{
 "gene": "ABL1",
 "run_date": "2026-06-09T22:02:37",
 "timeline": {
  "current_model": "c-Abl is a non-receptor tyrosine kinase held in an autoinhibited state by intramolecular engagement of its N-terminal myristoyl group with the kinase domain (stabilizing SH2/SH3 docking), and is activated by displacement of this myristoyl latch, phosphotyrosine ligands, upstream kinases DNA-PK and ATM (in response to DNA damage), integrin-mediated cell adhesion, and reactive oxygen species; once active it phosphorylates a wide array of substrates\u2014including p73, TAp63, YAP (Y357), \u03b1-synuclein (Y39), PARIS (Y137), RAD51 (Y315), Dok1 (Y361), WAVE3, Lamellipodin, PARP1 (Y829), GSK3\u03b2 (Y216), TFEB, and MAVS\u2014to regulate DNA damage-induced apoptosis and cell-cycle arrest (via p53/p21), actin cytoskeletal remodeling and cell migration, autophagy-lysosomal function, innate immune signaling, and neurodegeneration; activated c-Abl is downregulated by ubiquitin-proteasome-mediated degradation, and its kinase activity is directly inhibited by F-actin binding to its C-terminal domain."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      3,
      6,
      9,
      13,
      14,
      19,
      24,
      36
     ]
    },
    {
     "term_id": "GO:0016740",
     "term_label": "transferase activity",
     "supporting_discovery_ids": [
      1,
      3,
      6,
      14,
      19,
      25,
      27,
      34
     ]
    },
    {
     "term_id": "GO:0003677",
     "term_label": "DNA binding",
     "supporting_discovery_ids": [
      18
     ]
    },
    {
     "term_id": "GO:0008092",
     "term_label": "cytoskeletal protein binding",
     "supporting_discovery_ids": [
      8,
      43
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      7,
      18,
      27
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      7,
      12
     ]
    },
    {
     "term_id": "GO:0000228",
     "term_label": "nuclear chromosome",
     "supporting_discovery_ids": [
      25,
      38
     ]
    },
    {
     "term_id": "GO:0005856",
     "term_label": "cytoskeleton",
     "supporting_discovery_ids": [
      8,
      43
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-73894",
     "term_label": "DNA Repair",
     "supporting_discovery_ids": [
      4,
      5,
      25
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      3,
      9,
      10,
      11
     ]
    },
    {
     "term_id": "R-HSA-9612973",
     "term_label": "Autophagy",
     "supporting_discovery_ids": [
      34,
      35
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      7,
      13,
      24,
      33
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      21,
      27,
      28
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      19,
      36,
      39
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "ATM",
    "DNA-PK",
    "P73",
    "CRK",
    "BRCA1",
    "GSK3B",
    "MAVS",
    "YAP1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P00519",
   "full_name": "Tyrosine-protein kinase ABL1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.279308
 }
}