{
 "gene": "MYC",
 "run_date": "2026-06-10T05:19:52",
 "timeline": {
  "current_model": "c-Myc is a nuclear bHLH-LZ transcription factor that heterodimerizes with Max to bind E-box elements and activate or repress target genes; it stimulates transcription primarily by releasing promoter-proximally paused RNA Pol II and, at high levels, amplifies the entire active gene expression program; it also activates RNA Pol I-dependent rDNA transcription in the nucleolus and directly engages the pre-replicative complex to promote DNA replication initiation independent of transcription; its protein stability is tightly controlled by sequential phosphorylation at S62 (stabilizing, by Ras/ERK, Pim, IKK\u03b1) and T58 (destabilizing, by GSK3\u03b2), followed by FBXW7/SCF-mediated ubiquitination and proteasomal degradation, with multiple deubiquitinases (USP28, USP37, USP36, USP43) and the CRY2-FBXL3 E3 ligase also regulating its turnover; additional PTMs including SUMOylation (promoting degradation, reversed by SENP1) and CK2 phosphorylation further modulate stability; upstream, c-MYC expression is transcriptionally activated by the Wnt/\u03b2-catenin/Tcf-4, PDGF/Src/Vav2/Rac, and Pim pathways and repressed by APC, TGF-\u03b2/Smad3, C/EBP\u03b1, and by its own negative autoregulation; c-Myc co-ordinates cell proliferation, ribosome biogenesis, DNA replication, and apoptosis (the latter largely through p53 stabilization), and is subject to negative feedback from ribosomal proteins L11 and S14 that bind MBII and displace the TRRAP coactivator."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140110",
     "term_label": "transcription regulator activity",
     "supporting_discovery_ids": [
      7,
      3,
      2,
      5,
      33
     ]
    },
    {
     "term_id": "GO:0003677",
     "term_label": "DNA binding",
     "supporting_discovery_ids": [
      7,
      33
     ]
    },
    {
     "term_id": "GO:0042393",
     "term_label": "histone binding",
     "supporting_discovery_ids": [
      7,
      5
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      7,
      4,
      9
     ]
    },
    {
     "term_id": "GO:0005730",
     "term_label": "nucleolus",
     "supporting_discovery_ids": [
      5
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      7,
      3,
      2,
      5
     ]
    },
    {
     "term_id": "R-HSA-69306",
     "term_label": "DNA Replication",
     "supporting_discovery_ids": [
      4,
      25
     ]
    },
    {
     "term_id": "R-HSA-1640170",
     "term_label": "Cell Cycle",
     "supporting_discovery_ids": [
      21,
      27,
      6
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      10,
      28,
      17,
      31,
      15,
      19,
      18,
      34
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      0,
      23,
      13
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      6,
      32
     ]
    }
   ],
   "complexes": [
    "Myc-Max",
    "pre-replicative complex (association)"
   ],
   "partners": [
    "MAX",
    "TRRAP",
    "FBXW7",
    "CRY2",
    "RPL11",
    "RPS14",
    "YY1",
    "SENP1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P01106",
   "full_name": "Myc proto-oncogene protein"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 5,
  "faith_total": 5,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.225493
 }
}