# GENERATED FILE - do not edit by hand.
# Source of truth: projects/RHEA/rhea2go.sssom.yaml
# Regenerate: uv run python projects/RHEA/sssom_to_terms.py projects/RHEA/rhea2go.sssom.yaml -o projects/RHEA/rhea2go.terms.yaml
# Validate:   uv run linkml-term-validator validate-data projects/RHEA/rhea2go.terms.yaml -s src/ai_gene_review/schema/rhea_go_mapping.yaml -t RHEAGOMappingSet --labels -c conf/oak_config.yaml
mappings:
- subject:
    id: RHEA:36079
    label: N-acylsphing-4-enine + 1,2-diacyl-sn-glycero-3-phosphoethanolamine = N-acylsphing-4-enine 1-phosphoethanolamine
      + 1,2-diacyl-sn-glycerol
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0002950
    label: ceramide phosphoethanolamine synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: The defining SMSr (SAMD8, Q96LT4) reaction. GO:0002950 already exists but is not on the protein
    and the reaction has no rhea2go row, so the activity fell through the cracks (gap class G6, pure propagation
    gap -- no new GO term needed). Cleanest case to add to rhea2go.
- subject:
    id: RHEA:13493
    label: (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate +
      NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004455
    label: ketol-acid reductoisomerase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'EC-bridge supported: rhea2ec maps RHEA:13493 to EC 1.1.1.86 and ec2go maps EC 1.1.1.86 to
    exactly GO:0004455; EC 1.1.1.86 has this single reaction, so RHEA -> GO is unambiguous. Branched-chain
    amino-acid biosynthesis (IlvC). Absent from rhea2go.'
- subject:
    id: RHEA:15333
    label: (S)-ureidoglycolate + NADP(+) = N-carbamoyl-2-oxoglycine + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0009040
    label: ureidoglycolate dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: EC-bridge supported via EC 1.1.1.154 -> GO:0009040 (single reaction for the EC). Purine/allantoin
    degradation. Absent from rhea2go.
- subject:
    id: RHEA:33751
    label: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)
      + phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008962
    label: phosphatidylglycerophosphatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: EC-bridge supported via EC 3.1.3.27 -> GO:0008962 (single reaction for the EC). Phosphatidylglycerol
    (membrane phospholipid) biosynthesis. Absent from rhea2go.
- subject:
    id: RHEA:64536
    label: N-(2R-hydroxy-VLCFA)-(R)-4-hydroxysphingoid base + 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)
      = inositol-phospho-ceramide + 1,2-diacyl-sn-glycerol
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0045140
    label: inositol phosphoceramide synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: EC-bridge supported via EC 2.7.1.227 -> GO:0045140 (single reaction for the EC). Fungal/plant
    sphingolipid biosynthesis (AUR1-type), the IPC-synthase analogue of the SMSr CPE case above. Absent
    from rhea2go.
- subject:
    id: RHEA:13733
    label: n-alkanal + NAD(+) = alk-2-enal + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0032440
    label: 2-alkenal reductase [NAD(P)H] activity
  mapping_justification: semapv:ManualMappingCuration
  comment: EC-bridge supported via EC 1.3.1.74 -> GO:0032440 (single reaction for the EC). RHEA reactions
    are direction-agnostic; the GO 'reductase' term and this RHEA equation describe the same conversion.
    Absent from rhea2go.
- subject:
    id: RHEA:34091
    label: (5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate
  predicate:
    id: skos:broadMatch
    label: broad match
  object:
    id: GO:0016829
    label: lyase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'PHYKPL (Q8IUZ5, EC 4.2.3.134). No GO term exists for this activity, and the EC is absent from
    ec2go, so the protein sits on the lyase root. PROPOSED NEW GO TERM: ''5-phosphooxy-L-lysine phospho-lyase
    activity'' (sibling of GO:0050459 ethanolamine-phosphate phospho-lyase activity), anchored to RHEA:34091
    / EC 4.2.3.134; once created, replace this broadMatch with an exactMatch.'
- subject:
    id: RHEA:37667
    label: GlcNAc-beta-1,4-Man-O-Thr-[protein] + UDP-N-acetyl-alpha-D-galactosamine = GalNAc-beta-1,3-GlcNAc-beta-1,4-Man-O-Thr-[protein]
      + UDP + H(+)
  predicate:
    id: skos:broadMatch
    label: broad match
  object:
    id: GO:0008376
    label: acetylgalactosaminyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'B3GALNT2 (Q8NCR0, EC 2.4.1.313), an alpha-dystroglycan O-mannosyl-glycan elongation enzyme
    (dystroglycanopathy MDDGA11). Only the generic class term exists. PROPOSED NEW GO TERM: ''N-acetyl-beta-glucosaminyl-glycoprotein
    beta-1,3-N-acetylgalactosaminyltransferase activity'' (child of GO:0008376), anchored to RHEA:37667
    / EC 2.4.1.313.'
- subject:
    id: RHEA:26422
    label: thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate +
      H(+)
  predicate:
    id: skos:broadMatch
    label: broad match
  object:
    id: GO:0004062
    label: aryl sulfotransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: SULT6B1 (Q6IMI4, thyroxine sulfotransferase). Thyroxine is an aryl (phenolic) substrate, so
    'aryl sulfotransferase activity' is a correct broader term and a defensible refinement of the bare
    'sulfotransferase activity' the protein currently carries. A substrate-specific 'thyroxine sulfotransferase
    activity' term would be exact, but the human enzyme's activity is annotated by similarity, so only
    the broader term is asserted here pending direct evidence.
- subject:
    id: RHEA:11536
    label: choline + 2 O2 + H2O = glycine betaine + 2 H2O2 + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0033713
    label: choline:oxygen 1-oxidoreductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Choline oxidase (codA Q7X2H8, Arthrobacter globiformis; reviewed PE1, catalytic activity PMID:12795615).
    EC-bridge: ec2go maps EC 1.1.3.17 to GO:0033713 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go.'
