{
 "gene": "FASN",
 "run_date": "2026-06-09T23:54:43",
 "timeline": {
  "current_model": "FASN is the sole multifunctional enzyme catalyzing de novo long-chain fatty acid synthesis from acetyl-CoA, malonyl-CoA and NADPH; it is regulated at the transcriptional level by SREBP-1/Sp1/FBI-1 and at the protein level by multiple E3 ligases (FBXW7\u03b2, TRIM21) that drive K48-ubiquitination/proteasomal degradation, counteracted by deubiquitinases (USP13, USP2) and by palmitoylation at specific cysteine residues (catalyzed by ZDHHC20 at C1471/C1881 and ZDHHC21 at C1317, and opposed by ZDHHC21 in some contexts); the palmitate it produces also drives palmitoylation of downstream signaling proteins including MYD88 (at C113, enabling IRAK4 recruitment), MHC-I (targeting it for lysosomal degradation via DHHC3), PD-L1, and mutant p53 (stabilizing gain-of-function mutp53), thereby coupling lipid metabolism to innate immune signaling, antigen presentation, immune evasion, and oncogenesis; FASN activity is additionally required for radial glia cell polarity and brain development, surfactant phospholipid homeostasis in alveolar type II cells, and autophagosome-lysosome fusion via interaction with SNARE complexes."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0016491",
     "term_label": "oxidoreductase activity",
     "supporting_discovery_ids": [
      29
     ]
    },
    {
     "term_id": "GO:0016740",
     "term_label": "transferase activity",
     "supporting_discovery_ids": [
      0,
      1,
      4
     ]
    },
    {
     "term_id": "GO:0140097",
     "term_label": "catalytic activity, acting on DNA",
     "supporting_discovery_ids": [
      29
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      19,
      20
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      19,
      24,
      29
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      0,
      1,
      11,
      12
     ]
    },
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      13,
      14
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      2,
      5,
      6
     ]
    },
    {
     "term_id": "R-HSA-9612973",
     "term_label": "Autophagy",
     "supporting_discovery_ids": [
      20,
      22
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      10
     ]
    },
    {
     "term_id": "R-HSA-1266738",
     "term_label": "Developmental Biology",
     "supporting_discovery_ids": [
      8
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "FBXW7",
    "TRIM21",
    "USP13",
    "USP2",
    "ZDHHC20",
    "ZDHHC21",
    "FABP5",
    "STX17"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P49327",
   "full_name": "Fatty acid synthase"
  }
 },
 "evaluation": {
  "pairwise": "tie",
  "faith_supported": 6,
  "faith_total": 6,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.274126
 }
}