accession reviewed gene caution A0A022PQZ0 unreviewed A0A022PY49 unreviewed A0A022Q8P5 unreviewed A0A022QF08 unreviewed A0A022QIQ6 unreviewed A0A022QST3 unreviewed A0A022QZ73 unreviewed A0A022R2W9 unreviewed A0A022R8Q4 unreviewed A0A022RGP0 unreviewed A0A022S0M6 unreviewed A0A022S3G7 unreviewed A0A061DLV4 unreviewed A0A061DNM5 unreviewed A0A061E1J7 unreviewed A0A061E742 unreviewed A0A061EC45 unreviewed A0A061EEC7 unreviewed A0A061ERE5 unreviewed A0A061F5S0 unreviewed A0A061FDS1 unreviewed A0A061G7M6 unreviewed A0A067EGP5 unreviewed A0A067EIZ5 unreviewed A0A067EYD6 unreviewed A0A067FB75 unreviewed A0A067FQF0 unreviewed A0A067G6Z9 unreviewed A0A067H1C2 unreviewed A0A067H3M1 unreviewed A0A067XGX8 reviewed DAHP2 A0A067YMX8 reviewed XTH8 A0A072TY73 unreviewed A0A072UAK9 unreviewed A0A072VLX2 unreviewed A0A072VMJ0 unreviewed A0A072VWP2 unreviewed A0A078F395 unreviewed BnaC03g47610D A0A078FHZ3 unreviewed BnaC06g01080D A0A078G6B8 unreviewed BnaA08g25290D A0A078G8S0 unreviewed BnaA09g30250D A0A078GEF0 unreviewed BnaC06g24610D A0A078GF03 unreviewed BnaA05g17470D A0A078GM22 unreviewed BnaC05g25370D A0A078GW30 unreviewed BnaC06g10440D A0A078GY60 unreviewed BnaC05g09760D A0A078H3G8 unreviewed BnaA07g00360D A0A078H642 unreviewed BnaA09g16240D A0A078H8P8 unreviewed BnaA02g28740D A0A078HVI6 unreviewed BnaA08g03370D A0A078HZ19 unreviewed BnaA05g18620D A0A078I0B2 unreviewed BnaC06g01920D A0A078I3B7 unreviewed BnaC09g17320D A0A078IBN6 unreviewed BnaAnng09200D A0A078IDG6 unreviewed BnaA10g28230D A0A078IGR3 unreviewed BnaCnng16100D A0A078III4 unreviewed BnaCnng17940D A0A078IM32 unreviewed BnaC09g52920D A0A078IN56 unreviewed BnaA06g01420D A0A078IW16 unreviewed BnaA08g29200D A0A078J250 unreviewed BnaC07g51150D A0A078J3J0 unreviewed BnaC08g14930D A0A078J4R6 unreviewed BnaCnng37470D A0A078J580 unreviewed BnaC03g78280D A0A078JE31 unreviewed BnaAnng19750D A0A078JX48 unreviewed BnaCnng67150D A0A087X1C5 reviewed CYP2D7 Pseudogene in the majority of genomes but is protein-coding in others. The functional allele is thought to be rare A0A088MLT8 reviewed Iqcj-Schip1 A0A096MJ70 unreviewed Prdm16 Lacks conserved residue(s) required for the propagation of feature annotation A0A096MJU6 unreviewed Prdm1 A0A096MK99 unreviewed Parp4 A0A096MKE9 unreviewed Lig3 A0A096MKH3 unreviewed Mctp2 A0A0A0K2X9 unreviewed A0A0A0K8K8 unreviewed A0A0A0KR30 unreviewed A0A0A0KUH0 unreviewed A0A0A0KVH9 unreviewed A0A0A0L5H6 unreviewed A0A0A0L823 unreviewed A0A0A0L876 unreviewed A0A0A0L9L9 unreviewed A0A0A1H8I4 reviewed ais A0A0B4J1F4 reviewed Arrdc4 A0A0B4JCV5 unreviewed CG9898 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4JCY1 unreviewed subdued Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4JCY5 unreviewed Mhcl A0A0B4JD89 unreviewed Dmel\CG42694 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4JDB9 unreviewed eIF4EHP A0A0B4K6V8 unreviewed alpha-Est5 A0A0B4K7A7 unreviewed Dmel\CG43125 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4K7P3 unreviewed Dmel\CG43124 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4K7S5 unreviewed Stlk A0A0B4KEW6 unreviewed Amph A0A0B4KEY0 unreviewed Coop A0A0B4KF15 unreviewed mtt A0A0B4KFB1 unreviewed Dmel\CG30323 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4KFF6 unreviewed Drep2 A0A0B4KFH4 unreviewed Rpn8 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4KFR7 unreviewed Amph A0A0B4KGE6 unreviewed Rpn8 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4KGR6 unreviewed Mhcl A0A0B4KGZ0 unreviewed MBD-like A0A0B4KH64 unreviewed btz A0A0B4KHB9 unreviewed wrd A0A0B4KHP7 unreviewed wrd A0A0B4LEH6 unreviewed Ance-4 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4LFC4 unreviewed Dmel\CG6337 A0A0B4LFK8 unreviewed Dcr-2 A0A0B4LFP5 unreviewed hrm A0A0B4LG43 unreviewed Dmel\CG33225 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4LH86 unreviewed Dmel\CG13527 Lacks conserved residue(s) required for the propagation of feature annotation A0A0B4LHK8 unreviewed CG6982 A0A0B4U9L8 reviewed A0A0D1CFY3 unreviewed A0A0D1DVI4 unreviewed A0A0D1E3R8 unreviewed A0A0D1E8X3 unreviewed A0A0G2JT63 unreviewed Cyfip2 A0A0G2JTB0 unreviewed Tnks2 A0A0G2JTU1 unreviewed Ercc6 A0A0G2JUJ3 unreviewed Tslp A0A0G2JUX2 unreviewed Arap3 A0A0G2JUX8 unreviewed Klrc1 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2JV80 unreviewed Rdh11 A0A0G2JVM9 unreviewed Pasd1 A0A0G2JVP8 unreviewed Gba3 A0A0G2JVU1 unreviewed Itgb8 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2JW23 unreviewed Nlrp12 A0A0G2JX31 unreviewed Pot1 A0A0G2JYX9 unreviewed Irak1 A0A0G2JZ79 reviewed Sirt1 A0A0G2JZA7 unreviewed Cemip2 A0A0G2JZS4 unreviewed Tgds A0A0G2K0G0 unreviewed Runx1t1 A0A0G2K0H3 unreviewed Lrp6 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K0W3 unreviewed Ttyh3 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K1A2 unreviewed Mpo Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K1L5 unreviewed Reep2 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K1T5 unreviewed Eya2 A0A0G2K1Y9 unreviewed Aff2 A0A0G2K320 unreviewed Siglec1 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K4Q7 unreviewed Pkd1l3 Lacks conserved residue(s) required for the propagation of feature annotation A0A0G2K516 unreviewed Stx11 A0A0G2K5B0 reviewed Tbc1d24 A0A0G2K5G5 unreviewed Alkbh2 A0A0G2K5S7 unreviewed Entpd3 A0A0G2K5U3 unreviewed Endov A0A0G2K644 unreviewed Syt16 A0A0G2K687 unreviewed Rubcn A0A0G2K6D8 unreviewed Sirt4 A0A0G2K712 unreviewed Tbc1d5 A0A0G2K715 unreviewed Cep290 A0A0G2K8T1 unreviewed Giot1 A0A0G2KAE2 unreviewed Tusc3 A0A0G2KAH7 unreviewed Ext2 A0A0G2KB06 unreviewed Mapk11 A0A0G2KB60 unreviewed Rps6kc1 A0A0G2KBC9 reviewed Lilrb3l A0A0G2QC55 unreviewed Tssk4 A0A0H2UNG0 reviewed spuA A0A0H2XI47 reviewed fphI A0A0H2XJL0 reviewed fphH A0A0H3PEK7 reviewed tlyA A0A0J9YV76 unreviewed Oas1e A0A0K1SC59 reviewed ADA Unlike other Plasmodium adenosine deaminases, lacks S-methyl-5'-thioadenosine deaminase activity due to the presence of a Glu residue at position 171 instead of an Asp residue A0A0K2S4Q6 reviewed CD300H The sequence shown in this entry differs from the translation of the reference genome assembly (GRCh38/hg38) due to a variant (dbSNP:rs905709) in the reference genome which abolishes the intron 1 donor splice site leading to loss of CD300H transcripts A0A0K9NJZ0 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9NKY2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9NPF9 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9NTH7 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9NV15 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9NYI4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9P4E5 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9PIC7 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9PID0 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9PJQ8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation || The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9PT45 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0K9PYR1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A0N7KK42 unreviewed A0A0P0VP46 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A0Q3ECX7 unreviewed LOC100846866 A0A0Q3HBZ6 unreviewed LOC100833131 A0A0R0H690 unreviewed LOC100817332 A0A0R0HTU3 unreviewed A0A0R0II97 unreviewed A0A0R0JKH7 unreviewed A0A0R0KY19 unreviewed A0A0R4IAX5 reviewed ugl A0A0R4IK86 unreviewed whr1 A0A0R4IKA2 unreviewed rest A0A0R4IMY7 reviewed trpm2 A0A0R4IV01 unreviewed rps6kc1 A0A0R4IWF9 unreviewed apex1 A0A0S0WMR4 unreviewed PGRP-LC A0A0U3BRC5 reviewed GFDPS A0A0U9HVH4 unreviewed A0A120HUS7 reviewed cysE A0A126GUQ5 unreviewed Madm A0A139WBK0 unreviewed AUGUSTUS-3.0.2_34399 Lacks conserved residue(s) required for the propagation of feature annotation A0A139WGD2 unreviewed AUGUSTUS-3.0.2_33453 A0A1B0GR71 unreviewed Gm4924 A0A1B0GWQ8 unreviewed Mbd5 A0A1B1WAJ0 reviewed RAD1 A0A1B6Q7S5 unreviewed A0A1B8YAJ2 unreviewed suclg2 A0A1D5NZN4 unreviewed FSTL3 Lacks conserved residue(s) required for the propagation of feature annotation A0A1D5PKM6 unreviewed PDIA2 A0A1D5PZ51 unreviewed DPYSL3 A0A1D5QCL1 unreviewed ERP27 A0A1D5QD93 unreviewed PDIA2 A0A1D5QUW3 unreviewed CYFIP2 A0A1D5QZC2 unreviewed THNSL2 A0A1D5RK28 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A1D6JZU3 unreviewed LOC103634525 A0A1D6LQK5 unreviewed LOC103629697 A0A1D8PDV5 unreviewed RAC1 A0A1D8PFP3 unreviewed KEM1 A0A1D8PGA7 unreviewed A0A1D8PHF8 unreviewed WH11 A0A1D8PHZ0 unreviewed A0A1D8PIK2 unreviewed RAP1 A0A1D8PJ17 unreviewed HOS2 A0A1D8PJG1 unreviewed GPA2 A0A1D8PJK3 unreviewed ECM14 Lacks conserved residue(s) required for the propagation of feature annotation A0A1D8PJP6 unreviewed RUB1 A0A1D8PN42 unreviewed GPR1 A0A1D8PSX0 unreviewed VMA13 A0A1D8PT92 unreviewed A0A1I9LNN0 unreviewed TWD40-1 A0A1I9LS70 unreviewed RAF43 A0A1I9LTC7 unreviewed DXPS1 A0A1L1RW56 unreviewed CHPF2 A0A1L8EN25 unreviewed rhbdf2.S A0A1L8END5 unreviewed fam20a.2.S A0A1L8ENP1 unreviewed chpf.S A0A1L8ER13 unreviewed pdia2.S A0A1L8EV37 unreviewed fam20a.2.L A0A1L8EVH1 unreviewed chpf.L A0A1L8F2Y5 unreviewed aff2.S A0A1L8F603 unreviewed adamtsl2.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8F7H7 unreviewed aff2.L A0A1L8F8I9 reviewed whr1.L Was originally reported to be a serine/threonine-protein kinase. However, later studies have shown that the protein does not have kinase activity and is involved in transcription-coupled nucleotide excision repair A0A1L8F991 unreviewed rps6kl1.L A0A1L8FEA8 unreviewed dpysl4.S A0A1L8FG60 unreviewed pank4.S A0A1L8FQ07 unreviewed chpf2.S A0A1L8FY27 unreviewed jarid2.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8G152 unreviewed rps6kc1.S A0A1L8G5R4 unreviewed dpysl5.S A0A1L8G6S4 unreviewed rps6kc1.L A0A1L8G9S0 unreviewed pm20d2.L A0A1L8GFH0 unreviewed ror1.S Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8GLD7 unreviewed mlkl.L A0A1L8GM33 unreviewed ror1.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8GP52 unreviewed mst1.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8GR40 unreviewed cyfip2.S A0A1L8GRV7 unreviewed aebp1.S Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8GTY1 unreviewed hgf.S Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8GV71 unreviewed dpysl3.S A0A1L8GZD1 unreviewed hgf.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8H1Z9 unreviewed aebp1.L Lacks conserved residue(s) required for the propagation of feature annotation A0A1L8H238 unreviewed dpysl2.L A0A1L8HKV2 unreviewed crmp1.S A0A1L8HP64 unreviewed LOC108706963 A0A1L8HSX6 unreviewed thnsl2.L A0A1L8HYJ6 unreviewed LOC108714431 A0A1P8AWX3 unreviewed A0A1P8B2J0 unreviewed A0A1P8B4E4 unreviewed A0A1P8B554 reviewed TLP1 A0A1P8BDK6 unreviewed ARFA1B A0A1P8BFG8 unreviewed A0A1P8BG25 unreviewed BGLC1 A0A1P8BH65 unreviewed A0A1S3WXE9 unreviewed LOC107758954 A0A1S3WXX8 unreviewed LOC107759180 A0A1S3XQT1 unreviewed LOC107767671 A0A1S3XSG2 reviewed DAO1 A0A1S3YCF3 unreviewed LOC107774603 A0A1S3YJ02 unreviewed LOC107776684 A0A1S3Z1Q8 unreviewed LOC107782056 A0A1S3Z9E9 unreviewed LOC107784461 A0A1S4B7T2 unreviewed LOC107805397 A0A1S4BJF6 unreviewed LOC107808947 A0A1S4BT70 unreviewed LOC107811628 A0A1S4CDG9 unreviewed LOC107817826 A0A1S4CF99 unreviewed LOC107818361 A0A1S4CT47 unreviewed LOC107822273 A0A1S4D1H7 unreviewed LOC107824880 A0A1S4GA36 unreviewed A0A1S4GAV3 unreviewed A0A1S4GSP3 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A1S4GW26 unreviewed A0A1S4GWY8 unreviewed A0A1S4H2X0 unreviewed A0A1U7YMD6 unreviewed LOC104585731 A0A1U7Z626 unreviewed LOC104589634 A0A1U7ZQT0 unreviewed LOC104593098 A0A1U8A0V0 unreviewed LOC104595596 A0A1U8ANU7 unreviewed LOC104604965 A0A1U8AQS2 unreviewed LOC104602898 A0A1U8ARL8 unreviewed LOC104606846 A0A1U8B3W1 unreviewed LOC104610559 A0A1U8BHG0 unreviewed LOC104613532 A0A1U8BQ15 unreviewed LOC104613530 A0A1U8FLD2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8FTY5 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8FW96 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8GBI5 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8GFH9 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8GH87 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8HG63 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A1U8I3G6 unreviewed LOC107892256 A0A1U8I8P2 unreviewed LOC107892122 A0A1U8I979 unreviewed LOC107894008 A0A1U8I9V0 unreviewed LOC107894239 A0A1U8IFN4 unreviewed LOC107894005 A0A1U8J0N7 unreviewed LOC107902211 A0A1U8JBD2 unreviewed LOC107905467 A0A1U8JU98 unreviewed LOC107910507 A0A1U8KDI4 unreviewed LOC107915879 Lacks conserved residue(s) required for the propagation of feature annotation A0A1U8KH06 unreviewed LOC107915600 Lacks conserved residue(s) required for the propagation of feature annotation A0A1U8KK77 unreviewed LOC107916588 A0A1U8KKB9 unreviewed LOC107918005 A0A1U8KMJ7 unreviewed LOC107918597 A0A1U8KU13 unreviewed LOC107920644 A0A1U8KW43 unreviewed LOC107920212 A0A1U8KZC8 unreviewed LOC107920798 A0A1U8L2Q1 unreviewed LOC107921997 A0A1U8LDJ9 unreviewed LOC107926341 A0A1U8LQ31 unreviewed LOC107929702 A0A1U8LVB9 unreviewed LOC107930272 A0A1U8MCZ3 unreviewed LOC107935354 A0A1U8MD24 unreviewed LOC107936522 A0A1U8MSK5 unreviewed LOC107940865 A0A1U8NFC2 unreviewed LOC107947667 Lacks conserved residue(s) required for the propagation of feature annotation A0A1U8NGI4 unreviewed LOC107948209 A0A1U8NIP8 unreviewed LOC107947670 Lacks conserved residue(s) required for the propagation of feature annotation A0A1U8NQC1 unreviewed LOC107950744 A0A1U8NVY2 unreviewed LOC107951560 A0A1U8Q3B7 unreviewed LOC104596209 A0A1Y1ILQ5 unreviewed A0A1Z5S5G9 unreviewed A0A1Z5SBR2 unreviewed A0A251KGU3 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A251ND31 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251ND37 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251ND47 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251ND84 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251NKD7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251P317 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251PK63 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A251Q794 unreviewed A0A251QR74 unreviewed A0A251R2R5 unreviewed A0A251RJH6 unreviewed A0A251RYV9 unreviewed TH1 A0A251RZF0 unreviewed A0A251S0B1 unreviewed DAG A0A251SM27 unreviewed A0A251T8A8 unreviewed A0A251TVS1 unreviewed A0A251TY97 unreviewed A0A251TZN8 unreviewed UBC18 A0A251U2R1 unreviewed ATTAP1 A0A251UQE1 unreviewed A0A286YAF2 unreviewed grhl1 A0A286ZWM0 unreviewed NT5C3B A0A287A0H6 unreviewed AFF2 A0A287A9G1 unreviewed CRMP1 A0A287AE63 unreviewed NEDD8 A0A287AG10 unreviewed MLKL A0A287AGK9 unreviewed A0A287AMW5 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A287AV28 unreviewed A0A287B5U9 unreviewed PDIA2 A0A287BA45 unreviewed SUCLG2 A0A287BDY8 unreviewed LGSN A0A287BGI5 unreviewed NUDT16L1 A0A287BKG2 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation A0A2A6BEN1 unreviewed WBGene00089576 Lacks conserved residue(s) required for the propagation of feature annotation A0A2A6BN72 unreviewed WBGene00113196 A0A2A6BQW1 unreviewed WBGene00092100 A0A2A6C3V7 unreviewed WBGene00278998 Lacks conserved residue(s) required for the propagation of feature annotation A0A2A6C4Z0 unreviewed WBGene00102309 A0A2A6CPC3 unreviewed WBGene00098594 A0A2A6CQR6 unreviewed WBGene00114970 A0A2A6CRU6 unreviewed WBGene00276062 A0A2A6CUB7 unreviewed WBGene00101004 A0A2C9U4P8 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9U802 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9UGY8 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9UNG4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9UTA5 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9VWJ2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9W9I1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9WCG4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2C9WM49 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2XW82 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2Y1U3 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2YKN3 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2Z6X6 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2ZGK5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation || The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2G2ZYT6 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A2H4HHY6 reviewed A0A2I2Y3Q1 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I2YDH7 unreviewed LOC101144552 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I2YG83 unreviewed DPYSL3 A0A2I2YHY6 unreviewed A0A2I2YIC1 unreviewed AHCYL2 A0A2I2YKJ4 unreviewed CRMP1 A0A2I2YM77 unreviewed PANK4 A0A2I2YTZ0 unreviewed SUCLG2 A0A2I2YWR5 unreviewed CHPF2 A0A2I2Z061 unreviewed THNSL2 A0A2I2Z098 unreviewed DPYSL5 A0A2I2Z2I8 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A2I2Z779 unreviewed A0A2I2Z873 unreviewed RPS6KC1 A0A2I2Z978 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A2I2Z9V1 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I2ZB58 unreviewed RNASE11 A0A2I2ZI90 unreviewed GRB7 A0A2I2ZSU6 unreviewed DMRTC2 A0A2I3RIZ3 unreviewed A0A2I3RLU0 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3RPS6 unreviewed AHCYL1 A0A2I3RU26 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3S5X5 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3S725 unreviewed CHPF2 A0A2I3S7C7 unreviewed PTPN20 A0A2I3SDT2 unreviewed AHCYL2 A0A2I3SN54 unreviewed FRMD7 A0A2I3SPY6 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3SQ35 unreviewed SUCLG2 A0A2I3T077 unreviewed PADI6 A0A2I3T0N5 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3T6A7 unreviewed A0A2I3TG97 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation A0A2I3TMQ9 unreviewed NEDD8 A0A2I3TU27 unreviewed A0A2I3TVA3 unreviewed A0A2I3TVF9 unreviewed STK19 A0A2I4DM08 unreviewed LOC108981464 A0A2I4EP61 unreviewed LOC108991400 A0A2I4ERM3 unreviewed LOC108992052 A0A2I4EUU3 unreviewed LOC108992903 A0A2I4EUV7 unreviewed LOC108992903 A0A2I4F643 unreviewed LOC108995902 A0A2I4FCC5 unreviewed LOC108997453 A0A2I4FGS9 unreviewed LOC108998660 A0A2I4G8K7 unreviewed LOC109005666 A0A2I4GCJ6 unreviewed LOC109006669 A0A2I4GDQ3 unreviewed LOC109007012 A0A2I4HUL8 unreviewed LOC109021645 A0A2I4HUR2 unreviewed LOC109021645 A0A2J8JC45 unreviewed AZIN2 A0A2J8JHL6 unreviewed RNASE9 A0A2J8NK93 unreviewed CYFIP2 A0A2J8PJU5 unreviewed RPS6KL1 A0A2J8QU64 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A2K1IGM7 unreviewed A0A2K1III0 unreviewed LOC112275571 A0A2K1IM81 unreviewed LOC112274692 A0A2K1IQ72 unreviewed LOC112274406 A0A2K1JU79 unreviewed A0A2K1YLT4 unreviewed A0A2K1YNW5 unreviewed A0A2K1Z947 unreviewed A0A2K2AKU4 unreviewed A0A2K2B015 unreviewed A0A2K3CXY0 unreviewed A0A2K3DL54 unreviewed A0A2K5TIX5 unreviewed RNASE9 A0A2K5VFW3 unreviewed A0A2L2DDD0 reviewed A0A2L2DDE6 reviewed A0A2R6W299 unreviewed A0A2R6WNN2 unreviewed A0A2R6X092 unreviewed A0A2R6XBU9 unreviewed A0A2R6XDQ8 unreviewed A0A2R6XMB1 unreviewed A0A2R8Q421 unreviewed csnk1a1 A0A2R8QT05 unreviewed gata1a A0A2R9YJQ0 unreviewed apex1 A0A2U2GW53 unreviewed A0A2U8U0I3 unreviewed PGRP-LC A0A2U8U141 unreviewed PGRP-LC A0A2U8U1P3 unreviewed Cyp9f3 A0A385MIS5 reviewed Chi Chi has substitutions in residues that are highly conserved in GH18 chitinases (E167Q and M238L) that form an interface in the catalytic pocket where the cleavage of the substrate occurs and is, therefore, enzymatically inactive A0A396JG59 reviewed EX70I A0A397ZBP6 unreviewed A0A398AHL5 unreviewed A0A398ALS2 unreviewed A0A3B3H5Y1 unreviewed jarid2b Lacks conserved residue(s) required for the propagation of feature annotation A0A3B3H7L6 unreviewed A0A3B3HER5 unreviewed rhbdf1a A0A3B3HHD5 unreviewed LOC101166279 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B3HHX5 unreviewed suclg2 A0A3B3HMC2 unreviewed crmp1 A0A3B3HV08 unreviewed chpfa A0A3B3HWD1 unreviewed RHBDF2 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B3ICP8 unreviewed dpysl2b A0A3B3ICU2 unreviewed cercam A0A3B3ILC6 unreviewed thnsl2 A0A3B3IMS5 unreviewed nrbp1 A0A3B3IPE6 unreviewed A0A3B5XTE1 unreviewed LOC123184992 A0A3B5XWK9 unreviewed LOC123096523 A0A3B5YQ55 unreviewed A0A3B5YRK4 unreviewed A0A3B5YRT8 unreviewed LOC123104277 A0A3B5YST6 unreviewed LOC123087805 A0A3B5YV59 unreviewed A0A3B5ZMS0 unreviewed A0A3B5ZPP1 unreviewed LOC123165528 A0A3B5ZU53 unreviewed LOC123168627 A0A3B6EBM0 unreviewed LOC123060136 A0A3B6EMU3 unreviewed LOC123063012 A0A3B6GL92 unreviewed LOC123077142 A0A3B6H073 unreviewed LOC123080222 A0A3B6HXE4 unreviewed A0A3B6I089 unreviewed A0A3B6I158 unreviewed LOC123087233 A0A3B6I164 unreviewed LOC123087235 A0A3B6IJN2 unreviewed LOC123094283 A0A3B6IN27 unreviewed LOC123087280 A0A3B6JCD7 unreviewed LOC123099407 A0A3B6JF90 unreviewed A0A3B6K978 unreviewed LOC123106266 A0A3B6KPS5 unreviewed LOC123105615 A0A3B6KRZ5 unreviewed LOC123105989 A0A3B6NNS1 unreviewed LOC123132472 A0A3B6NT78 unreviewed LOC123130879 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6NTQ6 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6NU49 unreviewed LOC123130878 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6PJI3 unreviewed LOC123136540 A0A3B6PPL8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6PR17 unreviewed LOC123139384 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6PR36 unreviewed LOC123134438 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6QCB1 unreviewed LOC123144049 A0A3B6QH46 unreviewed LOC123141720 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6QJH9 unreviewed LOC123141718 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6QKB2 unreviewed LOC123145321 Lacks conserved residue(s) required for the propagation of feature annotation A0A3B6RDL4 unreviewed LOC123150571 A0A3B6RGV6 unreviewed LOC123147424 A0A3B6SDM1 unreviewed LOC123155488 A0A3B6SFQ6 unreviewed LOC123159787 A0A3B6SG14 unreviewed A0A3B6SHI1 unreviewed A0A3B6TFM1 unreviewed LOC123167472 A0A3B6TPT2 unreviewed LOC123165060 A0A3B6UBS5 unreviewed A0A3L6EVD3 unreviewed ZmHK3b A0A3P5YKS1 unreviewed A0A3Q0KDV9 reviewed SEPT10 A0A3Q0NBH7 reviewed pgdA A0A3Q1LW97 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A3Q1LXY5 unreviewed DPYSL3 A0A3Q1M1G9 unreviewed AZIN2 A0A3Q1M4R4 unreviewed RNASE12 A0A3Q1NM83 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation A0A3Q2GUL4 unreviewed AFF2 A0A3Q2H1G8 unreviewed A0A3Q2H8B0 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A3Q2HED3 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A3Q2HSV9 unreviewed ERP27 A0A3Q2HT50 unreviewed AHCYL2 A0A3Q2I5S9 unreviewed RPS6KC1 A0A3Q2IAT7 unreviewed DMRTC2 A0A3Q2ICT0 unreviewed A0A3Q2KLA4 unreviewed PGM5 A0A3Q2L9A9 unreviewed CRMP1 A0A3Q2LCZ6 unreviewed AHCYL1 A0A3Q2LG11 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A3Q2LGG3 unreviewed DPYSL5 A0A3Q7EQD0 unreviewed A0A3Q7F4J8 unreviewed LOC101245223 A0A3Q7F6N8 unreviewed LOC101267671 A0A3Q7FFM8 unreviewed LOC101259914 A0A3Q7G1V2 unreviewed A0A3Q7G232 unreviewed LOC101266392 A0A3Q7GSD3 unreviewed LOC101268188 A0A3Q7I9N5 unreviewed A0A3Q7IIH8 unreviewed A0A3Q7JC23 unreviewed ABCB29 A0A453Z012 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A480IH47 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation A0A480J9D5 unreviewed DPYSL3 A0A480URP4 unreviewed DPYSL4 A0A4D6K026 unreviewed Gucy2d A0A4X1TC65 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation A0A4X1UWN5 unreviewed RNASE9 A0A4X1VC81 unreviewed DPYSL2 A0A4Z3 reviewed A3galt2 A0A5F5PED9 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F5PJA1 unreviewed A0A5F5PJV5 unreviewed A0A5F5PK62 unreviewed FRMD7 A0A5F5PYC9 unreviewed PTPN20 A0A5F7ZJJ5 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F7ZMS5 unreviewed DMRTC1B A0A5F7ZS03 unreviewed LOC705256 A0A5F7ZVA6 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F8A7H8 unreviewed LOC717531 A0A5F8A8F6 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F8G5N3 unreviewed NUDT16L1 A0A5F8G6E0 unreviewed FRMD7 A0A5F8GAQ4 unreviewed A0A5F8GBU6 unreviewed PM20D2 A0A5F8GEI9 unreviewed GRB7 A0A5F8GFW9 unreviewed AHCYL1 A0A5F8GG53 unreviewed LOC100032457 A0A5F8GKP1 unreviewed RPS6KC1 A0A5F8GLD5 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F8GT34 unreviewed DPYSL3 A0A5F8GVB2 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation A0A5F8GWM2 unreviewed KCNU1 A0A5F8H9R2 unreviewed AFF2 A0A5F8HF28 unreviewed A0A5F8MPH8 unreviewed Tnxb Lacks conserved residue(s) required for the propagation of feature annotation A0A5G2Q8T1 unreviewed A0A5G2R934 unreviewed AHCYL2 A0A5G2RJ33 unreviewed NEK4 A0A5H1ZRJ2 unreviewed ctnnb1 A0A6A4NPZ7 reviewed Displayed sequence for cv. Amiga (pauper allele) is inactive, an active tetrahydroanabasine acetyltransferase sequence is available for cv. Graecus and cv. P27174 (AC P0DO65) A0A6G9KHD3 reviewed A0A6I8N2S4 unreviewed CERCAM A0A6I8N475 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8N516 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8NAU0 unreviewed GPD1L A0A6I8NCS9 unreviewed NEDD8 A0A6I8NEA0 unreviewed AHCYL2 A0A6I8NI59 unreviewed PM20D2 A0A6I8NKG8 unreviewed NRBP1 A0A6I8NPI1 unreviewed SUCLG2 A0A6I8NQ92 unreviewed LOC114805750 A0A6I8NQF0 unreviewed RHBDF1 A0A6I8NVR0 unreviewed PDIA2 A0A6I8P2K4 unreviewed NT5C3B A0A6I8P9Z1 unreviewed WHR1 A0A6I8PA93 unreviewed RPS6KL1 A0A6I8PC62 unreviewed PGM5 A0A6I8PCP8 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8PD30 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8PH71 unreviewed AHCYL1 A0A6I8PQQ9 unreviewed DPYSL2 A0A6I8PRK6 unreviewed TINCR Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8QC40 unreviewed pgm5 A0A6I8R680 unreviewed hgf Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8RBI5 unreviewed grb7 A0A6I8RQP3 unreviewed ror1 Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8SCP3 unreviewed aebp1 Lacks conserved residue(s) required for the propagation of feature annotation A0A6I8SZG6 unreviewed cercam A0A6L8PK77 unreviewed gapN A0A6M3Q8Y2 unreviewed bma A0A6M3QH83 unreviewed Dmel\CG12869 A0A6P9DTF3 unreviewed LOC108992031 A0A6P9E9M1 unreviewed LOC108989349 A0A7I4BPQ6 unreviewed LOC112272645 A0A7I4FCB2 unreviewed LOC112291515 A0A7J6KBZ0 reviewed DPA Likely diverged to the point of losing deoxyribose-phosphate aldolase enzymatic activity (PubMed:25284756). The residues implicated in substrate binding and the key catalytic residue are not conserved compared to catalytically active deoxyribose-phosphate aldolases (PubMed:25284756). No activity was observed in the assays using 2-deoxy-D-ribose 5-phosphate as substrate (PubMed:25284756) A0A7M7GG21 unreviewed A0A7M7GJX8 unreviewed A0A7M7GP58 unreviewed A0A7M7HCH3 unreviewed A0A7M7HKY6 unreviewed A0A7M7HML4 unreviewed A0A7M7LLK3 unreviewed A0A7M7N459 unreviewed A0A7M7N4I4 unreviewed A0A7M7N5J5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A7M7NFE6 unreviewed A0A7M7NL51 unreviewed A0A7M7NLJ9 unreviewed A0A7M7NP17 unreviewed A0A7M7NRJ3 unreviewed A0A7M7NT40 unreviewed A0A7M7NTQ7 unreviewed A0A7M7NWI0 unreviewed A0A7M7NZU3 unreviewed A0A7M7PV25 unreviewed A0A7M7RB40 unreviewed A0A7M7RDD7 unreviewed A0A7M7RG15 unreviewed A0A7M7RG37 unreviewed A0A7M7RG81 unreviewed A0A7M7RGV3 unreviewed A0A7M7RGW9 unreviewed A0A7M7SSG7 unreviewed A0A7M7SXD4 unreviewed A0A7M7SXF1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A7M7SY45 unreviewed A0A7M7SYD7 unreviewed A0A7M7SZS5 unreviewed A0A7M7T504 unreviewed A0A7M7TG50 unreviewed A0A7M7THH7 unreviewed A0A7U9P668 reviewed A0A803J736 unreviewed rps6kl1 A0A803K2L5 unreviewed chpf A0A803SL14 unreviewed nedd8 A0A803SLK5 unreviewed MLKL A0A803SM71 unreviewed pdia2 Lacks conserved residue(s) required for the propagation of feature annotation A0A803SNM0 unreviewed MCOLN2 A0A803SSR0 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation A0A803SV97 unreviewed SUCLG2 Lacks conserved residue(s) required for the propagation of feature annotation A0A803SXD7 unreviewed CRMP1 A0A803SXZ1 unreviewed DPYSL2 A0A803T605 unreviewed AHCYL2 A0A803TXU2 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A803TY90 unreviewed DPYSL3 A0A803TZA5 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A804IKX7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A804IUL1 unreviewed A0A804J2W6 unreviewed A0A804J6P5 unreviewed A0A804JG55 unreviewed A0A804JMI6 unreviewed A0A804K8N6 unreviewed A0A804KDA0 unreviewed A0A804KDP1 unreviewed A0A804KI34 unreviewed A0A804KI61 unreviewed A0A804KIN1 unreviewed A0A804KNS2 unreviewed A0A804LCG6 unreviewed LOC103630932 A0A804N8U6 unreviewed LOC103650860 A0A804P934 unreviewed LOC100282569 A0A804QPR4 unreviewed LOC103635660 A0A804R1H2 unreviewed LOC100193134 A0A834RHI5 reviewed Although it belongs to the peptidase S1 family, lacks the active site residues and has no protease activity A0A8D0R9P0 unreviewed GPD1L A0A8D0U1I9 unreviewed DMRTC2 A0A8I3MH06 unreviewed DMRTC2 A0A8I3MHV6 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3MIQ5 unreviewed RPS6KC1 A0A8I3MKB3 unreviewed CYFIP2 A0A8I3MLT2 unreviewed PADI6 A0A8I3MMP3 unreviewed CRMP1 A0A8I3MPB6 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3MPS0 unreviewed PGM5 A0A8I3MSA8 unreviewed AZIN2 A0A8I3MYU1 unreviewed MCOLN2 A0A8I3N2C0 unreviewed NEDD8 A0A8I3N3F7 unreviewed PM20D2 A0A8I3NCZ1 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3NFE3 unreviewed NT5C3B A0A8I3NGD4 unreviewed CHPF2 A0A8I3NGT3 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3NID0 unreviewed GRB7 A0A8I3NN53 unreviewed THNSL2 A0A8I3NP20 unreviewed DPYSL2 A0A8I3NRF2 unreviewed KCNU1 A0A8I3NS78 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3NUW1 unreviewed RPS6KL1 A0A8I3P2Z0 unreviewed RHBDF2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3P920 unreviewed NUDT16L1 A0A8I3PB41 unreviewed ERP27 A0A8I3PCZ1 unreviewed PANK4 A0A8I3PF17 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3PFJ6 unreviewed DPYSL3 A0A8I3PGJ9 unreviewed AFF2 A0A8I3PJW4 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3PM53 unreviewed RNASE10 A0A8I3PN98 unreviewed GPD1L A0A8I3PQK9 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3PUK2 unreviewed TRIM59 A0A8I3Q0M1 unreviewed FAM20A A0A8I3Q2W0 unreviewed SNX15 A0A8I3Q2X2 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3Q5S7 unreviewed PASD1 A0A8I3Q6I3 unreviewed CHPF A0A8I3Q844 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3Q9C8 unreviewed LOC491957 A0A8I3QDS8 unreviewed FRMD7 A0A8I3QGG9 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3QQS7 unreviewed CERCAM A0A8I3QQT9 unreviewed PDIA2 A0A8I3QZJ2 unreviewed PTPN20 A0A8I3RU48 unreviewed NRBP1 A0A8I3RYH0 unreviewed SUCLG2 A0A8I3RZ66 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I3S4H8 unreviewed AHCYL2 A0A8I3S6M1 unreviewed RNASE12 A0A8I3S7T3 unreviewed DPYSL4 A0A8I3S8H2 unreviewed RNASE13 A0A8I3SC06 unreviewed DPYSL5 A0A8I5XWT5 unreviewed Sirt3 A0A8I5Y4Y3 unreviewed Tenm3 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5Y5Z6 unreviewed Xrcc4 A0A8I5Y7L4 unreviewed Top2b A0A8I5Y871 unreviewed Ago1 A0A8I5Y8H6 unreviewed Psd3 A0A8I5YBE4 unreviewed Pkp3 A0A8I5YBY9 unreviewed Pcmtd1 A0A8I5YC36 unreviewed Ranbp2 A0A8I5ZJ96 unreviewed Whr1 A0A8I5ZJD4 unreviewed Zic5 A0A8I5ZKA9 unreviewed Abcd4 A0A8I5ZKP8 unreviewed Gpd1l2 A0A8I5ZLK5 unreviewed Abca1 A0A8I5ZLP4 unreviewed Inpp5f A0A8I5ZM01 unreviewed Evi5 A0A8I5ZMM4 unreviewed Cyp11b2 A0A8I5ZMX5 unreviewed Tbc1d1 A0A8I5ZNA1 unreviewed Ano4 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZNM6 unreviewed Crtam Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZNW7 unreviewed Ano1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZNY7 unreviewed Exosc7 A0A8I5ZPR7 unreviewed Wiz A0A8I5ZPV1 unreviewed Tbc1d22a A0A8I5ZQ92 unreviewed Hnrnpr A0A8I5ZQD4 unreviewed Dst A0A8I5ZQX3 unreviewed Ror1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZQY6 unreviewed Sox4 A0A8I5ZRB2 unreviewed Atxn2 A0A8I5ZRZ8 unreviewed Mfhas1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZSJ6 unreviewed Arih1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I5ZTN5 unreviewed Adsl A0A8I5ZTV6 unreviewed Sar1a A0A8I5ZUT2 unreviewed Irgq A0A8I5ZUW5 unreviewed Pcm1 A0A8I5ZV82 unreviewed Mlkl A0A8I5ZWC2 unreviewed Myo6 A0A8I5ZWP3 unreviewed Itgax A0A8I5ZX53 unreviewed Surf4 A0A8I6A0T0 unreviewed Pdia2 A0A8I6A123 unreviewed Ecpas A0A8I6A182 unreviewed Pitpnc1 A0A8I6A1Z3 unreviewed Zfp683 A0A8I6A2A6 unreviewed Afg2a A0A8I6A2P1 unreviewed Srsf3 A0A8I6A320 unreviewed Nudt16l1 A0A8I6A378 unreviewed Eif4g3 A0A8I6A3U5 unreviewed Dnajb2 A0A8I6A4C8 unreviewed Frat1 A0A8I6A4L6 unreviewed Tbc1d15 A0A8I6A504 unreviewed Zfc3h1 A0A8I6A5F2 unreviewed Sun1 A0A8I6A5G9 unreviewed Gm2a A0A8I6A7M0 unreviewed Taf1 A0A8I6A7U0 unreviewed Fkbp15 A0A8I6AA94 unreviewed Ano6 A0A8I6ABJ9 unreviewed Ythdf2 A0A8I6ACC2 unreviewed Ythdf3 A0A8I6ACC7 unreviewed Rbm7 A0A8I6AD01 unreviewed Rps6kl1 A0A8I6AD67 unreviewed Parp9 A0A8I6ADK8 unreviewed Rapgef6 A0A8I6AF72 unreviewed Mecom A0A8I6AI80 unreviewed Trim24 A0A8I6AIH6 unreviewed Suclg2 A0A8I6AJ01 unreviewed Gpat4 A0A8I6AJ44 unreviewed Tnxb Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6AJC4 unreviewed Ano5 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6ALB6 unreviewed Tbc1d2b A0A8I6ALM9 unreviewed Ptk7 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6ALR9 unreviewed Tmem65 A0A8I6ALX9 unreviewed Gpd1l3 A0A8I6AM39 unreviewed Bmpr2 A0A8I6AMJ4 unreviewed Syt14 A0A8I6AN52 unreviewed Hpse2 A0A8I6ANL3 unreviewed Shisa7 A0A8I6AP95 unreviewed Lmo3 A0A8I6APP5 unreviewed Sirt6 A0A8I6AQ75 unreviewed Chmp6 A0A8I6AS02 unreviewed Pacsin3 A0A8I6ASP1 unreviewed Kmt2e Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6ATK2 unreviewed Itga3 A0A8I6AVN8 unreviewed Slc2a9 A0A8I6AVQ3 unreviewed Eif5 A0A8I6AXS5 unreviewed Rabgap1l A0A8I6B3N3 unreviewed Atp6v1g1 A0A8I6G2K8 reviewed Kdm1a Conflicting results exist regarding the H3K4 demethylase activity of the neuron-specific isoforms (LSD1+8a). One study reports that this isoform retains H3K4 demethylase activity. In contrast, an other study argues that the neuron-specific isoform is reprogrammed (via cofactors such as SVIL and others) to preferentially target H3K9me2, showing little to no H3K4me1/2 demethylase activity. The discrepancies appear to come from differences in assay type, complex composition, substrates (peptides vs nucleosomes), cofactors, post-translational states A0A8I6G4Y3 unreviewed Ddx5 A0A8I6G984 unreviewed Lcp1 A0A8I6GA90 unreviewed Hip1 A0A8I6GAD6 unreviewed Nrbp1 A0A8I6GB32 unreviewed Bcl9 A0A8I6GCQ3 unreviewed Ano8 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6GDA0 unreviewed Nrbp1 A0A8I6GF11 unreviewed Eif4a1-ps8 A0A8I6GFX3 unreviewed Tut4 A0A8I6GGP5 unreviewed Ano9 A0A8I6GHQ8 unreviewed Exosc5 A0A8I6GHX2 unreviewed Cox7a2l A0A8I6GIL4 unreviewed Tmem87a A0A8I6GKM7 unreviewed LOC120099304 A0A8I6GL24 unreviewed Aida A0A8I6GLF2 unreviewed Mief2 A0A8I6GM68 reviewed Hdac6 Was originally thought to be a histone deacetylase. However, subsequent work has shown that it is predominantly cytoplasmic and deacetylates a range of non-histone substrates A0A8I6X606 unreviewed LOC123445168 A0A8I6XIP3 unreviewed LOC123449906 A0A8I6Y012 unreviewed LOC123403434 A0A8I6YDR5 unreviewed A0A8I6YEX4 unreviewed LOC123405273 Lacks conserved residue(s) required for the propagation of feature annotation A0A8I6YLH5 unreviewed LOC123412722 A0A8I6YR21 unreviewed A0A8J0Q351 unreviewed crmp1.L A0A8J0QCR3 unreviewed pank4 A0A8J0QJD1 unreviewed jarid2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8J0QK14 unreviewed mcoln2 A0A8J0SL80 unreviewed whr1 A0A8J0SYR8 unreviewed ryk Lacks conserved residue(s) required for the propagation of feature annotation A0A8J0T1W0 unreviewed sema7a Lacks conserved residue(s) required for the propagation of feature annotation A0A8J0TR01 unreviewed fam20a.S A0A8J0TZJ2 unreviewed LOC108701821 A0A8J0U134 unreviewed rhbdf1.S Lacks conserved residue(s) required for the propagation of feature annotation A0A8J0U447 unreviewed LOC108704485 A0A8J0UMQ7 unreviewed ahcyl2.S A0A8J0UNM6 unreviewed ahcyl2.L A0A8J0UNT9 unreviewed dpysl3.L A0A8J0VDM1 unreviewed ryk.S Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1IPB3 unreviewed adamtsl2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1IX95 unreviewed fam20a.2 A0A8J1JL30 unreviewed lgsn A0A8J1JSM5 unreviewed dpysl4 A0A8J1KL80 unreviewed nrbp1.L A0A8J1KP47 unreviewed lgsn.L A0A8J1KQK4 unreviewed dpysl5.L A0A8J1KUZ5 unreviewed pm20d2.S A0A8J1KWF3 unreviewed nrbp1.S A0A8J1L2C7 unreviewed jarid2.S Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1L4R1 unreviewed dpysl4.L A0A8J1L6U0 unreviewed pank4.L A0A8J1LNK4 unreviewed LOC108699897 Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1LPK7 unreviewed nt5c3b.L A0A8J1LR72 unreviewed rhbdf2.L A0A8J1LTM3 unreviewed grb7.L A0A8J1LUI3 unreviewed rhbdf1.L Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1M2E7 unreviewed grb7.S A0A8J1MNJ1 unreviewed LOC108711304 Lacks conserved residue(s) required for the propagation of feature annotation A0A8J1MRG8 unreviewed LOC108712711 A0A8J1MWD7 unreviewed LOC108714144 A0A8J1MZ45 unreviewed mst1.S Lacks conserved residue(s) required for the propagation of feature annotation A0A8J8XAX4 unreviewed Oas1d A0A8J8XB91 unreviewed Trib2 A0A8J8XBZ3 unreviewed Parp3 A0A8J8XYU9 unreviewed Myo7a A0A8J8YBF1 unreviewed Slc30a6 A0A8J8YN55 unreviewed Ing4 A0A8L2UMZ7 unreviewed Surf4 A0A8M1P4R1 unreviewed pank4 A0A8M1P554 unreviewed apex1 A0A8M1PAH1 unreviewed apex1 A0A8M1QUN4 unreviewed kcnh3 A0A8M1RM42 unreviewed dpysl2a A0A8M1RN50 unreviewed grb7 A0A8M2B1U6 unreviewed dpysl2b A0A8M2B2A7 unreviewed spast Lacks conserved residue(s) required for the propagation of feature annotation A0A8M2B701 unreviewed crmp1 A0A8M2BAC5 unreviewed hsd17b2 A0A8M2BBI4 unreviewed rhbdf1a Lacks conserved residue(s) required for the propagation of feature annotation A0A8M2BCL0 unreviewed isl1a A0A8M2BDC2 unreviewed boka A0A8M2BE31 unreviewed cdc14b A0A8M2BE48 unreviewed cdc14b A0A8M2BE70 unreviewed cdc14b A0A8M2BFL7 unreviewed cacna1sa A0A8M2BIG2 unreviewed ahcyl2a A0A8M2BJH3 unreviewed mta2 A0A8M2BK13 unreviewed robo4 Lacks conserved residue(s) required for the propagation of feature annotation A0A8M3AMN1 unreviewed cry4 A0A8M3AXB8 unreviewed gata2a A0A8M3B2Q8 unreviewed wnt11f2 A0A8M6Z121 unreviewed ctnnb1 A0A8M6Z942 unreviewed trpa1a A0A8M9PV58 unreviewed rdh8a A0A8M9Q2R3 unreviewed tbx5b Lacks conserved residue(s) required for the propagation of feature annotation A0A8M9Q709 unreviewed gata2a A0A8M9Q8F2 unreviewed dpysl4 A0A8M9QDI3 unreviewed tbx5a Lacks conserved residue(s) required for the propagation of feature annotation A0A8N7V082 unreviewed pard3ab A0A8V0X2P1 unreviewed LGSN A0A8V0X2Q2 unreviewed DPYSL4 A0A8V0XJ62 unreviewed PM20D2 A0A8V0XL51 unreviewed NEDD8 A0A8V0XM30 unreviewed AHCYL2 A0A8V0XPH6 unreviewed RPS6KL1 A0A8V0XXL4 unreviewed LOC107053190 A0A8V0XZM9 unreviewed NRBP1 A0A8V0Y9C1 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation A0A8V0YBP9 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V0YCN8 unreviewed A0A8V0YG28 unreviewed LOC107048995 A0A8V0YJR4 unreviewed PGM5 A0A8V0YQZ5 unreviewed NUDT16L1 A0A8V0YW92 unreviewed AZIN2 A0A8V0YWS1 unreviewed THNSL2 A0A8V0Z1J8 unreviewed FRMD7 A0A8V0Z4N5 unreviewed PANK4 A0A8V0Z8T4 unreviewed RPS6KC1 A0A8V0Z8Z8 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V0ZA46 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V0ZAI4 unreviewed KCNU1 A0A8V0ZC44 unreviewed CHPF A0A8V0ZM58 unreviewed MCOLN2 A0A8V0ZPB2 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation A0A8V0ZSF8 unreviewed NT5C3B A0A8V0ZY40 unreviewed GRB7 A0A8V1A1G5 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V1A1S6 unreviewed AHCYL1 A0A8V1A3G7 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A8V1A3H9 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V1AAG2 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation A0A8V1ACT6 unreviewed FAM20A A0A8V1AHF9 unreviewed CERCAM A0A8V1AK23 unreviewed RHBDF2 A0A8W4F976 unreviewed KCNU1 A0A8W4FCJ5 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation A0A8W4FHQ7 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation A0A903WTW0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A9J7HVA2 unreviewed LOC118409151 A0A9J7L0L0 unreviewed LOC118414145 A0A9J7L462 unreviewed LOC118415242 A0A9J7LBL3 unreviewed LOC118418092 A0A9J7LC02 unreviewed LOC118418186 Lacks conserved residue(s) required for the propagation of feature annotation A0A9J7LMI6 unreviewed LOC118422248 A0A9J7LN88 unreviewed LOC118422506 A0A9J7LNT1 unreviewed LOC118422704 A0A9J7M2K4 unreviewed LOC118427308 A0A9J7MB81 unreviewed LOC118429588 A0A9J7MG03 unreviewed LOC118431956 A0A9J7MSR8 unreviewed LOC118417962 A0A9J7MSS9 unreviewed LOC118416520 A0A9J7MV75 unreviewed LOC118418178 A0A9J7MX34 unreviewed LOC118420446 A0A9J7N270 unreviewed LOC118422951 A0A9J7N7C6 unreviewed LOC118427190 Lacks conserved residue(s) required for the propagation of feature annotation A0A9K3H8E2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9K3I6I4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9L0R649 unreviewed NT5C3B A0A9L0RNY7 unreviewed A0A9L0RPK7 unreviewed A0A9L0RUY9 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A9L0RW41 unreviewed A0A9L0RWY9 unreviewed A0A9L0RZE8 unreviewed A0A9L0S817 unreviewed RNASE9 A0A9L0S9Z6 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation A0A9L0SA83 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0A9L0SDR7 unreviewed SUCLG2 A0A9L0SJT8 unreviewed NEDD8 A0A9L0SPS8 unreviewed A0A9L0TB13 unreviewed A0A9L0TFA7 unreviewed GPD1L A0A9R0IKQ5 unreviewed LOC110790575 A0A9R0IQE4 unreviewed LOC110792882 A0A9R0IQF7 unreviewed LOC110793153 A0A9R0IQM4 unreviewed LOC110792885 A0A9R0JPK0 unreviewed LOC110782444 A0A9R0JTX7 unreviewed LOC110786641 A0A9R0K252 unreviewed LOC110794340 A0A9R0K5U6 unreviewed LOC110798722 A0A9R0K5Y5 unreviewed LOC110798103 A0A9R0K6R4 unreviewed LOC110798889 A0A9R1UNL1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1UYH9 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1V0U0 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1VMY5 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1VT81 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1W7V7 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1WA02 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1WCB4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1WMD1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1WXQ1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1X089 