{
 "gene": "RASA1",
 "run_date": "2026-06-10T06:43:36",
 "timeline": {
  "current_model": "RASA1 (p120RasGAP) is a multi-domain RasGTPase-activating protein that accelerates GTP hydrolysis on Ras (via an arginine-finger mechanism defined crystallographically) to terminate Ras signaling; it is recruited to the plasma membrane and focal adhesions through SH2-domain interactions with phosphotyrosine proteins (including FAK and receptor/non-receptor tyrosine kinases), where it forms complexes with p190RhoGAP (facilitating Rho inactivation and cell polarity), annexin A6, and integrin \u03b1-subunits (regulating integrin recycling); its catalytic activity is essential for lymphatic valve endothelial cell survival and function, for collagen IV export during vascular development, and for suppression of mTORC1 in an EPHB4/RASA1/mTORC1 endothelial signaling axis, with its expression transcriptionally controlled by the PITX1/PTP1B axis and post-transcriptionally suppressed by miRNAs including miR-132, miR-223, and miR-21."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      0,
      2,
      3,
      15,
      17
     ]
    },
    {
     "term_id": "GO:0098772",
     "term_label": "molecular function regulator activity",
     "supporting_discovery_ids": [
      0,
      2,
      15
     ]
    },
    {
     "term_id": "GO:0060089",
     "term_label": "molecular transducer activity",
     "supporting_discovery_ids": [
      10,
      11,
      14
     ]
    },
    {
     "term_id": "GO:0008289",
     "term_label": "lipid binding",
     "supporting_discovery_ids": [
      4,
      8
     ]
    },
    {
     "term_id": "GO:0060090",
     "term_label": "molecular adaptor activity",
     "supporting_discovery_ids": [
      9,
      10
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      4,
      8
     ]
    },
    {
     "term_id": "GO:0005856",
     "term_label": "cytoskeleton",
     "supporting_discovery_ids": [
      5,
      9,
      10
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      13
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      1
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      0,
      2,
      11,
      14,
      18
     ]
    },
    {
     "term_id": "R-HSA-1266738",
     "term_label": "Developmental Biology",
     "supporting_discovery_ids": [
      12,
      14,
      17,
      19
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      3,
      18
     ]
    },
    {
     "term_id": "R-HSA-1474244",
     "term_label": "Extracellular matrix organization",
     "supporting_discovery_ids": [
      19
     ]
    }
   ],
   "complexes": [
    "FAK-RASA1-p190RhoGAP focal adhesion complex"
   ],
   "partners": [
    "FAK",
    "ARHGAP35",
    "ANXA6",
    "RACK1",
    "KHDRBS1",
    "EPHB4",
    "DLC1",
    "ITGA1"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P20936",
   "full_name": "Ras GTPase-activating protein 1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.208432
 }
}