{
 "gene": "EGFR",
 "run_date": "2026-06-09T23:54:42",
 "timeline": {
  "current_model": "EGFR (ErbB1) is a ligand-activated receptor tyrosine kinase whose activity, signaling output, and fate are controlled by a multilayered network: ligand binding drives homo- or heterodimerization (with distinct dimer-dependent phosphorylation patterns and signaling properties), cytoplasmic conformational activators (cytohesins) facilitate kinase domain activation, ligand-occupied dimers are stabilized by co-confinement and cortical actin interactions, activated receptor undergoes accelerated clathrin-mediated internalization and lysosomal targeting (regulated by ubiquitination/deubiquitination via UBPY/USP22/FBXL2-Grp94 and trafficking regulators such as ARAP1), and constitutive vs. ligand-activated EGFR signaling can engage distinct downstream pathways (e.g., TAB1-TAK1-NF-\u03baB-EMP1 for invasion vs. BIN3-DOCK7 for invasion suppression), with additional modulation by sialylation state, transactivation by GPCRs and Wnt via metalloprotease-dependent ligand shedding, and stabilization/destabilization by kinases such as DYRK1A."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      0,
      6,
      18
     ]
    },
    {
     "term_id": "GO:0016740",
     "term_label": "transferase activity",
     "supporting_discovery_ids": [
      0,
      6
     ]
    },
    {
     "term_id": "GO:0140657",
     "term_label": "ATP-dependent activity",
     "supporting_discovery_ids": [
      6
     ]
    },
    {
     "term_id": "GO:0060089",
     "term_label": "molecular transducer activity",
     "supporting_discovery_ids": [
      0,
      16
     ]
    },
    {
     "term_id": "GO:0001618",
     "term_label": "virus receptor activity",
     "supporting_discovery_ids": [
      1
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      7,
      12
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      2,
      5,
      11
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      6
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      0,
      6,
      16
     ]
    },
    {
     "term_id": "R-HSA-5653656",
     "term_label": "Vesicle-mediated transport",
     "supporting_discovery_ids": [
      2,
      5
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      9,
      10,
      16
     ]
    },
    {
     "term_id": "R-HSA-1266738",
     "term_label": "Developmental Biology",
     "supporting_discovery_ids": [
      17,
      18
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "GRB2",
    "ARAP1",
    "USP8",
    "USP22",
    "FBXL2",
    "HSP90B1",
    "NEU3",
    "ITGB1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P00533",
   "full_name": "Epidermal growth factor receptor"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.21762
 }
}