- subject:
    id: RHEA:28106
    label: galactitol 1-phosphate + NAD(+) = keto-D-tagatose 6-phosphate + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008868
    label: galactitol-1-phosphate 5-dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Galactitol 1-phosphate 5-dehydrogenase (gatD P0A9S3, Escherichia coli; reviewed PE1, catalytic
    activity PMID:13331868). EC-bridge: ec2go maps EC 1.1.1.251 to GO:0008868 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:37599
    label: (9Z,12Z)-hexadecadienoyl-CoA + AH2 + O2 = (9Z,12Z,15Z)-hexadecatrienoyl-CoA + A + 2 H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0102988
    label: acyl-CoA 15-desaturase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Fatty acid desaturase DES3 (DES3 Q594P3, Sorghum bicolor; reviewed PE1, catalytic activity
    PMID:17178719). EC-bridge: ec2go maps EC 1.14.19.13 to GO:0102988 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:41792
    label: holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004314
    label: '[acyl-carrier-protein] S-malonyltransferase activity'
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCAT Q8IVS2, Homo sapiens; reviewed
    PE1, catalytic activity PMID:19549604). EC-bridge: ec2go maps EC 2.3.1.39 to GO:0004314 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:42664
    label: alpha-L-arabinopyanose + NADP(+) = L-arabinono-1,4-lactone + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0044103
    label: L-arabinose 1-dehydrogenase (NADP+) activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'L-arabinose 1-dehydrogenase (xacB D4GP33, Haloferax volcanii; reviewed PE1, catalytic activity
    PMID:23949136). EC-bridge: ec2go maps EC 1.1.1.376 to GO:0044103 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:43620
    label: L-serine + NADP(+) = aminoacetaldehyde + CO2 + NADPH
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0031132
    label: serine 3-dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'NADP-dependent 3-hydroxy acid dehydrogenase YdfG (ydfG P39831, Escherichia coli; reviewed
    PE1, catalytic activity PMID:12535615). EC-bridge: ec2go maps EC 1.1.1.276 to GO:0031132 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:49072
    label: dibenzothiophene + 2 FMNH2 + 2 O2 = dibenzothiophene 5,5-dioxide + 2 FMN + 2 H2O + 2 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0018640
    label: dibenzothiophene monooxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Dibenzothiophene monooxygenase (dszC Q6WNP1, Rhodococcus erythropolis; reviewed PE1, catalytic
    activity PMID:24470304). EC-bridge: ec2go maps EC 1.14.14.21 to GO:0018640 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:67008
    label: a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end
      (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004482
    label: mRNA 5'-cap (guanine-N7-)-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'mRNA cap guanine-N (RNMT O43148, Homo sapiens; reviewed PE1, catalytic activity PMID:9790902).
    EC-bridge: ec2go maps EC 2.1.1.56 to GO:0004482 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go.'
- subject:
    id: RHEA:67012
    label: a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside
      in mRNA + diphosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004484
    label: mRNA guanylyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'mRNA-capping enzyme (RNGTT O60942, Homo sapiens; reviewed PE1, catalytic activity PMID:9473487).
    EC-bridge: ec2go maps EC 2.7.7.50 to GO:0004484 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go.'
- subject:
    id: RHEA:73067
    label: an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein]
      + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0033925
    label: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Cytosolic endo-beta-N-acetylglucosaminidase 1 (ENGASE1 F4JZC2, Arabidopsis thaliana; reviewed
    PE1, catalytic activity PMID:21796445). EC-bridge: ec2go maps EC 3.2.1.96 to GO:0033925 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:76995
    label: 2 reduced [4Fe-4S]-[ferredoxin] + NADP(+) + H(+) = 2 oxidized [4Fe-4S]-[ferredoxin] + NADPH
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004324
    label: ferredoxin-NADP+ reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Ferredoxin--NADP reductase A (- A9ES55, Sorangium cellulosum; reviewed PE1, catalytic activity
    PMID:19696019). EC-bridge: ec2go maps EC 1.18.1.2 to GO:0004324 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:77171
    label: biocytin + H2O = biotin + L-lysine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047708
    label: biotinidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Biotinidase (BTD P43251, Homo sapiens; reviewed PE1, catalytic activity PMID:9654207). EC-bridge:
    ec2go maps EC 3.5.1.12 to GO:0047708 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact.
    Absent from rhea2go.'
