summary:
  count: 152
  by_action:
    MODIFY: 31
    NEW: 14
    MARK_AS_OVER_ANNOTATED: 13
    KEEP_AS_NON_CORE: 38
    UNDECIDED: 6
    REMOVE: 14
    ACCEPT: 36
  by_evidence:
    IEA: 43
    IDA: 23
    IBA: 21
    ISS: 14
    IMP: 24
    IGI: 4
    IPI: 3
    NAS: 3
    TAS: 8
    EXP: 1
    ISO: 4
    IEP: 1
    RCA: 3
rows:
- file: genes/ANOGA/PGRPLD/PGRPLD-ai-review.yaml
  gene: PGRPLD
  evidence_type: IEA
  action: MODIFY
  term: GO:0045087 innate immune response
  replacement:
  - GO:0045824 negative regulation of innate immune response
  match: direction of regulation
- file: genes/ARATH/MLO2/MLO2-ai-review.yaml
  gene: MLO2
  evidence_type: IEA
  action: MODIFY
  term: GO:0006952 defense response
  replacement:
  - GO:0031348 negative regulation of defense response
  match: direction of effect
- file: genes/ARATH/WOX5/WOX5-ai-review.yaml
  gene: WOX5
  evidence_type: IDA
  action: NEW
  term: GO:0045892 negative regulation of DNA-templated transcription
  replacement: []
  match: direction of regulation
- file: genes/CHLRE/BST1/BST1-ai-review.yaml
  gene: BST1
  evidence_type: IBA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0019684 photosynthesis, light reaction
  replacement: []
  match: opposite direction
- file: genes/CHLRE/BST2/BST2-ai-review.yaml
  gene: BST2
  evidence_type: IBA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0019684 photosynthesis, light reaction
  replacement: []
  match: opposite direction
- file: genes/CHLRE/BST3/BST3-ai-review.yaml
  gene: BST3
  evidence_type: IBA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0019684 photosynthesis, light reaction
  replacement: []
  match: opposite direction
- file: genes/DROME/Got1/Got1-ai-review.yaml
  gene: Got1
  evidence_type: ISS
  action: KEEP_AS_NON_CORE
  term: GO:0006538 L-glutamate catabolic process
  replacement: []
  match: reverse direction
- file: genes/DROME/Lkb1/Lkb1-ai-review.yaml
  gene: Lkb1
  evidence_type: IMP
  action: MODIFY
  term: GO:0008284 positive regulation of cell population proliferation
  replacement:
  - GO:0008285 negative regulation of cell population proliferation
  match: opposite sign
- file: genes/DROME/cpa/cpa-ai-review.yaml
  gene: cpa
  evidence_type: IDA
  action: KEEP_AS_NON_CORE
  term: GO:0051491 positive regulation of filopodium assembly
  replacement: []
  match: opposite sign
- file: genes/DROME/tws/tws-ai-review.yaml
  gene: tws
  evidence_type: IMP
  action: UNDECIDED
  term: GO:0045880 positive regulation of smoothened signaling pathway
  replacement: []
  match: sign conflict
- file: genes/ECOLI/casE/casE-ai-review.yaml
  gene: casE
  evidence_type: IMP
  action: NEW
  term: GO:0043571 maintenance of CRISPR repeat elements
  replacement: []
  match: opposite direction
- file: genes/ECOLI/ygbT/ygbT-ai-review.yaml
  gene: ygbT
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0006974 DNA damage response
  replacement: []
  match: opposite direction
- file: genes/HETGA/Cgas/Cgas-ai-review.yaml
  gene: Cgas
  evidence_type: IEA
  action: REMOVE
  term: GO:2000042 negative regulation of double-strand break repair via homologous recombination
  replacement:
  - GO:1905168 positive regulation of double-strand break repair via homologous recombination
  match: sign inver
- file: genes/HETGA/Tac1/Tac1-ai-review.yaml
  gene: Tac1
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0006954 inflammatory response
  replacement: []
  match: opposite direction
- file: genes/HORVU/MLO/MLO-ai-review.yaml
  gene: MLO
  evidence_type: IEA
  action: MODIFY
  term: GO:0006952 defense response
  replacement:
  - GO:0031348 negative regulation of defense response
  match: direction of effect
- file: genes/MYTGA/A0A8B6GS20/A0A8B6GS20-ai-review.yaml
  gene: A0A8B6GS20
  evidence_type: IEA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0010507 negative regulation of autophagy
  replacement: []
  match: direction of effect
- file: genes/NEUCR/al-2/al-2-ai-review.yaml
  gene: al-2
  evidence_type: IEA
  action: REMOVE
  term: GO:0004311 geranylgeranyl diphosphate synthase activity
  replacement: []
  match: opposite direction
