3800005136/69729a3800005138 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 69729a3800005136 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69729a3800005136/69729a3800005139 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P30559 OXTR Hsap 69729a3800005136 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69729a3800005136/69729a3800005167 GO:0004990 oxytocin receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800005136 Oxytocin (OXT) binding to its receptor OXTR regulates social behavior via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69729a3800005136/69729a3800005179 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:Q9H3F6 KCTD10 Hsap 69729a3800005900 KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) NCBITaxon:9606 gomodel:69729a3800005900/69729a3800005916 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 69729a3800005900 KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) NCBITaxon:9606 gomodel:69729a3800005900/69729a3800005923 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 69729a3800005900 KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) NCBITaxon:9606 gomodel:69729a3800005900/69729a3800005930 GO:0160072 ubiquitin ligase complex scaffold activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:Q9UPY5 SLC7A11 Hsap 69729a3800005900 KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) NCBITaxon:9606 gomodel:69729a3800005900/69729a3800005941 GO:0015327 cystine:glutamate antiporter activity GO:0015813 L-glutamate transmembrane transport GO:0005886 plasma membrane false UniProtKB:Q9UMW8 USP18 Hsap 69729a3800005900 KCTD10-mediated degradation of SLC7A11 leading to regulation of ferroptosis (Human) NCBITaxon:9606 gomodel:69729a3800005900/69729a3800005955 GO:0004843 cysteine-type deubiquitinase activity GO:0016579 protein deubiquitination GO:0005737 cytoplasm false UniProtKB:P19021 PAM Hsap 69729a3800006347 Processing, maturation and transport of corticotropin-releasing hormone (CRH) hormone (Human) NCBITaxon:9606 gomodel:69729a3800006347/69729a3800006357 GO:0004504 peptidylglycine monooxygenase activity GO:0001519 peptide amidation false UniProtKB:P19021 PAM Hsap 69729a3800006347 Processing, maturation and transport of corticotropin-releasing hormone (CRH) hormone (Human) NCBITaxon:9606 gomodel:69729a3800006347/69729a3800006366 GO:0004598 peptidylamidoglycolate lyase activity GO:0001519 peptide amidation false UniProtKB:P16519 PCSK2 Hsap 69729a3800006347 Processing, maturation and transport of corticotropin-releasing hormone (CRH) hormone (Human) NCBITaxon:9606 gomodel:69729a3800006347/69729a3800006376 GO:0004252 serine-type endopeptidase activity GO:0016486 peptide hormone processing false UniProtKB:P06850 CRH Hsap 69729a3800006347 Processing, maturation and transport of corticotropin-releasing hormone (CRH) hormone (Human) NCBITaxon:9606 gomodel:69729a3800006347/69729a3800006395 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P34998 CRHR1 Hsap 69729a3800006407 "Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006407/69729a3800006408 GO:0015056 corticotrophin-releasing factor receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800006407 "Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006407/69729a3800006410 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800006407 "Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006407/69729a3800006412 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P06850 CRH Hsap 69729a3800006407 "Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006407/69729a3800006439 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 69729a3800006407 "Whole body adaptation to stress following activation of CRHR1 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006407/69729a3800006453 GO:0005179 hormone activity GO:0032099 negative regulation of appetite GO:0005576 extracellular region false UniProtKB:P34998 CRHR1 Hsap 69729a3800006465 CRHBP inhibits corticotropin-releasing hormone activity (CRH) (Human). NCBITaxon:9606 gomodel:69729a3800006465/69729a3800006466 GO:0015056 corticotrophin-releasing factor receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P06850 CRH Hsap 69729a3800006465 CRHBP inhibits corticotropin-releasing hormone activity (CRH) (Human). NCBITaxon:9606 gomodel:69729a3800006465/69729a3800006495 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P24387 CRHBP Hsap 69729a3800006465 CRHBP inhibits corticotropin-releasing hormone activity (CRH) (Human). NCBITaxon:9606 gomodel:69729a3800006465/69729a3800006520 GO:0141069 receptor ligand inhibitor activity GO:0051460 negative regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P50148 GNAQ Hsap 69729a3800006530 Oxytocin (OXT) binding to its receptor OXTR indirectly inhibits corticotropin release (Human). NCBITaxon:9606 gomodel:69729a3800006530/69729a3800006532 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P01178-PRO_0000020495 OXT-Oxytocin Hsap 69729a3800006530 Oxytocin (OXT) binding to its receptor OXTR indirectly inhibits corticotropin release (Human). NCBITaxon:9606 gomodel:69729a3800006530/69729a3800006551 GO:0005185 neurohypophyseal hormone activity GO:0035176 social behavior GO:0005576 extracellular region false UniProtKB:P30559 OXTR Hsap 69729a3800006530 Oxytocin (OXT) binding to its receptor OXTR indirectly inhibits corticotropin release (Human). NCBITaxon:9606 gomodel:69729a3800006530/69729a3800006558 GO:0004990 oxytocin receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P24387 CRHBP Hsap 69729a3800006530 Oxytocin (OXT) binding to its receptor OXTR indirectly inhibits corticotropin release (Human). NCBITaxon:9606 gomodel:69729a3800006530/69729a3800006573 GO:0141069 receptor ligand inhibitor activity GO:0051460 negative regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:Q13324 CRHR2 Hsap 69729a3800006791 "Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006791/69729a3800006792 GO:0015056 corticotrophin-releasing factor receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800006791 "Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006791/69729a3800006794 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800006791 "Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006791/69729a3800006796 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P06850 CRH Hsap 69729a3800006791 "Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006791/69729a3800006821 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 69729a3800006791 "Whole body adaptation to stress following activation of CRHR2 by CRH, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006791/69729a3800006834 GO:0005179 hormone activity GO:0032099 negative regulation of appetite GO:0005576 extracellular region false UniProtKB:P34998 CRHR1 Hsap 69729a3800006846 "Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006846/69729a3800006847 GO:0015056 corticotrophin-releasing factor receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800006846 "Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006846/69729a3800006849 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800006846 "Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006846/69729a3800006851 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P55089 UCN Hsap 69729a3800006846 "Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006846/69729a3800006876 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 69729a3800006846 "Whole body adaptation to stress following activation of CRHR1 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006846/69729a3800006889 GO:0005179 hormone activity GO:0032099 negative regulation of appetite GO:0005576 extracellular region false UniProtKB:Q13324 CRHR2 Hsap 69729a3800006901 "Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006901/69729a3800006902 GO:0015056 corticotrophin-releasing factor receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800006901 "Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006901/69729a3800006904 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800006901 "Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006901/69729a3800006906 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P55089 UCN Hsap 69729a3800006901 "Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006901/69729a3800006931 GO:0017045 corticotropin-releasing hormone activity GO:0051461 positive regulation of corticotropin secretion GO:0005576 extracellular region false UniProtKB:P01189-PRO_0000024969 POMC-Corticotropin Hsap 69729a3800006901 "Whole body adaptation to stress following activation of CRHR2 by UCN, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800006901/69729a3800006944 GO:0005179 hormone activity GO:0032099 negative regulation of appetite GO:0005576 extracellular region false UniProtKB:Q13324 CRHR2 Hsap 69729a3800007299 "Whole body adaptation to stress following activation of CRHR2 by UCN3, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007299/69729a3800007300 GO:0008528 G protein-coupled peptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800007299 "Whole body adaptation to stress following activation of CRHR2 by UCN3, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007299/69729a3800007302 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800007299 "Whole body adaptation to stress following activation of CRHR2 by UCN3, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007299/69729a3800007304 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q969E3 UCN3 Hsap 69729a3800007299 "Whole body adaptation to