{
 "gene": "INS",
 "run_date": "2026-06-10T01:55:23",
 "timeline": {
  "current_model": "The INS gene's susceptibility to type 1 diabetes (IDDM2 locus) is mechanistically linked to VNTR minisatellite alleles in its promoter region: class III alleles drive higher insulin mRNA expression in the thymus (facilitating central immune tolerance) but slightly lower expression in fetal pancreas compared to class I alleles, with transcriptional activity further modulated by G-quartet DNA structure formation at the ILPR; fine mapping localizes the causal variant(s) to a ~2-kb region containing the VNTR, -23HphI, and +1140A/C polymorphisms."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [],
   "localization": [],
   "pathway": [
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      0,
      1,
      2
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      0,
      3
     ]
    }
   ],
   "complexes": [],
   "partners": [],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P01308",
   "full_name": "Insulin"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 5,
  "faith_total": 5,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.106243
 }
}