- subject:
    id: RHEA:10908
    label: glycolithocholate + 3'-phosphoadenylyl sulfate = glycolithocholate 3-sulfate + adenosine 3',5'-bisphosphate
      + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047704
    label: bile-salt sulfotransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Sulfotransferase 2A6 (Sult2a6 B2RVI8, Mus musculus; reviewed PE2, catalytic activity Swiss-Prot
    curator). EC-bridge: ec2go maps EC 2.8.2.14 to GO:0047704 and rhea2ec maps this reaction to that EC,
    so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:11440
    label: 2,3,5,6-tetrachlorophenol + NADPH + O2 = 2,3,5,6-tetrachlorohydroquinone + NADP(+) + H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0018677
    label: pentachlorophenol monooxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pentachlorophenol 4-monooxygenase (pcpB P42535, Sphingobium chlorophenolicum; reviewed PE1,
    catalytic activity PMID:25238136). EC-bridge: ec2go maps EC 1.14.13.50 to GO:0018677 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:11608
    label: '[N-acetyl-alpha-D-neuraminosyl-(2->8)](n) + n acetyl-CoA = [N,O(9)-diacetyl-alpha-D-neuraminosyl-(2->8)](n)
      + n CoA'
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050208
    label: polysialic-acid O-acetyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Polysialic acid O-acetyltransferase (neuO A1ADJ6, Escherichia coli O1:K1 / APEC; reviewed
    PE1, catalytic activity PMID:17519228). EC-bridge: ec2go maps EC 2.3.1.136 to GO:0050208 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:11640
    label: a (2R,3R)-flavan-3-ol + 2 NAD(+) = an anthocyanidin with a 3-hydroxy group + 2 NADH + 2 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0033729
    label: anthocyanidin reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Anthocyanidin reductase (BAN Q9SEV0, Arabidopsis thaliana; reviewed PE1, catalytic activity
    PMID:14725861). EC-bridge: ec2go maps EC 1.3.1.77 to GO:0033729 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:12500
    label: (3R)-1,4-thiomorpholine-3-carboxylate + NADP(+) = 3,4-dehydrothiomorpholine-3-carboxylate +
      NADPH + 2 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047127
    label: thiomorpholine-carboxylate dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Ketimine reductase mu-crystallin (CRYM Q14894, Homo sapiens; reviewed PE1, catalytic activity
    PMID:25931162). EC-bridge: ec2go maps EC 1.5.1.25 to GO:0047127 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:12609
    label: mercaptopurine + S-adenosyl-L-methionine = 6-methylthiopurine + S-adenosyl-L-homocysteine +
      H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008119
    label: thiopurine S-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Thiopurine S-methyltransferase (TPMT P51580, Homo sapiens; reviewed PE1, catalytic activity
    PMID:657528). EC-bridge: ec2go maps EC 2.1.1.67 to GO:0008119 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:12685
    label: 2 mycothiol + NADP(+) = mycothione + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050627
    label: mycothione reductase [NAD(P)H] activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Mycothione reductase (mtr P9WHH3, Mycobacterium tuberculosis; reviewed PE1, catalytic activity
    PMID:10512639). EC-bridge: ec2go maps EC 1.8.1.15 to GO:0050627 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:13817
    label: phylloquinone + [protein]-disulfide + H2O = 2,3-epoxyphylloquinone + [protein]-dithiol
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047057
    label: vitamin-K-epoxide reductase (warfarin-sensitive) activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1 Q8N0U8, Homo sapiens;
    reviewed PE1, catalytic activity PMID:24532791). EC-bridge: ec2go maps EC 1.17.4.4 to GO:0047057 and
    rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:14105
    label: L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004735
    label: pyrroline-5-carboxylate reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1 P32322, Homo sapiens; reviewed PE1,
    catalytic activity PMID:28258219). EC-bridge: ec2go maps EC 1.5.1.2 to GO:0004735 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:16573
    label: 4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004648
    label: O-phospho-L-serine:2-oxoglutarate transaminase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Phosphoserine aminotransferase (serC P23721, Escherichia coli; reviewed PE1, catalytic activity
    PMID:8706854). EC-bridge: ec2go maps EC 2.6.1.52 to GO:0004648 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:16905
    label: a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047408
    label: alkenylglycerophosphocholine hydrolase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Lysoplasmalogenase TMEM86A (TMEM86A Q8N2M4, Homo sapiens; reviewed PE1, catalytic activity
    PMID:36592658). EC-bridge: ec2go maps EC 3.3.2.2 to GO:0047408 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:18021
    label: a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E))
      + CMP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047288
    label: beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1 Q11201,
    Homo sapiens; reviewed PE1, catalytic activity PMID:8027041). EC-bridge: ec2go maps EC 2.4.3.2 to
    GO:0047288 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:16981
    label: 3-oxoadipate + NAD(+) = maleylacetate + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0018506
    label: maleylacetate reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Maleylacetate reductase 2 (tfdFII P94135, Cupriavidus pinatubonensis; reviewed PE1, catalytic
    activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.3.1.32 to GO:0018506 and rhea2ec maps this
    reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:14317
    label: morphine + NAD(+) = morphinone + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050109
    label: morphine 6-dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Aldo-keto reductase family 1 member C13 (AKR1C13 P82809, Mesocricetus auratus; reviewed PE1,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.218 to GO:0050109 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:48940
    label: an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid
  predicate:
    id: skos:broadMatch
    label: broad match
  object:
    id: GO:0016805
    label: dipeptidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: Dipeptidase 2 (DPEP2 Q9H4A9, Homo sapiens; reviewed PE1, PMID:32325220). EC 3.4.13.19. GO:0016805
    'dipeptidase activity' is a class term; a specific membrane-dipeptidase term would be exact. Reaction
    absent from rhea2go.
- subject:
    id: RHEA:30807
    label: L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050241
    label: pyrroline-2-carboxylate reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Ketimine reductase mu-crystallin (CRYM Q14894, Homo sapiens; reviewed PE1, catalytic activity
    PMID:25931162). EC-bridge: ec2go maps EC 1.5.1.1 to GO:0050241 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:17377
    label: a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein]
      + a di-trans,poly-cis-dolichyl phosphate + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004169
    label: dolichyl-phosphate-mannose-protein mannosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Protein O-mannosyl-transferase 2 (POMT2 Q9UKY4, Homo sapiens; reviewed PE1, catalytic activity
    PMID:28512129). EC-bridge: ec2go maps EC 2.4.1.109 to GO:0004169 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:17901
    label: xanthotoxol + S-adenosyl-L-methionine = xanthotoxin + S-adenosyl-L-homocysteine + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0030753
    label: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Esculetin O-methyltransferase (COMT-S A0A4P8DY91, Kitagawia praeruptora; reviewed PE1, catalytic
    activity PMID:30934718). EC-bridge: ec2go maps EC 2.1.1.70 to GO:0030753 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:18225
    label: '[N-(6-aminohexanoyl)](n) + H2O = [N-(6-aminohexanoyl)](n-1) + 6-aminohexanoate'
