{
 "gene": "ROR1",
 "run_date": "2026-06-10T06:43:37",
 "timeline": {
  "current_model": "ROR1 is a transmembrane receptor tyrosine kinase (classified as a pseudokinase lacking intrinsic catalytic activity) that acts as a Wnt5a (and IGFBP5) receptor, signaling through Wnt5a-induced hetero-oligomerization with ROR2, recruitment of GEFs (DOCK2) via its cytoplasmic proline-rich domain, and activation of Rac1/RhoA and ERK1/2 to promote cancer cell proliferation and migration; it also phosphorylates HER3 at Tyr1307 (a kinase-independent-of-ErbB mechanism) to engage the MAYA/NSUN6-MST1/YAP axis for bone metastasis, and functions as a scaffold for cavin-1, CAV1, and CAVIN3 to maintain caveolae integrity and sustain multi-RTK pro-survival AKT signaling; its stability is maintained by HSP90\u03b1 and its surface expression requires N-linked glycosylation, while it can complex with TCL1 to amplify AKT-driven leukemogenesis."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      2,
      3
     ]
    },
    {
     "term_id": "GO:0060089",
     "term_label": "molecular transducer activity",
     "supporting_discovery_ids": [
      1,
      5,
      16
     ]
    },
    {
     "term_id": "GO:0060090",
     "term_label": "molecular adaptor activity",
     "supporting_discovery_ids": [
      7,
      8
     ]
    },
    {
     "term_id": "GO:0001618",
     "term_label": "virus receptor activity",
     "supporting_discovery_ids": [
      1,
      16
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005886",
     "term_label": "plasma membrane",
     "supporting_discovery_ids": [
      7,
      9
     ]
    },
    {
     "term_id": "GO:0005768",
     "term_label": "endosome",
     "supporting_discovery_ids": [
      8
     ]
    },
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      12
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      0,
      1,
      5,
      6
     ]
    },
    {
     "term_id": "R-HSA-1643685",
     "term_label": "Disease",
     "supporting_discovery_ids": [
      2,
      4,
      11,
      17
     ]
    },
    {
     "term_id": "R-HSA-5653656",
     "term_label": "Vesicle-mediated transport",
     "supporting_discovery_ids": [
      7,
      8
     ]
    },
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      13,
      22
     ]
    }
   ],
   "complexes": [
    "caveolae"
   ],
   "partners": [
    "ROR2",
    "DOCK2",
    "CAV1",
    "CAVIN1",
    "CAVIN3",
    "TCL1",
    "HSP90AA1",
    "CSNK1E"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q01973",
   "full_name": "Inactive tyrosine-protein kinase transmembrane receptor ROR1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.231986
 }
}