- file: genes/ORYSJ/LSD1/LSD1-ai-review.yaml
  gene: LSD1
  evidence_type: IEA
  action: MODIFY
  term: GO:0009626 plant-type hypersensitive response
  replacement:
  - GO:0034051 negative regulation of plant-type hypersensitive response
  match: opposite direction
- file: genes/ORYSJ/TUD1/TUD1-ai-review.yaml
  gene: TUD1
  evidence_type: IBA
  action: ACCEPT
  term: GO:1900457 regulation of brassinosteroid mediated signaling pathway
  replacement: []
  match: direction of regulation
- file: genes/ORYSJ/TUD1/TUD1-ai-review.yaml
  gene: TUD1
  evidence_type: IMP
  action: NEW
  term: GO:1900459 positive regulation of brassinosteroid mediated signaling pathway
  replacement: []
  match: direction of regulation
- file: genes/PSEPK/galR/galR-ai-review.yaml
  gene: galR
  evidence_type: IEA
  action: MODIFY
  term: GO:0006355 regulation of DNA-templated transcription
  replacement:
  - GO:0045893 positive regulation of DNA-templated transcription
  match: direction of regulation
- file: genes/SCHPO/cbl1/cbl1-ai-review.yaml
  gene: cbl1
  evidence_type: IBA
  action: MODIFY
  term: GO:0019346 obsolete transsulfuration
  replacement:
  - GO:0071269 L-homocysteine biosynthetic process
  match: reverse direction
- file: genes/SCHPO/cbl1/cbl1-ai-review.yaml
  gene: cbl1
  evidence_type: IEA
  action: MODIFY
  term: GO:0019346 obsolete transsulfuration
  replacement:
  - GO:0071269 L-homocysteine biosynthetic process
  match: reverse direction
- file: genes/SCHPO/maa1/maa1-ai-review.yaml
  gene: maa1
  evidence_type: ISS
  action: MODIFY
  term: GO:0006536 glutamate metabolic process
  replacement:
  - GO:0097054 L-glutamate biosynthetic process
  match: reverse direction
- file: genes/SCHPO/rum1/rum1-ai-review.yaml
  gene: rum1
  evidence_type: IMP
  action: MODIFY
  term: GO:0007089 traversing start control point of mitotic cell cycle
  replacement:
  - GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
  match: wrong sign
- file: genes/SCHPO/zds1/zds1-ai-review.yaml
  gene: zds1
  evidence_type: IBA
  action: MODIFY
  term: GO:0004864 protein phosphatase inhibitor activity
  replacement:
  - GO:0019888 protein phosphatase regulator activity
  match: direction of regulation
- file: genes/SIRV1/orf114/orf114-ai-review.yaml
  gene: '114'
  evidence_type: IDA
  action: NEW
  term: GO:0004521 RNA endonuclease activity
  replacement: []
  match: opposite direction
- file: genes/STRPU/GataC/GataC-ai-review.yaml
  gene: GataC
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006357 regulation of transcription by RNA polymerase II
  replacement: []
  match: direction of regulation
- file: genes/XENLA/sox8/sox8-ai-review.yaml
  gene: sox8
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006357 regulation of transcription by RNA polymerase II
  replacement: []
  match: direction of regulation
- file: genes/YEREN/sctN/sctN-ai-review.yaml
  gene: sctN
  evidence_type: IEA
  action: REMOVE
  term: GO:0006754 ATP biosynthetic process
  replacement: []
  match: opposite direction
- file: genes/human/AADAC/AADAC-ai-review.yaml
  gene: AADAC
  evidence_type: IDA
  action: REMOVE
  term: GO:0098754 detoxification
  replacement: []
  match: opposite direction
- file: genes/human/AAK1/AAK1-ai-review.yaml
  gene: AAK1
  evidence_type: IMP
  action: ACCEPT
  term: GO:2000369 regulation of clathrin-dependent endocytosis
  replacement: []
  match: direction of effect
- file: genes/human/AAMDC/AAMDC-ai-review.yaml
  gene: AAMDC
  evidence_type: IMP
  action: NEW
  term: GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
  replacement: []
  match: direction of effect
- file: genes/human/ABCC8/ABCC8-ai-review.yaml
  gene: ABCC8
  evidence_type: IEA
  action: MODIFY
  term: GO:1905604 negative regulation of blood-brain barrier permeability
  replacement:
  - GO:1905605 positive regulation of blood-brain barrier permeability
  match: sign correct
- file: genes/human/ACAP2/ACAP2-ai-review.yaml
  gene: ACAP2
  evidence_type: ISS
  action: ACCEPT
  term: GO:0032456 endocytic recycling
  replacement: []
  match: direction of effect
- file: genes/human/ACTR5/ACTR5-ai-review.yaml
  gene: ACTR5