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1X0H6 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1X0R6 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1X1Y7 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0A9R1XMX4 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A0AB13A9K4 unreviewed pard3ab A0AB13A9V8 unreviewed ahr1a A0AB32T4Z2 unreviewed ahr1a A0AB32T9S9 unreviewed hoxa3a A0AB32TCE9 unreviewed ehd3 Lacks conserved residue(s) required for the propagation of feature annotation A0AB32THW0 unreviewed cry4 A0AB32TKP2 unreviewed hsd17b2 A0AB32TP54 unreviewed eif4e1b A0AB32TUH1 unreviewed cdc14b A0AB32TWA8 unreviewed cdh1 A0AB32TWQ1 unreviewed gata1a A0AB32TYC4 unreviewed cdc14b A0AB32TYW9 unreviewed fgf8a A0AB32U358 unreviewed gata2a A0ABK0KWT6 unreviewed Pin1 A0ABK0L0P7 unreviewed Plk5 A0ABK0L391 unreviewed Ehmt2 A0ABK0L5P8 unreviewed Tbc1d10a A0ABK0L600 unreviewed Fgf22 A0ABK0L6U0 unreviewed RT1-CE16 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0L6V2 unreviewed Mvb12b A0ABK0L7P8 unreviewed Recql4 A0ABK0L7Q1 unreviewed Hdac9 A0ABK0L7Q4 unreviewed Atl2 A0ABK0L7Y1 unreviewed Wbp2nl A0ABK0L854 unreviewed Mael A0ABK0L947 unreviewed Slc9b2 A0ABK0L9J7 unreviewed Chodl Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0L9L6 unreviewed Ubash3a A0ABK0L9X6 unreviewed Smap1 A0ABK0L9Z6 unreviewed Ppil2 A0ABK0LBE2 unreviewed Sat2 A0ABK0LCH6 unreviewed Baiap3 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LDA6 unreviewed Dnaaf5 A0ABK0LDI8 unreviewed Dpf2 A0ABK0LDY4 unreviewed Braf A0ABK0LE79 unreviewed Ano10 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LEA5 unreviewed Uspl1 A0ABK0LED6 unreviewed Lyplal1 A0ABK0LER1 unreviewed Msh3 A0ABK0LEW3 unreviewed Ryk Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LEZ3 unreviewed Ddx11 A0ABK0LF07 unreviewed Pcif1 A0ABK0LGH0 unreviewed Tinf2 A0ABK0LGL1 unreviewed Eif5b A0ABK0LGP3 unreviewed Eng A0ABK0LGP6 unreviewed Jade2 A0ABK0LIQ2 unreviewed Cilp Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LIZ0 unreviewed Sppl3 A0ABK0LJW1 unreviewed Tesc A0ABK0LKL1 unreviewed Acp1 A0ABK0LLE0 unreviewed Prtfdc1 A0ABK0LM55 unreviewed Gpr35 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LM84 unreviewed Serpinb6a A0ABK0LND5 unreviewed Ctns A0ABK0LNT8 unreviewed Fxr1 A0ABK0LNU5 unreviewed Dppa3 A0ABK0LNX9 unreviewed Gla A0ABK0LP46 unreviewed Tbx1 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LPA2 unreviewed Zranb3 A0ABK0LPC4 unreviewed Tmem63a A0ABK0LPG5 unreviewed Slc2a6 A0ABK0LQM7 unreviewed Gpihbp1 A0ABK0LS77 unreviewed Ccdc66 A0ABK0LSF8 unreviewed Hacd2 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LSR0 unreviewed Bag2 A0ABK0LTJ9 unreviewed Neu4 A0ABK0LTW9 unreviewed Smc5 A0ABK0LUN9 unreviewed Pld4 A0ABK0LVZ9 unreviewed Lacc1 A0ABK0LWL3 unreviewed Endou A0ABK0LWR1 unreviewed Ccnt1 A0ABK0LXA1 unreviewed Msrb3 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LXN3 unreviewed Ptpn22 A0ABK0LXQ3 unreviewed Inhca Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0LXW3 unreviewed Pls1 A0ABK0LXX0 unreviewed Dact1 A0ABK0LXY1 unreviewed Spred3 A0ABK0M1A9 unreviewed Hinfp A0ABK0M486 unreviewed Slc25a19l1 A0ABK0M4W7 unreviewed Nfib A0ABK0M5C7 unreviewed Dicer1 A0ABK0M5Z8 unreviewed Nudt15 A0ABK0M7U0 unreviewed Cpxm2 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0M8H5 unreviewed Jarid2 Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0M8H9 unreviewed Tirap Lacks conserved residue(s) required for the propagation of feature annotation A0ABK0M8N4 unreviewed Hipk2 A0ABK0M8N8 unreviewed Ikbke A0ABK0M8P3 unreviewed Prmt8 A0ABK0M9Y3 unreviewed Zfp397 A0ABZ3NN82 unreviewed Tbc1d20 A0ABZ3NNA5 unreviewed Gata5 A0ABZ3NNR6 unreviewed Cyp11b3 A0AC58G053 unreviewed badb A0AC58G6F4 unreviewed cdc14b A0AC58G6F7 unreviewed cdc14b A0AC58GGN5 unreviewed kcnh3 A0AC58GHV8 unreviewed itga4 A0AC58GHW0 unreviewed itga4 A0AC58GPC8 unreviewed gata1a A0AC58GR82 unreviewed trpa1a A0AC58GR91 unreviewed trpa1a A0AC58H0J9 unreviewed chuk A0AC58H4U7 unreviewed atp1a2a Lacks conserved residue(s) required for the propagation of feature annotation A0AC58H5J5 unreviewed ctnna1 A0AC58H5J6 unreviewed ctnna1 A0AC58H6I1 unreviewed lnx2b A0AC58HFA0 unreviewed ahr1a A0AC58HFA2 unreviewed ctnnb1 A0AC58HFA5 unreviewed ahr1a A0AC58HFB0 unreviewed ctnnb1 A0AC58HFB1 unreviewed ctnnb1 A0AC58HFB5 unreviewed ctnnb1 A0AC58HM60 unreviewed grhl1 A0AC58HM65 unreviewed grhl1 A0AC58HNE0 unreviewed plekhh1 A0AC58HTK3 unreviewed bida A0AC58HWE9 unreviewed spast A0AC58IPX4 unreviewed cry-dash A0AC58IQB8 unreviewed trpa1b A0AC58IUK6 unreviewed hdac10 A0AC58IUK7 unreviewed hdac10 A0AC58IUL5 unreviewed hdac10 A0AC58IV55 unreviewed hsd17b2 A0AC58IV56 unreviewed hsd17b2 A0AC58IV60 unreviewed hsd17b2 A0AC58JHA8 unreviewed tbx5a Lacks conserved residue(s) required for the propagation of feature annotation A0AC58JHB2 unreviewed tbx5a Lacks conserved residue(s) required for the propagation of feature annotation A0AC58JHU3 unreviewed p2rx2 A0ACD6B6G7 unreviewed cry4 A0ACJ1LGY0 unreviewed Ugt1a5 A0ACJ1M5B8 unreviewed Alg13l1 A0ACJ1N6R5 unreviewed Surf4 A0ACM8PXK9 unreviewed Dmel\CG5026 A0ACM8PY91 unreviewed meep A0ACM8PYE3 unreviewed Dmel\CG7573 A0ACM8Q176 unreviewed Dmel\CG40160 Lacks conserved residue(s) required for the propagation of feature annotation A0ACM8Q2A9 unreviewed Kctd13 A0ACM8Q2C1 unreviewed Pid1 A0ACM8Q2C2 unreviewed Parp4 A0ACM8Q2C4 unreviewed Surf4 A0ACM8Q2G0 unreviewed Jheh2 A0ACM8Q2G3 unreviewed Dmel\CG8298 A0ACM8Q2I6 unreviewed Slc1a4 A0ACM8Q2Q9 unreviewed Tbc1d22b A0ACM8Q3G2 unreviewed Eif2s2 A0ACM8Q570 unreviewed Galntl5 A0ACM8Q575 unreviewed Mcm7 Lacks conserved residue(s) required for the propagation of feature annotation A0ACM8Q577 unreviewed Edem2 A0ACM8Q5V3 unreviewed Rchy1 A0ACM8Q6T0 unreviewed Terf1 A0ACM8Q799 unreviewed Hnrnpr A0ACM8Q8Q4 unreviewed Jam2 Lacks conserved residue(s) required for the propagation of feature annotation A0ACM8QDB6 unreviewed Itgb1bp1 A0ACM8QDC1 unreviewed Pcgf2 A0ACM8QF28 unreviewed Tspan15 A0ACM8QF41 unreviewed Cer1 Lacks conserved residue(s) required for the propagation of feature annotation A0ACM8QFC8 unreviewed Tbc1d17 A0ACM8QFC9 unreviewed Tbc1d10c A0ACM8QFQ3 unreviewed Tbc1d19 A0ACM8QFQ5 unreviewed Alkbh4 A0ACM8QFT6 unreviewed Taf15 A0ACM8QFT7 unreviewed Mettl14 A0ACM8QGZ8 unreviewed Vil1 A0ACM8QH03 unreviewed Sestd1 A0DNW1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0E8V8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation A0JPA1 reviewed rhbdf2 A0MTA1 reviewed apex1 A0PK00 reviewed TMEM120B A0QQJ4 reviewed fgd A1A5B4 reviewed ANO9 A1CSU3 reviewed ecm14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates A1DGH9 reviewed ecm14 Lacks the conserved Glu residue in position 491 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates A1L1L3 reviewed Ptpn20 A1L314 reviewed Mpeg1 Was initially thought to facilitate killing of intravacuolar bacteria by inserting into the bacterial surface to form pores, thereby breaching the surface of phagocytosed bacteria (PubMed:30249808). These results were however not replicated in a later study (PubMed:35471730) A1XCI1 unreviewed LOX6 Lacks conserved residue(s) required for the propagation of feature annotation A1XCI5 unreviewed LOX10 Lacks conserved residue(s) required for the propagation of feature annotation A1XCI6 unreviewed LOX11 Lacks conserved residue(s) required for the propagation of feature annotation A1XGB4 reviewed PIMP1 A1YK02 reviewed Nup75 A1Z6G6 unreviewed Dmel\CG1344 A1Z6H0 unreviewed kune A1Z6I3 unreviewed Dmel\CG43366 A1Z6M2 unreviewed Debcl A1Z6V6 unreviewed Spn43Ad A1Z6Z8 unreviewed didum A1Z6Z9 unreviewed didum A1Z700 unreviewed didum A1Z758 unreviewed 143303_at A1Z771 unreviewed alpha-MPP A1Z782 unreviewed Dmel\CG8726 A1Z783 unreviewed Dmel\CG8726 A1Z787 unreviewed Dic3 A1Z7F4 unreviewed mtt A1Z7F5 unreviewed mtt A1Z7F6 unreviewed mtt A1Z7H7 unreviewed Dmel\CG8586 Lacks conserved residue(s) required for the propagation of feature annotation A1Z7H8 unreviewed Dmel\CG8738 Lacks conserved residue(s) required for the propagation of feature annotation A1Z7K9 reviewed PAN2 A1Z7L0 unreviewed BaraB A1Z7M8 unreviewed Ance-4 Lacks conserved residue(s) required for the propagation of feature annotation A1Z7S7 unreviewed Gnptab Lacks conserved residue(s) required for the propagation of feature annotation A1Z8A1 unreviewed trsn A1Z8D0 reviewed nclb A1Z8E5 unreviewed Spn47C A1Z8J7 unreviewed kappaTry Lacks conserved residue(s) required for the propagation of feature annotation A1Z8N1 reviewed Tret1 A1Z8P9 reviewed Mgtor A1Z8U0 unreviewed Prp8 Lacks conserved residue(s) required for the propagation of feature annotation A1Z910 unreviewed Nepl10 Lacks conserved residue(s) required for the propagation of feature annotation A1Z930 unreviewed Amph A1Z980 unreviewed Drl-2 Lacks conserved residue(s) required for the propagation of feature annotation A1Z9G3 reviewed S-Lap5 Although it belongs to the peptidase M17 family, lacks the active site Lys and Arg residues and zinc binding sites, suggesting it has no aminopeptidase activity A1Z9I0 unreviewed Dmel\CG6357 A1Z9T4 unreviewed Adgf-E A1ZA40 unreviewed SP41 Lacks conserved residue(s) required for the propagation of feature annotation A1ZA51 unreviewed HDC06631 Lacks conserved residue(s) required for the propagation of feature annotation A1ZA97 unreviewed Jhedup A1ZAC0 unreviewed Tsf3 Lacks conserved residue(s) required for the propagation of feature annotation A1ZAE9 unreviewed Trehl A1ZAF2 unreviewed Trehl A1ZAF3 unreviewed Trehl A1ZAL0 unreviewed l(2)k04810 Lacks conserved residue(s) required for the propagation of feature annotation A1ZAL1 unreviewed EG:EG0003.8 Lacks conserved residue(s) required for the propagation of feature annotation A1ZAL2 unreviewed BcDNA:RH62928 Lacks conserved residue(s) required for the propagation of feature annotation A1ZAU0 unreviewed BcDNA:AT08275 A1ZAW0 reviewed Dcr-2 A1ZAX0 reviewed CCHa1-R A1ZAX2 unreviewed Triap1 Lacks conserved residue(s) required for the propagation of feature annotation A1ZAX3 unreviewed Dmel\CG30109 Lacks conserved residue(s) required for the propagation of feature annotation A1ZB07 unreviewed Dmel\CG30323 Lacks conserved residue(s) required for the propagation of feature annotation A1ZB47 unreviewed CG5719 A1ZB91 reviewed Dnaaf3 A1ZBA4 unreviewed Dmel\CG10927 A1ZBA9 unreviewed Atg7 A1ZBB0 unreviewed Atg7 A1ZBB7 unreviewed edl A1ZBF2 unreviewed Jheh1 A1ZBF5 unreviewed Jheh3 A1ZBG3 unreviewed Gpxl A1ZBR2 unreviewed 18w A1ZBR5 reviewed Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity A1ZBU9 unreviewed Dmel\CG13423 A2A5N8 reviewed L3mbtl1 A2A6C4 reviewed Sppl2c A2A9I7 reviewed Dmrtb1 A2AD83 reviewed Frmd7 A2ALU4 reviewed Shroom2 A2ANU3 reviewed Syndig1 A2AQ92 reviewed Duox1 The role of the N-terminal peroxidase-like domain is unclear. The domain has been shown in one study to have peroxidase activity when expressed in E.coli. However, another study showed that the isolated domain does not bind heme and has no intrinsic peroxidase activity A2AQH1 unreviewed Cerkl A2ARI4 reviewed Lgr4 A2ECR8 unreviewed A2FB47 unreviewed A2G7G9 unreviewed A2IA89 reviewed Lacks acid phosphatase catalytic activity A2IA90 reviewed Lacks acid phosphatase catalytic activity A2IA93 reviewed Lacks acid phosphatase catalytic activity A2NTJ8 unreviewed Pira1 A2NTK1 unreviewed Pira4 Lacks conserved residue(s) required for the propagation of feature annotation A2QZA2 reviewed ecm14 Lacks the conserved Glu residue in position 487 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates A2RUB6 reviewed CCDC66 A2RUV9 reviewed Aebp1 Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity A2VDP2 reviewed PCMTD1 Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro A2VDS7 unreviewed DPYSL4 A2WLC1 reviewed CDT3 A3DHD2 reviewed A3KG59 reviewed Pm20d2 A3KGW5 reviewed Cercam A3KMX8 reviewed DCPH1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) A3KNF0 unreviewed nedd8.L A3KPF5 reviewed PDIL1-5 A3QJU3 reviewed coq8b A3QMC6 reviewed erl-1 Unlike mammalian homologs, does not play an essential role in the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-triphosphate receptors (IP3Rs) A4D1P6 reviewed WDR91 A4D1T9 reviewed PRSS37 Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Also lacks metal binding sites Glu in position 67 which is replaced by Asn, and Asn in position 69 which is replaced by Lys A4GSN8 reviewed NUA A4GXA9 reviewed EME2 A4IFD8 reviewed METTL14 A4II83 reviewed plppr1 Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved A4IIB7 unreviewed snx15 A4L7R7 reviewed Def1 A4QNU9 unreviewed gfer A4QNW6 unreviewed cerkl A4UZ63 unreviewed Spn43Ab A4V243 unreviewed Dmel\CG42637 A4VAK4 unreviewed hspb1 A4VCF2 unreviewed nrbp1 A4VCF7 unreviewed lnx2b A4WYU7 reviewed ago A4ZYQ5 reviewed Slc2a7 According to some reports, mediates transmembrane transport of glucose and fructose (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity) A5A5E1 unreviewed cyfip2 A5A6N6 reviewed EMP2 A5AEM8 unreviewed A5HE91 unreviewed Zfpm2 A5LGM7 reviewed Tret1 A5PJA1 reviewed AK6 AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species A5PJF6 reviewed HSDL1 Although related to the SDR family, lacks the conserved active Tyr residue in position 218 which is replaced by a Phe, suggesting that it may lack oxidoreductase activity A5WWC6 reviewed hsdl1 Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity A5X572 unreviewed poln A6H630 reviewed Dcph1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) A6H787 unreviewed HES5 A6IPG1 reviewed Eef1b2 A6MUS6 unreviewed A6ND01 reviewed IZUMO1R A6NGE7 reviewed URAD Could be the product of a pseudogene. In primates the genes coding for the enzymes for the degradation of uric acid were inactivated and converted to pseudogenes (PubMed:16462750) A6NHX0 reviewed CASTOR2 A6NL88 reviewed SHISA7 SHISA7 has been reported to interact with AMPAR subunit GRIA1 in heterologous conditions and in the brain (By similarity). However, it was later demonstrated that SHISA7 does not colocalize neither interact with AMPAR, but with GABA(A)R (By similarity). Therefore additional experiments are needed to understand the discrepancy for SHISA7 function A6QLP2 reviewed AHCYL2 A6QLW2 reviewed TGDS A6QNJ7 unreviewed PGM5 A6QPF8 reviewed TMEM120B A6QQ15 unreviewed NEK4 A6QQ71 reviewed FKBP6 Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity A6QQR7 unreviewed GPD1L A6QR62 unreviewed ERBB3 A6RCF5 reviewed ECM14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates A6X935 reviewed Itih4 A7EHK8 unreviewed A7EKP7 unreviewed A7EN59 unreviewed A7ESE8 unreviewed A7EUC0 reviewed ecm14 Lacks the conserved Glu residue in position 506 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates A7EVF1 unreviewed A7EX06 unreviewed A7KTC5 reviewed PT1 A7LCJ3 reviewed SIGLEC1 A7LJ97 unreviewed MIC-1 A7LJ99 unreviewed MIC-4 A7LJA0 unreviewed MIC-5 A7LJA3 unreviewed MIC-8 A7LJA5 unreviewed MIC-10 A7LJA8 unreviewed MIC-13 A7LJB0 unreviewed MIC-15 A7M7C7 reviewed Skor2 A7MB62 reviewed ACTR2 A7MB71 reviewed ATP1B4 A7MB73 reviewed CERCAM A7MCT6 reviewed Etnk2 According to PubMed:16861741, disruption of the gene causes increased prevalence of placental thrombosis, reduced litter size and increased pup mortality. No such effect was observed by PubMed:18755794. One possible explanation lies in the fact that PubMed:16861741 observed a remarkable 100% survival of control pups and 16% mortality for mutant pups, while PubMed:18755794 observed 16% mortality for both wild-type and mutant pups. According to PubMed:18755794, the construct used in PubMed:16861741 may lead to expression of a truncated transcript that might have deleterious effects A7RFH7 unreviewed A7RMG7 unreviewed A7RT88 unreviewed A7RTM4 unreviewed A7RUU6 unreviewed A7RX31 unreviewed A7S1P2 unreviewed A7S2S9 unreviewed A7S6A4 unreviewed A7SFD7 unreviewed A7SGT7 unreviewed A7SRK8 unreviewed A7SUT4 unreviewed A7SVK8 unreviewed A7T0U4 unreviewed A7T9X7 unreviewed A7U7N4 unreviewed Prnd A7UJ12 unreviewed Rs1 Lacks conserved residue(s) required for the propagation of feature annotation A7XQ02 reviewed A7XRZ1 reviewed tdiE A7YT55 unreviewed hdac6 A7YWH9 reviewed RHBDF1 A7YWM6 unreviewed RNASE13 A7YY82 unreviewed Jrk Lacks conserved residue(s) required for the propagation of feature annotation A8BER9 reviewed A8BNL2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data A8DY77 unreviewed Drep2 A8DYE2 reviewed Trpm A8DYP0 reviewed Obsc In contrast to obscurins in other species, lacks serine/threonine kinase activity as protein kinase domain 1 is catalytically inactive and protein kinase domain 2 is predicted to be inactive (PubMed:37121260). The lack of activity of protein kinase domain 1 is probably due to the presence of a glycine residue instead of an aspartate residue at position 3306 in the catalytic site pocket (PubMed:37121260) A8DYZ3 unreviewed Gyc32E A8DZ15 unreviewed Dmel\CG34171 Lacks conserved residue(s) required for the propagation of feature annotation A8E641 unreviewed DPYSL5 A8HSN7 unreviewed A8IU92 reviewed CFAP20 A8JMD5 unreviewed bma A8JQT1 unreviewed Gucy2d A8JR46 unreviewed Ire1 A8JRE8 unreviewed Dmel\CG34436 Lacks conserved residue(s) required for the propagation of feature annotation A8JRF0 unreviewed CG16918 Lacks conserved residue(s) required for the propagation of feature annotation A8JRF1 unreviewed Dmel\CG34295 A8JUP8 unreviewed CCKLR-17D1 Lacks conserved residue(s) required for the propagation of feature annotation A8JUR4 unreviewed Kap3 A8JUR5 unreviewed Kap3 A8JUW9 unreviewed ec Lacks conserved residue(s) required for the propagation of feature annotation A8KB76 unreviewed kcnk13a A8KBE6 unreviewed cyfip2 A8MS68 reviewed LPD1 A8MYU2 reviewed KCNU1 A8Q7G1 reviewed Although the two active site Asp residues are conserved, appears to lack catalytic activity in vitro. This could be due to the active site motif diverging from the canonical Asp-X-Gly-X motif (where X is Thr or Ser) to containing a Tyr residue (Asp-Ser-Gly-Tyr). Additionally, a Tyr residue positioned close to the catalytic site that is potentially involved in coordinating water molecules for nucleophilic attack is substituted to Phe (Phe-137) in this protein. Also, a Gly residue typically conserved at the tip of the protease flap to enable substrate binding is substituted to leucine (Leu-138) A8VU90 reviewed Ankle1 A8WMS0 unreviewed clpr-2 A8WMX3 unreviewed A8WN51 unreviewed sucg-1 A8WNW9 unreviewed A8WQL2 unreviewed A8WYG0 unreviewed A8X091 unreviewed A8X3C8 unreviewed mig-22 A8XEC6 unreviewed A8XEM5 unreviewed unc-15 A8XG37 unreviewed pnk-1 A8XGM9 unreviewed ned-8 A8XJR3 unreviewed lin-18 Lacks conserved residue(s) required for the propagation of feature annotation A8XK42 unreviewed hyl-2 A8XKA1 unreviewed pnk-4 A8XT01 unreviewed mnp-1 A8XVI8 unreviewed clp-9 A8XY28 unreviewed nipi-4 A8XYW3 unreviewed A8Y3X4 unreviewed rskd-1 A9CSE6 unreviewed WT1 +KTS isoform A9CSE8 unreviewed WT1 -KTS isoform A9JT54 unreviewed snx15 A9PC20 unreviewed A9PEJ2 unreviewed A9PGH5 unreviewed A9PH82 unreviewed A9QY39 reviewed SBTM3 A9QY40 reviewed SBTM1 A9REN6 unreviewed LOC112293528 A9SBW1 unreviewed LOC112282853 A9SWJ1 unreviewed LOC112277490 A9ULR9 reviewed kctd13 According to a first report, morpholino-mediated knockdown of kctd13 leads to increased brain size and cell proliferation (PubMed:22596160). However, it was later shown that deletion of kctd13 does not cause any change in brain size or cell proliferation (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that morpholinos used in the first study, may have affected off-targets A9UUN7 unreviewed A9UVA2 unreviewed A9V5D5 unreviewed A9VAB6 unreviewed A9VCQ7 unreviewed A9WJ65 unreviewed A9XTK7 unreviewed FLA2 A9XTL1 unreviewed FLA6 A9YWR6 reviewed STR2 A9ZSY2 reviewed Tret1 A9ZSY3 reviewed Tret1 B0BLW3 reviewed lgr4 B0BMZ6 reviewed Cfap119 B0BNL6 reviewed Arrdc1 B0R0B3 reviewed pgm5 B0XRS8 reviewed ecm14 Lacks the conserved Glu residue in position 490 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates B1AWC9 unreviewed Pde4b B1AYB6 reviewed Mbd5 B1H312 unreviewed fam20a B1NHU2 unreviewed B1NHU4 unreviewed B1NHU5 unreviewed B1PBW0 unreviewed B1PBW2 unreviewed B1PBW3 unreviewed B1PBW6 unreviewed B1WBW6 unreviewed Mfsd2a B1WC40 reviewed Ncbp2 B1WC57 unreviewed Ift25 B1WC73 unreviewed Arl6 B2DD29 reviewed Brsk1 B2GUD4 unreviewed dpysl2 B2GUT4 reviewed wnt11 B2GUV6 unreviewed Sesn2 B2GUV7 reviewed Eif5b B2GV36 reviewed Slc22a13 In contrast with human ortholog, not able to transport urate and orotate (PubMed:35144162) B2GV41 unreviewed Usp39 Lacks conserved residue(s) required for the propagation of feature annotation B2MVM5 reviewed cclA B2RX14 reviewed Tut4 B2RYE5 reviewed Epb41l4b B2RYG0 unreviewed Coro1c B2RYI0 reviewed Wdr91 B2RZ17 reviewed Fbxw2 B2RZ27 reviewed Sh3bgrl3 B2RZ46 unreviewed Rab17 B2RZ78 reviewed Vps29 B3DHR1 unreviewed fgf3 B3DI75 unreviewed fam20a B3RKL7 unreviewed B3RLE3 unreviewed B3RLE4 unreviewed B3RLE5 unreviewed B3RUL6 unreviewed B3RUN3 unreviewed B3RVA9 unreviewed B3RVF2 unreviewed B3RVG5 unreviewed B3RVK0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation B3S5X7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation B3S6S1 unreviewed B3SFS6 unreviewed B4ER10 reviewed IFNL3 B4F786 unreviewed Cd2bp2 B4F795 reviewed Slc44a2 B4F7E8 reviewed Niban2 B4FMX0 unreviewed B4HNS1 reviewed Tret1-2 B4QBN3 reviewed Tret1-2 B5DE08 unreviewed chpf2 B5DF13 unreviewed Trim59 B5DFA1 reviewed Tbc1d2 B5DFN2 reviewed Ahcyl1 In spite of its similarity with AHCY, which catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, recombinant AHCYL1 expressed in bacteria shows no hydrolase activity, nor does it affect the enzyme activity of AHCY B5LUQ7 reviewed B5LUQ8 reviewed B5LUQ9 reviewed B5LUR0 reviewed B5LUR1 reviewed B5RJR1 unreviewed dachs B5RSL8 unreviewed B6D5I5 unreviewed trpa1b B6EUB3 reviewed PDS5A B6H233 reviewed ecm14 Lacks the conserved Glu residue in position 467 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates B6JVC2 unreviewed whr1 B6JVM7 unreviewed chs2 B6JW46 unreviewed ned8 B6JW51 unreviewed cts2 Lacks conserved residue(s) required for the propagation of feature annotation B6JY05 unreviewed msc1 Lacks conserved residue(s) required for the propagation of feature annotation B6JZV3 unreviewed mid1 B6K877 unreviewed vma13 B6Q972 reviewed ecm14 Lacks the conserved Glu residue in position 493 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates B6TMJ4 unreviewed B7F4A9 unreviewed B7USF9 unreviewed gapA B7WN96 reviewed elt-3 Expressed in the intestine (PubMed:18662544). However, others have been unable to detect intestinal expression (PubMed:22001047). Based on lifespan assays conducted with a putative null allele, elt-3(vp1), represses longevity caused by a daf-2(e1370) mutant background (PubMed:18662544). However, this repression could not be reproduced (PubMed:22001047). Based on further analysis, the failure to reproduce seems to be due to a novel, unknown, mutation which arose in the daf-2(e1370) mutant background in one lab, but not the other (PubMed:23262285) B7YZS7 unreviewed kappaB-Ras Lacks conserved residue(s) required for the propagation of feature annotation B7YZT0 unreviewed mtt B7Z0C3 unreviewed PGRP-LD B7Z0L3 unreviewed CG5240 Lacks conserved residue(s) required for the propagation of feature annotation B7Z0L6 unreviewed wrd B7Z0L7 unreviewed wrd B7Z0M7 unreviewed Sordl B7Z0M8 unreviewed Sordl B7Z0Y2 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation B7Z0Z7 unreviewed BcDNA:GH06235 B7Z107 unreviewed Dmel\CG42376 B7Z139 unreviewed Kap3 B8AM21 reviewed B8B2D0 reviewed CDT1 B8BRE1 unreviewed B8E2P9 unreviewed B8JM95 unreviewed wnt11f2 B8LDQ4 unreviewed B8M2K0 reviewed ecm14 Lacks the conserved Glu residue in position 490 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates B8NBP9 reviewed ecm14 Lacks the conserved Glu residue in position 482 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates B8QB46 reviewed terf2ip B8ZV93 reviewed tam B8ZV94 reviewed tam B9A0M5 unreviewed Cby B9DGD6 reviewed ACS B9DH75 unreviewed B9DHQ0 reviewed TUBA5 B9EJR8 reviewed Dnaaf5 B9HFA8 unreviewed B9HGV6 unreviewed B9ID04 unreviewed B9MXK5 unreviewed B9MZ16 unreviewed C0H4U7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation C0HJC4 reviewed C0HJF8 reviewed C0HJH9 reviewed C0HJI0 reviewed C0HJX2 reviewed Lilrb3a C0HJX3 reviewed Lilrb3b C0HK25 reviewed C0HKH6 reviewed This peptide is linear as it lacks the C-terminal Asp/Asn residue required for cyclization C0HL13 reviewed LRP2 C0HLM0 reviewed C0HLM1 reviewed C0HLZ9 reviewed BaraA1 C0LU14 unreviewed cacna1sa C0NM08 reviewed ECM14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C0P4F3 unreviewed C0P6A0 unreviewed C0P6C4 unreviewed C0P6T7 unreviewed C0SAI5 reviewed ECM14 Lacks the conserved Glu residue in position 489 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C0SQ89 reviewed CMT3 C1C3I0 unreviewed eIF4EHP C1GDH9 reviewed ECM14 Lacks the conserved Glu residue in position 489 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C1HE31 reviewed ECM14 Lacks the conserved Glu residue in position 489 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C3Y8L8 unreviewed LOC118417016 C3YCW3 unreviewed LOC118426431 C3ZRF6 unreviewed LOC118411534 C4JEE1 reviewed ECM14 Lacks the conserved Glu residue in position 490 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C4LVJ5 unreviewed C4LXD3 unreviewed C5FPR9 reviewed ECM14 Lacks the conserved Glu residue in position 503 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C5G6D7 reviewed chonabc C5G6U8 reviewed ECM14 Lacks the conserved Glu residue in position 487 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C5JZS0 reviewed ECM14 Lacks the conserved Glu residue in position 487 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C5PHW9 reviewed ECM14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C5WPM7 unreviewed C5YN18 unreviewed C5YT12 unreviewed C5YT27 unreviewed C5YTC8 unreviewed C5YZK8 unreviewed C5YZK9 unreviewed C5Z1R2 unreviewed C5Z477 unreviewed C6H4F1 reviewed ECM14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates C6SVP6 unreviewed C6T483 unreviewed C6T4X8 unreviewed C6TLP0 unreviewed C6TP33 unreviewed bma C7LAF5 unreviewed EHR C8VPK6 unreviewed D0ZY51 reviewed degS D2A591 unreviewed AUGUSTUS-3.0.2_15494 D2CSU5 reviewed CM2 D2DHG1 unreviewed prox3 D3GDK4 reviewed D3GE74 reviewed STR D3J163 reviewed VPYL D3U715 reviewed ADT1 D3Z6P0 reviewed Pdia2 D3Z898 unreviewed Samhd1 D3Z902 reviewed Fbxw7 D3Z930 unreviewed Mettl17 D3Z9M1 unreviewed Mettl16 D3ZAH4 unreviewed Skor2 D3ZAP9 unreviewed Gpd1l D3ZAS8 unreviewed Sart3 D3ZAS9 unreviewed Ddrgk1 D3ZBP3 unreviewed Exosc2 D3ZC60 unreviewed Eme2 D3ZCL3 reviewed Snrpc D3ZCM3 reviewed Abcg4 D3ZCS5 unreviewed Eme1 D3ZCX1 unreviewed Mbd6 D3ZDX9 reviewed Mcidas D3ZE01 unreviewed Kif14 D3ZE02 unreviewed C1h19orf33 D3ZE05 unreviewed Cilp2 Lacks conserved residue(s) required for the propagation of feature annotation D3ZE77 unreviewed Mier3 D3ZEG0 unreviewed H1f8 D3ZEK7 unreviewed Steap1 D3ZF03 unreviewed Aifm3 Lacks conserved residue(s) required for the propagation of feature annotation D3ZF18 reviewed D3ZF70 unreviewed Sack1b D3ZFD0 reviewed Myo18a D3ZFN6 unreviewed Mettl8 D3ZFP4 unreviewed Mcm3 D3ZFY0 unreviewed Sephs1 D3ZG52 reviewed Dna2 D3ZG75 unreviewed Als2cl D3ZGE9 unreviewed Rbm38 D3ZGQ8 unreviewed Rsf1 D3ZGX8 unreviewed Brd4 D3ZH66 unreviewed Taf5 D3ZH90 unreviewed Nme5 Lacks conserved residue(s) required for the propagation of feature annotation D3ZHA1 unreviewed B4gat1 D3ZHD1 unreviewed Anxa13 D3ZHD6 unreviewed Rbm15b D3ZI68 unreviewed Prpf31 D3ZIA7 unreviewed Agr2 D3ZIE4 reviewed Fyb1 D3ZIM5 unreviewed Fcho1 D3ZIQ1 unreviewed Acot4 D3ZIS0 reviewed Slc5a4 D3ZJ86 reviewed Slc9a6 D3ZJB7 unreviewed Slc30a10 D3ZJE0 unreviewed Edem1 D3ZK09 unreviewed Scyl3 D3ZKA0 unreviewed Serpinb13 D3ZKD3 reviewed Alkbh5 D3ZKR9 unreviewed Tut7 D3ZKX9 reviewed Aloxe3 D3ZL57 unreviewed Usp6nl D3ZM64 unreviewed Jade1 D3ZM70 unreviewed Vstm2a Lacks conserved residue(s) required for the propagation of feature annotation D3ZMI0 unreviewed Angptl8 D3ZMI6 unreviewed Olfm4 Lacks conserved residue(s) required for the propagation of feature annotation D3ZMK9 reviewed Prag1 Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity (PubMed:29503074) D3ZML2 reviewed Brsk2 D3ZNF5 reviewed Tmem63c D3ZNQ0 unreviewed Crip3 D3ZNU1 unreviewed Cebpz D3ZP89 unreviewed Kdm1b D3ZP96 unreviewed Mcm2 Lacks conserved residue(s) required for the propagation of feature annotation D3ZP98 unreviewed Hm13 D3ZPP3 unreviewed Psd4 D3ZQ06 unreviewed Dnd1 D3ZQ25 unreviewed Fbln1 Lacks conserved residue(s) required for the propagation of feature annotation D3ZQF4 reviewed Fkbp6 Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity D3ZQI4 unreviewed Zfand1 D3ZQL6 reviewed Micall1 D3ZQP6 unreviewed Sema7a Lacks conserved residue(s) required for the propagation of feature annotation D3ZR43 unreviewed Angpt4 D3ZRK7 unreviewed Cdc6 D3ZRW8 reviewed Etnk2 D3ZS29 unreviewed Nanog D3ZS84 unreviewed Socs6 D3ZSK6 unreviewed Dact2 D3ZSR2 unreviewed Pabpc4 D3ZSY8 unreviewed Tbc1d10b D3ZT51 unreviewed Exosc3 D3ZT95 unreviewed Ercc4 D3ZTJ0 unreviewed Rp2 Lacks conserved residue(s) required for the propagation of feature annotation D3ZTJ6 unreviewed Tpcn2 D3ZU63 unreviewed Stard13 D3ZUD5 unreviewed Ofd1 D3ZUL8 unreviewed Zcchc8 D3ZUT0 unreviewed Kif26a D3ZUY0 unreviewed Rdh14 D3ZV74 unreviewed Nudt7 Lacks conserved residue(s) required for the propagation of feature annotation D3ZVH0 unreviewed Stradb D3ZVK1 reviewed Mcm8 D3ZVR7 reviewed Prxl2b D3ZVR9 reviewed Pgm5 D3ZW38 unreviewed Exosc6 D3ZW78 unreviewed Cpxm1 Lacks conserved residue(s) required for the propagation of feature annotation D3ZWJ0 unreviewed Gmnn D3ZWK4 reviewed L3mbtl1 D3ZWL6 unreviewed Ahcyl2 D3ZX42 unreviewed Rabgap1 D3ZY54 unreviewed Slc30a5 D3ZYB8 unreviewed Tex15 D3ZYQ9 unreviewed Rnf20 D3ZYR1 reviewed Fcho2 D3ZYT8 unreviewed Pikfyve D3ZYW8 unreviewed Tmem266 D3ZYY9 unreviewed Usp53 D3ZZ97 unreviewed Ror1 Lacks conserved residue(s) required for the propagation of feature annotation D3ZZK3 unreviewed Epha4 D3ZZL9 reviewed Gcc2 D3ZZP1 unreviewed Slc37a3 D3ZZS8 unreviewed Atp6v1b1 D4A055 reviewed Cacnb4 D4A0U9 unreviewed Msh6 D4A0Y6 unreviewed Mki67 D4A193 unreviewed Reep1 D4A1I9 unreviewed Ppil6 D4A1J4 reviewed Bdh2 Postulated to act as a 3-hydroxybutyrate dehydrogenase, however its contribution to ketone body formation appears to be physiologically irrelevant since it has very low affinity for the substrate D4A1Q9 unreviewed Ttll12 D4A2H2 reviewed Sptlc1 D4A2H6 unreviewed Rbfox3 D4A2W7 unreviewed Setd5 Lacks conserved residue(s) required for the propagation of feature annotation D4A304 unreviewed Diras1 D4A332 unreviewed Ankle1 D4A3I1 unreviewed Tnfsf18 Lacks conserved residue(s) required for the propagation of feature annotation D4A3L4 unreviewed Trim6 D4A494 unreviewed Dmrtb1 D4A4P8 unreviewed Ttyh2 Lacks conserved residue(s) required for the propagation of feature annotation D4A4S5 unreviewed Folr2 D4A4T9 reviewed Chordc1 D4A4X6 unreviewed Adamtsl2 Lacks conserved residue(s) required for the propagation of feature annotation D4A4Y0 unreviewed Exosc4 D4A527 unreviewed Prss37 Lacks conserved residue(s) required for the propagation of feature annotation D4A563 unreviewed Peak1 D4A5A6 unreviewed Polr2a D4A631 reviewed Arfgef1 D4A693 reviewed Azin2 Human ortholog was initially reported to have ornithine decarboxylase or arginine decarboxylase activities, but it was later found that the mouse ortholog does not possess neither of them D4A6D8 reviewed Lrrtm1 D4A6T2 unreviewed Rpusd3 D4A6T9 unreviewed Mark4 D4A6Z8 reviewed Kcnu1 D4A7J3 unreviewed Abca12 D4A8X5 unreviewed Gpr45 Lacks conserved residue(s) required for the propagation of feature annotation D4A8Y0 unreviewed Cldn12 D4A929 reviewed Wdr81 D4A986 unreviewed Mbd2 D4A9L9 unreviewed Erp27 D4A9M7 unreviewed Atg16l2 D4A9N5 unreviewed Trim25 D4AAB5 unreviewed Pm20d2 D4AAE7 unreviewed Slc31a2 D4AAT7 reviewed Naxd D4AAW7 unreviewed Best3 D4ABB2 unreviewed Mlc1 D4ABL6 reviewed Mctp1 D4ABN7 unreviewed Padi6 D4ABV1 unreviewed Gtpbp2 Lacks conserved residue(s) required for the propagation of feature annotation D4ABW7 reviewed Lyzl4 Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity D4ABY0 unreviewed Cplx3 D4AC13 reviewed Lgr5 D4ACA2 unreviewed Hemk2 D4ADK7 unreviewed Meltf Lacks conserved residue(s) required for the propagation of feature annotation D4ADR5 unreviewed Chpf2 D4ADS4 unreviewed Mgst3 D4AE25 unreviewed Cd274 Lacks conserved residue(s) required for the propagation of feature annotation D4AE48 reviewed Midn D4AE98 unreviewed Exosc8 D4AEG7 unreviewed Tbc1d13 D4AEI0 unreviewed Tas2r145 D4AKU7 reviewed ECM14 Lacks the conserved Glu residue in position 512 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates D4DIW7 reviewed ECM14 Lacks the conserved Glu residue in position 512 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates D4HR93 unreviewed PR10.1 D5VRB9 reviewed D6RGH6 reviewed MCIDAS D6W7F8 unreviewed AUGUSTUS-3.0.2_05166 D6W7I8 unreviewed AUGUSTUS-3.0.2_10814 Lacks conserved residue(s) required for the propagation of feature annotation D6WCP6 unreviewed AUGUSTUS-3.0.2_00165 D6WGE0 unreviewed AUGUSTUS-3.0.2_10332 D6WGY6 unreviewed AUGUSTUS-3.0.2_30730 Lacks conserved residue(s) required for the propagation of feature annotation D6WIN6 unreviewed AUGUSTUS-3.0.2_02791 Lacks conserved residue(s) required for the propagation of feature annotation D6WL56 unreviewed AUGUSTUS-3.0.2_14299 D6WMP7 unreviewed AUGUSTUS-3.0.2_13906 D6WQD5 unreviewed AUGUSTUS-3.0.2_08925 D6WQR4 unreviewed AUGUSTUS-3.0.2_08867 D6WSH0 unreviewed AUGUSTUS-3.0.2_09563 D6WUX3 unreviewed AUGUSTUS-3.0.2_05995 Lacks conserved residue(s) required for the propagation of feature annotation D6WVM8 unreviewed AUGUSTUS-3.0.2_05905 Lacks conserved residue(s) required for the propagation of feature annotation D6WVM9 unreviewed AUGUSTUS-3.0.2_05904 Lacks conserved residue(s) required for the propagation of feature annotation D7EIK6 unreviewed AUGUSTUS-3.0.2_01438 D7FB54 unreviewed rltgr D7SP59 unreviewed D7T1T3 unreviewed D7TGZ0 unreviewed D7U316 unreviewed D7U4Q7 unreviewed D7UNT2 reviewed Rs-cdh D7URM0 reviewed Xt-cdh D7URV0 reviewed nphT7 D8QPB1 unreviewed D8RGT0 unreviewed D8RHS5 unreviewed D8RWM5 unreviewed D8S4Y6 unreviewed D8S648 unreviewed D8SL64 unreviewed D8T2I7 unreviewed D8T3E1 unreviewed D8T631 unreviewed D8T7X1 unreviewed E1B913 unreviewed THNSL2 E1B9D0 unreviewed CHPF2 E1BB03 reviewed ZRANB3 E1BB43 unreviewed RPS6KC1 E1BDI1 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation E1BDW7 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation E1BER6 unreviewed CRMP1 E1BGC6 unreviewed MLKL E1BIY2 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation E1BJ18 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation E1BJ64 unreviewed E1BLR4 unreviewed RHBDF2 E1BMM8 unreviewed CHPF E1BMP7 reviewed DNA2 E1BNR9 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation E1BP77 unreviewed AFF2 E1BRE2 reviewed SIRT5 E1BYJ2 reviewed MSH6 E1C6F2 unreviewed MLKL E1JGZ9 unreviewed Prosalpha1R E1JHQ6 unreviewed Eaat2 E1JHZ1 unreviewed Atg1 E1JI40 unreviewed verm E1JI87 unreviewed PGRP-LC E1JI88 unreviewed PGRP-LC E1JI89 unreviewed PGRP-LC E1JIV5 unreviewed eIF4EHP E1JJ58 unreviewed Dmel\CG2082 E2QC84 unreviewed kermit E2QCW2 unreviewed Pi3K68D Lacks conserved residue(s) required for the propagation of feature annotation E2QD98 unreviewed sdt E2RG75 unreviewed RNASE9 E2RTQ7 reviewed E2RU10 reviewed EB1 E3CTS5 unreviewed Ilk E3JY16 unreviewed E3KIR4 unreviewed E3KJE6 unreviewed E3W6T6 unreviewed tbx5b Lacks conserved residue(s) required for the propagation of feature annotation E4UPZ6 reviewed ECM14 Lacks the conserved Glu residue in position 512 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates E5A0U8 reviewed ECM14 Lacks the conserved Glu residue in position 504 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates E5DHB5 reviewed lgr5-a E7EI18 unreviewed E7EKH1 reviewed E7EKH3 reviewed E7EKH4 reviewed E7EKH5 reviewed E7EKH6 reviewed E7EKH7 reviewed E7EKI0 reviewed E7EKI9 reviewed E7EKJ5 reviewed E7EKJ6 reviewed E7EKJ7 reviewed E7EKM1 reviewed E7F1H9 reviewed ythdf2 E7F6J7 unreviewed jarid2a Lacks conserved residue(s) required for the propagation of feature annotation E7F829 unreviewed aebp1a Lacks conserved residue(s) required for the propagation of feature annotation E7F9K2 unreviewed chpfb E7FAI5 unreviewed ryk Lacks conserved residue(s) required for the propagation of feature annotation E7FBE1 unreviewed sema7a Lacks conserved residue(s) required for the propagation of feature annotation E7FCE3 unreviewed grhl1 E7FE13 reviewed lgr4 E8NHB1 unreviewed Taf2 E9ACA4 unreviewed E9ACP3 unreviewed E9ADS3 unreviewed E9ADX4 unreviewed TXN1 E9AES9 unreviewed E9AET2 unreviewed E9AFP5 unreviewed E9DD69 reviewed ECM14 Lacks the conserved Glu residue in position 488 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates E9FY81 unreviewed E9G1D6 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation E9G357 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation E9G3K5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation E9G3U3 unreviewed E9G5V9 unreviewed E9G6P2 unreviewed E9GFW8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation E9GI34 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation E9GM26 unreviewed E9GP55 unreviewed E9GQY8 unreviewed E9GWW1 unreviewed E9HA67 unreviewed E9HI84 unreviewed E9HIU6 unreviewed E9HK94 unreviewed E9HSV9 unreviewed PMY E9PT20 unreviewed Abl1 E9PT72 unreviewed Tbc1d21 E9PT83 unreviewed Cenpf E9PT87 reviewed Mylk3 E9PTA2 reviewed Trpm2 E9PTP3 unreviewed Gjd3 E9PTS6 unreviewed Klf11 E9PU02 unreviewed Trappc9 E9PVX6 reviewed Mki67 Was thought to play a key role in cell proliferation, and is commonly used as a marker of cell proliferation. However, its primary function is uncoupled from cell proliferation (PubMed:26949251). Required to maintain mitotic chromosomes dispersed by forming a steric and electrostatic charge barrier (PubMed:27362226) E9PXV9 reviewed Obox2 E9PYK3 reviewed Parp4 E9Q3P4 unreviewed Cenpf E9Q5R7 reviewed Nlrp12 E9Q876 reviewed Abca12 F0ZCK3 unreviewed F0ZGQ1 unreviewed F0ZKX2 unreviewed F0ZPQ8 unreviewed F0ZWZ5 unreviewed F1LJ00 unreviewed TBC1D18 F1LM81 reviewed Tom1l1 F1LMV6 reviewed Dsp F1LN46 reviewed Cpt1c In contrast to its paralogs, CPT1A and CPT1B, does not have, or at very low levels, carnitine O-palmitoyltransferase activity (EC:2.3.1.21) in vivo, being unable to catalyze the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine. This is in agreement with its expression specific to neurons which is a cell-type that does not use fatty acids as fuel to any major extent and the fact that it locates to endoplasmic reticulum instead of mitochondria F1LN63 unreviewed Tlr3 Lacks conserved residue(s) required for the propagation of feature annotation F1LP13 unreviewed Ptprg Lacks conserved residue(s) required for the propagation of feature annotation F1LPJ7 unreviewed Usp33 F1LPS6 unreviewed Ifit1 F1LQ70 reviewed Alox12 F1LQQ7 reviewed Scn7a F1LR42 unreviewed Rufy1 F1LRL4 unreviewed Tbc1d9b F1LSG8 reviewed Vps50 F1LTH9 unreviewed Wrn F1LUQ0 unreviewed Mcub F1LUQ5 unreviewed Ago4 F1LUS2 unreviewed Ago3 F1LVE6 unreviewed Ldc1 F1LVL5 unreviewed Shroom4 F1LVS9 unreviewed Zfp496 F1LW77 unreviewed Rab33b Lacks conserved residue(s) required for the propagation of feature annotation F1LWX6 unreviewed Haus3 F1LWZ3 unreviewed Rhbdf2 F1LWZ7 unreviewed Tbc1d8 F1LXH1 unreviewed Accs F1LZH3 unreviewed Ezh1 F1M0A0 unreviewed Ano3 F1M1L9 unreviewed Cpne2 F1M1Y3 unreviewed Frmd7 F1M2P2 unreviewed Cripto Lacks conserved residue(s) required for the propagation of feature annotation F1M386 reviewed Rapgef2 F1M5F3 reviewed Mcm9 F1M6A9 unreviewed Cerkl F1M6E7 unreviewed Spaca3 Lacks conserved residue(s) required for the propagation of feature annotation F1M6S6 unreviewed Mbd1 F1M784 unreviewed Pik3ap1 Lacks conserved residue(s) required for the propagation of feature annotation F1M816 unreviewed Spen F1M928 reviewed Izumo1r F1M9D6 unreviewed Stat1 F1MA98 reviewed Tpr F1MAD0 unreviewed Lrp5 Lacks conserved residue(s) required for the propagation of feature annotation F1MJW4 unreviewed FAM20A F1MKG3 unreviewed DMRTC2 F1MLB9 unreviewed NT5C3B F1MLD0 unreviewed PANK4 F1MLX5 reviewed LGR4 F1MT22 reviewed LGR5 F1MX60 unreviewed CYFIP2 F1MX99 unreviewed FRMD7 F1MXF0 unreviewed F1MZ64 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation F1MZD6 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation F1MZE0 unreviewed LGSN F1N1C7 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F1N2W9 reviewed MCM9 F1N404 unreviewed PADI6 F1NE09 unreviewed CYFIP2 F1NQJ3 reviewed PMS2 F1P0W8 unreviewed GPD1L F1P3H0 unreviewed BMPR1A F1Q4X7 unreviewed whr1 F1Q679 unreviewed chpf2 F1QCV2 reviewed hdac10 Originally thought to be a histone deacetylase and shown in vitro to have this activity (By similarity). Has also been shown to be involved in MSH2 deacetylation (By similarity). However, protein deacetylase activity is a matter of debate, as 3D structure analysis shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates (By similarity) F1QG30 reviewed smpd5 F1QGH7 reviewed ctnnb1 F1QKB5 unreviewed ror1 Lacks conserved residue(s) required for the propagation of feature annotation F1QLG2 unreviewed mta2 F1QMF9 unreviewed nedd8 F1QT23 unreviewed rdh8b F1QUP2 unreviewed hsd17b1 F1R336 unreviewed tcf7l1b F1R777 reviewed mettl3 F1R7L6 unreviewed chpfa F1RAC0 unreviewed aebp1b Lacks conserved residue(s) required for the propagation of feature annotation F1RE66 unreviewed robo4 Lacks conserved residue(s) required for the propagation of feature annotation F1REK1 unreviewed hgfa Lacks conserved residue(s) required for the propagation of feature annotation F1RET2 reviewed smyd5 F1RGZ3 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation F1RQE9 unreviewed CYFIP2 F1RQS9 unreviewed SNX15 F1RR83 unreviewed CERCAM F1RV24 unreviewed FAM20A F1RWU4 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation F1RX94 unreviewed GRB7 F1RXR5 unreviewed MLC1 F1RZ68 unreviewed RHBDF2 Lacks conserved