gene term_id term_label aspect action file family graft graft_an status term_in_current_tg_set ibd ibd_an steps_from_ibd ibd_event ibd_taxon ibd_clade query_in_ibd_clade ibd_is_root duplication_on_path ibd_leaves n_seeds seeds TAS1R1 GO:0050917 sensory perception of umami taste biological_process KEEP_AS_NON_CORE genes/9AVES/TAS1R1/TAS1R1-ai-review.yaml PTHR24061 PTN009077744 AN91 ok True PTN000625160 AN64 2 SPECIATION Amniota Amniota True False False 17 2 RGD:61891|UniProtKB:Q7RTX1 TAS1R3 GO:0033041 sweet taste receptor activity molecular_function ACCEPT genes/9AVES/TAS1R3/TAS1R3-ai-review.yaml PTHR24061 PTN009078551 AN1438 ok True PTN000626098 AN1405 2 SPECIATION Amniota Amniota True False False 18 1 UniProtKB:Q7RTX0 TAS1R3 GO:0050916 sensory perception of sweet taste biological_process ACCEPT genes/9AVES/TAS1R3/TAS1R3-ai-review.yaml PTHR24061 PTN009078551 AN1438 ok True PTN002781362 AN1404 3 SPECIATION Euteleostomi Euteleostomi True False False 21 3 MGI:MGI:1933547|UniProtKB:Q7RTX0|RGD:620539 TAS1R3 GO:0050917 sensory perception of umami taste biological_process KEEP_AS_NON_CORE genes/9AVES/TAS1R3/TAS1R3-ai-review.yaml PTHR24061 PTN009078551 AN1438 ok True PTN002781362 AN1404 3 SPECIATION Euteleostomi Euteleostomi True False False 21 2 UniProtKB:Q7RTX0|RGD:620539 NCGR_LOCUS10166 GO:0005737 cytoplasm cellular_component ACCEPT genes/9POAL/NCGR_LOCUS10166/NCGR_LOCUS10166-ai-review.yaml PTHR21256 no_graft_node NCGR_LOCUS10166 GO:0005829 cytosol cellular_component UNDECIDED genes/9POAL/NCGR_LOCUS10166/NCGR_LOCUS10166-ai-review.yaml PTHR21256 no_graft_node NCGR_LOCUS10166 GO:0009570 chloroplast stroma cellular_component UNDECIDED genes/9POAL/NCGR_LOCUS10166/NCGR_LOCUS10166-ai-review.yaml PTHR21256 no_graft_node NCGR_LOCUS1270 GO:0005737 cytoplasm cellular_component ACCEPT genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 ok True PTN000168022 AN0 20 SPECIATION LUCA LUCA True True True 377 9 UniProtKB:O97193|UniProtKB:Q38EA4|SGD:S000004369|UniProtKB:O00757|AGI_LocusCode:AT1G43670|UniProtKB:P09467|UniProtKB:P0A993|UniProtKB:Q586C9|AGI_LocusCode:AT3G54050 NCGR_LOCUS1270 GO:0005829 cytosol cellular_component UNDECIDED genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 ok True PTN000168034 AN124 17 SPECIATION Eukaryota Eukaryota True False True 296 2 UniProtKB:O00757|SGD:S000004369 NCGR_LOCUS1270 GO:0005986 sucrose biosynthetic process biological_process UNDECIDED genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 no_same_term_ibd_on_path False NCGR_LOCUS1270 GO:0006000 fructose metabolic process biological_process UNDECIDED genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 no_same_term_ibd_on_path False NCGR_LOCUS1270 GO:0006002 fructose 6-phosphate metabolic process biological_process ACCEPT genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 no_same_term_ibd_on_path False NCGR_LOCUS1270 GO:0006094 gluconeogenesis biological_process UNDECIDED genes/9POAL/NCGR_LOCUS1270/NCGR_LOCUS1270-ai-review.yaml PTHR11556 PTN004269459 AN397 ok True PTN000168022 AN0 20 SPECIATION LUCA LUCA True True True 377 8 RGD:2595|MGI:MGI:95492|SGD:S000004369|UniProtKB:O97193|UniProtKB:P0A993|RGD:620930|UniProtKB:P09467|CGD:CAL0000200348 NCGR_LOCUS1765 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay biological_process ACCEPT genes/9POAL/NCGR_LOCUS1765/NCGR_LOCUS1765-ai-review.yaml PTHR12412 PTN004359638 AN124 ok True PTN000275634 AN0 12 SPECIATION Eukaryota Eukaryota True True False 100 2 UniProtKB:Q09161|SGD:S000004732 NCGR_LOCUS1765 GO:0003729 mRNA binding molecular_function ACCEPT genes/9POAL/NCGR_LOCUS1765/NCGR_LOCUS1765-ai-review.yaml PTHR12412 PTN004359638 AN124 ok True PTN000275634 AN0 12 SPECIATION Eukaryota Eukaryota True True False 100 1 SGD:S000004732 NCGR_LOCUS27674 GO:0005504 fatty acid binding molecular_function REMOVE genes/9POAL/NCGR_LOCUS27674/NCGR_LOCUS27674-ai-review.yaml PTHR47284 PTN009208978 AN58 ok True PTN001998028 AN28 10 SPECIATION Embryophyta Embryophyta True False True 63 1 AGI_LocusCode:AT2G26310 NCGR_LOCUS27674 GO:0009570 chloroplast stroma cellular_component UNDECIDED genes/9POAL/NCGR_LOCUS27674/NCGR_LOCUS27674-ai-review.yaml PTHR47284 PTN009208978 AN58 ok True PTN001998028 AN28 10 SPECIATION Embryophyta Embryophyta True False True 63 1 AGI_LocusCode:AT2G26310 NCGR_LOCUS29329 GO:0009067 aspartate family amino acid biosynthetic process biological_process ACCEPT genes/9POAL/NCGR_LOCUS29329/NCGR_LOCUS29329-ai-review.yaml PTHR43070 PTN009166675 AN178 ok True PTN000487079 AN100 15 SPECIATION Eukaryota Eukaryota True False True 97 3 CGD:CAL0000188452|SGD:S000003900|AGI_LocusCode:AT1G31230 NCGR_LOCUS29329 GO:0009090 L-homoserine biosynthetic process biological_process ACCEPT genes/9POAL/NCGR_LOCUS29329/NCGR_LOCUS29329-ai-review.yaml PTHR43070 PTN009166675 AN178 ok True PTN000487079 AN100 15 SPECIATION Eukaryota Eukaryota True False True 97 2 SGD:S000003900|CGD:CAL0000188452 NCGR_LOCUS67308 GO:0005739 mitochondrion cellular_component ACCEPT genes/9POAL/NCGR_LOCUS67308/NCGR_LOCUS67308-ai-review.yaml PTHR11921 PTN002629819 AN278 ok True PTN001376708 AN190 8 SPECIATION Embryophyta Embryophyta True False True 117 3 AGI_LocusCode:AT5G40650|AGI_LocusCode:AT5G65165|AGI_LocusCode:AT3G27380 NCGR_LOCUS67308 GO:0009060 aerobic respiration biological_process ACCEPT genes/9POAL/NCGR_LOCUS67308/NCGR_LOCUS67308-ai-review.yaml PTHR11921 PTN002629819 AN278 ok True PTN000229864 AN0 20 SPECIATION LUCA LUCA True True True 224 5 FB:FBgn0014028|MGI:MGI:1914930|ZFIN:ZDB-GENE-030131-8005|SGD:S000003964|UniProtKB:P07014 NCGR_LOCUS67308 GO:0022904 respiratory electron transport chain biological_process ACCEPT genes/9POAL/NCGR_LOCUS67308/NCGR_LOCUS67308-ai-review.yaml PTHR11921 PTN002629819 AN278 ok True PTN000229864 AN0 20 SPECIATION LUCA LUCA True True True 224 4 RGD:1308598|FB:FBgn0014028|ZFIN:ZDB-GENE-030131-8005|SGD:S000003964 OLFML2A GO:0007165 signal transduction biological_process MARK_AS_OVER_ANNOTATED genes/9PRIM/A0A8C9H4D2/A0A8C9H4D2-ai-review.yaml PTHR23192 PTN000573914 AN229 ok True PTN000573635 AN0 13 SPECIATION Bilateria Bilateria True True True 287 3 UniProtKB:Q99972|MGI:MGI:1860437|MGI:MGI:1202864 celX GO:0004622 phosphatidylcholine lysophospholipase A1 activity molecular_function MODIFY genes/ACET2/P15329/P15329-ai-review.yaml PTHR30383 PTN002411393 AN16 no_same_term_ibd_on_path False xghA GO:0010411 xyloglucan metabolic process biological_process ACCEPT genes/ACET2/Q70DK5/Q70DK5-ai-review.yaml PTHR43739 PTN005180743 AN11 ok True PTN001286313 AN0 2 SPECIATION Eubacteria Eubacteria True True True 14 1 UniProtKB:Q5BD38 celC GO:0005576 extracellular region cellular_component ACCEPT genes/ACET2/celC/celC-ai-review.yaml PTHR31297 PTN001262731 AN170 no_same_term_ibd_on_path False celC GO:0008422 beta-glucosidase activity molecular_function REMOVE genes/ACET2/celC/celC-ai-review.yaml PTHR31297 PTN001262731 AN170 no_same_term_ibd_on_path False celC GO:0009251 glucan catabolic process biological_process ACCEPT genes/ACET2/celC/celC-ai-review.yaml PTHR31297 PTN001262731 AN170 ok True PTN001262628 AN0 1 SPECIATION LUCA LUCA True True False 108 2 UniProtKB:Q5AVZ7|UniProtKB:Q5B6Q3 celC GO:0009986 cell surface cellular_component REMOVE genes/ACET2/celC/celC-ai-review.yaml PTHR31297 PTN001262731 AN170 no_same_term_ibd_on_path False ermA GO:0005829 cytosol cellular_component ACCEPT genes/AERER/ermA/ermA-ai-review.yaml PTHR11727 PTN000197986 AN600 ok True PTN000197981 AN594 5 SPECIATION Eubacteria Eubacteria True False True 37 1 UniProtKB:P06992 ermA GO:0031167 rRNA methylation biological_process ACCEPT genes/AERER/ermA/ermA-ai-review.yaml PTHR11727 PTN000197986 AN600 ok True PTN000197843 AN0 7 SPECIATION LUCA LUCA True True True 341 4 UniProtKB:Q8WVM0|MGI:MGI:2146851|UniProtKB:P06992|UniProtKB:Q9UNQ2 mcr-3 GO:0009244 lipopolysaccharide core region biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/AERME/mcr-3/mcr-3-ai-review.yaml PTHR30443 PTN002019542 AN24 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 mcr-3 GO:0016776 phosphotransferase activity, phosphate group as acceptor molecular_function MODIFY genes/AERME/mcr-3/mcr-3-ai-review.yaml PTHR30443 PTN002019542 AN24 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 fibrolase GO:0005886 plasma membrane cellular_component REMOVE genes/AGKCO/fibrolase/fibrolase-ai-review.yaml PTHR11905 PTN002628616 AN634 ok True PTN002628616 AN634 0 SPECIATION Euteleostomi Euteleostomi True False False 55 3 MGI:MGI:105988|UniProtKB:Q9UKQ2|MGI:MGI:107247 tigA GO:0006457 protein folding biological_process ACCEPT genes/ASPNG/tigA/tigA-ai-review.yaml PTHR45672 PTN002903521 AN312 ok True PTN005231188 AN0 9 DUPLICATION True True 276 3 UniProtKB:Q14554|PomBase:SPAC17H9.14c|SGD:S000005448 fogD GO:0000140 acylglycerone-phosphate reductase (NADP+) activity molecular_function MODIFY genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001963740 AN10 9 SPECIATION Unikonts Unikonts True False True 27 1 SGD:S000001386 fogD GO:0004806 triacylglycerol lipase activity molecular_function MARK_AS_OVER_ANNOTATED genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001963740 AN10 9 SPECIATION Unikonts Unikonts True False True 27 1 SGD:S000001386 fogD GO:0005783 endoplasmic reticulum cellular_component KEEP_AS_NON_CORE genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001213826 AN9 10 SPECIATION Eukaryota Eukaryota True False True 118 1 SGD:S000001386 fogD GO:0005811 lipid droplet cellular_component KEEP_AS_NON_CORE genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001963740 AN10 9 SPECIATION Unikonts Unikonts True False True 27 1 SGD:S000001386 fogD GO:0006654 phosphatidic acid biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001963740 AN10 9 SPECIATION Unikonts Unikonts True False True 27 1 SGD:S000001386 fogD GO:0019433 triglyceride catabolic process biological_process MARK_AS_OVER_ANNOTATED genes/ASPRC/fogD/fogD-ai-review.yaml PTHR44169 PTN001211783 AN34 ok True PTN001963740 AN10 9 SPECIATION Unikonts Unikonts True False True 27 1 SGD:S000001386 ermJ GO:0031167 rRNA methylation biological_process ACCEPT genes/BACAN/ermJ/ermJ-ai-review.yaml PTHR11727 PTN000919750 AN585 ok True PTN000197843 AN0 1 SPECIATION LUCA LUCA True True False 341 4 UniProtKB:Q8WVM0|MGI:MGI:2146851|UniProtKB:P06992|UniProtKB:Q9UNQ2 ermF GO:0031167 rRNA methylation biological_process ACCEPT genes/BACFG/ermF/ermF-ai-review.yaml PTHR11727 PTN000919750 AN585 ok True PTN000197843 AN0 1 SPECIATION LUCA LUCA True True False 341 4 UniProtKB:Q8WVM0|MGI:MGI:2146851|UniProtKB:P06992|UniProtKB:Q9UNQ2 CDK16 GO:0005634 nucleus cellular_component KEEP_AS_NON_CORE genes/BALMU/A0A8B8WEG2/A0A8B8WEG2-ai-review.yaml PTHR24056 PTN000623744 AN1875 ok True PTN000623091 AN0 16 DUPLICATION True True 2533 80 SGD:S000002266|UniProtKB:P06493|MGI:MGI:1196224|UniProtKB:Q9BWU1|UniProtKB:Q96VK3|RGD:621111|UniProtKB:Q9NYV4|UniProtKB:Q9UQ88|AGI_LocusCode:AT1G66750|UniProtKB:Q384V5|RGD:2319|dictyBase:DDB_G0267442|MGI:MGI:88353|PomBase:SPBC18H10.15|MGI:MGI:894318|UniProtKB:Q586Q3|UniProtKB:Q00535|UniProtKB:P21127|AGI_LocusCode:AT3G48750|PomBase:SPCC16C4.11|WB:WBGene00000405|UniProtKB:Q14004|UniProtKB:P50613|PomBase:SPBC11B10.09|UniProtKB:P24941|dictyBase:DDB_G0272813|AGI_LocusCode:AT5G63610|UniProtKB:Q13523|UniProtKB:Q8IDW1|RGD:70514|WB:WBGene00015203|UniProtKB:P49336|AGI_LocusCode:AT1G67580|MGI:MGI:88357|PomBase:SPBC32H8.10|RGD:70486|PomBase:SPBC19F8.07|ZFIN:ZDB-GENE-081022-110|MGI:MGI:104772|FB:FBgn0037093|FB:FBgn0019949|RGD:619874|FB:FBgn0015618|UniProtKB:Q382V0|UniProtKB:P79432|SGD:S000005952|UniProtKB:Q00532|MGI:MGI:1916812|MGI:MGI:109584|PomBase:SPAC23H4.17c|SGD:S000000364|AGI_LocusCode:AT5G63370|dictyBase:DDB_G0288677|SGD:S000001622|AGI_LocusCode:AT3G54180|UniProtKB:Q00646|UniProtKB:Q92772|UniProtKB:Q583M3|WB:WBGene00013917|RGD:621120|MGI:MGI:88351|MGI:MGI:102956|UniProtKB:P11802|UniProtKB:O76039|SGD:S000006365|UniProtKB:Q8IJQ1|UniProtKB:Q15131|MGI:MGI:101765|UniProtKB:Q00534|CGD:CAL0000191207|FB:FBgn0263237|UniProtKB:P61075|PomBase:SPAC2F3.15|SGD:S000005963|UniProtKB:P50750|AGI_LocusCode:AT5G64960|UniProtKB:O94921|RGD:621124|MGI:MGI:1328368|UniProtKB:Q8IZL9 CDK16 GO:0005737 cytoplasm cellular_component ACCEPT genes/BALMU/A0A8B8WEG2/A0A8B8WEG2-ai-review.yaml PTHR24056 PTN000623744 AN1875 ok True PTN002373304 AN1727 15 SPECIATION Eukaryota Eukaryota True False True 204 12 SGD:S000005952|RGD:70514|WB:WBGene00000407|UniProtKB:Q00536|MGI:MGI:894318|MGI:MGI:101765|UniProtKB:Q00535|dictyBase:DDB_G0288677|WB:WBGene00003961|RGD:620584|MGI:MGI:97516|UniProtKB:O94921 CDK16 GO:0006887 exocytosis biological_process KEEP_AS_NON_CORE genes/BALMU/A0A8B8WEG2/A0A8B8WEG2-ai-review.yaml PTHR24056 PTN000623744 AN1875 ok True PTN004656776 AN1870 5 SPECIATION Euteleostomi Euteleostomi True False False 17 1 MGI:MGI:97516 CDK16 GO:0008021 synaptic vesicle cellular_component UNDECIDED genes/BALMU/A0A8B8WEG2/A0A8B8WEG2-ai-review.yaml PTHR24056 PTN000623744 AN1875 ok True PTN004656776 AN1870 5 SPECIATION Euteleostomi Euteleostomi True False False 17 1 MGI:MGI:97516 CDK16 GO:0031175 neuron projection development biological_process KEEP_AS_NON_CORE genes/BALMU/A0A8B8WEG2/A0A8B8WEG2-ai-review.yaml PTHR24056 PTN000623744 AN1875 ok True PTN004656776 AN1870 5 SPECIATION Euteleostomi Euteleostomi True False False 17 1 MGI:MGI:97516 Betv1 GO:0005634 nucleus cellular_component MARK_AS_OVER_ANNOTATED genes/BETPN/Betv1/Betv1-ai-review.yaml PTHR31213 PTN007850272 AN894 ok True PTN001581255 AN0 19 DUPLICATION True True 1221 11 UniProtKB:Q5Z8S0|UniProtKB:Q6I5C3|AGI_LocusCode:AT4G01026|UniProtKB:Q7XBY6|AGI_LocusCode:AT4G17870|AGI_LocusCode:AT5G05440|AGI_LocusCode:AT5G46790|UniProtKB:Q6EN42|AGI_LocusCode:AT5G53160|AGI_LocusCode:AT2G38310|AGI_LocusCode:AT2G40330 Betv2 GO:0003785 actin monomer binding molecular_function ACCEPT genes/BETPN/Betv2/Betv2-ai-review.yaml PTHR11604 PTN007517786 AN344 ok True PTN000176159 AN0 18 SPECIATION Eukaryota Eukaryota True True True 362 9 dictyBase:DDB_G0287125|UniProtKB:Q9FR39|UniProtKB:P35083|PomBase:SPAC4A8.15c|UniProtKB:P35081|SGD:S000005648|dictyBase:DDB_G0286187|UniProtKB:O22655|UniProtKB:P35082 Betv2 GO:0005938 cell cortex cellular_component KEEP_AS_NON_CORE genes/BETPN/Betv2/Betv2-ai-review.yaml PTHR11604 PTN007517786 AN344 ok True PTN000176159 AN0 18 SPECIATION Eukaryota Eukaryota True True True 362 2 dictyBase:DDB_G0271142|PomBase:SPAC4A8.15c cpi-2 GO:0005737 cytoplasm cellular_component REMOVE genes/BRUMA/cpi-2/cpi-2-ai-review.yaml PTHR46186 PTN008193545 AN132 ok True PTN005285938 AN0 4 SPECIATION Eumetazoa Eumetazoa True True False 103 5 RGD:2432|UniProtKB:P01034|WB:WBGene00000534|RGD:735160|MGI:MGI:1930004 cpi-2 GO:0031982 vesicle cellular_component KEEP_AS_NON_CORE genes/BRUMA/cpi-2/cpi-2-ai-review.yaml PTHR46186 PTN008193545 AN132 ok True PTN005285938 AN0 4 SPECIATION Eumetazoa Eumetazoa True True False 103 2 RGD:735160|RGD:2432 CNNM4 GO:0015693 magnesium ion transport biological_process ACCEPT genes/CANLF/A0A8I3PI07/A0A8I3PI07-ai-review.yaml PTHR12064 PTN000248941 AN660 ok True PTN002635769 AN635 8 SPECIATION Euteleostomi Euteleostomi True False False 24 1 MGI:MGI:2151060 ALB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/CANLF/ALB/ALB-ai-review.yaml PTHR11385 PTN000147397 AN147 no_same_term_ibd_on_path False ALB GO:0036094 small molecule binding molecular_function KEEP_AS_NON_CORE genes/CANLF/ALB/ALB-ai-review.yaml PTHR11385 PTN000147397 AN147 ok True PTN000147344 AN0 11 DUPLICATION True True 91 8 UniProtKB:P02769|UniProtKB:P43652|RGD:2667|UniProtKB:P02768|RGD:2085|UniProtKB:P19121|UniProtKB:P08835|UniProtKB:P02774 ALB GO:0072562 blood microparticle cellular_component KEEP_AS_NON_CORE genes/CANLF/ALB/ALB-ai-review.yaml PTHR11385 PTN000147397 AN147 no_same_term_ibd_on_path False ALB GO:1903981 enterobactin binding molecular_function ACCEPT genes/CANLF/ALB/ALB-ai-review.yaml PTHR11385 PTN000147397 AN147 ok True PTN008319942 AN113 6 SPECIATION Mammalia Mammalia True False True 19 2 UniProtKB:P02769|UniProtKB:P02768 Canf2 GO:0005549 odorant binding molecular_function ACCEPT genes/CANLF/Canf2/Canf2-ai-review.yaml PTHR11430 PTN000152996 AN464 ok True PTN000152998 AN409 4 SPECIATION Eutheria Eutheria True False True 42 5 MGI:MGI:3709619|RGD:708508|MGI:MGI:3709617|MGI:MGI:97233|MGI:MGI:3651981 Canf6 GO:0005549 odorant binding molecular_function ACCEPT genes/CANLF/Canf6/Canf6-ai-review.yaml PTHR11430 PTN001350133 AN465 ok True PTN000152998 AN409 4 SPECIATION Eutheria Eutheria True False True 42 5 MGI:MGI:3709619|RGD:708508|MGI:MGI:3709617|MGI:MGI:97233|MGI:MGI:3651981 CoBra GO:0000785 chromatin cellular_component ACCEPT genes/CAPO3/CoBra/CoBra-ai-review.yaml PTHR11267 PTN000137774 AN1 ok True PTN004251338 AN0 1 SPECIATION Opisthokonts Opisthokonts True True False 543 7 ZFIN:ZDB-GENE-990615-5|UniProtKB:O15178|MGI:MGI:1201683|MGI:MGI:102539|MGI:MGI:98472|ZFIN:ZDB-GENE-020416-5|ZFIN:ZDB-GENE-980526-437 CoBra GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific molecular_function ACCEPT genes/CAPO3/CoBra/CoBra-ai-review.yaml PTHR11267 PTN000137774 AN1 ok True PTN004251338 AN0 1 SPECIATION Opisthokonts Opisthokonts True True False 543 20 FB:FBgn0261963|FB:FBgn0035956|MGI:MGI:98493|MGI:MGI:102541|FB:FBgn0011723|MGI:MGI:1277234|MGI:MGI:1891158|UniProtKB:O15178|MGI:MGI:1888496|MGI:MGI:1352483|MGI:MGI:1923615|UniProtKB:O15119|MGI:MGI:1888984|UniProtKB:Q99593|UniProtKB:Q9UMR3|ZFIN:ZDB-GENE-001228-1|UniProtKB:Q13207|MGI:MGI:98472|UniProtKB:Q9UL17|FB:FBgn0028789 CoBra GO:0001708 cell fate specification biological_process REMOVE genes/CAPO3/CoBra/CoBra-ai-review.yaml PTHR11267 PTN000137774 AN1 ok True PTN000137774 AN1 0 DUPLICATION Opisthokonts True False False 542 10 WB:WBGene00006554|WB:WBGene00003376|ZFIN:ZDB-GENE-001228-1|ZFIN:ZDB-GENE-990726-27|MGI:MGI:98493|WB:WBGene00006543|MGI:MGI:102539|FB:FBgn0261963|WB:WBGene00003106|MGI:MGI:1201683 CoBra GO:0006357 regulation of transcription by RNA polymerase II biological_process ACCEPT genes/CAPO3/CoBra/CoBra-ai-review.yaml PTHR11267 PTN000137774 AN1 ok True PTN004251338 AN0 1 SPECIATION Opisthokonts Opisthokonts True True False 543 38 FB:FBgn0011723|MGI:MGI:107404|FB:FBgn0035956|MGI:MGI:98493|UniProtKB:O15178|MGI:MGI:1891158|MGI:MGI:1888984|UniProtKB:O15119|UniProtKB:O95936|UniProtKB:P87377|MGI:MGI:1277234|WB:WBGene00006554|UniProtKB:Q8AV66|UniProtKB:Q8AX98|UniProtKB:Q13207|MGI:MGI:98495|MGI:MGI:102539|UniProtKB:Q99593|RGD:735203|FB:FBgn0000179|FB:FBgn0028789|FB:FBgn0021767|ZFIN:ZDB-GENE-991124-7|FB:FBgn0016660|MGI:MGI:1201683|MGI:MGI:102541|WB:WBGene00004750|WB:WBGene00003106|FB:FBgn0261963|UniProtKB:P24781|MGI:MGI:1888496|UniProtKB:Q9Y458|MGI:MGI:1923615|MGI:MGI:1352483|FB:FBgn0035954|UniProtKB:Q9UL17|MGI:MGI:98472|MGI:MGI:98494 coHpo GO:0005737 cytoplasm cellular_component ACCEPT genes/CAPO3/coHpo/coHpo-ai-review.yaml PTHR48012 PTN008481874 AN51 ok True PTN004698611 AN0 3 DUPLICATION True True 435 23 RGD:621643|UniProtKB:O00506|UniProtKB:Q388G0|WB:WBGene00013355|UniProtKB:Q4GZ66|UniProtKB:Q9Y4K4|PomBase:SPBC17F3.02|RGD:1561742|UniProtKB:Q9H2G2|UniProtKB:Q57ZC6|RGD:727809|FB:FBgn0023083|MGI:MGI:1346883|UniProtKB:Q9UEW8|FB:FBgn0263395|FB:FBgn0035001|UniProtKB:Q9P289|UniProtKB:Q9Y6E0|dictyBase:DDB_G0286359|dictyBase:DDB_G0283265|UniProtKB:O95747|WB:WBGene00001526|AGI_LocusCode:AT1G53165 coITGB2 GO:0005178 integrin binding molecular_function KEEP_AS_NON_CORE genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 6 UniProtKB:P05106|RGD:2927|MGI:MGI:96610|MGI:MGI:96615|MGI:MGI:96614|MGI:MGI:96612 coITGB2 GO:0005925 focal adhesion cellular_component MARK_AS_OVER_ANNOTATED genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 9 WB:WBGene00003930|UniProtKB:P07228|MGI:MGI:96614|MGI:MGI:96612|FB:FBgn0004657|RGD:628868|UniProtKB:P18564|UniProtKB:P05106|RGD:2927 coITGB2 GO:0007160 cell-matrix adhesion biological_process MODIFY genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 10 UniProtKB:P05107|UniProtKB:P05556|UniProtKB:P18084|MGI:MGI:96612|UniProtKB:P26010|MGI:MGI:96615|UniProtKB:P16144|ZFIN:ZDB-GENE-030909-10|MGI:MGI:96610|UniProtKB:P05106 coITGB2 GO:0007229 integrin-mediated signaling pathway biological_process UNDECIDED genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 11 UniProtKB:P05107|UniProtKB:P26012|UniProtKB:P05556|UniProtKB:P53714|FB:FBgn0004657|MGI:MGI:96614|UniProtKB:P18084|MGI:MGI:96612|UniProtKB:P26010|MGI:MGI:96611|UniProtKB:P05106 coITGB2 GO:0008305 integrin complex cellular_component ACCEPT genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 19 UniProtKB:P05106|MGI:MGI:96610|UniProtKB:P18564|MGI:MGI:96613|UniProtKB:P26010|FB:FBgn0004657|WB:WBGene00003930|UniProtKB:P05556|UniProtKB:P26012|MGI:MGI:1338035|ZFIN:ZDB-GENE-071207-2|RGD:2927|FB:FBgn0010395|MGI:MGI:96611|MGI:MGI:96615|RGD:628868|UniProtKB:P18084|MGI:MGI:96614|UniProtKB:P05107 coITGB2 GO:0009986 cell surface cellular_component KEEP_AS_NON_CORE genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 16 MGI:MGI:96615|MGI:MGI:96611|UniProtKB:P16144|RGD:2927|UniProtKB:P05107|UniProtKB:P18084|RGD:628868|UniProtKB:P26010|RGD:1305581|MGI:MGI:96613|UniProtKB:P05106|MGI:MGI:96610|UniProtKB:P26012|WB:WBGene00003930|UniProtKB:P05556|MGI:MGI:96612 coITGB2 GO:0016477 cell migration biological_process UNDECIDED genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 13 MGI:MGI:96611|ZFIN:ZDB-GENE-030909-10|ZFIN:ZDB-GENE-110411-4|UniProtKB:P05107|UniProtKB:P18084|MGI:MGI:96616|RGD:1305581|UniProtKB:P26010|MGI:MGI:96613|UniProtKB:P05106|MGI:MGI:96610|UniProtKB:P05556|FB:FBgn0004657 coITGB2 GO:0033627 cell adhesion mediated by integrin biological_process ACCEPT genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 8 MGI:MGI:96615|UniProtKB:P18564|UniProtKB:P05106|ZFIN:ZDB-GENE-030909-10|RGD:2927|UniProtKB:P05107|UniProtKB:P05556|FB:FBgn0004657 coITGB2 GO:0098609 cell-cell adhesion biological_process MARK_AS_OVER_ANNOTATED genes/CAPO3/coITGB2/coITGB2-ai-review.yaml PTHR10082 PTN002560695 AN134 ok True PTN000801545 AN0 7 SPECIATION Eumetazoa Eumetazoa False True True 239 8 UniProtKB:P26010|RGD:1305581|MGI:MGI:96611|UniProtKB:P05106|UniProtKB:P05107|UniProtKB:P05556|MGI:MGI:96612|UniProtKB:P18084 coWts GO:0005856 cytoskeleton cellular_component MARK_AS_OVER_ANNOTATED genes/CAPO3/coWts/coWts-ai-review.yaml PTHR22988 PTN001122925 AN21 ok True PTN002743840 AN1 3 SPECIATION Eukaryota Eukaryota True False True 196 9 UniProtKB:Q9Y5S2|UniProtKB:O75116|UniProtKB:Q5VT25|MGI:MGI:107926|MGI:MGI:107927|FB:FBgn0002466|RGD:621406|RGD:621753|MGI:MGI:105313 coWts GO:0031032 actomyosin structure organization biological_process REMOVE genes/CAPO3/coWts/coWts-ai-review.yaml PTHR22988 PTN001122925 AN21 ok True PTN002743840 AN1 3 SPECIATION Eukaryota Eukaryota True False True 196 9 UniProtKB:Q5VT25|WB:WBGene00006437|FB:FBgn0003149|UniProtKB:Q9Y5S2|WB:WBGene00006754|RGD:621753|RGD:621406|FB:FBgn0026181|FB:FBgn0002466 coYki GO:0003713 transcription coactivator activity molecular_function ACCEPT genes/CAPO3/coYki/coYki-ai-review.yaml PTHR17616 PTN001446770 AN2 ok True PTN000427153 AN0 2 SPECIATION Eukaryota Eukaryota True True False 71 6 MGI:MGI:103262|FB:FBgn0034970|UniProtKB:Q9GZV5|UniProtKB:P46937|MGI:MGI:1917649|ZFIN:ZDB-GENE-030131-9710 coYki GO:0035329 hippo signaling biological_process ACCEPT genes/CAPO3/coYki/coYki-ai-review.yaml PTHR17616 PTN001446770 AN2 ok True PTN000427153 AN0 2 SPECIATION Eukaryota Eukaryota True True False 71 4 UniProtKB:P46937|FB:FBgn0034970|UniProtKB:Q9GZV5|MGI:MGI:103262 coYki GO:0045944 positive regulation of transcription by RNA polymerase II biological_process ACCEPT genes/CAPO3/coYki/coYki-ai-review.yaml PTHR17616 PTN001446770 AN2 ok True PTN000427153 AN0 2 SPECIATION Eukaryota Eukaryota True True False 71 5 UniProtKB:P46937|MGI:MGI:1917649|WB:WBGene00008748|MGI:MGI:103262|FB:FBgn0034970 fliI GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function REMOVE genes/CAUVC/fliI/fliI-ai-review.yaml PTHR15184 PTN000390110 AN30 ok True PTN008558586 AN4 5 DUPLICATION LUCA True False True 330 4 UniProtKB:P0ABB4|PomBase:SPAC222.12c|SGD:S000003882|UniProtKB:P06576 dorR GO:0000156 phosphorelay response regulator activity molecular_function ACCEPT genes/CERSP/dorR/dorR-ai-review.yaml PTHR48111 PTN001238482 AN253 ok True PTN000724188 AN0 6 SPECIATION LUCA LUCA True True True 475 10 UniProtKB:P0AE88|UniProtKB:P0AA16|UniProtKB:P30843|UniProtKB:Q9I2U3|UniProtKB:P0A9Q1|UniProtKB:Q8DPL7|UniProtKB:Q8DN02|UniProtKB:O07776|UniProtKB:P36556|UniProtKB:P38684 dorR GO:0000976 transcription cis-regulatory region binding molecular_function ACCEPT genes/CERSP/dorR/dorR-ai-review.yaml PTHR48111 PTN001238482 AN253 ok True PTN000724188 AN0 6 SPECIATION LUCA LUCA True True True 475 12 UniProtKB:P08368|UniProtKB:P0AA19|UniProtKB:P0AA16|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P26275|UniProtKB:Q8EE50|UniProtKB:Q8DN02|UniProtKB:P21866|UniProtKB:O24973|UniProtKB:Q8EHJ3|UniProtKB:P69228 dorR GO:0005829 cytosol cellular_component ACCEPT genes/CERSP/dorR/dorR-ai-review.yaml PTHR48111 PTN001238482 AN253 ok True PTN000724188 AN0 6 SPECIATION LUCA LUCA True True True 475 4 UniProtKB:P69228|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P0AE88 dorR GO:0032993 protein-DNA complex cellular_component ACCEPT genes/CERSP/dorR/dorR-ai-review.yaml PTHR48111 PTN001238482 AN253 ok True PTN000724188 AN0 6 SPECIATION LUCA LUCA True True True 475 6 UniProtKB:Q8EE50|UniProtKB:P26275|UniProtKB:P0A9Q1|UniProtKB:P23836|UniProtKB:Q8EHJ3|UniProtKB:O24973 Q7NUH2 GO:0006950 response to stress biological_process UNDECIDED genes/CHRVO/Q7NUH2/Q7NUH2-ai-review.yaml PTHR33164 PTN002109393 AN16 ok True PTN002109389 AN0 1 SPECIATION LUCA LUCA True True False 229 2 UniProtKB:O34777|UniProtKB:P27245 A0A8C2TBA7 GO:0005576 extracellular region cellular_component ACCEPT genes/COTJA/A0A8C2TBA7/A0A8C2TBA7-ai-review.yaml PTHR10680 PTN000840922 AN74 ok True PTN000840899 AN3 10 SPECIATION Eumetazoa Eumetazoa True False True 66 2 FB:FBgn0262728|RGD:3252 HSPH1 GO:0005634 nucleus cellular_component KEEP_AS_NON_CORE genes/CRIGR/HSPH1/HSPH1-ai-review.yaml PTHR45639 PTN000452919 AN27 ok True PTN000452854 AN1 18 SPECIATION Eukaryota Eukaryota True False True 288 4 MGI:MGI:105053|UniProtKB:F4HQD4|UniProtKB:Q92598|AGI_LocusCode:AT1G79930 HSPH1 GO:0005829 cytosol cellular_component ACCEPT genes/CRIGR/HSPH1/HSPH1-ai-review.yaml PTHR45639 PTN000452919 AN27 ok True PTN000452854 AN1 18 SPECIATION Eukaryota Eukaryota True False True 288 5 UniProtKB:F4HQD4|UniProtKB:P34932|UniProtKB:Q92598|AGI_LocusCode:AT1G79930|UniProtKB:O95757 HSPH1 GO:0006457 protein folding biological_process KEEP_AS_NON_CORE genes/CRIGR/HSPH1/HSPH1-ai-review.yaml PTHR45639 PTN000452919 AN27 ok True PTN000452854 AN1 18 SPECIATION Eukaryota Eukaryota True False True 288 5 WB:WBGene00016250|CGD:CAL0000182153|SGD:S000000373|MGI:MGI:105053|SGD:S000006027 AmiC2 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/CYLST/AmiC2/AmiC2-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 nrfA GO:0019645 anaerobic electron transport chain biological_process ACCEPT genes/DESPS/nrfA/nrfA-ai-review.yaml PTHR30633 PTN002024784 AN11 ok True PTN000771929 AN0 2 SPECIATION Eubacteria Eubacteria True True False 11 1 UniProtKB:P0ABK9 nrfA GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/DESPS/nrfA/nrfA-ai-review.yaml PTHR30633 PTN002024784 AN11 ok True PTN000771929 AN0 2 SPECIATION Eubacteria Eubacteria True True False 11 1 UniProtKB:P0ABK9 K9IFT7 GO:0002227 innate immune response in mucosa biological_process ACCEPT genes/DESRO/K9IFT7/K9IFT7-ai-review.yaml PTHR21388 PTN000483423 AN2 ok True PTN000483422 AN0 2 SPECIATION Amniota Amniota True True False 38 1 UniProtKB:P60022 K9IFT7 GO:0005615 extracellular space cellular_component ACCEPT genes/DESRO/K9IFT7/K9IFT7-ai-review.yaml PTHR21388 PTN000483423 AN2 no_same_term_ibd_on_path False K9IFT7 GO:0031731 CCR6 chemokine receptor binding molecular_function KEEP_AS_NON_CORE genes/DESRO/K9IFT7/K9IFT7-ai-review.yaml PTHR21388 PTN000483423 AN2 ok True PTN000483422 AN0 2 SPECIATION Amniota Amniota True True False 38 1 UniProtKB:P60022 K9IFT7 GO:0050829 defense response to Gram-negative bacterium biological_process ACCEPT genes/DESRO/K9IFT7/K9IFT7-ai-review.yaml PTHR21388 PTN000483423 AN2 ok True PTN000483422 AN0 2 SPECIATION Amniota Amniota True True False 38 3 UniProtKB:Q6IV18|UniProtKB:Q6QLQ9|UniProtKB:P60022 K9IFT7 GO:0050830 defense response to Gram-positive bacterium biological_process ACCEPT genes/DESRO/K9IFT7/K9IFT7-ai-review.yaml PTHR21388 PTN000483423 AN2 ok True PTN000483422 AN0 2 SPECIATION Amniota Amniota True True False 38 3 UniProtKB:P60022|UniProtKB:Q6QLQ9|UniProtKB:Q6IV18 K9IIP0 GO:0005615 extracellular space cellular_component ACCEPT genes/DESRO/K9IIP0/K9IIP0-ai-review.yaml PTHR46908 PTN002930566 AN39 no_same_term_ibd_on_path False K9IIP0 GO:0050728 negative regulation of inflammatory response biological_process ACCEPT genes/DESRO/K9IIP0/K9IIP0-ai-review.yaml PTHR46908 PTN002930566 AN39 ok True PTN002930559 AN22 6 SPECIATION Euteleostomi Euteleostomi True False False 24 1 UniProtKB:P98066 K9IJK6 GO:0014909 smooth muscle cell migration biological_process MARK_AS_OVER_ANNOTATED genes/DESRO/K9IJK6/K9IJK6-ai-review.yaml PTHR24264 PTN000667065 AN13 ok True PTN002799995 AN8 5 SPECIATION Euteleostomi Euteleostomi True False False 23 1 MGI:MGI:97610 K9IJK6 GO:0031639 plasminogen activation biological_process ACCEPT genes/DESRO/K9IJK6/K9IJK6-ai-review.yaml PTHR24264 PTN000667065 AN13 ok True PTN002799995 AN8 5 SPECIATION Euteleostomi Euteleostomi True False False 23 3 RGD:3342|UniProtKB:P00750|UniProtKB:Q28198 K9IJK6 GO:0048008 platelet-derived growth factor receptor signaling pathway biological_process MARK_AS_OVER_ANNOTATED genes/DESRO/K9IJK6/K9IJK6-ai-review.yaml PTHR24264 PTN000667065 AN13 ok True PTN008611606 AN9 4 SPECIATION Tetrapoda Tetrapoda True False False 20 1 MGI:MGI:97610 K9IMD0 GO:0005769 early endosome cellular_component MARK_AS_OVER_ANNOTATED genes/DESRO/K9IMD0/K9IMD0-ai-review.yaml PTHR11485 PTN000159979 AN15 ok True PTN000449834 AN2 13 SPECIATION Eukaryota Eukaryota True False True 102 3 MGI:MGI:98821|FB:FBgn0036299|UniProtKB:P02787 K9IMD0 GO:0005886 plasma membrane cellular_component MARK_AS_OVER_ANNOTATED genes/DESRO/K9IMD0/K9IMD0-ai-review.yaml PTHR11485 PTN000159979 AN15 ok True PTN000449834 AN2 13 SPECIATION Eukaryota Eukaryota True False True 102 3 UniProtKB:P02787|UniProtKB:P08582|FB:FBgn0036299 K9IMD0 GO:0019731 antibacterial humoral response biological_process KEEP_AS_NON_CORE genes/DESRO/K9IMD0/K9IMD0-ai-review.yaml PTHR11485 PTN000159979 AN15 ok True PTN002608129 AN9 6 SPECIATION Euteleostomi Euteleostomi True False True 44 2 UniProtKB:P24627|UniProtKB:P02788 K9IMD0 GO:0055037 recycling endosome cellular_component MARK_AS_OVER_ANNOTATED genes/DESRO/K9IMD0/K9IMD0-ai-review.yaml PTHR11485 PTN000159979 AN15 ok True PTN000449834 AN2 13 SPECIATION Eukaryota Eukaryota True False True 102 3 UniProtKB:P02787|MGI:MGI:98821|FB:FBgn0036299 K9IWC0 GO:0006182 cGMP biosynthetic process biological_process ACCEPT genes/DESRO/K9IWC0/K9IWC0-ai-review.yaml PTHR12167 PTN000255689 AN17 ok True PTN002638244 AN0 6 SPECIATION Euteleostomi Euteleostomi True True False 32 3 MGI:MGI:97369|UniProtKB:P23582|RGD:620850 K9IWC0 GO:0007168 receptor guanylyl cyclase signaling pathway biological_process ACCEPT genes/DESRO/K9IWC0/K9IWC0-ai-review.yaml PTHR12167 PTN000255689 AN17 ok True PTN002638244 AN0 6 SPECIATION Euteleostomi Euteleostomi True True False 32 2 RGD:620850|UniProtKB:P23582 LYZ GO:0050829 defense response to Gram-negative bacterium biological_process ACCEPT genes/DESRO/K9IWH5/K9IWH5-ai-review.yaml PTHR11407 PTN000150737 AN229 ok True PTN000150627 AN180 6 SPECIATION Amniota Amniota True False True 60 3 MGI:MGI:96902|RGD:3026|MGI:MGI:96897 LYZ GO:0050830 defense response to Gram-positive bacterium biological_process ACCEPT genes/DESRO/K9IWH5/K9IWH5-ai-review.yaml PTHR11407 PTN000150737 AN229 ok True PTN000150627 AN180 6 SPECIATION Amniota Amniota True False True 60 4 RGD:3026|MGI:MGI:96897|MGI:MGI:96902|UniProtKB:P61626 K9IWR0 GO:0043123 positive regulation of canonical NF-kappaB signal transduction biological_process ACCEPT genes/DESRO/K9IWR0/K9IWR0-ai-review.yaml PTHR11471 PTN000158030 AN55 ok True PTN000895255 AN0 11 SPECIATION Eumetazoa Eumetazoa True True True 223 6 MGI:MGI:104798|UniProtKB:P50591|MGI:MGI:1100089|UniProtKB:P01375|UniProtKB:P48023|RGD:3876 K9IWR0 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway biological_process ACCEPT genes/DESRO/K9IWR0/K9IWR0-ai-review.yaml PTHR11471 PTN000158030 AN55 ok True PTN000895255 AN0 11 SPECIATION Eumetazoa Eumetazoa True True True 223 4 RGD:3876|UniProtKB:P50591|MGI:MGI:107414|ZFIN:ZDB-GENE-010801-1 K9J287 GO:0003677 DNA binding molecular_function KEEP_AS_NON_CORE genes/DESRO/K9J287/K9J287-ai-review.yaml PTHR11371 PTN001684743 AN81 ok True PTN000889801 AN11 13 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False True 116 1 RGD:620669 K9J287 GO:0004530 deoxyribonuclease I activity molecular_function ACCEPT genes/DESRO/K9J287/K9J287-ai-review.yaml PTHR11371 PTN001684743 AN81 ok True PTN000889801 AN11 13 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False True 116 6 MGI:MGI:103157|UniProtKB:Q9YGI5|RGD:2510|UniProtKB:P11936|UniProtKB:P00639|UniProtKB:P24855 K9J287 GO:0005634 nucleus cellular_component REMOVE genes/DESRO/K9J287/K9J287-ai-review.yaml PTHR11371 PTN001684743 AN81 ok True PTN000889801 AN11 13 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False True 116 3 UniProtKB:Q13609|MGI:MGI:1314633|RGD:620669 K9J2R0 GO:0005886 plasma membrane cellular_component ACCEPT genes/DESRO/K9J2R0/K9J2R0-ai-review.yaml PTHR11731 PTN000198465 AN59 ok True PTN000198381 AN15 11 SPECIATION Opisthokonts Opisthokonts True False True 159 9 RGD:68402|UniProtKB:Q12884|UniProtKB:P27487|MGI:MGI:94921|RGD:1306427|UniProtKB:Q8N608|UniProtKB:P42658|FB:FBgn0031835|MGI:MGI:2442409 kdpC GO:0071805 potassium ion transmembrane transport biological_process ACCEPT genes/DESVH/Q725T8/Q725T8-ai-review.yaml PTHR30042 PTN000769307 AN4 ok True PTN001247299 AN0 2 SPECIATION LUCA LUCA True True False 19 1 UniProtKB:P03961 DVU_3336 GO:0005886 plasma membrane cellular_component