{
 "gene": "UCHL1",
 "run_date": "2026-06-10T10:51:56",
 "timeline": {
  "current_model": "UCHL1 is a neuronal-abundant deubiquitinating enzyme (cysteine/histidine-dependent UCH family) that maintains free ubiquitin homeostasis and directly deubiquitinates and stabilizes multiple substrates\u2014including TrkB, EGFR, HIF-1\u03b1, PKM, POM121, TAZ, CD13, CD36, AKT1, FDXR, PFKFB3, Sox17, RIPK1, RIPK3, and raptor\u2014to regulate synaptic plasticity, axonal integrity, mTOR complex balance (disrupting mTORC1/promoting mTORC2), translation initiation (eIF4F assembly), cardiac and pulmonary hypertrophy, immune signaling (NF-\u03baB via I\u03baB\u03b1; NLRP3 inflammasome; MHC I recycling in dendritic cells), glycolysis, osteoclastogenesis, and necroptosis; its catalytic cysteine C152 is a critical site of inactivation by reactive lipids generated during ischemia, and loss of its hydrolase activity impairs UPP function and worsens axonal injury after brain trauma."
 },
 "narrative": {
  "mechanism_profile": {
   "molecular_activity": [
    {
     "term_id": "GO:0140096",
     "term_label": "catalytic activity, acting on a protein",
     "supporting_discovery_ids": [
      39,
      5,
      6,
      7,
      13,
      27,
      30
     ]
    },
    {
     "term_id": "GO:0016787",
     "term_label": "hydrolase activity",
     "supporting_discovery_ids": [
      39,
      21
     ]
    }
   ],
   "localization": [
    {
     "term_id": "GO:0005829",
     "term_label": "cytosol",
     "supporting_discovery_ids": [
      34,
      36
     ]
    },
    {
     "term_id": "GO:0005634",
     "term_label": "nucleus",
     "supporting_discovery_ids": [
      1,
      31,
      34
     ]
    },
    {
     "term_id": "GO:0005739",
     "term_label": "mitochondrion",
     "supporting_discovery_ids": [
      17,
      32
     ]
    }
   ],
   "pathway": [
    {
     "term_id": "R-HSA-392499",
     "term_label": "Metabolism of proteins",
     "supporting_discovery_ids": [
      39,
      6,
      2,
      4,
      36
     ]
    },
    {
     "term_id": "R-HSA-162582",
     "term_label": "Signal Transduction",
     "supporting_discovery_ids": [
      7,
      8,
      30,
      38,
      2
     ]
    },
    {
     "term_id": "R-HSA-168256",
     "term_label": "Immune System",
     "supporting_discovery_ids": [
      19,
      22,
      33
     ]
    },
    {
     "term_id": "R-HSA-5357801",
     "term_label": "Programmed Cell Death",
     "supporting_discovery_ids": [
      10,
      11
     ]
    },
    {
     "term_id": "R-HSA-1430728",
     "term_label": "Metabolism",
     "supporting_discovery_ids": [
      13,
      25,
      18
     ]
    },
    {
     "term_id": "R-HSA-112316",
     "term_label": "Neuronal System",
     "supporting_discovery_ids": [
      23,
      35,
      7
     ]
    }
   ],
   "complexes": [
    "eIF4F",
    "mTORC1",
    "mTORC2",
    "NLRP3 inflammasome"
   ],
   "partners": [
    "TRKB",
    "EGFR",
    "AKT1",
    "HIF1A",
    "PKM",
    "NLRP3",
    "RIPK1",
    "RIPK3"
   ],
   "other_free_text": []
  }
 },
 "prefetch_data": {
  "uniprot": {
   "accession": "P09936",
   "full_name": "Ubiquitin carboxyl-terminal hydrolase isozyme L1"
  }
 },
 "evaluation": {
  "pairwise": "win",
  "faith_supported": 7,
  "faith_total": 7,
  "faith_pct": 100.0
 },
 "cost": {
  "total_usd": 0.318051
 }
}