module: dmel_raps_insc_complex
title: Pins-Inscuteable (Raps-Insc) complex in Drosophila melanogaster
label: Pins-Inscuteable complex
module_type: PROTEIN_COMPLEX
description: >-
  Partner of Inscuteable (Pins, also called Raps) and Inscuteable (Insc) form a
  complex at the apical cortex of dividing neuroblasts. Insc binds the Par complex
  through Bazooka and recruits Pins, which with the G protein alpha subunit Galphai
  binds Mud (NuMA) and orients the mitotic spindle along the apical-basal axis. This
  coupling of cell polarity to spindle orientation ensures that basal cell-fate
  determinants segregate into the smaller ganglion mother cell during asymmetric
  neuroblast division.
summary: >-
  Insc-Pins complex that links the apical Par complex to spindle orientation in
  asymmetrically dividing neuroblasts.
concepts:
  - {id: GO:1990499, label: raps-insc complex}
parts:
  - id: inscuteable
    label: Inscuteable
    role: adaptor linking Bazooka to Pins
    genes: [insc]
    function: {id: GO:0008093, label: cytoskeletal adaptor activity}
    processes:
      - {id: GO:0055059, label: asymmetric neuroblast division}
  - id: pins
    label: Partner of Inscuteable (Pins)
    role: Galphai- and Mud-binding spindle orientation factor
    genes: [pins]
    function: {id: GO:0005092, label: GDP-dissociation inhibitor activity}
    processes:
      - {id: GO:0055059, label: asymmetric neuroblast division}
connections:
  - source: inscuteable
    target: pins
    connection_type: POSITIVELY_REGULATES
    description: Insc recruits Pins to the apical cortex of neuroblasts.
notes: >-
  Galphai, Mud and Bazooka bind the complex but are not members of the FlyBase
  group and are treated as context. Pins is also active in epithelia without Insc.
  Insc is given cytoskeletal adaptor activity (GO:0008093; GOA IMP, IBA) and
  Pins, whose GoLoco motifs bind GDP-Galphai, GDP-dissociation inhibitor
  activity (GO:0005092; GOA IBA).
group: RIC