Regulation of synaptic vesicle docking obsoletion

GO:0099148 retired as docking becomes a molecular function, GO:0160321

AI Gene Review · projects/SYNAPTIC_VESICLE_DOCKING_OBSOLETION · 2026

Bottom line

  • GO now treats vesicle docking as a molecular function (GO:0160321); GO:0099148 regulation of synaptic vesicle docking is obsolete.
  • Its SynGO rows sit on Camk2a, Septin5 and tom-1; a regulator should not inherit the docking MF.
  • Camk2a fixed in #3237 (merged): both GO:0099148 rows → MODIFY to GO:0048172 regulation of short-term neuronal synaptic plasticity, not the docking MF.

Where this term sits in the vesicle refactor

Why docking became a function

  • Upstream reason: the term "represents a molecular function", the binding activity of a docking protein.
  • GO:0160321 is defined as binding that stably attaches a vesicle to its target membrane; it sits after tethering (GO:7770062) and before fusion.
  • A regulation of process has no 1:1 MF counterpart, so each gene needs its own decision.
  • Upstream spreadsheet: SynGO's 8 rows on GO:0099148, plus about 60 IEA ortholog rows that follow automatically.

Regulator or docker?

State in this repo

Gene Rows on GO:0099148 Review here
Camk2a (mouse P11798) IMP + IDA, PMID:17660813 ACCEPT → MODIFY GO:0048172 (#3237, merged)
Septin5 (mouse Q9Z2Q6) IMP + IDA, PMID:20624595 none
tom-1 (worm A0A0K3ATN9) IMP ×2 + IDA ×2, PMID:16895441 none

Rat Camk2a and Septin5 carry ISO copies (RGD). #3237 also replaced the tangential Camk2a supporting text with the abstract's sentences on docked-vesicle number and short-term presynaptic plasticity.

Next steps

  1. #3237 merged (Camk2a → GO:0048172).
  2. Review Septin5 (then human SEPTIN5, Q99719): the one candidate for GO:0160321.
  3. Review tom-1 as the negative-regulator case.

Siblings: VESICLE_DOCKING_OBSOLETION (parent, #6379) · VESICLE_TETHERING_OBSOLETION (#6375) · VESICLE_TARGETING_OBSOLETION (#6424)

Upstream: go-annotation#6415 · go-ontology#31880