{
 "gene": "ABCA1",
 "run_date": "2026-06-09T22:02:36",
 "timeline": {
  "current_model": "ABCA1 is an ATP-hydrolyzing integral membrane transporter that extracts phospholipids from the outer leaflet of the plasma membrane and flips them through a hydrophobic gateway/annulus tunnel into extracellular apoA-I, simultaneously generating lipid domains on the cell surface to which apoA-I binds (directly to ABCA1 at ~10% capacity and to lipid microdomains at ~90% capacity), enabling solubilization of cholesterol and phospholipids into nascent discoidal HDL particles; its activity is regulated transcriptionally by LXR/RXR, RAR, PPAR, AMPK-LXR\u03b1, HIF-1\u03b2, and multiple repressors (OSBP, ORP8, TRAK2, p62/mTOR), post-translationally by calpain-mediated degradation (destabilized by unsaturated fatty acid\u2013activated PLD2 phosphorylation, AGE-RAGE-ubiquitin/lysosome pathways, and OSBP), and by endosomal recycling (clathrin/Rab5 endocytosis; Rab4/ARF6-regulated return to plasma membrane); beyond cholesterol efflux, ABCA1 suppresses TLR4-driven macrophage inflammation through membrane lipid raft remodeling, activates JAK2/STAT3, PKA, PKC, and CDC42 signaling upon apoA-I binding, controls beta-cell cholesterol homeostasis and insulin secretion, regulates hepatic VLDL secretion, modulates aqueous humor outflow via a caveolin-1/eNOS/NO pathway, maintains brain apoE lipidation and neuroinflammatory tone in an astrocyte-specific manner, and exerts tumor-suppressor function in myeloid cells by restraining IL-3R\u03b2/MAPK/JAK2 signaling."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140657",
     "term_label": "ATP-dependent activity",
     "supporting_discovery_ids": [
      1
     ]
    },
    {
     "term_id": "GO:0016787",
     "term_label": "hydrolase activity",
     "supporting_discovery_ids": [
      1
     ]
    },
    {
     "term_id": "GO:0005215",
     "term_label": "transporter activity",
     "supporting_discovery_ids": [
      0,
      15
     ]
    },
    {
     "term_id": "GO:0008289",
     "term_label": "lipid binding",
     "supporting_discovery_ids": [
      1,
      15
     ]
    },
    {
     "term_id": "GO:0140104",
     "term_label": "molecular carrier activity",
     "supporting_discovery_ids": [
      0,
      2
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      2,
      6,
      15
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      3,
      14
     ]
    },
    {
     "term_id": "GO:0005764",
     "term_label": "lysosome",
     "supporting_discovery_ids": [
      20,
      25
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "GO:0005215",
     "term_label": "transporter activity",
     "supporting_discovery_ids": [
      0
     ]
    },
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      0,
      30
     ]
    },
    {
     "term_id": "R-HSA-382551",
     "term_label": "Transport of small molecules",
     "supporting_discovery_ids": [
      0,
      15
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      26,
      27,
      29
     ]
    },
    {
     "term_id": "R-HSA-5653656",
     "term_label": "Vesicle-mediated transport",
     "supporting_discovery_ids": [
      3,
      6
     ]
    },
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      5,
      16,
      21
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "APOA1",
    "STX13",
    "FLOT1",
    "OSBP",
    "PMP22",
    "TRAK2",
    "ARF6",
    "CAV1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "O95477",
   "full_name": "Phospholipid-transporting ATPase ABCA1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.300751
 }
}