{
 "gene": "G6PD",
 "run_date": "2026-06-09T23:54:44",
 "timeline": {
  "current_model": "G6PD is the rate-limiting enzyme of the pentose phosphate pathway that produces NADPH by oxidizing glucose-6-phosphate; its activity is tightly regulated by multiple post-translational modifications\u2014including inhibitory acetylation (K403, removed by SIRT2; K171) and activating phosphorylation (Y112 by c-Src, Y437 by JAK2, T91 by CDK5), inhibitory glutarylation (removed by SIRT5), activating O-GlcNAcylation, inhibitory arginine methylation (R246, by BHMT), and inhibitory ubiquitination (K366/K403 by VHL E3 ligase)\u2014as well as by direct protein\u2013protein interactions with PTEN, Aldob-p53 complexes, BAG3, FDX1, HSPB1, and PAK4/p53/Mdm2, all of which modulate its capacity to form catalytically active dimers and thereby control NADPH-dependent redox homeostasis, nucleotide biosynthesis, and cell survival."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0016491",
     "term_label": "oxidoreductase activity",
     "supporting_discovery_ids": [
      2,
      6,
      17
     ]
    },
    {
     "term_id": "GO:0016787",
     "term_label": "hydrolase activity",
     "supporting_discovery_ids": [
      0,
      1
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      11
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      2,
      6,
      8
     ]
    },
    {
     "term_id": "R-HSA-8953897",
     "term_label": "Cellular responses to stimuli",
     "supporting_discovery_ids": [
      0,
      1,
      19
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      8,
      12
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "PTEN",
    "SIRT2",
    "ALDOB",
    "BAG3",
    "FDX1",
    "HSPB1",
    "VHL",
    "PAK4"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P11413",
   "full_name": "Glucose-6-phosphate 1-dehydrogenase"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 8,
  "faith_total": 8,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.244747
 }
}