stress following activation of CRHR2 by UCN3, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007299/69729a3800007329 GO:0005184 neuropeptide hormone activity GO:0097009 energy homeostasis GO:0005576 extracellular region false UniProtKB:Q13324 CRHR2 Hsap 69729a3800007354 "Whole body adaptation to stress following activation of CRHR2 by UCN2, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007354/69729a3800007355 GO:0008528 G protein-coupled peptide receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69729a3800007354 "Whole body adaptation to stress following activation of CRHR2 by UCN2, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007354/69729a3800007357 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69729a3800007354 "Whole body adaptation to stress following activation of CRHR2 by UCN2, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007354/69729a3800007359 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q96RP3 UCN2 Hsap 69729a3800007354 "Whole body adaptation to stress following activation of CRHR2 by UCN2, leading to signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) (Human)." NCBITaxon:9606 gomodel:69729a3800007354/69729a3800007384 GO:0005184 neuropeptide hormone activity GO:0051866 general adaptation syndrome GO:0005576 extracellular region false UniProtKB:Q9Y2W3 SLC45A1 Hsap 69729a3800008725 SLC45A1 mediates hexose efflux from lysosomes and is required for V-ATPase activity (Human). NCBITaxon:9606 gomodel:69729a3800008725/69729a3800008726 GO:0015149 hexose transmembrane transporter activity GO:0170063 transmembrane transport from lysosomal lumen to cytosol GO:0005765 lysosomal membrane false GO:0046611 lysosomal proton-transporting V-type ATPase complex 69729a3800008725 SLC45A1 mediates hexose efflux from lysosomes and is required for V-ATPase activity (Human). NCBITaxon:9606 gomodel:69729a3800008725/69729a3800008741 GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:1902600 proton transmembrane transport GO:0005765 lysosomal membrane false GO:0071986 Ragulator complex 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000130 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000161 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000174 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000187 GO:0043495 protein-membrane adaptor activity GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000202 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000215 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000228 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false GO:0046611 lysosomal proton-transporting V-type ATPase complex 698e557b00000129 The V-ATPase complex promotes the guanyl-nucleotide exchange factor activity of the Ragulator complex during mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000129/698e557b00000367 GO:0160124 guanyl nucleotide exchange factor activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false GO:0071986 Ragulator complex 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000392 GO:0005085 guanyl-nucleotide exchange factor activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000402 GO:0005525 GTP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000413 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q7L523 RRAGA Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000421 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q9HB90 RRAGC Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000436 GO:0043495 protein-membrane adaptor activity GO:0061462 protein localization to lysosome GO:0005765 lysosomal membrane false UniProtKB:Q15382 RHEB Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000449 GO:0043539 protein serine/threonine kinase activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P42345 MTOR Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000462 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false GO:0046611 lysosomal proton-transporting V-type ATPase complex 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000504 GO:0160124 guanyl nucleotide exchange factor activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q9NZ42 PSENEN Hsap 698e557b00000391 PSENEN binds metformin in response to calorie restriction and inhibits the V-ATPase complex, inhibiting mTORC1 signaling (Human). NCBITaxon:9606 gomodel:698e557b00000391/698e557b00000524 GO:0140678 molecular function inhibitor activity GO:0042149 cellular response to glucose starvation false GO:0046611 lysosomal proton-transporting V-type ATPase complex 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001250 GO:0160124 guanyl nucleotide exchange factor activator activity GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75386 TULP3 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001268 GO:0030674 protein-macromolecule adaptor activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:Q96EB6 SIRT1 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001279 GO:0141208 NAD-dependent protein lysine delactylase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:O15169 AXIN1 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001294 GO:0030674 protein-macromolecule adaptor activity GO:1904262 negative regulation of TORC1 signaling GO:0005770 late endosome false UniProtKB:Q15831 STK11 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001307 GO:0106310 protein serine kinase activity GO:1904262 negative regulation of TORC1 signaling GO:0005770 late endosome false UniProtKB:Q13131 PRKAA1 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001319 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:O15169 AXIN1 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001328 GO:0030674 protein-macromolecule adaptor activity GO:1904262 negative regulation of TORC1 signaling GO:0005770 late endosome false UniProtKB:Q15831 STK11 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001342 GO:0106310 protein serine kinase activity GO:1904262 negative regulation of TORC1 signaling GO:0005770 late endosome false UniProtKB:P54646 PRKAA2 Hsap 698e557b00001137 Inhibition of mTORC1 signaling by the AXIN1-STK11 axis in response to glucose starvation (Human). NCBITaxon:9606 gomodel:698e557b00001137/698e557b00001353 GO:0004679 AMP-activated protein kinase activity GO:1904262 negative regulation of TORC1 signaling false UniProtKB:P42345 MTOR Hsap 69a0c46f00001110 FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) NCBITaxon:9606 gomodel:69a0c46f00001110/69a0c46f00001229 GO:0004674 protein serine/threonine kinase activity GO:0038202 TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:P23443 RPS6KB1 Hsap 69a0c46f00001110 FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) NCBITaxon:9606 gomodel:69a0c46f00001110/69a0c46f00001261 GO:0004674 protein serine/threonine kinase activity GO:0048026 positive regulation of mRNA splicing, via spliceosome false UniProtKB:P78362 SRPK2 Hsap 69a0c46f00001110 FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) NCBITaxon:9606 gomodel:69a0c46f00001110/69a0c46f00001336 GO:0004674 protein serine/threonine kinase activity GO:0000245 spliceosomal complex assembly GO:0005634 nucleus false UniProtKB:Q5T035 FAM120A2P Hsap 69a0c46f00001110 FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) NCBITaxon:9606 gomodel:69a0c46f00001110/69a0c46f00001352 GO:0030674 protein-macromolecule adaptor activity GO:0033120 positive regulation of RNA splicing GO:0000785 chromatin false UniProtKB:Q07955 SRSF1 Hsap 69a0c46f00001110 FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes (Human) NCBITaxon:9606 gomodel:69a0c46f00001110/69a0c46f00001370 GO:0003723 RNA binding GO:0033120 positive regulation of RNA splicing GO:0000785 chromatin false UniProtKB:Q06609 RAD51 Hsap 69a0c46f00002570 Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002570/69a0c46f00002571 GO:0000150 DNA strand exchange activity GO:0031297 replication fork processing GO:0035861 site of double-strand break false UniProtKB:P51587 BRCA2 Hsap 69a0c46f00002570 Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002570/69a0c46f00002580 GO:0030674 protein-macromolecule adaptor activity GO:0000730 DNA recombinase assembly GO:0035861 site of double-strand break false UniProtKB:P15374 UCHL3 Hsap 69a0c46f00002570 Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002570/69a0c46f00002592 GO:0004843 cysteine-type deubiquitinase activity GO:1905168 positive regulation of double-strand break repair via homologous recombination false UniProtKB:Q13315 ATM Hsap 69a0c46f00002570 Deubiquitination of RAD51 by UCHL3 promotes association between BRA2 and RAD51 and formation of nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002570/69a0c46f00002599 GO:0004674 protein serine/threonine kinase activity GO:1905168 positive regulation of double-strand break repair via homologous recombination false UniProtKB:Q06609 RAD51 Hsap 69a0c46f00002608 FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002608/69a0c46f00002609 GO:0000150 DNA strand exchange activity GO:0031297 replication fork processing GO:0035861 site of double-strand break false UniProtKB:Q6PIW4 FIGNL1 Hsap 69a0c46f00002608 FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002608/69a0c46f00002630 GO:0140776 protein-containing complex destabilizing activity GO:1990986 DNA recombinase disassembly GO:0000785 chromatin false UniProtKB:Q9NSG2 FIRRM Hsap 69a0c46f00002608 FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002608/69a0c46f00002642 GO:0003697 single-stranded DNA binding GO:2000042 negative