module: dmel_iswi_complexes
title: ISWI chromatin remodeling complexes in Drosophila melanogaster
label: ISWI complexes
module_type: PROTEIN_COMPLEX
description: >-
  ISWI is an ATP-dependent chromatin remodeler that slides nucleosomes. In
  Drosophila the single ISWI ATPase is the catalytic subunit of several
  complexes defined by their accessory subunits. ACF (with Acf) and CHRAC
  (Acf plus the histone-fold pair Chrac-14 and Chrac-16) assemble and space
  regularly arrayed nucleosomes. NURF (with the large subunit E(bx)/NURF301,
  Caf1-55 and the pyrophosphatase Nurf-38) helps activate transcription of
  target genes, for example in ecdysone and JAK/STAT signaling. RSF, NORC and
  TORC (with Toutatis and CtBP) are further ISWI complexes; TORC is linked to
  transcriptional repression.
summary: >-
  ACF, CHRAC, NURF, RSF, NORC and TORC remodelers that share the ISWI ATPase.
concepts:
  - {id: GO:0031010, label: ISWI-type complex}
cellular_components:
  - {id: GO:0000785, label: chromatin}
variant_sets:
  - id: iswi_complex_forms
    label: ISWI-containing complexes
    selection: ONE_OR_MORE
    variants:
      - id: nurf
        label: NURF complex
        group: NURF
        complex_term: {id: GO:0016589, label: NURF complex}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
          Nurf-38: {id: GO:0004427, label: inorganic diphosphate phosphatase activity}
      - id: acf
        label: ACF complex
        group: ACF
        complex_term: {id: GO:0016590, label: ACF complex}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
      - id: chrac
        label: CHRAC complex
        group: CHRAC
        complex_term: {id: GO:0008623, label: CHRAC}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
      - id: rsf
        label: RSF complex
        group: RSF
        complex_term: {id: GO:0031213, label: RSF complex}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
      - id: norc
        label: NORC complex
        group: NORC
        complex_term: {id: GO:0090536, label: NoRC complex}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
      - id: torc
        label: TORC complex
        group: TORC
        complex_term: {id: GO:0031010, label: ISWI-type complex}
        unit_functions:
          Iswi: {id: GO:0140658, label: ATP-dependent chromatin remodeler activity}
notes: >-
  The six FlyBase subgroups are modelled as alternative complexes, so Iswi
  appears in each. RSF contains CG8677 (the Drosophila RSF1 homolog per
  FlyBase). TORC has no specific GO term and is grounded to ISWI-type complex.