# RHEA -> GO mapping (SSSOM) -- curated new mappings to fill rhea2go gaps # # These are hand-curated RHEA(reaction) -> GO(molecular function) mappings that are MISSING from the # public rhea2go (https://current.geneontology.org/ontology/external2go/rhea2go, GO release # 2026-05-19). They were found by the RHEA project's gap analysis (see ../RHEA.md, # RHEA-EC-SPECIFICITY.md, RHEA-GAP-CASES.md): each subject RHEA reaction is annotated on # Swiss-Prot enzymes but has no rhea2go row, so the activity never propagates to GO. # # Two predicate classes encode the specificity finding: # * skos:exactMatch -- the GO term IS the reaction's activity; this row is a ready-to-add rhea2go # mapping. Most are supported by an EC bridge: ec2go already maps the # reaction's EC to this exact GO term, and rhea2ec maps the reaction to that # EC (and the EC has only this one reaction), so RHEA -> GO follows. # * skos:broadMatch -- the only existing GO term is BROADER than the reaction (a class/root term); # the row records the best current target and the comment names the narrower # GO term that should be requested (proposed_new_terms). # # Provenance: every RHEA id + equation is from the UniProtKB CC CATALYTIC ACTIVITY line; every GO # id/label was verified non-obsolete against QuickGO; "absent from rhea2go" was checked against the # rhea2go file. Validate with: just validate-rhea-mappings # (linkml-validate against the SSSOM schema 'mapping set' class, then GO-label term validation). mapping_set_id: https://w3id.org/ai4curation/ai-gene-review/mappings/rhea2go mapping_set_title: RHEA to GO mapping (curated gap-fill for rhea2go) mapping_set_description: >- Curated RHEA reaction -> GO molecular-function mappings that are absent from the public rhea2go external2go mapping, identified by the RHEA-vs-EC gap analysis in projects/RHEA. exactMatch rows are ready-to-add rhea2go entries (mostly EC-bridge supported: ec2go(EC)=this GO term and rhea2ec(reaction)=that EC); broadMatch rows attach a reaction to the best available, broader GO term and flag a narrower term to request; sssom:NoTermFound rows are new-GO-term-request candidates (no suitable MF term exists). Every mapping is backed by a review of a reviewed (Swiss-Prot) enzyme that carries the reaction -- see RHEA-MAPPING-REVIEWS.md. Seeds the curation of new rhea2go mappings and quality-checks GO molecular-function annotation of the corresponding enzymes (e.g. SAMD8/SMSr Q96LT4, biotinidase BTD P43251, TPMT P51580, VKORC1L1 Q8N0U8, PYCR1 P32322, phosphoserine aminotransferase serC P23721). license: https://creativecommons.org/licenses/by/4.0/ creator_label: - AI Gene Review project mapping_date: "2026-06-20" subject_source: rhea object_source: GO curie_map: RHEA: http://rdf.rhea-db.org/ GO: http://purl.obolibrary.org/obo/GO_ skos: http://www.w3.org/2004/02/skos/core# semapv: https://w3id.org/semapv/vocab/ sssom: https://w3id.org/sssom/ obo: http://purl.obolibrary.org/obo/ mappings: # ===== exactMatch: ready-to-add rhea2go rows (GO term == the reaction's activity) ===== - subject_id: RHEA:36079 subject_label: "N-acylsphing-4-enine + 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-acylsphing-4-enine 1-phosphoethanolamine + 1,2-diacyl-sn-glycerol" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0002950 object_label: ceramide phosphoethanolamine synthase activity mapping_justification: semapv:ManualMappingCuration comment: >- The defining SMSr (SAMD8, Q96LT4) reaction. GO:0002950 already exists but is not on the protein and the reaction has no rhea2go row, so the activity fell through the cracks (gap class G6, pure propagation gap -- no new GO term needed). Cleanest case to add to rhea2go. - subject_id: RHEA:13493 subject_label: "(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004455 object_label: ketol-acid reductoisomerase activity mapping_justification: semapv:ManualMappingCuration comment: >- EC-bridge supported: rhea2ec maps RHEA:13493 to EC 1.1.1.86 and ec2go maps EC 1.1.1.86 to exactly GO:0004455; EC 1.1.1.86 has this single reaction, so RHEA -> GO is unambiguous. Branched-chain amino-acid biosynthesis (IlvC). Absent from rhea2go. - subject_id: RHEA:15333 subject_label: "(S)-ureidoglycolate + NADP(+) = N-carbamoyl-2-oxoglycine + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0009040 object_label: ureidoglycolate dehydrogenase activity mapping_justification: semapv:ManualMappingCuration comment: >- EC-bridge supported via EC 1.1.1.154 -> GO:0009040 (single reaction for the EC). Purine/allantoin degradation. Absent from rhea2go. - subject_id: RHEA:33751 subject_label: "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008962 object_label: phosphatidylglycerophosphatase activity mapping_justification: semapv:ManualMappingCuration comment: >- EC-bridge supported via EC 3.1.3.27 -> GO:0008962 (single reaction for the EC). Phosphatidylglycerol (membrane phospholipid) biosynthesis. Absent from rhea2go. - subject_id: RHEA:64536 subject_label: "N-(2R-hydroxy-VLCFA)-(R)-4-hydroxysphingoid base + 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = inositol-phospho-ceramide + 1,2-diacyl-sn-glycerol" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0045140 object_label: inositol phosphoceramide synthase activity mapping_justification: semapv:ManualMappingCuration comment: >- EC-bridge supported via EC 2.7.1.227 -> GO:0045140 (single reaction for the EC). Fungal/plant sphingolipid biosynthesis (AUR1-type), the IPC-synthase analogue of the SMSr CPE case above. Absent from rhea2go. - subject_id: RHEA:13733 subject_label: "n-alkanal + NAD(+) = alk-2-enal + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0032440 object_label: 2-alkenal reductase [NAD(P)H] activity mapping_justification: semapv:ManualMappingCuration comment: >- EC-bridge supported via EC 1.3.1.74 -> GO:0032440 (single reaction for the EC). RHEA reactions are direction-agnostic; the GO 'reductase' term and this RHEA equation describe the same conversion. Absent from rhea2go. # ===== broadMatch: best available (broader) GO term; a narrower term should be requested ===== - subject_id: RHEA:34091 subject_label: "(5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate" predicate_id: skos:broadMatch predicate_label: broad match object_id: GO:0016829 object_label: lyase activity mapping_justification: semapv:ManualMappingCuration comment: >- PHYKPL (Q8IUZ5, EC 4.2.3.134). No GO term exists for this activity, and the EC is absent from ec2go, so the protein sits on the lyase root. PROPOSED NEW GO TERM: '5-phosphooxy-L-lysine phospho-lyase activity' (sibling of GO:0050459 ethanolamine-phosphate phospho-lyase activity), anchored to RHEA:34091 / EC 4.2.3.134; once created, replace this broadMatch with an exactMatch. - subject_id: RHEA:37667 subject_label: "GlcNAc-beta-1,4-Man-O-Thr-[protein] + UDP-N-acetyl-alpha-D-galactosamine = GalNAc-beta-1,3-GlcNAc-beta-1,4-Man-O-Thr-[protein] + UDP + H(+)" predicate_id: skos:broadMatch predicate_label: broad match object_id: GO:0008376 object_label: acetylgalactosaminyltransferase activity mapping_justification: semapv:ManualMappingCuration comment: >- B3GALNT2 (Q8NCR0, EC 2.4.1.313), an alpha-dystroglycan O-mannosyl-glycan elongation enzyme (dystroglycanopathy MDDGA11). Only the generic class term exists. PROPOSED NEW GO TERM: 'N-acetyl-beta-glucosaminyl-glycoprotein beta-1,3-N-acetylgalactosaminyltransferase activity' (child of GO:0008376), anchored to RHEA:37667 / EC 2.4.1.313. - subject_id: RHEA:26422 subject_label: "thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)" predicate_id: skos:broadMatch predicate_label: broad match object_id: GO:0004062 object_label: aryl sulfotransferase activity mapping_justification: semapv:ManualMappingCuration comment: >- SULT6B1 (Q6IMI4, thyroxine sulfotransferase). Thyroxine is an aryl (phenolic) substrate, so 'aryl sulfotransferase activity' is a correct broader term and a defensible refinement of the bare 'sulfotransferase activity' the