id: pn_mapping_set:chaperone_systems label: Chaperone-system PN mappings references: - proteostasis-workbook-2024 - proteostasis-ms1 notes: >- Cross-branch chaperone-system mappings where the PN source is a family, system, or complex role. subject_curations: - subject_code: Cytonuclear proteostasis subject_level: branch curation_status: no_mapping rationale: Reviewed as a top-level PN branch. This is a systems/taxonomy umbrella, not a direct GO assertion; narrower child curations carry any propagating GO mappings. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone subject_level: class curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Folding enzyme subject_level: class curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|Chaperone for alpha-actinin in myofibril assembly subject_level: group curation_status: no_mapping rationale: Reviewed as a contextual PN bucket. The label is useful for curator triage, but no direct GO mapping is appropriate because propagation would add a process, activity, or localization not shared cleanly by all members. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|small HSP system subject_level: group curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases subject_level: group curation_status: mapped target_term: id: GO:0003755 label: peptidyl-prolyl cis-trans isomerase activity mapping_scope: ok_for_propagation_to_go rationale: This PN group is the cytonuclear peptidyl-prolyl isomerase branch. The matching GO molecular-function term is appropriate for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/CWC27/CWC27-ai-review.yaml - PMID:20676357 excluded_subjects: - condition_level: gene_symbol condition_code: CWC27 notes: >- CWC27 is excluded after gene-level review. Although it carries a cyclophilin domain, structural and biochemical work shows it is a catalytically dead pseudo-isomerase (active-site substitutions, no cyclosporin binding, no detectable PPIase activity); the gene review records GO:0003755 as a NOT annotation. CWC27 acts as a spliceosomal scaffold rather than a folding enzyme, so the PPIase-activity term must not propagate to it. - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a specific GO class. The member genes span multiple activities, complexes, or contexts, so propagation from this node would overstate the shared biology; use narrower child or gene-level curations. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: >- Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC subunit subject_level: type curation_status: mapped target_term: id: GO:0005832 label: chaperonin-containing T-complex mapping_scope: ok_for_propagation_to_go rationale: >- This PN path denotes subunits of the cytosolic CCT/TRiC chaperonin complex. Propagation to the GO cellular-component term for the chaperonin-containing T-complex is appropriate, although the PN source is specifically the subunit role class. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|sequence similar non-CCT/TRiC subunit subject_level: type curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class. references: - proteostasis-workbook-2024 - file:human/HSPA12A/HSPA12A-notes.md - file:human/HSPA12B/HSPA12B-notes.md - PMID:12552099 - file:human/HSPA14/HSPA14-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: HSPA12A - condition_level: gene_symbol condition_code: HSPA12B notes: >- Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA12A and HSPA12B are excluded after gene-level review because they are atypical/distant HSP70-family proteins without direct evidence for canonical ATP-dependent protein-folding chaperone activity. By contrast, proteostasis-batch-5 review of HSPA14/HSP70L1 supports the mapping: it has ATP hydrolysis activity and acts in co-translational nascent-chain folding as the HSP70 subunit of the ribosome-associated complex (RAC, with DNAJC2/MPP11), so it is retained. - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor subject_level: type curation_status: mapped target_term: id: GO:0000774 label: adenyl-nucleotide exchange factor activity mapping_scope: ok_for_propagation_to_go representative_genes: - GRPEL1 - GRPEL2 - BAG1 - HSPBP1 rationale: >- These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange inhibitor subject_level: type curation_status: mapped target_term: id: GO:0030544 label: Hsp70 protein binding mapping_scope: ok_for_propagation_to_go rationale: This PN type is represented by ST13/HIP, an HSP70 nucleotide-exchange inhibitor. The shared mechanistic assertion is Hsp70 protein binding. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone subject_level: type curation_status: mapped target_term: id: GO:0030544 label: Hsp70 protein binding mapping_scope: ok_for_propagation_to_go representative_genes: - DNAJA3 - HSCB - DNAJB1 - DNAJB6 rationale: >- In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/DNAJB4/DNAJB4-ai-review.yaml - file:human/DNAJC7/DNAJC7-ai-review.yaml - file:human/DNAJC12/DNAJC12-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: DNAJC27 notes: >- Confirmed for canonical cytosolic/nuclear J-proteins by gene-level review (proteostasis batch 5): DNAJB4, DNAJB5, DNAJC7, DNAJC9, DNAJC12, DNAJC13, DNAJC16, DNAJC17, DNAJC21, DNAJC24 all act as HSP70/HSC70 cochaperones that bind HSP70-family chaperones. For HPD-motif members with direct biochemical data the more specific MF GO:0001671 (ATPase activator activity) is also supported (e.g. DNAJB4, DNAJC24 carry IDA-grade ATPase-stimulation evidence); GO:0030544 Hsp70 protein binding is retained as the safe family-level propagation target. DNAJC27 (RBJ) is EXCLUDED: despite a degenerate J-domain it is a chimeric Rab/J GTP-binding protein that acts as a MEK-ERK scaffold and has no demonstrated HSP70-cochaperone function. - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone subject_level: type curation_status: mapped target_term: id: GO:0031072 label: heat shock protein binding mapping_scope: ok_for_propagation_to_go rationale: This PN type groups joint HSP70/HSP90 cochaperones. The shared mechanistic assertion is binding heat-shock-protein chaperones, while narrower domain labels remain non-mapping unless they carry an independent activity. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class. references: - proteostasis-workbook-2024 notes: >- This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts. - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone subject_level: type curation_status: mapped target_term: id: GO:0051879 label: Hsp90 protein binding mapping_scope: ok_for_propagation_to_go rationale: This PN type groups HSP90 cochaperones. Hsp90 protein binding is the most defensible shared GO molecular-function target for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/CDC37L1/CDC37L1-ai-review.yaml - file:human/AARSD1/AARSD1-ai-review.yaml - file:human/AARSD1/AARSD1-notes.md - PMID:26884463 - file:human/TTC28/TTC28-ai-review.yaml - file:human/TTC28/TTC28-notes.md - PMID:23036704 - PMID:39630868 - file:human/FKBP4/FKBP4-ai-review.yaml - file:human/FKBP5/FKBP5-ai-review.yaml - file:human/FKBP8/FKBP8-ai-review.yaml - file:human/FKBPL/FKBPL-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: AARSD1 - condition_level: gene_symbol condition_code: TTC28 notes: >- AARSD1 is excluded after gene-level review because the HSP90 cochaperone evidence appears to apply to muscle/readthrough-derived Aarsd1L or PTGES3L-AARSD1-like fusion products rather than canonical AARSD1. Keep this as contextual/isoform-associated biology, not a general gene-level Hsp90-binding propagation. TTC28 is excluded because the supported chaperone-related evidence is HSPA8-mediated CMA/microautophagy substrate biology, while its stronger core role is mitotic scaffold/AURKB-associated cell-division biology; the evidence does not support HSP90 cochaperone propagation. By contrast, gene-level review of CDC37L1 (Cdc37-like-1) confirmed this propagation: it is a bona fide HSP90/HSP70 cochaperone with accepted Hsp90 protein binding (GO:0051879). Proteostasis batch 5 added the FKBP immunophilin cochaperones FKBP4/FKBP52, FKBP5/FKBP51, FKBP8/FKBP38 and FKBPL, all confirmed as HSP90 cochaperones that bind Hsp90 (GO:0051879). This also supports keeping the child subtype "CC-TPR and PPIase domain containing" as no_mapping: FKBP4/5/8 carry PPIase activity but FKBPL has no catalytic PPIase domain, so a subtype-level PPIase-activity mapping would over-annotate that member while the shared Hsp90-binding role propagates correctly here. - subject_code: Cytonuclear proteostasis|Chaperone|small HSP system|small HSP subject_level: type curation_status: mapped target_term: id: GO:0044183 label: protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes small heat-shock chaperones. Protein folding chaperone is the appropriate shared molecular-function term. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/HSPB2/HSPB2-ai-review.yaml - file:human/HSPB3/HSPB3-ai-review.yaml - file:human/HSPB7/HSPB7-ai-review.yaml - file:human/HSPB8/HSPB8-ai-review.yaml - file:human/HSPB9/HSPB9-ai-review.yaml notes: >- Confirmed and refined by gene-level review (proteostasis batch 5). HSPB2, HSPB3, HSPB7 and HSPB8 are ATP-independent holdases whose gene-level core molecular function is GO:0051082 (unfolded protein binding) - a more specific holdase term than the family-level GO:0044183 used here for propagation; GO:0044183 is retained as the conservative shared target. Note two member caveats surfaced by review: HSPB7 acts predominantly as an aggregate sequestrase rather than a refolding chaperone, and HSPB9 is a testis- restricted small HSP whose best-supported MF is dynein light chain binding (GO:0045503) rather than general holdase activity, so the holdase mapping is weakest for HSPB9. - subject_code: Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|Cyclophilin type subject_level: type curation_status: mapped target_term: id: GO:0003755 label: peptidyl-prolyl cis-trans isomerase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes cyclophilin-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/CWC27/CWC27-ai-review.yaml - PMID:20676357 excluded_subjects: - condition_level: gene_symbol condition_code: CWC27 notes: >- CWC27 is excluded after gene-level review: it is a catalytically dead cyclophilin-domain pseudo-isomerase (the gene review records GO:0003755 as a NOT annotation), so the cyclophilin PPIase-activity term must not propagate to it. Genuine catalytic cyclophilins in this type retain the mapping. - subject_code: Cytonuclear proteostasis|Folding enzyme|Peptidyl-prolyl isomerases|FKBP type subject_level: type curation_status: mapped target_term: id: GO:0003755 label: peptidyl-prolyl cis-trans isomerase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes FKBP-family peptidyl-prolyl isomerases. The matching GO molecular-function term is appropriate for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: ER proteostasis|Chaperone|HSP70 system|HSP70 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class. references: - proteostasis-workbook-2024 - file:human/HSPA13/HSPA13-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: HSPA13 notes: >- Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. HSPA13/STCH is excluded after gene-level review (proteostasis batch 5): it is an atypical microsomal/ER HSP70 with a truncated substrate-binding domain and a peptide-stimulation-independent ATPase, and its review marks the canonical refolding/foldase terms as over-annotations. Its supported activities are ATP hydrolysis (GO:0016887) and ubiquitin-like protein binding, not canonical ATP-dependent protein-folding chaperone activity, so it should not inherit GO:0140662 from this node. Canonical ER HSP70s (e.g. HSPA5/BiP) retain the mapping. - subject_code: ER proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor subject_level: type curation_status: mapped target_term: id: GO:0000774 label: adenyl-nucleotide exchange factor activity mapping_scope: ok_for_propagation_to_go representative_genes: - GRPEL1 - GRPEL2 - BAG1 - HSPBP1 rationale: >- These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: ER proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone subject_level: type curation_status: mapped target_term: id: GO:0030544 label: Hsp70 protein binding mapping_scope: ok_for_propagation_to_go representative_genes: - DNAJA3 - HSCB - DNAJB1 - DNAJB6 rationale: >- In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: ER proteostasis|Chaperone|HSP90 system|HSP90 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class. references: - proteostasis-workbook-2024 notes: >- This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts. - subject_code: Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, the type label HSP70 within the chaperone/HSP70-system context denotes canonical HSP70 chaperones. Propagation to the GO molecular function ATP-dependent protein folding chaperone is appropriate for curation, but the PN family label is not itself a strict GO-equivalent class. references: - proteostasis-workbook-2024 notes: >- Conditional mapping. The source string HSP70 occurs in multiple PN branches, so the chaperone and HSP70-system context is required for this mapping. - subject_code: Mitochondrial proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor subject_level: type curation_status: mapped target_term: id: GO:0000774 label: adenyl-nucleotide exchange factor activity mapping_scope: ok_for_propagation_to_go representative_genes: - GRPEL1 - GRPEL2 - BAG1 - HSPBP1 rationale: >- These PN entries denote nucleotide exchange factors that reset HSP70 chaperones by promoting ADP release. The current validated GO cache does not expose a more HSP70-specific exchange-factor term, so adenyl-nucleotide exchange factor activity is the best supported target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Mitochondrial proteostasis|Chaperone|HSP70 system|J-domain containing HSP70 cochaperone subject_level: type curation_status: mapped target_term: id: GO:0030544 label: Hsp70 protein binding mapping_scope: ok_for_propagation_to_go representative_genes: - DNAJA3 - HSCB - DNAJB1 - DNAJB6 rationale: >- In the PN hierarchy, this type denotes J-domain cochaperones assigned to the HSP70 system. Their shared mechanistic role is direct interaction with HSP70-family chaperones, making Hsp70 protein binding the most defensible GO target in the current cache. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/DNAJC19/DNAJC19-ai-review.yaml - file:human/DNAJC15/DNAJC15-ai-review.yaml - file:human/DNAJC11/DNAJC11-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: DNAJC11 notes: >- Confirmed for genuine mitochondrial import-motor J-proteins by gene-level review (proteostasis batch 5): DNAJC19/TIM14 and DNAJC15/MCJ are inner-membrane PAM/TIM23-motor J-proteins that stimulate the mortalin (HSPA9/mtHSP70) ATPase, so for these the more specific MF GO:0001671 (ATPase activator activity) also applies; GO:0030544 Hsp70 protein binding is retained as the family-level propagation target. DNAJC11 is EXCLUDED: although it carries a J-domain, the human protein is a structural component of the mitochondrial intermembrane-bridging (MIB)/MICOS complex required for cristae organization, with no demonstrated HSP70-cochaperone activity, so it should not inherit the Hsp70-binding MF from this node. - subject_code: Mitochondrial proteostasis|Chaperone|HSP90 system|HSP90 subject_level: type curation_status: mapped target_term: id: GO:0140662 label: ATP-dependent protein folding chaperone mapping_scope: ok_for_propagation_to_go rationale: >- In the PN hierarchy, HSP90 within the chaperone/HSP90-system context denotes canonical HSP90 chaperones across multiple proteostasis branches. Propagation to ATP-dependent protein folding chaperone is appropriate, while strict equivalence would overstate the family label as a GO class. references: - proteostasis-workbook-2024 notes: >- This mirrors the HSP70 mapping strategy and intentionally covers the cytonuclear, ER, and mitochondrial HSP90-system contexts. - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Open state cofactor subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Phosducin-like proteins subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|Tubulin folding subject_level: subtype curation_status: mapped target_term: id: GO:0007023 label: post-chaperonin tubulin folding pathway mapping_scope: ok_for_propagation_to_go rationale: This PN subtype is the tubulin-folding cofactor branch downstream of CCT/TRiC. The GO post-chaperonin tubulin folding pathway term captures the shared pathway role. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|CCT/TRiC system|CCT/TRiC cochaperone|prefoldin subunit subject_level: subtype curation_status: no_mapping rationale: Reviewed as a mixed canonical-prefoldin and prefoldin-like subtype. Canonical PFDN/VBP1 members map cleanly to GO:0016272 prefoldin complex, but UXT/URI1-like members should not inherit canonical prefoldin-complex membership from this source node; use gene-level curation for those distinctions. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|BAG domain subtype subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSP110/GRP170 subtype subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange factor|HSPBP1 subtype subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70 system|HSP70 nucleotide exchange inhibitor|TPR domain subtype subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and Armadillo domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and CS domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and Cns1/TTC4 wheel domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and J domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and PPIase domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a mixed TPR/PPIase-domain subtype. Although several members are active peptidyl-prolyl isomerases, the bucket also contains PPIase-like cochaperones, so subtype-level PPIase propagation would overstate the shared activity. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and RPAP3-like C-terminal domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and SGTA dimerization domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and STI/HOP domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and methyltransferase domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR and phosphatase domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain and Ub ligase subject_level: subtype curation_status: mapped target_term: id: GO:0061630 label: ubiquitin protein ligase activity mapping_scope: ok_for_propagation_to_go rationale: This PN subtype explicitly denotes TPR-containing ubiquitin ligases in the HSP70/HSP90 co-chaperone branch. The shared catalytic assertion is ubiquitin protein ligase activity. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP70-HSP90 system integration|HSP70-HSP90 joint cochaperone|CC-TPR domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and Armadillo domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and PPIase domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a mixed HSP90 cochaperone subtype with FKBP/PPIase-like members. The parent HSP90-cochaperone mapping captures the shared HSP90-binding role; a subtype-level PPIase mapping would overstate the activity for all members. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CC-TPR and RPAP3-like C-terminal domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|CS domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR and CS domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|TPR domain containing subject_level: subtype curation_status: no_mapping rationale: Reviewed as a family/domain/subtype label. It classifies PN members but is not itself a GO annotation target; any functional assertion should come from a parent role mapping or gene-specific review. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Cytonuclear proteostasis|Chaperone|HSP90 system|HSP90 cochaperone|no characteristic domain subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket that is already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1