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0006355 regulation of DNA-templated transcription
  replacement: []
  match: opposite sign
- file: genes/human/ACTR5/ACTR5-ai-review.yaml
  gene: ACTR5
  evidence_type: IMP
  action: NEW
  term: GO:0000122 negative regulation of transcription by RNA polymerase II
  replacement: []
  match: opposite sign
- file: genes/human/ACTRT3/ACTRT3-ai-review.yaml
  gene: ACTRT3
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0015629 actin cytoskeleton
  replacement: []
  match: opposite direction
- file: genes/human/ADAM17/ADAM17-ai-review.yaml
  gene: ADAM17
  evidence_type: IMP
  action: REMOVE
  term: GO:0043130 ubiquitin binding
  replacement: []
  match: opposite direction
- file: genes/human/ADGB/ADGB-ai-review.yaml
  gene: ADGB
  evidence_type: IEA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0006508 proteolysis
  replacement: []
  match: opposite direction
- file: genes/human/ADIPOQ/ADIPOQ-ai-review.yaml
  gene: ADIPOQ
  evidence_type: ISS
  action: REMOVE
  term: GO:0120162 positive regulation of cold-induced thermogenesis
  replacement: []
  match: Sign inver
- file: genes/human/ADIPOQ/ADIPOQ-ai-review.yaml
  gene: ADIPOQ
  evidence_type: ISS
  action: REMOVE
  term: GO:0120163 negative regulation of cold-induced thermogenesis
  replacement: []
  match: Sign inver
- file: genes/human/ADNP/ADNP-ai-review.yaml
  gene: ADNP
  evidence_type: IEA
  action: UNDECIDED
  term: GO:0010976 positive regulation of neuron projection development
  replacement: []
  match: opposite sign
- file: genes/human/ADNP/ADNP-ai-review.yaml
  gene: ADNP
  evidence_type: IEA
  action: UNDECIDED
  term: GO:0045773 positive regulation of axon extension
  replacement: []
  match: sign inver
- file: genes/human/ADPRHL1/ADPRHL1-ai-review.yaml
  gene: ADPRHL1
  evidence_type: IEA
  action: REMOVE
  term: GO:0003875 ADP-ribosylarginine-[protein] hydrolase activity
  replacement: []
  match: opposite sign
- file: genes/human/AEBP2/AEBP2-ai-review.yaml
  gene: AEBP2
  evidence_type: IBA
  action: ACCEPT
  term: GO:0006357 regulation of transcription by RNA polymerase II
  replacement: []
  match: opposite direction
- file: genes/human/AFF1/AFF1-ai-review.yaml
  gene: AFF1
  evidence_type: IDA
  action: ACCEPT
  term: GO:0006974 DNA damage response
  replacement: []
  match: opposite direction
- file: genes/human/AFF3/AFF3-ai-review.yaml
  gene: AFF3
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0035116 embryonic hindlimb morphogenesis
  replacement: []
  match: direction of effect
- file: genes/human/AFF3/AFF3-ai-review.yaml
  gene: AFF3
  evidence_type: ISS
  action: NEW
  term: GO:0001822 kidney development
  replacement: []
  match: opposite direction
- file: genes/human/AGT/AGT-ai-review.yaml
  gene: AGT
  evidence_type: IGI
  action: MODIFY
  term: GO:1901201 regulation of extracellular matrix assembly
  replacement:
  - GO:1901203 positive regulation of extracellular matrix assembly
  match: direction of effect
- file: genes/human/AGT/AGT-ai-review.yaml
  gene: AGT
  evidence_type: IGI
  action: MODIFY
  term: GO:1903598 positive regulation of gap junction assembly
  replacement:
  - GO:1903597 negative regulation of gap junction assembly
  match: sign inver
- file: genes/human/AK2/AK2-ai-review.yaml
  gene: AK2
  evidence_type: IEA
  action: ACCEPT
  term: GO:0046033 AMP metabolic process
  replacement: []
  match: reverse direction
- file: genes/human/AKR1D1/AKR1D1-ai-review.yaml
  gene: AKR1D1
  evidence_type: IEA
  action: ACCEPT
  term: GO:0047787 Delta4-3-oxosteroid 5beta-reductase activity
  replacement: []
  match: reverse direction
- file: genes/human/AKT1/AKT1-ai-review.yaml
  gene: AKT1
  evidence_type: IPI
  action: REMOVE
  term: GO:0005515 protein binding
  replacement: []
  match: direction of regulation
- file: genes/human/AP3D1/AP3D1-ai-review.yaml
  gene: AP3D1
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0048499 synaptic vesicle membrane organization
  replacement: []
  match: opposite direction
- file: genes/human/AP3S1/AP3S1-ai-review.yaml
  gene: AP3S1
  evidence_type: NAS
  action: KEEP_AS_NON_CORE