residue(s) required for the propagation of feature annotation F1S0E1 unreviewed PM20D2 F1S2R9 unreviewed RPS6KL1 F1S2X9 unreviewed RPS6KC1 F1S8I0 unreviewed RNASE12 F1SAG5 unreviewed MCOLN2 F1SB93 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation F1SDQ2 unreviewed DPYSL5 F1SEL4 unreviewed PTPN20 F1SH50 unreviewed TRIM59 F1SJE6 unreviewed PGM5 F1SPK2 unreviewed H1-8 F1SPS6 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation F1SQW6 unreviewed ERP27 F1SSF7 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F1SSM9 unreviewed CHPF2 F1SUQ9 unreviewed PADI6 F1SV82 unreviewed AZIN2 F1SVA3 unreviewed LOC100520618 F1T153 reviewed F1T154 reviewed F1T155 reviewed F2CSG6 unreviewed F2D139 unreviewed F2DS45 unreviewed F2E6E2 unreviewed F2E8Z3 unreviewed F4HTP2 unreviewed POLA2 F4HUN9 unreviewed ATEH1 F4HWC3 unreviewed F4HYF3 reviewed DCD F4HZD1 reviewed JMJ24 F4I1S7 reviewed ELP2 The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification F4I240 reviewed JMJ17 F4I2A0 unreviewed F4I420 unreviewed EIF5B1 F4I4W2 reviewed HCS2 F4I6B2 unreviewed F4I6G4 reviewed JMJ18 F4I730 unreviewed F4I7I0 reviewed ALAAT1 F4I893 reviewed ILA F4IC89 unreviewed F4IH25 reviewed BOP1 F4IHV8 unreviewed LHB1B1 F4IHY7 reviewed PTAC12 F4IIM1 reviewed CSI1 F4IJZ6 reviewed SSL1 F4IL30 reviewed POP1 F4IL68 unreviewed TASH3 F4IMB5 unreviewed F4IMQ9 unreviewed EMB3147 F4IP13 reviewed SGR6 F4IPE3 reviewed SGR5 F4IPJ1 unreviewed TRA1A F4IRX7 unreviewed SOUL-1 F4ISU2 unreviewed PICC F4ITX4 unreviewed EMB2765 F4IVL6 reviewed GRV2 F4IW47 reviewed TKL-2 F4IXH9 unreviewed F4IYB2 unreviewed F4IYB5 unreviewed F4J6B0 unreviewed PPT F4J8K6 reviewed RRP5 F4J9A0 unreviewed NODGS F4JCA8 unreviewed F4JCI4 unreviewed APSE F4JCS8 unreviewed SUO F4JCX0 unreviewed F4JF14 reviewed EOL1 F4JHH5 reviewed SEC15B F4JJL0 reviewed ENDO4 F4JL52 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation F4JL64 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation F4JLP5 reviewed LPD2 F4JMJ1 reviewed HSP70-17 F4JP43 reviewed SWO1 F4JPM9 unreviewed F4JQ94 unreviewed PCP-LIKE F4JQZ3 reviewed REN1 F4JRB5 unreviewed NASP F4JRD9 unreviewed ATSPEN2 F4JRR1 reviewed COG2 F4JSG5 unreviewed F4JT76 reviewed VPS54 F4JVN6 reviewed TPP2 F4JXK0 unreviewed MPA24.11 F4JY24 reviewed CHR17 F4JY37 reviewed RUK F4JY76 unreviewed F4JZY1 reviewed CIP1 F4K1D3 unreviewed MXH1.2 F4K1Z0 reviewed ECT3 F4K2F1 unreviewed SELO F4K455 unreviewed F4K4Y5 reviewed DEK4 F4K529 unreviewed F4K5Y5 unreviewed MNL12.14 F4KBF3 reviewed AAE17 F4KCC2 reviewed PRT6 F4KH02 unreviewed LUC7B F4KIH8 unreviewed TWD40-2 F4NY74 unreviewed F4PDC8 unreviewed F4PER0 unreviewed F4YAW0 unreviewed BCP1 Lacks conserved residue(s) required for the propagation of feature annotation F4YAW1 unreviewed BCP2 Lacks conserved residue(s) required for the propagation of feature annotation F4YAW2 unreviewed BCP3 F4YAW3 unreviewed BCP4 Lacks conserved residue(s) required for the propagation of feature annotation F6GZ17 unreviewed F6H2H2 unreviewed F6HUV2 unreviewed F6PFR0 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F6PFV4 unreviewed CYFIP2 F6PHZ6 reviewed FKBP6 Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity F6PLZ7 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F6Q528 unreviewed Siglech Lacks conserved residue(s) required for the propagation of feature annotation F6Q9N8 unreviewed F6QDT9 unreviewed LOC100177957 Lacks conserved residue(s) required for the propagation of feature annotation F6QQS4 unreviewed F6QXW0 reviewed dna2 F6QXX8 unreviewed LOC100176246 F6QYR2 unreviewed F6R8D1 unreviewed MCOLN2 F6RGZ9 unreviewed CYFIP2 F6RQC6 unreviewed STK19 F6RT19 unreviewed STK19 F6RUP2 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation F6RVP2 unreviewed DPYSL4 F6S280 unreviewed MCOLN2 F6S337 unreviewed MLKL F6SA83 unreviewed F6SB02 unreviewed HYAL3 F6SCG6 unreviewed CHPF2 F6SIF5 unreviewed F6SKY7 unreviewed CERCAM F6SNC6 unreviewed F6T0X8 unreviewed RNASE10 F6T1M0 unreviewed NEDD8 F6T3F3 unreviewed thnsl2 F6T6P8 unreviewed NUDT16L1 F6TAH9 unreviewed AHCYL2 F6TCT5 unreviewed LOC703578 F6TEW7 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation F6TMR0 unreviewed RNASE12 F6TN77 unreviewed PM20D2 F6TS31 unreviewed FRMD7 F6TU58 unreviewed F6U9E5 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation F6UNH1 unreviewed Peg12 F6UTS9 unreviewed F6V3F6 unreviewed PM20D2 F6V3S6 unreviewed RNASE13 F6VBW3 unreviewed F6VCI5 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation F6VDV5 unreviewed CYFIP2 F6VNW2 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation F6VZY0 unreviewed AZIN2 F6W4Y0 unreviewed LGSN F6WC66 unreviewed DPYSL3 F6WFV9 unreviewed FAM20A F6WP48 unreviewed RPS6KC1 F6WQY8 unreviewed LOC100086893 F6WUY4 unreviewed PGM5 F6WY12 unreviewed aff2 F6X3G4 unreviewed PADI6 F6X8N6 unreviewed Kcnk15 F6X9L5 unreviewed LOC100179675 F6XE11 unreviewed rps6kc1 F6XU73 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation F6XU97 unreviewed DPYSL5 F6Y0F0 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation F6Y3Q6 unreviewed SUCLG2 F6Y4X6 unreviewed RHBDF2 F6YEC9 unreviewed LGSN F6YK29 unreviewed LOC100184967 F6YNC9 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation F6YQP3 unreviewed AFF2 F6YQY7 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation F6YTR6 unreviewed RHBDF2 Lacks conserved residue(s) required for the propagation of feature annotation F6YWL8 unreviewed DMRTC2 F6YXB1 unreviewed F6YZC1 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation F6ZD53 unreviewed NT5C3B F6ZDS4 reviewed Tpr F6ZFI0 unreviewed F6ZNK3 unreviewed LOC100077254 F6ZPC8 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation F6ZT04 unreviewed RPS6KL1 F6ZT50 unreviewed DPYSL5 F6ZTP3 unreviewed LGSN F7A0V8 unreviewed FRMD7 F7A280 unreviewed F7A3I8 unreviewed RHBDF2 F7A5G3 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation F7A9D7 unreviewed PANK4 F7AN36 unreviewed F7APW3 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation F7AU74 unreviewed RPS6KL1 F7B2M8 unreviewed F7B3R6 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation F7B3V8 unreviewed THNSL2 F7BHI4 unreviewed MCOLN2 F7BMS3 unreviewed CRMP1 F7BT74 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation F7BU24 unreviewed dpysl5 F7BXI2 unreviewed WHR1 F7BYX4 unreviewed NRBP1 F7C2Y5 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F7C7V8 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation F7C843 unreviewed FAM20A F7CI47 unreviewed SNX15 F7CM35 unreviewed GRB7 F7CP61 unreviewed CERCAM F7CRL8 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation F7CVF2 unreviewed DPYSL5 F7CXX5 unreviewed LOC100425237 F7CYX6 unreviewed CHPF F7D3V9 reviewed lgr5 F7D735 unreviewed Pabpc4 F7D9T6 unreviewed nt5c3b F7DG00 unreviewed SNX15 F7DHM2 unreviewed TRIM59 F7DIK9 unreviewed DPYSL3 F7DJ58 unreviewed PANK4 F7DKV7 reviewed sirt5 F7DMI7 unreviewed DPYSL2 F7DQ20 unreviewed RHBDF2 F7DXA3 unreviewed CRMP1 F7DXF1 unreviewed DPYSL4 F7E383 unreviewed LOC103098338 F7E994 unreviewed PTPN20 F7E9G3 unreviewed MLC1 F7EDW8 unreviewed mst1 Lacks conserved residue(s) required for the propagation of feature annotation F7EG06 unreviewed SUCLG2 F7EKA4 unreviewed Ugt1a8 F7EKN7 unreviewed CRMP1 F7ELV6 unreviewed TRIM59 F7EPE8 unreviewed mlkl F7EPI0 unreviewed Sar1a F7EPZ4 unreviewed Dis3 F7EUQ5 unreviewed Mtap Lacks conserved residue(s) required for the propagation of feature annotation F7EWP1 unreviewed Ube2a F7EY92 unreviewed Mbd3 F7EZK6 unreviewed Galk1 F7F0D5 unreviewed Upp1 F7F115 unreviewed Upf3a F7F135 unreviewed RPS6KL1 F7F2Q6 unreviewed Ythdf1 F7F2V3 unreviewed F7F3A4 unreviewed KCNU1 F7F4T7 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation F7F5Y8 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation F7F640 unreviewed Rnase2 F7F7A6 unreviewed Eif4a1 F7F8E2 unreviewed F7FCL0 unreviewed F7FEJ7 unreviewed NRBP1 F7FFC6 unreviewed Mettl3 F7FGC1 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation F7FHW6 unreviewed Shq1 F7FJV3 unreviewed Creb3 F7FKB0 unreviewed MCOLN2 F7FL45 unreviewed F7FMS0 unreviewed Mst1 Lacks conserved residue(s) required for the propagation of feature annotation F7FPM8 unreviewed Snx6 F7FQG6 unreviewed URAD F7FSI1 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation F7FWT8 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation F7FZN3 unreviewed AZIN2 F7G4B9 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation F7G5G1 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation F7G5Q8 unreviewed LOC103098660 F7G717 unreviewed PDIA2 F7G8P6 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation F7G9S3 unreviewed FAM20A F7GC03 unreviewed PASD1 F7GHW3 unreviewed HYAL1 F7GKX7 unreviewed RNASE3 F7GVW0 unreviewed CERCAM F7H126 unreviewed AZIN2 F7H1W4 unreviewed CHPF2 F7HDM2 unreviewed TFDP3 F7HEB2 unreviewed GRB7 F7HH00 unreviewed CHI3L2 Lacks conserved residue(s) required for the propagation of feature annotation F7HHD9 unreviewed KCNU1 F7HMN7 unreviewed MLKL F7HU87 unreviewed PGM5 F8VPN2 reviewed Tex15 F8W2D1 unreviewed fkbp4 F8W479 unreviewed boka F8W4B7 unreviewed hdac6 F9VMT6 reviewed fbp G0S0R6 unreviewed G0X3E3 unreviewed MADS11 G1K9N7 unreviewed PGM5 G1KBX6 unreviewed GRB7 G1KF39 unreviewed RPS6KC1 G1KG92 unreviewed TRIM59 G1KH68 unreviewed dpysl4 G1KHM7 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation G1KHP5 unreviewed RHBDF2 G1KHS9 unreviewed THNSL2 G1KJ97 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation G1KJD2 unreviewed G1KKJ4 unreviewed ERP27 G1KLV8 unreviewed WHR1 G1KM02 unreviewed AHCYL1 G1KPM1 unreviewed CHPF G1KQ41 unreviewed GPD1L G1KQ65 unreviewed PM20D2 G1KT30 unreviewed RPS6KL1 G1KTJ9 unreviewed NT5C3B G1L681 unreviewed MLC1 G1LCQ0 unreviewed H1-8 G1NR41 unreviewed DRD1 Lacks conserved residue(s) required for the propagation of feature annotation G1NXY0 unreviewed HYAL1 G1QHQ9 unreviewed MLC1 G1R5P3 unreviewed HYAL1 G1SPB4 unreviewed HYAL1 G1U3F1 unreviewed MLC1 G2HFK4 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation G2HGN5 unreviewed G2HGP5 unreviewed G3MX27 unreviewed RPS6KL1 G3MZ45 unreviewed RNASE11 G3N2S2 unreviewed MCOLN2 G3QD81 unreviewed DPYSL2 G3QEM7 unreviewed LOC101136093 G3QIM9 unreviewed STK19 G3QJT9 unreviewed CHPF G3QKR8 unreviewed FAM20A G3QLL7 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation G3QMX0 unreviewed LGSN G3QNC0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation G3QP52 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation G3QQP6 unreviewed CERCAM G3QRV7 unreviewed URAD G3QST1 unreviewed PASD1 G3QUI5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation G3QVZ5 unreviewed HYAL1 G3QW80 unreviewed GPD1L G3QXW3 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation G3R1S3 unreviewed ERP27 G3R2R4 unreviewed PDIA2 G3R364 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation G3R3M8 unreviewed G3R3Q4 unreviewed NT5C3B G3R4G6 unreviewed SNX15 G3R4T3 unreviewed AFF2 G3R4W6 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation G3R6A8 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation G3R7C6 unreviewed KCNU1 G3R7I3 unreviewed RPS6KL1 G3R806 unreviewed AHCYL1 G3R915 unreviewed MCOLN2 G3RA55 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation G3RBK2 unreviewed DPYSL4 G3RBN3 unreviewed G3RD17 unreviewed G3RD64 unreviewed ROR1 Lacks conserved residue(s) required for the propagation of feature annotation G3RFZ8 unreviewed AZIN2 G3RGX7 unreviewed PADI6 G3RHH8 unreviewed RHBDF2 G3RJ38 unreviewed NEDD8 G3RJK5 unreviewed PM20D2 G3RM65 unreviewed CYFIP2 G3RY50 unreviewed LOC129530010 G3RYF7 unreviewed TFDP3 G3RZ39 unreviewed SUCLG2 G3S7K9 unreviewed NUDT16L1 G3SGQ5 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation G3T6H5 unreviewed HYAL1 G3THE9 unreviewed MLC1 G3V624 unreviewed Coro1c G3V645 reviewed Oasl G3V665 unreviewed Castor2 G3V6G1 unreviewed Jchain G3V6N7 unreviewed Slc12a6 G3V6U9 reviewed Setd3 G3V9C9 unreviewed Zmiz2 G3V9E2 unreviewed Alkbh6 G3V9M1 unreviewed Ddx23 G3V9N0 unreviewed Pabpc4 G3X6X9 unreviewed PM20D2 G3X7D2 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation G4VGH9 reviewed UPPB Although this protein has high similarity to uridine phosphorylases, it has no detectable catalytic activity. It contains substitutions at Gly-126 and Gln-201, two conserved sites which are known to be important for uridine binding G5E8H9 unreviewed Rdh19 G5EAW8 unreviewed digA G5EB08 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation G5ECH7 reviewed cdk-5 G5EDN1 unreviewed ace-4 G5EE06 reviewed fut-5 G5EEB2 unreviewed srbc-64 G5EEL7 unreviewed fut-4 G5EFH8 reviewed cbs-1 G5EFP5 reviewed fut-3 G5EGA9 reviewed sdf-9 Predicted to be inactive as the cysteine residue involved in the catalytic reaction is a lysine at position 223 G5EGT9 reviewed lin-18 May lack kinase activity. The human ortholog has been shown to have impaired catalytic activity with an inability to undergo autophosphorylation or to phosphorylate substrates G5EGU2 reviewed eak-6 Its phosphatase activity is uncertain. Lacks in vitro phosphatase activity with p-nitrophenylphosphate, even if the catalytic Cys is conserved G7IK38 unreviewed G7INQ6 unreviewed G7IQD5 unreviewed G7IQD8 unreviewed G7JYX3 unreviewed G7KGB6 unreviewed G7LD21 unreviewed G7MJE1 unreviewed TRIM59 G7NT58 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation G7NXS8 unreviewed G8BCM7 unreviewed PHO15 G8JZS4 reviewed susB Although initially defined as an alpha-glucosidase, it produces beta-glucose by an inverting mechanism, suggesting it rather acts as a glucan 1,4-alpha-glucosidase H2KYP7 unreviewed pnk-1 H2KZE5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation H2L2Y9 unreviewed lgsn H2L3V5 unreviewed AHCYL1 H2L616 unreviewed ryk Lacks conserved residue(s) required for the propagation of feature annotation H2L7C8 unreviewed aebp1a Lacks conserved residue(s) required for the propagation of feature annotation H2LF02 unreviewed mst1 Lacks conserved residue(s) required for the propagation of feature annotation H2LFU0 unreviewed fam20a H2LI40 unreviewed pgm5 H2LJR0 unreviewed pank4 H2LL75 unreviewed snx15 H2LN93 unreviewed mcoln2 H2LNS1 unreviewed ahcyl1 H2LSL3 unreviewed sema7a Lacks conserved residue(s) required for the propagation of feature annotation H2LUQ2 unreviewed cyfip2 H2LXX8 unreviewed stk19 H2LZ72 unreviewed aff2 H2M0V9 unreviewed hgfb Lacks conserved residue(s) required for the propagation of feature annotation H2M2Y8 unreviewed ror1 Lacks conserved residue(s) required for the propagation of feature annotation H2M521 unreviewed LOC101173464 H2M594 unreviewed AHCYL2 H2M764 unreviewed LOC101170578 H2M8E9 unreviewed chpf2 H2M9M6 unreviewed DPYSL2 H2MBR1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation H2MGE6 unreviewed grb7 H2MIK1 unreviewed LOC101173825 H2MJD9 unreviewed rps6kc1 H2MPZ7 unreviewed rps6kl1 H2MQC9 unreviewed PM20D2 H2MR63 unreviewed adamtsl2 Lacks conserved residue(s) required for the propagation of feature annotation H2MTK4 unreviewed dpysl5 H2MXR0 unreviewed dpysl3 H2N2I0 unreviewed dpysl4 H2P9C9 unreviewed LOC100450433 H2PXV0 unreviewed PANK4 H2Q0Y0 unreviewed CHI3L1 Lacks conserved residue(s) required for the propagation of feature annotation H2Q147 unreviewed RPS6KC1 H2Q2S9 unreviewed DPYSL4 H2Q415 unreviewed SNX15 H2Q5I8 unreviewed ERP27 H2Q7C6 unreviewed URAD H2Q9S6 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation H2QA67 unreviewed RHBDF1 Lacks conserved residue(s) required for the propagation of feature annotation H2QAI1 unreviewed NUDT16L1 H2QBI3 unreviewed MLKL H2QD06 unreviewed NT5C3B H2QDY1 unreviewed RHBDF2 H2QHN1 unreviewed NRBP1 H2QIB1 unreviewed THNSL2 H2QJH3 unreviewed CHPF H2QNC6 unreviewed H1-8 H2QNE9 unreviewed RYK Lacks conserved residue(s) required for the propagation of feature annotation H2QT92 unreviewed LGSN H2QTE2 unreviewed PM20D2 H2QUI1 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation H2QXB7 unreviewed PGM5 H2QXZ2 unreviewed CERCAM H2QYT3 unreviewed DMRTC1B H2QZ04 unreviewed CAPN6 Lacks conserved residue(s) required for the propagation of feature annotation H2QZ83 unreviewed PASD1 H2R4I1 unreviewed UBE2NL Lacks conserved residue(s) required for the propagation of feature annotation H2R4J2 unreviewed TFDP3 H2R8A3 unreviewed MST1 Lacks conserved residue(s) required for the propagation of feature annotation H2R8X1 unreviewed DPYSL5 H2R8X9 unreviewed MCOLN2 H2R9G5 unreviewed RNASE12 H2RBT2 unreviewed KCNU1 H2RC76 unreviewed DPYSL3 H2RDF9 unreviewed CRMP1 H3BPP0 unreviewed CHRFAM7A H3GLV7 unreviewed H3GYH6 unreviewed H3H9Z6 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation H7BX60 unreviewed Pot1b H8WH83 unreviewed H9ESG7 unreviewed CHPF H9ET42 unreviewed GPD1L H9EV66 unreviewed NT5C3L H9FSX3 unreviewed RPS6KC1 H9FU42 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation H9FWM2 unreviewed PANK4 H9G0X2 unreviewed SEMA7A Lacks conserved residue(s) required for the propagation of feature annotation H9G7I2 unreviewed azin2 H9G7V9 unreviewed CYFIP2 H9GDN0 unreviewed DPYSL5 H9GEX6 unreviewed H9GGP1 unreviewed H9GJP7 unreviewed FAM20A H9GLF8 unreviewed FRMD7 H9GU70 unreviewed AEBP1 Lacks conserved residue(s) required for the propagation of feature annotation H9H4A5 unreviewed DPYSL4 H9H6T5 unreviewed H9H8A3 unreviewed CHPF H9IUR0 reviewed EXD1 H9Z4K5 unreviewed AHCYL1 I0B6F4 reviewed The mature peptide is linear as it lacks the C-terminal Asp/Asn residue required for cyclization I0B6F5 reviewed The mature peptide is linear as it lacks the C-terminal Asp/Asn residue required for cyclization I0FPP6 unreviewed DPYSL2 I1GPF8 unreviewed LOC100821654 I1GPK6 unreviewed LOC100831205 I1GUX9 unreviewed LOC100826007 I1GYQ4 unreviewed LOC100836318 I1HAF9 unreviewed LOC100845936 I1HM55 unreviewed LOC100826961 I1HUG5 unreviewed LOC100832631 I1I0T8 unreviewed LOC100830956 I1IEE9 unreviewed LOC100836261 Lacks conserved residue(s) required for the propagation of feature annotation I1IPJ0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation I1ITR8 unreviewed LOC100833618 I1KUN6 unreviewed LOC100811722 I1L1Z6 unreviewed I1L3K8 unreviewed LOC100804454 I1L5W0 unreviewed LOC100790693 I1LDW4 unreviewed LOC100526938 I1LYL5 unreviewed LOC100787443 I1ME71 unreviewed LOC100499694 I1RB03 reviewed GT2 I2CY64 unreviewed DPYSL3 I3L5P4 unreviewed THNSL2 I3LA44 unreviewed NRBP1 I3LBY7 unreviewed DPEP3 Lacks conserved residue(s) required for the propagation of feature annotation I3LC14 unreviewed ADAMTSL2 Lacks conserved residue(s) required for the propagation of feature annotation I3LE93 unreviewed PRSS37 Lacks conserved residue(s) required for the propagation of feature annotation I3LGX9 unreviewed CHPF I3LPY8 unreviewed PANK4 I3PB36 reviewed CNL I3PB37 reviewed 4CL1 I7LRF5 unreviewed Fam20a J3JQX9 unreviewed asip2b Lacks conserved residue(s) required for the propagation of feature annotation J9JI72 unreviewed Pasd1 J9S2W1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation J9T303 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation J9VYM3 unreviewed K3XF65 unreviewed LOC101774499 K3XXR8 unreviewed LOC101786580 K3XYS0 unreviewed LOC101786186 K3Y6B8 unreviewed LOC101753596 K3ZA72 unreviewed LOC101756867 K3ZA75 unreviewed LOC101771046 K3ZAC7 unreviewed LOC101785896 K3ZE47 unreviewed K4AE73 unreviewed LOC101756232 K4AF26 unreviewed K4AP85 unreviewed LOC101757555 K4BAZ1 unreviewed LOC101245015 K4D3V7 reviewed UGT76E1 K4D422 reviewed UGT73C4 K7BQR6 unreviewed DPYSL2 K7CKT2 unreviewed FAM20A K7CYD7 unreviewed GPD1L K7KX52 unreviewed K7LFQ4 unreviewed K7N3M0 unreviewed LOC100779924 K7N4U8 unreviewed LOC100789699 K7N4U9 unreviewed LOC100815745 K7TMF4 unreviewed LOC100277871 L0N7N1 reviewed Kif14 L0T864 reviewed fpg2 May be non-functional, contains only the C-terminal section of a formamidopyrimidine-DNA glycosylase and has no detectable DNA-binding activity L7N6F8 reviewed L7VIN3 reviewed L7YAI7 reviewed b4gat1 M0R3L8 unreviewed Gba1 M0R3R8 unreviewed Eps8l3 M0R3Z8 unreviewed Rbm15 M0R5Z2 unreviewed Frat2 M0R685 unreviewed Ulk4 M0R6Y6 unreviewed Tmem120b M0R716 unreviewed Tbc1d16 M0R7T2 unreviewed Alkbh7 M0R7Z9 reviewed Plin5 M0R8W9 unreviewed Cd177 M0R9B3 unreviewed Sppl2c M0RAP5 unreviewed Sbf1 M0RB87 unreviewed Gdf2 M0RBE8 unreviewed Was M0RBV7 unreviewed Jarid2 Lacks conserved residue(s) required for the propagation of feature annotation M0RC17 unreviewed Chl1 Lacks conserved residue(s) required for the propagation of feature annotation M0RDC9 unreviewed Exosc1 M0ZVZ8 unreviewed LOC102597478 M0ZWM9 unreviewed LOC102605143 M1AZ03 unreviewed LOC102601785 M1B6A6 unreviewed LOC102593444 M1BEH2 unreviewed LOC102604710 M1BYQ1 unreviewed LOC102597199 M1C1F9 unreviewed LOC102597305 M1C722 unreviewed LOC102601050 M1C8V7 unreviewed M1CE87 unreviewed LOC102579624 M1CUF2 unreviewed M1ZJW4 unreviewed IL1RL1 Lacks conserved residue(s) required for the propagation of feature annotation M4CIB7 unreviewed M4CZK4 unreviewed M4D552 unreviewed M4DCB4 unreviewed M4DD04 unreviewed M4DH66 unreviewed M4DK07 unreviewed M4DMM4 unreviewed M4DTL0 unreviewed M4E6Z5 unreviewed M4EFA8 unreviewed M4EHL9 unreviewed M4EQ40 unreviewed M4ETS8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation M4F5H6 unreviewed M4F5X1 unreviewed M4FA41 unreviewed M5VX01 unreviewed M5VZV4 unreviewed M5W6T9 unreviewed M5WAV8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation M5WAW3 unreviewed M5WHJ8 unreviewed M5WVS9 unreviewed M5XFV3 unreviewed M9MRE4 unreviewed dachs M9ND56 unreviewed IP3K1 M9NDI3 unreviewed Snx6 M9NDN2 unreviewed PGRP-LC M9NDY2 unreviewed PGRP-LE M9NDY9 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation M9NE86 unreviewed CG15769 Lacks conserved residue(s) required for the propagation of feature annotation M9NEE3 unreviewed Acp76A M9NEV9 unreviewed Dmel\CG43321 M9NEZ2 unreviewed sdt M9NFA6 unreviewed EHR M9NG38 unreviewed sdt M9NH46 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation M9PAZ4 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation M9PBM3 unreviewed Atg4a M9PCE5 unreviewed Hml Lacks conserved residue(s) required for the propagation of feature annotation M9PCU0 unreviewed ninaC Lacks conserved residue(s) required for the propagation of feature annotation M9PDD9 unreviewed drl M9PEM5 unreviewed PGRP-LA M9PER2 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation M9PGW1 unreviewed Kap3 M9PH86 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation M9PHX1 unreviewed CG9059 M9PHZ2 unreviewed ect M9PJD0 unreviewed sdt O00159 reviewed MYO1C Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1) O00165 reviewed HAX1 O00180 reviewed KCNK1 O00182 reviewed LGALS9 O00206 reviewed TLR4 In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (PubMed:28334607). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (PubMed:28334607). Based on this, it is unlikely that Toll-like receptors have NADase activity O00291 reviewed HIP1 O00429 reviewed DNM1L O00469 reviewed PLOD2 O00512 reviewed BCL9 It is uncertain whether Met-1 or Met-27 is the initiator O00623 reviewed PEX12 O01404 reviewed Phm O01579 unreviewed azin-1 O01761 reviewed unc-89 In contrast to obscurins in other species, unlikely to have serine/threonine kinase activity as both protein kinase domains are predicted to be catalytically inactive. The Lys residue involved in ATP binding is not conserved in both kinase domains O02372 reviewed lush According to some authors (PubMed:14759510) it does not bind to ethanol. They suggest that the avoidance triggered by high concentration of alcohols may be due to impurities, such as phthalates or structurally related compounds, present as contaminants in the ethanol used. They conclude that it may be directly and strictly required for the perception of an odorant, rather than being involved only in modulating the response to ethanol O02649 reviewed Hsp60A O02675 reviewed DPYSL2 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure O04151 reviewed CRT1 O04204 reviewed RPP0A O04331 reviewed PHB3 O04425 reviewed FCA O04492 reviewed DRB1 O04630 reviewed THRRS O04658 reviewed NOP5-1 O04834 reviewed SAR1A O04983 reviewed CAC2 O06159 reviewed bkdC O06319 reviewed cut4 O06553 reviewed Was originally thought to be an FMN-dependent pyridoxine 5'-phosphate oxidase || FMN and PLP are seen in the crystal structures published in PubMed:16239726, however, the enzyme does not bind these compounds in vitro, and the complexes obtained in the crystal structures may be the result of weak FMN/PLP binding that is stabilized by the crystal lattice O06793 reviewed cut1 O07427 reviewed O07806 unreviewed O08553 reviewed Dpysl2 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure O08573 reviewed Lgals9 O08575 reviewed Eya2 O08590 reviewed Aoc3 O08617 reviewed Ptprr O08625 reviewed Syt10 O08629 reviewed Trim28 O08644 reviewed Ephb6 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. In addition, lacks kinase activity in vitro (PubMed:8761299). Despite the lack of kinase activity, can bind ATP (By similarity) O08653 reviewed Tep1 O08680 reviewed Epha3 O08697 reviewed Arl2 O08835 reviewed Syt11 O08878 reviewed Gper1 O08962 reviewed Kcnh2 O09053 reviewed Wrn O09171 reviewed Bhmt O13022 reviewed dpysl3-a Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure O13310 reviewed orb6 O13610 reviewed fcf1 O13759 reviewed csx1 O13799 reviewed O13801 reviewed dri1 O13818 reviewed O13879 reviewed O13918 reviewed zhf1 O13919 reviewed pst2 O13953 reviewed alp13 O14002 reviewed mak2 O14021 reviewed prw1 O14065 reviewed O14091 reviewed sut1 O14115 reviewed ptl2 O14133 reviewed O14249 reviewed O14258 reviewed ace2 O14265 reviewed vma13 O14304 reviewed O14313 reviewed pmp20 O14399 reviewed ubl1 O14526 reviewed FCHO1 O14531 reviewed DPYSL4 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure O14638 reviewed ENPP3 O14653 reviewed GOSR2 O14678 reviewed ABCD4 Originally proposed to be a peroxisomal protein (PubMed:9266848). Recent studies have suggested its localization to the endoplasmic reticulum and within the lysosome (PubMed:27456980) O14713 reviewed ITGB1BP1 O14734 reviewed ACOT8 O14745 reviewed NHERF1 O14880 reviewed MGST3 Initially it was postulated to be an endoplasmic reticulum membrane protein, but later it was proved by combined proteomic analysis, APEX fingerprinting and confocal and electron microscopy to be localized to the mitochondrion instead O14966 reviewed RAB29 O14974 reviewed PPP1R12A O15078 reviewed CEP290 O15197 reviewed EPHB6 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. In addition, lacks kinase activity in vitro (PubMed:34431498, PubMed:9207182). Despite the lack of kinase activity, can bind ATP (PubMed:34431498) O15247 reviewed CLIC2 O15260 reviewed SURF4 O15379 reviewed HDAC3 O15455 reviewed TLR3 O15529 reviewed GPR42 The sequence shown in this entry differs from the translation of the reference genome assembly (GRCh38/hg38) due to a missense variant at position 174 in the reference genome, that results in the loss of response to short chain fatty acids, including propionate O15537 reviewed RS1 O16262 reviewed nipi-4 O16810 reviewed Orc1 O17731 reviewed O18373 reviewed Sps1 The conserved active site Cys (or selenocysteine) residue in position 49 is replaced by an Arg and therefore the protein lacks selenide-dependent monoselenophosphate synthetase activity O18515 unreviewed O18965 reviewed KCNH1 O22151 reviewed GOS12 O22263 reviewed PDIL2-1 O22703 reviewed RZ1B O22788 reviewed PXG3 O22899 reviewed O22914 reviewed CP12-1 O22922 reviewed U2B'' O23016 reviewed KAB1 O23138 reviewed CYTC-1 O23144 reviewed PPI1 O23166 reviewed HCF164 The active site contains a CEVC motif which differs from the conserved CGPC motif O23239 reviewed UBC17 O23244 reviewed PAP25 O23247 reviewed EMB1027 O23249 reviewed CKS1 O23255 reviewed SAHH1 O23300 reviewed ECI3 O23404 reviewed PPDK O23515 reviewed RPL15A O23617 reviewed TPS5 O23654 reviewed VHA-A O24457 reviewed PDH-E1 ALPHA O24520 reviewed AHB1 O26981 reviewed O30434 reviewed entP O31666 reviewed mtnW O32042 reviewed dtd Could be the product of a pseudogene. The lack of an initiation codon prevents translation of this gene, in agreement with the observation that D-Tyr-tRNA(Tyr) deacylase activity cannot be detected in some strains of B.subtilis (PubMed:24097941, PubMed:25441601, PubMed:4292198). Mutagenesis to restore the start codon (in strain NCIB 3610, the parent of the fully sequenced 168) confers resistance to D-Tyr (PubMed:24097941) O32215 reviewed helD O32504 reviewed pprA O35095 reviewed Ncdn O35098 reviewed Dpysl4 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure O35129 reviewed Phb2 O35165 reviewed Gosr2 O35217 reviewed Minpp1 O35251 reviewed Vegfd O35303 reviewed Dnm1l O35405 reviewed Pld3 Exhibits no phospholipase activity, despite the fact it belongs to the phospholipase D family and the presence of two HKD motifs O35460 reviewed Angpt1 O35485 reviewed Vegfb O35509 reviewed Rab11b O35601 reviewed Fyb1 O35607 reviewed Bmpr2 O35632 reviewed Hyal2 O35646 reviewed Capn6 O35671 reviewed Itgb1bp1 O35704 reviewed Sptlc1 O35740 reviewed Cited2 O35744 reviewed Chil3 O35793 reviewed Grem1 O35799 reviewed Hfe O35845 unreviewed Smarca4 O35923 reviewed Brca2 O35945 reviewed Aldh1a7 O35977 unreviewed Gfra2 O36030 reviewed O42131 reviewed TOP2B O42223 unreviewed TWT1 O42486 unreviewed Bcat O42844 reviewed cmk2 O42874 reviewed peg1 O42890 reviewed cao2 O42980 reviewed nep1 O43029 reviewed fap1 O43089 reviewed cbp6 O43315 reviewed AQP9 O43320 reviewed FGF16 O43390 reviewed HNRNPR O43432 reviewed EIF4G3 O43435 reviewed TBX1 O43505 reviewed B4GAT1 Was initially characterized as a beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine, able to initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans (PubMed:9405606). However, it was later shown that it acts as a beta-1,4-glucuronyltransferase (PubMed:25279697, PubMed:25279699) O43813 reviewed LANCL1 O43820 reviewed HYAL3 O43865 reviewed AHCYL1 In spite of its similarity with AHCY, which catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, recombinant AHCYL1 expressed in bacteria shows no hydrolase activity, nor does it affect the enzyme activity of AHCY O45551 reviewed ife-1 O46084 reviewed Pgam5 O46094 unreviewed Ocrl O46108 reviewed Lip3 O46522 reviewed CYBB O48538 reviewed RBOHF Was originally called RBOHA O48549 reviewed RPS6A O48722 reviewed HO2 Lacks the conserved His residue involved in heme iron binding and essential for heme oxygenase activity. Its enzyme activity is therefore unsure O48737 reviewed O49010 unreviewed SBP1 Lacks conserved residue(s) required for the propagation of feature annotation O49203 reviewed NDPK3 PubMed:14736920 demonstrates a thylakoid lumen location, while PubMed:14671022 shows a mitochondrial location O49213 reviewed GER1 O49485 reviewed PGDH1 O49506 reviewed GLO5 O49552 reviewed DDB1B O49561 reviewed GA2OX8 O49623 reviewed SAL2 O49627 reviewed ISU1 O49839 reviewed PBL2 O49840 reviewed PBL3 O49879 reviewed HCR9-0 O50008 reviewed MS1 O50039 reviewed OTC O53581 reviewed cut6 O54689 reviewed Ccr6 O54715 reviewed Atp6ap1 O54767 reviewed Zp2 O54769 reviewed Fgf16 O54902 reviewed Slc11a2 The capacity to transport copper ions remains controversial O54935 reviewed XRCC1 O54980 reviewed Syngr2 O54982 reviewed Kcnu1 O55012 reviewed Picalm O55082 reviewed Ptpn20 O55099 reviewed Aurkb O55112 reviewed Aff2 O55207 reviewed Synj2 O55222 reviewed Ilk Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein O55232 reviewed Hcrt O55233 reviewed Cer1 O55242 reviewed Sigmar1 O57341 reviewed fgf8a O57428 reviewed has-rs Probably inactive because it lacks critical residues conserved in other family members, including an Asp in the motif DSDT, which is NSDI in has-rs, and an Arg residue in the motif QXXRW, which is QQTPW in has-rs. Also inactive in the functional assays of PubMed:9442026 O59010 reviewed O59702 reviewed clr6 O59739 reviewed bag102 O59819 reviewed O59858 reviewed gpx1 Was originally thought to be a glutathione peroxidase (PubMed:10455235), but functions as an atypical 2-Cys peroxiredoxin using thioredoxin as reducing power instead (PubMed:18162174) O59923 reviewed SIR2 O59932 reviewed ght4 O59945 reviewed fim1 O60066 reviewed abh1 O60093 reviewed O60094 reviewed pol5 Was originally thought to belong to the DNA polymerase type-B family based on conserved motifs (PubMed:12093911). Has later been shown to be unrelated to B class DNA polymerases (PubMed:12695662) O60145 reviewed ppk23 O60260 reviewed PRKN O60293 reviewed ZFC3H1 O60341 reviewed KDM1A Was previously reported to interact with ASXL1. However, this publication has been retracted || Conflicting results exist regarding the H3K4 demethylase activity of the neuron-specific isoforms (LSD1+8a). One study PubMed:20164337 reports that this isoform retains H3K4 demethylase activity. In contrast, PubMed:25684206. argues that the neuron-specific isoform is reprogrammed (via cofactors such as SVIL and others) to preferentially target H3K9me2, showing little to no H3K4me1/2 demethylase activity. The discrepancies appear to come from differences in assay type, complex composition, substrates (peptides vs nucleosomes), cofactors, post-translational states O60353 reviewed FZD6 O60447 reviewed EVI5 O60499 reviewed STX10 O60563 reviewed CCNT1 O60565 reviewed GREM1 O60841 reviewed EIF5B O60883 reviewed GPR37L1 Has been reported to act as a receptor for prosaposin (PSAP) (PubMed:23690594). However, it has also been shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor (PubMed:27072655) O60931 reviewed CTNS O61120 unreviewed O61847 reviewed cdk-2 O61938 unreviewed srbc-66 O61955 reviewed ife-3 O62512 unreviewed eelo-2 O62787 reviewed SLC2A3 O64503 reviewed UTR1 O64530 reviewed STR1 O64722 reviewed ZHD3 O64740 reviewed SEC13B O64765 reviewed GLCNAC1PUT2 O64812 reviewed SRK2J O64879 reviewed BGLU15 O65202 reviewed ACX1 O65282 reviewed CPN20 O65381 reviewed RUB3 O65541 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation O65569 reviewed RPS11B O65660 reviewed PLAT1 O65688 reviewed SQS2 Does not show squalene synthase activity O66678 reviewed ctc O67108 reviewed gyrA O67137 reviewed gyrB O69679 unreviewed murT Lacks conserved residue(s) required for the propagation of feature annotation O69728 unreviewed O70127 reviewed Abcb11 O70173 reviewed Pik3c2g O70191 reviewed Atf5 O70230 reviewed Znf143 Was reported to play a role in chromatin looping together with CTCF (PubMed:33397967). However, it was later shown that the antiboby against ZNF143 crossreacts with CTCF and that ZNF143 is not involved in chromatin looping (PubMed:39708803, PubMed:39708805) O70305 reviewed Atxn2 O70326 reviewed Grem1 O70354 reviewed Ca11 O70473 reviewed AKR1A1 O70582 reviewed Alox12b O70594 reviewed Slc22a5 O70595 reviewed Abcb6 To date, the intracellular localization of ABCB6 is a matter of debate, with conflicting reports suggesting mitochondrial or endolysosomal localization, therefore questioning the requirement of ABCB6 in the mitochondrial import of porphyrins O71037 reviewed ERVK-19 O73864 reviewed wnt11 O74191 reviewed fkbp39 O74315 reviewed amo1 O74424 reviewed nup211 O74500 reviewed nup60 O74504 reviewed duc1 O74539 reviewed mak3 O74756 reviewed chs2 O74793 reviewed O74805 reviewed myo51 O74818 reviewed ecm14 Lacks the conserved Glu residue in position 458 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates O74832 reviewed pet127 O74854 reviewed pof6 O74955 reviewed O74986 reviewed ctp1 O75001 reviewed mcm7 O75022 reviewed LILRB3 O75093 reviewed SLIT1 O75094 reviewed SLIT3 O75150 reviewed RNF40 O75197 reviewed LRP5 O75326 reviewed SEMA7A O75339 reviewed CILP Was originally thought to constitute the ATP pyrophosphatase enzyme (NTPPH). However, it was later shown (PubMed:12746903, PubMed:15864306) that it is not the case O75344 reviewed FKBP6 Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity O75367 reviewed MACROH2A1 In contrast to other Macro-domain containing proteins, lacks ADP-ribose glycohydrolase activity O75473 reviewed LGR5 O75493 reviewed CA11 O75558 reviewed STX11 O75581 reviewed LRP6 O75665 reviewed OFD1 O75674 reviewed TOM1L1 O75695 reviewed RP2 O75795 reviewed UGT2B17 O75821 reviewed EIF3G O75955 reviewed FLOT1 O76093 reviewed FGF18 O76324 reviewed dco O76865 unreviewed Ugalt O77059 reviewed cry O77283 unreviewed ec Lacks conserved residue(s) required for the propagation of feature annotation O80536 reviewed PIF3 O80626 reviewed RPL35B O80713 reviewed SDR3a O80738 reviewed TPS10 O80774 unreviewed O80803 reviewed XTH17 O80831 reviewed BAM7 O81062 reviewed SPP O81077 reviewed CYP707A2 O81126 reviewed RSZ22 O81153 reviewed PBC2 O81270 reviewed PXG1 O81299 unreviewed O81433 reviewed ISU3 O81482 reviewed O81643 reviewed VLN1 O81644 reviewed VLN2 O82290 reviewed SKL2 SKL2 does not possess shikimate kinase activity in vitro probably because it lacks the conserved active sites and substrate binding sites of the shikimate kinase family O82345 reviewed BAG6 O82491 reviewed SPT16 Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity O82504 reviewed RDR2 O82514 reviewed ADK1 O82597 reviewed PPA5 O82656 reviewed PTP1 O82662 reviewed O82663 reviewed SDH1-1 O88177 reviewed Pex12 O88182 reviewed Fgf18 O88279 reviewed Slit1 O88280 reviewed Slit3 O88286 reviewed Wiz O88393 reviewed Tgfbr3 O88501 reviewed Capn6 O88513 reviewed Gmnn O88658 reviewed Kif1b O88662 reviewed Emp2 O88705 reviewed Hcn3 O88737 reviewed Bsn O88767 reviewed Park7 Glyoxalase activity has been reported. It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed O88797 reviewed Dab2 O88904 reviewed Hipk1 O88990 reviewed Actn3 O89016 reviewed Abcd4 Originally proposed to be a peroxisomal protein (By similarity). Recent studies have suggested its localization to the endoplasmic reticulum and within the lysosome (By similarity) O89042 reviewed Pola1 O89093 reviewed Ccl20 O89112 reviewed Lancl1 O93437 unreviewed cmdr1 O94326 reviewed pir2 O94387 reviewed O94404 reviewed O94418 reviewed mug87 O94436 reviewed tfg3 O94445 reviewed suv3 O94468 reviewed mag2 As a homolog of the DNA glycosidase mag1, has been identified to be an alkylbase DNA glycosidase (PubMed:18270439). However, further studies revealed that it did not have any DNA glycosylase activity for alkylated bases due to the loss of the active site 'Ser-56', and was rather involved in structural sculpting DNA to facilitate damage signaling (PubMed:23245849, PubMed:23273506) O94488 reviewed mto1 O94526 reviewed ptn1 O94529 reviewed pob3 O94603 reviewed jhd1 In contrast to other JHDM1 histone demethylases, it lacks the iron catalytic His in position 370 which is replaced by a Tyr residue and has no histone demethylase activity in vitro (PubMed:16362057). It therefore may not be functional in vivo O94625 reviewed spj1 O94642 reviewed tad2 O94663 reviewed dot2 O94726 reviewed mnl1 O94745 reviewed mas2 Does not seem to have protease activity as it lacks the zinc-binding site O94759 reviewed TRPM2 The isolated nudix hydrolase domain was shown to have low catalytic activity with ADP-ribose upon heterologous expression (PubMed:11385575). However, a more recent publication demonstrates that the nudix hydrolase domain lacks enzyme activity and suggests that spontaneous degradation of the substrate underlies the previously reported low activity (PubMed:27383051) O94761 reviewed RECQL4 O94812 reviewed BAIAP3 O94813 reviewed SLIT2 Was previously reported to silence the attractive effect of NTN1. However, the article has been retracted because certain micrograph and Western blot images were duplicated, leading to concerns about the findings in the manuscript O94886 reviewed TMEM63A O94892 reviewed ZNF432 O95057 reviewed DIRAS1 O95248 reviewed SBF1 Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 1422 in the dsPTPase catalytic loop and does not have phosphatase activity (PubMed:9537414). The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases O95251 reviewed KAT7 O95259 reviewed KCNH1 O95292 reviewed VAPB O95342 reviewed ABCB11 O95400 reviewed CD2BP2 O95455 reviewed TGDS Was initially thought to have dTDP-D-glucose 4,6-dehydratase activity, based on its similarity with bacterial enzymes involved in the synthesis of rhamnose during bacterial cell wall formation. However, it was later shown to have UTP-glucose 4,6-dehydratase activity (PubMed:40836090) O95718 reviewed ESRRB O95727 reviewed CRTAM O95759 reviewed TBC1D8 O95813 reviewed CER1 O95816 reviewed BAG2 O95858 reviewed TSPAN15 O95859 reviewed TSPAN12 O95865 reviewed DDAH2 Was originally thought to be a dimethylarginine dimethylaminohydrolase (with EC:3.5.3.18) able to hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) (PubMed:10493931). However, a recent multicentre study has shown that DDAH2 does not have dimethylarginine dimethylaminohydrolase activity by using different approaches (PubMed:21493890, PubMed:37296100) O95870 reviewed ABHD16A O95970 reviewed LGI1 Was originally reported to be down-regulated in neuroblastoma cells and may play a role in the control of neuroblastoma cell survival. However, the corresponding article has been retracted O95994 reviewed AGR2 O96008 reviewed TOMM40 O97177 reviewed E(spl)m2-BFM P00184 reviewed Cyp1a1 P00185 reviewed Cyp1a1 P00493 reviewed Hprt1 P00519 reviewed ABL1 P00560 reviewed PGK1 P00592 reviewed PLA2G1B P00669 reviewed SRN P00684 reviewed Rnase1 P00750 reviewed PLAT P01012 reviewed SERPINB14 P01015 reviewed Agt P01127 reviewed PDGFB P01137 reviewed TGFB1 P01143 reviewed Crh P01194 reviewed Pomc P01241 reviewed GH1 P01244 reviewed Gh1 P01257 reviewed Calca P01286 reviewed GHRH P01591 reviewed JCHAIN P01889 reviewed HLA-B P02319 reviewed Prm1 P02340 reviewed Tp53 It is uncertain whether Met-1 or Met-4 is the initiator P02470 reviewed CRYAA P02489 reviewed CRYAA P02521 reviewed ASL1 P02647 reviewed APOA1 P02650 reviewed Apoe P02741 reviewed CRP P02786 reviewed TFRC P02843 reviewed Yp1 P02844 reviewed Yp2 P02886 reviewed dscA-1 The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2 P04049 reviewed RAF1 P04055 reviewed Pla2g1b P04062 reviewed GBA1 P04085 reviewed PDGFA P04156 reviewed PRNP An isoform was shown to be localized to both the cytoplasm and the nucleus and to be sumoylated with SUMO1 (PubMed:19059915). The article has later been withdrawn by the authors P04202 reviewed Tgfb1 P04439 reviewed