protein currently carries. A substrate-specific 'thyroxine sulfotransferase activity' term would be exact, but the human enzyme's activity is annotated by similarity, so only the broader term is asserted here pending direct evidence. # ===== Batch 2 (2026-06-20): EC-bridge mappings, each backed by a reviewed enzyme ===== # Per-enzyme reviews in RHEA-MAPPING-REVIEWS.md. exactMatch unless marked broadMatch. - subject_id: RHEA:11536 subject_label: "choline + 2 O2 + H2O = glycine betaine + 2 H2O2 + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0033713 object_label: "choline:oxygen 1-oxidoreductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Choline oxidase (codA Q7X2H8, Arthrobacter globiformis; reviewed PE1, catalytic activity PMID:12795615). EC-bridge: ec2go maps EC 1.1.3.17 to GO:0033713 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:28106 subject_label: "galactitol 1-phosphate + NAD(+) = keto-D-tagatose 6-phosphate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008868 object_label: "galactitol-1-phosphate 5-dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Galactitol 1-phosphate 5-dehydrogenase (gatD P0A9S3, Escherichia coli; reviewed PE1, catalytic activity PMID:13331868). EC-bridge: ec2go maps EC 1.1.1.251 to GO:0008868 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:37599 subject_label: "(9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0102988 object_label: "acyl-CoA 15-desaturase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Fatty acid desaturase DES3 (DES3 Q594P3, Sorghum bicolor; reviewed PE1, catalytic activity PMID:17178719). EC-bridge: ec2go maps EC 1.14.19.13 to GO:0102988 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:41792 subject_label: "holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004314 object_label: "[acyl-carrier-protein] S-malonyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCAT Q8IVS2, Homo sapiens; reviewed PE1, catalytic activity PMID:19549604). EC-bridge: ec2go maps EC 2.3.1.39 to GO:0004314 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:42664 subject_label: "alpha-L-arabinopyanose + NADP(+) = L-arabinono-1,4-lactone + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0044103 object_label: "L-arabinose 1-dehydrogenase (NADP+) activity" mapping_justification: semapv:ManualMappingCuration comment: >- L-arabinose 1-dehydrogenase (xacB D4GP33, Haloferax volcanii; reviewed PE1, catalytic activity PMID:23949136). EC-bridge: ec2go maps EC 1.1.1.376 to GO:0044103 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:43620 subject_label: "L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0031132 object_label: "serine 3-dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- NADP-dependent 3-hydroxy acid dehydrogenase YdfG (ydfG P39831, Escherichia coli; reviewed PE1, catalytic activity PMID:12535615). EC-bridge: ec2go maps EC 1.1.1.276 to GO:0031132 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:49072 subject_label: "dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H2O + 2 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0018640 object_label: "dibenzothiophene monooxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Dibenzothiophene monooxygenase (dszC Q6WNP1, Rhodococcus erythropolis; reviewed PE1, catalytic activity PMID:24470304). EC-bridge: ec2go maps EC 1.14.14.21 to GO:0018640 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:67008 subject_label: "a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004482 object_label: "mRNA 5'-cap (guanine-N7-)-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- mRNA cap guanine-N (RNMT O43148, Homo sapiens; reviewed PE1, catalytic activity PMID:9790902). EC-bridge: ec2go maps EC 2.1.1.56 to GO:0004482 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:67012 subject_label: "a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004484 object_label: "mRNA guanylyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- mRNA-capping enzyme (RNGTT O60942, Homo sapiens; reviewed PE1, catalytic activity PMID:9473487). EC-bridge: ec2go maps EC 2.7.7.50 to GO:0004484 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:73067 subject_label: "an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0033925 object_label: "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Cytosolic endo-beta-N-acetylglucosaminidase 1 (ENGASE1 F4JZC2, Arabidopsis thaliana; reviewed PE1, catalytic activity PMID:21796445). EC-bridge: ec2go maps EC 3.2.1.96 to GO:0033925 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:76995 subject_label: "2 reduced [4Fe-4S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [4Fe-4S]-[ferredoxin] + NADPH" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004324 object_label: "ferredoxin-NADP+ reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Ferredoxin--NADP reductase A (- A9ES55, Sorangium cellulosum; reviewed PE1, catalytic activity PMID:19696019). EC-bridge: ec2go maps EC 1.18.1.2 to GO:0004324 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:77171 subject_label: "biocytin + H2O = biotin + L-lysine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047708 object_label: "biotinidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Biotinidase (BTD P43251, Homo sapiens; reviewed PE1, catalytic activity PMID:9654207). EC-bridge: ec2go maps EC 3.5.1.12 to GO:0047708 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:10908 subject_label: "glycolithocholate + 3'-phosphoadenylyl sulfate = glycolithocholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047704 object_label: "bile-salt sulfotransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Sulfotransferase 2A6 (Sult2a6 B2RVI8, Mus musculus; reviewed PE2, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.8.2.14 to GO:0047704 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:11440 subject_label: "2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0018677 object_label: "pentachlorophenol monooxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pentachlorophenol 4-monooxygenase (pcpB P42535, Sphingobium chlorophenolicum; reviewed PE1, catalytic activity PMID:25238136). EC-bridge: ec2go maps EC 1.14.13.50 to GO:0018677 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:11608 subject_label: "[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n) + n CoA" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050208 object_label: "polysialic-acid O-acetyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Polysialic acid O-acetyltransferase (neuO A1ADJ6, Escherichia coli O1:K1 / APEC; reviewed PE1, catalytic activity PMID:17519228). EC-bridge: ec2go maps EC 2.3.1.136 to GO:0050208 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:11640 subject_label: "a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 NADH + 2 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0033729 object_label: "anthocyanidin reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Anthocyanidin reductase (BAN Q9SEV0, Arabidopsis thaliana; reviewed PE1, catalytic activity PMID:14725861). EC-bridge: ec2go maps EC 1.3.1.77 to GO:0033729 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:12500 subject_label: "(3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate + NADPH + 2 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047127 object_label: "thiomorpholine-carboxylate dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Ketimine reductase mu-crystallin (CRYM Q14894, Homo sapiens; reviewed PE1, catalytic activity PMID:25931162). EC-bridge: ec2go maps EC 1.5.1.25 to GO:0047127 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:12609 subject_label: "mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + S-adenosyl-L-homocysteine + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008119 object_label: "thiopurine S-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Thiopurine S-methyltransferase (TPMT P51580, Homo sapiens; reviewed PE1, catalytic activity PMID:657528). EC-bridge: ec2go maps EC 2.1.1.67 to GO:0008119 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:12685 subject_label: "2 mycothiol + NADP(+) = mycothione + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050627 object_label: "mycothione reductase [NAD(P)H] activity" mapping_justification: semapv:ManualMappingCuration comment: >- Mycothione reductase (mtr P9WHH3, Mycobacterium tuberculosis; reviewed PE1, catalytic activity PMID:10512639). EC-bridge: ec2go maps EC 1.8.1.15 to GO:0050627 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:13817 subject_label: "phylloquinone + [protein]-disulfide + H2O = 2,3-epoxyphylloquinone + [protein]-dithiol" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047057 object_label: "vitamin-K-epoxide reductase (warfarin-sensitive) activity" mapping_justification: semapv:ManualMappingCuration comment: >- Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1 Q8N0U8, Homo sapiens; reviewed PE1, catalytic activity PMID:24532791). EC-bridge: ec2go maps EC 1.17.4.4 to GO:0047057 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:14105 subject_label: "L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004735 object_label: "pyrroline-5-carboxylate reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1 P32322, Homo sapiens; reviewed PE1, catalytic activity PMID:28258219). EC-bridge: ec2go maps EC 1.5.1.2 to GO:0004735 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:16573 subject_label: "4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004648 object_label: "O-phospho-L-serine:2-oxoglutarate transaminase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Phosphoserine aminotransferase (serC P23721, Escherichia coli; reviewed PE1, catalytic activity PMID:8706854). EC-bridge: ec2go maps EC 2.6.1.52 to GO:0004648 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:16905 subject_label: "a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047408 object_label: "alkenylglycerophosphocholine hydrolase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Lysoplasmalogenase TMEM86A (TMEM86A Q8N2M4, Homo sapiens; reviewed PE1, catalytic activity PMID:36592658). EC-bridge: ec2go maps EC 3.3.2.2 to GO:0047408 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:18021 subject_label: "a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047288 object_label: "beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1 Q11201, Homo sapiens; reviewed PE1, catalytic activity PMID:8027041). EC-bridge: ec2go maps EC 2.4.3.2 to GO:0047288 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:16981 subject_label: "3-oxoadipate + NAD(+) = maleylacetate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0018506 object_label: "maleylacetate reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Maleylacetate reductase 2 (tfdFII P94135, Cupriavidus pinatubonensis; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.3.1.32 to GO:0018506 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:14317 subject_label: "morphine + NAD(+) = morphinone + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050109 object_label: "morphine 6-dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Aldo-keto reductase family 1 member C13 (AKR1C13 P82809, Mesocricetus auratus; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.218 to GO:0050109 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:48940 subject_label: "an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid" predicate_id: skos:broadMatch predicate_label: broad match object_id: GO:0016805 object_label: "dipeptidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Dipeptidase 2 (DPEP2 Q9H4A9, Homo sapiens; reviewed PE1, PMID:32325220). EC 3.4.13.19. GO:0016805 'dipeptidase activity' is a class term; a specific membrane-dipeptidase term would be exact. Reaction absent from rhea2go. # ===== New GO term suggestions (no suitable GO MF term exists; sssom:NoTermFound) ===== - subject_id: RHEA:10808 subject_label: "(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)-epoxypropylphosphonate + 2 H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- (S)-2-hydroxypropylphosphonic acid epoxidase (hppE Q56185, Streptomyces wedmorensis; reviewed PE1, PMID:16015285; EC 1.11.1.23). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: '(S)-2-hydroxypropylphosphonic acid epoxidase activity', anchored to RHEA:10808 / EC 1.11.1.23. - subject_id: RHEA:11380 subject_label: "[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- [2-(trimethylamino)ethyl]phosphonate dioxygenase (tmpA A0A4V8H042, Leisingera caerulea; reviewed PE1, PMID:30789718; EC 1.14.11.72). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: '[2-(trimethylamino)ethyl]phosphonate dioxygenase activity', anchored to RHEA:11380 / EC 1.14.11.72. - subject_id: RHEA:11564 subject_label: "4-O-beta-D-glucopyranosyl-D-gluconate + phosphate = D-gluconate + alpha-D-glucose 1-phosphate" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Cellobionic acid phosphorylase (cbp Q8P3J4, Xanthomonas campestris pv. campestris; reviewed PE1, PMID:24055472; EC 2.4.1.321). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: 'Cellobionic acid phosphorylase activity', anchored to RHEA:11564 / EC 2.4.1.321. - subject_id: RHEA:13145 subject_label: "4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = alpha-D-mannose 1-phosphate + N-acetyl-D-glucosamine" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- 1,4-beta-mannosyl-N-acetylglucosamine phosphorylase (BT_0458 Q8A8Y4, Bacteroides thetaiotaomicron; reviewed PE1, PMID:23943617; EC 2.4.1.320). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: '1,4-beta-mannosyl-N-acetylglucosamine phosphorylase activity', anchored to RHEA:13145 / EC 2.4.1.320. # ===== Batch 3 (2026-06-20): more EC-bridge exactMatch mappings + new-term suggestions ===== # Reviews in RHEA-MAPPING-REVIEWS.md. - subject_id: RHEA:30807 subject_label: "L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050241 object_label: "pyrroline-2-carboxylate reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Ketimine reductase mu-crystallin (CRYM Q14894, Homo sapiens; reviewed PE1, catalytic activity PMID:25931162). EC-bridge: ec2go maps EC 1.5.1.1 to GO:0050241 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:17377 subject_label: "a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004169 object_label: "dolichyl-phosphate-mannose-protein mannosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Protein O-mannosyl-transferase 2 (POMT2 Q9UKY4, Homo sapiens; reviewed PE1, catalytic activity PMID:28512129). EC-bridge: ec2go maps EC 2.4.1.109 to GO:0004169 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:17901 subject_label: "xanthotoxol + S-adenosyl-L-methionine = xanthotoxin + S-adenosyl-L-homocysteine + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0030753 object_label: "8-hydroxyfuranocoumarin 8-O-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Esculetin O-methyltransferase (COMT-S A0A4P8DY91, Kitagawia praeruptora; reviewed PE1, catalytic activity PMID:30934718). EC-bridge: ec2go maps EC 2.1.1.70 to GO:0030753 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:18225 subject_label: "[N-(6-aminohexanoyl)](n) + H2O = [N-(6-aminohexanoyl)](n-1) + 6-aminohexanoate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0019875 object_label: "6-aminohexanoate-dimer hydrolase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 6-aminohexanoate-dimer hydrolase (nylB P07061, Paenarthrobacter ureafaciens; reviewed PE1, catalytic activity PMID:6389532). EC-bridge: ec2go maps EC 3.5.1.46 to GO:0019875 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:20465 subject_label: "[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050501 object_label: "hyaluronan synthase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Hyaluronan synthase 1 (HAS1 Q92839, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.4.1.212 to GO:0050501 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:20800 