Sulfide oxidation children obsoletion

GO:0070221 · GO:0070222 · GO:0070223 → GO:0019418 sulfide oxidation

AI Gene Review · projects/SULFIDE_OXIDATION_OBSOLETION · 2026

Bottom line

  • GO obsoleted three enzyme-specific children of sulfide oxidation; all three ontology PRs are merged.
  • Only GO:0070221 (via SQOR) had annotations: human SQOR (IDA), TSTD1 (TAS), SLC25A10 (TAS), plus rodent Sqor ISO/ISS.
  • Partly done: SLC25A10 is now reviewed (row on GO:0019418, over-annotated); SQOR and TSTD1 are unreviewed.

Three children collapse into the parent

Why the children went

  • Each child named the enzyme that does the oxidation, which is more specific than any gene product needs.
  • GO:0070222 and GO:0070223 had zero direct annotations.
  • The mechanism stays expressible through the MF, e.g. GO:0047804 sulfide:quinone reductase activity.
  • Upstream cleanup: InterPro dropped IPR042457 → GO:0070221; Reactome migrated its 2 rows; IBA rows follow PAINT.

Who does the oxidising

State in this repo

Gene Row on obsolete term Review here
SQOR (Q9Y6N5) IDA + IBA none
TSTD1 (Q8NFU3) TAS + IEA none
SLC25A10 (Q9UBX3) now TAS on GO:0019418 (Reactome) genes/human/SLC25A10: MARK_AS_OVER_ANNOTATED

SLC25A10 was reviewed in the mitochondrial carrier work (#2093), after this page was written. The carrier exchanges sulfate and thiosulfate for phosphate; it does not oxidise sulfide.

Next steps

  1. just fetch-gene human SQOR: anchor MF on GO:0047804 and BP on GO:0019418; SQOR deficiency makes it clinically relevant.
  2. Then TSTD1: is GO:0019418 right for a thiosulfate sulfurtransferase, or was the TAS weak?
  3. Leave S. pombe hmt2 and bacterial homologs to IBA remapping.

Upstream: go-annotation#6388 (open) · go-ontology#31842 (closed) · PRs #31949, #32025, #32068 (merged)
Read more: projects/SULFIDE_OXIDATION_OBSOLETION.md