ACCEPT genes/DESVH/Q725T9/Q725T9-ai-review.yaml PTHR45569 PTN008137371 AN1 ok True PTN001976096 AN0 1 SPECIATION Eubacteria Eubacteria True True False 18 1 UniProtKB:P21865 qmoC GO:0005886 plasma membrane cellular_component ACCEPT genes/DESVH/Q72DS9/Q72DS9-ai-review.yaml PTHR43255 PTN000938349 AN49 no_same_term_ibd_on_path False aprA GO:0000104 succinate dehydrogenase activity molecular_function REMOVE genes/DESVH/Q72DT2/Q72DT2-ai-review.yaml PTHR11632 PTN000908678 AN53 no_same_term_ibd_on_path False aprA GO:0005886 plasma membrane cellular_component ACCEPT genes/DESVH/Q72DT2/Q72DT2-ai-review.yaml PTHR11632 PTN000908678 AN53 ok True PTN000180228 AN14 3 DUPLICATION LUCA True False True 194 2 UniProtKB:P08065|UniProtKB:P0AC41 aprA GO:0009055 electron transfer activity molecular_function ACCEPT genes/DESVH/Q72DT2/Q72DT2-ai-review.yaml PTHR11632 PTN000908678 AN53 no_same_term_ibd_on_path False aprA GO:0009061 anaerobic respiration biological_process MODIFY genes/DESVH/Q72DT2/Q72DT2-ai-review.yaml PTHR11632 PTN000908678 AN53 ok True PTN000180228 AN14 3 DUPLICATION LUCA True False True 194 1 UniProtKB:P00363 aprA GO:0050660 flavin adenine dinucleotide binding molecular_function ACCEPT genes/DESVH/Q72DT2/Q72DT2-ai-review.yaml PTHR11632 PTN000908678 AN53 no_same_term_ibd_on_path False ADAR2 GO:0003725 double-stranded RNA binding molecular_function ACCEPT genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 2 RGD:2033|UniProtKB:P78563 ADAR2 GO:0003726 double-stranded RNA adenosine deaminase activity molecular_function ACCEPT genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 7 MGI:MGI:891999|RGD:2033|MGI:MGI:1889575|UniProtKB:P78563|FB:FBgn0026086|UniProtKB:P55265|WB:WBGene00000080 ADAR2 GO:0005730 nucleolus cellular_component UNDECIDED genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 4 UniProtKB:P78563|MGI:MGI:1889575|FB:FBgn0026086|UniProtKB:P55265 ADAR2 GO:0005737 cytoplasm cellular_component ACCEPT genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 5 WB:WBGene00000080|MGI:MGI:1923023|UniProtKB:P55265|MGI:MGI:1889575|WB:WBGene00000079 ADAR2 GO:0006382 adenosine to inosine editing biological_process ACCEPT genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 8 WB:WBGene00000079|MGI:MGI:1889575|MGI:MGI:891999|RGD:2033|UniProtKB:P78563|UniProtKB:P55265|WB:WBGene00000080|FB:FBgn0026086 ADAR2 GO:0008251 tRNA-specific adenosine deaminase activity molecular_function REMOVE genes/DOROP/ADAR2/ADAR2-ai-review.yaml PTHR10910 PTN000098697 AN127 ok True PTN000098822 AN0 6 SPECIATION Eukaryota Eukaryota True True True 189 2 AGI_LocusCode:AT1G01760|FB:FBgn0028658 AP180 GO:0000149 SNARE binding molecular_function UNDECIDED genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN000536700 AN6 5 SPECIATION Eukaryota Eukaryota True False False 758 6 RGD:621054|dictyBase:DDB_G0278685|AGI_LocusCode:AT2G01600|AGI_LocusCode:AT1G14910|UniProtKB:Q13492|RGD:69276 AP180 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding molecular_function ACCEPT genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN000536700 AN6 5 SPECIATION Eukaryota Eukaryota True False False 758 1 RGD:621054 AP180 GO:0006900 vesicle budding from membrane biological_process KEEP_AS_NON_CORE genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN000536700 AN6 5 SPECIATION Eukaryota Eukaryota True False False 758 1 UniProtKB:Q13492 AP180 GO:0008021 synaptic vesicle cellular_component MODIFY genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN001119474 AN10 1 SPECIATION Eumetazoa Eumetazoa True False False 76 2 RGD:69276|RGD:621054 AP180 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane biological_process ACCEPT genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 no_same_term_ibd_on_path False AP180 GO:0032050 clathrin heavy chain binding molecular_function ACCEPT genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN000536700 AN6 5 SPECIATION Eukaryota Eukaryota True False False 758 3 MGI:MGI:109132|RGD:69276|UniProtKB:Q13492 AP180 GO:0098894 extrinsic component of presynaptic endocytic zone membrane cellular_component ACCEPT genes/DORPE/AP180/AP180-ai-review.yaml PTHR22951 PTN000536703 AN11 ok True PTN001119474 AN10 1 SPECIATION Eumetazoa Eumetazoa True False False 76 2 RGD:621054|RGD:69276 cpx GO:0000149 SNARE binding molecular_function ACCEPT genes/DORPE/cpx/cpx-ai-review.yaml PTHR16705 PTN002703616 AN176 ok True PTN001047612 AN0 2 SPECIATION Eumetazoa Eumetazoa True True False 105 4 MGI:MGI:2685803|RGD:70945|RGD:70944|MGI:MGI:2384571 cpx GO:0016079 synaptic vesicle exocytosis biological_process MODIFY genes/DORPE/cpx/cpx-ai-review.yaml PTHR16705 PTN002703616 AN176 ok True PTN000422952 AN1 1 SPECIATION Bilateria Bilateria True False False 103 5 MGI:MGI:2384571|FB:FBgn0041605|MGI:MGI:104727|RGD:70945|RGD:70944 cpx GO:0031201 SNARE complex cellular_component MARK_AS_OVER_ANNOTATED genes/DORPE/cpx/cpx-ai-review.yaml PTHR16705 PTN002703616 AN176 ok True PTN001047612 AN0 2 SPECIATION Eumetazoa Eumetazoa True True False 105 3 RGD:70945|MGI:MGI:104727|RGD:70944 cpx GO:0043195 terminal bouton cellular_component ACCEPT genes/DORPE/cpx/cpx-ai-review.yaml PTHR16705 PTN002703616 AN176 ok True PTN000422952 AN1 1 SPECIATION Bilateria Bilateria True False False 103 2 FB:FBgn0041605|ZFIN:ZDB-GENE-060526-116 cpx GO:0046928 regulation of neurotransmitter secretion biological_process ACCEPT genes/DORPE/cpx/cpx-ai-review.yaml PTHR16705 PTN002703616 AN176 no_same_term_ibd_on_path False B4MAQ2 GO:0003723 RNA binding molecular_function ACCEPT genes/DROVI/B4MAQ2/B4MAQ2-ai-review.yaml PTHR11223 PTN000131780 AN368 ok True PTN000131750 AN304 11 SPECIATION Eukaryota Eukaryota True False False 107 2 MGI:MGI:1913789|UniProtKB:Q9HAV4 B4MAQ2 GO:0005634 nucleus cellular_component ACCEPT genes/DROVI/B4MAQ2/B4MAQ2-ai-review.yaml PTHR11223 PTN000131780 AN368 ok True PTN000131749 AN0 12 DUPLICATION True True 274 11 PomBase:SPAC1805.17|FB:FBgn0020497|UniProtKB:C8VRM0|UniProtKB:Q382A3|SGD:S000002743|AGI_LocusCode:AT3G05040|MGI:MGI:2144013|UniProtKB:Q9HAV4|UniProtKB:Q38AK6|UniProtKB:O14980|SGD:S000003450 B4MAQ2 GO:0005737 cytoplasm cellular_component ACCEPT genes/DROVI/B4MAQ2/B4MAQ2-ai-review.yaml PTHR11223 PTN000131780 AN368 ok True PTN000131749 AN0 12 DUPLICATION True True 274 4 SGD:S000002743|UniProtKB:Q382A3|UniProtKB:O14980|UniProtKB:Q9HAV4 B4MAQ2 GO:0006405 RNA export from nucleus biological_process ACCEPT genes/DROVI/B4MAQ2/B4MAQ2-ai-review.yaml PTHR11223 PTN000131780 AN368 ok True PTN000131750 AN304 11 SPECIATION Eukaryota Eukaryota True False False 107 3 SGD:S000002743|AGI_LocusCode:AT3G05040|UniProtKB:Q9HAV4 B4MAQ2 GO:0042565 RNA nuclear export complex cellular_component ACCEPT genes/DROVI/B4MAQ2/B4MAQ2-ai-review.yaml PTHR11223 PTN000131780 AN368 no_same_term_ibd_on_path False mcr-1 GO:0009244 lipopolysaccharide core region biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/ECOLX/mcr-1/mcr-1-ai-review.yaml PTHR30443 PTN002019544 AN25 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 mcr-1 GO:0016776 phosphotransferase activity, phosphate group as acceptor molecular_function MODIFY genes/ECOLX/mcr-1/mcr-1-ai-review.yaml PTHR30443 PTN002019544 AN25 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 mcr2 GO:0009244 lipopolysaccharide core region biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/ECOLX/mcr2/mcr2-ai-review.yaml PTHR30443 PTN002019544 AN25 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 mcr2 GO:0016776 phosphotransferase activity, phosphate group as acceptor molecular_function MODIFY genes/ECOLX/mcr2/mcr2-ai-review.yaml PTHR30443 PTN002019544 AN25 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 sfgA GO:0000976 transcription cis-regulatory region binding molecular_function ACCEPT genes/EMENI/sfgA/sfgA-ai-review.yaml PTHR37534 PTN002288087 AN228 ok True PTN005114750 AN3 6 SPECIATION Dikarya Dikarya True False True 137 4 SGD:S000002441|CGD:CAL0000176046|SGD:S000002329|CGD:CAL0000201205 sfgA GO:0003700 DNA-binding transcription factor activity molecular_function ACCEPT genes/EMENI/sfgA/sfgA-ai-review.yaml PTHR37534 PTN002288087 AN228 ok True PTN005114750 AN3 6 SPECIATION Dikarya Dikarya True False True 137 4 CGD:CAL0000197462|SGD:S000002329|CGD:CAL0000199898|UniProtKB:G5EAX1 sfgA GO:0045944 positive regulation of transcription by RNA polymerase II biological_process MARK_AS_OVER_ANNOTATED genes/EMENI/sfgA/sfgA-ai-review.yaml PTHR37534 PTN002288087 AN228 ok True PTN005114750 AN3 6 SPECIATION Dikarya Dikarya True False True 137 6 SGD:S000002329|CGD:CAL0000197462|UniProtKB:G5EAX1|CGD:CAL0000201205|SGD:S000002441|CGD:CAL0000176046 ALB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/FELCA/ALB/ALB-ai-review.yaml PTHR11385 PTN002604567 AN144 no_same_term_ibd_on_path False ALB GO:0036094 small molecule binding molecular_function KEEP_AS_NON_CORE genes/FELCA/ALB/ALB-ai-review.yaml PTHR11385 PTN002604567 AN144 ok True PTN000147344 AN0 11 DUPLICATION True True 91 8 UniProtKB:P02769|UniProtKB:P43652|RGD:2667|UniProtKB:P02768|RGD:2085|UniProtKB:P19121|UniProtKB:P08835|UniProtKB:P02774 ALB GO:0072562 blood microparticle cellular_component KEEP_AS_NON_CORE genes/FELCA/ALB/ALB-ai-review.yaml PTHR11385 PTN002604567 AN144 no_same_term_ibd_on_path False ALB GO:1903981 enterobactin binding molecular_function ACCEPT genes/FELCA/ALB/ALB-ai-review.yaml PTHR11385 PTN002604567 AN144 ok True PTN008319942 AN113 6 SPECIATION Mammalia Mammalia True False True 19 2 UniProtKB:P02769|UniProtKB:P02768 CH1 GO:0005496 steroid binding molecular_function KEEP_AS_NON_CORE genes/FELCA/CH1/CH1-ai-review.yaml PTHR21226 PTN001845951 AN32 ok True PTN000477008 AN0 3 SPECIATION Eutheria Eutheria True True False 25 1 MGI:MGI:87862 CSTA GO:0005829 cytosol cellular_component ACCEPT genes/FELCA/CSTA/CSTA-ai-review.yaml PTHR11414 PTN002605480 AN67 ok True PTN000151700 AN1 16 SPECIATION Unikonts Unikonts True False True 95 3 UniProtKB:P04080|dictyBase:DDB_G0291834|dictyBase:DDB_G0280439 Feld4 GO:0005549 odorant binding molecular_function ACCEPT genes/FELCA/Feld4/Feld4-ai-review.yaml PTHR11430 PTN002261935 AN460 ok True PTN000152998 AN409 3 SPECIATION Eutheria Eutheria True False False 42 5 MGI:MGI:3709619|RGD:708508|MGI:MGI:3709617|MGI:MGI:97233|MGI:MGI:3651981 Feld8 GO:0043129 surfactant homeostasis biological_process ACCEPT genes/FELCA/Feld8/Feld8-ai-review.yaml PTHR47015 PTN001629847 AN17 ok True PTN000053095 AN0 5 SPECIATION Theria Theria True True True 28 2 UniProtKB:Q9NP55|UniProtKB:P82615 AmiC1 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/FISTH/AmiC1/AmiC1-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 AmiC2 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/FISTH/AmiC2/AmiC2-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 pepV GO:0006526 L-arginine biosynthetic process biological_process REMOVE genes/FUSNU/pepV/pepV-ai-review.yaml PTHR43808 PTN000865753 AN247 ok True PTN000865743 AN227 1 SPECIATION Eubacteria Eubacteria True False False 29 1 UniProtKB:P23908 pepV GO:0008777 acetylornithine deacetylase activity molecular_function REMOVE genes/FUSNU/pepV/pepV-ai-review.yaml PTHR43808 PTN000865753 AN247 ok True PTN000865743 AN227 1 SPECIATION Eubacteria Eubacteria True False False 29 2 UniProtKB:Q8P8J5|UniProtKB:P23908 tbc1d14 GO:0005096 GTPase activator activity molecular_function UNDECIDED genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-ai-review.yaml PTHR47219 PTN009208344 AN123 ok True PTN002343965 AN24 9 SPECIATION Eukaryota Eukaryota True False True 133 2 UniProtKB:Q9Y3P9|UniProtKB:Q5R372 tbc1d14 GO:0031267 small GTPase binding molecular_function ACCEPT genes/GADMO/A0A8C5FPT8/A0A8C5FPT8-ai-review.yaml PTHR47219 PTN009208344 AN123 ok True PTN002343965 AN24 9 SPECIATION Eukaryota Eukaryota True False True 133 2 UniProtKB:Q9Y3P9|UniProtKB:Q5R372 fliI GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function REMOVE genes/HELPJ/fliI/fliI-ai-review.yaml PTHR15184 PTN002689426 AN25 ok True PTN008558586 AN4 3 DUPLICATION LUCA True False True 330 4 UniProtKB:P0ABB4|PomBase:SPAC222.12c|SGD:S000003882|UniProtKB:P06576 Cd44 GO:0004888 transmembrane signaling receptor activity molecular_function ACCEPT genes/HETGA/Cd44/Cd44-ai-review.yaml PTHR10225 PTN000027508 AN16 ok True PTN000812484 AN0 9 SPECIATION Eumetazoa Eumetazoa True True True 49 3 MGI:MGI:2136348|UniProtKB:P16070|MGI:MGI:88338 Cd44 GO:0006954 inflammatory response biological_process KEEP_AS_NON_CORE genes/HETGA/Cd44/Cd44-ai-review.yaml PTHR10225 PTN000027508 AN16 ok True PTN002566805 AN2 7 SPECIATION Euteleostomi Euteleostomi True False False 25 1 MGI:MGI:88338 Cd44 GO:0016323 basolateral plasma membrane cellular_component KEEP_AS_NON_CORE genes/HETGA/Cd44/Cd44-ai-review.yaml PTHR10225 PTN000027508 AN16 ok True PTN002566805 AN2 7 SPECIATION Euteleostomi Euteleostomi True False False 25 3 RGD:2307|UniProtKB:F1SGT4|MGI:MGI:88338 Cgas GO:0002218 activation of innate immune response biological_process ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 MGI:MGI:2442261|UniProtKB:Q8N884 Cgas GO:0002230 positive regulation of defense response to virus by host biological_process ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 MGI:MGI:2442261|UniProtKB:Q8N884 Cgas GO:0003682 chromatin binding molecular_function ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 UniProtKB:Q8N884|MGI:MGI:2442261 Cgas GO:0003690 double-stranded DNA binding molecular_function ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 UniProtKB:Q8N884|MGI:MGI:2442261 Cgas GO:0005634 nucleus cellular_component ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 MGI:MGI:2442261|UniProtKB:Q8N884 Cgas GO:0005829 cytosol cellular_component ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 MGI:MGI:2442261|UniProtKB:Q8N884 Cgas GO:0006974 DNA damage response biological_process ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 1 UniProtKB:Q8N884 Cgas GO:0032481 positive regulation of type I interferon production biological_process ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 MGI:MGI:2442261|UniProtKB:Q8N884 Cgas GO:0035861 site of double-strand break cellular_component ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 1 UniProtKB:Q8N884 Cgas GO:0038001 paracrine signaling biological_process ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 UniProtKB:Q8N884|MGI:MGI:2442261 Cgas GO:0061501 2',3'-cyclic GMP-AMP synthase activity molecular_function ACCEPT genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN000838114 AN296 12 SPECIATION Eumetazoa Eumetazoa True False True 134 8 UniProtKB:Q8N884|UniProtKB:I3LM39|MGI:MGI:2442261|FB:FBgn0034047|UniProtKB:D6WI29|UniProtKB:A7SFB5|FB:FBgn0050424|ZFIN:ZDB-GENE-090313-23 Cgas GO:0071360 cellular response to exogenous dsRNA biological_process MODIFY genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 1 MGI:MGI:2442261 Cgas GO:2000042 negative regulation of double-strand break repair via homologous recombination biological_process REMOVE genes/HETGA/Cgas/Cgas-ai-review.yaml PTHR10656 PTN000069395 AN437 ok True PTN002579681 AN431 6 SPECIATION Euteleostomi Euteleostomi True False False 23 2 UniProtKB:Q8N884|MGI:MGI:2442261 Has2 GO:0085029 extracellular matrix assembly biological_process ACCEPT genes/HETGA/Has2/Has2-ai-review.yaml PTHR22913 PTN000530842 AN63 ok True PTN000530809 AN0 12 SPECIATION LUCA LUCA True True True 86 3 MGI:MGI:107821|MGI:MGI:109599|MGI:MGI:106590 Ntrk1 GO:0010976 positive regulation of neuron projection development biological_process ACCEPT genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 no_same_term_ibd_on_path False Ntrk1 GO:0030424 axon cellular_component KEEP_AS_NON_CORE genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 ok True PTN001230900 AN2047 9 SPECIATION Bilateria Bilateria True False True 80 4 RGD:3213|RGD:620144|MGI:MGI:97383|MGI:MGI:97384 Ntrk1 GO:0043121 neurotrophin binding molecular_function ACCEPT genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 ok True PTN001230900 AN2047 9 SPECIATION Bilateria Bilateria True False True 80 4 RGD:3213|RGD:620144|MGI:MGI:97384|UniProtKB:Q16620 Ntrk1 GO:0043235 signaling receptor complex cellular_component ACCEPT genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 ok True PTN001230349 AN2 13 DUPLICATION False True 1548 23 FB:FBgn0015380|UniProtKB:P21860|UniProtKB:Q01973|UniProtKB:P07333|UniProtKB:P35916|MGI:MGI:95410|FB:FBgn0283499|UniProtKB:O15146|FB:FBgn0033791|UniProtKB:Q16620|UniProtKB:P08069|UniProtKB:P04626|UniProtKB:P11362|UniProtKB:P14616|UniProtKB:P06213|FB:FBgn0024245|UniProtKB:Q15303|UniProtKB:P17948|UniProtKB:P07949|UniProtKB:Q08345|UniProtKB:P04629|UniProtKB:Q16288|UniProtKB:P00533 Ntrk1 GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction biological_process KEEP_AS_NON_CORE genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 ok True PTN008618212 AN1833 12 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False True 194 3 UniProtKB:Q16288|RGD:3213|RGD:620144 Ntrk1 GO:1990090 cellular response to nerve growth factor stimulus biological_process ACCEPT genes/HETGA/Ntrk1/Ntrk1-ai-review.yaml PTHR24416 PTN000699860 AN2101 ok True PTN001230900 AN2047 9 SPECIATION Bilateria Bilateria True False True 80 4 UniProtKB:P04629|MGI:MGI:97383|RGD:3213|RGD:620144 Scn9a GO:0019228 neuronal action potential biological_process ACCEPT genes/HETGA/Scn9a/Scn9a-ai-review.yaml PTHR10037 PTN000004433 AN231 ok True PTN002559277 AN155 7 SPECIATION Euteleostomi Euteleostomi True False True 69 4 RGD:3632|MGI:MGI:98246|RGD:69364|ZFIN:ZDB-GENE-060906-1 Scn9a GO:0035725 sodium ion transmembrane transport biological_process ACCEPT genes/HETGA/Scn9a/Scn9a-ai-review.yaml PTHR10037 PTN000004433 AN231 ok True PTN000798901 AN3 13 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False True 169 8 RGD:3637|MGI:MGI:98251|MGI:MGI:98248|RGD:3636|FB:FBgn0285944|MGI:MGI:1345149|RGD:3632|ZFIN:ZDB-GENE-000828-1 Scn9a GO:0086010 membrane depolarization during action potential biological_process ACCEPT genes/HETGA/Scn9a/Scn9a-ai-review.yaml PTHR10037 PTN000004433 AN231 ok True PTN000004140 AN2 14 DUPLICATION Opisthokonts True False True 267 5 MGI:MGI:98246|MGI:MGI:98251|RGD:3637|RGD:3630|MGI:MGI:1345149 Tac1 GO:0006954 inflammatory response biological_process KEEP_AS_NON_CORE genes/HETGA/Tac1/Tac1-ai-review.yaml PTHR11250 PTN000134172 AN26 ok True PTN001679099 AN6 1 DUPLICATION Theria True False True 21 1 MGI:MGI:98474 Tac1 GO:0031835 substance P receptor binding molecular_function ACCEPT genes/HETGA/Tac1/Tac1-ai-review.yaml PTHR11250 PTN000134172 AN26 ok True PTN001679099 AN6 1 DUPLICATION Theria True False True 21 4 UniProtKB:P20366|RGD:3807|UniProtKB:Q86UU9|MGI:MGI:1931130 Trpv1 GO:0098703 calcium ion import across plasma membrane biological_process ACCEPT genes/HETGA/Trpv1/Trpv1-ai-review.yaml PTHR10582 PTN000061681 AN109 ok True PTN000061616 AN0 17 SPECIATION Eukaryota Eukaryota True True True 211 7 MGI:MGI:1927259|UniProtKB:Q8NER1|RGD:69335|UniProtKB:Q9H1D0|UniProtKB:Q9NQA5|UniProtKB:A0A480JHA1|RGD:628841 IRE1 GO:0051082 unfolded protein binding molecular_function MODIFY genes/HYPJE/IRE1/IRE1-ai-review.yaml PTHR13954 no_graft_node IRE1 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress biological_process MARK_AS_OVER_ANNOTATED genes/HYPJE/IRE1/IRE1-ai-review.yaml PTHR13954 PTN001017826 AN216 no_same_term_ibd_on_path False IRE1 GO:1990604 IRE1-TRAF2-ASK1 complex cellular_component REMOVE genes/HYPJE/IRE1/IRE1-ai-review.yaml PTHR13954 PTN001017826 AN216 no_same_term_ibd_on_path False A0A2K5UJ34 GO:0032474 otolith morphogenesis biological_process MARK_AS_OVER_ANNOTATED genes/MACFA/A0A2K5UJ34/A0A2K5UJ34-ai-review.yaml PTHR31859 PTN001275231 AN17 ok True PTN002840059 AN10 7 SPECIATION Euteleostomi Euteleostomi True False False 21 1 ZFIN:ZDB-GENE-050522-194 A0A2K5UJ34 GO:0060271 cilium assembly biological_process ACCEPT genes/MACFA/A0A2K5UJ34/A0A2K5UJ34-ai-review.yaml PTHR31859 PTN001275231 AN17 ok True PTN001275223 AN5 12 SPECIATION Eumetazoa Eumetazoa True False False 29 1 ZFIN:ZDB-GENE-050522-194 Pks1 GO:0004312 fatty acid synthase activity molecular_function REMOVE genes/METBS/Pks1/Pks1-ai-review.yaml PTHR43775 PTN008685048 AN261 ok True PTN000196555 AN0 6 SPECIATION LUCA LUCA True True True 200 6 RGD:620665|FB:FBgn0042627|UniProtKB:P49327|FB:FBgn0283427|dictyBase:DDB_G0275077|MGI:MGI:95485 ackA GO:0005829 cytosol cellular_component ACCEPT genes/METEA/ackA/ackA-ai-review.yaml PTHR21060 PTN002720962 AN47 ok True PTN001464611 AN41 2 SPECIATION Eubacteria Eubacteria True False False 14 1 UniProtKB:P0A6A3 ackA GO:0006083 acetate metabolic process biological_process ACCEPT genes/METEA/ackA/ackA-ai-review.yaml PTHR21060 PTN002720962 AN47 ok True PTN000471910 AN0 4 SPECIATION LUCA LUCA True True True 64 1 UniProtKB:P0A6A3 fumC GO:0006108 malate metabolic process biological_process ACCEPT genes/METEA/fumC/fumC-ai-review.yaml PTHR11444 PTN002262544 AN20 ok True PTN000154499 AN17 3 SPECIATION LUCA LUCA True False False 148 3 AGI_LocusCode:AT2G47510|UniProtKB:P07954|AGI_LocusCode:AT5G50950 gck GO:0005737 cytoplasm cellular_component ACCEPT genes/METEA/gck/gck-ai-review.yaml PTHR12227 PTN000260032 AN80 ok True PTN000259988 AN0 3 SPECIATION LUCA LUCA True True False 44 2 RGD:1591498|UniProtKB:Q8IVS8 gcvH GO:0005737 cytoplasm cellular_component ACCEPT genes/METEA/gcvH/gcvH-ai-review.yaml PTHR11715 PTN000196817 AN0 no_same_term_ibd_on_path False gcvH GO:0009249 protein lipoylation biological_process ACCEPT genes/METEA/gcvH/gcvH-ai-review.yaml PTHR11715 PTN000196817 AN0 no_same_term_ibd_on_path False gcvP GO:0005829 cytosol cellular_component ACCEPT genes/METEA/gcvP/gcvP-ai-review.yaml PTHR11773 PTN000206607 AN273 ok True PTN000206531 AN0 2 SPECIATION LUCA LUCA True True False 157 1 UniProtKB:P33195 gcvP GO:0005960 glycine cleavage complex cellular_component ACCEPT genes/METEA/gcvP/gcvP-ai-review.yaml PTHR11773 PTN000206607 AN273 no_same_term_ibd_on_path False gcvP GO:0016594 glycine binding molecular_function ACCEPT genes/METEA/gcvP/gcvP-ai-review.yaml PTHR11773 PTN000206607 AN273 no_same_term_ibd_on_path False gcvP GO:0030170 pyridoxal phosphate binding molecular_function ACCEPT genes/METEA/gcvP/gcvP-ai-review.yaml PTHR11773 PTN000206607 AN273 no_same_term_ibd_on_path False glyA GO:0005829 cytosol cellular_component ACCEPT genes/METEA/glyA/glyA-ai-review.yaml PTHR11680 PTN002269113 AN839 ok True PTN000188204 AN800 3 SPECIATION Eubacteria Eubacteria True False True 42 1 UniProtKB:P0A825 glyA GO:0046653 tetrahydrofolate metabolic process biological_process KEEP_AS_NON_CORE genes/METEA/glyA/glyA-ai-review.yaml PTHR11680 PTN002269113 AN839 ok True PTN000188065 AN0 4 SPECIATION LUCA LUCA True True True 460 6 MGI:MGI:1277989|UniProtKB:P34896|UniProtKB:P34897|UniProtKB:Q8I566|FB:FBgn0029823|MGI:MGI:98299 mdcD GO:0003989 acetyl-CoA carboxylase activity molecular_function REMOVE genes/METEA/mdcD/mdcD-ai-review.yaml PTHR42995 PTN002873918 AN104 no_same_term_ibd_on_path False mdcD GO:0006633 fatty acid biosynthetic process biological_process REMOVE genes/METEA/mdcD/mdcD-ai-review.yaml PTHR42995 PTN002873918 AN104 ok True PTN008677411 AN0 4 HORIZONTAL_TRANSFER True True 75 2 UniProtKB:P0A9Q5|UniProtKB:P9WQH9 mdcD GO:2001295 malonyl-CoA biosynthetic process biological_process REMOVE genes/METEA/mdcD/mdcD-ai-review.yaml PTHR42995 PTN002873918 AN104 no_same_term_ibd_on_path False mdh GO:0004459 L-lactate dehydrogenase (NAD+) activity molecular_function REMOVE genes/METEA/mdh/mdh-ai-review.yaml PTHR43128 PTN002875914 AN12 no_same_term_ibd_on_path False mdh GO:0006089 lactate metabolic process biological_process REMOVE genes/METEA/mdh/mdh-ai-review.yaml PTHR43128 PTN002875914 AN12 no_same_term_ibd_on_path False mluA GO:0015344 siderophore uptake transmembrane transporter activity molecular_function MODIFY genes/METEA/mluA/mluA-ai-review.yaml PTHR32552 PTN004950207 AN64 ok True PTN000793005 AN7 2 SPECIATION Eubacteria Eubacteria True False True 68 3 UniProtKB:Q9I116|UniProtKB:P75780|UniProtKB:P06971 mluR GO:0016989 sigma factor antagonist activity molecular_function ACCEPT genes/METEA/mluR/mluR-ai-review.yaml PTHR30273 PTN002410644 AN45 ok True PTN001250434 AN0 2 SPECIATION Eubacteria Eubacteria True True False 53 4 UniProtKB:Q9I192|UniProtKB:G3XCU5|UniProtKB:Q9I647|UniProtKB:Q9I115 mxbM GO:0000156 phosphorelay response regulator activity molecular_function ACCEPT genes/METEA/mxbM/mxbM-ai-review.yaml PTHR48111 PTN000724184 AN26 ok True PTN000724188 AN0 1 SPECIATION LUCA LUCA True True False 475 10 UniProtKB:P0AE88|UniProtKB:P0AA16|UniProtKB:P30843|UniProtKB:Q9I2U3|UniProtKB:P0A9Q1|UniProtKB:Q8DPL7|UniProtKB:Q8DN02|UniProtKB:O07776|UniProtKB:P36556|UniProtKB:P38684 mxbM GO:0000976 transcription cis-regulatory region binding molecular_function KEEP_AS_NON_CORE genes/METEA/mxbM/mxbM-ai-review.yaml PTHR48111 PTN000724184 AN26 ok True PTN000724188 AN0 1 SPECIATION LUCA LUCA True True False 475 12 UniProtKB:P08368|UniProtKB:P0AA19|UniProtKB:P0AA16|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P26275|UniProtKB:Q8EE50|UniProtKB:Q8DN02|UniProtKB:P21866|UniProtKB:O24973|UniProtKB:Q8EHJ3|UniProtKB:P69228 mxbM GO:0005829 cytosol cellular_component ACCEPT genes/METEA/mxbM/mxbM-ai-review.yaml PTHR48111 PTN000724184 AN26 ok True PTN000724188 AN0 1 SPECIATION LUCA LUCA True True False 475 4 UniProtKB:P69228|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P0AE88 mxbM GO:0032993 protein-DNA complex cellular_component KEEP_AS_NON_CORE genes/METEA/mxbM/mxbM-ai-review.yaml PTHR48111 PTN000724184 AN26 ok True PTN000724188 AN0 1 SPECIATION LUCA LUCA True True False 475 6 UniProtKB:Q8EE50|UniProtKB:P26275|UniProtKB:P0A9Q1|UniProtKB:P23836|UniProtKB:Q8EHJ3|UniProtKB:O24973 pckA GO:0005829 cytosol cellular_component ACCEPT genes/METEA/pckA/pckA-ai-review.yaml PTHR30031 PTN002408974 AN314 ok True PTN000768969 AN302 2 SPECIATION Eubacteria Eubacteria True False False 16 1 UniProtKB:P22259 sucB GO:0005829 cytosol cellular_component ACCEPT genes/METEA/sucB/sucB-ai-review.yaml PTHR43416 PTN000568037 AN551 ok True PTN002459361 AN510 3 DUPLICATION LUCA True False True 34 1 UniProtKB:P0AFG6 gatC GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation biological_process ACCEPT genes/METTP/gatC/gatC-ai-review.yaml PTHR15004 PTN000385051 AN1 ok True PTN000385050 AN0 1 SPECIATION LUCA LUCA True True False 117 1 UniProtKB:O43716 DHS GO:0005737 cytoplasm cellular_component ACCEPT genes/MISSI/DHS/DHS-ai-review.yaml PTHR11703 PTN004292120 AN164 ok True PTN000193988 AN0 15 SPECIATION LUCA LUCA True True False 157 3 UniProtKB:Q38BX0|UniProtKB:Q4GZD1|MGI:MGI:2683592 DHS GO:0034038 deoxyhypusine synthase activity molecular_function ACCEPT genes/MISSI/DHS/DHS-ai-review.yaml PTHR11703 PTN004292120 AN164 ok True PTN000193988 AN0 15 SPECIATION LUCA LUCA True True False 157 6 RGD:1303326|MGI:MGI:2683592|UniProtKB:Q38BX0|FB:FBgn0035854|SGD:S000001110|UniProtKB:P49366 MnSOD GO:0005739 mitochondrion cellular_component KEEP_AS_NON_CORE genes/MISSI/MnSOD/MnSOD-ai-review.yaml PTHR11404 PTN004256478 AN163 ok True PTN000150076 AN9 12 SPECIATION Eukaryota Eukaryota True False False 154 9 AGI_LocusCode:AT3G10920|SGD:S000001050|WB:WBGene00004932|CGD:CAL0000191321|MGI:MGI:98352|RGD:3732|UniProtKB:P09233|UniProtKB:P04179|PomBase:SPAC1486.01 MnSOD GO:0030145 manganese ion binding molecular_function ACCEPT genes/MISSI/MnSOD/MnSOD-ai-review.yaml PTHR11404 PTN004256478 AN163 ok True PTN004256454 AN7 13 HORIZONTAL_TRANSFER Archaea-Eukaryota True False False 155 4 PomBase:SPAC1486.01|UniProtKB:Q92450|UniProtKB:P04179|RGD:3732 A0A8B6GS20 GO:0005737 cytoplasm cellular_component ACCEPT genes/MYTGA/A0A8B6GS20/A0A8B6GS20-ai-review.yaml PTHR10807 PTN000086907 AN621 ok True PTN000743854 AN0 6 DUPLICATION True True 507 33 MGI:MGI:2443034|MGI:MGI:1858271|UniProtKB:Q96EF0|UniProtKB:Q9C0I1|WB:WBGene00003479|UniProtKB:Q13613|FB:FBgn0025802|UniProtKB:Q86WG5|UniProtKB:Q585F9|MGI:MGI:1099452|UniProtKB:Q9NYA4|UniProtKB:Q13614|RGD:1311865|MGI:MGI:2145637|UniProtKB:Q13496|UniProtKB:Q9Y217|UniProtKB:Q9Y216|UniProtKB:Q9NXD2|WB:WBGene00003476|RGD:1305378|UniProtKB:O95248|WB:WBGene00003478|AGI_LocusCode:AT5G04540|MGI:MGI:2442842|UniProtKB:Q96QG7|MGI:MGI:1891693|WB:WBGene00003475|MGI:MGI:1924366|UniProtKB:Q13615|AGI_LocusCode:AT3G10550|MGI:MGI:1921831|UniProtKB:A4FU01|FB:FBgn0025742 A0A8B6GS20 GO:0010507 negative regulation of autophagy biological_process MARK_AS_OVER_ANNOTATED genes/MYTGA/A0A8B6GS20/A0A8B6GS20-ai-review.yaml PTHR10807 PTN000086907 AN621 ok True PTN002246859 AN620 1 SPECIATION Eumetazoa Eumetazoa True False False 50 1 UniProtKB:Q96QG7 A0A8B6GS20 GO:0019903 protein phosphatase binding molecular_function ACCEPT genes/MYTGA/A0A8B6GS20/A0A8B6GS20-ai-review.yaml PTHR10807 PTN000086907 AN621 ok True PTN002246859 AN620 1 SPECIATION Eumetazoa Eumetazoa True False False 50 1 UniProtKB:Q96QG7 A0A8B6GS20 GO:0046856 phosphatidylinositol dephosphorylation biological_process MODIFY genes/MYTGA/A0A8B6GS20/A0A8B6GS20-ai-review.yaml PTHR10807 PTN000086907 AN621 ok True PTN008506586 AN616 5 SPECIATION Eukaryota Eukaryota True False True 183 3 UniProtKB:Q9Y217|UniProtKB:Q96EF0|MGI:MGI:1891693 NaBGL1_candidate_BGLU18_6 GO:0008422 beta-glucosidase activity molecular_function ACCEPT genes/NICAT/NaBGL1_candidate_BGLU18_6/NaBGL1_candidate_BGLU18_6-ai-review.yaml PTHR10353 PTN004151252 AN630 ok True PTN000039458 AN0 22 SPECIATION LUCA LUCA True True True 1567 30 AGI_LocusCode:AT1G52400|AGI_LocusCode:AT1G47600|UniProtKB:P49235|UniProtKB:Q75I94|AGI_LocusCode:AT5G26000|UniProtKB:A3BMZ5|UniProtKB:Q7XSK0|UniProtKB:Q1XH05|AGI_LocusCode:AT1G61810|AGI_LocusCode:AT1G66280|UniProtKB:Q75I93|UniProtKB:P09848|AGI_LocusCode:AT1G51470|AGI_LocusCode:AT2G44450|AGI_LocusCode:AT3G06510|RGD:620823|AGI_LocusCode:AT2G44490|UniProtKB:Q7XKV4|UniProtKB:Q1XH04|AGI_LocusCode:AT1G66270|AGI_LocusCode:AT5G36890|AGI_LocusCode:AT1G61820|UniProtKB:Q9H227|AGI_LocusCode:AT3G18080|UniProtKB:Q7XSK2|UniProtKB:Q41761|UniProtKB:Q1XIR9|AGI_LocusCode:AT3G09260|UniProtKB:D5MTF8|UniProtKB:Q8L7J2 NaBGL2_candidate_BGLU18_1 GO:0008422 beta-glucosidase activity molecular_function ACCEPT genes/NICAT/NaBGL2_candidate_BGLU18_1/NaBGL2_candidate_BGLU18_1-ai-review.yaml PTHR10353 PTN004151252 AN630 ok True PTN000039458 AN0 22 SPECIATION LUCA LUCA True True True 1567 30 AGI_LocusCode:AT1G52400|AGI_LocusCode:AT1G47600|UniProtKB:P49235|UniProtKB:Q75I94|AGI_LocusCode:AT5G26000|UniProtKB:A3BMZ5|UniProtKB:Q7XSK0|UniProtKB:Q1XH05|AGI_LocusCode:AT1G61810|AGI_LocusCode:AT1G66280|UniProtKB:Q75I93|UniProtKB:P09848|AGI_LocusCode:AT1G51470|AGI_LocusCode:AT2G44450|AGI_LocusCode:AT3G06510|RGD:620823|AGI_LocusCode:AT2G44490|UniProtKB:Q7XKV4|UniProtKB:Q1XH04|AGI_LocusCode:AT1G66270|AGI_LocusCode:AT5G36890|AGI_LocusCode:AT1G61820|UniProtKB:Q9H227|AGI_LocusCode:AT3G18080|UniProtKB:Q7XSK2|UniProtKB:Q41761|UniProtKB:Q1XIR9|AGI_LocusCode:AT3G09260|UniProtKB:D5MTF8|UniProtKB:Q8L7J2 NaODC_candidate_DCOR GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/NICAT/NaODC_candidate_DCOR/NaODC_candidate_DCOR-ai-review.yaml PTHR11482 PTN004264316 AN391 ok True PTN000159726 AN0 16 SPECIATION LUCA LUCA True True True 261 6 RGD:1564776|MGI:MGI:2442093|UniProtKB:Q96A70|MGI:MGI:97402|dictyBase:DDB_G0281109|RGD:3227 NaODC_candidate_ODC GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/NICAT/NaODC_candidate_ODC/NaODC_candidate_ODC-ai-review.yaml PTHR11482 PTN004264314 AN384 ok True PTN000159726 AN0 17 SPECIATION LUCA LUCA True True True 261 6 RGD:1564776|MGI:MGI:2442093|UniProtKB:Q96A70|MGI:MGI:97402|dictyBase:DDB_G0281109|RGD:3227 PMT1 GO:0004766 spermidine synthase activity molecular_function REMOVE genes/NICAT/NaPMT1.1/NaPMT1.1-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:O25503|UniProtKB:Q38EH6|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|SGD:S000006273|UniProtKB:P09158|MGI:MGI:102690|AGI_LocusCode:AT5G53120|UniProtKB:Q95Z84|AGI_LocusCode:AT1G23820|UniProtKB:Q9WZC2 PMT1 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/NICAT/NaPMT1.1/NaPMT1.1-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 3 UniProtKB:P09158|UniProtKB:Q8II73|MGI:MGI:102690 PMT1 GO:0008295 spermidine biosynthetic process biological_process REMOVE genes/NICAT/NaPMT1.1/NaPMT1.1-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:Q9WZC2|AGI_LocusCode:AT1G23820|dictyBase:DDB_G0268630|FB:FBgn0037723|SGD:S000006273|UniProtKB:P09158|UniProtKB:G5EAU1|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|UniProtKB:O25503|ZFIN:ZDB-GENE-040426-1183 PMT2 GO:0004766 spermidine synthase activity molecular_function REMOVE genes/NICAT/NaPMT1.2/NaPMT1.2-ai-review.yaml PTHR11558 PTN004269898 AN378 ok True PTN000168362 AN14 22 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:O25503|UniProtKB:Q38EH6|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|SGD:S000006273|UniProtKB:P09158|MGI:MGI:102690|AGI_LocusCode:AT5G53120|UniProtKB:Q95Z84|AGI_LocusCode:AT1G23820|UniProtKB:Q9WZC2 PMT2 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/NICAT/NaPMT1.2/NaPMT1.2-ai-review.yaml PTHR11558 PTN004269898 AN378 ok True PTN000168362 AN14 22 SPECIATION Eubacteria Eubacteria False False True 259 3 UniProtKB:P09158|UniProtKB:Q8II73|MGI:MGI:102690 PMT2 GO:0008295 spermidine biosynthetic process biological_process REMOVE genes/NICAT/NaPMT1.2/NaPMT1.2-ai-review.yaml PTHR11558 PTN004269898 AN378 ok True PTN000168362 AN14 22 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:Q9WZC2|AGI_LocusCode:AT1G23820|dictyBase:DDB_G0268630|FB:FBgn0037723|SGD:S000006273|UniProtKB:P09158|UniProtKB:G5EAU1|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|UniProtKB:O25503|ZFIN:ZDB-GENE-040426-1183 NaPMT3 GO:0004766 spermidine synthase activity molecular_function REMOVE genes/NICAT/NaPMT3/NaPMT3-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:O25503|UniProtKB:Q38EH6|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|SGD:S000006273|UniProtKB:P09158|MGI:MGI:102690|AGI_LocusCode:AT5G53120|UniProtKB:Q95Z84|AGI_LocusCode:AT1G23820|UniProtKB:Q9WZC2 NaPMT3 GO:0005829 cytosol cellular_component ACCEPT genes/NICAT/NaPMT3/NaPMT3-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 3 UniProtKB:P09158|UniProtKB:Q8II73|MGI:MGI:102690 