id: pn_mapping_set:translation label: Translation PN mappings references: - proteostasis-workbook-2024 - proteostasis-ms1 notes: >- Curated PN-to-GO mappings for cytosolic translation and associated quality-control machinery. subject_curations: - subject_code: Translation subject_level: branch curation_status: context_only target_term: id: GO:0006412 label: translation mapping_scope: too_broad_to_propagate rationale: >- The PN Translation branch is organized around the translation apparatus and immediately associated cotranslational quality-control systems. GO translation is the closest high-level process label, but the PN branch also contains adjacent machinery such as ribosome biogenesis and nascent-chain handling. Keeping this relationship is useful for interpretation, but it is too broad to project safely onto every member. references: - proteostasis-workbook-2024 - proteostasis-ms1 notes: >- Retained as a broad semantic anchor only. This mapping should not drive candidate GO projections because it over-annotates assembly, maturation, and quality-control factors placed within the PN Translation branch. - subject_code: Translation|Cytosolic translation subject_level: class curation_status: context_only target_term: id: GO:0002181 label: cytoplasmic translation mapping_scope: too_broad_to_propagate rationale: >- The PN class Cytosolic translation is centered on the cytoplasmic translation apparatus and process, but it also houses supporting machinery such as ribosome biogenesis factors. The GO process term is a useful high-level label for the class, but propagating it to all members would over-annotate genes whose PN placement is through assembly or maturation context rather than core cytoplasmic translation. references: - proteostasis-workbook-2024 - proteostasis-ms1 notes: >- AATF is a representative failure mode: PN places it under Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex, where projecting GO cytoplasmic translation would be too broad. - subject_code: Translation|Mitochondrial translation subject_level: class curation_status: context_only target_term: id: GO:0032543 label: mitochondrial translation mapping_scope: too_broad_to_propagate rationale: This PN class is a useful mitochondrial-translation context, but it contains ribosome components, assembly factors, tRNA synthetases, regulatory factors, and translation factors. Direct propagation to mitochondrial translation would over-annotate several adjacent machinery classes, so the relationship is retained as context only. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome subject_level: group curation_status: mapped target_term: id: GO:0022626 label: cytosolic ribosome mapping_scope: ok_for_propagation_to_go rationale: >- This PN group denotes the cytosolic ribosome within the cytosolic translation branch. The more specific GO cellular-component term cytosolic ribosome is preferable to the broader ribosome term. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor subject_level: group curation_status: mapped target_term: id: GO:0042254 label: ribosome biogenesis mapping_scope: ok_for_propagation_to_go representative_genes: - AATF - UTP4 - IMP3 - NOP56 rationale: >- This PN group collects factors assigned through cytosolic ribosome biogenesis, including SSU-processosome and pre-60S maturation machinery. The full PN path resolves the earlier over-annotation problem: these genes are not being placed by core translational elongation or decoding, but by assembly and maturation of ribosomal subunits. GO ribosome biogenesis is therefore the appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms1 notes: >- This is the positive complement to the broad class mapping above. It is intended to capture cases like AATF, where the deeper PN path points to ribosome-biogenesis machinery rather than cytoplasmic translation itself. - subject_code: Translation|Cytosolic translation|Ribosome-associated QC subject_level: group curation_status: mapped target_term: id: GO:0006515 label: protein quality control for misfolded or incompletely synthesized proteins mapping_scope: ok_for_propagation_to_go rationale: >- The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation elongation subject_level: group curation_status: context_only target_term: id: GO:0006414 label: translational elongation mapping_scope: too_broad_to_propagate rationale: This PN group is an elongation-context bucket, but it also contains tRNA synthetases, tRNA deacylases, and multisynthetase-complex members whose direct shared assertions are narrower molecular functions or complexes. The elongation relationship is retained as context only. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation initiation subject_level: group curation_status: mapped target_term: id: GO:0006413 label: translational initiation mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes cytosolic translation initiation factors and complexes. Translational initiation is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination subject_level: group curation_status: mapped target_term: id: GO:0006415 label: translational termination mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes cytosolic translation termination and release factors. Translational termination is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor subject_level: group curation_status: mapped target_term: id: GO:0061668 label: mitochondrial ribosome assembly mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes factors for mitoribosome assembly and maturation. Mitochondrial ribosome assembly is the most specific shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Ribosome subject_level: group curation_status: mapped target_term: id: GO:0005761 label: mitochondrial ribosome mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes the mitochondrial ribosome. The GO mitochondrial ribosome cellular-component term resolves the previous deferred state. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Ribosome recycling subject_level: group curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation elongation subject_level: group curation_status: context_only target_term: id: GO:0070125 label: mitochondrial translational elongation mapping_scope: too_broad_to_propagate rationale: This PN group is a mitochondrial-elongation context, but it also contains mitochondrial tRNA synthetases and GatCAB amidotransferase components. The lower-level mappings capture the defensible shared functions, so this ancestor is context only. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation initiation subject_level: group curation_status: mapped target_term: id: GO:0070124 label: mitochondrial translational initiation mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes mitochondrial translation initiation machinery. The matching GO process term is appropriate for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation regulation subject_level: group curation_status: no_mapping rationale: Reviewed as a contextual PN bucket. The label is useful for curator triage, but no direct GO mapping is appropriate because propagation would add a process, activity, or localization not shared cleanly by all members. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation termination subject_level: group curation_status: mapped target_term: id: GO:0070126 label: mitochondrial translational termination mapping_scope: ok_for_propagation_to_go rationale: This PN group denotes mitochondrial translation termination machinery. The matching GO process term is appropriate for propagation. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide subject_level: type curation_status: mapped target_term: id: GO:0006474 label: N-terminal protein amino acid acetylation mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes N-terminal acetyltransferase machinery acting on nascent peptides. The GO N-terminal acetylation process is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal methionine cleavage from nascent peptide subject_level: type curation_status: mapped target_term: id: GO:0004239 label: initiator methionyl aminopeptidase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type is represented by METAP1/METAP2. Initiator methionyl aminopeptidase activity captures the shared catalytic function. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal myristoylation of nascent peptide subject_level: type curation_status: mapped target_term: id: GO:0006499 label: N-terminal protein myristoylation mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes NMT-mediated nascent-chain myristoylation. The GO N-terminal protein myristoylation process is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning subject_level: type curation_status: mapped target_term: id: GO:0051083 label: "'de novo' cotranslational protein folding" mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes cotranslational chaperoning of nascent peptides. The GO de novo cotranslational protein folding term is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|60S maturation subject_level: type curation_status: mapped target_term: id: GO:0000027 label: ribosomal large subunit assembly mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes 60S maturation factors. Ribosomal large subunit assembly captures the shared maturation process. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome subject_level: type curation_status: mapped target_term: id: GO:0032040 label: small-subunit processome mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes SSU processosome factors. The GO small-subunit processome term is the direct complex target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-40S complex subject_level: type curation_status: mapped target_term: id: GO:0030688 label: preribosome, small subunit precursor mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes pre-40S particles. The GO preribosome small-subunit precursor term is the direct complex target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-5S rRNA processing nuclease subject_level: type curation_status: mapped target_term: id: GO:0006364 label: rRNA processing mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes nucleases in pre-5S rRNA processing. rRNA processing is the appropriate shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex subject_level: type curation_status: mapped target_term: id: GO:0030687 label: preribosome, large subunit precursor mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes pre-60S particles. The GO preribosome large-subunit precursor term is the direct complex target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S export adapter subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-rRNA processing nuclease subject_level: type curation_status: mapped target_term: id: GO:0006364 label: rRNA processing mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes pre-rRNA processing nucleases. rRNA processing is the appropriate shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|rRNA modification subject_level: type curation_status: mapped target_term: id: GO:0000154 label: rRNA modification mapping_scope: ok_for_propagation_to_go rationale: This PN type is a broad rRNA-modification bucket in ribosome biogenesis. