Yeast cell cycle and translation control

A scoped review of 23 S. cerevisiae genes at the G1/S transition

AI Gene Review · projects/YEAST_CELL_CYCLE · scoping

Bottom line

  • Scoped, partly reviewed. The plan spans 23 rows covering Start, the cyclins and CDK, and the translation machinery.
  • The question: does GO capture translational control of the cell cycle as well as the transcriptional program?
  • Status: 10 of 23 rows have reviews (493 annotations); 13 still need review or symbol triage.

The circuit the project covers

Why this set

  • Start is one of the best-understood decision circuits in biology, so GO annotations can be checked against a clear mechanism.
  • Recent work proposes that translation capacity (TORC1, ribosome biogenesis, initiation factors) helps time Start, a layer GO rarely links to the cell cycle.
  • The review would separate core cell-cycle functions from pleiotropic growth effects that tend to be over-annotated to cell-cycle terms.

Where the list stands

Before starting

  • Fix the symbols. Yeast eIF1 is SUI1; EIF3 is a complex, not a gene; EIF2A is the reviewed SUI2 row.
  • Confirm why SHE2 belongs before treating it as ribosome biogenesis.
  • Finish the 13 open rows tracked in #3960.

Read more: projects/YEAST_CELL_CYCLE.md