NaPMT3 GO:0008295 spermidine biosynthetic process biological_process REMOVE genes/NICAT/NaPMT3/NaPMT3-ai-review.yaml PTHR11558 PTN004269893 AN377 ok True PTN000168362 AN14 21 SPECIATION Eubacteria Eubacteria False False True 259 12 UniProtKB:Q9WZC2|AGI_LocusCode:AT1G23820|dictyBase:DDB_G0268630|FB:FBgn0037723|SGD:S000006273|UniProtKB:P09158|UniProtKB:G5EAU1|UniProtKB:P19623|RGD:620796|AGI_LocusCode:AT1G70310|UniProtKB:O25503|ZFIN:ZDB-GENE-040426-1183 NaQPT2_candidate_QPT_0 GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/NICAT/NaQPT2_candidate_QPT_0/NaQPT2_candidate_QPT_0-ai-review.yaml PTHR32179 PTN004927531 AN141 no_same_term_ibd_on_path False NaQPT2_candidate_QPT_0 GO:0034213 quinolinate catabolic process biological_process ACCEPT genes/NICAT/NaQPT2_candidate_QPT_0/NaQPT2_candidate_QPT_0-ai-review.yaml PTHR32179 PTN004927531 AN141 ok True PTN000789406 AN0 17 SPECIATION LUCA LUCA True True True 137 1 UniProtKB:Q15274 NaQPT2_candidate_QPT_1 GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/NICAT/NaQPT2_candidate_QPT_1/NaQPT2_candidate_QPT_1-ai-review.yaml PTHR32179 PTN004927530 AN140 no_same_term_ibd_on_path False NaQPT2_candidate_QPT_1 GO:0034213 quinolinate catabolic process biological_process ACCEPT genes/NICAT/NaQPT2_candidate_QPT_1/NaQPT2_candidate_QPT_1-ai-review.yaml PTHR32179 PTN004927530 AN140 ok True PTN000789406 AN0 17 SPECIATION LUCA LUCA True True True 137 1 UniProtKB:Q15274 NaUGT1_candidate_UGT85A2_0 GO:0080043 quercetin 3-O-glucosyltransferase activity molecular_function UNDECIDED genes/NICAT/NaUGT1_candidate_UGT85A2_0/NaUGT1_candidate_UGT85A2_0-ai-review.yaml PTHR11926 PTN007550104 AN799 ok True PTN005361987 AN1 10 DUPLICATION Bryophyta-Tracheophyta True False True 2097 4 AGI_LocusCode:AT3G46670|AGI_LocusCode:AT5G59580|AGI_LocusCode:AT3G46660|AGI_LocusCode:AT5G59590 NaUGT1_candidate_UGT85A2_0 GO:0080044 quercetin 7-O-glucosyltransferase activity molecular_function UNDECIDED genes/NICAT/NaUGT1_candidate_UGT85A2_0/NaUGT1_candidate_UGT85A2_0-ai-review.yaml PTHR11926 PTN007550104 AN799 ok True PTN005361987 AN1 10 DUPLICATION Bryophyta-Tracheophyta True False True 2097 7 AGI_LocusCode:AT3G46670|AGI_LocusCode:AT2G43840|AGI_LocusCode:AT2G26480|AGI_LocusCode:AT2G23260|AGI_LocusCode:AT5G59590|AGI_LocusCode:AT3G46660|AGI_LocusCode:AT5G59580 AmiC1 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/NOSP7/AmiC1/AmiC1-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 AmiC2 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/NOSP7/AmiC2/AmiC2-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 AmiC1 GO:0030288 outer membrane-bounded periplasmic space cellular_component MODIFY genes/NOSS1/AmiC1/AmiC1-ai-review.yaml PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 AmiC2 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/NOSS1/AmiC2/AmiC2-ai-review.yaml PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 Saro_0802 GO:0010436 carotenoid dioxygenase activity molecular_function REMOVE genes/NOVAD/Saro_0802/Saro_0802-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 9 AGI_LocusCode:AT3G14440|AGI_LocusCode:AT3G24220|AGI_LocusCode:AT4G18350|AGI_LocusCode:AT3G63520|UniProtKB:P9WPR5|ZFIN:ZDB-GENE-010509-1|AGI_LocusCode:AT2G44990|FB:FBgn0002937|AGI_LocusCode:AT1G78390 Saro_0802 GO:0016121 carotene catabolic process biological_process MODIFY genes/NOVAD/Saro_0802/Saro_0802-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 10 AGI_LocusCode:AT3G63520|AGI_LocusCode:AT4G32810|MGI:MGI:2177469|MGI:MGI:1926923|UniProtKB:Q7XU29|UniProtKB:Q9BYV7|AGI_LocusCode:AT2G44990|UniProtKB:Q9HAY6|UniProtKB:Q8LIY8|AGI_LocusCode:AT4G19170 Saro_2809 GO:0010436 carotenoid dioxygenase activity molecular_function REMOVE genes/NOVAD/Saro_2809/Saro_2809-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 9 AGI_LocusCode:AT3G14440|AGI_LocusCode:AT3G24220|AGI_LocusCode:AT4G18350|AGI_LocusCode:AT3G63520|UniProtKB:P9WPR5|ZFIN:ZDB-GENE-010509-1|AGI_LocusCode:AT2G44990|FB:FBgn0002937|AGI_LocusCode:AT1G78390 Saro_2809 GO:0016121 carotene catabolic process biological_process MODIFY genes/NOVAD/Saro_2809/Saro_2809-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 10 AGI_LocusCode:AT3G63520|AGI_LocusCode:AT4G32810|MGI:MGI:2177469|MGI:MGI:1926923|UniProtKB:Q7XU29|UniProtKB:Q9BYV7|AGI_LocusCode:AT2G44990|UniProtKB:Q9HAY6|UniProtKB:Q8LIY8|AGI_LocusCode:AT4G19170 CTR1 GO:0032870 cellular response to hormone stimulus biological_process KEEP_AS_NON_CORE genes/OCTVU/CTR1/CTR1-ai-review.yaml PTHR24241 PTN001202415 AN131 ok True PTN001202348 AN5 2 SPECIATION Eumetazoa Eumetazoa True False True 730 1 RGD:2289 CTR1 GO:0042277 peptide binding molecular_function MODIFY genes/OCTVU/CTR1/CTR1-ai-review.yaml PTHR24241 PTN001202415 AN131 no_same_term_ibd_on_path False CTR2 GO:0032870 cellular response to hormone stimulus biological_process KEEP_AS_NON_CORE genes/OCTVU/CTR2/CTR2-ai-review.yaml PTHR24241 PTN001202415 AN131 ok True PTN001202348 AN5 2 SPECIATION Eumetazoa Eumetazoa True False True 730 1 RGD:2289 CTR2 GO:0042277 peptide binding molecular_function MODIFY genes/OCTVU/CTR2/CTR2-ai-review.yaml PTHR24241 PTN001202415 AN131 no_same_term_ibd_on_path False DDO GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/OCTVU/DDO/DDO-ai-review.yaml PTHR11530 PTN000898250 AN137 no_same_term_ibd_on_path False DDO GO:0019478 D-amino acid catabolic process biological_process ACCEPT genes/OCTVU/DDO/DDO-ai-review.yaml PTHR11530 PTN000898250 AN137 ok True PTN007512548 AN1 12 HORIZONTAL_TRANSFER Eubacteria False False True 129 9 UniProtKB:P31228|MGI:MGI:1925528|PomBase:SPCC1450.07c|UniProtKB:P00371|UniProtKB:P14920|RGD:1595123|MGI:MGI:94859|UniProtKB:Q99489|UniProtKB:A3KCL7 OCTS1 GO:0004364 glutathione transferase activity molecular_function MARK_AS_OVER_ANNOTATED genes/OCTVU/OCTS1/OCTS1-ai-review.yaml PTHR11571 PTN007515140 AN508 ok True PTN000170884 AN0 5 DUPLICATION True True 536 39 MGI:MGI:1309515|UniProtKB:O60760|UniProtKB:P21266|UniProtKB:P09211|ZFIN:ZDB-GENE-020806-4|MGI:MGI:95862|UniProtKB:C8V321|RGD:1593189|MGI:MGI:1309466|UniProtKB:Q8JFZ2|MGI:MGI:95861|ZFIN:ZDB-GENE-050601-1|UniProtKB:P20136|FB:FBgn0010226|MGI:MGI:95864|WB:WBGene00001752|ZFIN:ZDB-GENE-050309-24|UniProtKB:Q8ILQ7|UniProtKB:O15217|WB:WBGene00001749|UniProtKB:P46439|MGI:MGI:95863|WB:WBGene00001758|UniProtKB:Q03013|UniProtKB:O73888|UniProtKB:P28161|UniProtKB:P08263|ZFIN:ZDB-GENE-030911-2|RGD:69251|MGI:MGI:1095417|RGD:2754|MGI:MGI:95865|RGD:2756|MGI:MGI:95856|RGD:2753|RGD:61964|dictyBase:DDB_G0272632|UniProtKB:P09488|RGD:2755 OCTS1 GO:0006749 glutathione metabolic process biological_process MARK_AS_OVER_ANNOTATED genes/OCTVU/OCTS1/OCTS1-ai-review.yaml PTHR11571 PTN007515140 AN508 ok True PTN000170884 AN0 5 DUPLICATION True True 536 16 MGI:MGI:95865|RGD:2755|UniProtKB:O15217|UniProtKB:P09488|WB:WBGene00001752|MGI:MGI:95864|RGD:2756|FB:FBgn0010226|UniProtKB:P28161|UniProtKB:P21266|WB:WBGene00001758|UniProtKB:Q03013|UniProtKB:P46439|UniProtKB:Q8JFZ2|UniProtKB:P08263|UniProtKB:P09211 OPR GO:0032870 cellular response to hormone stimulus biological_process MODIFY genes/OCTVU/OPR/OPR-ai-review.yaml PTHR24241 PTN001202415 AN131 ok True PTN001202348 AN5 2 SPECIATION Eumetazoa Eumetazoa True False True 730 1 RGD:2289 OPR GO:0042277 peptide binding molecular_function MODIFY genes/OCTVU/OPR/OPR-ai-review.yaml PTHR24241 PTN001202415 AN131 no_same_term_ibd_on_path False TLN GO:0005178 integrin binding molecular_function ACCEPT genes/OSCPE/TLN/TLN-ai-review.yaml PTHR19981 PTN001072690 AN2 ok True PTN001072688 AN1 1 SPECIATION Opisthokonts Opisthokonts True False False 61 4 UniProtKB:Q9Y490|MGI:MGI:1099832|RGD:1306247|FB:FBgn0260442 TLN GO:0005737 cytoplasm cellular_component ACCEPT genes/OSCPE/TLN/TLN-ai-review.yaml PTHR19981 PTN001072690 AN2 ok True PTN000463398 AN0 2 SPECIATION Unikonts Unikonts True True False 70 4 UniProtKB:Q9Y490|UniProtKB:Q9Y4G6|dictyBase:DDB_G0287505|WB:WBGene00006771 TLN GO:0005886 plasma membrane cellular_component ACCEPT genes/OSCPE/TLN/TLN-ai-review.yaml PTHR19981 PTN001072690 AN2 ok True PTN000463398 AN0 2 SPECIATION Unikonts Unikonts True True False 70 2 WB:WBGene00006771|UniProtKB:Q9Y490 TLN GO:0030036 actin cytoskeleton organization biological_process KEEP_AS_NON_CORE genes/OSCPE/TLN/TLN-ai-review.yaml PTHR19981 PTN001072690 AN2 ok True PTN000463398 AN0 2 SPECIATION Unikonts Unikonts True True False 70 6 FB:FBgn0260442|dictyBase:DDB_G0287505|dictyBase:DDB_G0291303|ZFIN:ZDB-GENE-031002-48|MGI:MGI:1099832|UniProtKB:Q9Y4G6 TLN GO:0098609 cell-cell adhesion biological_process MODIFY genes/OSCPE/TLN/TLN-ai-review.yaml PTHR19981 PTN001072690 AN2 ok True PTN000463398 AN0 2 SPECIATION Unikonts Unikonts True True False 70 1 FB:FBgn0260442 AJ80_06654 GO:0016491 oxidoreductase activity molecular_function KEEP_AS_NON_CORE genes/POLH7/AJ80_06654/AJ80_06654-ai-review.yaml PTHR11709 PTN004294735 AN549 ok True PTN000194698 AN1 11 DUPLICATION False True 2401 25 UniProtKB:E9RBR0|FB:FBgn0052557|CGD:CAL0000183587|UniProtKB:P07788|SGD:S000004662|MGI:MGI:88476|AGI_LocusCode:AT5G60020|FB:FBgn0039387|UniProtKB:Q5B233|AGI_LocusCode:AT5G21100|AGI_LocusCode:AT2G38080|UniProtKB:Q6MZM0|AGI_LocusCode:AT1G23010|UniProtKB:P17489|UniProtKB:Q9BQS7|MGI:MGI:1332240|FB:FBgn0032116|PomBase:SPAC1F7.08|UniProtKB:Q5ARB0|AGI_LocusCode:AT1G71040|UniProtKB:Q5BEX9|UniProtKB:Q5BF02|SGD:S000001853|UniProtKB:P36649|UniProtKB:P00450 merA GO:0003955 NAD(P)H dehydrogenase (quinone) activity molecular_function REMOVE genes/PSEAI/merA/merA-ai-review.yaml PTHR43014 PTN005140324 AN13 ok True PTN002453100 AN1 4 SPECIATION LUCA LUCA True False False 29 1 UniProtKB:P9WHH7 PP_0094 GO:0004713 protein tyrosine kinase activity molecular_function REMOVE genes/PSEPK/PP_0094/PP_0094-ai-review.yaml PTHR43434 PTN002459616 AN73 ok True PTN001822758 AN58 3 SPECIATION Eubacteria Eubacteria True False False 9 1 UniProtKB:P9WPI9 PP_0094 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_0094/PP_0094-ai-review.yaml PTHR43434 PTN002459616 AN73 ok True PTN001291474 AN57 4 DUPLICATION LUCA True False True 80 1 UniProtKB:P32662 PP_0301 GO:0047617 fatty acyl-CoA hydrolase activity molecular_function MODIFY genes/PSEPK/PP_0301/PP_0301-ai-review.yaml PTHR31793 PTN002422169 AN89 ok True PTN001273712 AN0 5 SPECIATION LUCA LUCA True True True 212 2 UniProtKB:P77712|UniProtKB:Q55777 PP_0312 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/PP_0312/PP_0312-ai-review.yaml PTHR43153 PTN002249443 AN259 ok True PTN000097951 AN0 4 SPECIATION LUCA LUCA True True False 142 1 UniProtKB:P13804 PP_0416 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_0416/PP_0416-ai-review.yaml PTHR43434 PTN002459630 AN182 ok True PTN001291474 AN57 6 DUPLICATION LUCA True False True 80 1 UniProtKB:P32662 PP_0416 GO:0006281 DNA repair biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_0416/PP_0416-ai-review.yaml PTHR43434 PTN002459630 AN182 ok True PTN001052204 AN0 7 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 PP_0500 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/PP_0500/PP_0500-ai-review.yaml PTHR10491 PTN002236503 AN125 ok True PTN000051855 AN93 4 SPECIATION Eubacteria Eubacteria True False True 24 1 UniProtKB:P37760 PP_0581 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function ACCEPT genes/PSEPK/PP_0581/PP_0581-ai-review.yaml PTHR42760 PTN002449477 AN353 ok True PTN002449287 AN0 6 DUPLICATION True True 477 12 SGD:S000001538|CGD:CAL0000174204|MGI:MGI:95911|UniProtKB:Q8I2S7|UniProtKB:Q8N4T8|AGI_LocusCode:AT1G24360|UniProtKB:P37769|UniProtKB:P0AG84|UniProtKB:Q92506|UniProtKB:P05707|UniProtKB:P0AEK2|UniProtKB:P9WGT1 PP_0892 GO:0008808 cardiolipin synthase activity molecular_function UNDECIDED genes/PSEPK/PP_0892/PP_0892-ai-review.yaml PTHR21248 PTN002327321 AN93 ok True PTN000478698 AN0 7 SPECIATION LUCA LUCA True True True 66 5 UniProtKB:P45865|UniProtKB:P71040|UniProtKB:Q584D1|UniProtKB:P0AA84|UniProtKB:P0A6H8 PP_0892 GO:0016020 membrane cellular_component ACCEPT genes/PSEPK/PP_0892/PP_0892-ai-review.yaml PTHR21248 PTN002327321 AN93 ok True PTN000478704 AN85 4 SPECIATION Proteobacteria Proteobacteria True False True 18 2 UniProtKB:P0AA84|UniProtKB:P0A6H8 PP_0982 GO:0015920 lipopolysaccharide transport biological_process ACCEPT genes/PSEPK/PP_0982/PP_0982-ai-review.yaml PTHR33529 PTN002434455 AN34 ok True PTN002128445 AN2 5 DUPLICATION LUCA True False True 49 2 UniProtKB:P0ADC6|UniProtKB:P0AF98 PP_0983 GO:0015920 lipopolysaccharide transport biological_process ACCEPT genes/PSEPK/PP_0983/PP_0983-ai-review.yaml PTHR33529 PTN002434453 AN20 ok True PTN002128445 AN2 6 DUPLICATION LUCA True False True 49 2 UniProtKB:P0ADC6|UniProtKB:P0AF98 tsaA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_1084/PP_1084-ai-review.yaml PTHR10681 PTN002242136 AN587 ok True PTN000073874 AN0 6 SPECIATION LUCA LUCA True True True 325 9 UniProtKB:Q8IL80|FB:FBgn0040308|UniProtKB:Q13162|MGI:MGI:1859815|UniProtKB:P0AE08|FB:FBgn0040309|SGD:S000004490|UniProtKB:P32119|UniProtKB:P30048 tsaA GO:0008379 thioredoxin peroxidase activity molecular_function ACCEPT genes/PSEPK/PP_1084/PP_1084-ai-review.yaml PTHR10681 PTN002242136 AN587 ok True PTN000073874 AN0 6 SPECIATION LUCA LUCA True True True 325 6 UniProtKB:P32119|UniProtKB:P30048|UniProtKB:Q8I5Q6|UniProtKB:Q8IL80|PomBase:SPCC576.03c|UniProtKB:Q06830 tsaA GO:0033554 cellular response to stress biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_1084/PP_1084-ai-review.yaml PTHR10681 PTN002242136 AN587 no_same_term_ibd_on_path False tsaA GO:0042744 hydrogen peroxide catabolic process biological_process ACCEPT genes/PSEPK/PP_1084/PP_1084-ai-review.yaml PTHR10681 PTN002242136 AN587 ok True PTN000073874 AN0 6 SPECIATION LUCA LUCA True True True 325 10 UniProtKB:P0AE08|UniProtKB:Q06830|WB:WBGene00006434|FB:FBgn0040309|UniProtKB:P30048|MGI:MGI:109486|FB:FBgn0040308|PomBase:SPCC576.03c|UniProtKB:Q6ER94|FB:FBgn0038519 tsaA GO:0045454 cell redox homeostasis biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_1084/PP_1084-ai-review.yaml PTHR10681 PTN002242136 AN587 ok True PTN000073874 AN0 6 SPECIATION LUCA LUCA True True True 325 9 AGI_LocusCode:AT5G06290|PomBase:SPCC576.03c|MGI:MGI:1859815|UniProtKB:P9WQB7|FB:FBgn0038519|AGI_LocusCode:AT3G11630|SGD:S000004490|FB:FBgn0040309|SGD:S000002861 PP_1255 GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_1255/PP_1255-ai-review.yaml PTHR13847 PTN008552249 AN315 ok True PTN000354057 AN0 6 DUPLICATION True True 460 10 RGD:621125|FB:FBgn0002021|UniProtKB:Q9UI17|UniProtKB:O46504|UniProtKB:P33940|UniProtKB:Q5JFG7|UniProtKB:Q96CU9|MGI:MGI:2183102|UniProtKB:Q38A60|SGD:S000001051 PP_1257 GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity molecular_function REMOVE genes/PSEPK/PP_1257/PP_1257-ai-review.yaml PTHR12128 PTN002637266 AN396 ok True PTN000252718 AN73 4 SPECIATION LUCA LUCA True False True 230 4 AGI_LocusCode:AT2G45440|UniProtKB:P0A6L2|UniProtKB:P9WP25|AGI_LocusCode:AT3G60880 PP_1703 GO:0016020 membrane cellular_component REMOVE genes/PSEPK/PP_1703/PP_1703-ai-review.yaml PTHR43105 PTN000177398 AN168 ok True PTN008678681 AN8 1 DUPLICATION LUCA True False True 107 4 CGD:CAL0000186451|UniProtKB:P33602|UniProtKB:P09152|UniProtKB:P19319 PP_1907 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_1907/PP_1907-ai-review.yaml PTHR43434 PTN002459614 AN167 ok True PTN001291474 AN57 5 DUPLICATION LUCA True False True 80 1 UniProtKB:P32662 PP_1907 GO:0006281 DNA repair biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_1907/PP_1907-ai-review.yaml PTHR43434 PTN002459614 AN167 ok True PTN001052204 AN0 6 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 PP_1907 GO:0008967 phosphoglycolate phosphatase activity molecular_function ACCEPT genes/PSEPK/PP_1907/PP_1907-ai-review.yaml PTHR43434 PTN002459614 AN167 ok True PTN001052204 AN0 6 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 PP_1969 GO:0061798 GTP 3',8'-cyclase activity molecular_function UNDECIDED genes/PSEPK/PP_1969/PP_1969-ai-review.yaml PTHR22960 PTN008586333 AN233 ok True PTN000539172 AN6 3 SPECIATION LUCA LUCA True False False 141 3 MGI:MGI:1928904|UniProtKB:Q9NZB8|UniProtKB:P30745 PP_1969 GO:0061799 cyclic pyranopterin monophosphate synthase activity molecular_function REMOVE genes/PSEPK/PP_1969/PP_1969-ai-review.yaml PTHR22960 PTN008586333 AN233 ok True PTN000539172 AN6 3 SPECIATION LUCA LUCA True False False 141 2 MGI:MGI:1928904|UniProtKB:Q9NZB8 PP_2213 GO:0004321 fatty-acyl-CoA synthase activity molecular_function MODIFY genes/PSEPK/PP_2213/PP_2213-ai-review.yaml PTHR43605 PTN000644270 AN7 ok True PTN001944787 AN0 2 SPECIATION LUCA LUCA True True False 94 1 RGD:727928 PP_2213 GO:0006633 fatty acid biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_2213/PP_2213-ai-review.yaml PTHR43605 PTN000644270 AN7 ok True PTN001944787 AN0 2 SPECIATION LUCA LUCA True True False 94 2 MGI:MGI:2152200|MGI:MGI:99538 PP_2213 GO:0006637 acyl-CoA metabolic process biological_process ACCEPT genes/PSEPK/PP_2213/PP_2213-ai-review.yaml PTHR43605 PTN000644270 AN7 ok True PTN001944787 AN0 2 SPECIATION LUCA LUCA True True False 94 2 UniProtKB:Q08AH3|RGD:727928 PP_2213 GO:0015645 fatty acid ligase activity molecular_function ACCEPT genes/PSEPK/PP_2213/PP_2213-ai-review.yaml PTHR43605 PTN000644270 AN7 ok True PTN001944787 AN0 2 SPECIATION LUCA LUCA True True False 94 8 UniProtKB:Q08AH3|UniProtKB:Q08AH1|RGD:727928|UniProtKB:Q53FZ2|MGI:MGI:2152200|UniProtKB:Q9BEA2|UniProtKB:Q68CK6|MGI:MGI:99538 PP_2320 GO:0005576 extracellular region cellular_component MODIFY genes/PSEPK/PP_2320/PP_2320-ai-review.yaml PTHR30582 PTN002412830 AN41 ok True PTN001255072 AN0 5 DUPLICATION True True 70 1 UniProtKB:P0AAX8 PP_2320 GO:0018104 peptidoglycan-protein cross-linking biological_process ACCEPT genes/PSEPK/PP_2320/PP_2320-ai-review.yaml PTHR30582 PTN002412830 AN41 ok True PTN001255072 AN0 5 DUPLICATION True True 70 4 UniProtKB:O53638|UniProtKB:P0AAX8|UniProtKB:P39176|UniProtKB:P75954 PP_2320 GO:0071972 peptidoglycan L,D-transpeptidase activity molecular_function ACCEPT genes/PSEPK/PP_2320/PP_2320-ai-review.yaml PTHR30582 PTN002412830 AN41 ok True PTN001255072 AN0 5 DUPLICATION True True 70 5 UniProtKB:P75954|UniProtKB:P76193|UniProtKB:P0AAX8|UniProtKB:O53638|UniProtKB:P39176 PP_2325 GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/PP_2325/PP_2325-ai-review.yaml PTHR21708 PTN002330878 AN114 ok True PTN000496347 AN0 5 SPECIATION LUCA LUCA True True True 62 1 SGD:S000004044 PP_2482 GO:0061798 GTP 3',8'-cyclase activity molecular_function UNDECIDED genes/PSEPK/PP_2482/PP_2482-ai-review.yaml PTHR22960 PTN008586334 AN235 ok True PTN000539172 AN6 4 SPECIATION LUCA LUCA True False False 141 3 MGI:MGI:1928904|UniProtKB:Q9NZB8|UniProtKB:P30745 PP_2482 GO:0061799 cyclic pyranopterin monophosphate synthase activity molecular_function REMOVE genes/PSEPK/PP_2482/PP_2482-ai-review.yaml PTHR22960 PTN008586334 AN235 ok True PTN000539172 AN6 4 SPECIATION LUCA LUCA True False False 141 2 MGI:MGI:1928904|UniProtKB:Q9NZB8 PP_2528 GO:0004124 cysteine synthase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/PP_2528/PP_2528-ai-review.yaml PTHR43797 PTN002887252 AN66 no_same_term_ibd_on_path False PP_2528 GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/PP_2528/PP_2528-ai-review.yaml PTHR43797 PTN002887252 AN66 ok True PTN002887184 AN0 4 SPECIATION LUCA LUCA True True True 41 1 PomBase:SPBC428.11 PP_2528 GO:0071269 L-homocysteine biosynthetic process biological_process UNDECIDED genes/PSEPK/PP_2528/PP_2528-ai-review.yaml PTHR43797 PTN002887252 AN66 ok True PTN002887184 AN0 4 SPECIATION LUCA LUCA True True True 41 2 PomBase:SPBC428.11|SGD:S000004294 PP_2608 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/PP_2608/PP_2608-ai-review.yaml PTHR21089 PTN001078614 AN337 ok True PTN001464795 AN283 4 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 PP_2608 GO:0009423 chorismate biosynthetic process biological_process REMOVE genes/PSEPK/PP_2608/PP_2608-ai-review.yaml PTHR21089 PTN001078614 AN337 ok True PTN000472519 AN0 5 SPECIATION LUCA LUCA True True True 191 2 UniProtKB:P15770|UniProtKB:O67049 PP_2608 GO:0019632 shikimate metabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/PP_2608/PP_2608-ai-review.yaml PTHR21089 PTN001078614 AN337 ok True PTN000472519 AN0 5 SPECIATION LUCA LUCA True True True 191 3 AGI_LocusCode:AT3G06350|UniProtKB:O67049|UniProtKB:P15770 PP_2608 GO:0050661 NADP binding molecular_function MODIFY genes/PSEPK/PP_2608/PP_2608-ai-review.yaml PTHR21089 PTN001078614 AN337 no_same_term_ibd_on_path False PP_2998 GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/PP_2998/PP_2998-ai-review.yaml PTHR21708 PTN000496377 AN110 ok True PTN000496347 AN0 5 SPECIATION LUCA LUCA True True True 62 1 SGD:S000004044 PP_3117 GO:0006281 DNA repair biological_process MODIFY genes/PSEPK/PP_3117/PP_3117-ai-review.yaml PTHR35369 PTN009155960 AN10 ok True PTN002176549 AN0 3 DUPLICATION True True 16 1 UniProtKB:O50419 PP_3157 GO:0042578 phosphoric ester hydrolase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/PP_3157/PP_3157-ai-review.yaml PTHR43200 PTN005150789 AN468 ok True PTN002456026 AN0 2 SPECIATION LUCA LUCA True True False 299 8 AGI_LocusCode:AT5G64000|PomBase:SPCC1753.04|UniProtKB:C4M4T9|AGI_LocusCode:AT4G39120|AGI_LocusCode:AT5G63980|UniProtKB:Q9K4B1|AGI_LocusCode:AT5G54390|SGD:S000005425 PP_3199 GO:0004497 monooxygenase activity molecular_function ACCEPT genes/PSEPK/PP_3199/PP_3199-ai-review.yaml PTHR13789 PTN007623892 AN158 ok True PTN002492679 AN0 3 SPECIATION LUCA LUCA True True True 104 1 UniProtKB:Q9HWG9 PP_3303 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/PP_3303/PP_3303-ai-review.yaml PTHR11712 PTN002620071 AN746 ok True PTN000196483 AN682 2 SPECIATION Eubacteria Eubacteria True False True 67 2 UniProtKB:P9WQD9|UniProtKB:P0A953 PP_3394 GO:0004419 hydroxymethylglutaryl-CoA lyase activity molecular_function UNDECIDED genes/PSEPK/PP_3394/PP_3394-ai-review.yaml PTHR42738 PTN000031316 AN19 ok True PTN000031222 AN0 4 SPECIATION LUCA LUCA True True True 183 7 RGD:620554|UniProtKB:Q8TB92|AGI_LocusCode:AT2G26800|UniProtKB:P35914|MGI:MGI:96158|UniProtKB:P35915|UniProtKB:Q9I2A0 PP_3394 GO:0006552 L-leucine catabolic process biological_process UNDECIDED genes/PSEPK/PP_3394/PP_3394-ai-review.yaml PTHR42738 PTN000031316 AN19 ok True PTN000031222 AN0 4 SPECIATION LUCA LUCA True True True 183 3 UniProtKB:Q9I2A0|MGI:MGI:96158|UniProtKB:Q5B2F7 PP_3394 GO:0046951 ketone body biosynthetic process biological_process UNDECIDED genes/PSEPK/PP_3394/PP_3394-ai-review.yaml PTHR42738 PTN000031316 AN19 ok True PTN000031222 AN0 4 SPECIATION LUCA LUCA True True True 183 5 UniProtKB:P35914|UniProtKB:P35915|FB:FBgn0031877|UniProtKB:Q8TB92|RGD:620554 PP_3571 GO:0008777 acetylornithine deacetylase activity molecular_function UNDECIDED genes/PSEPK/PP_3571/PP_3571-ai-review.yaml PTHR43808 PTN002465950 AN270 ok True PTN000865743 AN227 5 SPECIATION Eubacteria Eubacteria True False True 29 2 UniProtKB:Q8P8J5|UniProtKB:P23908 PP_3599 GO:0008840 4-hydroxy-tetrahydrodipicolinate synthase activity molecular_function REMOVE genes/PSEPK/PP_3599/PP_3599-ai-review.yaml PTHR12128 PTN001740851 AN414 ok True PTN000252718 AN73 3 SPECIATION LUCA LUCA True False True 230 4 AGI_LocusCode:AT2G45440|UniProtKB:P0A6L2|UniProtKB:P9WP25|AGI_LocusCode:AT3G60880 PP_3768 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/PP_3768/PP_3768-ai-review.yaml PTHR21089 PTN001843603 AN284 ok True PTN001464795 AN283 1 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 PP_3768 GO:0009423 chorismate biosynthetic process biological_process ACCEPT genes/PSEPK/PP_3768/PP_3768-ai-review.yaml PTHR21089 PTN001843603 AN284 ok True PTN000472519 AN0 2 SPECIATION LUCA LUCA True True True 191 2 UniProtKB:P15770|UniProtKB:O67049 PP_3768 GO:0019632 shikimate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/PP_3768/PP_3768-ai-review.yaml PTHR21089 PTN001843603 AN284 ok True PTN000472519 AN0 2 SPECIATION LUCA LUCA True True True 191 3 AGI_LocusCode:AT3G06350|UniProtKB:O67049|UniProtKB:P15770 PP_3768 GO:0050661 NADP binding molecular_function ACCEPT genes/PSEPK/PP_3768/PP_3768-ai-review.yaml PTHR21089 PTN001843603 AN284 no_same_term_ibd_on_path False PP_3995 GO:1990228 sulfurtransferase complex cellular_component ACCEPT genes/PSEPK/PP_3995/PP_3995-ai-review.yaml PTHR37526 PTN002444813 AN6 ok True PTN002206503 AN0 2 SPECIATION Eubacteria Eubacteria True True False 8 1 UniProtKB:P45530 PP_4379 GO:0044550 secondary metabolite biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/PP_4379/PP_4379-ai-review.yaml PTHR34069 PTN002147079 AN17 ok True PTN002147059 AN0 6 SPECIATION LUCA LUCA True True True 30 1 UniProtKB:Q9I4X1 PP_4545 GO:0044550 secondary metabolite biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/PP_4545/PP_4545-ai-review.yaml PTHR34069 PTN002436757 AN47 ok True PTN002147059 AN0 5 SPECIATION LUCA LUCA True True True 30 1 UniProtKB:Q9I4X1 PP_4594 GO:0004123 cystathionine gamma-lyase activity molecular_function UNDECIDED genes/PSEPK/PP_4594/PP_4594-ai-review.yaml PTHR11808 PTN000211591 AN177 ok True PTN000211591 AN177 0 SPECIATION LUCA LUCA True False False 109 6 UniProtKB:P32929|SGD:S000000010|UniProtKB:C8VM61|UniProtKB:O05394|MGI:MGI:1339968|UniProtKB:P9WGB7 PP_4594 GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/PP_4594/PP_4594-ai-review.yaml PTHR11808 PTN000211591 AN177 ok True PTN000211590 AN0 1 DUPLICATION True True 295 6 MGI:MGI:1339968|SGD:S000003152|SGD:S000001154|AGI_LocusCode:AT1G64660|UniProtKB:Q38DH3|AGI_LocusCode:AT3G57050 PP_4594 GO:0016846 carbon-sulfur lyase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/PP_4594/PP_4594-ai-review.yaml PTHR11808 PTN000211591 AN177 ok True PTN000211590 AN0 1 DUPLICATION True True 295 10 AGI_LocusCode:AT1G64660|UniProtKB:C8VM61|UniProtKB:O05394|UniProtKB:Q5AXC9|UniProtKB:P32929|UniProtKB:P9WGB7|SGD:S000003152|MGI:MGI:1339968|AGI_LocusCode:AT3G57050|SGD:S000000010 PP_4638 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/PP_4638/PP_4638-ai-review.yaml PTHR45754 PTN000472732 AN284 ok True PTN000472667 AN0 1 SPECIATION LUCA LUCA True True False 175 1 MGI:MGI:106639 PP_4638 GO:0071949 FAD binding molecular_function ACCEPT genes/PSEPK/PP_4638/PP_4638-ai-review.yaml PTHR45754 PTN000472732 AN284 ok True PTN000472667 AN0 1 SPECIATION LUCA LUCA True True False 175 1 UniProtKB:P0AEZ1 PP_5298 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/PP_5298/PP_5298-ai-review.yaml PTHR43235 PTN000938594 AN208 no_same_term_ibd_on_path False PP_5298 GO:0006598 polyamine catabolic process biological_process MODIFY genes/PSEPK/PP_5298/PP_5298-ai-review.yaml PTHR43235 PTN000938594 AN208 ok True PTN000230196 AN185 2 SPECIATION Eubacteria Eubacteria True False False 17 2 UniProtKB:Q9I6J4|UniProtKB:P76038 accD GO:0009329 acetate CoA-transferase complex cellular_component ACCEPT genes/PSEPK/accD/accD-ai-review.yaml PTHR42995 PTN002452836 AN118 ok True PTN000523527 AN108 2 SPECIATION Proteobacteria Proteobacteria True False False 12 1 UniProtKB:P0A9Q5 aceF GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/aceF/aceF-ai-review.yaml PTHR43178 PTN002455742 AN330 no_same_term_ibd_on_path False aceF GO:0016407 acetyltransferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/aceF/aceF-ai-review.yaml PTHR43178 PTN002455742 AN330 no_same_term_ibd_on_path False aceF GO:0031405 lipoic acid binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/aceF/aceF-ai-review.yaml PTHR43178 PTN002455742 AN330 no_same_term_ibd_on_path False aceK GO:0004721 phosphoprotein phosphatase activity molecular_function ACCEPT genes/PSEPK/aceK/aceK-ai-review.yaml PTHR39559 PTN002446796 AN4 no_same_term_ibd_on_path False aceK GO:0016208 AMP binding molecular_function ACCEPT genes/PSEPK/aceK/aceK-ai-review.yaml PTHR39559 PTN002446796 AN4 no_same_term_ibd_on_path False acoA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity molecular_function REMOVE genes/PSEPK/acoA/acoA-ai-review.yaml PTHR11516 PTN002264059 AN17 ok True PTN008519424 AN0 7 SPECIATION LUCA LUCA True True True 293 5 RGD:620095|UniProtKB:P29803|SGD:S000000980|UniProtKB:P29804|UniProtKB:Q5B2R8 acoA GO:0006086 pyruvate decarboxylation to acetyl-CoA biological_process REMOVE genes/PSEPK/acoA/acoA-ai-review.yaml PTHR11516 PTN002264059 AN17 ok True PTN008519424 AN0 7 SPECIATION LUCA LUCA True True True 293 6 UniProtKB:P08559|SGD:S000000980|MGI:MGI:97532|RGD:3286|RGD:620095|UniProtKB:P29803 acpP GO:0000035 acyl binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/acpP/acpP-ai-review.yaml PTHR20863 PTN001074738 AN554 ok True PTN000466551 AN0 4 SPECIATION LUCA LUCA True True True 318 2 UniProtKB:P0A6A8|UniProtKB:P9WQF3 acpP GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/acpP/acpP-ai-review.yaml PTHR20863 PTN001074738 AN554 ok True PTN000466714 AN478 3 SPECIATION Eubacteria Eubacteria True False True 64 1 UniProtKB:P0A6A8 acpP GO:0009245 lipid A biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/acpP/acpP-ai-review.yaml PTHR20863 PTN001074738 AN554 ok True PTN000466714 AN478 3 SPECIATION Eubacteria Eubacteria True False True 64 1 UniProtKB:P0A6A8 acsA1 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/acsA1/acsA1-ai-review.yaml PTHR24095 PTN002378820 AN417 ok True PTN000644276 AN385 4 SPECIATION Eubacteria Eubacteria True False True 27 1 UniProtKB:P27550 acsA2 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/acsA2/acsA2-ai-review.yaml PTHR24095 PTN002378818 AN426 ok True PTN000644276 AN385 5 SPECIATION Eubacteria Eubacteria True False True 27 1 UniProtKB:P27550 ahcY GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/ahcY/ahcY-ai-review.yaml PTHR23420 PTN002361476 AN466 ok True PTN000602759 AN0 4 SPECIATION LUCA LUCA True True False 255 4 UniProtKB:P23526|MGI:MGI:2385184|MGI:MGI:1921590|MGI:MGI:87968 ahcY GO:0033353 L-methionine cycle biological_process ACCEPT genes/PSEPK/ahcY/ahcY-ai-review.yaml PTHR23420 PTN002361476 AN466 ok True PTN000602759 AN0 4 SPECIATION LUCA LUCA True True False 255 4 ZFIN:ZDB-GENE-031219-6|FB:FBgn0014455|FB:FBgn0035371|SGD:S000000845 ahpC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/ahpC/ahpC-ai-review.yaml PTHR10681 PTN000074135 AN555 ok True PTN000073874 AN0 4 SPECIATION LUCA LUCA True True True 325 9 UniProtKB:Q8IL80|FB:FBgn0040308|UniProtKB:Q13162|MGI:MGI:1859815|UniProtKB:P0AE08|FB:FBgn0040309|SGD:S000004490|UniProtKB:P32119|UniProtKB:P30048 ahpC GO:0008379 thioredoxin peroxidase activity molecular_function MODIFY genes/PSEPK/ahpC/ahpC-ai-review.yaml PTHR10681 PTN000074135 AN555 ok True PTN000073874 AN0 4 SPECIATION LUCA LUCA True True True 325 6 UniProtKB:P32119|UniProtKB:P30048|UniProtKB:Q8I5Q6|UniProtKB:Q8IL80|PomBase:SPCC576.03c|UniProtKB:Q06830 ahpC GO:0033554 cellular response to stress biological_process ACCEPT genes/PSEPK/ahpC/ahpC-ai-review.yaml PTHR10681 PTN000074135 AN555 no_same_term_ibd_on_path False ahpC GO:0042744 hydrogen peroxide catabolic process biological_process ACCEPT genes/PSEPK/ahpC/ahpC-ai-review.yaml PTHR10681 PTN000074135 AN555 ok True PTN000073874 AN0 4 SPECIATION LUCA LUCA True True True 325 10 UniProtKB:P0AE08|UniProtKB:Q06830|WB:WBGene00006434|FB:FBgn0040309|UniProtKB:P30048|MGI:MGI:109486|FB:FBgn0040308|PomBase:SPCC576.03c|UniProtKB:Q6ER94|FB:FBgn0038519 ahpC GO:0045454 cell redox homeostasis biological_process ACCEPT genes/PSEPK/ahpC/ahpC-ai-review.yaml PTHR10681 PTN000074135 AN555 ok True PTN000073874 AN0 4 SPECIATION LUCA LUCA True True True 325 9 AGI_LocusCode:AT5G06290|PomBase:SPCC576.03c|MGI:MGI:1859815|UniProtKB:P9WQB7|FB:FBgn0038519|AGI_LocusCode:AT3G11630|SGD:S000004490|FB:FBgn0040309|SGD:S000002861 alaS GO:0002161 aminoacyl-tRNA deacylase activity molecular_function ACCEPT genes/PSEPK/alaS/alaS-ai-review.yaml PTHR11777 PTN002272811 AN475 ok True PTN000206950 AN0 4 SPECIATION LUCA LUCA True True False 260 4 UniProtKB:P49588|UniProtKB:Q57984|UniProtKB:P00957|MGI:MGI:2384560 alaS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/alaS/alaS-ai-review.yaml PTHR11777 PTN002272811 AN475 ok True PTN000207063 AN329 3 SPECIATION Eubacteria Eubacteria True False False 86 1 UniProtKB:P00957 alaS GO:0045892 negative regulation of DNA-templated transcription biological_process UNDECIDED genes/PSEPK/alaS/alaS-ai-review.yaml PTHR11777 PTN002272811 AN475 no_same_term_ibd_on_path False alg8 GO:0030213 hyaluronan biosynthetic process biological_process REMOVE genes/PSEPK/alg8/alg8-ai-review.yaml PTHR22913 PTN002740694 AN163 ok True PTN000530809 AN0 3 SPECIATION LUCA LUCA True True False 86 7 RGD:2781|MGI:MGI:107821|MGI:MGI:106590|UniProtKB:Q92819|UniProtKB:O00219|MGI:MGI:109599|UniProtKB:Q92839 alg8 GO:0050501 hyaluronan synthase activity molecular_function REMOVE genes/PSEPK/alg8/alg8-ai-review.yaml PTHR22913 PTN002740694 AN163 ok True PTN000530809 AN0 3 SPECIATION LUCA LUCA True True False 86 7 UniProtKB:O00219|MGI:MGI:106590|UniProtKB:Q92819|UniProtKB:P13563|RGD:2781|MGI:MGI:109599|MGI:MGI:107821 alg8 GO:0085029 extracellular matrix assembly biological_process KEEP_AS_NON_CORE genes/PSEPK/alg8/alg8-ai-review.yaml PTHR22913 PTN002740694 AN163 ok True PTN000530809 AN0 3 SPECIATION LUCA LUCA True True False 86 3 MGI:MGI:107821|MGI:MGI:109599|MGI:MGI:106590 alr GO:0005829 cytosol cellular_component REMOVE genes/PSEPK/alr/alr-ai-review.yaml PTHR30511 PTN002021362 AN77 ok True PTN000775508 AN0 7 SPECIATION LUCA LUCA True True True 51 1 UniProtKB:P29012 alr GO:0030632 D-alanine biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/alr/alr-ai-review.yaml PTHR30511 PTN002021362 AN77 ok True PTN001253738 AN19 5 SPECIATION Eubacteria Eubacteria True False True 40 2 UniProtKB:P9WQA9|UniProtKB:P0A6B4 amaC GO:0004838 L-tyrosine:2-oxoglutarate transaminase activity molecular_function ACCEPT genes/PSEPK/amaC/amaC-ai-review.yaml PTHR11879 PTN001725705 AN759 ok True PTN000222931 AN753 3 DUPLICATION Eubacteria True False True 16 2 UniProtKB:P00509|UniProtKB:P04693 amaC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/amaC/amaC-ai-review.yaml PTHR11879 PTN001725705 AN759 ok True PTN000222931 AN753 3 DUPLICATION Eubacteria True False True 16 1 UniProtKB:P04693 amaC GO:0042802 identical protein binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/amaC/amaC-ai-review.yaml PTHR11879 