regulation of double-strand break repair via homologous recombination GO:0090734 site of DNA damage false UniProtKB:P51587 BRCA2 Hsap 69a0c46f00002608 FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002608/69a0c46f00002650 GO:0030674 protein-macromolecule adaptor activity GO:0000724 double-strand break repair via homologous recombination GO:0035861 site of double-strand break false UniProtKB:P51587 BRCA2 Hsap 69a0c46f00002608 FIRRM and FIGNL1 inhibit formation of RAD51 nucleoprotein filaments during homologous recombination-mediated repair of DSBs (Human). NCBITaxon:9606 gomodel:69a0c46f00002608/69a0c46f00002660 GO:0140678 molecular function inhibitor activity GO:0000724 double-strand break repair via homologous recombination false UniProtKB:Q9NQV7 PRDM9 Hsap 69a0c46f00002668 Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). NCBITaxon:9606 gomodel:69a0c46f00002668/69a0c46f00002669 GO:0042800 histone H3K4 methyltransferase activity GO:0010845 positive regulation of reciprocal meiotic recombination GO:0005694 chromosome false UniProtKB:Q9Y5K1 SPO11 Hsap 69a0c46f00002668 Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). NCBITaxon:9606 gomodel:69a0c46f00002668/69a0c46f00002674 GO:0004520 DNA endonuclease activity GO:0042138 meiotic DNA double-strand break formation GO:0035861 site of double-strand break false UniProtKB:Q14565 DMC1 Hsap 69a0c46f00002668 Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). NCBITaxon:9606 gomodel:69a0c46f00002668/69a0c46f00002685 GO:0000150 DNA strand exchange activity GO:1990918 double-strand break repair involved in meiotic recombination GO:0005694 chromosome false UniProtKB:Q06609 RAD51 Hsap 69a0c46f00002668 Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). NCBITaxon:9606 gomodel:69a0c46f00002668/69a0c46f00002694 GO:0003697 single-stranded DNA binding GO:1990918 double-strand break repair involved in meiotic recombination GO:0035861 site of double-strand break false UniProtKB:P51587 BRCA2 Hsap 69a0c46f00002668 Formation of double-strand breaks (DSB) to initiate meiotic recombination (Human). NCBITaxon:9606 gomodel:69a0c46f00002668/69a0c46f00002705 GO:0030674 protein-macromolecule adaptor activity GO:0000730 DNA recombinase assembly false UniProtKB:Q5QGZ9 CLEC12A Hsap 69b3372b00001100 CLEC12a is an inhibitory receptor for uric acid crystals (Human) NCBITaxon:9606 gomodel:69b3372b00001100/69b3372b00001104 GO:0038187 pattern recognition receptor activity GO:0050728 negative regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:P29350 PTPN6 Hsap 69b3372b00001100 CLEC12a is an inhibitory receptor for uric acid crystals (Human) NCBITaxon:9606 gomodel:69b3372b00001100/69b3372b00001140 GO:0004725 protein tyrosine phosphatase activity GO:0050728 negative regulation of inflammatory response GO:0005886 plasma membrane false UniProtKB:P43405 SYK Hsap 69b3372b00001100 CLEC12a is an inhibitory receptor for uric acid crystals (Human) NCBITaxon:9606 gomodel:69b3372b00001100/69b3372b00001168 GO:0004713 protein tyrosine kinase activity GO:0050729 positive regulation of inflammatory response GO:0005737 cytoplasm false UniProtKB:Q2M3R5 SLC35G1 Hsap 69b3372b00001414 Intestinal absorption of citrate by the luminal and basolateral citrate transporters SLC13A2 and SLC35G1, respectively (Human). NCBITaxon:9606 gomodel:69b3372b00001414/69b3372b00001415 GO:0015137 citrate transmembrane transporter activity GO:0050892 intestinal absorption GO:0016323 basolateral plasma membrane false UniProtKB:Q13183 SLC13A2 Hsap 69b3372b00001414 Intestinal absorption of citrate by the luminal and basolateral citrate transporters SLC13A2 and SLC35G1, respectively (Human). NCBITaxon:9606 gomodel:69b3372b00001414/69b3372b00001431 GO:0015137 citrate transmembrane transporter activity GO:0050892 intestinal absorption GO:0016324 apical plasma membrane false UniProtKB:Q9H3F6 KCTD10 Hsap 69b3372b00001462 Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB (Human) NCBITaxon:9606 gomodel:69b3372b00001462/69b3372b00001463 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:1902523 positive regulation of protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 69b3372b00001462 Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB (Human) NCBITaxon:9606 gomodel:69b3372b00001462/69b3372b00001470 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 69b3372b00001462 Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB (Human) NCBITaxon:9606 gomodel:69b3372b00001462/69b3372b00001477 GO:0160072 ubiquitin ligase complex scaffold activity GO:1902523 positive regulation of protein K63-linked ubiquitination GO:0005737 cytoplasm false UniProtKB:P62745 RHOB Hsap 69b3372b00001462 Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB (Human) NCBITaxon:9606 gomodel:69b3372b00001462/69b3372b00001516 GO:0003924 GTPase activity GO:1903141 negative regulation of establishment of endothelial barrier GO:0005886 plasma membrane false UniProtKB:Q9H3F6 KCTD10 Hsap 69b3372b00001688 Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) NCBITaxon:9606 gomodel:69b3372b00001688/69b3372b00001689 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0045724 positive regulation of cilium assembly GO:0005737 cytoplasm false UniProtKB:P62877 RBX1 Hsap 69b3372b00001688 Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) NCBITaxon:9606 gomodel:69b3372b00001688/69b3372b00001696 GO:0061630 ubiquitin protein ligase activity GO:0045724 positive regulation of cilium assembly GO:0005737 cytoplasm false UniProtKB:Q13618 CUL3 Hsap 69b3372b00001688 Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) NCBITaxon:9606 gomodel:69b3372b00001688/69b3372b00001703 GO:0160072 ubiquitin ligase complex scaffold activity GO:0045724 positive regulation of cilium assembly GO:0005737 cytoplasm false UniProtKB:Q8IW35 CEP97 Hsap 69b3372b00001688 Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation (Human) NCBITaxon:9606 gomodel:69b3372b00001688/69b3372b00001734 GO:0030674 protein-macromolecule adaptor activity GO:1902018 negative regulation of cilium assembly GO:0005813 centrosome false UniProtKB:P31641 SLC6A6 Hsap 69b3372b00001929 SLC6A6 mediates taurine import in cell and mitochondrion (Human). NCBITaxon:9606 gomodel:69b3372b00001929/69b3372b00001930 GO:0005369 taurine:sodium symporter activity GO:2000773 negative regulation of cellular senescence GO:0005886 plasma membrane false UniProtKB:P17612 PRKACA Hsap 69b3372b00001929 SLC6A6 mediates taurine import in cell and mitochondrion (Human). NCBITaxon:9606 gomodel:69b3372b00001929/69b3372b00001953 GO:0004691 cAMP-dependent protein kinase activity GO:1903078 positive regulation of protein localization to plasma membrane GO:0005737 cytoplasm false UniProtKB:P31641 SLC6A6 Hsap 69b3372b00001929 SLC6A6 mediates taurine import in cell and mitochondrion (Human). NCBITaxon:9606 gomodel:69b3372b00001929/69b3372b00002108 GO:0005369 taurine:sodium symporter activity GO:0070131 positive regulation of mitochondrial translation GO:0005743 mitochondrial inner membrane false UniProtKB:Q00987 MDM2 Hsap 69b3372b00001963 MDM2-UBE4B cooperation to ubiquitinate P53 (Human) NCBITaxon:9606 gomodel:69b3372b00001963/69b3372b00001964 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:O95155 UBE4B Hsap 69b3372b00001963 MDM2-UBE4B cooperation to ubiquitinate P53 (Human) NCBITaxon:9606 gomodel:69b3372b00001963/69b3372b00001975 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P04637 TP53 Hsap 69b3372b00001963 MDM2-UBE4B cooperation to ubiquitinate P53 (Human) NCBITaxon:9606 gomodel:69b3372b00001963/69b3372b00001985 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0000785 chromatin false UniProtKB:Q07812 BAX Hsap 69b3372b00001963 MDM2-UBE4B cooperation to ubiquitinate P53 (Human) NCBITaxon:9606 gomodel:69b3372b00001963/69b3372b00001995 GO:0015267 channel activity GO:0097193 intrinsic apoptotic signaling pathway GO:0005741 mitochondrial outer membrane false UniProtKB:Q9HB90 RRAGC Hsap 69b3372b00002031 Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) NCBITaxon:9606 gomodel:69b3372b00002031/69b3372b00002032 GO:0019003 GDP binding GO:1904263 positive regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:O75140 DEPDC5 Hsap 69b3372b00002031 Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) NCBITaxon:9606 gomodel:69b3372b00002031/69b3372b00002043 GO:0031267 small GTPase binding GO:1904262 negative regulation of TORC1 signaling GO:0005765 lysosomal membrane false UniProtKB:Q53GT1 KLHL22 Hsap 69b3372b00002031 Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) NCBITaxon:9606 gomodel:69b3372b00002031/69b3372b00002057 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0005764 lysosome false UniProtKB:P62877 RBX1 Hsap 69b3372b00002031 Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) NCBITaxon:9606 gomodel:69b3372b00002031/69b3372b00002076 GO:0031625 ubiquitin protein ligase binding GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:O95155 UBE4B Hsap 69b3372b00002031 Fine-tuning of mTOR signaling by the UBE4B-KLHL22 E3 ubiquitin ligase (Human) NCBITaxon:9606 gomodel:69b3372b00002031/69b3372b00002098 GO:0061630 ubiquitin protein ligase activity GO:0006511 ubiquitin-dependent protein catabolic process GO:0005737 cytoplasm false UniProtKB:P23945 FSHR Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/69b3372b00003349 GO:0004963 follicle-stimulating hormone receptor activity GO:0001541 ovarian follicle development GO:0005886 plasma membrane false GO:0016914 follicle-stimulating hormone complex 