{
 "gene": "PARK7",
 "run_date": "2026-06-10T05:19:53",
 "timeline": {
  "current_model": "PARK7/DJ-1 is a multifunctional homodimeric protein whose activity is regulated by oxidation of the conserved Cys106 residue; it functions as an oxidative stress sensor and antioxidant that: (1) binds and inhibits the 20S proteasome to protect partially unfolded proteins from degradation; (2) promotes Nrf2 nuclear translocation and ARE-dependent transcription (including thioredoxin 1) to upregulate antioxidant defenses; (3) binds subunits of mitochondrial Complex I (NDUFA4, ND1) to maintain its activity; (4) acts downstream of PINK1/parkin to facilitate optineurin recruitment and selective mitophagy; (5) binds PDHB to inhibit PDHA phosphorylation and promote pyruvate dehydrogenase activity and OXPHOS in Treg cells; (6) stabilizes HIF-1\u03b1 by interacting with VHL and inhibiting its E3 ligase activity; (7) preserves the SAHH tetramer to support transsulfuration/glutathione biosynthesis and suppress ferroptosis; (8) binds BCL-XL in an oxidation-dependent manner to stabilize it and suppress apoptosis; (9) inhibits RANKL-driven osteoclastogenesis via SHP-1 activation; (10) acts as an extracellular DAMP activating TLR2/TLR4 when released from necrotic cells; and (11) is secreted via an autophagy-based unconventional pathway in response to oxidative stress."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      3,
      8,
      18
     ]
    },
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      10,
      12
     ]
    },
    {
     "term_id": "GO:0016209",
     "term_label": "antioxidant activity",
     "supporting_discovery_ids": [
      4,
      9
     ]
    },
    {
     "term_id": "GO:0140110",
     "term_label": "transcription regulator activity",
     "supporting_discovery_ids": [
      4,
      19
     ]
    },
    {
     "term_id": "GO:0140098",
     "term_label": "catalytic activity, acting on RNA",
     "supporting_discovery_ids": [
      5,
      6
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005739",
     "term_label": "mitochondrion",
     "supporting_discovery_ids": [
      0,
      1,
      2,
      16
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      3,
      11
     ]
    },
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      27
     ]
    },
    {
     "term_id": "GO:0005576",
     "term_label": "extracellular region",
     "supporting_discovery_ids": [
      21,
      22,
      23
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-8953897",
     "term_label": "Cellular responses to stimuli",
     "supporting_discovery_ids": [
      2,
      4,
      9
     ]
    },
    {
     "term_id": "R-HSA-9612973",
     "term_label": "Autophagy",
     "supporting_discovery_ids": [
      1,
      22
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      3,
      8,
      18
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      10,
      18,
      21,
      26
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      2,
      9
     ]
    },
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      9,
      10,
      16
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      15,
      25,
      26
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "NDUFA4",
    "BCL2L1",
    "VHL",
    "PDHB",
    "PYCR1",
    "RACK1",
    "NCF1",
    "HTT"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q99497",
   "full_name": "Parkinson disease protein 7"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 8,
  "faith_total": 8,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.2368
 }
}