PTN001725705 AN759 ok True PTN000222929 AN748 4 SPECIATION Eubacteria Eubacteria True False True 19 2 UniProtKB:P00509|UniProtKB:P04693 ampD GO:0009254 peptidoglycan turnover biological_process ACCEPT genes/PSEPK/ampD/ampD-ai-review.yaml PTHR30417 PTN002411577 AN37 ok True PTN001252273 AN0 5 SPECIATION LUCA LUCA True True True 37 1 UniProtKB:P13016 argD GO:0042802 identical protein binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/argD/argD-ai-review.yaml PTHR11986 PTN002279553 AN498 no_same_term_ibd_on_path False argF GO:0019240 L-citrulline biosynthetic process biological_process ACCEPT genes/PSEPK/argF/argF-ai-review.yaml PTHR45753 PTN002261302 AN344 ok True PTN000150424 AN62 5 SPECIATION LUCA LUCA True False True 157 4 RGD:3236|UniProtKB:P06960|UniProtKB:P00480|UniProtKB:P04391 argG GO:0000050 urea cycle biological_process REMOVE genes/PSEPK/argG/argG-ai-review.yaml PTHR11587 PTN002266045 AN120 ok True PTN000172504 AN0 7 SPECIATION LUCA LUCA True True False 162 2 UniProtKB:P00966|RGD:2163 argH GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/argH/argH-ai-review.yaml PTHR43814 PTN002466110 AN265 ok True PTN000154674 AN0 4 SPECIATION LUCA LUCA True True False 147 1 SGD:S000001060 argJ GO:0006592 L-ornithine biosynthetic process biological_process ACCEPT genes/PSEPK/argJ/argJ-ai-review.yaml PTHR23100 PTN002349843 AN168 ok True PTN000559455 AN0 3 SPECIATION LUCA LUCA True True False 92 2 UniProtKB:Q5AVF8|SGD:S000004666 aroC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/aroC/aroC-ai-review.yaml PTHR21085 PTN002326142 AN221 ok True PTN000472417 AN0 5 SPECIATION LUCA LUCA True True False 126 2 UniProtKB:P12008|UniProtKB:C6KT66 aroC GO:0010181 FMN binding molecular_function ACCEPT genes/PSEPK/aroC/aroC-ai-review.yaml PTHR21085 PTN002326142 AN221 no_same_term_ibd_on_path False aroE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/aroE/aroE-ai-review.yaml PTHR21089 PTN007685418 AN319 ok True PTN001464795 AN283 3 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 aroE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/aroE__Q88IJ7/aroE__Q88IJ7-ai-review.yaml PTHR21089 PTN007685418 AN319 ok True PTN001464795 AN283 3 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 aroE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/aroE__Q88K85/aroE__Q88K85-ai-review.yaml PTHR21089 PTN002721176 AN342 ok True PTN001464795 AN283 4 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 aroE GO:0019632 shikimate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/aroE__Q88K85/aroE__Q88K85-ai-review.yaml PTHR21089 PTN002721176 AN342 ok True PTN000472519 AN0 5 SPECIATION LUCA LUCA True True True 191 3 AGI_LocusCode:AT3G06350|UniProtKB:O67049|UniProtKB:P15770 aroE GO:0050661 NADP binding molecular_function ACCEPT genes/PSEPK/aroE__Q88K85/aroE__Q88K85-ai-review.yaml PTHR21089 PTN002721176 AN342 no_same_term_ibd_on_path False aroE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/aroE__Q88RQ5/aroE__Q88RQ5-ai-review.yaml PTHR21089 PTN002326172 AN329 ok True PTN001464795 AN283 6 DUPLICATION LUCA True False True 41 1 UniProtKB:P15770 aroF-I GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/aroF-I/aroF-I-ai-review.yaml PTHR21225 PTN002327028 AN83 ok True PTN000476971 AN0 5 SPECIATION LUCA LUCA True True True 64 2 UniProtKB:P0AB91|UniProtKB:P00887 aroF-II GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/aroF-II/aroF-II-ai-review.yaml PTHR21225 PTN002327031 AN104 ok True PTN000476971 AN0 6 SPECIATION LUCA LUCA True True True 64 2 UniProtKB:P0AB91|UniProtKB:P00887 aroK GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/aroK/aroK-ai-review.yaml PTHR21087 PTN002326157 AN401 ok True PTN000472457 AN0 4 SPECIATION LUCA LUCA True True False 222 1 UniProtKB:P0A6D7 aroQ-III GO:0019631 quinate catabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/aroQ-III/aroQ-III-ai-review.yaml PTHR21272 PTN000479790 AN0 ok True PTN000479790 AN0 0 SPECIATION Eubacteria Eubacteria True True False 33 1 UniProtKB:P05147 aroQ1 GO:0019631 quinate catabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/aroQ1/aroQ1-ai-review.yaml PTHR21272 PTN002327525 AN50 ok True PTN000479790 AN0 5 SPECIATION Eubacteria Eubacteria True True True 33 1 UniProtKB:P05147 aroQ2 GO:0019631 quinate catabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/aroQ2/aroQ2-ai-review.yaml PTHR21272 PTN002327524 AN49 ok True PTN000479790 AN0 5 SPECIATION Eubacteria Eubacteria True True True 33 1 UniProtKB:P05147 aruC GO:0042802 identical protein binding molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/aruC/aruC-ai-review.yaml PTHR11986 PTN002279542 AN489 no_same_term_ibd_on_path False astE GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function KEEP_AS_NON_CORE genes/PSEPK/astE/astE-ai-review.yaml PTHR15162 PTN002309601 AN4 ok True PTN001032245 AN1 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P76215 bcsA GO:0016758 hexosyltransferase activity molecular_function MODIFY genes/PSEPK/bcsA/bcsA-ai-review.yaml PTHR43867 PTN001634554 AN93 ok True PTN002466726 AN0 4 SPECIATION LUCA LUCA True True True 56 2 dictyBase:DDB_G0269124|UniProtKB:P74165 benB GO:0019380 3-phenylpropionate catabolic process biological_process REMOVE genes/PSEPK/benB/benB-ai-review.yaml PTHR41534 PTN002447682 AN10 ok True PTN002222817 AN0 3 SPECIATION Proteobacteria Proteobacteria True True True 6 1 UniProtKB:Q47140 benD GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor molecular_function MODIFY genes/PSEPK/benD/benD-ai-review.yaml PTHR42760 PTN002460465 AN619 ok True PTN002449287 AN0 7 DUPLICATION True True 477 12 SGD:S000001538|CGD:CAL0000174204|MGI:MGI:95911|UniProtKB:Q8I2S7|UniProtKB:Q8N4T8|AGI_LocusCode:AT1G24360|UniProtKB:P37769|UniProtKB:P0AG84|UniProtKB:Q92506|UniProtKB:P05707|UniProtKB:P0AEK2|UniProtKB:P9WGT1 benD GO:0030497 fatty acid elongation biological_process REMOVE genes/PSEPK/benD/benD-ai-review.yaml PTHR42760 PTN002460465 AN619 ok True PTN001211919 AN369 4 SPECIATION Eubacteria Eubacteria True False True 179 2 UniProtKB:P0AEK2|UniProtKB:P0A2C9 betA GO:0016020 membrane cellular_component ACCEPT genes/PSEPK/betA/betA-ai-review.yaml PTHR11552 PTN002610944 AN418 ok True PTN001694860 AN413 3 SPECIATION Viridiplantae Viridiplantae False False False 7 1 UniProtKB:P17444 betA GO:0016491 oxidoreductase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/betA/betA-ai-review.yaml PTHR11552 PTN002610944 AN418 ok True PTN000167771 AN0 9 SPECIATION LUCA LUCA True True False 259 5 FB:FBgn0030597|FB:FBgn0037896|RGD:735166|UniProtKB:Q4WCK6|UniProtKB:P17444 betC GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/betC/betC-ai-review.yaml PTHR45953 PTN002233290 AN79 no_same_term_ibd_on_path False betC GO:0008484 sulfuric ester hydrolase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/betC/betC-ai-review.yaml PTHR45953 PTN002233290 AN79 ok True PTN000038764 AN0 5 SPECIATION LUCA LUCA True True False 67 5 FB:FBgn0035445|MGI:MGI:96417|ZFIN:ZDB-GENE-061215-37|UniProtKB:P22304|UniProtKB:Q6MX51 bglX GO:0009251 glucan catabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/bglX/bglX-ai-review.yaml PTHR30620 PTN000770763 AN705 ok True PTN000770732 AN0 3 SPECIATION LUCA LUCA True True True 421 1 UniProtKB:Q5BCC6 bhbP GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/bhbP/bhbP-ai-review.yaml PTHR30354 PTN002411262 AN12 ok True PTN000769104 AN0 4 SPECIATION LUCA LUCA True True True 42 7 UniProtKB:P0AC94|UniProtKB:P08555|UniProtKB:P39835|UniProtKB:Q46892|UniProtKB:P39357|UniProtKB:P0AC96|UniProtKB:P39344 bioB GO:0051537 2 iron, 2 sulfur cluster binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/bioB/bioB-ai-review.yaml PTHR22976 PTN004591108 AN173 ok True PTN000540961 AN0 5 SPECIATION LUCA LUCA True True False 100 1 UniProtKB:P12996 bioD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/bioD/bioD-ai-review.yaml PTHR43210 PTN002456225 AN29 ok True PTN000482092 AN0 4 SPECIATION LUCA LUCA True True True 41 1 UniProtKB:P13000 carB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/carB/carB-ai-review.yaml PTHR11405 PTN002261332 AN468 ok True PTN000150222 AN0 6 DUPLICATION True True 359 18 UniProtKB:Q57U84|UniProtKB:P22572|SGD:S000005829|UniProtKB:Q7SH52|SGD:S000003666|AGI_LocusCode:AT1G29900|RGD:2395|UniProtKB:P31327|UniProtKB:P0A786|UniProtKB:P00968|UniProtKB:P0A6F1|PomBase:SPBC215.08c|AGI_LocusCode:AT3G27740|MGI:MGI:891996|UniProtKB:P27708|PomBase:SPBC56F2.09c|UniProtKB:Q57U86|SGD:S000003870 carB GO:0006541 L-glutamine metabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/carB/carB-ai-review.yaml PTHR11405 PTN002261332 AN468 ok True PTN000150223 AN1 5 SPECIATION LUCA LUCA True False True 251 1 dictyBase:DDB_G0276335 catR GO:0032993 protein-DNA complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/catR/catR-ai-review.yaml PTHR30346 PTN002411085 AN62 ok True PTN001576272 AN2 5 DUPLICATION False True 110 2 UniProtKB:Q9K1H8|UniProtKB:Q9HTL4 cbcW GO:0005275 amine transmembrane transporter activity molecular_function REMOVE genes/PSEPK/cbcW/cbcW-ai-review.yaml PTHR47737 PTN002410106 AN17 ok True PTN000766131 AN0 4 SPECIATION Eubacteria Eubacteria True True True 13 2 UniProtKB:Q9HTI7|UniProtKB:P14176 cbcW GO:0015226 carnitine transmembrane transporter activity molecular_function REMOVE genes/PSEPK/cbcW/cbcW-ai-review.yaml PTHR47737 PTN002410106 AN17 ok True PTN000766131 AN0 4 SPECIATION Eubacteria Eubacteria True True True 13 1 UniProtKB:Q9HTI7 cbcW GO:0015871 choline transport biological_process ACCEPT genes/PSEPK/cbcW/cbcW-ai-review.yaml PTHR47737 PTN002410106 AN17 ok True PTN000766131 AN0 4 SPECIATION Eubacteria Eubacteria True True True 13 1 UniProtKB:Q9HTI7 cbcW GO:1902603 carnitine transmembrane transport biological_process ACCEPT genes/PSEPK/cbcW/cbcW-ai-review.yaml PTHR47737 PTN002410106 AN17 ok True PTN000766131 AN0 4 SPECIATION Eubacteria Eubacteria True True True 13 1 UniProtKB:Q9HTI7 ccmB GO:1903607 cytochrome c biosynthetic process biological_process ACCEPT genes/PSEPK/ccmB/ccmB-ai-review.yaml PTHR30070 PTN002409350 AN65 ok True PTN001247807 AN0 4 SPECIATION LUCA LUCA True True False 44 1 UniProtKB:P0ABL8 ccmD GO:1903607 cytochrome c biosynthetic process biological_process ACCEPT genes/PSEPK/ccmD/ccmD-ai-review.yaml PTHR37531 PTN002444815 AN5 ok True PTN002206561 AN0 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True True False 8 1 UniProtKB:P0ABM5 ccmH GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/ccmH/ccmH-ai-review.yaml PTHR47870 PTN002408846 AN20 ok True PTN002936361 AN2 2 DUPLICATION Eubacteria True False True 15 1 UniProtKB:P0ABM9 chrR GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/chrR/chrR-ai-review.yaml PTHR30543 PTN004743948 AN247 ok True PTN001254275 AN0 20 SPECIATION LUCA LUCA True True True 167 2 SGD:S000004001|UniProtKB:P0AGE6 chrR GO:0010181 FMN binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/chrR/chrR-ai-review.yaml PTHR30543 PTN004743948 AN247 no_same_term_ibd_on_path False clpB GO:0034605 cellular response to heat biological_process ACCEPT genes/PSEPK/clpB/clpB-ai-review.yaml PTHR11638 PTN002267826 AN822 ok True PTN000181243 AN0 7 SPECIATION LUCA LUCA True True True 483 7 SGD:S000003949|dictyBase:DDB_G0291314|UniProtKB:Q9H078|UniProtKB:Q6F2Y7|CGD:CAL0000200274|SGD:S000002666|PomBase:SPBC16D10.08c clpV GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/clpV/clpV-ai-review.yaml PTHR11638 PTN005170413 AN788 ok True PTN000181243 AN0 4 SPECIATION LUCA LUCA True True True 483 14 UniProtKB:Q75GT3|UniProtKB:Q8IB03|UniProtKB:Q8IM28|PomBase:SPBC16D10.08c|UniProtKB:P0ABH9|UniProtKB:Q0E3C8|UniProtKB:P63284|SGD:S000003949|AGI_LocusCode:AT2G25140|UniProtKB:Q9H078|UniProtKB:Q587G1|SGD:S000002666|UniProtKB:Q586B8|AGI_LocusCode:AT5G15450 clpV GO:0034605 cellular response to heat biological_process REMOVE genes/PSEPK/clpV/clpV-ai-review.yaml PTHR11638 PTN005170413 AN788 ok True PTN000181243 AN0 4 SPECIATION LUCA LUCA True True True 483 7 SGD:S000003949|dictyBase:DDB_G0291314|UniProtKB:Q9H078|UniProtKB:Q6F2Y7|CGD:CAL0000200274|SGD:S000002666|PomBase:SPBC16D10.08c clpX GO:0009376 HslUV protease complex cellular_component MODIFY genes/PSEPK/clpX/clpX-ai-review.yaml PTHR48102 PTN002258935 AN475 ok True PTN000137358 AN435 3 SPECIATION Eubacteria Eubacteria True False False 33 1 UniProtKB:P0A6H1 clpX GO:0051301 cell division biological_process KEEP_AS_NON_CORE genes/PSEPK/clpX/clpX-ai-review.yaml PTHR48102 PTN002258935 AN475 ok True PTN000137358 AN435 3 SPECIATION Eubacteria Eubacteria True False False 33 2 UniProtKB:P9WPB9|UniProtKB:P0A6H1 clsA GO:0016020 membrane cellular_component KEEP_AS_NON_CORE genes/PSEPK/clsA/clsA-ai-review.yaml PTHR21248 PTN002327329 AN107 ok True PTN000478704 AN85 4 SPECIATION Proteobacteria Proteobacteria True False True 18 2 UniProtKB:P0AA84|UniProtKB:P0A6H8 clsB GO:0016020 membrane cellular_component KEEP_AS_NON_CORE genes/PSEPK/clsB/clsB-ai-review.yaml PTHR21248 PTN002327327 AN94 ok True PTN000478704 AN85 4 SPECIATION Proteobacteria Proteobacteria True False True 18 2 UniProtKB:P0AA84|UniProtKB:P0A6H8 colR GO:0000156 phosphorelay response regulator activity molecular_function ACCEPT genes/PSEPK/colR/colR-ai-review.yaml PTHR48111 PTN002403572 AN185 ok True PTN000724188 AN0 8 SPECIATION LUCA LUCA True True True 475 10 UniProtKB:P0AE88|UniProtKB:P0AA16|UniProtKB:P30843|UniProtKB:Q9I2U3|UniProtKB:P0A9Q1|UniProtKB:Q8DPL7|UniProtKB:Q8DN02|UniProtKB:O07776|UniProtKB:P36556|UniProtKB:P38684 colR GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/colR/colR-ai-review.yaml PTHR48111 PTN002403572 AN185 ok True PTN000724188 AN0 8 SPECIATION LUCA LUCA True True True 475 4 UniProtKB:P69228|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P0AE88 colR GO:0032993 protein-DNA complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/colR/colR-ai-review.yaml PTHR48111 PTN002403572 AN185 ok True PTN000724188 AN0 8 SPECIATION LUCA LUCA True True True 475 6 UniProtKB:Q8EE50|UniProtKB:P26275|UniProtKB:P0A9Q1|UniProtKB:P23836|UniProtKB:Q8EHJ3|UniProtKB:O24973 cycH GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/cycH/cycH-ai-review.yaml PTHR47870 PTN002288918 AN11 ok True PTN002936361 AN2 2 DUPLICATION Eubacteria True False True 15 1 UniProtKB:P0ABM9 cysS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/cysS/cysS-ai-review.yaml PTHR10890 PTN002248472 AN499 ok True PTN000095420 AN451 3 SPECIATION Eubacteria Eubacteria True False False 37 1 UniProtKB:P21888 dacB GO:0000270 peptidoglycan metabolic process biological_process ACCEPT genes/PSEPK/dacB/dacB-ai-review.yaml PTHR30023 PTN002408896 AN26 ok True PTN000768632 AN0 5 SPECIATION LUCA LUCA True True False 20 2 UniProtKB:Q9HZG1|UniProtKB:P24228 dadX GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/dadX/dadX-ai-review.yaml PTHR30511 PTN002412235 AN74 ok True PTN000775508 AN0 7 SPECIATION LUCA LUCA True True True 51 1 UniProtKB:P29012 dapA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dapA__Q88NH2/dapA__Q88NH2-ai-review.yaml PTHR12128 PTN002281418 AN473 ok True PTN000252839 AN422 4 SPECIATION Eubacteria Eubacteria True False True 42 1 UniProtKB:P0A6L2 dapB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dapB/dapB-ai-review.yaml PTHR20836 PTN002324624 AN276 ok True PTN000464634 AN233 3 SPECIATION Eubacteria Eubacteria True False False 33 1 UniProtKB:P04036 dapE GO:0006526 L-arginine biosynthetic process biological_process REMOVE genes/PSEPK/dapE/dapE-ai-review.yaml PTHR43808 PTN002887524 AN258 ok True PTN000865743 AN227 3 SPECIATION Eubacteria Eubacteria True False False 29 1 UniProtKB:P23908 dapE GO:0008777 acetylornithine deacetylase activity molecular_function REMOVE genes/PSEPK/dapE/dapE-ai-review.yaml PTHR43808 PTN002887524 AN258 ok True PTN000865743 AN227 3 SPECIATION Eubacteria Eubacteria True False False 29 2 UniProtKB:Q8P8J5|UniProtKB:P23908 dapF GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dapF__Q88CF3/dapF__Q88CF3-ai-review.yaml PTHR31689 PTN002420849 AN165 ok True PTN000784354 AN129 4 SPECIATION Eubacteria Eubacteria True False False 29 1 UniProtKB:P0A6K1 dapF GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dapF__Q88GD4/dapF__Q88GD4-ai-review.yaml PTHR31689 PTN001271294 AN148 ok True PTN000784354 AN129 2 SPECIATION Eubacteria Eubacteria True False False 29 1 UniProtKB:P0A6K1 davA GO:0050126 N-carbamoylputrescine amidase activity molecular_function REMOVE genes/PSEPK/davA/davA-ai-review.yaml PTHR43674 PTN001132736 AN247 ok True PTN000557706 AN237 3 SPECIATION Eubacteria Eubacteria True False True 74 2 UniProtKB:Q9I6J8|AGI_LocusCode:AT2G27450 davD GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity molecular_function REMOVE genes/PSEPK/davD/davD-ai-review.yaml PTHR43353 PTN002458567 AN206 ok True PTN008681047 AN18 10 SPECIATION Terrabacteria Terrabacteria False False False 162 7 RGD:621422|UniProtKB:P51649|MGI:MGI:2441982|UniProtKB:P25526|AGI_LocusCode:AT1G79440|SGD:S000000210|FB:FBgn0039349 davD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/davD/davD-ai-review.yaml PTHR43353 PTN002458567 AN206 ok True PTN000192659 AN200 2 SPECIATION Proteobacteria Proteobacteria True False False 8 1 UniProtKB:P25553 davT GO:0042802 identical protein binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/davT/davT-ai-review.yaml PTHR11986 PTN002633741 AN9 no_same_term_ibd_on_path False ddlA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ddlA/ddlA-ai-review.yaml PTHR23132 PTN000566195 AN135 ok True PTN008591310 AN116 1 SPECIATION Eubacteria Eubacteria True False False 19 1 UniProtKB:P0A6J8 dfp GO:0071513 phosphopantothenoylcysteine decarboxylase complex cellular_component ACCEPT genes/PSEPK/dfp/dfp-ai-review.yaml PTHR14359 PTN002307105 AN376 ok True PTN000372091 AN0 4 SPECIATION LUCA LUCA True True False 217 5 SGD:S000001780|SGD:S000005580|SGD:S000001571|AGI_LocusCode:AT3G18030|UniProtKB:Q96CD2 dgcB GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/dgcB/dgcB-ai-review.yaml PTHR43255 PTN002456823 AN55 no_same_term_ibd_on_path False dinB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dinB/dinB-ai-review.yaml PTHR11076 PTN002253950 AN270 no_same_term_ibd_on_path False dinB GO:0042276 error-prone translesion synthesis biological_process ACCEPT genes/PSEPK/dinB/dinB-ai-review.yaml PTHR11076 PTN002253950 AN270 ok True PTN000117876 AN0 5 SPECIATION LUCA LUCA True True True 153 3 UniProtKB:Q9UBT6|WB:WBGene00017696|UniProtKB:Q47155 dnaA GO:0005886 plasma membrane cellular_component KEEP_AS_NON_CORE genes/PSEPK/dnaA/dnaA-ai-review.yaml PTHR30050 PTN002409084 AN144 ok True PTN000769352 AN81 4 SPECIATION Eubacteria Eubacteria True False True 47 4 UniProtKB:P9WNW3|UniProtKB:P69931|UniProtKB:O26057|UniProtKB:P03004 dnaA GO:0006260 DNA replication biological_process ACCEPT genes/PSEPK/dnaA/dnaA-ai-review.yaml PTHR30050 PTN002409084 AN144 no_same_term_ibd_on_path False dnaB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/dnaB/dnaB-ai-review.yaml PTHR30153 PTN002409948 AN60 ok True PTN000765491 AN6 3 SPECIATION Eubacteria Eubacteria True False False 40 1 UniProtKB:P0ACB0 dnaG GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/dnaG/dnaG-ai-review.yaml PTHR30313 PTN002410857 AN59 ok True PTN001250916 AN0 4 SPECIATION LUCA LUCA True True False 44 1 UniProtKB:P0ABS5 dnaJ GO:0042026 protein refolding biological_process ACCEPT genes/PSEPK/dnaJ/dnaJ-ai-review.yaml PTHR43096 PTN002454563 AN893 ok True PTN002454318 AN0 5 SPECIATION LUCA LUCA True True True 482 2 UniProtKB:P08622|SGD:S000001878 dnaN GO:0006271 DNA strand elongation involved in DNA replication biological_process ACCEPT genes/PSEPK/dnaN/dnaN-ai-review.yaml PTHR30478 PTN002412008 AN51 ok True PTN000767221 AN0 3 SPECIATION Eubacteria Eubacteria True True False 39 1 UniProtKB:P0A988 dnaQ GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/dnaQ/dnaQ-ai-review.yaml PTHR30231 PTN002410414 AN359 ok True PTN001249947 AN266 7 DUPLICATION LUCA True False True 63 1 UniProtKB:P30014 dnaQ GO:0008408 3'-5' exonuclease activity molecular_function ACCEPT genes/PSEPK/dnaQ/dnaQ-ai-review.yaml PTHR30231 PTN002410414 AN359 ok True PTN001249948 AN0 8 SPECIATION LUCA LUCA True True True 210 2 UniProtKB:P30014|UniProtKB:P0AEK0 dnaQ GO:0045004 DNA replication proofreading biological_process ACCEPT genes/PSEPK/dnaQ/dnaQ-ai-review.yaml PTHR30231 PTN002410414 AN359 ok True PTN001249959 AN296 6 SPECIATION Eubacteria Eubacteria True False True 46 1 UniProtKB:P03007 dnaX GO:0006261 DNA-templated DNA replication biological_process ACCEPT genes/PSEPK/dnaX/dnaX-ai-review.yaml PTHR11669 PTN002268855 AN1515 ok True PTN000186208 AN0 5 SPECIATION LUCA LUCA True True True 803 14 PomBase:SPBC83.14c|SGD:S000005454|UniProtKB:P28631|PomBase:SPAC1687.03c|UniProtKB:P06710|SGD:S000005234|UniProtKB:P40938|SGD:S000000291|UniProtKB:P35249|SGD:S000003829|UniProtKB:P40937|PomBase:SPAC23D3.02|UniProtKB:P35250|PomBase:SPAC27E2.10c dxr GO:0030145 manganese ion binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/dxr/dxr-ai-review.yaml PTHR30525 PTN002412343 AN172 no_same_term_ibd_on_path False dxs GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/dxs/dxs-ai-review.yaml PTHR43322 PTN002457875 AN376 ok True PTN000179250 AN332 4 DUPLICATION LUCA True False True 33 1 UniProtKB:P77488 dxs GO:0016744 transketolase or transaldolase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/dxs/dxs-ai-review.yaml PTHR43322 PTN002457875 AN376 ok True PTN000179225 AN0 5 SPECIATION LUCA LUCA True True True 207 3 UniProtKB:P77488|AGI_LocusCode:AT4G15560|UniProtKB:P9WNS3 ech GO:0008300 isoprenoid catabolic process biological_process MODIFY genes/PSEPK/ech/ech-ai-review.yaml PTHR42964 PTN002873559 AN18 no_same_term_ibd_on_path False edd GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/edd/edd-ai-review.yaml PTHR43661 PTN002462738 AN39 ok True PTN000470254 AN0 5 SPECIATION LUCA LUCA True True True 40 1 UniProtKB:P05791 eutB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/eutB/eutB-ai-review.yaml PTHR39329 PTN002446606 AN7 ok True PTN002217393 AN0 3 SPECIATION Eubacteria Eubacteria True True False 7 1 UniProtKB:P0AEJ6 exbB GO:0017038 protein import biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/exbB/exbB-ai-review.yaml PTHR30625 PTN004746214 AN15 no_same_term_ibd_on_path False fabB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/fabB/fabB-ai-review.yaml PTHR11712 PTN002270989 AN741 ok True PTN000196483 AN682 5 SPECIATION Eubacteria Eubacteria True False True 67 2 UniProtKB:P9WQD9|UniProtKB:P0A953 fabD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/fabD/fabD-ai-review.yaml PTHR42681 PTN005125768 AN149 ok True PTN000104976 AN97 4 SPECIATION Eubacteria Eubacteria True False True 41 1 UniProtKB:P0AAI9 fabD GO:0006633 fatty acid biosynthetic process biological_process ACCEPT genes/PSEPK/fabD/fabD-ai-review.yaml PTHR42681 PTN005125768 AN149 ok True PTN002448244 AN0 5 SPECIATION LUCA LUCA True True True 90 5 AGI_LocusCode:AT2G30200|UniProtKB:Q8IVS2|UniProtKB:P9WNG5|UniProtKB:P0AAI9|UniProtKB:G3XCZ6 fabF GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/fabF/fabF-ai-review.yaml PTHR11712 PTN004296092 AN772 ok True PTN000196483 AN682 5 SPECIATION Eubacteria Eubacteria True False True 67 2 UniProtKB:P9WQD9|UniProtKB:P0A953 fabV GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/fabV/fabV-ai-review.yaml PTHR37480 PTN002206130 AN6 ok True PTN002206122 AN0 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True True False 7 2 UniProtKB:Q9KRA3|UniProtKB:Q9HZP8 fadA GO:0010124 phenylacetate catabolic process biological_process REMOVE genes/PSEPK/fadA__Q88L01/fadA__Q88L01-ai-review.yaml PTHR43853 PTN002466592 AN350 no_same_term_ibd_on_path False fadB GO:0016509 long-chain (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity molecular_function ACCEPT genes/PSEPK/fadB/fadB-ai-review.yaml PTHR43612 PTN002462037 AN13 ok True PTN000592895 AN0 3 SPECIATION LUCA LUCA True True False 67 3 MGI:MGI:2135593|UniProtKB:P40939|RGD:620512 fadE GO:0005737 cytoplasm cellular_component UNDECIDED genes/PSEPK/fadE/fadE-ai-review.yaml PTHR48083 PTN002466402 AN632 ok True PTN002535634 AN0 8 DUPLICATION True True 351 13 UniProtKB:Q47146|RGD:2012|UniProtKB:P11310|RGD:1306270|MGI:MGI:87866|UniProtKB:Q6JQN1|FB:FBgn0086712|FB:FBgn0035811|UniProtKB:P60584|MGI:MGI:2143169|UniProtKB:Q709F0|MGI:MGI:87867|RGD:2011 fau GO:0009396 folic acid-containing compound biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fau/fau-ai-review.yaml PTHR23407 PTN002361263 AN313 no_same_term_ibd_on_path False fau GO:0035999 tetrahydrofolate interconversion biological_process ACCEPT genes/PSEPK/fau/fau-ai-review.yaml PTHR23407 PTN002361263 AN313 ok True PTN000601268 AN0 4 SPECIATION LUCA LUCA True True False 173 1 UniProtKB:P49914 fbp GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/fbp/fbp-ai-review.yaml PTHR11556 PTN002265199 AN714 ok True PTN000168152 AN699 3 SPECIATION Eubacteria Eubacteria True False False 15 1 UniProtKB:P0A993 fbp GO:0005986 sucrose biosynthetic process biological_process REMOVE genes/PSEPK/fbp/fbp-ai-review.yaml PTHR11556 PTN002265199 AN714 no_same_term_ibd_on_path False fbp GO:0006000 fructose metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fbp/fbp-ai-review.yaml PTHR11556 PTN002265199 AN714 no_same_term_ibd_on_path False fbp GO:0006002 fructose 6-phosphate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fbp/fbp-ai-review.yaml PTHR11556 PTN002265199 AN714 no_same_term_ibd_on_path False fbp GO:0030388 fructose 1,6-bisphosphate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fbp/fbp-ai-review.yaml PTHR11556 PTN002265199 AN714 no_same_term_ibd_on_path False fcs GO:0006631 fatty acid metabolic process biological_process MODIFY genes/PSEPK/fcs/fcs-ai-review.yaml PTHR43201 PTN008449823 AN234 ok True PTN000644517 AN0 5 SPECIATION LUCA LUCA True True True 358 2 WB:WBGene00009221|AGI_LocusCode:AT3G16170 fcs GO:0031956 medium-chain fatty acid-CoA ligase activity molecular_function MODIFY genes/PSEPK/fcs/fcs-ai-review.yaml PTHR43201 PTN008449823 AN234 ok True PTN000644517 AN0 5 SPECIATION LUCA LUCA True True True 358 1 UniProtKB:Q96CM8 fdx GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/fdx/fdx-ai-review.yaml PTHR23426 PTN001918369 AN660 ok True PTN002361620 AN656 2 SPECIATION Proteobacteria Proteobacteria True False False 9 1 UniProtKB:P0A9R4 fdx GO:0022900 electron transport chain biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/fdx/fdx-ai-review.yaml PTHR23426 PTN001918369 AN660 ok True PTN002511924 AN0 4 SPECIATION Eubacteria Eubacteria True True False 354 4 UniProtKB:P00257|AGI_LocusCode:AT3G07480|AGI_LocusCode:AT4G05450|AGI_LocusCode:AT3G16250 flgE GO:0005829 cytosol cellular_component REMOVE genes/PSEPK/flgE/flgE-ai-review.yaml PTHR30435 PTN000764868 AN142 ok True PTN000764859 AN129 2 SPECIATION Eubacteria Eubacteria True False False 17 1 UniProtKB:P75937 flgE GO:0009424 bacterial-type flagellum hook cellular_component ACCEPT genes/PSEPK/flgE/flgE-ai-review.yaml PTHR30435 PTN000764868 AN142 ok True PTN000764859 AN129 2 SPECIATION Eubacteria Eubacteria True False False 17 1 UniProtKB:P75937 flgE GO:0071978 bacterial-type flagellum-dependent swarming motility biological_process KEEP_AS_NON_CORE genes/PSEPK/flgE/flgE-ai-review.yaml PTHR30435 PTN000764868 AN142 ok True PTN000764839 AN2 3 DUPLICATION False True 119 4 UniProtKB:P24501|UniProtKB:P39752|UniProtKB:P24500|UniProtKB:P23446 flgG GO:0071978 bacterial-type flagellum-dependent swarming motility biological_process KEEP_AS_NON_CORE genes/PSEPK/flgG/flgG-ai-review.yaml PTHR30435 PTN002411673 AN91 ok True PTN000764839 AN2 5 DUPLICATION False True 119 4 UniProtKB:P24501|UniProtKB:P39752|UniProtKB:P24500|UniProtKB:P23446 fliD GO:0071973 bacterial-type flagellum-dependent cell motility biological_process KEEP_AS_NON_CORE genes/PSEPK/fliD/fliD-ai-review.yaml PTHR30288 PTN008624504 AN21 ok True PTN000767631 AN0 3 SPECIATION Eubacteria Eubacteria True True False 22 2 UniProtKB:P96786|UniProtKB:P24216 fliI GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function REMOVE genes/PSEPK/fliI/fliI-ai-review.yaml PTHR15184 PTN002309653 AN37 ok True PTN008558586 AN4 5 DUPLICATION LUCA True False True 330 4 UniProtKB:P0ABB4|PomBase:SPAC222.12c|SGD:S000003882|UniProtKB:P06576 fmt GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/fmt/fmt-ai-review.yaml PTHR11138 PTN002255760 AN253 ok True PTN000124171 AN201 3 SPECIATION Eubacteria Eubacteria True False False 39 1 UniProtKB:P23882 folD1 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/folD1/folD1-ai-review.yaml PTHR48099 PTN002224732 AN727 ok True PTN000002250 AN0 3 SPECIATION LUCA LUCA True True False 389 5 UniProtKB:P11586|UniProtKB:P24186|MGI:MGI:1342005|UniProtKB:Q4Q9F9|SGD:S000001788 folD2 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/folD2/folD2-ai-review.yaml PTHR48099 PTN002224733 AN734 ok True PTN000002250 AN0 4 SPECIATION LUCA LUCA True True False 389 5 UniProtKB:P11586|UniProtKB:P24186|MGI:MGI:1342005|UniProtKB:Q4Q9F9|SGD:S000001788 fpr-I GO:0034599 cellular response to oxidative stress biological_process UNDECIDED genes/PSEPK/fpr-I/fpr-I-ai-review.yaml PTHR47878 PTN001064622 AN20 no_same_term_ibd_on_path False fpr-I GO:0042167 heme catabolic process biological_process UNDECIDED genes/PSEPK/fpr-I/fpr-I-ai-review.yaml PTHR47878 PTN001064622 AN20 ok True PTN002500048 AN6 4 DUPLICATION Eubacteria True False True 13 1 UniProtKB:Q9HYK7 fpvA GO:0015344 siderophore uptake transmembrane transporter activity molecular_function ACCEPT genes/PSEPK/fpvA/fpvA-ai-review.yaml PTHR32552 PTN002427916 AN37 ok True PTN000793005 AN7 5 SPECIATION Eubacteria Eubacteria True False True 68 3 UniProtKB:Q9I116|UniProtKB:P75780|UniProtKB:P06971 frmA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/frmA/frmA-ai-review.yaml PTHR43880 PTN002466975 AN1264 ok True PTN000191653 AN0 4 SPECIATION LUCA LUCA True True False 709 6 UniProtKB:P00325|UniProtKB:P25437|UniProtKB:P40394|UniProtKB:P07327|MGI:MGI:87921|UniProtKB:P00326 frmC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/frmC/frmC-ai-review.yaml PTHR10061 PTN002225577 AN226 ok True PTN000006872 AN0 6 SPECIATION LUCA LUCA True True True 124 2 UniProtKB:P10768|SGD:S000003604 fruA GO:0090563 protein-phosphocysteine-sugar phosphotransferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/fruA/fruA-ai-review.yaml PTHR30505 PTN002412130 AN46 ok True PTN002021020 AN0 3 DUPLICATION True True 37 2 UniProtKB:P54745|UniProtKB:P20966 fruK GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/fruK/fruK-ai-review.yaml PTHR46566 PTN002238739 AN54 ok True PTN001317471 AN6 3 DUPLICATION LUCA True False True 31 1 UniProtKB:P06999 ftsY GO:0005047 signal recognition particle binding molecular_function ACCEPT genes/PSEPK/ftsY/ftsY-ai-review.yaml PTHR43134 PTN002455079 AN441 ok True PTN000169915 AN0 5 SPECIATION LUCA LUCA True True True 246 1 SGD:S000002700 ftsY GO:0006605 protein targeting biological_process MODIFY genes/PSEPK/ftsY/ftsY-ai-review.yaml PTHR43134 PTN002455079 AN441 ok True PTN000169915 AN0 5 SPECIATION LUCA LUCA True True True 246 2 SGD:S000002700|UniProtKB:P10121 fumC GO:0006108 malate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fumC/fumC-ai-review.yaml PTHR11444 PTN002262547 AN282 ok True PTN000154499 AN17 4 SPECIATION LUCA LUCA True False False 148 3 AGI_LocusCode:AT2G47510|UniProtKB:P07954|AGI_LocusCode:AT5G50950 fur GO:0000976 transcription cis-regulatory region binding molecular_function ACCEPT genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112386 AN0 6 SPECIATION LUCA LUCA True True True 83 15 UniProtKB:Q8Y5U9|UniProtKB:Q03456|UniProtKB:P54479|UniProtKB:P71086|UniProtKB:P0A0S8|UniProtKB:P0A9A9|UniProtKB:H7C6K3|UniProtKB:Q89VW1|UniProtKB:Q8PAL3|UniProtKB:P0AC51|UniProtKB:P9WN85|UniProtKB:Q7CQY3|UniProtKB:Q9L2H5|UniProtKB:P33086|UniProtKB:P54574 fur GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112441 AN37 4 SPECIATION Eubacteria Eubacteria True False True 30 1 UniProtKB:P0A9A9 fur GO:0008270 zinc ion binding molecular_function MODIFY genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112386 AN0 6 SPECIATION LUCA LUCA True True True 83 2 UniProtKB:P9WN85|UniProtKB:P0A9A9 fur GO:0045892 negative regulation of DNA-templated transcription biological_process ACCEPT genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112386 AN0 6 SPECIATION LUCA LUCA True True True 83 16 UniProtKB:Q7BR72|UniProtKB:P54574|UniProtKB:Q8EFN3|UniProtKB:Q9JZ70|UniProtKB:P33086|UniProtKB:Q9L2H5|UniProtKB:P74739|UniProtKB:P9WN85|UniProtKB:Q8PAL3|UniProtKB:P0A9A9|UniProtKB:Q89VW1|UniProtKB:P0A0S8|UniProtKB:Q9HT74|UniProtKB:Q8Y5U9|UniProtKB:Q03456|UniProtKB:P54479 fur GO:1900376 regulation of secondary metabolite biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112386 AN0 6 SPECIATION LUCA LUCA True True True 83 2 UniProtKB:Q9HT74|UniProtKB:Q03456 fur GO:1900705 negative regulation of siderophore biosynthetic process biological_process ACCEPT genes/PSEPK/fur/fur-ai-review.yaml PTHR33202 PTN002431809 AN75 ok True PTN002112483 AN65 2 SPECIATION Proteobacteria Proteobacteria True False False 12 1 UniProtKB:Q03456 gabD-II GO:0004777 succinate-semialdehyde dehydrogenase (NAD+) activity molecular_function UNDECIDED genes/PSEPK/gabD-II/gabD-II-ai-review.yaml PTHR43353 PTN008681047 AN18 ok True PTN008681047 AN18 0 SPECIATION Terrabacteria Terrabacteria False False False 162 7 RGD:621422|UniProtKB:P51649|MGI:MGI:2441982|UniProtKB:P25526|AGI_LocusCode:AT1G79440|SGD:S000000210|FB:FBgn0039349 gabD-II GO:0009450 GABA catabolic process biological_process UNDECIDED genes/PSEPK/gabD-II/gabD-II-ai-review.yaml PTHR43353 PTN008681047 AN18 ok True PTN008681047 AN18 0 SPECIATION Terrabacteria Terrabacteria False False False 162 3 SGD:S000000210|UniProtKB:P51649|UniProtKB:P25526 galB GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides molecular_function REMOVE genes/PSEPK/galB/galB-ai-review.yaml PTHR12993 PTN001770600 AN248 ok True PTN000313004 AN0 5 SPECIATION LUCA LUCA True True True 161 7 UniProtKB:Q6F4N1|RGD:620437|UniProtKB:P9WJN1|UniProtKB:Q9Y2B2|UniProtKB:P9WJN3|SGD:S000004894|UniProtKB:Q382X3 galE GO:0033499 beta-D-galactose catabolic process via UDP-galactose, Leloir