  term: GO:0036465 synaptic vesicle recycling
  replacement: []
  match: opposite direction
- file: genes/human/APLN/APLN-ai-review.yaml
  gene: APLN
  evidence_type: TAS
  action: MODIFY
  term: GO:0006955 immune response
  replacement:
  - GO:0001818 negative regulation of cytokine production
  match: opposite direction
- file: genes/human/APLN/APLN-ai-review.yaml
  gene: APLN
  evidence_type: ISS
  action: NEW
  term: GO:0090278 negative regulation of peptide hormone secretion
  replacement: []
  match: opposite direction
- file: genes/human/APOC4/APOC4-ai-review.yaml
  gene: APOC4
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0070328 triglyceride homeostasis
  replacement: []
  match: direction of effect
- file: genes/human/ARHGAP11B/ARHGAP11B-ai-review.yaml
  gene: ARHGAP11B
  evidence_type: IDA
  action: ACCEPT
  term: GO:0043547 positive regulation of GTPase activity
  replacement: []
  match: opposite direction
- file: genes/human/ARHGAP21/ARHGAP21-ai-review.yaml
  gene: ARHGAP21
  evidence_type: IMP
  action: NEW
  term: GO:0034333 adherens junction assembly
  replacement: []
  match: opposite direction
- file: genes/human/ASS1/ASS1-ai-review.yaml
  gene: ASS1
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0060416 response to growth hormone
  replacement: []
  match: direction of regulation
- file: genes/human/ATP6V0C/ATP6V0C-ai-review.yaml
  gene: ATP6V0C
  evidence_type: IEA
  action: REMOVE
  term: GO:0015986 proton motive force-driven ATP synthesis
  replacement: []
  match: OPPOSITE direction
- file: genes/human/ATP8A2/ATP8A2-ai-review.yaml
  gene: ATP8A2
  evidence_type: IEA
  action: MODIFY
  term: GO:0090556 phosphatidylserine floppase activity
  replacement:
  - GO:0140346 phosphatidylserine flippase activity
  match: reverse direction
- file: genes/human/BACC1/BACC1-ai-review.yaml
  gene: BACC1
  evidence_type: IMP
  action: NEW
  term: GO:0003714 transcription corepressor activity
  replacement: []
  match: opposite sign
- file: genes/human/BCL10/BCL10-ai-review.yaml
  gene: BCL10
  evidence_type: NAS
  action: MODIFY
  term: GO:0043122 regulation of canonical NF-kappaB signal transduction
  replacement:
  - GO:0043123 positive regulation of canonical NF-kappaB signal transduction
  match: direction of regulation
- file: genes/human/BCL2L1/BCL2L1-ai-review.yaml
  gene: BCL2L1
  evidence_type: IBA
  action: ACCEPT
  term: GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
  replacement: []
  match: direction of regulation
- file: genes/human/BLVRA/BLVRA-ai-review.yaml
  gene: BLVRA
  evidence_type: IEA
  action: ACCEPT
  term: GO:0004074 biliverdin reductase [NAD(P)H] activity
  replacement: []
  match: reverse direction
- file: genes/human/BMP4/BMP4-ai-review.yaml
  gene: BMP4
  evidence_type: IDA
  action: KEEP_AS_NON_CORE
  term: GO:0010628 positive regulation of gene expression
  replacement: []
  match: opposite direction
- file: genes/human/BMP4/BMP4-ai-review.yaml
  gene: BMP4
  evidence_type: IDA
  action: KEEP_AS_NON_CORE
  term: GO:0010629 negative regulation of gene expression
  replacement: []
  match: opposite direction
- file: genes/human/BMP4/BMP4-ai-review.yaml
  gene: BMP4
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0090189 regulation of branching involved in ureteric bud morphogenesis
  replacement: []
  match: direction of effect
- file: genes/human/BMP4/BMP4-ai-review.yaml
  gene: BMP4
  evidence_type: IDA
  action: KEEP_AS_NON_CORE
  term: GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
  replacement: []
  match: direction of effect
- file: genes/human/BMP4/BMP4-ai-review.yaml
  gene: BMP4
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis
  replacement: []
  match: direction of effect
- file: genes/human/BPTF/BPTF-ai-review.yaml
  gene: BPTF
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006357 regulation of transcription by RNA polymerase II
  replacement: []
  match: direction of regulation
- file: genes/human/BRCA2/BRCA2-ai-review.yaml
  gene: BRCA2
  evidence_type: IEA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  replacement: []
  match: direction of effect