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0019875
    label: 6-aminohexanoate-dimer hydrolase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '6-aminohexanoate-dimer hydrolase (nylB P07061, Paenarthrobacter ureafaciens; reviewed PE1,
    catalytic activity PMID:6389532). EC-bridge: ec2go maps EC 3.5.1.46 to GO:0019875 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:20465
    label: '[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n)
      + UDP + H(+)'
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050501
    label: hyaluronan synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Hyaluronan synthase 1 (HAS1 Q92839, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot
    curator). EC-bridge: ec2go maps EC 2.4.1.212 to GO:0050501 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:20800
    label: 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
      + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
      + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047238
    label: glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Chondroitin sulfate synthase 3 (CHSY3 Q70JA7, Homo sapiens; reviewed PE1, catalytic activity
    PMID:12907687). EC-bridge: ec2go maps EC 2.4.1.175 to GO:0047238 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:21924
    label: 3-dehydro-L-gulonate + NAD(+) = 2,3-dioxo-L-gulonate + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047559
    label: 3-dehydro-L-gulonate 2-dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '2,3-diketo-L-gulonate reductase (dlgD P37672, Escherichia coli; reviewed PE1, catalytic activity
    Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.130 to GO:0047559 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:23048
    label: (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047988
    label: hydroxyacid-oxoacid transhydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1 Q8IWW8, Homo sapiens; reviewed
    PE1, catalytic activity PMID:16435184). EC-bridge: ec2go maps EC 1.1.99.24 to GO:0047988 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:23240
    label: (6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = N-formyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate
      + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0030409
    label: glutamate formimidoyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Formiminotransferase cyclodeaminase-like protein (FTCD-L Q9SKT4, Arabidopsis thaliana; reviewed
    PE2, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.1.2.5 to GO:0030409 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:23260
    label: (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate
      + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047034
    label: 15-hydroxyicosatetraenoate dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '15-hydroxyprostaglandin dehydrogenase [NAD (HPGD P15428, Homo sapiens; reviewed PE1, catalytic
    activity PMID:8086429). EC-bridge: ec2go maps EC 1.1.1.232 to GO:0047034 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:23428
    label: 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
      + UDP-alpha-D-glucuronate = 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]
      + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050510
    label: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Chondroitin sulfate synthase 3 (CHSY3 Q70JA7, Homo sapiens; reviewed PE1, catalytic activity
    PMID:12907687). EC-bridge: ec2go maps EC 2.4.1.226 to GO:0050510 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:23956
    label: L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein]
      + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004653
    label: polypeptide N-acetylgalactosaminyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10 Q86SR1, Homo sapiens; reviewed PE1,
    catalytic activity PMID:12417297). EC-bridge: ec2go maps EC 2.4.1.41 to GO:0004653 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:24670
    label: hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004854
    label: xanthine dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Xanthine dehydrogenase/oxidase (XDH P47989, Homo sapiens; reviewed PE1, catalytic activity
    PMID:8670112). EC-bridge: ec2go maps EC 1.17.1.4 to GO:0004854 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:24869
    label: 5'-deoxyadenosine + phosphate = 5-deoxy-alpha-D-ribose 1-phosphate + adenine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0017061
    label: S-methyl-5-thioadenosine phosphorylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'S-methyl-5''-thioadenosine phosphorylase (mtnP Q2RXH9, Rhodospirillum rubrum; reviewed PE1,
    catalytic activity PMID:31950558). EC-bridge: ec2go maps EC 2.4.2.28 to GO:0017061 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:25054
    label: (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate
      + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047070
    label: 3-carboxyethylcatechol 2,3-dioxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase (mhpB P0ABR9, Escherichia
    coli; reviewed PE1, catalytic activity PMID:8752345). EC-bridge: ec2go maps EC 1.13.11.16 to GO:0047070
    and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:25058
    label: (E)-cinnamate + NADH + O2 + H(+) = (2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate
      + NAD(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008695
    label: 3-phenylpropionate dioxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '3-phenylpropionate/cinnamic acid dioxygenase subunit beta (hcaF Q47140, Escherichia coli;
    reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.14.12.19 to GO:0008695
    and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:25173
    label: N(omega)-methyl-L-arginine + H2O = L-citrulline + methylamine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0016403
    label: dimethylargininase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'N (DDAH1 O94760, Homo sapiens; reviewed PE1, catalytic activity PMID:37296100). EC-bridge:
    ec2go maps EC 3.5.3.18 to GO:0016403 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact.
    Absent from rhea2go.'
- subject:
    id: RHEA:25193
    label: (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) = 3-methylcatechol + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0018504
    label: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Cis-toluene dihydrodiol dehydrogenase (todD P13859, Pseudomonas putida; reviewed PE1, catalytic
    activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.3.1.19 to GO:0018504 and rhea2ec maps this
    reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:25269
    label: (R)-noradrenaline + S-adenosyl-L-methionine = (R)-adrenaline + S-adenosyl-L-homocysteine +
      H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004603
    label: phenylethanolamine N-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Phenylethanolamine N-methyltransferase (PNMT P11086, Homo sapiens; reviewed PE1, catalytic
    activity PMID:8812853). EC-bridge: ec2go maps EC 2.1.1.28 to GO:0004603 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:26269
    label: Co-precorrin-2 + 3 H(+) = precorrin-2 + Co(2+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0016852
    label: sirohydrochlorin cobaltochelatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Sirohydrochlorin cobaltochelatase (cbiK Q05592, Salmonella typhimurium; reviewed PE1, catalytic
    activity PMID:9150215). EC-bridge: ec2go maps EC 4.99.1.3 to GO:0016852 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:27846
    label: (2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 + H(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate
      + NAD(+) + H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008688
    label: 3-(3-hydroxyphenyl)propionate hydroxylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '3- (mhpA P77397, Escherichia coli; reviewed PE1, catalytic activity Swiss-Prot curator). EC-bridge:
    ec2go maps EC 1.14.13.127 to GO:0008688 and rhea2ec maps this reaction to that EC, so RHEA->GO is
    exact. Absent from rhea2go.'