pathway biological_process REMOVE genes/PSEPK/galE/galE-ai-review.yaml PTHR43725 PTN008684687 AN248 no_same_term_ibd_on_path False galR GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/galR/galR-ai-review.yaml PTHR30419 PTN002019180 AN84 ok True PTN000790637 AN0 7 DUPLICATION True True 58 1 UniProtKB:P0ACR7 garD GO:0019698 D-galacturonate catabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/garD/garD-ai-review.yaml PTHR30536 PTN002021951 AN14 no_same_term_ibd_on_path False gatC GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation biological_process UNDECIDED genes/PSEPK/gatC/gatC-ai-review.yaml PTHR15004 PTN001805850 AN217 ok True PTN000385050 AN0 3 SPECIATION LUCA LUCA True True False 117 1 UniProtKB:O43716 gbd GO:0004022 alcohol dehydrogenase (NAD+) activity molecular_function MODIFY genes/PSEPK/gbd/gbd-ai-review.yaml PTHR11496 PTN008519236 AN225 ok True PTN002608572 AN0 5 SPECIATION LUCA LUCA True True True 131 7 PomBase:SPAC5H10.06c|SGD:S000003225|UniProtKB:Q24803|UniProtKB:P76553|UniProtKB:P37686|UniProtKB:Q9XDN0|UniProtKB:P0A9Q7 gcl GO:0005948 acetolactate synthase complex cellular_component REMOVE genes/PSEPK/gcl/gcl-ai-review.yaml PTHR18968 PTN002317630 AN100 ok True PTN000438758 AN17 5 SPECIATION LUCA LUCA True False True 237 3 UniProtKB:P08142|SGD:S000004714|UniProtKB:P00893 gcl GO:0009099 L-valine biosynthetic process biological_process REMOVE genes/PSEPK/gcl/gcl-ai-review.yaml PTHR18968 PTN002317630 AN100 ok True PTN000438758 AN17 5 SPECIATION LUCA LUCA True False True 237 6 UniProtKB:P08142|PomBase:SPBP35G2.07|UniProtKB:P9WG41|UniProtKB:P00893|AGI_LocusCode:AT3G48560|CGD:CAL0000198378 gcl GO:0050660 flavin adenine dinucleotide binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gcl/gcl-ai-review.yaml PTHR18968 PTN002317630 AN100 ok True PTN000438682 AN0 6 DUPLICATION True True 246 2 UniProtKB:P0AEP7|SGD:S000004714 gcvH1 GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvH1/gcvH1-ai-review.yaml PTHR11715 PTN002271035 AN476 no_same_term_ibd_on_path False gcvH1 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvH1/gcvH1-ai-review.yaml PTHR11715 PTN002271035 AN476 ok True PTN000196915 AN431 4 SPECIATION Eubacteria Eubacteria True False True 37 1 UniProtKB:P0A6T9 gcvH1 GO:0009249 protein lipoylation biological_process UNDECIDED genes/PSEPK/gcvH1/gcvH1-ai-review.yaml PTHR11715 PTN002271035 AN476 no_same_term_ibd_on_path False gcvH2 GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvH2/gcvH2-ai-review.yaml PTHR11715 PTN002271036 AN478 no_same_term_ibd_on_path False gcvH2 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvH2/gcvH2-ai-review.yaml PTHR11715 PTN002271036 AN478 ok True PTN000196915 AN431 4 SPECIATION Eubacteria Eubacteria True False True 37 1 UniProtKB:P0A6T9 gcvH2 GO:0009249 protein lipoylation biological_process UNDECIDED genes/PSEPK/gcvH2/gcvH2-ai-review.yaml PTHR11715 PTN002271036 AN478 no_same_term_ibd_on_path False gcvP1 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvP1/gcvP1-ai-review.yaml PTHR11773 PTN002272723 AN286 ok True PTN000206531 AN0 5 SPECIATION LUCA LUCA True True True 157 1 UniProtKB:P33195 gcvP1 GO:0005960 glycine cleavage complex cellular_component ACCEPT genes/PSEPK/gcvP1/gcvP1-ai-review.yaml PTHR11773 PTN002272723 AN286 no_same_term_ibd_on_path False gcvP1 GO:0016594 glycine binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gcvP1/gcvP1-ai-review.yaml PTHR11773 PTN002272723 AN286 no_same_term_ibd_on_path False gcvP1 GO:0030170 pyridoxal phosphate binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gcvP1/gcvP1-ai-review.yaml PTHR11773 PTN002272723 AN286 no_same_term_ibd_on_path False gcvP2 GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvP2/gcvP2-ai-review.yaml PTHR11773 PTN002272715 AN279 ok True PTN000206531 AN0 5 SPECIATION LUCA LUCA True True True 157 1 UniProtKB:P33195 gcvP2 GO:0005960 glycine cleavage complex cellular_component ACCEPT genes/PSEPK/gcvP2/gcvP2-ai-review.yaml PTHR11773 PTN002272715 AN279 no_same_term_ibd_on_path False gcvP2 GO:0016594 glycine binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gcvP2/gcvP2-ai-review.yaml PTHR11773 PTN002272715 AN279 no_same_term_ibd_on_path False gcvP2 GO:0030170 pyridoxal phosphate binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gcvP2/gcvP2-ai-review.yaml PTHR11773 PTN002272715 AN279 no_same_term_ibd_on_path False gcvT GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gcvT/gcvT-ai-review.yaml PTHR43757 PTN002464734 AN367 ok True PTN000354130 AN336 3 SPECIATION Eubacteria Eubacteria True False False 25 1 UniProtKB:P27248 gdhA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/gdhA/gdhA-ai-review.yaml PTHR43571 PTN002461478 AN179 ok True PTN000176341 AN0 4 SPECIATION LUCA LUCA True True False 102 3 UniProtKB:P18819|UniProtKB:Q8ILT0|UniProtKB:P00370 glgB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/glgB/glgB-ai-review.yaml PTHR43651 PTN002462574 AN494 ok True PTN000040010 AN20 4 SPECIATION LUCA LUCA True False False 257 4 MGI:MGI:1921435|AGI_LocusCode:AT3G20440|SGD:S000000737|UniProtKB:P07762 glgB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/glgB/glgB-ai-review.yaml PTHR43651 PTN002462574 AN494 ok True PTN000040086 AN463 3 SPECIATION Eubacteria Eubacteria True False False 24 1 UniProtKB:P07762 glgP GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/glgP/glgP-ai-review.yaml PTHR11468 PTN002263041 AN530 no_same_term_ibd_on_path False glgP GO:0005980 glycogen catabolic process biological_process ACCEPT genes/PSEPK/glgP/glgP-ai-review.yaml PTHR11468 PTN002263041 AN530 ok True PTN000157685 AN0 5 SPECIATION LUCA LUCA True True True 278 14 dictyBase:DDB_G0291123|RGD:3460|RGD:3461|RGD:620687|SGD:S000006364|MGI:MGI:97828|FB:FBgn0004507|MGI:MGI:97830|dictyBase:DDB_G0281383|UniProtKB:P0AC86|UniProtKB:P00490|UniProtKB:P11217|CGD:CAL0000189831|MGI:MGI:97829 glk GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/glk/glk-ai-review.yaml PTHR47690 PTN002412266 AN9 ok True PTN000775530 AN0 2 SPECIATION Proteobacteria Proteobacteria True True False 10 1 UniProtKB:P0A6V8 glnA GO:0016020 membrane cellular_component REMOVE genes/PSEPK/glnA/glnA-ai-review.yaml PTHR43407 PTN002459220 AN95 ok True PTN000464923 AN0 5 SPECIATION LUCA LUCA True True True 66 1 MGI:MGI:2672844 glnA GO:0019740 nitrogen utilization biological_process KEEP_AS_NON_CORE genes/PSEPK/glnA/glnA-ai-review.yaml PTHR43407 PTN002459220 AN95 ok True PTN000464923 AN0 5 SPECIATION LUCA LUCA True True True 66 3 UniProtKB:P0A9C5|UniProtKB:P9WN39|UniProtKB:P0A1P6 glnK GO:0005524 ATP binding molecular_function ACCEPT genes/PSEPK/glnK/glnK-ai-review.yaml PTHR30115 PTN002409593 AN166 ok True PTN004739388 AN0 7 DUPLICATION True True 104 3 UniProtKB:P0A9Z1|UniProtKB:P9WN31|AGI_LocusCode:AT4G01900 glnK GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/glnK/glnK-ai-review.yaml PTHR30115 PTN002409593 AN166 ok True PTN004739388 AN0 7 DUPLICATION True True 104 1 UniProtKB:P0A9Z1 glnS GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/glnS/glnS-ai-review.yaml PTHR43097 PTN002454589 AN459 ok True PTN000012556 AN0 4 SPECIATION LUCA LUCA True True False 249 3 UniProtKB:P00962|SGD:S000005694|UniProtKB:P47897 glpD GO:0046168 glycerol-3-phosphate catabolic process biological_process ACCEPT genes/PSEPK/glpD/glpD-ai-review.yaml PTHR11985 PTN002279478 AN259 ok True PTN008531994 AN249 4 DUPLICATION LUCA True False True 33 2 UniProtKB:P0A9C0|UniProtKB:P13035 glpF GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/glpF/glpF-ai-review.yaml PTHR43829 PTN002466301 AN383 ok True PTN000440994 AN0 3 SPECIATION LUCA LUCA True True False 224 17 WB:WBGene00000169|MGI:MGI:1314647|UniProtKB:Q92482|MGI:MGI:1333777|UniProtKB:O43315|UniProtKB:Q585Q8|UniProtKB:Q4Q6R2|UniProtKB:Q388I6|UniProtKB:O14520|RGD:68433|SGD:S000003966|UniProtKB:P0AER0|UniProtKB:Q388I5|RGD:2145|UniProtKB:Q96PS8|RGD:68428|MGI:MGI:1891066 glpF GO:0015793 glycerol transmembrane transport biological_process ACCEPT genes/PSEPK/glpF/glpF-ai-review.yaml PTHR43829 PTN002466301 AN383 ok True PTN000440994 AN0 3 SPECIATION LUCA LUCA True True False 224 17 UniProtKB:Q4Q6R2|UniProtKB:O43315|UniProtKB:Q585Q8|MGI:MGI:1333777|UniProtKB:Q92482|MGI:MGI:1314647|WB:WBGene00000169|WB:WBGene00000171|UniProtKB:O14520|UniProtKB:Q388I6|RGD:68428|UniProtKB:Q8II36|UniProtKB:Q96PS8|RGD:2145|UniProtKB:Q388I5|SGD:S000003966|UniProtKB:P0AER0 glpK GO:0006071 glycerol metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/glpK/glpK-ai-review.yaml PTHR10196 PTN002230053 AN820 no_same_term_ibd_on_path False gltB GO:0019676 ammonia assimilation cycle biological_process ACCEPT genes/PSEPK/gltB/gltB-ai-review.yaml PTHR11938 PTN002278350 AN323 ok True PTN000234342 AN1 5 SPECIATION LUCA LUCA True False True 178 5 SGD:S000002330|AGI_LocusCode:AT5G53460|UniProtKB:Q0JKD0|UniProtKB:P09831|PomBase:SPAPB1E7.07 gltX GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/gltX/gltX-ai-review.yaml PTHR43311 PTN002457690 AN270 ok True PTN000804412 AN203 5 DUPLICATION LUCA True False True 50 1 UniProtKB:P04805 glyQ GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/glyQ/glyQ-ai-review.yaml PTHR30075 PTN000763960 AN84 ok True PTN000763960 AN84 0 SPECIATION Eubacteria Eubacteria True False False 24 1 UniProtKB:P00961 glyS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/glyS/glyS-ai-review.yaml PTHR30075 PTN002409385 AN110 ok True PTN000763960 AN84 3 SPECIATION Eubacteria Eubacteria True False False 24 1 UniProtKB:P00961 gpmI GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/gpmI/gpmI-ai-review.yaml PTHR31637 PTN002420056 AN239 ok True PTN000781271 AN210 3 SPECIATION Eubacteria Eubacteria True False False 22 1 UniProtKB:P37689 gpmI GO:0005975 carbohydrate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/gpmI/gpmI-ai-review.yaml PTHR31637 PTN002420056 AN239 ok True PTN000781248 AN0 4 SPECIATION LUCA LUCA True True False 133 1 WB:WBGene00019001 gpsA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gpsA/gpsA-ai-review.yaml PTHR11728 PTN002271201 AN637 ok True PTN000198006 AN0 4 SPECIATION LUCA LUCA True True False 344 6 UniProtKB:P0A6S7|UniProtKB:Q4QHG4|FB:FBgn0001128|AGI_LocusCode:AT2G41540|MGI:MGI:95679|SGD:S000002180 gpsA GO:0046474 glycerophospholipid biosynthetic process biological_process ACCEPT genes/PSEPK/gpsA/gpsA-ai-review.yaml PTHR11728 PTN002271201 AN637 ok True PTN000198151 AN631 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 9 1 UniProtKB:P0A6S7 groES GO:0046872 metal ion binding molecular_function REMOVE genes/PSEPK/groES/groES-ai-review.yaml PTHR10772 PTN002243569 AN725 ok True PTN000080668 AN0 5 SPECIATION LUCA LUCA True True True 398 1 UniProtKB:P9WPE5 groES GO:0051087 protein-folding chaperone binding molecular_function ACCEPT genes/PSEPK/groES/groES-ai-review.yaml PTHR10772 PTN002243569 AN725 ok True PTN000080668 AN0 5 SPECIATION LUCA LUCA True True True 398 3 UniProtKB:P61604|UniProtKB:Q8IDZ8|SGD:S000005546 grpE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/grpE/grpE-ai-review.yaml PTHR21237 PTN002327260 AN596 ok True PTN008575294 AN555 3 SPECIATION Eubacteria Eubacteria True False False 33 1 UniProtKB:P09372 gshA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/gshA/gshA-ai-review.yaml PTHR38761 PTN002446150 AN6 ok True PTN002215154 AN0 2 SPECIATION Eubacteria Eubacteria True True False 8 1 UniProtKB:P0A6W9 gshA GO:0046872 metal ion binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/gshA/gshA-ai-review.yaml PTHR38761 PTN002446150 AN6 ok True PTN002215154 AN0 2 SPECIATION Eubacteria Eubacteria True True False 8 1 UniProtKB:P0A6W9 gshB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/gshB/gshB-ai-review.yaml PTHR21621 PTN002330136 AN138 ok True PTN000492628 AN0 5 SPECIATION LUCA LUCA True True True 105 3 MGI:MGI:1918325|MGI:MGI:3040686|UniProtKB:P04425 gshB GO:0016879 ligase activity, forming carbon-nitrogen bonds molecular_function KEEP_AS_NON_CORE genes/PSEPK/gshB/gshB-ai-review.yaml PTHR21621 PTN002330136 AN138 ok True PTN000492628 AN0 5 SPECIATION LUCA LUCA True True True 105 5 MGI:MGI:3040686|UniProtKB:P04425|UniProtKB:P0C0U4|UniProtKB:Q58407|MGI:MGI:1918325 gspE GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/gspE/gspE-ai-review.yaml PTHR30258 PTN002016251 AN66 ok True PTN001250205 AN0 7 SPECIATION LUCA LUCA True True True 90 2 UniProtKB:P0AFA5|UniProtKB:Q00512 gspE GO:0015627 type II protein secretion system complex cellular_component ACCEPT genes/PSEPK/gspE/gspE-ai-review.yaml PTHR30258 PTN002016251 AN66 ok True PTN002016240 AN63 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:Q00512 gspE GO:0015628 protein secretion by the type II secretion system biological_process ACCEPT genes/PSEPK/gspE/gspE-ai-review.yaml PTHR30258 PTN002016251 AN66 ok True PTN002016240 AN63 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:Q00512 gspE GO:0016887 ATP hydrolysis activity molecular_function ACCEPT genes/PSEPK/gspE/gspE-ai-review.yaml PTHR30258 PTN002016251 AN66 ok True PTN001250205 AN0 7 SPECIATION LUCA LUCA True True True 90 1 UniProtKB:P22608 guaD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/guaD/guaD-ai-review.yaml PTHR11271 PTN002259155 AN158 ok True PTN000138454 AN0 7 DUPLICATION True True 83 2 MGI:MGI:95678|RGD:621617 guaD GO:0019239 deaminase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/guaD/guaD-ai-review.yaml PTHR11271 PTN002259155 AN158 ok True PTN000138454 AN0 7 DUPLICATION True True 83 6 SGD:S000002397|UniProtKB:Q9Y2T3|FB:FBgn0261436|RGD:621617|MGI:MGI:95678|UniProtKB:P76641 guaD GO:0046098 guanine metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/guaD/guaD-ai-review.yaml PTHR11271 PTN002259155 AN158 no_same_term_ibd_on_path False gyrA GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex cellular_component ACCEPT genes/PSEPK/gyrA/gyrA-ai-review.yaml PTHR43493 PTN002460506 AN175 ok True PTN001607041 AN0 6 SPECIATION LUCA LUCA True True True 105 3 UniProtKB:O67108|UniProtKB:P0AFI2|UniProtKB:Q9HUK1 hemB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/hemB/hemB-ai-review.yaml PTHR11458 PTN001689347 AN265 ok True PTN000156046 AN0 5 SPECIATION LUCA LUCA True True True 149 2 UniProtKB:P0ACB2|MGI:MGI:96853 hemB GO:0006783 heme biosynthetic process biological_process ACCEPT genes/PSEPK/hemB/hemB-ai-review.yaml PTHR11458 PTN001689347 AN265 ok True PTN000156046 AN0 5 SPECIATION LUCA LUCA True True True 149 6 RGD:2083|UniProtKB:Q8IL68|MGI:MGI:96853|UniProtKB:P13716|SGD:S000003008|UniProtKB:P0ACB2 hemB GO:0008270 zinc ion binding molecular_function ACCEPT genes/PSEPK/hemB/hemB-ai-review.yaml PTHR11458 PTN001689347 AN265 no_same_term_ibd_on_path False hemBB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/hemBB/hemBB-ai-review.yaml PTHR11458 PTN000894573 AN253 ok True PTN000156046 AN0 3 SPECIATION LUCA LUCA True True False 149 2 UniProtKB:P0ACB2|MGI:MGI:96853 hemBB GO:0006783 heme biosynthetic process biological_process ACCEPT genes/PSEPK/hemBB/hemBB-ai-review.yaml PTHR11458 PTN000894573 AN253 ok True PTN000156046 AN0 3 SPECIATION LUCA LUCA True True False 149 6 RGD:2083|UniProtKB:Q8IL68|MGI:MGI:96853|UniProtKB:P13716|SGD:S000003008|UniProtKB:P0ACB2 hemBB GO:0008270 zinc ion binding molecular_function MODIFY genes/PSEPK/hemBB/hemBB-ai-review.yaml PTHR11458 PTN000894573 AN253 no_same_term_ibd_on_path False hemE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/hemE/hemE-ai-review.yaml PTHR21091 PTN002326258 AN357 ok True PTN000472929 AN222 4 SPECIATION Eubacteria Eubacteria True False False 79 4 SGD:S000002454|UniProtKB:P29680|UniProtKB:P06132|MGI:MGI:98916 hemE GO:0006783 heme biosynthetic process biological_process ACCEPT genes/PSEPK/hemE/hemE-ai-review.yaml PTHR21091 PTN002326258 AN357 ok True PTN000472929 AN222 4 SPECIATION Eubacteria Eubacteria True False False 79 4 UniProtKB:P29680|UniProtKB:P06132|MGI:MGI:98916|SGD:S000002454 hfq GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/hfq/hfq-ai-review.yaml PTHR34772 PTN002439139 AN23 ok True PTN002164223 AN0 3 SPECIATION Eubacteria Eubacteria True True False 20 1 UniProtKB:P0A6X3 hfq GO:0043487 regulation of RNA stability biological_process ACCEPT genes/PSEPK/hfq/hfq-ai-review.yaml PTHR34772 PTN002439139 AN23 ok True PTN002164223 AN0 3 SPECIATION Eubacteria Eubacteria True True False 20 1 UniProtKB:Q9HUM0 hfq GO:0045974 regulation of translation, ncRNA-mediated biological_process ACCEPT genes/PSEPK/hfq/hfq-ai-review.yaml PTHR34772 PTN002439139 AN23 ok True PTN002164223 AN0 3 SPECIATION Eubacteria Eubacteria True True False 20 2 UniProtKB:P0A6X3|UniProtKB:Q9HUM0 hisA GO:0000162 L-tryptophan biosynthetic process biological_process REMOVE genes/PSEPK/hisA/hisA-ai-review.yaml PTHR43090 PTN002454225 AN185 no_same_term_ibd_on_path False hisD GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/hisD/hisD-ai-review.yaml PTHR21256 PTN002327387 AN186 no_same_term_ibd_on_path False hisD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/hisD/hisD-ai-review.yaml PTHR21256 PTN002327387 AN186 ok True PTN000479119 AN149 3 SPECIATION Eubacteria Eubacteria True False False 30 1 UniProtKB:P06988 hldE GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/hldE/hldE-ai-review.yaml PTHR46969 PTN005327360 AN25 ok True PTN000062036 AN0 3 SPECIATION Eubacteria Eubacteria True True False 23 1 UniProtKB:P76658 hmgA GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/hmgA/hmgA-ai-review.yaml PTHR11056 PTN002252947 AN219 no_same_term_ibd_on_path False hmgB GO:0006572 L-tyrosine catabolic process biological_process ACCEPT genes/PSEPK/hmgB/hmgB-ai-review.yaml PTHR43069 PTN002453800 AN221 ok True PTN002453799 AN0 2 SPECIATION Eubacteria Eubacteria True True False 114 2 MGI:MGI:95482|AGI_LocusCode:AT1G12050 hmgB GO:1902000 homogentisate catabolic process biological_process ACCEPT genes/PSEPK/hmgB/hmgB-ai-review.yaml PTHR43069 PTN002453800 AN221 ok True PTN002453799 AN0 2 SPECIATION Eubacteria Eubacteria True True False 114 1 AGI_LocusCode:AT1G12050 hmgC GO:0004364 glutathione transferase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/hmgC/hmgC-ai-review.yaml PTHR42673 PTN002448156 AN17 ok True PTN001344486 AN0 6 SPECIATION LUCA LUCA True True True 215 5 ZFIN:ZDB-GENE-040718-184|UniProtKB:O43708|FB:FBgn0037697|UniProtKB:P77544|FB:FBgn0037696 hmgC GO:0006559 L-phenylalanine catabolic process biological_process ACCEPT genes/PSEPK/hmgC/hmgC-ai-review.yaml PTHR42673 PTN002448156 AN17 ok True PTN001344486 AN0 6 SPECIATION LUCA LUCA True True True 215 1 UniProtKB:O43123 hmgC GO:0006749 glutathione metabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/hmgC/hmgC-ai-review.yaml PTHR42673 PTN002448156 AN17 ok True PTN001344486 AN0 6 SPECIATION LUCA LUCA True True True 215 3 FB:FBgn0037697|FB:FBgn0037696|UniProtKB:O43708 hmp GO:0046210 nitric oxide catabolic process biological_process ACCEPT genes/PSEPK/hmp/hmp-ai-review.yaml PTHR43396 PTN002459120 AN68 no_same_term_ibd_on_path False hmp GO:0071500 cellular response to nitrosative stress biological_process ACCEPT genes/PSEPK/hmp/hmp-ai-review.yaml PTHR43396 PTN002459120 AN68 ok True PTN001116481 AN0 3 SPECIATION LUCA LUCA True True False 40 5 UniProtKB:Q5AX11|PomBase:SPAC869.02c|dictyBase:DDB_G0292380|CGD:CAL0000179202|dictyBase:DDB_G0292378 hpd GO:0006572 L-tyrosine catabolic process biological_process ACCEPT genes/PSEPK/hpd/hpd-ai-review.yaml PTHR11959 PTN000238655 AN327 ok True PTN000238649 AN0 1 SPECIATION Eubacteria Eubacteria True True False 174 4 RGD:61974|FB:FBgn0036992|UniProtKB:Q4WHU1|UniProtKB:P32754 hscB GO:1990230 iron-sulfur cluster transfer complex cellular_component ACCEPT genes/PSEPK/hscB/hscB-ai-review.yaml PTHR14021 PTN002304125 AN7 ok True PTN004450613 AN0 3 HORIZONTAL_TRANSFER True False 113 1 UniProtKB:P0A6L9 hutF GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/hutF/hutF-ai-review.yaml PTHR11271 PTN002462020 AN13 ok True PTN000138454 AN0 5 DUPLICATION True True 83 2 MGI:MGI:95678|RGD:621617 hutF GO:0019239 deaminase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/hutF/hutF-ai-review.yaml PTHR11271 PTN002462020 AN13 ok True PTN000138454 AN0 5 DUPLICATION True True 83 6 SGD:S000002397|UniProtKB:Q9Y2T3|FB:FBgn0261436|RGD:621617|MGI:MGI:95678|UniProtKB:P76641 hyi GO:0046487 glyoxylate metabolic process biological_process ACCEPT genes/PSEPK/hyi/hyi-ai-review.yaml PTHR43489 PTN002460276 AN90 ok True PTN001740130 AN1 7 SPECIATION Eubacteria Eubacteria True False True 48 1 UniProtKB:P30147 ileS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ileS/ileS-ai-review.yaml PTHR42765 PTN002449567 AN266 ok True PTN000235772 AN0 4 SPECIATION LUCA LUCA True True False 150 1 UniProtKB:P00956 ilvA-I GO:0003941 L-serine ammonia-lyase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/ilvA-I/ilvA-I-ai-review.yaml PTHR48078 PTN002463974 AN233 no_same_term_ibd_on_path False ilvA-I GO:0006565 L-serine catabolic process biological_process UNDECIDED genes/PSEPK/ilvA-I/ilvA-I-ai-review.yaml PTHR48078 PTN002463974 AN233 no_same_term_ibd_on_path False ilvA-I GO:0006567 L-threonine catabolic process biological_process ACCEPT genes/PSEPK/ilvA-I/ilvA-I-ai-review.yaml PTHR48078 PTN002463974 AN233 no_same_term_ibd_on_path False ilvA-II GO:0003941 L-serine ammonia-lyase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/ilvA-II/ilvA-II-ai-review.yaml PTHR48078 PTN002463976 AN234 no_same_term_ibd_on_path False ilvA-II GO:0006565 L-serine catabolic process biological_process UNDECIDED genes/PSEPK/ilvA-II/ilvA-II-ai-review.yaml PTHR48078 PTN002463976 AN234 no_same_term_ibd_on_path False ilvA-II GO:0006567 L-threonine catabolic process biological_process ACCEPT genes/PSEPK/ilvA-II/ilvA-II-ai-review.yaml PTHR48078 PTN002463976 AN234 no_same_term_ibd_on_path False ilvC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ilvC/ilvC-ai-review.yaml PTHR21371 PTN002328185 AN252 ok True PTN000483145 AN211 4 SPECIATION Eubacteria Eubacteria True False False 32 1 UniProtKB:P05793 ilvD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ilvD/ilvD-ai-review.yaml PTHR43661 PTN002462739 AN53 ok True PTN000470254 AN0 5 SPECIATION LUCA LUCA True True True 40 1 UniProtKB:P05791 ilvH GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ilvH/ilvH-ai-review.yaml PTHR30239 PTN002410438 AN239 ok True PTN000767018 AN0 4 SPECIATION LUCA LUCA True True False 137 1 UniProtKB:P00894 ilvI GO:0005948 acetolactate synthase complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/ilvI/ilvI-ai-review.yaml PTHR18968 PTN002317652 AN431 ok True PTN000438758 AN17 8 SPECIATION LUCA LUCA True False True 237 3 UniProtKB:P08142|SGD:S000004714|UniProtKB:P00893 infA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/infA/infA-ai-review.yaml PTHR33370 PTN002433371 AN157 ok True PTN002120795 AN116 3 SPECIATION Eubacteria Eubacteria True False False 33 1 UniProtKB:P69222 infB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/infB/infB-ai-review.yaml PTHR43381 PTN002458826 AN697 ok True PTN000562019 AN656 3 SPECIATION Eubacteria Eubacteria True False False 33 1 UniProtKB:P0A705 infC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/infC/infC-ai-review.yaml PTHR10938 PTN002249955 AN339 ok True PTN000101520 AN294 4 SPECIATION Eubacteria Eubacteria True False False 35 1 UniProtKB:P0A707 infC GO:0016020 membrane cellular_component REMOVE genes/PSEPK/infC/infC-ai-review.yaml PTHR10938 PTN002249955 AN339 no_same_term_ibd_on_path False iscA GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/iscA/iscA-ai-review.yaml PTHR10072 PTN002225865 AN301 ok True PTN001601055 AN0 5 SPECIATION LUCA LUCA True True False 166 5 UniProtKB:Q57X28|PomBase:SPCC645.03c|UniProtKB:Q9BUE6|UniProtKB:P0AAC8|SGD:S000003950 iscA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/iscA/iscA-ai-review.yaml PTHR10072 PTN002225865 AN301 ok True PTN000008061 AN290 2 SPECIATION Proteobacteria Proteobacteria True False False 15 1 UniProtKB:P0AAC8 ivd GO:0006552 L-leucine catabolic process biological_process ACCEPT genes/PSEPK/ivd/ivd-ai-review.yaml PTHR43884 PTN002467027 AN8 ok True PTN005188837 AN3 2 HORIZONTAL_TRANSFER Archaea-Eukaryota False False False 127 4 UniProtKB:P26440|AGI_LocusCode:AT3G45300|RGD:2936|MGI:MGI:1929242 katA GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/katA/katA-ai-review.yaml PTHR11465 PTN008518476 AN193 ok True PTN000157250 AN0 3 DUPLICATION True True 283 14 UniProtKB:P00432|AGI_LocusCode:AT4G35090|dictyBase:DDB_G0274595|WB:WBGene00000831|UniProtKB:P04040|SGD:S000002664|UniProtKB:Q0E4K1|UniProtKB:P18123|AGI_LocusCode:AT1G20620|RGD:2279|UniProtKB:Q10S82|FB:FBgn0000261|UniProtKB:Q0D9C4|MGI:MGI:88271 katA GO:0042542 response to hydrogen peroxide biological_process KEEP_AS_NON_CORE genes/PSEPK/katA/katA-ai-review.yaml PTHR11465 PTN008518476 AN193 ok True PTN000157250 AN0 3 DUPLICATION True True 283 8 UniProtKB:P04040|UniProtKB:Q0E4K1|UniProtKB:Q0D9C4|AGI_LocusCode:AT1G20630|PomBase:SPCC757.07c|FB:FBgn0000261|UniProtKB:Q10S82|CGD:CAL0000188148 katG GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/katG/katG-ai-review.yaml PTHR30555 PTN004744464 AN19 ok True PTN000777458 AN0 4 SPECIATION LUCA LUCA True True False 25 2 UniProtKB:P9WIE5|UniProtKB:P13029 katG GO:0042744 hydrogen peroxide catabolic process biological_process ACCEPT genes/PSEPK/katG/katG-ai-review.yaml PTHR30555 PTN004744464 AN19 ok True PTN000777458 AN0 4 SPECIATION LUCA LUCA True True False 25 2 UniProtKB:P13029|UniProtKB:P9WIE5 katG GO:0070301 cellular response to hydrogen peroxide biological_process KEEP_AS_NON_CORE genes/PSEPK/katG/katG-ai-review.yaml PTHR30555 PTN004744464 AN19 ok True PTN000777458 AN0 4 SPECIATION LUCA LUCA True True False 25 1 UniProtKB:P13029 kdpA GO:0071805 potassium ion transmembrane transport biological_process ACCEPT genes/PSEPK/kdpA/kdpA-ai-review.yaml PTHR30607 PTN002412985 AN22 ok True PTN001255318 AN0 4 SPECIATION LUCA LUCA True True False 18 1 UniProtKB:P03959 kdpC GO:0071805 potassium ion transmembrane transport biological_process ACCEPT genes/PSEPK/kdpC/kdpC-ai-review.yaml PTHR30042 PTN002409044 AN24 ok True PTN001247299 AN0 5 SPECIATION LUCA LUCA True True False 19 1 UniProtKB:P03961 kdpD GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/kdpD/kdpD-ai-review.yaml PTHR45569 PTN002401364 AN22 ok True PTN001976096 AN0 3 SPECIATION Eubacteria Eubacteria True True False 18 1 UniProtKB:P21865 kdpE GO:0000156 phosphorelay response regulator activity molecular_function ACCEPT genes/PSEPK/kdpE/kdpE-ai-review.yaml PTHR48111 PTN002403495 AN634 ok True PTN000724188 AN0 5 SPECIATION LUCA LUCA True True True 475 10 UniProtKB:P0AE88|UniProtKB:P0AA16|UniProtKB:P30843|UniProtKB:Q9I2U3|UniProtKB:P0A9Q1|UniProtKB:Q8DPL7|UniProtKB:Q8DN02|UniProtKB:O07776|UniProtKB:P36556|UniProtKB:P38684 kdpE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/kdpE/kdpE-ai-review.yaml PTHR48111 PTN002403495 AN634 ok True PTN000724188 AN0 5 SPECIATION LUCA LUCA True True True 475 4 UniProtKB:P69228|UniProtKB:P23836|UniProtKB:P0A9Q1|UniProtKB:P0AE88 kdpE GO:0032993 protein-DNA complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/kdpE/kdpE-ai-review.yaml PTHR48111 PTN002403495 AN634 ok True PTN000724188 AN0 5 SPECIATION LUCA LUCA True True True 475 6 UniProtKB:Q8EE50|UniProtKB:P26275|UniProtKB:P0A9Q1|UniProtKB:P23836|UniProtKB:Q8EHJ3|UniProtKB:O24973 kdsB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/kdsB/kdsB-ai-review.yaml PTHR42866 PTN002450837 AN172 ok True PTN000486365 AN159 2 SPECIATION Proteobacteria Proteobacteria True False False 14 1 UniProtKB:P04951 kdsC GO:0008781 N-acylneuraminate cytidylyltransferase activity molecular_function REMOVE genes/PSEPK/kdsC/kdsC-ai-review.yaml PTHR21485 PTN000486303 AN0 ok True PTN000486303 AN0 0 SPECIATION LUCA LUCA True True False 46 6 ZFIN:ZDB-GENE-120427-1|FB:FBgn0052220|UniProtKB:Q3SZM5|UniProtKB:Q8NFW8|MGI:MGI:1337124|ZFIN:ZDB-GENE-050420-277 kguT GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/kguT/kguT-ai-review.yaml PTHR43791 PTN002465417 AN781 ok True PTN002465406 AN773 2 DUPLICATION Proteobacteria True False True 13 2 UniProtKB:P76470|UniProtKB:P32135 leuB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/leuB/leuB-ai-review.yaml PTHR42979 PTN002452704 AN192 ok True PTN000216982 AN0 4 SPECIATION LUCA LUCA True True False 111 3 UniProtKB:P30125|PomBase:SPBC1A4.02c|SGD:S000000523 leuS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/leuS/leuS-ai-review.yaml PTHR43740 PTN002464594 AN231 ok True PTN000236475 AN100 3 SPECIATION Eubacteria Eubacteria True False False 79 1 UniProtKB:P07813 ligA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/ligA/ligA-ai-review.yaml PTHR23389 PTN002361138 AN541 ok True PTN000121726 AN496 3 SPECIATION Eubacteria Eubacteria True False False 35 1 UniProtKB:P15042 liuC GO:0008300 isoprenoid catabolic process biological_process REMOVE genes/PSEPK/liuC/liuC-ai-review.yaml PTHR42964 PTN002452383 AN22 no_same_term_ibd_on_path False lolA GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/PSEPK/lolA/lolA-ai-review.yaml PTHR35869 PTN002441842 AN21 ok True PTN002185387 AN15 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 9 1 UniProtKB:P61316 lolC GO:0044874 lipoprotein localization to outer membrane biological_process ACCEPT genes/PSEPK/lolC/lolC-ai-review.yaml PTHR30489 PTN002412113 AN62 ok True PTN002524722 AN0 6 SPECIATION LUCA LUCA True True True 46 4 UniProtKB:P0ADC3|UniProtKB:Q9HZL6|UniProtKB:Q9HZL8|UniProtKB:P75958 lolC GO:0098797 plasma membrane protein complex cellular_component ACCEPT genes/PSEPK/lolC/lolC-ai-review.yaml PTHR30489 PTN002412113 AN62 ok True PTN002524722 AN0 6 SPECIATION LUCA LUCA True True True 46 2 UniProtKB:P75958|UniProtKB:P0ADC3 lolD GO:0022857 transmembrane transporter activity molecular_function MODIFY genes/PSEPK/lolD/lolD-ai-review.yaml PTHR24220 PTN002383677 AN326 ok True PTN000655654 AN0 7 DUPLICATION True True 294 1 UniProtKB:P9WQL7 lolD GO:0055085 transmembrane transport biological_process REMOVE genes/PSEPK/lolD/lolD-ai-review.yaml PTHR24220 PTN002383677 AN326 ok True PTN000655654 AN0 7 DUPLICATION True True 294 3 UniProtKB:P33916|UniProtKB:P9WQL7|UniProtKB:P33593 lolE GO:0044874 lipoprotein localization to outer membrane biological_process ACCEPT genes/PSEPK/lolE/lolE-ai-review.yaml PTHR30489 PTN002412111 AN59 ok True PTN002524722 AN0 5 SPECIATION LUCA LUCA True True True 46 4 UniProtKB:P0ADC3|UniProtKB:Q9HZL6|UniProtKB:Q9HZL8|UniProtKB:P75958 lolE GO:0098797 plasma membrane protein complex cellular_component ACCEPT genes/PSEPK/lolE/lolE-ai-review.yaml PTHR30489 PTN002412111 AN59 ok True PTN002524722 AN0 5 SPECIATION LUCA LUCA True True True 46 2 UniProtKB:P75958|UniProtKB:P0ADC3 lpd GO:0006103 2-oxoglutarate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/lpd/lpd-ai-review.yaml PTHR22912 PTN002340778 AN563 ok True PTN000530299 AN0 4 SPECIATION LUCA LUCA True True True 304 4 UniProtKB:P0A9P0|SGD:S000001876|UniProtKB:P09622|RGD:735073 lpdG GO:0006103 2-oxoglutarate metabolic process biological_process ACCEPT genes/PSEPK/lpdG/lpdG-ai-review.yaml PTHR22912 PTN002340706 AN23 ok True PTN000530299 AN0 5 SPECIATION LUCA LUCA True True True 304 4 UniProtKB:P0A9P0|SGD:S000001876|UniProtKB:P09622|RGD:735073 lpdV GO:0006103 2-oxoglutarate metabolic process biological_process REMOVE genes/PSEPK/lpdV/lpdV-ai-review.yaml PTHR22912 PTN002340777 AN45 ok True PTN000530299 AN0 6 SPECIATION LUCA LUCA True True True 304 4 UniProtKB:P0A9P0|SGD:S000001876|UniProtKB:P09622|RGD:735073 lptA GO:0009279 cell outer membrane cellular_component MARK_AS_OVER_ANNOTATED genes/PSEPK/lptA/lptA-ai-review.yaml PTHR36504 PTN002863032 AN15 ok True PTN002194456 AN0 3 SPECIATION Eubacteria Eubacteria True True False 16 1 UniProtKB:P0ADV1 lptA GO:0017089 glycolipid transfer activity molecular_function MODIFY genes/PSEPK/lptA/lptA-ai-review.yaml PTHR36504 PTN002863032 AN15 ok True PTN002194456 AN0 3 SPECIATION Eubacteria Eubacteria True True False 16 1 UniProtKB:P0ADV1 lptA GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/PSEPK/lptA/lptA-ai-review.yaml PTHR36504 PTN002863032 AN15 ok True PTN002194456 AN0 3 SPECIATION Eubacteria Eubacteria True True False 16 1 UniProtKB:P0ADV1 lptC GO:0017089 glycolipid transfer activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/lptC/lptC-ai-review.yaml PTHR37481 PTN002444743 AN14 ok True PTN002444741 AN0 3 SPECIATION Eubacteria Eubacteria True True False 14 1 UniProtKB:P0ADV9 lptC GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/PSEPK/lptC/lptC-ai-review.yaml PTHR37481 PTN002444743 AN14 ok True PTN002444741 AN0 3 SPECIATION Eubacteria Eubacteria True True False 14 1 UniProtKB:P0ADV9 lptD GO:1990351 transporter complex cellular_component ACCEPT genes/PSEPK/lptD/lptD-ai-review.yaml PTHR30189 PTN002410171 AN26 ok True PTN001249597 AN0 4 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P31554 lptE GO:0001530 lipopolysaccharide binding molecular_function ACCEPT genes/PSEPK/lptE/lptE-ai-review.yaml PTHR38098 PTN002445559 AN10 ok True PTN002211326 AN2 2 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 10 1 UniProtKB:P0ADC1 lptE GO:0015920 lipopolysaccharide transport biological_process ACCEPT genes/PSEPK/lptE/lptE-ai-review.yaml PTHR38098 PTN002445559 AN10 ok True PTN002211326 AN2 2 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 10 1 UniProtKB:P0ADC1 lptE GO:1990351 transporter complex cellular_component ACCEPT genes/PSEPK/lptE/lptE-ai-review.yaml PTHR38098 PTN002445559 AN10 ok True PTN002866256 AN0 3 SPECIATION Proteobacteria Proteobacteria True True False 11 1 UniProtKB:P0ADC1 lysS GO:0000049 tRNA binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/lysS/lysS-ai-review.yaml PTHR42918 PTN002451865 AN487 ok True PTN000502669 AN0 5 SPECIATION LUCA LUCA True True True 273 1 RGD:1359653 mazG GO:0006203 dGTP catabolic process biological_process ACCEPT genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mazG GO:0046047 TTP catabolic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mazG GO:0046052 UTP catabolic process biological_process ACCEPT genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mazG GO:0046061 dATP catabolic process biological_process ACCEPT genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mazG GO:0046076 dTTP catabolic process