- file: genes/human/C2CD3/C2CD3-ai-review.yaml
  gene: C2CD3
  evidence_type: IDA
  action: ACCEPT
  term: GO:0061511 centriole elongation
  replacement: []
  match: opposite direction
- file: genes/human/C5orf46/C5orf46-ai-review.yaml
  gene: C5orf46
  evidence_type: IDA
  action: NEW
  term: GO:0050829 defense response to Gram-negative bacterium
  replacement: []
  match: opposite direction
- file: genes/human/C5orf46/C5orf46-ai-review.yaml
  gene: C5orf46
  evidence_type: IDA
  action: NEW
  term: GO:0031640 killing of cells of another organism
  replacement: []
  match: opposite direction
- file: genes/human/CAMTA1/CAMTA1-ai-review.yaml
  gene: CAMTA1
  evidence_type: IEA
  action: ACCEPT
  term: GO:0045944 positive regulation of transcription by RNA polymerase II
  replacement: []
  match: direction of regulation
- file: genes/human/CASK/CASK-ai-review.yaml
  gene: CASK
  evidence_type: TAS
  action: KEEP_AS_NON_CORE
  term: GO:0007155 cell adhesion
  replacement: []
  match: direction of effect
- file: genes/human/CASP12/CASP12-ai-review.yaml
  gene: CASP12
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0050729 positive regulation of inflammatory response
  replacement: []
  match: Direction of effect
- file: genes/human/CASS4/CASS4-ai-review.yaml
  gene: CASS4
  evidence_type: IBA
  action: MODIFY
  term: GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
  replacement:
  - GO:0007229 integrin-mediated signaling pathway
  match: wrong sign
- file: genes/human/CAV1/CAV1-ai-review.yaml
  gene: CAV1
  evidence_type: IEA
  action: UNDECIDED
  term: GO:0090090 negative regulation of canonical Wnt signaling pathway
  replacement: []
  match: opposite direction
- file: genes/human/CAV1/CAV1-ai-review.yaml
  gene: CAV1
  evidence_type: ISS
  action: UNDECIDED
  term: GO:0090090 negative regulation of canonical Wnt signaling pathway
  replacement: []
  match: opposite direction
- file: genes/human/CBFB/CBFB-ai-review.yaml
  gene: CBFB
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006355 regulation of DNA-templated transcription
  replacement: []
  match: direction of regulation
- file: genes/human/CD2AP/CD2AP-ai-review.yaml
  gene: CD2AP
  evidence_type: IPI
  action: KEEP_AS_NON_CORE
  term: GO:0005515 protein binding
  replacement: []
  match: reverse direction
- file: genes/human/CD40LG/CD40LG-ai-review.yaml
  gene: CD40LG
  evidence_type: TAS
  action: KEEP_AS_NON_CORE
  term: GO:0031295 T cell costimulation
  replacement: []
  match: reverse sign
- file: genes/human/CD40LG/CD40LG-ai-review.yaml
  gene: CD40LG
  evidence_type: IBA
  action: ACCEPT
  term: GO:0043123 positive regulation of canonical NF-kappaB signal transduction
  replacement: []
  match: reverse sign
- file: genes/human/CD70/CD70-ai-review.yaml
  gene: CD70
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0042100 B cell proliferation
  replacement: []
  match: reverse sign
- file: genes/human/CD86/CD86-ai-review.yaml
  gene: CD86
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0007165 signal transduction
  replacement: []
  match: reverse sign
- file: genes/human/CD86/CD86-ai-review.yaml
  gene: CD86
  evidence_type: TAS
  action: MODIFY
  term: GO:0038023 signaling receptor activity
  replacement:
  - GO:0048018 receptor ligand activity
  match: reverse sign
- file: genes/human/CD86/CD86-ai-review.yaml
  gene: CD86
  evidence_type: ISS
  action: KEEP_AS_NON_CORE
  term: GO:0042113 B cell activation
  replacement: []
  match: reverse sign
- file: genes/human/CDC73/CDC73-ai-review.yaml
  gene: CDC73
  evidence_type: IMP
  action: MODIFY
  term: GO:1902808 positive regulation of cell cycle G1/S phase transition
  replacement:
  - GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
  match: opposite direction
- file: genes/human/CTCF/CTCF-ai-review.yaml
  gene: CTCF
  evidence_type: IMP
  action: MODIFY
  term: GO:0045893 positive regulation of DNA-templated transcription
  replacement:
  - GO:0045944 positive regulation of transcription by RNA polymerase II
  match: opposite direction
- file: genes/human/DAP/DAP-ai-review.yaml
  gene: DAP
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006914 autophagy