- subject:
    id: RHEA:28062
    label: alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid
      IVA (E. coli) + CMP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0043842
    label: Kdo transferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '3-deoxy-D-manno-octulosonic acid transferase (waaA P0AC75, Escherichia coli; reviewed PE1,
    catalytic activity PMID:1577828). EC-bridge: ec2go maps EC 2.4.99.13 to GO:0043842 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:28178
    label: (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate = colnelenate + H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0102895
    label: colneleate synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Divinyl ether synthase CYP74 (CYP74 Q2WE96, Allium sativum; reviewed PE1, catalytic activity
    PMID:9128734). EC-bridge: ec2go maps EC 4.2.1.121 to GO:0102895 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:28406
    label: XTP + H2O = XDP + phosphate + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0103023
    label: ITPase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Inosine/xanthosine triphosphatase (yjjX P39411, Escherichia coli; reviewed PE1, catalytic
    activity PMID:16216582). EC-bridge: ec2go maps EC 3.6.1.73 to GO:0103023 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:28418
    label: 4-(trimethylamino)butanoyl-CoA + (R)-carnitine = (R)-carnitinyl-CoA + 4-(trimethylamino)butanoate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008735
    label: L-carnitine CoA-transferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'L-carnitine CoA-transferase (caiB P31572, Escherichia coli; reviewed PE1, catalytic activity
    PMID:11551212). EC-bridge: ec2go maps EC 2.8.3.21 to GO:0008735 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:29859
    label: 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008782
    label: adenosylhomocysteine nucleosidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '5''-methylthioadenosine/S-adenosylhomocysteine nucleosidase (mtnN P0AF12, Escherichia coli;
    reviewed PE1, catalytic activity PMID:3911944). EC-bridge: ec2go maps EC 3.2.2.9 to GO:0008782 and
    rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:30367
    label: adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0043755
    label: alpha-ribazole phosphatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Adenosylcobalamin/alpha-ribazole phosphatase (cobC P52086, Escherichia coli; reviewed PE1,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.1.3.73 to GO:0043755 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:31375
    label: pyrrole-2-carboxylate + H(+) = 1H-pyrrole + CO2
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0034941
    label: pyrrole-2-carboxylate decarboxylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pyrrole-2-carboxylic acid decarboxylase (hudA Q9I6N5, Pseudomonas aeruginosa; reviewed PE1,
    catalytic activity PMID:33763291). EC-bridge: ec2go maps EC 4.1.1.93 to GO:0034941 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:31599
    label: thymine + FMNH2 + NADH + O2 = (Z)-2-methylureidoacrylate + FMN + NAD(+) + H2O + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0052614
    label: uracil oxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pyrimidine monooxygenase RutA (rutA P75898, Escherichia coli; reviewed PE1, catalytic activity
    PMID:28661684). EC-bridge: ec2go maps EC 1.14.99.46 to GO:0052614 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:31799
    label: 4-amino-5-aminomethyl-2-methylpyrimidine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine
      + NH4(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050334
    label: thiaminase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Aminopyrimidine aminohydrolase (tenA P25052, Bacillus subtilis; reviewed PE1, catalytic activity
    PMID:17618314). EC-bridge: ec2go maps EC 3.5.99.2 to GO:0050334 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:32951
    label: sucrose = trehalulose
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050006
    label: isomaltulose synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Isomaltulose synthase (palI Q8KR84, Klebsiella variicola; reviewed PE1, catalytic activity
    PMID:12039719). EC-bridge: ec2go maps EC 5.4.99.11 to GO:0050006 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:33507
    label: sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008117
    label: sphinganine-1-phosphate aldolase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Sphingosine-1-phosphate lyase 1 (SGPL1 O95470, Homo sapiens; reviewed PE1, catalytic activity
    PMID:28165339). EC-bridge: ec2go maps EC 4.1.2.27 to GO:0008117 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:33955
    label: DIBOA + UDP-alpha-D-glucose = DIBOA beta-D-glucoside + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047254
    label: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'DIMBOA UDP-glucosyltransferase BX9 (BX9 B4G072, Zea mays; reviewed PE1, catalytic activity
    PMID:16666853). EC-bridge: ec2go maps EC 2.4.1.202 to GO:0047254 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:33979
    label: DIBOA beta-D-glucoside + H2O = DIBOA + D-glucose
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0102726
    label: DIMBOA glucoside beta-D-glucosidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase
    1d, chloroplastic (GLU1D D5MTF8, Triticum aestivum; reviewed PE1, catalytic activity PMID:21875895).
    EC-bridge: ec2go maps EC 3.2.1.182 to GO:0102726 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go.'
- subject:
    id: RHEA:13969
    label: a 3'-end 3'-phospho-ribonucleotide-RNA + GTP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA
      + GMP + diphosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0003963
    label: RNA-3'-phosphate cyclase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'RNA 3''-terminal phosphate cyclase (rtc Q8U0N7, Pyrococcus furiosus; reviewed PE1, catalytic
    activity PMID:22074260). EC-bridge: ec2go maps EC 6.5.1.5 to GO:0003963 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go.'
- subject:
    id: RHEA:48564
    label: 9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0102682
    label: cytokinin riboside 5'-monophosphate phosphoribohydrolase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Cytokinin riboside 5''-monophosphate phosphoribohydrolase LOG8 (LOG8 Q84MC2, Arabidopsis thaliana;
    reviewed PE1, catalytic activity PMID:19837870). EC-bridge: ec2go maps EC 3.2.2.n1 to GO:0102682 and
    rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~8,360 UniProtKB
    entries carry the reaction but lack the term.'
- subject:
    id: RHEA:85243
    label: 2 1,2-naphthoquinone + NADPH + H(+) = 2 1,2-naphthosemiquinone + NADP(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0003960
    label: quinone reductase (NADPH) activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Zeta-crystallin (CRYZ Q08257, Homo sapiens; reviewed PE1, catalytic activity PMID:17497241).
    EC-bridge: ec2go maps EC 1.6.5.5 to GO:0003960 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~4,995 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:18113
    label: a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004550
    label: nucleoside diphosphate kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Adenylate kinase 7 (AK7 Q96M32, Homo sapiens; reviewed PE1, catalytic activity PMID:23416111).