biological_process ACCEPT genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mazG GO:0046081 dUTP catabolic process biological_process ACCEPT genes/PSEPK/mazG/mazG-ai-review.yaml PTHR30522 PTN002412313 AN30 ok True PTN000775634 AN0 3 SPECIATION Eubacteria Eubacteria True True False 25 1 UniProtKB:P96379 mccB GO:0006552 L-leucine catabolic process biological_process ACCEPT genes/PSEPK/mccB/mccB-ai-review.yaml PTHR22855 PTN002338188 AN265 ok True PTN000523406 AN12 4 SPECIATION LUCA LUCA True False False 131 4 MGI:MGI:1925288|UniProtKB:Q9HCC0|AGI_LocusCode:AT4G34030|UniProtKB:C8VAZ1 mccB GO:1905202 methylcrotonoyl-CoA carboxylase complex cellular_component ACCEPT genes/PSEPK/mccB/mccB-ai-review.yaml PTHR22855 PTN002338188 AN265 ok True PTN000523406 AN12 4 SPECIATION LUCA LUCA True False False 131 2 UniProtKB:Q9I297|UniProtKB:Q9HCC0 mdh GO:0004459 L-lactate dehydrogenase (NAD+) activity molecular_function REMOVE genes/PSEPK/mdh/mdh-ai-review.yaml PTHR43128 PTN002454946 AN9 no_same_term_ibd_on_path False mdh GO:0006089 lactate metabolic process biological_process REMOVE genes/PSEPK/mdh/mdh-ai-review.yaml PTHR43128 PTN002454946 AN9 no_same_term_ibd_on_path False metB GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/metB/metB-ai-review.yaml PTHR11808 PTN008330292 AN533 ok True PTN000211590 AN0 2 DUPLICATION True True 295 6 MGI:MGI:1339968|SGD:S000003152|SGD:S000001154|AGI_LocusCode:AT1G64660|UniProtKB:Q38DH3|AGI_LocusCode:AT3G57050 metB GO:0016846 carbon-sulfur lyase activity molecular_function MODIFY genes/PSEPK/metB/metB-ai-review.yaml PTHR11808 PTN008330292 AN533 ok True PTN000211590 AN0 2 DUPLICATION True True 295 10 AGI_LocusCode:AT1G64660|UniProtKB:C8VM61|UniProtKB:O05394|UniProtKB:Q5AXC9|UniProtKB:P32929|UniProtKB:P9WGB7|SGD:S000003152|MGI:MGI:1339968|AGI_LocusCode:AT3G57050|SGD:S000000010 metF GO:0071949 FAD binding molecular_function ACCEPT genes/PSEPK/metF/metF-ai-review.yaml PTHR45754 PTN002326331 AN316 ok True PTN000472667 AN0 4 SPECIATION LUCA LUCA True True False 175 1 UniProtKB:P0AEZ1 metG GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/metG/metG-ai-review.yaml PTHR45765 PTN002278830 AN306 ok True PTN001734661 AN0 4 SPECIATION LUCA LUCA True True False 167 1 UniProtKB:P56192 metH GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/metH/metH-ai-review.yaml PTHR45833 PTN002326308 AN117 ok True PTN002501322 AN0 5 DUPLICATION True True 73 1 UniProtKB:P13009 metH GO:0046653 tetrahydrofolate metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/metH/metH-ai-review.yaml PTHR45833 PTN002326308 AN117 ok True PTN008699037 AN1 4 SPECIATION Eubacteria Eubacteria True False False 69 2 RGD:621283|UniProtKB:P13009 metH GO:0050667 homocysteine metabolic process biological_process MODIFY genes/PSEPK/metH/metH-ai-review.yaml PTHR45833 PTN002326308 AN117 no_same_term_ibd_on_path False metXS GO:0009092 L-homoserine metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/metXS/metXS-ai-review.yaml PTHR32268 PTN002426741 AN118 no_same_term_ibd_on_path False metZ GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/metZ/metZ-ai-review.yaml PTHR11808 PTN002273776 AN553 ok True PTN000211590 AN0 6 DUPLICATION True True 295 6 MGI:MGI:1339968|SGD:S000003152|SGD:S000001154|AGI_LocusCode:AT1G64660|UniProtKB:Q38DH3|AGI_LocusCode:AT3G57050 metZ GO:0016846 carbon-sulfur lyase activity molecular_function ACCEPT genes/PSEPK/metZ/metZ-ai-review.yaml PTHR11808 PTN002273776 AN553 ok True PTN000211590 AN0 6 DUPLICATION True True 295 10 AGI_LocusCode:AT1G64660|UniProtKB:C8VM61|UniProtKB:O05394|UniProtKB:Q5AXC9|UniProtKB:P32929|UniProtKB:P9WGB7|SGD:S000003152|MGI:MGI:1339968|AGI_LocusCode:AT3G57050|SGD:S000000010 mexB GO:0042910 xenobiotic transmembrane transporter activity molecular_function ACCEPT genes/PSEPK/mexB/mexB-ai-review.yaml PTHR32063 PTN000786627 AN13 ok True PTN004918764 AN0 4 HORIZONTAL_TRANSFER True True 183 2 UniProtKB:P31224|UniProtKB:P37637 mfd GO:0003678 DNA helicase activity molecular_function MODIFY genes/PSEPK/mfd/mfd-ai-review.yaml PTHR47964 PTN008723670 AN4 ok True PTN002773745 AN0 3 SPECIATION LUCA LUCA True True False 79 4 UniProtKB:Q9HTL3|UniProtKB:P24230|UniProtKB:P9WMQ7|UniProtKB:O34942 mlaD GO:0005543 phospholipid binding molecular_function ACCEPT genes/PSEPK/mlaD/mlaD-ai-review.yaml PTHR33371 PTN002433415 AN67 no_same_term_ibd_on_path False mlaE GO:0015914 phospholipid transport biological_process ACCEPT genes/PSEPK/mlaE/mlaE-ai-review.yaml PTHR30188 PTN002410168 AN138 ok True PTN000766204 AN0 4 DUPLICATION True True 89 1 UniProtKB:P64606 mnmA GO:0002143 tRNA wobble position uridine thiolation biological_process ACCEPT genes/PSEPK/mnmA/mnmA-ai-review.yaml PTHR11933 PTN002277965 AN174 ok True PTN000232426 AN12 4 SPECIATION LUCA LUCA True False False 94 2 UniProtKB:P25745|SGD:S000002191 moaA GO:0061799 cyclic pyranopterin monophosphate synthase activity molecular_function REMOVE genes/PSEPK/moaA/moaA-ai-review.yaml PTHR22960 PTN002344120 AN269 ok True PTN000539172 AN6 6 SPECIATION LUCA LUCA True False True 141 2 MGI:MGI:1928904|UniProtKB:Q9NZB8 moaB-I GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/moaB-I/moaB-I-ai-review.yaml PTHR43232 PTN002456466 AN28 ok True PTN002456460 AN0 5 SPECIATION LUCA LUCA True True True 21 1 UniProtKB:P0AEZ9 moaB-II GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/moaB-II/moaB-II-ai-review.yaml PTHR43232 PTN002456466 AN28 ok True PTN002456460 AN0 5 SPECIATION LUCA LUCA True True True 21 1 UniProtKB:P0AEZ9 moaD GO:1990133 molybdopterin adenylyltransferase complex cellular_component ACCEPT genes/PSEPK/moaD/moaD-ai-review.yaml PTHR33359 PTN002433321 AN170 ok True PTN008655638 AN0 5 SPECIATION LUCA LUCA True True False 94 1 UniProtKB:P30748 mobA GO:1902758 bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process biological_process ACCEPT genes/PSEPK/mobA/mobA-ai-review.yaml PTHR19136 PTN002318022 AN75 ok True PTN001452269 AN65 2 SPECIATION Proteobacteria Proteobacteria True False False 12 1 UniProtKB:P32173 moeA GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/moeA/moeA-ai-review.yaml PTHR10192 PTN002229918 AN266 ok True PTN000022760 AN0 7 SPECIATION LUCA LUCA True True True 147 5 WB:WBGene00003031|UniProtKB:Q9NQX3|UniProtKB:P12281|RGD:69194|MGI:MGI:109602 moeA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/moeA/moeA-ai-review.yaml PTHR10192 PTN002229918 AN266 ok True PTN000022759 AN26 6 DUPLICATION LUCA True False True 131 4 UniProtKB:Q9NQX3|UniProtKB:P12281|MGI:MGI:109602|RGD:69194 moeB GO:0004792 thiosulfate-cyanide sulfurtransferase activity molecular_function REMOVE genes/PSEPK/moeB/moeB-ai-review.yaml PTHR10953 PTN002250299 AN2057 ok True PTN000102040 AN0 6 SPECIATION LUCA LUCA True True True 1090 1 SGD:S000001153 moeB GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/moeB/moeB-ai-review.yaml PTHR10953 PTN002250299 AN2057 ok True PTN000102040 AN0 6 SPECIATION LUCA LUCA True True True 1090 27 AGI_LocusCode:AT2G32410|PomBase:SPBC1604.21c|UniProtKB:Q8IDZ6|UniProtKB:O95352|UniProtKB:P41226|UniProtKB:P30138|SGD:S000006384|MGI:MGI:1921494|UniProtKB:Q8I5F9|UniProtKB:Q8ID54|UniProtKB:Q38F81|dictyBase:DDB_G0271096|WB:WBGene00004341|UniProtKB:P12282|FB:FBgn0029113|UniProtKB:Q386S6|SGD:S000001693|UniProtKB:A0AVT1|UniProtKB:Q586W2|UniProtKB:Q57XC5|FB:FBgn0032054|UniProtKB:Q9UBE0|UniProtKB:Q9GZZ9|UniProtKB:O95396|SGD:S000001214|UniProtKB:P22314|UniProtKB:Q389M1 moeB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/moeB/moeB-ai-review.yaml PTHR10953 PTN002250299 AN2057 ok True PTN000102608 AN2009 4 SPECIATION Eubacteria Eubacteria True False True 39 2 UniProtKB:P12282|UniProtKB:P30138 moeB GO:0008146 sulfotransferase activity molecular_function REMOVE genes/PSEPK/moeB/moeB-ai-review.yaml PTHR10953 PTN002250299 AN2057 ok True PTN000102608 AN2009 4 SPECIATION Eubacteria Eubacteria True False True 39 1 UniProtKB:P9WMN7 moeB GO:0016779 nucleotidyltransferase activity molecular_function ACCEPT genes/PSEPK/moeB/moeB-ai-review.yaml PTHR10953 PTN002250299 AN2057 ok True PTN000102040 AN0 6 SPECIATION LUCA LUCA True True True 1090 4 UniProtKB:O95396|SGD:S000001153|UniProtKB:P12282|UniProtKB:P30138 mqo1 GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity molecular_function REMOVE genes/PSEPK/mqo1/mqo1-ai-review.yaml PTHR43104 PTN001015070 AN205 ok True PTN002454638 AN0 6 SPECIATION LUCA LUCA True True True 126 5 MGI:MGI:2384968|UniProtKB:P37339|UniProtKB:Q9LES4|FB:FBgn0032729|UniProtKB:Q9H9P8 mqo2 GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity molecular_function REMOVE genes/PSEPK/mqo2/mqo2-ai-review.yaml PTHR43104 PTN001015070 AN205 ok True PTN002454638 AN0 6 SPECIATION LUCA LUCA True True True 126 5 MGI:MGI:2384968|UniProtKB:P37339|UniProtKB:Q9LES4|FB:FBgn0032729|UniProtKB:Q9H9P8 mqo3 GO:0047545 (S)-2-hydroxyglutarate dehydrogenase activity molecular_function REMOVE genes/PSEPK/mqo3/mqo3-ai-review.yaml PTHR43104 PTN001015070 AN205 ok True PTN002454638 AN0 6 SPECIATION LUCA LUCA True True True 126 5 MGI:MGI:2384968|UniProtKB:P37339|UniProtKB:Q9LES4|FB:FBgn0032729|UniProtKB:Q9H9P8 mraY GO:0044038 cell wall macromolecule biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/mraY/mraY-ai-review.yaml PTHR22926 PTN002341405 AN194 ok True PTN000531998 AN0 5 SPECIATION LUCA LUCA True True True 121 2 UniProtKB:P0AC78|UniProtKB:Q9X1N5 mraY GO:0071555 cell wall organization biological_process KEEP_AS_NON_CORE genes/PSEPK/mraY/mraY-ai-review.yaml PTHR22926 PTN002341405 AN194 ok True PTN000531998 AN0 5 SPECIATION LUCA LUCA True True True 121 2 UniProtKB:Q9X1N5|UniProtKB:P0AC78 mrcA GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/PSEPK/mrcA/mrcA-ai-review.yaml PTHR32282 PTN002426802 AN90 ok True PTN001283969 AN10 4 DUPLICATION LUCA True False True 77 2 UniProtKB:P02919|UniProtKB:P71707 mscL GO:0006811 monoatomic ion transport biological_process KEEP_AS_NON_CORE genes/PSEPK/mscL/mscL-ai-review.yaml PTHR30266 PTN002410587 AN49 no_same_term_ibd_on_path False mupP GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/mupP/mupP-ai-review.yaml PTHR43434 PTN002459629 AN162 ok True PTN001291474 AN57 5 DUPLICATION LUCA True False True 80 1 UniProtKB:P32662 mupP GO:0006281 DNA repair biological_process REMOVE genes/PSEPK/mupP/mupP-ai-review.yaml PTHR43434 PTN002459629 AN162 ok True PTN001052204 AN0 6 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 mupP GO:0008967 phosphoglycolate phosphatase activity molecular_function REMOVE genes/PSEPK/mupP/mupP-ai-review.yaml PTHR43434 PTN002459629 AN162 ok True PTN001052204 AN0 6 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 murB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/murB/murB-ai-review.yaml PTHR21071 PTN002326094 AN89 ok True PTN001843295 AN0 4 SPECIATION LUCA LUCA True True False 60 1 UniProtKB:P08373 murB GO:0071555 cell wall organization biological_process KEEP_AS_NON_CORE genes/PSEPK/murB/murB-ai-review.yaml PTHR21071 PTN002326094 AN89 ok True PTN001843295 AN0 4 SPECIATION LUCA LUCA True True False 60 1 UniProtKB:P08373 murG GO:0016757 glycosyltransferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/murG/murG-ai-review.yaml PTHR21015 PTN002325814 AN160 ok True PTN000470555 AN0 4 SPECIATION LUCA LUCA True True False 95 1 UniProtKB:P17443 murJ GO:0034204 lipid translocation biological_process ACCEPT genes/PSEPK/murJ/murJ-ai-review.yaml PTHR47019 PTN002257100 AN21 ok True PTN001341949 AN0 3 SPECIATION Eubacteria Eubacteria True True False 19 1 UniProtKB:P0AF16 mutS GO:0003690 double-stranded DNA binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/mutS/mutS-ai-review.yaml PTHR11361 PTN002260821 AN1423 ok True PTN002260779 AN0 6 DUPLICATION True True 752 10 SGD:S000000688|SGD:S000002313|UniProtKB:P43246|UniProtKB:P20585|MGI:MGI:101816|UniProtKB:P52701|SGD:S000005450|MGI:MGI:1343961|SGD:S000001891|SGD:S000002504 mutS GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/mutS/mutS-ai-review.yaml PTHR11361 PTN002260821 AN1423 ok True PTN002260803 AN1371 4 DUPLICATION LUCA True False True 40 1 UniProtKB:P23909 mvaB GO:0006552 L-leucine catabolic process biological_process ACCEPT genes/PSEPK/mvaB/mvaB-ai-review.yaml PTHR42738 PTN002448903 AN349 ok True PTN000031222 AN0 4 SPECIATION LUCA LUCA True True False 183 3 UniProtKB:Q9I2A0|MGI:MGI:96158|UniProtKB:Q5B2F7 mvaB GO:0046951 ketone body biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/mvaB/mvaB-ai-review.yaml PTHR42738 PTN002448903 AN349 ok True PTN000031222 AN0 4 SPECIATION LUCA LUCA True True False 183 5 UniProtKB:P35914|UniProtKB:P35915|FB:FBgn0031877|UniProtKB:Q8TB92|RGD:620554 nadA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/nadA/nadA-ai-review.yaml PTHR30573 PTN002412765 AN148 ok True PTN000778117 AN116 3 SPECIATION Eubacteria Eubacteria True False False 27 1 UniProtKB:P11458 nadA GO:0034628 'de novo' NAD+ biosynthetic process from L-aspartate biological_process ACCEPT genes/PSEPK/nadA/nadA-ai-review.yaml PTHR30573 PTN002412765 AN148 ok True PTN000778111 AN0 4 SPECIATION LUCA LUCA True True False 88 2 UniProtKB:P11458|UniProtKB:P9WJK1 nadB GO:0034628 'de novo' NAD+ biosynthetic process from L-aspartate biological_process ACCEPT genes/PSEPK/nadB/nadB-ai-review.yaml PTHR42716 PTN002448699 AN152 ok True PTN000908494 AN0 5 SPECIATION LUCA LUCA True True True 88 1 UniProtKB:P10902 nadC GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/nadC/nadC-ai-review.yaml PTHR32179 PTN004927553 AN238 no_same_term_ibd_on_path False nadC GO:0034213 quinolinate catabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/nadC/nadC-ai-review.yaml PTHR32179 PTN004927553 AN238 ok True PTN000789406 AN0 5 SPECIATION LUCA LUCA True True True 137 1 UniProtKB:Q15274 nicD GO:0016020 membrane cellular_component REMOVE genes/PSEPK/nicD/nicD-ai-review.yaml PTHR43798 PTN001661081 AN24 ok True PTN001661081 AN24 0 SPECIATION LUCA LUCA True False False 134 1 MGI:MGI:1913332 nicR GO:0006950 response to stress biological_process REMOVE genes/PSEPK/nicR/nicR-ai-review.yaml PTHR33164 PTN008652328 AN101 ok True PTN002109389 AN0 3 SPECIATION LUCA LUCA True True True 229 2 UniProtKB:O34777|UniProtKB:P27245 nicT GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/nicT/nicT-ai-review.yaml PTHR43791 PTN000185216 AN783 ok True PTN002465406 AN773 1 DUPLICATION Proteobacteria True False True 13 2 UniProtKB:P76470|UniProtKB:P32135 nspC GO:0008836 diaminopimelate decarboxylase activity molecular_function REMOVE genes/PSEPK/nspC/nspC-ai-review.yaml PTHR43727 PTN001691018 AN136 ok True PTN000159906 AN0 4 SPECIATION LUCA LUCA True True True 116 4 UniProtKB:Q58497|UniProtKB:P19572|UniProtKB:P9WIU7|UniProtKB:P00861 nuoA GO:0030964 NADH dehydrogenase complex cellular_component ACCEPT genes/PSEPK/nuoA/nuoA-ai-review.yaml PTHR11058 PTN002252969 AN204 ok True PTN000114844 AN0 7 SPECIATION LUCA LUCA True True True 172 6 FB:FBgn0013681|UniProtKB:P92533|UniProtKB:P03897|UniProtKB:P0AFC3|MGI:MGI:102499|UniProtKB:P03898 nuoB GO:0009060 aerobic respiration biological_process KEEP_AS_NON_CORE genes/PSEPK/nuoB/nuoB-ai-review.yaml PTHR11995 PTN002279672 AN399 ok True PTN000242188 AN0 4 SPECIATION LUCA LUCA True True False 225 3 FB:FBgn0030718|UniProtKB:P0AFC7|UniProtKB:O75251 nuoB GO:0015990 electron transport coupled proton transport biological_process ACCEPT genes/PSEPK/nuoB/nuoB-ai-review.yaml PTHR11995 PTN002279672 AN399 ok True PTN000242188 AN0 4 SPECIATION LUCA LUCA True True False 225 1 UniProtKB:P0AFC7 nuoB GO:0045271 respiratory chain complex I cellular_component ACCEPT genes/PSEPK/nuoB/nuoB-ai-review.yaml PTHR11995 PTN002279672 AN399 ok True PTN000242188 AN0 4 SPECIATION LUCA LUCA True True False 225 6 UniProtKB:P42026|UniProtKB:P0AFC7|MGI:MGI:1922656|UniProtKB:O75251|FB:FBgn0039669|FB:FBgn0030718 nuoE GO:0003954 NADH dehydrogenase activity molecular_function MODIFY genes/PSEPK/nuoE/nuoE-ai-review.yaml PTHR10371 PTN002234036 AN257 ok True PTN000042735 AN0 3 SPECIATION Eubacteria Eubacteria True True False 143 2 UniProtKB:P19404|UniProtKB:P0AFD1 nuoG GO:0003954 NADH dehydrogenase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/nuoG/nuoG-ai-review.yaml PTHR43105 PTN002267032 AN68 ok True PTN008678683 AN51 4 SPECIATION Eubacteria Eubacteria True False True 33 1 UniProtKB:P33602 nuoG GO:0022904 respiratory electron transport chain biological_process ACCEPT genes/PSEPK/nuoG/nuoG-ai-review.yaml PTHR43105 PTN002267032 AN68 ok True PTN008678683 AN51 4 SPECIATION Eubacteria Eubacteria True False True 33 2 UniProtKB:P07658|UniProtKB:P33602 nuoH GO:0003954 NADH dehydrogenase activity molecular_function MODIFY genes/PSEPK/nuoH/nuoH-ai-review.yaml PTHR11432 PTN002262020 AN291 ok True PTN000153359 AN0 4 SPECIATION LUCA LUCA True True False 175 1 UniProtKB:P0AFD4 nuoH GO:0009060 aerobic respiration biological_process KEEP_AS_NON_CORE genes/PSEPK/nuoH/nuoH-ai-review.yaml PTHR11432 PTN002262020 AN291 ok True PTN000153359 AN0 4 SPECIATION LUCA LUCA True True False 175 3 UniProtKB:P03886|FB:FBgn0013679|UniProtKB:P0AFD4 nuoI GO:0003954 NADH dehydrogenase activity molecular_function MODIFY genes/PSEPK/nuoI/nuoI-ai-review.yaml PTHR10849 PTN000091339 AN262 ok True PTN000091255 AN1 4 SPECIATION LUCA LUCA True False True 146 2 UniProtKB:P0AFD6|UniProtKB:O00217 nuoI GO:0009060 aerobic respiration biological_process KEEP_AS_NON_CORE genes/PSEPK/nuoI/nuoI-ai-review.yaml PTHR10849 PTN000091339 AN262 ok True PTN000091255 AN1 4 SPECIATION LUCA LUCA True False True 146 4 UniProtKB:P0AFD6|WB:WBGene00020636|FB:FBgn0017567|UniProtKB:O00217 nuoK GO:0030964 NADH dehydrogenase complex cellular_component ACCEPT genes/PSEPK/nuoK/nuoK-ai-review.yaml PTHR11434 PTN002262035 AN308 ok True PTN000153441 AN0 5 SPECIATION LUCA LUCA True True True 183 5 UniProtKB:P03901|UniProtKB:P0AFE4|MGI:MGI:102497|UniProtKB:P03902|FB:FBgn0013683 nuoL GO:0003954 NADH dehydrogenase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/nuoL/nuoL-ai-review.yaml PTHR42829 PTN002450313 AN306 no_same_term_ibd_on_path False nuoL GO:0015990 electron transport coupled proton transport biological_process ACCEPT genes/PSEPK/nuoL/nuoL-ai-review.yaml PTHR42829 PTN002450313 AN306 ok True PTN000511978 AN0 5 SPECIATION LUCA LUCA True True True 179 1 UniProtKB:P33607 nuoM GO:0003954 NADH dehydrogenase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/nuoM/nuoM-ai-review.yaml PTHR43507 PTN002460631 AN278 ok True PTN000511780 AN0 5 SPECIATION LUCA LUCA True True True 163 1 UniProtKB:P0AFE8 nuoM GO:0009060 aerobic respiration biological_process KEEP_AS_NON_CORE genes/PSEPK/nuoM/nuoM-ai-review.yaml PTHR43507 PTN002460631 AN278 ok True PTN000511780 AN0 5 SPECIATION LUCA LUCA True True True 163 3 FB:FBgn0262952|UniProtKB:P0AFE8|UniProtKB:P03905 nuoM GO:0015990 electron transport coupled proton transport biological_process ACCEPT genes/PSEPK/nuoM/nuoM-ai-review.yaml PTHR43507 PTN002460631 AN278 ok True PTN000511780 AN0 5 SPECIATION LUCA LUCA True True True 163 1 UniProtKB:P0AFE8 nuoM GO:0048039 ubiquinone binding molecular_function REMOVE genes/PSEPK/nuoM/nuoM-ai-review.yaml PTHR43507 PTN002460631 AN278 ok True PTN000511780 AN0 5 SPECIATION LUCA LUCA True True True 163 1 UniProtKB:P0AFE8 opgG GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/PSEPK/opgG/opgG-ai-review.yaml PTHR30504 PTN002412129 AN12 ok True PTN001253664 AN0 4 SPECIATION Eubacteria Eubacteria True True True 12 1 UniProtKB:P40120 opgG GO:0051274 beta-glucan biosynthetic process biological_process MODIFY genes/PSEPK/opgG/opgG-ai-review.yaml PTHR30504 PTN002412129 AN12 ok True PTN001253664 AN0 4 SPECIATION Eubacteria Eubacteria True True True 12 1 UniProtKB:P33136 oxyR GO:0032993 protein-DNA complex cellular_component ACCEPT genes/PSEPK/oxyR/oxyR-ai-review.yaml PTHR30346 PTN002411105 AN127 ok True PTN001576272 AN2 6 DUPLICATION False True 110 2 UniProtKB:Q9K1H8|UniProtKB:Q9HTL4 paaA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/paaA/paaA-ai-review.yaml PTHR30458 PTN000765279 AN18 ok True PTN001252629 AN0 3 SPECIATION LUCA LUCA True True True 14 1 UniProtKB:P76079 paaC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/paaC/paaC-ai-review.yaml PTHR30458 PTN000765275 AN12 ok True PTN001252629 AN0 3 SPECIATION LUCA LUCA True True True 14 1 UniProtKB:P76079 paaE GO:0050660 flavin adenine dinucleotide binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/paaE/paaE-ai-review.yaml PTHR47354 PTN001064860 AN87 ok True PTN000452442 AN72 3 SPECIATION Eubacteria Eubacteria True False False 10 2 UniProtKB:P76081|UniProtKB:P9WJ93 paaF GO:0006635 fatty acid beta-oxidation biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/paaF/paaF-ai-review.yaml PTHR11941 PTN000235251 AN3 ok True PTN000941828 AN0 3 SPECIATION LUCA LUCA True True False 560 4 RGD:69330|MGI:MGI:94871|UniProtKB:P30084|RGD:61892 paaH GO:0006635 fatty acid beta-oxidation biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/paaH/paaH-ai-review.yaml PTHR48075 PTN000592971 AN293 ok True PTN008732775 AN269 4 SPECIATION Eubacteria Eubacteria True False False 16 1 UniProtKB:P9WNP7 paaJ GO:0006635 fatty acid beta-oxidation biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/paaJ/paaJ-ai-review.yaml PTHR43853 PTN001291485 AN360 ok True PTN001823071 AN0 6 SPECIATION LUCA LUCA True True True 204 5 RGD:67379|UniProtKB:P21151|SGD:S000001422|UniProtKB:P09110|MGI:MGI:3605455 paaJ GO:0010124 phenylacetate catabolic process biological_process ACCEPT genes/PSEPK/paaJ/paaJ-ai-review.yaml PTHR43853 PTN001291485 AN360 no_same_term_ibd_on_path False pabA GO:0000162 L-tryptophan biosynthetic process biological_process ACCEPT genes/PSEPK/pabA/pabA-ai-review.yaml PTHR43418 PTN002459382 AN258 ok True PTN000230074 AN10 5 SPECIATION LUCA LUCA True False True 149 8 UniProtKB:P20576|UniProtKB:P28819|PomBase:SPBC1539.09c|SGD:S000001694|UniProtKB:Q7XUS2|UniProtKB:P00904|UniProtKB:Q764B9|AGI_LocusCode:AT1G25220 pabA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pabA/pabA-ai-review.yaml PTHR43418 PTN002459382 AN258 no_same_term_ibd_on_path False pabA GO:0046654 tetrahydrofolate biosynthetic process biological_process UNDECIDED genes/PSEPK/pabA/pabA-ai-review.yaml PTHR43418 PTN002459382 AN258 ok True PTN000747575 AN252 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 9 1 UniProtKB:P00903 panB GO:0000287 magnesium ion binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/panB/panB-ai-review.yaml PTHR20881 PTN004525384 AN217 ok True PTN000466854 AN0 5 SPECIATION LUCA LUCA True True False 130 2 UniProtKB:P9WIL7|UniProtKB:P31057 panC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/panC/panC-ai-review.yaml PTHR21299 PTN002327662 AN214 ok True PTN000480630 AN35 5 DUPLICATION LUCA True False True 113 3 AGI_LocusCode:AT5G48840|UniProtKB:P0A6I0|UniProtKB:P31663 panE GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/panE/panE-ai-review.yaml PTHR43765 PTN002464842 AN6 ok True PTN002464833 AN0 4 SPECIATION LUCA LUCA True True False 47 1 SGD:S000002605 panE GO:0050661 NADP binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/panE/panE-ai-review.yaml PTHR43765 PTN002464842 AN6 ok True PTN002464833 AN0 4 SPECIATION LUCA LUCA True True False 47 1 UniProtKB:P0A9J4 pcaK GO:0046942 carboxylic acid transport biological_process MODIFY genes/PSEPK/pcaK/pcaK-ai-review.yaml PTHR23508 PTN002781836 AN88 no_same_term_ibd_on_path False pcaK GO:0046943 carboxylic acid transmembrane transporter activity molecular_function MODIFY genes/PSEPK/pcaK/pcaK-ai-review.yaml PTHR23508 PTN002781836 AN88 no_same_term_ibd_on_path False pcaQ GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pcaQ/pcaQ-ai-review.yaml PTHR30419 PTN002019178 AN70 ok True PTN000790637 AN0 5 DUPLICATION True True 58 1 UniProtKB:P0ACR7 pdxB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pdxB/pdxB-ai-review.yaml PTHR42938 PTN002452155 AN937 ok True PTN000107798 AN933 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P05459 pdxB GO:0036001 'de novo' pyridoxal 5'-phosphate biosynthetic process biological_process ACCEPT genes/PSEPK/pdxB/pdxB-ai-review.yaml PTHR42938 PTN002452155 AN937 ok True PTN000107798 AN933 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P05459 pdxH GO:0042823 pyridoxal 5'-phosphate biosynthetic process biological_process ACCEPT genes/PSEPK/pdxH/pdxH-ai-review.yaml PTHR10851 PTN002247547 AN279 ok True PTN000091366 AN0 6 SPECIATION LUCA LUCA True True True 152 5 UniProtKB:P9WIJ1|UniProtKB:P0AFI7|FB:FBgn0051472|UniProtKB:Q9NVS9|AGI_LocusCode:AT2G46580 pdxJ GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pdxJ/pdxJ-ai-review.yaml PTHR30456 PTN002411800 AN19 ok True PTN000765245 AN0 3 SPECIATION Eubacteria Eubacteria True True False 19 1 UniProtKB:P0A794 pgi1 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pgi1/pgi1-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 6 UniProtKB:P42863|UniProtKB:P0A6T1|AGI_LocusCode:AT5G42740|FB:FBgn0003074|MGI:MGI:95797|UniProtKB:P42862 pgi1 GO:0048029 monosaccharide binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/pgi1/pgi1-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 1 RGD:2727 pgi1 GO:0051156 glucose 6-phosphate metabolic process biological_process ACCEPT genes/PSEPK/pgi1/pgi1-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 5 RGD:2727|UniProtKB:P06744|MGI:MGI:95797|FB:FBgn0003074|SGD:S000000400 pgi2 GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pgi2/pgi2-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 6 UniProtKB:P42863|UniProtKB:P0A6T1|AGI_LocusCode:AT5G42740|FB:FBgn0003074|MGI:MGI:95797|UniProtKB:P42862 pgi2 GO:0048029 monosaccharide binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/pgi2/pgi2-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 1 RGD:2727 pgi2 GO:0051156 glucose 6-phosphate metabolic process biological_process ACCEPT genes/PSEPK/pgi2/pgi2-ai-review.yaml PTHR11469 PTN002263072 AN402 ok True PTN000157839 AN0 4 SPECIATION LUCA LUCA True True False 214 5 RGD:2727|UniProtKB:P06744|MGI:MGI:95797|FB:FBgn0003074|SGD:S000000400 pgk GO:0005524 ATP binding molecular_function ACCEPT genes/PSEPK/pgk/pgk-ai-review.yaml PTHR11406 PTN002261394 AN582 ok True PTN000150497 AN0 4 SPECIATION LUCA LUCA True True False 323 2 UniProtKB:P00559|RGD:619878 pgk GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pgk/pgk-ai-review.yaml PTHR11406 PTN002261394 AN582 ok True PTN000150497 AN0 4 SPECIATION LUCA LUCA True True False 323 4 AGI_LocusCode:AT1G79550|UniProtKB:P0A799|MGI:MGI:97555|UniProtKB:P00558 pgk GO:0006094 gluconeogenesis biological_process ACCEPT genes/PSEPK/pgk/pgk-ai-review.yaml PTHR11406 PTN002261394 AN582 ok True PTN000150497 AN0 4 SPECIATION LUCA LUCA True True False 323 3 RGD:619878|SGD:S000000605|MGI:MGI:97555 pgk GO:0043531 ADP binding molecular_function ACCEPT genes/PSEPK/pgk/pgk-ai-review.yaml PTHR11406 PTN002261394 AN582 ok True PTN000150497 AN0 4 SPECIATION LUCA LUCA True True False 323 2 UniProtKB:Q4QD34|RGD:619878 pgm GO:0006166 purine ribonucleoside salvage biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pgm/pgm-ai-review.yaml PTHR45745 PTN000501512 AN202 ok True PTN001860097 AN0 3 SPECIATION LUCA LUCA True True False 110 1 SGD:S000004891 pgm GO:0008973 phosphopentomutase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/pgm/pgm-ai-review.yaml PTHR45745 PTN000501512 AN202 ok True PTN001860097 AN0 3 SPECIATION LUCA LUCA True True False 110 2 UniProtKB:Q96G03|SGD:S000004891 pgsA GO:0005886 plasma membrane cellular_component ACCEPT genes/PSEPK/pgsA/pgsA-ai-review.yaml PTHR14269 PTN002306877 AN657 ok True PTN000370517 AN652 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 8 1 UniProtKB:P0ABF8 pgsA GO:0046474 glycerophospholipid biosynthetic process biological_process ACCEPT genes/PSEPK/pgsA/pgsA-ai-review.yaml PTHR14269 PTN002306877 AN657 ok True PTN000370359 AN1 6 SPECIATION LUCA LUCA True False True 346 11 AGI_LocusCode:AT2G39290|PomBase:SPAC22A12.08c|MGI:MGI:1913836|AGI_LocusCode:AT3G55030|UniProtKB:Q9UJA2|UniProtKB:Q9KZP3|UniProtKB:A0A2K3D1C8|AGI_LocusCode:AT4G04870|UniProtKB:P9WPG3|WB:WBGene00017763|FB:FBgn0039360 phaZ GO:0004806 triacylglycerol lipase activity molecular_function MODIFY genes/PSEPK/phaZ/phaZ-ai-review.yaml PTHR43433 PTN002251178 AN119 ok True PTN001335022 AN99 5 SPECIATION Eubacteria Eubacteria True False True 13 1 UniProtKB:P96935 phaZ GO:0046503 glycerolipid catabolic process biological_process MODIFY genes/PSEPK/phaZ/phaZ-ai-review.yaml PTHR43433 PTN002251178 AN119 ok True PTN001335022 AN99 5 SPECIATION Eubacteria Eubacteria True False True 13 1 UniProtKB:P96935 pheT GO:0009328 phenylalanine-tRNA ligase complex cellular_component ACCEPT genes/PSEPK/pheT/pheT-ai-review.yaml PTHR10947 PTN002250123 AN368 ok True PTN000101805 AN0 4 SPECIATION LUCA LUCA True True False 206 3 UniProtKB:Q9NSD9|SGD:S000004050|UniProtKB:P07395 phnX GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/phnX/phnX-ai-review.yaml PTHR43434 PTN002455951 AN88 ok True PTN001291474 AN57 4 DUPLICATION LUCA True False True 80 1 UniProtKB:P32662 phnX GO:0006281 DNA repair biological_process REMOVE genes/PSEPK/phnX/phnX-ai-review.yaml PTHR43434 PTN002455951 AN88 ok True PTN001052204 AN0 5 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 phnX GO:0008967 phosphoglycolate phosphatase activity molecular_function REMOVE genes/PSEPK/phnX/phnX-ai-review.yaml PTHR43434 PTN002455951 AN88 ok True PTN001052204 AN0 5 SPECIATION LUCA LUCA True True True 113 1 UniProtKB:P32662 pncB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pncB/pncB-ai-review.yaml PTHR11098 PTN002254641 AN298 ok True PTN008512301 AN0 6 SPECIATION LUCA LUCA True True False 164 3 MGI:MGI:2442664|UniProtKB:P18133|UniProtKB:Q6XQN6 pncB GO:0034355 NAD+ biosynthetic process via the salvage pathway biological_process ACCEPT genes/PSEPK/pncB/pncB-ai-review.yaml PTHR11098 PTN002254641 AN298 ok True PTN008512301 AN0 6 SPECIATION LUCA LUCA True True False 164 4 UniProtKB:Q6XQN6|UniProtKB:P9WJI7|MGI:MGI:2442664|UniProtKB:P9WJI9 pnp GO:0000175 3'-5'-RNA exonuclease activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/pnp/pnp-ai-review.yaml PTHR11252 PTN002258016 AN320 ok True PTN000134193 AN0 5 SPECIATION LUCA LUCA True True False 175 4 AGI_LocusCode:AT3G03710|AGI_LocusCode:AT5G14580|UniProtKB:Q8TCS8|UniProtKB:P05055 pnp GO:0006401 RNA catabolic process biological_process ACCEPT genes/PSEPK/pnp/pnp-ai-review.yaml PTHR11252 PTN002258016 AN320 ok True PTN000134193 AN0 5 SPECIATION LUCA LUCA True True False 175 5 AGI_LocusCode:AT3G03710|MGI:MGI:1918951|UniProtKB:Q8TCS8|AGI_LocusCode:AT5G14580|FB:FBgn0039846 ppc GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/ppc/ppc-ai-review.yaml PTHR30523 PTN002412316 AN16 ok True PTN000776118 AN0 5 SPECIATION LUCA LUCA True True False 252 1 UniProtKB:P00864 ppnP GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ppnP/ppnP-ai-review.yaml PTHR36540 PTN002443144 AN11 ok True PTN002194962 AN0 4 SPECIATION LUCA LUCA True True False 11 1 UniProtKB:P0C037 proB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/proB/proB-ai-review.yaml PTHR43654 PTN002462614 AN196 ok True PTN000115542 AN0 5 SPECIATION LUCA LUCA True True False 112 3 UniProtKB:P0A7B5|SGD:S000002708|AGI_LocusCode:AT1G26640 proS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/proS/proS-ai-review.yaml PTHR42753 PTN002449069 AN213 ok True PTN000155068 AN174 3 SPECIATION Eubacteria Eubacteria True False False 31 1 UniProtKB:P16659 prpC GO:0005975 carbohydrate metabolic process biological_process REMOVE genes/PSEPK/prpC/prpC-ai-review.yaml PTHR11739 PTN002271895 AN18 ok True PTN000201223 AN0 8 SPECIATION LUCA LUCA True True True 270 1 UniProtKB:O75390 prs GO:0002189 ribose phosphate diphosphokinase complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/prs/prs-ai-review.yaml PTHR10210 PTN002230601 AN928 ok True PTN000025022 AN0 5 SPECIATION LUCA LUCA True True True 495 9 RGD:620206|SGD:S000005422|RGD:3415|SGD:S000001664|SGD:S000000901|SGD:S000000164|RGD:620207|RGD:61955|SGD:S000001003 prs GO:0006164 purine nucleotide biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/prs/prs-ai-review.yaml PTHR10210 PTN002230601 AN928 ok True PTN000025022 AN0 5 SPECIATION LUCA LUCA True True True 495 4 RGD:3415|RGD:61955|UniProtKB:P11908|UniProtKB:P60891 pssA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pssA/pssA-ai-review.yaml PTHR12586 PTN001758495 AN1 ok True PTN001758495 AN1 0 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P23830 ptsN GO:0030295 protein kinase activator activity molecular_function MODIFY genes/PSEPK/ptsN/ptsN-ai-review.yaml PTHR47738 PTN002412134 AN42 ok True PTN002021052 AN27 3 SPECIATION Eubacteria Eubacteria True False False 17 1 UniProtKB:P69829 ptxD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ptxD/ptxD-ai-review.yaml PTHR10996 PTN002251374 AN969 ok True PTN000107947 AN1 6 SPECIATION LUCA LUCA True False True 539 2 UniProtKB:P37666|UniProtKB:P75913 ptxD GO:0016618 hydroxypyruvate reductase [NAD(P)H] activity molecular_function UNDECIDED genes/PSEPK/ptxD/ptxD-ai-review.yaml PTHR10996 PTN002251374 AN969 ok True PTN000107947 AN1 6 SPECIATION LUCA LUCA True False True 539 8 SGD:S000005218|AGI_LocusCode:AT1G79870|UniProtKB:A5CAL1|AGI_LocusCode:AT1G68010|UniProtKB:P75913|AGI_LocusCode:AT1G12550|UniProtKB:Q9UBQ7|RGD:1308851 ptxD GO:0030267 glyoxylate reductase (NADPH) activity molecular_function UNDECIDED genes/PSEPK/ptxD/ptxD-ai-review.yaml PTHR10996 PTN002251374 AN969 ok True PTN000107947 AN1 6 SPECIATION LUCA LUCA True False True 539 8 AGI_LocusCode:AT1G12550|UniProtKB:P37666|UniProtKB:P75913|RGD:1308851|UniProtKB:Q9UBQ7|UniProtKB:A5CAL1|AGI_LocusCode:AT1G79870|SGD:S000005218 ptxS GO:0003700 DNA-binding transcription factor activity molecular_function MODIFY genes/PSEPK/ptxS/ptxS-ai-review.yaml PTHR30146 PTN002409864 AN340 ok True PTN001248758 AN0 7 SPECIATION LUCA LUCA True True True 219 11 UniProtKB:P03023|UniProtKB:P18811|UniProtKB:P0ACI3|UniProtKB:P0ACQ0|UniProtKB:P0ACP7|UniProtKB:G3XD97|UniProtKB:Q8EBJ8|UniProtKB:Q9I1F6|UniProtKB:P24242|UniProtKB:P36673|UniProtKB:P25144 purB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purB/purB-ai-review.yaml PTHR43411 PTN002459269 AN157 ok True PTN000154671 AN151 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 9 1 UniProtKB:P0AB89 