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|Deubiquitination subject_level: type curation_status: mapped target_term: id: GO:0101005 label: deubiquitinase activity mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type denotes deubiquitinases acting in ribosome-associated quality control. Deubiquitinase activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/OTUD3/OTUD3-ai-review.yaml - file:human/USP21/USP21-ai-review.yaml notes: >- Confirmed by gene-level review (proteostasis batch 6): OTUD3 and USP21 are both cysteine-type deubiquitinases (GO:0004843), and both negatively regulate 40S ribosomal-protein ubiquitination in RQC (USP21 removes the eS10/uS10 ubiquitin marks placed by ZNF598). (Note: the originally-listed "USP21" candidate symbol resolved to the synonym gene USP25; both the real USP21 (Q9UK80) and USP25 (Q9UHP3) are bona fide DUBs.) - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|O-GlcNAclyation subject_level: type curation_status: mapped target_term: id: GO:0006493 label: protein O-linked glycosylation mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type captures O-GlcNAc modification in the ribosome-associated quality-control context. Protein O-linked glycosylation is the appropriate GO process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|Ribosomal rescue subject_level: type curation_status: mapped target_term: id: GO:0072344 label: rescue of stalled cytosolic ribosome mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type denotes rescue of stalled cytosolic ribosomes. The matching GO process term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/PELO/PELO-ai-review.yaml - file:human/HBS1L/HBS1L-ai-review.yaml - file:human/GTPBP2/GTPBP2-ai-review.yaml - file:human/ZNF598/ZNF598-ai-review.yaml - file:human/TRIP4/TRIP4-ai-review.yaml notes: >- Confirmed by gene-level review (proteostasis batch 6): the PELO(Dom34)-HBS1L complex and the PELO-GTPBP2 complex split stalled/collided ribosomes (no-go and non-stop decay); ZNF598 is the collision-sensing E3 that initiates rescue; and TRIP4/ASC-1 (RQT/ASC-1 complex) disassembles K63-ubiquitinated collided ribosomes. RACK1 is retained but is a structural 40S platform for collision sensing rather than an autonomous rescue factor, and GTPBP1's best-supported role is ribosome-associated mRNA surveillance; treat those two as weaker members of this rescue mapping. - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|UFMylation subject_level: type curation_status: mapped target_term: id: GO:0071569 label: protein ufmylation mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type denotes UFM1 conjugation in ribosome quality control. Protein ufmylation is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/UFM1/UFM1-ai-review.yaml - file:human/UBA5/UBA5-ai-review.yaml - file:human/UFC1/UFC1-ai-review.yaml - file:human/UFL1/UFL1-ai-review.yaml - file:human/DDRGK1/DDRGK1-ai-review.yaml notes: >- Confirmed by gene-level review (proteostasis batch 6): the UFMylation cascade members UFM1 (modifier), UBA5 (E1), UFC1 (E2), UFL1 (E3) and the cofactor DDRGK1/UFBP1 all participate in protein ufmylation, notably UFMylation of RPL26 on ER-bound/stalled ribosomes. The proteases UFSP1 and UFSP2 are retained as cascade members but catalyze the REVERSE reaction (deUFMylation / pro-UFM1 maturation); for those two the forward `protein ufmylation` term is pathway-context rather than their direct activity. - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitin recognition subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|Ubiquitination subject_level: type curation_status: mapped target_term: id: GO:0016567 label: protein ubiquitination mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type denotes ubiquitination events on stalled translation complexes. Protein ubiquitination is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/LTN1/LTN1-ai-review.yaml - file:human/MKRN1/MKRN1-ai-review.yaml - file:human/MKRN2/MKRN2-ai-review.yaml notes: >- Confirmed by gene-level review (proteostasis batch 6): LTN1/Listerin is the RQC E3 that ubiquitinates 60S-stalled nascent chains, and the makorin E3s MKRN1 (and paralog MKRN2) ubiquitinate poly(A)/polylysine-stalled nascent chains - all carry ubiquitin protein ligase activity (GO:0061630) and act in protein ubiquitination at stalled ribosomes. - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|VCP system for RQC subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome-associated QC|ubiquitination of eEF1A on stalled ribosomes subject_level: type curation_status: mapped target_term: id: GO:0016567 label: protein ubiquitination mapping_scope: ok_for_propagation_to_go rationale: This PN RQC type is a specific ubiquitination bucket for eEF1A on stalled ribosomes. Protein ubiquitination is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/RNF14/RNF14-ai-review.yaml - file:human/RNF25/RNF25-ai-review.yaml - file:human/GCN1/GCN1-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: GCN1 notes: >- Confirmed for the RNF14-RNF25 RQC ubiquitin ligases by gene-level review (proteostasis batch 6): both are RING/RBR E3s (GO:0061630) that ubiquitinate elongation factors (eEF1A) and other components on collided ribosomes. GCN1 is EXCLUDED: it carries no E3 ligase activity - its gene-level core function is stalled-ribosome sensor activity (GO:0170011) coupling ribosome collisions to GCN2/eIF2alpha (the integrated stress response), so it must not inherit the protein-ubiquitination process term from this node. - subject_code: Translation|Cytosolic translation|Ribosome|Cytoribosome subject_level: type curation_status: mapped target_term: id: GO:0022626 label: cytosolic ribosome mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes cytosolic ribosome components. The GO cytosolic ribosome term is the direct cellular-component target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation elongation|EEF1B complex subject_level: type curation_status: mapped target_term: id: GO:0005853 label: eukaryotic translation elongation factor 1 complex mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes EEF1B complex components. The GO eukaryotic translation elongation factor 1 complex term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation elongation|assorted elongation factors subject_level: type curation_status: mapped target_term: id: GO:0003746 label: translation elongation factor activity mapping_scope: ok_for_propagation_to_go rationale: This PN type groups