module: dmel_mitochondrial_ribosome
title: Mitochondrial ribosome in Drosophila melanogaster
label: Mitochondrial ribosome
module_type: PROTEIN_COMPLEX
description: >-
  The mitochondrial ribosome (mitoribosome) translates the small set of
  mitochondrial-DNA-encoded mRNAs, which in animals encode core subunits of the
  respiratory chain and ATP synthase. It consists of a small subunit built on
  the mitochondrially encoded 12S-type rRNA (mt:srRNA) and a large subunit
  built on the 16S-type rRNA (mt:lrRNA), together with nuclear-encoded
  mitochondrial ribosomal proteins. Animal mitoribosomes are protein-rich: they
  contain bacterial-type ribosomal proteins plus many mitochondria-specific
  proteins. In Drosophila, loss of the small-subunit protein tko (mRpS12) causes
  the technical knockout phenotype of bang sensitivity.
summary: >-
  Small and large mitoribosomal subunits that translate mitochondrial-DNA-encoded
  mRNAs.
concepts:
  - {id: GO:0005761, label: mitochondrial ribosome}
cellular_components:
  - {id: GO:0005739, label: mitochondrion}
parts:
  - id: mito_small_subunit
    label: Mitochondrial small ribosomal subunit
    role: mRNA decoding subunit
    group: MRPS
    complex_term: {id: GO:0005763, label: mitochondrial small ribosomal subunit}
    function: {id: GO:0003735, label: structural constituent of ribosome}
    processes:
      - {id: GO:0032543, label: mitochondrial translation}
  - id: mito_large_subunit
    label: Mitochondrial large ribosomal subunit
    role: peptidyl transferase subunit
    group: MRPL
    complex_term: {id: GO:0005762, label: mitochondrial large ribosomal subunit}
    function: {id: GO:0003735, label: structural constituent of ribosome}
    processes:
      - {id: GO:0032543, label: mitochondrial translation}
notes: >-
  Parts follow the FlyBase subgroups MRPS and MRPL, which include the
  mitochondrially encoded rRNAs (mt:srRNA, mt:lrRNA) grounded to their FlyBase
  gene ids. FlyBase lists mRpS30 in both subunits and mRpS18A in the large
  subunit group; these placements are kept as curated by FlyBase. Some members
  of MRPS (for example Ptcd3, bonsai, CG4882, CG12848) carry non-ribosomal-protein
  names; they are kept as FlyBase-listed subunit members.