Stress granules

Assembly and disassembly of stress-induced RNA-protein condensates in human: a scoped project

AI Gene Review · projects/STRESS_GRANULES · SCOPING · 2026

Bottom line

  • Scoped, not started. No stress granule module; the core nucleators G3BP1 and G3BP2 are not reviewed.
  • 6 of 16 listed candidates already have reviews made for other projects (TIA1, TIAL1, USP10, TARDBP, HNRNPA2B1, VCP).
  • In those, stress-granule rows were accepted for TIA1, TIAL1, TARDBP and VCP; USP10's negative-regulation rows are non-core.

The biology

Why this is worth doing

  • Stress granules are the best-known cytoplasmic condensate, and several ALS/FTD proteins (TDP-43, FUS, hnRNPA1/A2B1, ATXN2) partition into them.
  • Many RNA-binding proteins are found in granules; few build them. Separating nucleators from residents is the key curation call.
  • The general question of how GO should represent condensates is handled in CONDENSATES.

Where the candidate genes stand

Next steps

  1. just fetch-gene human G3BP1 and G3BP2; review them, then CAPRIN1.
  2. Review FUS, HNRNPA1, ATXN2, FMR1, PABPC1, EIF2S1 and EIF4G1.
  3. Build a stress granule module distinguishing nucleators, regulators, residents and disassembly factors.

Read more: projects/STRESS_GRANULES.md · genes/human/TIA1/ · projects/CONDENSATES.md