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/69b3372b00003379 GO:0016913 follicle-stimulating hormone activity GO:0005576 extracellular region false UniProtKB:P63092 GNAS Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/69c59f8a00001719 GO:0003925 G protein activity GO:0001541 ovarian follicle development GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P17612 PRKACA Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/6a2b236300000864 GO:0004691 cAMP-dependent protein kinase activity GO:0001541 ovarian follicle development GO:0005634 nucleus false UniProtKB:P16220 CREB1 Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/6a2b236300001087 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001541 ovarian follicle development GO:0005634 nucleus false UniProtKB:P11511 CYP19A1 Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/6a2b236300001173 GO:0070330 aromatase activity GO:0001541 ovarian follicle development GO:0005789 endoplasmic reticulum membrane true sex_steroid_biosynthesis UniProtKB:O43823 AKAP8 Hsap 69b3372b00003343 FSH delivery to granulosa cells promotes follicle development (Human) NCBITaxon:9606 gomodel:69b3372b00003343/6a2b236300001185 GO:0140777 protein-containing complex stabilizing activity GO:0001541 ovarian follicle development GO:0005634 nucleus false UniProtKB:Q9BXJ0 C1QTNF5 Hsap 69b3372b00003740 C1QTNF5 antagonizes ADIPOR1 activity in retinal pigment epithelium and is involved in the regulation of lipid metabolism (Human) NCBITaxon:9606 gomodel:69b3372b00003740/69b3372b00003745 GO:0030547 signaling receptor inhibitor activity GO:0050995 negative regulation of lipid catabolic process GO:0005576 extracellular region false UniProtKB:Q96A54 ADIPOR1 Hsap 69b3372b00003740 C1QTNF5 antagonizes ADIPOR1 activity in retinal pigment epithelium and is involved in the regulation of lipid metabolism (Human) NCBITaxon:9606 gomodel:69b3372b00003740/69b3372b00003756 GO:0097003 adipokinetic hormone receptor activity GO:0033211 adiponectin-activated signaling pathway GO:0005886 plasma membrane false UniProtKB:P54646 PRKAA2 Hsap 69b3372b00003740 C1QTNF5 antagonizes ADIPOR1 activity in retinal pigment epithelium and is involved in the regulation of lipid metabolism (Human) NCBITaxon:9606 gomodel:69b3372b00003740/69b3372b00003778 GO:0004679 AMP-activated protein kinase activity GO:0033211 adiponectin-activated signaling pathway GO:0005737 cytoplasm false UniProtKB:Q15848 ADIPOQ Hsap 69b3372b00003740 C1QTNF5 antagonizes ADIPOR1 activity in retinal pigment epithelium and is involved in the regulation of lipid metabolism (Human) NCBITaxon:9606 gomodel:69b3372b00003740/69c59f8a00000868 GO:0005179 hormone activity GO:0033211 adiponectin-activated signaling pathway GO:0005576 extracellular region false UniProtKB:P21728 DRD1 Hsap 69c59f8a00000043 "DRD1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00000043/69c59f8a00000044 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0045211 postsynaptic membrane false UniProtKB:P63092 GNAS Hsap 69c59f8a00000043 "DRD1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00000043/69c59f8a00000046 GO:0003925 G protein activity GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00000043 "DRD1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00000043/69c59f8a00000048 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P21728 DRD1 Hsap 69c59f8a00000079 Negative regulation of DRD1-mediated signaling following phosphorylation by PKC (Human). NCBITaxon:9606 gomodel:69c59f8a00000079/69c59f8a00000080 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0045211 postsynaptic membrane false UniProtKB:P63092 GNAS Hsap 69c59f8a00000079 Negative regulation of DRD1-mediated signaling following phosphorylation by PKC (Human). NCBITaxon:9606 gomodel:69c59f8a00000079/69c59f8a00000082 GO:0003925 G protein activity GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00000079 Negative regulation of DRD1-mediated signaling following phosphorylation by PKC (Human). NCBITaxon:9606 gomodel:69c59f8a00000079/69c59f8a00000084 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P17252 PRKCA Hsap 69c59f8a00000079 Negative regulation of DRD1-mediated signaling following phosphorylation by PKC (Human). NCBITaxon:9606 gomodel:69c59f8a00000079/69c59f8a00000109 GO:0004698 calcium,diacylglycerol-dependent serine/threonine kinase activity GO:0060160 negative regulation of dopamine receptor signaling pathway false UniProtKB:P07101 TH Hsap 69c59f8a00000117 Dopamine biosynthesis (Human). NCBITaxon:9606 gomodel:69c59f8a00000117/69c59f8a00000118 GO:0004511 tyrosine 3-monooxygenase activity GO:0042416 dopamine biosynthetic process false UniProtKB:P20711 DDC Hsap 69c59f8a00000117 Dopamine biosynthesis (Human). NCBITaxon:9606 gomodel:69c59f8a00000117/69c59f8a00000124 GO:0036468 L-dopa decarboxylase activity GO:0042416 dopamine biosynthetic process false UniProtKB:Q92847 GHSR Hsap 69c59f8a00000139 DRD1 forms a heteromer with GHSR in hippocampal neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00000139/69c59f8a00000140 GO:0015026 coreceptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 69c59f8a00000139 DRD1 forms a heteromer with GHSR in hippocampal neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00000139/69c59f8a00000147 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 69c59f8a00000139 DRD1 forms a heteromer with GHSR in hippocampal neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00000139/69c59f8a00000154 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P21728 DRD1 Hsap 69c59f8a00000139 DRD1 forms a heteromer with GHSR in hippocampal neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00000139/69c59f8a00000181 GO:0004952 dopamine neurotransmitter receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P04637 TP53 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000220 GO:0003700 DNA-binding transcription factor activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:P38936 CDKN1A Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000227 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0000077 DNA damage checkpoint signaling false UniProtKB:Q13547 HDAC1 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000232 GO:0004407 histone deacetylase activity GO:0060633 negative regulation of transcription initiation by RNA polymerase II false UniProtKB:O15062 ZBTB5 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000234 GO:0003700 DNA-binding transcription factor activity GO:0060633 negative regulation of transcription initiation by RNA polymerase II false UniProtKB:Q09472 EP300 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000237 GO:0004402 histone acetyltransferase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:Q09472 EP300 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000238 GO:0061733 protein-lysine-acetyltransferase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:Q96AE4 FUBP1 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000304 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0060633 negative regulation of transcription initiation by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q9UPT9 USP22 Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000312 GO:0101005 deubiquitinase activity GO:0060633 negative regulation of transcription initiation by RNA polymerase II GO:0005634 nucleus false UniProtKB:Q92831 KAT2B Hsap 69c59f8a00000219 CDKN1A/WAF1/CIP1/p21 induction via PCAF-SAGA NCBITaxon:9606 gomodel:69c59f8a00000219/69c59f8a00000321 GO:0061733 protein-lysine-acetyltransferase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II GO:0000785 chromatin false UniProtKB:P46937 YAP1 Hsap 69c59f8a00001359 KRT15 negative regulation of Hippo signaling via YAP1_OFF state_Human NCBITaxon:9606 gomodel:69c59f8a00001359/69c59f8a00001360 GO:0003713 transcription coactivator activity GO:0010838 positive regulation of keratinocyte proliferation GO:0005634 nucleus false UniProtKB:P19012 KRT15 Hsap 69c59f8a00001359 KRT15 negative regulation of Hippo signaling via YAP1_OFF state_Human NCBITaxon:9606 gomodel:69c59f8a00001359/69c59f8a00001363 GO:0005200 structural constituent of cytoskeleton GO:0030857 negative regulation of epithelial cell differentiation GO:0045095 keratin filament false UniProtKB:P31947 SFN Hsap 69c59f8a00001359 KRT15 negative regulation of Hippo signaling via YAP1_OFF state_Human NCBITaxon:9606 gomodel:69c59f8a00001359/69c59f8a00001365 GO:0140311 protein sequestering activity GO:0035332 positive regulation of hippo signaling GO:0005737 cytoplasm false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00001396 In the central nervous system, DRD2 signaling is mainly mediated via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69c59f8a00001396/69c59f8a00001397 GO:0004016 adenylate cyclase activity GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway false UniProtKB:P09471 GNAO1 Hsap 69c59f8a00001396 In the central nervous system, DRD2 signaling is mainly mediated via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69c59f8a00001396/69c59f8a00001398 GO:0003925 G protein activity GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P14416 DRD2 Hsap 69c59f8a00001396 In the central nervous system, DRD2 signaling is mainly mediated via G-alpha-o (inhibitory), inhibiting adenylate cyclase (Human). NCBITaxon:9606 gomodel:69c59f8a00001396/69c59f8a00001413 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0045211 postsynaptic membrane false UniProtKB:P14416 DRD2 Hsap 69c59f8a00001439 DRD2-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00001439/69c59f8a00001440 