{
 "gene": "ILK",
 "run_date": "2026-06-10T01:55:23",
 "timeline": {
  "current_model": "ILK is a bona fide pseudokinase (lacking intrinsic kinase activity, with a degraded active site confirmed by crystallography and in vitro assays) that functions as the central scaffold of the heterotrimeric IPP (ILK\u2013PINCH\u2013Parvin) complex at integrin-containing focal adhesions; it links \u03b21/\u03b23 integrin cytoplasmic tails to the actin cytoskeleton by recruiting PINCH (via its ankyrin repeat domain) and Parvin (via its pseudokinase domain), with the Mg-ATP-occupied pseudoactive site allosterically enabling F-actin bundling through WH2 motifs on PINCH and Parvin; ILK also interacts with paxillin (LD1 motif), kindlin-2 (C-lobe of pseudokinase domain), ELMO2/RhoG, Rictor (mTORC2), and thymosin-\u03b24, thereby coordinating integrin-to-actin linkage, microtubule plus-end polarization, mechanotransduction, VEGFR3 regulation, and downstream signaling through Akt/PKB and GSK-3\u03b2."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0060090",
     "term_label": "molecular adaptor activity",
     "supporting_discovery_ids": [
      1,
      3,
      19,
      20
     ]
    },
    {
     "term_id": "GO:0008092",
     "term_label": "cytoskeletal protein binding",
     "supporting_discovery_ids": [
      4,
      19
     ]
    },
    {
     "term_id": "GO:0140657",
     "term_label": "ATP-dependent activity",
     "supporting_discovery_ids": [
      19,
      14
     ]
    },
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      21
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      1,
      4,
      7,
      20
     ]
    },
    {
     "term_id": "GO:0005856",
     "term_label": "cytoskeleton",
     "supporting_discovery_ids": [
      4,
      19
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      13,
      22
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-1474244",
     "term_label": "Extracellular matrix organization",
     "supporting_discovery_ids": [
      7,
      4,
      19
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      5,
      8,
      15,
      21
     ]
    },
    {
     "term_id": "R-HSA-1266738",
     "term_label": "Developmental Biology",
     "supporting_discovery_ids": [
      4,
      17,
      21
     ]
    }
   ],
   "complexes": [
    "IPP (ILK-PINCH-Parvin) complex",
    "focal adhesion",
    "ELMO2-RhoG-ILK (ERI) complex",
    "ILK-Rictor (mTORC2)"
   ],
   "partners": [
    "PINCH",
    "PARVIN",
    "PXN",
    "FERMT2",
    "ELMO2",
    "RICTOR",
    "RHOG",
    "ILKAP"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q13418",
   "full_name": "Scaffold protein ILK"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 8,
  "faith_total": 8,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.236584
 }
}