    EC-bridge: ec2go maps EC 2.7.4.6 to GO:0004550 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~645 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:59468
    label: an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0036374
    label: glutathione gamma-glutamate hydrolase
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Putative glutathione hydrolase 3 proenzyme (GGT3P A6NGU5, Homo sapiens; reviewed PE5, catalytic
    activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.4.19.13 to GO:0036374 and rhea2ec maps this
    reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~340 UniProtKB entries carry the reaction
    but lack the term.'
- subject:
    id: RHEA:53428
    label: a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0003908
    label: methylated-DNA-[protein]-cysteine S-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Methylated-DNA--protein-cysteine methyltransferase (MGMT P16455, Homo sapiens; reviewed PE1,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.1.1.63 to GO:0003908 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~200 UniProtKB entries carry
    the reaction but lack the term.'
- subject:
    id: RHEA:63644
    label: L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0046922
    label: peptide-O-fucosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'GDP-fucose protein O-fucosyltransferase 3 (POFUT3 Q6P4F1, Homo sapiens; reviewed PE1, catalytic
    activity PMID:39775168). EC-bridge: ec2go maps EC 2.4.1.221 to GO:0046922 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~186 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:44880
    label: L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004675
    label: transmembrane receptor protein serine/threonine kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Activin receptor type-1B (ACVR1B P36896, Homo sapiens; reviewed PE1, catalytic activity Swiss-Prot
    curator). EC-bridge: ec2go maps EC 2.7.11.30 to GO:0004675 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go; ~183 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:77639
    label: 3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008441
    label: 3'(2'),5'-bisphosphate nucleotidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '3'' (BPNT1 O95861, Homo sapiens; reviewed PE1, catalytic activity PMID:10675562). EC-bridge:
    ec2go maps EC 3.1.3.7 to GO:0008441 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact.
    Absent from rhea2go; ~167 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:47844
    label: 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine
      + 2 H(+) = thiamine phosphate + CO2 + diphosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004789
    label: thiamine-phosphate diphosphorylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Thiamine-phosphate synthase (thiE P39594, Bacillus subtilis; reviewed PE1, catalytic activity
    PMID:9139923). EC-bridge: ec2go maps EC 2.5.1.3 to GO:0004789 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go; ~151 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:54712
    label: N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein]
      + 3 S-adenosyl-L-homocysteine + 3 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0071885
    label: N-terminal protein N-methyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1 Q9BV86, Homo sapiens; reviewed PE1, catalytic
    activity PMID:26543159). EC-bridge: ec2go maps EC 2.1.1.244 to GO:0071885 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~149 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:34287
    label: 2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004503
    label: tyrosinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Tyrosinase (TYR P14679, Homo sapiens; reviewed PE1, catalytic activity PMID:28661582). EC-bridge:
    ec2go maps EC 1.14.18.1 to GO:0004503 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact.
    Absent from rhea2go; ~138 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:79699
    label: 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol
      2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008486
    label: diphosphoinositol-polyphosphate diphosphatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Inositol diphosphatase DSP2 (DSP2 Q0DX67, Oryza sativa subsp. japonica; reviewed PE2, catalytic
    activity Swiss-Prot curator). EC-bridge: ec2go maps EC 3.6.1.52 to GO:0008486 and rhea2ec maps this
    reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~131 UniProtKB entries carry the reaction
    but lack the term.'
- subject:
    id: RHEA:42288
    label: 6-carboxyhexanoyl-[ACP] + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + holo-[ACP] + CO2
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008710
    label: 8-amino-7-oxononanoate synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '8-amino-7-oxononanoate synthase (bioF P12998, Escherichia coli; reviewed PE1, catalytic activity
    PMID:20693992). EC-bridge: ec2go maps EC 2.3.1.47 to GO:0008710 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go; ~86 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:65896
    label: L-kynurenine + glyoxylate = kynurenate + glycine + H2O
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047315
    label: L-kynurenine:glyoxylate transaminase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Kynurenine--oxoglutarate transaminase 3 (KYAT3 Q6YP21, Homo sapiens; reviewed PE1, catalytic
    activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.6.1.63 to GO:0047315 and rhea2ec maps this
    reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~80 UniProtKB entries carry the reaction
    but lack the term.'
- subject:
    id: RHEA:85579
    label: alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004347
    label: glucose-6-phosphate isomerase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Glucose-6-phosphate isomerase (GPI P06744, Homo sapiens; reviewed PE1, catalytic activity
    PMID:28803808). EC-bridge: ec2go maps EC 5.3.1.9 to GO:0004347 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go; ~80 UniProtKB entries carry the reaction but lack the
    term.'
- subject:
    id: RHEA:27738
    label: 2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004731
    label: purine-nucleoside phosphorylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Purine nucleoside phosphorylase (PNP P00491, Homo sapiens; reviewed PE1, catalytic activity
    PMID:9305964). EC-bridge: ec2go maps EC 2.4.2.1 to GO:0004731 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go; ~69 UniProtKB entries carry the reaction but lack the
    term.'
- subject:
    id: RHEA:36231
    label: a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine
      + a fatty acid + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004623
    label: A2-type glycerophospholipase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Cytosolic phospholipase A2 zeta (PLA2G4F Q68DD2, Homo sapiens; reviewed PE1, catalytic activity
    PMID:29158256). EC-bridge: ec2go maps EC 3.1.1.4 to GO:0004623 and rhea2ec maps this reaction to that
    EC, so RHEA->GO is exact. Absent from rhea2go; ~69 UniProtKB entries carry the reaction but lack the
    term.'
- subject:
    id: RHEA:24768
    label: 7(1)-hydroxychlorophyllide a + NAD(+) = chlorophyllide b + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0034256
    label: chlorophyll(ide) b reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Probable chlorophyll (NYC1 Q93ZA0, Arabidopsis thaliana; reviewed PE1, catalytic activity
    Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.294 to GO:0034256 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~68 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:37339
    label: 3-(carbamoylamino)-2-methylpropanoate + H2O + 2 H(+) = (R)-3-amino-2-methylpropanoate + NH4(+)
      + CO2
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0003837
    label: beta-ureidopropionase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Beta-ureidopropionase (UPB1 Q9UBR1, Homo sapiens; reviewed PE1, catalytic activity PMID:29976570).