HLA-A P04551 reviewed cdc2 P04629 reviewed NTRK1 P04639 reviewed Apoa1 P04778 reviewed LHCB1.3 P04839 reviewed CYBB Originally thought to be the voltage-gated proton channel responsible for the proton efflux that compensates for the charge movement across the cell membrane (PubMed:10578014). But recent data do not support this idea (PubMed:11477065, PubMed:12034764). DeCoursey et al, show that the selectivity and gating kinetics of voltage-gated proton channels are identical regardless of whether CYBB is present in human myeloid leukemia cells line lacking or expressing CYBB (PubMed:11477065). In addition, no proton currents is detected in COS-7 cells transfected with CYBB (PubMed:12034764) P04897 reviewed Gnai2 P04925 reviewed Prnp P05067 reviewed APP Was reported to bind TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (PubMed:19225519). This work was later retracted (PubMed:38110576) P05153 reviewed PCK1 P05197 reviewed Eef2 P05305 reviewed EDN1 P05371 reviewed Clu P05466 reviewed P05556 reviewed ITGB1 P05622 reviewed Pdgfrb P05712 reviewed Rab2a P05943 reviewed S100a10 P05990 reviewed r P06133 reviewed UGT2B4 UGT2B4 has been previously described as an enzyme named UGT2B11. However the name UGT2B11 has now been reused for another human protein (see AC O75310) P06281 reviewed Ren1 P06525 reviewed ADH1 P06607 reviewed Yp3 P06610 reviewed btuE Part of the btuCED operon, and was originally thought to participate in the transport of vitamin B12, but it was shown later that it plays no essential role in vitamin B12 transport P06685 reviewed Atp1a1 P06730 reviewed EIF4E Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145). However, it was later shown that the major phosphorylation site is Ser-209 (By similarity) P06746 reviewed POLB P06766 reviewed Polb P06797 reviewed Ctsl P06857 reviewed PNLIPRP1 Was originally thought to be the pancreatic lipase, but has been shown to have very low or undetectable lipase activity in vitro P07026 reviewed sdiA P07140 reviewed Ace P07154 reviewed Ctsl P07207 reviewed N P07350 reviewed Ifna6 P07483 reviewed Fabp3 P07527 reviewed wee1 P07799 reviewed top1 P07895 reviewed Sod2 P07978 reviewed Prm2 P07998 reviewed RNASE1 P08030 reviewed Aprt P08101 reviewed Fcgr2 P08171 reviewed Est-6 P08226 reviewed Apoe P08337 reviewed mutT P08424 reviewed Ren1 P08430 reviewed Ugt1a6 P08476 reviewed INHBA P08516 reviewed Cyp4a10 P08529 reviewed rpl14 P08582 reviewed MELTF P08592 reviewed App P08645 reviewed Rap1 P08646 reviewed Ras85D P08699 reviewed Lgals3 P08735 reviewed GAPC1 P08752 reviewed Gnai2 P08753 reviewed Gnai3 P08775 reviewed Polr2a P09055 reviewed Itgb1 P09233 reviewed SODA.4 P09234 reviewed SNRPC P09382 reviewed LGALS1 P09486 reviewed SPARC P09606 reviewed Glul P09671 reviewed Sod2 P09875 reviewed Ugt2b1 P09884 reviewed POLA1 P09916 reviewed Ghrh P09957 reviewed y P09958 reviewed FURIN P0A0D2 reviewed ant P0AAR3 reviewed ybaK P0AER0 reviewed glpF P0C024 reviewed NUDT7 P0C0K6 reviewed EPHB6 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. In addition, lacks kinase activity in vitro. Despite the lack of kinase activity, can bind ATP P0C0K7 reviewed Ephb6 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. In addition, lacks kinase activity in vitro. Despite the lack of kinase activity, can bind ATP P0C0S5 reviewed H2AZ1 P0C0S6 reviewed H2az1 P0C0S7 reviewed H2az1 P0C5B6 reviewed 4CLL4 P0C5W1 reviewed Map1s P0C5X8 reviewed Ttyh1 P0C6A1 reviewed Slc2a7 According to some reports, mediates transmembrane transport of glucose and fructose (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity) P0C865 reviewed Mapk7 P0C8M2 reviewed P0CE46 reviewed Slc30a8 P0CH38 reviewed Fbxo45 P0CI71 reviewed P0CJ42 reviewed TPS02 Could be the product of a pseudogene. In strain cv. Columbia, a naturally frameshift at position 65 results in a truncated TPS02 protein. Lacks the conserved active sites, suggesting that it has no terpenoid synthase activity. A complete sequence for TPS02 can be found in strain cv. Wassilewskija (AC P0CJ43) P0CJ47 reviewed ACT3 P0CJ48 reviewed LHCB1.1 P0DH91 reviewed ARF2-B P0DH95 reviewed CAM1 P0DH96 reviewed CAM4 P0DH97 reviewed CAM2 P0DH98 reviewed CAM3 P0DH99 reviewed A1 P0DI03 reviewed P0DI04 reviewed P0DI06 reviewed P0DKB4 reviewed l3hypdh P0DKC3 reviewed PGLP1A P0DKC4 reviewed PGLP1B P0DKL4 reviewed SAP130A P0DKL6 reviewed SAP130B P0DMW0 reviewed Hspa1a P0DMW2 reviewed NLRP2B Likely derived from retrogene insertion of an NLRP2/NLRP7-like gene, it was originally considered a pseudogene. However, it turns out to be functional and under purifying selection P0DO44 reviewed ATP6 P0DO45 reviewed ATP6 P0DO54 reviewed TIP1-2 P10118 reviewed Prm1 P10153 reviewed RNASE2 P10361 reviewed Tp53 P10443 reviewed dnaE P10536 reviewed Rab1b P10567 reviewed unc-15 P10600 reviewed TGFB3 P10633 reviewed Cyp2d1 P10676 reviewed ninaC P10688 reviewed Plcd1 P10809 reviewed HSPD1 P10909 reviewed CLU Isoform 4 has been previously detected in cytosol and in the nuclei of apoptotic cells and promoted apoptosis following irradiation (PubMed:12551933). However the nuclear localization and apoptosis promotion has not been confirmed in other cell types (PubMed:24073260) P10922 reviewed H1-0 P11029 reviewed ACAC P11137 reviewed MAP2 P11169 reviewed SLC2A3 P11247 reviewed Mpo P11248 reviewed Prm2 P11345 reviewed Raf1 P11388 reviewed TOP2A P11415 reviewed CRYZ P11490 reviewed PETE P11574 reviewed VHA-B1 P11762 reviewed Lgals1 P11859 reviewed Agt P11980 reviewed Pkm P12003 reviewed VCL P12019 reviewed pdsA P12270 reviewed TPR P12644 reviewed BMP4 P12724 reviewed RNASE3 P12814 reviewed ACTN1 P12881 reviewed Prosalpha6 P12919 reviewed PDGFB P13085 reviewed Pthlh P13207 reviewed Edn3 P13234 reviewed Camk4 P13385 reviewed CRIPTO P13599 reviewed Fcgrt P13705 reviewed Msh3 P13796 reviewed LCP1 P13852 reviewed Prnp P13866 reviewed SLC5A1 P13945 reviewed ADRB3 P14138 reviewed EDN3 P14207 reviewed FOLR2 P14210 reviewed HGF Has lost two of the three essential catalytic residues and so probably has no enzymatic activity P14270 reviewed Pde4d P14550 reviewed AKR1A1 P14576 reviewed Srp54 P14625 reviewed HSP90B1 Was originally thought to function in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092). However, it was later shown that hyperglycosylated form of HSP90B1 is a target of ERAD and is not involved in ERAD itself (PubMed:18264092) P14646 reviewed Pde4b P14735 reviewed IDE P14891 reviewed HMG1 P14902 reviewed IDO1 P14923 reviewed JUP P15056 reviewed BRAF P15146 reviewed Map2 P15207 reviewed Ar P15257 reviewed Hnf1a P15311 reviewed EZR P15382 reviewed KCNE1 P15383 reviewed Kcne1 P15384 reviewed Kcna3 P15387 reviewed Kcnb1 P15865 reviewed H1-4 P15880 reviewed RPS2 P15975 reviewed Usp53 P16045 reviewed Lgals1 Was originally thought to originate from human P16047 reviewed TGFB3 P16110 reviewed Lgals3 P16153 reviewed tcdE P16310 reviewed Ghr P16520 reviewed GNB3 P16550 reviewed APA1 P16568 reviewed BicD P16612 reviewed Vegfa P16662 reviewed UGT2B7 P16869 reviewed fhuE P16975 reviewed Sparc P17066 reviewed HSPA6 P17094 reviewed ARP1 P17125 reviewed Tgfb3 P17246 reviewed Tgfb1 P17256 reviewed Mvk P17336 reviewed Cat P17480 reviewed UBTF P17562 reviewed SAM2 P17697 reviewed CLU P17745 reviewed TUFA P17764 reviewed Acat1 P17813 reviewed ENG P17844 reviewed DDX5 DDX5 was reported to be a transcriptional coactivator of ESR1. However, this study has been retracted due to concerns of image manipulation P17931 reviewed LGALS3 P17945 reviewed Hgf Has lost two of the three essential catalytic residues and so probably has no enzymatic activity P18053 reviewed Prosalpha3 P18054 reviewed ALOX12 P18206 reviewed VCL P18242 reviewed Ctsd P18293 reviewed Npr1 P18858 reviewed LIG1 P18901 reviewed Drd1 P18910 reviewed Npr1 P19020 reviewed Drd3 P19024 reviewed Kcna5 P19099 reviewed CYP11B2 P19224 reviewed UGT1A6 P19456 reviewed AHA2 P19544 reviewed WT1 P19637 reviewed Plat P19735 reviewed PRP6 P19804 reviewed Nme2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) P19809 reviewed eae P20033 reviewed Pdgfa P20042 reviewed EIF2S2 P20115 reviewed CSY4 P20393 reviewed NR1D1 P20478 reviewed Gs2 P20585 reviewed MSH3 P20809 reviewed IL11 P20823 reviewed HNF1A P21128 reviewed ENDOU Was originally (PubMed:2350438) thought to be a serine protease. However, PubMed:18936097 showed it is not the case P21238 reviewed CPN60A1 The Cpn60 chaperonin complex was previously shown to be required for folding of the NAD(P)H-quinone oxidoreductase subunit ndhH. However the corresponding paper has been retracted due to fraudulent image manipulation of some of the data P21240 reviewed CPN60B1 The Cpn60 chaperonin complex was previously shown to be required for folding of the NAD(P)H-quinone oxidoreductase subunit ndhH. However the corresponding paper has been retracted due to fraudulent image manipulation of some of the data P21275 reviewed Bmp4 P21276 reviewed FSD1 P21278 reviewed Gna11 P21439 reviewed ABCB4 P21440 reviewed Abcb4 P21555 reviewed Npy1r P21675 reviewed TAF1 P21860 reviewed ERBB3 P22002 reviewed Cacna1c P22108 reviewed APA2 P22288 reviewed Gch1 P22301 reviewed IL10 P22310 reviewed UGT1A4 P22388 reviewed Edn1 P22392 reviewed NME2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (PubMed:11121025, PubMed:11694515). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (PubMed:11121025). However, this nuclease activity has not been confirmed (PubMed:19435876) P22455 reviewed FGFR4 An additional N-terminally truncated cytoplasmic isoform was previously reported to exist. However, the paper was subsequently retracted due to concerns regarding duplication of panels in some figures P22725 reviewed Wnt5a A palmitoylation site was proposed at Cys-104, but it was later shown that this cysteine is engaged in a disulfide bond P22748 reviewed CA4 P22769 reviewed Prosalpha4 P22858 reviewed Pthlh P22893 reviewed Zfp36 P22953 reviewed HSP70-1 P22987 reviewed kin1 P23142 reviewed FBLN1 P23284 reviewed PPIB It is uncertain whether Met-1 or Met-9 is the initiator P23299 reviewed Kcne1 P23377 reviewed Furin P23396 reviewed RPS3 P23470 reviewed PTPRG P23645 reviewed bib P23654 reviewed Nrt P23763 reviewed VAMP1 P23798 reviewed Pcgf2 P24057 reviewed ASL1 P24268 reviewed Ctsd P24368 reviewed Ppib It is uncertain whether Met-1 or Met-9 is the initiator P24387 reviewed CRHBP P24388 reviewed Crhbp P24485 reviewed Cd53 P24534 reviewed EEF1B2 P24928 reviewed POLR2A The paper showing an interaction with CCNL2 was retracted due to suspected data duplication that affected the interaction data P25054 reviewed APC P25070 reviewed CML24 Although assigned as a calmodulin family member by Ref.10, it only contains EF-hand domains P25099 reviewed Adora1 P25205 reviewed MCM3 P25323 reviewed mlkA P25473 reviewed CLU P25519 reviewed hflX P25697 reviewed P25722 reviewed Hs2st Was originally thought to be SD P25819 reviewed CAT2 P25856 reviewed GAPA1 P25857 reviewed GAPB P25858 reviewed GAPC1 P25977 reviewed Ubtf P26012 reviewed ITGB8 P26040 reviewed Ezr P26255 reviewed Adrb3 P26270 reviewed Rpn8 P26342 reviewed Tgfbr3 P26359 reviewed msh3 P26651 reviewed ZFP36 P26684 reviewed Ednra P26715 reviewed KLRC1 P26801 reviewed Cebpg P26927 reviewed MST1 Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack protease activity P26928 reviewed Mst1 The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity P27040 reviewed Acvr2b P27144 reviewed AK4 Some studies have failed to detect adenylate kinase activity (PubMed:11485571, PubMed:19130895). However, kinase activity has been demonstrated in a number of other studies (PubMed:19766732, PubMed:23416111) P27169 reviewed PON1 P27216 reviewed ANXA13 P27375 reviewed yjaZ Was originally thought to be a heat shock protein. However upon further examination the original mutants do not have a deletion in this gene (PubMed:16980444) P27450 reviewed CST Was originally (PubMed:1851993) reported to be a connexin and to contain transmembrane domains. PubMed:8400879 authors have assigned that this is not a connexin, but rather a protein kinase P27574 reviewed pyp1 P27605 reviewed Hprt1 P27661 reviewed H2ax P27697 reviewed COQ8 Able to autophosphorylate in cis in vitro. This activity may not be relevant in vivo and only reflects in vitro conditions. Probably does not act as a protein kinase as it is unable to act in trans (PubMed:27499294) || Was originally (PubMed:1648478) isolated as a multicopy suppressor of a yeast strain harboring a mutation in a cytochrome b translational activator (cbs2-223). But more recently it has been shown (PubMed:15063807) that a tRNA(Trp) gene located downstream of COQ8 mediates suppression of the cbs2-223 mutation. The inability of COQ8 to suppress the cbs2-223 allele in multicopy indicates it may not be a chaperone as previously reported P27788 reviewed FDX3 P27824 reviewed CANX P27952 reviewed Rps2 P28023 reviewed Dctn1 P28159 reviewed Su(H) Despite some similarity with the 'phage' integrase family, PubMed:7958912 showed that it has no recombinase activity P28568 reviewed SLC2A3 P28576 reviewed Pdgfa P28750 reviewed exu P29066 reviewed Arrb1 P29067 reviewed Arrb2 P29089 reviewed Agtr1b P29197 reviewed CPN60 P29319 reviewed Epha3 P29352 reviewed Ptpn22 P29402 reviewed CNX1 P29411 reviewed Ak3 P29456 reviewed Il10 P29458 reviewed mcm4 P29477 reviewed Nos2 P29595 reviewed Nedd8 P29755 reviewed Agtr1b P29972 reviewed AQP1 P29975 reviewed Aqp1 P29993 reviewed Itpr P30040 reviewed ERP29 P30728 reviewed Drd3 P30793 reviewed GCH1 P30922 reviewed CHI3L1 Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity P30958 reviewed mfd P30988 reviewed CALCR P31146 reviewed CORO1A P31167 reviewed AAC1 P31168 reviewed COR47 P31232 reviewed Tagln P31240 reviewed Pdgfb P31414 reviewed AVP1 P31450 reviewed glvG Could be the product of a pseudogene. Lacks the C-terminal half of the catalytic domain found in other members of this family. This truncated polypeptide does not display phospho-alpha- or phospho-beta-glucosidase activity (PubMed:9209025) P31482 reviewed Pla2g2a P31681 reviewed groEL1 P31977 reviewed Ezr P32037 reviewed Slc2a3 P32198 reviewed Cpt1a P32214 reviewed Calcr P32266 reviewed MGM1 P32300 reviewed Oprd1 P32301 reviewed Glp1r P32372 reviewed rad4 P32586 reviewed pyp2 P32849 reviewed RAD5 P33076 reviewed CIITA P33309 reviewed DOM34 The Dom34-Hbs1 complex was initially thought to mediate endonucleolytic cleavage of the mRNA to release non-functional ribosomes and degrade damaged mRNAs. DOM34 was reported to have endoribonuclease activity (PubMed:16554824, PubMed:17889667). However, it was later shown that it is not the case (PubMed:19420139) P33438 reviewed Glt P33487 reviewed ERABP1 Analysis of new null mutants leads to the conclusion that plants do not need ABP1 for auxin signaling and for their growth and development under normal growth conditions P33533 reviewed Oprd1 P33609 reviewed Pola1 P33993 reviewed MCM7 P34007 reviewed PDGFA P34208 reviewed chk1 P34227 reviewed PRX1 P34788 reviewed RPS18A P34791 reviewed CYP20-3 P34901 reviewed Sdc4 P34925 reviewed RYK Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. A chimeric receptor consisting of the extracellular domain of NTRK1/TRKA fused to the transmembrane and cytoplasmic domains of RYK is catalytically inactive (PubMed:10454588). Does not bind ATP (PubMed:24107129, PubMed:32619402) P35233 reviewed Ptpn2 P35237 reviewed SERPINB6 P35286 reviewed Rab13 P35292 reviewed Rab17 P35353 reviewed Crhr1 P35400 reviewed Grm7 P35415 reviewed Prm P35436 reviewed Grin2a P35439 reviewed Grin1 P35462 reviewed DRD3 P35465 reviewed Pak1 P35559 reviewed Ide P35565 reviewed Canx P35569 reviewed Irs1 P35570 reviewed Irs1 P35739 reviewed Ntrk1 P36222 reviewed CHI3L1 Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity P36268 reviewed GGT2P P36397 reviewed ARF1 P36404 reviewed ARL2 P36405 reviewed ARL3 P36537 reviewed UGT2B10 P36639 reviewed NUDT1 The role in cancer cell survival is under debate. Was originally considered to play a role as a sanitizing enzyme for oxidized nucleotide pools, and thus important for the survival of cancer cells (PubMed:24695224, PubMed:24695225). A later study indicates that NUDT1 plays a redundant role in eliminating oxidized nucleotides and that it is not essential for cancer cell proliferation and survival (PubMed:28679043) P36776 reviewed LONP1 P36894 reviewed BMPR1A P36895 reviewed Bmpr1a P36897 reviewed TGFBR1 P36972 reviewed Aprt P37023 reviewed ACVRL1 P37090 reviewed Scnn1b P37091 reviewed Scnn1g P37172 reviewed Acvr1 P37173 reviewed TGFBR2 P37377 reviewed Snca P37804 reviewed Tagln P37840 reviewed SNCA P37913 reviewed Lig1 P37996 reviewed Arl3 P38013 reviewed AHP1 Biochemical and mutational analysis assigned Cys-120 as the resolving cysteine (C(R)) (PubMed:9888818). However, crystal structures showed that Cys-120 is deeply buried within the protein and revealed formation of a disulfide bond between the peroxidatic cysteine Cys-62 and the therefore more likely C(R) Cys-31 (PubMed:22474296, Ref.23) P38094 reviewed fluG P38438 reviewed Tgfbr2 P38445 reviewed Acvr2b P38557 reviewed TUBG1 P38558 reviewed TUBG2 P38666 reviewed RPL24B P38811 reviewed TRA1 P38836 reviewed ECM14 Lacks the conserved Glu residue in position 391 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates P38852 reviewed LIN1 P39207 reviewed NDK1 P39210 reviewed MPV17 P39451 reviewed adhP P40235 reviewed hhp1 P40236 reviewed hhp2 P40301 reviewed Prosalpha2 P40304 reviewed Prosbeta6 P40383 reviewed exo2 P40553 reviewed DOT5 P40749 reviewed Syt4 P40793 reviewed Cdc42 P40997 reviewed ceg1 P40999 reviewed pmt1 Was originally thought not to have cytosine-5 methyltransferase activity, and this was attributed to the insertion of a Ser residue between the Pro-Cys motif found at the active site of C5 MTases (PubMed:8636983). When this serine is deleted it becomes catalytically active and recognizes and methylates the sequence CC[AT]GG. This was in agreement with S.pombe lacking m5C DNA-methylation. However, it has later been shown that it has tRNA-methyltransferase activity despite this sequence variation (PubMed:23074192) P41091 reviewed EIF2S3 P41127 reviewed RPL13B P41232 reviewed P2ry2 P41233 reviewed Abca1 P41251 reviewed Slc11a1 Was initially thought to transport Mg(+2), based on its ability to promote Mg(+2) deprivation to restrict pathogen growth (PubMed:31753999). However, subsequent studies showed that it is not able to transport Mg(2+) (By similarity) || The sequence shown contains the variant Asp-169 and represents an inactive allele: it is the variant found in the inbred strains C57BL/6J and BALB/cJ (PubMed:11237855, PubMed:15202932, PubMed:31753999, PubMed:8757814, PubMed:9730978). In inbred strains, the susceptibility to infection with unrelated intracellular parasites, such as M.bovis, S.typhimurium and L.donovani is associated with the presence of an Asp in position 169 in the predicted transmembrane domain 4 (PubMed:11237855, PubMed:15202932, PubMed:31753999, PubMed:8757814, PubMed:9730978) P41376 reviewed EIF4A1 P41377 reviewed TIF4A-2 P41438 reviewed Slc19a1 It was suggested that in contrast to human, mouse Slc19a1 is not able to transport immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:31511694). However, it was also shown to have transporter activity but only at half the level as its human homolog (PubMed:36265513) P41498 reviewed Acp1 P41516 reviewed Top2a P41807 reviewed VMA13 P41838 reviewed rae1 P41893 reviewed stp1 P41917 reviewed RAN2 P42036 reviewed RPS14C P42224 reviewed STAT1 Has been shown to be mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14 which prevents phosphorylation at Tyr-701 (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question (PubMed:29858569). It has been suggested that the lack of phosphorylation may be due to sumoylation of Lys-703 (PubMed:29858569) P42530 reviewed dscE P42658 reviewed DPP6 P42659 reviewed DPP6 P42704 reviewed LRPPRC P42733 reviewed RPS11C P42748 reviewed UBC4 P42763 reviewed ERD14 P42768 reviewed WAS P42791 reviewed RPL18B P42794 reviewed RPL11B P42795 reviewed RPL11A P42798 reviewed RPS15AA P42813 reviewed RNS1 P42859 reviewed Htt P42948 reviewed SET4 P43007 reviewed SLC1A4 P43079 reviewed CPH1 P43082 reviewed HEL P43247 reviewed Msh2 P43274 reviewed H1-4 P43278 reviewed H1-0 P43297 reviewed RD21A P43299 reviewed MCM7 P43490 reviewed NAMPT P43629 reviewed KIR3DL1 P43680 reviewed Sox18 P44280 reviewed P45579 reviewed hcxA P45895 reviewed mig-22 P46011 reviewed NIT4 P46013 reviewed MKI67 Was thought to play a key role in cell proliferation, and is commonly used as a marker of cell proliferation (PubMed:21960707, PubMed:6339421). However, its primary function is uncoupled from cell proliferation: it is required to maintain mitotic chromosomes dispersed by forming a steric and electrostatic charge barrier (PubMed:27362226) P46032 reviewed NPF8.3 P46101 reviewed Dpp6 P46248 reviewed ASP5 P46286 reviewed RPL8A P46557 reviewed mnp-1 P46593 reviewed HWP1 P46638 reviewed Rab11b P46644 reviewed ASP3 P46645 reviewed ASP2 P47039 reviewed BNA3 P47199 reviewed Cryz P47742 reviewed Gabrr2 P47778 reviewed RNASE3 P47780 reviewed RNASE3 P47782 reviewed RNASE2 P47785 reviewed RNASE2 P47842 reviewed SLC2A3 P47843 reviewed SLC2A3 P47864 reviewed Aqp5 P47942 reviewed Dpysl2 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure P47967 reviewed Lgals5 P47973 reviewed Zfp36 P48148 reviewed Rho1 P48199 reviewed Crp P48284 reviewed Ca4 P48348 reviewed GRF8 P48491 reviewed CTIMC P48641 reviewed P48802 reviewed fgf3 P49134 reviewed Itgb1 P49200 reviewed RPS20A P49201 reviewed RPS23B P49204 reviewed RPS4B P49205 reviewed RPS17A P49206 reviewed RPS26A P49209 reviewed RPL9B P49211 reviewed RPL32A P49227 reviewed RPL5B P49257 reviewed LMAN1 P49268 reviewed No comparison between the natural toxin and the recombinant one has been done to attest that the results can be also attributed to the natural toxin (mode of action and disulfide bonds) P49279 reviewed SLC11A1 Was initially thought to transport Mg(+2), based on its ability to promote Mg(+2) deprivation to restrict pathogen growth (By similarity). However, subsequent studies showed that it is not able to transport Mg(2+) (PubMed:39824808) P49407 reviewed ARRB1 P49448 reviewed GLUD2 P49615 reviewed Cdk5 P49621 reviewed Dgkb P49651 reviewed P2ry1 P49688 reviewed RPS2C P49731 reviewed mcm6 P49736 reviewed MCM2 P49762 reviewed Doa P49775 reviewed HNT2 P49792 reviewed RANBP2 Despite the presence of a PPIase cyclophilin-type domain, it has probably no peptidyl-prolyl cis-trans isomerase activity P49815 reviewed TSC2 P49816 reviewed Tsc2 P49842 reviewed WHR1 Was originally reported to be a serine/threonine-protein kinase that phosphorylates CSN1S1/alpha-casein at serine/threonine residues and histones at serine residues (PubMed:9812991). Was also reported to phosphorylate NRAS at serine residues (PubMed:30712867, PubMed:9812991). However, later studies have shown that the protein does not have kinase activity and is involved in transcription-coupled nucleotide excision repair (PubMed:32531245, PubMed:32531246, PubMed:38252411, PubMed:39547228, PubMed:39547229) || There is a discrepancy about the expression of this isoform (PubMed:30712867, PubMed:32531245). At protein level, Rodriguez-Martinez et al. show that isoform 1 is not expressed in melanocyte cell lines and two commonly used human cell lines (HEK293 and HeLa) (PubMed:32531245). According to Yin et al., isoform 1 is expressed at very low levels in melanocyte cell lines and human primary melanocytes (PubMed:30712867) P49893 reviewed wnt11b PubMed:11159911 show a lack of role in heart induction but PubMed:12167861 show a role in heart formation; the discrepancy may be due to duplication of Xenopus wnt11 genes P49903 reviewed SEPHS1 P49916 reviewed LIG3 P49952 reviewed Wt1 P50232 reviewed Syt4 P50245 reviewed AhcyL2 Although it belongs to the adenosylhomocysteinase family, recombinant mouse homolog AHCYL1 expressed in bacteria shows no hydrolase activity, suggesting that Drosophila AhcyL2 may also lack this activity P50318 reviewed P50543 reviewed S100a11 P50578 reviewed AKR1A1 P50750 reviewed CDK9 P50883 reviewed RPL12A P51111 reviewed Htt P51153 reviewed RAB13 P51407 reviewed RPP2A P51413 reviewed RPL17B P51414 reviewed RPL26A P51419 reviewed RPL27C P51422 reviewed RPL35AD P51530 reviewed DNA2 P51569 reviewed Gla P51570 reviewed GALK1 P51577 reviewed P2rx4 P51587 reviewed BRCA2 P51635 reviewed Akr1a1 P51665 reviewed PSMD7 P51809 reviewed VAMP7 P51816 reviewed AFF2 P51818 reviewed HSP90-3 P51865 reviewed Cripto P52164 reviewed Max P52287 reviewed Gnb3 P52298 reviewed NCBP2 P52299 reviewed ncbp2 P52580 reviewed IRL P52624 reviewed Upp1 P52649 reviewed CYBB P52701 reviewed MSH6 P52747 reviewed ZNF143 Was reported to play a role in chromatin looping together with CTCF (PubMed:25645053, PubMed:38206813). However, it was later shown that the antiboby against ZNF143 crossreacts with CTCF and that ZNF143 is not involved in chromatin looping (PubMed:39708803) P52803 reviewed EFNA5 P52890 reviewed atf1 P53368 reviewed Nudt1 P53369 reviewed Nudt1 P53405 reviewed isl1 P53488 reviewed ACTR2 P53568 reviewed Cebpg P53589 reviewed sucg-1 P53590 reviewed SUCLG2 P53602 reviewed MVD Was originally thought to be located in the peroxisome (PubMed:11108725). However, was later shown to be cytosolic (PubMed:14972328) P53675 reviewed CLTCL1 P53767 reviewed Flt1 P53781 reviewed ZFP36 P53790 reviewed Slc5a1 P53817 reviewed Plaat3 P53960 reviewed Conflicting data shows that it is not able to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala) in trans (PubMed:14663147). Another paper shows that this protein can edit mischarged Ser-tRNA(Ala) but not Gly-tRNA(Ala) in trans (PubMed:20010690). Experiments are not well detailed in either paper P53996 reviewed Cnbp P54150 reviewed MSR4 P54275 reviewed Msh2 P54282 reviewed Cacna1a P54315 reviewed PNLIPRP1 Was originally thought to be the pancreatic lipase, but has been shown to have very low or undetectable lipase activity in vitro P54316 reviewed Pnliprp1 Was originally thought to be the pancreatic lipase, but has been shown to have very low or undetectable lipase activity in vitro P54359 reviewed Septin2 P54511 reviewed lipM P54824 reviewed ddx6 P54851 reviewed EMP2 Previously thought to be involved in cell migration via Src activation. The publication was retracted due to image manipulation P54855 reviewed UGT2B15 P55010 reviewed EIF5 P55034 reviewed RPN10 P55090 reviewed Ucn P55159 reviewed Pon1 P55281 reviewed Cdh17 P55868 reviewed ag1 P55899 reviewed FCGRT P55916 reviewed UCP3 P55926 reviewed Asic1 P56476 reviewed Gabrr2 P56499 reviewed Ucp3 P56501 reviewed Ucp3 P56570 reviewed ife-5 P56597 reviewed NME5 P56627 reviewed Aqp9 P56722 reviewed PTPRN Does not possess catalytic activity due to replacement of highly conserved residues in tyrosine-protein phosphatase domain P56749 reviewed CLDN12 P56962 reviewed STX17 P57044 reviewed ILK Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein P57691 reviewed RPP0C P57729 reviewed RAB38 P57742 reviewed PFD5 P57750 reviewed DRT101 P58004 reviewed SESN2 P58200 reviewed Vti1b P58252 reviewed Eef2 P58352 reviewed SLC2A3 P58965 reviewed dinB P59046 reviewed NLRP12 P59108 reviewed Cpne2 P59213 reviewed malX P59214 reviewed malX P59220 reviewed CAM7 P59223 reviewed RPS13A P59224 reviewed RPS13B P59231 reviewed RPL10AC P59259 reviewed P59282 reviewed TPPP2 P59326 reviewed Ythdf1 Was initially reported to act as a regulator of mRNA translation efficiency by promoting ribosome loading to m6A-containing mRNAs and by interacting with translation initiation factors eIF3 (EIF3A or EIF3B), thereby facilitating translation initiation (PubMed:30401835, PubMed:30728504, PubMed:30843071). These studies suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:30401835, PubMed:30728504, PubMed:30843071). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573). The effect on translation efficiency observed earlier is probably indirect (PubMed:32943573) P59536 reviewed TAS2R41 P59539 reviewed TAS2R45 P59542 reviewed TAS2R19 P59551 reviewed TAS2R60 P59692 reviewed Siva1 P59798 reviewed Selenok P59823 reviewed Il1rapl1 P59824 reviewed Il1rapl1 P59913 reviewed Pcmtd1 Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro P59941 reviewed Sirt6 P60029 reviewed IL1RAPL1 P60039 reviewed RPL7C P60040 reviewed RPL7B P60153 reviewed RNASE9 P60154 reviewed Rnase9 P60507 reviewed ERVFC1 CKS-17 sequence does not match the minimal active consensus P60509 reviewed ERVPABLB-1 The cleavage site does not match the consensus || CKS-17 sequence does not match the minimal active consensus P60570 reviewed Panx1 P60571 reviewed Panx2 P60572 reviewed Panx3 P60608 reviewed ERVFC1-1 The cleavage site does not match the consensus || CKS-17 sequence does not match the minimal active consensus || No predictable signal peptide || Truncated; premature stop codon upstream of the potential transmembrane domain P60842 reviewed EIF4A1 P60903 reviewed S100A10 P61011 reviewed SRP54 P61019 reviewed RAB2A P61106 reviewed RAB14 P61107 reviewed Rab14 P61150 reviewed Fgf12 P61160 reviewed ACTR2 P61161 reviewed Actr2 P61168 reviewed Drd2 P61169 reviewed Drd2 P61224 reviewed RAP1B P61225 reviewed RAP2B P61227 reviewed Rap2b P61282 reviewed NEDD8 P61328 reviewed FGF12 P61329 reviewed Fgf12 P61550 reviewed ERVS71-1 The cleavage site does not match the consensus || CKS-17 sequence does not match the minimal active consensus P61565 reviewed ERVK-21 P61812 reviewed TGFB2 In contrast to other members of the family, does not contain a R-G-D cell attachment site motif that mediates binding to integrins and promotes release of Latency-associated peptide (LAP) chain from TGF-beta-2 P62495 reviewed ETF1 P62629 reviewed EEF1A1 P62630 reviewed Eef1a1 P62632 reviewed Eef1a2 P62633 reviewed CNBP P62634 reviewed Cnbp P62820 reviewed RAB1A P62826 reviewed RAN P62828 reviewed Ran P62909 reviewed Rps3 P63025 reviewed Vamp3 P63026 reviewed VAMP2 P63027 reviewed VAMP2 A structure of a fragment of this protein in complex with the catalytic domain of C.botulinum neurotoxin type B (BoNT/B, botB) was reported; because of the lack of clear and continuous electron density for the VAMP2 peptide in the complex structure, the paper was retracted (PubMed:10932255, PubMed:19578378). However this protein is a substrate for BoNT/B (PubMed:22289120, PubMed:7803399) P63038 reviewed Hspd1 P63039 reviewed Hspd1 P63045 reviewed Vamp2 P63058 reviewed Thra P63059 reviewed Thra P63074 reviewed Eif4e P64483 reviewed proXp-y P68107 reviewed FKBP1B P68209 reviewed P68403 reviewed Prkcb P69566 reviewed Ranbp9 P70120 reviewed Hes5 P70158 reviewed Smpdl3a P70232 reviewed Chl1 P70315 reviewed Was P70339 reviewed Frat1 P70351 reviewed Ezh1 P70371 reviewed Terf1 P70377 reviewed Fgf13 P70379 reviewed Fgf14 P70425 reviewed Rit2 P70478 reviewed Apc P70503 reviewed Nr0b1 P70539 reviewed Acvr1c P70550 reviewed Rab8b P70553 reviewed Slc11a1 P70618 reviewed Mapk14 P71603 unreviewed acp-1 P71741 reviewed P72758 reviewed ccmM P73304 reviewed rpsE P73505 reviewed ileS P74246 reviewed P76046 reviewed ycjX P76251 reviewed dmlA P78962 reviewed atf21 P78965 reviewed pgr1 P79065 reviewed tip1 P80201 reviewed Acvr1 P80203 reviewed Acvrl1 P80204 reviewed Tgfbr1 P81287 reviewed ANXA5 P81508 reviewed P81509 reviewed P81615 reviewed Ucn P81623 reviewed ERP29 P81795 reviewed Eif2s3 P82281 reviewed TL29 Was originally thought to be an ascorbate peroxidase (PubMed:12068123, PubMed:16034597). PubMed:19828564 fails to show any peroxidase activity associated with TL29 and demonstrates that TL29 could bind neither heme nor ascorbate. TL29 lacks the heme-binding site, the proton acceptor and the transition state stabilizer, which are conserved features of the ascorbate peroxidase P82804 reviewed Pym P82873 reviewed TOM20-2 P83088 reviewed FucTC While several publications have shown an absence of alpha1,3-fucosyltransferase activity, only production of the anti-HRP glycoprotein epitope, resulting from the addition of fucose in an alpha 1-3 linkage to the innermost GlcNAc residue of N-glycans adjacent to the peptide chain, was tested (PubMed:11382750, PubMed:16314421). Orthologs in mosquitoes and honey bees have been shown to have Lewis-type alpha1,3-fucosyltransferase activity (By similarity) P83097 reviewed Wsck Gln-626 is present instead of the conserved Asp which is expected to act as an active site proton acceptor therefore suggesting that it has no protein kinase activity P83098 reviewed Stlk P83483 reviewed P83484 reviewed P83556 reviewed Kir3dl1 P83870 reviewed Phf5a P83871 reviewed Phf5a P84080 reviewed ARF1 P84103 reviewed SRSF3 P84850 reviewed D2hgdh P84995 reviewed P85004 reviewed P85045 reviewed P85071 reviewed P85078 reviewed P85972 reviewed Vcl P86013 reviewed paenA P86093 reviewed P86164 reviewed P86165 reviewed P86292 reviewed P86453 reviewed Does not bind calcium as one of the calcium-binding sites is lost (Asp->Lys in position 48, which corresponds to 'Lys-49' in the current nomenclature) P87061 reviewed tea1 P87074 reviewed crb2 P87131 reviewed cys12 P87142 reviewed ssz1 P87147 reviewed egd2 P87154 reviewed pol2 P87176 reviewed slx8 P90520 reviewed top2mt P91615 reviewed Adhr P91645 reviewed cac P91938 reviewed Trxr1 Was originally thought to be a glutathione reductase P92208 reviewed bsk P92549 reviewed ATPA P92943 reviewed CLC-D P92947 reviewed MDAR5 P92976 reviewed SSL11 It is uncertain whether Met-1 or Met-2 is the initiator P92979 reviewed APR1 P92981 reviewed APR2 P92996 reviewed GLP5A P93655 reviewed LON1 P93819 reviewed MDH1 P93836 reviewed HPD P94040 reviewed GLP1 P94072 reviewed GER3 P94078 reviewed P94111 reviewed SSL12 P94545 reviewed mutSB P95028 unreviewed P96210 reviewed espG1 P96830 unreviewed P97333 reviewed Nrp1 P97427 reviewed Crmp1 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure P97445 reviewed Cacna1a P97478 reviewed Coq7 P97479 reviewed Myo7a Represents an unconventional myosin. This protein should not be confused with the conventional myosin-7 (MYH7) || Originally predicted to contain a coiled coil domain but proposed to contain a stable SAH domain instead P97489 reviewed Gata5 P97499 reviewed Tep1 P97583 reviewed Bdkrb1 P97605 reviewed Efna5 P97616 reviewed Adarb2 Although it is similar to the double-stranded RNA adenosine deaminases ADAR/ADAR1 and ADARB1/ADAR2 and capable of binding RNA, it lacks double-stranded RNA adenosine deaminase activity in vitro. Instead, it inhibits adenosine-to-inosine editing in vivo P97675 reviewed Enpp3 P97769 reviewed Cited1 P97884 reviewed Ccl20 P97946 reviewed Vegfd P98082 reviewed DAB2 P98158 reviewed Lrp2 P9WG65 reviewed mpt53 P9WGE9 reviewed sodC Lacks two conserved histidine residues that bind copper and zinc P9WGG5 reviewed sigG P9WGU9 reviewed lpqY P9WGY3 reviewed rraA Originally described as a SAM-dependent methyltransferase (PubMed:9634230), the crystal structure does not resemble other known SAM-dependent methyltransferases. The structure does resemble the phosphohistidine domain of several phosphotransfer system proteins. The protein does not bind S-adenosylmethionine cofactor or potential methyltransferase substrate molecules P9WGZ5 reviewed rnz Lacks two conserved zinc binding sites P9WHH7 reviewed lpdA Despite significant sequence similarity to lipoamide dehydrogenases this protein cannot catalyze the reduction of lipoyl substrates. It lacks one of two cysteine residues involved in dithiol-disulfide interchange with lipoyl substrates and a His-Glu pair involved in general acid catalysis P9WHH9 reviewed lpdC P9WHR3 reviewed hip1 P9WIA1 reviewed ptpA P9WIC3 reviewed pheA P9WID5 reviewed adoK P9WIJ1 reviewed pdxH P9WIQ7 reviewed erp P9WIS1 reviewed bkdB P9WIS3 reviewed bkdA P9WIS5 reviewed kgd Was originally annotated as sucA because of sequence similarity (PubMed:12218036, PubMed:9634230). But this protein was shown not to be able to serve as the E1 component of 2-oxoglutarate dehydrogenase (ODH) (PubMed:16045627). However, it was later shown that this protein does in fact sustain ODH activity, and requires specific activation by acetyl-CoA (PubMed:21867916) P9WIS7 reviewed dlaT P9WIU5 reviewed arfA Was originally thought to be a porin P9WJ05 reviewed P9WJD1 reviewed espF P9WJH7 reviewed ndkA P9WJM9 reviewed mshC P9WJQ3 reviewed narG P9WK15 reviewed mbtK P9WK17 reviewed glcB P9WKI3 reviewed guaB1 P9WKI5 reviewed guaB3 P9WKZ1 reviewed P9WM67 reviewed fcoT P9WMJ9 reviewed dnaK P9WN15 reviewed Despite its similarity with the trehalose-phosphate phosphatase enzymes, it does not display trehalose-phosphate phosphatase activity P9WN23 reviewed glbO P9WNC9 reviewed folP2 A histidine residue in the pterin-binding domain interferes with substrate binding, and seems to be responsible for abolishing dihydropteroate synthase activity P9WNV7 reviewed dnaJ2 P9WP01 reviewed punA P9WP39 reviewed cut3 P9WP41 reviewed cut2 P9WP43 reviewed cut7 P9WPA1 reviewed coaX P9WQ29 reviewed Q00238 reviewed Icam1 Q00535 reviewed CDK5 Q00623 reviewed Apoa1 Q00954 reviewed Scn1b Q00959 reviewed Grin2a Q00961 reviewed Grin2c Q00IB7 reviewed plekhh1 Q00M95 reviewed RHBDF2 Q01098 reviewed Grin2c Q01130 reviewed SRSF2 The paper showing an interaction with CCNL2 was retracted due to suspected data duplication that affected the interaction data Q01768 reviewed Nme2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) Q01887 reviewed Ryk Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. No kinase activity has been detected in kinase assays using the cytoplasmic domain of the protein (PubMed:1334548). Does not bind ATP (By similarity) Q01973 reviewed ROR1 The kinase domain has very low catalytic activity in vitro (PubMed:25029443). Does not bind ATP (PubMed:24107129, PubMed:32619402) Q02809 reviewed PLOD1 Q02874 reviewed Macroh2a1 Q02880 reviewed TOP2B Q02908 reviewed ELP3 The elongator complex was originally thought to play a role in transcription elongation. Was reported to display histone acetyltransferase activity and to acetylate histone H3 preferentially at 'Lys-14', and H4 preferentially at 'Lys-8' (PubMed:10445034, PubMed:11904415, PubMed:15138274). However, it was later shown that the effect on histone acetylation and chromatin regulation is indirect and that the elongator complex is primarily involved in tRNA modification (PubMed:17018299, PubMed:18986986, PubMed:21912530) Q02936 reviewed hh Q02972 reviewed CAD8 Q03062 reviewed Hes5 Q03114 reviewed Cdk5 Q03160 reviewed Grb7 Q03167 reviewed TGFBR3 Q03214 reviewed ECM5 Q03248 reviewed Upb1 The purified enzyme was shown to contain 1.8 zinc atoms per subunit, and sequence analysis was used to predict the zinc binding site (PubMed:8449931). The crystal structure of the human ortholog indicates a lack of bound zinc ions, and shows that the residues that were predicted to bind zinc are too far apart in space to form a zinc binding site (By similarity) Q03251 reviewed RBG8 Q03391 reviewed Grin2d Q03426 reviewed MVK Q03468 reviewed ERCC6 PubMed:16916636 was retracted due to image manipulations Q03509 reviewed CAM6 Q03513 reviewed ccmM Q03701 reviewed CEBPZ Q03919 reviewed RUB1 Q04206 reviewed RELA Q04344 reviewed HNT1 It is uncertain whether Met-1 or Met-15 is the initiator Q04370 reviewed PEX12 Q04371 reviewed Q04400 reviewed Adcy5 Q04573 reviewed Npy1r Q04752 reviewed NR5A1 Q04771 reviewed ACVR1 Q05028 reviewed Pdgfb Q05030 reviewed Pdgfrb Q05315 reviewed CLC Was originally thought to possess lysophospholipase activity but the absence of this activity has been shown by PubMed:11834744 Q05586 reviewed GRIN1 Q05639 reviewed EEF1A2 Q05695 reviewed L1cam Q05758 reviewed Q05996 reviewed ZP2 Q06265 reviewed EXOSC9 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q06429 reviewed ACS1 Lacks the conserved tripeptide Ser/Thr-Asn-Pro in position 205 necessary for the ACS activity Q06518 reviewed Nos2 sequence Was originally thought to originate from human but appears to be from rat Q06826 reviewed Bmp4 Q06890 reviewed Clu Q06900 unreviewed ChALK5 Q06945 reviewed SOX4 Q07098 reviewed PP2A2 Q07099 reviewed PP2A1 Q07205 reviewed Eif5 Q07257 reviewed Tgfb2 Q07258 reviewed Tgfb3 Q07448 reviewed spc Q07553 reviewed Gyc32E Q07647 reviewed Slc2a3 Q07666 reviewed KHDRBS1 Q07813 reviewed Bax Q08014 reviewed Q08048 reviewed Hgf Has lost two of the three essential catalytic residues and so probably has no enzymatic activity Q08096 reviewed RCL1 Q08112 reviewed RPS15A Q08201 reviewed Abcb4 Q08257 reviewed CRYZ Q08460 reviewed Kcnma1 Q08682 reviewed RPSaA Was originally thought to be a laminin receptor Q08770 reviewed RPL10B Q08DK7 reviewed SLC25A29 Initially, this protein was identified as a carnitine/acylcarnitine transporter (By similarity). Later, a study conducted by Palmieri and coworkers demonstrated that SLC25A29 is mainly involved in the translocation of basic amino acids (By similarity) Q08DN4 unreviewed AURKB Q08DY5 unreviewed NRBP1 Q08E21 unreviewed MLC1 Q09054 reviewed GAPC2 Q09196 reviewed cdc4 Q09693 reviewed pol4 Q09702 reviewed nrd1 Q09711 reviewed ncs1 Q09738 reviewed ubp8 Q09748 reviewed dnm1 Q09771 reviewed atf31 Q09790 reviewed aps1 Q09794 reviewed ura1 Q09822 reviewed cdc15 Q09838 reviewed prz1 Q09923 reviewed yakc Q09926 reviewed pcr1 Q09933 reviewed dis1 Q09JY9 reviewed shroom2 Q0C9B4 reviewed ecm14 Lacks the conserved Glu residue in position 485 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates Q0DKN3 reviewed VLN1 Q0E8D4 unreviewed Spn75F Q0E8E2 unreviewed SPH66 Lacks conserved residue(s) required for the propagation of feature annotation Q0E8K5 unreviewed mri Q0E8T1 unreviewed anon-SAGE:Wang-122 Q0E8Y6 unreviewed Swim Lacks conserved residue(s) required for the propagation of feature annotation Q0E908 reviewed Hil Q0E944 unreviewed Spn53F Q0GKC8 unreviewed pmaip1 Q0IGY5 unreviewed Gucy2d Q0J995 reviewed RLI1 Q0JAS4 unreviewed Q0KHU9 unreviewed sdt Q0KI07 unreviewed Dmel\CG34130 Lacks conserved residue(s) required for the propagation of feature annotation Q0KI25 unreviewed Dmel\CG4467 Q0KI58 unreviewed wrd Q0KI66 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q0KI67 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q0MVN8 reviewed CRYZ Q0P3R2 unreviewed snx15.S Q0P3U3 reviewed exd1 Q0V9W2 unreviewed crmp1 Q0VCA5 reviewed SAMHD1 Q0VCT3 reviewed TERF2IP Q0VCZ3 reviewed YTHDF2 Q0VZ68 reviewed cmdF Q0WL56 reviewed A3 Q0WL81 reviewed RNL Q0WNJ6 reviewed CHC1 Q0WQ75 reviewed VPS51 Q0WQF4 reviewed VPS53 Q0WT48 reviewed ERDJ2A Q0WUI9 reviewed TPS8 Q0WVR4 reviewed JMJ32 Q0Z8B6 reviewed hirJM79 Q0ZHH6 reviewed Atl3 Q10102 reviewed Q10103 reviewed chp1 Q10105 reviewed gcn1 Q10145 reviewed Q10154 reviewed rtf2 PubMed:19416828 concluded that rtf2 mediates replication termination at the site-specific replication barrier RTS1 and interacts with pcn1/PCNA, however PubMed:37615341 reports that this function occurs downstream of rtf2, and that the interaction may be an artifact from overexpression Q10168 reviewed nsp1 Q10214 reviewed rss1 Q10271 reviewed arb2 Q10274 reviewed teb1 Was initially reported as a potential telomeric factor as it harbors two helix-loop-helix dsDNA binding domains which are recurrently found in telomeric proteins. However, teb1 was shown to have higher affinity for the vertebrate telomere repeat, TTAGGG, than to fission yeast telomere repeats in vitro Q10281 reviewed cpc2 Q10284 reviewed sks2 Q10362 reviewed set3 Q10366 reviewed pik1 Q10426 reviewed rik1 Q10484 reviewed scs22 Q10728 reviewed Ppp1r12a Q10GJ1 reviewed RING455 Q10MR0 reviewed Q10Q07 reviewed NINJA1 Q10S82 reviewed CATC Q10SL2 unreviewed Q11119 reviewed ubp14 Q12772 reviewed SREBF2 Q12792 reviewed TWF1 Was originally thought to have protein tyrosine kinase activity Q12794 reviewed HYAL1 Q12879 reviewed GRIN2A Q12891 reviewed HYAL2 Q12959 reviewed DLG1 Q13087 reviewed PDIA2 Q13126 reviewed MTAP Q13144 reviewed EIF2B5 Q13153 reviewed PAK1 The interaction between DSCAM, PAK1 and RAC1 has beend described. This article has been withdrawn by the authors || There are data describing interaction and regulation by the product of CRIPAK, a putative single exon gene (PubMed:16278681). However, considering all available data there is no sufficient supporting evidence for the existence of such protein Q13156 reviewed RPA4 Q13308 reviewed PTK7 Q13310 reviewed PABPC4 Q13356 reviewed PPIL2 Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity due to the presence of a tyrosine instead of a tryptophan at position 389 Q13418 reviewed ILK Was originally thought to act as a serine/threonine-protein kinase (PubMed:8538749). Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein (PubMed:20005845, PubMed:21524996, PubMed:30367047) Q13426 reviewed XRCC4 Sumoylation at Lys-210 was initially reported to regulate nuclear localization and recombination efficiency of XRCC4 (PubMed:16478998). This result is however not confirmed by another study (PubMed:25934149) Q13444 reviewed ADAM15 Q13459 reviewed MYO9B Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9) Q13492 reviewed PICALM Q13510 reviewed ASAH1 Q13526 reviewed PIN1 Q13547 reviewed HDAC1 Q13637 reviewed RAB32 Q13796 reviewed SHROOM2 Q13868 reviewed EXOSC2 Q13873 reviewed BMPR2 Q14164 reviewed IKBKE Q14166 reviewed TTLL12 Although it belongs to the tubulin--tyrosine ligase family, the TTL domain lacks some of the ATP binding sites predicted to be essential for TTL activity (PubMed:23251473). Lacks tyrosine ligase activity in vitro (PubMed:23251473). Lacks glutamylation activity in vitro (By similarity). Although TTLL12 contains a potential SET-like domain in the N-terminus, it does not have lysine methyltransferase activity towards histone in vitro (PubMed:23251473) Q14194 reviewed CRMP1 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q14195 reviewed DPYSL3 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q14203 reviewed DCTN1 Q14254 reviewed FLOT2 Q14258 reviewed TRIM25 Q14451 reviewed GRB7 Q14831 reviewed GRM7 Q148E7 reviewed SNX15 Q14AZ4 unreviewed Oas1f Q15020 reviewed SART3 Q15024 reviewed EXOSC7 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q15049 reviewed MLC1 Was initially predicted to function as cation channel based on marginal amino acid sequence homology with a voltage-gated K+ channel KCNA1 Q15058 reviewed KIF14 Q15124 reviewed PGM5 Q15126 reviewed PMVK Was originally thought to be located in the peroxisome (PubMed:10191291). However, was later shown to be cytosolic (PubMed:14729858, PubMed:27052676) Q15154 reviewed PCM1 Q15170 reviewed TCEAL1 Q15256 reviewed PTPRR Q15287 reviewed RNPS1 Q15389 reviewed ANGPT1 Q15542 reviewed TAF5 Q15646 reviewed OASL This is the ortholog of mouse OASL1 Q15759 reviewed MAPK11 Q15782 reviewed CHI3L2 Lacks the conserved sequence motif DxxDxDxE that is essential for the catalytic activity of chitinases of the glycosyl hydrolase 18 family, and therefore has no chitinase activity Q15836 reviewed VAMP3 Q15843 reviewed NEDD8 Q16526 reviewed CRY1 Q16539 reviewed MAPK14 Q16555 reviewed DPYSL2 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q16566 reviewed CAMK4 Q16849 reviewed PTPRN Does not possess catalytic activity due to replacement of highly conserved residues in tyrosine-protein phosphatase domain Q17QD8 reviewed GPR37L1 Has been reported to act as a receptor for prosaposin (PSAP). However, it has also been shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor Q18086 reviewed glb-6 Q18493 reviewed Q18580 unreviewed pnk-4 Q18581 reviewed acn-1 Q185C5 reviewed eam Highly similar to the L-lysine 2,3-aminomutase. However lacks lysyl-binding Asp residues at positions 332 and 369, that are replaced by Lys and Asn residues, respectively (PubMed:17222594) Q1ESX2 unreviewed fgf21 Q1HAY7 reviewed EGF-like Q1HG60 reviewed Pif1 Q1J1N6 reviewed ddrB Q1JPD6 reviewed TUT1 Q1JQ73 reviewed elavl1-a Q1K5C5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q1K6A4 unreviewed Q1LRV9 reviewed Q1LVC2 reviewed jarid2b Q1LX52 unreviewed bida Q1LY80 reviewed tmem120b Q1LZ50 reviewed Dnmt3l Q1LZH4 unreviewed MGC140080 Q1M168 reviewed Atcay Q1MTN7 reviewed rpm1 Q1MTQ1 reviewed tea2 Q1PLL0 unreviewed hsd17b2 Q1RMW5 reviewed GRB7 Q1W617 reviewed Shroom4 Q1W9Q0 unreviewed ec Q1WIM2 reviewed Cadm2 Q1ZXJ2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q1ZZS1 reviewed LGSN Q20821 unreviewed rskd-1 Q20992 reviewed acox-3 Q21360 reviewed mak-1 Q21734 reviewed rskn-1 Q22639 reviewed vps-54 Q22888 reviewed ife-4 Q23229 reviewed xol-1 Although clearly related the GHMP kinase family as demonstrated by the 3D-structure, it lacks many conserved feature of GHMP kinases and probably does not bind ATP, suggesting that it probably does not have kinase activity Q23500 reviewed aco-1 Q23682 reviewed gcy-5 Q23972 reviewed smg Q23997 reviewed Idgf6 Lacks the typical Glu active site in position 165 that is replaced by a Gln residue, exhibits no chitinolytic activity towards either polymeric and oligomeric substrates (PubMed:18342251). Its precise function remains unclear. Strongly binds chitin even though it lacks a chitin binding domain (PubMed:18342251) Q24049 reviewed amn Q24139 reviewed comm Q24178 reviewed Prosalpha4T1 Q24325 reviewed Taf2 Q24K22 reviewed MST1 The active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack catalytic activity Q27324 reviewed drl Member of a subfamily of receptor tyrosine kinases predicted to lack kinase activity due to several amino acid substitutions in the catalytic domain that are highly conserved in other receptor tyrosine kinases. These include 350-Gln-Glu-Gly-Asn-Phe-Gly-355 (QEGNFG) instead of the Gly-Xaa-Gly-Xaa-Xaa-Gly nucleotide binding motif in subdomain I, and 486-Asp-Ser-Ala-488 (DSA) instead of the Asp-Phe-Gly canonical activation loop motif in subdomain VII. In addition, mutation of Lys-371 to Ala to produce a protein predicted to be catalytically inactive does not affect the role of the protein in axon guidance and muscle attachment (PubMed:11150355) Q27575 reviewed Prosalpha4T2 Q28283 reviewed TRIB2 Q28452 reviewed CRYZ Q28488 reviewed CRYM Q28557 reviewed CRHBP Q28705 reviewed KCNE1 Q28E73 unreviewed nedd8 Q28ER3 reviewed birc5.2 Q28FD1 reviewed akr1a1 Q28H51 reviewed birc5.1 Q29081 reviewed PMVK Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic Q29122 reviewed MYO6 Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6) || Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead Q29411 reviewed CHI3L1 Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity Q29482 reviewed CLU Q29549 reviewed CLU Q29983 reviewed MICA Q29RF4 unreviewed lgsn Q29RH7 reviewed TSPAN12 Q29RI0 reviewed COQ8A Q29RM1 reviewed SLC25A19 Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier Q2EG98 reviewed Pkd1l3 Pkd1l3 and Pkd2l1 has been initially identified as sour taste receptor in type III gustatory cells, but its role in sour taste reception is controversial (PubMed:16805797). In the circumvallate type III cells, the PKD1L3-PKD2L1 complex is proposed to form the molecular sensor responsible for acid sensing (PubMed:20406802). However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd1l3 do not show defects in sour taste perception (PubMed:20605874, PubMed:21625513). Moreover, the Pkd1l3-Pkd2l1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (PubMed:21098668) Q2EN76 reviewed NME2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) Q2FDS6 reviewed fphE Q2FFY7 reviewed Q2FXH9 reviewed Q2HIK4 reviewed PFD6 Q2HJ97 reviewed PHB2 Q2KHI9 reviewed Mcm9 Q2KIJ4 unreviewed MGC137058 Q2KIU2 reviewed PMVK Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic Q2KJ15 reviewed PDGFA Q2KMM4 reviewed Alox12b Q2LAE1 reviewed ASHH2 Q2LC84 reviewed Numb Q2M3C6 reviewed TMEM266 Q2MGK4 unreviewed Ance-3 Q2NKU9 reviewed EMP2 Q2PDP5 unreviewed Dmel\CG34041 Q2PFD7 reviewed Psd3 Q2PMX6 unreviewed Dmrtc1b Q2QLM1 unreviewed Q2QU15 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q2QWK9 reviewed Q2T9N7 reviewed LYZL4 Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity Q2T9W0 reviewed KCTD13 Q2TAG6 reviewed Nt5c3b-b Q2TGJ4 reviewed Zdhhc15 Q2TH00 reviewed ospZ Probable inactive cysteine methyltransferase. In contrast to other members of the family, has a shorter C-terminus and is unable to inhibit host cell NF-kappa-B activation (PubMed:20485572) Q2TV78 reviewed MST1L Although it belongs to the peptidase S1 family, it lacks essential His, Asp, and Ser residues of the catalytic triad and is therefore predicted to lack peptidase activity Q2TZK2 reviewed ecm14 Lacks the conserved Glu residue in position 482 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates Q2VPG9 unreviewed suclg2.L Q2YDP8 reviewed thnsl2 Q2YQA5 reviewed chpT Q2YTI5 reviewed Q30201 reviewed HFE Q304A0 reviewed MRS2-7 Q32KJ9 reviewed Arsg Q32KU2 reviewed PRSS37 Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Also lacks metal binding sites Glu in position 67 which is replaced by Asn, and Asn in position 69 which is replaced by Arg Q32L47 reviewed ERP27 Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family Q32L99 reviewed PTGR2 Q32LE6 reviewed DMRTC2 Q32NJ0 unreviewed lgr4.S Lacks conserved residue(s) required for the propagation of feature annotation Q32NR9 reviewed wdpcp Q32Q86 reviewed Cry1 Q33BN2 unreviewed LOC112293115 Q381R4 unreviewed Q381X9 reviewed CE1 Q383B3 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q383E4 unreviewed Q383U8 unreviewed Q384E6 unreviewed Q385N8 unreviewed Q38799 reviewed PDH2 Q38858 reviewed CRT2 Q38872 reviewed CPK6 Q38945 reviewed AHL Q38946 reviewed GDH2 Q38951 reviewed PP2AA3 Q389Z9 unreviewed Q38AS4 unreviewed Q38AS8 unreviewed Q38B34 unreviewed Q38BD3 unreviewed Q38BZ3 unreviewed Q38CB7 unreviewed Q38CI6 unreviewed Q38DP4 unreviewed Q38DU9 unreviewed Q39017 reviewed DGK1 Q39043 reviewed BIP2 Q39066 reviewed ECS1 Q39079 reviewed ATJ13 Q39083 reviewed DI19-1 Q39086 reviewed SD17 Q39091 reviewed KTI1 Q39108 reviewed GGR Q39141 unreviewed LHB1B2 Q39161 reviewed NIR1 Q39193 reviewed SRK2I Q39227 reviewed SMT2 Q39258 reviewed VHA-E1 Q3B7D8 reviewed Otulinl Although highly similar to the deubiquitinase OTULIN, lacks both the conserved active site residue Cys at position 136 which is replaced by an Asp residue and the conserved active site residue His at residue 347 which is replaced by a Gln residue, and does not have deubiquitinase activity Q3E846 reviewed COA6 Q3HNG7 reviewed H1-8 Q3KRB8 reviewed ARHGAP11B Although it contains a Rho-GAP domains, does not have GTPase activator activity (PubMed:25721503, PubMed:27957544). The absence of GTPase activator activity is required to promote amplification of basal progenitors (PubMed:27957544). Restoring this activity abolishes ability to promote amplification of basal progenitors during neocortex development (PubMed:27957544) Q3M5Z3 reviewed Q3MHT4 reviewed Tut1 Q3MHX5 reviewed SUCLG2 Q3MHX9 unreviewed NUDT16L1 Q3SWT1 reviewed Nabp2 Q3SWY2 reviewed ILK Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein Q3SX04 reviewed L3HYPDH Q3SX46 reviewed C1GALT1C1 Q3SXM5 reviewed HSDL1 Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity Q3SY77 reviewed UGT3A2 Q3T095 reviewed ING4 Lacks the Trp (here Arg-220), a conserved feature of the aromatic cage required for the interaction with histone H3K4me3/2 Q3T0Q4 reviewed NME2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) Q3T1I5 reviewed Srebf2 Q3T9X0 reviewed Slc2a9 High-capacity urate transporter that was first described as a fructose and glucose transporter. Also described in the literature as high-affinity and low-capacity glucose and fructose transporter (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity) Q3TA38 reviewed Tmem120b Q3TD49 reviewed Sppl2b Q3TH73 reviewed Ttyh2 According to PubMed:34824283, lacks swelling-dependent volume-regulated anion channel activity Q3TIW9 reviewed Enpp7 Q3TKT4 reviewed Smarca4 Like other proteins within the SNF2 family, they do not possess helicase activity but instead remodel chromatin via an ATP-dependent translocation mechanism Q3TPJ7 reviewed Midn Q3TSG4 reviewed Alkbh5 Q3TVP5 reviewed Otulinl Although highly similar to the deubiquitinase OTULIN, lacks the conserved active site Cys at position 136 which is replaced by an Asp residue, and does not show deubiquitinase activity Q3TY92 reviewed Mbd6 Q3TYD4 reviewed Arsg Q3U0M1 reviewed Trappc9 Q3UDF0 reviewed Slc2a6 Q3UES3 reviewed Tnks2 Q3UFY7 reviewed Nt5c3b Q3UHC7 reviewed Dab2ip Q3UHK1 reviewed Slc2a13 Q3UIK4 reviewed Mettl14 The ability of METTL14 to have catalytic activity is unclear and a number of experimental evidence suggests that it has no methyltransferase activity by itself. According to some reports, has some methyltransferase activity in vitro (PubMed:24394384). However, other studies showed that METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. 3D-structure studies showed that METTL14 contains a degenerate active site that is unable to accommodate donor and acceptor substrates Q3UIZ8 reviewed Mylk3 Q3ULJ0 reviewed Gpd1l Q3UNZ2 unreviewed Ldc1 Q3UPF5 reviewed Zc3hav1 Q3UQN2 reviewed Fcho2 Q3UU43 reviewed Chpf2 Q3V0K9 reviewed Pls1 Q3V188 reviewed Endou Q3V3E1 reviewed Ubash3a Q3ZBI5 reviewed NRROS Q3ZBM4 reviewed ITGB1BP1 Q3ZBQ0 reviewed SIRT5 Q3ZC91 reviewed SMPDL3A Q3ZCJ2 reviewed AKR1A1 Q41736 unreviewed Q41870 reviewed PIP1-1 Q42112 reviewed RPP0B Q42262 reviewed RPS3AB Q42340 reviewed RPS16C Q42342 reviewed CYTB5-E Q42418 reviewed PRF2 Q42488 unreviewed Q42525 reviewed HXK1 Q42564 reviewed APX3 Q42596 reviewed THI2.1 Q42601 reviewed CARB Q42963 reviewed PMT1 Q43247 reviewed GAPC3 Q43359 unreviewed gpc4 Q46948 reviewed yajL Was originally (Ref.1) thought to be involved in thiamine biosynthesis. However, this phenotype was probably due to an artifactual recombination event involving a portion of the adjacent thiI gene || The protein deglycation activity has been ascribed to a TRIS buffer artifact by a publication (PubMed:27903648), which has then been rebutted by clear biochemical experiments showing that DJ-1 family deglycases are bona fide deglycases (PubMed:28013050). Deglycase activity is even strengthened by a novel article that reports nucleotide deglycation activity (PubMed:28596309) Q47155 reviewed dinB Q47KB1 reviewed Q498D6 reviewed Fgfr4 Q499P3 reviewed C1galt1c1 Q499S1 unreviewed Mcoln2 Q499S9 reviewed Rhbdf1 Q49AN0 reviewed CRY2 Q49YI2 reviewed Q4FZD7 reviewed Plk5 Q4FZT0 reviewed Stoml2 Q4G033 reviewed Piwil4 Q4G056 reviewed Tdp1 Q4G3H4 reviewed chuk Q4GYB3 unreviewed Q4GYG4 unreviewed Q4H4F3 reviewed btrD Was initially thought to function as a nucleotidyltransferase (PubMed:15701005). But it was later shown that it is a deacetylase (PubMed:17226887) Q4JDL3 reviewed PTPN20 Q4KLZ0 unreviewed Vnn1 Q4KM51 reviewed Tefm Q4KM64 reviewed Jagn1 Q4KML2 reviewed cry-dash Q4KMP7 reviewed TBC1D10B Q4KMQ2 reviewed ANO6 Contains ten transmembrane regions, not eight as predicted Q4KUS2 reviewed Unc13a Q4KWZ6 reviewed MAD2L2 Q4L795 reviewed Q4LDQ3 reviewed irx5 Q4PSA3 reviewed MAP65-9 Q4PSE4 reviewed CDC20-4 Q4Q0X5 unreviewed Q4Q150 unreviewed Q4Q1J3 unreviewed Q4Q1J7 unreviewed Q4Q248 unreviewed Q4Q576 unreviewed Q4Q5E6 unreviewed Q4Q6V8 unreviewed Q4Q6X8 unreviewed Q4Q7Y6 unreviewed Q4Q813 unreviewed Q4QAR9 unreviewed Q4QBY5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q4QC38 unreviewed Q4QEZ2 unreviewed Q4QGM5 unreviewed Q4QIW6 unreviewed Q4QJJ4 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q4QQS0 reviewed Irak2 Asn-335 is present instead of the conserved Asp which is expected to be an active site residue Q4QQW4 reviewed Hdac1 Q4QR75 reviewed Exosc9 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q4QR87 reviewed Dmrtc1 Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain Q4R1J6 reviewed birc5.1-b Q4R4I0 reviewed TERF2IP Q4R501 unreviewed Q4R526 reviewed DCPH1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q4R5D9 reviewed YTHDF2 Q4R8X0 reviewed NRBP1 Q4V3D9 reviewed SSL10 Q4V7C8 reviewed Cep55 Q4V7E4 unreviewed Sox18 Q4V7F5 reviewed Pih1d1 Q4V896 reviewed Snx15 Q4V8A0 reviewed Nsmce2 Q4V8B7 reviewed Hsdl1 Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity Q4V8F3 reviewed Rhbdd1 One study reported that the protein is not localized in the mitochondrion Q4V8F9 reviewed Hsdl2 Q4V8J4 reviewed Gpat3 Q4V8P1 unreviewed Cited1 Q4V925 unreviewed badb Q4WD70 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WG64 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WKE9 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WM03 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WT37 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WXM3 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WYW1 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4WZ67 reviewed easL Q4X1U0 reviewed ecm14 Lacks the conserved Glu residue in position 490 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates Q4X202 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q4ZJI3 unreviewed mipb Q500X4 reviewed S-Lap7 Although it belongs to the peptidase M17 family, lacks the active site Lys and Arg residues and zinc binding sites, suggesting it has no aminopeptidase activity Q501L1 reviewed pm20d2 Q502K2 reviewed samhd1 Q504Q3 reviewed PAN2 Q50EX6 reviewed ODO1 Q50KA8 reviewed NME2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) Q50L39 reviewed birc5.2-a Q52KG5 reviewed Kif26a In contrast to other kinesin-like proteins, residues required for ATPase activity are missing Q52KI8 reviewed Srrm1 Q52PJ5 reviewed dpysl3 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q52PJ7 unreviewed dpysl5a Q52PJ8 unreviewed dpysl5b Q53EU6 reviewed GPAT3 Q53EZ4 reviewed CEP55 Q53GS9 reviewed USP39 Lacks the conserved His and Cys residues that are essential for the activity of de-ubiquitinating enzymes. Lacks ubiquitin C-terminal hydrolase activity (PubMed:18728397) Q54B44 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q54DU0 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q54K32 reviewed rgaA Q54N51 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q54NL4 reviewed vmp1 Q54PR9 reviewed cf60 Q54TF2 unreviewed The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q54TR1 reviewed cfaD Lacks catalytic activity, even though the active site residues are conserved Q54WC0 reviewed WHR1 Was originally reported to be a serine/threonine-protein kinase. However, later studies have shown that the protein does not have kinase activity and is involved in transcription-coupled nucleotide excision repair Q54XV3 reviewed nedd8 Q553N8 unreviewed tacc1 The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data Q553Y7 reviewed gca Q55700 reviewed ftsH2 Q55777 reviewed Q55D99 reviewed pakA Q562E7 reviewed WDR81 Q564A4 unreviewed bcl2a Q566J8 reviewed Coq8b Q568L5 reviewed akr1a1b Q569A2 reviewed Tspan12 Q569C4 reviewed Hdac10 Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates. However, histone deacetylase activity has been observed in vitro and HDAC10 has also been shown to be involved in MSH2 deacetylation Q56A35 reviewed actr2b Q56WD9 reviewed PED1 Q56WH1 reviewed TUBA3 Q56WK6 reviewed PATL1 Q56XE8 reviewed Q56XG6 reviewed RH15 Q56YN3 reviewed NADK1 Q56Z59 reviewed PATL3 Q56ZI2 reviewed PATL2 Q571I4 reviewed Prag1 Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity Q57571 reviewed Q57V03 reviewed CGM1 Q57W26 reviewed ZC3H11 Q57W28 unreviewed Q57W58 unreviewed Q57WA0 unreviewed Q57XB2 unreviewed Q57XE0 unreviewed Q57Z14 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q57ZD9 unreviewed Q57ZM2 unreviewed Q57ZU1 unreviewed Q58001 reviewed Q58085 reviewed arfC Q580J2 unreviewed Q58297 reviewed cofC Q582I5 unreviewed Q582K5 unreviewed Q582K6 unreviewed Q584D3 unreviewed Q58517 reviewed cobY Q58579 reviewed ribL Q586J4 unreviewed 25N14.205 Q587B3 unreviewed Q587D3 unreviewed Q58DT5 reviewed ELMOD3 Q58DZ9 reviewed Syndig1 Q58EM4 reviewed dcph1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q59E11 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation Q59J86 unreviewed Q59J88 unreviewed Q59J89 unreviewed Q59J90 unreviewed Q59WC5 unreviewed PHO15 Q5A1E3 reviewed CBF1 Q5A4E3 reviewed OCH1 Q5A4X5 reviewed SKN7 Q5A5R1 unreviewed GAL4 Q5A688 reviewed PMT6 Q5A766 unreviewed CAT8 Lacks conserved residue(s) required for the propagation of feature annotation Q5AF56 reviewed ADR1 Q5AHG6 reviewed SCH9 Q5AJY9 unreviewed Q5ANJ4 reviewed TEC1 Q5ANK2 unreviewed PKC1 Lacks conserved residue(s) required for the propagation of feature annotation Q5AU62 reviewed nmrA Lacks the conserved Tyr residue in position 127 in the active site triad of Ser-Tyr-Lys that is necessary for dehydrogenase activity, suggesting that it has no oxidoreductase activity Q5AVY3 unreviewed uncA Q5AYJ0 unreviewed Q5AZ18 unreviewed Q5AZV1 unreviewed Q5B011 reviewed ecm14 Lacks the conserved Glu residue in position 477 essential for carbopeptidase activity. The mature form lacks catalytic activity towards synthetic peptide substrates Q5B394 unreviewed Q5B5C5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q5BB92 unreviewed Q5BE19 unreviewed Q5BGM7 unreviewed Q5BIJ2 unreviewed wrd Q5BIK4 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q5BJP3 reviewed Ufm1 Q5BJP6 reviewed Gfm2 Q5BJQ0 reviewed Coq8a Q5BJQ5 reviewed Rit2 Q5BJY6 reviewed Amdhd2 Q5BK26 reviewed Pnpla7 It is uncertain whether Met-1 or Met-27 is the initiator Q5BK58 unreviewed Ccr6 Lacks conserved residue(s) required for the propagation of feature annotation Q5BK62 reviewed Mpv17 Q5BK65 reviewed Nrros Q5BK81 reviewed Ptgr2 Q5BKD0 reviewed Oas1b Q5BKR2 reviewed Slc9b2 Q5BL41 reviewed actr2 Q5BL43 unreviewed ahcyl2 Q5BLK4 reviewed Tut7 Q5BP97 unreviewed sppl3 Q5CD77 reviewed Tbc1d14 Q5E946 reviewed PARK7 Glyoxalase activity has been reported. It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed Q5E985 reviewed HYAL1 Q5E9T7 reviewed JADE1 Q5EA01 reviewed B4GAT1 Q5EAN7 reviewed Terf2ip Q5EAR7 unreviewed baxb Q5EAX9 reviewed tmem120b-a Q5EB68 reviewed Ak6 AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species Q5EBA8 reviewed Slc46a1 Q5EBC0 unreviewed Itih4 Q5EE04 reviewed tpr Q5EE05 reviewed ABHD5 Q5EGZ1 reviewed Ace2 Q5EUD4 unreviewed PDIL5-1 Q5F363 reviewed JARID2 Q5F383 reviewed SPPL2B Q5FVH2 reviewed Pld3 Has probably no phospholipase activity, despite the fact it belongs to the phospholipase D family and the presence of two HKD motifs Q5FVJ3 reviewed Plpp7 Q5FVK6 reviewed Cc2d1b Q5FVQ5 reviewed Lax1 Q5FVR4 reviewed Eri1 Q5FWF4 reviewed ZRANB3 Q5FWU3 reviewed Atg9a Q5FX52 reviewed Plcz1 Q5GAL7 reviewed Rnase13 Q5GAL8 reviewed Rnase12 Q5GAL9 unreviewed Rnase11 Q5GAM0 reviewed Rnase10 Q5GAM7 reviewed Rnase13 Q5GAM8 reviewed Rnase12 Q5GAM9 reviewed Rnase11 In contrast to other members of the family, lacks the conserved His active site in position 75, suggesting it is inactive Q5GAN3 reviewed RNASE13 Q5GAN4 reviewed RNASE12 Q5GAN6 reviewed RNASE10 Q5GLH2 reviewed TRIB2 Q5H9I0 reviewed TFDP3 Q5HF23 reviewed Q5HNF9 reviewed Q5HYR2 reviewed DMRTC1 Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain Q5HZE0 reviewed Slc25a29 Initially, this protein was identified as a carnitine/acylcarnitine transporter (By similarity). Later, a study conducted by Palmieri and coworkers demonstrated that SLC25A29 is mainly involved in the translocation of basic amino acids (By similarity) Q5HZE2 reviewed Tmem120a Whether TMEM120S functions as a mechanosensitive ion channel is controversial (By similarity). Several studies show that TMEM120A does not exhibit mechanosensitive channel activity and display no typical ion channel structural characteristics (By similarity). One publication, however, suggests the presence of a potential ion permeation pathway based on molecular dynamics simulation (By similarity). Its structural homology to ELOVL7, leads to suggest than TMEM120A may function as an enzyme involved in fatty acid metabolism, although its enzymatic activity and its potential substrates remain unknown (By similarity). Whether TMEM120A is an enzyme rather than an ion channel is still under debate Q5HZN8 reviewed sirt5-a Q5I0J5 reviewed Mitd1 Q5I0K7 reviewed Alg13 Q5I940 unreviewed Use1 Q5IS35 reviewed SLC25A19 Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier Q5IS50 reviewed DPP6 Q5JDJ7 reviewed Q5JXB2 reviewed UBE2NL Could be inactive as a ligase. The potential active site Cys residue in position 88 is replaced by a Ser Q5JZY3 reviewed EPHA10 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. Despite the predicted lack of kinase activity, can bind ATP (PubMed:34431498) Q5KFE6 unreviewed Q5KGM0 unreviewed Q5KK31 unreviewed Q5KND0 unreviewed Q5M731 reviewed TH1 Q5M7T9 reviewed Thnsl2 Q5M7U6 reviewed Actr2 Q5M868 reviewed Gba2 Q5M883 reviewed Clic2 Q5M8J6 unreviewed pdia2 Q5MYX0 unreviewed Oas1e Q5NKV8 unreviewed ICAM1 Q5NVC1 reviewed SLC25A19 Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier Q5NVR0 reviewed HMCES Q5PNU3 reviewed AMSH3 Q5PPI3 reviewed Gskip Q5PQL3 reviewed Sppl2b Q5PQN6 reviewed Vipas39 Q5PQQ2 reviewed Wbp11 Q5PT56 reviewed Slc10a4 Q5QJV4 unreviewed Rnase9 Q5R4K0 reviewed ACTR2 Q5R4S2 reviewed B4GAT1 Q5R4S7 reviewed CRYZ Q5R5D5 reviewed AKR1A1 Q5R5N4 reviewed METTL14 Q5R5R5 reviewed CNBP Q5R5S7 reviewed ITGB1BP1 Q5R5V4 reviewed ILK Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein Q5R608 reviewed SLC2A3 Q5R665 reviewed CA11 Q5R669 reviewed TRIB2 Q5R6G3 reviewed SIRT5 Q5R7E5 reviewed PCMTD1 Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro Q5R7K0 reviewed HSDL1 Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity Q5R806 reviewed PTGR2 Q5R8B5 reviewed TSPAN12 Q5R8Q2 reviewed KCNE1 Q5R9H4 reviewed A1CF Q5RAF0 reviewed NUDT4 Q5RB09 reviewed SLC2A9 High-capacity urate transporter that was first described as a fructose and glucose transporter. Also described in the literature as high-affinity and low-capacity glucose and fructose transporter (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity) Q5RB19 reviewed PHB2 Q5RBH9 reviewed NRBP1 Q5RBI4 reviewed ABHD5 Q5RBS4 reviewed RHBDD1 One study reported that the protein is not localized in the mitochondrion Q5RC28 reviewed L3HYPDH Q5RCK6 reviewed SYT10 Q5RCY2 reviewed NUDT5 Q5REE3 reviewed PANX1 Q5REX6 reviewed CDK5RAP3 Q5RFH3 reviewed NME2 Originnally, in addition to its DNA binding activity, some reports shown that exhibited an intrinsic nuclease activity (By similarity). Bound DNA within the nuclease hypersensitive element (NHE) III(1) region and cleaved the phosphodiester bond by transiently forming a covalent protein-DNA intermediate through a nucleophilic attack (By similarity). However, this nuclease activity has not been confirmed (By similarity) Q5RFL8 reviewed YTHDF3 Q5RGU1 reviewed coq8a Q5RGV6 unreviewed bik Q5RGV7 unreviewed bik Q5RJH2 reviewed Mctp2 Q5RJQ4 reviewed Sirt2 Q5RJR2 reviewed Twf1 Q5RK09 reviewed Eif3g Q5RK24 unreviewed Pmvk Q5RKV6 reviewed EXOSC6 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q5S260 reviewed Q5SGE0 reviewed Lrpprc Q5SV42 reviewed Serpinb1c Q5SVQ0 reviewed Kat7 Q5SZV5 reviewed Kiaa0319 Q5T0W9 reviewed SACK1B Q5T4B2 reviewed CERCAM Has no glucosyltransferase activity. Concerning beta-galactosyltransferase activity, the level of CERCAM could be too low to detect any activity when tested in transfected insect cells Q5T764 reviewed IFIT1B Q5T7P8 reviewed SYT6 Q5TA50 reviewed CPTP Q5TA89 reviewed HES5 Q5TAX3 reviewed TUT4 Q5TCH4 reviewed CYP4A22 Was originally termed CYP4A11 Q5TDP6 reviewed LGSN Q5TRG1 unreviewed 3290034 Q5TUE4 unreviewed 3291079 Lacks conserved residue(s) required for the propagation of feature annotation Q5TYP7 unreviewed ehd3 Lacks conserved residue(s) required for the propagation of feature annotation Q5U1Y0 reviewed Tmem192 Q5U1Y1 reviewed Rab34 Q5U213 unreviewed Parp4 Q5U259 reviewed elavl1-b Q5U2Q7 reviewed Etf1 Q5U2V4 reviewed Plbd1 Was shown to exhibit a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids (in vitro) (By similarity). However, phospholipase activity is not confirmed by other authors (By similarity). Furthermore, structural feature prediction does not support the idea that LYLAP is a phospholipase (By similarity) Q5U2X4 reviewed Dpep3 Q5U308 reviewed Lrrc8d Q5U309 reviewed Cercam Q5UM14 unreviewed trpa1b Q5UM15 unreviewed trpa1a Q5VRD7 reviewed CDT3 Q5VSB5 reviewed CDT1 Q5VTR2 reviewed RNF20 Q5VWQ8 reviewed DAB2IP Q5VWZ2 reviewed LYPLAL1 Q5VYK3 reviewed ECPAS Q5VYS8 reviewed TUT7 Q5W0Q7 reviewed USPL1 Q5XEN5 reviewed MBD1 Q5XH07 reviewed thnsl2 Q5XI57 reviewed Ttll10 Q5XI60 reviewed Reep6 Q5XI81 reviewed Fxr1 Q5XIB2 reviewed Cwc27 Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity Q5XIC1 reviewed Gmppa Q5XIC8 reviewed Alkbh3 Q5XIH7 reviewed Phb2 Q5XIJ1 reviewed Hmces Q5XIM5 reviewed Cdv3 Q5XIQ2 reviewed Elmod3 Q5XIQ8 unreviewed Chpf Q5XIS2 reviewed Cptp Q5XIS8 reviewed Mief1 Q5XIU2 reviewed Znf143 Q5XIZ6 reviewed gpd1l Q5XJ36 reviewed park7 Glyoxalase activity has been reported. It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed Q5XJV7 reviewed Setd5 According to a report, lacks histone methyltransferase activity and regulates chromatin by interacting with HDAC3 and PAF1 complex (PAF1C) complex (PubMed:30455454). According to another publication, displays histone methyltransferase activity and directly trimethylates 'Lys-36' of histone H3 (H3K36me3) (PubMed:31515109) Q5XKN4 reviewed Jagn1 Experiments in human confirm the importance of JAGN1 in neutrophil function with some differences. Defects in JAGN1 cause neutropenia in human, while it is not the case in mice lacking Jagn1. Mutant mice show defects in neutrophil migration and increased susceptibility to fungal infections due to defective killing capacity of neutrophil granulocytes Q5XVJ4 reviewed FAN1 Q5Y808 reviewed ROP4 Lacks the active site residue so is predicted to be catalytically inactive Q5YD48 reviewed A1cf Q5YD76 reviewed The most common activity assay for dermonecrotic toxins detects enzymatic activity by monitoring choline release from substrate. Liberation of choline from sphingomyelin (SM) or lysophosphatidylcholine (LPC) is commonly assumed to result from substrate hydrolysis, giving either ceramide-1-phosphate (C1P) or lysophosphatidic acid (LPA), respectively, as a second product. However, two studies from Lajoie and colleagues (2013 and 2015) report the observation of exclusive formation of cyclic phosphate products as second products, resulting from intramolecular transphosphatidylation. Cyclic phosphates have vastly different biological properties from their monoester counterparts, and they may be relevant to the pathology of brown spider envenomation Q5ZHN4 reviewed RP2 Q5ZIF5 reviewed TSPAN12 Q5ZIM8 unreviewed Q5ZJL9 reviewed SAMHD1 Q5ZJT1 reviewed HMCES Q5ZK35 reviewed METTL14 Q5ZK84 reviewed AKR1A1 Q5ZKF6 reviewed NT5C3B Q5ZKG3 reviewed DNA2 Q5ZKV9 reviewed VPS50 Q5ZL37 unreviewed SUCLG2 Q5ZMD4 reviewed TRIM59 Q5ZMR3 reviewed PCMTD1 Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro Q60409 reviewed KCNE1 Q60571 reviewed Crhbp Q60584 reviewed Fbxw2 Q60603 reviewed Kcnh1 Q60673 reviewed Ptprn Does not possess catalytic activity due to replacement of highly conserved residues in tyrosine-protein phosphatase domain Q60710 reviewed Samhd1 Q60755 reviewed Calcr Q60856 reviewed Oas1b Q60936 reviewed Coq8a Q60976 reviewed Jrk Q60HE7 reviewed MLC1 Q60I18 reviewed Mill1 Lacks key residues involved in peptide docking, suggesting that this is a non-classical MHC class I protein which does not play a role in antigen presentation Q60I26 reviewed Als2cl Q61066 reviewed Nr0b1 Q61093 reviewed Cybb Q61180 reviewed Scnn1a Q61288 reviewed Acvrl1 Q61362 reviewed Chi3l1 Although it belongs to the glycosyl hydrolase 18 family, Leu-149 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity Q61387 reviewed Cox7a2l Q61451 reviewed Cd53 Q61526 reviewed Erbb3 Q61559 reviewed Fcgrt Q61614 reviewed Ednra Q61616 reviewed Drd1 Q61644 reviewed Pacsin1 Q61817 reviewed Creb3 Q61909 reviewed Runx1t1 Q61G93 reviewed rol-3 Q62011 reviewed Pdpn Q62188 reviewed Dpysl3 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q62226 reviewed Shh Q62312 reviewed Tgfbr2 Q62315 reviewed Jarid2 Despite the presence of a JmjC domain, lacks the conserved residues that bind the iron cofactor, explaining the absence of histone methyltransferase activity Q62318 reviewed Trim28 Q62418 reviewed Dbnl Q62468 reviewed Vil1 Q62470 reviewed Itga3 Q62504 reviewed Spen Q62636 reviewed Rap1b Q62645 reviewed Grin2d Q62687 reviewed Slc6a18 Q62696 reviewed Dlg1 Q62746 reviewed Syt6 Q62765 reviewed Nlgn1 Q62768 reviewed Unc13a Q62769 reviewed Unc13b Q62789 reviewed Ugt2b7 Q62799 reviewed Erbb3 Q62812 reviewed Myh9 Reported to interact with SLC6A4 in its sialylated form. However, this publication was retracted due to image duplication in the figures Q62866 reviewed Slc19a1 Q62902 reviewed Lman1 Q62935 reviewed Vwf Q62950 reviewed Crmp1 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q62951 reviewed Dpysl4 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q62952 reviewed Dpysl3 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q62956 reviewed Erbb4 Q62967 reviewed Mvd Was originally thought to be located in the peroxisome (By similarity). However, was later shown to be cytosolic (PubMed:11725955) Q62975 reviewed Serpina10 Q62976 reviewed Kcnma1 Q63035 reviewed Nlrp6 Q63203 reviewed Fcgr2 Q63259 reviewed Ptprn Does not possess catalytic activity due to replacement of highly conserved residues in tyrosine-protein phosphatase domain Q63321 reviewed Plod1 Q63355 reviewed Myo1c Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1) Q63358 reviewed Myo9b Represents an unconventional myosin. This protein should not be confused with the conventional myosin-9 (MYH9) Q63372 reviewed Nrxn1 Q63470 reviewed Dyrk1a Q63472 reviewed Kcnh1 Q63481 reviewed Rab29 Q63483 unreviewed Rab38 Q63503 reviewed Nr1d1 Q63616 reviewed Vps33b Q63619 reviewed Coq7 Q63666 reviewed Vamp1 Q63673 reviewed Shh Q63690 reviewed Bax Q63744 reviewed Dlc1 Q63768 reviewed Crk Q63961 reviewed Eng Q63ZG0 reviewed tmem120b Q63ZY7 reviewed Uxt Q640K6 reviewed dpysl3-b Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q640N1 reviewed Aebp1 Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity Q64127 reviewed Trim24 Q641W3 reviewed Nufip1 Q641X7 reviewed Fbxo25 Q641Z4 reviewed Cdk9 Q641Z7 reviewed Smpdl3a Q64294 reviewed Pdpn Q64350 reviewed Eif2b5 Q64429 reviewed Cyp1b1 Q64511 reviewed Top2b Q64539 unreviewed Cyp11b3 Q64546 unreviewed Cyp11b3 Q64566 reviewed Atp2c1 Q64586 unreviewed Cyp11b3 Q64598 reviewed Q64634 reviewed Ugt1a8 Q64638 reviewed Ugt1a5 Q64678 reviewed Cyp1b1 Q64729 reviewed Tgfbr1 Q65XV2 reviewed XB3 Q66GP0 reviewed SR1IP1 Q66GP9 reviewed NOA1 Nitric oxide synthase (NOS) activity is dubious Q66GR6 reviewed WHY3 Q66H07 reviewed Fank1 Q66HA5 reviewed Cc2d1a Q66HD0 reviewed Hsp90b1 Q66HG3 reviewed Cndp1 In contrast to the human protein, it is unlikely to be secreted because it lacks the N-terminal signal sequence required for secretion. Furthermore, its activity was assessed from the soluble fraction prepared from tissues or cells not from a secreted fraction (By similarity). It could also have a slightly different substrate specificity (By similarity) Q66HG4 reviewed Galm Q66HH2 reviewed Emp2 Q66II5 reviewed l3hypdh Q66IP1 unreviewed ahcyl1.S Q66K14 reviewed TBC1D9B Q66K74 reviewed MAP1S Q66KJ9 reviewed mettl14 Q670P5 reviewed wnt11 Q675A5 reviewed Pla2g15 Q67ES2 reviewed Tas2r135 Q67YG7 reviewed SOFL1 Q680Q4 reviewed SIZ1 Q682T9 reviewed CAM5 Q68AX7 reviewed Reg4 Q68EJ0 reviewed Cyb5r4 Q68F47 reviewed sirt5-b Q68FE2 reviewed Atg9a Q68FL4 reviewed Ahcyl2 Q68FR9 reviewed Eef1d Q68FT5 reviewed Bhmt2 Q68FX9 reviewed Sirt5 Q69384 reviewed ERVK-6 Q69AB1 reviewed Txndc8 Q69T90 unreviewed Q69XJ0 reviewed SPX1 Q69Z38 reviewed Peak1 Has been the subject of controversy surrounding its catalytic capabilities. Early characterization of PEAK1 gave a weak in vitro tyrosine kinase activity. The crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft that in this conformation may deleteriously affect nucleotide binding. Furthermore PEAK1 is devoid of nucleotide binding activity, as detected by a thermal-shift assay. So it seems probable that PEAK1 is an inactive kinase Q69ZF3 reviewed Gba2 Q6A078 reviewed Cep290 Q6A4L0 reviewed Slc22a13 In contrast with human ortholog, not able to transport urate (PubMed:35144162) Q6A555 reviewed TXNDC8 Q6AV57 unreviewed Q6AWU6 reviewed HOL3 Q6AXB1 reviewed dcph1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q6AXC6 reviewed Ddx11 Q6AXL3 reviewed nrros Q6AY18 unreviewed Sar1a Q6AY19 reviewed Coq8b Q6AY57 reviewed Wipi2 Q6AY63 reviewed Nudt5 Q6AYB5 reviewed Srp54 Q6AYB8 reviewed Blzf1 Was initially thought to be a potential transcription factor, localized in the nucleus Q6AYD0 unreviewed Lrrc17 Q6AYF1 reviewed Mapkap1 Q6AYG8 unreviewed Calr3 Q6AYK1 reviewed Rnps1 Q6AYL0 reviewed Slc25a19 Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier Q6AYP5 reviewed Cadm1 Q6AYP7 reviewed Nt5c3b Q6AYT0 reviewed Cryz Q6AYT5 reviewed Dcph1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q6AYX5 reviewed Odf2 Q6AZ28 reviewed Pias2 Q6AZ61 reviewed Lmbrd1 Q6AZW2 reviewed akr1a1a Q6B337 unreviewed gipc1 Q6B345 reviewed S100a11 Q6BC88 unreviewed Ryk Lacks conserved residue(s) required for the propagation of feature annotation Q6BDR9 unreviewed Hsp25 Q6C017 unreviewed Q6C0K2 unreviewed Q6C2M4 unreviewed Q6C6K9 unreviewed Q6CES8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q6DC66 reviewed boka Q6DD88 reviewed ATL3 Q6DE21 reviewed tmem120b-b Q6DGQ8 reviewed nme5 Q6DGU4 unreviewed nedd8l Q6DHI5 reviewed sirt5 Q6DJA3 reviewed dcph1 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q6DN12 reviewed MCTP2 Q6DN14 reviewed MCTP1 Q6DRC5 reviewed uspl1 Q6FGS9 unreviewed IL10 Q6FK45 unreviewed STE12 Q6FUI3 unreviewed IRE1 Q6G8H6 reviewed Q6GFV0 reviewed Q6GL31 unreviewed nrbp1 Q6GL72 reviewed dpysl3 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q6GLB5 reviewed elavl1 Q6GLP3 unreviewed ryk.L Lacks conserved residue(s) required for the propagation of feature annotation Q6GLZ5 reviewed septin7 Q6GMC7 reviewed akr1a1 Q6GMF8 reviewed rhbdf1 Q6GQD1 reviewed cyfip2 Q6GUQ1 reviewed Egfl8 Q6ICG8 reviewed WBP2NL Q6IE81 reviewed JADE1 Q6IFT6 reviewed Ano7 Q6IMF1 reviewed Krt80 Q6IMK0 reviewed Dppa3 Q6IMP4 reviewed Panx2 Q6IND6 reviewed hmces Q6INN8 reviewed samhd1 Q6INT9 unreviewed mcoln2.L Q6IQH6 reviewed plppr1 Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved Q6IWH7 reviewed ANO7 It is uncertain whether Met-1 or Met-55 is the initiator Q6KAU8 reviewed Atg16l2 Q6LA55 reviewed Q6LZY8 reviewed rce1 Q6MG08 reviewed Abcf1 Q6MG53 reviewed Ly6g5b Q6MG55 reviewed Abhd16a Q6MG60 reviewed Ddah2 Was originally thought to be a dimethylarginine dimethylaminohydrolase (with EC:3.5.3.18) able to hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) (By similarity). However, a recent multicentre study has shown that DDAH2 does not have dimethylarginine dimethylaminohydrolase activity by using different approaches (By similarity) Q6MG84 reviewed Egfl8 Q6MWZ7 reviewed gpm2 Q6MX39 reviewed umaA Q6NKW9 reviewed Q6NL24 reviewed ECHIA Q6NLA3 unreviewed Vha100-1 Q6NLQ7 reviewed RIBA2 The substrate-binding sites for the inactive GTP cyclohydrolase-2 activity are conserved while several cofactor-binding sites are lost Q6NN85 reviewed ssh Q6NNL9 reviewed NOXY2 Q6NPF9 reviewed Q6NR03 unreviewed sdt Q6NRD5 reviewed exd1 Q6NU56 reviewed mettl14 Q6NW58 reviewed spast Q6NX65 reviewed Pdcd10 Q6NXK7 reviewed Dpp10 Gly-652 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity Q6NXT4 reviewed SLC30A6 Hydrophilic histidine residues that participate to zinc binding in transporters of the family are not conserved in SLC30A6 Q6NYB7 reviewed Rab1A Q6NYJ3 reviewed terf2ip Q6NZ22 reviewed mettl14 Q6NZP1 reviewed Zranb3 Q6NZY4 reviewed ZCCHC8 Q6P087 reviewed RPUSD3 Q6P2Q9 reviewed PRPF8 Q6P3E7 reviewed Hdac10 Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates. However, histone deacetylase activity has been observed in vitro and HDAC10 has also been shown to be involved in MSH2 deacetylation Q6P4A8 reviewed PLBD1 Was shown to exhibit a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids (in vitro) (PubMed:19019078). However, phospholipase activity is not confirmed by other authors (PubMed:40146846). Furthermore, structural feature prediction does not support the idea that LYLAP is a phospholipase (By similarity) Q6P542 reviewed Abcf1 Q6P6J4 reviewed Alkbh2 Q6P6N5 reviewed Spred3 Q6P6R7 reviewed Sgsm3 