{
 "gene": "CPT1C",
 "run_date": "2026-06-09T22:57:19",
 "timeline": {
  "current_model": "CPT1C is a brain-specific ER-resident protein that senses malonyl-CoA levels to coordinate multiple neuronal functions: it acts as a low-efficiency palmitoyl thioesterase (depalmitoylating GluA1), promotes AMPAR (GluA1/GluA2) synthesis via mTORC1 and surface trafficking by inhibiting the PI(4)P phosphatase SAC1, facilitates anterograde lysosome/late-endosome transport by bridging protrudin and Kinesin-1, regulates hypothalamic ceramide and endocannabinoid metabolism to control food intake and BAT thermogenesis downstream of AMPK, and its own translation is controlled by a 5\u2032 UTR upstream ORF that is relieved by nutrient stress; in cancer cells CPT1C modulates lipid droplet biogenesis, plasma membrane composition, and fatty acid/ceramide metabolism to support survival under metabolic stress, and its protein levels are cell-cycle-regulated by APC/C-mediated degradation."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      8
     ]
    },
    {
     "term_id": "GO:0016740",
     "term_label": "transferase activity",
     "supporting_discovery_ids": [
      0
     ]
    },
    {
     "term_id": "GO:0140299",
     "term_label": "molecular sensor activity",
     "supporting_discovery_ids": [
      10,
      11
     ]
    },
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      11
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005783",
     "term_label": "endoplasmic reticulum",
     "supporting_discovery_ids": [
      0,
      10,
      11
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-112316",
     "term_label": "Neuronal System",
     "supporting_discovery_ids": [
      5,
      6,
      21
     ]
    },
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      2,
      9,
      17
     ]
    },
    {
     "term_id": "R-HSA-9609507",
     "term_label": "Protein localization",
     "supporting_discovery_ids": [
      10,
      11
     ]
    },
    {
     "term_id": "R-HSA-1640170",
     "term_label": "Cell Cycle",
     "supporting_discovery_ids": [
      15
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "GRIA1",
    "GRIA2",
    "ATL1",
    "ZFYVE27",
    "SACM1L",
    "ANKRD13",
    "ESRRA",
    "YY1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q8TCG5",
   "full_name": "Palmitoyl thioesterase CPT1C"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 11,
  "faith_total": 11,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.188516
 }
}