  replacement: []
  match: direction of regulation
- file: genes/human/DYNLT1/DYNLT1-ai-review.yaml
  gene: DYNLT1
  evidence_type: NAS
  action: UNDECIDED
  term: GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint
  replacement: []
  match: opposite sign
- file: genes/human/ECHS1/ECHS1-ai-review.yaml
  gene: ECHS1
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0018812 3-hydroxyacyl-CoA dehydratase activity
  replacement: []
  match: opposite direction
- file: genes/human/EN2/EN2-ai-review.yaml
  gene: EN2
  evidence_type: IBA
  action: ACCEPT
  term: GO:0006357 regulation of transcription by RNA polymerase II
  replacement: []
  match: direction of effect
- file: genes/human/FGF2/FGF2-ai-review.yaml
  gene: FGF2
  evidence_type: IDA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0030214 hyaluronan catabolic process
  replacement: []
  match: opposite direction
- file: genes/human/FTO/FTO-ai-review.yaml
  gene: FTO
  evidence_type: IDA
  action: ACCEPT
  term: GO:0035515 oxidative RNA demethylase activity
  replacement: []
  match: direction of effect
- file: genes/human/GNAI2/GNAI2-ai-review.yaml
  gene: GNAI2
  evidence_type: IEA
  action: MODIFY
  term: GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
  replacement:
  - GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
  match: Sign error
- file: genes/human/HADHA/HADHA-ai-review.yaml
  gene: HADHA
  evidence_type: EXP
  action: MODIFY
  term: GO:0018812 3-hydroxyacyl-CoA dehydratase activity
  replacement:
  - GO:0004300 enoyl-CoA hydratase activity
  match: reverse direction
- file: genes/human/HLA-DPA1/HLA-DPA1-ai-review.yaml
  gene: HLA-DPA1
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0050778 positive regulation of immune response
  replacement: []
  match: direction of effect
- file: genes/human/HRC/HRC-ai-review.yaml
  gene: HRC
  evidence_type: IGI
  action: MODIFY
  term: GO:0045823 positive regulation of heart contraction
  replacement:
  - GO:0045822 regulation of heart contraction
  match: direction of effect
- file: genes/human/IGFBP5/IGFBP5-ai-review.yaml
  gene: IGFBP5
  evidence_type: IGI
  action: KEEP_AS_NON_CORE
  term: GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
  replacement: []
  match: opposite direction
- file: genes/human/LOXL3/LOXL3-ai-review.yaml
  gene: LOXL3
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:2000329 negative regulation of T-helper 17 cell lineage commitment
  replacement: []
  match: direction of regulation
- file: genes/human/LOXL3/LOXL3-ai-review.yaml
  gene: LOXL3
  evidence_type: IDA
  action: KEEP_AS_NON_CORE
  term: GO:2000329 negative regulation of T-helper 17 cell lineage commitment
  replacement: []
  match: direction of regulation
- file: genes/human/LOXL3/LOXL3-ai-review.yaml
  gene: LOXL3
  evidence_type: ISS
  action: KEEP_AS_NON_CORE
  term: GO:2000329 negative regulation of T-helper 17 cell lineage commitment
  replacement: []
  match: direction of regulation
- file: genes/human/MAGI3/MAGI3-ai-review.yaml
  gene: MAGI3
  evidence_type: IDA
  action: NEW
  term: GO:0070372 regulation of ERK1 and ERK2 cascade
  replacement: []
  match: opposite direction
- file: genes/human/MCL1/MCL1-ai-review.yaml
  gene: MCL1
  evidence_type: IBA
  action: MODIFY
  term: GO:0043525 positive regulation of neuron apoptotic process
  replacement:
  - GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
  match: wrong sign
- file: genes/human/NAT10/NAT10-ai-review.yaml
  gene: NAT10
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0032211 negative regulation of telomere maintenance via telomerase
  replacement: []
  match: opposite sign
- file: genes/human/NDUFS4/NDUFS4-ai-review.yaml
  gene: NDUFS4
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0072593 reactive oxygen species metabolic process
  replacement: []
  match: direction of effect
- file: genes/human/NF1/NF1-ai-review.yaml
  gene: NF1
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0001953 negative regulation of cell-matrix adhesion
  replacement: []
  match: direction of regulation
- file: genes/human/OTX2/OTX2-ai-review.yaml