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0045211 postsynaptic membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00001439 DRD2-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00001439/69c59f8a00001441 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69c59f8a00001439 DRD2-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00001439/69c59f8a00001442 GO:0003925 G protein activity GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q92847 GHSR Hsap 69c59f8a00001474 DRD2 forms a heteromer with GHSR in spinal cord neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00001474/69c59f8a00001475 GO:0015026 coreceptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P50148 GNAQ Hsap 69c59f8a00001474 DRD2 forms a heteromer with GHSR in spinal cord neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00001474/69c59f8a00001482 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 69c59f8a00001474 DRD2 forms a heteromer with GHSR in spinal cord neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00001474/69c59f8a00001489 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P14416 DRD2 Hsap 69c59f8a00001474 DRD2 forms a heteromer with GHSR in spinal cord neurons, promoting G-alpha-q/11 (phospholipase c-activating, IP3, DAG)-mediated signaling (Human). NCBITaxon:9606 gomodel:69c59f8a00001474/69c59f8a00001506 GO:0004952 dopamine neurotransmitter receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P46937 YAP1 Hsap 69c59f8a00002811 KRT14 positive regulation of Hippo signaling via YAP1_ON state_Human NCBITaxon:9606 gomodel:69c59f8a00002811/69c59f8a00002812 GO:0003713 transcription coactivator activity GO:0010838 positive regulation of keratinocyte proliferation GO:0005634 nucleus false UniProtKB:P02533 KRT14 Hsap 69c59f8a00002811 KRT14 positive regulation of Hippo signaling via YAP1_ON state_Human NCBITaxon:9606 gomodel:69c59f8a00002811/69c59f8a00002815 GO:0005200 structural constituent of cytoskeleton GO:0045618 positive regulation of keratinocyte differentiation GO:0045095 keratin filament false UniProtKB:P31947 SFN Hsap 69c59f8a00002811 KRT14 positive regulation of Hippo signaling via YAP1_ON state_Human NCBITaxon:9606 gomodel:69c59f8a00002811/69c59f8a00002817 GO:0140311 protein sequestering activity GO:0035332 positive regulation of hippo signaling GO:0005737 cytoplasm false UniProtKB:P35462 DRD3 Hsap 69c59f8a00002981 DRD3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00002981/69c59f8a00002982 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00002981 DRD3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00002981/69c59f8a00002983 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69c59f8a00002981 DRD3-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00002981/69c59f8a00002984 GO:0003925 G protein activity GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P21917 DRD4 Hsap 69c59f8a00003111 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00003111/69c59f8a00003112 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00003111 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00003111/69c59f8a00003113 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69c59f8a00003111 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by dopamine (Human). NCBITaxon:9606 gomodel:69c59f8a00003111/69c59f8a00003114 GO:0003925 G protein activity GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P21917 DRD4 Hsap 69c59f8a00003141 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by adrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003141/69c59f8a00003142 GO:0004935 adrenergic receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00003141 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by adrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003141/69c59f8a00003143 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69c59f8a00003141 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by adrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003141/69c59f8a00003144 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P21917 DRD4 Hsap 69c59f8a00003173 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by noradrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003173/69c59f8a00003174 GO:0004935 adrenergic receptor activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00003173 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by noradrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003173/69c59f8a00003175 GO:0004016 adenylate cyclase activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway false UniProtKB:P63096 GNAI1 Hsap 69c59f8a00003173 DRD4-mediated signaling via G-alpha-i (inhibitory), inhibiting adenylate cyclase) following activation by noradrenaline (Human). NCBITaxon:9606 gomodel:69c59f8a00003173/69c59f8a00003176 GO:0003925 G protein activity GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P21918 DRD5 Hsap 69c59f8a00003487 "DRD5-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00003487/69c59f8a00003488 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69c59f8a00003487 "DRD5-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00003487/69c59f8a00003490 GO:0003925 G protein activity GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69c59f8a00003487 "DRD5-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) following activation by dopamine (Human)." NCBITaxon:9606 gomodel:69c59f8a00003487/69c59f8a00003492 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:P04637 TP53 Hsap 69d8496c00000318 CDKN1A/WAF1/CIP1/p21 induction via HIPK2 NCBITaxon:9606 gomodel:69d8496c00000318/69d8496c00000319 GO:0003700 DNA-binding transcription factor activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:P38936 CDKN1A Hsap 69d8496c00000318 CDKN1A/WAF1/CIP1/p21 induction via HIPK2 NCBITaxon:9606 gomodel:69d8496c00000318/69d8496c00000324 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0000077 DNA damage checkpoint signaling false UniProtKB:Q09472 EP300 Hsap 69d8496c00000318 CDKN1A/WAF1/CIP1/p21 induction via HIPK2 NCBITaxon:9606 gomodel:69d8496c00000318/69d8496c00000332 GO:0004402 histone acetyltransferase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II false UniProtKB:Q92831 KAT2B Hsap 69d8496c00000318 CDKN1A/WAF1/CIP1/p21 induction via HIPK2 NCBITaxon:9606 gomodel:69d8496c00000318/69d8496c00000390 GO:0061733 protein-lysine-acetyltransferase activity GO:0060261 positive regulation of transcription initiation by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q9H2X6 HIPK2 Hsap 69d8496c00000318 CDKN1A/WAF1/CIP1/p21 induction via HIPK2 NCBITaxon:9606 gomodel:69d8496c00000318/69d8496c00000409 GO:0003674 molecular_function GO:0000077 DNA damage checkpoint signaling false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00000667 Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) NCBITaxon:9606 gomodel:69d8496c00000667/69d8496c00000668 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000667 Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) NCBITaxon:9606 gomodel:69d8496c00000667/69d8496c00000699 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000667 Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) NCBITaxon:9606 gomodel:69d8496c00000667/69d8496c00000708 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000667 Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) NCBITaxon:9606 gomodel:69d8496c00000667/69d8496c00000717 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:O14744 PRMT5 Hsap 69d8496c00000667 Inhibition of cGAS-STING signaling following CGAS methylation by PRMT5 (Human) NCBITaxon:9606 gomodel:69d8496c00000667/69d8496c00000731 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000740 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000751 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000760 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000769 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q92830 KAT2A Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000791 GO:0061733 protein-lysine-acetyltransferase activity GO:0072659 protein localization to plasma membrane GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O00160 MYO1F Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000802 GO:0030674 protein-macromolecule adaptor activity GO:0072659 protein localization to plasma membrane GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:P43405 SYK Hsap 69d8496c00000739 MYO1F promotes CGAS localization to the plasma membrane (Human) NCBITaxon:9606 gomodel:69d8496c00000739/69d8496c00000817 GO:0004713 protein tyrosine kinase activity GO:0141111 positive regulation of cGAS/STING signaling pathway false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00000831 STING1 is activated by c-di-GMP, a second messenger produced by bacteria, activating the antibacterial innate immune response (Human) NCBITaxon:9606 gomodel:69d8496c00000831/69d8496c00000832 GO:0035591 signaling adaptor activity GO:0140367 antibacterial innate immune response GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q9UHD2 TBK1 Hsap 69d8496c00000831 STING1 is activated by c-di-GMP, a second messenger produced by bacteria, activating the antibacterial innate immune response (Human) NCBITaxon:9606 gomodel:69d8496c00000831/69d8496c00000841 GO:0004674 protein serine/threonine kinase activity GO:0002218 activation of innate immune response GO:0005829 cytosol false UniProtKB:Q9UHD2 TBK1 Hsap 69d8496c00000831 STING1 is activated by c-di-GMP, a second messenger produced by bacteria, activating the