{
 "gene": "HDAC6",
 "run_date": "2026-06-10T01:55:21",
 "timeline": {
  "current_model": "HDAC6 is a cytoplasmic class IIb deacetylase with two catalytic domains and a C-terminal ZnF-UBP ubiquitin-binding domain; it deacetylates multiple non-histone substrates including alpha-tubulin (regulating microtubule dynamics and cell motility), Hsp90 (controlling chaperone activity and client protein maturation), cortactin (regulating actin dynamics and angiogenesis), RIG-I (activating antiviral RNA sensing), MLH1 (disrupting mismatch repair complex assembly), TRIM21 (promoting antiviral intracellular neutralization), titin (modulating sarcomere stiffness and cardiac diastolic function), and TET2 (initiating DNA demethylation in response to valine deprivation); additionally, HDAC6 acts as a valine sensor via its primate-specific SE14 domain controlling nucleo-cytoplasmic shuttling, functions as an E3 ubiquitin ligase for substrates such as Chk1, serves as a dynein adapter for transport of ubiquitinated cargoes and inflammasome components to the MTOC, and engages p97/VCP through its ZnF-UBP to regulate polyubiquitin chain turnover and aggresome formation."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      0,
      1,
      3,
      5,
      7,
      10,
      17,
      21
     ]
    },
    {
     "term_id": "GO:0016740",
     "term_label": "transferase activity",
     "supporting_discovery_ids": [
      20
     ]
    },
    {
     "term_id": "GO:0016874",
     "term_label": "ligase activity",
     "supporting_discovery_ids": [
      9
     ]
    },
    {
     "term_id": "GO:0140313",
     "term_label": "molecular sequestering activity",
     "supporting_discovery_ids": [
      2,
      19
     ]
    },
    {
     "term_id": "GO:0060090",
     "term_label": "molecular adaptor activity",
     "supporting_discovery_ids": [
      8
     ]
    },
    {
     "term_id": "GO:0140299",
     "term_label": "molecular sensor activity",
     "supporting_discovery_ids": [
      21
     ]
    },
    {
     "term_id": "GO:0008092",
     "term_label": "cytoskeletal protein binding",
     "supporting_discovery_ids": [
      0
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      0
     ]
    },
    {
     "term_id": "GO:0005856",
     "term_label": "cytoskeleton",
     "supporting_discovery_ids": [
      0,
      17
     ]
    },
    {
     "term_id": "GO:0005815",
     "term_label": "microtubule organizing center",
     "supporting_discovery_ids": [
      8,
      11
     ]
    },
    {
     "term_id": "GO:0005764",
     "term_label": "lysosome",
     "supporting_discovery_ids": [
      6
     ]
    },
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      21
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      5,
      8,
      10
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      1,
      2
     ]
    },
    {
     "term_id": "R-HSA-9612973",
     "term_label": "Autophagy",
     "supporting_discovery_ids": [
      6,
      8
     ]
    },
    {
     "term_id": "R-HSA-73894",
     "term_label": "DNA Repair",
     "supporting_discovery_ids": [
      7
     ]
    },
    {
     "term_id": "R-HSA-4839726",
     "term_label": "Chromatin organization",
     "supporting_discovery_ids": [
      27
     ]
    },
    {
     "term_id": "R-HSA-1640170",
     "term_label": "Cell Cycle",
     "supporting_discovery_ids": [
      9
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "HSP90",
    "CTTN",
    "RIGI",
    "TRIM21",
    "MLH1",
    "VCP",
    "GRK2",
    "TET2"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q9UBN7",
   "full_name": "Protein deacetylase HDAC6"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.269236
 }
}