{
 "gene": "COXFA4",
 "run_date": "2026-06-09T22:57:19",
 "timeline": {
  "current_model": "COXFA4 (formerly NDUFA4/MLRQ) encodes a nuclear-encoded, late-stage assembly subunit of mitochondrial Complex IV (cytochrome c oxidase) that is required for full CIV activity and biogenesis; its loss impairs oxidative phosphorylation, triggers mitochondrial stress including mtDNA leakage and downstream polyamine pathway deficiency, and physically interacts with VDAC1, while its displacement from CIV by the paralog C15ORF48 suppresses NF-\u03baB-driven inflammation, and a second paralog COXFA4L2 can partially compensate when COXFA4 is lost."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0005198",
     "term_label": "structural molecule activity",
     "supporting_discovery_ids": [
      0,
      1,
      11
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005739",
     "term_label": "mitochondrion",
     "supporting_discovery_ids": [
      0,
      1,
      3,
      12
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      0,
      6
     ]
    }
   ],
   "complexes": [
    "Complex IV (cytochrome c oxidase)"
   ],
   "partners": [
    "VDAC1",
    "REEP1",
    "C15ORF48",
    "COXFA4L2",
    "COX6C",
    "COX5B"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "O00483",
   "full_name": "Cytochrome c oxidase subunit FA4"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.136587
 }
}