    EC-bridge: ec2go maps EC 3.5.1.6 to GO:0003837 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~61 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:16541
    label: 9-cis-violaxanthin + O2 = (3S,5R,6S)-5,6-epoxy-3-hydroxy-5,6-dihydro-12'-apo-beta-caroten-12'-al
      + 2-cis,4-trans-xanthoxin
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0045549
    label: 9-cis-epoxycarotenoid dioxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic (NCED3 Q9LRR7, Arabidopsis thaliana;
    reviewed PE1, catalytic activity PMID:15466233). EC-bridge: ec2go maps EC 1.13.11.51 to GO:0045549
    and rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~49 UniProtKB
    entries carry the reaction but lack the term.'
- subject:
    id: RHEA:25104
    label: pyridoxamine + ATP = pyridoxamine 5'-phosphate + ADP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008478
    label: pyridoxal kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pyridoxal kinase (PDXK O00764, Homo sapiens; reviewed PE1, catalytic activity PMID:9099727).
    EC-bridge: ec2go maps EC 2.7.1.35 to GO:0008478 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~42 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:52540
    label: cytidine + phosphate = cytosine + alpha-D-ribose 1-phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0016154
    label: pyrimidine-nucleoside phosphorylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Pyrimidine/purine nucleoside phosphorylase (ppnP P0C037, Escherichia coli; reviewed PE1, catalytic
    activity PMID:27941785). EC-bridge: ec2go maps EC 2.4.2.2 to GO:0016154 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~37 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:50496
    label: N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA
      + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004596
    label: protein-N-terminal amino-acid acetyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'N-alpha-acetyltransferase 10 (NAA10 P41227, Homo sapiens; reviewed PE1, catalytic activity
    PMID:25489052). EC-bridge: ec2go maps EC 2.3.1.255 to GO:0004596 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go; ~32 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:51904
    label: 10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1)
      + ADP + phosphate + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004326
    label: tetrahydrofolylpolyglutamate synthase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Dihydrofolate synthase/folylpolyglutamate synthase (folC P08192, Escherichia coli; reviewed
    PE1, catalytic activity PMID:2985605). EC-bridge: ec2go maps EC 6.3.2.17 to GO:0004326 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~29 UniProtKB entries carry
    the reaction but lack the term.'
- subject:
    id: RHEA:64648
    label: (E)-coniferaldehyde + NADP(+) + CoA = (E)-feruloyl-CoA + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0016621
    label: cinnamoyl-CoA reductase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Cinnamoyl-CoA reductase CAD2 (CAD2 G7IYC1, Medicago truncatula; reviewed PE1, catalytic activity
    PMID:25217505). EC-bridge: ec2go maps EC 1.2.1.44 to GO:0016621 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go; ~27 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:33099
    label: spermine + acetyl-CoA = N(1)-acetylspermine + CoA + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004145
    label: diamine N-acetyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Diamine acetyltransferase 1 (SAT1 P21673, Homo sapiens; reviewed PE1, catalytic activity PMID:17516632).
    EC-bridge: ec2go maps EC 2.3.1.57 to GO:0004145 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~19 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:25112
    label: pyridoxine 5'-phosphate + H2O = pyridoxine + phosphate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0033883
    label: pyridoxal phosphatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Chronophin (PDXP Q96GD0, Homo sapiens; reviewed PE1, catalytic activity PMID:14522954). EC-bridge:
    ec2go maps EC 3.1.3.74 to GO:0033883 and rhea2ec maps this reaction to that EC, so RHEA->GO is exact.
    Absent from rhea2go; ~18 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:61392
    label: N(6)-(D-psicosyl)-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein]
      + ADP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0102193
    label: protein-ribulosamine 3-kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Fructosamine-3-kinase (FN3K Q9H479, Homo sapiens; reviewed PE1, catalytic activity PMID:11522682).
    EC-bridge: ec2go maps EC 2.7.1.172 to GO:0102193 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~14 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:75931
    label: taurocyamine + H2O = urea + taurine
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047972
    label: guanidinopropionase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Guanidino acid hydrolase, mitochondrial (AGMAT Q9BSE5, Homo sapiens; reviewed PE1, catalytic
    activity PMID:36543883). EC-bridge: ec2go maps EC 3.5.3.17 to GO:0047972 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~13 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:43632
    label: L-phenylalanyl-tRNA(Phe) + an N-terminal L-alpha-aminoacyl-[protein] = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein]
      + tRNA(Phe)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008914
    label: leucyl-tRNA--protein transferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Leucyl/phenylalanyl-tRNA--protein transferase (aat P0A8P1, Escherichia coli; reviewed PE1,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 2.3.2.6 to GO:0008914 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~12 UniProtKB entries carry
    the reaction but lack the term.'
- subject:
    id: RHEA:34495
    label: (9Z,12Z,15Z)-octadecatrienoate + O2 = (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0016165
    label: linoleate 13S-lipoxygenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Lipoxygenase 7, chloroplastic (CM-LOX1 P38419, Oryza sativa subsp. japonica; reviewed PE2,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.13.11.12 to GO:0016165 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~11 UniProtKB entries carry
    the reaction but lack the term.'
- subject:
    id: RHEA:58284
    label: 5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0017113
    label: dihydropyrimidine dehydrogenase (NADP+) activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Dihydropyrimidine dehydrogenase [NADP (DPYD Q12882, Homo sapiens; reviewed PE1, catalytic
    activity PMID:1512248). EC-bridge: ec2go maps EC 1.3.1.2 to GO:0017113 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~11 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:36179
    label: 1-O-alkyl-2-acyl-sn-glycerol + CDP-choline = a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine
      + CMP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004142
    label: diacylglycerol cholinephosphotransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Choline/ethanolaminephosphotransferase 1 (CEPT1 Q9Y6K0, Homo sapiens; reviewed PE1, catalytic
    activity PMID:10191259). EC-bridge: ec2go maps EC 2.7.8.2 to GO:0004142 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~10 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:56552
    label: L-threonyl-[rhodopsin] + ATP = O-phospho-L-threonyl-[rhodopsin] + ADP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050254
    label: rhodopsin kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Rhodopsin kinase GRK7 (GRK7 Q8WTQ7, Homo sapiens; reviewed PE1, catalytic activity PMID:15946941).