subject_label: "3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047238 object_label: "glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Chondroitin sulfate synthase 3 (CHSY3 Q70JA7, Homo sapiens; reviewed PE1, catalytic activity PMID:12907687). EC-bridge: ec2go maps EC 2.4.1.175 to GO:0047238 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:21924 subject_label: "3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047559 object_label: "3-dehydro-L-gulonate 2-dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 2,3-diketo-L-gulonate reductase (dlgD P37672, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.130 to GO:0047559 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:23048 subject_label: "(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047988 object_label: "hydroxyacid-oxoacid transhydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1 Q8IWW8, Homo sapiens; reviewed PE1, catalytic activity PMID:16435184). EC-bridge: ec2go maps EC 1.1.99.24 to GO:0047988 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:23240 subject_label: "(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = N-formyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0030409 object_label: "glutamate formimidoyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Formiminotransferase cyclodeaminase-like protein (FTCD-L Q9SKT4, Arabidopsis thaliana; reviewed PE2, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.1.2.5 to GO:0030409 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:23260 subject_label: "(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047034 object_label: "15-hydroxyicosatetraenoate dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 15-hydroxyprostaglandin dehydrogenase [NAD (HPGD P15428, Homo sapiens; reviewed PE1, catalytic activity PMID:8086429). EC-bridge: ec2go maps EC 1.1.1.232 to GO:0047034 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:23428 subject_label: "3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050510 object_label: "N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Chondroitin sulfate synthase 3 (CHSY3 Q70JA7, Homo sapiens; reviewed PE1, catalytic activity PMID:12907687). EC-bridge: ec2go maps EC 2.4.1.226 to GO:0050510 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:23956 subject_label: "L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004653 object_label: "polypeptide N-acetylgalactosaminyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10 Q86SR1, Homo sapiens; reviewed PE1, catalytic activity PMID:12417297). EC-bridge: ec2go maps EC 2.4.1.41 to GO:0004653 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:24670 subject_label: "hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004854 object_label: "xanthine dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Xanthine dehydrogenase/oxidase (XDH P47989, Homo sapiens; reviewed PE1, catalytic activity PMID:8670112). EC-bridge: ec2go maps EC 1.17.1.4 to GO:0004854 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:24869 subject_label: "5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0017061 object_label: "S-methyl-5-thioadenosine phosphorylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- S-methyl-5'-thioadenosine phosphorylase (mtnP Q2RXH9, Rhodospirillum rubrum; reviewed PE1, catalytic activity PMID:31950558). EC-bridge: ec2go maps EC 2.4.2.28 to GO:0017061 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:25054 subject_label: "(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047070 object_label: "3-carboxyethylcatechol 2,3-dioxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (mhpB P0ABR9, Escherichia coli; reviewed PE1, catalytic activity PMID:8752345). EC-bridge: ec2go maps EC 1.13.11.16 to GO:0047070 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:25058 subject_label: "(E)-cinnamate + NADH + O2 + H(+) = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008695 object_label: "3-phenylpropionate dioxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 3-phenylpropionate/cinnamic acid dioxygenase subunit beta (hcaF Q47140, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.14.12.19 to GO:0008695 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:25173 subject_label: "N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0016403 object_label: "dimethylargininase activity" mapping_justification: semapv:ManualMappingCuration comment: >- N (DDAH1 O94760, Homo sapiens; reviewed PE1, catalytic activity PMID:37296100). EC-bridge: ec2go maps EC 3.5.3.18 to GO:0016403 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:25193 subject_label: "(1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0018504 object_label: "cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Cis-toluene dihydrodiol dehydrogenase (todD P13859, Pseudomonas putida; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.3.1.19 to GO:0018504 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:25269 subject_label: "(R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004603 object_label: "phenylethanolamine N-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Phenylethanolamine N-methyltransferase (PNMT P11086, Homo sapiens; reviewed PE1, catalytic activity PMID:8812853). EC-bridge: ec2go maps EC 2.1.1.28 to GO:0004603 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:26269 subject_label: "Co-precorrin-2 + 3 H(+) = precorrin-2 + Co(2+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0016852 object_label: "sirohydrochlorin cobaltochelatase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Sirohydrochlorin cobaltochelatase (cbiK Q05592, Salmonella typhimurium; reviewed PE1, catalytic activity PMID:9150215). EC-bridge: ec2go maps EC 4.99.1.3 to GO:0016852 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:27846 subject_label: "(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 + H(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+) + H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008688 object_label: "3-(3-hydroxyphenyl)propionate hydroxylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 3- (mhpA P77397, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.14.13.127 to GO:0008688 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:28062 subject_label: "alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0043842 object_label: "Kdo transferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 3-deoxy-D-manno-octulosonic acid transferase (waaA P0AC75, Escherichia coli; reviewed PE1, catalytic activity PMID:1577828). EC-bridge: ec2go maps EC 2.4.99.13 to GO:0043842 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:28178 subject_label: "(9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0102895 object_label: "colneleate synthase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Divinyl ether synthase CYP74 (CYP74 Q2WE96, Allium sativum; reviewed PE1, catalytic activity PMID:9128734). EC-bridge: ec2go maps EC 4.2.1.121 to GO:0102895 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:28406 subject_label: "XTP + H2O = XDP + phosphate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0103023 object_label: "ITPase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Inosine/xanthosine triphosphatase (yjjX P39411, Escherichia coli; reviewed PE1, catalytic activity PMID:16216582). EC-bridge: ec2go maps EC 3.6.1.73 to GO:0103023 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:28418 subject_label: "4-(trimethylamino)butanoyl-CoA + (R)-carnitine = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008735 object_label: "L-carnitine CoA-transferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- L-carnitine CoA-transferase (caiB P31572, Escherichia coli; reviewed PE1, catalytic activity PMID:11551212). EC-bridge: ec2go maps EC 2.8.3.21 to GO:0008735 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:29859 subject_label: "5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008782 object_label: "adenosylhomocysteine nucleosidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN P0AF12, Escherichia coli; reviewed PE1, catalytic activity PMID:3911944). EC-bridge: ec2go maps EC 3.2.2.9 to GO:0008782 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:30367 subject_label: "adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0043755 object_label: "alpha-ribazole phosphatase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Adenosylcobalamin/alpha-ribazole phosphatase (cobC P52086, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.1.3.73 to GO:0043755 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:31375 subject_label: "pyrrole-2-carboxylate + H(+) = 1H-pyrrole + CO2" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0034941 object_label: "pyrrole-2-carboxylate decarboxylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pyrrole-2-carboxylic acid decarboxylase (hudA Q9I6N5, Pseudomonas aeruginosa; reviewed PE1, catalytic activity PMID:33763291). EC-bridge: ec2go maps EC 4.1.1.93 to GO:0034941 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:31599 subject_label: "thymine + FMNH2 + NADH + O2 = (Z)-2-methylureidoacrylate + FMN + NAD(+) + H2O + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0052614 object_label: "uracil oxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pyrimidine monooxygenase RutA (rutA P75898, Escherichia coli; reviewed PE1, catalytic activity PMID:28661684). EC-bridge: ec2go maps EC 1.14.99.46 to GO:0052614 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:31799 subject_label: "4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + NH4(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050334 object_label: "thiaminase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Aminopyrimidine aminohydrolase (tenA P25052, Bacillus subtilis; reviewed PE1, catalytic activity PMID:17618314). EC-bridge: ec2go maps EC 3.5.99.2 to GO:0050334 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:32951 subject_label: "sucrose = trehalulose" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050006 object_label: "isomaltulose synthase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Isomaltulose synthase (palI Q8KR84, Klebsiella variicola; reviewed PE1, catalytic activity PMID:12039719). EC-bridge: ec2go maps EC 5.4.99.11 to GO:0050006 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:33507 subject_label: "sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008117 object_label: "sphinganine-1-phosphate aldolase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Sphingosine-1-phosphate lyase 1 (SGPL1 O95470, Homo sapiens; reviewed PE1, catalytic activity PMID:28165339). EC-bridge: ec2go maps EC 4.1.2.27 to GO:0008117 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:33955 subject_label: "DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047254 object_label: "2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- DIMBOA UDP-glucosyltransferase BX9 (BX9 B4G072, Zea mays; reviewed PE1, catalytic activity PMID:16666853). EC-bridge: ec2go maps EC 2.4.1.202 to GO:0047254 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:33979 subject_label: "DIBOA beta-D-glucoside + H2O = DIBOA + D-glucose" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0102726 object_label: "DIMBOA glucoside beta-D-glucosidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1d, chloroplastic (GLU1D D5MTF8, Triticum aestivum; reviewed PE1, catalytic activity PMID:21875895). EC-bridge: ec2go maps EC 3.2.1.182 to GO:0102726 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. - subject_id: RHEA:13969 subject_label: "a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + GMP + diphosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0003963 object_label: "RNA-3'-phosphate cyclase activity" mapping_justification: semapv:ManualMappingCuration comment: >- RNA 3'-terminal phosphate cyclase (rtc Q8U0N7, Pyrococcus furiosus; reviewed PE1, catalytic activity PMID:22074260). EC-bridge: ec2go maps EC 6.5.1.5 to GO:0003963 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go. # --- new GO term suggestions (sssom:NoTermFound) --- - subject_id: RHEA:56516 subject_label: "Fe-coproporphyrin III + 2 H2O2 + 2 H(+) = heme b + 2 CO2 + 4 H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Coproheme decarboxylase (chdC Q8Y5F1, Listeria monocytogenes serovar 1/2a; reviewed PE1, PMID:31423350; EC 1.3.98.5). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: 'Coproheme decarboxylase activity', anchored to RHEA:56516 / EC 1.3.98.5. - subject_id: RHEA:42836 subject_label: "5 malonyl-CoA + acetyl-CoA + 3 NADPH + 7 H(+) = 5-methyl-1-naphthoate + 5 CO2 + 3 NADP(+) + 6 CoA + 4 H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- 5-methyl-1-naphthoate synthase (aziB B4XYB8, Streptomyces sahachiroi; reviewed PE1, PMID:18635006; EC 2.3.1.236). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: '5-methyl-1-naphthoate synthase activity', anchored to RHEA:42836 / EC 2.3.1.236. - subject_id: RHEA:36747 subject_label: "N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = beta-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase (wbbD Q03084, Escherichia coli; reviewed PE1, PMID:18536883; EC 2.4.1.303). No GO MF term exists for this reaction (QuickGO). PROPOSED NEW GO TERM: 'UDP-Gal:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-galactosyltransferase activity', anchored to RHEA:36747 / EC 2.4.1.303. # ===== Batch 4 (2026-06-20): mappings ranked by UniProtKB propagation gain ===== # Selected to maximise new UniProt annotations; reviews + gain in RHEA-MAPPING-REVIEWS.md / RHEA-ANNOTATION-GAIN.md. - subject_id: RHEA:48564 subject_label: "9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0102682 object_label: "cytokinin riboside 5'-monophosphate phosphoribohydrolase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG8 (LOG8 Q84MC2, Arabidopsis thaliana; reviewed PE1, catalytic activity PMID:19837870). EC-bridge: ec2go maps EC 3.2.2.n1 to GO:0102682 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~8,360 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:85243 subject_label: "2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0003960 object_label: "quinone reductase (NADPH) activity" mapping_justification: semapv:ManualMappingCuration comment: >- Zeta-crystallin (CRYZ Q08257, Homo sapiens; reviewed PE1, catalytic activity PMID:17497241). EC-bridge: ec2go maps EC 1.6.5.5 to GO:0003960 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~4,995 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:18113 subject_label: "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004550 object_label: "nucleoside diphosphate kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Adenylate kinase 7 (AK7 Q96M32, Homo sapiens; reviewed PE1, catalytic activity PMID:23416111). EC-bridge: ec2go maps EC 2.7.4.6 to GO:0004550 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~645 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:59468 subject_label: "an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0036374 object_label: "glutathione gamma-glutamate hydrolase" mapping_justification: semapv:ManualMappingCuration comment: >- Putative glutathione hydrolase 3 proenzyme (GGT3P A6NGU5, Homo sapiens; reviewed PE5, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.4.19.13 to GO:0036374 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~340 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:53428 subject_label: "a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0003908 object_label: "methylated-DNA-[protein]-cysteine S-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Methylated-DNA--protein-cysteine methyltransferase (MGMT P16455, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.1.1.63 to GO:0003908 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~200 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:63644 subject_label: "L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0046922 object_label: "peptide-O-fucosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- GDP-fucose protein O-fucosyltransferase 3 (POFUT3 Q6P4F1, Homo sapiens; reviewed PE1, catalytic activity PMID:39775168). EC-bridge: ec2go maps EC 2.4.1.221 to GO:0046922 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~186 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:44880 subject_label: "L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004675 object_label: "transmembrane receptor protein serine/threonine kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Activin receptor type-1B (ACVR1B P36896, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.7.11.30 to GO:0004675 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~183 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:77639 subject_label: "3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008441 object_label: "3'(2'),5'-bisphosphate nucleotidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 3' (BPNT1 O95861, Homo sapiens; reviewed PE1, catalytic activity PMID:10675562). EC-bridge: ec2go maps EC 3.1.3.7 to GO:0008441 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~167 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:47844 subject_label: "2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004789 object_label: "thiamine-phosphate diphosphorylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Thiamine-phosphate synthase (thiE P39594, Bacillus subtilis; reviewed PE1, catalytic activity PMID:9139923). EC-bridge: ec2go maps EC 2.5.1.3 to GO:0004789 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~151 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:54712 subject_label: "N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0071885 object_label: "N-terminal protein N-methyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1 Q9BV86, Homo sapiens; reviewed PE1, catalytic activity PMID:26543159). EC-bridge: ec2go maps EC 2.1.1.244 to GO:0071885 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~149 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:34287 subject_label: "2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004503 object_label: "tyrosinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Tyrosinase (TYR P14679, Homo sapiens; reviewed PE1, catalytic activity PMID:28661582). EC-bridge: ec2go maps EC 1.14.18.1 to GO:0004503 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~138 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:79699 subject_label: "1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008486 object_label: "diphosphoinositol-polyphosphate diphosphatase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Inositol diphosphatase DSP2 (DSP2 Q0DX67, Oryza sativa subsp. japonica; reviewed PE2, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.6.1.52 to GO:0008486 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~131 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:42288 subject_label: "6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008710 object_label: "8-amino-7-oxononanoate synthase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 8-amino-7-oxononanoate synthase (bioF P12998, Escherichia coli; reviewed PE1, catalytic activity PMID:20693992). EC-bridge: ec2go maps EC 2.3.1.47 to GO:0008710 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~86 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:65896 subject_label: "L-kynurenine + glyoxylate = kynurenate + glycine + H2O" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047315 object_label: "L-kynurenine:glyoxylate transaminase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Kynurenine--oxoglutarate transaminase 3 (KYAT3 Q6YP21, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.6.1.63 to GO:0047315 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~80 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:85579 subject_label: "alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004347 object_label: "glucose-6-phosphate isomerase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Glucose-6-phosphate isomerase (GPI P06744, Homo sapiens; reviewed PE1, catalytic activity PMID:28803808). EC-bridge: ec2go maps EC 5.3.1.9 to GO:0004347 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~80 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:27738 subject_label: "2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004731 object_label: "purine-nucleoside phosphorylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Purine nucleoside phosphorylase (PNP P00491, Homo sapiens; reviewed PE1, catalytic activity PMID:9305964). EC-bridge: ec2go maps EC 2.4.2.1 to GO:0004731 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~69 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:36231 subject_label: "a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004623 object_label: "A2-type glycerophospholipase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Cytosolic phospholipase A2 zeta (PLA2G4F Q68DD2, Homo sapiens; reviewed PE1, catalytic activity PMID:29158256). EC-bridge: ec2go maps EC 3.1.1.4 to GO:0004623 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~69 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:24768 subject_label: "7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0034256 object_label: "chlorophyll(ide) b reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Probable chlorophyll (NYC1 Q93ZA0, Arabidopsis thaliana; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.294 to GO:0034256 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~68 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:37339 subject_label: "3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+) + CO2" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0003837 object_label: "beta-ureidopropionase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Beta-ureidopropionase (UPB1 Q9UBR1, Homo sapiens; reviewed PE1, catalytic activity PMID:29976570). EC-bridge: ec2go maps EC 3.5.1.6 to GO:0003837 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~61 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:16541 subject_label: "9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0045549 object_label: "9-cis-epoxycarotenoid dioxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic (NCED3 Q9LRR7, Arabidopsis thaliana; reviewed PE1, catalytic activity PMID:15466233). EC-bridge: ec2go maps EC 1.13.11.51 to GO:0045549 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~49 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:25104 subject_label: "pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008478 object_label: "pyridoxal kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pyridoxal kinase (PDXK O00764, Homo sapiens; reviewed PE1, catalytic activity PMID:9099727). EC-bridge: ec2go maps EC 2.7.1.35 to GO:0008478 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~42 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:52540 subject_label: "cytidine + phosphate = cytosine + alpha-D-ribose 1-phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0016154 object_label: "pyrimidine-nucleoside phosphorylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Pyrimidine/purine nucleoside phosphorylase (ppnP P0C037, Escherichia coli; reviewed PE1, catalytic activity PMID:27941785). EC-bridge: ec2go maps EC 2.4.2.2 to GO:0016154 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~37 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:50496 subject_label: "N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004596 object_label: "protein-N-terminal amino-acid acetyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- N-alpha-acetyltransferase 10 (NAA10 P41227, Homo sapiens; reviewed PE1, catalytic activity PMID:25489052). EC-bridge: ec2go maps EC 2.3.1.255 to GO:0004596 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~32 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:51904 subject_label: "10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004326 object_label: "tetrahydrofolylpolyglutamate synthase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Dihydrofolate synthase/folylpolyglutamate synthase (folC P08192, Escherichia coli; reviewed PE1, catalytic activity PMID:2985605). EC-bridge: ec2go maps EC 6.3.2.17 to GO:0004326 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~29 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:64648 subject_label: "(E)-coniferaldehyde + NADP(+) + CoA = (E)-feruloyl-CoA + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0016621 object_label: "cinnamoyl-CoA reductase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Cinnamoyl-CoA reductase CAD2 (CAD2 G7IYC1, Medicago truncatula; reviewed PE1, catalytic activity PMID:25217505). EC-bridge: ec2go maps EC 1.2.1.44 to GO:0016621 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~27 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:33099 subject_label: "spermine + acetyl-CoA = N(1)-acetylspermine + CoA + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004145 object_label: "diamine N-acetyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Diamine acetyltransferase 1 (SAT1 P21673, Homo sapiens; reviewed PE1, catalytic activity PMID:17516632). EC-bridge: ec2go maps EC 2.3.1.57 to GO:0004145 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~19 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:25112 subject_label: "pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0033883 object_label: "pyridoxal phosphatase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Chronophin (PDXP Q96GD0, Homo sapiens; reviewed PE1, catalytic activity PMID:14522954). EC-bridge: ec2go maps EC 3.1.3.74 to GO:0033883 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~18 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:61392 subject_label: "N(6)-(D-psicosyl)-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] + ADP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0102193 object_label: "protein-ribulosamine 3-kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Fructosamine-3-kinase (FN3K Q9H479, Homo sapiens; reviewed PE1, catalytic activity PMID:11522682). EC-bridge: ec2go maps EC 2.7.1.172 to GO:0102193 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~14 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:75931 subject_label: "taurocyamine + H2O = urea + taurine" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047972 object_label: "guanidinopropionase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Guanidino acid hydrolase, mitochondrial (AGMAT Q9BSE5, Homo sapiens; reviewed PE1, catalytic activity PMID:36543883). EC-bridge: ec2go maps EC 3.5.3.17 to GO:0047972 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~13 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:43632 subject_label: "L-phenylalanyl-tRNA(Phe) + an N-terminal L-alpha-aminoacyl-[protein] = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008914 object_label: "leucyl-tRNA--protein transferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Leucyl/phenylalanyl-tRNA--protein transferase (aat P0A8P1, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.3.2.6 to GO:0008914 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~12 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:34495 subject_label: "(9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0016165 object_label: "linoleate 13S-lipoxygenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Lipoxygenase 7, chloroplastic (CM-LOX1 P38419, Oryza sativa subsp. japonica; reviewed PE2, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.13.11.12 to GO:0016165 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~11 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:58284 subject_label: "5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0017113 object_label: "dihydropyrimidine dehydrogenase (NADP+) activity" mapping_justification: semapv:ManualMappingCuration comment: >- Dihydropyrimidine dehydrogenase [NADP (DPYD Q12882, Homo sapiens; reviewed PE1, catalytic activity PMID:1512248). EC-bridge: ec2go maps EC 1.3.1.2 to GO:0017113 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~11 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:36179 subject_label: "1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + CMP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004142 object_label: "diacylglycerol cholinephosphotransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Choline/ethanolaminephosphotransferase 1 (CEPT1 Q9Y6K0, Homo sapiens; reviewed PE1, catalytic activity PMID:10191259). EC-bridge: ec2go maps EC 2.7.8.2 to GO:0004142 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~10 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:56552 subject_label: "L-threonyl-[rhodopsin] + ATP = O-phospho-L-threonyl-[rhodopsin] + ADP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050254 object_label: "rhodopsin kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Rhodopsin kinase GRK7 (GRK7 Q8WTQ7, Homo sapiens; reviewed PE1, catalytic activity PMID:15946941). EC-bridge: ec2go maps EC 2.7.11.14 to GO:0050254 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~10 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:62556 subject_label: "3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0043722 object_label: "4-hydroxyphenylacetate decarboxylase activity" mapping_justification: semapv:ManualMappingCuration comment: >- 4-hydroxyphenylacetate decarboxylase glycyl radical subunit (csdB Q38HX4, Clostridium scatologenes; reviewed PE1, catalytic activity PMID:16878993). EC-bridge: ec2go maps EC 4.1.1.83 to GO:0043722 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~7 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:59760 subject_label: "apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047891 object_label: "flavone 7-O-beta-glucosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Gallate 1-beta-glucosyltransferase 84A23 (UGT84A23 A0A193AUF6, Punica granatum; reviewed PE1, catalytic activity PMID:27227328). EC-bridge: ec2go maps EC 2.4.1.81 to GO:0047891 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~6 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:53900 subject_label: "L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004687 object_label: "myosin light chain kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Myosin light chain kinase 3 (MYLK3 Q32MK0, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.7.11.18 to GO:0004687 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~5 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:59980 subject_label: "8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0008413 object_label: "8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity" mapping_justification: semapv:ManualMappingCuration comment: >- ADP-sugar pyrophosphatase (NUDT5 Q9UKK9, Homo sapiens; reviewed PE1, catalytic activity PMID:27257257). EC-bridge: ec2go maps EC 3.6.1.69 to GO:0008413 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~4 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:65152 subject_label: "(2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + UDP + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047243 object_label: "flavanone 7-O-beta-glucosyltransferase activity" mapping_justification: semapv:ManualMappingCuration comment: >- UDP-glycosyltransferase 3A2 (UGT3A2 Q3SY77, Homo sapiens; reviewed PE1, catalytic activity PMID:21088224). EC-bridge: ec2go maps EC 2.4.1.185 to GO:0047243 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~2 UniProtKB entries carry the reaction but lack the term. - subject_id: RHEA:16457 subject_label: "(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0009027 object_label: "tartrate dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Probable tartrate dehydrogenase/decarboxylase (ycsA P42958, Bacillus subtilis; reviewed