{
 "gene": "CFTR",
 "run_date": "2026-06-09T22:57:18",
 "timeline": {
  "current_model": "CFTR (ABCC7) is a PKA-phosphorylated, ATP-gated anion (Cl-/HCO3-) channel located at the apical membrane of epithelial cells and endosomes, whose gating requires R-domain phosphorylation to enable allosteric coupling of NBD dimerization/ATP hydrolysis to a gate localized in TM6 (residues 337\u2013344); it is stabilized at the membrane by COMMD1-dependent protection from ubiquitination and regulated by PP2C phosphatase, WNK1 kinase, SNARE protein syntaxin 1A, and TMEM16A, while F508del-CFTR misfolding leads to Hsp70/DNAJA2/CHIP-dependent ER proteasomal and lysosomal degradation; beyond its chloride channel role CFTR also acts as a mechanosensitive channel, regulates ENaC, controls endothelial barrier integrity via a CFTR\u2192WNK1\u2192TRPV4 pathway, and supports neutrophil phagosomal HOCl production."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0005215",
     "term_label": "transporter activity",
     "supporting_discovery_ids": [
      1,
      3,
      6,
      14,
      16,
      19
     ]
    },
    {
     "term_id": "GO:0140657",
     "term_label": "ATP-dependent activity",
     "supporting_discovery_ids": [
      3,
      5,
      17
     ]
    },
    {
     "term_id": "GO:0140299",
     "term_label": "molecular sensor activity",
     "supporting_discovery_ids": [
      6
     ]
    },
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      7,
      23
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      1,
      6,
      11,
      22
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      19
     ]
    },
    {
     "term_id": "GO:0005783",
     "term_label": "endoplasmic reticulum",
     "supporting_discovery_ids": [
      2,
      12,
      13,
      20
     ]
    },
    {
     "term_id": "GO:0005794",
     "term_label": "Golgi apparatus",
     "supporting_discovery_ids": [
      21
     ]
    },
    {
     "term_id": "GO:0031410",
     "term_label": "cytoplasmic vesicle",
     "supporting_discovery_ids": [
      22
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-382551",
     "term_label": "Transport of small molecules",
     "supporting_discovery_ids": [
      1,
      3,
      6,
      14,
      16,
      19
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      2,
      12,
      13
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      8,
      9,
      21,
      23
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      0,
      2,
      9,
      23
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "PP2C",
    "WNK1",
    "STX1A",
    "COMMD1",
    "TMEM16A",
    "DNAJA2",
    "HSPA8",
    "PCBP1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P13569",
   "full_name": "Cystic fibrosis transmembrane conductance regulator"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.228026
 }
}