{
  "family": "cyp",
  "rhea2go_go_release": "releases/2026-07-26",
  "retrieved_at": "2026-10-14T17:50:39Z",
  "ec2go_go_release": "releases/2026-07-26",
  "title": "Human cytochrome P450s",
  "entries": 60,
  "entries_with_rhea": 57,
  "reaction_annotations": 556,
  "experimental_reaction_annotations": 528,
  "distinct_reactions": 297,
  "mapped_reactions": 96,
  "unmapped_reactions": 201,
  "unmapped_reactions_without_ec": 191,
  "entries_all_reactions_unmapped": 2,
  "distinct_go_targets": 59,
  "top_go_targets": [
    [
      "GO:0004507",
      "steroid 11-beta-monooxygenase activity",
      6
    ],
    [
      "GO:0102033",
      "long-chain fatty acid omega-hydroxylase activity",
      6
    ],
    [
      "GO:0004508",
      "steroid 17-alpha-monooxygenase activity",
      5
    ],
    [
      "GO:0016712",
      "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
      4
    ],
    [
      "GO:0106256",
      "hydroperoxy icosatetraenoate dehydratase activity",
      4
    ],
    [
      "GO:0008397",
      "sterol 12-alpha-hydroxylase activity",
      3
    ],
    [
      "GO:0008398",
      "sterol 14-demethylase activity",
      3
    ],
    [
      "GO:0008404",
      "arachidonate 14,15-epoxygenase activity",
      3
    ]
  ],
  "goa_mf_rows": 1302,
  "goa_rows_from_rhea": 90,
  "entries_with_closure_gap": 0,
  "closure_gap_pairs": 0
}