antibacterial innate immune response (Human) NCBITaxon:9606 gomodel:69d8496c00000831/69d8496c00000850 GO:0004674 protein serine/threonine kinase activity GO:0032481 positive regulation of type I interferon production GO:0005829 cytosol false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00000973 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00000984 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00000993 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00001002 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9UII4 HERC5 Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00001024 GO:0061662 ISG15 ligase activity GO:0141111 positive regulation of cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9UII4 HERC5 Hsap 69d8496c00000972 Activation of cGAS-STING signaling following ISGylation of CGAS and STING1 by HERC5 (Human). NCBITaxon:9606 gomodel:69d8496c00000972/69d8496c00001044 GO:0061662 ISG15 ligase activity GO:0141111 positive regulation of cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00001117 Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). NCBITaxon:9606 gomodel:69d8496c00001117/69d8496c00001118 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001117 Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). NCBITaxon:9606 gomodel:69d8496c00001117/69d8496c00001129 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001117 Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). NCBITaxon:9606 gomodel:69d8496c00001117/69d8496c00001138 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001117 Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). NCBITaxon:9606 gomodel:69d8496c00001117/69d8496c00001147 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q9UMW8 USP18 Hsap 69d8496c00001117 Inhibition of cGAS-STING signaling following DeISGylation of CGAS by USP18 (Human). NCBITaxon:9606 gomodel:69d8496c00001117/69d8496c00001161 GO:0019785 ISG15-specific peptidase activity GO:0160049 negative regulation of cGAS/STING signaling pathway false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00001193 Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). NCBITaxon:9606 gomodel:69d8496c00001193/69d8496c00001194 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001193 Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). NCBITaxon:9606 gomodel:69d8496c00001193/69d8496c00001205 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001193 Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). NCBITaxon:9606 gomodel:69d8496c00001193/69d8496c00001214 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001193 Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). NCBITaxon:9606 gomodel:69d8496c00001193/69d8496c00001223 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:P0DTD1-PRO_0000449621 nsp3 Scov2 69d8496c00001193 Inhibition of cGAS-STING signaling following DeISGylation of STING1 by SARS-CoV-2 viral protein NSP3 (Human). NCBITaxon:9606 gomodel:69d8496c00001193/69d8496c00001237 GO:0019785 ISG15-specific peptidase activity GO:0141074 symbiont-mediated suppression of host cGAS-STING signal transduction false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00001257 Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) NCBITaxon:9606 gomodel:69d8496c00001257/69d8496c00001258 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001257 Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) NCBITaxon:9606 gomodel:69d8496c00001257/69d8496c00001269 GO:0140693 molecular condensate scaffold activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001257 Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) NCBITaxon:9606 gomodel:69d8496c00001257/69d8496c00001278 GO:0061501 2',3'-cyclic GMP-AMP synthase activity GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q8N884 CGAS Hsap 69d8496c00001257 Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) NCBITaxon:9606 gomodel:69d8496c00001257/69d8496c00001287 GO:0003690 double-stranded DNA binding GO:0140896 cGAS/STING signaling pathway GO:0005829 cytosol false UniProtKB:Q86WT6 TRIM69 Hsap 69d8496c00001257 Activation of cGAS-STING signaling following STING1 ubiquitination by TRIM69 (Human) NCBITaxon:9606 gomodel:69d8496c00001257/69d8496c00001309 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q9NYJ8 TAB2 Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001462 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001470 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001481 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001489 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001500 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001508 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9NQC7 CYLD Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001539 GO:0061578 K63-linked deubiquitinase activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction false UniProtKB:Q14164 IKBKE Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001546 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q14164 IKBKE Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001556 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q14164 IKBKE Hsap 69d8496c00001461 IKBKE/IKKepsilon promote NF-kappa-B signaling by mediating phosphorylation of different proteins of NF-kappa-B signaling , such as RELA, CYLD and NFKBIA (Human). NCBITaxon:9606 gomodel:69d8496c00001461/69d8496c00001566 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001577 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001585 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001596 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001604 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001615 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001623 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9Y4K3 TRAF6 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001634 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z6Z7 HUWE1 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001641 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001661 GO:0035591 signaling adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0036020 endolysosome membrane false UniProtKB:O75807 PPP1R15A Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001679 GO:0140870 RNA polymerase inhibitor activity GO:0044828 host-mediated suppression of viral genome replication false UniProtKB:Q14164 IKBKE Hsap 69d8496c00001576 STING1 promotes NF-kappa-B signaling in response to virus infection (Human). NCBITaxon:9606 gomodel:69d8496c00001576/69d8496c00001687 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:Q9NYJ8 TAB2 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001702 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001710 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001721 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001729 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001740 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001748 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9Y4K3 TRAF6 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001759 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z6Z7 HUWE1 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001766 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001779 GO:0035591 signaling adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0036020 endolysosome membrane false UniProtKB:O75807 PPP1R15A Hsap 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001797 GO:0140870 RNA polymerase inhibitor activity GO:0044828 host-mediated suppression of viral genome replication false UniProtKB:P03485 M NCBITaxon:211044 69d8496c00001701 Influenza virus M protein inhibits STING1 ability to activate NF-kappa-B signaling (Influenza virus and Human). NCBITaxon:9606 gomodel:69d8496c00001701/69d8496c00001819 GO:0140678 molecular function inhibitor activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade false UniProtKB:Q8N6H7 ARFGAP2 Hsap 69d8496c00002213 ARFGAP2 has GTPase activating activity for ARF1 during COPI vesicle formation (Human). NCBITaxon:9606 gomodel:69d8496c00002213/69d8496c00002214 GO:0005096 GTPase activator activity GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0000139 Golgi membrane false UniProtKB:P84077 ARF1 Hsap 69d8496c00002213 ARFGAP2 has GTPase activating activity for ARF1 during COPI vesicle formation (Human). NCBITaxon:9606 gomodel:69d8496c00002213/69d8496c00002223 GO:0003925 G protein activity GO:0035964 COPI-coated vesicle budding GO:0000139 Golgi membrane false GO:0030126 COPI vesicle coat 69d8496c00002213 ARFGAP2 has GTPase activating activity for ARF1 during COPI vesicle formation (Human). NCBITaxon:9606 gomodel:69d8496c00002213/69d8496c00002232 GO:0140597 protein carrier activity GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0005789 endoplasmic reticulum membrane false UniProtKB:Q6P3S6 FBXO42 Hsap 69d8496c00003152 FBXO42-mediated degradation of p53 via CUL1/RBX1 (Human) NCBITaxon:9606 gomodel:69d8496c00003152/69d8496c00003173 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 69d8496c00003152 FBXO42-mediated degradation of p53 via CUL1/RBX1 (Human) NCBITaxon:9606 gomodel:69d8496c00003152/69d8496c00003180 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q13616 CUL1 Hsap 69d8496c00003152 FBXO42-mediated degradation of p53 via CUL1/RBX1 (Human) NCBITaxon:9606 gomodel:69d8496c00003152/69d8496c00003190 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P04637 TP53 Hsap 69d8496c00003152 FBXO42-mediated