module: dmel_rnase_p_mrp
title: RNase P and RNase MRP complexes in Drosophila melanogaster
label: RNase P and RNase MRP
module_type: PROTEIN_COMPLEX
description: >-
  Ribonuclease P removes the 5' leader from precursor tRNAs. Nuclear RNase P is
  a ribonucleoprotein whose catalytic RNA (RNaseP:RNA) is bound by several
  proteins; the related RNase MRP shares most of these proteins but has its own
  RNA (RNaseMRP:RNA) and cleaves other substrates, including pre-rRNA. In
  mitochondria, tRNA 5' processing is carried out by a protein-only RNase P made
  of a tRNA methyltransferase subunit (rswl, MRPP1 homolog), a short-chain
  dehydrogenase subunit (scu, MRPP2/HSD17B10 homolog) and the PRORP-type
  nuclease subunit (mldr).
summary: >-
  Nuclear RNase P and RNase MRP ribonucleoproteins and the protein-only
  mitochondrial RNase P.
concepts:
  - {id: GO:0030677, label: ribonuclease P complex}
  - {id: GO:0000172, label: ribonuclease MRP complex}
parts:
  - id: nuclear_rnase_p
    label: Nuclear RNase P
    role: nuclear pre-tRNA 5' leader removal
    group: RNASEP-N
    complex_term: {id: GO:0030677, label: ribonuclease P complex}
    function: {id: GO:0004526, label: ribonuclease P activity}
    processes:
      - {id: GO:0001682, label: tRNA 5'-leader removal}
  - id: rnase_mrp
    label: RNase MRP
    role: pre-rRNA processing endonuclease
    group: RNASEMRP
    complex_term: {id: GO:0000172, label: ribonuclease MRP complex}
    function: {id: GO:0000171, label: ribonuclease MRP activity}
    processes:
      - {id: GO:0006364, label: rRNA processing}
  - id: mitochondrial_rnase_p
    label: Mitochondrial RNase P
    role: mitochondrial pre-tRNA 5' leader removal
    group: RNASEP-M
    complex_term: {id: GO:0030678, label: mitochondrial ribonuclease P complex}
    unit_functions:
      mldr: {id: GO:0004526, label: ribonuclease P activity}
    processes:
      - {id: GO:0001682, label: tRNA 5'-leader removal}
notes: >-
  Parts follow FlyBase groups RNASEP-N, RNASEMRP and RNASEP-M. Nuclear RNase P
  and RNase MRP share Pop1, Pop4, Pop5, Rpp14a, Rpp14b, Rpp20, Rpp25 and Rpp30;
  FlyBase lists Rpp21 only in RNase P. The catalytic RNAs (RNaseP:RNA,
  RNaseMRP:RNA) are grounded to FlyBase gene ids. The ribonuclease activities
  are assigned to the whole nuclear complexes because the RNA subunit is
  catalytic; in the mitochondrial complex only the nuclease subunit (mldr) is
  given an activity. Substrate specificity of Drosophila RNase MRP has not been
  characterized directly and is inferred from other eukaryotes.