{
 "gene": "CALM1",
 "run_date": "2026-06-09T22:57:17",
 "timeline": {
  "current_model": "CALM1 encodes calmodulin, a Ca\u00b2\u207a sensor protein whose pathogenic missense variants (e.g., F142L, N98S, E141G) impair Ca\u00b2\u207a-dependent inactivation (CDI) of the cardiac L-type calcium channel CaV1.2, leading to prolonged action potential duration and ventricular arrhythmias; additionally, CALM1 participates in neuronal migration and axon elongation through a CaM-dependent pathway, and its long 3'-UTR isoform has isoform-specific roles in neural development, while the three CALM genes exhibit differential transcriptional activity with CALM1's 5' UTR being required for full promoter activation."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      0,
      1,
      2
     ]
    },
    {
     "term_id": "GO:0140299",
     "term_label": "molecular sensor activity",
     "supporting_discovery_ids": [
      0
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      5,
      6
     ]
    }
   ],
   "pathway": [],
   "complexes": [],
   "partners": [
    "CACNA1C",
    "SCN5A",
    "FMR1",
    "CAMKK2"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P0DP23",
   "full_name": "Calmodulin-1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 5,
  "faith_total": 6,
  "faith_pct": 83.33333333333333
 },
 "cost": {
  "total_usd": 0.136571
 }
}