Q6P6S9 reviewed Entpd5 Q6P6W3 reviewed Hdac3 Q6P730 reviewed Dab2ip Q6P788 reviewed Atf5 Q6P7N4 reviewed hmces Q6P7S1 reviewed Asah1 Q6P824 reviewed gpd1l Q6P8J2 reviewed Sat2 Q6P9J9 reviewed Ano6 Contains ten transmembrane regions, not eight as predicted Q6P9Q6 reviewed Fkbp15 Q6PAK3 reviewed Prmt8 Q6PB66 reviewed Lrpprc Q6PBN2 reviewed aida Q6PC06 unreviewed ahcyl2b Q6PC70 unreviewed rdh8a Q6PDU1 reviewed Srsf2 Q6PHZ5 reviewed Rbm15b Q6PI26 reviewed SHQ1 Q6PI78 reviewed TMEM65 Q6PIX5 reviewed Rhbdf1 Q6PJF5 reviewed RHBDF2 Q6PXP3 reviewed SLC2A7 According to some reports, mediates transmembrane transport of glucose and fructose (PubMed:15033637, PubMed:16186102, PubMed:29548810). However, another group could not confirm transporter activity for glucose or fructose (PubMed:28083649) Q6Q629 reviewed Dpp10 Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity Q6Q6R3 reviewed Crip3 Q6Q788 reviewed APOA5 It is uncertain whether Met-1 or Met-4 is the initiator Q6Q7I7 reviewed PDGFB Q6QA69 reviewed Abhd5 Q6QDX6 unreviewed Rnase6 Q6QGW5 reviewed Sra1 Q6QMY6 reviewed Tsku Q6QN14 reviewed USP17L6P The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene Q6R3K9 reviewed YSL2 Q6RHW4 reviewed HYAL1 Q6S9E0 reviewed ZFP36 Q6SKR2 reviewed Hemk2 Q6T5F3 unreviewed Ugt1a9 Q6TGC4 reviewed PADI6 In contrast to other members of the family, does not bind Ca(2+) and is inactive in in vitro assays against standard PADIs substrate (PubMed:39286527). At the structural level, the putative active site is in an unsuitable conformation for substrate binding (PubMed:38656308, PubMed:39286527) Q6UEH3 reviewed aflT Q6USD0 unreviewed Meq Q6UX04 reviewed CWC27 Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity Q6UX06 reviewed OLFM4 Q6UX15 reviewed LAYN Q6UXH0 reviewed ANGPTL8 Initially reported to specifically promote pancreatic beta cell proliferation without insulin resistance and to promote beta cell mass expansion, thereby improving glucose tolerance (PubMed:23623304). However, this result could not be confirmed by further studies and the original paper was later retracted (PubMed:28038792). The lack of a role in beta cell proliferation was also confirmed in another study (PubMed:25417115) Q6UXS9 reviewed CASP12 The sequence shown in this entry differs from the translation of the reference genome assembly (GRCh38/hg38) due to a nonsense variant creating stop codon at position 125 in the reference genome Q6V4H6 unreviewed pdia2.L Q6VAF8 reviewed Q6VBQ5 reviewed Myadm Q6VPT6 reviewed Although it belongs to the peptidase S1 family, lacks the active site serine residue and has no protease activity Q6VY05 reviewed Dnd1 Q6W0C5 reviewed DPPA3 Q6WAY2 reviewed Plppr1 Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved Q6XR72 reviewed SLC30A10 Q6XYQ8 reviewed SYT10 Q6XZ78 reviewed FRK2 Q6Y1H2 reviewed HACD2 Shares some similarity with tyrosine phosphatase proteins but it has probably no phosphatase activity Q6YN16 reviewed HSDL2 Q6YVY6 reviewed NINJA2 Q6Z667 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q6Z668 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q6Z784 reviewed SPX2 Q6ZG85 reviewed NRAT1 Q6ZKI1 unreviewed Q6ZPI0 reviewed Jade1 Q6ZQF7 reviewed Jade2 Q6ZQJ5 reviewed Dna2 Q6ZUT3 reviewed FRMD7 Q6ZVT0 reviewed TTLL10 Two inactivating mutations in human TTLL10 (Ser-448 and Lys-467) are proposed to explain the lack of polyglycylation Q703P0 unreviewed CRH Q70EK8 reviewed USP53 Was initially reported to have no protein deubiquitinase activity due to the absence of a conserved His residue normally found 9 residues before the catalytic His (PubMed:14715245). However, it was later shown to specifically cleave 'Lys-63'-linked polyubiquitin chains composed of at least 3 ubiquitins (PubMed:39587316) Q70IB2 reviewed RNASE10 Q70IB3 reviewed RNASE10 Q70PP2 reviewed nonC According to some authors (PubMed:15965240) it may not be directly involved in NMD, as mutants do not abolish NMD. However, other data clearly show its involvement in NMD (PubMed:12881430, PubMed:16199763) Q71DJ5 reviewed LIP1 Q71M44 reviewed terf2ip Q71SG4 unreviewed CRMP1A Q71UE8 reviewed Nedd8 Q750X4 unreviewed Q754M7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q755F0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q75BU0 unreviewed Q75DK4 unreviewed Q75N34 reviewed DB3S Despite overall sequence similarity to the typical alpha class carbonic anhydrases, lacks one of the three conserved catalytic zinc-ligand histidines. The carbonate dehydratase activity of this protein is zinc-independent || It is uncertain whether the mature protein starts at position 22 or 23. The first residue of the N-terminus obtained by direct protein sequencing is 'Asn-22' according to PubMed:18303202, but it is 'Val-23' according to PubMed:15047697, PubMed:10552514 and PubMed:29423371 Q75N35 reviewed DB3L Despite overall sequence similarity to the typical alpha class carbonic anhydrases, lacks one of the three conserved catalytic zinc-ligand histidines Q75Q40 reviewed Tomm40 Q75V66 reviewed ANO5 Q75W54 reviewed EBM Q767L0 reviewed ABCF1 Q76BS1 reviewed HGF Has lost two of the three essential catalytic residues and so probably has no enzymatic activity Q76DY7 unreviewed mutS2 Q76FS5 reviewed SPS2 Q76HM9 reviewed Hyal3 Q76HN1 reviewed Hyal1 Q76NQ1 reviewed rho-5 An inactive member of the rhomboid-like family of serine proteases (PubMed:21439629). Lacks the catalytic His residue and has a Pro residue just upstream of the catalytic Ser-1160 Q78EA7 reviewed Bmpr1a Q78PB6 reviewed Ndel1 Was originally thought to function as an oligopeptidase (NUDEL-oligopeptidase or endooligopeptidase A) which could regulate peptide levels relevant to brain function Q78ZR5 reviewed Hopx Q79FA4 reviewed cut5b Q7A2R1 reviewed Q7A522 reviewed Q7JQ32 reviewed Gyc76C Q7JQF1 reviewed Oamb Q7JQT0 unreviewed Drl-2 Lacks conserved residue(s) required for the propagation of feature annotation Q7JRM5 unreviewed Q7K119 unreviewed edl Q7K141 unreviewed mRpL44 Q7K1N5 unreviewed ect Q7K1P6 unreviewed Spn100A Q7K2S9 reviewed loopin-1 Although it belongs to the peptidase M17 family, lacks the active site Arg residue and zinc binding sites, and has no aminopeptidase activity Q7K2X8 reviewed Nup44A Q7K304 unreviewed Drep2 Q7K4V4 reviewed peo Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity Q7K523 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q7K5K9 reviewed S-Lap8 Although it belongs to the peptidase M17 family, lacks the active site Lys and Arg residues and zinc binding sites, suggesting it has no aminopeptidase activity Q7K5M0 reviewed scaf Lacks the conserved residues within the catalytic triad, probably resulting in a loss of proteolytic activity Q7KRX5 unreviewed btz Q7KS11 unreviewed Ude Q7KS61 unreviewed Dmel\CG7059 Q7KSB0 unreviewed CG17837 Lacks conserved residue(s) required for the propagation of feature annotation Q7KSG0 unreviewed AhcyL2 Q7KSJ8 unreviewed Dmel\CG3505 Lacks conserved residue(s) required for the propagation of feature annotation Q7KSP6 unreviewed Sbf Q7KSU9 unreviewed c-SPH101 Lacks conserved residue(s) required for the propagation of feature annotation Q7KSZ6 unreviewed alpha-Est3 Q7KT39 unreviewed c-SPH64 Lacks conserved residue(s) required for the propagation of feature annotation Q7KT70 unreviewed Gli Q7KT71 unreviewed Dmel\CG31827 Lacks conserved residue(s) required for the propagation of feature annotation Q7KT73 unreviewed Dmel\CG18477 Lacks conserved residue(s) required for the propagation of feature annotation Q7KT83 unreviewed DS06874.6 Lacks conserved residue(s) required for the propagation of feature annotation Q7KTL6 unreviewed Nha1 Q7KTV7 unreviewed CG12562 Q7KU19 unreviewed Prosbeta4R1 Q7KUD5 reviewed Ilp5 Q7KUK0 unreviewed PUT2 Q7KUY7 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation Q7KV25 unreviewed GstT4 Q7KV84 unreviewed Dmel\CG1271 Q7KVC2 unreviewed CG32318-PA Lacks conserved residue(s) required for the propagation of feature annotation Q7KVC9 unreviewed aln Q7KVM7 unreviewed Dmel\CG33225 Lacks conserved residue(s) required for the propagation of feature annotation Q7KVT3 unreviewed sdt Q7L1T6 reviewed CYB5R4 Q7L1W4 reviewed LRRC8D Q7L266 reviewed ASRGL1 Q7L5N1 reviewed COPS6 Although related to the peptidase M67A family, it lacks the JAMM motif that probably constitutes the catalytic center and therefore it probably does not have a protease activity Q7M6Y3 reviewed Picalm Q7NEG9 reviewed rpsE Q7NF75 reviewed ileS Q7NKM1 unreviewed Q7PCJ8 reviewed SAT2 Q7PCJ9 reviewed SAT2 Q7PIR5 reviewed Tret1 Q7PLV6 unreviewed Dmel\CG40470 Q7PNL7 unreviewed 1276534 Q7PP11 unreviewed 1276224 Lacks conserved residue(s) required for the propagation of feature annotation Q7PRZ0 unreviewed 1272139 Q7PYF1 unreviewed 1281218 Q7Q3J6 unreviewed 1278045 Q7Q978 unreviewed 1275082 Q7Q9P6 unreviewed 1274798 Q7QA95 unreviewed 1274499 Q7QE71 unreviewed 1272386 Q7QF12 unreviewed 1272008 Q7QFK5 unreviewed 1271699 Lacks conserved residue(s) required for the propagation of feature annotation Q7QI46 unreviewed 1270378 Q7RTN6 reviewed STRADA Q7RTR8 reviewed TAS2R42 Q7S675 unreviewed Q7S860 reviewed cao-1 Q7SE07 unreviewed Q7SEN5 unreviewed Q7SGA4 unreviewed vma-13 Q7SGR1 unreviewed Q7SIE0 reviewed ASL1 Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase Q7SX76 unreviewed fgfrl1a Lacks conserved residue(s) required for the propagation of feature annotation Q7SXR7 unreviewed mta2 Q7SXW6 reviewed actr2a Q7SZL9 unreviewed p2rx2 Lacks conserved residue(s) required for the propagation of feature annotation Q7SZM5 unreviewed mmp2 Q7T0L4 reviewed TERF2IP Q7T1F6 unreviewed Q7T1R3 unreviewed pard3ab Q7T2B5 unreviewed ahcyl1 Q7T2C4 reviewed slc26a5 Q7T2G0 unreviewed tspan12 Q7T3G1 unreviewed gata2a Q7TMB7 reviewed Plppr4 Originally described as a 2-lysophosphatidate/LPA phosphatase (PubMed:12730698). However, following studies suggested it does not have such activity or only a residual one (PubMed:15280885). This is further supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (PubMed:15280885) Q7TME0 reviewed Plppr4 Originally described as a 2-lysophosphatidate/LPA phosphatase (PubMed:12730698). However, following studies suggested it does not have such activity or only a residual one (PubMed:19766573). This is further supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (PubMed:19766573) Q7TMF2 reviewed Eri1 Q7TN08 reviewed Dact2 Q7TN83 reviewed Syt16 Q7TN84 reviewed Syt14 Q7TNZ6 reviewed Strada Q7TP36 reviewed Shroom2 Q7TP90 reviewed Arrdc4 Q7TP91 unreviewed Surf4 Q7TQ35 reviewed PARK7 Glyoxalase activity has been reported. It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed Q7TQ40 reviewed Zic5 Q7TQN4 reviewed Rela Q7TS55 reviewed Tnfsf18 Q7TSB7 reviewed Kiss1 Q7TSE9 reviewed Hax1 Q7TSK7 reviewed Adamtsl2 Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family Q7TT51 reviewed Lgsn Q7X9I4 reviewed AERO2 Q7XA74 reviewed MVP1 Lacks the conserved active site 'GDSL' motif and has no lipase activity Q7XA87 reviewed FOLT1 Q7XCL5 unreviewed Q7XXN8 reviewed DVL16 Q7Y219 reviewed PMIR2 Q7YQL9 reviewed IL1RAPL1 Q7YQM2 reviewed AFF2 Q7YR37 reviewed ABCF1 Q7YRC6 reviewed AURKB Q7YRH3 reviewed RNASE9 Q7YTX2 unreviewed Q7YTX8 unreviewed Trehl Q7YTY8 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation Q7Z020 reviewed TrpA1 Q7Z139 reviewed hyl-2 Q7Z2D5 reviewed PLPPR4 Originally described as a 2-lysophosphatidate/LPA phosphatase (PubMed:12730698). However, following studies suggested it does not have such activity or only a residual one (PubMed:15280885). This is further supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (PubMed:15280885) Q7Z2G1 reviewed H2BW1 Q7Z2W4 reviewed ZC3HAV1 Q7Z2X4 reviewed PID1 Q7Z3C6 reviewed ATG9A Q7Z3K6 reviewed MIER3 Q7Z3Z4 reviewed PIWIL4 Q7Z443 reviewed PKD1L3 PKD1L3 and PKD2L1 has been initially identified as sour taste receptor in type III gustatory cells, but its role in sour taste reception is controversial (By similarity). Some data confirm this hypothesis in human: in 2 patients with sour ageusia that are unresponsive to sour stimuli, but show normal responses to bitter, sweet, and salty stimuli, expression of PKD1L3 and PKD2L1 is absent in the anterior part of the tongue. However, a number of experiments have recently shown that the sour taste receptor activity is probably indirect: mice lacking Pkd1l3 do not show defects in sour taste perception (By similarity). Moreover, the Pkd1l3-Pkd2l1 heteromer, when expressed in cells does not respond to acid stimuli used to evoke proton currents in taste cells (By similarity) Q7Z4T8 reviewed GALNTL5 In contrast to other members of the family, lacks the C-terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. No glycosyltransferase activity has been detected in an in vitro assay (PubMed:24398516) Q7Z5Q5 reviewed POLN Q7Z739 reviewed YTHDF3 Was initially reported to act as a regulator of mRNA translation efficiency in cooperation with YTHDF1 by binding to m6A-containing mRNAs and interacting with 40S and 60S ribosome subunits (PubMed:28106072, PubMed:28106076, PubMed:28281539). These studies suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:28106072, PubMed:28106076, PubMed:28281539). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32492408). The effect on translation efficiency observed earlier is probably indirect (PubMed:32492408) Q7Z7A4 reviewed PXK Q7ZTP2 reviewed actr2-a Q7ZVN3 unreviewed cdc14b Q7ZVW2 unreviewed fkbp4 Q7ZWS2 reviewed Nt5c3b-a Q7ZXV3 reviewed actr2-b Q7ZZY3 reviewed topbp1-B Q800K6 reviewed topbp1-A Q800Q5 reviewed tcf7l1b Q801R8 reviewed gpd1l Q803Y8 unreviewed mcoln2 Q804H7 reviewed birc5.2-b Q80IW4 unreviewed d-meq Q80IW5 unreviewed L-meq Q80SW1 reviewed Ahcyl1 In spite of its similarity with AHCY, which catalyzes the reversible hydrolysis of S-adenosyl-L-homocysteine to adenosine and homocysteine, recombinant AHCYL1 expressed in bacteria shows no hydrolase activity, nor does it affect the enzyme activity of AHCY Q80VJ2 reviewed Sra1 Q80W22 reviewed Thnsl2 Q80WQ6 reviewed Rhbdf2 Lacks serine protease activity as it lacks the catalytic Ser residue at position 692 Q80YE2 reviewed Trp53inp1 Q80YV4 reviewed Pank4 Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity Q80Z25 reviewed Ofd1 Q80Z29 reviewed Nampt Q80Z64 reviewed Nanog Q80ZF7 reviewed Rdh10 Q810S1 reviewed Mcub Q810T5 reviewed Kat7 Q811A3 reviewed Plod2 Q812D1 reviewed Psip1 Q84JA6 reviewed CESA4 Q84JU4 reviewed IBR5 Q84KJ5 reviewed CRYD Q84LB3 unreviewed Q84LB4 unreviewed Q84LM4 reviewed AARE Q84MZ4 reviewed TFIIIA Q84P23 reviewed 4CLL9 Q84P24 reviewed 4CLL6 Q84WM9 reviewed Q84WW2 reviewed PGL3 Q84XU9 unreviewed Q863K0 reviewed RNASE9 Q863K1 reviewed RNASE9 Q866X6 reviewed CA11 Q866X7 reviewed CA11 Q867B7 reviewed HGF Has lost two of the three essential catalytic residues and so probably has no enzymatic activity Q869S7 reviewed scsB Q86B58 unreviewed Dmel\CG33127 Lacks conserved residue(s) required for the propagation of feature annotation Q86BN5 unreviewed Pgaml Q86BN6 unreviewed Pgaml Q86NX0 unreviewed morgue Lacks conserved residue(s) required for the propagation of feature annotation Q86NZ6 unreviewed CG5240 Lacks conserved residue(s) required for the propagation of feature annotation Q86PE8 unreviewed Sph35 Lacks conserved residue(s) required for the propagation of feature annotation Q86TH1 reviewed ADAMTSL2 Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family Q86TI0 reviewed TBC1D1 Q86TU7 reviewed SETD3 Was initially reported to have histone methyltransferase activity and methylate 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me) (By similarity). However, this conclusion was based on mass spectrometry data wherin mass shifts were inconsistent with a bona fide methylation event (PubMed:30626964). In vitro, the protein-lysine methyltransferase activity is weak compared to the protein-histidine methyltransferase activity (PubMed:30526847) Q86U44 reviewed METTL3 Q86UE6 reviewed LRRTM1 Q86UK0 reviewed ABCA12 Q86UL3 reviewed GPAT4 Q86VW0 reviewed SESTD1 Q86WG3 reviewed ATCAY Q86Y56 reviewed DNAAF5 Q86YC3 reviewed NRROS Q86YJ6 reviewed THNSL2 Q86YL7 reviewed PDPN Q86YV5 reviewed PRAG1 Despite of the presence of a putative ATP-binding motif, this protein does not bind ATP, suggesting that it has no protein kinase activity Q8A2I1 reviewed chonabc Q8AVX5 reviewed rp2 Q8AWZ2 reviewed hoxa3a Q8BFW6 reviewed Entpd3 Q8BFZ2 reviewed Plppr1 Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved Q8BG07 reviewed Pld4 Exhibits no phospholipase activity, despite the fact it belongs to the phospholipase D family and the presence of two HKD motifs Q8BGD5 reviewed Cpt1c In contrast to its paralogs, CPT1A and CPT1B, does not have, or at very low levels, carnitine O-palmitoyltransferase activity (EC:2.3.1.21) in vivo, being unable to catalyze the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine. This is in agreement with its expression specific to neurons which is a cell-type that does not use fatty acids as fuel to any major extent and the fact that it locates to endoplasmic reticulum instead of mitochondria Q8BGE7 reviewed Trim6 Q8BGG0 reviewed Slc30a8 Q8BGH4 reviewed Reep1 Q8BGR2 reviewed Lrrc8d Q8BGV7 reviewed Kctd13 Down-regulation of Kctd13 was initially reported to cause macrocephaly due to increased proliferation (PubMed:22596160). However, it was later shown that deletion of Kctd13 does not cause any change in brain size, embryonic cell proliferation, neurogenesis, or cortical layering/migration (PubMed:29088697). Experimental conditions used may explain discrepancies. A possible explanation being that shRNAs used in the first study, may have affected off-targets Q8BHC7 reviewed Rhbdd1 One study reported that the protein is not localized in the mitochondrion Q8BHH1 reviewed Aqp11 Q8BHK3 reviewed Slc36a2 Q8BHY3 reviewed Ano1 Contains ten transmembrane regions, not eight as predicted Q8BIJ7 reviewed Rufy1 Q8BJ37 reviewed Tdp1 Q8BJQ4 reviewed Ticam2 Q8BKG3 reviewed Ptk7 Q8BKT6 reviewed Tspan12 Q8BL03 reviewed Slc25a29 Was initially proposed to transport palmitoylcarnitine, based on complementation experiments in yeast mutants lacking CRC1 and CIT2 and release of radiolabeled carnitine from mitochondria incubated with radiolabeled palmitoylcarnithine (PubMed:12882971). Later experiments done primarily with human indicate the protein functions instead as transporter of basic amino acids (By similarity) Q8BLK9 reviewed Rps6kc1 Q8BM85 reviewed Tbck Q8BMT4 reviewed Nrros Was initially thought to act as a negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense (PubMed:24739962). However, these results were based on indirect evidence and could not be confirmed by another group (PubMed:29909984). It was later shown to act as a key regulator of transforming growth factor beta-1 (TGFB1) (PubMed:29909984) Q8BRN9 reviewed Cc2d1b Q8BTX9 reviewed Hsdl1 Although it belongs to the SDR family, Phe-218 is present instead of the conserved Tyr which is an active site residue. It is therefore expected that this protein lacks oxidoreductase activity Q8BU85 reviewed Msrb3 Q8BVM4 reviewed Azin2 The human ortholog was initially reported to have ornithine or arginine decarboxylase activities, but it was later found to possess neither of them || Previously reported to be localized in the mitochondrion (PubMed:16916800). However, it was not confirmed by later reports (PubMed:18062773) Q8BVN9 reviewed Mael Q8BWC0 reviewed Tpcn2 Q8BWP8 reviewed B4gat1 Q8BYG9 reviewed Epha10 Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity. Despite the predicted lack of kinase activity, can bind ATP Q8BYK6 reviewed Ythdf3 Was initially reported to act as a regulator of mRNA translation efficiency by binding to m6A-containing mRNAs (PubMed:30591559). This study suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:32943573). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573). The effect on translation efficiency observed earlier is probably indirect (PubMed:32943573) Q8BZB3 reviewed Tmem266 Q8BZF8 reviewed Pgm5 Q8BZL8 reviewed Lmo3 Q8BZT9 reviewed Lacc1 Q8C0D7 reviewed Ing4 Q8C2W3 unreviewed Oas1e Q8C351 reviewed Layn Q8C3P7 reviewed Mettl3 While different publications agree on the role of N6-methyladenosine (m6A) on RNA stability and its role in embryonic stem cells (ESCs) pluripotency, the precise function of Mettl3 in ESCs self-renewal is unclear. A first paper reported that Mettl3 promotes self-renewal of ESCs by maintaining the groung state of ESCs (PubMed:24394384). However, opposite conclusions were drawn by publications from other groups (PubMed:25456834, PubMed:25569111). The differences may be explained by different experimental conditions (such as cell types or RNAi off-target effects) Q8C3Q5 reviewed Shisa7 SHISA7 has been reported to interact with AMPAR subunit GRIA1 in heterologous conditions and in the brain (PubMed:26623514, PubMed:29199957). However, it was later demonstrated that SHISA7 does not colocalize neither interact with AMPAR, but with GABA(A)R (PubMed:31601770). Therefore additional experiments are needed to understand the discrepancy for SHISA7 function Q8C4Q6 reviewed Aida Q8C5H1 reviewed Ano4 Q8C8C0 unreviewed Mctp1 Q8CBR6 reviewed Tsku Q8CC35 reviewed Synpo Q8CDF7 reviewed Exd1 Q8CEG0 reviewed Panx3 Q8CFA1 reviewed Irak2 Asn-333 is present instead of the conserved Asp which is expected to be an active site residue Q8CGK3 reviewed Lonp1 Q8CGS4 reviewed Chmp3 Q8CGT6 reviewed Piwil4 Q8CGW9 reviewed Dmrtc2 Q8CHM1 reviewed Aqp11 Q8CHQ9 reviewed Nat8f2 Q8CI71 reviewed Vps50 Q8CID3 reviewed Fam20a Q8CIG3 reviewed Kdm1b Q8CIM3 reviewed D2hgdh Q8CIN9 reviewed Rffl Q8CIX8 reviewed Lgsn Q8CIY2 reviewed Duox1 The role of the N-terminal peroxidase-like domain is unclear. The domain has been shown in one study to have peroxidase activity when expressed in E.coli. However, another study showed that the isolated domain does not bind heme and has no intrinsic peroxidase activity Q8CIZ8 reviewed Vwf Q8CJ52 reviewed Prom2 Q8CJB9 reviewed Rnf40 Was originally thought to be cytoplasmic and membrane-associated and to mediate ubiquitination and subsequent degradation of STX1A Q8CJE3 unreviewed Myo7a Q8CNV2 reviewed Q8EBK7 unreviewed nagB Q8EG04 reviewed ycjX Q8GAK7 reviewed aldh Q8GTS1 reviewed BZIP24 Q8GTY0 reviewed A4 Q8GUI6 reviewed JMJ14 Q8GUM2 reviewed HSP70-9 Q8GUN2 reviewed HINT1 Q8GUP3 reviewed PDS5C Q8GVE8 reviewed PPC4 Q8GWG0 reviewed GPAT9 Q8GXE2 reviewed ARD2 Q8GXJ4 reviewed GLR3.4 Q8GXN9 reviewed TGH Q8GXV2 reviewed CXXS2 Lacks the conserved cysteine (here Ser-77), present in the redox-active center, which is one of the conserved features of the thioredoxin family Q8GY23 reviewed UPL1 Q8GY31 reviewed CDC25 Q8GYB8 reviewed OPR2 Q8GYL5 reviewed RPS25D Q8GYY0 reviewed ACS12 Contains a Phe residue instead of a Tyr in position 151, the Tyr residue being essential in substrate recognition by ACS enzymes Q8GZ17 reviewed COBL7 Q8GZ53 reviewed SOT14 Q8H0T4 reviewed UPL2 Q8H102 reviewed BHLH128 Q8H156 reviewed RAN3 Q8H166 reviewed ALEU Q8H1H9 reviewed CuAOgamma1 Q8H1S4 reviewed Q8H1S6 reviewed Q8H6M5 unreviewed BTub6 Q8HZK3 reviewed DUOX1 The role of the N-terminal peroxidase-like domain is unclear. The domain has been shown in one study to have peroxidase activity when expressed in E.coli. However, another study showed that the isolated domain does not bind heme and has no intrinsic peroxidase activity Q8I3W6 unreviewed Q8I7I5 reviewed rol-3 Q8I8U7 reviewed Nipped-A Q8I939 unreviewed Dmel\CG1271 Q8I940 unreviewed Dmel\CG1271 Q8IA41 reviewed pgant11 Although strongly related to polypeptide N-acetylgalactosaminyltransferase proteins, it lacks the conserved Asp-Xaa-His motif in positions 199-201 and the conserved His residue in position 330 which are involved in the binding to the cofactor Mn(2+). This suggests that it may have lost its activity Q8IA44 reviewed pgant12 Although strongly related to polypeptide N-acetylgalactosaminyltransferase proteins, it lacks the conserved His at position 211 which is part of the Asp-Xaa-His motif which binds the cofactor Mn(2+). This suggests that it may have lost its activity Q8IED5 reviewed FD Q8IFM8 reviewed CyRPA CyRPA was thought to be GPI-anchored to the merozoite membrane (PubMed:25583518). However, a subsequent report shows that this was not the case (PubMed:27374406) || CyRPA shares structural homology with sialidases, however the 3 conserved arginine residues involved in substrate binding and the nucleophilic tyrosine residue are not conserved. Does not have sialidase/neuraminidase activity in vitro Q8IGI3 unreviewed Q8IH49 unreviewed Mhcl Q8IH55 unreviewed CG9898 Lacks conserved residue(s) required for the propagation of feature annotation Q8IHE8 unreviewed CG30103;CG30104 Q8IIT5 reviewed pTKL Although it belongs to the kinase superfamily, contains an asparagine residue at the position of the canonical catalytic aspartic acid and does not have kinase activity (PubMed:31148576). However, can bind ATP (PubMed:31148576) Q8IM64 unreviewed Q8IML3 unreviewed Vha100-1 Q8IML4 unreviewed Vha100-1 Q8IML5 unreviewed Vha100-1 Q8IN51 unreviewed Dmel\CG31205 Lacks conserved residue(s) required for the propagation of feature annotation Q8IN62 unreviewed Sordl Q8IN89 unreviewed wrd Q8IN90 unreviewed wrd Q8INA0 unreviewed Dmel\CG31267 Lacks conserved residue(s) required for the propagation of feature annotation Q8INB9 reviewed Akt Q8INC1 unreviewed Mhcl Q8INC3 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q8INF7 reviewed Dnaaf5 Q8ING0 unreviewed CG9645 Lacks conserved residue(s) required for the propagation of feature annotation Q8ING6 unreviewed Argp Q8INR6 reviewed gpp Q8INZ1 reviewed Grl36a Q8IP30 unreviewed SPH208 Lacks conserved residue(s) required for the propagation of feature annotation Q8IPA0 unreviewed Qtzl Q8IPS5 unreviewed CG8220 Q8IPS7 unreviewed Dmel\CG32454 Q8IQ72 reviewed Grl65a Q8IQ79 unreviewed sphinx1 Lacks conserved residue(s) required for the propagation of feature annotation Q8IQD3 unreviewed Dmel\CG32052 Q8IQD9 unreviewed ect Q8IQK2 unreviewed EHR Q8IR04 unreviewed CG9059 Q8IRD3 unreviewed Gtpx Lacks conserved residue(s) required for the propagation of feature annotation Q8IRD4 unreviewed Gtpx Lacks conserved residue(s) required for the propagation of feature annotation Q8IRG6 reviewed dre4 Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity Q8IUH8 reviewed SPPL2C Q8IUL8 reviewed CILP2 Q8IUX7 reviewed AEBP1 Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity Q8IV04 reviewed TBC1D10C Q8IV20 reviewed LACC1 Q8IV48 reviewed ERI1 Q8IV76 reviewed PASD1 Q8IWJ2 reviewed GCC2 Q8IWR1 reviewed TRIM59 Q8IWU4 reviewed SLC30A8 Q8IWV1 reviewed LAX1 Q8IXA5 reviewed SPACA3 Although it belongs to the glycosyl hydrolase 22 family, Thr-122 and Asn-139 are present instead of the conserved Glu and Asp which are active site residues. It is therefore expected that this protein lacks hydrolase activity Q8IXJ6 reviewed SIRT2 Q8IXQ6 reviewed PARP9 Q8IXT2 reviewed DMRTC2 Q8IXY8 reviewed PPIL6 Despite the fact that it belongs to the cyclophilin-type PPIase family, a report has shown that it has probably no peptidyl-prolyl cis-trans isomerase activity Q8IY18 reviewed SMC5 Q8IY95 reviewed TMEM192 Q8IYS1 reviewed PM20D2 Q8IYX1 reviewed TBC1D21 Q8IYX4 reviewed DND1 Q8IZ52 reviewed CHPF Q8IZA3 reviewed H1-8 Q8IZD2 reviewed KMT2E Isoform 3 was originally thought to display histone methyltransferase activity only following O-glycosylation at Thr-440 (PubMed:19377461). However, the corresponding article has been retracted (PubMed:24336203). Does not exhibit histone methyltransferase towards histone H3 in vitro (PubMed:19264965, PubMed:27812132). The isolated catalytic SET domain lacks binding activity towards cofactor S-adenosyl-L-methionine; instead of the highly conserved XGXG, Y and NH motifs, KMT2E displays NKKI (Asn-339-Ile-342), F (Phe-381) and RR (Arg-408-Arg-409) motifs (PubMed:27812132). Also lacks binding activity towards histone H3 due to a poor conservation of the key residues involved in the binding and the presence of large loop which prevents the docking of the H3 'Lys-4' side chain (PubMed:27812132) Q8IZE3 reviewed SCYL3 Q8IZN7 reviewed DEFB107A It is uncertain whether Met-1 or Met-5 is the initiator Q8IZP1 reviewed TBC1D3 Q8IZV5 reviewed RDH10 Q8JG73 unreviewed csnk1a1 Q8JGN5 reviewed birc5.1-a Q8JGT0 unreviewed csnk1a1 Q8JHD9 unreviewed csnk1a1 Q8JHE0 unreviewed csnk1a1 Q8K025 reviewed Frat2 Q8K157 reviewed Galm Q8K1A6 reviewed Cc2d1a Q8K1E6 reviewed Alkbh3 Q8K1K9 reviewed Hinfp Q8K1P7 reviewed Smarca4 Q8K1S5 reviewed Klf11 Q8K1T4 reviewed Ly6g5b Q8K2C6 reviewed Sirt5 The ability to deacetylate Uox in vivo is unclear. The anti-acetylated lysine antibody used in the assay is not fully specific and cross-reacts with some acylated lysines. It is therefore possible that it also recognizes N6-malonyllysine and N6-succinyllysine residues (PubMed:23085393) Q8K2U2 reviewed Alkbh6 Q8K348 reviewed Acvr1c Q8K3B1 reviewed Fbxo45 Q8K3V4 reviewed Padi6 In contrast to other members of the family, does not bind Ca(2+) and is inactive in in vitro assays against standard PADIs substrate (By similarity). At the structural level, the putative active site is in an unsuitable conformation for substrate binding inactive (By similarity) Q8K3Y6 reviewed Zc3hav1 Q8K415 reviewed Slc36a2 Q8K4D3 reviewed Slc36a1 Q8K4F2 reviewed Alox15b Q8K4K2 reviewed Trib3 The role of this protein in Akt activation has been demonstrated in PubMed:12749859 but Iynedjian has not been able to reproduce the result in rat hepatocytes Q8K4K3 reviewed Trib2 Q8K4K4 reviewed Trib1 Q8K4Y5 reviewed Lgi1 Q8K595 reviewed Mcoln2 Q8KBL4 reviewed Although strongly related to RuBisCO family, it lacks the conserved Lys active site in position 327, which is replaced by an Arg residue, suggesting that it may catalyze enolization but not carboxylation Q8L4X6 unreviewed Q8L794 reviewed XK1 Q8L7K9 reviewed NAD-ME2 Q8L7U5 reviewed BSL1 Q8L831 reviewed NUDT3 Q8L840 reviewed RECQL4A Q8L860 reviewed TOL9 Q8L8Y0 reviewed RPS2A Q8L9S1 reviewed RPL18A1 Has been suggested to be a pseudogene, RNA seq evidence shows this is transcribed Q8LA13 reviewed RH11 Q8LA53 reviewed MBD2 Q8LAH7 reviewed OPR1 Q8LBI1 reviewed RPL5A Q8LC83 reviewed RPS24B Q8LCL3 reviewed RPL27B Q8LD03 reviewed RPS7C Q8LD46 reviewed RPL23AA Q8LD49 reviewed ATHX Q8LDI5 reviewed CXXS1 Lacks the conserved cysteine (here Ser-39), present in the redox-active center, which is one of the conserved features of the thioredoxin family Q8LDP4 reviewed CYP19-4 Q8LDQ4 reviewed TAP46 Q8LDU4 reviewed RCCR Q8LDW6 reviewed ENDO3 Q8LEK4 reviewed The active site contains a CGSC motif which differs from the conserved CGPC motif Q8LF21 reviewed DRP1C Q8LFV3 reviewed CDF3 Q8LGB6 reviewed ZED1 Q8LJS9 unreviewed LOC107910594 Q8LPK5 reviewed CESA8 Q8MKK4 reviewed Tret1l Q8MLS8 unreviewed BcDNA:GH11992 Lacks conserved residue(s) required for the propagation of feature annotation Q8MLV1 reviewed LBR Unlike other members of this family, it does not possess sterol C14 reductase activity Q8MLW8 unreviewed Cht12 Lacks conserved residue(s) required for the propagation of feature annotation Q8MLX0 unreviewed Dmel\CG3216 Q8MLZ7 reviewed Idgf3 Q8MM24 reviewed Idgf1 Q8MMH3 reviewed vpr2 Human DCPH1 has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (By similarity). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (By similarity) Q8MQL4 unreviewed Q8MQM9 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8MQR5 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation Q8MR79 unreviewed Pykl5 Q8MRL0 unreviewed Sordl Q8MRZ8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8MS05 unreviewed Ance-4 Lacks conserved residue(s) required for the propagation of feature annotation Q8MS70 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8MSK6 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8MT09 unreviewed Pykl3 Q8MT25 unreviewed Q8MZ84 unreviewed Adgf-E Q8N144 reviewed GJD3 Q8N271 reviewed PROM2 Q8N335 reviewed GPD1L Q8N3F8 reviewed MICALL1 Q8N465 reviewed D2HGDH Q8N5I2 reviewed ARRDC1 Q8N5T2 reviewed TBC1D19 Q8N608 reviewed DPP10 Gly-651 is present instead of the conserved Ser which is expected to be an active site residue suggesting that this protein has no peptidase activity Q8N6Q3 reviewed CD177 Q8N6T7 reviewed SIRT6 Upon DNA damage, was reported to promote DNA end resection via deacetylation of RBBP8. However, this study was later retracted || The binding-mode of MDL-801 selective activator is subject to discussion (PubMed:30374165, PubMed:33649599, PubMed:33649600). According to a group, MDL-801 binds around the acyl channel exit and acts as an allosteric activator (PubMed:30374165, PubMed:33649600). According to another group, the binding mode of MDL-801 remains undefined (PubMed:33649599) Q8N6Y2 reviewed LRRC17 Q8N8N7 reviewed PTGR2 Q8N8Q3 reviewed ENDOV Was initially characterized as an endodeoxyribonuclease involved in DNA repair (PubMed:22664237). While it shows some weak endodeoxyribonuclease activity in vitro, such activity probably does not exist in vivo Q8N8R3 reviewed SLC25A29 Was initially proposed to transport palmitoylcarnitine, based on complementation experiments in yeast mutants lacking CRC1 and CIT2 and release of radiolabeled carnitine from mitochondria incubated with radiolabeled palmitoylcarnithine (By similarity). Later experiments done primarily with human indicate the protein functions instead as transporter of basic amino acids (PubMed:24652292) Q8N9L9 reviewed ACOT4 Q8NA29 reviewed MFSD2A Q8NAA4 reviewed ATG16L2 Q8NB16 reviewed MLKL Q8NB90 reviewed AFG2A Q8NBH6 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8NBN3 reviewed TMEM87A Q8NBQ7 reviewed AQP11 Q8NCC5 reviewed SLC37A3 Q8NDT2 reviewed RBM15B Q8NDX1 reviewed PSD4 Q8NF64 reviewed ZMIZ2 Q8NFK1 reviewed GJC3 Q8NFT6 reviewed DBF4B Q8NHH9 reviewed ATL2 Q8NHL6 reviewed LILRB1 Q8NHP7 reviewed EXD1 Q8NHX9 reviewed TPCN2 Q8NI60 reviewed COQ8A Q8NW23 reviewed Q8P5D0 unreviewed glmS Q8P676 reviewed sucC Q8QGQ3 unreviewed ahr1a Q8QGU2 unreviewed FKBP12.6 Q8QGV5 unreviewed ptgdsb.1 Q8QHA5 reviewed dna2 Q8QZY3 reviewed Dppa3 Q8R0A6 reviewed Vstm2a Q8R0S4 reviewed Cacnb4 Q8R1B5 reviewed Cplx3 Q8R1F1 reviewed Niban2 Q8R1H0 reviewed Hopx Q8R1L8 reviewed Angptl8 Initially reported to specifically promote pancreatic beta cell proliferation without insulin resistance and to promote beta cell mass expansion, thereby improving glucose tolerance (PubMed:23623304). However, this result could not be confirmed by further studies and the original paper was later retracted (PubMed:28038792). The lack of a role in beta cell proliferation was also confirmed in another study (PubMed:25417115) Q8R1M0 reviewed Hmces Was initially reported to specifically bind 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (PubMed:23434322). It was later suggested to act as an endonuclease that specifically cleaves 5hmC-containing DNA (PubMed:29020633). However, recent studies question this activity: no alterations in global 5hmC levels are observed in bone marrow cells from knockout mice (PubMed:31806351) Q8R2S1 reviewed Rps6kl1 Q8R2U6 reviewed Nudt4 Q8R2X8 reviewed Blzf1 Was initially thought to be a potential transcription factor, localized in the nucleus Q8R3F9 reviewed Tut1 Q8R3U1 reviewed Plaat3 Q8R400 reviewed Adig Q8R4A3 reviewed Dact1 Q8R4I6 unreviewed Actn3 Q8R5G2 reviewed Mutyh Q8R5G7 reviewed Arap3 Q8R5I0 reviewed Kcnk15 Q8R5L7 reviewed Fgf14 Q8R5M5 reviewed Acmsd Q8RU31 reviewed MADS21 Q8RUC6 reviewed RUB2 Q8RUH0 unreviewed Q8RUI3 unreviewed MIC-3 Q8RVL2 reviewed DEK1 Q8RWN5 reviewed RZ1C Q8RWS6 reviewed FRO6 Q8RWV0 reviewed TKL-1 Q8RWY6 reviewed CLASP An article reported an auxin transcription module controlling cell division plane rotation through CLASP; however, this paper was later retracted Q8RWZ3 reviewed IBR3 Q8RX71 reviewed BAG4 Q8RXA7 reviewed SCD1 Q8RXD6 reviewed HUB1 Q8RXF8 reviewed MIRO1 Q8RXP6 reviewed WAV2 Q8RXU5 reviewed RPL37AC Q8RY00 reviewed SIA2 Q8RY46 reviewed ABCB26 Q8RY59 reviewed RCD1 Lacks the conserved catalytic triad His-Tyr-Glu of the active site Q8S4P9 reviewed Q8S8T4 reviewed UXS4 Q8S944 reviewed DRP3A Q8S948 reviewed SPS1 Q8S9J8 reviewed Q8SAB7 reviewed SPK1 Q8SPJ0 reviewed RNASE10 Q8SPJ1 reviewed JUP Q8SQ19 reviewed CREB3 Q8SU65 reviewed Although it contains a polysaccharide deacetylase domain, the protein does not display any chitin deacetylase activity Q8SWR8 reviewed Atx2 Q8SXD9 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8SXQ7 reviewed PGRP-LF Q8SXU3 reviewed Gmppa Q8SY93 unreviewed CG9645 Lacks conserved residue(s) required for the propagation of feature annotation Q8SZV2 unreviewed Q8T0R7 reviewed Idgf5 Q8T3K5 unreviewed eIF4EHP Q8T3Q7 unreviewed Khkl1 Q8T434 unreviewed Pykl2 Q8T4B1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8T4I7 unreviewed Q8T6L8 unreviewed dachs Lacks conserved residue(s) required for the propagation of feature annotation Q8T6L9 unreviewed dachs Q8T6M0 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q8T8E5 reviewed MCA4 In contrast to other metacaspases (MCA) of the peptidase C14B family, contains a serine residue at the position of the canonical catalytic cysteine and has been shown to lack protease activity Q8T8Z3 unreviewed G6pdl Q8T980 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q8TAA1 reviewed RNASE11 Predicted to be catalytically inactive based on its sequences lacking the RNase A family-specific catalytic residues Q8TAG5 reviewed VSTM2A Q8TBJ4 reviewed PLPPR1 Has no 2-lysophosphatidate/LPA phosphatase activity. This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved Q8TBP0 reviewed TBC1D16 Q8TC07 reviewed TBC1D15 Q8TCF1 reviewed ZFAND1 Q8TCG5 reviewed CPT1C In contrast to its paralogs, CPT1A and CPT1B, does not have, or at very low levels, carnitine O-palmitoyltransferase activity (EC:2.3.1.21) in vivo, being unable to catalyze the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine. This is in agreement with its expression specific to neurons which is a cell-type that does not use fatty acids as fuel to any major extent and the fact that it locates to endoplasmic reticulum instead of mitochondria Q8TCJ0 reviewed FBXO25 Q8TCT6 reviewed SPPL3 Q8TCT7 reviewed SPPL2B Q8TCT9 reviewed HM13 Q8TD08 reviewed MAPK15 Q8TDC3 reviewed BRSK1 Q8TE67 reviewed EPS8L3 Q8TEA7 reviewed TBCK Q8TEB9 reviewed RHBDD1 One study reported that the protein is not localized in the mitochondrion Q8TEU7 reviewed RAPGEF6 Q8TEY7 reviewed USP33 Q8UVG3 unreviewed Runx2 Q8UW59 reviewed PARK7 Glyoxylase activity previously reported may reflect in fact its deglycase activity || The protein deglycation activity has been ascribed to a TRIS buffer artifact by a publication, which has then been rebutted by clear biochemical experiments showing that PARK7 is a bona fide deglycase. Deglycase activity is even strengthened by a novel article that reports nucleotide deglycation activity Q8UWC8 unreviewed Q8VBV4 reviewed Fbxw7 Q8VCD6 reviewed Reep2 Q8VCP8 reviewed Ak6 AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species Q8VCQ8 unreviewed Cald1 Q8VDD5 reviewed Myh9 Q8VDN2 reviewed Atp1a1 Q8VDQ1 reviewed Ptgr2 Q8VDR7 reviewed Tgds Was initially thought to have dTDP-D-glucose 4,6-dehydratase activity, based on its similarity with bacterial enzymes involved in the synthesis of rhamnose during bacterial cell wall formation. However, it was later shown to have UTP-glucose 4,6-dehydratase activity (PubMed:40836090) Q8VEB4 reviewed Pla2g15 Q8VEI3 reviewed Hyal3 Q8VHK0 reviewed Acot8 Q8VHK5 reviewed Mlc1 Q8VHK7 reviewed Hdgf Q8VHN8 reviewed Nudt16l1 Although strongly related to the nudix NUDT16 protein, lacks the Nudix box and is therefore not related to the rest of the family. Lacks a number of residues which are necessary for hydrolase activity and does not play a role in U8 snoRNA decapping activity Q8VI04 reviewed Asrgl1 Q8VI60 reviewed Sulf1 Q8VI94 reviewed Oasl1 Q8VI95 reviewed Oas1d Q8VI97 unreviewed Oas1h Q8VIK3 reviewed H1.8 Q8VIM9 reviewed Irgq Q8VIP2 reviewed Mlxipl Q8VWF6 reviewed SSL3 Q8VXY9 reviewed UAH Q8VY07 reviewed EPSIN1 Q8VY11 reviewed GYRB3 Was initally described as a type II topoisomerase regulating supercoiling PubMed:15136745, but this function was later refuted PubMed:20360860 Q8VY26 reviewed CCD8 Q8VYA5 reviewed RS2Z33 Q8VYF1 reviewed RPL15B Q8VYF7 reviewed WHY2 Q8VYG2 reviewed GALAK Q8VYK6 reviewed RPS4D Q8VYN9 reviewed PHOS32 Q8VZ19 reviewed RPL30B Q8VZ87 reviewed LHCB1.2 Q8VZP1 reviewed GPP2 Q8VZQ4 reviewed B''GAMMA Q8VZT0 reviewed Q8VZT6 reviewed WCRKC2 The active site contains a CRKC motif which differs from the conserved CGPC motif Q8VZU2 reviewed SYP132 Q8W034 reviewed RNP1 Q8W493 reviewed LFNR2 Q8W4E2 reviewed VHA-B3 Q8W4H7 reviewed A2 Q8W4Q1 unreviewed Q8WSF3 reviewed fdl Q8WTS1 reviewed ABHD5 Q8WUA7 reviewed TBC1D22A Q8WUM4 reviewed PDCD6IP Q8WV92 reviewed MITD1 Q8WWN8 reviewed ARAP3 Q8WWQ2 reviewed HPSE2 Q8WWR8 reviewed NEU4 Q8WWY3 reviewed PRPF31 Q8WXC3 reviewed PYDC1 Q8WZ19 reviewed KCTD13 Baed on animal models in mouse and zebrafish, it was suggested that KCTD13 is the major factor inducing the macrocephaly phenotype associated with the 16p11.2 deletion (PubMed:22596160). However, a subsequent report showed that KCTD13 does not play a role in brain size Q8WZ73 reviewed RFFL Q8WZA9 reviewed IRGQ Q8X1D8 reviewed Q8X1T6 reviewed aah1 Q8Y6F0 unreviewed Q8Y775 reviewed egtUBC Q8Y9V5 reviewed pgdA Q8ZR27 unreviewed ybdH Q902F8 reviewed ERVK-8 Q902F9 reviewed HERVK_113 Q90410 unreviewed gata1a Q90477 reviewed myod1 Q90635 reviewed DPYSL2 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q90656 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q90751 reviewed BMP2 Q90754 unreviewed BRK-1 Q90998 unreviewed Q90999 reviewed TGFBR2 Q90W83 unreviewed akr Q90XW5 reviewed irx5 Q90XW6 reviewed irx4-a Q90Z12 reviewed hes4-a Multiple papers report expression in the developing neural crest and a role in neural crest formation. However, PubMed:17724611 reports differences between the duplicated hes4 gene products and shows that hes4-B/hairy2b but not hes4-A/hairy2a has a role in neural crest formation, and that hes4-B/hairy2b but not hes4-A/hairy2a is expressed in the presumptive neural crest Q90Z37 reviewed cdh1 Q90Z43 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q90Z44 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q90Z45 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q90ZG0 unreviewed FKBP12 Q90ZK6 reviewed ACVR1 Q90ZL2 reviewed lancl1 Q90ZN6 unreviewed mst1 Lacks conserved residue(s) required for the propagation of feature annotation Q91030 unreviewed CWT1 Q91372 reviewed ddx4 Q91V33 reviewed Khdrbs1 Q91VC0 reviewed Dctpp1 Q91VL8 reviewed Terf2ip Q91VN0 reviewed Lrp5 Q91VZ6 reviewed Smap1 Q91WA9 reviewed Abcg4 Q91WB2 reviewed Plpp7 Q91WC1 reviewed Pot1 Q91WE1 reviewed Snx15 Q91WM1 reviewed Strbp Q91WS2 reviewed Nlrp6 The role of the NLRP6 inflammasome in the regulation of the gut microbiota composition is unclear (PubMed:21565393, PubMed:22763455, PubMed:26638072, PubMed:28801232, PubMed:29281815, PubMed:29281837). Some studies suggest that NLRP6 shapes the commensal gut microbiota composition (PubMed:21565393, PubMed:22763455, PubMed:26638072). However, other groups do not observe any difference in microbiota composition between wild-type and knockout mice (PubMed:28801232, PubMed:29281815, PubMed:29281837). Differences observed were attributed to mother and cage covariates rather than Nlrp6 deficiency (PubMed:28801232, PubMed:29281815, PubMed:29281837) Q91XQ2 reviewed Epm2a Q91XT9 reviewed Asah2 Q91XW8 reviewed Fkbp6 Although it contains a PPIase FKBP-type domain, does not show peptidyl-prolyl cis-trans isomerase activity Q91YD4 reviewed Trpm2 Q91YH6 reviewed Atp6v1b1 Q91YN9 reviewed Bag2 Q91YP6 reviewed Elmod3 Q91YT7 reviewed Ythdf2 Previous studies suggested the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (By similarity). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32943573) Q91ZJ9 reviewed Hyal1 Q91ZN1 reviewed Coro1a Q91ZW6 reviewed Tmlhe Q921A2 reviewed Slc2a13 Q922Y2 reviewed Trim59 Q92339 reviewed ght3 Q92340 reviewed shu1 Q92353 reviewed ubp6 Q92355 reviewed sen1 Q92357 reviewed cfr1 Q923D5 reviewed Wbp11 Q923I8 reviewed Cry2 Q923K9 reviewed A1cf Q923Q2 reviewed Stard13 Q923S6 reviewed Neurl1 Q923S8 reviewed Pank4 Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity Q92484 reviewed SMPDL3A Q924A5 reviewed Slc36a1 Q924N4 reviewed Slc12a6 Q924N5 reviewed Acsbg1 Q924S2 reviewed Oas1c Q924S5 reviewed Lonp1 Q924V1 reviewed Nox4 Q924W9 reviewed Lmo1 Q92519 reviewed TRIB2 Q92581 reviewed SLC9A6 Was originally (PubMed:9507001) identified as a mitochondrial inner membrane protein, but was later shown to be localized in early and recycling endosomes and not mitochondria (PubMed:11641397, PubMed:11940519) Q925B4 reviewed Syt8 Q925G1 reviewed Hdgfl2 Q925U4 reviewed Edem1 Q92609 reviewed TBC1D5 Q92611 reviewed EDEM1 Q92614 reviewed MYO18A The TIAF1 protein is coded in the 3'-UTR region of MYO18A Q92622 reviewed RUBCN Q92738 reviewed USP6NL Q92785 reviewed DPF2 Q92800 reviewed EZH1 Q92804 reviewed TAF15 Q92833 reviewed JARID2 Q92878 reviewed RAD50 Q92889 reviewed ERCC4 Q92930 reviewed RAB8B Q93063 reviewed EXT2 Q93088 reviewed BHMT Q93091 reviewed RNASE6 Q93413 unreviewed drh-3 Q93725 reviewed ned-8 Q93V47 reviewed GG2 Q93VB8 reviewed RPS2B Q93VC9 reviewed CATHB2 Q93VG5 reviewed RPS8A Q93VH9 reviewed RPS4A Q93VI3 reviewed RPL17A Q93VP3 reviewed ELF5A-2 Q93VT9 reviewed RPL10A Q93W22 reviewed RPL10C Q93WF6 reviewed SAG21 Q93Y07 reviewed SFR2 Q93Y31 reviewed ARL8B Q93YV0 reviewed GES Q93Z81 reviewed CAX3 Q93ZC9 reviewed GLCAK1 Q93ZG7 reviewed RH38 Q93ZL5 reviewed CDF2 Q93ZM9 reviewed TIFY9 Q93ZN9 reviewed DAP Q93ZW0 reviewed G6PD4 Q93ZY2 reviewed ROPGEF1 Q940B0 reviewed RPL18C Q940G6 reviewed GID1C Q940H6 reviewed SRK2E Q943E9 reviewed HSP17.9B Q944K2 reviewed OST48 Q946J8 reviewed LHP1 Q94901 reviewed lark Q949H3 reviewed CHI-L1 Lacks the conserved Glu active site in position 136, which is replaced by an Ala residue, explaining why it is inactive Q949P3 reviewed Q949T8 reviewed ASHR3 Q94A06 reviewed MKK1 Q94A08 reviewed RFS2 Q94A28 reviewed ACO2 Q94AH8 reviewed TPS6 Q94AM1 reviewed OOP Q94AU7 reviewed GAMMACA3 Q94B38 reviewed GPT2 Q94B60 reviewed CLPP4 Q94BQ2 reviewed RPT6B Q94C77 reviewed Q94CE5 reviewed POP2 Q94EH2 reviewed TIM22-2 Q94JQ3 reviewed SHM3 Q95083 reviewed Prosalpha5 Q95152 reviewed PDPN Q95203 reviewed CA11 Q95229 reviewed PDGFB Q95JX4 reviewed GALNTL5 In contrast to other members of the family, lacks the C-terminal ricin B-type lectin domain, which contributes to the glycopeptide specificity. The precise function of the enzyme is therefore unsure Q95L74 reviewed CYBB Q95LI9 reviewed PARK7 Glyoxalase activity has been reported. It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed Q95NV8 unreviewed AstC Q95R35 reviewed S-Lap4 Although it belongs to the peptidase M17 family, lacks the active site Lys and Arg residues and zinc binding sites, suggesting it has no aminopeptidase activity Q95RK3 unreviewed Q95RQ4 reviewed Snp Q95RR5 unreviewed Pi3K68D Q95RR8 reviewed PAN3 Q95RS6 unreviewed Sph242 Lacks conserved residue(s) required for the propagation of feature annotation Q95S79 unreviewed Swim Lacks conserved residue(s) required for the propagation of feature annotation Q95SI6 unreviewed CG9898 Q95SL6 unreviewed intr Lacks conserved residue(s) required for the propagation of feature annotation Q95T03 unreviewed Pcif1 Q95T19 reviewed Slimp Q95T64 reviewed PGRP-LA Q95U59 unreviewed Ance-5 Lacks conserved residue(s) required for the propagation of feature annotation Q95VU9 unreviewed dachs Q95YD4 reviewed kin-32 Q95YI5 reviewed frc Q960B9 unreviewed Pcif1 Q960G3 unreviewed mop Q960K4 unreviewed dachs Lacks conserved residue(s) required for the propagation of feature annotation Q960V2 unreviewed Prp8 Lacks conserved residue(s) required for the propagation of feature annotation Q961R7 unreviewed CG4224 Q961W5 reviewed S-Lap3 Although it belongs to the peptidase M17 family, lacks the active site Lys and Arg residues and zinc binding sites, suggesting it has no aminopeptidase activity Q96250 reviewed ATPC Q96251 reviewed Q96255 reviewed PSAT1 Q96262 reviewed PCAP1 Q96291 reviewed BAS1 Q96292 reviewed ACT2 Q96300 reviewed GRF7 Q96327 reviewed EBP1 Q96329 reviewed ACX4 Q96524 reviewed CRY2 Was originally thought to be a DNA photolyase Q96528 reviewed CAT1 Q96529 reviewed PURA Q96565 reviewed Q965W9 reviewed mtm-9 Although it belongs to the non-receptor class myotubularin subfamily, lacks the conserved active site cysteine residue at position 346 in the dsPTPase catalytic loop, suggesting that it has no phosphatase activity Q969S8 reviewed HDAC10 Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N(8)-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates (PubMed:28516954). However, histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901, PubMed:28516954). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039) Q969S9 reviewed GFM2 Q96A70 reviewed AZIN2 Was initially reported to have ornithine decarboxylase (PubMed:11587527) or arginine decarboxylase (PubMed:14738999) activities, but it was later found that the mouse ortholog does not possess either of them Q96AE4 reviewed FUBP1 Q96AY2 reviewed EME1 Q96B26 reviewed EXOSC8 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q96BZ9 reviewed TBC1D20 Q96C03 reviewed MIEF2 Q96C23 reviewed GALM Q96C45 reviewed ULK4 Q96CC6 reviewed RHBDF1 Lacks serine protease activity as it lacks the catalytic Ser residue at position 720 Q96D53 reviewed COQ8B Q96DN0 reviewed ERP27 Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family Q96DN6 reviewed MBD6 Q96EB6 reviewed SIRT1 Q96EG1 reviewed ARSG Q96EM0 reviewed L3HYPDH Q96EP9 reviewed SLC10A4 Q96EU7 reviewed C1GALT1C1 Was originally (PubMed:12361956) assigned to be a glycosyltransferase. However, it was later shown (Ref.2 and PubMed:12464682) that it has no transferase activity and rather acts as a chaperone Q96F10 reviewed SAT2 Diamine acetyltransferase activity is unclear (PubMed:12803540, PubMed:15283699). According to a report, mediates acetylation of polyamines, such as norspermidine, spermidine or spermine (PubMed:12803540). However, another publication showed that such activity is weak compared to thialysine acetyltransferase activity, suggesting that polyamines are not substrates in vivo (PubMed:15283699) Q96FC9 reviewed DDX11 Q96FG2 reviewed ELMOD3 Q96FZ2 reviewed HMCES Was initially reported to specifically bind 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). It was later suggested to act as an endonuclease that specifically cleaves 5hmC-containing DNA (By similarity). However, the endonuclease activity on 5hmC-containing DNA could not be confirmed by another report (PubMed:30554877) Q96FZ7 reviewed CHMP6 Q96GD4 reviewed AURKB Q96H20 reviewed SNF8 Q96HN2 reviewed AHCYL2 Q96HU1 reviewed SGSM3 Q96HU8 reviewed DIRAS2 Q96I99 reviewed SUCLG2 Q96IJ6 reviewed GMPPA Q96JB5 reviewed CDK5RAP3 Q96JG6 reviewed VPS50 Q96KN2 reviewed CNDP1 The activity towards anserine which was originally shown with purified serum carnosine could not be confirmed Q96KX0 reviewed LYZL4 Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity Q96L12 reviewed CALR3 Q96L34 reviewed MARK4 Q96MF7 reviewed NSMCE2 Q96MG8 reviewed PCMTD1 Although the active site residue Ser is conserved, appears to lack catalytic activity in vitro Q96MK3 reviewed FAM20A Although strongly related to other members of the family, lacks the kinase activity. A conserved Asp/Glu residue present in other members of the family, which coordinates the Mn(2+) ion and the ion-pair Lys and is indispensable for kinase activity, is replaced by a Gln in position 258 Q96N87 reviewed SLC6A18 The mouse ortholog protein is an active neutral amino acid transporter Q96NN9 reviewed AIFM3 Q96NT5 reviewed SLC46A1 Q96PN6 reviewed ADCY10 Q96QB1 reviewed DLC1 Q96QE2 reviewed SLC2A13 Q96QE5 reviewed TEFM Q96QU6 reviewed ACCS Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity Q96QZ0 reviewed PANX3 Q96RD6 reviewed PANX2 Q96RD7 reviewed PANX1 Q96RU7 reviewed TRIB3 The role of this protein in Akt activation has been demonstrated by Du et al (PubMed:12791994) for the mouse ortholog but Iynedjian (PubMed:15469416) has not been able to reproduce the result in rat hepatocytes Q96RU8 reviewed TRIB1 Q96S38 reviewed RPS6KC1 Although this protein belongs to the protein kinase superfamily, it does not display kinase activity Q96S97 reviewed MYADM Q96T23 reviewed RSF1 Q96T37 reviewed RBM15 Q96TA1 reviewed NIBAN2 Q96WV2 reviewed opy1 Q97VW8 reviewed thrS-cat Q980D1 reviewed thrS-ed Q99376 reviewed Tfrc Q99463 reviewed NPY6RP Could be the product of a pseudogene. According to PubMed:8910290, PubMed:8910373, PubMed:9013614, the human NPY6R gene is an expressed pseudogene containing a premature stop codon and encoding a non-functional truncated protein missing the last transmembrane domain. A single base pair deletion relative to the mouse ortholog, results in a truncated protein lacking the seventh transmembrane domain Q99497 reviewed PARK7 Glyoxalase activity has been reported (PubMed:22523093, PubMed:31653696). It may however reflect its deglycase activity (PubMed:25416785) || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication (PubMed:27903648) and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one (PubMed:31653696). However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed (PubMed:25416785, PubMed:28013050, PubMed:28596309) Q99527 reviewed GPER1 Data is conflicting regarding whether it fulfills the criteria of a membrane-bound estrogen receptor (PubMed:15705806, PubMed:17379646). Other reports suggest that it is not (PubMed:16645038, PubMed:18566127) || Data is conflicting regarding whether it is localized either at the cell membrane (PM) (PubMed:15539556, PubMed:21149639, PubMed:21354433, PubMed:21427217, PubMed:21540189, PubMed:23674134). Other reports suggest that it localizes at the endoplasmic reticulum (ER) (PubMed:15705806, PubMed:18566127) Q99571 reviewed P2RX4 Q99578 reviewed RIT2 Q99623 reviewed PHB2 Q99741 reviewed CDC6 Q99816 reviewed TSG101 Q99944 reviewed EGFL8 Q99J45 reviewed Nrbp1 Q99J82 reviewed Ilk Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein Q99JB2 reviewed Stoml2 Q99JB8 reviewed Pacsin3 Q99JG2 reviewed Gpr37l1 Has been reported to act as a receptor for prosaposin (PSAP). However, it has also been shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor Q99JY1 reviewed Tirap Q99K10 reviewed Nlgn1 Q99LD8 reviewed Ddah2 Was originally thought to be a dimethylarginine dimethylaminohydrolase (with EC:3.5.3.18) able to hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA). However, a recent multicentre study have shown that DDAH2 does not have dimethylarginine dimethylaminohydrolase activity by using different approaches Q99LM2 reviewed Cdk5rap3 Q99LX0 reviewed Park7 Glyoxalase activity has been reported (PubMed:22523093). It may however reflect its deglycase activity || The protein deglycation activity is controversial. It has been ascribed to a TRIS buffer artifact by a publication and as a result of the removal of methylglyoxal by glyoxalase activity that leads to a subsequent decomposition of hemithioacetals and hemianimals due to the shift in equilibrium position by another one. However, biochemical experiments showing that PARK7 is a bona fide deglycase have been performed Q99MA1 unreviewed Cited2 Q99MB5 reviewed Lmo3 Q99ME6 reviewed Atp1b4 Q99MF5 reviewed Il11 Q99MH5 reviewed Nme5 Q99MY2 reviewed Nudt4 Q99N13 reviewed Hdac9 Q99P30 reviewed Nudt7 Q99P55 reviewed Sgpp1 Q99PL7 reviewed Scd3 Q99PL8 reviewed Slc19a3 Q99PU5 reviewed Acsbg1 Q9AQU5 reviewed PIP1-3 Q9AR14 reviewed PIP1-5 Q9ASR1 reviewed LOS1 Q9ATN0 reviewed PIP1-6 Q9AYE3 unreviewed Q9BDK6 reviewed ATP1B4 Q9BH09 reviewed HGF Has lost two of the three essential catalytic residues and so probably has no enzymatic activity Q9BKN7 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation Q9BL73 unreviewed ppk-2 Q9BPU6 reviewed DPYSL5 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q9BQ15 reviewed NABP2 Q9BQA5 reviewed HINFP Q9BRJ7 reviewed NUDT16L1 Although strongly related to the nudix NUDT16 protein, lacks the Nudix box and is therefore not related to the rest of the family (PubMed:18820299, PubMed:21070968). Gene organization and evolutionary distribution suggest that syndesmos NUDT16L1 probably originated as a gene duplication event of the more ancient U8 snoRNA-decapping enzyme NUDT16 (PubMed:18820299). Although similar to U8 snoRNA-decapping enzyme NUDT16, lacks a number of residues which are necessary for hydrolase activity and does not play a role in U8 snoRNA decapping activity (PubMed:21070968) Q9BSA4 reviewed TTYH2 According to PubMed:34385445, lacks Ca(2+)-activated chloride channel and swelling-dependent volume-regulated anion channel activities Q9BSI4 reviewed TINF2 Q9BT88 reviewed SYT11 Q9BUL8 reviewed PDCD10 Q9BUQ8 reviewed DDX23 Q9BUT1 reviewed BDH2 Postulated to act as a 3-hydroxybutyrate dehydrogenase, however its contribution to ketone body formation appears to be physiologically irrelevant since it has very low affinity for the substrate Q9BV40 reviewed VAMP8 Q9BV94 reviewed EDEM2 Has similarity to alpha 1,2-mannosidases, but the catalytic activity of this protein is controversial (PubMed:15537790, PubMed:25092655). One study shows that it is important for a specific oligosaccharide trimming step from Man9GlcNAc2 to Man8GlcNAc2, suggesting activity as a mannosidase (PubMed:25092655). However, another study reports that this protein has no mannosidase activity (PubMed:15537790) Q9BX10 reviewed GTPBP2 Q9BXB1 reviewed LGR4 Q9BXI6 reviewed TBC1D10A Q9BXJ8 reviewed TMEM120A Whether TMEM120S functions as a mechanosensitive ion channel is controversial (By similarity). Several studies show that TMEM120A does not exhibit mechanosensitive channel activity and display no typical ion channel structural characteristics (PubMed:34374645, PubMed:34409941, PubMed:34465718). One publication, however, suggests the presence of a potential ion permeation pathway based on molecular dynamics simulation (PubMed:35235791). Its structural homology to ELOVL7, leads to suggest than TMEM120A may function as an enzyme involved in fatty acid metabolism, although its enzymatic activity and its potential substrates remain unknown (PubMed:34374645, PubMed:34409941, PubMed:34465718). Whether TMEM120A is an enzyme rather than an ion channel is still under debate Q9BXT5 reviewed TEX15 Q9BY49 reviewed PECR Q9BY67 reviewed CADM1 Q9BYJ1 reviewed ALOXE3 Q9BYJ9 reviewed YTHDF1 Was initially reported to act as a regulator of mRNA translation efficiency by promoting ribosome loading to m6A-containing mRNAs and by interacting with translation initiation factors eIF3 (EIF3A or EIF3B), thereby facilitating translation initiation (PubMed:26046440, PubMed:26593424). These studies suggested that the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:26046440, PubMed:26593424). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32492408). The effect on translation efficiency observed earlier is probably indirect (PubMed:32492408) Q9BYT9 reviewed ANO3 Q9BYX2 reviewed TBC1D2 Q9BYZ8 reviewed REG4 Q9BZC7 reviewed ABCA2 Q9BZG1 reviewed RAB34 Q9C030 reviewed TRIM6 Q9C0H2 reviewed TTYH3 According to PubMed:34385445, lacks Ca(2+)-activated chloride channel and swelling-dependent volume-regulated anion channel activities Q9C0H9 reviewed SRCIN1 Q9C0K7 reviewed STRADB Ser-184 is present instead of the conserved Asp which is expected to be an active site residue Q9C105 reviewed cts2 Lacks the conserved Glu residue in position 166 essential for chitinase activity. Its enzyme activity is therefore unsure Q9C589 reviewed ATR7 Q9C597 unreviewed RAD7C Q9C5A9 reviewed Q9C5M0 reviewed DTC Q9C5P4 reviewed SUVH3 Q9C5U0 reviewed AHK4 Q9C5U1 reviewed AHK3 Q9C5U2 reviewed AHK2 Q9C690 reviewed BHLH122 Q9C6B3 reviewed GAMMACA2 Q9C6I4 reviewed GA2OX7 Q9C793 reviewed AGO7 Q9C7F5 reviewed NTF2B Q9C7G0 reviewed MAP65-8 Q9C7V5 reviewed PCMP-E65 Q9C7W7 reviewed UGE4 Q9C865 reviewed SH3P1 Q9C8E6 reviewed PMI1 Q9C8L4 reviewed GLY3 Was initially thought to be a glyoxalase II isozyme (PubMed:9349270), but has been shown to lack glyoxalase activity (PubMed:22786886) Q9C8M5 reviewed WAG1 Q9C8Z4 reviewed Q9C912 reviewed RPL35AC Q9C958 reviewed SRK2B Q9C9C6 reviewed RPL6B Q9C9G4 reviewed ENDO2 Q9C9H5 reviewed CEL3 Q9C9H8 reviewed SCYL2B Although it belongs to the kinase superfamily, lacks the residues involved in ATP binding, suggesting that it has no protein kinase activity Q9C9K2 reviewed CP12-3 Q9C9L0 reviewed CUL3B Q9C9Q4 reviewed JAC1 Q9C9T2 reviewed SARD1 Q9C9X7 reviewed IDD14 Q9CA19 reviewed RPS13 Q9CA45 reviewed SOFL2 Q9CA51 reviewed MIF1 Q9CA60 reviewed CYP98A9 Q9CA86 reviewed PEX2 Q9CAI7 reviewed TIF4A-3 Q9CAQ2 reviewed Q9CAT3 unreviewed Q9CAV0 reviewed RPS3AA Q9CAX6 reviewed RPS14B Q9CAX7 unreviewed Q9CAZ7 reviewed SSL5 Q9CPU9 reviewed Slc31a2 Q9CQ49 reviewed Ncbp2 Q9CQG2 reviewed Mettl16 According to a report, N6-methylation of MAT2A affects MAT2A mRNA stability instead of preventing splicing (PubMed:29262316). However, it was later shown that N6-methylation of MAT2A transcripts prevents recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production (By similarity) Q9CR51 reviewed Atp6v1g1 Q9CUS9 reviewed Sppl3 Q9CWR7 reviewed Steap1 Q9CWR8 reviewed Dnmt3l Q9CXA2 reviewed L3hypdh Q9CXD9 reviewed Lrrc17 Q9CXM0 reviewed Chodl Q9D1G2 reviewed Pmvk Was originally thought to be located in the peroxisome. However, was later shown to be cytosolic Q9D1N2 reviewed Gpihbp1 Q9D1P4 reviewed Chordc1 Q9D2L5 reviewed Cpxm2 Although related to peptidase M14 family, lacks the active site residues and zinc-binding sites, suggesting that it has no carboxypeptidase activity Q9D2Y4 reviewed Mlkl Q9D385 reviewed Arl2bp Q9D410 unreviewed Q9D4M9 reviewed Galntl5 In contrast to other members of the family, lacks the C-terminal ricin B-type lectin domain that contributes to the glycopeptide specificity, and lacks the conserved His residue in position 341. No glycosyltransferase activity has been detected in an in vitro assay (PubMed:24398516) Q9D5A9 reviewed Rnase10 Q9D666 reviewed Sun1 Q9D6H2 reviewed Ift25 Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:22595669) Q9D6Z0 reviewed Alkbh7 Q9D8F1 reviewed Alkbh4 Q9D8U3 reviewed Erp27 Does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family Q9D925 reviewed Lyzl4 Although it belongs to the glycosyl hydrolase 22 family, Gly-72 is present instead of the conserved Asp which is an active site residue. It is therefore expected that this protein lacks hydrolase activity Q9D9H3 reviewed Mbd3l1 Q9D9R7 reviewed Dmrtc1 Although related to other DMRT proteins, it does not contain a canonical DM DNA-binding domain Q9DA75 reviewed Mfsd2a Q9DA79 reviewed Dpep3 According to PubMed:12738806, exhibits dipeptidase activity hydrolyzing cystinyl-bis-glycine but according to PubMed:32325220, lacks this activity which may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide Q9DAA4 reviewed Prss37 Although related to peptidase S1 family, lacks the conserved active Ser residue in position 192 which is replaced by an Ala, suggesting that it has no protease activity. Also lacks metal binding sites Glu in position 67 which is replaced by Asn, and Asn in position 69 which is replaced by Lys Q9DAE7 reviewed Q9DAM5 reviewed Slc25a19 Previously identified as the mitochondrial deoxyribonucleotide carrier. However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier Q9DAM9 reviewed Fank1 Q9DB60 reviewed Prxl2b Q9DBD0 reviewed Inhca Q9DBL9 reviewed Abhd5 Q9DC51 reviewed Gnai3 Q9DDW4 unreviewed Q9DE46 reviewed pola1 Q9DF58 reviewed ILK Was originally thought to act as a serine/threonine-protein kinase. Now thought to be a pseudokinase which does not have kinase activity and which functions solely as a scaffold protein Q9DGL5 unreviewed atp1a2a Q9DGW5 reviewed MDV005 Q9EPK2 reviewed Rp2 Q9EPK8 reviewed Trpv4 Q9EPX0 reviewed Hspb8 Q9EQ32 reviewed Pik3ap1 Q9EQF4 reviewed Izumo1r In contrast to FOLR1 and FOLR2, unable to bind folate Q9EQF6 reviewed Dpysl5 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q9EQJ0 reviewed Tpcn1 Q9EQQ4 reviewed Gpr45 Although it is part of the G protein-coupled receptor 1 family, does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia Q9EQT5 reviewed Tinagl1 Q9EQX0 reviewed Ghrl Q9ERD9 reviewed Ido1 Q9ERH7 reviewed Hipk3 Q9ERI6 reviewed Rdh14 Q9ERL1 unreviewed Cybb Q9ERR1 reviewed Ndel1 Q9ERW3 reviewed Fgf13 Q9ERZ8 reviewed Trpv4 Q9ES54 reviewed Nploc4 Q9ESQ9 reviewed Npvf Q9ESR9 reviewed Abca2 Q9ESS2 reviewed Fgf22 Q9ESU6 reviewed Brd4 Q9ET37 reviewed Slc5a4a Q9ET43 reviewed Cldn12 Q9FEF8 reviewed FIB1 Q9FER4 unreviewed paa Q9FF52 reviewed RPL12C Q9FF55 reviewed PDIL1-4 Q9FF80 reviewed SUVH1 Q9FF99 reviewed AAP7 Q9FFD2 reviewed RGP5 Q9FFW2 reviewed Q9FFX6 reviewed EXO70C2 Q9FG36 reviewed WCRKC1 Q9FGM0 reviewed FTSH11 Q9FGT8 reviewed TIL Q9FH80 reviewed BAM8 Q9FHL8 unreviewed Q9FHN1 unreviewed Q9FI15 unreviewed MFC16.18 Q9FI23 reviewed PDF1.2A Q9FI56 reviewed CLPC1 Q9FI76 reviewed DHNAT2 Q9FIQ0 reviewed AGD9 Q9FIW1 reviewed STMP9 Q9FJA6 reviewed RPS3C Q9FJD4 reviewed KPNB1 Q9FJF1 unreviewed ATRABE1B Q9FJF4 reviewed MBD7 Q9FJG3 reviewed MCTP16 Q9FJH0 reviewed RABA1F Q9FJR0 reviewed UPF1 Q9FJX3 reviewed VDAC2 Q9FK35 reviewed ADK2 Q9FK51 reviewed Q9FKA0 reviewed NAC92 Q9FKL8 reviewed XTH13 Q9FKL9 reviewed XTH12 Q9FKS0 reviewed UKL1 Was prevsiouly characterized as an enzyme that possesses uracil phosphoribosyltransferase (UPRT) activity (PubMed:17143579). Further publications show a lack of such activity (PubMed:19563437, PubMed:21828290) Q9FLF0 reviewed RPS9C Q9FLQ4 reviewed Q9FLV0 reviewed DMR6 Q9FLW9 reviewed PKP2 Q9FLY0 reviewed SARD4 Q9FM19 reviewed HIR1 Q9FM68 reviewed BAM4 In contrast to other members of the family, lacks the conserved Glu active site in position 473, which is replaced by an Arg residue, explaining why it is inactive Q9FMD7 reviewed Q9FMF9 unreviewed MSJ1.11 Q9FMH6 reviewed WPP1 Q9FMM0 reviewed UBC18 Q9FMU6 reviewed MPT3 Q9FNF8 reviewed PI4KG3 Q9FNK4 reviewed DELTA-OAT Q9FPJ4 reviewed RABD2B Q9FPR3 reviewed EDR1 Q9FR53 reviewed TOR Q9FSE5 unreviewed rci-1 Q9FT52 reviewed Q9FT77 reviewed RLM3 Q9FVI6 reviewed HDG6 Q9FVP6 unreviewed EPSPS Q9FVQ1 reviewed NUCL1 Q9FVT2 reviewed Q9FWR5 reviewed GAMMACA1 Q9FWT2 reviewed UBC16 Q9FX54 reviewed GAPC2 Q9FX55 reviewed STO9 Q9FX56 reviewed SOT8 Q9FXD4 unreviewed Q9FXQ7 unreviewed ZmRR3 Q9FY54 reviewed SPS2 Q9FY64 reviewed RPS15D Q9FY65 reviewed RPS15C Q9FY95 reviewed EXO70C1 Q9FYH1 reviewed HAC2 Q9FYL6 reviewed KCR2 Q9FYQ8 reviewed TMN11 Q9FZ21 reviewed GA2OX6 Q9FZH0 reviewed RPL35AB Q9FZK4 reviewed NTF2A Q9GKK4 reviewed GALK1 Q9GN97 reviewed PGRP-LD Q9GNK5 reviewed PGRP-LC Q9GPI2 unreviewed AttD Q9GSR1 reviewed PolZ1 Q9GZ15 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation Q9GZM7 reviewed TINAGL1 Q9GZS9 reviewed CHST5 Q9H082 reviewed RAB33B Q9H0F7 reviewed ARL6 Q9H0U4 reviewed RAB1B Q9H1J1 reviewed UPF3A Q9H227 reviewed GBA3 The sequence shown in this entry differs from the translation of the reference genome assembly (GRCh38/hg38) due to a nonsense variant creating stop codon at position 456 in the reference genome Q9H267 reviewed VPS33B According to PubMed:18474358, it is autophosphorylated. However, it is not related with protein kinases, suggesting it is phosphorylated by another protein Q9H299 reviewed SH3BGRL3 Q9H2G9 reviewed BLZF1 Was originally identified as a potential transcription factor, because of the presence of a potential basic motif and leucine-zipper domain, and because isoform 1 is detected in the nucleus upon heterologous expression. However, homology at several typical position for basic or hydrophobic residues is missing. Besides, another publication showed it is important for normal Golgi apparatus structure and function Q9H2M3 reviewed BHMT2 Q9H313 reviewed TTYH1 According to PubMed:34385445, lacks swelling-dependent volume-regulated anion channel activity Q9H329 reviewed EPB41L4B Q9H427 reviewed KCNK15 Q9H4B8 reviewed DPEP3 Q9H4Z3 reviewed PCIF1 The role of N(6),2'-O-dimethyladenosine cap (m6A(m)) on transcripts is unclear and subject to discussion (PubMed:30467178, PubMed:31279658, PubMed:31279659). According to a report, m6A(m) promotes translation of capped mRNAs (PubMed:30467178). In contrast, another study did not observe a clear effect on mRNA translation, but reported an increased stability of a subset of m6A(m) transcripts (PubMed:31279658). According to a third report, m6A(m) inhibits mRNA translation without affecting mRNA stability (PubMed:31279659) Q9H6E5 reviewed TUT1 Q9H773 reviewed DCTPP1 Q9H792 reviewed PEAK1 Has been the subject of controversy surrounding its catalytic capabilities. Early characterization of PEAK1 gave a weak in vitro tyrosine kinase activity (PubMed:20534451). The crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft that in this conformation may deleteriously affect nucleotide binding (PubMed:29212708). Furthermore PEAK1 is devoid of nucleotide binding activity, as detected by a thermal-shift assay (PubMed:24107129). So it seems probable that PEAK1 is an inactive kinase Q9H7H0 reviewed METTL17 Q9H7P6 reviewed MVB12B Q9H825 reviewed METTL8 The existence of N(3)-methylcytidine on mRNA is unclear (PubMed:33313824, PubMed:34774131). A report was unable to detect N(3)-methylcytidine formation in mammalian mRNAs using a nucleotide-resolution sequencing approach (PubMed:33313824). According to another publication, METTL8 has no activity on mRNAs and specifically methylates mitochondrial tRNAs (PubMed:34774131) || A publication reported some nucleolar localization (PubMed:32199293). However, the protein used in this publication used a N-terminal tag, which possibly interferes with the mitochondrial targeting (PubMed:34774131) Q9H8T0 reviewed AKTIP Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity Q9H993 reviewed DCPH1 Has been reportedly associated with a protein carboxyl methyltransferase activity, but whether this protein indeed has such an activity remains to be determined (PubMed:25732820). It has been later shown to belong to a family of metal-dependent phosphatases implicated in metabolite damage-control (PubMed:27322068) and the O-methyltransferase activity has not been seen by other authors in (PubMed:32682077) Q9H9C1 reviewed VIPAS39 Q9H9G7 reviewed AGO3 Q9H9J2 reviewed MRPL44 Lacks RNase activity due to the absence of RNase-specific catalytic domain Q9H9P2 reviewed CHODL Q9HA65 reviewed TBC1D17 Q9HAW8 reviewed UGT1A10 Q9HAW9 reviewed UGT1A8 Q9HAZ2 reviewed PRDM16 Q9HBH5 reviewed RDH14 Q9HBX8 reviewed LGR6 Q9HC21 reviewed SLC25A19 Previously identified as the mitochondrial deoxyribonucleotide carrier (PubMed:11226231). However other experiments later demonstrated that SLC25A19 is a thiamine diphosphate transporter and not a mitochondrial deoxyribonucleotide carrier (PubMed:15539640, PubMed:18280798) Q9HC97 reviewed GPR35 Was initially thought to act as a receptor for the C-X-C chemokine receptor CXCL17 (PubMed:25411203). However, it was later shown to not act as a receptor for CXCL17 (PubMed:29068046, PubMed:29875152) Q9HCE5 reviewed METTL14 The effect of phosphorylation at Ser-399 is unclear. According to a report, phosphorylation at Ser-399 is important for interaction with METTL3: phosphorylated Ser-399 forms a salt bridge with 'Arg-471' of METTL3 (PubMed:27281194). According to another report, phosphorylation at Ser-399 does not affect interaction with METTL3 (PubMed:29348140) || The ability of METTL14 to have catalytic activity is unclear and a number of experimental evidence suggests that it has no methyltransferase activity by itself (PubMed:27281194, PubMed:27373337, PubMed:27627798). According to some reports, has some methyltransferase activity in vitro (PubMed:24316715). However, other studies showed that METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (PubMed:27281194, PubMed:27373337, PubMed:27627798). 3D-structure studies showed that METTL14 contains a degenerate active site that is unable to accommodate donor and acceptor substrates (PubMed:27627798) || A disulfide bond between Cys-338 and Cys-388 is observed in a structure (PubMed:27627798). Its existence is however unsure in vivo Q9HCE9 reviewed ANO8 Q9HCK5 reviewed AGO4 Q9HD15 reviewed SRA1 Q9HDX8 reviewed alo1 Q9HWF9 reviewed ftnA Was originally thought to be a bacterioferritin (PubMed:10984043). Its inability to bind heme shows it is actually a bacterial ferritin (PubMed:21574546) Q9HXN6 unreviewed Q9I2Y2 reviewed thrH Its ability to complement a strain lacking the homoserine kinase thrB gene suggested that it acts as a homoserine kinase (PubMed:10220164). The ability to rescue a thrB mutant is explained by the phosphoserine:homoserine phosphotransferase activity in presence of phosphoserine, in a mechanism different from homoserine kinase, suggesting it is inappropriate to define it as a homoserine kinase (PubMed:14699121) Q9I7I3 unreviewed CG17837 Lacks conserved residue(s) required for the propagation of feature annotation Q9I8A0 unreviewed WT1(+KTS) Q9I8A1 unreviewed WT1(-KTS) Q9I8D1 reviewed MYO6 Represents an unconventional myosin. This protein should not be confused with the conventional myosin-6 (MYH6) || Originally predicted to contain a coiled coil domain but generally accepted to contain a stable SAH domain instead Q9I912 unreviewed cry4 Q9I9N2 unreviewed badb Q9IAK8 reviewed tbx5a Q9IAV3 reviewed hhex Q9IAY5 reviewed NUDT16L1 Although strongly related to the nudix NUDT16 protein, lacks the Nudix box and is therefore not related to the rest of the family. Lacks a number of residues which are necessary for hydrolase activity and does not play a role in U8 snoRNA decapping activity Q9JHE8 reviewed Ninj2 Q9JHL4 reviewed Dbnl Q9JHN8 reviewed Whr1 Was originally reported to be a serine/threonine-protein kinase. However, later studies have shown that the protein does not have kinase activity and is involved in transcription-coupled nucleotide excision repair Q9JHS2 reviewed Hif3a Q9JHS6 reviewed Asic4 Q9JHU0 reviewed Dpysl5 Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure Q9JHW5 reviewed Vamp7 Q9JHY8 reviewed Lig1 Q9JI20 reviewed Adarb2 Although it is similar to the double-stranded RNA adenosine deaminases ADAR/ADAR1 and ADARB1/ADAR2 and capable of binding RNA, it lacks double-stranded RNA adenosine deaminase activity in vitro. Instead, it inhibits adenosine-to-inosine editing in vivo Q9JI59 reviewed Jam2 Q9JI99 reviewed Sgpp1 Q9JID2 reviewed Gna11 Q9JII6 reviewed Akr1a1 Q9JIL8 reviewed Rad50 Q9JIP4 reviewed Panx1 Q9JIY7 reviewed Nat8 Q9JIY8 reviewed Nat8f3 Q9JIZ0 reviewed Nat8f1 Q9JJ19 reviewed Nherf1 Q9JJS5 reviewed Sh3bp4 Q9JJT0 reviewed Rcl1 Q9JK66 reviewed Prkn Q9JKA8 reviewed Hcn3 Q9JKE1 reviewed Trem3 Q9JKE7 reviewed Tas2r41 This protein was previously referred to as T2R26 or T2R12 but is now considered to be the ortholog of human TAS2R41 Q9JKL5 reviewed Tesc The region of SLC9A1/NHE1 that interacts with CHP3 is conflicting: In human, interaction with SLC9A1/NHE1 has been reported via residues 507-549, the juxtamembrane region of the cytoplasmic C-terminus. However, another publication has reported interaction with SLC9A1/NHE1 via residues 637-820, the region of the cytoplasmic C-terminus more distal to the membrane Q9JKU6 reviewed Strbp Q9JKX6 reviewed Nudt5 Q9JLH7 reviewed Cdk5rap3 Q9JLJ1 reviewed Selenok Q9JLY0 reviewed Socs6 Q9JM53 reviewed Aifm1 Q9JM62 reviewed Reep6 Q9JMG2 reviewed C1galt1c1 Was originally assigned to be a glycosyltransferase Q9JMJ4 reviewed Prpf19 Q9LD90 reviewed CBF5 Q9LDC0 reviewed FKBP42 Q9LDV4 reviewed ALAAT2 Q9LDZ0 reviewed HSP70-10 Q9LE16 reviewed BRIX1-1 Q9LEZ1 reviewed SOB5 Q9LF27 reviewed WDR12 Q9LF98 reviewed FBA8 Q9LFA3 reviewed MDAR1 Q9LFH5 reviewed RPL12B Q9LFN6 reviewed RH56 Q9LFW1 reviewed RGP2 Q9LHG9 reviewed Q9LIB2 reviewed PHS1 Q9LIH9 reviewed RH51 Q9LIK0 reviewed PKP1 Q9LIK9 reviewed APS1 Q9LIN2 reviewed Q9LIR4 reviewed DHAD Q9LJ97 reviewed RAB28 Q9LJE4 reviewed CPN60B2 The Cpn60 chaperonin complex was previously shown to be required for folding of the NAD(P)H-quinone oxidoreductase subunit ndhH. However the corresponding paper has been retracted due to fraudulent image manipulation of some of the data Q9LJH8 reviewed UBP1C Q9LJU0 reviewed COBL10 Q9LJW3 reviewed NAC59 Q9LK09 reviewed SYP32 Q9LK25 reviewed PHB4 Q9LK34 reviewed UKL2 Q9LK43 reviewed TMK4 Q9LKA3 reviewed Q9LKA4 reviewed UBA2C Q9LKB9 reviewed XI-2 Q9LKL2 reviewed APRR1 Lacks the phospho-accepting Asp (here Glu-71), present in the receiver domain, which is one of the conserved features of the two-component response regulators (ARRs) family Q9LL84 reviewed LIG4 Q9LM02 reviewed SMT1 Q9LMI0 reviewed TPS7 Q9LMJ4 reviewed EXO70B2 Q9LMP7 reviewed GOS11 Q9LNC5 reviewed CLO Q9LNE3 reviewed Q9LPS1 reviewed HXK3 Q9LPW0 reviewed GAPA2 Q9LPZ1 reviewed MORF9 Q9LQ10 reviewed ACS10 Contains a Gln instead of a Glu in position 176 and a Phe residue instead of a Tyr in position 209; these residues being essential in substrate recognition by ACS enzymes Q9LQ12 reviewed 4CLL1 Q9LQ55 reviewed DRP2B Q9LQC8 reviewed ARF2-A Q9LQI9 reviewed UBP1B Q9LQL2 reviewed NPF7.3 Q9LQP1 unreviewed DSI-1VOC Lacks conserved residue(s) required for the propagation of feature annotation Q9LQT8 reviewed GAI Q9LQZ4 unreviewed Q9LR30 reviewed GGAT1 Q9LR47 reviewed IP5P6 Q9LRA7 reviewed TPS9 Q9LRR9 reviewed GLO1 Q9LRV9 reviewed PCMP-E89 Q9LRZ3 reviewed APUM24 Q9LRZ5 reviewed PLDZETA1 Q9LSA3 reviewed RPL30C Q9LSI9 reviewed BIR2 Nucleotide binding site is not accessible for binding to ATP-analogs Q9LSP9 reviewed CTL2 Q9LSQ5 reviewed FQR1 Q9LSW5 unreviewed MWF20.18 Q9LT92 unreviewed MJM18.3 Q9LTF2 reviewed RPS10C Q9LTJ1 reviewed MBD6 Q9LTV6 reviewed Was originally assigned as At3g12790 Q9LU05 reviewed PCAP2 Q9LUE6 reviewed RGP4 Q9LUG1 reviewed SEC23E Q9LUG5 reviewed Q9LUL2 reviewed WAG2 Q9LUT2 reviewed METK4 Q9LUW0 reviewed LOX5 Q9LV03 reviewed GLT1 Q9LV28 reviewed RACK1C Q9LVA0 reviewed BAG7 Q9LVB8 reviewed CXE20 Q9LVJ1 reviewed SBT1.4 Q9LVW7 reviewed CARA Q9LW20 reviewed SKL1 SKL1 does not possess shikimate kinase activity in vitro probably because it lacks the conserved active sites and substrate binding sites of the shikimate kinase family Q9LXC9 reviewed PPA6 Q9LXG1 reviewed RPS9B Q9LXS7 reviewed CSY1 Q9LXT5 unreviewed Q9LXZ4 unreviewed Q9LY46 reviewed ESK1 Q9LY75 reviewed CYP63 Q9LY78 unreviewed VPNB1 Q9LYB9 reviewed MBD4 Q9LYC1 reviewed GID1B Q9LYF8 unreviewed AGLU1 Q9LYK9 reviewed RPS26C Q9LYR4 unreviewed TRA2 Q9LYU7 reviewed CRN Q9LZ17 reviewed RPS17D Q9LZ41 reviewed RPL35D Q9LZ66 reviewed SIR Q9LZE4 reviewed FADS1 Lacks an Asp in position 296 necessary for diphosphatase activity Q9LZH9 reviewed RPL7AB Q9LZI2 reviewed UXS2 Q9LZM1 reviewed ORP3A Q9LZT4 reviewed EXLA1 Q9M0A5 reviewed GGP3 Q9M0D1 reviewed XTH19 Q9M0D2 reviewed XTH18 Q9M0X9 reviewed 4CLL7 Q9M1B4 reviewed SSL13 Q9M1J6 reviewed SSL9 Q9M1J7 reviewed SSL8 Q9M1P5 unreviewed ARFA1E Q9M2E0 reviewed RH12 Q9M2F1 reviewed RPS27B Q9M339 reviewed RPS3B Q9M384 reviewed SCR Q9M3C3 reviewed RPL23AB Q9M3G7 reviewed ATM Q9M401 reviewed BCAT3 Q9M4A1 reviewed SPO11-2 Q9M5J8 reviewed PGIP2 Q9M5J9 reviewed PGIP1 Q9M5K2 reviewed LPD2 Q9M5K3 reviewed LPD1 Q9M5P2 reviewed SCAMP3 Q9M658 reviewed MOM1 Q9M670 reviewed RTM2 Has been shown to be inactive in cv. Ct-1 and cv. Ga-0 (AC D5K211), cv. Bl-1 and cv. Sakata (AC D9UBX6), cv. Blh-1, cv. Pyl-1 and cv. Sha (AC D9UBX4), and cv. Ge-1 (AC D9UC01) due to naturally occurring sequence variation in these strains. The sequence shown is from strain cv. Columbia Q9M7Q7 reviewed PCNA Q9M885 reviewed RPS7B Q9M8K7 reviewed DSPTP1B Q9M8S6 reviewed SKOR Q9M8T0 reviewed Q9M8Z5 reviewed NSN1 Q9M8Z7 reviewed UGT80A2 Q9M9S3 reviewed WHY1 It is uncertain whether Met-1 or Met-10 is the initiator Q9MA41 reviewed CTL1 Q9MAA2 reviewed Q9MAA7 reviewed GID1A Q9MAB6 reviewed ISU2 Q9MAK9 reviewed RPT4B Q9MBH2 reviewed AIG2B Q9MZF4 reviewed DUOX1 The role of the N-terminal peroxidase-like domain is unclear. The domain has been shown in one study to have peroxidase activity when expressed in E.coli. However, another study showed that the isolated domain does not bind heme and has no intrinsic peroxidase activity Q9N0B5 reviewed TMEM266 Q9N0V3 reviewed ABCB11 Q9N2J8 reviewed Lacks the CX6CC and the CKS-17 domains Q9N363 reviewed dcap-1 Q9NAC7 unreviewed Q9NAH6 reviewed rsks-1 Q9NB04 reviewed Patj Was originally thought to be the Disks lost (Dlt) protein. However, PubMed:14667407 showed that it is not the case and renamed it Patj. This drastically changes the first conclusions drawn about its essential function, since the mutant used contained defects for another protein, which is now called Dlt. If its association with proteins involved in cell polarization complexes is clear, Patj is not essential since its absence apparently does not lead to important defects Q9NFT9 reviewed Hexl Although it belongs to the hexokinase family it lacks the residues for ATP substrate binding, suggesting it has no kinase activity Q9NFU0 reviewed Fmr1 Q9NHA8 reviewed GNBP3 Q9NHB0 reviewed GNBP1 Q9NHC7 unreviewed Ilk Q9NP58 reviewed ABCB6 To date, the intracellular localization of ABCB6 is a matter of debate, with conflicting reports suggesting mitochondrial (PubMed:10837493, PubMed:17006453, PubMed:17661442) or endolysosomal localization (PubMed:22655043, PubMed:25627919, PubMed:29940187, PubMed:31053883), therefore questioning the requirement of ABCB6 in the mitochondrial import of porphyrins Q9NP71 reviewed MLXIPL Q9NP78 reviewed ABCB9 Has also been detected in the endoplasmic reticulum but appears to be a lysosomal protein in vivo Q9NPD3 reviewed EXOSC4 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q9NQ94 reviewed A1CF Q9NQC1 reviewed JADE2 Q9NQG6 reviewed MIEF1 Was submitted as a Xenopus tropicalis sequence in INSDC entry BC090137. However, this sequence appears to be from human Q9NQT4 reviewed EXOSC5 The six exosome core subunits containing a RNase PH-domain are not phosphorolytically active Q9NQT5 reviewed EXOSC3 Q9NR22 reviewed PRMT8 Q9NR31 reviewed SAR1A Q9NRD9 reviewed DUOX1 The role of the N-terminal peroxidase-like domain is unclear. The domain has been shown in one study to have peroxidase activity when expressed in E.coli (PubMed:11514595). However, another study showed that the isolated domain does not bind heme and has no intrinsic peroxidase activity (PubMed:19460756) Q9NRG1 reviewed PRTFDC1 Lacks the conserved active site Asp and has no significant phosphoribosyltransferase activity Q9NRL2 reviewed BAZ1A Q9NRS6 reviewed SNX15 Q9NRY7 reviewed PLSCR2 Q9NS39 reviewed ADARB2 Although it is similar to the double-stranded RNA adenosine deaminases ADAR/ADAR1 and ADARB1/ADAR2 and capable of binding RNA, it lacks double-stranded RNA adenosine deaminase activity in vitro. Instead, it inhibits adenosine-to-inosine editing in vivo Q9NTG7 reviewed SIRT3 Q9NU19 reviewed TBC1D22B Q9NUU6 reviewed OTULINL Although highly similar to the deubiquitinase OTULIN, lacks the conserved active site Cys at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity Q9NUX5 reviewed POT1 Q9NV35 reviewed NUDT15 Q9NVE7 reviewed PANK4 Despite belonging to the type II pantothenate kinase family, the pantothenate kinase domain contains a Val residue at position 147 and a Trp residue at position 211 instead of the two conserved active site residues, Glu and Arg. Lacks pantothenate kinase activity Q9NVG8 reviewed TBC1D13 Q9NW15 reviewed ANO10 Q9NWR8 reviewed MCUB Q9NWS0 reviewed PIH1D1 Q9NXA8 reviewed SIRT5 Q9NXL9 reviewed MCM9 Q9NY91 reviewed SLC5A4 Q9NYB0 reviewed TERF2IP Was reported to participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair in the absence of TERF2 (PubMed:19763083). However, this probably does not corresponds to its primary function and experiments in mouse showed that it is dispensible for such process and is required for repression of homology-directed repair (HDR) Q9NYF0 reviewed DACT1 Q9NZ43 reviewed USE1 Q9NZG7 reviewed NINJ2 Q9NZJ9 reviewed NUDT4 Q9NZN1 reviewed IL1RAPL1 Q9NZQ7 reviewed CD274 Q9P0L0 reviewed VAPA Q9P0R6 reviewed GSKIP Q9P0V3 reviewed SH3BP4 Q9P1W3 reviewed TMEM63C Q9P1Z3 reviewed HCN3 Q9P267 reviewed MBD5 Q9P2A4 reviewed ABI3 Q9P2E5 reviewed CHPF2 Q9P2M4 reviewed TBC1D14 Q9P371 reviewed sst2 Q9P382 reviewed nup82 Q9P3W5 reviewed tel2 