    EC-bridge: ec2go maps EC 2.7.11.14 to GO:0050254 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~10 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:62556
    label: 3,4-dihydroxyphenylacetate + H(+) = 4-methylcatechol + CO2
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0043722
    label: 4-hydroxyphenylacetate decarboxylase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: '4-hydroxyphenylacetate decarboxylase glycyl radical subunit (csdB Q38HX4, Clostridium scatologenes;
    reviewed PE1, catalytic activity PMID:16878993). EC-bridge: ec2go maps EC 4.1.1.83 to GO:0043722 and
    rhea2ec maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~7 UniProtKB entries
    carry the reaction but lack the term.'
- subject:
    id: RHEA:59760
    label: apigenin + UDP-alpha-D-glucose = apigenin 7-O-beta-D-glucoside + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047891
    label: flavone 7-O-beta-glucosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Gallate 1-beta-glucosyltransferase 84A23 (UGT84A23 A0A193AUF6, Punica granatum; reviewed PE1,
    catalytic activity PMID:27227328). EC-bridge: ec2go maps EC 2.4.1.81 to GO:0047891 and rhea2ec maps
    this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~6 UniProtKB entries carry the
    reaction but lack the term.'
- subject:
    id: RHEA:53900
    label: L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004687
    label: myosin light chain kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Myosin light chain kinase 3 (MYLK3 Q32MK0, Homo sapiens; reviewed PE1, catalytic activity
    Swiss-Prot curator). EC-bridge: ec2go maps EC 2.7.11.18 to GO:0004687 and rhea2ec maps this reaction
    to that EC, so RHEA->GO is exact. Absent from rhea2go; ~5 UniProtKB entries carry the reaction but
    lack the term.'
- subject:
    id: RHEA:59980
    label: 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0008413
    label: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'ADP-sugar pyrophosphatase (NUDT5 Q9UKK9, Homo sapiens; reviewed PE1, catalytic activity PMID:27257257).
    EC-bridge: ec2go maps EC 3.6.1.69 to GO:0008413 and rhea2ec maps this reaction to that EC, so RHEA->GO
    is exact. Absent from rhea2go; ~4 UniProtKB entries carry the reaction but lack the term.'
- subject:
    id: RHEA:65152
    label: (2S)-naringenin + UDP-alpha-D-glucose = (2S)-naringenin 7-O-beta-D-glucoside + UDP + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047243
    label: flavanone 7-O-beta-glucosyltransferase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'UDP-glycosyltransferase 3A2 (UGT3A2 Q3SY77, Homo sapiens; reviewed PE1, catalytic activity
    PMID:21088224). EC-bridge: ec2go maps EC 2.4.1.185 to GO:0047243 and rhea2ec maps this reaction to
    that EC, so RHEA->GO is exact. Absent from rhea2go; ~2 UniProtKB entries carry the reaction but lack
    the term.'
- subject:
    id: RHEA:16457
    label: (2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0009027
    label: tartrate dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Probable tartrate dehydrogenase/decarboxylase (ycsA P42958, Bacillus subtilis; reviewed PE3,
    catalytic activity Swiss-Prot curator). EC-bridge: ec2go maps EC 1.1.1.93 to GO:0009027 and rhea2ec
    maps this reaction to that EC, so RHEA->GO is exact. Absent from rhea2go; ~1 UniProtKB entries carry
    the reaction but lack the term.'
- subject:
    id: RHEA:14321
    label: morphine + NADP(+) = morphinone + NADPH + H(+)
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0050109
    label: morphine 6-dehydrogenase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'NADPH-dependent codeinone reductase 1-3 (COR1.3 Q9SQ68, Papaver somniferum; reviewed PE1,
    catalytic activity PMID:29779229). EC-bridge: ec2go maps EC 1.1.1.218 to GO:0050109 and rhea2ec maps
    this reaction to that EC. Closes the Swiss-Prot gap for this reaction (5 reviewed entries carry it
    but lack the term).'
- subject:
    id: RHEA:27682
    label: dTDP + ATP = dTTP + ADP
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004550
    label: nucleoside diphosphate kinase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Nucleoside diphosphate kinase C (NME3 Q13232, Homo sapiens; reviewed PE1, catalytic activity
    PMID:11277919). EC-bridge: ec2go maps EC 2.7.4.6 to GO:0004550 and rhea2ec maps this reaction to that
    EC. Closes the Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term).'
- subject:
    id: RHEA:59352
    label: beta-lactose + O2 = lactobiono-1,5-lactone + H2O2
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0047979
    label: hexose oxidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Hexose oxidase (HOX P93762, Chondrus crispus; reviewed PE1, catalytic activity PMID:9111074).
    EC-bridge: ec2go maps EC 1.1.3.5 to GO:0047979 and rhea2ec maps this reaction to that EC. Closes the
    Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term).'
- subject:
    id: RHEA:68796
    label: D-maltose + H2O = alpha-D-glucose + D-glucose
  predicate:
    id: skos:exactMatch
    label: exact match
  object:
    id: GO:0004575
    label: sucrose alpha-glucosidase activity
  mapping_justification: semapv:ManualMappingCuration
  comment: 'Sucrase-isomaltase, intestinal (SI P14410, Homo sapiens; reviewed PE1, catalytic activity
    PMID:20356844). EC-bridge: ec2go maps EC 3.2.1.48 to GO:0004575 and rhea2ec maps this reaction to
    that EC. Closes the Swiss-Prot gap for this reaction (1 reviewed entries carry it but lack the term).'