  gene: OTX2
  evidence_type: TAS
  action: ACCEPT
  term: GO:0030900 forebrain development
  replacement: []
  match: opposite direction
- file: genes/human/P2RX7/P2RX7-ai-review.yaml
  gene: P2RX7
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0043025 neuronal cell body
  replacement: []
  match: opposite direction
- file: genes/human/P2RX7/P2RX7-ai-review.yaml
  gene: P2RX7
  evidence_type: IEA
  action: KEEP_AS_NON_CORE
  term: GO:0045202 synapse
  replacement: []
  match: opposite direction
- file: genes/human/PAFAH1B1/PAFAH1B1-ai-review.yaml
  gene: PAFAH1B1
  evidence_type: ISS
  action: NEW
  term: GO:0030234 enzyme regulator activity
  replacement: []
  match: direction of regulation
- file: genes/human/PGM1/PGM1-ai-review.yaml
  gene: PGM1
  evidence_type: TAS
  action: ACCEPT
  term: GO:0005829 cytosol
  replacement: []
  match: reverse direction
- file: genes/human/PINK1/PINK1-ai-review.yaml
  gene: PINK1
  evidence_type: IMP
  action: MODIFY
  term: GO:0090200 positive regulation of release of cytochrome c from mitochondria
  replacement:
  - GO:0090201 negative regulation of release of cytochrome c from mitochondria
  match: opposite direction
- file: genes/human/RAF1/RAF1-ai-review.yaml
  gene: RAF1
  evidence_type: TAS
  action: MODIFY
  term: GO:0006915 apoptotic process
  replacement:
  - GO:0043066 negative regulation of apoptotic process
  match: opposite sign
- file: genes/human/RRM2B/RRM2B-ai-review.yaml
  gene: RRM2B
  evidence_type: IDA
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
  replacement: []
  match: opposite direction
- file: genes/human/RUNX3/RUNX3-ai-review.yaml
  gene: RUNX3
  evidence_type: IEA
  action: ACCEPT
  term: GO:0045893 positive regulation of DNA-templated transcription
  replacement: []
  match: direction of regulation
- file: genes/human/RUNX3/RUNX3-ai-review.yaml
  gene: RUNX3
  evidence_type: IDA
  action: ACCEPT
  term: GO:0045893 positive regulation of DNA-templated transcription
  replacement: []
  match: direction of regulation
- file: genes/human/SLC10A4/SLC10A4-ai-review.yaml
  gene: SLC10A4
  evidence_type: IBA
  action: REMOVE
  term: GO:0015721 bile acid and bile salt transport
  replacement: []
  match: opposite sign
- file: genes/human/SLC37A4/SLC37A4-ai-review.yaml
  gene: SLC37A4
  evidence_type: IBA
  action: KEEP_AS_NON_CORE
  term: GO:0035435 phosphate ion transmembrane transport
  replacement: []
  match: opposite direction
- file: genes/human/STK36/STK36-ai-review.yaml
  gene: STK36
  evidence_type: IPI
  action: MODIFY
  term: GO:0005515 protein binding
  replacement:
  - GO:0001222 transcription corepressor binding
  match: opposite direction
- file: genes/human/STK36/STK36-ai-review.yaml
  gene: STK36
  evidence_type: IDA
  action: ACCEPT
  term: GO:0045880 positive regulation of smoothened signaling pathway
  replacement: []
  match: direction of regulation
- file: genes/human/STK36/STK36-ai-review.yaml
  gene: STK36
  evidence_type: ISS
  action: ACCEPT
  term: GO:0045880 positive regulation of smoothened signaling pathway
  replacement: []
  match: direction of regulation
- file: genes/human/STRIT1/STRIT1-ai-review.yaml
  gene: STRIT1
  evidence_type: ISS
  action: MODIFY
  term: GO:1901894 regulation of ATPase-coupled calcium transmembrane transporter activity
  replacement:
  - GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity
  match: direction of regulation
- file: genes/human/TACO1/TACO1-ai-review.yaml
  gene: TACO1
  evidence_type: IEA
  action: ACCEPT
  term: GO:0070129 regulation of mitochondrial translation
  replacement: []
  match: direction of regulation
- file: genes/human/TBX20/TBX20-ai-review.yaml
  gene: TBX20
  evidence_type: IEA
  action: REMOVE
  term: GO:0043065 positive regulation of apoptotic process
  replacement: []
  match: opposite direction
- file: genes/human/TECR/TECR-ai-review.yaml
  gene: TECR
  evidence_type: TAS
  action: MODIFY
  term: GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity
  replacement:
  - GO:0102758 very-long-chain enoyl-CoA reductase activity
  match: reverse direction
- file: genes/human/TLR4/TLR4-ai-review.yaml
