module: dmel_erf1_erf3_termination_complex
title: eRF1-eRF3 translation termination complex in Drosophila melanogaster
label: eRF1-eRF3 termination complex
module_type: PROTEIN_COMPLEX
description: >-
  Eukaryotic translation termination is carried out by the release factors eRF1
  and eRF3. eRF1 recognizes all three stop codons in the ribosomal A site and
  triggers hydrolysis of the peptidyl-tRNA bond through its conserved GGQ motif.
  eRF3 is a translational GTPase that delivers eRF1 to the ribosome as a ternary
  complex with GTP; GTP hydrolysis by eRF3 accommodates eRF1 and accelerates
  peptide release.
summary: >-
  Stop-codon-decoding eRF1 and the GTPase eRF3 that together terminate
  translation.
concepts:
  - {id: GO:0018444, label: translation release factor complex}
notes: >-
  Two-subunit complex modelled one part per subunit. Ribosome recycling
  (Pelo/ABCE1-type factors) is outside this module.
parts:
- id: erf1_subunit
  label: eRF1 subunit
  role: stop-codon recognition and peptide release
  genes: [eRF1]
  function: {id: 'GO:0003747', label: translation release factor activity}
  processes:
  - {id: 'GO:0006415', label: translational termination}
- id: erf3_subunit
  label: eRF3 subunit
  role: GTPase that delivers eRF1 to the ribosome
  genes: [eRF3]
  function: {id: 'GO:0003924', label: GTPase activity}
  processes:
  - {id: 'GO:0006415', label: translational termination}
group: TRFC