degradation of p53 via CUL1/RBX1 (Human) NCBITaxon:9606 gomodel:69d8496c00003152/69d8496c00003296 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0006974 DNA damage response GO:0005634 nucleus false UniProtKB:Q6P3S6 FBXO42 Hsap 69d8496c00003234 FBXO42-mediated degradation of PPP4C via CUL1 (Human) NCBITaxon:9606 gomodel:69d8496c00003234/69d8496c00003235 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 69d8496c00003234 FBXO42-mediated degradation of PPP4C via CUL1 (Human) NCBITaxon:9606 gomodel:69d8496c00003234/69d8496c00003242 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q13616 CUL1 Hsap 69d8496c00003234 FBXO42-mediated degradation of PPP4C via CUL1 (Human) NCBITaxon:9606 gomodel:69d8496c00003234/69d8496c00003250 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P60510 PPP4C Hsap 69d8496c00003234 FBXO42-mediated degradation of PPP4C via CUL1 (Human) NCBITaxon:9606 gomodel:69d8496c00003234/69ea894900000659 GO:0004722 protein serine/threonine phosphatase activity GO:0010569 regulation of double-strand break repair via homologous recombination GO:0000785 chromatin false UniProtKB:Q9NYJ8 TAB2 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003494 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003502 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003513 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003521 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003532 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003540 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9Y4K3 TRAF6 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003551 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z6Z7 HUWE1 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003558 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003571 GO:0035591 signaling adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0036020 endolysosome membrane false UniProtKB:P18099 vpx NCBITaxon:11714 69d8496c00003493 HIV-2 virus Vpx protein inhibits STING1 ability to activate NF-kappa-B signaling (HIV-2 and Human). NCBITaxon:9606 gomodel:69d8496c00003493/69d8496c00003597 GO:0140678 molecular function inhibitor activity GO:0085034 symbiont-mediated suppression of host NF-kappaB cascade false UniProtKB:Q9NYJ8 TAB2 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004473 GO:0070530 K63-linked polyubiquitin modification-dependent protein binding GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O43318 MAP3K7 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004481 GO:0004674 protein serine/threonine kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction false UniProtKB:O14920 IKBKB Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004492 GO:0008384 IkappaB kinase activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P25963 NFKBIA Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004500 GO:0140311 protein sequestering activity GO:0043124 negative regulation of canonical NF-kappaB signal transduction GO:0005737 cytoplasm false UniProtKB:P19838 NFKB1 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004511 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q04206 RELA Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004519 GO:0003700 DNA-binding transcription factor activity GO:0007249 canonical NF-kappaB signal transduction GO:0000785 chromatin false UniProtKB:Q9Y4K3 TRAF6 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004530 GO:0034450 ubiquitin-ubiquitin ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q7Z6Z7 HUWE1 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004537 GO:0061630 ubiquitin protein ligase activity GO:0070936 protein K48-linked ubiquitination false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004550 GO:0035591 signaling adaptor activity GO:0043123 positive regulation of canonical NF-kappaB signal transduction GO:0036020 endolysosome membrane false UniProtKB:Q9HAT8 PELI2 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004575 GO:0061630 ubiquitin protein ligase activity GO:0070534 protein K63-linked ubiquitination false UniProtKB:Q9UHD2 TBK1 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004586 GO:0004674 protein serine/threonine kinase activity GO:0002218 activation of innate immune response GO:0005829 cytosol false UniProtKB:Q86WV6 STING1 Hsap 69d8496c00004472 PELI2 mediates ubiquitination of TBK1, inhibiting cGAS-STING signaling while promoting STING1 ability to activate NF-kappa-B signaling (Human). NCBITaxon:9606 gomodel:69d8496c00004472/69d8496c00004595 GO:0035591 signaling adaptor activity GO:0140896 cGAS/STING signaling pathway GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane false UniProtKB:O95222 OR6A2 Hsap 69d8496c00005445 "OR6A2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by octanal (Human)." NCBITaxon:9606 gomodel:69d8496c00005445/69d8496c00005446 GO:0038022 G protein-coupled olfactory receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 69d8496c00005445 "OR6A2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by octanal (Human)." NCBITaxon:9606 gomodel:69d8496c00005445/69d8496c00005448 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 69d8496c00005445 "OR6A2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by octanal (Human)." NCBITaxon:9606 gomodel:69d8496c00005445/69d8496c00005450 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:O95222 OR6A2 Hsap 69d8496c00005490 "In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human)." NCBITaxon:9606 gomodel:69d8496c00005490/69d8496c00005491 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69d8496c00005490 "In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human)." NCBITaxon:9606 gomodel:69d8496c00005490/69d8496c00005493 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69d8496c00005490 "In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human)." NCBITaxon:9606 gomodel:69d8496c00005490/69d8496c00005495 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false UniProtKB:Q96P20 NLRP3 Hsap 69d8496c00005490 "In macrophages, octanal activates OR6A2-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase), promoting NLRP3 inflammasome assembly (Human)." NCBITaxon:9606 gomodel:69d8496c00005490/69d8496c00005530 GO:0035591 signaling adaptor activity GO:0044546 NLRP3 inflammasome complex assembly GO:0005815 microtubule organizing center false UniProtKB:P09874 PARP1 Hsap 69ea894900000181 PARP1 stabilizes AFF1 involved in transcriptional restart after DNA damage (Human) NCBITaxon:9606 gomodel:69ea894900000181/69ea894900000182 GO:0140805 NAD+-protein-serine ADP-ribosyltransferase activity GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0090734 site of DNA damage false UniProtKB:P51825 AFF1 Hsap 69ea894900000181 PARP1 stabilizes AFF1 involved in transcriptional restart after DNA damage (Human) NCBITaxon:9606 gomodel:69ea894900000181/69ea894900000245 GO:0003711 transcription elongation factor activity GO:0032786 positive regulation of DNA-templated transcription, elongation GO:0090734 site of DNA damage false UniProtKB:Q8IUQ4 SIAH1 Hsap 69ea894900000181 PARP1 stabilizes AFF1 involved in transcriptional restart after DNA damage (Human) NCBITaxon:9606 gomodel:69ea894900000181/69ea894900000251 GO:0061630 ubiquitin protein ligase activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process false UniProtKB:Q9H255 OR51E2 Hsap 69ea894900000425 "OR51E2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by propionate (Human)." NCBITaxon:9606 gomodel:69ea894900000425/69ea894900000426 GO:0038022 G protein-coupled olfactory receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 69ea894900000425 "OR51E2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by propionate (Human)." NCBITaxon:9606 gomodel:69ea894900000425/69ea894900000428 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 69ea894900000425 "OR51E2-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by propionate (Human)." NCBITaxon:9606 gomodel:69ea894900000425/69ea894900000430 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q01970 PLCB3 Hsap 69ea894900000468 Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69ea894900000468/69ea894900000469 GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO:0007208 phospholipase C-activating serotonin receptor signaling pathway GO:0005737 cytoplasm false UniProtKB:P50148 GNAQ Hsap 69ea894900000468 Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69ea894900000468/69ea894900000480 GO:0003925 G protein activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:Q96P68 OXGR1 Hsap 69ea894900000468 Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69ea894900000468/69ea894900000488 GO:0004930 G protein-coupled receptor activity GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q15746-3 MYLK Hsap 69ea894900000468 Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69ea894900000468/69ea894900000500 GO:0004687 myosin light chain kinase activity GO:1904695 positive regulation of vascular associated smooth muscle contraction GO:0005737 cytoplasm false UniProtKB:P24844 MYL9 Hsap 69ea894900000468 Activation of OXGR1 by 2-oxoglutarate promotes vascular smooth muscle cell contraction via G-alpha-q (phospholipase c-activating, IP3, DAG) signaling (Human). NCBITaxon:9606 gomodel:69ea894900000468/69ea894900000509 GO:0005200 structural constituent of cytoskeleton GO:0014829 vascular associated smooth muscle contraction GO:0005856 cytoskeleton false UniProtKB:Q9UGF6 OR5V1 Hsap 69ea894900000521 "OR5V1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate (Human)." NCBITaxon:9606 gomodel:69ea894900000521/69ea894900000522 GO:0038022 G protein-coupled olfactory receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 69ea894900000521 "OR5V1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate (Human)." NCBITaxon:9606 gomodel:69ea894900000521/69ea894900000524 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 69ea894900000521 "OR5V1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by methyl (9R,10E,12E)-9-methoxyoctadeca-10,12-dienoate (Human)." NCBITaxon:9606 gomodel:69ea894900000521/69ea894900000526 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:Q9UGF6 OR5V1 Hsap 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000565 GO:0004930 G protein-coupled receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P63092 GNAS Hsap 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000567 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O43306 ADCY6 Hsap 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000569 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway false GO:0005952 cAMP-dependent protein kinase complex 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000616 GO:0004691 cAMP-dependent protein kinase activity GO:0001678 intracellular glucose homeostasis false UniProtKB:P15336 ATF2 Hsap 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000623 GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001678 intracellular glucose homeostasis GO:0005634 nucleus false UniProtKB:P50416 CPT1A Hsap 69ea894900000564 "In liver, 12(S)-HEPE activates OR5V1-mediated signaling via G-alpha-s (""stimulatory"", activating adenylate cyclase) and regulating glucose homeostasis (Human)." NCBITaxon:9606 gomodel:69ea894900000564/69ea894900000636 GO:0004095 carnitine O-palmitoyltransferase activity GO:0006635 fatty acid beta-oxidation true carnitine_shuttle UniProtKB:Q6P3S6 FBXO42 Hsap 69ea894900000668 FBXO42-mediated degradation of PPP2C via CUL1 (Human) NCBITaxon:9606 gomodel:69ea894900000668/69ea894900000669 GO:1990756 ubiquitin-like ligase-substrate adaptor activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P62877 RBX1 Hsap 69ea894900000668 FBXO42-mediated degradation of PPP2C via CUL1 (Human) NCBITaxon:9606 gomodel:69ea894900000668/69ea894900000676 GO:0061630 ubiquitin protein ligase activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:Q13616 CUL1 Hsap 69ea894900000668 FBXO42-mediated degradation of PPP2C via CUL1 (Human) NCBITaxon:9606 gomodel:69ea894900000668/69ea894900000684 GO:0160072 ubiquitin ligase complex scaffold activity GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0005634 nucleus false UniProtKB:P67775 PPP2CA Hsap 69ea894900000668 FBXO42-mediated degradation of PPP2C via CUL1 (Human) NCBITaxon:9606 gomodel:69ea894900000668/69ea894900000707 GO:0004722 protein serine/threonine phosphatase activity GO:0034243 regulation of transcription elongation by RNA polymerase II GO:0000785 chromatin false UniProtKB:Q16204 CCDC6 Hsap 69ea894900000668 FBXO42-mediated degradation of PPP2C via CUL1 (Human) NCBITaxon:9606 gomodel:69ea894900000668/69ea894900000715 GO:0140378 protein complex scaffold activity GO:0062027 positive regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process false UniProtKB:Q9P1Q5 OR1A1 Hsap 69ea894900001010 "OR1A1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by 3- methyl-2,4-nonanedione(Human)." NCBITaxon:9606 gomodel:69ea894900001010/69ea894900001011 GO:0038022 G protein-coupled olfactory receptor activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P38405 GNAL Hsap 69ea894900001010 "OR1A1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by 3- methyl-2,4-nonanedione(Human)." NCBITaxon:9606 gomodel:69ea894900001010/69ea894900001013 GO:0003925 G protein activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0009898 cytoplasmic side of plasma membrane false UniProtKB:O60266 ADCY3 Hsap 69ea894900001010 "OR1A1-mediated olfactory signaling via G-alpha-olf (""olfactory"", activating adenylate cyclase) following activation by 3- methyl-2,4-nonanedione(Human)." NCBITaxon:9606 gomodel:69ea894900001010/69ea894900001015 GO:0004016 adenylate cyclase activity GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0005886 plasma membrane false UniProtKB:P08294 SOD3 Hsap 69ea894900001492 Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) NCBITaxon:9606 gomodel:69ea894900001492/69ea894900001980 GO:0004784 superoxide dismutase activity GO:0019430 removal of superoxide radicals GO:0005576 extracellular region false UniProtKB:O00244 ATOX1 Hsap 69ea894900001492 Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) NCBITaxon:9606 gomodel:69ea894900001492/69ea894900001987 GO:0016531 copper chaperone activity GO:0006825 copper ion transport GO:0005829 cytosol false UniProtKB:Q04656 ATP7A Hsap 69ea894900001492 Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) NCBITaxon:9606 gomodel:69ea894900001492/69ea894900001996 GO:0005375 copper ion transmembrane transporter activity GO:0060003 copper ion export GO:0032588 trans-Golgi network membrane false UniProtKB:O00244 ATOX1 Hsap 69ea894900001492 Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) NCBITaxon:9606 gomodel:69ea894900001492/69ea894900002007 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0006979 response to oxidative stress GO:0005634 nucleus false UniProtKB:O15431 SLC31A1 Hsap 69ea894900001492 Regulation of removal of superoxide radicals by ATOX1 through regulation of SOD3 activity. (Human) NCBITaxon:9606 gomodel:69ea894900001492/69ea894900002175 GO:0005375 copper ion transmembrane transporter activity GO:0015677 copper ion import GO:0005886 plasma membrane false UniProtKB:P04001 OPN1MW Hsap 69ea894900003563 Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003563/69ea894900003564 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P19087 GNAT2 Hsap 69ea894900003563 Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003563/69ea894900003572 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:Q13956 PDE6H Hsap 69ea894900003563 Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003563/69ea894900003589 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P51160 PDE6C Hsap 69ea894900003563 Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003563/69ea894900003601 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0120201 cone photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 69ea894900003563 Green light signaling mediated by OPN1MW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003563/69ea894900003612 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0120201 cone photoreceptor disc membrane false UniProtKB:P0DN77 OPN1MW2 Hsap 69ea894900003638 Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003638/69ea894900003639 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P19087 GNAT2 Hsap 69ea894900003638 Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003638/69ea894900003647 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:Q13956 PDE6H Hsap 69ea894900003638 Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003638/69ea894900003664 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P51160 PDE6C Hsap 69ea894900003638 Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003638/69ea894900003676 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0120201 cone photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 69ea894900003638 Green light signaling mediated by OPN1MW2 photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003638/69ea894900003687 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0120201 cone photoreceptor disc membrane false UniProtKB:P03999 OPN1SW Hsap 69ea894900003713 Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003713/69ea894900003714 GO:0008020 G protein-coupled photoreceptor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P19087 GNAT2 Hsap 69ea894900003713 Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003713/69ea894900003722 GO:0003925 G protein activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:Q13956 PDE6H Hsap 69ea894900003713 Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003713/69ea894900003739 GO:0004857 enzyme inhibitor activity GO:0141190 transducin-mediated opsin signaling pathway GO:0120201 cone photoreceptor disc membrane false UniProtKB:P51160 PDE6C Hsap 69ea894900003713 Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003713/69ea894900003751 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay GO:0120201 cone photoreceptor disc membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 69ea894900003713 Blue light signaling mediated by OPN1SW photoreceptor via G-alpha-t (transducin)_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900003713/69ea894900003762 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0042622 photoreceptor outer segment membrane false GO:0017071 intracellular cyclic nucleotide activated cation channel complex 69ea894900004256 CNG channel transport by ankyrin-G/ANK3_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900004256/69ea894900004257 GO:0005223 intracellularly cGMP-activated cation channel activity GO:0007601 visual perception GO:0042622 photoreceptor outer segment membrane false UniProtKB:Q12955 ANK3 Hsap 69ea894900004256 CNG channel transport by ankyrin-G/ANK3_Visual perception (Human) NCBITaxon:9606 gomodel:69ea894900004256/69ea894900004343 GO:0106006 cytoskeletal protein-membrane anchor activity GO:0072659 protein localization to plasma membrane GO:0042622 photoreceptor outer segment membrane false