{
 "gene": "AGO2",
 "run_date": "2026-06-09T22:02:42",
 "timeline": {
  "current_model": "AGO2 is the catalytic core of the RNA-induced silencing complex (RISC), performing endonucleolytic cleavage of target mRNAs guided by loaded small RNAs (miRNAs/siRNAs); its activity is regulated by multiple post-translational modifications (phosphorylation at S387 by MEK, acetylation by p300/CBP/HDAC7, malonylation by cytoplasmic SIRT3), by chaperone-mediated loading (Hsp90/p23/FKBP4), and by autophagy-dependent degradation via NDP52; AGO2 subcellular localization (cytoplasm vs. nucleus vs. mitochondria) is dynamically controlled by the Pi3K-AKT-mTOR pathway and determines distinct functional outputs\u2014cytoplasmic RISC-mediated mRNA silencing, nuclear transcriptional regulation and transposon repression (via catalytic slicer activity), and mitochondrial translation activation via TUFM recruitment; AGO2 also engages KRAS at the ER, promotes telomerase activity through TERT-TERC association, facilitates homologous recombination by recruiting Rad51 to double-strand breaks, and participates in transcriptional activation via the RITA complex at promoters."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140098",
     "term_label": "catalytic activity, acting on RNA",
     "supporting_discovery_ids": [
      15,
      2,
      21,
      24
     ]
    },
    {
     "term_id": "GO:0003723",
     "term_label": "RNA binding",
     "supporting_discovery_ids": [
      13,
      14,
      24,
      15
     ]
    },
    {
     "term_id": "GO:0140110",
     "term_label": "transcription regulator activity",
     "supporting_discovery_ids": [
      3,
      0,
      22
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      7,
      21
     ]
    },
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      0,
      10,
      21,
      23
     ]
    },
    {
     "term_id": "GO:0005739",
     "term_label": "mitochondrion",
     "supporting_discovery_ids": [
      20
     ]
    },
    {
     "term_id": "GO:0005783",
     "term_label": "endoplasmic reticulum",
     "supporting_discovery_ids": [
      5
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      4
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-8953854",
     "term_label": "Metabolism of RNA",
     "supporting_discovery_ids": [
      1,
      11,
      15,
      7
     ]
    },
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      0,
      3,
      6,
      22
     ]
    },
    {
     "term_id": "R-HSA-73894",
     "term_label": "DNA Repair",
     "supporting_discovery_ids": [
      2
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      5,
      4
     ]
    }
   ],
   "complexes": [
    "RISC",
    "RITA complex"
   ],
   "partners": [
    "KRAS",
    "RAD51",
    "TUFM",
    "FAM120A",
    "MOV10",
    "MSI1",
    "YTHDF1",
    "EIF1A"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q9UKV8",
   "full_name": "Protein argonaute-2"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 6,
  "faith_total": 6,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.223549
 }
}