Vesicle tethering subtree obsoletion

GO:0099022 and 4 children → MF GO:7770062 vesicle membrane tethering activity

AI Gene Review · projects/VESICLE_TETHERING_OBSOLETION · 2026

Bottom line

  • GO obsoleted vesicle tethering (5 process terms) and minted GO:7770062 vesicle membrane tethering activity.
  • 8 TRAPP reviews already MODIFY their obsolete GO:0099022 row to GO:0006888 ER to Golgi transport.
  • TMF1 fixed in #3237 (merged): its MF moves to GO:7770062, and the obsolete GO:0099041 row, core BP and new-term request are removed.

Tethering is the first contact

Why tethering became a function

  • Upstream: the terms represent a molecular function, the bridging of vesicle and target membranes.
  • Obsoleted: GO:0099022, GO:0099041 to Golgi, GO:0099044 to ER, GO:0090522 exocytosis, GO:0099069 synaptic exocytosis.
  • Pattern (ValWood): MF part_of the transport BP, e.g. GO:7770062 part_of GO:0006888.
  • InterPro2GO flagged IPR007225, IPR039682 and IPR028280; recheck those plus 2 UniRule mappings before new reviews.

Who holds the rows

What changed in this repo

Next steps

  1. #3237 merged (TMF1 and USO1 → GO:7770062).
  2. New reviews: EXOC4, EXOC6, C17orf75/Njmu-R1, then TRIP11, GOLGA5, GORAB, RAB6A.
  3. Keep wording consistent with docking; EXOC4/EXOC6 are shared, host each once.

Siblings: VESICLE_DOCKING_OBSOLETION (#6379) · SYNAPTIC_VESICLE_DOCKING_OBSOLETION (#6415) · VESICLE_TARGETING_OBSOLETION (#6424)
Upstream: go-annotation#6375 · go-ontology#31868, #31871, #31872, #31881