PE3, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.93 to GO:0009027 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~1 UniProtKB entries carry the reaction but lack the term. # ===== Batch 5 (2026-06-20): final EC-bridge mappings closing the Swiss-Prot gap ===== # After this, every cleanly EC-bridgeable RHEA reaction on a reviewed entry is covered (SP gain 0). - subject_id: RHEA:14321 subject_label: "morphine + NADP(+) = morphinone + NADPH + H(+)" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0050109 object_label: "morphine 6-dehydrogenase activity" mapping_justification: semapv:ManualMappingCuration comment: >- NADPH-dependent codeinone reductase 1-3 (COR1.3 Q9SQ68, Papaver somniferum; reviewed PE1, catalytic activity PMID:29779229). EC-bridge: ec2go maps EC 1.1.1.218 to GO:0050109 and rhea2ec maps this reaction to that EC. Closes the Swiss-Prot gap for this reaction (5 reviewed entries carry it but lack the term). - subject_id: RHEA:27682 subject_label: "dTDP + ATP = dTTP + ADP" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004550 object_label: "nucleoside diphosphate kinase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Nucleoside diphosphate kinase C (NME3 Q13232, Homo sapiens; reviewed PE1, catalytic activity PMID:11277919). EC-bridge: ec2go maps EC 2.7.4.6 to GO:0004550 and rhea2ec maps this reaction to that EC. Closes the Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term). - subject_id: RHEA:59352 subject_label: "beta-lactose + O2 = lactobiono-1,5-lactone + H2O2" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0047979 object_label: "hexose oxidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Hexose oxidase (HOX P93762, Chondrus crispus; reviewed PE1, catalytic activity PMID:9111074). EC-bridge: ec2go maps EC 1.1.3.5 to GO:0047979 and rhea2ec maps this reaction to that EC. Closes the Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term). - subject_id: RHEA:68796 subject_label: "D-maltose + H2O = alpha-D-glucose + D-glucose" predicate_id: skos:exactMatch predicate_label: exact match object_id: GO:0004575 object_label: "sucrose alpha-glucosidase activity" mapping_justification: semapv:ManualMappingCuration comment: >- Sucrase-isomaltase, intestinal (SI P14410, Homo sapiens; reviewed PE1, catalytic activity PMID:20356844). EC-bridge: ec2go maps EC 3.2.1.48 to GO:0004575 and rhea2ec maps this reaction to that EC. Closes the Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term). # ===== Batch 6 (2026-06-20): new GO term proposals (variant reactions GO lacks) ===== # Each reviewed enzyme carries a reaction with a Swiss-Prot gap and NO correct GO term; a sibling # GO term exists for a different cofactor/stereochemistry/substrate variant. Verified by definition. - subject_id: RHEA:28202 subject_label: "chlorophyllide a + oxidized 2[4Fe-4S]-[ferredoxin] + 2 ADP + 2 phosphate = protochlorophyllide a + reduced 2[4Fe-4S]-[ferredoxin] + 2 ATP + 2 H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Light-independent protochlorophyllide reductase subunit B (bchB P26163, Rhodobacter capsulatus; reviewed PE1, PMID:18358835; EC 1.3.7.7; ~327 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0016630 (NADPH/light-dependent POR); this is the light-independent (DPOR) ferredoxin-dependent enzyme). PROPOSED NEW GO TERM: 'ferredoxin-dependent protochlorophyllide reductase activity', defined by RHEA:28202 / EC 1.3.7.7. - subject_id: RHEA:26442 subject_label: "ethanol + a ubiquinone = a ubiquinol + acetaldehyde" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Alcohol dehydrogenase (adhB Q47945, Gluconobacter oxydans; reviewed PE1, PMID:9878716; EC 1.1.5.5; ~7 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; GO has other (quinone) dehydrogenases but not this; sibling GO:0004022 is the NAD(+) enzyme). PROPOSED NEW GO TERM: 'alcohol dehydrogenase (quinone) activity', defined by RHEA:26442 / EC 1.1.5.5. - subject_id: RHEA:27417 subject_label: "2 Fe(III)-[cytochrome] + nicotinate + H2O = 2 Fe(II)-[cytochrome] + 6-hydroxynicotinate + 2 H(+)" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Nicotinate dehydrogenase subunit B (nicB Q88FX8, Pseudomonas putida; reviewed PE1, PMID:18678916; EC 1.17.2.1; ~2 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0050138 is the NADP(+) enzyme; this uses cytochrome). PROPOSED NEW GO TERM: 'nicotinate dehydrogenase (cytochrome) activity', defined by RHEA:27417 / EC 1.17.2.1. - subject_id: RHEA:26522 subject_label: "(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- 2-methylcitrate dehydratase (acnD Q8EJW3, Shewanella oneidensis; reviewed PE1, PMID:14702315; EC 4.2.1.117; ~1 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0047547 forms the cis isomer (EC 4.2.1.79)). PROPOSED NEW GO TERM: '2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) activity', defined by RHEA:26522 / EC 4.2.1.117. - subject_id: RHEA:29595 subject_label: "sulfoacetaldehyde + NADP(+) + CoA = sulfoacetyl-CoA + NADPH + H(+)" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Sulfoacetaldehyde dehydrogenase (sauS Q0K845, Cupriavidus necator; reviewed PE1, PMID:20693281; EC 1.2.1.81; ~2 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; NADP-dependent acylating enzyme forming sulfoacetyl-CoA; sibling GO:0102984 is the NAD non-acylating enzyme). PROPOSED NEW GO TERM: 'sulfoacetaldehyde dehydrogenase (acylating) activity', defined by RHEA:29595 / EC 1.2.1.81. - subject_id: RHEA:27306 subject_label: "D-proline + A = 1-pyrroline-2-carboxylate + AH2" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- D-proline dehydrogenase (dpdh A1RVM8, Pyrobaculum islandicum; reviewed PE1, PMID:18558115; EC 1.5.99.13; ~1 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0004657 is L-proline dehydrogenase; GO:0050002 is D-proline reductase (different)). PROPOSED NEW GO TERM: 'D-proline dehydrogenase activity', defined by RHEA:27306 / EC 1.5.99.13. - subject_id: RHEA:26494 subject_label: "L-tryptophan + FADH2 + chloride + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Tryptophan 7-halogenase PrnA (prnA P95480, Pseudomonas fluorescens; reviewed PE1, PMID:9537395; EC 1.14.19.9; ~3 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; more specific than GO:0140907 flavin-dependent halogenase). PROPOSED NEW GO TERM: 'tryptophan 7-halogenase activity', defined by RHEA:26494 / EC 1.14.19.9. - subject_id: RHEA:18721 subject_label: "ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Ent-13-epi-manoyl oxide synthase KSL2, chloroplastic (KSL2 H6VLG5, Salvia miltiorrhiza; reviewed PE1, PMID:26077765; EC 4.2.3.186; ~1 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0062206 makes (13R)-manoyl oxide from a different substrate). PROPOSED NEW GO TERM: 'ent-13-epi-manoyl oxide synthase activity', defined by RHEA:18721 / EC 4.2.3.186. - subject_id: RHEA:30683 subject_label: "UDP-N-acetyl-alpha-D-glucosamine + H2O = aldehydo-N-acetyl-D-mannosamine + UDP + H(+)" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE Q9Y223, Homo sapiens; reviewed PE1, PMID:2808337; EC 3.2.1.183; ~1 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0008761 is the non-hydrolysing 2-epimerase). PROPOSED NEW GO TERM: 'UDP-N-acetylglucosamine 2-epimerase (hydrolysing) activity', defined by RHEA:30683 / EC 3.2.1.183. - subject_id: RHEA:31343 subject_label: "(2R)-2-O-(alpha-D-glucopyranosyl)-3-phospho-glycerate + H2O = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + phosphate" predicate_id: skos:exactMatch object_id: sssom:NoTermFound object_source: obo:go.owl mapping_justification: semapv:ManualMappingCuration comment: >- Glucosyl-3-phosphoglycerate/mannosyl-3-phosphoglycerate phosphatase (gpgP C0QRP9, Persephonella marina; reviewed PE1, PMID:17189358; EC 3.1.3.85; ~1 reviewed entries carry this reaction lacking a correct term). No correct GO MF term exists (QuickGO; sibling GO:0050531 is the mannosyl enzyme). PROPOSED NEW GO TERM: 'glucosyl-3-phosphoglycerate phosphatase activity', defined by RHEA:31343 / EC 3.1.3.85.