Q9P6J8 reviewed Although clearly a member of the adenine deaminase type 2 family, it lacks the conserved Glu active site residue in position 212 characteristic for this family. Its exact enzymatic activity is therefore unsure Q9P6Q6 reviewed pct1 Q9P7B8 reviewed arb1 Q9P7J2 reviewed xlf1 Q9P7N4 reviewed tad3 In contrast to other cytidine and deoxycytidylate deaminase, lacks the conserved Glu active site in position 213 which is replaced by a Val residue, suggesting that it acts as a regulatory subunit Q9P7Q6 reviewed mug51 Q9P7Q7 reviewed mak1 Q9P7T9 reviewed Q9P7V3 reviewed tsn1 Q9PRS8 reviewed Q9PT37 unreviewed Q9PTF7 unreviewed cxcr4b Lacks conserved residue(s) required for the propagation of feature annotation Q9PTX9 unreviewed exorh Lacks conserved residue(s) required for the propagation of feature annotation Q9PVF8 reviewed ctnna1 Q9PW28 reviewed eif4e1b Q9QUG3 reviewed Prnd Q9QUH3 reviewed Apoa5 Q9QUK6 reviewed Tlr4 In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity Q9QUR8 reviewed Sema7a The exact role in regulating T-cell function is under debate. According to (PubMed:16713976), SEMA7A-deficient mice are highly susceptible to contact hypersensitivity and experimental autoimmune encephalomyelitis. According to (PubMed:17377534) mice do not develop contact hypersensitivity, and are highly resistant to experimental autoimmune encephalomyelitis Q9QWI6 reviewed Srcin1 Q9QWJ9 reviewed Nrp1 Q9QWV9 reviewed Ccnt1 Q9QX05 reviewed Tlr4 In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity Q9QX69 reviewed Lancl1 Q9QXE4 reviewed Trp53inp1 Q9QXH4 reviewed Itgax Q9QXL7 reviewed Nme7 Q9QXQ7 reviewed Wnt5a Q9QXS8 reviewed Nat8f5 Q9QXU8 reviewed Dync1li1 Q9QXY2 reviewed Srcin1 Q9QY17 reviewed Pacsin2 Q9QY30 reviewed Abcb11 Q9QY93 reviewed Dctpp1 Q9QYC5 reviewed Gpr37l1 Has been reported to act as a receptor for prosaposin (PSAP). However, it has also been shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor Q9QYF1 reviewed Rdh11 Q9QYF3 reviewed Myo5a Q9QYH7 reviewed Ghrl PubMed:16284174 reports obestatin as ligand of GPR39 (PubMed:16284174). However, PubMed:17289961 and others are unable to reproduce these results (PubMed:17289961). It also seems to be unclear whether obestatin has opposite effects on food intake compared with ghrelin (PubMed:17289961) Q9QYJ4 reviewed Abcb9 Q9QYN5 reviewed Bcl10 Q9QYR6 reviewed Map1a Q9QYV0 reviewed Adam15 Q9QZA2 reviewed Pdcd6ip Q9QZC5 reviewed Grb7 Q9QZR5 reviewed Hipk2 Q9QZS3 reviewed Numb Q9R0C9 reviewed Sigmar1 Q9R0N3 reviewed Syt11 Q9R0N4 reviewed Syt10 Q9R0R1 reviewed Meltf Q9R0W5 reviewed Asic5 Q9R0Y1 reviewed Asic5 Q9R100 reviewed Cdh17 Q9R193 reviewed Atp1b4 Q9R1Q9 reviewed Atp6ap1 Q9R1S4 reviewed Xbp1 Q9R244 reviewed Trpc2 Pseudogene in humans, apes, and Old World monkeys Q9R283 reviewed Trpc2 Q9RY80 reviewed ddrB Q9RYZ9 unreviewed Q9S777 reviewed 4CL3 Q9S791 unreviewed Q9S7E9 reviewed GGAT2 Q9S7H3 reviewed CDC20-3 Q9S7J7 reviewed LHCB2.2 Q9S7S4 unreviewed Q9S7Y7 reviewed XYL1 Q9S850 reviewed SOX Lacks the conserved cytochrome b5 heme-binding domain present in other sulfite oxidases Q9SA14 reviewed IMDH3 Q9SA78 reviewed Q9SAI4 reviewed NIP6-1 Q9SAJ4 reviewed PGK3 Q9SB36 reviewed PCMP-E53 Q9SB47 reviewed SIC Q9SB92 reviewed WUS Q9SCK3 reviewed HP30-1 Q9SCV3 reviewed BGAL9 Q9SCW1 reviewed BGAL1 Q9SCX3 reviewed Q9SCY0 reviewed PGMP Q9SD04 reviewed SSL7 Q9SD05 reviewed SSL6 Q9SD07 reviewed SSL4 Q9SDS7 reviewed VHA-C Q9SEL3 unreviewed Glp1 Q9SEL6 reviewed VTI11 Q9SF35 reviewed RPS23A Q9SF53 reviewed RPL35A Q9SFU0 reviewed SEC24A Q9SFX3 reviewed OST1A Q9SG02 reviewed RDR6 Q9SGR6 unreviewed SKS5 Q9SGS4 reviewed CDSP32 Q9SGT7 unreviewed NOP56 Q9SHJ6 reviewed PMD2 Q9SHR7 reviewed LHCB2.1 Q9SHS7 reviewed BSL3 Q9SIB9 reviewed ACO3 Q9SID0 reviewed Q9SIE1 reviewed PAT Q9SIF2 reviewed HSP90-5 Q9SII6 reviewed PIX13 Q9SIK2 reviewed RPS25B Q9SIM4 reviewed RPL14A Q9SIP1 reviewed UP3 Q9SIP7 reviewed RPS3A Q9SIS3 reviewed MAP65-6 Q9SIU0 reviewed NAD-ME1 Q9SIU2 reviewed ABH1 Q9SIW2 reviewed DRD1 Q9SIW5 reviewed RPS25A Q9SJ36 reviewed RPS17B Q9SJF0 reviewed BSL2 Q9SJF3 reviewed Q9SJH7 reviewed CSY3 Q9SK22 reviewed RPS16A Q9SL95 reviewed MOT1 Q9SLF7 reviewed RPP2B Q9SLG8 reviewed SSL2 Q9SLH3 reviewed RGA Q9SLP6 unreviewed L-FNRI Q9SMT7 reviewed AAE3 Q9SMU8 reviewed PER34 Q9SMX3 reviewed VDAC3 Q9SN35 reviewed RABA1D Q9SN38 reviewed RLP51 Q9SQ64 reviewed COR2 COR2 does not seem to have codeinone reductase activity Q9SQG2 reviewed APY1 Q9SQI8 reviewed LTA2 Q9SQT8 reviewed EMB3004 Q9SQZ1 reviewed RPS17C Q9SR62 reviewed RLPH2 Q9SR73 reviewed RPS28A Q9SRD4 reviewed IGMT5 Q9SRE0 reviewed COG0212 Q9SRH5 reviewed VDAC1 Q9SRQ6 reviewed NPC3 Q9SS17 reviewed RPS24A Q9SSC9 reviewed AHP6 Lacks the conserved active histidine at position 83 that mediates the phosphotransfer. Shows a conserved HPt domain that may have some alternative degenerated phosphorelay role in cell signaling Q9SSD2 reviewed PRP8A Q9SSP9 unreviewed Q9SST3 unreviewed NHL22 Q9STF9 reviewed THA8L Q9STG9 reviewed ASE2 Q9STS1 reviewed ALDH10A9 Q9STW6 reviewed HSP70-6 Q9STX5 reviewed HSP90-7 Q9SU40 reviewed SKU5 Q9SU94 reviewed PRMT11 Q9SUB0 reviewed DOF4.3 Q9SUR6 reviewed CORI3 CORI3 was initially isolated by Lopukhina et al (PMID:11500565) as tyrosine aminotransferase (TAT). The authors also measured a TAT activity in vitro, even though relatively weak. Jones et al (PMID:12525491) showed that CORI3 possesses cystine lyase (CL) activity, but lacks TAT activity in vitro. In addition, CL activity is not inhibited by saturation of L-tyrosine in the medium. As CORI3 should bind L-tyrosine to catalyze TAT activity, this excludes a TAT activity for CORI3. Jones et al. made the statment that TAT activity resulted probably from residual native TAT-catalyzing proteins present in the purified preparations employed by Loupokhina et al Q9SUS3 reviewed BETAB-AD Q9SV68 reviewed CEQORH Q9SVD1 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation Q9SVM8 reviewed RBG2 Q9SVV6 reviewed TPK3 Q9SVY0 reviewed NRPA1 Q9SVY5 reviewed ZRK1 Q9SWW6 reviewed CESA7 Q9SX65 reviewed DHNAT1 Q9SX85 reviewed SEC3A Q9SX86 reviewed SEC3B Q9SXA1 reviewed PI4KA1 Q9SY09 reviewed SMD1B Q9SYG4 reviewed UBP1A Q9SYT0 reviewed ANN1 Q9SYU4 reviewed PEX10 Q9SZD4 reviewed RPT2A Q9T003 reviewed ASMT Q9T029 reviewed RPS25E Q9T043 reviewed RPL14B Q9T071 reviewed Q9T0A0 reviewed LACS4 Q9T0G2 reviewed CYTC-2 Q9T0J6 reviewed Q9TTU2 reviewed AK6 Q9TUH9 reviewed KCNE1 Q9U3D6 reviewed adr-1 Q9U3W6 reviewed mab-21 It is uncertain whether Met-1 or Met-7 is the initiator Q9U5W8 unreviewed Spn43Ab Q9UBB6 reviewed NCDN Q9UBK9 reviewed UXT Q9UBN7 reviewed HDAC6 Was originally thought to be a histone deacetylase (PubMed:10220385). However, subsequent work has shown that it is predominantly cytoplasmic and deacetylates a range of non-histone substrates (PubMed:12024216, PubMed:18606987, PubMed:20308065, PubMed:24882211, PubMed:26246421, PubMed:30538141, PubMed:31857589, PubMed:38534334, PubMed:39567688) Q9UBQ0 reviewed VPS29 Was originally believed to be a metal-dependent phosphatase but shown to lack catalytic activity; can bind metals with very low affinity suggesting that metal binding is not required for its function Q9UBR1 reviewed UPB1 The purified enzyme was shown to contain 0.5 zinc atoms per subunit, and sequence analysis was used to predict the zinc binding site (PubMed:11508704). The crystal structure indicates a lack of bound zinc ions, and shows that the residues that were predicted to bind zinc are too far apart in space to form a zinc binding site (PubMed:29976570) Q9UEU0 reviewed VTI1B Q9UGQ3 reviewed SLC2A6 Was initially thought to act as a glucose transporter (PubMed:10970791). However, later studies demonstrated that it does not transport glucose (PubMed:30431159) || Was named GLUT9 by a report, but this gene name has already been used for SLC2A9 Q9UHE8 reviewed STEAP1 Q9UHK0 reviewed NUFIP1 Q9UHN6 reviewed CEMIP2 A contradictory paper, using a cell-based assay with transfected 293T cell, reports that TMEM2 has no catalytic hyaluronic acid-degrading activity, although mouse TMEM2 exhibits hyaluronic acid-degrading activity in the same assay (PubMed:37196767). However, in Ref.12, authors claim a possible explanation for these contradictory results, they show that cell-based CEMIP2 hyaluronidase assays, as employed by Sato et al., can be confounded by the presence of unidentified factor(s) in cultures that suppress the hyaluronidase activity of CEMIP2 (PubMed:37527776) Q9UIF7 reviewed MUTYH Q9UIJ7 reviewed AK3 Q9UIV8 reviewed SERPINB13 Q9UJA3 reviewed MCM8 Was initially thought to play a role in DNA replication (PubMed:15684404). However, it was later shown that it is mainly involved in homologous recombination repair (PubMed:23401855) Q9UJY1 reviewed HSPB8 Was reported to have a protein kinase activity and to act as a Mn(2+)-dependent serine-threonine-specific protein kinase Q9UK55 reviewed SERPINA10 Q9UKF7 reviewed PITPNC1 Q9UKH3 reviewed ERVK-9 Q9UKK9 reviewed NUDT5 Q9UL18 reviewed AGO1 Q9ULB1 reviewed NRXN1 Q9ULI4 reviewed KIF26A In contrast to other kinesin-like proteins, residues required for ATPase activity are missing Q9ULL8 reviewed SHROOM4 Q9ULP9 reviewed TBC1D24 Q9ULQ1 reviewed TPCN1 Q9ULV4 reviewed CORO1C Q9UN42 reviewed ATP1B4 Q9UN81 reviewed L1RE1 Q9UNH7 reviewed SNX6 Q9UNL4 reviewed ING4 Q9UNS1 reviewed TIMELESS Q9UNW1 reviewed MINPP1 Q9UPU7 reviewed TBC1D2B Q9UPY3 reviewed DICER1 It is uncertain whether Met-1 or Met-11 is the initiator || A paper describing truncating mutations of TARBP2 in tumor cells and resultant effects on DICER1 stability and miRNA processing has been retracted, due to concerns of image duplication in some of the figures Q9UQV4 reviewed LAMP3 Q9URY0 reviewed ytm1 Q9URZ0 reviewed mel1 Q9URZ5 reviewed vps1 Q9USK2 reviewed set9 Q9USK6 reviewed cbp3 Q9USV1 reviewed sfr1 Q9UT12 reviewed Q9UT30 reviewed brr6 Q9UT35 reviewed gdp1 Q9UT49 reviewed cid13 Q9UT61 reviewed ams1 Q9UT72 reviewed rfp2 Q9UT79 reviewed msc1 Q9UTB4 reviewed mss51 Although no clear MSS51 ortholog is encoded in mammalian genomes, the mammalian MSS51/ZMYND17 protein of unknown function is significantly similar Q9UTE3 reviewed seb1 Q9UTK5 reviewed alm1 Q9UTM9 reviewed fap2 Q9UTN3 reviewed cid14 Q9UTN4 reviewed pfs2 Q9UTN9 reviewed atl1 Q9UTT1 reviewed ubp15 Q9UUE5 reviewed nup85 Q9UUJ6 reviewed ned1 Q9UWU1 reviewed Q9UYB2 reviewed sua5 Q9V3D4 reviewed Idgf2 Q9V3J4 reviewed Sec13 Q9V3V3 unreviewed Pez Q9V3Z1 reviewed trbl Q9V400 unreviewed Ilk Q9V422 reviewed dnt Although this protein belongs to the kinase superfamily, it lacks key residues required for catalytic activity, suggesting that it does not have kinase activity Q9V424 unreviewed MBD-like Q9V470 unreviewed ScsbetaG Q9V4L4 reviewed kappaB-Ras Q9V4Q0 reviewed Grl43a Q9V5C6 reviewed Prosalpha7 Q9V629 reviewed cuff In contrast to other members of the family, does not possess detectable exonuclease activity toward 5'-monophosphate RNA or pyrophosphohydrolase activity (PubMed:27292797). Lacks the conserved catalytic sites that bind the divalent metal cations required for ribonuclease activity Q9V730 reviewed ttv Q9VA12 reviewed Prosalpha3T Q9VA37 reviewed dj-1beta Q9VA48 unreviewed Spn100A Q9VA73 reviewed Aralar Q9VAH7 unreviewed yata Q9VAR0 unreviewed Dmel\CG1951 Q9VAR1 unreviewed eIF4E6 Q9VAS0 unreviewed Nepl20 Lacks conserved residue(s) required for the propagation of feature annotation Q9VAS1 unreviewed Nepl19 Lacks conserved residue(s) required for the propagation of feature annotation Q9VAS2 unreviewed Nepl18 Lacks conserved residue(s) required for the propagation of feature annotation Q9VAS4 unreviewed Nepl17 Lacks conserved residue(s) required for the propagation of feature annotation Q9VAT6 unreviewed intr Lacks conserved residue(s) required for the propagation of feature annotation Q9VAT7 unreviewed aqrs Lacks conserved residue(s) required for the propagation of feature annotation Q9VAT8 unreviewed Dmel\CG9997 Q9VB04 unreviewed btz Q9VB08 reviewed Sce Q9VB10 unreviewed Hsdl2 Q9VBF5 unreviewed Aldol Q9VBG5 unreviewed CG6069 Lacks conserved residue(s) required for the propagation of feature annotation Q9VBK8 unreviewed Sodq Q9VBP3 reviewed Tnks Q9VBX6 unreviewed Nepl16 Lacks conserved residue(s) required for the propagation of feature annotation Q9VC06 unreviewed Dmel\CG11771 Q9VCC6 unreviewed Dmel\CG6178 Q9VCP4 unreviewed CG13825 Q9VCT4 unreviewed klg Lacks conserved residue(s) required for the propagation of feature annotation Q9VCU1 unreviewed Nepl15 Lacks conserved residue(s) required for the propagation of feature annotation Q9VCU2 unreviewed Nepl14 Lacks conserved residue(s) required for the propagation of feature annotation Q9VCU3 unreviewed Nepl13 Lacks conserved residue(s) required for the propagation of feature annotation Q9VCV1 unreviewed CG6982 Q9VCY3 reviewed CSN6 Q9VD23 unreviewed Pykl1 Q9VD87 unreviewed Dmel\CG5849 Q9VDE4 reviewed Bdbt Q9VDQ9 unreviewed Sordl Q9VEA9 unreviewed Rps6kc1 Q9VEC6 unreviewed wrd Q9VEH5 unreviewed AttD Q9VET9 unreviewed Decay Q9VEZ0 unreviewed Mhcl Lacks conserved residue(s) required for the propagation of feature annotation Q9VF17 unreviewed CG11846 Q9VF24 unreviewed cv-d Lacks conserved residue(s) required for the propagation of feature annotation Q9VFE2 unreviewed Sdr Q9VFG4 unreviewed Pykl3 Q9VG44 unreviewed Dmel\CG6225 Q9VG97 reviewed GstD3 In vitro shows no activity towards glutathione. Lacks 16 amino acids at the N-terminus including a glutathione binding site known to be important for catalysis Q9VGH9 unreviewed Sbf Q9VGJ4 unreviewed Dmel\CG14717 Q9VGZ3 unreviewed Irp-1B Q9VH46 unreviewed Spn85F Q9VH89 reviewed dmt Q9VH96 unreviewed Nepl12 Lacks conserved residue(s) required for the propagation of feature annotation Q9VHB7 unreviewed MBD-like Q9VHC3 reviewed by Lacks the phosphatase domain found in other PTEN phosphatase protein family members so is unlikely to have phosphatase activity Q9VHT4 reviewed Gfr Q9VIB1 unreviewed alpha-Est9 Q9VIB3 unreviewed alpha-Est8 Q9VIC3 unreviewed alpha-Est1 Q9VIP7 reviewed bwa Ortholog of mammalian alkaline ceramidases that lacks ceramidase (EC:3.5.1.23) activity (PubMed:21148295). There is evidence of increased ceramidase activity in cells overexpressing this protein, though this could be due to regulation of expression or activity of other proteins involved in this pathway (PubMed:20112046, PubMed:21148295). The CREST motif amino acids that form the Zn(2+) binding active site in mammalian alkaline ceramidases are conserved Q9VJ33 reviewed Nedd8 Q9VJ57 unreviewed Grip71 Q9VJ95 unreviewed Ptp36E Lacks conserved residue(s) required for the propagation of feature annotation Q9VJD6 unreviewed Dmel\CG18563 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJD7 unreviewed SPH93 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJH0 unreviewed Nepl9 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJI5 unreviewed yellow-b Q9VJI8 unreviewed ChLD3 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJJ0 unreviewed Prosbeta4 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJK5 unreviewed Nepl8 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJN5 reviewed wek Q9VJQ3 unreviewed yellow-c Q9VJR8 unreviewed Dmel\CG4650 Lacks conserved residue(s) required for the propagation of feature annotation Q9VJS8 reviewed elB Q9VJV2 unreviewed Ance-2 Q9VJZ8 unreviewed c-SPH166 Lacks conserved residue(s) required for the propagation of feature annotation Q9VK07 reviewed Uvrag Q9VK14 unreviewed Prosalpha6T Q9VK34 reviewed Sirt1 Q9VK72 unreviewed Nepl7 Lacks conserved residue(s) required for the propagation of feature annotation Q9VKC9 reviewed dmGlut Q9VKD7 reviewed zuc Q9VKF7 unreviewed Galml3 Q9VKK5 unreviewed AstC Q9VL01 unreviewed Sph35 Lacks conserved residue(s) required for the propagation of feature annotation Q9VL32 reviewed Sur Q9VL44 unreviewed Spn31A Q9VL83 unreviewed IP3K1 Q9VLA3 unreviewed Dmel\CG4382 Q9VLC1 reviewed FucTB No 3-alpha-L-fucosyltransferase activity detected in vitro towards glycoprotein N-glycans bearing various terminal residues Q9VLQ9 unreviewed Snx6 Q9VLV3 unreviewed Spn28Db Q9VLW2 reviewed Q9VM18 unreviewed Tppl Q9VM74 unreviewed Nha1 Q9VM90 reviewed meng Q9VMA3 reviewed cup Q9VME2 unreviewed Nepl6 Lacks conserved residue(s) required for the propagation of feature annotation Q9VME3 unreviewed Nepl5 Lacks conserved residue(s) required for the propagation of feature annotation Q9VME6 unreviewed Nepl4 Lacks conserved residue(s) required for the propagation of feature annotation Q9VMU2 unreviewed Dmel\CG5828 Q9VMU6 unreviewed Nepl3 Lacks conserved residue(s) required for the propagation of feature annotation Q9VMX6 reviewed Marcal1 Q9VN01 unreviewed Nepl11 Lacks conserved residue(s) required for the propagation of feature annotation Q9VNA5 reviewed Prosbeta7 Q9VNC1 unreviewed mRpL44 Q9VNG6 unreviewed Rab23 Q9VNW4 unreviewed G6pdl Q9VNZ9 unreviewed Pykl5 Q9VP43 unreviewed CG12973 Q9VPB7 unreviewed Pcif1 Q9VPG0 unreviewed Dmel\CG5282 Lacks conserved residue(s) required for the propagation of feature annotation Q9VPH9 unreviewed Spn77Bc Q9VPV8 unreviewed IA-2 Lacks conserved residue(s) required for the propagation of feature annotation Q9VPW2 unreviewed Atg4a Q9VPZ5 unreviewed CT16527 Q9VQ75 unreviewed Dmel\CG4259 Lacks conserved residue(s) required for the propagation of feature annotation Q9VQA3 unreviewed anon-SAGE:Wang-110 Lacks conserved residue(s) required for the propagation of feature annotation Q9VQA4 unreviewed Dmel\CG4271 Lacks conserved residue(s) required for the propagation of feature annotation Q9VQE5 reviewed Prosbeta4R2 Q9VQH0 unreviewed Pykl2 Q9VQH8 unreviewed c-SPH125 Lacks conserved residue(s) required for the propagation of feature annotation Q9VQH9 unreviewed c-SPH94 Lacks conserved residue(s) required for the propagation of feature annotation Q9VQK9 reviewed GABPI Shares similarity with vertebrate DHHC palmitoyltransferase proteins but lacks the active site Cys within the DHHC motif and instead has a Ser. It is unclear if this can form a S-palmitoyl serine intermediate required for acyltransferase activity Q9VQQ6 unreviewed Snx1 Q9VR20 reviewed Both this protein and otu are putative deubiquitinases with homology to other OTU-type deubiquitinases (EC:3.4.19.12), although the nucleophile cysteine residue of its active site has been mutated to serine (Ser-40). Initial characterization showed a lack of deubiquitinase activity towards all diubiquitin molecules and long K48- and K63- linked ubiquitin chains, even when the nucleophile was mutated back to a cysteine (PubMed:26588485). Subsequent characterization using a more sensitive assay did detect low level deubiquitinase activity for otu (this protein was not retested). Deubiquitinases that are serine proteases instead of cysteine- or metallo- proteases have to date not been described Q9VR69 unreviewed Cda4 Q9VRE9 unreviewed Dmel\CG1503 Q9VRK6 unreviewed Dmel\CG4669 Q9VRK9 unreviewed Klp64D Q9VRL1 unreviewed Uev1A Lacks conserved residue(s) required for the propagation of feature annotation Q9VRP2 unreviewed BEST:CK00496 Q9VS71 unreviewed sphinx2 Lacks conserved residue(s) required for the propagation of feature annotation Q9VS97 reviewed PGRP-SD Q9VSH0 reviewed Homolog of vertebrate CGAS/Cyclic GMP-AMP synthase but lacks any detectable ability to activate STING in response to dsDNA (PubMed:34261128). Lacks the zinc-ribbon domain and positively charged N-terminus essential for DNA binding Q9VSL2 unreviewed GstO3 Q9VSL5 unreviewed GstO2 Q9VSL6 unreviewed GstO1 Q9VSM6 reviewed S-Lap1 Although it belongs to the peptidase M17 family, lacks the active site Arg residue and has no aminopeptidase activity Q9VSM7 reviewed S-Lap2 Although it belongs to the peptidase M17 family, lacks the active site Arg residue, suggesting it has no aminopeptidase activity Q9VSM8 unreviewed GAPsec Q9VSV4 unreviewed Dmel\CG4477 Lacks conserved residue(s) required for the propagation of feature annotation Q9VT00 reviewed Jarid2 Q9VT15 unreviewed Dmel\CG3088 Lacks conserved residue(s) required for the propagation of feature annotation Q9VT51 reviewed Ilp2 Q9VT52 reviewed Ilp3 Q9VTI3 unreviewed Khkl2 Q9VTL4 unreviewed Dmel\CG6071 Q9VTM5 reviewed mtTFB1 Q9VTZ5 reviewed Tsf2 Q9VU14 unreviewed Atg1 Q9VU31 reviewed It is unclear whether the protein is involved in the piRNA metabolic process. The absence of phenotypes in flies suggests that this function is not conserved Q9VU78 unreviewed Dmel\CG10116 Q9VU79 unreviewed EHR Q9VU84 reviewed Abp1 Q9VU94 unreviewed Hml Lacks conserved residue(s) required for the propagation of feature annotation Q9VUB5 reviewed upSET Q9VUH6 unreviewed mop Q9VUX3 reviewed Notum The molecular function of NOTUM has remained unclear for many years. It was initially thought to hydrolyze glycosaminoglycan (GAG) chains of glypicans, thereby affecting glypicans ability to interact with Wnt ligands (PubMed:12000788, PubMed:12015973). It was later reported to trigger glypican shedding, by mediating cleavage of their GPI-anchor (PubMed:15469839). However, while NOTUM specifically inhibit the Wnt signaling pathway, more pleiotropic effects would be expected from an enzyme affecting glypicans. It was finally shown that it requires glypicans to suppress Wnt signaling, but does not cleave their GPI-anchor (PubMed:25731175). It acts by mediating depalmitoleoylation of WNT proteins, impairing WNT binding to frizzled receptors (PubMed:25731175) Q9VV38 unreviewed Dmel\CG4998 Lacks conserved residue(s) required for the propagation of feature annotation Q9VV75 unreviewed UQCR-C2 Q9VVA7 unreviewed TSG101 Q9VVH0 unreviewed Pykl4 Q9VVI3 reviewed Nedd4 According to some authors (PubMed:12165468) it is involved in axon guidance by promoting ubiquitination of comm and subsequent endocytosis of the comm/robo complex. However, according to others (PubMed:15657595), it is not the case Q9VVP4 unreviewed Tktl Q9VVR4 reviewed GNBP2 Q9VVS1 unreviewed Dic4 Q9VVS6 unreviewed Atg3 Q9VVT2 reviewed Indy Q9VVV0 unreviewed Dmel\CG18223 Lacks conserved residue(s) required for the propagation of feature annotation Q9VVW1 reviewed Acp76A Q9VVX9 unreviewed SPH199 Lacks conserved residue(s) required for the propagation of feature annotation Q9VW15 reviewed ash1 Was reported to trimethylate H3 'Lys-9' and H4 'Lys-20' (PubMed:12397363). Was also reported to bind non-coding RNAs of trithorax response element (TRE) (PubMed:16497925). However, both papers were retracted because some data, results and conclusions are not reliable Q9VW23 unreviewed ms(3)76Cc Q9VW78 reviewed Ir76b Was initially characterized as a conventional ionotropic receptor with sodium channel activity (PubMed:23766326). However, it was later shown that it rather acts as a coreceptor of conventional ionotropic receptors rather than a ion channel (PubMed:27982028) Q9VW82 unreviewed Khkl1 Q9VWB4 unreviewed Spn77Bb Q9VWP1 unreviewed Usp39 Lacks conserved residue(s) required for the propagation of feature annotation Q9VWU0 unreviewed Dmel\CG15046 Q9VWV6 unreviewed Tsf1 Lacks conserved residue(s) required for the propagation of feature annotation Q9VWW0 reviewed CrebB Q9VX17 unreviewed Dmel\CG6398 Q9VX86 unreviewed Cg8945 Lacks conserved residue(s) required for the propagation of feature annotation Q9VX90 unreviewed CG34326 Q9VXC5 unreviewed SPH161 Lacks conserved residue(s) required for the propagation of feature annotation Q9VXC6 unreviewed Dmel\CG4653 Lacks conserved residue(s) required for the propagation of feature annotation Q9VXC7 unreviewed Dmel\CG9673 Lacks conserved residue(s) required for the propagation of feature annotation Q9VXC8 unreviewed sphe Lacks conserved residue(s) required for the propagation of feature annotation Q9VXH6 reviewed CalpC Q9VXL1 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation Q9VXN9 reviewed PGRP-LE Q9VXP4 reviewed Paf-AHalpha Although strongly related to acetylglycerophosphocholine esterase enzymes, it lacks the active site and has no lipase activity Q9VY15 unreviewed Dmel\CG14411 Q9VY83 unreviewed Galml2 Q9VYH2 unreviewed Chpf Q9VYX7 reviewed PGRP-SA Although suggested, the interaction with GNBP1 has not been experimentally demonstrated Q9VZ07 unreviewed Kap3 Q9VZ32 unreviewed xgr Q9VZH2 reviewed mas Lacks the conserved Ser residue within the catalytic triad which is replaced by a Gly residue, probably resulting in a loss of proteolytic activity Q9VZI5 unreviewed SPH97 Lacks conserved residue(s) required for the propagation of feature annotation Q9VZM5 reviewed PIG-B Q9VZQ8 unreviewed Gtpx Lacks conserved residue(s) required for the propagation of feature annotation Q9VZV9 unreviewed Dmel\CG1271 Q9VZX9 reviewed AhcyL1 Although it belongs to the adenosylhomocysteinase family, recombinant mouse homolog AHCYL1 expressed in bacteria shows no hydrolase activity, suggesting that Drosophila AhcyL1 may also lack this activity Q9W0F6 reviewed FucTD No 3-alpha-L-fucosyltransferase activity detected in vitro towards glycoprotein N-glycans bearing various terminal residues Q9W0H3 reviewed sturkopf The catalytic activity is unsure despite catalytic sites being conserved (PubMed:23525007, PubMed:27836991). Lacks cholesterol esterase activity when overexpressed in S2 cells (PubMed:27836991). The murine ortholog does have cholesterol esterase activity, although the activity is so low that it may be undetectable under certain experimental conditions or masked by other cellular cholesterol esterases (By similarity). Lacks lipolytic activity towards trioleoylglycerol, dioleoylglycerol or monooleoylglycerol when overexpressed in COS-7 cells or S2 cells (PubMed:23525007, PubMed:27836991) Q9W0K0 reviewed Aplip1 Q9W0X9 unreviewed CT12588 Q9W0Y6 reviewed pain Q9W0Z1 unreviewed Ance-5 Lacks conserved residue(s) required for the propagation of feature annotation Q9W138 reviewed Was originally thought to function as a nutrient sensor for methionine, inhibiting the TORC1 signaling pathway in the absence of S-adenosyl-L-methionine-binding (PubMed:29123071, PubMed:35776786). Subsequent studies showed that this conclusion may have been based on RNAi-mediated experimental artifacts and instead ascribe this function to the methyltransferase unmet (PubMed:38514639). The involvement of Samtor in this process in Diptera, if any, remains unknown Q9W174 unreviewed Dmel\CG15873 Lacks conserved residue(s) required for the propagation of feature annotation Q9W1F6 unreviewed fzr2 Q9W1H5 unreviewed DCP1 Q9W1I2 reviewed bgcn Q9W1M7 unreviewed Pi3K59F Lacks conserved residue(s) required for the propagation of feature annotation Q9W1W5 unreviewed SPH195 Lacks conserved residue(s) required for the propagation of feature annotation Q9W1Z9 unreviewed SPH182 Lacks conserved residue(s) required for the propagation of feature annotation Q9W215 unreviewed RYBP Q9W2E7 reviewed Rae1 Q9W2G1 unreviewed SP37 Lacks conserved residue(s) required for the propagation of feature annotation Q9W2M4 unreviewed Dmel\CG10527 Q9W2P1 unreviewed Dmel\CG3216 Q9W2S7 unreviewed pepCG2111 Q9W2S8 unreviewed Dmel\CG9806 Q9W303 reviewed Idgf4 Q9W328 reviewed Lst8 Q9W3H0 unreviewed SPH198 Lacks conserved residue(s) required for the propagation of feature annotation Q9W3H6 unreviewed sdt Q9W3H7 unreviewed sdt Q9W3H8 unreviewed sdt Q9W3I9 unreviewed Traf6 Q9W3R8 unreviewed Dmel\CG2059 Q9W3W5 reviewed shf Q9W429 reviewed Efr Q9W452 unreviewed Dmel\CG6067 Lacks conserved residue(s) required for the propagation of feature annotation Q9W477 unreviewed CG15768 Lacks conserved residue(s) required for the propagation of feature annotation Q9W4B8 unreviewed frma Lacks conserved residue(s) required for the propagation of feature annotation Q9W4F8 unreviewed Dmel\CG4041 Q9W4H9 unreviewed fzr Q9W4W6 unreviewed Ugalt Q9W552 reviewed Vps26 Q9W698 reviewed accs Similar to plant 1-aminocyclopropane-1-carboxylate synthases but lacks a number of residues which are necessary for activity Q9WTN5 reviewed Tpcn1 Q9WTQ6 reviewed Trib3 The role of this protein in Akt activation has been demonstrated by Du et al for the mouse ortholog but PubMed:15469416 has not been able to reproduce the result in rat hepatocytes Q9WTR1 reviewed Trpv2 Q9WTV1 reviewed Chi3l1 Although it belongs to the glycosyl hydrolase 18 family, Leu-138 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity Q9WTW7 reviewed Slc23a1 Q9WTY0 reviewed Aqp6 Q9WTY4 reviewed Aqp5 Q9WU38 reviewed Scnn1b Q9WU39 reviewed Scnn1g Q9WU61 reviewed Clcc1 Q9WUD2 reviewed Trpv2 Q9WUF4 reviewed Vamp8 Q9WUS0 reviewed Ak4 Q9WUZ9 reviewed Entpd5 Q9WV07 reviewed Aloxe3 Q9WV56 reviewed Gdf2 Can promote osteogenic differentiation in vitro (PubMed:25751889). This is probably not physiologically relevant Q9WV57 reviewed Mpeg1 Q9WVC1 reviewed Slit2 Q9WVE8 reviewed Pacsin2 Q9WVJ4 reviewed Synj2bp Q9WVK3 reviewed Pecr Q9WVS6 reviewed Prkn Q9XF04 reviewed CLV3 Q9XF59 reviewed PIP1-2 Q9XF87 reviewed LHCB2.4 Q9XFH9 reviewed Q9XHV0 reviewed MYB80 Q9XI01 reviewed PDIL1-1 Q9XI87 reviewed VIK Q9XIE2 reviewed ABCG36 Q9XIG1 reviewed UGT80B1 Q9XIJ0 unreviewed Q9XSC2 reviewed SLC2A3 Q9XSC5 reviewed CLU Q9XSP1 reviewed KCNE1 Q9XX42 unreviewed Q9XYN7 reviewed Prosbeta3 Q9XZ06 reviewed Nup93-1 Q9XZ10 unreviewed Vha100-1 Q9XZ14 reviewed goe Q9XZJ4 reviewed Prosalpha1 Q9Y0Y6 reviewed Madm Q9Y106 reviewed It is uncertain whether Met-1 or Met-7 is the initiator Q9Y136 unreviewed Nepl21 Lacks conserved residue(s) required for the propagation of feature annotation Q9Y165 unreviewed morgue Lacks conserved residue(s) required for the propagation of feature annotation Q9Y264 reviewed ANGPT4 Q9Y2H2 reviewed INPP5F INPP5F has been initially described as an inositol polyphosphate 5-phosphatase Q9Y2I7 reviewed PIKFYVE Q9Y2L1 reviewed DIS3 Q9Y303 reviewed AMDHD2 Q9Y3B2 reviewed EXOSC1 Q9Y3D8 reviewed AK6 AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species Q9Y3E7 reviewed CHMP3 Q9Y3P9 reviewed RABGAP1 Q9Y3Z3 reviewed SAMHD1 Was intially thought to be allosterically stimulated by dGTP (PubMed:22056990, PubMed:24141705, PubMed:24217394). However, it was later shown that it is allosterically activated and regulated via the combined actions of GTP and dNTPs (dATP, dGTP, dTTP and dCTP), which bind two separate binding sites (PubMed:25267621, PubMed:25288794, PubMed:25760601) || Phosphorylation at Thr-592 was initially thought to impair ability to restrict infection by viruses without affecting the deoxynucleoside triphosphate (dNTPase) activity (PubMed:23601106). However, it was later shown that phosphorylation reduces the stability of the homotetramer, leading to impair the dNTPase activity (PubMed:26294762, PubMed:26431200) || Was initially thought to have 3'-5' exonuclease activity, acting on single-stranded RNA (PubMed:23364794, PubMed:25038827). A publication also reported some DNA 3'-5' exonuclease activity (PubMed:23364794). However, it was later shown that SAMHD1 does not possess DNA and/or RNA exonuclease activities and that these activities are due to contamination during the purification process that can be removed after chromatography steps (PubMed:26101257). The exonuclease activity observed was maybe due to the presence of MRE11 during the purification steps (PubMed:29670289) Q9Y446 reviewed PKP3 Q9Y468 reviewed L3MBTL1 Q9Y471 reviewed CMAHP An Alu-mediated mutation of this gene occured in a common ancestor of Homo sapiens and Homo sapiens neanderthalis, approximately 2.1-2.2 million years ago, before brain expansion. It is generally accepted that the product of this gene, if any, is catalytically inactive as suggested by the absence of CMP-Neu5Gc sialic acid in human, while it is abundantly expressed at the surface of many cells in other vertebrates. The gene is however, significantly transcribed and the product described here might be expressed in vivo (PubMed:19890979). The putative protein is N-terminally truncated compared to orthologs and lacks a region probably essential to the CMP-N-acetylneuraminate monooxygenase activity Q9Y4A5 reviewed TRRAP Q9Y4C4 reviewed MFHAS1 Q9Y4G8 reviewed RAPGEF2 Q9Y4I1 reviewed MYO5A Q9Y4P8 reviewed WIPI2 Q9Y4R7 reviewed TTLL3 TTLL3 and TTLL8 monoglycylase-mediated glycylation of tubulin was initially reported to play a role in ependymal motile ciliary maintenance (By similarity). However, contradictory results were later observed (By similarity) Q9Y4X5 reviewed ARIH1 The RING-type 2 zinc finger was initially reported to only bind 1 zinc ion instead of 2 compared to classical RING-types (PubMed:15236971). But it was later shown that it is not the case and binds 2 zinc ions (PubMed:23707686, PubMed:24058416) Q9Y547 reviewed IFT25 Was initially classified as a member of the small heat shock family protein. However, it was later shown that it is not the case (PubMed:19921466) Q9Y580 reviewed RBM7 Q9Y5A9 reviewed YTHDF2 The role of YTHDF2 and N6-methyladenosine (m6A) in virus expression and replication is unclear (PubMed:29109479, PubMed:29447282, PubMed:29659627, PubMed:30559377). According to some reports, YTHDF2 promotes viral gene expression and replication of polyomavirus SV40 and herpesvirus (KSHV) by binding to N6-methyladenosine (m6A)-containing viral RNAs (PubMed:29447282, PubMed:29659627). Another report however suggests that YTHDF2 regulates virus expression and replication indirectly, via its ability to inhibit the type I interferon response, thereby promoting virus expression (PubMed:30559377). Indirect regulation via inhibition of type I interferon response might explain why contradictory results have been reported for its role in KSHV virus replication (PubMed:29109479, PubMed:29659627) || Previous studies suggested the 3 different paralogs (YTHDF1, YTHDF2 and YTHDF3) have unique functions with limited redundancy (PubMed:26046440). However, later studies showed that YTHDF1, YTHDF2 and YTHDF3 paralogs have redundant functions to a profound extent and directly promote degradation of m6A-containing mRNAs (PubMed:32492408) Q9Y5B8 reviewed NME7 Q9Y5N5 reviewed HEMK2 Was reported to have N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:30017583). The existence of N(6)-methyladenosine on DNA is unclear in mammals (PubMed:32203414). According to a report, the majority of N(6)-methyladenosine in DNA originates from RNA catabolism via a nucleotide salvage pathway and is misincorporated by DNA polymerases, arguing against a role as epigenetic DNA mark in mammalian cells (PubMed:32203414). Moreover, subsequent studies could not confirm the role of HEMK2 as a N(6)-adenine-specific DNA methyltransferase (PubMed:30392959, PubMed:31632689, PubMed:31636962) Q9Y5Y3 reviewed GPR45 Although it is part of the G protein-coupled receptor 1 family, does not act as a canonical G protein-coupled receptor: does not promote the exchange of GDP for GTP on G(s) protein but mediates G(s) translocation into primary cilia Q9Y6D6 reviewed ARFGEF1 Q9Y6E7 reviewed SIRT4 Q9Y6F1 reviewed PARP3 Q9Y6G9 reviewed DYNC1LI1 Q9Y6Q1 reviewed CAPN6 Q9Y6S9 reviewed RPS6KL1 Q9Y6Z9 reviewed Was previously thought to exhibit sorbose reductase activity based on similarity to C.albicans SOU1, however, S.pombe cannot assimilate L-sorbitol so the enzyme is unlikely to have this precise function Q9Y7I8 reviewed zuo1 Q9Y7J4 reviewed arc3 Q9Y7L4 reviewed exo5 Q9Y7Q2 reviewed gst1 Q9Y7Q6 reviewed set7 Q9YGD6 unreviewed Q9YH12 reviewed lsm14 Q9YHE8 reviewed tcf7l1a Q9Z0E0 reviewed Ncdn Q9Z0F3 reviewed Bcl2l10 Q9Z0H7 reviewed Bcl10 Q9Z0K8 reviewed Vnn1 Q9Z0M4 reviewed Cd46 Q9Z0W5 reviewed Pacsin1 Q9Z100 reviewed Cpxm1 Q9Z139 reviewed Ror1 The kinase domain has very low catalytic activity in vitro. Does not bind ATP Q9Z148 reviewed Ehmt2 Thought to interact with MSX1. However the paper has been retracted over concerns of image tampering || NG36 and G9a were originally thought to derive from two separate genes Q9Z158 reviewed Stx17 Q9Z1E1 reviewed Flot1 Q9Z1L4 reviewed Rs1 Q9Z1N9 reviewed Unc13b Q9Z1P2 reviewed Actn1 Q9Z1P4 reviewed Lgr5 Q9Z1T6 reviewed Pikfyve Q9Z209 reviewed LAYN Q9Z218 reviewed Dpp6 Q9Z255 reviewed Ube2a Q9Z269 reviewed Vapb Q9Z270 reviewed Vapa Q9Z2A6 reviewed Mapk15 Q9Z2D8 reviewed Mbd3 Q9Z2E1 reviewed Mbd2 Q9Z2E2 reviewed Mbd1 Q9Z2H4 reviewed Lgr4 Q9Z2I8 reviewed Suclg2 Q9Z2L6 reviewed Minpp1 Q9Z2Q3 reviewed Hyal2 Q9Z2S9 reviewed Flot2 Q9Z2T2 reviewed Kcnk1 Q9Z2V5 reviewed Hdac6 Was originally thought to be a histone deacetylase (PubMed:9891014). However, subsequent work has shown that it is predominantly cytoplasmic and deacetylates a range of non-histone substrates (PubMed:12606581, PubMed:19893491, PubMed:26746851, PubMed:27737934) Q9Z2Y1 reviewed Timeless Q9ZNS2 reviewed GH3.10 Q9ZP06 reviewed Q9ZPE7 reviewed EXO Q9ZPI5 reviewed MFP2 Q9ZR37 reviewed DSPTP1 Q9ZRW8 reviewed GSTU19 Q9ZSY2 reviewed ATJ15 Q9ZT82 reviewed CALS12 Q9ZT91 reviewed TUFA Q9ZTA1 reviewed AOP3 AOP1, AOP2 and AOP3 are found in tandem and inverted duplications on chromosome IV and encode 2-oxoglutarate-dependent dioxygenases involved in glucosinolates biosynthesis. In cv. Columbia, AOP2 (AC Q9ZTA2) cDNA contains a 5-bp deletion that leads to a non-functional protein and AOP3 (AC Q9ZTA1) is not expressed. The functional and expressed alleles for AOP2 (AC Q945B5) and AOP3 (AC Q945B4) are found in cv. Cvi and cv. Landsberg erecta, respectively. No ecotype coexpresses both AOP2 and AOP3 genes. The catalytic role of AOP1 is still uncertain (PubMed:11251105) Q9ZU97 reviewed VAC14 Q9ZUF6 reviewed SBT1.8 Q9ZV48 reviewed TPS11 Q9ZVA2 reviewed Q9ZVC3 unreviewed Q9ZVD5 reviewed AGO4 Q9ZVH4 reviewed CUL3A Q9ZVH8 reviewed TFIIS Q9ZVL3 reviewed NFYC3 Q9ZVQ2 unreviewed Q9ZVS4 unreviewed SAP2 Lacks conserved residue(s) required for the propagation of feature annotation Q9ZW07 reviewed APUM1 Q9ZW35 reviewed PCNA2 Q9ZW76 reviewed POP4 Q9ZWJ9 reviewed ARR2 R4GA88 unreviewed JARID2 Lacks conserved residue(s) required for the propagation of feature annotation R4GD12 unreviewed HGF Lacks conserved residue(s) required for the propagation of feature annotation S4S1V9 reviewed Although it belongs to the glycosyl hydrolase 18 family, Pro-125 is present instead of the conserved Glu which is an active site residue. Therefore this protein lacks chitinase activity T1EER4 unreviewed 20195066 T1EEU8 unreviewed 20195100 T1EGG1 unreviewed 20195663 T1EMG7 unreviewed 20197767 Lacks conserved residue(s) required for the propagation of feature annotation T1ENI4 unreviewed 20198134 T1FG29 unreviewed 20207778 T1FNT9 unreviewed 20210486 T1FP33 unreviewed 20210580 T1FRT6 unreviewed 20211533 T1FSP2 unreviewed 20211839 T1FU97 unreviewed 20212393 T1FV67 unreviewed 20212713 T1FVH6 unreviewed 20212822 T1FVH7 unreviewed 20212823 T1FVH8 unreviewed 20212824 T1FVH9 unreviewed 20212825 T1FVI0 unreviewed 20212826 T1FVI1 unreviewed 20212827 T1FVX1 unreviewed 20212967 Lacks conserved residue(s) required for the propagation of feature annotation T1G763 unreviewed 20216910 U3EWQ0 unreviewed MLC1 U3H042 reviewed sos7 U3KMC4 unreviewed U3KPV4 reviewed A3GALT2 According to a report, the spliced A3GALT2 mRNA is not detected in human tissues (PubMed:18630988). The functional activity of human A3GALT2 tested by expressing a chimeric protein containing the catalytic domain of human A3GALT2 is unable to synthesize isogloboside 3 (iGb3). Futhermore mutagenesis experiments in rat, show that the mutant 'Asn-253' of human A3GALT2 completely eliminates alpha-1,3-galactosyltransferase activity (PubMed:18630988) U5CXX1 unreviewed U5D8H4 unreviewed U5DB20 unreviewed U5DCJ2 unreviewed U5FX66 unreviewed V5YM14 reviewed dapb2 W0IWL0 reviewed CHI-L2 Lacks the conserved Glu active site in position 166, which is replaced by an Ala residue, explaining why it is inactive W0UVA9 unreviewed LOC114679273 W0UVD8 unreviewed RNASE9 W1NUB1 unreviewed W1NUM7 unreviewed W1P393 unreviewed W1PAL4 unreviewed W1PNF4 unreviewed W1PWD7 unreviewed W1PX52 unreviewed W5EP13 reviewed W5G1C0 unreviewed LOC123119069 W5M2H7 unreviewed W5M404 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5M4C6 unreviewed W5MBK5 unreviewed W5MDG9 unreviewed W5MDU5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5MI95 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5ML12 unreviewed W5MLR0 unreviewed W5MN41 unreviewed W5MP17 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5MRN0 unreviewed W5MSS7 unreviewed W5MUJ1 unreviewed W5MVC3 unreviewed W5MVN3 unreviewed SUCLG2 W5MXH2 unreviewed W5MXZ0 unreviewed W5N3A5 unreviewed W5N3C0 unreviewed W5N3R1 unreviewed W5N7I5 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NAB0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NCK2 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NDE2 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NDF8 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NE93 unreviewed W5NER0 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation W5NG81 unreviewed W5NGJ4 unreviewed W5NGT0 unreviewed W5NHM9 unreviewed W5NJ17 unreviewed W5NJX8 unreviewed W5NK79 unreviewed W5NNN7 unreviewed Lacks conserved residue(s) required for the propagation of feature annotation X2J508 unreviewed Nlg2 X2J5D8 unreviewed FucTB X2J5N3 unreviewed Gyc32E X2J6Q6 unreviewed GABPI Lacks conserved residue(s) required for the propagation of feature annotation X2J731 unreviewed BcDNA:AT08210 X2J8G3 unreviewed mri X2J8I7 unreviewed Snx1 X2J924 unreviewed KIF26 Lacks conserved residue(s) required for the propagation of feature annotation X2J9F6 unreviewed Cyp6a16 X2JAH0 unreviewed Adhr X2JAH5 unreviewed Dmel\CG4650 X2JAX9 unreviewed ect X2JB25 unreviewed Yp2 X2JCZ1 unreviewed sdt X2JD55 unreviewed Yp1 X2JE21 unreviewed mmd Lacks conserved residue(s) required for the propagation of feature annotation X2JEI8 unreviewed PGRP-SA X2JEK1 unreviewed Dmel\CG34171 Lacks conserved residue(s) required for the propagation of feature annotation X2JEX8 unreviewed Yp3 X2JFI2 unreviewed Dmel\CG45002 X2JFT2 unreviewed goe Lacks conserved residue(s) required for the propagation of feature annotation X2JIZ6 unreviewed sdt X2JKT7 unreviewed Dmel\CG45002 X5JA13 reviewed SEC10a This locus, comprising the single gene At5g12370 in the original reference genome assembly, contains in fact two paralogous genes in tandem, SEC10a (At5g12370) and SEC10b (At5g12365), and a sequence segment of 7 kb in length is missing from the reference genome sequence Z4YNJ9 unreviewed Scd3