purC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purC/purC-ai-review.yaml PTHR43599 PTN002461905 AN153 ok True PTN009171110 AN34 4 SPECIATION Eubacteria Eubacteria True False True 68 1 UniProtKB:P0A7D7 purH GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purH/purH-ai-review.yaml PTHR11692 PTN002269566 AN285 ok True PTN000190296 AN0 5 SPECIATION LUCA LUCA True True False 159 3 SGD:S000004727|SGD:S000004018|UniProtKB:P15639 purK GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purK/purK-ai-review.yaml PTHR11609 PTN008521733 AN195 ok True PTN008521729 AN156 3 SPECIATION Eubacteria Eubacteria True False False 29 1 UniProtKB:P09029 purM GO:0004637 phosphoribosylamine-glycine ligase activity molecular_function REMOVE genes/PSEPK/purM/purM-ai-review.yaml PTHR10520 PTN002237315 AN304 ok True PTN000055158 AN0 5 SPECIATION LUCA LUCA True True False 170 4 RGD:1308717|PomBase:SPBC405.01|MGI:MGI:95654|FB:FBgn0000053 purM GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/purM/purM-ai-review.yaml PTHR10520 PTN002237315 AN304 ok True PTN000055158 AN0 5 SPECIATION LUCA LUCA True True False 170 3 UniProtKB:P08178|MGI:MGI:95654|UniProtKB:P22102 purM GO:0006164 purine nucleotide biosynthetic process biological_process ACCEPT genes/PSEPK/purM/purM-ai-review.yaml PTHR10520 PTN002237315 AN304 ok True PTN000055158 AN0 5 SPECIATION LUCA LUCA True True False 170 3 PomBase:SPBC405.01|MGI:MGI:95654|UniProtKB:P22102 purM GO:0046084 adenine biosynthetic process biological_process ACCEPT genes/PSEPK/purM/purM-ai-review.yaml PTHR10520 PTN002237315 AN304 ok True PTN000055158 AN0 5 SPECIATION LUCA LUCA True True False 170 1 CGD:CAL0000199243 purN GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/purN/purN-ai-review.yaml PTHR43369 PTN002458705 AN189 ok True PTN000055290 AN0 4 SPECIATION LUCA LUCA True True False 112 1 UniProtKB:P08179 purN GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purN/purN-ai-review.yaml PTHR43369 PTN002458705 AN189 ok True PTN000055315 AN146 3 SPECIATION Eubacteria Eubacteria True False False 35 1 UniProtKB:P08179 purT GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/purT/purT-ai-review.yaml PTHR43055 PTN002453612 AN16 ok True PTN000549240 AN0 5 SPECIATION LUCA LUCA True True False 20 1 UniProtKB:P33221 putP GO:0015193 L-proline transmembrane transporter activity molecular_function MODIFY genes/PSEPK/putP/putP-ai-review.yaml PTHR48086 PTN005155986 AN138 ok True PTN001371338 AN113 3 SPECIATION Eubacteria Eubacteria True False False 20 2 UniProtKB:P94392|UniProtKB:Q9I5F5 puuA-I GO:0006598 polyamine catabolic process biological_process MODIFY genes/PSEPK/puuA-I/puuA-I-ai-review.yaml PTHR43785 PTN000465124 AN256 ok True PTN001839150 AN255 1 DUPLICATION Proteobacteria True False True 10 4 UniProtKB:P78061|UniProtKB:Q9I3F1|UniProtKB:Q9I6J5|UniProtKB:Q9I6J3 puuB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/puuB/puuB-ai-review.yaml PTHR13847 PTN002302720 AN370 ok True PTN000354057 AN0 7 DUPLICATION True True 460 10 RGD:621125|FB:FBgn0002021|UniProtKB:Q9UI17|UniProtKB:O46504|UniProtKB:P33940|UniProtKB:Q5JFG7|UniProtKB:Q96CU9|MGI:MGI:2183102|UniProtKB:Q38A60|SGD:S000001051 pvdA GO:0006879 intracellular iron ion homeostasis biological_process MODIFY genes/PSEPK/pvdA/pvdA-ai-review.yaml PTHR42802 PTN002346172 AN5 ok True PTN001009003 AN2 3 SPECIATION Dikarya Dikarya False False False 11 3 PomBase:SPAC23G3.03|UniProtKB:G5EB76|UniProtKB:E9QYP0 pvdD GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/pvdD/pvdD-ai-review.yaml PTHR45527 PTN005148629 AN130 ok True PTN002378821 AN0 5 SPECIATION LUCA LUCA True True True 78 2 UniProtKB:Q4WLW8|UniProtKB:P11454 pvdD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pvdD/pvdD-ai-review.yaml PTHR45527 PTN005148629 AN130 ok True PTN002378851 AN97 3 SPECIATION Eubacteria Eubacteria True False False 25 1 UniProtKB:P11454 pvdD GO:0009239 enterobactin biosynthetic process biological_process MODIFY genes/PSEPK/pvdD/pvdD-ai-review.yaml PTHR45527 PTN005148629 AN130 ok True PTN002378853 AN128 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P11454 pvdD GO:0009366 enterobactin synthetase complex cellular_component REMOVE genes/PSEPK/pvdD/pvdD-ai-review.yaml PTHR45527 PTN005148629 AN130 ok True PTN002378853 AN128 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P11454 pvdD GO:0047527 2,3-dihydroxybenzoate-serine ligase activity molecular_function MODIFY genes/PSEPK/pvdD/pvdD-ai-review.yaml PTHR45527 PTN005148629 AN130 ok True PTN002378853 AN128 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P11454 pvdE GO:0034040 ATPase-coupled lipid transmembrane transporter activity molecular_function REMOVE genes/PSEPK/pvdE/pvdE-ai-review.yaml PTHR24221 PTN000657720 AN2895 ok True PTN000657720 AN2895 0 SPECIATION Eubacteria Eubacteria True False False 154 1 UniProtKB:P60752 pvdE GO:0042626 ATPase-coupled transmembrane transporter activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/pvdE/pvdE-ai-review.yaml PTHR24221 PTN000657720 AN2895 ok True PTN000657189 AN0 2 SPECIATION LUCA LUCA True True True 1769 25 UniProtKB:P08183|UniProtKB:P29018|PomBase:SPCC663.03|UniProtKB:B8K1W2|SGD:S000004916|UniProtKB:P21439|UniProtKB:Q2M3G0|UniProtKB:Q9NP58|UniProtKB:O95342|AGI_LocusCode:AT3G28860|UniProtKB:Q03519|MGI:MGI:1921354|FB:FBgn0004513|UniProtKB:Q9NP78|MGI:MGI:97570|UniProtKB:P60752|RGD:619930|UniProtKB:O75027|MGI:MGI:98483|CGD:CAL0000187443|PomBase:SPBC25B2.02c|PomBase:SPCC737.09c|AGI_LocusCode:AT2G47000|UniProtKB:Q03518|ZFIN:ZDB-GENE-080204-52 pycB GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/pycB/pycB-ai-review.yaml PTHR43778 PTN001821756 AN118 no_same_term_ibd_on_path False pycB GO:0006094 gluconeogenesis biological_process ACCEPT genes/PSEPK/pycB/pycB-ai-review.yaml PTHR43778 PTN001821756 AN118 ok True PTN001821692 AN0 3 SPECIATION LUCA LUCA True True False 67 4 SGD:S000000422|RGD:3262|MGI:MGI:97520|SGD:S000003030 pydB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/pydB/pydB-ai-review.yaml PTHR11647 PTN002267994 AN469 ok True PTN000182670 AN34 4 SPECIATION Eubacteria Eubacteria True False False 229 6 RGD:68376|MGI:MGI:1928679|UniProtKB:Q16555|UniProtKB:Q14194|RGD:2410|ZFIN:ZDB-GENE-031105-1 pydB GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides molecular_function KEEP_AS_NON_CORE genes/PSEPK/pydB/pydB-ai-review.yaml PTHR11647 PTN002267994 AN469 ok True PTN000182670 AN34 4 SPECIATION Eubacteria Eubacteria True False False 229 9 RGD:68376|MGI:MGI:1928679|WB:WBGene00000964|AGI_LocusCode:AT5G12200|UniProtKB:Q46806|UniProtKB:Q14117|WB:WBGene00000963|dictyBase:DDB_G0269246|FB:FBgn0023023 pyrB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrB/pyrB-ai-review.yaml PTHR45753 PTN002261367 AN60 no_same_term_ibd_on_path False pyrC' GO:0004038 allantoinase activity molecular_function REMOVE genes/PSEPK/pyrC'/pyrC'-ai-review.yaml PTHR43668 PTN002462795 AN220 not_ibd_on_path False pyrC' GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrC'/pyrC'-ai-review.yaml PTHR43668 PTN002462795 AN220 ok True PTN002462789 AN191 3 DUPLICATION LUCA True False True 34 1 UniProtKB:P77671 pyrC' GO:0006145 purine nucleobase catabolic process biological_process REMOVE genes/PSEPK/pyrC'/pyrC'-ai-review.yaml PTHR43668 PTN002462795 AN220 not_ibd_on_path False pyrC GO:0005737 cytoplasm cellular_component MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrC/pyrC-ai-review.yaml PTHR43137 PTN002455102 AN145 no_same_term_ibd_on_path False pyrC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrC/pyrC-ai-review.yaml PTHR43137 PTN002455102 AN145 ok True PTN000791132 AN134 4 SPECIATION Eubacteria Eubacteria True False False 11 1 UniProtKB:P05020 pyrC GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrC/pyrC-ai-review.yaml PTHR43137 PTN002455102 AN145 ok True PTN000791117 AN0 5 SPECIATION LUCA LUCA True True False 79 3 UniProtKB:P05020|UniProtKB:C8VUF6|SGD:S000004412 pyrC GO:0006221 pyrimidine nucleotide biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrC/pyrC-ai-review.yaml PTHR43137 PTN002455102 AN145 ok True PTN000791117 AN0 5 SPECIATION LUCA LUCA True True False 79 2 SGD:S000004412|UniProtKB:C8VUF6 pyrD GO:0009220 pyrimidine ribonucleotide biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrD/pyrD-ai-review.yaml PTHR48109 PTN002460755 AN313 ok True PTN000234184 AN65 4 SPECIATION LUCA LUCA True False False 136 3 AGI_LocusCode:AT5G23300|MGI:MGI:1928378|PomBase:SPAC57A10.12c pyrE GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrE/pyrE-ai-review.yaml PTHR46683 PTN002319174 AN40 ok True PTN002928258 AN0 6 SPECIATION Eukaryota Eukaryota False True False 26 1 UniProtKB:P0A7E3 pyrE GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrE/pyrE-ai-review.yaml PTHR46683 PTN002319174 AN40 ok True PTN002928258 AN0 6 SPECIATION Eukaryota Eukaryota False True False 26 5 PomBase:SPBC725.15|SGD:S000004574|UniProtKB:Q5B0P6|SGD:S000004884|UniProtKB:P0A7E3 pyrE GO:0046132 pyrimidine ribonucleoside biosynthetic process biological_process REMOVE genes/PSEPK/pyrE/pyrE-ai-review.yaml PTHR46683 PTN002319174 AN40 ok True PTN002928258 AN0 6 SPECIATION Eukaryota Eukaryota False True False 26 2 SGD:S000004574|SGD:S000004884 pyrF GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrF/pyrF-ai-review.yaml PTHR32119 PTN002425383 AN73 ok True PTN001280965 AN0 4 SPECIATION LUCA LUCA True True False 49 2 UniProtKB:P08244|SGD:S000000747 pyrG GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/pyrG/pyrG-ai-review.yaml PTHR11550 PTN000167579 AN563 ok True PTN000167583 AN516 3 SPECIATION Eubacteria Eubacteria True False False 37 1 UniProtKB:P0A7E5 pyrG GO:0019856 pyrimidine nucleobase biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/pyrG/pyrG-ai-review.yaml PTHR11550 PTN000167579 AN563 ok True PTN000167473 AN0 4 SPECIATION LUCA LUCA True True False 310 1 SGD:S000000135 pyrG GO:0042802 identical protein binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/pyrG/pyrG-ai-review.yaml PTHR11550 PTN000167579 AN563 ok True PTN000167473 AN0 4 SPECIATION LUCA LUCA True True False 310 3 UniProtKB:P0A7E5|UniProtKB:Q9NRF8|UniProtKB:P17812 queA GO:0002099 tRNA wobble guanine modification biological_process ACCEPT genes/PSEPK/queA/queA-ai-review.yaml PTHR30307 PTN002410836 AN40 ok True PTN000767999 AN0 4 SPECIATION Eubacteria Eubacteria True True False 34 1 UniProtKB:P0A7F9 quiA GO:0008876 quinoprotein glucose dehydrogenase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/quiA/quiA-ai-review.yaml PTHR32303 PTN004940506 AN15 ok True PTN000793792 AN13 2 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 6 1 UniProtKB:P15877 rbsD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rbsD/rbsD-ai-review.yaml PTHR37831 PTN002208841 AN8 ok True PTN002208836 AN0 1 SPECIATION Eubacteria Eubacteria True True False 9 1 UniProtKB:P04982 rbsD GO:0016866 intramolecular transferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/rbsD/rbsD-ai-review.yaml PTHR37831 PTN002208841 AN8 ok True PTN002208836 AN0 1 SPECIATION Eubacteria Eubacteria True True False 9 1 UniProtKB:P04982 rbsK GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rbsK/rbsK-ai-review.yaml PTHR10584 PTN002238727 AN302 ok True PTN000061929 AN0 6 SPECIATION LUCA LUCA True True True 171 1 UniProtKB:P0A9J6 rbsR GO:0000976 transcription cis-regulatory region binding molecular_function ACCEPT genes/PSEPK/rbsR/rbsR-ai-review.yaml PTHR30146 PTN002409903 AN313 ok True PTN001248758 AN0 6 SPECIATION LUCA LUCA True True True 219 9 UniProtKB:Q8EBJ8|UniProtKB:G3XD97|UniProtKB:P25144|UniProtKB:P77615|UniProtKB:P18811|UniProtKB:P03023|UniProtKB:P0ACP1|UniProtKB:P0ACN7|UniProtKB:P0ACQ0 rbsR GO:0003700 DNA-binding transcription factor activity molecular_function MODIFY genes/PSEPK/rbsR/rbsR-ai-review.yaml PTHR30146 PTN002409903 AN313 ok True PTN001248758 AN0 6 SPECIATION LUCA LUCA True True True 219 11 UniProtKB:P03023|UniProtKB:P18811|UniProtKB:P0ACI3|UniProtKB:P0ACQ0|UniProtKB:P0ACP7|UniProtKB:G3XD97|UniProtKB:Q8EBJ8|UniProtKB:Q9I1F6|UniProtKB:P24242|UniProtKB:P36673|UniProtKB:P25144 recA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/recA/recA-ai-review.yaml PTHR45900 PTN002342393 AN354 no_same_term_ibd_on_path False recB GO:0000725 recombinational repair biological_process KEEP_AS_NON_CORE genes/PSEPK/recB/recB-ai-review.yaml PTHR11070 PTN002253341 AN279 ok True PTN000116141 AN1 6 SPECIATION LUCA LUCA True False True 245 5 UniProtKB:F1ND48|SGD:S000003628|PomBase:SPBC336.01|PomBase:SPAC4H3.05|UniProtKB:P08394 recB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/recB/recB-ai-review.yaml PTHR11070 PTN002253341 AN279 ok True PTN000869814 AN230 4 DUPLICATION LUCA True False True 124 2 UniProtKB:P03018|UniProtKB:P15038 recB GO:0009338 exodeoxyribonuclease V complex cellular_component ACCEPT genes/PSEPK/recB/recB-ai-review.yaml PTHR11070 PTN002253341 AN279 ok True PTN000116249 AN266 3 SPECIATION Eubacteria Eubacteria True False False 14 1 UniProtKB:P08394 recC GO:0006310 DNA recombination biological_process ACCEPT genes/PSEPK/recC/recC-ai-review.yaml PTHR30591 PTN002412877 AN20 ok True PTN001255136 AN0 3 SPECIATION Eubacteria Eubacteria True True False 17 1 UniProtKB:P07648 recD GO:0017116 single-stranded DNA helicase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/recD/recD-ai-review.yaml PTHR43788 PTN002465246 AN85 ok True PTN008452915 AN1 4 SPECIATION LUCA LUCA True False False 51 2 UniProtKB:P04993|UniProtKB:Q8NG08 relA GO:0005886 plasma membrane cellular_component MARK_AS_OVER_ANNOTATED genes/PSEPK/relA/relA-ai-review.yaml PTHR21262 PTN002327464 AN374 no_same_term_ibd_on_path False relA GO:0008728 GTP diphosphokinase activity molecular_function ACCEPT genes/PSEPK/relA/relA-ai-review.yaml PTHR21262 PTN002327464 AN374 ok True PTN001083175 AN365 3 DUPLICATION Eubacteria True False True 23 1 UniProtKB:P0AG20 relA GO:0008893 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/relA/relA-ai-review.yaml PTHR21262 PTN002327464 AN374 ok True PTN001083175 AN365 3 DUPLICATION Eubacteria True False True 23 1 UniProtKB:P0AG24 relA GO:0042594 response to starvation biological_process ACCEPT genes/PSEPK/relA/relA-ai-review.yaml PTHR21262 PTN002327464 AN374 ok True PTN001083175 AN365 3 DUPLICATION Eubacteria True False True 23 1 UniProtKB:Q9I524 retS GO:0071474 cellular hyperosmotic response biological_process UNDECIDED genes/PSEPK/retS/retS-ai-review.yaml PTHR45339 PTN009177399 AN14 ok True PTN000703787 AN12 2 SPECIATION Unikonts Unikonts False False False 15 1 UniProtKB:C8V8F5 rfbC GO:0000271 polysaccharide biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/rfbC/rfbC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 rfbC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rfbC/rfbC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 1 UniProtKB:P37745 rfbC GO:0016854 racemase and epimerase activity molecular_function MODIFY genes/PSEPK/rfbC/rfbC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 rfbD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rfbD/rfbD-ai-review.yaml PTHR10491 PTN000051869 AN121 ok True PTN000051855 AN93 2 SPECIATION Eubacteria Eubacteria True False False 24 1 UniProtKB:P37760 rhlB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rhlB/rhlB-ai-review.yaml PTHR47959 PTN002773555 AN266 ok True PTN008723499 AN0 7 DUPLICATION True True 172 3 UniProtKB:P25888|UniProtKB:P21507|UniProtKB:P0A8J8 rhlE GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rhlE/rhlE-ai-review.yaml PTHR47959 PTN002773588 AN298 ok True PTN008723499 AN0 9 DUPLICATION True True 172 3 UniProtKB:P25888|UniProtKB:P21507|UniProtKB:P0A8J8 rlmE GO:0008173 RNA methyltransferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/rlmE/rlmE-ai-review.yaml PTHR10920 PTN002249808 AN359 ok True PTN000100321 AN0 10 SPECIATION Archaea-Eukaryota Archaea-Eukaryota False True True 376 10 SGD:S000003104|FB:FBgn0038861|SGD:S000000265|SGD:S000000559|UniProtKB:P0C0R7|FB:FBgn0038471|UniProtKB:Q8IY81|UniProtKB:Q9UET6|PomBase:SPAC4F10.03c|UniProtKB:Q9UI43 rmlC GO:0000271 polysaccharide biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/rmlC/rmlC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 rmlC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/rmlC/rmlC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 1 UniProtKB:P37745 rmlC GO:0016854 racemase and epimerase activity molecular_function MODIFY genes/PSEPK/rmlC/rmlC-ai-review.yaml PTHR21047 PTN004530085 AN56 ok True PTN000471580 AN0 4 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 rnc GO:0003725 double-stranded RNA binding molecular_function ACCEPT genes/PSEPK/rnc/rnc-ai-review.yaml PTHR11207 PTN002257160 AN608 ok True PTN000129453 AN0 4 SPECIATION LUCA LUCA True True False 330 5 dictyBase:DDB_G0269426|UniProtKB:Q0IQN6|UniProtKB:A6YSL1|PomBase:SPBC119.11c|AGI_LocusCode:AT1G09700 rnc GO:0010468 regulation of gene expression biological_process KEEP_AS_NON_CORE genes/PSEPK/rnc/rnc-ai-review.yaml PTHR11207 PTN002257160 AN608 ok True PTN000129453 AN0 4 SPECIATION LUCA LUCA True True False 330 10 AGI_LocusCode:AT1G09700|ZFIN:ZDB-GENE-070209-23|UniProtKB:Q9NRR4|dictyBase:DDB_G0269426|CGD:CAL0000189883|PomBase:SPBC119.11c|dictyBase:DDB_G0268410|MGI:MGI:1261425|FB:FBgn0026722|WB:WBGene00009163 rnr GO:0006402 mRNA catabolic process biological_process ACCEPT genes/PSEPK/rnr/rnr-ai-review.yaml PTHR23355 PTN002360853 AN702 ok True PTN000599171 AN0 5 SPECIATION LUCA LUCA True True True 375 6 PomBase:SPAC2C4.07c|MGI:MGI:2442555|UniProtKB:Q8IYB7|SGD:S000005381|PomBase:SPBC26H8.10|UniProtKB:P21499 rpiA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/rpiA/rpiA-ai-review.yaml PTHR11934 PTN002277990 AN151 ok True PTN000232507 AN0 4 SPECIATION LUCA LUCA True True False 86 2 MGI:MGI:103254|UniProtKB:P0A7Z0 rpiA GO:0006014 D-ribose metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/rpiA/rpiA-ai-review.yaml PTHR11934 PTN002277990 AN151 ok True PTN000232507 AN0 4 SPECIATION LUCA LUCA True True False 86 1 UniProtKB:P0A7Z0 rsmG GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/rsmG/rsmG-ai-review.yaml PTHR31760 PTN002421867 AN144 ok True PTN000788684 AN0 4 SPECIATION LUCA LUCA True True False 86 1 UniProtKB:P0A6U5 scpC GO:0003986 acetyl-CoA hydrolase activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/scpC/scpC-ai-review.yaml PTHR43609 PTN002462025 AN45 ok True PTN000484586 AN0 5 SPECIATION LUCA LUCA True True False 26 2 CGD:CAL0000189008|SGD:S000000111 sdhA GO:0000104 succinate dehydrogenase activity molecular_function ACCEPT genes/PSEPK/sdhA/sdhA-ai-review.yaml PTHR11632 PTN002267550 AN359 no_same_term_ibd_on_path False sdhA GO:0009061 anaerobic respiration biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/sdhA/sdhA-ai-review.yaml PTHR11632 PTN002267550 AN359 ok True PTN000180228 AN14 5 DUPLICATION LUCA True False True 194 1 UniProtKB:P00363 sdhB GO:0009060 aerobic respiration biological_process ACCEPT genes/PSEPK/sdhB/sdhB-ai-review.yaml PTHR11921 PTN002277013 AN404 ok True PTN000229864 AN0 6 SPECIATION LUCA LUCA True True True 224 5 FB:FBgn0014028|MGI:MGI:1914930|ZFIN:ZDB-GENE-030131-8005|SGD:S000003964|UniProtKB:P07014 sdhB GO:0022904 respiratory electron transport chain biological_process ACCEPT genes/PSEPK/sdhB/sdhB-ai-review.yaml PTHR11921 PTN002277013 AN404 ok True PTN000229864 AN0 6 SPECIATION LUCA LUCA True True True 224 4 RGD:1308598|FB:FBgn0014028|ZFIN:ZDB-GENE-030131-8005|SGD:S000003964 sdhD GO:0009055 electron transfer activity molecular_function ACCEPT genes/PSEPK/sdhD/sdhD-ai-review.yaml PTHR38689 PTN002446067 AN8 ok True PTN002446065 AN0 3 SPECIATION Eubacteria Eubacteria True True False 9 1 UniProtKB:P0AC44 sdhD GO:0009060 aerobic respiration biological_process ACCEPT genes/PSEPK/sdhD/sdhD-ai-review.yaml PTHR38689 PTN002446067 AN8 ok True PTN002446065 AN0 3 SPECIATION Eubacteria Eubacteria True True False 9 1 UniProtKB:P0AC44 sdhD GO:0017004 cytochrome complex assembly biological_process MARK_AS_OVER_ANNOTATED genes/PSEPK/sdhD/sdhD-ai-review.yaml PTHR38689 PTN002446067 AN8 ok True PTN002446065 AN0 3 SPECIATION Eubacteria Eubacteria True True False 9 1 UniProtKB:P0AC44 secA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/secA/secA-ai-review.yaml PTHR30612 PTN002413038 AN283 no_same_term_ibd_on_path False secD GO:0015031 protein transport biological_process KEEP_AS_NON_CORE genes/PSEPK/secD/secD-ai-review.yaml PTHR30081 PTN002409401 AN106 ok True PTN000763987 AN0 6 DUPLICATION True True 77 2 UniProtKB:P0AG90|UniProtKB:P0AG93 secF GO:0015031 protein transport biological_process KEEP_AS_NON_CORE genes/PSEPK/secF/secF-ai-review.yaml PTHR30081 PTN002409392 AN59 ok True PTN000763987 AN0 5 DUPLICATION True True 77 2 UniProtKB:P0AG90|UniProtKB:P0AG93 secG GO:0043952 protein transport by the Sec complex biological_process ACCEPT genes/PSEPK/secG/secG-ai-review.yaml PTHR34182 PTN002437140 AN25 ok True PTN002149719 AN0 3 SPECIATION Eubacteria Eubacteria True True False 23 1 UniProtKB:P0AG99 secG GO:0065002 intracellular protein transmembrane transport biological_process ACCEPT genes/PSEPK/secG/secG-ai-review.yaml PTHR34182 PTN002437140 AN25 ok True PTN002149719 AN0 3 SPECIATION Eubacteria Eubacteria True True False 23 1 UniProtKB:P0AG99 selB GO:0006414 translational elongation biological_process MODIFY genes/PSEPK/selB/selB-ai-review.yaml PTHR43721 PTN000562234 AN91 ok True PTN001500717 AN0 2 SPECIATION LUCA LUCA True True True 421 9 PomBase:SPBC9B6.04c|UniProtKB:P49411|MGI:MGI:2137092|FB:FBgn0034627|UniProtKB:P49410|MGI:MGI:1860138|SGD:S000005713|UniProtKB:P57772|WB:WBGene00008133 selD GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/selD/selD-ai-review.yaml PTHR10256 PTN002231424 AN149 ok True PTN000029003 AN0 5 SPECIATION LUCA LUCA True True False 80 4 MGI:MGI:108388|UniProtKB:Q99611|UniProtKB:P16456|UniProtKB:P49903 serB GO:0000287 magnesium ion binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/serB/serB-ai-review.yaml PTHR43344 PTN002458362 AN326 ok True PTN000000002 AN35 6 SPECIATION LUCA LUCA True False True 160 3 UniProtKB:P78330|UniProtKB:Q9I2Y2|UniProtKB:P0AGB0 serB GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/serB/serB-ai-review.yaml PTHR43344 PTN002458362 AN326 ok True PTN000000002 AN35 6 SPECIATION LUCA LUCA True False True 160 4 UniProtKB:P78330|AGI_LocusCode:AT1G18640|UniProtKB:P0AGB0|MGI:MGI:97788 speC GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/speC/speC-ai-review.yaml PTHR11482 PTN001691019 AN462 ok True PTN000159726 AN0 4 SPECIATION LUCA LUCA True True False 261 6 RGD:1564776|MGI:MGI:2442093|UniProtKB:Q96A70|MGI:MGI:97402|dictyBase:DDB_G0281109|RGD:3227 ssb GO:0009295 nucleoid cellular_component ACCEPT genes/PSEPK/ssb/ssb-ai-review.yaml PTHR10302 PTN000816303 AN629 ok True PTN000033807 AN0 5 SPECIATION LUCA LUCA True True True 347 4 SGD:S000007222|FB:FBgn0010438|UniProtKB:Q04837|UniProtKB:P0AGE0 ssuD GO:0046306 alkanesulfonate catabolic process biological_process ACCEPT genes/PSEPK/ssuD/ssuD-ai-review.yaml PTHR42847 PTN002450490 AN47 ok True PTN000768559 AN10 5 SPECIATION Eubacteria Eubacteria True False True 24 1 UniProtKB:P80645 sucA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/sucA/sucA-ai-review.yaml PTHR23152 PTN002351796 AN468 ok True PTN000568360 AN74 3 SPECIATION Eubacteria Eubacteria True False False 215 1 UniProtKB:P0AFG3 sucA GO:0006099 tricarboxylic acid cycle biological_process ACCEPT genes/PSEPK/sucA/sucA-ai-review.yaml PTHR23152 PTN002351796 AN468 ok True PTN000568360 AN74 3 SPECIATION Eubacteria Eubacteria True False False 215 5 UniProtKB:P9WIS5|UniProtKB:P0AFG3|MGI:MGI:1098267|RGD:1310916|FB:FBgn0010352 sucA GO:0045252 oxoglutarate dehydrogenase complex cellular_component ACCEPT genes/PSEPK/sucA/sucA-ai-review.yaml PTHR23152 PTN002351796 AN468 ok True PTN000568360 AN74 3 SPECIATION Eubacteria Eubacteria True False False 215 5 MGI:MGI:1098267|SGD:S000001387|RGD:1561359|UniProtKB:P0AFG3|UniProtKB:Q02218 sucB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/sucB/sucB-ai-review.yaml PTHR43416 PTN002459369 AN558 ok True PTN002459361 AN510 4 DUPLICATION LUCA True False True 34 1 UniProtKB:P0AFG6 sucC GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/sucC/sucC-ai-review.yaml PTHR11815 PTN002273944 AN384 ok True PTN000212645 AN351 3 SPECIATION Eubacteria Eubacteria True False False 26 1 UniProtKB:P0A836 sucC GO:0006104 succinyl-CoA metabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/sucC/sucC-ai-review.yaml PTHR11815 PTN002273944 AN384 ok True PTN000212531 AN0 4 SPECIATION LUCA LUCA True True False 208 4 RGD:1309397|RGD:1305008|UniProtKB:Q84LB6|SGD:S000003476 sucD GO:0009361 succinate-CoA ligase complex (ADP-forming) cellular_component ACCEPT genes/PSEPK/sucD/sucD-ai-review.yaml PTHR11117 PTN002254993 AN337 ok True PTN000122012 AN1 6 SPECIATION LUCA LUCA True False False 187 1 UniProtKB:P0AGE9 tal GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/tal/tal-ai-review.yaml PTHR10683 PTN002242200 AN429 ok True PTN001321958 AN422 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 11 2 UniProtKB:P0A867|UniProtKB:P0A870 tatC-I GO:0009977 proton motive force dependent protein transmembrane transporter activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/tatC-I/tatC-I-ai-review.yaml PTHR30371 PTN002411347 AN224 ok True PTN000769484 AN0 4 SPECIATION LUCA LUCA True True False 129 1 UniProtKB:P69423 tatC-I GO:0065002 intracellular protein transmembrane transport biological_process ACCEPT genes/PSEPK/tatC-I/tatC-I-ai-review.yaml PTHR30371 PTN002411347 AN224 ok True PTN000769484 AN0 4 SPECIATION LUCA LUCA True True False 129 1 UniProtKB:P69423 tatC-II GO:0009977 proton motive force dependent protein transmembrane transporter activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/tatC-II/tatC-II-ai-review.yaml PTHR30371 PTN002411347 AN224 ok True PTN000769484 AN0 4 SPECIATION LUCA LUCA True True False 129 1 UniProtKB:P69423 tatC-II GO:0065002 intracellular protein transmembrane transport biological_process ACCEPT genes/PSEPK/tatC-II/tatC-II-ai-review.yaml PTHR30371 PTN002411347 AN224 ok True PTN000769484 AN0 4 SPECIATION LUCA LUCA True True False 129 1 UniProtKB:P69423 tauA GO:0042918 alkanesulfonate transmembrane transport biological_process MODIFY genes/PSEPK/tauA/tauA-ai-review.yaml PTHR30024 PTN001246836 AN164 no_same_term_ibd_on_path False tauC GO:0010438 cellular response to sulfur starvation biological_process UNDECIDED genes/PSEPK/tauC/tauC-ai-review.yaml PTHR30151 PTN002014157 AN68 ok True PTN000765473 AN61 3 SPECIATION Proteobacteria Proteobacteria True False True 6 1 UniProtKB:Q47539 tauD GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/tauD/tauD-ai-review.yaml PTHR30468 PTN002411909 AN124 ok True PTN000765899 AN0 6 SPECIATION LUCA LUCA True True True 70 1 UniProtKB:P37610 tauD GO:0006790 sulfur compound metabolic process biological_process MODIFY genes/PSEPK/tauD/tauD-ai-review.yaml PTHR30468 PTN002411909 AN124 ok True PTN000765929 AN116 4 SPECIATION Eubacteria Eubacteria True False True 7 1 UniProtKB:P37610 tgt GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/tgt/tgt-ai-review.yaml PTHR46499 PTN002326788 AN61 ok True PTN000239043 AN0 4 SPECIATION LUCA LUCA True True False 44 2 UniProtKB:Q8I507|UniProtKB:P0A847 tgt GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/tgt/tgt-ai-review.yaml PTHR46499 PTN002326788 AN61 ok True PTN000239159 AN27 3 SPECIATION Eubacteria Eubacteria True False False 28 1 UniProtKB:P0A847 thiI GO:0002937 tRNA 4-thiouridine biosynthesis biological_process ACCEPT genes/PSEPK/thiI/thiI-ai-review.yaml PTHR43209 PTN002456216 AN36 ok True PTN001804941 AN0 3 SPECIATION LUCA LUCA True True False 25 1 UniProtKB:P77718 thiI GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/thiI/thiI-ai-review.yaml PTHR43209 PTN002456216 AN36 no_same_term_ibd_on_path False thiO GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/thiO/thiO-ai-review.yaml PTHR13847 PTN002302707 AN324 ok True PTN000354057 AN0 8 DUPLICATION True True 460 10 RGD:621125|FB:FBgn0002021|UniProtKB:Q9UI17|UniProtKB:O46504|UniProtKB:P33940|UniProtKB:Q5JFG7|UniProtKB:Q96CU9|MGI:MGI:2183102|UniProtKB:Q38A60|SGD:S000001051 thrS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/thrS/thrS-ai-review.yaml PTHR11451 PTN002262613 AN535 ok True PTN000155230 AN524 2 SPECIATION Proteobacteria Proteobacteria True False False 13 1 UniProtKB:P0A8M3 tig GO:0043022 ribosome binding molecular_function ACCEPT genes/PSEPK/tig/tig-ai-review.yaml PTHR30560 PTN002412671 AN297 ok True PTN001254607 AN0 4 SPECIATION LUCA LUCA True True False 165 1 UniProtKB:P0A850 tig GO:0043335 protein unfolding biological_process KEEP_AS_NON_CORE genes/PSEPK/tig/tig-ai-review.yaml PTHR30560 PTN002412671 AN297 ok True PTN001254607 AN0 4 SPECIATION LUCA LUCA True True False 165 1 UniProtKB:P0A850 tig GO:0044183 protein folding chaperone molecular_function ACCEPT genes/PSEPK/tig/tig-ai-review.yaml PTHR30560 PTN002412671 AN297 ok True PTN001254607 AN0 4 SPECIATION LUCA LUCA True True False 165 1 UniProtKB:P0A850 tig GO:0051083 'de novo' cotranslational protein folding biological_process ACCEPT genes/PSEPK/tig/tig-ai-review.yaml PTHR30560 PTN002412671 AN297 ok True PTN001254607 AN0 4 SPECIATION LUCA LUCA True True False 165 1 UniProtKB:P0A850 tktA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/tktA/tktA-ai-review.yaml PTHR43522 PTN002460846 AN341 ok True PTN000179149 AN0 5 SPECIATION LUCA LUCA True True False 190 4 UniProtKB:Q4QAC4|dictyBase:DDB_G0272618|UniProtKB:P33570|UniProtKB:P27302 tktA GO:0006098 pentose-phosphate shunt biological_process KEEP_AS_NON_CORE genes/PSEPK/tktA/tktA-ai-review.yaml PTHR43522 PTN002460846 AN341 ok True PTN000179149 AN0 5 SPECIATION LUCA LUCA True True False 190 6 SGD:S000006278|UniProtKB:P33570|PomBase:SPBC2G5.05|UniProtKB:Q4QAC4|UniProtKB:P27302|SGD:S000000321 tolC GO:0015288 porin activity molecular_function MARK_AS_OVER_ANNOTATED genes/PSEPK/tolC/tolC-ai-review.yaml PTHR30026 PTN002011548 AN76 ok True PTN002011530 AN0 5 SPECIATION LUCA LUCA True True True 75 1 UniProtKB:P02930 tolC GO:1990281 efflux pump complex cellular_component MODIFY genes/PSEPK/tolC/tolC-ai-review.yaml PTHR30026 PTN002011548 AN76 ok True PTN002011530 AN0 5 SPECIATION LUCA LUCA True True True 75 2 UniProtKB:P02930|UniProtKB:Q8ZLZ4 tpiA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/tpiA/tpiA-ai-review.yaml PTHR21139 PTN002326603 AN572 ok True PTN000474644 AN525 3 SPECIATION Eubacteria Eubacteria True False False 36 1 UniProtKB:P0A858 tpiA GO:0019563 glycerol catabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/tpiA/tpiA-ai-review.yaml PTHR21139 PTN002326603 AN572 no_same_term_ibd_on_path False tpiA GO:0046166 glyceraldehyde-3-phosphate biosynthetic process biological_process KEEP_AS_NON_CORE genes/PSEPK/tpiA/tpiA-ai-review.yaml PTHR21139 PTN002326603 AN572 ok True PTN000474559 AN0 4 SPECIATION LUCA LUCA True True False 323 2 UniProtKB:P60174|AGI_LocusCode:AT2G21170 treY GO:0005992 trehalose biosynthetic process biological_process ACCEPT genes/PSEPK/treY/treY-ai-review.yaml PTHR10357 PTN002449569 AN114 ok True PTN008498486 AN100 4 SPECIATION LUCA LUCA True False False 10 1 UniProtKB:P9WQ21 treY GO:0030980 alpha-glucan catabolic process biological_process KEEP_AS_NON_CORE genes/PSEPK/treY/treY-ai-review.yaml PTHR10357 PTN002449569 AN114 ok True PTN008498486 AN100 4 SPECIATION LUCA LUCA True False False 10 1 UniProtKB:P9WQ21 trmB GO:0030488 tRNA methylation biological_process ACCEPT genes/PSEPK/trmB/trmB-ai-review.yaml PTHR23417 PTN002361431 AN387 ok True PTN000602515 AN0 4 SPECIATION LUCA LUCA True True False 210 5 UniProtKB:P0A8I5|UniProtKB:Q9UBP6|SGD:S000002360|FB:FBgn0025629|PomBase:SPCPB16A4.04c trmB GO:0036265 RNA (guanine-N7)-methylation biological_process KEEP_AS_NON_CORE genes/PSEPK/trmB/trmB-ai-review.yaml PTHR23417 PTN002361431 AN387 ok True PTN000602515 AN0 4 SPECIATION LUCA LUCA True True False 210 4 UniProtKB:P0A8I5|SGD:S000002360|UniProtKB:Q9UBP6|PomBase:SPCPB16A4.04c trmB GO:0043527 tRNA methyltransferase complex cellular_component MARK_AS_OVER_ANNOTATED genes/PSEPK/trmB/trmB-ai-review.yaml PTHR23417 PTN002361431 AN387 ok True PTN000602515 AN0 4 SPECIATION LUCA LUCA True True False 210 3 UniProtKB:Q9UBP6|SGD:S000002360|FB:FBgn0025629 trpA GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/trpA/trpA-ai-review.yaml PTHR43406 PTN002459213 AN253 ok True PTN000034360 AN0 4 SPECIATION LUCA LUCA True True False 151 1 UniProtKB:P0A877 trpB GO:0005737 cytoplasm cellular_component ACCEPT genes/PSEPK/trpB/trpB-ai-review.yaml PTHR48077 PTN002451019 AN298 ok True PTN000034394 AN1 4 SPECIATION LUCA LUCA True False False 169 2 AGI_LocusCode:AT4G27070|UniProtKB:P0A879 trpC GO:0004640 phosphoribosylanthranilate isomerase activity molecular_function REMOVE genes/PSEPK/trpC/trpC-ai-review.yaml PTHR22854 PTN002338157 AN231 no_same_term_ibd_on_path False trpD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/trpD/trpD-ai-review.yaml PTHR43285 PTN002457270 AN216 ok True PTN000230153 AN0 4 SPECIATION LUCA LUCA True True False 124 1 UniProtKB:P30177 trpS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/trpS/trpS-ai-review.yaml PTHR43766 PTN002464860 AN235 ok True PTN008684975 AN203 3 SPECIATION Eubacteria Eubacteria True False False 25 1 UniProtKB:P00954 ttgA GO:0046677 response to antibiotic biological_process KEEP_AS_NON_CORE genes/PSEPK/ttgA/ttgA-ai-review.yaml PTHR30158 PTN002410003 AN16 ok True PTN001249140 AN0 4 DUPLICATION True True 38 6 UniProtKB:P37636|UniProtKB:G3XD21|UniProtKB:P0AE06|UniProtKB:P52477|UniProtKB:Q9I0Y9|UniProtKB:G3XD25 ttgB GO:0042910 xenobiotic transmembrane transporter activity molecular_function ACCEPT genes/PSEPK/ttgB/ttgB-ai-review.yaml PTHR32063 PTN002424656 AN27 ok True PTN004918764 AN0 6 HORIZONTAL_TRANSFER True True 183 2 UniProtKB:P31224|UniProtKB:P37637 ttgR GO:0000976 transcription cis-regulatory region binding molecular_function ACCEPT genes/PSEPK/ttgR/ttgR-ai-review.yaml PTHR30055 PTN004738680 AN291 ok True PTN004738546 AN22 7 SPECIATION LUCA LUCA False True 411 7 UniProtKB:P0ACS9|UniProtKB:P32265|UniProtKB:Q9HXW2|UniProtKB:Q9HXS0|UniProtKB:Q9KR96|UniProtKB:G3XCU9|UniProtKB:Q9HY46 tusD GO:0002143 tRNA wobble position uridine thiolation