{
 "gene": "SIRT1",
 "run_date": "2026-06-10T07:46:32",
 "timeline": {
  "current_model": "SIRT1 is an NAD+-dependent protein deacetylase that acts as a central metabolic and stress sensor, directly deacetylating a broad range of histone and non-histone substrates\u2014including PGC-1\u03b1, FOXO transcription factors, LXR, eNOS, ROR\u03b3t, CHK2, WEE1, Ku70, XRCC1, HIF-2\u03b1, STAT3, p21, p62, and others\u2014to regulate energy metabolism, cell cycle progression, DNA repair, inflammation, and cell survival; its activity is modulated upstream by cellular NAD+ levels (raised by AMPK), by CDK1-mediated phosphorylation, and by autophagic degradation via a direct SIRT1-LC3 interaction during senescence and aging."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      0,
      1,
      2,
      5,
      6,
      7,
      9,
      10,
      11,
      17,
      18
     ]
    },
    {
     "term_id": "GO:0016787",
     "term_label": "hydrolase activity",
     "supporting_discovery_ids": [
      0,
      1,
      6,
      7,
      11
     ]
    },
    {
     "term_id": "GO:0140110",
     "term_label": "transcription regulator activity",
     "supporting_discovery_ids": [
      15
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      8,
      15
     ]
    },
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      8
     ]
    },
    {
     "term_id": "GO:0000228",
     "term_label": "nuclear chromosome",
     "supporting_discovery_ids": [
      15
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      0,
      1,
      13,
      20
     ]
    },
    {
     "term_id": "R-HSA-1640170",
     "term_label": "Cell Cycle",
     "supporting_discovery_ids": [
      3,
      6,
      11,
      16,
      18
     ]
    },
    {
     "term_id": "R-HSA-73894",
     "term_label": "DNA Repair",
     "supporting_discovery_ids": [
      2,
      7,
      14
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      5,
      16
     ]
    },
    {
     "term_id": "R-HSA-9612973",
     "term_label": "Autophagy",
     "supporting_discovery_ids": [
      8,
      10
     ]
    },
    {
     "term_id": "R-HSA-74160",
     "term_label": "Gene expression (Transcription)",
     "supporting_discovery_ids": [
      15,
      19
     ]
    }
   ],
   "complexes": [],
   "partners": [
    "PPARGC1A",
    "FOXO1",
    "LXR",
    "KU70",
    "CDK1",
    "CHK2",
    "WEE1",
    "MAP1LC3"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "Q96EB6",
   "full_name": "NAD-dependent protein deacetylase sirtuin-1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 6,
  "faith_total": 6,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.204238
 }
}