  gene: TLR4
  evidence_type: IDA
  action: REMOVE
  term: GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
  replacement: []
  match: reverse direction
- file: genes/human/TUNAR/TUNAR-ai-review.yaml
  gene: TUNAR
  evidence_type: IDA
  action: ACCEPT
  term: GO:0032469 endoplasmic reticulum calcium ion homeostasis
  replacement: []
  match: opposite direction
- file: genes/human/TYMP/TYMP-ai-review.yaml
  gene: TYMP
  evidence_type: IEA
  action: ACCEPT
  term: GO:0006206 pyrimidine nucleobase metabolic process
  replacement: []
  match: reverse direction
- file: genes/human/YTHDF3/YTHDF3-ai-review.yaml
  gene: YTHDF3
  evidence_type: IMP
  action: ACCEPT
  term: GO:0043488 regulation of mRNA stability
  replacement: []
  match: direction of effect
- file: genes/mouse/Mapk3/Mapk3-ai-review.yaml
  gene: Mapk3
  evidence_type: ISO
  action: MARK_AS_OVER_ANNOTATED
  term: GO:1904262 negative regulation of TORC1 signaling
  replacement: []
  match: opposite sign
- file: genes/rat/Akt1/Akt1-ai-review.yaml
  gene: Akt1
  evidence_type: ISS
  action: MARK_AS_OVER_ANNOTATED
  term: GO:1902018 negative regulation of cilium assembly
  replacement: []
  match: opposite sign
- file: genes/rat/Akt1/Akt1-ai-review.yaml
  gene: Akt1
  evidence_type: ISO
  action: MARK_AS_OVER_ANNOTATED
  term: GO:1902018 negative regulation of cilium assembly
  replacement: []
  match: opposite sign
- file: genes/rat/Slc10a1/Slc10a1-ai-review.yaml
  gene: Slc10a1
  evidence_type: IEP
  action: REMOVE
  term: GO:0043627 response to estrogen
  replacement: []
  match: opposite direction
- file: genes/rat/Sstr5/Sstr5-ai-review.yaml
  gene: Sstr5
  evidence_type: ISO
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0060124 positive regulation of growth hormone secretion
  replacement: []
  match: sign inver
- file: genes/rat/Sstr5/Sstr5-ai-review.yaml
  gene: Sstr5
  evidence_type: ISO
  action: MARK_AS_OVER_ANNOTATED
  term: GO:0032467 positive regulation of cytokinesis
  replacement: []
  match: sign inver
- file: genes/worm/let-23/let-23-ai-review.yaml
  gene: let-23
  evidence_type: IBA
  action: ACCEPT
  term: GO:0043410 positive regulation of MAPK cascade
  replacement: []
  match: direction of regulation
- file: genes/yeast/AAT2/AAT2-ai-review.yaml
  gene: AAT2
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0032938 negative regulation of translation in response to oxidative stress
  replacement: []
  match: direction of effect
- file: genes/yeast/CLN2/CLN2-ai-review.yaml
  gene: CLN2
  evidence_type: IBA
  action: MODIFY
  term: GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
  replacement:
  - GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity
  match: Direction of regulation
- file: genes/yeast/CYS4/CYS4-ai-review.yaml
  gene: CYS4
  evidence_type: IDA
  action: ACCEPT
  term: GO:0004122 cystathionine beta-synthase activity
  replacement: []
  match: reverse direction
- file: genes/yeast/ERG24/ERG24-ai-review.yaml
  gene: ERG24
  evidence_type: RCA
  action: ACCEPT
  term: GO:0050613 Delta14-sterol reductase activity
  replacement: []
  match: reverse direction
- file: genes/yeast/ERG24/ERG24-ai-review.yaml
  gene: ERG24
  evidence_type: RCA
  action: ACCEPT
  term: GO:0050613 Delta14-sterol reductase activity
  replacement: []
  match: reverse direction
- file: genes/yeast/ERG24/ERG24-ai-review.yaml
  gene: ERG24
  evidence_type: RCA
  action: ACCEPT
  term: GO:0050613 Delta14-sterol reductase activity
  replacement: []
  match: reverse direction
- file: genes/yeast/HTD2/HTD2-ai-review.yaml
  gene: HTD2
  evidence_type: IDA
  action: ACCEPT
  term: GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
  replacement: []
  match: reverse direction
- file: genes/yeast/SAS3/SAS3-ai-review.yaml
  gene: SAS3
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0030466 silent mating-type cassette heterochromatin formation
  replacement: []
  match: opposite direction
- file: genes/yeast/SIC1/SIC1-ai-review.yaml
  gene: SIC1
  evidence_type: IMP
  action: KEEP_AS_NON_CORE
  term: GO:0016242 negative regulation of macroautophagy
  replacement: []
  match: opposite sign