cytosolic elongation factors. Translation elongation factor activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/EEF2K/EEF2K-ai-review.yaml excluded_subjects: - condition_level: gene_symbol condition_code: EEF2K notes: >- EEF2K is excluded after gene-level review (proteostasis batch 6). EEF2K is not a translation elongation factor: it is the alpha-kinase eEF2 kinase (GO:0004686 elongation factor-2 kinase activity) that phosphorylates eEF2 on Thr-56 to NEGATIVELY regulate elongation. Its review removes the translation-factor MF annotation. Inheriting GO:0003746 from this node would miscast the regulator as a factor; genuine eEFs in this group retain the mapping. - subject_code: Translation|Cytosolic translation|Translation elongation|multisynthase complex subject_level: type curation_status: mapped target_term: id: GO:0017101 label: aminoacyl-tRNA synthetase multienzyme complex mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes the multisynthetase complex. The GO aminoacyl-tRNA synthetase multienzyme complex term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation elongation|tRNA deacylase subject_level: type curation_status: mapped target_term: id: GO:0002161 label: aminoacyl-tRNA deacylase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes tRNA deacylases. The GO aminoacyl-tRNA deacylase activity term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation elongation|tRNA synthetase subject_level: type curation_status: mapped target_term: id: GO:0004812 label: aminoacyl-tRNA ligase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes cytosolic aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/AARSD1/AARSD1-ai-review.yaml - file:human/AARSD1/AARSD1-notes.md - PMID:38869066 excluded_subjects: - condition_level: gene_symbol condition_code: AARSD1 notes: >- AARSD1 is excluded after gene-level review because canonical AARSD1 is an AlaX-family aminoacyl-tRNA deacylase/trans-editing factor rather than an aminoacyl-tRNA ligase. It should be handled through the tRNA deacylase / translational-fidelity biology, not synthetase propagation. - subject_code: Translation|Cytosolic translation|Translation initiation|assorted initiation factors subject_level: type curation_status: mapped target_term: id: GO:0003743 label: translation initiation factor activity mapping_scope: ok_for_propagation_to_go rationale: This PN type groups cytosolic initiation factors not represented by a single named complex. Translation initiation factor activity is the shared target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation initiation|eIF2 complex subject_level: type curation_status: mapped target_term: id: GO:0005850 label: eukaryotic translation initiation factor 2 complex mapping_scope: ok_for_propagation_to_go rationale: >- This PN type denotes component membership in the eIF2 complex. Propagation to the matching GO cellular-component term is appropriate. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation initiation|eIF2B complex subject_level: type curation_status: mapped target_term: id: GO:0005851 label: eukaryotic translation initiation factor 2B complex mapping_scope: ok_for_propagation_to_go rationale: >- This PN type denotes component membership in the eIF2B complex. The corresponding GO cellular-component term is an appropriate propagation target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation initiation|eIF3 complex subject_level: type curation_status: mapped target_term: id: GO:0005852 label: eukaryotic translation initiation factor 3 complex mapping_scope: ok_for_propagation_to_go rationale: >- This PN type denotes component membership in the eIF3 complex. Propagation to the matching GO cellular-component term is appropriate. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation initiation|eIF4F complex subject_level: type curation_status: mapped target_term: id: GO:0016281 label: eukaryotic translation initiation factor 4F complex mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes eIF4F complex components. The GO eukaryotic translation initiation factor 4F complex term resolves the previous deferred state. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination|Modulation of termination subject_level: type curation_status: no_mapping rationale: Reviewed as a contextual PN bucket. The label is useful for curator triage, but no direct GO mapping is appropriate because propagation would add a process, activity, or localization not shared cleanly by all members. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination|Polypeptide release subject_level: type curation_status: mapped target_term: id: GO:0003747 label: translation release factor activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes release factors that mediate polypeptide release. Translation release factor activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination|Ribosome splitting subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination|Stop codon recognition subject_level: type curation_status: mapped target_term: id: GO:0016149 label: translation release factor activity, codon specific mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes codon-specific stop-codon recognition by release factors. The GO codon-specific release-factor activity term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Translation termination|tRNA, mRNA release subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit assembly subject_level: type curation_status: mapped target_term: id: GO:0061668 label: mitochondrial ribosome assembly mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes 28S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA chaperone subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification subject_level: type curation_status: mapped target_term: id: GO:0000154 label: rRNA modification mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes modification of mitochondrial small-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit assembly subject_level: type curation_status: mapped target_term: id: GO:0061668 label: mitochondrial ribosome assembly mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes 39S mitoribosomal subunit assembly factors. Mitochondrial ribosome assembly is the shared process target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA chaperone subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification subject_level: type curation_status: mapped target_term: id: GO:0000154 label: rRNA modification mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes modification of mitochondrial large-subunit rRNA. GO rRNA modification captures the shared process without over-specifying methylation versus other modification chemistries. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Regulation of 28S-39S subunit association subject_level: type curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|Specific function in mitoribosome biogenesis unknown subject_level: type curation_status: no_mapping rationale: Reviewed as an explicit unknown-function bucket in the PN taxonomy. No GO mapping should be propagated until the source category is made mechanistically specific. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease subject_level: type curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Ribosome|Mitoribosome subject_level: type curation_status: mapped target_term: id: GO:0005761 label: mitochondrial ribosome mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes mitoribosome components. The GO mitochondrial ribosome term is the direct cellular-component target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex subject_level: type curation_status: mapped target_term: id: GO:0030956 label: glutamyl-tRNA(Gln) amidotransferase complex mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes the mitochondrial GatCAB amidotransferase complex. The GO glutamyl-tRNA(Gln) amidotransferase complex term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation elongation|assorted elongation factors subject_level: type curation_status: mapped target_term: id: GO:0003746 label: translation elongation factor activity mapping_scope: ok_for_propagation_to_go rationale: This PN type groups mitochondrial elongation factors. Translation elongation factor activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation elongation|tRNA synthetase subject_level: type curation_status: mapped target_term: id: GO:0004812 label: aminoacyl-tRNA ligase activity mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes mitochondrial aminoacyl-tRNA synthetases. The GO aminoacyl-tRNA ligase activity term is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation initiation|assorted initiation factors subject_level: type curation_status: mapped target_term: id: GO:0003743 label: translation initiation factor activity mapping_scope: ok_for_propagation_to_go rationale: This PN type groups mitochondrial initiation factors. Translation initiation factor activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation termination|Normal termination subject_level: type curation_status: mapped target_term: id: GO:0070126 label: mitochondrial translational termination mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes normal mitochondrial translation termination. The GO mitochondrial translational termination process is the shared target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation termination|Termination on stalled ribosomes subject_level: type curation_status: mapped target_term: id: GO:7770016 label: rescue of stalled mitochondrial ribosome mapping_scope: ok_for_propagation_to_go rationale: This PN type denotes handling of stalled mitochondrial ribosomes. The GO rescue of stalled mitochondrial ribosome process is the best matching target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|Modulator of NatA and NatE complexes subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatA/NatE complex component subject_level: subtype curation_status: mapped target_term: id: GO:0031415 label: NatA complex mapping_scope: ok_for_propagation_to_go rationale: >- This subtype is an exact cellular-component match: members are subunits of the NatA N-terminal acetyltransferase complex. The parent maps the BP (GO:0006474 N-terminal protein amino acid acetylation); this node adds the complementary, non-redundant complex-membership CC term. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/NAA10/NAA10-ai-review.yaml - file:human/NAA15/NAA15-ai-review.yaml notes: >- Upgraded from no_mapping after gene-level review (proteostasis batch 6): both NAA10 (catalytic) and NAA15 (auxiliary/ribosome-anchoring) ACCEPT NatA complex (GO:0031415) membership. The catalytic N-terminal acetyltransferase MF (GO:0004596) belongs to NAA10 specifically and is captured at the gene level, not propagated from this CC node. - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatB complex component subject_level: subtype curation_status: mapped target_term: id: GO:0031416 label: NatB complex mapping_scope: ok_for_propagation_to_go rationale: >- Exact cellular-component match: members are subunits of the NatB N-terminal acetyltransferase complex. Complements the parent BP mapping with the complex-membership CC term. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/NAA25/NAA25-ai-review.yaml notes: >- Upgraded from no_mapping after gene-level review (proteostasis batch 6): NAA25 is the non-catalytic auxiliary subunit of NatB (catalytic subunit NAA20) and ACCEPTs NatB complex (GO:0031416) membership; NAA25 carries no acetyltransferase catalytic activity itself. - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatC complex component subject_level: subtype curation_status: mapped target_term: id: GO:0031417 label: NatC complex mapping_scope: ok_for_propagation_to_go rationale: >- Exact cellular-component match: members are subunits of the NatC N-terminal acetyltransferase complex. Complements the parent BP mapping with the complex-membership CC term. references: - proteostasis-workbook-2024 - proteostasis-ms1 - file:human/NAA30/NAA30-ai-review.yaml - file:human/NAA35/NAA35-ai-review.yaml - file:human/NAA38/NAA38-ai-review.yaml notes: >- Upgraded from no_mapping after gene-level review (proteostasis batch 6): NAA30 (catalytic), NAA35 (auxiliary) and NAA38 (Sm-like auxiliary) ACCEPT NatC complex (GO:0031417) membership. The Met-N-terminal acetyltransferase MF belongs to the catalytic subunit NAA30 and is captured at the gene level. - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatD, sole component subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|N-terminal acetylation of nascent peptide|NatE complex component subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: >- Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide chaperoning|RAC component subject_level: subtype curation_status: mapped target_term: id: GO:0051083 label: "'de novo' cotranslational protein folding" mapping_scope: ok_for_propagation_to_go rationale: >- The ribosome-associated complex is a cotranslational chaperone system for emerging nascent chains. The PN subtype is a specific component class within this mechanism, so propagation to GO 'de novo' cotranslational protein folding is justified but not exact. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Nascent peptide husbandry|Nascent peptide sorting|NAC component subject_level: subtype curation_status: mapped target_term: id: GO:0005854 label: nascent polypeptide-associated complex mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes NAC components. The GO nascent polypeptide-associated complex term is the direct complex target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|EMG1 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|IMP3-IMP4 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|RCL1-BMS1 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|U3 snoRNP complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-A complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-B complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|SSU processosome|UTP-C complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|5S RNP complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|ANN complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|NF45-NF90 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|PeBoW complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|Rix1 complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|XND complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome biogenesis factor|pre-60S complex|non 5S RNP complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome|Cytoribosome|40S subunit subject_level: subtype curation_status: mapped target_term: id: GO:0022627 label: cytosolic small ribosomal subunit mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes 40S cytosolic ribosomal subunit components. The GO cytosolic small ribosomal subunit term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Cytosolic translation|Ribosome|Cytoribosome|60S subunit subject_level: subtype curation_status: mapped target_term: id: GO:0022625 label: cytosolic large ribosomal subunit mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes 60S cytosolic ribosomal subunit components. The GO cytosolic large ribosomal subunit term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|28S subunit rRNA modification|rRNA methylation subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA methylation subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|39S subunit rRNA modification|rRNA pseudouridylation subject_level: subtype curation_status: mapped target_term: id: GO:0120159 label: rRNA pseudouridine synthase activity mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes mitochondrial rRNA pseudouridylation factors. rRNA pseudouridine synthase activity is the shared molecular-function target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|RNAse Z subject_level: subtype curation_status: no_mapping rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Mitoribosome biogenesis factor|pre-rRNA processing nuclease|Subunit of RNAse P complex subject_level: subtype curation_status: no_mapping rationale: Reviewed as a narrower taxonomy bucket already covered by a curated parent mapping or by gene-level annotations. No additional direct GO mapping is appropriate from this node. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Ribosome|Mitoribosome|28S subunit subject_level: subtype curation_status: mapped target_term: id: GO:0005763 label: mitochondrial small ribosomal subunit mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes 28S mitochondrial small ribosomal subunit components. The GO mitochondrial small ribosomal subunit term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Ribosome|Mitoribosome|39S subunit subject_level: subtype curation_status: mapped target_term: id: GO:0005762 label: mitochondrial large ribosomal subunit mapping_scope: ok_for_propagation_to_go rationale: This PN subtype denotes 39S mitochondrial large ribosomal subunit components. The GO mitochondrial large ribosomal subunit term is the direct target. references: - proteostasis-workbook-2024 - proteostasis-ms1 - subject_code: Translation|Mitochondrial translation|Translation elongation|Amidotransferase complex|Conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln) subject_level: subtype curation_status: mapped target_term: id: GO:0030956 label: glutamyl-tRNA(Gln) amidotransferase complex mapping_scope: ok_for_propagation_to_go rationale: This PN subtype is the GatCAB-mediated conversion of Glu-tRNA(Gln) to Gln-tRNA(Gln). The GO amidotransferase complex term is the direct shared target. references: - proteostasis-workbook-2024 - proteostasis-ms1