biological_process ACCEPT genes/PSEPK/tusD/tusD-ai-review.yaml PTHR34874 PTN002439462 AN14 ok True PTN002166909 AN10 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P45532 tusD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/tusD/tusD-ai-review.yaml PTHR34874 PTN002439462 AN14 ok True PTN002166889 AN0 4 SPECIATION LUCA LUCA True True True 16 2 UniProtKB:P45532|UniProtKB:P0AB52 tusD GO:0097163 sulfur carrier activity molecular_function ACCEPT genes/PSEPK/tusD/tusD-ai-review.yaml PTHR34874 PTN002439462 AN14 ok True PTN002166909 AN10 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P45532 tusD GO:1990228 sulfurtransferase complex cellular_component ACCEPT genes/PSEPK/tusD/tusD-ai-review.yaml PTHR34874 PTN002439462 AN14 ok True PTN002166909 AN10 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P45532 tusE GO:0002143 tRNA wobble position uridine thiolation biological_process ACCEPT genes/PSEPK/tusE/tusE-ai-review.yaml PTHR37010 PTN002443910 AN10 ok True PTN002200704 AN0 3 SPECIATION LUCA LUCA True True False 10 1 UniProtKB:P0AB18 tusE GO:0097163 sulfur carrier activity molecular_function ACCEPT genes/PSEPK/tusE/tusE-ai-review.yaml PTHR37010 PTN002443910 AN10 ok True PTN002200704 AN0 3 SPECIATION LUCA LUCA True True False 10 1 UniProtKB:P0AB18 tyrB GO:0004838 L-tyrosine:2-oxoglutarate transaminase activity molecular_function ACCEPT genes/PSEPK/tyrB/tyrB-ai-review.yaml PTHR11879 PTN002275473 AN758 ok True PTN000222931 AN753 3 DUPLICATION Eubacteria True False True 16 2 UniProtKB:P00509|UniProtKB:P04693 tyrB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/tyrB/tyrB-ai-review.yaml PTHR11879 PTN002275473 AN758 ok True PTN000222931 AN753 3 DUPLICATION Eubacteria True False True 16 1 UniProtKB:P04693 tyrB GO:0042802 identical protein binding molecular_function KEEP_AS_NON_CORE genes/PSEPK/tyrB/tyrB-ai-review.yaml PTHR11879 PTN002275473 AN758 ok True PTN000222929 AN748 4 SPECIATION Eubacteria Eubacteria True False True 19 2 UniProtKB:P00509|UniProtKB:P04693 tyrS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/tyrS/tyrS-ai-review.yaml PTHR11766 PTN002272564 AN236 ok True PTN000205473 AN213 4 DUPLICATION LUCA True False True 39 1 UniProtKB:P0AGJ9 tyrS GO:0043039 tRNA aminoacylation biological_process KEEP_AS_NON_CORE genes/PSEPK/tyrS/tyrS-ai-review.yaml PTHR11766 PTN002272564 AN236 ok True PTN000205414 AN0 5 SPECIATION LUCA LUCA True True True 147 3 UniProtKB:Q9Y2Z4|SGD:S000006018|UniProtKB:P0AGJ9 ubiA GO:0016740 transferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/ubiA/ubiA-ai-review.yaml PTHR11048 PTN004223178 AN293 ok True PTN000114159 AN0 5 SPECIATION LUCA LUCA True True True 164 7 AGI_LocusCode:AT4G23660|UniProtKB:P0AGK1|MGI:MGI:1919133|PomBase:SPAC56F8.04c|UniProtKB:Q96H96|SGD:S000005324|UniProtKB:P9WFR5 ubiC GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ubiC/ubiC-ai-review.yaml PTHR38683 PTN002446048 AN4 ok True PTN002214686 AN0 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True True False 7 1 UniProtKB:P26602 ubiD GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/PSEPK/ubiD/ubiD-ai-review.yaml PTHR30108 PTN002409573 AN53 ok True PTN000764648 AN0 6 SPECIATION LUCA LUCA True True True 38 1 UniProtKB:P0AAB4 ubiD GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ubiD/ubiD-ai-review.yaml PTHR30108 PTN002409573 AN53 ok True PTN000764659 AN31 4 SPECIATION Eubacteria Eubacteria True False True 20 1 UniProtKB:P0AAB4 ubiG GO:0008168 methyltransferase activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/ubiG/ubiG-ai-review.yaml PTHR43464 PTN002460086 AN30 ok True PTN002459972 AN0 7 DUPLICATION True True 461 10 FB:FBgn0028841|SGD:S000005456|WB:WBGene00000763|UniProtKB:P25397|UniProtKB:P12999|UniProtKB:P9WLL9|AGI_LocusCode:AT2G30920|UniProtKB:Q9NZJ6|UniProtKB:P17993|UniProtKB:P36566 ubiK GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/ubiK/ubiK-ai-review.yaml PTHR38040 PTN002445503 AN7 ok True PTN002211000 AN2 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 8 1 UniProtKB:Q46868 ubiX GO:0016831 carboxy-lyase activity molecular_function REMOVE genes/PSEPK/ubiX/ubiX-ai-review.yaml PTHR43374 PTN002458738 AN62 no_same_term_ibd_on_path False uppS GO:0005829 cytosol cellular_component UNDECIDED genes/PSEPK/uppS/uppS-ai-review.yaml PTHR10291 PTN002232315 AN660 ok True PTN000033434 AN647 2 SPECIATION Proteobacteria Proteobacteria True False False 14 1 UniProtKB:P60472 uppS GO:0016094 polyprenol biosynthetic process biological_process ACCEPT genes/PSEPK/uppS/uppS-ai-review.yaml PTHR10291 PTN002232315 AN660 ok True PTN000033324 AN0 5 SPECIATION LUCA LUCA True True True 380 3 UniProtKB:P9WFF5|UniProtKB:P9WFF7|UniProtKB:P60472 uppS GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity molecular_function KEEP_AS_NON_CORE genes/PSEPK/uppS/uppS-ai-review.yaml PTHR10291 PTN002232315 AN660 ok True PTN000033324 AN0 5 SPECIATION LUCA LUCA True True True 380 4 UniProtKB:Q86SQ9|SGD:S000004707|SGD:S000000206|PomBase:SPAC4D7.04c uvrD GO:0000725 recombinational repair biological_process KEEP_AS_NON_CORE genes/PSEPK/uvrD/uvrD-ai-review.yaml PTHR11070 PTN008511651 AN412 ok True PTN000116141 AN1 7 SPECIATION LUCA LUCA True False True 245 5 UniProtKB:F1ND48|SGD:S000003628|PomBase:SPBC336.01|PomBase:SPAC4H3.05|UniProtKB:P08394 uvrD GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/uvrD/uvrD-ai-review.yaml PTHR11070 PTN008511651 AN412 ok True PTN000869814 AN230 5 DUPLICATION LUCA True False True 124 2 UniProtKB:P03018|UniProtKB:P15038 uvrD GO:0033202 DNA helicase complex cellular_component KEEP_AS_NON_CORE genes/PSEPK/uvrD/uvrD-ai-review.yaml PTHR11070 PTN008511651 AN412 ok True PTN000116196 AN307 4 SPECIATION Eubacteria Eubacteria True False True 70 2 UniProtKB:P03018|UniProtKB:P9WMQ1 vacJ GO:0120010 intermembrane phospholipid transfer biological_process ACCEPT genes/PSEPK/vacJ/vacJ-ai-review.yaml PTHR30035 PTN002409000 AN17 ok True PTN001247191 AN6 4 SPECIATION Eubacteria Eubacteria True False True 12 1 UniProtKB:P76506 valS GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/valS/valS-ai-review.yaml PTHR11946 PTN002278760 AN482 ok True PTN000236191 AN443 3 SPECIATION Eubacteria Eubacteria True False False 32 1 UniProtKB:P07118 visC GO:0019168 2-polyprenylphenol 6-hydroxylase activity molecular_function ACCEPT genes/PSEPK/visC/visC-ai-review.yaml PTHR43876 PTN002466904 AN355 ok True PTN000350245 AN351 1 SPECIATION Gammaproteobacteria Gammaproteobacteria True False False 7 1 UniProtKB:P25535 xseB GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/xseB/xseB-ai-review.yaml PTHR34137 PTN002437006 AN35 ok True PTN002148936 AN0 3 SPECIATION Eubacteria Eubacteria True True False 27 1 UniProtKB:P0A8G9 ydiJ GO:0004458 D-lactate dehydrogenase (cytochrome) activity molecular_function MODIFY genes/PSEPK/ydiJ/ydiJ-ai-review.yaml PTHR11748 PTN001714929 AN276 ok True PTN000202298 AN1 4 SPECIATION LUCA LUCA True False True 153 2 AGI_LocusCode:AT5G06580|SGD:S000002333 ydiJ GO:0008720 D-lactate dehydrogenase (NAD+) activity molecular_function MODIFY genes/PSEPK/ydiJ/ydiJ-ai-review.yaml PTHR11748 PTN001714929 AN276 ok True PTN000202298 AN1 4 SPECIATION LUCA LUCA True False True 153 1 AGI_LocusCode:AT5G06580 ydiJ GO:1903457 lactate catabolic process biological_process MODIFY genes/PSEPK/ydiJ/ydiJ-ai-review.yaml PTHR11748 PTN001714929 AN276 ok True PTN000202298 AN1 4 SPECIATION LUCA LUCA True False True 153 3 UniProtKB:Q86WU2|ZFIN:ZDB-GENE-030131-6140|SGD:S000002333 zwf GO:0005829 cytosol cellular_component ACCEPT genes/PSEPK/zwf/zwf-ai-review.yaml PTHR23429 PTN002765778 AN678 ok True PTN000604542 AN638 4 SPECIATION Eubacteria Eubacteria True False True 31 1 UniProtKB:P0AC53 zwf GO:0009051 pentose-phosphate shunt, oxidative branch biological_process KEEP_AS_NON_CORE genes/PSEPK/zwf/zwf-ai-review.yaml PTHR23429 PTN002765778 AN678 ok True PTN000604427 AN0 5 SPECIATION LUCA LUCA True True True 363 11 AGI_LocusCode:AT3G27300|FB:FBgn0004057|UniProtKB:P11413|AGI_LocusCode:AT1G24280|AGI_LocusCode:AT5G35790|SGD:S000005185|MGI:MGI:105979|AGI_LocusCode:AT5G40760|RGD:2645|UniProtKB:O95479|AGI_LocusCode:AT5G13110 zwfA GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/zwfA/zwfA-ai-review.yaml PTHR23429 PTN002361873 AN679 ok True PTN000604542 AN638 4 SPECIATION Eubacteria Eubacteria True False True 31 1 UniProtKB:P0AC53 zwfA GO:0009051 pentose-phosphate shunt, oxidative branch biological_process ACCEPT genes/PSEPK/zwfA/zwfA-ai-review.yaml PTHR23429 PTN002361873 AN679 ok True PTN000604427 AN0 5 SPECIATION LUCA LUCA True True True 363 11 AGI_LocusCode:AT3G27300|FB:FBgn0004057|UniProtKB:P11413|AGI_LocusCode:AT1G24280|AGI_LocusCode:AT5G35790|SGD:S000005185|MGI:MGI:105979|AGI_LocusCode:AT5G40760|RGD:2645|UniProtKB:O95479|AGI_LocusCode:AT5G13110 zwfB GO:0005829 cytosol cellular_component KEEP_AS_NON_CORE genes/PSEPK/zwfB/zwfB-ai-review.yaml PTHR23429 PTN000604558 AN669 ok True PTN000604542 AN638 2 SPECIATION Eubacteria Eubacteria True False False 31 1 UniProtKB:P0AC53 zwfB GO:0009051 pentose-phosphate shunt, oxidative branch biological_process ACCEPT genes/PSEPK/zwfB/zwfB-ai-review.yaml PTHR23429 PTN000604558 AN669 ok True PTN000604427 AN0 3 SPECIATION LUCA LUCA True True False 363 11 AGI_LocusCode:AT3G27300|FB:FBgn0004057|UniProtKB:P11413|AGI_LocusCode:AT1G24280|AGI_LocusCode:AT5G35790|SGD:S000005185|MGI:MGI:105979|AGI_LocusCode:AT5G40760|RGD:2645|UniProtKB:O95479|AGI_LocusCode:AT5G13110 PoMZ_10221 GO:0006556 S-adenosylmethionine biosynthetic process biological_process UNDECIDED genes/PYROR/PoMZ_10221/PoMZ_10221-ai-review.yaml PTHR10491 PTN008946252 AN75 ok True PTN000051875 AN1 3 SPECIATION Eukaryota Eukaryota True False False 46 1 UniProtKB:Q9NZL9 PoMZ_10221 GO:0048269 methionine adenosyltransferase complex cellular_component UNDECIDED genes/PYROR/PoMZ_10221/PoMZ_10221-ai-review.yaml PTHR10491 PTN008946252 AN75 ok True PTN000051875 AN1 3 SPECIATION Eukaryota Eukaryota True False False 46 1 UniProtKB:Q9NZL9 PoMZ_10221 GO:0048270 methionine adenosyltransferase regulator activity molecular_function UNDECIDED genes/PYROR/PoMZ_10221/PoMZ_10221-ai-review.yaml PTHR10491 PTN008946252 AN75 no_same_term_ibd_on_path False RvY_01767 GO:0030145 manganese ion binding molecular_function ACCEPT genes/RAMVA/RvY_01767/RvY_01767-ai-review.yaml PTHR11404 PTN000891835 AN82 ok True PTN004256454 AN7 10 HORIZONTAL_TRANSFER Archaea-Eukaryota True False False 155 4 PomBase:SPAC1486.01|UniProtKB:Q92450|UniProtKB:P04179|RGD:3732 nirK2 GO:0016491 oxidoreductase activity molecular_function KEEP_AS_NON_CORE genes/RHOPA/nirK2/nirK2-ai-review.yaml PTHR11709 PTN008524827 AN4203 ok True PTN000194698 AN1 4 DUPLICATION False True 2401 25 UniProtKB:E9RBR0|FB:FBgn0052557|CGD:CAL0000183587|UniProtKB:P07788|SGD:S000004662|MGI:MGI:88476|AGI_LocusCode:AT5G60020|FB:FBgn0039387|UniProtKB:Q5B233|AGI_LocusCode:AT5G21100|AGI_LocusCode:AT2G38080|UniProtKB:Q6MZM0|AGI_LocusCode:AT1G23010|UniProtKB:P17489|UniProtKB:Q9BQS7|MGI:MGI:1332240|FB:FBgn0032116|PomBase:SPAC1F7.08|UniProtKB:Q5ARB0|AGI_LocusCode:AT1G71040|UniProtKB:Q5BEX9|UniProtKB:Q5BF02|SGD:S000001853|UniProtKB:P36649|UniProtKB:P00450 A4F7P6 GO:0008610 lipid biosynthetic process biological_process MODIFY genes/SACEN/A4F7P6/A4F7P6-ai-review.yaml PTHR11487 PTN000160696 AN53 ok True PTN000160660 AN0 6 SPECIATION LUCA LUCA True True True 40 3 UniProtKB:Q9NV23|RGD:621115|UniProtKB:P9WQD5 ermE GO:0005829 cytosol cellular_component ACCEPT genes/SACEN/ermE/ermE-ai-review.yaml PTHR11727 PTN000197986 AN600 ok True PTN000197981 AN594 5 SPECIATION Eubacteria Eubacteria True False True 37 1 UniProtKB:P06992 ermE GO:0031167 rRNA methylation biological_process ACCEPT genes/SACEN/ermE/ermE-ai-review.yaml PTHR11727 PTN000197986 AN600 ok True PTN000197843 AN0 7 SPECIATION LUCA LUCA True True True 341 4 UniProtKB:Q8WVM0|MGI:MGI:2146851|UniProtKB:P06992|UniProtKB:Q9UNQ2 eryAI GO:0004312 fatty acid synthase activity molecular_function MODIFY genes/SACEN/eryAI/eryAI-ai-review.yaml PTHR43775 PTN000918870 AN291 ok True PTN000196555 AN0 3 SPECIATION LUCA LUCA True True True 200 6 RGD:620665|FB:FBgn0042627|UniProtKB:P49327|FB:FBgn0283427|dictyBase:DDB_G0275077|MGI:MGI:95485 eryAII GO:0004312 fatty acid synthase activity molecular_function MODIFY genes/SACEN/eryAII/eryAII-ai-review.yaml PTHR43775 PTN000918870 AN291 ok True PTN000196555 AN0 3 SPECIATION LUCA LUCA True True True 200 6 RGD:620665|FB:FBgn0042627|UniProtKB:P49327|FB:FBgn0283427|dictyBase:DDB_G0275077|MGI:MGI:95485 eryAIII GO:0004312 fatty acid synthase activity molecular_function MODIFY genes/SACEN/eryAIII/eryAIII-ai-review.yaml PTHR43775 PTN000918870 AN291 ok True PTN000196555 AN0 3 SPECIATION LUCA LUCA True True True 200 6 RGD:620665|FB:FBgn0042627|UniProtKB:P49327|FB:FBgn0283427|dictyBase:DDB_G0275077|MGI:MGI:95485 eryBVII GO:0000271 polysaccharide biosynthetic process biological_process MODIFY genes/SACEN/eryBVII/eryBVII-ai-review.yaml PTHR21047 PTN002325964 AN32 ok True PTN000471580 AN0 5 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 eryBVII GO:0005829 cytosol cellular_component ACCEPT genes/SACEN/eryBVII/eryBVII-ai-review.yaml PTHR21047 PTN002325964 AN32 ok True PTN000471580 AN0 5 SPECIATION LUCA LUCA True True False 38 1 UniProtKB:P37745 eryBVII GO:0016854 racemase and epimerase activity molecular_function ACCEPT genes/SACEN/eryBVII/eryBVII-ai-review.yaml PTHR21047 PTN002325964 AN32 ok True PTN000471580 AN0 5 SPECIATION LUCA LUCA True True False 38 3 UniProtKB:P9WH11|UniProtKB:Q9HU21|UniProtKB:P26394 eryBVII GO:0019305 dTDP-rhamnose biosynthetic process biological_process MODIFY genes/SACEN/eryBVII/eryBVII-ai-review.yaml PTHR21047 PTN002325964 AN32 ok True PTN000471594 AN24 4 SPECIATION Eubacteria Eubacteria True False False 25 2 UniProtKB:P9WH11|UniProtKB:Q9HU21 eryCI GO:0000271 polysaccharide biosynthetic process biological_process MODIFY genes/SACEN/eryCI/eryCI-ai-review.yaml PTHR30244 PTN002015832 AN53 ok True PTN001250039 AN0 5 SPECIATION LUCA LUCA True True True 98 2 UniProtKB:P27833|UniProtKB:Q9HZ76 eryCIV GO:0000271 polysaccharide biosynthetic process biological_process MODIFY genes/SACEN/eryCIV/eryCIV-ai-review.yaml PTHR30244 PTN000767067 AN103 ok True PTN001250039 AN0 4 SPECIATION LUCA LUCA True True True 98 2 UniProtKB:P27833|UniProtKB:Q9HZ76 eryCIV GO:0008483 transaminase activity molecular_function UNDECIDED genes/SACEN/eryCIV/eryCIV-ai-review.yaml PTHR30244 PTN000767067 AN103 ok True PTN001250039 AN0 4 SPECIATION LUCA LUCA True True True 98 6 UniProtKB:Q8ZNF3|UniProtKB:O07566|UniProtKB:P27833|UniProtKB:Q9HZ76|UniProtKB:P77690|UniProtKB:Q814Z4 eryCIV GO:0030170 pyridoxal phosphate binding molecular_function ACCEPT genes/SACEN/eryCIV/eryCIV-ai-review.yaml PTHR30244 PTN000767067 AN103 ok True PTN001250039 AN0 4 SPECIATION LUCA LUCA True True True 98 4 UniProtKB:P77690|UniProtKB:Q9HZ76|UniProtKB:P27833|UniProtKB:O07566 PTSG_05882 GO:0000902 cell morphogenesis biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 8 MGI:MGI:99218|UniProtKB:P10288|ZFIN:ZDB-GENE-980526-170|MGI:MGI:99217|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-040816-1|MGI:MGI:105057|MGI:MGI:88354 PTSG_05882 GO:0005912 adherens junction cellular_component REMOVE genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 10 MGI:MGI:105057|MGI:MGI:88356|MGI:MGI:88354|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|RGD:69280|UniProtKB:P33151|UniProtKB:P19022|MGI:MGI:88355|UniProtKB:P10288 PTSG_05882 GO:0007043 cell-cell junction assembly biological_process REMOVE genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 UniProtKB:P12830|MGI:MGI:88355|UniProtKB:P33151|MGI:MGI:88354 PTSG_05882 GO:0008013 beta-catenin binding molecular_function REMOVE genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 8 UniProtKB:P12830|UniProtKB:Q8IXH8|MGI:MGI:88354|RGD:69279|UniProtKB:P19022|UniProtKB:P33151|UniProtKB:Q86UP0|RGD:69280 PTSG_05882 GO:0016339 calcium-dependent cell-cell adhesion biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 6 MGI:MGI:88355|UniProtKB:P55290|RGD:2321|MGI:MGI:1095414|RGD:69280|MGI:MGI:88354 PTSG_05882 GO:0016342 catenin complex cellular_component REMOVE genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 5 MGI:MGI:88354|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-010606-1|UniProtKB:P19022|UniProtKB:P12830 PTSG_05882 GO:0016477 cell migration biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 10 UniProtKB:Q96JQ0|ZFIN:ZDB-GENE-990415-171|UniProtKB:Q90763|UniProtKB:P55290|MGI:MGI:2685011|UniProtKB:P33151|MGI:MGI:88355|MGI:MGI:105057|UniProtKB:F1RFU7|ZFIN:ZDB-GENE-010606-1 PTSG_05882 GO:0034332 adherens junction organization biological_process REMOVE genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 ZFIN:ZDB-GENE-990415-171|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|UniProtKB:P33151 PTSG_05882 GO:0044331 cell-cell adhesion mediated by cadherin biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 5 MGI:MGI:88354|MGI:MGI:88355|UniProtKB:P33151|UniProtKB:P10288|UniProtKB:P12830 PTSG_05882 GO:0045296 cadherin binding molecular_function MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_05882/PTSG_05882-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 3 UniProtKB:P10288|UniProtKB:P55290|MGI:MGI:107433 PTSG_06458 GO:0000902 cell morphogenesis biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 8 MGI:MGI:99218|UniProtKB:P10288|ZFIN:ZDB-GENE-980526-170|MGI:MGI:99217|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-040816-1|MGI:MGI:105057|MGI:MGI:88354 PTSG_06458 GO:0005912 adherens junction cellular_component REMOVE genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 10 MGI:MGI:105057|MGI:MGI:88356|MGI:MGI:88354|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|RGD:69280|UniProtKB:P33151|UniProtKB:P19022|MGI:MGI:88355|UniProtKB:P10288 PTSG_06458 GO:0007043 cell-cell junction assembly biological_process REMOVE genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 UniProtKB:P12830|MGI:MGI:88355|UniProtKB:P33151|MGI:MGI:88354 PTSG_06458 GO:0008013 beta-catenin binding molecular_function REMOVE genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 8 UniProtKB:P12830|UniProtKB:Q8IXH8|MGI:MGI:88354|RGD:69279|UniProtKB:P19022|UniProtKB:P33151|UniProtKB:Q86UP0|RGD:69280 PTSG_06458 GO:0016339 calcium-dependent cell-cell adhesion biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 6 MGI:MGI:88355|UniProtKB:P55290|RGD:2321|MGI:MGI:1095414|RGD:69280|MGI:MGI:88354 PTSG_06458 GO:0016342 catenin complex cellular_component REMOVE genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 5 MGI:MGI:88354|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-010606-1|UniProtKB:P19022|UniProtKB:P12830 PTSG_06458 GO:0016477 cell migration biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 10 UniProtKB:Q96JQ0|ZFIN:ZDB-GENE-990415-171|UniProtKB:Q90763|UniProtKB:P55290|MGI:MGI:2685011|UniProtKB:P33151|MGI:MGI:88355|MGI:MGI:105057|UniProtKB:F1RFU7|ZFIN:ZDB-GENE-010606-1 PTSG_06458 GO:0034332 adherens junction organization biological_process REMOVE genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 ZFIN:ZDB-GENE-990415-171|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|UniProtKB:P33151 PTSG_06458 GO:0044331 cell-cell adhesion mediated by cadherin biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 5 MGI:MGI:88354|MGI:MGI:88355|UniProtKB:P33151|UniProtKB:P10288|UniProtKB:P12830 PTSG_06458 GO:0045296 cadherin binding molecular_function MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_06458/PTSG_06458-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 3 UniProtKB:P10288|UniProtKB:P55290|MGI:MGI:107433 PTSG_11235 GO:0000902 cell morphogenesis biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 8 MGI:MGI:99218|UniProtKB:P10288|ZFIN:ZDB-GENE-980526-170|MGI:MGI:99217|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-040816-1|MGI:MGI:105057|MGI:MGI:88354 PTSG_11235 GO:0005912 adherens junction cellular_component REMOVE genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 10 MGI:MGI:105057|MGI:MGI:88356|MGI:MGI:88354|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|RGD:69280|UniProtKB:P33151|UniProtKB:P19022|MGI:MGI:88355|UniProtKB:P10288 PTSG_11235 GO:0007043 cell-cell junction assembly biological_process REMOVE genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 UniProtKB:P12830|MGI:MGI:88355|UniProtKB:P33151|MGI:MGI:88354 PTSG_11235 GO:0008013 beta-catenin binding molecular_function REMOVE genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 8 UniProtKB:P12830|UniProtKB:Q8IXH8|MGI:MGI:88354|RGD:69279|UniProtKB:P19022|UniProtKB:P33151|UniProtKB:Q86UP0|RGD:69280 PTSG_11235 GO:0016339 calcium-dependent cell-cell adhesion biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 6 MGI:MGI:88355|UniProtKB:P55290|RGD:2321|MGI:MGI:1095414|RGD:69280|MGI:MGI:88354 PTSG_11235 GO:0016342 catenin complex cellular_component REMOVE genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 5 MGI:MGI:88354|ZFIN:ZDB-GENE-990415-171|ZFIN:ZDB-GENE-010606-1|UniProtKB:P19022|UniProtKB:P12830 PTSG_11235 GO:0016477 cell migration biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 10 UniProtKB:Q96JQ0|ZFIN:ZDB-GENE-990415-171|UniProtKB:Q90763|UniProtKB:P55290|MGI:MGI:2685011|UniProtKB:P33151|MGI:MGI:88355|MGI:MGI:105057|UniProtKB:F1RFU7|ZFIN:ZDB-GENE-010606-1 PTSG_11235 GO:0034332 adherens junction organization biological_process REMOVE genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 4 ZFIN:ZDB-GENE-990415-171|UniProtKB:P12830|ZFIN:ZDB-GENE-010606-1|UniProtKB:P33151 PTSG_11235 GO:0044331 cell-cell adhesion mediated by cadherin biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN000616280 AN23 0 SPECIATION Bilateria Bilateria False False False 524 5 MGI:MGI:88354|MGI:MGI:88355|UniProtKB:P33151|UniProtKB:P10288|UniProtKB:P12830 PTSG_11235 GO:0045296 cadherin binding molecular_function MARK_AS_OVER_ANNOTATED genes/SALRS/PTSG_11235/PTSG_11235-ai-review.yaml PTHR24027 PTN000616280 AN23 ok True PTN008601603 AN0 4 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True True True 580 3 UniProtKB:P10288|UniProtKB:P55290|MGI:MGI:107433 couscous GO:0000026 alpha-1,2-mannosyltransferase activity molecular_function ACCEPT genes/SALRS/couscous/couscous-ai-review.yaml PTHR31646 PTN001270341 AN0 ok True PTN001270341 AN0 0 SPECIATION Eukaryota Eukaryota True True False 57 3 SGD:S000000219|CGD:CAL0000190919|SGD:S000003722 couscous GO:0005794 Golgi apparatus cellular_component UNDECIDED genes/SALRS/couscous/couscous-ai-review.yaml PTHR31646 PTN001270341 AN0 ok True PTN001270341 AN0 0 SPECIATION Eukaryota Eukaryota True True False 57 2 SGD:S000000219|SGD:S000003722 couscous GO:0046354 mannan biosynthetic process biological_process REMOVE genes/SALRS/couscous/couscous-ai-review.yaml PTHR31646 PTN001270341 AN0 ok True PTN001270341 AN0 0 SPECIATION Eukaryota Eukaryota True True False 57 6 CGD:CAL0000192056|CGD:CAL0000182010|CGD:CAL0000193748|CGD:CAL0000190919|CGD:CAL0000174283|CGD:CAL0000196006 hippo GO:0005737 cytoplasm cellular_component ACCEPT genes/SALRS/hippo/hippo-ai-review.yaml PTHR48012 PTN004698602 AN50 ok True PTN004698611 AN0 2 DUPLICATION True True 435 23 RGD:621643|UniProtKB:O00506|UniProtKB:Q388G0|WB:WBGene00013355|UniProtKB:Q4GZ66|UniProtKB:Q9Y4K4|PomBase:SPBC17F3.02|RGD:1561742|UniProtKB:Q9H2G2|UniProtKB:Q57ZC6|RGD:727809|FB:FBgn0023083|MGI:MGI:1346883|UniProtKB:Q9UEW8|FB:FBgn0263395|FB:FBgn0035001|UniProtKB:Q9P289|UniProtKB:Q9Y6E0|dictyBase:DDB_G0286359|dictyBase:DDB_G0283265|UniProtKB:O95747|WB:WBGene00001526|AGI_LocusCode:AT1G53165 warts GO:0000082 G1/S transition of mitotic cell cycle biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/warts/warts-ai-review.yaml PTHR24356 PTN001220369 AN1262 ok True PTN002390470 AN1153 1 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False False 56 2 UniProtKB:Q9NRM7|MGI:MGI:1354386 warts GO:0035329 hippo signaling biological_process ACCEPT genes/SALRS/warts/warts-ai-review.yaml PTHR24356 PTN001220369 AN1262 ok True PTN002390470 AN1153 1 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False False 56 5 UniProtKB:Q9NRM7|MGI:MGI:1333883|MGI:MGI:1354386|FB:FBgn0011739|UniProtKB:O95835 warts GO:0035556 intracellular signal transduction biological_process KEEP_AS_NON_CORE genes/SALRS/warts/warts-ai-review.yaml PTHR24356 PTN001220369 AN1262 ok True PTN000683254 AN2 4 DUPLICATION Archaea-Eukaryota True False True 1763 42 UniProtKB:Q15208|PomBase:SPAC1B9.02c|RGD:621888|SGD:S000000201|RGD:2082|UniProtKB:Q05655|UniProtKB:P17252|MGI:MGI:1333883|PomBase:SPAC821.12|RGD:3395|UniProtKB:Q9Y2H1|RGD:3399|PomBase:SPAPB18E9.02c|WB:WBGene00004032|MGI:MGI:1354386|RGD:61925|UniProtKB:Q96BR1|RGD:2081|UniProtKB:O15530|MGI:MGI:87986|FB:FBgn0011739|SGD:S000002898|UniProtKB:Q9HBY8|FB:FBgn0010379|UniProtKB:O00141|PomBase:SPAC24B11.11c|PomBase:SPAC22E12.14c|FB:FBgn0020386|UniProtKB:P31749|UniProtKB:Q9NRM7|MGI:MGI:97601|RGD:67383|MGI:MGI:97595|MGI:MGI:97598|UniProtKB:O95835|SGD:S000005460|FB:FBgn0003744|RGD:620968|SGD:S000002874|WB:WBGene00000102|UniProtKB:P05771|MGI:MGI:94906 warts GO:0043065 positive regulation of apoptotic process biological_process MARK_AS_OVER_ANNOTATED genes/SALRS/warts/warts-ai-review.yaml PTHR24356 PTN001220369 AN1262 ok True PTN002390470 AN1153 1 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False False 56 1 FB:FBgn0011739 warts GO:0046620 regulation of organ growth biological_process REMOVE genes/SALRS/warts/warts-ai-review.yaml PTHR24356 PTN001220369 AN1262 ok True PTN002390470 AN1153 1 SPECIATION Metazoa-Choanoflagellida Metazoa-Choanoflagellida True False False 56 1 MGI:MGI:1354386 yorkie GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/SALRS/yorkie/yorkie-ai-review.yaml PTHR10316 PTN002569196 AN156 ok True PTN000817101 AN0 4 SPECIATION Eumetazoa Eumetazoa False True True 91 5 UniProtKB:Q86UL8|MGI:MGI:1354953|MGI:MGI:1203522|UniProtKB:Q96QZ7|RGD:621855 yorkie GO:0007165 signal transduction biological_process KEEP_AS_NON_CORE genes/SALRS/yorkie/yorkie-ai-review.yaml PTHR10316 PTN002569196 AN156 ok True PTN000817101 AN0 4 SPECIATION Eumetazoa Eumetazoa False True True 91 2 MGI:MGI:1354953|RGD:621855 mcr-4 GO:0009244 lipopolysaccharide core region biosynthetic process biological_process MARK_AS_OVER_ANNOTATED genes/SALSP/mcr-4/mcr-4-ai-review.yaml PTHR30443 PTN002019543 AN23 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 mcr-4 GO:0016776 phosphotransferase activity, phosphate group as acceptor molecular_function MODIFY genes/SALSP/mcr-4/mcr-4-ai-review.yaml PTHR30443 PTN002019543 AN23 ok True PTN000764902 AN0 4 SPECIATION Eubacteria Eubacteria True True True 23 1 UniProtKB:P0CB39 sctN GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function REMOVE genes/SHIFL/sctN/sctN-ai-review.yaml PTHR15184 PTN001807734 AN52 ok True PTN008558586 AN4 7 DUPLICATION LUCA True False True 330 4 UniProtKB:P0ABB4|PomBase:SPAC222.12c|SGD:S000003882|UniProtKB:P06576 Q53353 GO:0010436 carotenoid dioxygenase activity molecular_function REMOVE genes/SPHPI/Q53353/Q53353-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 9 AGI_LocusCode:AT3G14440|AGI_LocusCode:AT3G24220|AGI_LocusCode:AT4G18350|AGI_LocusCode:AT3G63520|UniProtKB:P9WPR5|ZFIN:ZDB-GENE-010509-1|AGI_LocusCode:AT2G44990|FB:FBgn0002937|AGI_LocusCode:AT1G78390 Q53353 GO:0016121 carotene catabolic process biological_process REMOVE genes/SPHPI/Q53353/Q53353-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 10 AGI_LocusCode:AT3G63520|AGI_LocusCode:AT4G32810|MGI:MGI:2177469|MGI:MGI:1926923|UniProtKB:Q7XU29|UniProtKB:Q9BYV7|AGI_LocusCode:AT2G44990|UniProtKB:Q9HAY6|UniProtKB:Q8LIY8|AGI_LocusCode:AT4G19170 lsdB GO:0010436 carotenoid dioxygenase activity molecular_function REMOVE genes/SPHPI/lsdB/lsdB-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 9 AGI_LocusCode:AT3G14440|AGI_LocusCode:AT3G24220|AGI_LocusCode:AT4G18350|AGI_LocusCode:AT3G63520|UniProtKB:P9WPR5|ZFIN:ZDB-GENE-010509-1|AGI_LocusCode:AT2G44990|FB:FBgn0002937|AGI_LocusCode:AT1G78390 lsdB GO:0016121 carotene catabolic process biological_process REMOVE genes/SPHPI/lsdB/lsdB-ai-review.yaml PTHR10543 PTN000830280 AN1271 ok True PTN001631894 AN0 4 SPECIATION LUCA LUCA True True False 699 10 AGI_LocusCode:AT3G63520|AGI_LocusCode:AT4G32810|MGI:MGI:2177469|MGI:MGI:1926923|UniProtKB:Q7XU29|UniProtKB:Q9BYV7|AGI_LocusCode:AT2G44990|UniProtKB:Q9HAY6|UniProtKB:Q8LIY8|AGI_LocusCode:AT4G19170 lytN GO:0008932 lytic endotransglycosylase activity molecular_function REMOVE genes/STAAU/lytN/lytN-ai-review.yaml PTHR33734 PTN001856296 AN385 ok True PTN008659194 AN369 5 SPECIATION Eubacteria Eubacteria True False True 45 1 UniProtKB:P0AEZ7 mdr GO:0005743 mitochondrial inner membrane cellular_component UNDECIDED genes/STABO/mdr/mdr-ai-review.yaml PTHR43394 PTN008681462 AN226 no_same_term_ibd_on_path False mdr GO:0015421 ABC-type oligopeptide transporter activity molecular_function UNDECIDED genes/STABO/mdr/mdr-ai-review.yaml PTHR43394 PTN008681462 AN226 no_same_term_ibd_on_path False mdr GO:0090374 oligopeptide export from mitochondrion biological_process UNDECIDED genes/STABO/mdr/mdr-ai-review.yaml PTHR43394 PTN008681462 AN226 no_same_term_ibd_on_path False cfr GO:0030488 tRNA methylation biological_process REMOVE genes/STAWA/cfr/cfr-ai-review.yaml PTHR30544 PTN002022544 AN302 no_same_term_ibd_on_path False gas7a GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN002747256 AN0 15 SPECIATION Eukaryota Eukaryota True True True 309 29 PomBase:SPBC4C3.06|dictyBase:DDB_G0290233|PomBase:SPBC11C11.02|PomBase:SPAC13A11.01c|FB:FBgn0053094|UniProtKB:Q0JRZ9|PomBase:SPAC20G8.05c|SGD:S000000626|UniProtKB:Q9UNF0|SGD:S000004635|RGD:69411|FB:FBgn0259734|UniProtKB:O43586|MGI:MGI:1345181|dictyBase:DDB_G0274695|RGD:3247|dictyBase:DDB_G0271812|UniProtKB:Q9DDA9|FB:FBgn0037702|JaponicusDB:SJAG_03596|UniProtKB:Q9UKS6|WB:WBGene00018467|dictyBase:DDB_G0271676|UniProtKB:O14526|MGI:MGI:1891410|MGI:MGI:1345153|MGI:MGI:1335088|MGI:MGI:1321396|UniProtKB:Q9BY11 gas7a GO:0005886 plasma membrane cellular_component ACCEPT genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN002747256 AN0 15 SPECIATION Eukaryota Eukaryota True True True 309 16 RGD:3247|ZFIN:ZDB-GENE-040426-984|FB:FBgn0053094|WB:WBGene00018974|UniProtKB:Q9DDA9|PomBase:SPAC20G8.05c|FB:FBgn0037702|UniProtKB:O14526|MGI:MGI:1345153|UniProtKB:O43586|MGI:MGI:1321396|ZFIN:ZDB-GENE-120613-1|MGI:MGI:1345181|UniProtKB:Q9UNF0|MGI:MGI:3505790|RGD:69411 gas7a GO:0005905 clathrin-coated pit cellular_component ACCEPT genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN000552124 AN180 9 SPECIATION Bilateria Bilateria True False True 80 3 MGI:MGI:3505790|UniProtKB:O14526|UniProtKB:Q0JRZ9 gas7a GO:0030136 clathrin-coated vesicle cellular_component KEEP_AS_NON_CORE genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN000552124 AN180 9 SPECIATION Bilateria Bilateria True False True 80 1 UniProtKB:Q0JRZ9 gas7a GO:0048268 clathrin coat assembly biological_process ACCEPT genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN000552124 AN180 9 SPECIATION Bilateria Bilateria True False True 80 2 UniProtKB:Q0JRZ9|UniProtKB:O14526 gas7a GO:0048812 neuron projection morphogenesis biological_process ACCEPT genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN001890901 AN183 6 SPECIATION Chordata Chordata True False True 25 1 MGI:MGI:1202388 gas7a GO:0072583 clathrin-dependent endocytosis biological_process ACCEPT genes/TAKRU/A0A674PKV4/A0A674PKV4-ai-review.yaml PTHR23065 PTN007729058 AN225 ok True PTN000552124 AN180 9 SPECIATION Bilateria Bilateria True False True 80 3 UniProtKB:O14526|WB:WBGene00018974|UniProtKB:Q0JRZ9 TFP GO:0005634 nucleus cellular_component MARK_AS_OVER_ANNOTATED genes/THLAR/TFP/TFP-ai-review.yaml PTHR47435 PTN008234626 AN84 ok True PTN002355837 AN23 16 SPECIATION Embryophyta Embryophyta True False True 76 1 AGI_LocusCode:AT1G54040 TFP GO:0005829 cytosol cellular_component ACCEPT genes/THLAR/TFP/TFP-ai-review.yaml PTHR47435 PTN008234626 AN84 no_same_term_ibd_on_path False TFP GO:0030234 enzyme regulator activity molecular_function MODIFY genes/THLAR/TFP/TFP-ai-review.yaml PTHR47435 PTN008234626 AN84 ok True PTN001509219 AN20 18 SPECIATION Viridiplantae Viridiplantae True False True 78 1 AGI_LocusCode:AT1G54040 TFP GO:0080028 nitrile biosynthetic process biological_process ACCEPT genes/THLAR/TFP/TFP-ai-review.yaml PTHR47435 PTN008234626 AN84 ok True PTN002355837 AN23 16 SPECIATION Embryophyta Embryophyta True False True 76 6 AGI_LocusCode:AT3G16410|AGI_LocusCode:AT3G16390|AGI_LocusCode:AT5G48180|AGI_LocusCode:AT2G33070|AGI_LocusCode:AT3G16400|AGI_LocusCode:AT1G54040 PARA GO:0005737 cytoplasm cellular_component KEEP_AS_NON_CORE genes/TOBAC/PARA/PARA-ai-review.yaml PTHR11260 PTN004250175 AN2203 ok True PTN001680376 AN2 15 SPECIATION Eukaryota Eukaryota True False True 1734 1 AGI_LocusCode:AT1G78370 AmiC1 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/TRIV2/AmiC1/AmiC1-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 AmiC2 GO:0030288 outer membrane-bounded periplasmic space cellular_component ACCEPT genes/TRIV2/AmiC2/AmiC2-ai-review.yaml PTHR30404 PTN002018865 AN27 ok True PTN000764114 AN0 2 SPECIATION Eubacteria Eubacteria True True False 50 2 UniProtKB:P36548|UniProtKB:P63883 uap1.S GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity molecular_function ACCEPT genes/XENLA/uap1.S/uap1.S-ai-review.yaml PTHR11952 PTN008986934 AN89 ok True PTN000237224 AN2 13 SPECIATION Eukaryota Eukaryota True False True 306 7 AGI_LocusCode:AT1G31070|CGD:CAL0000180804|SGD:S000002261|UniProtKB:Q16222|FB:FBgn0259749|RGD:1561967|AGI_LocusCode:AT2G35020 uap1.S GO:0006048 UDP-N-acetylglucosamine biosynthetic process biological_process ACCEPT genes/XENLA/uap1.S/uap1.S-ai-review.yaml PTHR11952 PTN008986934 AN89 ok True PTN000237224 AN2 13 SPECIATION Eukaryota Eukaryota True False True 306 3 FB:FBgn0259749|CGD:CAL0000180804|SGD:S000002261 sctN GO:0046933 proton-transporting ATP synthase activity, rotational mechanism molecular_function REMOVE genes/YEREN/sctN/sctN-ai-review.yaml PTHR15184 PTN001807733 AN53 ok True PTN008558586 AN4 7 DUPLICATION LUCA True False True 330 4 UniProtKB:P0ABB4|PomBase:SPAC222.12c|SGD:S000003882|UniProtKB:P06576